Protein Name C-C motif chemokine receptor 2
Organism Homo sapiens
Gene ID 729230
Gene Symbol

CCR2

UniProt P41597 (CCR2_HUMAN), A0A024R2Q0 (A0A024R2Q0_HUMAN)
Relationships Total Number of functionally related compound(s) : 352
Total Number of Articles : 372
Description

C-C motif chemokine receptor 2

Gene Summary

The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3. [provided by RefSeq, Aug 2017]

synonyms
  • C-C chemokine receptor type 2
  • MCP-1 receptor
  • chemokine (C-C motif) receptor 2
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Properties