| Protein Name | TIR domain containing adaptor protein |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 114609 |
| Gene Symbol | TIRAP |
| UniProt | P58753 (TIRAP_HUMAN), A0A024R3M4 (A0A024R3M4_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
32
Total Number of Articles : 27 |
Description |
TIR domain containing adaptor protein |
| Gene Summary |
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008] |
| synonyms |
|
| Properties | |