| Protein Name | myelocytomatosis oncogene |
|---|---|
| Organism | Mus musculus |
| Gene ID | 17869 |
| Gene Symbol | Myc |
| UniProt | P01108 (MYC_MOUSE), F6PX41 (F6PX41_MOUSE), B2RSN1 (B2RSN1_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
289
Total Number of Articles : 316 |
Description |
myelocytomatosis oncogene |
| Gene Summary |
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Under conditions of stress, such as high cell densities and methionine deprivation, there is a specific and dramatic increase in the synthesis of the non-AUG initiated protein, suggesting its importance in times of adversity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010] |
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