Protein Name ATP binding cassette subfamily C member 8
Organism Rattus norvegicus
Gene ID 25559
Gene Symbol

Abcc8

UniProt Q09429 (ABCC8_RAT), Q70X90 (Q70X90_RAT)
Relationships Total Number of functionally related compound(s) : 92
Total Number of Articles : 121
Description

ATP binding cassette subfamily C member 8

Gene Summary

Predicted to enable adenyl ribonucleotide binding activity; monoatomic cation transmembrane transporter activity; and transmembrane transporter binding activity. Involved in several processes, including learning or memory; negative regulation of blood-brain barrier permeability; and negative regulation of low-density lipoprotein particle clearance. Located in sarcolemma and synaptic vesicle membrane. Part of inward rectifying potassium channel. Is active in presynaptic membrane. Used to study brain edema; cardiac arrest; hypoglycemia; and middle cerebral artery infarction. Biomarker of Parkinsonism; epilepsy; sciatic neuropathy; and status epilepticus. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple) and hypertension. Orthologous to human ABCC8 (ATP binding cassette subfamily C member 8). [provided by Alliance of Genome Resources, May 2025]

synonyms
  • ATP-binding cassette sub-family C member 8
  • ATP-binding cassette transporter sub-family C member 8
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 8
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Properties