| Protein Name | low density lipoprotein receptor |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 300438 |
| Gene Symbol | Ldlr |
| UniProt | P35952 (LDLR_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
171
Total Number of Articles : 239 |
Description |
low density lipoprotein receptor |
| Gene Summary |
Enables low-density lipoprotein particle receptor activity. Involved in several processes, including cholesterol homeostasis; positive regulation of triglyceride catabolic process; and response to glucagon. Located in caveola and recycling endosome membrane. Used to study aortic atherosclerosis; atherosclerosis; familial hyperlipidemia; steatotic liver disease; and xanthomatosis. Biomarker of metabolic dysfunction and alcohol associated liver disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LDLR (low density lipoprotein receptor). [provided by Alliance of Genome Resources, May 2025] |
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