Protein Name cytochrome P450, family 21, subfamily a, polypeptide 1
Organism Mus musculus
Gene ID 13079
Gene Symbol

Cyp21a1

UniProt P03940 (CP21A_MOUSE), A0A0R4J048 (A0A0R4J048_MOUSE), Q3UJ92 (Q3UJ92_MOUSE)
Relationships Total Number of functionally related compound(s) : 641
Total Number of Articles : 648
Description

cytochrome P450, family 21, subfamily a, polypeptide 1

Gene Summary

Predicted to enable 17-hydroxyprogesterone 21-hydroxylase activity; heme binding activity; and progesterone 21-hydroxylase activity. Predicted to be involved in steroid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including adrenal gland; lung; metanephros; spleen; and testis. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia. Orthologous to several human genes including CYP21A2 (cytochrome P450 family 21 subfamily A member 2). [provided by Alliance of Genome Resources, May 2025]

synonyms
  • steroid 21-hydroxylase
  • 21-OHase
  • 21-hydroxylase
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Properties