| Protein Name | chitinase 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 1118 |
| Gene Symbol | CHIT1 |
| UniProt | Q13231 (CHIT1_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
254
Total Number of Articles : 178 |
Description |
chitinase 1 |
| Gene Summary |
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012] |
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