Protein Name solute carrier family 18 member A1
Organism Homo sapiens
Gene ID 6570
Gene Symbol

SLC18A1

UniProt P54219 (VMAT1_HUMAN), Q96GL6 (Q96GL6_HUMAN)
Relationships Total Number of functionally related compound(s) : 36
Total Number of Articles : 37
Description

solute carrier family 18 member A1

Gene Summary

The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008]

synonyms
  • chromaffin granule amine transporter
  • solute carrier family 18 (vesicular monoamine transporter), member 1
  • solute carrier family 18 (vesicular monoamine), member 1
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Properties