| Protein Name | cAMP responsive element binding protein 1 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 81646 |
| Gene Symbol | Creb1 |
| UniProt | P15337 (CREB1_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
811
Total Number of Articles : 1571 |
Description |
cAMP responsive element binding protein 1 |
| Gene Summary |
Enables several functions, including Hsp70 protein binding activity; arrestin family protein binding activity; and histone acetyltransferase binding activity. Involved in several processes, including learning or memory; regulation of apoptotic process; and regulation of gene expression. Located in several cellular components, including axon; chromatin; and mitochondrial matrix. Part of transcription regulator complex. Used to study several diseases, including alcohol use disorder; cerebrovascular disease (multiple); cocaine abuse; obsessive-compulsive disorder; and substance dependence (multiple). Biomarker of several diseases, including Huntington's disease; alcohol dependence; alcohol use disorder; amphetamine abuse; and drug dependence (multiple). Human ortholog(s) of this gene implicated in Parkinson's disease; alcohol dependence; and heroin dependence. Orthologous to human CREB1 (cAMP responsive element binding protein 1). [provided by Alliance of Genome Resources, May 2025] |
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