PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
8021251-8	1994	PP2A catalyzed 32P release from p34cdc2-phosphorylated histone H1.	Phosphorus-32	15-18	cyclin dependent kinase 1	Homo sapiens	32-39
8002990-0	1994	Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275.	Flavonoids	49-58	cyclin dependent kinase 1	Homo sapiens	21-25
8002990-1	1994	L86-8275 [(-) cis-5,7-dihydroxy-2-(2-chlorophenyl)-8[4-(3-hydroxy-1- methyl)-piperidinyl]-4H-benzopyran-4-one] directly inhibits immunoprecipitated Cdc2 kinase activity from G2/M synchronized MDA-MB-468 breast carcinoma cells and is at least 250-fold more potent than either quercetin or genistein.	-2-(2-chlorophenyl)-8[4-(3-	31-58	cyclin dependent kinase 1	Homo sapiens	148-152
8002990-1	1994	L86-8275 [(-) cis-5,7-dihydroxy-2-(2-chlorophenyl)-8[4-(3-hydroxy-1- methyl)-piperidinyl]-4H-benzopyran-4-one] directly inhibits immunoprecipitated Cdc2 kinase activity from G2/M synchronized MDA-MB-468 breast carcinoma cells and is at least 250-fold more potent than either quercetin or genistein.	piperidinyl]-4h-benzopyran-4-one	77-109	cyclin dependent kinase 1	Homo sapiens	148-152
8187833-0	1994	Phorbol ester TPA rapidly prevents activation of p34cdc2 histone H1 kinase and concomitantly the transition from G2 phase to mitosis in synchronized HeLa cells.	Phorbol Esters	0-13	cyclin dependent kinase 1	Homo sapiens	49-56
8187833-0	1994	Phorbol ester TPA rapidly prevents activation of p34cdc2 histone H1 kinase and concomitantly the transition from G2 phase to mitosis in synchronized HeLa cells.	Tetradecanoylphorbol Acetate	14-17	cyclin dependent kinase 1	Homo sapiens	49-56
8187833-4	1994	Treatment of HeLa cells (synchronized around the G2-M transition) with TPA (10(-7) M) has now been shown to induce an overall decrease of the histone H1 kinase activity associated with anti-p34cdc2 immunoprecipitates after about 20 to 30 min.	Tetradecanoylphorbol Acetate	71-74	cyclin dependent kinase 1	Homo sapiens	190-197
8187833-8	1994	However, p34cdc2 from cultures treated with TPA was more intensely stained by anti-phosphotyrosine antibodies than that of control cells, indicating that TPA treatment probably prevented the tyrosine dephosphorylation required for expression of the histone H1 kinase activity of the complex.	Tetradecanoylphorbol Acetate	44-47	cyclin dependent kinase 1	Homo sapiens	9-16
8187833-8	1994	However, p34cdc2 from cultures treated with TPA was more intensely stained by anti-phosphotyrosine antibodies than that of control cells, indicating that TPA treatment probably prevented the tyrosine dephosphorylation required for expression of the histone H1 kinase activity of the complex.	Phosphotyrosine	83-98	cyclin dependent kinase 1	Homo sapiens	9-16
8187833-8	1994	However, p34cdc2 from cultures treated with TPA was more intensely stained by anti-phosphotyrosine antibodies than that of control cells, indicating that TPA treatment probably prevented the tyrosine dephosphorylation required for expression of the histone H1 kinase activity of the complex.	Tetradecanoylphorbol Acetate	154-157	cyclin dependent kinase 1	Homo sapiens	9-16
8187833-8	1994	However, p34cdc2 from cultures treated with TPA was more intensely stained by anti-phosphotyrosine antibodies than that of control cells, indicating that TPA treatment probably prevented the tyrosine dephosphorylation required for expression of the histone H1 kinase activity of the complex.	Tyrosine	90-98	cyclin dependent kinase 1	Homo sapiens	9-16
8187833-9	1994	The results indicate that TPA treatment of HeLa cultures rapidly stops the G2-M transition because it very rapidly prevents the p34cdc2/Cyclin B complex in G2 cells from developing histone H1 kinase activity.	Tetradecanoylphorbol Acetate	26-29	cyclin dependent kinase 1	Homo sapiens	128-135
8157662-3	1994	The amino-terminal domain contains a Ser-Arg-rich stretch and consensus sites for phosphorylation by protein kinase A and p34cdc2 protein kinase.	Serine	37-40	cyclin dependent kinase 1	Homo sapiens	122-129
14731678-1	1994	The phosphotyrosine content of the cdc2 protein kinases, the catalytic component of maturation-promoting factor (MPF), is an important parameter of mitotic regulation in a variety of organisms.	Phosphotyrosine	4-19	cyclin dependent kinase 1	Homo sapiens	35-39
8175758-4	1994	The p15cdk-BP-bound "PSTAIRE signal" is part of a 250-kDa complex distinct from p34cdc2/cyclin B. p15cdk-BP-Sepharose beads retain a kinase phosphorylating HMG I/Y, P1, and myelin basic protein (among 24 substrates tested).	Sepharose	108-117	cyclin dependent kinase 1	Homo sapiens	80-87
8175758-9	1994	cdc2 and cdk2 bind to p9CKShs1-Sepharose, but not to p15cdk-BP.	Sepharose	31-40	cyclin dependent kinase 1	Homo sapiens	0-4
8157662-3	1994	The amino-terminal domain contains a Ser-Arg-rich stretch and consensus sites for phosphorylation by protein kinase A and p34cdc2 protein kinase.	Arginine	41-44	cyclin dependent kinase 1	Homo sapiens	122-129
8135843-0	1994	The protein kinase C inhibitor ilmofosine (BM 41 440) arrests cells in G2 phase and suppresses CDC2 kinase activation through a mechanism different from that of DNA damaging agents.	ilmofosine	31-41	cyclin dependent kinase 1	Homo sapiens	95-99
8041894-4	1994	The mechanism underlying the G2 arrest may involve suppression of cyclin B1 mRNA and/or protein in some cell lines and tyrosine phosphorylation of p34cdc2 in others.	Tyrosine	119-127	cyclin dependent kinase 1	Homo sapiens	147-154
8144611-9	1994	We have produced recombinant p18 in bacterial cells and shown that it can be phosphorylated in vitro by purified p34cdc2 kinase with a stoichiometry of 0.86 mol of PO4/mol of substrate.	po4	164-167	cyclin dependent kinase 1	Homo sapiens	113-120
8144611-10	1994	We have used site-directed mutagenesis to demonstrate that the site of p34cdc2 phosphorylation is the serine at position 38.	Serine	102-108	cyclin dependent kinase 1	Homo sapiens	71-78
8135843-7	1994	Indeed, cdc2 became dephosphorylated and cyclin B1 protein levels decreased as ilmofosine treated cells became arrested in G2.	ilmofosine	79-89	cyclin dependent kinase 1	Homo sapiens	8-12
8135843-8	1994	Our findings suggest that ilmofosine down-regulates cdc2 kinase activation through a mechanism that affects the formation of cdc2/cyclin B1 complexes.	ilmofosine	26-36	cyclin dependent kinase 1	Homo sapiens	52-56
8135843-8	1994	Our findings suggest that ilmofosine down-regulates cdc2 kinase activation through a mechanism that affects the formation of cdc2/cyclin B1 complexes.	ilmofosine	26-36	cyclin dependent kinase 1	Homo sapiens	125-129
8137239-0	1994	Ionizing radiation induces rapid tyrosine phosphorylation of p34cdc2.	Tyrosine	33-41	cyclin dependent kinase 1	Homo sapiens	61-68
8294496-2	1994	It has been reported that cdc2 phosphorylates MLC in vitro at Ser-1 or Ser-2 and Thr-9 which protein kinase C phosphorylates (Satterwhite, L. L., M. J. Lohka, K. L. Wilson, T. Y. Scherson, L. K. Cisek, J. L. Corden, and T. D. Pollard.	Serine	62-65	cyclin dependent kinase 1	Homo sapiens	26-30
8114697-3	1994	MKK1 contains a consensus phosphorylation site for p34cdc2, a serine/threonine protein kinase that regulates the cell division cycle, at Thr-286 and a related site at Thr-292.	Threonine	137-140	cyclin dependent kinase 1	Homo sapiens	51-58
8114697-3	1994	MKK1 contains a consensus phosphorylation site for p34cdc2, a serine/threonine protein kinase that regulates the cell division cycle, at Thr-286 and a related site at Thr-292.	Threonine	167-170	cyclin dependent kinase 1	Homo sapiens	51-58
8114697-4	1994	p34cdc2 catalyzes the in vitro phosphorylation of MKK1 on both of these threonine residues and inactivates MKK1 enzymatic activity.	Threonine	72-81	cyclin dependent kinase 1	Homo sapiens	0-7
10465025-8	1994	These findings indicate that vitamin D3 analogues regulate cell proliferation by control of the transition of G1 and G2+M phases, reminiscent of the cdc2/CDK2 type of cell cycle control.	Cholecalciferol	29-39	cyclin dependent kinase 1	Homo sapiens	149-153
8109984-2	1994	To elucidate how CDDP acts on cell-cycle regulation, we analyzed the effect of CDDP on cell-cycle regulators such as P34cdc2 protein kinase.	Cisplatin	17-21	cyclin dependent kinase 1	Homo sapiens	117-124
8109984-2	1994	To elucidate how CDDP acts on cell-cycle regulation, we analyzed the effect of CDDP on cell-cycle regulators such as P34cdc2 protein kinase.	Cisplatin	79-83	cyclin dependent kinase 1	Homo sapiens	117-124
8109984-6	1994	The activation of p34cdc2 was inhibited by CDDP.	Cisplatin	43-47	cyclin dependent kinase 1	Homo sapiens	18-25
8109984-8	1994	Our data suggested that the effect of CDDP on cell-cycle phase might be regulated by the dephosphorylation of p34cdc2.	Cisplatin	38-42	cyclin dependent kinase 1	Homo sapiens	110-117
8109984-9	1994	We hypothesize that inhibition of p34cdc2 dephosphorylation by CDDP is important for its growth-inhibiting properties.	Cisplatin	63-67	cyclin dependent kinase 1	Homo sapiens	34-41
8294496-2	1994	It has been reported that cdc2 phosphorylates MLC in vitro at Ser-1 or Ser-2 and Thr-9 which protein kinase C phosphorylates (Satterwhite, L. L., M. J. Lohka, K. L. Wilson, T. Y. Scherson, L. K. Cisek, J. L. Corden, and T. D. Pollard.	Threonine	81-84	cyclin dependent kinase 1	Homo sapiens	26-30
8406990-0	1993	Cis-diamminedichloroplatinum(II) inhibits p34cdc2 protein kinase in human lung-cancer cells.	Cisplatin	0-28	cyclin dependent kinase 1	Homo sapiens	42-49
7513215-2	1993	We have found that cyclin B-cdc2 kinase activity drops earlier in emetine-treated than in control starfish oocytes, although the protein synthesis inhibitor does not activate the cyclin degradation pathway prematurely.	Emetine	66-73	cyclin dependent kinase 1	Homo sapiens	28-32
7504471-1	1993	The cdc2-activator cdc25C was immunoprecipitated from HeLa cell extracts and assayed as tyrosine phosphatase (PTP) using tyrosine-phosphorylated myelin basic protein.	Tyrosine	88-96	cyclin dependent kinase 1	Homo sapiens	4-8
7504471-6	1993	cdc25C was also found associated with cdc2-p13-Sepharose complex and its PTP activity was 7-fold higher in samples from mitotic than from asynchronous cells.	Sepharose	47-56	cyclin dependent kinase 1	Homo sapiens	0-4
8406990-10	1993	Our data suggest that the effect of CDDP on cell-cycle phase might be regulated by the dephosphorylation of p34cdc2 protein kinase.	Cisplatin	36-40	cyclin dependent kinase 1	Homo sapiens	108-115
8250970-0	1993	Alteration of the phosphorylation state of p34cdc2 kinase by the flavone L86-8275 in breast carcinoma cells.	flavone	65-72	cyclin dependent kinase 1	Homo sapiens	43-50
8250970-4	1993	L86-8275 inhibited [32P]orthophosphate labeling of p34cdc2 threonine and tyrosine residues and decreased the phosphotyrosine content of p34cdc2.	Phosphorus-32	20-23	cyclin dependent kinase 1	Homo sapiens	51-58
8250970-4	1993	L86-8275 inhibited [32P]orthophosphate labeling of p34cdc2 threonine and tyrosine residues and decreased the phosphotyrosine content of p34cdc2.	Phosphates	24-38	cyclin dependent kinase 1	Homo sapiens	51-58
8250970-4	1993	L86-8275 inhibited [32P]orthophosphate labeling of p34cdc2 threonine and tyrosine residues and decreased the phosphotyrosine content of p34cdc2.	Threonine	59-68	cyclin dependent kinase 1	Homo sapiens	51-58
8250970-4	1993	L86-8275 inhibited [32P]orthophosphate labeling of p34cdc2 threonine and tyrosine residues and decreased the phosphotyrosine content of p34cdc2.	Phosphotyrosine	109-124	cyclin dependent kinase 1	Homo sapiens	136-143
8250970-5	1993	Diminution of p34cdc2 phosphotyrosine appeared selective, as a general depletion of cellular phosphotyrosine was not observed.	Phosphotyrosine	22-37	cyclin dependent kinase 1	Homo sapiens	14-21
8250970-7	1993	[35S]Methionine labeling of p34cdc2 or other cellular proteins was not inhibited at concentrations that were effective for complete cellular growth inhibition.	Sulfur-35	1-4	cyclin dependent kinase 1	Homo sapiens	28-35
8250970-7	1993	[35S]Methionine labeling of p34cdc2 or other cellular proteins was not inhibited at concentrations that were effective for complete cellular growth inhibition.	Methionine	5-15	cyclin dependent kinase 1	Homo sapiens	28-35
8114763-6	1993	Multiple serine and threonine residues are phosphorylated in vivo as well as in vitro by p34cdc2.	Serine	9-15	cyclin dependent kinase 1	Homo sapiens	89-96
8114763-6	1993	Multiple serine and threonine residues are phosphorylated in vivo as well as in vitro by p34cdc2.	Threonine	20-29	cyclin dependent kinase 1	Homo sapiens	89-96
8224153-0	1993	Petunia p34cdc2 protein kinase activity in G2/M cells obtained with a reversible cell cycle inhibitor, mimosine.	Mimosine	103-111	cyclin dependent kinase 1	Homo sapiens	8-15
8406990-11	1993	To determine whether the p34cdc2 protein kinase is a primary target for CDDP, we examined the direct effect of CDDP on tyrosine dephosphorylation of p34cdc2 protein kinase in cellular extracts.	Cisplatin	111-115	cyclin dependent kinase 1	Homo sapiens	149-156
8406990-11	1993	To determine whether the p34cdc2 protein kinase is a primary target for CDDP, we examined the direct effect of CDDP on tyrosine dephosphorylation of p34cdc2 protein kinase in cellular extracts.	Tyrosine	119-127	cyclin dependent kinase 1	Homo sapiens	149-156
8406990-13	1993	In vitro dephosphorylation of phosphotyrosine of p34cdc2 protein kinase was observed after exposure to okadaic acid in a concentration-dependent manner.	Phosphotyrosine	30-45	cyclin dependent kinase 1	Homo sapiens	49-56
8406990-2	1993	To elucidate how CDDP acts on cell-cycle regulation, we analyzed the effect of CDDP on cell-cycle regulators such as p34cdc2 protein kinase.	Cisplatin	17-21	cyclin dependent kinase 1	Homo sapiens	117-124
8406990-13	1993	In vitro dephosphorylation of phosphotyrosine of p34cdc2 protein kinase was observed after exposure to okadaic acid in a concentration-dependent manner.	Okadaic Acid	103-115	cyclin dependent kinase 1	Homo sapiens	49-56
8406990-14	1993	The dephosphorylation of p34cdc2 protein kinase by okadaic acid was inhibited by CDDP.	Okadaic Acid	51-63	cyclin dependent kinase 1	Homo sapiens	25-32
8406990-2	1993	To elucidate how CDDP acts on cell-cycle regulation, we analyzed the effect of CDDP on cell-cycle regulators such as p34cdc2 protein kinase.	Cisplatin	79-83	cyclin dependent kinase 1	Homo sapiens	117-124
8406990-14	1993	The dephosphorylation of p34cdc2 protein kinase by okadaic acid was inhibited by CDDP.	Cisplatin	81-85	cyclin dependent kinase 1	Homo sapiens	25-32
8406990-6	1993	The activation of p34cdc2 protein kinase was inhibited by CDDP.	Cisplatin	58-62	cyclin dependent kinase 1	Homo sapiens	18-25
8406990-15	1993	We hypothesize that inhibition of p34cdc2 dephorphorylation by CDDP is important for its growth-inhibiting properties.	Cisplatin	63-67	cyclin dependent kinase 1	Homo sapiens	34-41
8276402-1	1993	The human CDC25 tyrosine phosphatases trigger activation of CDC2 by removing inhibitory phosphates; thus the genes encoding these phosphatases may be suspected as potential oncogenes due to their role in promoting cell division.	Phosphates	88-98	cyclin dependent kinase 1	Homo sapiens	10-14
8402895-1	1993	Cyclin B-cdc2 complexes are kept inactive by inhibitory phosphorylations on Thr-14 and Tyr-15 of cdc2 until they are dephosphorylated at the end of G2 by the phosphatase cdc25.	Threonine	76-79	cyclin dependent kinase 1	Homo sapiens	9-13
8402895-1	1993	Cyclin B-cdc2 complexes are kept inactive by inhibitory phosphorylations on Thr-14 and Tyr-15 of cdc2 until they are dephosphorylated at the end of G2 by the phosphatase cdc25.	Tyrosine	87-90	cyclin dependent kinase 1	Homo sapiens	9-13
8402895-1	1993	Cyclin B-cdc2 complexes are kept inactive by inhibitory phosphorylations on Thr-14 and Tyr-15 of cdc2 until they are dephosphorylated at the end of G2 by the phosphatase cdc25.	Tyrosine	87-90	cyclin dependent kinase 1	Homo sapiens	97-101
8260651-10	1993	In addition, ligation of the IL-2R leads to rapid increases in myc expression and more delayed increases in the expression of the cdc2 and cdk2 kinases and the cyclins through a tyrosine phosphorylation independent pathway.	Tyrosine	178-186	cyclin dependent kinase 1	Homo sapiens	130-134
8397207-3	1993	Activation of cdk2-catalyzed H1 kinase activity by cyclin A required a 10-min preincubation of the two components, whereas cdc2 kinase supported phosphate incorporation without a detectable time lag upon the addition of cyclin B1, suggesting a slower association rate of cdk2 with cyclin A compared with cdc2 and cyclin B1.	Phosphates	145-154	cyclin dependent kinase 1	Homo sapiens	123-127
8358725-10	1993	Also, DFO-treated cells exhibited a decrease in both p34cdc2 immunoreactive protein as well as kinase activity.	Deferoxamine	6-9	cyclin dependent kinase 1	Homo sapiens	53-60
8397207-4	1993	Both cdk2 and cyclin A, as well as cdc2 and cyclin B1, formed stable complexes in the absence of ATP and substrate that could be isolated after glycerol gradient centrifugation.	Adenosine Triphosphate	97-100	cyclin dependent kinase 1	Homo sapiens	35-39
8397207-4	1993	Both cdk2 and cyclin A, as well as cdc2 and cyclin B1, formed stable complexes in the absence of ATP and substrate that could be isolated after glycerol gradient centrifugation.	Glycerol	144-152	cyclin dependent kinase 1	Homo sapiens	35-39
8373419-3	1993	The result suggests that the N-substituted structure of proline immediately following the site is important for cdc2 kinase phosphorylation.	Nitrogen	29-30	cyclin dependent kinase 1	Homo sapiens	112-116
8373419-3	1993	The result suggests that the N-substituted structure of proline immediately following the site is important for cdc2 kinase phosphorylation.	Proline	56-63	cyclin dependent kinase 1	Homo sapiens	112-116
7689979-7	1993	Consequently also the heptapeptide GEGTYGV reproducing the phosphoacceptor and inhibitory site of p34cdc2 is not appreciably affected by TPK-IIB, unless its threonyl residue is previously phosphorylated, the phosphoderivative GEGTpYGV being readily phosphorylated at its tyrosyl residue.	threonyl	157-165	cyclin dependent kinase 1	Homo sapiens	98-105
8349626-2	1993	Recent evidence from our laboratory indicates that AdPol is a phosphoprotein and that the major in vivo phosphorylation site, serine 67, occurs within the consensus substrate recognition sequence for cdc2 kinases.	adpol	51-56	cyclin dependent kinase 1	Homo sapiens	200-204
8227209-6	1993	Microtubule-bound p34cdc2 and cyclin B were released from microtubules by a high-salt solution and possessed a complex form as shown by the adsorption to suc1-beads and by immunoprecipitation with the anti-cyclin B antibody.	Salts	81-85	cyclin dependent kinase 1	Homo sapiens	18-25
8336738-2	1993	Charged-to-alanine scanning mutagenesis of Cdc2 was used previously to localize cyclin A- and B- and Suc1-binding sites (B. Ducommun, P. Brambilla, and G. Draetta, Mol.	Alanine	11-18	cyclin dependent kinase 1	Homo sapiens	43-47
21573322-4	1993	p34cdc2 is a major tyrosine phosphorylated protein in the S- and G2-phases of both HeLa and CHO cells, although fundamental differences appear to exist in p34cdc2 regulation; approximately 80% of this protein is found in its hyperphosphorylated form in CHO cells compared to a maximum of 30% in HeLa cells.	Tyrosine	19-27	cyclin dependent kinase 1	Homo sapiens	0-7
21573322-5	1993	A brief exposure to etoposide causes both cell lines to arrest in G2, with a concomittant increase in cyclin-B levels and accumulation of hyperphosphorylated p34cdc2.	Etoposide	20-29	cyclin dependent kinase 1	Homo sapiens	158-165
21573322-6	1993	Failure to activate the p34cdc2 kinase following etoposide treatment to levels comparable with synchronous G2/M-phase cells is not due to inhibition of p34cdc2/cyclin-B complex formation, but relies more on an inability to tyrosine dephosphorylate p34cdc2.	Etoposide	49-58	cyclin dependent kinase 1	Homo sapiens	24-31
21573322-6	1993	Failure to activate the p34cdc2 kinase following etoposide treatment to levels comparable with synchronous G2/M-phase cells is not due to inhibition of p34cdc2/cyclin-B complex formation, but relies more on an inability to tyrosine dephosphorylate p34cdc2.	Tyrosine	223-231	cyclin dependent kinase 1	Homo sapiens	24-31
8341696-8	1993	DNA binding also reduces phosphorylation of Jun by casein kinase II, p34cdc2 (cdc2) kinase, and protein kinase C. Phosphorylation of Fos by cAMP-dependent protein kinase and cdc2 is relatively insensitive to dimerization and DNA binding, whereas phosphorylation of Fos and Jun by DNA-dependent protein kinase is dramatically stimulated by binding to the AP-1 site.	Cyclic AMP	140-144	cyclin dependent kinase 1	Homo sapiens	69-76
8341696-8	1993	DNA binding also reduces phosphorylation of Jun by casein kinase II, p34cdc2 (cdc2) kinase, and protein kinase C. Phosphorylation of Fos by cAMP-dependent protein kinase and cdc2 is relatively insensitive to dimerization and DNA binding, whereas phosphorylation of Fos and Jun by DNA-dependent protein kinase is dramatically stimulated by binding to the AP-1 site.	Cyclic AMP	140-144	cyclin dependent kinase 1	Homo sapiens	72-76
8341696-8	1993	DNA binding also reduces phosphorylation of Jun by casein kinase II, p34cdc2 (cdc2) kinase, and protein kinase C. Phosphorylation of Fos by cAMP-dependent protein kinase and cdc2 is relatively insensitive to dimerization and DNA binding, whereas phosphorylation of Fos and Jun by DNA-dependent protein kinase is dramatically stimulated by binding to the AP-1 site.	Cyclic AMP	140-144	cyclin dependent kinase 1	Homo sapiens	78-82
8349626-2	1993	Recent evidence from our laboratory indicates that AdPol is a phosphoprotein and that the major in vivo phosphorylation site, serine 67, occurs within the consensus substrate recognition sequence for cdc2 kinases.	Serine	126-132	cyclin dependent kinase 1	Homo sapiens	200-204
8349626-5	1993	The associated protein kinase and the p34cdc2 kinase phosphorylate AdPol at the same sites which are utilized in vivo, suggesting that the p34cdc2 kinase or a related kinase may be involved in the in vivo phosphorylation of AdPol.	adpol	67-72	cyclin dependent kinase 1	Homo sapiens	38-45
8349626-5	1993	The associated protein kinase and the p34cdc2 kinase phosphorylate AdPol at the same sites which are utilized in vivo, suggesting that the p34cdc2 kinase or a related kinase may be involved in the in vivo phosphorylation of AdPol.	adpol	67-72	cyclin dependent kinase 1	Homo sapiens	139-146
8349626-5	1993	The associated protein kinase and the p34cdc2 kinase phosphorylate AdPol at the same sites which are utilized in vivo, suggesting that the p34cdc2 kinase or a related kinase may be involved in the in vivo phosphorylation of AdPol.	adpol	224-229	cyclin dependent kinase 1	Homo sapiens	38-45
8349626-5	1993	The associated protein kinase and the p34cdc2 kinase phosphorylate AdPol at the same sites which are utilized in vivo, suggesting that the p34cdc2 kinase or a related kinase may be involved in the in vivo phosphorylation of AdPol.	adpol	224-229	cyclin dependent kinase 1	Homo sapiens	139-146
8441405-1	1993	The kinase activity of human p34cdc2 is negatively regulated by phosphorylation at Thr-14 and Tyr-15.	Threonine	83-86	cyclin dependent kinase 1	Homo sapiens	29-36
8334517-0	1993	Phosphorylation of tau by proline-directed protein kinase (p34cdc2/p58cyclin A) decreases tau-induced microtubule assembly and antibody SMI33 reactivity.	Proline	26-33	cyclin dependent kinase 1	Homo sapiens	59-66
8334517-1	1993	Tau protein was evaluated as a substrate for a proline-directed protein kinase (p34cdc2/p58cyclin A) which recognizes the phosphorylation site motif X-Ser/Thr-Pro-X.	Serine	151-154	cyclin dependent kinase 1	Homo sapiens	80-87
8334517-1	1993	Tau protein was evaluated as a substrate for a proline-directed protein kinase (p34cdc2/p58cyclin A) which recognizes the phosphorylation site motif X-Ser/Thr-Pro-X.	Threonine	155-158	cyclin dependent kinase 1	Homo sapiens	80-87
8334517-1	1993	Tau protein was evaluated as a substrate for a proline-directed protein kinase (p34cdc2/p58cyclin A) which recognizes the phosphorylation site motif X-Ser/Thr-Pro-X.	Proline	159-162	cyclin dependent kinase 1	Homo sapiens	80-87
8493533-5	1993	The threonine at residue 490 was phosphorylated by p34cdc2 kinase in vitro; phosphorylation at this site in vivo was associated with rapid degradation of RAG-2.	Threonine	4-13	cyclin dependent kinase 1	Homo sapiens	51-58
8485236-4	1993	The cdc2 and PSTAIRE antibodies also reacted predominantly with the acrosomal regions of human sperm cells in IFT and recognized the specific band of 34 kDa corresponding to p34 cdc2 protein on the Western blot of DOC-solubilized noncapacitated human sperm preparation.	Deoxycholic Acid	214-217	cyclin dependent kinase 1	Homo sapiens	4-8
8485236-4	1993	The cdc2 and PSTAIRE antibodies also reacted predominantly with the acrosomal regions of human sperm cells in IFT and recognized the specific band of 34 kDa corresponding to p34 cdc2 protein on the Western blot of DOC-solubilized noncapacitated human sperm preparation.	Deoxycholic Acid	214-217	cyclin dependent kinase 1	Homo sapiens	174-182
8440392-0	1993	Dephosphorylation of human p34cdc2 kinase on both Thr-14 and Tyr-15 by human cdc25B phosphatase.	Threonine	50-53	cyclin dependent kinase 1	Homo sapiens	27-34
8440392-0	1993	Dephosphorylation of human p34cdc2 kinase on both Thr-14 and Tyr-15 by human cdc25B phosphatase.	Tyrosine	61-64	cyclin dependent kinase 1	Homo sapiens	27-34
8440392-1	1993	In mammalian cells, p34cdc2 kinase undergoes phosphorylation at threonine-14, tyrosine-15 and threonine-161 in the S and G2 phases of the cell cycle.	Threonine	64-73	cyclin dependent kinase 1	Homo sapiens	20-27
8382303-10	1993	Between these two basic amino acid blocks in the nuclear transport signal, at threonine 102, is a putative site for phosphorylation by the cell cycle regulated kinase p34cdc2.	Amino Acids, Basic	18-34	cyclin dependent kinase 1	Homo sapiens	167-174
8382303-10	1993	Between these two basic amino acid blocks in the nuclear transport signal, at threonine 102, is a putative site for phosphorylation by the cell cycle regulated kinase p34cdc2.	Threonine	78-87	cyclin dependent kinase 1	Homo sapiens	167-174
8382303-12	1993	An E1 gene mutant at threonine 102 encodes for a protein which is no longer a substrate for the p34cdc2 kinase.	Threonine	21-30	cyclin dependent kinase 1	Homo sapiens	96-103
8500762-5	1993	The primary sequence of Eh cdc2 is most like those of cdc2 homologues Eg1 of Xenopus laevis and CDK2 of man (52% aa identity with each) and codes for (i) the serine (Ser), threonine (Thr), and tyrosine residues phosphorylated in p34cdc2 proteins, (ii) 32 of 33 aa conserved in other Ser/Thr protein kinases, and (iii) the sequence PVTSVRE instead of PSTAIRE found in most p34cdc2 proteins.	Serine	158-164	cyclin dependent kinase 1	Homo sapiens	229-236
8500762-5	1993	The primary sequence of Eh cdc2 is most like those of cdc2 homologues Eg1 of Xenopus laevis and CDK2 of man (52% aa identity with each) and codes for (i) the serine (Ser), threonine (Thr), and tyrosine residues phosphorylated in p34cdc2 proteins, (ii) 32 of 33 aa conserved in other Ser/Thr protein kinases, and (iii) the sequence PVTSVRE instead of PSTAIRE found in most p34cdc2 proteins.	Serine	158-164	cyclin dependent kinase 1	Homo sapiens	372-379
8463339-0	1993	G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently.	Nitrogen	20-28	cyclin dependent kinase 1	Homo sapiens	88-92
8475101-4	1993	The vertebrate CDC2/cyclin B1 complex is an essential regulator of the onset of mitosis and is inhibited by phosphorylation of CDC2 on Thr-14 and Tyr-15.	Threonine	135-138	cyclin dependent kinase 1	Homo sapiens	15-19
8475101-4	1993	The vertebrate CDC2/cyclin B1 complex is an essential regulator of the onset of mitosis and is inhibited by phosphorylation of CDC2 on Thr-14 and Tyr-15.	Threonine	135-138	cyclin dependent kinase 1	Homo sapiens	127-131
8475101-4	1993	The vertebrate CDC2/cyclin B1 complex is an essential regulator of the onset of mitosis and is inhibited by phosphorylation of CDC2 on Thr-14 and Tyr-15.	Tyrosine	146-149	cyclin dependent kinase 1	Homo sapiens	15-19
8475101-9	1993	Furthermore, our data suggest that the phosphorylation and dephosphorylation of CDKs on Thr-14 and Tyr-15 may regulate not only the G2/M transition but also other transitions in the cell cycle and that individual cdc25 family members may regulate distinct cell cycle checkpoints.	Threonine	88-91	cyclin dependent kinase 1	Homo sapiens	80-84
8440392-1	1993	In mammalian cells, p34cdc2 kinase undergoes phosphorylation at threonine-14, tyrosine-15 and threonine-161 in the S and G2 phases of the cell cycle.	Tyrosine	78-86	cyclin dependent kinase 1	Homo sapiens	20-27
8440392-1	1993	In mammalian cells, p34cdc2 kinase undergoes phosphorylation at threonine-14, tyrosine-15 and threonine-161 in the S and G2 phases of the cell cycle.	Threonine	94-103	cyclin dependent kinase 1	Homo sapiens	20-27
8441405-8	1993	FSBA modification of both tyrosine-phosphorylated and unphosphorylated p34cdc2 was competitively inhibited by ATP, and half-maximal inhibition in each case occurred at approximately 250 microM ATP.	Adenosine Triphosphate	110-113	cyclin dependent kinase 1	Homo sapiens	71-78
8441405-8	1993	FSBA modification of both tyrosine-phosphorylated and unphosphorylated p34cdc2 was competitively inhibited by ATP, and half-maximal inhibition in each case occurred at approximately 250 microM ATP.	Adenosine Triphosphate	193-196	cyclin dependent kinase 1	Homo sapiens	71-78
8441405-9	1993	In addition to being negatively regulated by phosphorylation, the kinase activity of p34cdc2 was positively regulated by the cyclin-dependent phosphorylation of Thr-161.	Threonine	161-164	cyclin dependent kinase 1	Homo sapiens	85-92
8441405-10	1993	Mutation of p34cdc2 at Thr-161 resulted in the formation of an enzymatically inactive p34cdc2/cyclin B complex both in vivo and in vitro.	Threonine	23-26	cyclin dependent kinase 1	Homo sapiens	12-19
8441405-12	1993	Taken together, these results indicate that inhibition of p34cdc2 kinase activity by phosphorylation of Tyr-15 (within the putative ATP binding domain) or by mutation of Thr-161 involves a mechanism other than inhibition of nucleotide binding.	Tyrosine	104-107	cyclin dependent kinase 1	Homo sapiens	58-65
8441405-12	1993	Taken together, these results indicate that inhibition of p34cdc2 kinase activity by phosphorylation of Tyr-15 (within the putative ATP binding domain) or by mutation of Thr-161 involves a mechanism other than inhibition of nucleotide binding.	Adenosine Triphosphate	132-135	cyclin dependent kinase 1	Homo sapiens	58-65
8441405-12	1993	Taken together, these results indicate that inhibition of p34cdc2 kinase activity by phosphorylation of Tyr-15 (within the putative ATP binding domain) or by mutation of Thr-161 involves a mechanism other than inhibition of nucleotide binding.	Threonine	170-173	cyclin dependent kinase 1	Homo sapiens	58-65
8441405-1	1993	The kinase activity of human p34cdc2 is negatively regulated by phosphorylation at Thr-14 and Tyr-15.	Tyrosine	94-97	cyclin dependent kinase 1	Homo sapiens	29-36
8441405-3	1993	It has been proposed that phosphorylation within this motif ablates the binding of ATP to the active site of p34cdc2, thereby inhibiting p34cdc2 kinase activity (K. Gould and P. Nurse, Nature [London] 342:39-44, 1989).	Adenosine Triphosphate	83-86	cyclin dependent kinase 1	Homo sapiens	109-116
8441405-3	1993	It has been proposed that phosphorylation within this motif ablates the binding of ATP to the active site of p34cdc2, thereby inhibiting p34cdc2 kinase activity (K. Gould and P. Nurse, Nature [London] 342:39-44, 1989).	Adenosine Triphosphate	83-86	cyclin dependent kinase 1	Homo sapiens	137-144
8441405-5	1993	The active site of p34cdc2 was specifically modified by the MgATP analog 5"-p-fluorosulfonylbenzoyladenosine (FSBA).	Adenosine Triphosphate	60-65	cyclin dependent kinase 1	Homo sapiens	19-26
8441405-5	1993	The active site of p34cdc2 was specifically modified by the MgATP analog 5"-p-fluorosulfonylbenzoyladenosine (FSBA).	5'-(4-fluorosulfonylbenzoyl)adenosine	73-108	cyclin dependent kinase 1	Homo sapiens	19-26
8441405-5	1993	The active site of p34cdc2 was specifically modified by the MgATP analog 5"-p-fluorosulfonylbenzoyladenosine (FSBA).	5'-(4-fluorosulfonylbenzoyl)adenosine	110-114	cyclin dependent kinase 1	Homo sapiens	19-26
8441405-7	1993	Tyrosine-phosphorylated p34cdc2 was modified by FSBA with a slightly higher Km (241 microM FSBA).	Tyrosine	0-8	cyclin dependent kinase 1	Homo sapiens	24-31
7678776-4	1993	P-Tyr incubation led to activation of cellular protein tyrosine phosphatases resulting in the inhibition of tyrosine phosphorylation of epidermal growth factor receptor as well as of p34cdc2.	O-phospho-L-tyrosine	0-5	cyclin dependent kinase 1	Homo sapiens	183-190
8382492-0	1993	Vitamin K3 inhibits growth of human hepatoma HepG2 cells by decreasing activities of both p34cdc2 kinase and phosphatase.	Vitamin K 3	0-10	cyclin dependent kinase 1	Homo sapiens	90-97
8382492-6	1993	Our results suggest that vitamin K3 inhibits the growth of HepG2 cells via a cell cycle progression delay and altered phosphorylation patterns and activities of both p34cdc2 kinase and protein-tyrosine phosphatase.	Vitamin K 3	25-35	cyclin dependent kinase 1	Homo sapiens	166-173
8439342-0	1993	cdc2 kinase phosphorylation of desmin at three serine/threonine residues in the amino-terminal head domain.	Serine	47-53	cyclin dependent kinase 1	Homo sapiens	0-4
8439342-0	1993	cdc2 kinase phosphorylation of desmin at three serine/threonine residues in the amino-terminal head domain.	Threonine	54-63	cyclin dependent kinase 1	Homo sapiens	0-4
8439342-2	1993	Sequence analysis of purified phosphopeptides derived from cdc2 kinase-phosphorylated desmin revealed that Ser-6, Ser-22 and Thr-64 in the N-terminal head domain were the sites phosphorylated.	Serine	107-110	cyclin dependent kinase 1	Homo sapiens	59-63
8439342-2	1993	Sequence analysis of purified phosphopeptides derived from cdc2 kinase-phosphorylated desmin revealed that Ser-6, Ser-22 and Thr-64 in the N-terminal head domain were the sites phosphorylated.	Serine	114-117	cyclin dependent kinase 1	Homo sapiens	59-63
8439342-2	1993	Sequence analysis of purified phosphopeptides derived from cdc2 kinase-phosphorylated desmin revealed that Ser-6, Ser-22 and Thr-64 in the N-terminal head domain were the sites phosphorylated.	Threonine	125-128	cyclin dependent kinase 1	Homo sapiens	59-63
7678776-4	1993	P-Tyr incubation led to activation of cellular protein tyrosine phosphatases resulting in the inhibition of tyrosine phosphorylation of epidermal growth factor receptor as well as of p34cdc2.	Tyrosine	55-63	cyclin dependent kinase 1	Homo sapiens	183-190
1279696-1	1992	Recent studies have shown that there exists a family of protein kinases structurally and functionally related to the yeast cell cycle regulatory kinase cdc2 [Meyerson, M., Faha, B., Su, L.-K., Harlow, E. & Tsai, L.-H. (1991) Cold Spring Harbor Symp.	Adenosine Monophosphate	205-208	cyclin dependent kinase 1	Homo sapiens	152-156
8440323-11	1993	It therefore appears that synthesis of p34cdc2 requires a low amount of iron, a finding which may define a possible regulatory point in the cell cycle for iron before its well-recognized role in regulating S phase entry by acting as a cofactor for the enzyme ribonucleotide reductase.	Iron	72-76	cyclin dependent kinase 1	Homo sapiens	39-46
8440323-11	1993	It therefore appears that synthesis of p34cdc2 requires a low amount of iron, a finding which may define a possible regulatory point in the cell cycle for iron before its well-recognized role in regulating S phase entry by acting as a cofactor for the enzyme ribonucleotide reductase.	Iron	155-159	cyclin dependent kinase 1	Homo sapiens	39-46
1423313-3	1992	Expression of the growth-related genes histone H4, cyclin A and B, and p34cdc2 was suppressed in cells blocked with quercetin.	Quercetin	116-125	cyclin dependent kinase 1	Homo sapiens	71-78
1429606-1	1992	The primary sequence of the microtubule-associated protein tau contains multiple repeats of the sequence -X-Ser/Thr-Pro-X-, the consensus sequence for the proline-directed protein kinase (p34cdc2/p58cyclin A).	Serine	108-111	cyclin dependent kinase 1	Homo sapiens	188-195
1429606-1	1992	The primary sequence of the microtubule-associated protein tau contains multiple repeats of the sequence -X-Ser/Thr-Pro-X-, the consensus sequence for the proline-directed protein kinase (p34cdc2/p58cyclin A).	Threonine	112-115	cyclin dependent kinase 1	Homo sapiens	188-195
1429606-1	1992	The primary sequence of the microtubule-associated protein tau contains multiple repeats of the sequence -X-Ser/Thr-Pro-X-, the consensus sequence for the proline-directed protein kinase (p34cdc2/p58cyclin A).	Proline	116-119	cyclin dependent kinase 1	Homo sapiens	188-195
1396589-5	1992	Replacement of T160 with alanine abolishes the kinase activity of CDK2, indicating that phosphorylation at this site (as in CDC2) is required for kinase activity.	Acid Red 374	15-19	cyclin dependent kinase 1	Homo sapiens	124-128
1396589-5	1992	Replacement of T160 with alanine abolishes the kinase activity of CDK2, indicating that phosphorylation at this site (as in CDC2) is required for kinase activity.	Alanine	25-32	cyclin dependent kinase 1	Homo sapiens	124-128
8416202-3	1993	When the cells were arrested in mitotic metaphase by the use of nocodazole, p34cdc2 kinase activity was induced and p53 was apparently phosphorylated.	Nocodazole	64-74	cyclin dependent kinase 1	Homo sapiens	76-83
8443411-2	1993	Recent evidence indicates that cyclin-dependent kinase 2 (Cdk2), like its homolog Cdc2, requires cyclin binding and phosphorylation (of threonine-160) for activation in vivo.	Threonine	136-145	cyclin dependent kinase 1	Homo sapiens	82-86
1279696-15	1992	58, 1365-1371] that cdk1 kinase, but not other structurally defined protein kinases, could phosphorylate the repeated Lys-Ser-Pro (KSP) motifs found in mammalian high and middle molecular mass neurofilament subunits in vitro, but the precise molecular nature of the endogenous neuronal KSP kinase has remained undefined.	Lys-Ser-Pro	118-129	cyclin dependent kinase 1	Homo sapiens	20-24
1279696-15	1992	58, 1365-1371] that cdk1 kinase, but not other structurally defined protein kinases, could phosphorylate the repeated Lys-Ser-Pro (KSP) motifs found in mammalian high and middle molecular mass neurofilament subunits in vitro, but the precise molecular nature of the endogenous neuronal KSP kinase has remained undefined.	[(1R,2S)-2-(2-hydroxybenzene-1-carbonyl)cyclopentyl]acetic acid	131-134	cyclin dependent kinase 1	Homo sapiens	20-24
1340123-0	1992	Cell cycle effects of microinjected antisense oligodeoxynucleotides to p34cdc2 kinase.	Oligodeoxyribonucleotides	46-67	cyclin dependent kinase 1	Homo sapiens	71-78
1437147-3	1992	The kinase domains are approximately 50-55% homologous to members of the cdc2/CDC28 kinase gene family, and each contains a cysteine-for-serine substitution within the conserved PSTAIRE motif.	Cysteine	124-132	cyclin dependent kinase 1	Homo sapiens	73-77
1437147-3	1992	The kinase domains are approximately 50-55% homologous to members of the cdc2/CDC28 kinase gene family, and each contains a cysteine-for-serine substitution within the conserved PSTAIRE motif.	Serine	137-143	cyclin dependent kinase 1	Homo sapiens	73-77
1340123-12	1992	The effects observed with antisense oligomers to p34cdc2 kinase are strikingly similar to what is observed when low concentrations of the drug cycloheximide are added to these cells at different times after serum stimulation; entry into S-phase is significantly inhibited when cycloheximide is added up to 12 hours postimulation.	Cycloheximide	143-156	cyclin dependent kinase 1	Homo sapiens	49-56
1340123-12	1992	The effects observed with antisense oligomers to p34cdc2 kinase are strikingly similar to what is observed when low concentrations of the drug cycloheximide are added to these cells at different times after serum stimulation; entry into S-phase is significantly inhibited when cycloheximide is added up to 12 hours postimulation.	Cycloheximide	277-290	cyclin dependent kinase 1	Homo sapiens	49-56
1400350-7	1992	In addition, phosphorylation at Ser39 also occurs in vivo, since p34cdc2 is phosphorylated during G1 on serine, and its two-dimensional tryptic map shows two phosphopeptides that comigrate exactly with the synthetic peptides used as standard.	Serine	104-110	cyclin dependent kinase 1	Homo sapiens	65-72
1400409-4	1992	The key to the purification procedures we used was buffer containing 0.5 M NaCl and 50% ethylene glycol, as a specific elutant of p34cdc2 kinase from p13suc1-Sepharose.	Sodium Chloride	75-79	cyclin dependent kinase 1	Homo sapiens	130-137
1400409-4	1992	The key to the purification procedures we used was buffer containing 0.5 M NaCl and 50% ethylene glycol, as a specific elutant of p34cdc2 kinase from p13suc1-Sepharose.	Ethylene Glycol	88-103	cyclin dependent kinase 1	Homo sapiens	130-137
1400409-4	1992	The key to the purification procedures we used was buffer containing 0.5 M NaCl and 50% ethylene glycol, as a specific elutant of p34cdc2 kinase from p13suc1-Sepharose.	Sepharose	158-167	cyclin dependent kinase 1	Homo sapiens	130-137
1390903-4	1992	Cells arrested in late G1 by aphidicolin have abundant p58cyclin A and phosphorylated p34cdc2.	Aphidicolin	29-40	cyclin dependent kinase 1	Homo sapiens	86-93
1400350-7	1992	In addition, phosphorylation at Ser39 also occurs in vivo, since p34cdc2 is phosphorylated during G1 on serine, and its two-dimensional tryptic map shows two phosphopeptides that comigrate exactly with the synthetic peptides used as standard.	Peptides	165-173	cyclin dependent kinase 1	Homo sapiens	65-72
1512249-8	1992	The identities of the Rb kinases are unknown, but recent evidence suggests that the cdc2 gene product could participate in Rb phosphorylation.	Rubidium	22-24	cyclin dependent kinase 1	Homo sapiens	84-88
1384126-5	1992	The human WEE1 kinase phosphorylated the p34cdc2-cyclin B complex on tyrosine 15 but not on threonine 14 in vitro and inactivated the p34cdc2-cyclin B kinase.	Tyrosine	69-77	cyclin dependent kinase 1	Homo sapiens	41-48
1384126-5	1992	The human WEE1 kinase phosphorylated the p34cdc2-cyclin B complex on tyrosine 15 but not on threonine 14 in vitro and inactivated the p34cdc2-cyclin B kinase.	Tyrosine	69-77	cyclin dependent kinase 1	Homo sapiens	134-141
1384126-7	1992	These results indicate that the product of the WEE1Hu gene directly regulates the p34cdc2-cyclin B complex in human cells and that a kinase other than that encoded by WEE1Hu phosphorylates p34cdc2 on threonine 14.	Threonine	200-209	cyclin dependent kinase 1	Homo sapiens	189-196
1406653-7	1992	Two of the sites of phosphorylation by cyclic AMP (cAMP)-dependent kinase were localized to serine residues 490 and 499, and one site of phosphorylation by p34cdc2 was localized to serine 484.	Serine	181-187	cyclin dependent kinase 1	Homo sapiens	156-163
1512249-11	1992	The suppression of Rb phosphorylation is suggested to be mediated through inhibition of cdc2 kinase activity by TGF-beta.	Rubidium	19-21	cyclin dependent kinase 1	Homo sapiens	88-92
1382465-6	1992	Oil-isolated oocyte nuclei retain many in vivo functions for several hours, including size-selective envelope permeability, RNA synthesis and the ability to break down in response to cdc2/cyclin meiotic maturation promoting factor.	Oils	0-3	cyclin dependent kinase 1	Homo sapiens	183-187
1321030-0	1992	Dephosphorylation of cdc2 on threonine 161 is required for cdc2 kinase inactivation and normal anaphase.	Threonine	29-38	cyclin dependent kinase 1	Homo sapiens	21-25
1379736-1	1992	Phosphorylation of pp60c-src by p34cdc2 at three amino-proximal serine/threonine residues is temporally correlated with, but insufficient for, mitotic activation of c-Src kinase.	Serine	64-70	cyclin dependent kinase 1	Homo sapiens	32-39
1379736-1	1992	Phosphorylation of pp60c-src by p34cdc2 at three amino-proximal serine/threonine residues is temporally correlated with, but insufficient for, mitotic activation of c-Src kinase.	Threonine	71-80	cyclin dependent kinase 1	Homo sapiens	32-39
1379736-4	1992	We conclude that p34cdc2 partially activates pp60c-src by a two-step process in which its serine/threonine phosphorylations either sensitize pp60c-src to a Tyr-527 phosphatase or desensitize it to a Tyr-527 kinase.	Serine	90-96	cyclin dependent kinase 1	Homo sapiens	17-24
1379736-4	1992	We conclude that p34cdc2 partially activates pp60c-src by a two-step process in which its serine/threonine phosphorylations either sensitize pp60c-src to a Tyr-527 phosphatase or desensitize it to a Tyr-527 kinase.	Threonine	97-106	cyclin dependent kinase 1	Homo sapiens	17-24
1379736-4	1992	We conclude that p34cdc2 partially activates pp60c-src by a two-step process in which its serine/threonine phosphorylations either sensitize pp60c-src to a Tyr-527 phosphatase or desensitize it to a Tyr-527 kinase.	Tyrosine	156-159	cyclin dependent kinase 1	Homo sapiens	17-24
1379736-4	1992	We conclude that p34cdc2 partially activates pp60c-src by a two-step process in which its serine/threonine phosphorylations either sensitize pp60c-src to a Tyr-527 phosphatase or desensitize it to a Tyr-527 kinase.	Tyrosine	199-202	cyclin dependent kinase 1	Homo sapiens	17-24
1629192-6	1992	This result suggests that serine 209 is a likely physiological target for p34cdc2.	Serine	26-32	cyclin dependent kinase 1	Homo sapiens	74-81
1390335-0	1992	12-O-tetradecanoylphorbol-13-acetate induces transient cell cycle arrest in G1 and G2 in metastatic melanoma cells: inhibition of phosphorylation of p34cdc2.	Tetradecanoylphorbol Acetate	0-36	cyclin dependent kinase 1	Homo sapiens	149-156
1390335-4	1992	In addition, TPA induced a pronounced morphological change, which peaked by 1 h and gradually subsided over 24 h. In populations of cells synchronized in G1 using lovastatin, (a) addition of TPA blocked the onset of DNA synthesis up to the end of G1; (b) the lag between addition of the drug and onset of DNA synthesis was less than 30 min; and (c) addition of TPA at the end of G1 prevented the increased phosphorylation of p34cdc2, as determined by immunoprecipitation.	Tetradecanoylphorbol Acetate	13-16	cyclin dependent kinase 1	Homo sapiens	425-432
1390335-4	1992	In addition, TPA induced a pronounced morphological change, which peaked by 1 h and gradually subsided over 24 h. In populations of cells synchronized in G1 using lovastatin, (a) addition of TPA blocked the onset of DNA synthesis up to the end of G1; (b) the lag between addition of the drug and onset of DNA synthesis was less than 30 min; and (c) addition of TPA at the end of G1 prevented the increased phosphorylation of p34cdc2, as determined by immunoprecipitation.	Tetradecanoylphorbol Acetate	191-194	cyclin dependent kinase 1	Homo sapiens	425-432
1390335-4	1992	In addition, TPA induced a pronounced morphological change, which peaked by 1 h and gradually subsided over 24 h. In populations of cells synchronized in G1 using lovastatin, (a) addition of TPA blocked the onset of DNA synthesis up to the end of G1; (b) the lag between addition of the drug and onset of DNA synthesis was less than 30 min; and (c) addition of TPA at the end of G1 prevented the increased phosphorylation of p34cdc2, as determined by immunoprecipitation.	Tetradecanoylphorbol Acetate	191-194	cyclin dependent kinase 1	Homo sapiens	425-432
1321030-0	1992	Dephosphorylation of cdc2 on threonine 161 is required for cdc2 kinase inactivation and normal anaphase.	Threonine	29-38	cyclin dependent kinase 1	Homo sapiens	59-63
1319927-3	1992	Correlation between PP1 activation and I2 phosphorylation is suggested by the fact that both activation and phosphorylation (a) increase in parallel during incubation with cdc2, (b) decrease in parallel upon subsequent cdc2 inhibition by EDTA, and (c) are inhibited by the cdc2 inhibitor 5,6-dichlorobenzimidazole riboside.	Edetic Acid	238-242	cyclin dependent kinase 1	Homo sapiens	172-176
1534950-3	1992	We now report that both Ser-89 and Ser-219, the major E1A phosphorylation site, were phosphorylated in vitro by p34cdc2 purified from HeLa cells.	Serine	24-27	cyclin dependent kinase 1	Homo sapiens	112-119
1534950-3	1992	We now report that both Ser-89 and Ser-219, the major E1A phosphorylation site, were phosphorylated in vitro by p34cdc2 purified from HeLa cells.	Serine	35-38	cyclin dependent kinase 1	Homo sapiens	112-119
1320411-0	1992	Identification of epidermal growth factor Thr-669 phosphorylation site peptide kinases as distinct MAP kinases and p34cdc2.	Threonine	42-45	cyclin dependent kinase 1	Homo sapiens	115-122
1319927-3	1992	Correlation between PP1 activation and I2 phosphorylation is suggested by the fact that both activation and phosphorylation (a) increase in parallel during incubation with cdc2, (b) decrease in parallel upon subsequent cdc2 inhibition by EDTA, and (c) are inhibited by the cdc2 inhibitor 5,6-dichlorobenzimidazole riboside.	Edetic Acid	238-242	cyclin dependent kinase 1	Homo sapiens	219-223
1319927-3	1992	Correlation between PP1 activation and I2 phosphorylation is suggested by the fact that both activation and phosphorylation (a) increase in parallel during incubation with cdc2, (b) decrease in parallel upon subsequent cdc2 inhibition by EDTA, and (c) are inhibited by the cdc2 inhibitor 5,6-dichlorobenzimidazole riboside.	Edetic Acid	238-242	cyclin dependent kinase 1	Homo sapiens	219-223
1319927-3	1992	Correlation between PP1 activation and I2 phosphorylation is suggested by the fact that both activation and phosphorylation (a) increase in parallel during incubation with cdc2, (b) decrease in parallel upon subsequent cdc2 inhibition by EDTA, and (c) are inhibited by the cdc2 inhibitor 5,6-dichlorobenzimidazole riboside.	Dichlororibofuranosylbenzimidazole	288-322	cyclin dependent kinase 1	Homo sapiens	172-176
1319927-3	1992	Correlation between PP1 activation and I2 phosphorylation is suggested by the fact that both activation and phosphorylation (a) increase in parallel during incubation with cdc2, (b) decrease in parallel upon subsequent cdc2 inhibition by EDTA, and (c) are inhibited by the cdc2 inhibitor 5,6-dichlorobenzimidazole riboside.	Dichlororibofuranosylbenzimidazole	288-322	cyclin dependent kinase 1	Homo sapiens	219-223
1319927-3	1992	Correlation between PP1 activation and I2 phosphorylation is suggested by the fact that both activation and phosphorylation (a) increase in parallel during incubation with cdc2, (b) decrease in parallel upon subsequent cdc2 inhibition by EDTA, and (c) are inhibited by the cdc2 inhibitor 5,6-dichlorobenzimidazole riboside.	Dichlororibofuranosylbenzimidazole	288-322	cyclin dependent kinase 1	Homo sapiens	219-223
1376245-7	1992	By contrast, other proline directed Ser/Thr kinases such as p34(cdc2) combined with cyclin A or B have only minor effects on tau phosphorylation.	Proline	19-26	cyclin dependent kinase 1	Homo sapiens	64-68
1375114-3	1992	The treatment of CD34+ cells with HB24 AS oligonucleotides also reduced the levels of c-fos, c-myc, c-myb, cyclin B, and p34cdc2 messenger RNAs compared with cells treated with control oligonucleotides.	Oligonucleotides	42-58	cyclin dependent kinase 1	Homo sapiens	121-128
1318195-4	1992	This purified kinase, and a closely related cyclin A associated cdc2-like kinase, phosphorylated RPA p34 on a subset of the chymotryptic peptides that were phosphorylated in vivo at the G1-S transition.	Peptides	137-145	cyclin dependent kinase 1	Homo sapiens	64-68
1318195-5	1992	Two serines near the N-terminus of RPA p34 were identified as possible sites of phosphorylation by cdc2 kinase.	Serine	4-11	cyclin dependent kinase 1	Homo sapiens	99-103
1644056-11	1992	Moreover, endomembrane traffic is arrested by a cdc2-like kinase probably via phosphorylation of members of the rab protein family which contributes to vesiculation and membrane transport by hydrolyzing GTP (Tuomikoski, T., et al., Nature 342, 942-945 (1989)).	Guanosine Triphosphate	203-206	cyclin dependent kinase 1	Homo sapiens	48-52
1320360-2	1992	In late G2, it is present as an inactive complex of tyrosine-phosphorylated p34cdc2 and unphosphorylated cyclin Bcdc13.	Tyrosine	52-60	cyclin dependent kinase 1	Homo sapiens	76-83
1587853-5	1992	The molar ratio of incorporated phosphate/rap1GAP was approximately 3 by cAMP-dependent kinase and 2 by p34cdc2.	Phosphates	32-41	cyclin dependent kinase 1	Homo sapiens	104-111
1320360-3	1992	In M phase, its activation as an active MPF displaying histone H1 kinase activity originates from the specific tyrosine dephosphorylation of the p34cdc2 subunit by the tyrosine phosphatase p80cdc25.	Tyrosine	111-119	cyclin dependent kinase 1	Homo sapiens	145-152
1551112-0	1992	Inhibition of p34cdc2 kinase activation, p34cdc2 tyrosine dephosphorylation, and mitotic progression in Chinese hamster ovary cells exposed to etoposide.	Tyrosine	49-57	cyclin dependent kinase 1	Homo sapiens	41-48
1315324-7	1992	Approximately 6-12 hours after treatment with okadaic acid, mRNA levels of c-myc, p34cdc2, and p58GTA, two cell cycle regulated protein kinases, decrease.	Okadaic Acid	46-58	cyclin dependent kinase 1	Homo sapiens	82-89
1451779-2	1992	Two series of synthetic peptides that reproduce the amino- and carboxyl-terminal segments of the beta-subunit of casein kinase-2, including the sites phosphorylated by CK2 and cdc2 kinase, respectively, have been used as model substrates for these enzymes.	Peptides	24-32	cyclin dependent kinase 1	Homo sapiens	176-180
1451779-4	1992	The opposite is true of the C-terminal peptide beta(206-215), NFKSPVKTIR, whose Ser-4 is a good target for cdc2 while being unaffected by CK2.	Serine	80-83	cyclin dependent kinase 1	Homo sapiens	107-111
1451779-5	1992	The individual substitutions of Pro-5 and Lys-7 in the latter peptide with Gly and Ala (or Glu), respectively, prevent its phosphorylation by cdc2, whereas the substitution of Lys-3 with Ala is well tolerated and the substitution of the target Ser with Thr actually improves phosphorylation.	Proline	32-35	cyclin dependent kinase 1	Homo sapiens	142-146
1451779-5	1992	The individual substitutions of Pro-5 and Lys-7 in the latter peptide with Gly and Ala (or Glu), respectively, prevent its phosphorylation by cdc2, whereas the substitution of Lys-3 with Ala is well tolerated and the substitution of the target Ser with Thr actually improves phosphorylation.	Lysine	42-45	cyclin dependent kinase 1	Homo sapiens	142-146
1451779-5	1992	The individual substitutions of Pro-5 and Lys-7 in the latter peptide with Gly and Ala (or Glu), respectively, prevent its phosphorylation by cdc2, whereas the substitution of Lys-3 with Ala is well tolerated and the substitution of the target Ser with Thr actually improves phosphorylation.	Peptides	62-69	cyclin dependent kinase 1	Homo sapiens	142-146
1451779-5	1992	The individual substitutions of Pro-5 and Lys-7 in the latter peptide with Gly and Ala (or Glu), respectively, prevent its phosphorylation by cdc2, whereas the substitution of Lys-3 with Ala is well tolerated and the substitution of the target Ser with Thr actually improves phosphorylation.	Glycine	75-78	cyclin dependent kinase 1	Homo sapiens	142-146
1451779-5	1992	The individual substitutions of Pro-5 and Lys-7 in the latter peptide with Gly and Ala (or Glu), respectively, prevent its phosphorylation by cdc2, whereas the substitution of Lys-3 with Ala is well tolerated and the substitution of the target Ser with Thr actually improves phosphorylation.	Alanine	83-86	cyclin dependent kinase 1	Homo sapiens	142-146
1451779-5	1992	The individual substitutions of Pro-5 and Lys-7 in the latter peptide with Gly and Ala (or Glu), respectively, prevent its phosphorylation by cdc2, whereas the substitution of Lys-3 with Ala is well tolerated and the substitution of the target Ser with Thr actually improves phosphorylation.	Glutamic Acid	91-94	cyclin dependent kinase 1	Homo sapiens	142-146
1312900-0	1992	The involvement of active DNA synthesis in camptothecin-induced G2 arrest: altered regulation of p34cdc2/cyclin B.	Camptothecin	43-55	cyclin dependent kinase 1	Homo sapiens	97-104
1312900-3	1992	Brief camptothecin treatment of early S-phase HeLa cells caused arrest at G2 phase and abolished the activation of p34cdc2 protein kinase.	Camptothecin	6-18	cyclin dependent kinase 1	Homo sapiens	115-122
1312900-4	1992	Both tyrosine dephosphorylation of p34cdc2 and cyclin B accumulation were altered.	Tyrosine	5-13	cyclin dependent kinase 1	Homo sapiens	35-42
1535244-6	1992	CDC2 activation by cyclin B1 was studied in detail and was found to be accompanied by phosphorylation of CDC2 on Threonine 161.	Threonine	113-122	cyclin dependent kinase 1	Homo sapiens	0-4
1535244-6	1992	CDC2 activation by cyclin B1 was studied in detail and was found to be accompanied by phosphorylation of CDC2 on Threonine 161.	Threonine	113-122	cyclin dependent kinase 1	Homo sapiens	105-109
1535244-8	1992	Highly purified CDC2 and cyclin B1 also formed inactive complexes that could be activated in an ATP-dependent fashion by unidentified components in crude cell extracts.	Adenosine Triphosphate	96-99	cyclin dependent kinase 1	Homo sapiens	16-20
1567459-0	1992	Staurosporine is a potent inhibitor of p34cdc2 and p34cdc2-like kinases.	Staurosporine	0-13	cyclin dependent kinase 1	Homo sapiens	39-46
1567459-0	1992	Staurosporine is a potent inhibitor of p34cdc2 and p34cdc2-like kinases.	Staurosporine	0-13	cyclin dependent kinase 1	Homo sapiens	51-58
1567459-3	1992	In the present study, we show that staurosporine inhibits the activity of fractionated p34cdc2 and p34cdc2-like kinases with IC50 values of 4-5 nM.	Staurosporine	35-48	cyclin dependent kinase 1	Homo sapiens	87-94
1567459-3	1992	In the present study, we show that staurosporine inhibits the activity of fractionated p34cdc2 and p34cdc2-like kinases with IC50 values of 4-5 nM.	Staurosporine	35-48	cyclin dependent kinase 1	Homo sapiens	99-106
1567459-4	1992	We propose that the G2 phase arrest in the cell cycle caused by staurosporine is due, at least in part, to the inhibition of the p34cdc2 kinases.	Staurosporine	64-77	cyclin dependent kinase 1	Homo sapiens	129-136
1551112-0	1992	Inhibition of p34cdc2 kinase activation, p34cdc2 tyrosine dephosphorylation, and mitotic progression in Chinese hamster ovary cells exposed to etoposide.	Etoposide	143-152	cyclin dependent kinase 1	Homo sapiens	14-21
1313364-0	1992	Specificity of the polycation-stimulated (type-2A) and ATP,Mg-dependent (type-1) protein phosphatases toward substrates phosphorylated by P34cdc2 kinase.	Adenosine Triphosphate	55-58	cyclin dependent kinase 1	Homo sapiens	138-145
1551112-0	1992	Inhibition of p34cdc2 kinase activation, p34cdc2 tyrosine dephosphorylation, and mitotic progression in Chinese hamster ovary cells exposed to etoposide.	Etoposide	143-152	cyclin dependent kinase 1	Homo sapiens	41-48
1551112-1	1992	p34cdc2 kinase, an enzyme essential for mitosis in mammalian cells, may play a role in etoposide-induced G2 phase arrest of Chinese hamster ovary cells.	Etoposide	87-96	cyclin dependent kinase 1	Homo sapiens	0-7
1551112-2	1992	In this study, etoposide is shown to cause inhibition of a specific p34cdc2 kinase activation pathway, that of tyrosine dephosphorylation.	Etoposide	15-24	cyclin dependent kinase 1	Homo sapiens	68-75
1551112-2	1992	In this study, etoposide is shown to cause inhibition of a specific p34cdc2 kinase activation pathway, that of tyrosine dephosphorylation.	Tyrosine	111-119	cyclin dependent kinase 1	Homo sapiens	68-75
1551112-3	1992	Exposure of asynchronously dividing cells to etoposide caused a simultaneous rapid decline of both mitotic index and p34cdc2 kinase activity, suggesting that the kinase was not activated and that the arrest point was in late G2 phase.	Etoposide	45-54	cyclin dependent kinase 1	Homo sapiens	117-124
1551112-5	1992	Activation of the kinase and the onset of mitosis were accompanied by increased electrophoretic mobility and tyrosine dephosphorylation of the p34cdc2 protein.	Tyrosine	109-117	cyclin dependent kinase 1	Homo sapiens	143-150
1551112-6	1992	A 1-h exposure to etoposide during early G2 phase inhibited p34cdc2 kinase activation, its shift in electrophoretic mobility, and its tyrosine dephosphorylation, all of which correlated with a delay in mitotic progression.	Etoposide	18-27	cyclin dependent kinase 1	Homo sapiens	60-67
1551112-8	1992	These data suggest that mammalian cells express a DNA damage-responsive mechanism which controls mitotic progression at the level of p34cdc2 tyrosine dephosphorylation.	Tyrosine	141-149	cyclin dependent kinase 1	Homo sapiens	133-140
1731250-3	1992	In the fission yeast Schizosaccharomyces pombe, mutations that interfere with the phosphorylation of tyrosine 15 (Y15) of p34cdc2, the protein kinase subunit of maturation promoting factor, accelerate the entry into mitosis and abolish the ability of unreplicated DNA to arrest cells in G2.	Tyrosine	101-109	cyclin dependent kinase 1	Homo sapiens	122-129
1371461-8	1992	These results suggest that other changes in serine/threonine protein phosphorylation besides those involved in activation of cdc2 as a histone H1 kinase may be necessary for proper G2-M transition.	Serine	44-50	cyclin dependent kinase 1	Homo sapiens	125-129
1371461-8	1992	These results suggest that other changes in serine/threonine protein phosphorylation besides those involved in activation of cdc2 as a histone H1 kinase may be necessary for proper G2-M transition.	Threonine	51-60	cyclin dependent kinase 1	Homo sapiens	125-129
1386764-4	1992	Furthermore, cells synchronized in late G1 by exposure to the drug mimosine contain active cyclin A/p34 CDC2 kinase, indicating that p34 CDC2 activation can occur before DNA synthesis begins.	Mimosine	67-75	cyclin dependent kinase 1	Homo sapiens	104-108
1386764-4	1992	Furthermore, cells synchronized in late G1 by exposure to the drug mimosine contain active cyclin A/p34 CDC2 kinase, indicating that p34 CDC2 activation can occur before DNA synthesis begins.	Mimosine	67-75	cyclin dependent kinase 1	Homo sapiens	137-141
1737801-11	1992	Interestingly, both phosphoserines are in a very similar sequence context, suggesting that a single proline-directed serine protein kinase, possibly p34cdc2, is responsible for phosphorylation of both sites in vivo.	Phosphoserine	20-34	cyclin dependent kinase 1	Homo sapiens	149-156
1731250-4	1992	Because the tyrosine phosphorylation of p34cdc2 is conserved in S. pombe, Xenopus, chicken and human cells, the regulation of p34cdc2-Y15 phosphorylation could be a universal mechanism mediating the S-phase feedback control and regulating the initiation of mitosis.	Tyrosine	12-20	cyclin dependent kinase 1	Homo sapiens	40-47
1731250-4	1992	Because the tyrosine phosphorylation of p34cdc2 is conserved in S. pombe, Xenopus, chicken and human cells, the regulation of p34cdc2-Y15 phosphorylation could be a universal mechanism mediating the S-phase feedback control and regulating the initiation of mitosis.	Tyrosine	12-20	cyclin dependent kinase 1	Homo sapiens	126-133
1534688-0	1992	Relationships between cdc2 kinase, DNA cross-linking, and cell cycle perturbations induced by nitrogen mustard.	Nitrogen	94-102	cyclin dependent kinase 1	Homo sapiens	22-26
1731328-0	1992	Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis.	Oligodeoxyribonucleotides	22-42	cyclin dependent kinase 1	Homo sapiens	76-80
1731328-4	1992	The CHED protein includes the consensus ATP binding and phosphorylation domains characteristic of kinases, displays 34-42% identically aligned amino acid residues with other cdc2-related kinases, and is considerably longer at its amino and carboxyl termini.	Adenosine Triphosphate	40-43	cyclin dependent kinase 1	Homo sapiens	174-178
1731328-8	1992	In contrast, an oligodeoxynucleotide blocking production of the human 2Hs cdc2 homolog interfered with production of the human 2Hs cdc2 homolog interfered with cellular proliferation without altering the cell-type composition of these cultures.	Oligodeoxyribonucleotides	16-36	cyclin dependent kinase 1	Homo sapiens	74-78
1731328-8	1992	In contrast, an oligodeoxynucleotide blocking production of the human 2Hs cdc2 homolog interfered with production of the human 2Hs cdc2 homolog interfered with cellular proliferation without altering the cell-type composition of these cultures.	Oligodeoxyribonucleotides	16-36	cyclin dependent kinase 1	Homo sapiens	131-135
1327370-6	1992	These results fit well with expected function of the proteins, associated solely in higher eucaryotes, to dephosphorylation of threonine in the cell cycle control protein cdc2.	Threonine	127-136	cyclin dependent kinase 1	Homo sapiens	171-175
1534688-8	1992	Inhibition was not due to decreased levels of cdc2 or cyclin B protein; rather, G2 arrest correlated with the accumulation of both tyrosine-phosphorylated cdc2 and cyclin B.	Tyrosine	131-139	cyclin dependent kinase 1	Homo sapiens	155-159
1944283-7	1991	Using an alanine scanning mutagenesis method, we analyzed the interaction between Cdc2 and Suc1.	Alanine	9-16	cyclin dependent kinase 1	Homo sapiens	82-86
1483348-3	1992	In in vivo phosphorylated Rb protein, we have found ten phosphotryptic peptides, all of which could be phosphorylated by cdc2 kinase, p34cdc2, in vitro.	Peptides	71-79	cyclin dependent kinase 1	Homo sapiens	134-141
1483352-3	1992	Avian p34cdc2 is phosphorylated on threonine 14 (Thr14), tyrosine 15 (Tyr15), threonine 161 (Thr161) and serine 277 (Ser277).	Threonine	35-44	cyclin dependent kinase 1	Homo sapiens	6-13
1483352-3	1992	Avian p34cdc2 is phosphorylated on threonine 14 (Thr14), tyrosine 15 (Tyr15), threonine 161 (Thr161) and serine 277 (Ser277).	Tyrosine	57-65	cyclin dependent kinase 1	Homo sapiens	6-13
1483352-3	1992	Avian p34cdc2 is phosphorylated on threonine 14 (Thr14), tyrosine 15 (Tyr15), threonine 161 (Thr161) and serine 277 (Ser277).	Threonine	78-87	cyclin dependent kinase 1	Homo sapiens	6-13
1483352-3	1992	Avian p34cdc2 is phosphorylated on threonine 14 (Thr14), tyrosine 15 (Tyr15), threonine 161 (Thr161) and serine 277 (Ser277).	Serine	105-111	cyclin dependent kinase 1	Homo sapiens	6-13
1944283-7	1991	Using an alanine scanning mutagenesis method, we analyzed the interaction between Cdc2 and Suc1.	suc1	91-95	cyclin dependent kinase 1	Homo sapiens	82-86
1933864-3	1991	In growing human and Syrian hamster fibroblasts, three 35S-labeled proteins of 34-36 kDa were immunoprecipitated with p34cdc2 antiserum.	Sulfur-35	55-58	cyclin dependent kinase 1	Homo sapiens	118-125
1961714-1	1991	The cdc25+ gene of fission yeast encodes a phosphotyrosine phosphatase that dephosphorylates tyrosine-15 of p34cdc2 and thereby activates p34cdc2/cyclin to bring about entry into M phase.	Tyrosine	50-58	cyclin dependent kinase 1	Homo sapiens	108-115
1961714-1	1991	The cdc25+ gene of fission yeast encodes a phosphotyrosine phosphatase that dephosphorylates tyrosine-15 of p34cdc2 and thereby activates p34cdc2/cyclin to bring about entry into M phase.	Tyrosine	50-58	cyclin dependent kinase 1	Homo sapiens	138-145
1933864-8	1991	In contrast to senescent and low serum-arrested cells, cdc2 mRNA was expressed at normal levels in cells partially growth arrested by isoleucine deficiency in G1, by aphidicolin at G1-S, by etoposide in G2, or by Colcemid in the M phase of the cell cycle, indicating that cdc2 down-regulation does not always occur upon growth arrest.	Aphidicolin	166-177	cyclin dependent kinase 1	Homo sapiens	55-59
1933864-8	1991	In contrast to senescent and low serum-arrested cells, cdc2 mRNA was expressed at normal levels in cells partially growth arrested by isoleucine deficiency in G1, by aphidicolin at G1-S, by etoposide in G2, or by Colcemid in the M phase of the cell cycle, indicating that cdc2 down-regulation does not always occur upon growth arrest.	Etoposide	190-199	cyclin dependent kinase 1	Homo sapiens	55-59
1655418-1	1991	In vertebrates, entry into mitosis is accompanied by dephosphorylation of p34cdc2 kinase on threonine 14 (Thr14) and tyrosine 15 (Tyr15).	Threonine	92-101	cyclin dependent kinase 1	Homo sapiens	74-81
1655274-1	1991	Genetic and biochemical studies have indicated that the cdc25 protein controls the entry into mitosis by triggering tyrosine dephosphorylation of the cdc2 protein kinase.	Tyrosine	116-124	cyclin dependent kinase 1	Homo sapiens	56-60
1833185-4	1991	The replacement of Thr161, a residue conserved and phosphorylated in other protein kinases, with valine inhibits cdc2 association with A and B cyclins.	Valine	97-103	cyclin dependent kinase 1	Homo sapiens	113-117
1833185-7	1991	These results suggest that a threonine phosphorylation/dephosphorylation cycle is involved in regulating cdc2 function.	Threonine	29-38	cyclin dependent kinase 1	Homo sapiens	105-109
1936263-4	1991	Its ability to phosphorylate casein but not histone, and its phosphorylation on tyrosine, detected by anti-phosphotyrosine antibodies, indicates the form of p34cdc2 purified is the inactive or apoenzyme form.	Tyrosine	80-88	cyclin dependent kinase 1	Homo sapiens	157-164
1936263-4	1991	Its ability to phosphorylate casein but not histone, and its phosphorylation on tyrosine, detected by anti-phosphotyrosine antibodies, indicates the form of p34cdc2 purified is the inactive or apoenzyme form.	Phosphotyrosine	107-122	cyclin dependent kinase 1	Homo sapiens	157-164
1918018-7	1991	All these experiments gave concordant results and demonstrate that at least at G0/G1, human fibroblasts contain a complex of active type II cAMP-dependent protein kinase associated through its RII alpha subunit with p34cdc2.	Cyclic AMP	140-144	cyclin dependent kinase 1	Homo sapiens	216-223
1751405-0	1991	Retinoic acid negatively regulates p34cdc2 expression during human neuroblastoma differentiation.	Tretinoin	0-13	cyclin dependent kinase 1	Homo sapiens	35-42
1751405-2	1991	In this work, we show that the arrest of cell growth and induction of differentiation in a tumorigenic neuroblastoma cell line by retinoic acid (RA) is associated with a 75-fold decrease in the level of p34cdc2 protein.	Tretinoin	130-143	cyclin dependent kinase 1	Homo sapiens	203-210
1751405-5	1991	These studies link regulation of cdc2 level, RB phosphorylation state, and induction of differentiation by RA and suggest that alterations in the cdc2 gene or in genes controlling its regulation contribute to tumorigenesis.	Rubidium	45-47	cyclin dependent kinase 1	Homo sapiens	146-150
1828290-1	1991	Oocytes arrested in the G2 phase of the cell cycle contain a p34cdc2/cyclin B complex which is kept in an inactive form by phosphorylation of its p34cdc2 subunit on tyrosine, threonine and perhaps serine residues.	Tyrosine	165-173	cyclin dependent kinase 1	Homo sapiens	61-68
1664235-2	1991	Recent studies have shown that p34cdc2 is also a major tyrosine-phosphorylated protein in HeLa cells and that its phosphotyrosine content is cell cycle regulated and related to its kinase activity.	Tyrosine	55-63	cyclin dependent kinase 1	Homo sapiens	31-38
1664235-2	1991	Recent studies have shown that p34cdc2 is also a major tyrosine-phosphorylated protein in HeLa cells and that its phosphotyrosine content is cell cycle regulated and related to its kinase activity.	Phosphotyrosine	114-129	cyclin dependent kinase 1	Homo sapiens	31-38
1664235-4	1991	Tyrosine phosphorylation of cdc2 in vitro occurs at tyrosine 15, the same site that is phosphorylated in vivo.	Tyrosine	0-8	cyclin dependent kinase 1	Homo sapiens	28-32
1664235-4	1991	Tyrosine phosphorylation of cdc2 in vitro occurs at tyrosine 15, the same site that is phosphorylated in vivo.	Tyrosine	52-60	cyclin dependent kinase 1	Homo sapiens	28-32
1828701-6	1991	These inhibitors prevented the 1-methyladenine-induced activations of the histone H1 kinase p34cdc2, the myelin basic protein kinase p44mpk and a ribosomal S6 peptide kinase.	1-methyladenine	31-46	cyclin dependent kinase 1	Homo sapiens	92-99
1828701-7	1991	Erbstatin, AG18 and AG125 prevented 1-methyladenine-induced tyrosine dephosphorylation of p34cdc2, and they inhibited tyrosine phosphorylation of p44mpk.	erbstatin	0-9	cyclin dependent kinase 1	Homo sapiens	90-97
1828701-7	1991	Erbstatin, AG18 and AG125 prevented 1-methyladenine-induced tyrosine dephosphorylation of p34cdc2, and they inhibited tyrosine phosphorylation of p44mpk.	tyrphostin A23	11-15	cyclin dependent kinase 1	Homo sapiens	90-97
1828701-7	1991	Erbstatin, AG18 and AG125 prevented 1-methyladenine-induced tyrosine dephosphorylation of p34cdc2, and they inhibited tyrosine phosphorylation of p44mpk.	AG125	20-25	cyclin dependent kinase 1	Homo sapiens	90-97
1828701-7	1991	Erbstatin, AG18 and AG125 prevented 1-methyladenine-induced tyrosine dephosphorylation of p34cdc2, and they inhibited tyrosine phosphorylation of p44mpk.	1-methyladenine	36-51	cyclin dependent kinase 1	Homo sapiens	90-97
1828701-7	1991	Erbstatin, AG18 and AG125 prevented 1-methyladenine-induced tyrosine dephosphorylation of p34cdc2, and they inhibited tyrosine phosphorylation of p44mpk.	Tyrosine	60-68	cyclin dependent kinase 1	Homo sapiens	90-97
1830667-8	1991	In hamster cells, the hyperphosphorylated form of p34cdc2 was complexed with cyclin B and underwent tyrosine dephosphorylation during caffeine-induced premature mitosis.	Tyrosine	100-108	cyclin dependent kinase 1	Homo sapiens	50-57
1830667-8	1991	In hamster cells, the hyperphosphorylated form of p34cdc2 was complexed with cyclin B and underwent tyrosine dephosphorylation during caffeine-induced premature mitosis.	Caffeine	134-142	cyclin dependent kinase 1	Homo sapiens	50-57
1828290-1	1991	Oocytes arrested in the G2 phase of the cell cycle contain a p34cdc2/cyclin B complex which is kept in an inactive form by phosphorylation of its p34cdc2 subunit on tyrosine, threonine and perhaps serine residues.	Tyrosine	165-173	cyclin dependent kinase 1	Homo sapiens	146-153
1828290-1	1991	Oocytes arrested in the G2 phase of the cell cycle contain a p34cdc2/cyclin B complex which is kept in an inactive form by phosphorylation of its p34cdc2 subunit on tyrosine, threonine and perhaps serine residues.	Threonine	175-184	cyclin dependent kinase 1	Homo sapiens	61-68
1828290-1	1991	Oocytes arrested in the G2 phase of the cell cycle contain a p34cdc2/cyclin B complex which is kept in an inactive form by phosphorylation of its p34cdc2 subunit on tyrosine, threonine and perhaps serine residues.	Serine	197-203	cyclin dependent kinase 1	Homo sapiens	61-68
1902553-0	1991	Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2.	Guanosine Triphosphate	29-32	cyclin dependent kinase 1	Homo sapiens	71-78
1850698-0	1991	Cyclin promotes the tyrosine phosphorylation of p34cdc2 in a wee1+ dependent manner.	Tyrosine	20-28	cyclin dependent kinase 1	Homo sapiens	48-55
1850698-3	1991	Co-production of p34cdc2 and p107wee1 in insect cells resulted in a minor population of p34cdc2 that was phosphorylated on tyrosine and displayed an altered electrophoretic mobility.	Tyrosine	123-131	cyclin dependent kinase 1	Homo sapiens	17-24
1850698-3	1991	Co-production of p34cdc2 and p107wee1 in insect cells resulted in a minor population of p34cdc2 that was phosphorylated on tyrosine and displayed an altered electrophoretic mobility.	Tyrosine	123-131	cyclin dependent kinase 1	Homo sapiens	88-95
1850698-4	1991	When p34cdc2 and p107wee1 were co-produced with cyclin (A or B) in insect cells, there was a dramatic increase in the population of p34cdc2 that was phosphorylated on tyrosine and that displayed a shift in electrophoretic mobility.	Tyrosine	167-175	cyclin dependent kinase 1	Homo sapiens	5-12
1850698-4	1991	When p34cdc2 and p107wee1 were co-produced with cyclin (A or B) in insect cells, there was a dramatic increase in the population of p34cdc2 that was phosphorylated on tyrosine and that displayed a shift in electrophoretic mobility.	Tyrosine	167-175	cyclin dependent kinase 1	Homo sapiens	132-139
1850698-5	1991	The phosphorylation of p34cdc2 on tyrosine was absolutely dependent upon the presence of kinase-active p107wee1.	Tyrosine	34-42	cyclin dependent kinase 1	Homo sapiens	23-30
1850698-7	1991	These results suggest that cyclin functions to facilitate tyrosine phosphorylation of p34cdc2 and that p107wee1 functions to regulate p34cdc2, either directly or indirectly, by tyrosine phosphorylation.	Tyrosine	58-66	cyclin dependent kinase 1	Homo sapiens	86-93
1850698-7	1991	These results suggest that cyclin functions to facilitate tyrosine phosphorylation of p34cdc2 and that p107wee1 functions to regulate p34cdc2, either directly or indirectly, by tyrosine phosphorylation.	Tyrosine	177-185	cyclin dependent kinase 1	Homo sapiens	134-141
2237430-4	1990	Antisense oligodeoxynucleotides could reduce the increase in cdc2 expression and inhibited DNA synthesis, but had no effect on several early and mid-G1 events, including blastogenesis and expression of interleukin-2 receptors, transferrin receptors, c-myb, and c-myc.	Oligodeoxyribonucleotides	10-31	cyclin dependent kinase 1	Homo sapiens	61-65
1849075-7	1991	The regulation of activity by dual phosphorylations at closely spaced threonyl and tyrosyl residues has a functional correlate in p34cdc2, and may be characteristic of a family of protein kinases regulating cell cycle transitions.	threonyl	70-78	cyclin dependent kinase 1	Homo sapiens	130-137
1849075-7	1991	The regulation of activity by dual phosphorylations at closely spaced threonyl and tyrosyl residues has a functional correlate in p34cdc2, and may be characteristic of a family of protein kinases regulating cell cycle transitions.	cyclo(tyrosyl-tyrosyl)	83-90	cyclin dependent kinase 1	Homo sapiens	130-137
2016282-2	1991	In this study we have demonstrated that smooth muscle caldesmon is phosphorylated in vitro by cdc2 kinase from mitotic phase HeLa cells to 1.2 mol of phosphate/mol of caldesmon.	Phosphates	150-159	cyclin dependent kinase 1	Homo sapiens	94-98
2013279-4	1991	Anticyclin immunoprecipitates, extracts purified on specific p34cdc2-binding p13suc1-Sepharose and affinity-purified H1 kinase display strong HMG I, Y and P1 phosphorylating activities, demonstrating that the p34cdc2/cyclincdc13 complex is the active kinase phosphorylating these HMG proteins.	Sepharose	85-94	cyclin dependent kinase 1	Homo sapiens	61-68
1668090-0	1991	Negative control of cdc2 kinase activation by cAMP in starfish oocytes.	Cyclic AMP	46-50	cyclin dependent kinase 1	Homo sapiens	20-24
2226469-6	1990	Phosphoamino acid analysis showed that the beta subunit was phosphorylated by cdc2 protein kinase at threonine residues while autophosphorylation involved serine residues.	Phosphoamino Acids	0-17	cyclin dependent kinase 1	Homo sapiens	78-82
2226469-6	1990	Phosphoamino acid analysis showed that the beta subunit was phosphorylated by cdc2 protein kinase at threonine residues while autophosphorylation involved serine residues.	Threonine	101-110	cyclin dependent kinase 1	Homo sapiens	78-82
2141171-3	1990	Serine-315 is phosphorylated by both p60-cdc2 and cyclin B-cdc2 enzymes.	Serine	0-6	cyclin dependent kinase 1	Homo sapiens	41-45
2118246-4	1990	In addition, cdc2 phosphorylated the v-fms polypeptides in serine and threonine residues.	Serine	59-65	cyclin dependent kinase 1	Homo sapiens	13-17
2118246-4	1990	In addition, cdc2 phosphorylated the v-fms polypeptides in serine and threonine residues.	Threonine	70-79	cyclin dependent kinase 1	Homo sapiens	13-17
2187601-0	1990	Inhibition of p34cdc2 kinase activity by etoposide or irradiation as a mechanism of G2 arrest in Chinese hamster ovary cells.	Etoposide	41-50	cyclin dependent kinase 1	Homo sapiens	14-21
2187601-7	1990	Treatment of either asynchronous CHO cells or an enriched G2 population with the antitumor agent, etoposide, results in rapid inhibition of immunoprecipitated p34cdc2 kinase activity, which is not due to a direct effect of drug upon the enzyme.	Etoposide	98-107	cyclin dependent kinase 1	Homo sapiens	159-166
2187601-8	1990	p34cdc2 kinase activity recovers as cells arrest in G2 and a second etoposide treatment further inhibits p34cdc2 kinase activity and prolongs G2 arrest.	Etoposide	68-77	cyclin dependent kinase 1	Homo sapiens	0-7
2187601-8	1990	p34cdc2 kinase activity recovers as cells arrest in G2 and a second etoposide treatment further inhibits p34cdc2 kinase activity and prolongs G2 arrest.	Etoposide	68-77	cyclin dependent kinase 1	Homo sapiens	105-112
2141171-3	1990	Serine-315 is phosphorylated by both p60-cdc2 and cyclin B-cdc2 enzymes.	Serine	0-6	cyclin dependent kinase 1	Homo sapiens	59-63
2155162-5	1990	The p34cdc2 subunit becomes tyrosine-dephosphorylated as the H1K is activated during entry of the oocytes into M phase, whereas the cyclin subunit is reciprocally phosphorylated.	Tyrosine	28-36	cyclin dependent kinase 1	Homo sapiens	4-11
2156209-4	1990	Serine 315 within this p53 structural motif is phosphorylated in vitro by the cell cycle kinase p34cdc2.	Serine	0-6	cyclin dependent kinase 1	Homo sapiens	96-103
2197066-4	1990	Phosphorylation on serine during late G1 is accompanied by a significant increase in p34cdc2 kinase activity which, by analogy with fission yeast, may betray a function related to control over entry into S phase.	Serine	19-25	cyclin dependent kinase 1	Homo sapiens	85-92
33971703-0	2022	Enrichment of Wee1/CDC2 and NF-kappaB Signaling Pathway Constituents Mutually Contributes to CDDP Resistance in Human Osteosarcoma.	Cisplatin	93-97	cyclin dependent kinase 1	Homo sapiens	19-23
33971703-2	2022	Although the Wee1/CDC2 and NF-kappaB pathways were reported to show abnormal activation in some tumor cells with CDDP resistance, whether there is any concrete connection is currently unclear.	Cisplatin	113-117	cyclin dependent kinase 1	Homo sapiens	18-22
33971703-8	2022	In the highly CDDP-tolerant cell lines, Wee1 and RelA were physically crosslinked, which resulted in increased abundance of phosphorylated CDC2 (Y15) and RelA (S536) and consequent modulation of cell cycle progression, survival and proliferation.	Cisplatin	14-18	cyclin dependent kinase 1	Homo sapiens	139-143
33971703-11	2022	Conclusion: Simultaneous enrichment of molecules in the Wee1/CDC2 and NF-kappaB pathways and their consequent coactivation is a new molecular mechanism of CDDP resistance in OS cells.	Cisplatin	155-159	cyclin dependent kinase 1	Homo sapiens	61-65
33797919-8	2021	Third, we found that the activation of CDK1 following 4-12 h of mTOR inhibition was accompanied by the activation of the Greatwall-endosulfine complex.	endosulfine	131-142	cyclin dependent kinase 1	Homo sapiens	39-43
33797919-10	2021	Our data implied that mTOR inhibition could contribute to CDK1 activation for further regulating cell cycle progression, which was mediated by the Greatwall-endosulfine complex.	greatwall	147-156	cyclin dependent kinase 1	Homo sapiens	58-62
33797919-10	2021	Our data implied that mTOR inhibition could contribute to CDK1 activation for further regulating cell cycle progression, which was mediated by the Greatwall-endosulfine complex.	endosulfine	157-168	cyclin dependent kinase 1	Homo sapiens	58-62
33821934-6	2021	In addition, DCZ0825 induced cell cycle arrest in the G2/M phase by downregulating Cdc25C, CDK1, and Cyclin B1, thus interfering with cell proliferation.	dcz0825	13-20	cyclin dependent kinase 1	Homo sapiens	91-95
33806566-5	2021	Furthermore, BA decreased the expression of cell cycle regulators, such as cyclin B1, cyclin A, cyclin-dependent kinase (Cdk) 2, cell division cycle (Cdc) 2, and Cdc25c.	betulinic acid	13-15	cyclin dependent kinase 1	Homo sapiens	129-156
33821368-11	2021	Ozone induced G2/M phase cell cycle arrest, which could be elucidated by the change of protein levels of p53, p21, Cyclin D1, cyclin B1, cdc2, and CDK4.	Ozone	0-5	cyclin dependent kinase 1	Homo sapiens	137-141
33799762-5	2021	Structural and functional studies have demonstrated that silencing or inhibition of ABCC6 with probenecid changed the expression of several genes and proteins such as NT5E and TNAP, as well as Lamin, and CDK1, which are involved in cell motility and cell cycle.	Probenecid	95-105	cyclin dependent kinase 1	Homo sapiens	204-208
28401191-2	2017	We recently demonstrated that proteasomal degradation of EZH2 resulting from cyclin-dependent kinase 1 (CDK1)-induced phosphorylation at Threonine (T) 487 represents a novel mechanism of drug resistance in acute myeloid leukemia (AML).	Threonine	137-146	cyclin dependent kinase 1	Homo sapiens	77-102
28401191-2	2017	We recently demonstrated that proteasomal degradation of EZH2 resulting from cyclin-dependent kinase 1 (CDK1)-induced phosphorylation at Threonine (T) 487 represents a novel mechanism of drug resistance in acute myeloid leukemia (AML).	Threonine	137-146	cyclin dependent kinase 1	Homo sapiens	104-108
34712357-3	2021	In the present study, it was found that delphinidin could induce G2/M phase cell cycle arrest by inhibiting the protein expression level of cyclin B1 and Cdk1 in HER-2-positive breast cancer cell lines.	delphinidin	40-51	cyclin dependent kinase 1	Homo sapiens	154-158
10588655-6	1999	This correlated with elevated Cdc2 tyrosine 15 phosphorylation, decreased Cdc2 activity, and decreased Cdc25C protein levels.	Tyrosine	35-43	cyclin dependent kinase 1	Homo sapiens	30-34
34856073-11	2022	Kaplan-Meier plotter analysis found that resveratrol-induced expression changes in key RNAs, such as E2F2, JUN, FOS, BRCA1, CDK1, CDKN1A, TNF and hsa-miR-34a-5p, significantly improved the prognosis of breast cancer patients, which was further verified using real-time quantitative PCR (qPCR) and western blotting.	Resveratrol	41-52	cyclin dependent kinase 1	Homo sapiens	124-128
34782203-9	2022	DHE treatment led to G2/M arrest via a reduction of cyclin B1/CDK1 and caspase-dependent apoptosis.	dehydroevodiamine	0-3	cyclin dependent kinase 1	Homo sapiens	62-66
34910930-5	2022	These phenotypes resulted from the action of food-derived retinoic acid (ATRA), which enhanced actomyosin contractility and promoted LP cDC2 transmigration into the epithelium.	Tretinoin	58-71	cyclin dependent kinase 1	Homo sapiens	136-140
34910930-5	2022	These phenotypes resulted from the action of food-derived retinoic acid (ATRA), which enhanced actomyosin contractility and promoted LP cDC2 transmigration into the epithelium.	Tretinoin	73-77	cyclin dependent kinase 1	Homo sapiens	136-140
34954029-5	2022	Olaparib induced the feedback overexpression of PARP1, FOXM1, CDC25A, CCND1, CDK1, CCNA2, CCNB1, CDC25B, BRCA1/2 and Rad51 to promote the acceleration of cell mitosis and recovery of DNA repair, which caused the generation of adaptive resistance.	olaparib	0-8	cyclin dependent kinase 1	Homo sapiens	77-81
34951372-9	2021	beta-Estradiol induces G2/M cell cycle arrest through downregulating Cyclin B1 and p-CDK1.	Estradiol	0-14	cyclin dependent kinase 1	Homo sapiens	85-89
34988084-5	2021	A total of 268 active components were identified from SQSBD, among which 9 key components (Quercetin, luteolin, kaempferol, licochalcone A, formononetin, wogonin, beta-sitosterol, oroxylin A, naringenin, and baicalein) were hit by the 6 hub targets (CDK1, MAPK1, JUN, PCNA, HSB1, STAT3) associated with leukemia.	baicalein	208-217	cyclin dependent kinase 1	Homo sapiens	250-254
34988084-6	2021	Molecular docking showed that two core active components, quercetin and licochalcone A, exhibited the highest component-like properties (DL), and could bind well to CDK1 and MAPK1 protein.	Quercetin	58-67	cyclin dependent kinase 1	Homo sapiens	165-169
34988084-6	2021	Molecular docking showed that two core active components, quercetin and licochalcone A, exhibited the highest component-like properties (DL), and could bind well to CDK1 and MAPK1 protein.	licochalcone A	72-86	cyclin dependent kinase 1	Homo sapiens	165-169
34988084-7	2021	The experimental validation of these two components showed that quercetin inhibited cell growth through CDK1 dephosphorylation-mediated cell cycle arrest at G2/M phase in human AML U937 and HL60 cells, and licochalcone A induced cell differentiation in these leukemia cells via activation of MAPK1 and upregulation of CD11b.	Quercetin	64-73	cyclin dependent kinase 1	Homo sapiens	104-108
34924499-0	2022	CircCDK1 knockdown reduces CDK1 expression by targeting miR-489-3p to suppress the development of breast cancer and strengthen the sensitivity of Tamoxifen.	mir-489-3p	56-66	cyclin dependent kinase 1	Homo sapiens	27-31
34924499-0	2022	CircCDK1 knockdown reduces CDK1 expression by targeting miR-489-3p to suppress the development of breast cancer and strengthen the sensitivity of Tamoxifen.	Tamoxifen	146-155	cyclin dependent kinase 1	Homo sapiens	27-31
34924499-18	2022	CircCDK1 knockdown enhanced the sensitivity of Tamoxifen in breast cancer cells and suppressed cell growth and survival by depleting CDK1 expression via releasing miR- 489-3p.	Tamoxifen	47-56	cyclin dependent kinase 1	Homo sapiens	133-137
34435521-10	2021	Furthermore, IL-33 negatively regulates cyclin B1 protein level while increasing the expression of CDK1, with SB203580 inhibiting the effect.	SB 203580	110-118	cyclin dependent kinase 1	Homo sapiens	99-103
34585634-11	2021	In summary, miR-195-3p improves the radiosensitivity of NPC cells by targeting and regulating CDK1.	mir-195-3p	12-22	cyclin dependent kinase 1	Homo sapiens	94-98
34678723-8	2021	In addition, the accumulation of reactive oxygen species dissociated the CCNB1/CDK1 complex and induced G2/M cell cycle arrest.	Reactive Oxygen Species	33-56	cyclin dependent kinase 1	Homo sapiens	79-83
34853300-0	2021	Counteraction between Astrin-PP1 and Cyclin-B-CDK1 pathways protects chromosome-microtubule attachments independent of biorientation.	astrin-pp1	22-32	cyclin dependent kinase 1	Homo sapiens	46-50
34820014-11	2022	Taken together, the results of the present study suggest that miR-337-3p plays a tumor-suppressive role in BC by targeting CDK1.	mir-337-3p	62-72	cyclin dependent kinase 1	Homo sapiens	123-127
34946628-4	2021	Janerin caused the cell cycle arrest at the G2/M phase by decreasing the CDK1/Cyclin-B complex.	Janerin	0-7	cyclin dependent kinase 1	Homo sapiens	73-77
34789301-9	2021	However, under the treatment of ghrelin, cisplatin treatment exhibited a stronger effect on inhibiting P21 expression, upregulating p-CDK1 and cyclin B1 expression, and blocking cell cycle progression.	Ghrelin	32-39	cyclin dependent kinase 1	Homo sapiens	134-138
34789301-11	2021	CONCLUSION: This study revealed a specifically inhibitory effect of ghrelin on platinum-resistance via suppressing p-P38 and subsequently promoting p-CDK1 mediated cell cycle arrest in HO-8910 PM.	Platinum	79-87	cyclin dependent kinase 1	Homo sapiens	150-154
34791727-4	2022	The kinase activity of CDK1 critically depends on the phosphorylation of a Threonine residue in its activation loop by a CDK1 activating kinase (CAK).	Threonine	75-84	cyclin dependent kinase 1	Homo sapiens	23-27
34831298-4	2021	The modified residue, alpha5-Ser16, is within a SP motif typically recognized by cyclin-dependent kinases (CDKs).	alpha5-ser16	22-34	cyclin dependent kinase 1	Homo sapiens	107-111
34831298-4	2021	The modified residue, alpha5-Ser16, is within a SP motif typically recognized by cyclin-dependent kinases (CDKs).	TFF2 protein, human	48-50	cyclin dependent kinase 1	Homo sapiens	107-111
34829859-12	2021	Both drugs modulated CDK-cyclin and AKT-dependent signaling, associated either with both HUVEC growth and angiogenesis (axitinib) or angiogenesis alone (sorafenib).	Axitinib	120-128	cyclin dependent kinase 1	Homo sapiens	21-24
34829859-12	2021	Both drugs modulated CDK-cyclin and AKT-dependent signaling, associated either with both HUVEC growth and angiogenesis (axitinib) or angiogenesis alone (sorafenib).	Sorafenib	153-162	cyclin dependent kinase 1	Homo sapiens	21-24
34796115-0	2021	Dihydroartemisinin Suppresses the Tumorigenesis and Cycle Progression of Colorectal Cancer by Targeting CDK1/CCNB1/PLK1 Signaling.	artenimol	0-18	cyclin dependent kinase 1	Homo sapiens	104-108
34796115-6	2021	Further analyses indicated that the targets of DHA were predominantly enriched in cell cycle-associated pathways, including CDK1, CCNB1, and PLK1; and DHA could bind with the CDK1/CCNB1 complex and inhibit the activation of CDK1/CCNB1/PLK1 signaling.	artenimol	47-50	cyclin dependent kinase 1	Homo sapiens	124-128
34796115-6	2021	Further analyses indicated that the targets of DHA were predominantly enriched in cell cycle-associated pathways, including CDK1, CCNB1, and PLK1; and DHA could bind with the CDK1/CCNB1 complex and inhibit the activation of CDK1/CCNB1/PLK1 signaling.	artenimol	47-50	cyclin dependent kinase 1	Homo sapiens	175-179
34796115-6	2021	Further analyses indicated that the targets of DHA were predominantly enriched in cell cycle-associated pathways, including CDK1, CCNB1, and PLK1; and DHA could bind with the CDK1/CCNB1 complex and inhibit the activation of CDK1/CCNB1/PLK1 signaling.	artenimol	47-50	cyclin dependent kinase 1	Homo sapiens	224-228
34796115-6	2021	Further analyses indicated that the targets of DHA were predominantly enriched in cell cycle-associated pathways, including CDK1, CCNB1, and PLK1; and DHA could bind with the CDK1/CCNB1 complex and inhibit the activation of CDK1/CCNB1/PLK1 signaling.	artenimol	151-154	cyclin dependent kinase 1	Homo sapiens	175-179
34796115-6	2021	Further analyses indicated that the targets of DHA were predominantly enriched in cell cycle-associated pathways, including CDK1, CCNB1, and PLK1; and DHA could bind with the CDK1/CCNB1 complex and inhibit the activation of CDK1/CCNB1/PLK1 signaling.	artenimol	151-154	cyclin dependent kinase 1	Homo sapiens	224-228
34796115-7	2021	Moreover, cucurbitacin E, a specific inhibitor of the CDK1/CCNB1 axis, enhanced the inhibitory effects of DHA on DNA synthesis and colony formation in HCT116 and DLD1 cells.	cucurbitacin E	10-24	cyclin dependent kinase 1	Homo sapiens	54-58
34796115-7	2021	Moreover, cucurbitacin E, a specific inhibitor of the CDK1/CCNB1 axis, enhanced the inhibitory effects of DHA on DNA synthesis and colony formation in HCT116 and DLD1 cells.	artenimol	106-109	cyclin dependent kinase 1	Homo sapiens	54-58
34796115-8	2021	In short, DHA could suppress the tumorigenesis and cycle progression of CRC cells by targeting CDK1/CCNB1/PLK1 signaling.	artenimol	10-13	cyclin dependent kinase 1	Homo sapiens	95-99
34555628-0	2021	Synthesis, in vitro anticancer activity and in silico studies of certain pyrazole-based derivatives as potential inhibitors of cyclin dependent kinases (CDKs).	pyrazole	73-81	cyclin dependent kinase 1	Homo sapiens	153-157
34555628-5	2021	Screening the synthesized compounds 8a-c for inhibition of CDK isoforms revealed that compound 8a exhibited nearly equal inhibition to all the tested CDK isoforms, while compound 8b inhibits CDK4/D1 preferentially than the other isoforms and compound 8c inhibits CDK1, CDK2 and CDK4 more than CDK7.	8a-c	36-40	cyclin dependent kinase 1	Homo sapiens	59-62
34555628-5	2021	Screening the synthesized compounds 8a-c for inhibition of CDK isoforms revealed that compound 8a exhibited nearly equal inhibition to all the tested CDK isoforms, while compound 8b inhibits CDK4/D1 preferentially than the other isoforms and compound 8c inhibits CDK1, CDK2 and CDK4 more than CDK7.	8a-c	36-40	cyclin dependent kinase 1	Homo sapiens	150-153
34673013-0	2021	Cyclin-dependent kinase 1 as a potential target for lycorine against hepatocellular carcinoma.	lycorine	52-60	cyclin dependent kinase 1	Homo sapiens	0-25
34673013-5	2021	Simultaneously, the anti-HCC effect of lycorine was comparable to that of interfering with these three genes, and lycorine significantly promoted the decrease both in protein and mRNA expression of CDK1.	lycorine	39-47	cyclin dependent kinase 1	Homo sapiens	198-202
34673013-5	2021	Simultaneously, the anti-HCC effect of lycorine was comparable to that of interfering with these three genes, and lycorine significantly promoted the decrease both in protein and mRNA expression of CDK1.	lycorine	114-122	cyclin dependent kinase 1	Homo sapiens	198-202
34673013-6	2021	Molecular validation mechanistically demonstrated that lycorine might attenuate the degradation rate of CDK1 via interaction with it, which had been confirmed by cellular thermal shift assay and drug affinity responsive targets stability assay.	lycorine	55-63	cyclin dependent kinase 1	Homo sapiens	104-108
34673013-7	2021	Taken together, these findings suggested that CDK1, CCNB1 and CCNB2 could be regarded as potential diagnostic and prognostic biomarkers for HCC, and CDK1 might serve as a promising therapeutic target for lycorine against HCC.	lycorine	204-212	cyclin dependent kinase 1	Homo sapiens	46-50
34673013-7	2021	Taken together, these findings suggested that CDK1, CCNB1 and CCNB2 could be regarded as potential diagnostic and prognostic biomarkers for HCC, and CDK1 might serve as a promising therapeutic target for lycorine against HCC.	lycorine	204-212	cyclin dependent kinase 1	Homo sapiens	149-153
34606419-0	2021	Cdc25C/cdc2/cyclin B, raf/MEK/ERK and PERK/eIF2alpha/CHOP pathways are involved in forskolin-induced growth inhibition of MM.1S cells by G2/M arrest and mitochondrion-dependent apoptosis.	Colforsin	83-92	cyclin dependent kinase 1	Homo sapiens	7-11
34606419-5	2021	Furthermore, we demonstrated that forskolin induced G2/M phase arrest with a remarkable increase of p-cdc25c, p-cdc2, and a decrease of cyclin B1, indicating the suppression of cdc25C/cdc2/cyclin B pathway.	Colforsin	34-43	cyclin dependent kinase 1	Homo sapiens	112-116
34606419-5	2021	Furthermore, we demonstrated that forskolin induced G2/M phase arrest with a remarkable increase of p-cdc25c, p-cdc2, and a decrease of cyclin B1, indicating the suppression of cdc25C/cdc2/cyclin B pathway.	Colforsin	34-43	cyclin dependent kinase 1	Homo sapiens	184-188
34949331-8	2021	Western blot showed that the levels of cyclin-dependent kinase 1(CDK1), cyclinB1 and cyclinB2 in P10, P20 and P30 cells after exposure were lower than those in DMSO control group during the same period, which was consistent with the microarray results.	Dimethyl Sulfoxide	160-164	cyclin dependent kinase 1	Homo sapiens	39-64
34949331-8	2021	Western blot showed that the levels of cyclin-dependent kinase 1(CDK1), cyclinB1 and cyclinB2 in P10, P20 and P30 cells after exposure were lower than those in DMSO control group during the same period, which was consistent with the microarray results.	Dimethyl Sulfoxide	160-164	cyclin dependent kinase 1	Homo sapiens	65-69
34789301-9	2021	However, under the treatment of ghrelin, cisplatin treatment exhibited a stronger effect on inhibiting P21 expression, upregulating p-CDK1 and cyclin B1 expression, and blocking cell cycle progression.	Cisplatin	41-50	cyclin dependent kinase 1	Homo sapiens	134-138
34789301-10	2021	Mechanistically, ghrelin promoted S phase cell cycle arrest and upregulated p-CDK1 and cyclin B1 expression induced by cisplatin via inhibition of p38.	Ghrelin	17-24	cyclin dependent kinase 1	Homo sapiens	78-82
34789301-10	2021	Mechanistically, ghrelin promoted S phase cell cycle arrest and upregulated p-CDK1 and cyclin B1 expression induced by cisplatin via inhibition of p38.	Cisplatin	119-128	cyclin dependent kinase 1	Homo sapiens	78-82
34789301-11	2021	CONCLUSION: This study revealed a specifically inhibitory effect of ghrelin on platinum-resistance via suppressing p-P38 and subsequently promoting p-CDK1 mediated cell cycle arrest in HO-8910 PM.	Ghrelin	68-75	cyclin dependent kinase 1	Homo sapiens	150-154
34612529-8	2021	Cell cycle and western blotting analysis revealed that 9-ethynyl noscapine treatment resulted in cell cycle arrest at G2/M and decreased CDK1 and cyclinB1 protein expression.	9-ethynyl noscapine	55-74	cyclin dependent kinase 1	Homo sapiens	137-141
34745968-11	2021	Additionally, in vitro experiments showed that PL inhibited proliferation and induced apoptosis via targeting CDK1 in EOC SKOV3 cells.	piperlonguminine	47-49	cyclin dependent kinase 1	Homo sapiens	110-114
34126457-11	2021	Through western blotting analysis, the beta-tubulin and cyclin B1 expression in the Tn-Lipo-PTX group were significantly higher compared with other groups and the CDK1 was down-regulated compared with PTX group, which indicated that targeting liposome delivery system could not only change periodic proteins expression, but also improve the killing effect of PTX on hepatocarcinoma cell.	Paclitaxel	359-362	cyclin dependent kinase 1	Homo sapiens	163-167
34233076-0	2021	Design, synthesis and primary activity assays of baicalein derivatives as cyclin-dependent kinase1 inhibitors.	baicalein	49-58	cyclin dependent kinase 1	Homo sapiens	74-98
34233076-4	2021	Here in, we reported a series of baicalein derivatives, which remarkably repressed the proliferation of MCF-7 tumor cells and the activity of CDK1/cyclin B kinase.	baicalein derivatives	33-54	cyclin dependent kinase 1	Homo sapiens	142-146
34233076-8	2021	Molecular docking results suggested that compound 3o can interact with the key amino acid residues, E81, L83 and D146, of CDK1 through hydrogen bond just like flavopiridol does.	Hydrogen	135-143	cyclin dependent kinase 1	Homo sapiens	122-126
34233076-8	2021	Molecular docking results suggested that compound 3o can interact with the key amino acid residues, E81, L83 and D146, of CDK1 through hydrogen bond just like flavopiridol does.	alvocidib	159-171	cyclin dependent kinase 1	Homo sapiens	122-126
34233076-10	2021	These findings proved that baicalein derivatives can be used as CDK1 inhibitors fighting against cancer.	baicalein	27-36	cyclin dependent kinase 1	Homo sapiens	64-68
34703821-5	2021	During the differentiation process that induced manifestation of breast cancer stem-like cells, DS significantly inhibited mammosphere formation in a dose-dependent manner and increased the expression of p53 and p21 in breast cancer stem-like cells, reducing the expression of cdc2 and cyclin B1 in MDA-MB-231 cells and cyclin D, cyclin E, CDK4, and CDK2 in MCF-7 cells.	dioscin	96-98	cyclin dependent kinase 1	Homo sapiens	277-281
34669117-10	2021	In addition, genistein upregulated Phospho-cdc2, Myt1, Cyclin A, Cyclin E2, p21 and Phospho-histone H3, but downregulated Phospho-wee1.	Genistein	13-22	cyclin dependent kinase 1	Homo sapiens	43-47
34435645-0	2021	Proteasome inhibitors decrease paclitaxel-induced cell death in nasopharyngeal carcinoma with the accumulation of CDK1/cyclin B1.	Paclitaxel	31-41	cyclin dependent kinase 1	Homo sapiens	114-118
34435645-7	2021	In addition, proteasome inhibitors combined with paclitaxel led to decreased MCL1 apoptosis regulator, BCL2 family member/Caspase-9/poly (ADP-ribose) polymerase apoptosis signaling triggered by CDK1/cyclin B1.	Paclitaxel	49-59	cyclin dependent kinase 1	Homo sapiens	194-198
34435645-8	2021	Therefore, dysfunction of CDK1/cyclin B1 could be defining the loss of paclitaxel lethality against cancer cells, a phenomenon affirmed by the CDK1 inhibitor Ro3306.	Paclitaxel	71-81	cyclin dependent kinase 1	Homo sapiens	26-30
34435645-8	2021	Therefore, dysfunction of CDK1/cyclin B1 could be defining the loss of paclitaxel lethality against cancer cells, a phenomenon affirmed by the CDK1 inhibitor Ro3306.	Paclitaxel	71-81	cyclin dependent kinase 1	Homo sapiens	143-147
34435645-8	2021	Therefore, dysfunction of CDK1/cyclin B1 could be defining the loss of paclitaxel lethality against cancer cells, a phenomenon affirmed by the CDK1 inhibitor Ro3306.	RO 3306	158-164	cyclin dependent kinase 1	Homo sapiens	26-30
34435645-8	2021	Therefore, dysfunction of CDK1/cyclin B1 could be defining the loss of paclitaxel lethality against cancer cells, a phenomenon affirmed by the CDK1 inhibitor Ro3306.	RO 3306	158-164	cyclin dependent kinase 1	Homo sapiens	143-147
34435645-9	2021	Overall, the present results demonstrated that a combination of paclitaxel with proteasome inhibitors or CDK1 inhibitors is antagonistic to effective clinical management of NPC.	Paclitaxel	64-74	cyclin dependent kinase 1	Homo sapiens	105-109
34611473-3	2021	To further investigate the molecular mechanism of HIF-1alpha destabilization by CDK1 or CDK4/6 inhibitors, we performed a proteomic screen on immunoprecipitated HIF-1alpha from hypoxic colorectal cancer cells that were either untreated or treated with CDK1 inhibitor Ro3306 and CDK4/6 inhibitor palbociclib.	RO 3306	267-273	cyclin dependent kinase 1	Homo sapiens	252-256
34530507-8	2021	In addition, mRNA expressions of CyclinA (P =0.0109), CyclinB (P =0.0019), CyclinD (P =0.0015), CDK1(P =0.0001), E2F1(P =0.0323), E2F4 (P =0.0101) and E2F5 (P =0.0018) were lower in RG1 and RG2.	rg2	190-193	cyclin dependent kinase 1	Homo sapiens	96-100
34534577-9	2022	Dinaciclib did not affect MEK signaling but decreased the expression of several prosurvival proteins, including survivin and CDK1, to induce apoptosis and inhibit mitosis.	dinaciclib	0-10	cyclin dependent kinase 1	Homo sapiens	125-129
34500757-2	2021	In this study, twelve in-house indole-based derivatives were preliminary evaluated for their inhibitory activities over VEGFR-2, CDK-1/cyclin B and HER-2.	indole	31-37	cyclin dependent kinase 1	Homo sapiens	129-134
34595111-0	2021	Identification of the Effects of Chondroitin Sulfate on Inhibiting CDKs in Colorectal Cancer Based on Bioinformatic Analysis and Experimental Validation.	Chondroitin Sulfates	33-52	cyclin dependent kinase 1	Homo sapiens	67-71
34595111-8	2021	CS inhibited the gene and protein expression levels of CDKs and increased the ratios of apoptotic or dead HCT-116 cells by regulating mitogen-activated protein (MAP) kinase pathways.	Chondroitin Sulfates	0-2	cyclin dependent kinase 1	Homo sapiens	55-59
34500757-10	2021	In vitro and in silico studies demonstrate the indole-based derivative 15l as a selective dual CDK-1 and HER-2 inhibitor.	indole	47-53	cyclin dependent kinase 1	Homo sapiens	95-100
34413303-7	2021	By contrast, CD200+ mature cDC2 strongly induce Th2, but not Th17, differentiation.	th2	48-51	cyclin dependent kinase 1	Homo sapiens	27-31
34386075-0	2021	Anti-malarial drug dihydroartemisinin downregulates the expression levels of CDK1 and CCNB1 in liver cancer.	artenimol	19-37	cyclin dependent kinase 1	Homo sapiens	77-81
34386075-16	2021	In the present study, it was further demonstrated that DHA reduced the expression levels of CDK1 and CCNB1 in liver cancer.	artenimol	55-58	cyclin dependent kinase 1	Homo sapiens	92-96
34386075-17	2021	Overall, CDK1 and CCNB1 were the potential therapeutic targets of liver cancer, and DHA reduced the expression levels of CDK1 and CCNB1, and inhibited the proliferation of liver cancer cells.	artenimol	84-87	cyclin dependent kinase 1	Homo sapiens	9-13
34386075-17	2021	Overall, CDK1 and CCNB1 were the potential therapeutic targets of liver cancer, and DHA reduced the expression levels of CDK1 and CCNB1, and inhibited the proliferation of liver cancer cells.	artenimol	84-87	cyclin dependent kinase 1	Homo sapiens	121-125
34503199-5	2021	Targeting CDK1 showed promising results for PDAC treatment in different preclinical models, where CDK1 inhibition induced cell cycle arrest in the G2/M phase and led to induction of apoptosis.	pdac	44-48	cyclin dependent kinase 1	Homo sapiens	10-14
34503199-5	2021	Targeting CDK1 showed promising results for PDAC treatment in different preclinical models, where CDK1 inhibition induced cell cycle arrest in the G2/M phase and led to induction of apoptosis.	pdac	44-48	cyclin dependent kinase 1	Homo sapiens	98-102
34497808-8	2021	OXA also inhibited homologous recombination by CDK1 activity and importantly made cancers with normal BRCA1 function sensitive to PARP inhibition.	Oxaliplatin	0-3	cyclin dependent kinase 1	Homo sapiens	47-51
34072728-11	2021	Interestingly, NSC777201 demonstrated anti-proliferative and cytotoxic activities (GI50 = 1.6 microM~1.82 microM and TGI50 = 3.5 microM~3.63 microM) against the NCI panels of ovarian cancer cell lines and exhibited a robust interaction with stronger affinities for TTK, NEK2, and CDK1, than do the standard drug, paclitaxel.	Paclitaxel	313-323	cyclin dependent kinase 1	Homo sapiens	280-284
34352995-10	2022	We observed that AZD1775 downregulated p-CDK1, a G2/M cell cycle checkpoint protein, and induced early mitotic entry.	adavosertib	17-24	cyclin dependent kinase 1	Homo sapiens	41-45
34277407-1	2021	Cyclin-dependent kinase 10 (CDK10) is a CDC2-related serine/threonine kinase involved in cellular processes including cell proliferation, transcription regulation and cell cycle regulation.	Serine	53-59	cyclin dependent kinase 1	Homo sapiens	40-44
34181793-6	2021	Cell cycle arrest at G2 /M phase caused by surfactin was demonstrated through p53 and p21 accumulation combined p34cdc2 , phosphorylated p34cdc2 and cyclin B1 inhibition, which was regulated by NADPH oxidase-derived ROS.	surfactin peptide	43-52	cyclin dependent kinase 1	Homo sapiens	112-119
34181793-6	2021	Cell cycle arrest at G2 /M phase caused by surfactin was demonstrated through p53 and p21 accumulation combined p34cdc2 , phosphorylated p34cdc2 and cyclin B1 inhibition, which was regulated by NADPH oxidase-derived ROS.	surfactin peptide	43-52	cyclin dependent kinase 1	Homo sapiens	137-144
34181793-6	2021	Cell cycle arrest at G2 /M phase caused by surfactin was demonstrated through p53 and p21 accumulation combined p34cdc2 , phosphorylated p34cdc2 and cyclin B1 inhibition, which was regulated by NADPH oxidase-derived ROS.	Reactive Oxygen Species	216-219	cyclin dependent kinase 1	Homo sapiens	112-119
34181793-6	2021	Cell cycle arrest at G2 /M phase caused by surfactin was demonstrated through p53 and p21 accumulation combined p34cdc2 , phosphorylated p34cdc2 and cyclin B1 inhibition, which was regulated by NADPH oxidase-derived ROS.	Reactive Oxygen Species	216-219	cyclin dependent kinase 1	Homo sapiens	137-144
34249701-13	2021	Finally, gliclazide was shown to induce cell cycle arrest and apoptosis in LUAD cells possibly by targeting CCNB1, CCNB2, CDK1 and AURKA.	Gliclazide	9-19	cyclin dependent kinase 1	Homo sapiens	122-126
34177915-7	2021	Pre-exposure of cDC2 or CD14+ DCs to the live virus resulted in an increased production of IFN-alpha upon poly I:C stimulation, while pre-exposure to UV-inactivated virus tended to enhance the release of IL-10 upon gardiquimod stimulation.	Poly I-C	106-114	cyclin dependent kinase 1	Homo sapiens	16-20
34072728-9	2021	In addition to the PPI network, ingenuity pathway analysis also implicate TTK, NEK2, and CDK1 in the elevated salvage pyrimidine and pyridoxal pathways in ovarian cancer.	pyrimidine	118-128	cyclin dependent kinase 1	Homo sapiens	89-93
34072728-9	2021	In addition to the PPI network, ingenuity pathway analysis also implicate TTK, NEK2, and CDK1 in the elevated salvage pyrimidine and pyridoxal pathways in ovarian cancer.	Pyridoxal	133-142	cyclin dependent kinase 1	Homo sapiens	89-93
34149899-6	2021	Compared with the PBS control group, the A549, A549/DDP and A549/Taxol cells treated with NaI131, GA or a combination of the drugs exhibited G2/M arrest and increased percentages of total apoptotic cells, as well as significantly decreased protein levels of CDK1, cyclin B, mtp53, HSP90, Bcl-2 and P-gp, increased protein levels of Bax and decreased mRNA levels of p53 and HSP90.	pbs	18-21	cyclin dependent kinase 1	Homo sapiens	258-262
34149899-6	2021	Compared with the PBS control group, the A549, A549/DDP and A549/Taxol cells treated with NaI131, GA or a combination of the drugs exhibited G2/M arrest and increased percentages of total apoptotic cells, as well as significantly decreased protein levels of CDK1, cyclin B, mtp53, HSP90, Bcl-2 and P-gp, increased protein levels of Bax and decreased mRNA levels of p53 and HSP90.	nai131	90-96	cyclin dependent kinase 1	Homo sapiens	258-262
34149899-6	2021	Compared with the PBS control group, the A549, A549/DDP and A549/Taxol cells treated with NaI131, GA or a combination of the drugs exhibited G2/M arrest and increased percentages of total apoptotic cells, as well as significantly decreased protein levels of CDK1, cyclin B, mtp53, HSP90, Bcl-2 and P-gp, increased protein levels of Bax and decreased mRNA levels of p53 and HSP90.	gambogic acid	98-100	cyclin dependent kinase 1	Homo sapiens	258-262
34361688-11	2021	Meanwhile, neratinib downregulated HER, MEK1, ERK, c-Myc, CyclinB1, CyclinD and CDK1.	neratinib	11-20	cyclin dependent kinase 1	Homo sapiens	80-84
34361688-14	2021	On the other hand, siRNA-HER2 combination with neratinib increased HER2, MEK1, ERK, c-Myc, CyclinB1, CyclinD and CDK1 to normal levels.	neratinib	47-56	cyclin dependent kinase 1	Homo sapiens	113-117
34336656-7	2021	PCB downregulated the expression levels of proteins involved in cell cycle progression and apoptosis, including cyclinB1, Cdc2, PARP1, Bcl-2, and survivin, and upregulated protein levels of cleaved PARP1, cleaved caspase3, cleaved caspase9, and BAX.	pinocembrin	0-3	cyclin dependent kinase 1	Homo sapiens	122-126
34307447-13	2021	GSEA analyses revealed that cell cycle, DNA replication, and mismatch repair were associated with CDK1 expression, while spliceosome, RNA degradation and cell cycle were correlated with CDC20 expression.	gsea	0-4	cyclin dependent kinase 1	Homo sapiens	98-102
34073071-7	2021	Panobinostat induced the G2/M cell cycle arrest in SNU484 and SNU638 cells and subsequently decreased the G2/M phase regulatory-associated protein expression of p-Wee1, Myt1, and Cdc2.	Panobinostat	0-12	cyclin dependent kinase 1	Homo sapiens	179-183
34064109-4	2021	Inhibition of apigenin-induced reactive oxygen species (ROS) generation by a ROS scavenger N-acetyl-L-cysteine blocked the lipid raft membrane localization and activation of ASM and formation of ceramide-enriched lipid raft membranes, returned PI3K-Akt-GTP-Rac1-modulated CDK1-cyclin B1 activity, and subsequently restored the BCL-2/BCL-xL-regulated ER-mitochondrial bioenergetic activity.	Apigenin	14-22	cyclin dependent kinase 1	Homo sapiens	272-276
34067359-6	2021	CDK1 selective inhibitor CGP74514A (CGP) and the pan-CDK inhibitor flavopiridol (FLA) arrested OCI-AML3 cells in the G2/M phase, and induced cell apoptosis.	N(2)-(2-aminocyclohexyl)-N(6)-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine	25-34	cyclin dependent kinase 1	Homo sapiens	0-4
34067359-6	2021	CDK1 selective inhibitor CGP74514A (CGP) and the pan-CDK inhibitor flavopiridol (FLA) arrested OCI-AML3 cells in the G2/M phase, and induced cell apoptosis.	alvocidib	67-79	cyclin dependent kinase 1	Homo sapiens	53-56
34067359-6	2021	CDK1 selective inhibitor CGP74514A (CGP) and the pan-CDK inhibitor flavopiridol (FLA) arrested OCI-AML3 cells in the G2/M phase, and induced cell apoptosis.	alvocidib	81-84	cyclin dependent kinase 1	Homo sapiens	53-56
34064109-4	2021	Inhibition of apigenin-induced reactive oxygen species (ROS) generation by a ROS scavenger N-acetyl-L-cysteine blocked the lipid raft membrane localization and activation of ASM and formation of ceramide-enriched lipid raft membranes, returned PI3K-Akt-GTP-Rac1-modulated CDK1-cyclin B1 activity, and subsequently restored the BCL-2/BCL-xL-regulated ER-mitochondrial bioenergetic activity.	Reactive Oxygen Species	56-59	cyclin dependent kinase 1	Homo sapiens	272-276
34064109-4	2021	Inhibition of apigenin-induced reactive oxygen species (ROS) generation by a ROS scavenger N-acetyl-L-cysteine blocked the lipid raft membrane localization and activation of ASM and formation of ceramide-enriched lipid raft membranes, returned PI3K-Akt-GTP-Rac1-modulated CDK1-cyclin B1 activity, and subsequently restored the BCL-2/BCL-xL-regulated ER-mitochondrial bioenergetic activity.	Acetylcysteine	91-110	cyclin dependent kinase 1	Homo sapiens	272-276
34134960-6	2021	The results of Western blotting showed that curcumin also concentration-dependently increased the cellular expressions of caspase-3, caspase-9 and Bax and lowered the expressions of Bcl-2, cyclin B1, CDK1 and beta-catenin along with the downstream proteins cyclin D1 and c-myc in the Wnt/beta-catenin signaling pathway (P < 0.05).	Curcumin	44-52	cyclin dependent kinase 1	Homo sapiens	200-204
34386269-7	2021	In addition, GA arrested cell cycle at the S or G2 phase via p53-p21-Cdc2-cyclin B pathway in the same cells.	Gallic Acid	13-15	cyclin dependent kinase 1	Homo sapiens	69-73
35568265-3	2022	Our results reveal that imipramine inhibits the expression of several cell cycle- and DNA repair-associated proteins including E2F1, CDK1, Cyclin D1, and RAD51.	Imipramine	24-34	cyclin dependent kinase 1	Homo sapiens	133-137
34267439-0	2021	Relation between Vitamin D Level and Cyclin-Dependent Kinase-1 Gene Expression in Egyptian Patients with Lupus Nephritis and their Impact on Disease Activity.	Vitamin D	17-26	cyclin dependent kinase 1	Homo sapiens	37-62
34267439-3	2021	The aim of this study was to determine the relation between vitamin D level and CDK-1 in lupus nephritis patients and their impact on disease activity.	Vitamin D	60-69	cyclin dependent kinase 1	Homo sapiens	80-85
34267439-7	2021	There was a non-significant inverse correlation between vitamin D and CDK-1 (before RO-3306 addition) and a positive correlation after RO-3306.	Vitamin D	56-65	cyclin dependent kinase 1	Homo sapiens	70-75
34267439-7	2021	There was a non-significant inverse correlation between vitamin D and CDK-1 (before RO-3306 addition) and a positive correlation after RO-3306.	RO 3306	84-91	cyclin dependent kinase 1	Homo sapiens	70-75
34267439-8	2021	A significant positive correlation was found between CDK-1 gene expressions with urinary albumin/creatinine ratio.	Creatinine	97-107	cyclin dependent kinase 1	Homo sapiens	53-58
34267439-9	2021	However, a significant positive correlation was found between CDK-1 (after RO-3306 addition) and proteinuria.	RO 3306	75-82	cyclin dependent kinase 1	Homo sapiens	62-67
34267439-11	2021	There was a positive correlation between CDK-1 gene expression and CRP before and after RO-3306 addition.	RO 3306	88-95	cyclin dependent kinase 1	Homo sapiens	41-46
35628146-7	2022	BPA exposure has a considerable impact on 10 genes: ANAPC2, AURKA, CDK1, CCNA2, CCNB1, PLK1, BUB1, KIF22, PDE3B, and CCNB3, which are also associated with progesterone-mediated oocyte maturation pathways.	bisphenol A	0-3	cyclin dependent kinase 1	Homo sapiens	67-71
35203042-0	2022	Triptolide inhibits cell growth and inflammatory response of fibroblast-like synoviocytes by modulating hsa-circ-0003353/microRNA-31-5p/CDK1 axis in rheumatoid arthritis.	triptolide	0-10	cyclin dependent kinase 1	Homo sapiens	136-140
35367281-0	2022	The CDK1 inhibitor, Ro-3306, is a potential antiviral candidate against influenza virus infection.	RO 3306	20-27	cyclin dependent kinase 1	Homo sapiens	4-8
35367281-4	2022	We conducted this study to investigate the potential of the CDK1 inhibitor Ro-3306 in preventing influenza virus infection and to elucidate the underlying mechanism.	RO 3306	75-82	cyclin dependent kinase 1	Homo sapiens	60-64
35367281-5	2022	We showed that Ro-3306, a CDK1 inhibitor, exerts anti-influenza activity both in vitro and in vivo.	RO 3306	15-22	cyclin dependent kinase 1	Homo sapiens	26-30
35086956-9	2022	Further impairing DNA repair through CDK1 inhibition enhances DNA damage, induces cell death, and sensitizes OlapR cells to olaparib treatment.	olaparib	124-132	cyclin dependent kinase 1	Homo sapiens	37-41
35417031-4	2022	Dinaciclib, a CDK1/2/5/9 inhibitor, is currently being evaluated in clinical trials against various cancer types, including BC.	dinaciclib	0-10	cyclin dependent kinase 1	Homo sapiens	14-24
35631350-9	2022	Furthermore, HMN-214 induces apoptosis and significantly obstructs the cell cycle at the G2/M phase in NB cells by inhibiting multiple cell-cycle-related genes, such as PLK1, WEE1, CDK1, CDK2, Cyclin B1, CHK1, and CHK2.	(E)-4-(2-(2-(N-acetyl-N-(4-methoxybenzenesulfonyl)amino)stilbazole)) 1-oxide	13-20	cyclin dependent kinase 1	Homo sapiens	181-185
35631350-10	2022	HMN-214 significantly inhibits cell cycle regulator CDK1 and the phosphorylation and activation of PLK1 in NB.	(E)-4-(2-(2-(N-acetyl-N-(4-methoxybenzenesulfonyl)amino)stilbazole)) 1-oxide	0-7	cyclin dependent kinase 1	Homo sapiens	52-56
35443178-5	2022	Unexpectedly, we find that the commonly used CDK1 inhibitor RO3306 interferes with replication to preclude detection of G2 DNA synthesis, leading to the impression of a mitosis-driven response.	RO 3306	60-66	cyclin dependent kinase 1	Homo sapiens	45-49
35520289-8	2022	The network pharmacology analysis identified seven core targets (namely, AURKA, CDK1, CCNB1, CCNB2, CCNE1, CCNE2, and TTK) of curcumol in patients with COVID-19 and LUAD.	curcumol	126-134	cyclin dependent kinase 1	Homo sapiens	80-84
35440621-4	2022	Phosphorylation of serine-5 by CDK1 prevented the association of ID2 with core APC, impaired ubiquitylation and stabilized ID2 protein at the mitosis-G1 transition leading to inhibition of basic Helix-Loop-Helix (bHLH)-mediated transcription.	Serine	19-25	cyclin dependent kinase 1	Homo sapiens	31-35
35393397-4	2022	Furthermore, a series of experiments (luciferase reporter assay, RNA pull-down assay, and western blotting) showed that lncRNA-Gm3932 down-regulated Prc1 and Nuf2 by competitively sponging miR-344d-3-5p, which subsequently reduced the expression of cell cycle-related proteins CDK2, CDC2, and Cyclin B1, and increased the expression of P21 and P27.	gm3932	127-133	cyclin dependent kinase 1	Homo sapiens	283-287
35450041-6	2022	Indeed, after CI treatment, the protein level of CDK1 and Bcl-2/Bax decreased, indicating that CI induced the cell cycle of MDA-MB-231 arrest in the G2/M phase and increased the rate of apoptosis.	morin	14-16	cyclin dependent kinase 1	Homo sapiens	49-53
35450041-6	2022	Indeed, after CI treatment, the protein level of CDK1 and Bcl-2/Bax decreased, indicating that CI induced the cell cycle of MDA-MB-231 arrest in the G2/M phase and increased the rate of apoptosis.	morin	95-97	cyclin dependent kinase 1	Homo sapiens	49-53
35190352-9	2022	Moreover, lecanoric acid arrested the cell cycle, presumably in the M phase, since expression of cyclin B1 and phosphorylated histone H3 was upregulated, whereas the inactive cyclin-dependent kinase 1 (CDK1) was reduced in HCT-116 cells.	lecanoric acid	10-24	cyclin dependent kinase 1	Homo sapiens	175-200
35444283-5	2022	RP-6306 treatment causes unscheduled activation of CDK1 selectively in CCNE1-overexpressing cells, promoting early mitosis in cells undergoing DNA synthesis.	RP-6306	0-7	cyclin dependent kinase 1	Homo sapiens	51-55
34995734-14	2022	Besides, protein-protein interaction (PPI) analysis demonstrated that a network consisted of FOXM1, CCNA2, CCNB1, MYBL2, PLK1 and CDK1 might be response for DATS-induced G2/M cell cycle arrest and increased intracellular ROS.	ros	221-224	cyclin dependent kinase 1	Homo sapiens	130-134
35505963-7	2022	Furthermore, we demonstrated that miR-6077 protects LUAD cells from cell death induced by CDDP/PEM via CDKN1A-CDK1-mediated cell-cycle arrest and KEAP1-NRF2-SLC7A11/NQO1-mediated ferroptosis, thus resulting in chemoresistance in multiple LUAD cells both in vitro and in vivo.	Cisplatin	90-94	cyclin dependent kinase 1	Homo sapiens	110-114
35505963-7	2022	Furthermore, we demonstrated that miR-6077 protects LUAD cells from cell death induced by CDDP/PEM via CDKN1A-CDK1-mediated cell-cycle arrest and KEAP1-NRF2-SLC7A11/NQO1-mediated ferroptosis, thus resulting in chemoresistance in multiple LUAD cells both in vitro and in vivo.	Pemetrexed	95-98	cyclin dependent kinase 1	Homo sapiens	110-114
35170591-7	2022	The augmented therapeutic efficacy appeared to be associated with the concomitant suppression of prosurvival CDK1 and anti-apoptotic proteins including CDK9, cFLIP, MCL-1, BCL-2 and Survivin by Dina@EV-T treatment.	ev-t	199-203	cyclin dependent kinase 1	Homo sapiens	109-113
35392228-6	2022	In the present course of investigation, PKM2 modulation did not influence Cdk7 activity, but phosphotyrosine binding forms of PKM2 co-immunoprecipitated with pY15-containing Cdk1-cyclinB and enhanced formation of active pT161 Cdk1-cyclin B complexes.	Phosphotyrosine	93-108	cyclin dependent kinase 1	Homo sapiens	226-230
35370663-10	2022	Astragalus polysaccharides has the characteristics of multi-targets and multi-pathways, and its mechanism of action may be through regulating the expression of VCAM1, RELA, CDK2, JUN, CDK1, HSP90AA1, NOS2, SOD1, CASP3, AHSA1, PTGER3 and other genes during the development of pulmonary fibrosis.	astragalus polysaccharides	0-26	cyclin dependent kinase 1	Homo sapiens	184-188
35134645-0	2022	Identification of a promising hit from a new series of pyrazolo(1,5-a)pyrimidine based compounds as a potential anticancer agent with potent CDK1 inhibitory and pro-apoptotic properties through a multistep in vitro assessment.	pyrazolo(1,5-a)pyrimidine	55-80	cyclin dependent kinase 1	Homo sapiens	141-145
35134645-9	2022	The molecular docking study revealed a unique binding mode at the ATP binding pocket of CDK1/Cyc B/Cks2 through its 2,4-dimethoxyphenyl-amino.	Adenosine Triphosphate	66-69	cyclin dependent kinase 1	Homo sapiens	88-92
35072590-2	2022	These arrests are strictly regulated by follicular cells temporally producing the secondary messengers, cAMP and cGMP, and other factors to regulate maturation promoting factor (composed of cyclin B1 and cyclin-dependent kinase 1) levels in the oocytes.	Cyclic AMP	104-108	cyclin dependent kinase 1	Homo sapiens	204-229
35072590-2	2022	These arrests are strictly regulated by follicular cells temporally producing the secondary messengers, cAMP and cGMP, and other factors to regulate maturation promoting factor (composed of cyclin B1 and cyclin-dependent kinase 1) levels in the oocytes.	Cyclic GMP	113-117	cyclin dependent kinase 1	Homo sapiens	204-229
35134436-5	2022	The transcriptome analysis shows that the p53 signaling pathway is the most enriched cellular pathway and EG affects the proliferation of HCT 116 cells through modulating cell cycle related genes, such as CDKN1A and Cyclin-dependent kinases (CDKs).	anthraglycoside B	106-108	cyclin dependent kinase 1	Homo sapiens	242-246
35363355-0	2022	Effects of miR-490-5p targeting CDK1 on proliferation and apoptosis of colon cancer cells via ERK signaling pathway.	mir-490-5p	11-21	cyclin dependent kinase 1	Homo sapiens	32-36
35363355-14	2022	According to the results of Western blotting, the activation of ERK signaling pathway and the protein expression of CDK1 were significantly suppressed by overexpression of miR-490-5p (p<0.05).	mir-490-5p	172-182	cyclin dependent kinase 1	Homo sapiens	116-120
35363355-17	2022	In addition, overexpression of miR-490-5p inhibited the proliferation and promoted the apoptosis of colon cancer cells via down-regulating CDK1 both in vitro and in vivo.	mir-490-5p	31-41	cyclin dependent kinase 1	Homo sapiens	139-143
35134436-6	2022	We demonstrate that the protein expression level of p21 was up-regulated, and CDK1/CDK2 were reduced significantly in both HCT 116 and SH-SY5Y cells after EG treatment.	anthraglycoside B	155-157	cyclin dependent kinase 1	Homo sapiens	78-82
35134436-7	2022	The switch from hypo- to hyper-phosphorylated Retinoblastoma (Rb), which is believed as a result of activated CDKs, was inhibited when cells were treated with EG.	anthraglycoside B	159-161	cyclin dependent kinase 1	Homo sapiens	110-114
35167649-7	2022	These data proved that EPO promotes the proliferation of U251 cells by activating the PI3K-IKKalpha-CDK1 signaling pathway under CoC12-induced hypoxia.	coc12	129-134	cyclin dependent kinase 1	Homo sapiens	100-104
35441158-7	2022	Multiple alterations in E2-mediated cell cycle control were identified in the endocrine-resistant cell lines including increased expression of MYC, cyclin A1, cyclin D1, cyclin-dependent kinase 1 (CDK1), CDK2, and hyperphosphorylated retinoblastoma protein (ppRb), whereas p21 and p27 were reduced.	Estradiol	24-26	cyclin dependent kinase 1	Homo sapiens	170-195
35441158-7	2022	Multiple alterations in E2-mediated cell cycle control were identified in the endocrine-resistant cell lines including increased expression of MYC, cyclin A1, cyclin D1, cyclin-dependent kinase 1 (CDK1), CDK2, and hyperphosphorylated retinoblastoma protein (ppRb), whereas p21 and p27 were reduced.	Estradiol	24-26	cyclin dependent kinase 1	Homo sapiens	197-201
35371306-5	2022	In addition, we found that DDX21 directly recruited WDR5 to enhance trimethylation of histone H3 on Lys 4 (H3K4me3) on the CDK1 promoter.	Lysine	100-103	cyclin dependent kinase 1	Homo sapiens	123-127
35220396-6	2022	Treatment with DDK inhibitors dramatically reduced the rate of replication, prolonged S-phase, and led to a pronounced increase in phospho-CDC2 (Y15), indicating delay of mitotic entry.	1,2,4,5-benzenetetraamine	145-148	cyclin dependent kinase 1	Homo sapiens	139-143
35163825-6	2022	Furthermore, we demonstrate that inhibitor-treated adipocytes exhibit an enhanced insulin-stimulated glucose uptake as compared with untreated adipocytes, and that this outcome is dependent on the cyclin-dependent kinase 1 (CDK1) activity.	Glucose	101-108	cyclin dependent kinase 1	Homo sapiens	224-228
35163511-6	2022	MHY2245 induced G2/M phase cell cycle arrest via the downregulation of cyclin B1, cell division cycle protein 2 (Cdc2), and Cdc25c.	mhy2245	0-7	cyclin dependent kinase 1	Homo sapiens	82-111
35118741-8	2022	The expressions of CDK1, BCL2, MYC, and survivin were reduced, while the expressions of BAX and PARP were increased in DDZ treated cells.	daidzin	119-122	cyclin dependent kinase 1	Homo sapiens	19-23
35115540-3	2022	We show here that DENR is phosphorylated on Serine 73 by Cyclin B/CDK1 and Cyclin A/CDK2 at the onset of mitosis, and then dephosphorylated as cells exit mitosis.	Serine	44-50	cyclin dependent kinase 1	Homo sapiens	66-70
35163511-6	2022	MHY2245 induced G2/M phase cell cycle arrest via the downregulation of cyclin B1, cell division cycle protein 2 (Cdc2), and Cdc25c.	mhy2245	0-7	cyclin dependent kinase 1	Homo sapiens	113-117
35155443-3	2021	Paralog diversifications in the PSTAIRE, activation loop substrate binding platform, ATP entrance site, hinge region, and main Cyclin binding interface, have undergone positive selection to subdivide ancestral CDK1 functions along the S-M phase cell cycle axis.	Adenosine Triphosphate	85-88	cyclin dependent kinase 1	Homo sapiens	210-214
35517877-0	2022	Fibronectin within Sodium Alginate Microcapsules Improved Osteogenic Differentiation of BMMSCs in Dose Dependent Manner by Targeting SP7, OCN, CDK1, ZBTB16, and Twist1 Expression.	Alginates	19-34	cyclin dependent kinase 1	Homo sapiens	143-147
35078445-12	2022	In vitro, we further confirmed that curcumin significantly downregulated the expression of AURKA, CDK1, and TOP2A genes, while significantly upregulated the expression of CYP2B6, CYP2C9, and CYP3A4 genes.	Curcumin	36-44	cyclin dependent kinase 1	Homo sapiens	98-102
35078445-13	2022	CONCLUSIONS: Our results provided a novel panel of AURKA, CDK1, TOP2A, CYP2C9, and CYP3A4 candidate genes for curcumin related chemotherapy of hepatocellular carcinoma.	Curcumin	110-118	cyclin dependent kinase 1	Homo sapiens	58-62
35068399-4	2022	OBJECTIVE: The anticancer potential of multitarget CDK inhibitor riviciclib (also known as P276-00), was investigated against CRC cell lines of varied genetic background.	P276-00	65-75	cyclin dependent kinase 1	Homo sapiens	51-54
35068399-5	2022	METHOD: Cytotoxicity of riviciclib - potent CDK1, CDK4 and CDK9-specific inhibitor was evaluated in vitro.	P276-00	24-34	cyclin dependent kinase 1	Homo sapiens	44-48
35090330-17	2022	Furthermore, Western blot results tentatively revealed that gigantol may inhibit HCC progression through the HSP90/Akt/CDK1 pathway.	gigantol	60-68	cyclin dependent kinase 1	Homo sapiens	119-123
35056723-8	2022	The molecular mechanism of action of low-dose 7HF in TNBC cells primarily involved G2/M-phase arrest through upregulation of the expression of Bub3, cyclin B1, phosphorylated Cdk1 (Tyr 15) and p53-independent p21.	7alpha-hydroxyfrullanolide	46-49	cyclin dependent kinase 1	Homo sapiens	175-179
35056723-8	2022	The molecular mechanism of action of low-dose 7HF in TNBC cells primarily involved G2/M-phase arrest through upregulation of the expression of Bub3, cyclin B1, phosphorylated Cdk1 (Tyr 15) and p53-independent p21.	Tyrosine	181-184	cyclin dependent kinase 1	Homo sapiens	175-179
35056691-6	2022	In addition, naringenin induced cell cycle arrest in osteosarcoma cells by inhibiting cyclin B1 and cyclin-dependent kinase 1 expression and upregulating p21 expression.	naringenin	13-23	cyclin dependent kinase 1	Homo sapiens	100-125
2462672-2	1988	In HeLa cells, cdc2 is shown to be the most abundant phosphotyrosine-containing protein and its phosphotyrosine content is subject to cell-cycle regulation.	Phosphotyrosine	53-68	cyclin dependent kinase 1	Homo sapiens	15-19
35412245-7	2022	We employed an "analog-sensitive" Cdk1 to bio-orthogonally and uniquely label its substrates in the NE with a phosphate analog tag.	Phosphates	110-119	cyclin dependent kinase 1	Homo sapiens	34-38
2574724-5	1989	MPF activation after OA injection was associated with dephosphorylation of phosphothreonine and phosphoserine residues in cdc2, showing that neither type 1 nor 2A protein phosphatases catalyzes these dephosphorylations.	Phosphothreonine	75-91	cyclin dependent kinase 1	Homo sapiens	122-126
2574724-5	1989	MPF activation after OA injection was associated with dephosphorylation of phosphothreonine and phosphoserine residues in cdc2, showing that neither type 1 nor 2A protein phosphatases catalyzes these dephosphorylations.	Phosphoserine	96-109	cyclin dependent kinase 1	Homo sapiens	122-126
2668271-0	1989	Regulation of the product of a possible human cell cycle control gene CDC2Hs in B-cells by alpha-interferon and phorbol ester.	Phorbol Esters	112-125	cyclin dependent kinase 1	Homo sapiens	70-74
2668271-6	1989	Phorbol ester also inhibits the Daudi cell cycle in G1(G0) and causes the inhibition of p34CDC2Hs phosphorylation and a reduction of CDC2Hs mRNA.	Phorbol Esters	0-13	cyclin dependent kinase 1	Homo sapiens	88-95
2668271-6	1989	Phorbol ester also inhibits the Daudi cell cycle in G1(G0) and causes the inhibition of p34CDC2Hs phosphorylation and a reduction of CDC2Hs mRNA.	Phorbol Esters	0-13	cyclin dependent kinase 1	Homo sapiens	91-95
2538242-5	1989	Clam cdc2 and the associated cyclins bind to p13suc1-Sepharose.	Sepharose	53-62	cyclin dependent kinase 1	Homo sapiens	5-9
2462672-3	1988	One site of cdc2 tyrosine phosphorylation in vivo is selectively phosphorylated by pp60c-src in vitro.	Tyrosine	17-25	cyclin dependent kinase 1	Homo sapiens	12-16
33962568-0	2021	Phosphorylation of islet-1 serine 269 by CDK1 increases its transcriptional activity and promotes cell proliferation in gastric cancer.	Serine	27-33	cyclin dependent kinase 1	Homo sapiens	41-45
33982750-6	2021	Increased CDK1 expression was confirmed in HNSCC cells, and menadione, the top predicted potential drug, exerted significant inhibitory effects against HNSCC cell proliferation and markedly reversed CDK1 expression.	Vitamin K 3	60-69	cyclin dependent kinase 1	Homo sapiens	199-203
3297353-6	1987	Peptide mapping of p34cdc2, p36CDC28, and human p34 revealed complete conservation of four tryptophan residues in the three proteins.	Tryptophan	91-101	cyclin dependent kinase 1	Homo sapiens	19-26
33960273-8	2021	In addition, exogenous trehalose decreased the transcriptional levels of CycD2 and CDC2 (two genes regulating cell cycle progression) under heat stress, and reduced the activity of vacuolar invertase after recovery from heat stress, thereby shortening the cell length.	Trehalose	23-32	cyclin dependent kinase 1	Homo sapiens	83-87
34043345-8	2021	The accumulated G2/M phase cells with increasing levels of phosphorylated CDC25C, CDC2, ATM/ATR, and CHK2/CHK1 confirmed the arrested cell cycle caused by bavachinin via a dose-dependent manner.	bavachinin	155-165	cyclin dependent kinase 1	Homo sapiens	74-78
33962568-5	2021	Western blot and immunohistochemistry analyses were performed to evaluate the ability of CDK1 to phosphorylate ISL1 at Ser 269 in GC cell and tissue specimens.	Serine	119-122	cyclin dependent kinase 1	Homo sapiens	89-93
33962568-8	2021	RESULTS: ISL1 is phosphorylated by CDK1 at serine 269 (S269) in vivo.	Serine	43-49	cyclin dependent kinase 1	Homo sapiens	35-39
33962568-9	2021	Phosphorylation of ISL1 by CDK1 on serine 269 strengthened its binding on the cyclin B1 and cyclin B2 promoters and increased its transcriptional activity in GC.	Serine	35-41	cyclin dependent kinase 1	Homo sapiens	27-31
33727226-6	2021	CDK1 was critically required for advanced GIST, including imatinib-resistant GIST.	Imatinib Mesylate	58-66	cyclin dependent kinase 1	Homo sapiens	0-4
32948832-7	2021	Computational analysis and in vitro assays identified CDK1, one of the most promising lethal targets for KRAS-mutant cancer, as a target of miR-34c-3p.	mir-34c-3p	140-150	cyclin dependent kinase 1	Homo sapiens	54-58
32948832-8	2021	Moreover, the combination of CDK1 inhibition (mediated by RO3306) and miR-34c-3p overexpression resulted in an additive effect on the viability of KRASmut-expressing cells.	RO 3306	58-64	cyclin dependent kinase 1	Homo sapiens	29-33
33727226-10	2021	Importantly, a pharmacological inhibitor of CDK1, RO-3306, disrupted GIST cell proliferation in CDK1 highly expressed GIST but not in CDK1-negative GIST cells and non-transformed fibroblast cells.	RO 3306	50-57	cyclin dependent kinase 1	Homo sapiens	44-48
33727226-10	2021	Importantly, a pharmacological inhibitor of CDK1, RO-3306, disrupted GIST cell proliferation in CDK1 highly expressed GIST but not in CDK1-negative GIST cells and non-transformed fibroblast cells.	RO 3306	50-57	cyclin dependent kinase 1	Homo sapiens	96-100
33787085-10	2021	Mechanically, TAB182 interacts with FHL2 to induce G2-M arrest through wiring the CHK2/CDC25C/CDC2 signaling pathway.	tab182	14-20	cyclin dependent kinase 1	Homo sapiens	87-91
33727226-10	2021	Importantly, a pharmacological inhibitor of CDK1, RO-3306, disrupted GIST cell proliferation in CDK1 highly expressed GIST but not in CDK1-negative GIST cells and non-transformed fibroblast cells.	RO 3306	50-57	cyclin dependent kinase 1	Homo sapiens	96-100
32816920-4	2021	We evaluated the ability of the cyclin-dependent kinase (CDK) inhibitor dinaciclib to block IFNG-induced IDO1 and CD274 expression in 24 human and mouse cancer cell lines as well as in primary cancer cells from patients with PDAC or ovarian carcinoma.	dinaciclib	72-82	cyclin dependent kinase 1	Homo sapiens	57-60
32816920-10	2021	CDK1/2/5 inhibition by dinaciclib provides a novel strategy to overcome IFNG-triggered acquired resistance in pancreatic tumour immunity.	dinaciclib	23-33	cyclin dependent kinase 1	Homo sapiens	0-8
33684621-5	2021	We performed immunofluorescence and flow cytometry analysis to investigate DNA damage responses in human tumor cells during low and high dose treatments with RO-3306, a selective CDK1 inhibitor.	RO 3306	158-165	cyclin dependent kinase 1	Homo sapiens	179-183
33512038-4	2021	SBT-A treatment caused cell cycle arrest and decreased the expression of cyclin B1, cyclin D1, p-Cdc2, and p-Cdc25C.	scutebarbatine A	0-5	cyclin dependent kinase 1	Homo sapiens	97-101
33953844-6	2021	PL effectively inhibited cell growth, impacted the cell cycle by decreasing the level of cyclins and CDK1 and increasing CDKN1A and triggered a caspase-3 independant cell death process in which reactive oxygen species (ROS) production is a major player.	piperlonguminine	0-2	cyclin dependent kinase 1	Homo sapiens	101-105
33964993-2	2021	Our results showed that COP inhibited the cell viability and proliferation of EC cells, and COP induced G2/M phase arrest of EC cells and decreased the expression of claudin-2, p-cdc2, CDK1 and cyclin B1.	coptisine	92-95	cyclin dependent kinase 1	Homo sapiens	179-183
33964993-2	2021	Our results showed that COP inhibited the cell viability and proliferation of EC cells, and COP induced G2/M phase arrest of EC cells and decreased the expression of claudin-2, p-cdc2, CDK1 and cyclin B1.	coptisine	92-95	cyclin dependent kinase 1	Homo sapiens	185-189
33931002-3	2021	The present study aims at identifying the selective inhibitors for ATP binding site in CDK proteins (CDK1, CDK2, CDK4, and CDK5) following a multi-target drug designing approach.	Adenosine Triphosphate	67-70	cyclin dependent kinase 1	Homo sapiens	87-90
33931002-3	2021	The present study aims at identifying the selective inhibitors for ATP binding site in CDK proteins (CDK1, CDK2, CDK4, and CDK5) following a multi-target drug designing approach.	Adenosine Triphosphate	67-70	cyclin dependent kinase 1	Homo sapiens	101-105
33932512-14	2021	Furthermore, CMC downregulated CCNB1 and CDK1 expressions and induced G2/M phase cell cycle arrest.	cmc	13-16	cyclin dependent kinase 1	Homo sapiens	41-45
33925873-4	2021	Flow cytometric and Western blot analysis showed that ilimaquinone induced S-phase arrest by modulating the expression of p-CDC-2 and p21.	ilimaquinone	54-66	cyclin dependent kinase 1	Homo sapiens	124-129
33910135-8	2021	Phenanthrene also affected the expression of CDK (the coding gene of cyclin-dependent kinase) and CDC2 (a gene regulating cell division cycle), the key genes in the cell cycle of pericycle cells, thereby affecting the occurrence and growth of lateral roots.	phenanthrene	0-12	cyclin dependent kinase 1	Homo sapiens	98-102
33924053-1	2021	Previous studies have investigated the inhibitory effect of BMI-1026 on cyclin-dependent kinase 1 in vitro.	BMI 1026	60-68	cyclin dependent kinase 1	Homo sapiens	72-97
33879459-7	2021	In vivo AT7519 inhibited the phosphorylation of CDK1, 2, 7 and 9 substrates and suppressed growth of xenografts from 5 pancreatic cancer patients.	4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide	8-14	cyclin dependent kinase 1	Homo sapiens	48-52
33994848-0	2021	Upregulation of ATP Binding Cassette Subfamily C Member 5 facilitates Prostate Cancer progression and Enzalutamide resistance via the CDK1-mediated AR Ser81 Phosphorylation Pathway.	enzalutamide	102-114	cyclin dependent kinase 1	Homo sapiens	134-138
33875938-12	2021	Further analysis revealed that the mRNA and protein expression of caspase-3, caspase-8, and caspase-9 in the A. paniculata polysaccharide treatment groups increased significantly compared with that in the control groups, while the expression of CDK1 and cyclinB1 decreased significantly.	Polysaccharides	123-137	cyclin dependent kinase 1	Homo sapiens	245-249
33524522-7	2021	Finally, molecular dynamics simulations were performed of the complexes between Si113 or Si306 and the active site of both CDK 1 and 2.	CHEMBL1775042	80-85	cyclin dependent kinase 1	Homo sapiens	123-134
33524522-7	2021	Finally, molecular dynamics simulations were performed of the complexes between Si113 or Si306 and the active site of both CDK 1 and 2.	CHEMBL3394092	89-94	cyclin dependent kinase 1	Homo sapiens	123-134
33994848-9	2021	Moreover, the addition of a CDK1 inhibitor or knockdown of CDK1 significantly improved the efficacy of enzalutamide on prostate cancer cells.	enzalutamide	103-115	cyclin dependent kinase 1	Homo sapiens	28-32
33994848-9	2021	Moreover, the addition of a CDK1 inhibitor or knockdown of CDK1 significantly improved the efficacy of enzalutamide on prostate cancer cells.	enzalutamide	103-115	cyclin dependent kinase 1	Homo sapiens	59-63
33994848-10	2021	The ABCC5-CDK1-AR regulatory pathway could be a potential therapeutic target for advanced prostate cancer, especially castration-resistant prostate cancer (CRPC), to enhance the therapeutic effect of enzalutamide.	enzalutamide	200-212	cyclin dependent kinase 1	Homo sapiens	10-14
33898511-7	2021	However, without overexpression of miRISC components, when treating CC cells with 1,6-hexanediol(1,6-HD), a widely used LLPS inhibitor, the silence effects of miR-490-3p to CDK1 were totally abolished, no matter in RNA, protein or luciferase levels, suggesting that miRISC functions in an LLPS-depend way under biological condition.	hexamethylene glycol	82-96	cyclin dependent kinase 1	Homo sapiens	173-177
33869031-13	2021	AZD1775 inhibited phospho-CDC2 and increased the expression of gammaH2AX that was either maintained or enhanced after combination with SN38 or 5-FU.	adavosertib	0-7	cyclin dependent kinase 1	Homo sapiens	26-30
33898511-0	2021	MiR-490-3p Silences CDK1 and Inhibits the Proliferation of Colon Cancer Through an LLPS-Dependent miRISC System.	mir-490-3p	0-10	cyclin dependent kinase 1	Homo sapiens	20-24
33548356-7	2021	We further showed that gefitinib treatment increased phosphorylation of CDK1 at the site of Try15, inhibited cyclin B1 entry into the nucleus, and disrupted normal spindle assembly, chromosome alignment and mitochondria dynamics, finally leading to the generation of aneuploidy and early apoptosis of oocytes.	Gefitinib	23-32	cyclin dependent kinase 1	Homo sapiens	72-76
33611192-6	2021	The molecular modeling illustrated that compound DC-K2in212 had the similar binding mode with CDK2 as C-73, the most selective CDK2 inhibitor reported so far, which might account for selectivity against CDK2 over CDK1.	dc-k2in212	49-59	cyclin dependent kinase 1	Homo sapiens	213-217
33611192-6	2021	The molecular modeling illustrated that compound DC-K2in212 had the similar binding mode with CDK2 as C-73, the most selective CDK2 inhibitor reported so far, which might account for selectivity against CDK2 over CDK1.	Carbon	50-51	cyclin dependent kinase 1	Homo sapiens	213-217
33556637-6	2021	Subsequently, we found that after rescuing TPX2, all related proteins and phenotype changes were restored, and this effect can be inhibited by CDK1 inhibitor, RO-3306.	RO 3306	159-166	cyclin dependent kinase 1	Homo sapiens	143-147
33707466-0	2021	CDK1 is up-regulated by temozolomide in an NF-kappaB dependent manner in glioblastoma.	Temozolomide	24-36	cyclin dependent kinase 1	Homo sapiens	0-4
33744866-7	2021	miR-590-3p simultaneously bound to SNHG4 and CDK1.	mir-590-3p	0-10	cyclin dependent kinase 1	Homo sapiens	45-49
33744866-8	2021	miR-590-3p functioned to inhibit CDK1 expression.	mir-590-3p	0-10	cyclin dependent kinase 1	Homo sapiens	33-37
33796458-0	2021	High Iodine Induces the Proliferation of Papillary and Anaplastic Thyroid Cancer Cells via AKT/Wee1/CDK1 Axis.	Iodine	5-11	cyclin dependent kinase 1	Homo sapiens	100-104
33796458-4	2021	The transcriptome analysis showed that there were 295 differentially expressed genes (DEGs) in BCPAP and 8305C cells induced by high iodine, among which CDK1 expression associated with the proliferation of thyroid cancer cells induced by high iodine.	Iodine	133-139	cyclin dependent kinase 1	Homo sapiens	153-157
33796458-4	2021	The transcriptome analysis showed that there were 295 differentially expressed genes (DEGs) in BCPAP and 8305C cells induced by high iodine, among which CDK1 expression associated with the proliferation of thyroid cancer cells induced by high iodine.	Iodine	243-249	cyclin dependent kinase 1	Homo sapiens	153-157
33796458-5	2021	Moreover, the western blot analysis revealed that cells exposed to high iodine enhanced the phosphorylation activation of AKT and the expression of phospho-Wee1 (Ser642), while decreasing the expression of phospho-CDK1 (Tyr15).	Iodine	72-78	cyclin dependent kinase 1	Homo sapiens	214-218
33796458-6	2021	Importantly, the inhibition of AKT phosphorylation revered the expression of CDK1 induced by high iodine and arrested the cell cycle in the G1 phase, decreasing the proliferation of thyroid cancer cells induced by high iodine.	Iodine	98-104	cyclin dependent kinase 1	Homo sapiens	77-81
33796458-6	2021	Importantly, the inhibition of AKT phosphorylation revered the expression of CDK1 induced by high iodine and arrested the cell cycle in the G1 phase, decreasing the proliferation of thyroid cancer cells induced by high iodine.	Iodine	219-225	cyclin dependent kinase 1	Homo sapiens	77-81
33796458-7	2021	Taken together, these findings suggested that high iodine induced the proliferation of thyroid cancer cells through AKT-mediated Wee1/CDK1 axis, which provided new insights into the regulation of proliferation of thyroid cancer cells by iodine.	Iodine	51-57	cyclin dependent kinase 1	Homo sapiens	134-138
33796458-7	2021	Taken together, these findings suggested that high iodine induced the proliferation of thyroid cancer cells through AKT-mediated Wee1/CDK1 axis, which provided new insights into the regulation of proliferation of thyroid cancer cells by iodine.	Iodine	237-243	cyclin dependent kinase 1	Homo sapiens	134-138
33707466-2	2021	The anti-glioma effect of TMZ involves a complex response that includes G2-M cell cycle arrest and cyclin-dependent kinase 1 (CDK1) activation.	Temozolomide	26-29	cyclin dependent kinase 1	Homo sapiens	99-124
33707466-2	2021	The anti-glioma effect of TMZ involves a complex response that includes G2-M cell cycle arrest and cyclin-dependent kinase 1 (CDK1) activation.	Temozolomide	26-29	cyclin dependent kinase 1	Homo sapiens	126-130
33707466-3	2021	While CDK1 phosphorylation is a well-described consequence of TMZ treatment, we find that TMZ also robustly induces CDK1 expression.	Temozolomide	62-65	cyclin dependent kinase 1	Homo sapiens	6-10
33707466-3	2021	While CDK1 phosphorylation is a well-described consequence of TMZ treatment, we find that TMZ also robustly induces CDK1 expression.	Temozolomide	90-93	cyclin dependent kinase 1	Homo sapiens	116-120
33707466-8	2021	Targeted knockdown of CDK1 or chemical inhibition with the selective CDK1 inhibitor, RO-3306, potentiated the cytotoxic effect of TMZ.	RO 3306	85-92	cyclin dependent kinase 1	Homo sapiens	22-26
33707466-8	2021	Targeted knockdown of CDK1 or chemical inhibition with the selective CDK1 inhibitor, RO-3306, potentiated the cytotoxic effect of TMZ.	RO 3306	85-92	cyclin dependent kinase 1	Homo sapiens	69-73
33707466-8	2021	Targeted knockdown of CDK1 or chemical inhibition with the selective CDK1 inhibitor, RO-3306, potentiated the cytotoxic effect of TMZ.	Temozolomide	130-133	cyclin dependent kinase 1	Homo sapiens	22-26
33707466-8	2021	Targeted knockdown of CDK1 or chemical inhibition with the selective CDK1 inhibitor, RO-3306, potentiated the cytotoxic effect of TMZ.	Temozolomide	130-133	cyclin dependent kinase 1	Homo sapiens	69-73
33707466-9	2021	These results identify CDK1 as an NF-kappaB target gene regulated by p50 and BCL-3 and suggest that targeting CDK1 may be a strategy to improve the efficacy of TMZ against GBM.	Temozolomide	160-163	cyclin dependent kinase 1	Homo sapiens	23-27
33707466-9	2021	These results identify CDK1 as an NF-kappaB target gene regulated by p50 and BCL-3 and suggest that targeting CDK1 may be a strategy to improve the efficacy of TMZ against GBM.	Temozolomide	160-163	cyclin dependent kinase 1	Homo sapiens	110-114
33602509-5	2021	Additionally, 2,6-DMBQ induced G2 phase cell cycle arrest through inhibiting the expression and phosphorylation of cyclin B1 and CDC2, respectively.	2,6-dimethoxy-1,4-benzoquinone	14-22	cyclin dependent kinase 1	Homo sapiens	129-133
33658794-11	2021	Consistently, ouabain treatment induced cell cycle arrest at G2/M phase in both A375 and SK-Mel-28 cells via upregulation of cyclin B1 and downregulation of cdc2 and cdc25c.	Ouabain	14-21	cyclin dependent kinase 1	Homo sapiens	157-161
33678326-12	2021	12e treatment resulted in G2/M arrest through down modulation of cyclin B1 and cdk1.	3mrt	0-3	cyclin dependent kinase 1	Homo sapiens	79-83
33122847-11	2021	Consequently, acetyl-bufalin impaired the complex formation of CDK9 and STAT3, decreased the expressions of P-STAT3, and transcribed target genes such as cyclin B1, CDC2, MCL-1, Survivin, VEGF, BCL2, and it upregulated the expression levels of BAX and caspase-3 activity.	acetyl-bufalin	14-28	cyclin dependent kinase 1	Homo sapiens	165-169
33628636-15	2021	In addition, quercetin, which has the most targets, can act on the main targets (BAX, CDK1, CCNB1, SERPINE1, CHEK2, and IGFBP3) of the P53 pathway to treat HCC.	Quercetin	13-22	cyclin dependent kinase 1	Homo sapiens	86-90
33593912-2	2021	EZH2 protein can be phosphorylated at various residues, such as threonine 487 (T487), by CDK1 kinase, and such phosphorylation acts as a Polycomb repressive complex 2 (PRC2) suppression "code" to mediate the gene repressor-to-activator switch of EZH2 functions.	Threonine	64-73	cyclin dependent kinase 1	Homo sapiens	89-93
33574676-0	2021	Sinomenine Inhibits the Growth of Ovarian Cancer Cells Through the Suppression of Mitosis by Down-Regulating the Expression and the Activity of CDK1.	sinomenine	0-10	cyclin dependent kinase 1	Homo sapiens	144-148
33574676-12	2021	The results of Western blot showed the expression level of CDK1, which was the highest degree gene in PPI and the main regulator controlling the process of mitosis, and the levels of phosphorylated P-CDK (Thr161) and P-Histone H3 (Ser10) were decreased after being treated with sinomenine.	sinomenine	278-288	cyclin dependent kinase 1	Homo sapiens	59-63
33574676-13	2021	Conclusion: Our results demonstrated that sinomenine inhibited the proliferation of HeyA8 cells through suppressing mitosis by down-regulating the expression and the activity of CDK1.	sinomenine	42-52	cyclin dependent kinase 1	Homo sapiens	178-182
33465289-3	2021	v-Src directly phosphorylates Tyr-15 of cyclin-dependent kinase 1 (CDK1), thereby causing mitotic slippage and reduction in Eg5 inhibitor cytotoxicity.	Tyrosine	30-33	cyclin dependent kinase 1	Homo sapiens	40-65
33465289-3	2021	v-Src directly phosphorylates Tyr-15 of cyclin-dependent kinase 1 (CDK1), thereby causing mitotic slippage and reduction in Eg5 inhibitor cytotoxicity.	Tyrosine	30-33	cyclin dependent kinase 1	Homo sapiens	67-71
33732767-3	2021	Here, we describe an in vitro CDK1 kinase assay to detect CENP-C phosphorylation using Phos-tag SDS-PAGE without radiolabeled ATP.	phos	87-91	cyclin dependent kinase 1	Homo sapiens	30-34
33429982-7	2021	Specific inhibition of roscovitine majors target CDK 1, 2, 5, 7, and 9 showed that these CDKs played key roles in inflammatory processes of NVU cells and leucocytes after brain lesions, including ischemic stroke.	Roscovitine	23-34	cyclin dependent kinase 1	Homo sapiens	49-70
33732767-3	2021	Here, we describe an in vitro CDK1 kinase assay to detect CENP-C phosphorylation using Phos-tag SDS-PAGE without radiolabeled ATP.	Sodium Dodecyl Sulfate	96-99	cyclin dependent kinase 1	Homo sapiens	30-34
33732767-3	2021	Here, we describe an in vitro CDK1 kinase assay to detect CENP-C phosphorylation using Phos-tag SDS-PAGE without radiolabeled ATP.	Adenosine Triphosphate	126-129	cyclin dependent kinase 1	Homo sapiens	30-34
33394232-10	2021	The up-regulation of p21 and down-regulation of Cyclin-A1, Cyclin-B1, and Cdk-1 revealed the G2/M phase arrest mechanism of acacetin and apigenin.	acacetin	124-132	cyclin dependent kinase 1	Homo sapiens	74-79
32451414-7	2021	RNA-sequencing analyses revealed that avasimibe suppressed the expression of CDK2, cyclin E1, CDK4, cyclin D, CDK1, cyclin B1, Aurora A, and PLK1, while induced the expression of p53, p21, p27, and GADD45A, which was validated by Western blot analysis.	avasimibe	38-47	cyclin dependent kinase 1	Homo sapiens	110-114
33394232-10	2021	The up-regulation of p21 and down-regulation of Cyclin-A1, Cyclin-B1, and Cdk-1 revealed the G2/M phase arrest mechanism of acacetin and apigenin.	Apigenin	137-145	cyclin dependent kinase 1	Homo sapiens	74-79
33327489-4	2020	ABN-B also induced cell cycle arrest at G2/M by down-regulating the expression of CKD1 (cyclin-dependent kinase 1) and cyclin B1, but up-regulating p21 (cyclin-dependent kinase inhibitor 1) expression.	albanol B	0-5	cyclin dependent kinase 1	Homo sapiens	88-113
33380837-9	2020	Then, CDK1 was silenced by transfection with short hairpin RNA (shRNA)-CDK-1 or by exposure to CDK1 inhibitor p2767-00.	p2767-00	110-118	cyclin dependent kinase 1	Homo sapiens	6-10
33380837-9	2020	Then, CDK1 was silenced by transfection with short hairpin RNA (shRNA)-CDK-1 or by exposure to CDK1 inhibitor p2767-00.	p2767-00	110-118	cyclin dependent kinase 1	Homo sapiens	95-99
33039730-12	2021	PPT dose-dependently induced G2/M cell cycle arrest, as shown by the downregulation of cyclin B1 and cdc2, and upregulation of p27 expression in HCC827GR cells.	Podophyllotoxin	0-3	cyclin dependent kinase 1	Homo sapiens	101-105
33854565-10	2020	Treatment of ovarian cancer cells with ATR specific siRNA or ATR inhibitor VE-822 led to significant apoptosis and inhibition of cellular proliferation, with reduced phosphorylation of Chk1 (p-Chk1), Cdc25c (p-Cdc25c), Cdc2 (p-Cdc2), and increased expression of cleaved PARP and gammaH2AX.	berzosertib	75-81	cyclin dependent kinase 1	Homo sapiens	200-204
33854565-10	2020	Treatment of ovarian cancer cells with ATR specific siRNA or ATR inhibitor VE-822 led to significant apoptosis and inhibition of cellular proliferation, with reduced phosphorylation of Chk1 (p-Chk1), Cdc25c (p-Cdc25c), Cdc2 (p-Cdc2), and increased expression of cleaved PARP and gammaH2AX.	berzosertib	75-81	cyclin dependent kinase 1	Homo sapiens	210-214
33414996-11	2020	High throughput signalling analysis showed that one cluster of stress-associated kinase proteins including p53, ROCK1 and JNK were suppressed, while the mitotic checkpoint protein-serine kinases CDK1 and CDK2 were activated, as a consequence of the DHX36 knockdown.	Serine	180-186	cyclin dependent kinase 1	Homo sapiens	195-199
33321903-8	2020	Infigratinib/Bevacizumab promoted apoptosis, inhibited cell proliferation concomitant with upregulation of p27, and reduction in the expression of FGFR2-4, p-FRS-2, p-ERK1/2, p-p70S6K/4EBP1, Cdc25C, survivin, p-Cdc2, and p-Rb.	infigratinib	0-12	cyclin dependent kinase 1	Homo sapiens	191-195
33287214-6	2020	In RWPE-1 cells, arecoline increased the expression of cyclin-dependent kinase (CDK)-1, p21, and cyclins B1 and D3, decreased the expression of CDK2, and had no effects on CDK4 and cyclin D1 expression.	Arecoline	17-26	cyclin dependent kinase 1	Homo sapiens	55-86
33260954-0	2020	Design, Synthesis, and Molecular Docking of Paracyclophanyl-Thiazole Hybrids as Novel CDK1 Inhibitors and Apoptosis Inducing Anti-Melanoma Agents.	paracyclophanyl-thiazole	44-68	cyclin dependent kinase 1	Homo sapiens	86-90
33212312-15	2020	Docking studies on CDK1 revealed that the active molecules bind to the tested enzyme by the same manner of the co-crystallized ligands and the isatin-thiazoldinone/ene scaffold is essential for binding of these molecules.	isatin-thiazoldinone	143-163	cyclin dependent kinase 1	Homo sapiens	19-23
33212312-15	2020	Docking studies on CDK1 revealed that the active molecules bind to the tested enzyme by the same manner of the co-crystallized ligands and the isatin-thiazoldinone/ene scaffold is essential for binding of these molecules.	ene	164-167	cyclin dependent kinase 1	Homo sapiens	19-23
32895488-4	2020	meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.	mer342	0-6	cyclin dependent kinase 1	Homo sapiens	37-41
33125153-11	2020	In conclusion, the CDK1/2/5/9 inhibitor dinaciclib, irreversible pan-HER TKI afatinib and SRC targeting TKI dasatinib were most effective at inhibiting the proliferation and migration of HPCCLs and the combination of afatinib with dasatinib and gemcitabine with dasatinib led to synergistic tumor growth inhibition in all HPCCLs examined.	dinaciclib	40-50	cyclin dependent kinase 1	Homo sapiens	19-29
33125153-11	2020	In conclusion, the CDK1/2/5/9 inhibitor dinaciclib, irreversible pan-HER TKI afatinib and SRC targeting TKI dasatinib were most effective at inhibiting the proliferation and migration of HPCCLs and the combination of afatinib with dasatinib and gemcitabine with dasatinib led to synergistic tumor growth inhibition in all HPCCLs examined.	Dasatinib	108-117	cyclin dependent kinase 1	Homo sapiens	19-29
33125153-11	2020	In conclusion, the CDK1/2/5/9 inhibitor dinaciclib, irreversible pan-HER TKI afatinib and SRC targeting TKI dasatinib were most effective at inhibiting the proliferation and migration of HPCCLs and the combination of afatinib with dasatinib and gemcitabine with dasatinib led to synergistic tumor growth inhibition in all HPCCLs examined.	Afatinib	217-225	cyclin dependent kinase 1	Homo sapiens	19-29
33125153-11	2020	In conclusion, the CDK1/2/5/9 inhibitor dinaciclib, irreversible pan-HER TKI afatinib and SRC targeting TKI dasatinib were most effective at inhibiting the proliferation and migration of HPCCLs and the combination of afatinib with dasatinib and gemcitabine with dasatinib led to synergistic tumor growth inhibition in all HPCCLs examined.	Dasatinib	231-240	cyclin dependent kinase 1	Homo sapiens	19-29
33125153-11	2020	In conclusion, the CDK1/2/5/9 inhibitor dinaciclib, irreversible pan-HER TKI afatinib and SRC targeting TKI dasatinib were most effective at inhibiting the proliferation and migration of HPCCLs and the combination of afatinib with dasatinib and gemcitabine with dasatinib led to synergistic tumor growth inhibition in all HPCCLs examined.	gemcitabine	245-256	cyclin dependent kinase 1	Homo sapiens	19-29
33125153-11	2020	In conclusion, the CDK1/2/5/9 inhibitor dinaciclib, irreversible pan-HER TKI afatinib and SRC targeting TKI dasatinib were most effective at inhibiting the proliferation and migration of HPCCLs and the combination of afatinib with dasatinib and gemcitabine with dasatinib led to synergistic tumor growth inhibition in all HPCCLs examined.	Dasatinib	231-240	cyclin dependent kinase 1	Homo sapiens	19-29
33260632-5	2020	The results showed that GSPs inhibited the viability of HepG2 cells in a time- and dose-dependent manner, induced apoptosis and G2/M phase cell cycle arrest, and regulated cell cycle-related proteins, cyclin B1, cyclin-dependent kinase 1, and p21.	Grape Seed Proanthocyanidins	24-28	cyclin dependent kinase 1	Homo sapiens	212-237
33336716-0	2020	Long noncoding RNA OR3A4 promotes cisplatin resistance of non-small cell lung cancer by upregulating CDK1.	Cisplatin	34-43	cyclin dependent kinase 1	Homo sapiens	101-105
33197745-0	2020	Transfer of miR-15a-5p by placental exosomes promotes pre-eclampsia progression by regulating PI3K/AKT signaling pathway via CDK1.	mir-15a-5p	12-22	cyclin dependent kinase 1	Homo sapiens	125-129
33197745-7	2020	Further investigation showed that exosomal miR-15a-5p inhibited the activation of the PI3K/AKT pathway by down-regulating CDK1, thus suppressing HTR-8/SVneo cell proliferation, invasion, and apoptosis.	mir-15a-5p	43-53	cyclin dependent kinase 1	Homo sapiens	122-126
33125152-5	2020	Analyses of cell cycle regulatory proteins showed that CCL113 treatment inhibited the activity of CDK1 in HeLa cells, possibly due to the decrease in the level of Cdc25B/C proteins and arrest in the M phase.	ccl113	55-61	cyclin dependent kinase 1	Homo sapiens	98-102
33125153-5	2020	Of all the agents examined, the CDK1/2/5/9 inhibitor, dinacicilib, was the most potent agent which inhibited the proliferation of all seven HPCCLs with IC50 values of <=10 nM, followed by SRC targeting TKI dasatinib (IC50 of <=258 nM), gemcitabine (IC50 of <=330 nM), stattic (IC50 of <=2 microM) and the irreversible pan-HER TKI afatinib (IC50 of <=2.95 microM).	dinacicilib	54-65	cyclin dependent kinase 1	Homo sapiens	32-42
33125153-5	2020	Of all the agents examined, the CDK1/2/5/9 inhibitor, dinacicilib, was the most potent agent which inhibited the proliferation of all seven HPCCLs with IC50 values of <=10 nM, followed by SRC targeting TKI dasatinib (IC50 of <=258 nM), gemcitabine (IC50 of <=330 nM), stattic (IC50 of <=2 microM) and the irreversible pan-HER TKI afatinib (IC50 of <=2.95 microM).	Dasatinib	206-215	cyclin dependent kinase 1	Homo sapiens	32-42
33125153-5	2020	Of all the agents examined, the CDK1/2/5/9 inhibitor, dinacicilib, was the most potent agent which inhibited the proliferation of all seven HPCCLs with IC50 values of <=10 nM, followed by SRC targeting TKI dasatinib (IC50 of <=258 nM), gemcitabine (IC50 of <=330 nM), stattic (IC50 of <=2 microM) and the irreversible pan-HER TKI afatinib (IC50 of <=2.95 microM).	gemcitabine	236-247	cyclin dependent kinase 1	Homo sapiens	32-42
33125153-5	2020	Of all the agents examined, the CDK1/2/5/9 inhibitor, dinacicilib, was the most potent agent which inhibited the proliferation of all seven HPCCLs with IC50 values of <=10 nM, followed by SRC targeting TKI dasatinib (IC50 of <=258 nM), gemcitabine (IC50 of <=330 nM), stattic (IC50 of <=2 microM) and the irreversible pan-HER TKI afatinib (IC50 of <=2.95 microM).	Afatinib	330-338	cyclin dependent kinase 1	Homo sapiens	32-42
33177877-0	2020	Inhibition of CDK1 Reverses the Resistance of 5-Fu in Colorectal Cancer.	Fluorouracil	46-50	cyclin dependent kinase 1	Homo sapiens	14-18
33184446-0	2020	Phosphorylation of NMDA receptors by cyclin B/CDK1 modulates calcium dynamics and mitosis.	Calcium	61-68	cyclin dependent kinase 1	Homo sapiens	46-50
33184446-6	2020	This transient calcium entry during mitosis was due to phosphorylation of the first intracellular loop of NMDAR (S584 of NR1 and S580 of NR2A) by cyclin B/CDK1.	Calcium	15-22	cyclin dependent kinase 1	Homo sapiens	155-159
33177877-4	2020	This study aimed to clarify the correlation between cyclin-dependent kinase 1 (CDK1) and 5-Fu-induced tumor resistance.	Fluorouracil	89-93	cyclin dependent kinase 1	Homo sapiens	52-77
33177877-4	2020	This study aimed to clarify the correlation between cyclin-dependent kinase 1 (CDK1) and 5-Fu-induced tumor resistance.	Fluorouracil	89-93	cyclin dependent kinase 1	Homo sapiens	79-83
33177877-5	2020	Materials and Methods: Cell proliferation and invasion experiments showed that down-regulation of CDK1 inhibited fluorouracil-resistant CRC cell proliferation.	Fluorouracil	113-125	cyclin dependent kinase 1	Homo sapiens	98-102
33177877-6	2020	The expression level of CDK1 was detected in 5-Fu-resistant CRC cells in vitro.	Fluorouracil	45-49	cyclin dependent kinase 1	Homo sapiens	24-28
31932202-10	2020	U0126 pretreatment and co-incubation attenuated the bFGF-induced proliferation, cdc2, cyclin B1 and TIMP-1 proteins" expression, but not type I collagen in SCAP.	U 0126	0-5	cyclin dependent kinase 1	Homo sapiens	80-84
32854577-7	2020	RESULTS: The results suggest that the efficacy of HCQ against SLE is mainly associated with the targets of cyclin-dependent kinase 2 (CDK2), estrogen receptor alpha (ESR1) and CDK1, which regulate PI3K/Akt/GSK3beta as well as interferon (IFN) signaling pathway.	Hydroxychloroquine	50-53	cyclin dependent kinase 1	Homo sapiens	176-180
32854577-11	2020	Three key targets (CDK2, ESR1 and CDK1) involving 1766 proteins become the multi-targets mechanism of HCQ in the treatment of SLE.	Hydroxychloroquine	102-105	cyclin dependent kinase 1	Homo sapiens	34-38
33078103-8	2020	Following its intervention in the cell cycle pathway, SA can inhibit the expression of CDK1 and CyclinB1 at the mRNA and protein levels, and block cells in the G2/M phase.	sodium aescinate	54-56	cyclin dependent kinase 1	Homo sapiens	87-91
33145401-9	2020	It was also showed that RBM7 could directly bind to the AU-rich elements (AREs) in 3"-UTR of CDK1 mRNA, which contributed to the stability of CDK1 mRNA by lengthening its half-life.	Gold	56-58	cyclin dependent kinase 1	Homo sapiens	93-97
33145401-9	2020	It was also showed that RBM7 could directly bind to the AU-rich elements (AREs) in 3"-UTR of CDK1 mRNA, which contributed to the stability of CDK1 mRNA by lengthening its half-life.	Gold	56-58	cyclin dependent kinase 1	Homo sapiens	142-146
32721630-6	2020	Further studies found that CCT128930 triggered significant G-1 phase arrest and apoptosis, as convinced by the dysfunction of p27, Cyclin B1, Cyclin D1 and Cdc2, and PARP cleavage and caspase-3 activation.	4-(4-chlorobenzyl)-1-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)piperidin-4-amine	27-36	cyclin dependent kinase 1	Homo sapiens	156-160
33193609-8	2020	Taken together, our findings revealed the essential significance of the MC-LR and ctHBx on the PP2A/MAPK/p53, cdc25C and cdc2 axis in the formation and development of HCC and identified MC-LR and ctHBx as potential causal cofactors of hepatocarcinogenesis.	cyanoginosin LR	72-77	cyclin dependent kinase 1	Homo sapiens	110-114
32430958-3	2020	Treatment of melanoma cells with corynoline results in G2 cell arrest accompanied by reduced cdc2 activation.	corynoline	33-43	cyclin dependent kinase 1	Homo sapiens	93-97
32699966-1	2020	Two simple and novel fluorescent probes (CDC1 and CDC2) have been designed and prepared here for sensing HSO3- with large Stokes shifts (about 250 nm).	hydrogen sulfite	105-109	cyclin dependent kinase 1	Homo sapiens	50-54
32699966-4	2020	Besides, CDC1 and CDC2 can detect HSO3- in pure water and detection limits of CDC1 and CDC2 reached 4.59 nM and 8.19 nM, respectively.	Water	48-53	cyclin dependent kinase 1	Homo sapiens	18-22
32699966-4	2020	Besides, CDC1 and CDC2 can detect HSO3- in pure water and detection limits of CDC1 and CDC2 reached 4.59 nM and 8.19 nM, respectively.	Water	48-53	cyclin dependent kinase 1	Homo sapiens	87-91
30887847-5	2020	Results were further supported by in-silico molecular docking of pulchranin A to CDK1, CDK2, and CDK4 crystal structures, where it demonstrated good interactions by H-bonding, hydrophobic and Pi-Pi interactions with different amino acid residues of these enzymes.	pulchranin a	65-77	cyclin dependent kinase 1	Homo sapiens	81-85
30887847-6	2020	Pulchranin A might be a potential CDK inhibitor in human breast cancer cells.	pulchranin a	0-12	cyclin dependent kinase 1	Homo sapiens	34-37
32729622-4	2020	Under ROS scavenging conditions, induction of DNA double-strand breaks (DSBs) increases the NRF2 protein level and recruits NRF2 to DNA damage sites where it interacts with ATR, resulting in activation of the ATR-CHK1-CDC2 signaling pathway.	Reactive Oxygen Species	6-9	cyclin dependent kinase 1	Homo sapiens	218-222
32944844-5	2020	METHODS: In the present study, we used the carboxylated graphene oxide (CGO) conjugated with trimethyl chitosan (TMC) and hyaluronate (HA) nanoparticles (NPs) loaded with HIF-1alpha-siRNA and Dinaciclib, the CDK inhibitor, for silencing HIF-1alpha and blockade of CDKs in CD44-expressing cancer cells and evaluated the impact of combination therapy on proliferation, metastasis, apoptosis, and tumor growth.	ha	135-137	cyclin dependent kinase 1	Homo sapiens	264-268
32900880-4	2020	We found that cyclin-dependent kinase 1 (CDK1) phosphorylated a threonine residue on the catalytic subunit of the phosphatase PP2A, which disrupted its holoenzyme formation with the regulatory subunit B55.	Threonine	64-73	cyclin dependent kinase 1	Homo sapiens	14-39
32944844-5	2020	METHODS: In the present study, we used the carboxylated graphene oxide (CGO) conjugated with trimethyl chitosan (TMC) and hyaluronate (HA) nanoparticles (NPs) loaded with HIF-1alpha-siRNA and Dinaciclib, the CDK inhibitor, for silencing HIF-1alpha and blockade of CDKs in CD44-expressing cancer cells and evaluated the impact of combination therapy on proliferation, metastasis, apoptosis, and tumor growth.	carboxylated graphene oxide	43-70	cyclin dependent kinase 1	Homo sapiens	264-268
32944844-5	2020	METHODS: In the present study, we used the carboxylated graphene oxide (CGO) conjugated with trimethyl chitosan (TMC) and hyaluronate (HA) nanoparticles (NPs) loaded with HIF-1alpha-siRNA and Dinaciclib, the CDK inhibitor, for silencing HIF-1alpha and blockade of CDKs in CD44-expressing cancer cells and evaluated the impact of combination therapy on proliferation, metastasis, apoptosis, and tumor growth.	cgo	72-75	cyclin dependent kinase 1	Homo sapiens	264-268
32900880-4	2020	We found that cyclin-dependent kinase 1 (CDK1) phosphorylated a threonine residue on the catalytic subunit of the phosphatase PP2A, which disrupted its holoenzyme formation with the regulatory subunit B55.	Threonine	64-73	cyclin dependent kinase 1	Homo sapiens	41-45
32759885-4	2020	Then, the expression levels of CDK1 and CDCA5 in cancer tissues were estimated through Oncomine and The Cancer Genome Atlas (TCGA) database.	oncomine	87-95	cyclin dependent kinase 1	Homo sapiens	31-35
32485185-5	2020	A-24 showed dose-dependent cytotoxicity in SGC-7901 and AGS cell lines, it induced intrinsic mitochondrial pathway of apoptosis as well as autophagy, G2/M phase arrest and modulation of cyclinB1, p-cdc2, p-wee1 and p-Histone H3 expression.	a-24	0-4	cyclin dependent kinase 1	Homo sapiens	198-202
32811807-6	2020	Combination treatment of the CDKs inhibitor abemaciclib with metformin profoundly inhibited tumor viability in vitro and in vivo.	Metformin	61-70	cyclin dependent kinase 1	Homo sapiens	29-33
32811807-9	2020	Collectively, our study suggests that the combination of CDKs inhibitor with metformin could be recognized as a potential therapy in future clinical applications.	Metformin	77-86	cyclin dependent kinase 1	Homo sapiens	57-61
32255375-12	2020	Importantly, blocking the co-stimulatory OX40L-OX40 axis reduced Tfh-induction by control lung cDC2.	tfh	65-68	cyclin dependent kinase 1	Homo sapiens	95-99
32944399-9	2020	DDP, combined with ATF24-PEG-Lipo-beta-E, exerted a synergistic effect on cellular apoptosis and cell arrest at the G2/M phase, and these effects were dependent on the caspase-dependent pathway and Cdc25C/Cdc2/cyclin B1 pathways.	Cisplatin	0-3	cyclin dependent kinase 1	Homo sapiens	198-202
32773088-0	2020	An investigative study of antitumor properties of a novel thiazolo[4,5-d]pyrimidine small molecule revealing superior antitumor activity with CDK1 selectivity and potent pro-apoptotic properties.	thiazolo(3,2-a)perimidine	58-83	cyclin dependent kinase 1	Homo sapiens	142-146
30638055-3	2020	Valtrate induced cell cycle arrest at G2/M stage and apoptosis in MDA-MB-231 and MCF-7 cells, with reduced expression of p-Akt (Ser 473), cyclin B1 and caspase 8, and increased expression of p21, p-cdc2, cleaved-caspase 3, cleaved-caspase 7 and poly (ADP-ribose) polymerase (PARP).	valtrate	0-8	cyclin dependent kinase 1	Homo sapiens	198-202
32415712-2	2020	Development of CDK2 inhibitors has been extremely challenging as its ATP-binding site shares high similarity with CDK1, a related kinase whose inhibition causes toxic effects.	Adenosine Triphosphate	69-72	cyclin dependent kinase 1	Homo sapiens	114-118
32850387-4	2020	Vincristine-induced mitotic arrest was identified by Cdk1 activation (i.e., increased Cdk1Thr161 phosphorylation and decreased Cdk1Tyr15 phosphorylation), cyclin B1 upregulation, and increased phosphorylation of multiple mitotic proteins and stathmin.	Vincristine	0-11	cyclin dependent kinase 1	Homo sapiens	53-57
32759885-8	2020	The expression of CDK1 and CDCA5 in MGC-803 was positively related.	mgc-803	36-43	cyclin dependent kinase 1	Homo sapiens	18-22
32759812-3	2020	As disassembly is regulated by CDK1-mediated phosphorylation at serine 122, we generated a phosphomimetic S122E mutant called GFP-NE81-S122E-DeltaNLSDeltaCLIM.	Serine	64-70	cyclin dependent kinase 1	Homo sapiens	31-35
32647134-5	2020	We report that BRCAwt HGSOC develops resistance to prexasertib monotherapy via a prolonged G2 delay induced by lower CDK1/CyclinB1 activity, thus preventing cells from mitotic catastrophe and cell death.	prexasertib	51-62	cyclin dependent kinase 1	Homo sapiens	117-121
32234314-7	2020	cDC2 showed a higher capacity to phagocytose microspheres and to process DQ -OVA than cDC1, but none of these functions was affected by engagement of Siglec-3 and -5 with antibodies on blood cDC.	dq -ova	73-80	cyclin dependent kinase 1	Homo sapiens	0-4
32746792-6	2020	Restricting our analysis to the intersection in survival-related proteins between CPTAC and TCPA database revealed four coverage survival-related proteins including PCNA, MSH6, CDK1, and ASNS.	tcpa	92-96	cyclin dependent kinase 1	Homo sapiens	177-181
32915362-11	2020	The increase in berberine concentration led to an increase in miRNA-582-5p and miRNA-188-5p expression and a decrease in the expression of mRNA for the corresponding target genes encoding CDK1, CDK2, and cyclins D1 and A.	Berberine	16-25	cyclin dependent kinase 1	Homo sapiens	188-192
32627020-11	2020	Subsequently, TBMS1 inhibited DNA synthesis and induced G2/M phase arrest by targeting the PI3K/Akt/p21 and the cyclin-dependent kinase 1/cyclin B1 signaling cascades.	tubeimoside I	14-19	cyclin dependent kinase 1	Homo sapiens	112-137
32311864-9	2020	Results: AZD1775 blocked the phosphorylation of cdc2 and CDC25C in all cell lines, but significantly increased apoptosis and S phase arrest in sensitive cells.	adavosertib	9-16	cyclin dependent kinase 1	Homo sapiens	48-52
32220892-7	2020	AZD1775 significantly abrogated radiation-induced G2/M phase arrest and attenuation of p-CDK1-Y15.	adavosertib	0-7	cyclin dependent kinase 1	Homo sapiens	89-93
32559715-10	2020	CDK1, CDKN1A and TAPBP might serve as prognostic signature of resistance of HCC to sorafenib according to the survival analysis.	Sorafenib	83-92	cyclin dependent kinase 1	Homo sapiens	0-4
32591484-4	2020	Cdk1-mediated NuMA phosphorylation at Threonine 2055 negatively regulates its cortical localization.	Threonine	38-47	cyclin dependent kinase 1	Homo sapiens	0-4
32295844-7	2020	We demonstrate here that MYPT1 is O-GlcNAcylated at Thr-577, Ser-585, Ser-589, and Ser-601, which antagonizes CDK1-dependent phosphorylation at Ser-473 and attenuates the association between MYPT1 and PLK1, thereby promoting PLK1 activity.	Serine	61-64	cyclin dependent kinase 1	Homo sapiens	110-114
32575711-7	2020	Using CRISPR/Cas9 gene editing, we replaced endogenous BRD4 with a non-phosphorylatable mutant and demonstrated that CDK1-mediated BRD4 phosphorylation contributes to BETi resistance.	beti	167-171	cyclin dependent kinase 1	Homo sapiens	117-121
32575711-8	2020	CDK1 over-activation frequently observed in cancers has the potential to cause aberrant BRD4 hyperphosphorylation persisting outside of mitosis to strengthen its target gene binding and confer BETi resistance.	beti	193-197	cyclin dependent kinase 1	Homo sapiens	0-4
32575711-9	2020	We found that dual CDK1 and BET inhibition generates a synergistic effect in killing BETi-resistant cancer cells.	beti	85-89	cyclin dependent kinase 1	Homo sapiens	19-23
32575711-10	2020	Our study therefore suggests that CDK1 inhibition can be employed to overcome tumor BETi resistance and improve treatments for BRD4-associated cancers.	beti	84-88	cyclin dependent kinase 1	Homo sapiens	34-38
32506967-5	2022	BaP significantly increased the proportions of cells in S and G2/M phases, with concomitant reductions in the proportions of cells in G0/G1 phase, following 5 and 25 microM exposure, which was accompanied by the upregulation of the regulatory proteins cyclin A, cyclin B, cyclin-dependent kinase (CDK)1, and CDK2.	Benzo(a)pyrene	0-3	cyclin dependent kinase 1	Homo sapiens	272-302
32487663-5	2020	While Polo kinetics at DSBs are Cdk1-driven, Mre11 promptly but briefly associates with DSBs regardless of the phase of mitosis and re-associates with DSBs in the proceeding interphase.	1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione	23-27	cyclin dependent kinase 1	Homo sapiens	32-36
32377708-13	2020	DHC inhibited the production of proliferation- and anti-apoptosis-associated proteins CDK1, CCND1, BCL2 as well as that of the metastasis-associated proteins MMP2 and MMP9.	dehydrocorydalin	0-3	cyclin dependent kinase 1	Homo sapiens	86-90
32377708-16	2020	DHC exerted anticancer effects by downregulating cell proliferation, antiapoptosis, metastasis-associated proteins CDK1, CCND1, BCL2 and metastasis-associated proteins MMP2 and MMP9, and by upregulating the expression of proapoptotic proteins caspase 3/8/9.	dehydrocorydalin	0-3	cyclin dependent kinase 1	Homo sapiens	115-119
32512849-8	2020	Long-term everolimus treatment resulted in resistance development characterized by continued growth, and was associated with elevated Akt-mTOR signaling and cyclin-dependent kinase (CDK)1 phosphorylation and down-regulation of p19 and p27.	Everolimus	10-20	cyclin dependent kinase 1	Homo sapiens	157-187
32160976-4	2020	The anti-myeloma activity of DCZ0847 was associated with inhibition of cell proliferation; promotion of cell apoptosis via mitochondrial transmembrane potential collapse and caspase-mediated extrinsic or intrinsic apoptotic pathways; and the induction of G2/M phase arrest via downregulation of CDC25C, CDK1, and cyclin B1.	dcz0847	29-36	cyclin dependent kinase 1	Homo sapiens	303-307
32295844-7	2020	We demonstrate here that MYPT1 is O-GlcNAcylated at Thr-577, Ser-585, Ser-589, and Ser-601, which antagonizes CDK1-dependent phosphorylation at Ser-473 and attenuates the association between MYPT1 and PLK1, thereby promoting PLK1 activity.	Serine	70-73	cyclin dependent kinase 1	Homo sapiens	110-114
32295844-7	2020	We demonstrate here that MYPT1 is O-GlcNAcylated at Thr-577, Ser-585, Ser-589, and Ser-601, which antagonizes CDK1-dependent phosphorylation at Ser-473 and attenuates the association between MYPT1 and PLK1, thereby promoting PLK1 activity.	Serine	70-73	cyclin dependent kinase 1	Homo sapiens	110-114
32295844-7	2020	We demonstrate here that MYPT1 is O-GlcNAcylated at Thr-577, Ser-585, Ser-589, and Ser-601, which antagonizes CDK1-dependent phosphorylation at Ser-473 and attenuates the association between MYPT1 and PLK1, thereby promoting PLK1 activity.	Serine	70-73	cyclin dependent kinase 1	Homo sapiens	110-114
32414422-12	2020	Overexpression of miR-490-3p played an opposite role and reduced the effects of overexpression of TONSL -AS1 and CDK1.	mir-490-3p	18-28	cyclin dependent kinase 1	Homo sapiens	113-117
32547191-11	2020	Western blot results showed that DIOS significantly suppressed the expression levels of Bcl-2, cdc2, cyclinB1, and promoted the expression levels of Bax, cleaved-caspase3, cleaved-caspase8, cleaved-PARP, Bak, P53, and P21.	diosmetin	33-37	cyclin dependent kinase 1	Homo sapiens	95-99
32393310-9	2020	CDC25C, cyclin B1, and CDK1 expressions after CoCl2 treatment were lower than that in control cells.	cobaltous chloride	46-51	cyclin dependent kinase 1	Homo sapiens	23-27
32494162-10	2020	Luciferase reporter assay validated that cyclin-dependent kinase 1 (CDK1) was a potential binding target of miR-153-5p.	mir-153-5p	108-118	cyclin dependent kinase 1	Homo sapiens	41-66
32494162-10	2020	Luciferase reporter assay validated that cyclin-dependent kinase 1 (CDK1) was a potential binding target of miR-153-5p.	mir-153-5p	108-118	cyclin dependent kinase 1	Homo sapiens	68-72
32494162-11	2020	Moreover, overexpression of miR-153-5p prominently increased PTX-induced cell cycle arrest at G2/M phase in MDA-MB-231/PTX cells via downregulation of CDK1, cyclin B1 and p-Akt.	mir-153-5p	28-38	cyclin dependent kinase 1	Homo sapiens	151-155
32494162-11	2020	Moreover, overexpression of miR-153-5p prominently increased PTX-induced cell cycle arrest at G2/M phase in MDA-MB-231/PTX cells via downregulation of CDK1, cyclin B1 and p-Akt.	Paclitaxel	61-64	cyclin dependent kinase 1	Homo sapiens	151-155
32410646-8	2020	Xanthohumol inhibited the Akt-Wee1-CDK1 signaling, which in turn decreased survivin phosphorylation on Thr34, and facilitated E3 ligase Fbxl7-mediated survivin ubiquitination and degradation.	xanthohumol	0-11	cyclin dependent kinase 1	Homo sapiens	35-39
32170903-7	2020	The five hub-bottleneck genes related to graphene cytotoxicity; CDK1, CCNB1, PLK1, TOP2A, and CCNA2 were identified through network analysis, which were highly correlated with regulation of cell cycle processes.	Graphite	41-49	cyclin dependent kinase 1	Homo sapiens	64-68
32041019-7	2020	CDK1 and cyclin B, two G2/M cycle-related proteins, and CDK2, a G0/G1 cycle-related protein, were reduced in 1-NP-exposed trophoblasts.	1-nitropyrene	109-113	cyclin dependent kinase 1	Homo sapiens	0-4
32375399-8	2020	Dinaciclib was shown to drastically enhance EV-T killing effects on cancer lines that express good levels of death receptor (DR) 5, which are associated with suppression of CDK1, CDK9 and anti-apoptotic proteins.	dinaciclib	0-10	cyclin dependent kinase 1	Homo sapiens	173-177
32200332-9	2020	Moreover, docking study predicted that 3a, 3d, 3e and 7a can fit in the ATP binding site of CDK1 enzyme.	Adenosine Triphosphate	72-75	cyclin dependent kinase 1	Homo sapiens	92-96
31981797-5	2020	CDK1 phosphorylates PKN1 at S533, S537, S562, and S916 in vitro and in cells during drug-induced mitotic arrest.	1-bromo-1-(difluoromethoxy)-2,2,2-trifluoroethane	34-38	cyclin dependent kinase 1	Homo sapiens	0-4
32277442-9	2020	When the cells were synchronized and treated with gemcitabine at G2/M transition, the degradation of cyclin B1 and dephosphorylation of cdc-2 at Tyr 15 residue did not occur, resulting in cycle arrest.	gemcitabine	50-61	cyclin dependent kinase 1	Homo sapiens	136-141
31836849-6	2020	The strong 177Lu-lilotomab cytotoxicity observed in DOHH2 cells correlated with reduced G2/M cell cycle arrest, lower WEE-1- and MYT-1-mediated phosphorylation of cyclin-dependent kinase-1 (CDK1), and higher apoptosis.	((177)Lu)Lu-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(methane-phosphonic acid)	11-16	cyclin dependent kinase 1	Homo sapiens	163-188
31836849-6	2020	The strong 177Lu-lilotomab cytotoxicity observed in DOHH2 cells correlated with reduced G2/M cell cycle arrest, lower WEE-1- and MYT-1-mediated phosphorylation of cyclin-dependent kinase-1 (CDK1), and higher apoptosis.	((177)Lu)Lu-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(methane-phosphonic acid)	11-16	cyclin dependent kinase 1	Homo sapiens	190-194
31836849-8	2020	These results indicate that 177Lu-lilotomab is particularly efficient in treating tumors with reduced inhibitory CDK1 phosphorylation, such as transformed FL.	((177)Lu)Lu-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra(methane-phosphonic acid)	28-33	cyclin dependent kinase 1	Homo sapiens	113-117
32277442-9	2020	When the cells were synchronized and treated with gemcitabine at G2/M transition, the degradation of cyclin B1 and dephosphorylation of cdc-2 at Tyr 15 residue did not occur, resulting in cycle arrest.	Tyrosine	145-148	cyclin dependent kinase 1	Homo sapiens	136-141
32390841-6	2020	Attenuating the K+ channel function by applying the hERG1 channel inhibitor E4031 modulated Ca2+ signaling, impaired inhibition of the mitosis promoting subunit cdc2, overrode cell cycle arrest, and decreased clonogenic survival of the irradiated cells but did not affect repair of DNA double strand breaks suggesting a critical role of the hERG1 K+ channels for the Ca2+ signaling and the cell cycle control during DNA damage response.	E 4031	76-81	cyclin dependent kinase 1	Homo sapiens	161-165
32181475-6	2020	Knockdown of GINS2 reverses the effect of nocodazole on the levels of CDK1 and cyclin-B1.	Nocodazole	42-52	cyclin dependent kinase 1	Homo sapiens	70-74
32135139-11	2020	Interestingly, genes like CDK1 (Cyclin-dependent kinases 1) and RASSF2 (Ras association domain family member 2) observed to be differentially methylated and expressed which was further modulated by corosolic acid treatment, validated by qPCR.	corosolic acid	198-212	cyclin dependent kinase 1	Homo sapiens	26-30
32135139-11	2020	Interestingly, genes like CDK1 (Cyclin-dependent kinases 1) and RASSF2 (Ras association domain family member 2) observed to be differentially methylated and expressed which was further modulated by corosolic acid treatment, validated by qPCR.	corosolic acid	198-212	cyclin dependent kinase 1	Homo sapiens	32-58
31996318-7	2020	ART caused cell cycle arrest at G1 and/or G2/M phases, which was associated with decreased expression of cyclin dependent kinase 1/2/4/6, cyclin B1/D2/E and c-Myc, and increased expression of p21.	artesunate	0-3	cyclin dependent kinase 1	Homo sapiens	105-136
32112098-5	2020	Notably, acetylated MORC2 binds to histone H3 phosphorylation at threonine 11 (H3T11P) and is essential for DNA damage-induced reduction of H3T11P and transcriptional repression of its downstream target genes CDK1 and Cyclin B1, thus contributing to DNA damage-induced G2 checkpoint activation.	Threonine	65-74	cyclin dependent kinase 1	Homo sapiens	209-213
32537408-5	2020	The phosphorylation of EZH2 at the Thr-487 site by cyclin dependent kinase 1 (CDK1) is responsible for As-induced EZH2 protein degradation, and UCA1 enhances this process through increasing the interaction between CDK1 and EZH2.	Threonine	35-38	cyclin dependent kinase 1	Homo sapiens	51-76
32537408-5	2020	The phosphorylation of EZH2 at the Thr-487 site by cyclin dependent kinase 1 (CDK1) is responsible for As-induced EZH2 protein degradation, and UCA1 enhances this process through increasing the interaction between CDK1 and EZH2.	Threonine	35-38	cyclin dependent kinase 1	Homo sapiens	78-82
32537408-5	2020	The phosphorylation of EZH2 at the Thr-487 site by cyclin dependent kinase 1 (CDK1) is responsible for As-induced EZH2 protein degradation, and UCA1 enhances this process through increasing the interaction between CDK1 and EZH2.	Threonine	35-38	cyclin dependent kinase 1	Homo sapiens	214-218
32537408-5	2020	The phosphorylation of EZH2 at the Thr-487 site by cyclin dependent kinase 1 (CDK1) is responsible for As-induced EZH2 protein degradation, and UCA1 enhances this process through increasing the interaction between CDK1 and EZH2.	Arsenic	103-105	cyclin dependent kinase 1	Homo sapiens	51-76
32537408-5	2020	The phosphorylation of EZH2 at the Thr-487 site by cyclin dependent kinase 1 (CDK1) is responsible for As-induced EZH2 protein degradation, and UCA1 enhances this process through increasing the interaction between CDK1 and EZH2.	Arsenic	103-105	cyclin dependent kinase 1	Homo sapiens	78-82
32537408-5	2020	The phosphorylation of EZH2 at the Thr-487 site by cyclin dependent kinase 1 (CDK1) is responsible for As-induced EZH2 protein degradation, and UCA1 enhances this process through increasing the interaction between CDK1 and EZH2.	Arsenic	103-105	cyclin dependent kinase 1	Homo sapiens	214-218
31076964-0	2020	Identification of a 3,3-difluorinated tetrahydropyridinol compound as a novel antitumor agent for hepatocellular carcinoma acting via cell cycle arrest through disturbing CDK7-mediated phosphorylation of Cdc2.	3,3-difluorinated tetrahydropyridinol	20-57	cyclin dependent kinase 1	Homo sapiens	204-208
32337261-5	2020	Results: Curcumin was found to suppress the proliferation of LECs by inducing G2/M arrest via possible inhibition of cell cycle-related proteins including CDK1, cyclin B1, and CDC25C.	Curcumin	9-17	cyclin dependent kinase 1	Homo sapiens	155-159
32214089-2	2020	Here we report that hTERT is phosphorylated at threonine 249 during mitosis by the serine/threonine kinase CDK1.	Threonine	47-56	cyclin dependent kinase 1	Homo sapiens	107-111
32256113-8	2020	Oxymatrine induced cell cycle arrest in the G2/M phase by increasing the protein expression of P21 and decreasing levels of cyclin B1 and CDC2.	oxymatrine	0-10	cyclin dependent kinase 1	Homo sapiens	138-142
32204315-14	2020	Treatment with adavosertib as a single agent resulted in a decrease in p-CDC2 in a dose-dependent manner that was also observed in the combination treatment.	adavosertib	15-26	cyclin dependent kinase 1	Homo sapiens	73-77
32214089-2	2020	Here we report that hTERT is phosphorylated at threonine 249 during mitosis by the serine/threonine kinase CDK1.	Serine	83-89	cyclin dependent kinase 1	Homo sapiens	107-111
32040547-4	2020	Different pathways including eIF2alpha, 4EBP, and S6K1 signaling contribute to controlling global translation downstream of CDK1.	CisEBP protocol	40-44	cyclin dependent kinase 1	Homo sapiens	124-128
32152317-4	2020	Here, we find that CDC14B antagonizes CDK1-mediated activating mitotic phosphorylation of the deubiquitinase USP9X at serine residue 2563, which we show to be essential for USP9X to mediate mitotic survival.	Serine	118-124	cyclin dependent kinase 1	Homo sapiens	38-42
31866205-0	2020	Low-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 Cascade.	saturated fatty acid palmitate	10-40	cyclin dependent kinase 1	Homo sapiens	103-107
31707583-6	2020	LCH triggered G2/M-phase arrest by modulating expression levels of cdc2, cyclin B1, p21, and p27.	lithocholyl-N-hydroxysuccinimide	0-3	cyclin dependent kinase 1	Homo sapiens	67-71
31816347-6	2020	The Fe-complex treatment caused cell cycle arrest via the activation of ATM-ATR kinase mediated DNA damage response pathway with the compromised expression of CDK1, CDK2 and CyclinB1 protein in Trigonella seedlings.	Iron	4-6	cyclin dependent kinase 1	Homo sapiens	159-163
31922221-7	2020	In response to IFA treatment, the levels of cleaved poly(ADP-ribose) polymerase and cleaved caspase-3 were increased in Jurkat and K562 cells, which was associated with increased phosphorylation of Cdc2 and reduction of Cyclin B1 levels.	isoferulic acid	15-18	cyclin dependent kinase 1	Homo sapiens	198-202
31866205-5	2020	LPA-mediated mitochondrial homeostasis is regulated by CDK1-mediated SIRT3 phosphorylation, which in turn deacetylates and dimerizes CPT2 to enhance fatty acid oxidation.	lpa	0-3	cyclin dependent kinase 1	Homo sapiens	55-59
31866205-5	2020	LPA-mediated mitochondrial homeostasis is regulated by CDK1-mediated SIRT3 phosphorylation, which in turn deacetylates and dimerizes CPT2 to enhance fatty acid oxidation.	Fatty Acids	149-159	cyclin dependent kinase 1	Homo sapiens	55-59
31866205-6	2020	Thus, an advantageous effect is suggested by the consumption of LPA that augments mitochondrial metabolic homeostasis via CDK1-SIRT3-CPT2 cascade.	lpa	64-67	cyclin dependent kinase 1	Homo sapiens	122-126
31709755-5	2020	Tfcp2l1 was phosphorylated at Thr177 by Cdk1, which affected ESC cell cycle progression, pluripotency, and differentiation.	peptide T amide	30-36	cyclin dependent kinase 1	Homo sapiens	40-44
32020876-7	2020	Germacrone induced cell cycle arrest in the G2/M phase via remarkably decreased expression levels of cyclin B1, cdc 2 and cdc 25c.	germacrone	0-10	cyclin dependent kinase 1	Homo sapiens	112-117
31998078-7	2019	As a result, APalpha-induced an increase in the number of TH-positive SH-SY5Y cells might be mediated through GABAAR via Ca2+/CaM/CaMKIIdelta3/BDNF (CDK1) signaling pathway, which would ultimately facilitate to elucidate PD pathogenesis and hold a promise as an alternative therapeutic target for PD.	apalpha	13-20	cyclin dependent kinase 1	Homo sapiens	149-153
31672358-6	2020	The cellular changes following OTA treatment are examined, and the results show that OTA adversely affects oocyte polar body extrusion, which is confirmed by the delay of Cdc2-mediated cell cycle progression.	ochratoxin A	85-88	cyclin dependent kinase 1	Homo sapiens	171-175
32013837-7	2020	RESULTS: Here, we reported that pisosterol markedly induced G2/M arrest and apoptosis and decreased the cell viability and proliferation potential of glioma cells in a dose-dependent manner by increasing the expression of ATM, CASP3, CDK1, CDKN1A, CDKN2A, CDKN2B, CHEK1, p14ARF and TP53 and decreasing the expression of MYC, BCL2, BMI1 and MDM2.	pisosterol	32-42	cyclin dependent kinase 1	Homo sapiens	234-238
31653349-6	2020	Furthermore, inhibition of CDK1 by CGP74514A prevented TC11-induced MCL1 degradation, caspase-9 activation, and the subsequent apoptotic cell death.	TC11	55-59	cyclin dependent kinase 1	Homo sapiens	27-31
32401925-5	2020	Administration of beta-elemene+paclitaxel arrested SKOV3 cell cycle at S phase and down-regulated CDK1, cyclin-B1, and P27 gene expression and apoptotic-related resistant gene expression of MDR1, LRP, and TS in SKOV3 cells.	beta-elemene	18-30	cyclin dependent kinase 1	Homo sapiens	98-102
32401925-5	2020	Administration of beta-elemene+paclitaxel arrested SKOV3 cell cycle at S phase and down-regulated CDK1, cyclin-B1, and P27 gene expression and apoptotic-related resistant gene expression of MDR1, LRP, and TS in SKOV3 cells.	Paclitaxel	31-41	cyclin dependent kinase 1	Homo sapiens	98-102
31760882-7	2020	The amount of repressive phosphorylation of CDK1 at tyrosine 15 (Y15) was decreased by Chk1 inhibitor treatment.	Tyrosine	52-60	cyclin dependent kinase 1	Homo sapiens	44-48
31760882-8	2020	Moreover, we observed that co-expressing CDK1AF mutant, which is resistant to the repressive phosphorylation at threonine 14 and Y15, or cdc25A, which dephosphorylates CDK1 at Y15, suppressed the G2/M-phase arrest by CycADelta80 with E1A.	glycyl-threonine	112-121	cyclin dependent kinase 1	Homo sapiens	41-45
31746356-11	2020	Based on the present results, it is suggested that 2,3-DHBA and 2,5-DHBA may contribute to the chemopreventive properties of aspirin, possibly through the inhibition of CDKs.	2,5-dihydroxybenzoic acid	64-72	cyclin dependent kinase 1	Homo sapiens	169-173
32009123-0	2020	Erratum: Cyclin Dependent Kinase 1 (CDK1) Activates Cardiac Fibroblasts via Directly Phosphorylating Paxillin at Ser244.	seryl-seryl-seryl-arginine	113-116	cyclin dependent kinase 1	Homo sapiens	9-34
32009123-0	2020	Erratum: Cyclin Dependent Kinase 1 (CDK1) Activates Cardiac Fibroblasts via Directly Phosphorylating Paxillin at Ser244.	seryl-seryl-seryl-arginine	113-116	cyclin dependent kinase 1	Homo sapiens	36-40
32009123-1	2020	An error appeared in the article entitled "Cyclin Dependent Kinase 1 (CDK1) Activates Cardiac Fibroblasts via Directly Phosphorylating Paxillin at Ser244" by Chen Sai, Jiang Yunhan, Jian Zhao, Zhu Yu, Zhu Yun, Cao Zhezhe, Tang Fuqin, Xiao Yingbin, and Ma Ruiyan (Vol.	seryl-seryl-seryl-arginine	147-150	cyclin dependent kinase 1	Homo sapiens	43-68
32009123-1	2020	An error appeared in the article entitled "Cyclin Dependent Kinase 1 (CDK1) Activates Cardiac Fibroblasts via Directly Phosphorylating Paxillin at Ser244" by Chen Sai, Jiang Yunhan, Jian Zhao, Zhu Yu, Zhu Yun, Cao Zhezhe, Tang Fuqin, Xiao Yingbin, and Ma Ruiyan (Vol.	seryl-seryl-seryl-arginine	147-150	cyclin dependent kinase 1	Homo sapiens	70-74
31914610-10	2020	Furthermore, we observed that the UFM1 cascade could alter the level of phosphorylation on tyrosine-15 of CDK1 (pY15-CDK1), which is a negative regulator of the G2 to M transition.	Tyrosine	91-99	cyclin dependent kinase 1	Homo sapiens	106-110
31914610-10	2020	Furthermore, we observed that the UFM1 cascade could alter the level of phosphorylation on tyrosine-15 of CDK1 (pY15-CDK1), which is a negative regulator of the G2 to M transition.	Tyrosine	91-99	cyclin dependent kinase 1	Homo sapiens	117-121
31814282-6	2020	We found that mifepristone causes cell cycle arrest through inhibiting CDK1 and CDK2 expressions and induces cell apoptosis via the mitochondria-dependent signalling pathway in endometrial epithelial cells and stromal cells of adenomyosis.	Mifepristone	14-26	cyclin dependent kinase 1	Homo sapiens	71-75
31241436-6	2020	METHODS: CDK1 and CDK2 have 89.19% similar residues and 74.32% identical residues, their structures especially the ATP-binding sites are of great similarity.	Adenosine Triphosphate	115-118	cyclin dependent kinase 1	Homo sapiens	9-13
31746356-3	2020	In a previous study, we demonstrated that 2,3-DHBA and 2,5-DHBA inhibited CDK1 enzyme activity in vitro.	2,3-dihydroxybenzoic acid	42-50	cyclin dependent kinase 1	Homo sapiens	74-78
31746356-3	2020	In a previous study, we demonstrated that 2,3-DHBA and 2,5-DHBA inhibited CDK1 enzyme activity in vitro.	2,5-dihydroxybenzoic acid	55-63	cyclin dependent kinase 1	Homo sapiens	74-78
31746356-5	2020	Additionally, in silico studies were performed to determine the potential sites of interactions of 2,3-DHBA and 2,5-DHBA with CDKs.	2,3-dihydroxybenzoic acid	99-107	cyclin dependent kinase 1	Homo sapiens	126-130
31746356-5	2020	Additionally, in silico studies were performed to determine the potential sites of interactions of 2,3-DHBA and 2,5-DHBA with CDKs.	2,5-dihydroxybenzoic acid	112-120	cyclin dependent kinase 1	Homo sapiens	126-130
31746356-6	2020	We demonstrated that 2,3-DHBA and 2,5-DHBA inhibits CDK-1 enzyme activity beginning at 500 microM, while CDK2 and CDK4 activity was inhibited only at higher concentrations (>750 microM).	2,3-dihydroxybenzoic acid	21-29	cyclin dependent kinase 1	Homo sapiens	52-57
31746356-6	2020	We demonstrated that 2,3-DHBA and 2,5-DHBA inhibits CDK-1 enzyme activity beginning at 500 microM, while CDK2 and CDK4 activity was inhibited only at higher concentrations (>750 microM).	2,5-dihydroxybenzoic acid	34-42	cyclin dependent kinase 1	Homo sapiens	52-57
31746356-11	2020	Based on the present results, it is suggested that 2,3-DHBA and 2,5-DHBA may contribute to the chemopreventive properties of aspirin, possibly through the inhibition of CDKs.	2,3-dihydroxybenzoic acid	51-59	cyclin dependent kinase 1	Homo sapiens	169-173
31746356-11	2020	Based on the present results, it is suggested that 2,3-DHBA and 2,5-DHBA may contribute to the chemopreventive properties of aspirin, possibly through the inhibition of CDKs.	Aspirin	125-132	cyclin dependent kinase 1	Homo sapiens	169-173
31746435-6	2020	The treatment of human cholangiocarcinoma cell lines (CCKS-1, TFK-1 and HUCCT-1) with the multi-CDK inhibitor roscovitine decreased p-CDK1 expression, inhibited cell proliferation, arrested the cell cycle at the G1 or G2/M phase, and significantly inhibited carcinoma cell invasion.	Roscovitine	110-121	cyclin dependent kinase 1	Homo sapiens	134-138
31295040-6	2020	Furthermore, by cell cycle analysis and western blotting for cyclin B1, CDK1, and p21, hesperetin was found to induce cell-cycle arrest at G2/M phase.	hesperetin	87-97	cyclin dependent kinase 1	Homo sapiens	72-76
31881805-7	2019	Taken together, these findings reveal that the anti-proliferative activity of diosgenin involves the induction of G2/M phase arrest via modulating the Cdc25C-Cdc2-cyclin B pathway and mitochondria-mediated apoptosis in human breast cancer cell lines.	Diosgenin	78-87	cyclin dependent kinase 1	Homo sapiens	151-155
31885624-6	2019	The results from the present study show that PAME significantly reduced the levels of G2/M phase regulatory proteins, cyclin-dependent kinase 1 (Cdk1), and cyclin B1 and inhibited proliferation in hBM-MSCs.	methyl palmitate	45-49	cyclin dependent kinase 1	Homo sapiens	118-143
31822694-6	2019	Here we show that not only Cdk2 but Cdk1 phosphorylates p27 at the Thr-187.	Threonine	67-70	cyclin dependent kinase 1	Homo sapiens	36-40
31468634-5	2019	Furthermore, the Chk2-Cdc25c-Cdc2-cyclin B1 cascade was found to contribute to the cell cycle arrest, whereas the activation of mitochondrial pathway was involved in the cell apoptosis by 3"-DMAG.	3"-dmag	188-195	cyclin dependent kinase 1	Homo sapiens	22-26
31885624-6	2019	The results from the present study show that PAME significantly reduced the levels of G2/M phase regulatory proteins, cyclin-dependent kinase 1 (Cdk1), and cyclin B1 and inhibited proliferation in hBM-MSCs.	methyl palmitate	45-49	cyclin dependent kinase 1	Homo sapiens	145-149
31885624-13	2019	Taken together, these results suggest that PAME induced p53 stabilization, which in turn increased the levels of p53/p21 proteins and decreased the levels of Cdk1/cyclin B1 proteins, thereby preventing the activation of Cdk1, and eventually caused cell cycle arrest at the G2/M phase.	methyl palmitate	43-47	cyclin dependent kinase 1	Homo sapiens	158-162
31885624-13	2019	Taken together, these results suggest that PAME induced p53 stabilization, which in turn increased the levels of p53/p21 proteins and decreased the levels of Cdk1/cyclin B1 proteins, thereby preventing the activation of Cdk1, and eventually caused cell cycle arrest at the G2/M phase.	methyl palmitate	43-47	cyclin dependent kinase 1	Homo sapiens	220-224
31776402-5	2019	Here, we demonstrate that KDM5B is phosphorylated at Ser1456 by the cyclin-dependent kinase 1 (CDK1).	seryl-seryl-seryl-arginine	53-56	cyclin dependent kinase 1	Homo sapiens	68-93
31776402-5	2019	Here, we demonstrate that KDM5B is phosphorylated at Ser1456 by the cyclin-dependent kinase 1 (CDK1).	seryl-seryl-seryl-arginine	53-56	cyclin dependent kinase 1	Homo sapiens	95-99
31588915-5	2019	However, isorhamnetin increased expression of p21WAF1/CIP1, a cyclin-dependent kinase (Cdk) inhibitor, and increased p21 complexed with Cdk2 and Cdc2.	3-methylquercetin	9-21	cyclin dependent kinase 1	Homo sapiens	145-149
31712441-0	2019	WEE1 kinase inhibitor AZD1775 induces CDK1 kinase-dependent origin firing in unperturbed G1- and S-phase cells.	adavosertib	22-29	cyclin dependent kinase 1	Homo sapiens	38-42
31649888-3	2019	Atorvastatin inhibited K562 and HL60 cell proliferation, induced G2/M cell cycle arrest in K562 cells by down-regulating cyclinB1 and cdc2, but G0/G1 arrest in HL60 cells by up-regulating p27 and down-regulating cyclinD1 and p-pRb.	atorvastatin	0-12	cyclin dependent kinase 1	Homo sapiens	134-138
31328874-4	2019	Lysine-to-methionine point mutations at amino acid 27 (H3K27M) co-occur with alterations in signaling genes, including the receptor tyrosine kinases (PDGFR/KIT/VEGFR/MET/EGFR), activin A receptor (ACVR1), intracellular kinases (PI3K/AKT/mTOR), cyclin-dependent kinases (CDKs1/4/6), transcriptional regulators (MYCN), and tumor suppressors (PTEN/TP53).	Lysine	0-6	cyclin dependent kinase 1	Homo sapiens	270-279
31328874-4	2019	Lysine-to-methionine point mutations at amino acid 27 (H3K27M) co-occur with alterations in signaling genes, including the receptor tyrosine kinases (PDGFR/KIT/VEGFR/MET/EGFR), activin A receptor (ACVR1), intracellular kinases (PI3K/AKT/mTOR), cyclin-dependent kinases (CDKs1/4/6), transcriptional regulators (MYCN), and tumor suppressors (PTEN/TP53).	Methionine	10-20	cyclin dependent kinase 1	Homo sapiens	270-279
31398082-11	2019	Hair follicle biopsy samples demonstrated evidence of Wee1 inhibition with decreased phosphorylation of cyclin-dependent kinase 1 staining by immunohistochemistry after AZD1775 administration at the recommended phase II dose.	adavosertib	169-176	cyclin dependent kinase 1	Homo sapiens	104-129
31590241-4	2019	Our data showed that isorhamnetin decreased the expression of Wee1 and cyclin B1, but increased the expression of cyclin-dependent kinase (Cdk) inhibitor p21WAF1/CIP1, and increased p21 was bound to Cdk1.	3-methylquercetin	21-33	cyclin dependent kinase 1	Homo sapiens	199-203
31601054-5	2019	For this situation, actinomycin V decreased the M-phase related proteins (Cdc2, Cdc25A and Cyclin B1) expression, arrested cells in G2/M phase and subsequently triggered apoptosis by mediating the Bcl-2 family proteins" expression (Bax and Bcl-2).	Dactinomycin	20-31	cyclin dependent kinase 1	Homo sapiens	74-78
31506042-6	2019	Here we show that the reverse unidirectional coupling via phosphorylation of REV-ERBalpha or via mitotic inhibition of transcription, both controlled by CDK1, can elicit entrainment of the circadian clock by the cell cycle.	rev-erbalpha	77-89	cyclin dependent kinase 1	Homo sapiens	153-157
30797877-7	2019	Together, these results indicate that cyclin B1/CDK1 upregulation in cancer cells undergoing 2-methoxyestradiol-induced mitotic catastrophe causes apoptosis via Bcl-XL phosphorylation.	2-Methoxyestradiol	93-111	cyclin dependent kinase 1	Homo sapiens	48-52
30797877-0	2019	Upregulated cyclin B1/CDK1 mediates apoptosis following 2-methoxyestradiol-induced mitotic catastrophe: Role of Bcl-XL phosphorylation.	2-Methoxyestradiol	56-74	cyclin dependent kinase 1	Homo sapiens	22-26
30797877-2	2019	Earlier we showed that 2-methoxyestradiol increases the level and activity of cyclin B1/CDK1, which subsequently induces mitotic prometaphase arrest.	2-Methoxyestradiol	23-41	cyclin dependent kinase 1	Homo sapiens	88-92
30797877-3	2019	In the present study, we demonstrate that upregulation of cyclin B1/CDK1 is responsible for the increased phosphorylation of the anti-apoptotic proteins Bcl-2 and Bcl-XL in 2-methoxyestradiol-induced, mitotically-arrested cancer cells.	2-Methoxyestradiol	173-191	cyclin dependent kinase 1	Homo sapiens	68-72
31607295-8	2019	The study results also revealed that dehydrocostus lactone significantly inhibited the expression of BCR/ABL STAT3, STAT5, CyclinB1, CDK1 and BCL-2, and up-regulated the expression level of BAX and p21.	dehydrocostus lactone	37-58	cyclin dependent kinase 1	Homo sapiens	133-137
31434716-3	2019	Here, we show that human importin-alpha1 is regulated during the cell cycle and is phosphorylated at two sites (threonine 9 and serine 62) during mitosis by the major mitotic protein kinase CDK1-cyclin B. Mutational analysis indicates that the mitotic phosphorylation of importin-alpha1 inhibits its binding to importin-beta and promotes the release of TPX2 and KIFC1, which are then targeted like importin-beta to the spindle.	Threonine	112-121	cyclin dependent kinase 1	Homo sapiens	190-194
31434716-3	2019	Here, we show that human importin-alpha1 is regulated during the cell cycle and is phosphorylated at two sites (threonine 9 and serine 62) during mitosis by the major mitotic protein kinase CDK1-cyclin B. Mutational analysis indicates that the mitotic phosphorylation of importin-alpha1 inhibits its binding to importin-beta and promotes the release of TPX2 and KIFC1, which are then targeted like importin-beta to the spindle.	Serine	128-134	cyclin dependent kinase 1	Homo sapiens	190-194
31576145-4	2019	Results: When mitotic slippage happens, BEX can synergistically strengthen the anti-proliferation of DTX in a way of significantly down-regulating cyclinB1 and CDK1 expression, and then arresting cells in G2 phase.	bexarotene	40-43	cyclin dependent kinase 1	Homo sapiens	160-164
31253693-7	2019	An in vitro kinase assay revealed that PPA15 inhibited multiple CDKs involved in cell cycle regulation.	ppa15	39-44	cyclin dependent kinase 1	Homo sapiens	64-68
31576145-4	2019	Results: When mitotic slippage happens, BEX can synergistically strengthen the anti-proliferation of DTX in a way of significantly down-regulating cyclinB1 and CDK1 expression, and then arresting cells in G2 phase.	docetaxel	101-104	cyclin dependent kinase 1	Homo sapiens	160-164
31260568-6	2019	In contrast, G2/M cell cycle arrest in response to oxidative stress induced by hydrogen peroxide (H2 O2 ) was enhanced in KS keratinocytes but not KS-Kin1WT cells, following inhibition of CDK activity.	Hydrogen Peroxide	98-103	cyclin dependent kinase 1	Homo sapiens	188-191
31260568-7	2019	Furthermore, KS keratinocytes were more sensitive to DNA damage in response to H2 O2 and this was exacerbated by treatment with the CDK inhibitor roscovitine.	Hydrogen Peroxide	79-84	cyclin dependent kinase 1	Homo sapiens	132-135
31260568-7	2019	Furthermore, KS keratinocytes were more sensitive to DNA damage in response to H2 O2 and this was exacerbated by treatment with the CDK inhibitor roscovitine.	Roscovitine	146-157	cyclin dependent kinase 1	Homo sapiens	132-135
31322237-4	2019	Treatment with DP induced G2/M phase cell cycle arrest through upregulation of p21 and p27, and downregulation of cyclin B1 and Cdc2.	dracorhodin	15-17	cyclin dependent kinase 1	Homo sapiens	128-132
31452810-0	2019	Tanshinone IIA inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells via p53-cyclin B1/CDC2.	tanshinone	0-14	cyclin dependent kinase 1	Homo sapiens	118-122
31452810-3	2019	The present study aimed to investigate whether tanshinone IIA inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells via p53-cyclin B1/cell division cycle gene 2 (CDC2).	tanshinone	47-61	cyclin dependent kinase 1	Homo sapiens	193-197
31531359-0	2019	Structural Basis for the Selective Inhibition of Cdc2-Like Kinases by CX-4945.	silmitasertib	70-77	cyclin dependent kinase 1	Homo sapiens	49-53
31438633-3	2019	Genistein down-regulated the levels of cyclin A and cyclin B1, but up-regulated the levels of p21WAF1/CIP1, cyclin-dependent kinase (Cdk) inhibitor, that was complexed with Cdc2 and Cdk2.	Genistein	0-9	cyclin dependent kinase 1	Homo sapiens	173-177
31531359-1	2019	Cdc2-like kinases (CLKs) play a crucial role in the alternative splicing of eukaryotic pre-mRNAs through the phosphorylation of serine/arginine-rich proteins (SR proteins).	Serine	128-134	cyclin dependent kinase 1	Homo sapiens	0-4
31176784-0	2019	Lycorine inhibited the cell growth of non-small cell lung cancer by modulating the miR-186/CDK1 axis.	lycorine	0-8	cyclin dependent kinase 1	Homo sapiens	91-95
31176784-12	2019	Consistently, exposure of lycorine significantly decreased the expression of CDK1.	lycorine	26-34	cyclin dependent kinase 1	Homo sapiens	77-81
31176784-13	2019	Restoration of CDK1 remarkably attenuated the inhibition of lycorine on the proliferation of NSCLC cells.	lycorine	60-68	cyclin dependent kinase 1	Homo sapiens	15-19
31176784-14	2019	SIGNIFICANCE: Our results uncovered the novel molecular mechanism of lycorine in suppressing the progression of NSCLC partially via regulating the miR-186/CDK1 axis.	lycorine	69-77	cyclin dependent kinase 1	Homo sapiens	155-159
31404056-13	2019	Pancratistatin induced arrest of HCT-15 cells at G2/M of the cell cycle and inhibited phosphorylation of cdc2/cyclin-dependent kinase 1 (CDK1) and Cdc25c and the expression of cyclin B1.	pancratistatin	0-14	cyclin dependent kinase 1	Homo sapiens	105-135
31404056-13	2019	Pancratistatin induced arrest of HCT-15 cells at G2/M of the cell cycle and inhibited phosphorylation of cdc2/cyclin-dependent kinase 1 (CDK1) and Cdc25c and the expression of cyclin B1.	pancratistatin	0-14	cyclin dependent kinase 1	Homo sapiens	137-141
31387245-4	2019	Our data showed that LCA inhibited the expression of cyclin A, cyclin B1, and Wee1, but increased the expression of cyclin-dependent kinase (Cdk) inhibitor p21WAF1/CIP1, and increased p21 was bound to Cdc2 and Cdk2.	licochalcone A	21-24	cyclin dependent kinase 1	Homo sapiens	201-205
31406162-6	2019	Furthermore, in MDR cancer cells, danazol reduced STAT3 phosphorylation as well as the expression of STAT3-regulated genes involved in cell survival, such as c-Myc, CDC25, and CDK1.	Danazol	34-41	cyclin dependent kinase 1	Homo sapiens	176-180
31035050-16	2019	Fucosterol also triggered G2/M cell cycle arrest of the A549 and SK-LU-1 cells which was associated with decrease in the expression of Cdc2, Cyclin A, Cyclin B1 and upregulation of the negative regulators of cell cycle progression (p21Cip1, and p27Kip1).	fucosterol	0-10	cyclin dependent kinase 1	Homo sapiens	135-139
31375708-7	2019	DEX treatment induced CDK1 expression which was accompanied by reduced CDK1 methylation, indicating epigenetic regulation.	Dexamethasone	0-3	cyclin dependent kinase 1	Homo sapiens	22-26
31375708-7	2019	DEX treatment induced CDK1 expression which was accompanied by reduced CDK1 methylation, indicating epigenetic regulation.	Dexamethasone	0-3	cyclin dependent kinase 1	Homo sapiens	71-75
31497351-7	2019	Mechanistically, circ-ADD3 was capable of reinforcing the interaction between CDK1 and EZH2, resulting in increased EZH2 ubiquitination and subsequent degradation via phosphorylation at Thr-345 and Thr-487 sites.	Threonine	186-189	cyclin dependent kinase 1	Homo sapiens	78-82
31497351-7	2019	Mechanistically, circ-ADD3 was capable of reinforcing the interaction between CDK1 and EZH2, resulting in increased EZH2 ubiquitination and subsequent degradation via phosphorylation at Thr-345 and Thr-487 sites.	Threonine	198-201	cyclin dependent kinase 1	Homo sapiens	78-82
31201269-2	2019	Phosphorylation at Ser-83 of 4E-BP1 occurs during mitosis through the activity of cyclin-dependent kinase 1 (CDK1)/cyclin B rather than through canonical mTOR kinase activity.	Serine	19-22	cyclin dependent kinase 1	Homo sapiens	82-107
31201269-2	2019	Phosphorylation at Ser-83 of 4E-BP1 occurs during mitosis through the activity of cyclin-dependent kinase 1 (CDK1)/cyclin B rather than through canonical mTOR kinase activity.	Serine	19-22	cyclin dependent kinase 1	Homo sapiens	109-113
31207099-0	2019	Study of the mechanism by which dinaciclib induces apoptosis and cell cycle arrest of lymphoma Raji cells through a CDK1-involved pathway.	dinaciclib	32-42	cyclin dependent kinase 1	Homo sapiens	116-120
31207099-10	2019	It was revealed by cell transfection that the expression of cell cycle proteins was downregulated after treatment with dinaciclib through a CDK1-involved pathway, which eventually led to apoptosis.	dinaciclib	119-129	cyclin dependent kinase 1	Homo sapiens	140-144
31207099-13	2019	CONCLUSION: In this study, we clarified the mechanisms through which dinaciclib induces Raji cell apoptosis and blocks the cell cycle through a CDK1-involved pathway, which supported that dinaciclib had potential values in the treatment of lymphoma.	dinaciclib	69-79	cyclin dependent kinase 1	Homo sapiens	144-148
31207099-13	2019	CONCLUSION: In this study, we clarified the mechanisms through which dinaciclib induces Raji cell apoptosis and blocks the cell cycle through a CDK1-involved pathway, which supported that dinaciclib had potential values in the treatment of lymphoma.	dinaciclib	188-198	cyclin dependent kinase 1	Homo sapiens	144-148
31285549-0	2019	KIAA1429 acts as an oncogenic factor in breast cancer by regulating CDK1 in an N6-methyladenosine-independent manner.	N-methyladenosine	79-97	cyclin dependent kinase 1	Homo sapiens	68-72
31285549-10	2019	5"-fluorouracil was found to be very effective in reducing the expression of KIAA1429 and CDK1 in breast cancer.	Fluorouracil	0-15	cyclin dependent kinase 1	Homo sapiens	90-94
31295843-8	2019	PTX + PI3K inhibitor combined therapy showed a synergistic effect by strengthening paclitaxel-induced S and G2M arrest in PTX-R cell sublines by the inactivation of cyclin A1, cyclin B1, cyclin E, and Cdc2 expression.	Paclitaxel	0-3	cyclin dependent kinase 1	Homo sapiens	201-205
31295843-8	2019	PTX + PI3K inhibitor combined therapy showed a synergistic effect by strengthening paclitaxel-induced S and G2M arrest in PTX-R cell sublines by the inactivation of cyclin A1, cyclin B1, cyclin E, and Cdc2 expression.	Paclitaxel	83-93	cyclin dependent kinase 1	Homo sapiens	201-205
30514066-8	2019	AZD6738 significantly increased apoptosis, G2/M arrest and p21, and decreased CDC2.	ceralasertib	0-7	cyclin dependent kinase 1	Homo sapiens	78-82
31074773-13	2019	Liensinine could induce GBC cells G2/M phase arrest by up-regulating the levels of Cyclin B1 and CDK1 proteins.	liensinine	0-10	cyclin dependent kinase 1	Homo sapiens	97-101
31059083-11	2019	Compared with cisplatin alone, the combination increased levels of phospho-cyclin-dependent kinase 1 (Y15).	Cisplatin	14-23	cyclin dependent kinase 1	Homo sapiens	75-100
31164422-2	2019	Here, we reveal that cyclin-dependent kinase A;1 (CDKA;1), the homolog of human Cdk1 and Cdk2, is a major regulator of meiotic recombination in Arabidopsis Arabidopsis plants with reduced CDKA;1 activity experienced a decrease of class I COs, especially lowering recombination rates in centromere-proximal regions.	carbonyl sulfide	238-241	cyclin dependent kinase 1	Homo sapiens	80-84
30755439-7	2019	Alisertib caused spindle defects, G2-M arrest and inhibitory CDK1 phosphorylation, and cytostasis in TP53 mutant HNSCC FaDu and UNC7 cells.	MLN 8237	0-9	cyclin dependent kinase 1	Homo sapiens	61-65
31200459-2	2019	By phosphorylating cdk1 at tyrosine 15, Wee1 inhibits activation of cyclin B-cdk1 (Cdk1), preventing cells from entering mitosis with incompletely replicated or damaged DNA.	Tyrosine	27-35	cyclin dependent kinase 1	Homo sapiens	19-23
31200459-2	2019	By phosphorylating cdk1 at tyrosine 15, Wee1 inhibits activation of cyclin B-cdk1 (Cdk1), preventing cells from entering mitosis with incompletely replicated or damaged DNA.	Tyrosine	27-35	cyclin dependent kinase 1	Homo sapiens	77-81
31200459-2	2019	By phosphorylating cdk1 at tyrosine 15, Wee1 inhibits activation of cyclin B-cdk1 (Cdk1), preventing cells from entering mitosis with incompletely replicated or damaged DNA.	Tyrosine	27-35	cyclin dependent kinase 1	Homo sapiens	83-87
30848542-6	2019	In addition, Ost enhanced the levels of endoplasmic reticulum (ER) stress proteins (GRP78/Bip, CHOP, Caspase-4, IRE1alpha, PERK, JNK, P-JNK, and ATF4), decreased the cell proliferation and cycle-associated protein (Phospho-Histone H3, P-Cdc25C, Cdc25C, P-Cdc2, Cdc2, and Cyclin B1) level.	osthol	13-16	cyclin dependent kinase 1	Homo sapiens	237-241
30848542-6	2019	In addition, Ost enhanced the levels of endoplasmic reticulum (ER) stress proteins (GRP78/Bip, CHOP, Caspase-4, IRE1alpha, PERK, JNK, P-JNK, and ATF4), decreased the cell proliferation and cycle-associated protein (Phospho-Histone H3, P-Cdc25C, Cdc25C, P-Cdc2, Cdc2, and Cyclin B1) level.	osthol	13-16	cyclin dependent kinase 1	Homo sapiens	245-249
31285938-14	2019	Furthermore, the deactivated states of tyrosine phosphorylation of CDK1 (CDK1-Y15) and serine phosphorylation of Cdc25C (Cdc25C-S216) were upregulated after H. pylori infection.	Tyrosine	39-47	cyclin dependent kinase 1	Homo sapiens	67-71
31285938-14	2019	Furthermore, the deactivated states of tyrosine phosphorylation of CDK1 (CDK1-Y15) and serine phosphorylation of Cdc25C (Cdc25C-S216) were upregulated after H. pylori infection.	Tyrosine	39-47	cyclin dependent kinase 1	Homo sapiens	73-77
30872078-0	2019	Adefovir dipivoxil sensitizes colon cancer cells to vemurafenib by disrupting the KCTD12-CDK1 interaction.	adefovir	0-8	cyclin dependent kinase 1	Homo sapiens	89-93
30872078-0	2019	Adefovir dipivoxil sensitizes colon cancer cells to vemurafenib by disrupting the KCTD12-CDK1 interaction.	dipivoxil	9-18	cyclin dependent kinase 1	Homo sapiens	89-93
30872078-0	2019	Adefovir dipivoxil sensitizes colon cancer cells to vemurafenib by disrupting the KCTD12-CDK1 interaction.	Vemurafenib	52-63	cyclin dependent kinase 1	Homo sapiens	89-93
30872078-3	2019	We found that CDK1 is stably activated in the vemurafenib-resistant (VR) colon cancer sublines that we established, indicating that CDK1 activation is responsible for vemurafenib resistance.	Vemurafenib	46-57	cyclin dependent kinase 1	Homo sapiens	14-18
30872078-3	2019	We found that CDK1 is stably activated in the vemurafenib-resistant (VR) colon cancer sublines that we established, indicating that CDK1 activation is responsible for vemurafenib resistance.	Vemurafenib	46-57	cyclin dependent kinase 1	Homo sapiens	132-136
30872078-3	2019	We found that CDK1 is stably activated in the vemurafenib-resistant (VR) colon cancer sublines that we established, indicating that CDK1 activation is responsible for vemurafenib resistance.	Vemurafenib	167-178	cyclin dependent kinase 1	Homo sapiens	14-18
30872078-3	2019	We found that CDK1 is stably activated in the vemurafenib-resistant (VR) colon cancer sublines that we established, indicating that CDK1 activation is responsible for vemurafenib resistance.	Vemurafenib	167-178	cyclin dependent kinase 1	Homo sapiens	132-136
30872078-4	2019	As the KCTD12-CDK1 interaction is necessary for CDK1 activation, we screened an FDA-approved drug library consisting of 616 compounds and identified that adefovir dipivoxil (AD), a nucleoside analog for treatment of HBV infections, disrupts the CDK1-KCTD12 interaction and induces G2 phase arrest in the cell cycle.	adefovir dipivoxil	154-172	cyclin dependent kinase 1	Homo sapiens	14-18
30872078-4	2019	As the KCTD12-CDK1 interaction is necessary for CDK1 activation, we screened an FDA-approved drug library consisting of 616 compounds and identified that adefovir dipivoxil (AD), a nucleoside analog for treatment of HBV infections, disrupts the CDK1-KCTD12 interaction and induces G2 phase arrest in the cell cycle.	adefovir dipivoxil	154-172	cyclin dependent kinase 1	Homo sapiens	48-52
30872078-4	2019	As the KCTD12-CDK1 interaction is necessary for CDK1 activation, we screened an FDA-approved drug library consisting of 616 compounds and identified that adefovir dipivoxil (AD), a nucleoside analog for treatment of HBV infections, disrupts the CDK1-KCTD12 interaction and induces G2 phase arrest in the cell cycle.	adefovir dipivoxil	154-172	cyclin dependent kinase 1	Homo sapiens	48-52
30872078-4	2019	As the KCTD12-CDK1 interaction is necessary for CDK1 activation, we screened an FDA-approved drug library consisting of 616 compounds and identified that adefovir dipivoxil (AD), a nucleoside analog for treatment of HBV infections, disrupts the CDK1-KCTD12 interaction and induces G2 phase arrest in the cell cycle.	adefovir dipivoxil	174-176	cyclin dependent kinase 1	Homo sapiens	14-18
30872078-4	2019	As the KCTD12-CDK1 interaction is necessary for CDK1 activation, we screened an FDA-approved drug library consisting of 616 compounds and identified that adefovir dipivoxil (AD), a nucleoside analog for treatment of HBV infections, disrupts the CDK1-KCTD12 interaction and induces G2 phase arrest in the cell cycle.	adefovir dipivoxil	174-176	cyclin dependent kinase 1	Homo sapiens	48-52
30872078-4	2019	As the KCTD12-CDK1 interaction is necessary for CDK1 activation, we screened an FDA-approved drug library consisting of 616 compounds and identified that adefovir dipivoxil (AD), a nucleoside analog for treatment of HBV infections, disrupts the CDK1-KCTD12 interaction and induces G2 phase arrest in the cell cycle.	adefovir dipivoxil	174-176	cyclin dependent kinase 1	Homo sapiens	48-52
30872078-4	2019	As the KCTD12-CDK1 interaction is necessary for CDK1 activation, we screened an FDA-approved drug library consisting of 616 compounds and identified that adefovir dipivoxil (AD), a nucleoside analog for treatment of HBV infections, disrupts the CDK1-KCTD12 interaction and induces G2 phase arrest in the cell cycle.	Nucleosides	181-191	cyclin dependent kinase 1	Homo sapiens	14-18
30872078-7	2019	This study reveals that CDK1 activation induces vemurafenib resistance and that AD is a promising therapeutic strategy for colon cancer both as a single agent and in combination with vemurafenib.	Vemurafenib	48-59	cyclin dependent kinase 1	Homo sapiens	24-28
31035650-7	2019	p85alpha-phosphatase and tensin homolog deleted from chromosome 10 (PTEN) complex-mediated inactivation of Akt was required for citrate-induced G2/M phase cell cycle arrest because PTEN short hairpin RNA or a PTEN inhibitor (SF1670) blocked the suppression of Akt Ser 473 phosphorylation and the induction of cyclin B1-p-CDK1 (Thr 161) complexes and G2/M phase arrest by citrate.	Citric Acid	128-135	cyclin dependent kinase 1	Homo sapiens	321-325
31048671-14	2019	Among these molecules, trichostatin A had the greatest ability in combining with CDK1.	trichostatin A	23-37	cyclin dependent kinase 1	Homo sapiens	81-85
31173293-0	2019	Long noncoding RNA OR3A4 promotes cisplatin resistance of non-small cell lung cancer by upregulating CDK1.	Cisplatin	34-43	cyclin dependent kinase 1	Homo sapiens	101-105
31173293-9	2019	CONCLUSIONS: The present work suggests that OR3A4 participates in regulating cell cycle, cell apoptosis of NSCLC cells and the resistance to cisplatin via upregulating CDK1, indicating that OR3A4 could be identified as a potential therapeutic target for NSCLC patients.	Cisplatin	141-150	cyclin dependent kinase 1	Homo sapiens	168-172
29251999-5	2019	Among them, compound 15beta-hydroxy-20(R)-panaxatriol (4) exhibited selective inhibitory effects on human leukaemic progenitor cells K562/ADR through arresting cell cycle, which was associated with obvious decrease of cyclin B1, cyclin D1 and cyclin-dependent kinase (CDK) 1/2/4/6 protein expression.	15beta-hydroxy-20(r)-panaxatriol	21-53	cyclin dependent kinase 1	Homo sapiens	243-280
31035650-4	2019	A coimmunoprecipitation study demonstrated that citrate-induced cell cycle arrest in the G2/M phase was associated with stabilizing the formation of cyclin B1-phospho (p)-cyclin-dependent kinase 1 (CDK1) (Thr 161) complexes.	Citric Acid	48-55	cyclin dependent kinase 1	Homo sapiens	171-196
31035650-4	2019	A coimmunoprecipitation study demonstrated that citrate-induced cell cycle arrest in the G2/M phase was associated with stabilizing the formation of cyclin B1-phospho (p)-cyclin-dependent kinase 1 (CDK1) (Thr 161) complexes.	Citric Acid	48-55	cyclin dependent kinase 1	Homo sapiens	198-202
31097686-0	2019	Cyclin-dependent kinase 1-mediated phosphorylation of SET at serine 7 is essential for its oncogenic activity.	Serine	61-67	cyclin dependent kinase 1	Homo sapiens	0-25
31097686-4	2019	We found that the mitotic kinase cyclin-dependent kinase 1 (CDK1) phosphorylates SET isoform 1 in vitro and in vivo at serine 7 during antitubulin drug-induced mitotic arrest and normal mitosis.	Serine	119-125	cyclin dependent kinase 1	Homo sapiens	33-58
31097686-4	2019	We found that the mitotic kinase cyclin-dependent kinase 1 (CDK1) phosphorylates SET isoform 1 in vitro and in vivo at serine 7 during antitubulin drug-induced mitotic arrest and normal mitosis.	Serine	119-125	cyclin dependent kinase 1	Homo sapiens	60-64
30889542-6	2019	Andrographolide treatment thereby switch on subG1 phase arrest by modulating cellular check points (cyclin A, B, cyclin dependent kinase-1) cueing to the apoptosis event.	andrographolide	0-15	cyclin dependent kinase 1	Homo sapiens	100-138
31035650-4	2019	A coimmunoprecipitation study demonstrated that citrate-induced cell cycle arrest in the G2/M phase was associated with stabilizing the formation of cyclin B1-phospho (p)-cyclin-dependent kinase 1 (CDK1) (Thr 161) complexes.	Threonine	205-208	cyclin dependent kinase 1	Homo sapiens	171-196
31035650-8	2019	In conclusion, citrate induces G2/M phase arrest in PSC cells by inducing the formation of p85alpha-PTEN complexes to attenuate Akt-mediated signaling, thereby causing the formation of cyclin B1-p-CDK1 (Thr 161) complexes.	Citric Acid	15-22	cyclin dependent kinase 1	Homo sapiens	197-201
31143512-9	2019	Exposure of healthy donor cDC2 to Dex or GBM cell lysate resulted in a similar low IL-12:IL-10 ratio.	Dexamethasone	34-37	cyclin dependent kinase 1	Homo sapiens	26-30
31105693-7	2019	Moreover, poly(I:C) up regulated the expression of costimulatory molecules in both cDC1 and cDC2 DCs subsets.	Poly I-C	10-19	cyclin dependent kinase 1	Homo sapiens	92-96
30816542-5	2019	Further studies demonstrated that bufotalin significantly upregulated the protein levels of ATM serine/threonine kinase and Chk2, downregulated CDC25C protein expression, and subsequently inhibited CDK1 expression, leading to cell cycle arrest at the G2/M phase of the A375 cells.	bufotalin	34-43	cyclin dependent kinase 1	Homo sapiens	198-202
30962488-6	2019	Mechanistically, eribulin plus MK-2206 induced G1 or G2/M arrest by down-regulating cyclin-dependent kinases, cyclins and cdc2, followed by caspase-dependent apoptosis in STS cells.	MK 2206	31-38	cyclin dependent kinase 1	Homo sapiens	122-126
30723163-7	2019	We also noted that the EML3-mediated recruitment is controlled by cyclin-dependent kinase 1 (CDK1), which phosphorylated EML3 at Thr-881 and promoted its binding to Augmin/gamma-TuRC.	Threonine	129-132	cyclin dependent kinase 1	Homo sapiens	66-91
30723163-7	2019	We also noted that the EML3-mediated recruitment is controlled by cyclin-dependent kinase 1 (CDK1), which phosphorylated EML3 at Thr-881 and promoted its binding to Augmin/gamma-TuRC.	Threonine	129-132	cyclin dependent kinase 1	Homo sapiens	93-97
31001122-9	2019	Further, a transcriptional analysis (RNA-seq) revealed that THTMP targeted the p53 signaling pathway specific genes causing DNA damage and cell cycle arrest at G1/S phase explained by the decrease of cyclin-dependent kinase 1, cyclin A2, cyclin E1 and E2 in glioma cells.	thtmp	60-65	cyclin dependent kinase 1	Homo sapiens	200-225
30931929-0	2019	Iron-dependent CDK1 activity promotes lung carcinogenesis via activation of the GP130/STAT3 signaling pathway.	Iron	0-4	cyclin dependent kinase 1	Homo sapiens	15-19
30931929-2	2019	Iron directly binds CDK1, which is upregulated in several cancers, thereby promoting JAK1 phosphorylation and activation of STAT3 signaling to promote colorectal carcinogenesis.	Iron	0-4	cyclin dependent kinase 1	Homo sapiens	20-24
30931929-4	2019	We found that iron-dependent CDK1 activity upregulated IL-6 receptor subunit GP130 post-transcriptionally via phosphorylation of 4E-BP1, which is critical for activation of JAK/STAT3 signaling.	Iron	14-18	cyclin dependent kinase 1	Homo sapiens	29-33
30931929-5	2019	CDK1 and STAT3 are essential for iron-mediated colony formation in lung cancer cell lines.	Iron	33-37	cyclin dependent kinase 1	Homo sapiens	0-4
30765437-0	2019	CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation.	Serine	37-43	cyclin dependent kinase 1	Homo sapiens	0-4
30838018-10	2019	CDK1 was proved to be the functional target of miR-378a-5p in VSMCs.	vsmcs	62-67	cyclin dependent kinase 1	Homo sapiens	0-4
30826569-9	2019	The antitumor effects of nor-wogonin can be attributed to cell cycle arrest via reduction of the expression of cyclin D1, cyclin B1, and CDK1.	norwogonin	25-36	cyclin dependent kinase 1	Homo sapiens	137-141
30917530-4	2019	Using in vitro kinase assays, we demonstrated that 2,4,6-THBA dose-dependently inhibited CDKs 1, 2 and 4 and in silico studies identified key amino acids involved in these interactions.	2,4,6-trihydroxybenzoic acid	51-61	cyclin dependent kinase 1	Homo sapiens	89-104
30565332-4	2019	Our findings concluded that BCH showed good inhibition on the HCC proliferation and colony formation, which attributed to cell cycle arrest by BCH at G1 phase through impairing the expression of cyclinD1, cyclinE, and cdc2 and downregulated the phosphorylation of Akt, mTOR, and ERK.	bis(cyclohexylammonium)sulfate	28-31	cyclin dependent kinase 1	Homo sapiens	218-222
30481564-7	2019	Cyclin B1/CDK1-mediated mitochondrial bioenergetics is applied as an example to show how mitochondria could timely sense the cellular fuel demand and then coordinate ATP output.	Adenosine Triphosphate	166-169	cyclin dependent kinase 1	Homo sapiens	10-14
30301655-8	2019	Although agreement among definitions was high (kappa = 0.82-0.93), definitions including ertapenem resistance led to higher CRE prevalence (VA1 = 1.7% and CDC2 = 1.9% vs VA2 = 1.4% and CDC1 = 1.5%).	Ertapenem	89-98	cyclin dependent kinase 1	Homo sapiens	155-159
30754676-5	2019	In C/EBPbeta-knockdown cells, a prolonged increase in phosphorylation of cyclin dependent kinase 1 at tyrosine 15 (Y15-pCDK1) was displayed with simultaneously increased Wee1 and decreased Cdc25B expression.	Tyrosine	102-110	cyclin dependent kinase 1	Homo sapiens	73-98
30335624-4	2019	Flow cytometric analyses indicated that PB-induced G2/M arrest through down-regulation of cyclin B1 and cell division control protein cyclin-dependent kinase 1, and up-regulation of p21.	physalin B	40-42	cyclin dependent kinase 1	Homo sapiens	134-159
30942613-6	2019	Significant increases in calcium and integrin-binding protein 1 (CIB1) and reduction of cyclin-dependent kinase 1 b (CDK1) were also found after 2 Hz TEAS treatment.	Silicon triethanolamine	150-154	cyclin dependent kinase 1	Homo sapiens	88-115
30942613-6	2019	Significant increases in calcium and integrin-binding protein 1 (CIB1) and reduction of cyclin-dependent kinase 1 b (CDK1) were also found after 2 Hz TEAS treatment.	Silicon triethanolamine	150-154	cyclin dependent kinase 1	Homo sapiens	117-121
30472117-4	2019	We have used biophysical measurements and X-ray crystallography to investigate the ATP-competitive inhibitor binding properties of cyclin-free and cyclin-bound CDK1 and CDK2.	Adenosine Triphosphate	83-86	cyclin dependent kinase 1	Homo sapiens	160-164
30453847-2	2019	Cyclin D kinase (CDK) 1 could influence the nuclear export and activity of FoxO1 through phosphorylation of serine (S)249.	Serine	108-114	cyclin dependent kinase 1	Homo sapiens	0-23
30745871-5	2019	CUMA also suppressed the activity of CDK1/cyclin B1 complex and led to G2/M-phase arrest of A375-R cells.	cumingianoside A	0-4	cyclin dependent kinase 1	Homo sapiens	37-41
30398122-7	2019	Furthermore, western blot analysis showed that DMQ arrested cells at G2/M checkpoint by down-regulation of cyclin B1, cdc2 and cdc25c and up-regulation of p21, and induced cell apoptosis via affecting the ratio of Bax/Bcl-2, causing loss of the mitochondrial membrane potential and enhancing the expression of cleaved caspase-9 (C-caspase-9) and cleaved caspase-3 (C-caspase-3).	3,3'-di-O-methylquercetin	47-50	cyclin dependent kinase 1	Homo sapiens	118-122
30697079-15	2019	CDK1 was also an RFS-related biomarker, with its high expression predicting poor RFS.	Br-paroxetine	17-20	cyclin dependent kinase 1	Homo sapiens	0-4
30606243-10	2019	Western blot showed that epirubicin upregulated Gadd45b protein expression and downregulated CyclinB1 and CDC2 protein expression, while MB-MSCs downregulated Gadd45b protein expression and upregulated CyclinB1 and CDC2 protein expression.	Epirubicin	25-35	cyclin dependent kinase 1	Homo sapiens	106-110
30745798-7	2019	Furthermore, ETCH induced G2 phase cell cycle arrest by transcriptionally regulating of genes involved in G2 / M transition including p21 (CDKN1A), cyclin B1 (CCNB1), and CDK1; CDKN1A mRNA levels were upregulated in response to ETCH, whereas CCNB1 and CDK1 were downregulated.	etch	13-17	cyclin dependent kinase 1	Homo sapiens	171-175
30538118-3	2019	In addition to replication stress response proteins, GMGs contain factors involved in RNA metabolism as well as CDK1.	gmgs	53-57	cyclin dependent kinase 1	Homo sapiens	112-116
30745798-7	2019	Furthermore, ETCH induced G2 phase cell cycle arrest by transcriptionally regulating of genes involved in G2 / M transition including p21 (CDKN1A), cyclin B1 (CCNB1), and CDK1; CDKN1A mRNA levels were upregulated in response to ETCH, whereas CCNB1 and CDK1 were downregulated.	etch	13-17	cyclin dependent kinase 1	Homo sapiens	252-256
30508677-15	2019	These inhibitors bind in the cleft between the N-terminal and C-terminal lobes of the CDKs and they inhibit ATP binding.	Adenosine Triphosphate	108-111	cyclin dependent kinase 1	Homo sapiens	86-90
30358420-4	2019	In the, herein, reported study, we checked the effects of 1,25-dihydroxyvitamin D3 concentrations on the expression level of the vitamin D receptor (VDR) and cell cycle-related proteins CDKN1A (p21) and CDK1 in pancreatic cells and Panc-1 pancreatic cancer (PC) cells.	Calcitriol	58-82	cyclin dependent kinase 1	Homo sapiens	203-207
30358420-5	2019	We found that VDR, CDKN1A, and CDK1 were upregulated by an increase in 1,25-dihydroxyvitamin D3 concentration in normal pancreatic cells but not in the advanced cancer cell line Panc-1 from poorly differentiated metastatic PC cells.	Calcitriol	71-95	cyclin dependent kinase 1	Homo sapiens	31-35
30358420-7	2019	By increasing the level of cell cycle inhibitory and promoting proteins p21 and CDK1, vitamin D theoretically has both preventive and promoting effects on pancreatic cell division.	Vitamin D	86-95	cyclin dependent kinase 1	Homo sapiens	80-84
30029111-10	2018	Simultaneously, ROS induced persistent DNA-damage (Comet-assay) that stimulated G2/M arrest for p53-mediated damage-repair, aided by checkpoint-promoter (Chk1) activation and mitotic-inducers (i.e. Cdc-25, Cdk1, cyclinB1) inhibition.	ros	16-19	cyclin dependent kinase 1	Homo sapiens	206-210
30273737-4	2019	In the first experiment, matured oocytes were exposed to ionomycin (Ion) for 5 min, and then treated with a specific CDK1 inhibitor (RO-3306) and/or PKC activator (OAG) for different time intervals.	RO 3306	133-140	cyclin dependent kinase 1	Homo sapiens	117-121
30273737-7	2019	Next, we observed that treatment with PKCa + CDK1i for 4 h after TPEN for 15 min decreased embryo development compared to TPEN alone.	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	65-69	cyclin dependent kinase 1	Homo sapiens	45-49
30273737-7	2019	Next, we observed that treatment with PKCa + CDK1i for 4 h after TPEN for 15 min decreased embryo development compared to TPEN alone.	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	122-126	cyclin dependent kinase 1	Homo sapiens	45-49
30591797-5	2018	Histone H2AX phosphorylation and expression of Myt1, cyclin A2, cyclin B1 and p53 were increased in HCT8 and HT29 cells on treatment with matrine for 48 h. Matrine treatment also increased the phosphorylation of cdc2 significantly compared to control cells at 48 h (P &lt; 0.05).	matrine	138-145	cyclin dependent kinase 1	Homo sapiens	212-216
30317550-4	2018	Phosphorylation of HPC2 at threonine 495 is required for recruiting Ring1 and Rb family proteins to form the polycomb repressive complex (PRC), and PRC is required for arsenate-induced downregulation of CDC2 expression.	Threonine	27-36	cyclin dependent kinase 1	Homo sapiens	203-207
30317550-4	2018	Phosphorylation of HPC2 at threonine 495 is required for recruiting Ring1 and Rb family proteins to form the polycomb repressive complex (PRC), and PRC is required for arsenate-induced downregulation of CDC2 expression.	arsenic acid	168-176	cyclin dependent kinase 1	Homo sapiens	203-207
30473536-5	2018	Our observations are consistent with a model in which alpha-pinene inhibits miR221 expression, which leads to G2/M-phase arrest and activation of CDKN1B/p27-CDK1 and ATM-p53-Chk2 pathways that suppress human hepatoma tumor progression.	alpha-pinene	54-66	cyclin dependent kinase 1	Homo sapiens	157-161
30449668-6	2018	By measuring mitotic entry and exit thresholds using ATP-analog-sensitive Cdk1 mutants, we find evidence that the mitotic switch displays hysteresis and bistability, responding differentially to Cdk1 inhibition in the mitotic and interphase states.	Adenosine Triphosphate	53-56	cyclin dependent kinase 1	Homo sapiens	74-78
30449668-6	2018	By measuring mitotic entry and exit thresholds using ATP-analog-sensitive Cdk1 mutants, we find evidence that the mitotic switch displays hysteresis and bistability, responding differentially to Cdk1 inhibition in the mitotic and interphase states.	Adenosine Triphosphate	53-56	cyclin dependent kinase 1	Homo sapiens	195-199
30297536-7	2018	Furthermore, GSEA analysis of CDK1hi tumor cells identified a pathway signature common in all three cancer types, including E2F, G2M, MYC, and spermatogenesis, confirming a stem-like nature of CDK1hi tumor cells.	gsea	13-17	cyclin dependent kinase 1	Homo sapiens	30-34
30202980-7	2018	CDK1/Aurora A-mediated CtIP phosphorylation at serine 327 triggers CtIP binding to the PLK1 polo-box domain, which in turn facilitates PLK1 to phosphorylate CtIP mainly at serine 723.	Serine	47-53	cyclin dependent kinase 1	Homo sapiens	0-4
30202980-7	2018	CDK1/Aurora A-mediated CtIP phosphorylation at serine 327 triggers CtIP binding to the PLK1 polo-box domain, which in turn facilitates PLK1 to phosphorylate CtIP mainly at serine 723.	Serine	172-178	cyclin dependent kinase 1	Homo sapiens	0-4
30107342-5	2018	Cell cycle analyses showed that AMANTADIG and its synergistic combination induced G2/M arrest of DU145 and PC-3 cells by modulating Cyclin B1, CDK1, p21 and, mainly, survivin expression, a promising target in cancer therapy.	3-(2-(1-amantadine)-1-one-ethylamine)digitoxigenin	32-41	cyclin dependent kinase 1	Homo sapiens	143-147
30220558-8	2018	Phosphoproteomics on the fractions reveals that phosphorylation of serine 38 in RPL12/uL11, a known mitotic CDK1 substrate, is strongly depleted in polysomes.	Serine	67-73	cyclin dependent kinase 1	Homo sapiens	108-112
30384473-8	2018	We found that Evo significantly induced cell cycle arrest at the G2/M phase, upregulated P53 and Bcl-2 associated X proteins (Bax) proteins, and downregulated B-cell lymphoma-2 (Bcl-2), cyclinB1, and cdc2 proteins in HCC cells.	evodiamine	14-17	cyclin dependent kinase 1	Homo sapiens	200-204
30145177-0	2018	Diosbulbin B induced G2/M cell cycle arrest in hepatocytes by miRNA-186-3p and miRNA-378a-5p-mediated the decreased expression of CDK1.	diosbulbin B	0-12	cyclin dependent kinase 1	Homo sapiens	130-134
30145177-12	2018	Taken together, our results showed that DB induced hepatotoxicity by inducing G2/M cell cycle arrest in hepatocytes via miR-186-3p or miR-378a-5p-mediated the reduced CDK1 expression.	diosbulbin B	40-42	cyclin dependent kinase 1	Homo sapiens	167-171
30105797-0	2018	miR-129 targets CDK1 and iASPP to modulate Burkitt lymphoma cell proliferation in a TAp63-dependent manner.	mir-129	0-7	cyclin dependent kinase 1	Homo sapiens	16-20
30105797-9	2018	We revealed that miR-129 acted as a tumor suppressor by inhibiting cancer cell proliferation and inhibiting CDK1 and iASPP via direct binding.	mir-129	17-24	cyclin dependent kinase 1	Homo sapiens	108-112
30105797-11	2018	Taken together, miR-129 could targetedly inhibit the expression of CDK1 and iASPP.	mir-129	16-23	cyclin dependent kinase 1	Homo sapiens	67-71
30105797-12	2018	CDK1 knockdown inhibits iASPP S84/S113 phosphorylation, thus blocking iASPP nucleus localization, suppressing the inhibitory effect of iASPP on p53 and TAp63, and restoring TAp63-induced proliferation inhibition in Burkitt lymphoma cells.	tap63	152-157	cyclin dependent kinase 1	Homo sapiens	0-4
30135207-0	2018	The tyrosine kinase v-Src causes mitotic slippage by phosphorylating an inhibitory tyrosine residue of Cdk1.	Tyrosine	4-12	cyclin dependent kinase 1	Homo sapiens	103-107
30135207-5	2018	Proteomic analysis and in vitro kinase assay revealed that v-Src phosphorylates cyclin-dependent kinase 1 (Cdk1) at Tyr-15.	Tyrosine	116-119	cyclin dependent kinase 1	Homo sapiens	80-105
30135207-5	2018	Proteomic analysis and in vitro kinase assay revealed that v-Src phosphorylates cyclin-dependent kinase 1 (Cdk1) at Tyr-15.	Tyrosine	116-119	cyclin dependent kinase 1	Homo sapiens	107-111
30135207-8	2018	These results suggest that v-Src causes mitotic slippage by attenuating Cdk1 kinase activity via direct phosphorylation of Cdk1 at Tyr-15.	Tyrosine	131-134	cyclin dependent kinase 1	Homo sapiens	72-76
30135207-8	2018	These results suggest that v-Src causes mitotic slippage by attenuating Cdk1 kinase activity via direct phosphorylation of Cdk1 at Tyr-15.	Tyrosine	131-134	cyclin dependent kinase 1	Homo sapiens	123-127
30066853-7	2018	Cerdulatinib induced cell cycle arrest in the G2/M phase, which was associated with a decreased cyclin-dependent kinase 1 and cyclin B1, and an increased p21 and p27 expression.	4-(cyclopropylamino)-2-((4-(4-(ethylsulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide	0-12	cyclin dependent kinase 1	Homo sapiens	96-121
30085332-0	2018	Radiosensitization by irinotecan is attributed to G2/M phase arrest, followed by enhanced apoptosis, probably through the ATM/Chk/Cdc25C/Cdc2 pathway in p53-mutant colorectal cancer cells.	Irinotecan	22-32	cyclin dependent kinase 1	Homo sapiens	130-134
30009775-4	2018	In this study, the results illustrated that DMC induced Reactive oxygen species (ROS) leads to reduced expression of CDC25C, Cyclin B1 and CDK1 (Thr161) triggers G2/M cell cycle arrest in U87 MG glioma cells.	methyl carbonate	44-47	cyclin dependent kinase 1	Homo sapiens	139-143
30085332-11	2018	In addition, the expression of Ser216p-Cdc25C was also increased in the combined group, indicating that irinotecan likely radiosensitized the p53-mutant HT29 and SW620 cells through the ATM/Chk/Cdc25C/Cdc2 pathway.	ser216p	31-38	cyclin dependent kinase 1	Homo sapiens	39-43
30085332-11	2018	In addition, the expression of Ser216p-Cdc25C was also increased in the combined group, indicating that irinotecan likely radiosensitized the p53-mutant HT29 and SW620 cells through the ATM/Chk/Cdc25C/Cdc2 pathway.	Irinotecan	104-114	cyclin dependent kinase 1	Homo sapiens	39-43
30066939-4	2018	Lycorine inhibited the proliferation of HepG2 cells in a dose-dependent manner by inducing cell cycle arrest at the G2/M phase, via downregulation of cyclin A, cyclin B1 and cyclin dependent kinase 1.	lycorine	0-8	cyclin dependent kinase 1	Homo sapiens	174-199
30009775-4	2018	In this study, the results illustrated that DMC induced Reactive oxygen species (ROS) leads to reduced expression of CDC25C, Cyclin B1 and CDK1 (Thr161) triggers G2/M cell cycle arrest in U87 MG glioma cells.	Reactive Oxygen Species	56-79	cyclin dependent kinase 1	Homo sapiens	139-143
30009775-4	2018	In this study, the results illustrated that DMC induced Reactive oxygen species (ROS) leads to reduced expression of CDC25C, Cyclin B1 and CDK1 (Thr161) triggers G2/M cell cycle arrest in U87 MG glioma cells.	Reactive Oxygen Species	81-84	cyclin dependent kinase 1	Homo sapiens	139-143
30009775-7	2018	To explore the possibility of direct involvement of DMC in the dissociation of CDK1/Cyclin B1 complex, the molecular docking and MD simulation studies were carried.	methyl carbonate	52-55	cyclin dependent kinase 1	Homo sapiens	79-83
30009775-8	2018	The results showed that DMC nicely fitted into the binding site of CDK1 and Cyclin B1 with minimum binding energy (DeltaG) of -9.46 kcal/mol (Ki = 0.11 muM) and - 9.90 kcal/mol (Ki = 0.05 muM) respectively.	methyl carbonate	24-27	cyclin dependent kinase 1	Homo sapiens	67-71
30128000-3	2018	In the present study, it was demonstrated that bufalin inhibited cell proliferation, blocked the cell cycle in the G2/M phase, and reduced the metastasis of human RCC ACHN cells via the upregulation of p21waf/cip1 and E-cadherin and the downregulation of cyclin dependent kinase 1, cyclin B1, N-cadherin, and hypoxia-inducible factor-1alpha (HIF-1alpha).	bufalin	47-54	cyclin dependent kinase 1	Homo sapiens	255-280
30248086-8	2018	In addition, cantharidin-induced apoptosis was accompanied by increased expression of Bax and PARP and decreased expression of Bcl-2, p-Akt, and p-Cdc2.	Cantharidin	13-24	cyclin dependent kinase 1	Homo sapiens	147-151
29570858-4	2018	Perturbation of processes associated with quiescence and catabolism, including AMP-activated protein kinase signaling, fatty acid oxidation, or mitochondrial clearance increased development of cDC2 cells at the expense of cDC1 cells.	Fatty Acids	119-129	cyclin dependent kinase 1	Homo sapiens	193-197
30127912-4	2018	In addition, DPT treatment resulted in G2/M phase cell cycle arrest associated with the downregulation of Cyclin B and cyclin dependent kinase 1 and caused an increase in apoptosis that was confirmed by characteristic morphological changes.	deoxypodophyllotoxin	13-16	cyclin dependent kinase 1	Homo sapiens	119-144
30116377-5	2018	In-depth study of its mechanism of action revealed that curcumin induced cell cycle arrest at the G2/M phase and decreased the expression of the CDC25 and CDC2 proteins, while increasing the expression of P21.	Curcumin	56-64	cyclin dependent kinase 1	Homo sapiens	145-149
30135308-4	2018	Using human MTC cells that are either sensitive or resistant to vandetanib, we demonstrate that palbociclib (CDK4/6 inhibitor) is not cytotoxic to MTC cells but that they are highly sensitive to dinaciclib (CDK1/2/5/9 inhibitor) accompanied by reduced CDK9 and RET protein and mRNA levels.	palbociclib	96-107	cyclin dependent kinase 1	Homo sapiens	207-217
30250647-5	2018	Because flavopiridol is a potent cyclin-dependent kinase (CDK) inhibitor, we found significantly higher CDK1 and CDK2 mRNA expression in three independent cohorts human ACC (p&lt;0.01) and CDK1 protein by immunohistochemistry (p&lt;0.01) in human ACC samples.	alvocidib	8-20	cyclin dependent kinase 1	Homo sapiens	104-108
30250647-5	2018	Because flavopiridol is a potent cyclin-dependent kinase (CDK) inhibitor, we found significantly higher CDK1 and CDK2 mRNA expression in three independent cohorts human ACC (p&lt;0.01) and CDK1 protein by immunohistochemistry (p&lt;0.01) in human ACC samples.	alvocidib	8-20	cyclin dependent kinase 1	Homo sapiens	189-193
30116377-7	2018	In conclusion, curcumin inhibited the proliferation of breast cancer cells and induced G2/M phase cell cycle arrest and apoptosis, which may be associated with the decrease of CDC25 and CDC2 and increase of P21 protein levels, as well as inhibition of the phosphorylation of Akt/mTOR and induction of the mitochondrial apoptotic pathway.	Curcumin	15-23	cyclin dependent kinase 1	Homo sapiens	176-180
30067982-6	2018	Mechanistically, we found that MIG6 depletion results in reduced phosphorylation of CDK1 on the inhibitory WEE1-targeted tyrosine-15 residue.	Tyrosine	121-129	cyclin dependent kinase 1	Homo sapiens	84-88
30008466-10	2018	Ludartin exerted its anti-proliferative effects on Saos-2 cells via induction of apoptosis and cell cycle arrest at the G2/M checkpoint, associated with reduced expression of Cdc25c (Ser216), Cdc25c, pCdc2 (Tyr15), and Cdc2 and increased expression of p21WAF1.	ludartin	0-8	cyclin dependent kinase 1	Homo sapiens	175-179
30100745-15	2018	Analysis of cell cycles indicated that euphornin induced cell cycle arrest by increasing the level of the phospho-CDK1 (Tyr15) protein.	euphornin	39-48	cyclin dependent kinase 1	Homo sapiens	114-118
30011295-6	2018	Pre-treatment with the antioxidant, N-acetylcysteine, prevented the actions of arecoline on cell viability, G2/M growth arrest, reactive oxygen species (ROS) production, and the levels of CDK1, p21, p27, p53, cyclin B1, and phospho-AMPK proteins.	Acetylcysteine	36-52	cyclin dependent kinase 1	Homo sapiens	188-192
30011295-6	2018	Pre-treatment with the antioxidant, N-acetylcysteine, prevented the actions of arecoline on cell viability, G2/M growth arrest, reactive oxygen species (ROS) production, and the levels of CDK1, p21, p27, p53, cyclin B1, and phospho-AMPK proteins.	Arecoline	79-88	cyclin dependent kinase 1	Homo sapiens	188-192
29954437-10	2018	Given the DNA damage checkpoint as a primary target of WEE1 inhibition, our data also demonstrate that AZD1775 abrogated olaparib-activated DNA damage checkpoint through CDC2 de-phosphorylation, followed by mitotic progression with unrepaired DNA damage (marked by increased pHH3-stained and gammaH2AX-stained cells, respectively).	adavosertib	103-110	cyclin dependent kinase 1	Homo sapiens	170-174
30011295-3	2018	Arecoline arrested preadipocyte growth in the G2/M phase of the cell cycle; decreased the total levels of cyclin-dependent kinase 1 (CDK1), p21, and p27 proteins; increased p53 and cyclin B1 protein levels; and had no effect on CDK2 protein levels.	Arecoline	0-9	cyclin dependent kinase 1	Homo sapiens	106-131
30011295-3	2018	Arecoline arrested preadipocyte growth in the G2/M phase of the cell cycle; decreased the total levels of cyclin-dependent kinase 1 (CDK1), p21, and p27 proteins; increased p53 and cyclin B1 protein levels; and had no effect on CDK2 protein levels.	Arecoline	0-9	cyclin dependent kinase 1	Homo sapiens	133-137
30011295-4	2018	These results suggested that arecoline selectively affected a particular CDK subfamily.	Arecoline	29-38	cyclin dependent kinase 1	Homo sapiens	73-76
30038716-5	2018	We show that O6-benzylguanine (BG), an MGMT inhibitor decreases CDC2, CDC20, TOP2A, AURKB, KIF20A, cyclin B2, A2, D1, ERalpha and survivin and induces c-PARP and p21 and sensitizes ER positive breast cancer to temozolomide (TMZ).	O(6)-benzylguanine	13-29	cyclin dependent kinase 1	Homo sapiens	64-68
30038716-5	2018	We show that O6-benzylguanine (BG), an MGMT inhibitor decreases CDC2, CDC20, TOP2A, AURKB, KIF20A, cyclin B2, A2, D1, ERalpha and survivin and induces c-PARP and p21 and sensitizes ER positive breast cancer to temozolomide (TMZ).	O(6)-benzylguanine	31-33	cyclin dependent kinase 1	Homo sapiens	64-68
29688264-4	2018	DCZ3301-induced G2/M cell cycle arrest, associated with downregulation of CDK1, cyclin B1, and cdc25C.	DCZ3301	0-7	cyclin dependent kinase 1	Homo sapiens	74-78
29954437-10	2018	Given the DNA damage checkpoint as a primary target of WEE1 inhibition, our data also demonstrate that AZD1775 abrogated olaparib-activated DNA damage checkpoint through CDC2 de-phosphorylation, followed by mitotic progression with unrepaired DNA damage (marked by increased pHH3-stained and gammaH2AX-stained cells, respectively).	olaparib	121-129	cyclin dependent kinase 1	Homo sapiens	170-174
30083256-0	2018	Blocking CDK1/PDK1/beta-Catenin signaling by CDK1 inhibitor RO3306 increased the efficacy of sorafenib treatment by targeting cancer stem cells in a preclinical model of hepatocellular carcinoma.	RO 3306	60-66	cyclin dependent kinase 1	Homo sapiens	9-13
30083256-0	2018	Blocking CDK1/PDK1/beta-Catenin signaling by CDK1 inhibitor RO3306 increased the efficacy of sorafenib treatment by targeting cancer stem cells in a preclinical model of hepatocellular carcinoma.	RO 3306	60-66	cyclin dependent kinase 1	Homo sapiens	45-49
30083256-0	2018	Blocking CDK1/PDK1/beta-Catenin signaling by CDK1 inhibitor RO3306 increased the efficacy of sorafenib treatment by targeting cancer stem cells in a preclinical model of hepatocellular carcinoma.	Sorafenib	93-102	cyclin dependent kinase 1	Homo sapiens	9-13
30083256-0	2018	Blocking CDK1/PDK1/beta-Catenin signaling by CDK1 inhibitor RO3306 increased the efficacy of sorafenib treatment by targeting cancer stem cells in a preclinical model of hepatocellular carcinoma.	Sorafenib	93-102	cyclin dependent kinase 1	Homo sapiens	45-49
30083256-7	2018	CDK1 inhibitor RO3306 in combination with sorafenib treatment significantly decreased tumor growth in PDX tumor models.	RO 3306	15-21	cyclin dependent kinase 1	Homo sapiens	0-4
30083256-12	2018	Mechanistic and functional studies silencing CDK1 with shRNA and RO3306 combined with sorafenib abolished oncogenic function via downregulating CDK1, with downstream PDK1 and beta-Catenin inactivation.	RO 3306	65-71	cyclin dependent kinase 1	Homo sapiens	45-49
30083256-12	2018	Mechanistic and functional studies silencing CDK1 with shRNA and RO3306 combined with sorafenib abolished oncogenic function via downregulating CDK1, with downstream PDK1 and beta-Catenin inactivation.	RO 3306	65-71	cyclin dependent kinase 1	Homo sapiens	144-148
30083256-12	2018	Mechanistic and functional studies silencing CDK1 with shRNA and RO3306 combined with sorafenib abolished oncogenic function via downregulating CDK1, with downstream PDK1 and beta-Catenin inactivation.	Sorafenib	86-95	cyclin dependent kinase 1	Homo sapiens	45-49
30083256-12	2018	Mechanistic and functional studies silencing CDK1 with shRNA and RO3306 combined with sorafenib abolished oncogenic function via downregulating CDK1, with downstream PDK1 and beta-Catenin inactivation.	Sorafenib	86-95	cyclin dependent kinase 1	Homo sapiens	144-148
30083256-13	2018	Conclusion: Anti-CDK1 treatment can boost sorafenib antitumor responses in PDX tumor models, providing a rational combined treatment to increase sorafenib efficacy in the clinic.	Sorafenib	42-51	cyclin dependent kinase 1	Homo sapiens	17-21
30083256-13	2018	Conclusion: Anti-CDK1 treatment can boost sorafenib antitumor responses in PDX tumor models, providing a rational combined treatment to increase sorafenib efficacy in the clinic.	Sorafenib	145-154	cyclin dependent kinase 1	Homo sapiens	17-21
29884303-8	2018	Effect of Cyclin Dependent Kinase 1 (CDK1) inhibitor, RO3306, on BeWo cell fusion was studied by microscopy and FACS, and by monitoring the expression of human Chorionic Gonadotropin (hCG) by Western blotting and qPCR.	RO 3306	54-60	cyclin dependent kinase 1	Homo sapiens	10-35
29579711-7	2018	Furthermore, upon exposure to osthole, the expression of Cyclin B1, Cdc2, Bcl-2, PARP1 and Survivin was decreased, while the expression of BAX, cleaved PARP1, cleaved Caspase3 and cleaved Caspase9 was increased.	osthol	30-37	cyclin dependent kinase 1	Homo sapiens	68-72
29576612-2	2018	Phosphorylation of EZH2 augmented EZH2 oncogenic activity in cancer but observations have been limited to threonine 350 (T350) and serine 21 (S21) residues by cyclin-dependent kinase 1 and protein kinase B, respectively.	Threonine	106-115	cyclin dependent kinase 1	Homo sapiens	159-184
29620219-6	2018	In addition, anthricin induced cell cycle arrest at the G2/M phase through suppression of the expression of cell cycle cascade proteins, Cdc2 and Cdc25C.	anthricin	13-22	cyclin dependent kinase 1	Homo sapiens	137-141
29512702-7	2018	The present results suggested that c-Myc regulates cyclin B1- and CDK1-dependent G2/M cell cycle progression by TIP60/MOF-mediated AcH4 in Raji cells.	ach4	131-135	cyclin dependent kinase 1	Homo sapiens	66-70
29884303-8	2018	Effect of Cyclin Dependent Kinase 1 (CDK1) inhibitor, RO3306, on BeWo cell fusion was studied by microscopy and FACS, and by monitoring the expression of human Chorionic Gonadotropin (hCG) by Western blotting and qPCR.	RO 3306	54-60	cyclin dependent kinase 1	Homo sapiens	37-41
29734760-5	2018	In the present study, we demonstrated that kaempferol induced G2/M cell cycle arrest via the Chk2/Cdc25C/Cdc2 pathway and Chk2/p21/Cdc2 pathway in human ovarian cancer A2780/CP70 cells.	kaempferol	43-53	cyclin dependent kinase 1	Homo sapiens	98-102
29950215-3	2018	The expressions of MCL-1, PCNA and CDK1 in K562 cells treated with DADS were detected by Western blot.	amsonic acid	67-71	cyclin dependent kinase 1	Homo sapiens	35-39
29950215-10	2018	Coimmunoprecipitation revealed that MCL-1 bound with PCNA and CDK1, then forming heterodimers, which were downregulated respectively more significantly than that in the control group after treating K562 cells with DADS for 8 h (P&lt;0.05).	amsonic acid	214-218	cyclin dependent kinase 1	Homo sapiens	62-66
29754473-4	2018	We observed that de-polymerization of actin with cytochalasin D (CD) constitutively activated ribosomal S6 kinase (RSK) and induced inhibitory phosphorylation of Cdc2 (Tyr 15) in IMR-90 cells.	Cytochalasin D	49-63	cyclin dependent kinase 1	Homo sapiens	162-166
29754473-4	2018	We observed that de-polymerization of actin with cytochalasin D (CD) constitutively activated ribosomal S6 kinase (RSK) and induced inhibitory phosphorylation of Cdc2 (Tyr 15) in IMR-90 cells.	Tyrosine	168-171	cyclin dependent kinase 1	Homo sapiens	162-166
29754473-7	2018	In DN-RSK overexpressing IMR-90 cells treated with CD, phosphorylation of Cdc25C (Ser 216) was blocked and phosphorylation of Cdc2 (Tyr 15) was decreased, but the phosphorylation of Wee1 (Ser 642) was maintained, demonstrating that RSK directly controls phosphorylation of Cdc25C (Ser 216), but not the activity of Wee1.	Serine	82-85	cyclin dependent kinase 1	Homo sapiens	74-78
29783721-4	2018	AZD1775 is a WEE1 inhibitor that overrides and opens the G2/M checkpoint by preventing WEE1-mediated phosphorylation of cdc2 at tyrosine 15.	adavosertib	0-7	cyclin dependent kinase 1	Homo sapiens	120-124
29783721-4	2018	AZD1775 is a WEE1 inhibitor that overrides and opens the G2/M checkpoint by preventing WEE1-mediated phosphorylation of cdc2 at tyrosine 15.	Tyrosine	128-136	cyclin dependent kinase 1	Homo sapiens	120-124
29734760-5	2018	In the present study, we demonstrated that kaempferol induced G2/M cell cycle arrest via the Chk2/Cdc25C/Cdc2 pathway and Chk2/p21/Cdc2 pathway in human ovarian cancer A2780/CP70 cells.	kaempferol	43-53	cyclin dependent kinase 1	Homo sapiens	105-109
29849796-6	2018	Zerumbone treatment led to the increased expression of p27, cytochrome c, caspase-3 and-9, and Bcl-2-associated X expression, but the decreased expression of cyclin-dependent kinase 1, cyclin B1, B-cell lymphoma-2, focal adhesion kinase, Ras homolog gene family, member A, Rho-associated protein kinase-1, and matrix metalloproteinase-2 and-9 in HepG2 cells.	zerumbone	0-9	cyclin dependent kinase 1	Homo sapiens	158-183
29605721-6	2018	On the other hand, combined treatment with AZD6738 and AZD1775 forces mitotic entry of cells with DNA damages by activating CDK1 activity, inducing severely aberrant mitosis and mitotic catastrophe, ultimately resulting in cell death.	ceralasertib	43-50	cyclin dependent kinase 1	Homo sapiens	124-128
29605721-6	2018	On the other hand, combined treatment with AZD6738 and AZD1775 forces mitotic entry of cells with DNA damages by activating CDK1 activity, inducing severely aberrant mitosis and mitotic catastrophe, ultimately resulting in cell death.	adavosertib	55-62	cyclin dependent kinase 1	Homo sapiens	124-128
29563987-8	2018	It was demonstrated that isorhamnetin inhibited the protein expression of cyclin B1, cell division cycle 25C (Cdc25C) and Cdc2, but enhanced checkpoint kinase 2 (Chk2), Cdc25C and Cdc2 phosphorylation.	3-methylquercetin	25-37	cyclin dependent kinase 1	Homo sapiens	110-114
29651006-8	2018	A new pyrrolo[2,3-alpha]carbazole derivative previously identified as a CDK1 inhibitor, was found to suppress CDK5 activity and eliminate PTN stimulatory effect on cell migration, warranting its further evaluation as a new CDK5 inhibitor.	pyrrolo[2,3-alpha]carbazole	6-33	cyclin dependent kinase 1	Homo sapiens	72-76
29606300-7	2018	All four mutations significantly decreased the amount of WEE2 protein in vitro and in affected individuals" oocytes in vivo, and they all led to abnormal serine phosphorylation of WEE2 and reduced tyrosine 15 phosphorylation of Cdc2 in vitro.	Tyrosine	197-205	cyclin dependent kinase 1	Homo sapiens	228-232
29760710-5	2018	The latter was sensitive to inhibition by the immunosuppressant cyclosporine A, Ca2+ buffer BAPTA-AM, and the CDK1-inhibitor RO3306, indicating the involvement of Ca2+-dependent immune activation and radiation-induced cell cycle arrest.	RO 3306	125-131	cyclin dependent kinase 1	Homo sapiens	110-114
29563987-8	2018	It was demonstrated that isorhamnetin inhibited the protein expression of cyclin B1, cell division cycle 25C (Cdc25C) and Cdc2, but enhanced checkpoint kinase 2 (Chk2), Cdc25C and Cdc2 phosphorylation.	3-methylquercetin	25-37	cyclin dependent kinase 1	Homo sapiens	122-126
29515122-5	2018	BKM120-mediated downregulation of Cyclin A and activation of the CDK1/Cyclin B1 complex facilitates mitotic entry.	NVP-BKM120	0-6	cyclin dependent kinase 1	Homo sapiens	65-69
29590128-5	2018	Western-blot study showed that the expression of cyclin B1 and cdc2 was markedly reduced by osthole.	osthol	92-99	cyclin dependent kinase 1	Homo sapiens	63-67
29590128-6	2018	Moreover, expression of PI3K and pAKT was also significantly suppressed, and the results indicated that the inhibition of pAKT, cyclin B1, and cdc2 levels by osthole was notably enhanced by a PI3K inhibitor.	osthol	158-165	cyclin dependent kinase 1	Homo sapiens	143-147
29233910-4	2018	BRAFV600E colorectal cancer cell lines expressing CDK1 were sensitized to apoptosis upon siRNA knockdown or small-molecule inhibition with RO-3306 (CDK1 inhibitor) or dinaciclib (CDK1, 2, 5, 9 inhibitors).	RO 3306	139-146	cyclin dependent kinase 1	Homo sapiens	50-54
29420299-2	2018	We report here that, during mitosis progression, ARHGAP19 is sequentially phosphorylated by the RhoA-activated kinases ROCK1 and ROCK2 (hereafter ROCK) on serine residue 422, and by CDK1 on threonine residues 404 and 476.	Serine	155-161	cyclin dependent kinase 1	Homo sapiens	182-186
29397071-4	2018	The mechanism study indicated that DN604 inhibited CK2-phosphorylated cdc25C activation to decrease p-cdc25C subcellular localization, leading to the inactivation of cdc2/Cyclin B and G2/M cell cycle arrest and apoptosis in SGC-7901 cancer cells.	dn604	35-40	cyclin dependent kinase 1	Homo sapiens	70-74
29233910-4	2018	BRAFV600E colorectal cancer cell lines expressing CDK1 were sensitized to apoptosis upon siRNA knockdown or small-molecule inhibition with RO-3306 (CDK1 inhibitor) or dinaciclib (CDK1, 2, 5, 9 inhibitors).	RO 3306	139-146	cyclin dependent kinase 1	Homo sapiens	148-152
29233910-4	2018	BRAFV600E colorectal cancer cell lines expressing CDK1 were sensitized to apoptosis upon siRNA knockdown or small-molecule inhibition with RO-3306 (CDK1 inhibitor) or dinaciclib (CDK1, 2, 5, 9 inhibitors).	RO 3306	139-146	cyclin dependent kinase 1	Homo sapiens	148-152
29233910-4	2018	BRAFV600E colorectal cancer cell lines expressing CDK1 were sensitized to apoptosis upon siRNA knockdown or small-molecule inhibition with RO-3306 (CDK1 inhibitor) or dinaciclib (CDK1, 2, 5, 9 inhibitors).	dinaciclib	167-177	cyclin dependent kinase 1	Homo sapiens	50-54
29344638-8	2018	In addition, we found that garcinone C stimulated the expression levels of ATR and 4E-BP1, while efficiently inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, cdc2, CDK7 and Stat3.	garcinone C	27-38	cyclin dependent kinase 1	Homo sapiens	178-182
29277717-10	2018	Collectively, these findings indicate that isoliquiritigenin modulates cyclin B1-CDK1 for G2/M arrest, together with an alteration of cell cycle regulators and apoptotic factors in human prostate cancer cells.	isoliquiritigenin	43-60	cyclin dependent kinase 1	Homo sapiens	81-85
29433585-12	2018	The CDK1/2/9 inhibitor AZD5438 had superior anti-tumor activity in two models with higher copy number of CCNE1.	AZD5438	23-30	cyclin dependent kinase 1	Homo sapiens	4-12
28629311-6	2018	Moreover, nitidine chloride downregulated Cyclin B1, CDK1 and Bcl-2, upregulated p27 and Bax, inactivated PARP, activated Caspase-3 in AML cells.	nitidine	10-27	cyclin dependent kinase 1	Homo sapiens	53-57
29669986-7	2018	We have also conducted phosphoproteomic analysis and identified Ki67 as a chromosomal cdk1 substrate whose dephosphorylation is facilitated by cyclin B1-separase interaction in anaphase.	ki67	64-68	cyclin dependent kinase 1	Homo sapiens	86-90
29285984-0	2018	Tetrandrine enhances radiosensitivity through the CDC25C/CDK1/cyclin B1 pathway in nasopharyngeal carcinoma cells.	tetrandrine	0-11	cyclin dependent kinase 1	Homo sapiens	57-61
29285984-11	2018	Combined treatment with the maximum non-cytotoxic dose of tetrandrine and irradiation caused suppression of the phosphorylation of CDK1 and CDC25C and increase in the expression of cyclin B1.	tetrandrine	58-69	cyclin dependent kinase 1	Homo sapiens	131-135
29285984-13	2018	Our results suggest that the maximum non-cytotoxic dose of tetrandrine can enhance the radiosensitivity of CNE1 and CNE2 cells and that the underlying mechanism could be associated with abrogation of radiation-induced G2/M arrest via activation of the CDC25C/CDK1/Cyclin B1 pathway.	tetrandrine	59-70	cyclin dependent kinase 1	Homo sapiens	259-263
29806604-11	2018	In silico docking studies predicted CDK1 and CDK6 as a possible target of C-glycosyl flavone.	c-glycosyl flavone	74-92	cyclin dependent kinase 1	Homo sapiens	36-40
30039733-5	2018	Thr-592 phosphorylation occurs first at the G1/S border and is removed during mitotic exit parallel with Thr-phosphorylations of most CDK1 targets.	Threonine	0-3	cyclin dependent kinase 1	Homo sapiens	134-138
30039733-5	2018	Thr-592 phosphorylation occurs first at the G1/S border and is removed during mitotic exit parallel with Thr-phosphorylations of most CDK1 targets.	Threonine	105-108	cyclin dependent kinase 1	Homo sapiens	134-138
30045664-3	2018	Radiosensitization by the specific CDK1 inhibitor, RO-3306, was determined by colony formation assays in three tumor lines (HeLa, T24, SQ20B) and three non-cancer lines (HFL1, MRC-5, RPE).	RO 3306	51-58	cyclin dependent kinase 1	Homo sapiens	35-39
29175378-0	2018	Increased activity of both CDK1 and CDK2 is necessary for the combinatorial activity of WEE1 inhibition and cytarabine.	Cytarabine	108-118	cyclin dependent kinase 1	Homo sapiens	27-31
29175378-5	2018	Expression of CDK1/2-AF together, but neither alone, enhanced the anti-proliferative effects, DNA damage and apoptosis induced by cytarabine.	Cytarabine	130-140	cyclin dependent kinase 1	Homo sapiens	14-18
29175378-6	2018	Furthermore, pharmacologic inhibition of CDK1 alone or CDK1 and CDK2 together reduced the combinatorial activity of AZD1775 and cytarabine.	adavosertib	116-123	cyclin dependent kinase 1	Homo sapiens	41-45
29175378-6	2018	Furthermore, pharmacologic inhibition of CDK1 alone or CDK1 and CDK2 together reduced the combinatorial activity of AZD1775 and cytarabine.	adavosertib	116-123	cyclin dependent kinase 1	Homo sapiens	55-59
29175378-6	2018	Furthermore, pharmacologic inhibition of CDK1 alone or CDK1 and CDK2 together reduced the combinatorial activity of AZD1775 and cytarabine.	Cytarabine	128-138	cyclin dependent kinase 1	Homo sapiens	41-45
29175378-6	2018	Furthermore, pharmacologic inhibition of CDK1 alone or CDK1 and CDK2 together reduced the combinatorial activity of AZD1775 and cytarabine.	Cytarabine	128-138	cyclin dependent kinase 1	Homo sapiens	55-59
29175378-7	2018	Thus, increased activity of both CDK1 and CDK2 in response to WEE1 inhibition is necessary for the combinatorial activity of AZD1775 and cytarabine.	adavosertib	125-132	cyclin dependent kinase 1	Homo sapiens	33-37
29175378-7	2018	Thus, increased activity of both CDK1 and CDK2 in response to WEE1 inhibition is necessary for the combinatorial activity of AZD1775 and cytarabine.	Cytarabine	137-147	cyclin dependent kinase 1	Homo sapiens	33-37
29074359-5	2017	Further investigation on Cdc25C/CDK1/CyclinB1 signaling cascade in the absence or presence of pharmacological DDR inhibitors showed that xanthatin directly destabilized the protein levels of Cdc25C, and recovery of p53 expression in p53-deficient H1299 cells further intensified xanthatin-mediated inhibition of Cdc25C, suggesting p53-dependent regulation of Cdc25C in a DDR machinery.	xanthatin	137-146	cyclin dependent kinase 1	Homo sapiens	32-36
29435156-0	2018	Cis-trimethoxy resveratrol induces intrinsic apoptosis via prometaphase arrest and prolonged CDK1 activation pathway in human Jurkat T cells.	cis-trimethoxy resveratrol	0-26	cyclin dependent kinase 1	Homo sapiens	93-97
29435156-5	2018	Cis-3M-RES-induced phosphorylation of BCL-2 family proteins and mitochondrial apoptotic events were suppressed by a validated CDK1 inhibitor RO3306.	cis-3m-res	0-10	cyclin dependent kinase 1	Homo sapiens	126-130
29435156-5	2018	Cis-3M-RES-induced phosphorylation of BCL-2 family proteins and mitochondrial apoptotic events were suppressed by a validated CDK1 inhibitor RO3306.	RO 3306	141-147	cyclin dependent kinase 1	Homo sapiens	126-130
29435156-10	2018	These results indicate that the antitumor activity of cis-3M-RES is mediated by microtubule damage, and subsequent prometaphase arrest and prolonged CDK1 activation that cause BAK-mediated mitochondrial apoptosis, and suggest that cis-3M-RES is a promising agent to treat leukemia.	cis-3m-res	54-64	cyclin dependent kinase 1	Homo sapiens	149-153
29229926-5	2017	During S/G2 phases, CDK1 and CDK2 (CDK1/2) phosphorylate RECQL4 on serines 89 and 251, enhancing MRE11/RECQL4 interaction and RECQL4 recruitment to DSBs.	Serine	67-74	cyclin dependent kinase 1	Homo sapiens	20-24
29229926-5	2017	During S/G2 phases, CDK1 and CDK2 (CDK1/2) phosphorylate RECQL4 on serines 89 and 251, enhancing MRE11/RECQL4 interaction and RECQL4 recruitment to DSBs.	1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione	148-152	cyclin dependent kinase 1	Homo sapiens	20-24
28946554-0	2017	MiR-181a inhibits non-small cell lung cancer cell proliferation by targeting CDK1.	181a	4-8	cyclin dependent kinase 1	Homo sapiens	77-81
29416675-2	2018	A previous pharmacogenomic study revealed the importance of cyclin-dependent kinase 1 (CDK1) activity in a response on paclitaxel.	Paclitaxel	119-129	cyclin dependent kinase 1	Homo sapiens	60-85
29416675-2	2018	A previous pharmacogenomic study revealed the importance of cyclin-dependent kinase 1 (CDK1) activity in a response on paclitaxel.	Paclitaxel	119-129	cyclin dependent kinase 1	Homo sapiens	87-91
29416675-5	2018	Our results suggest that treatment with the CDK1 inhibitor alsterpaullone reduces phosphorylation of caspase-9.	alsterpaullone	59-73	cyclin dependent kinase 1	Homo sapiens	44-48
29416675-6	2018	Its phosphorylation level was dependent on CDK1 activity and it directs paclitaxel resistance.	Paclitaxel	72-82	cyclin dependent kinase 1	Homo sapiens	43-47
29074254-0	2017	Discovery of a class of diheteroaromatic amines as orally bioavailable CDK1/4/6 inhibitors.	diheteroaromatic amines	24-47	cyclin dependent kinase 1	Homo sapiens	71-79
29074254-1	2017	The discovery of a class of diheteroaromatic amines based on LY2835219 as cyclin-dependent kinase (CDK1/4/6) inhibitors was described.	diheteroaromatic amines	28-51	cyclin dependent kinase 1	Homo sapiens	99-107
29074254-1	2017	The discovery of a class of diheteroaromatic amines based on LY2835219 as cyclin-dependent kinase (CDK1/4/6) inhibitors was described.	abemaciclib	61-70	cyclin dependent kinase 1	Homo sapiens	99-107
29074436-6	2017	DHPAC treatment also caused cell rest in G2/M phase by regulating of the expression of a number of cell cycle-related proteins (e.g. Cyclin B1, Cdc2, Cdc25b, Cdc25c, RSK2).	dhpac	0-5	cyclin dependent kinase 1	Homo sapiens	144-148
28804952-6	2017	In GBM 8401 cells, propofol induced G2/M phase cell arrest, which affected the CDK1, cyclin B1, p53, and p21 protein expression levels.	Propofol	19-27	cyclin dependent kinase 1	Homo sapiens	79-83
28912176-7	2017	Reverse phase protein analysis of ONO-7475 treated cells revealed that cell cycle regulators like cyclin dependent kinase 1, cyclin B1, polo-like kinase 1, and retinoblastoma were suppressed.	ONO-7475	34-42	cyclin dependent kinase 1	Homo sapiens	98-123
28912176-8	2017	ONO-7475 suppressed cyclin dependent kinase 1, cyclin B1, polo-like kinase 1 gene expression suggesting that anexelekto may regulate the cell cycle, at least in part, via transcriptional mechanisms.	ONO-7475	0-8	cyclin dependent kinase 1	Homo sapiens	20-45
29075787-9	2017	We suggest that intracellularly generated salicylic acid metabolites through CYP450 enzymes within the colonic epithelial cells, or the salicylic acid metabolites generated by gut microflora may significantly contribute to the preferential chemopreventive effect of aspirin against CRC through inhibition of CDKs.	Salicylic Acid	42-56	cyclin dependent kinase 1	Homo sapiens	308-312
28988508-5	2017	In this hypothesis generating study, the immunological alterations in circulating immune subsets induced by everolimus included a (non-significant) increase in the frequency of Tregs, a significant increase in monocytic myeloid-derived suppressor cells, a significant decrease in the frequency of immunoregulatory natural killer cells, classical CD141+ (cDC1) and CD1c+ (cDC2) dendritic cell subsets, as well as a decrease in the activation status of plasmacytoid dendritic cells and cDC1.	Everolimus	108-118	cyclin dependent kinase 1	Homo sapiens	371-375
29075787-4	2017	Using in vitro kinase assays, for the first time, we demonstrate that salicylic acid metabolites, 2,3-dihydroxybenzoic acid (2,3-DHBA) and 2,5-dihydroxybenzoic acid (2,5-DHBA), as well as derivatives 2,4-dihydroxybenzoic acid (2,4-DHBA), 2,6-dihydroxybenzoic acid (2,6-DHBA), inhibited CDK1 enzyme activity.	Salicylic Acid	70-84	cyclin dependent kinase 1	Homo sapiens	286-290
29084198-2	2017	Interestingly, threonine and serine residues phosphorylated by Cdk1 display distinct phosphorylation dynamics, but the biological significance remains unexplored.	Threonine	15-24	cyclin dependent kinase 1	Homo sapiens	63-67
29075787-4	2017	Using in vitro kinase assays, for the first time, we demonstrate that salicylic acid metabolites, 2,3-dihydroxybenzoic acid (2,3-DHBA) and 2,5-dihydroxybenzoic acid (2,5-DHBA), as well as derivatives 2,4-dihydroxybenzoic acid (2,4-DHBA), 2,6-dihydroxybenzoic acid (2,6-DHBA), inhibited CDK1 enzyme activity.	2,5-dihydroxybenzoic acid	139-164	cyclin dependent kinase 1	Homo sapiens	286-290
29075787-6	2017	Interestingly, another derivative, 2,4,6-trihydroxybenzoic acid (2,4,6-THBA) was highly effective in inhibiting CDK1, 2, 4 and 6 activity.	2,4,6-trihydroxybenzoic acid	35-63	cyclin dependent kinase 1	Homo sapiens	112-116
29075787-6	2017	Interestingly, another derivative, 2,4,6-trihydroxybenzoic acid (2,4,6-THBA) was highly effective in inhibiting CDK1, 2, 4 and 6 activity.	2,4,6-trihydroxybenzoic acid	65-75	cyclin dependent kinase 1	Homo sapiens	112-116
29075787-8	2017	Immunoblotting experiments showed that aspirin acetylated CDK1, and pre-incubation with salicylic acid and its derivatives prevented aspirin-mediated CDK1 acetylation, which supported the data obtained from molecular docking studies.	Aspirin	39-46	cyclin dependent kinase 1	Homo sapiens	58-62
29075787-8	2017	Immunoblotting experiments showed that aspirin acetylated CDK1, and pre-incubation with salicylic acid and its derivatives prevented aspirin-mediated CDK1 acetylation, which supported the data obtained from molecular docking studies.	Salicylic Acid	88-102	cyclin dependent kinase 1	Homo sapiens	150-154
29075787-8	2017	Immunoblotting experiments showed that aspirin acetylated CDK1, and pre-incubation with salicylic acid and its derivatives prevented aspirin-mediated CDK1 acetylation, which supported the data obtained from molecular docking studies.	Aspirin	133-140	cyclin dependent kinase 1	Homo sapiens	150-154
29084198-2	2017	Interestingly, threonine and serine residues phosphorylated by Cdk1 display distinct phosphorylation dynamics, but the biological significance remains unexplored.	Serine	29-35	cyclin dependent kinase 1	Homo sapiens	63-67
28935563-4	2017	Further study indicated that oridonin induced G2/M phase arrest in OSCC cells, which was associated with the downregulation of proteins related to G2/M transition including cdc25C, cdc2 and cyclin B1, as well as the upregulation of p53 and phosphorylated-cdc2.	oridonin	29-37	cyclin dependent kinase 1	Homo sapiens	173-177
28935563-4	2017	Further study indicated that oridonin induced G2/M phase arrest in OSCC cells, which was associated with the downregulation of proteins related to G2/M transition including cdc25C, cdc2 and cyclin B1, as well as the upregulation of p53 and phosphorylated-cdc2.	oridonin	29-37	cyclin dependent kinase 1	Homo sapiens	181-185
29371946-0	2017	Episode-like pulse testosterone supplementation induces tumor senescence and growth arrest down-modulating androgen receptor through modulation of p-ERK1/2, pARser81 and CDK1 signaling: biological implications for men treated with testosterone replacement therapy.	Testosterone	19-31	cyclin dependent kinase 1	Homo sapiens	170-174
29371946-0	2017	Episode-like pulse testosterone supplementation induces tumor senescence and growth arrest down-modulating androgen receptor through modulation of p-ERK1/2, pARser81 and CDK1 signaling: biological implications for men treated with testosterone replacement therapy.	Testosterone	231-243	cyclin dependent kinase 1	Homo sapiens	170-174
29290940-12	2017	LPC induced cell cycle arrest and apoptosis with concomitant inhibition of cdc2 and cyclin B1 expression.	Lysophosphatidylcholines	0-3	cyclin dependent kinase 1	Homo sapiens	75-79
29121949-6	2017	The BRCA2, CYP1A1, CYP1B1, CDK1, SFN and VEGFA genes were observed to be upregulated specifically from increased CdSe exposure and suggests their possible utility as biomarkers for toxicity.	cdse	113-117	cyclin dependent kinase 1	Homo sapiens	27-31
28857796-9	2017	Ropivacaine decreased the mRNA level of key cell cycle regulators, namely cyclin A2, cyclin B1, cyclin B2, and cyclin-dependent kinase 1, and the expression of the nuclear marker of cell proliferation MKI67.	Ropivacaine	0-11	cyclin dependent kinase 1	Homo sapiens	111-136
28869606-11	2017	Collectively, our study demonstrate that KCTD12 binds to CDC25B and activates CDK1 and Aurora A to facilitate the G2/M transition and promote tumorigenesis and that Aurora A phosphorylates KCTD12 at serine 243 to trigger a positive feedback loop, thereby potentiating the effects of KCTD12.	Serine	199-205	cyclin dependent kinase 1	Homo sapiens	78-82
28874101-4	2017	Expression knockdown of Cdk1 at the initiation of adipogenic induction resulted in significantly increased adipocytes, even though total number of cells was significantly reduced compared to siControl-treated cells.	sicontrol	191-200	cyclin dependent kinase 1	Homo sapiens	24-28
28598010-11	2017	Therefore, we suggest that through interaction with miR-490-3p, DLEU1 may influence the expression of CDK1, CCND1 and SMARCD1 protein, subsequently promoting the development and progression of EOC.	mir-490-3p	52-62	cyclin dependent kinase 1	Homo sapiens	102-106
28882785-9	2017	The expression of cyclin D1 and E was decreased and phosphorylation of CDK1 was increased by orlistat treatment in HSC-3 cells.	Orlistat	93-101	cyclin dependent kinase 1	Homo sapiens	71-75
28882785-10	2017	Thus, orlistat induces apoptosis and cell cycle arrest in G2/M phase in HSC-3 cells through decrease in expression of cyclin D1 and E and increase in phosphorylation of CDK1.	Orlistat	6-14	cyclin dependent kinase 1	Homo sapiens	169-173
29029741-1	2017	A novel native cyclodextrin (CD) chiral stationary phase (CSP) with single triazole-bridge at CD C2 position (CSP1) was prepared by anchoring mono(2A-azido-2A-deoxy)-beta-CD onto alkynyl silica via click chemistry.	Cyclodextrins	15-27	cyclin dependent kinase 1	Homo sapiens	94-99
29029741-1	2017	A novel native cyclodextrin (CD) chiral stationary phase (CSP) with single triazole-bridge at CD C2 position (CSP1) was prepared by anchoring mono(2A-azido-2A-deoxy)-beta-CD onto alkynyl silica via click chemistry.	Cyclodextrins	29-31	cyclin dependent kinase 1	Homo sapiens	94-99
29029741-1	2017	A novel native cyclodextrin (CD) chiral stationary phase (CSP) with single triazole-bridge at CD C2 position (CSP1) was prepared by anchoring mono(2A-azido-2A-deoxy)-beta-CD onto alkynyl silica via click chemistry.	Triazoles	75-83	cyclin dependent kinase 1	Homo sapiens	94-99
29190974-9	2017	In addition, we transfected with si (BIRC5, CDK1, NUF2, ZWINT and SPC24), to target genes that can be targeted by miR-3613-3p.	Silicon	33-35	cyclin dependent kinase 1	Homo sapiens	44-48
29207595-5	2017	Moreover, we show that compromised CDK1 activity dramatically increases the efficacy of chemotherapeutic agents that kill cancer cells through perturbing DNA replication, including Olaparib, an FDA approved PARP inhibitor.	olaparib	181-189	cyclin dependent kinase 1	Homo sapiens	35-39
28713965-8	2017	Furthermore, DHA and gefitinib co-administration induced cell cycle arrest in G2/M phase, which was associated with a marked decline in the protein expression levels of G2/M regulatory proteins, including cyclin B1 and cyclin-dependent kinase 1.	artenimol	13-16	cyclin dependent kinase 1	Homo sapiens	219-244
29044420-23	2017	The functional significance of DNM2 phosphorylation was illustrated by the fact that pharmacological inhibition of CDK1 elicited a concomitant suppression of both DNM2-Ser764 phosphorylation and the overall rates of progesterone-induced acrosomal exocytosis.	Progesterone	216-228	cyclin dependent kinase 1	Homo sapiens	115-119
28688277-0	2017	Synthesis, antitumor activity and CDK1 inhibiton of new thiazole nortopsentin analogues.	thiazole nortopsentin	56-77	cyclin dependent kinase 1	Homo sapiens	34-38
28688277-5	2017	The most active and selective of the new thiazoles confined viable cells in G2/M phase and markedly inhibited in vitro CDK1 activity.	Thiazoles	41-50	cyclin dependent kinase 1	Homo sapiens	119-123
29163782-4	2017	ATR subsequently phosphorylates H2AX at serine 139 (gammaH2AX) and CHK1 at serine 345 (CHK1pS345), leading to phosphorylation of CDK1 at tyrosine 15 (CDK1pY15) and S-phase arrest.	Serine	40-46	cyclin dependent kinase 1	Homo sapiens	129-133
29163782-4	2017	ATR subsequently phosphorylates H2AX at serine 139 (gammaH2AX) and CHK1 at serine 345 (CHK1pS345), leading to phosphorylation of CDK1 at tyrosine 15 (CDK1pY15) and S-phase arrest.	Serine	75-81	cyclin dependent kinase 1	Homo sapiens	129-133
29163782-4	2017	ATR subsequently phosphorylates H2AX at serine 139 (gammaH2AX) and CHK1 at serine 345 (CHK1pS345), leading to phosphorylation of CDK1 at tyrosine 15 (CDK1pY15) and S-phase arrest.	Tyrosine	137-145	cyclin dependent kinase 1	Homo sapiens	129-133
29245943-7	2017	Moreover, in the presence of CDDP, Ssd also down-regulates protein phosphatase magnesium-dependent 1 D (PPM1D) and increases the phosphorylation of checkpoint protein kinases (Chk) 1, cell division cycle 25c (Cdc25c) and Cyclin dependent kinase 1 (Cdk1).	Cisplatin	29-33	cyclin dependent kinase 1	Homo sapiens	221-246
29245943-7	2017	Moreover, in the presence of CDDP, Ssd also down-regulates protein phosphatase magnesium-dependent 1 D (PPM1D) and increases the phosphorylation of checkpoint protein kinases (Chk) 1, cell division cycle 25c (Cdc25c) and Cyclin dependent kinase 1 (Cdk1).	Cisplatin	29-33	cyclin dependent kinase 1	Homo sapiens	248-252
28815566-5	2017	The reduced intraoocyte cyclic nucleotides level is associated with the decrease of Cdc25B, Thr161 phosphorylated Cdk1 and Emi2 expression levels.	Nucleotides, Cyclic	24-42	cyclin dependent kinase 1	Homo sapiens	114-118
28950208-4	2017	Flowcytometry and immunoblot analysis confirmed that pelargonidin specifically inhibits the activation of CDK1 and blocks the G2-M transition of the cell cycle.	pelargonidin	53-65	cyclin dependent kinase 1	Homo sapiens	106-110
28950208-6	2017	Hence, the aim of the present study was to investigate the molecular mechanism of pelargonidin"s action on cell cycle regulators CDK1, CDK4, and CDK6 as well as the substrate-binding domain of DNMT1 and DNMT3A, which regulate the epigenetic signals related to DNA methylation.	pelargonidin	82-94	cyclin dependent kinase 1	Homo sapiens	129-133
28950208-7	2017	The results of docking analysis, binding free energy calculation, and molecular dynamics simulation correlated with the experimental results, and pelargonidin showed a specific interaction with CDK1.	pelargonidin	146-158	cyclin dependent kinase 1	Homo sapiens	194-198
28849003-8	2017	In addition, the cell cycle-related proteins, including p27, CHK1, cyclin D1, CDK1, p-AMP-activated protein kinase (AMPK) and p-protein kinase B (AKT), were regulated by chrysophanol nanoparticles to prevent human prostate cancer cell progression.	chrysophanic acid	170-182	cyclin dependent kinase 1	Homo sapiens	78-82
28300289-3	2017	Dehydrocostus lactone suppresses the expression of cyclin B1, cyclin A, cyclin E, cyclin-dependent kinase 2 (CDK2), and cyclin-dependent kinase 1 (CDK1) and increases p21 expression, resulting in S-G2/M phase arrest in K562 cells.	Lactones	14-21	cyclin dependent kinase 1	Homo sapiens	120-145
28300289-3	2017	Dehydrocostus lactone suppresses the expression of cyclin B1, cyclin A, cyclin E, cyclin-dependent kinase 2 (CDK2), and cyclin-dependent kinase 1 (CDK1) and increases p21 expression, resulting in S-G2/M phase arrest in K562 cells.	Lactones	14-21	cyclin dependent kinase 1	Homo sapiens	147-151
28117030-8	2017	SB203580 inhibited G2 phase arrest, suppression of CDC25C, and phosphorylation of CDC2 (Tyr15) induced by the TCTs.	SB 203580	0-8	cyclin dependent kinase 1	Homo sapiens	51-55
28678347-6	2017	Consistently, the CDK1 inhibitor RO-3306 is less active in a TRAP1-high background.	RO 3306	33-40	cyclin dependent kinase 1	Homo sapiens	18-22
28713965-8	2017	Furthermore, DHA and gefitinib co-administration induced cell cycle arrest in G2/M phase, which was associated with a marked decline in the protein expression levels of G2/M regulatory proteins, including cyclin B1 and cyclin-dependent kinase 1.	Gefitinib	21-30	cyclin dependent kinase 1	Homo sapiens	219-244
28808311-3	2017	CoQ0 induced G2/M arrest through downregulation of cyclin B1/A and CDK1/K2 expressions.	ubiquinone-O	0-4	cyclin dependent kinase 1	Homo sapiens	67-71
29109769-5	2017	DCZ3301 also inhibited cell cycling and caused a G2/M accumulation that corresponded with downregulation of Cdc25C, CDK1, and Cyclin B1.	DCZ3301	0-7	cyclin dependent kinase 1	Homo sapiens	116-120
28927115-9	2017	Results from the cell cycle analysis and western blotting indicated that MK1775 abrogated the G2/M checkpoint through inhibiting the phosphorylation of CDK1 and inducing the apoptosis of ovarian cancer cells that lacked mutations in p53 and breast cancer 1 (BRCA1).	adavosertib	73-79	cyclin dependent kinase 1	Homo sapiens	152-156
28703366-4	2017	Also, the combination of TAB induced G1 -phase cell-cycle arrest by downregulating the level of cyclin D1, cyclin E, and CDC2.	tab	25-28	cyclin dependent kinase 1	Homo sapiens	121-125
28591670-9	2017	Western blot analysis showed that compound 5b induces G2/M phase arrest via ROS mediated DNA-damage, which in turn, induces phosphorylation of Chk1/Cdc25c/Cdc2 pathway.	ros	76-79	cyclin dependent kinase 1	Homo sapiens	148-152
28726723-7	2017	Moreover, mertensene-induced G2/M cell cycle arrest was associated with a decrease in the phosphorylated forms of the anti-tumor transcription factor p53, retinoblastoma protein (Rb), cdc2 and chkp2.	Mertensene	10-20	cyclin dependent kinase 1	Homo sapiens	184-188
28534969-0	2017	The Cdc2/Cdk1 inhibitor, purvalanol A, enhances the cytotoxic effects of taxol through Op18/stathmin in non-small cell lung cancer cells in vitro.	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	25-37	cyclin dependent kinase 1	Homo sapiens	4-8
28450285-7	2017	In parallel, Cd induces AKT and cdc2 phosphorylation and downstream vimentin phosphorylation at Ser39 and Ser55, respectively.	Cadmium	13-15	cyclin dependent kinase 1	Homo sapiens	32-36
28450285-8	2017	AKT and cdc2 inhibitors block Cd-induced vimentin fragmentation and secretion in association with inhibition of alpha-SMA expression, ECM deposition, and collagen secretion.	Cadmium	30-32	cyclin dependent kinase 1	Homo sapiens	8-12
28534969-7	2017	Further experiments indicated that Cdc2 kinase activities, including the expression of Cdc2 and the level of phospho-Cdc2 (Thr161) were significantly higher in taxol-resistant NCI-H1299 cells compared with the relatively sensitive CNE1 cells before and following treatment with taxol.	Paclitaxel	160-165	cyclin dependent kinase 1	Homo sapiens	35-39
28534969-7	2017	Further experiments indicated that Cdc2 kinase activities, including the expression of Cdc2 and the level of phospho-Cdc2 (Thr161) were significantly higher in taxol-resistant NCI-H1299 cells compared with the relatively sensitive CNE1 cells before and following treatment with taxol.	Paclitaxel	160-165	cyclin dependent kinase 1	Homo sapiens	87-91
28534969-7	2017	Further experiments indicated that Cdc2 kinase activities, including the expression of Cdc2 and the level of phospho-Cdc2 (Thr161) were significantly higher in taxol-resistant NCI-H1299 cells compared with the relatively sensitive CNE1 cells before and following treatment with taxol.	Paclitaxel	160-165	cyclin dependent kinase 1	Homo sapiens	87-91
28534969-7	2017	Further experiments indicated that Cdc2 kinase activities, including the expression of Cdc2 and the level of phospho-Cdc2 (Thr161) were significantly higher in taxol-resistant NCI-H1299 cells compared with the relatively sensitive CNE1 cells before and following treatment with taxol.	Paclitaxel	278-283	cyclin dependent kinase 1	Homo sapiens	35-39
28534969-8	2017	These findings suggest that Cdc2 is positively associatd with the development of taxol resistance.	Paclitaxel	81-86	cyclin dependent kinase 1	Homo sapiens	28-32
28534969-9	2017	The Cdc2 inhibitor, purvalanol A, enhanced the cytotoxic effects of taxol through Op18/stathmin.	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	20-32	cyclin dependent kinase 1	Homo sapiens	4-8
28534969-0	2017	The Cdc2/Cdk1 inhibitor, purvalanol A, enhances the cytotoxic effects of taxol through Op18/stathmin in non-small cell lung cancer cells in vitro.	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	25-37	cyclin dependent kinase 1	Homo sapiens	9-13
28534969-0	2017	The Cdc2/Cdk1 inhibitor, purvalanol A, enhances the cytotoxic effects of taxol through Op18/stathmin in non-small cell lung cancer cells in vitro.	Paclitaxel	73-78	cyclin dependent kinase 1	Homo sapiens	4-8
28534969-0	2017	The Cdc2/Cdk1 inhibitor, purvalanol A, enhances the cytotoxic effects of taxol through Op18/stathmin in non-small cell lung cancer cells in vitro.	Paclitaxel	73-78	cyclin dependent kinase 1	Homo sapiens	9-13
28534969-1	2017	Purvalanol A is a highly selective inhibitor of Cdc2 [also known as cyclin-dependent kinase 1 (CDK1)].	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	0-12	cyclin dependent kinase 1	Homo sapiens	48-52
28534969-9	2017	The Cdc2 inhibitor, purvalanol A, enhanced the cytotoxic effects of taxol through Op18/stathmin.	Paclitaxel	68-73	cyclin dependent kinase 1	Homo sapiens	4-8
28534969-1	2017	Purvalanol A is a highly selective inhibitor of Cdc2 [also known as cyclin-dependent kinase 1 (CDK1)].	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	0-12	cyclin dependent kinase 1	Homo sapiens	68-93
28534969-1	2017	Purvalanol A is a highly selective inhibitor of Cdc2 [also known as cyclin-dependent kinase 1 (CDK1)].	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	0-12	cyclin dependent kinase 1	Homo sapiens	95-99
28534969-3	2017	In this study, the CDK1 inhibitor, purvalanol A was applied to explore the relevance of Cdc2 signaling and taxol sensitivity through analyses, such as cellular proliferation and apoptosis assays, ELISA, western blot analysis and immunoprecipitation.	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	35-47	cyclin dependent kinase 1	Homo sapiens	19-23
28534969-3	2017	In this study, the CDK1 inhibitor, purvalanol A was applied to explore the relevance of Cdc2 signaling and taxol sensitivity through analyses, such as cellular proliferation and apoptosis assays, ELISA, western blot analysis and immunoprecipitation.	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	35-47	cyclin dependent kinase 1	Homo sapiens	88-92
28534969-3	2017	In this study, the CDK1 inhibitor, purvalanol A was applied to explore the relevance of Cdc2 signaling and taxol sensitivity through analyses, such as cellular proliferation and apoptosis assays, ELISA, western blot analysis and immunoprecipitation.	Paclitaxel	107-112	cyclin dependent kinase 1	Homo sapiens	19-23
28416318-17	2017	U0126 (a MEK/ERK inhibitor) attenuated the bFGF-induced increase of cyclin B1, cdc2, and TIMP-1.	U 0126	0-5	cyclin dependent kinase 1	Homo sapiens	79-83
28977921-8	2017	Finally, complmentarity between CDK1 and three drugs, Aminophenazone, Pomalidomide and the Rosoxacin, implies novel pharmacological value of those drugs in breast cancer.	Aminopyrine	54-68	cyclin dependent kinase 1	Homo sapiens	32-36
28977921-8	2017	Finally, complmentarity between CDK1 and three drugs, Aminophenazone, Pomalidomide and the Rosoxacin, implies novel pharmacological value of those drugs in breast cancer.	pomalidomide	70-82	cyclin dependent kinase 1	Homo sapiens	32-36
28977921-8	2017	Finally, complmentarity between CDK1 and three drugs, Aminophenazone, Pomalidomide and the Rosoxacin, implies novel pharmacological value of those drugs in breast cancer.	rosoxacin	91-100	cyclin dependent kinase 1	Homo sapiens	32-36
27515506-9	2017	HSFs treated with GA at non-cytotoxic concentrations (50 to 75muM) significant increased both the S- and G2/M-phase HSFs population, and this event was accompanied with down-regulation of cyclin A, cyclin B, CDK1 and CDK2.	Gallic Acid	18-20	cyclin dependent kinase 1	Homo sapiens	208-212
28475750-9	2017	It was shown that ATX improved radiosensitivity of ESCC cells and induced apoptosis and G2/M arrest via inhibiting Bcl2, CyclinB1, Cdc2, and promoting Bax expression.	astaxanthine	18-21	cyclin dependent kinase 1	Homo sapiens	131-135
28476040-5	2017	Ganetespib decreased cyclin-dependent kinase 1 and arrested cell cycle progression in G2/M phase.	STA 9090	0-10	cyclin dependent kinase 1	Homo sapiens	21-46
28410121-5	2017	The reduced cyclic nucleotides level modulate specific phosphorylation status of cyclin-dependent kinase 1 (Cdk1) and triggers cyclin B1 degradation.	Nucleotides, Cyclic	12-30	cyclin dependent kinase 1	Homo sapiens	81-106
28410121-5	2017	The reduced cyclic nucleotides level modulate specific phosphorylation status of cyclin-dependent kinase 1 (Cdk1) and triggers cyclin B1 degradation.	Nucleotides, Cyclic	12-30	cyclin dependent kinase 1	Homo sapiens	108-112
28434945-8	2017	In cellular models, inhibition of CDK1 by siRNA or a specific inhibitor, RO-3306, reduced cellular proliferation and viability for HCC cells.	RO 3306	73-80	cyclin dependent kinase 1	Homo sapiens	34-38
29088738-8	2017	Consistent with an arrest in mitosis, MK-1775 treated prometaphase cells maintained high cyclin B1 and low phospho-tyrosine 15 Cdk1.	adavosertib	38-45	cyclin dependent kinase 1	Homo sapiens	127-131
28559969-0	2017	Escape of U251 glioma cells from temozolomide-induced senescence was modulated by CDK1/survivin signaling.	Temozolomide	33-45	cyclin dependent kinase 1	Homo sapiens	82-86
28292011-5	2017	Further study of the molecular mechanisms of this cytotoxic compound demonstrated that Jatamanvaltrate P enhanced cleavage of PARP and caspases, while decreased the expression levels of cell cycle-related Cyclin B1, Cyclin D1 and Cdc-2.	jatamanvaltrate P	87-104	cyclin dependent kinase 1	Homo sapiens	230-235
28126652-2	2017	The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then mediates a variety of cellular processes.	Guanosine Triphosphate	65-68	cyclin dependent kinase 1	Homo sapiens	91-95
28381539-5	2017	Intravital Forster resonance energy transfer imaging of a cyclin-dependent kinase 1 biosensor to monitor the efficacy of cytotoxic drugs revealed that priming improves pancreatic cancer response to gemcitabine/Abraxane at both primary and secondary sites.	gemcitabine	198-209	cyclin dependent kinase 1	Homo sapiens	58-83
28216618-5	2017	The signaling pathways involved in DAG-caused cell cycle arrest was further analyzed in LN229 cells, which revealed that DAG dose-dependently activated two parallel signaling cascades, ie, the p53-p21 cascade and the CDC25C-CDK1 cascade.	Dianhydrogalactitol	35-38	cyclin dependent kinase 1	Homo sapiens	224-228
28216618-5	2017	The signaling pathways involved in DAG-caused cell cycle arrest was further analyzed in LN229 cells, which revealed that DAG dose-dependently activated two parallel signaling cascades, ie, the p53-p21 cascade and the CDC25C-CDK1 cascade.	Dianhydrogalactitol	121-124	cyclin dependent kinase 1	Homo sapiens	224-228
28216618-8	2017	In addition, DAG administration significantly activated the CDC25C-CDK1 cascade in the xenografted tumors.	Dianhydrogalactitol	13-16	cyclin dependent kinase 1	Homo sapiens	67-71
28454475-5	2017	Detailed signaling pathway analysis by western blotting demonstrated that the expression levels of p53 and p21 were upregulated, whereas the expression of cyclin-dependent kinase 1 was downregulated following oridonin treatment, which led to cell cycle arrest in the G2/M phase.	oridonin	209-217	cyclin dependent kinase 1	Homo sapiens	155-180
28335434-4	2017	FKA induces G2M arrest in cell cycle progression of HER2-overexpressing breast cancer cell lines through inhibition of Cdc2 and Cdc25C phosphorylation and downregulation of expression of Myt1 and Wee1 leading to increased Cdc2 kinase activities.	flavokawain A	0-3	cyclin dependent kinase 1	Homo sapiens	128-132
27585443-8	2017	Besides, Oroxylin A could obviously radiosensitize ESCC cells by arresting tumor cells in G2/M phase and regulating cyclin B1 and Cdc 2 protein expression.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	9-19	cyclin dependent kinase 1	Homo sapiens	130-135
28335434-4	2017	FKA induces G2M arrest in cell cycle progression of HER2-overexpressing breast cancer cell lines through inhibition of Cdc2 and Cdc25C phosphorylation and downregulation of expression of Myt1 and Wee1 leading to increased Cdc2 kinase activities.	flavokawain A	0-3	cyclin dependent kinase 1	Homo sapiens	119-123
28005359-1	2017	Purines and related heterocycles substituted at C-2 with 4"-sulfamoylanilino and at C-6 with a variety of groups have been synthesized with the aim of achieving selectivity of binding to CDK2 over CDK1.	Purines	0-7	cyclin dependent kinase 1	Homo sapiens	197-201
28005359-2	2017	6-Substituents that favor competitive inhibition at the ATP binding site of CDK2 were identified and typically exhibited 10-80-fold greater inhibition of CDK2 compared to CDK1.	Adenosine Triphosphate	56-59	cyclin dependent kinase 1	Homo sapiens	171-175
28005359-3	2017	Most impressive was 4-((6-([1,1"-biphenyl]-3-yl)-9H-purin-2-yl)amino) benzenesulfonamide (73) that exhibited high potency toward CDK2 (IC50 0.044 muM) but was ~2000-fold less active toward CDK1 (IC50 86 muM).	4-((6-([1,1"-biphenyl]-3-yl)-9h-purin-2-yl)amino) benzenesulfonamide	20-88	cyclin dependent kinase 1	Homo sapiens	189-193
28264028-6	2017	Activated ATR phosphorylated CDC25C at serine 216, which in turn inactivated the cyclin B/CDK1 complex without affecting nuclear import of the complex.	Serine	39-45	cyclin dependent kinase 1	Homo sapiens	90-94
27662514-7	2017	Reduction of intraoocyte cAMP level modulates phosphorylation status of cyclin-dependent kinase 1 (Cdk1) and triggers cyclin B1 degradation that destabilizes maturation promoting factor (MPF) and/or increases Cdk1 activity.	Cyclic AMP	25-29	cyclin dependent kinase 1	Homo sapiens	72-97
27662514-7	2017	Reduction of intraoocyte cAMP level modulates phosphorylation status of cyclin-dependent kinase 1 (Cdk1) and triggers cyclin B1 degradation that destabilizes maturation promoting factor (MPF) and/or increases Cdk1 activity.	Cyclic AMP	25-29	cyclin dependent kinase 1	Homo sapiens	99-103
27662514-7	2017	Reduction of intraoocyte cAMP level modulates phosphorylation status of cyclin-dependent kinase 1 (Cdk1) and triggers cyclin B1 degradation that destabilizes maturation promoting factor (MPF) and/or increases Cdk1 activity.	Cyclic AMP	25-29	cyclin dependent kinase 1	Homo sapiens	209-213
28345462-8	2017	The phosphorylation of CDC2 was significantly induced by dihydrotestosterone and fibroblast growth factor 8b synergetically, and Smad underwent the same induction as CDC2.	Dihydrotestosterone	57-76	cyclin dependent kinase 1	Homo sapiens	23-27
27956520-4	2017	BTMB inhibited the expression of beta-catenin, cdc2 and the cell-cycle regulatory proteins, cyclin A, cyclin D1, and cyclin E. The mechanism of action was associated with the suppression of cell survival signaling through inactivation of the Akt and ERK1/2 signaling pathways.	3,5-Bis(trimethylsilyl)benzoic acid	0-4	cyclin dependent kinase 1	Homo sapiens	47-51
28184928-5	2017	Furthermore, we demonstrated that osthole not only contributed to cell cycle G2/M phase arrest via downregulation of Cdc2 and cyclin B1 levels, but also induced DNA damage via an increase in ERCC1 expression.	osthol	34-41	cyclin dependent kinase 1	Homo sapiens	117-121
28347224-2	2017	Our study revealed that crocodile choline led to cell cycle arrest at the G2/M phase through attenuating the expressions of cyclins, Cyclin B1, and CDK-1.	Choline	34-41	cyclin dependent kinase 1	Homo sapiens	148-153
28035361-6	2017	An increase in the total apoptotic cells and G2/M cell cycle arrest with decreased protein expression of CDC25C, CDK1, cyclin B1 and p21 were observed in Hep3B cells treated with flavonoids of C. platymamma.	Flavonoids	179-189	cyclin dependent kinase 1	Homo sapiens	113-117
28024945-3	2017	As a multi-targeted agent, MC37 inhibited the intracellular microtubule assembly, altered the expression of cyclin-dependent kinase 1 (CDK1), and ultimately induced G2/M cell cycle arrest.	mc37	27-31	cyclin dependent kinase 1	Homo sapiens	108-133
28024945-3	2017	As a multi-targeted agent, MC37 inhibited the intracellular microtubule assembly, altered the expression of cyclin-dependent kinase 1 (CDK1), and ultimately induced G2/M cell cycle arrest.	mc37	27-31	cyclin dependent kinase 1	Homo sapiens	135-139
28055975-7	2017	BTZ stabilized p21, CDC2, and cyclin B in RRCL and in primary tumor cells.	Bortezomib	0-3	cyclin dependent kinase 1	Homo sapiens	20-24
28207834-10	2017	Dinaciclib decreased CDK1, cyclin B1, and Aurora A expression, induced cell cycle arrest in the G2/M phase, and induced accumulation of prophase mitotic cells.	dinaciclib	0-10	cyclin dependent kinase 1	Homo sapiens	21-25
27791484-3	2017	Here we discuss the recent observation that the mRNA cap methyltransferase, RNMT, is phosphorylated on Thr-77 by CDK1-cyclin B1, which regulates its activity and the proteins with which it interacts.	Threonine	103-106	cyclin dependent kinase 1	Homo sapiens	113-117
28094374-1	2017	The intercalation of different pyrazines (pyrazine, methylpyrazine, 2,5-dimethylpyrazine, 2,3-dimethylpyrazine, trimethylpyrazine and tetramethylpyrazine) into the trans-1,4-cyclohexanedicarboxylate (CDC2-) based Al-MOF [Al(OH)(CDC)], denoted as CAU-13, was investigated.	trans-1,4-cyclohexanedicarboxylate	164-198	cyclin dependent kinase 1	Homo sapiens	200-204
28176922-6	2017	Pharmacological inhibition of CDK1/2 by flavopiridol or E2F1 with HLM006474 led to downregulation of Mad2 expression and prevented the increase of Mad2 expression by Skp2.	alvocidib	40-52	cyclin dependent kinase 1	Homo sapiens	30-34
27815502-3	2016	We and others have reported that human SAMHD1 interacts with the cell cycle regulatory proteins cyclin A, CDK1, and CDK2, which mediates phosphorylation of SAMHD1 at threonine 592, a post-translational modification that has been implicated in abrogating SAMHD1 restriction function and ability to form stable tetramers.	Threonine	166-175	cyclin dependent kinase 1	Homo sapiens	106-110
29093337-6	2017	Among these bisphenols, BPAF up-regulated the expression of ERbeta, and this was coupled with the abrogation of estrogen response element (ERE)-mediated transcriptional activities as well as the down-regulation of Cdc2 expression in MCF-7 cells, without influencing the expression of ERalpha.	4,4'-hexafluorisopropylidene diphenol	24-28	cyclin dependent kinase 1	Homo sapiens	214-218
27716745-5	2017	We determined that ANCR potentiated the CDK1-EZH2 interaction, which then increased the intensity of phosphorylation at Thr-345 and Thr-487 sites of EZH2, facilitating EZH2 ubiquitination and hence its degradation.	Threonine	132-135	cyclin dependent kinase 1	Homo sapiens	40-44
29055954-9	2017	Western blotting confirmed that a higher concentration of artesunate reduced the expression levels of beta-catenin, cyclin A, cyclin D1 and CDK1 and increased the expression levels of cyclin B1; however, artesunate had no impact on CDK2 expression in MG-63 cells.	Artesunate	58-68	cyclin dependent kinase 1	Homo sapiens	140-144
27713084-8	2016	Finally, CDK1 activity was involved in PAB-induced mitotic arrest and apoptosis in CRC cells.	pseudolaric acid B	39-42	cyclin dependent kinase 1	Homo sapiens	9-13
27863441-5	2016	SFN induced a marked decrease in the cell cycle activating proteins cdk1 and cyclin B and siRNA knock-down of cdk1 and cyclin B resulted in significantly diminished RCC cell growth.	sulforaphane	0-3	cyclin dependent kinase 1	Homo sapiens	68-72
27716745-5	2017	We determined that ANCR potentiated the CDK1-EZH2 interaction, which then increased the intensity of phosphorylation at Thr-345 and Thr-487 sites of EZH2, facilitating EZH2 ubiquitination and hence its degradation.	Threonine	120-123	cyclin dependent kinase 1	Homo sapiens	40-44
27720946-6	2016	Furthermore, overexpression of AKT protein significantly reduced DIMN-26-induced PARP-1 cleavage and p-Bad decrease and cdc2 activation.	dimn-26	65-72	cyclin dependent kinase 1	Homo sapiens	120-124
28040131-10	2016	Carfilzomib treatment significantly induced p21Waf1/ Cip1 and p27, while substantially reduced cyclin D3 and cyclin-dependent kinase 1.	carfilzomib	0-11	cyclin dependent kinase 1	Homo sapiens	109-134
27909289-6	2016	Heat shock/17-DMAG co-treatment of HCC cells also destabilized CDK1, Cyclin B1 and CDC25C with a concomitant decreased proportion of cells in the M phase.	17-(dimethylaminoethylamino)-17-demethoxygeldanamycin	11-18	cyclin dependent kinase 1	Homo sapiens	63-67
27566175-4	2016	We found that the mitotic kinase cyclin-dependent kinase 1 (CDK1) phosphorylates MST2 in vitro and in vivo at serine 385 during antimitotic drug-induced G2/M phase arrest.	Serine	110-116	cyclin dependent kinase 1	Homo sapiens	60-64
27748898-7	2016	Moreover, our results indicate that angelicin inhibits NSCLC growth not only by downregulating cyclin B1, cyclin E1 and Cdc2, which are related to the cell cycle, but also by reducing MMP2 and MMP9 and increasing E-cadherin expression levels.	angelicin	36-45	cyclin dependent kinase 1	Homo sapiens	120-124
28040131-11	2016	CONCLUSION: This study showed that carfilzomib inhibited endometrial cancer proliferation by upregulating cyclin-dependent kinase inhibitors p21Waf1/Cip1 and p27Kip1, and reducing cyclin-dependent kinase 1 to arrest the cell cycle at the G2/M phase.	carfilzomib	35-46	cyclin dependent kinase 1	Homo sapiens	180-205
27893752-9	2016	The mRNA expression of cdc2 and cyclin-B1 decreased after exposure to butyrate.	Butyrates	70-78	cyclin dependent kinase 1	Homo sapiens	23-27
27644244-8	2016	Furthermore, the p38/mitogen-activated protein kinase (MAPK) inhibitor SB203580 reversed the increase of the expression level of p38, p-cdc2 (Tyr15), cleaved caspase 3, cleaved PARP, p-p53, and p53 and reversed the decrease in cdc25B expression.	SB 203580	71-79	cyclin dependent kinase 1	Homo sapiens	136-140
28009971-11	2016	Cdk1 and Cdk2 protein levels declined after dacomitinib treatment; epithelial-mesenchymal transition (EMT) was inhibited, which was confirmed by observing E-cadherin, N-cadherin, and slug inhibition.	dacomitinib	44-55	cyclin dependent kinase 1	Homo sapiens	0-4
27550941-0	2016	Dinaciclib Induces Anaphase Catastrophe in Lung Cancer Cells via Inhibition of Cyclin-Dependent Kinases 1 and 2.	dinaciclib	0-10	cyclin dependent kinase 1	Homo sapiens	79-111
27644244-9	2016	In conclusion, these results demonstrated that PP-22 activated p38, inhibited cdc25B, increased p-cdc2 (Tyr15), and triggered S and G2/M phase arrest, as well as activated p53 through the p38-p53 pathway, inhibited the MAPK/ERK pathway, activated the caspase 8/caspase 3 pathway, and triggered the extrinsic apoptotic pathway in SCC-15 cells.	CHEMBL86597	47-52	cyclin dependent kinase 1	Homo sapiens	78-82
27626412-0	2016	Sulforaphane, a Dietary Isothiocyanate, Induces G2/M Arrest in Cervical Cancer Cells through CyclinB1 Downregulation and GADD45beta/CDC2 Association.	sulforaphane	0-12	cyclin dependent kinase 1	Homo sapiens	132-136
27344493-0	2016	Design, synthesis and biological evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-1,3-diphenyl-1H-pyrazole-4-carboxamides as CDK1/Cdc2 inhibitors.	n-((1-benzyl-1h-1,2,3-triazol-4-yl)methyl)-1,3-diphenyl-1h-pyrazole-4-carboxamides	47-129	cyclin dependent kinase 1	Homo sapiens	133-137
27344493-0	2016	Design, synthesis and biological evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-1,3-diphenyl-1H-pyrazole-4-carboxamides as CDK1/Cdc2 inhibitors.	n-((1-benzyl-1h-1,2,3-triazol-4-yl)methyl)-1,3-diphenyl-1h-pyrazole-4-carboxamides	47-129	cyclin dependent kinase 1	Homo sapiens	138-142
27344493-1	2016	A series of new (N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-1,3-diphenyl-1H-pyrazole-4-carboxamide derivatives (8-35) were designed, synthesized and evaluated as CDK1/Cdc2 inhibitors.	n-((1-benzyl-1h-1,2,3-triazol-4-yl)methyl)-1,3-diphenyl-1h-pyrazole-4-carboxamide	17-98	cyclin dependent kinase 1	Homo sapiens	162-166
27344493-1	2016	A series of new (N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-1,3-diphenyl-1H-pyrazole-4-carboxamide derivatives (8-35) were designed, synthesized and evaluated as CDK1/Cdc2 inhibitors.	n-((1-benzyl-1h-1,2,3-triazol-4-yl)methyl)-1,3-diphenyl-1h-pyrazole-4-carboxamide	17-98	cyclin dependent kinase 1	Homo sapiens	167-171
27579997-7	2016	This process is initiated by the phosphorylation of a specific serine residue in nuclear SREBP1 by the mitotic kinase Cdk1.	Serine	63-69	cyclin dependent kinase 1	Homo sapiens	118-122
27535497-5	2016	PZ-DHA also arrested MDA-MB-231 cell division at the G2/M phase and down-regulated expression of cyclin B1 and cyclin-dependent kinase 1 (CDK1).	Docosahexaenoic Acids	3-6	cyclin dependent kinase 1	Homo sapiens	111-136
27535497-5	2016	PZ-DHA also arrested MDA-MB-231 cell division at the G2/M phase and down-regulated expression of cyclin B1 and cyclin-dependent kinase 1 (CDK1).	Docosahexaenoic Acids	3-6	cyclin dependent kinase 1	Homo sapiens	138-142
27461132-0	2016	CCY-1a-E2 induces G2/M phase arrest and apoptotic cell death in HL-60 leukemia cells through cyclin-dependent kinase 1 signaling and the mitochondria-dependent caspase pathway.	ccy-1a-e2	0-9	cyclin dependent kinase 1	Homo sapiens	93-118
27611665-4	2016	Cdc6 depletion by RNAi or Norcantharidin inhibited PTX-induced Cdc6 up-regulation, maintained Cdk1 activity, and repressed Cohesin/Rad21 cleavage.	Paclitaxel	51-54	cyclin dependent kinase 1	Homo sapiens	94-98
27603133-4	2016	Furthermore, p17 was found to occupy the Plk1-binding site within the vimentin, thereby blocking Plk1 recruitment to CDK1-induced vimentin phosphorylation at Ser 56.	Serine	158-161	cyclin dependent kinase 1	Homo sapiens	117-121
27603133-5	2016	Interaction of p17 to CDK1 or vimentin interferes with CDK1-catalyzed phosphorylation of vimentin at Ser 56 and subsequently vimentin phosphorylation at Ser 82 by Plk1.	Serine	101-104	cyclin dependent kinase 1	Homo sapiens	22-26
27603133-5	2016	Interaction of p17 to CDK1 or vimentin interferes with CDK1-catalyzed phosphorylation of vimentin at Ser 56 and subsequently vimentin phosphorylation at Ser 82 by Plk1.	Serine	101-104	cyclin dependent kinase 1	Homo sapiens	55-59
27603133-5	2016	Interaction of p17 to CDK1 or vimentin interferes with CDK1-catalyzed phosphorylation of vimentin at Ser 56 and subsequently vimentin phosphorylation at Ser 82 by Plk1.	Serine	153-156	cyclin dependent kinase 1	Homo sapiens	22-26
27603133-5	2016	Interaction of p17 to CDK1 or vimentin interferes with CDK1-catalyzed phosphorylation of vimentin at Ser 56 and subsequently vimentin phosphorylation at Ser 82 by Plk1.	Serine	153-156	cyclin dependent kinase 1	Homo sapiens	55-59
27603133-6	2016	Furthermore, we have identified upstream signaling pathways and cellular factor(s) targeted by p17 and found that p17 regulates inhibitory phosphorylation of CDK1 and blocks vimentin phosphorylation at Ser 56 and Ser 82.	Serine	202-205	cyclin dependent kinase 1	Homo sapiens	158-162
27603133-6	2016	Furthermore, we have identified upstream signaling pathways and cellular factor(s) targeted by p17 and found that p17 regulates inhibitory phosphorylation of CDK1 and blocks vimentin phosphorylation at Ser 56 and Ser 82.	Serine	213-216	cyclin dependent kinase 1	Homo sapiens	158-162
27640744-5	2016	In ZR-75-1 cells, cytochalasin B triggered G2/M phase arrest through the modulation of CDK1, cyclin B1, p53, p27 and p21 expressions.	Cytochalasin B	18-32	cyclin dependent kinase 1	Homo sapiens	87-91
27325694-5	2016	During prophase, the mitotic spindle protein Spag5/Astrin is transported into centrosomes by Kinastrin and phosphorylated at Ser-135 and Ser-249 by Cdk1, which, in prometaphase, is loaded onto the spindle and targeted to KTs.	Serine	137-140	cyclin dependent kinase 1	Homo sapiens	148-152
27486754-7	2016	These data support the importance of CDK9, in addition to CDK1, in mediating the growth inhibitory effect of dinaciclib in TNBC.	dinaciclib	109-119	cyclin dependent kinase 1	Homo sapiens	58-62
27134283-4	2016	To increase our understanding of Cdk1-dependent phosphorylation pathways in mitosis, we conducted a quantitative phosphoproteomics analysis in mitotic HeLa cells using two small molecule inhibitors of Cdk1, Flavopiridol and RO-3306.	RO 3306	224-231	cyclin dependent kinase 1	Homo sapiens	33-37
27385216-6	2016	When the expression and activity of Cdk1 were inhibited by si-Cdk1 or RO-3306 which is a potent Cdk1 inhibitor, the growth of ovarian cancer was diminished.	RO 3306	70-77	cyclin dependent kinase 1	Homo sapiens	36-40
27226586-3	2016	We found that Ajuba is phosphorylated in vitro and in vivo by cyclin-dependent kinase 1 (CDK1) at Ser(119) and Ser(175) during the G2/M phase of the cell cycle.	Serine	98-101	cyclin dependent kinase 1	Homo sapiens	62-87
27226586-3	2016	We found that Ajuba is phosphorylated in vitro and in vivo by cyclin-dependent kinase 1 (CDK1) at Ser(119) and Ser(175) during the G2/M phase of the cell cycle.	Serine	98-101	cyclin dependent kinase 1	Homo sapiens	89-93
27685914-6	2016	Silibinin-doxorubicin combination also inhibited cdc2/p34 kinase activity when histone H1 was used as substrate.	silibinin-doxorubicin	0-21	cyclin dependent kinase 1	Homo sapiens	49-53
27517610-0	2016	Flavonoids as CDK1 Inhibitors: Insights in Their Binding Orientations and Structure-Activity Relationship.	Flavonoids	0-10	cyclin dependent kinase 1	Homo sapiens	14-18
27517610-4	2016	With this in mind, we studied the binding modes of 37 flavonoids (flavones and chalcones) inside the cyclin-dependent PK CDK1 using docking experiments.	Flavonoids	54-64	cyclin dependent kinase 1	Homo sapiens	121-125
27517610-4	2016	With this in mind, we studied the binding modes of 37 flavonoids (flavones and chalcones) inside the cyclin-dependent PK CDK1 using docking experiments.	Flavones	66-74	cyclin dependent kinase 1	Homo sapiens	121-125
27517610-4	2016	With this in mind, we studied the binding modes of 37 flavonoids (flavones and chalcones) inside the cyclin-dependent PK CDK1 using docking experiments.	Chalcones	79-88	cyclin dependent kinase 1	Homo sapiens	121-125
27517610-6	2016	In addition, quantitative structure-activity relationship (QSAR) models using CoMFA and CoMSIA methodologies were constructed to explain the trend of the CDK1 inhibitory activities for the studied flavonoids.	Flavonoids	197-207	cyclin dependent kinase 1	Homo sapiens	154-158
27517610-9	2016	Adequate R2 and Q2 values were obtained by each method; interestingly, only hydrophobic and hydrogen bond donor fields describe the differential potency of the flavonoids as CDK1 inhibitors for both defined alignments and subsets.	Flavonoids	160-170	cyclin dependent kinase 1	Homo sapiens	174-178
27212103-0	2016	Jumping the nuclear envelop barrier: Improving polyplex-mediated gene transfection efficiency by a selective CDK1 inhibitor RO-3306.	RO 3306	124-131	cyclin dependent kinase 1	Homo sapiens	109-113
27212103-4	2016	To jump the nuclear envelope barrier, we used a selective and reversible CDK1 inhibitor RO-3306 to control the G2/M transition of the cell cycle and increased the proportion of mitotic cells which have disappeared nuclear envelope during transfection.	RO 3306	88-95	cyclin dependent kinase 1	Homo sapiens	73-77
27120680-4	2016	Moreover, the inhibition effect of inhibitors on multiple kinases could be simultaneously readout in a single electrophoretic run, with half maximal inhibitory concentration of H-89 for PKA and Ro-3306 for CDK1 calculated as 37.0 and 35.9 nM, respectively, consistent with literatures reported.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	177-181	cyclin dependent kinase 1	Homo sapiens	206-210
27120680-4	2016	Moreover, the inhibition effect of inhibitors on multiple kinases could be simultaneously readout in a single electrophoretic run, with half maximal inhibitory concentration of H-89 for PKA and Ro-3306 for CDK1 calculated as 37.0 and 35.9 nM, respectively, consistent with literatures reported.	RO 3306	194-201	cyclin dependent kinase 1	Homo sapiens	206-210
26975930-7	2016	RESULTS: Our analysis of the Oncomine database found high levels of CDK1 and other cell cycle regulators indicative of Wee1 sensitivity in HCC.	oncomine	29-37	cyclin dependent kinase 1	Homo sapiens	68-72
27081912-6	2016	The results showed that polydatin inhibited VSMC proliferation and the level of reactive oxygen species, increased the expression of Kip1/p27, SIRT1 and eNOS, whereas the expression of cyclin B1, Cdk1 and c-myc was decreased.	polydatin	24-33	cyclin dependent kinase 1	Homo sapiens	196-200
27238018-5	2016	Cyclin-dependent kinase 1 (CDK1)-mediated phosphorylation of REV-ERBalpha is necessary for FBXW7 recognition.	rev-erbalpha	61-73	cyclin dependent kinase 1	Homo sapiens	0-25
27238018-5	2016	Cyclin-dependent kinase 1 (CDK1)-mediated phosphorylation of REV-ERBalpha is necessary for FBXW7 recognition.	rev-erbalpha	61-73	cyclin dependent kinase 1	Homo sapiens	27-31
27109601-7	2016	Treatment with metformin also induced cell cycle arrest in UVC-induced cells, in correlation with a reduction in the levels of cyclin E/cdk2/Rb and cyclin B1/cdk1.	Metformin	15-24	cyclin dependent kinase 1	Homo sapiens	158-162
27252650-12	2016	The S phase arrest was accompanied by the upregulation of ATM, P-Cdc2 (Tyr15), Myt1, P-Wee1 (Ser642), p21 and Cyclin B1, suggesting that blocking of Cdc2 activation may play an important role in bakuchiol-induced S phase arrest.	bakuchiol	195-204	cyclin dependent kinase 1	Homo sapiens	149-153
27050151-8	2016	The ORL lines noted to be enriched in cell cycle genes responded preferentially to the CDK1 inhibitor RO3306, by MTT cell viability assay.	RO 3306	102-108	cyclin dependent kinase 1	Homo sapiens	87-91
27070276-7	2016	Furthermore, the timing of the inhibitory tyrosine phosphorylation of Cyclin Dependent Kinase 1 (CDK1) was altered in the OGA knockdown cells.	Tyrosine	42-50	cyclin dependent kinase 1	Homo sapiens	70-95
27070276-7	2016	Furthermore, the timing of the inhibitory tyrosine phosphorylation of Cyclin Dependent Kinase 1 (CDK1) was altered in the OGA knockdown cells.	Tyrosine	42-50	cyclin dependent kinase 1	Homo sapiens	97-101
27050151-8	2016	The ORL lines noted to be enriched in cell cycle genes responded preferentially to the CDK1 inhibitor RO3306, by MTT cell viability assay.	monooxyethylene trimethylolpropane tristearate	113-116	cyclin dependent kinase 1	Homo sapiens	87-91
26918318-4	2016	Sulforaphene induced G2/M phase cell cycle arrest and apoptosis of colon cancer cells analyzed by flow cytometry, concomitant with phosphorylation of CDK1 and CDC25B at inhibitory sites, and upregulation of the p38 and JNK pathways.	sulphoraphene	0-12	cyclin dependent kinase 1	Homo sapiens	150-154
26913578-7	2016	The reduced cyclic nucleotide levels were associated with decreased Thr161 phosphorylated Cdk1 and cyclin B1 level but increased Thr14/Tyr15 phosphorylated Cdk1 level leading to maturation promoting factor destabilization.	Nucleotides, Cyclic	12-29	cyclin dependent kinase 1	Homo sapiens	90-94
26913578-7	2016	The reduced cyclic nucleotide levels were associated with decreased Thr161 phosphorylated Cdk1 and cyclin B1 level but increased Thr14/Tyr15 phosphorylated Cdk1 level leading to maturation promoting factor destabilization.	Nucleotides, Cyclic	12-29	cyclin dependent kinase 1	Homo sapiens	156-160
27123550-5	2016	DPD could also induce the cell cycle arrest at G2/M phase in HeLa cells and significantly increase the phosphorylation (Tyr 15) of CDC2 leading to inactivation of CDC2.	Tyrosine	120-123	cyclin dependent kinase 1	Homo sapiens	131-135
27123550-5	2016	DPD could also induce the cell cycle arrest at G2/M phase in HeLa cells and significantly increase the phosphorylation (Tyr 15) of CDC2 leading to inactivation of CDC2.	Tyrosine	120-123	cyclin dependent kinase 1	Homo sapiens	163-167
26986084-5	2016	Cantharidin treatment in the HCSCs for 48 h increased expression of histone H2AX, Myt1, cyclin A2, cyclin B1, p53 and cdc2 (Tyr15) phosphorylation significantly compared to the parental cells.	Cantharidin	0-11	cyclin dependent kinase 1	Homo sapiens	118-122
26508031-10	2016	Moreover, esculetin increased the percentage of cells in G2/M phase and regulated the expressions of p53, p21, CDK1, and cyclin B1.	esculetin	10-19	cyclin dependent kinase 1	Homo sapiens	111-115
26846469-7	2016	The results indicated that Dp treatment significantly inhibited cell proliferation in a dose- and time-dependent manner, and blocked cell cycle progression at the G1/S phase in the U87MG and T98G cells via the upregulation of p53 and p21 protein expression, and simultaneous downregulation of Cdc25A, Cdc2 and P-Cdc2 protein expression.	dracorhodin	27-29	cyclin dependent kinase 1	Homo sapiens	293-297
26846469-7	2016	The results indicated that Dp treatment significantly inhibited cell proliferation in a dose- and time-dependent manner, and blocked cell cycle progression at the G1/S phase in the U87MG and T98G cells via the upregulation of p53 and p21 protein expression, and simultaneous downregulation of Cdc25A, Cdc2 and P-Cdc2 protein expression.	dracorhodin	27-29	cyclin dependent kinase 1	Homo sapiens	301-305
27035875-4	2016	By immunofluorescence staining, subcellular fractionation and western blotting, the present study demonstrated that curcumin was able to induce G2/M cell cycle arrest and apoptosis by increasing the expression levels of cyclin G2, cleaved caspase-3 and Fas ligand (FasL), and decreasing the expression of cyclin-dependent kinase 1 (CDK1).	Curcumin	116-124	cyclin dependent kinase 1	Homo sapiens	305-330
27035875-4	2016	By immunofluorescence staining, subcellular fractionation and western blotting, the present study demonstrated that curcumin was able to induce G2/M cell cycle arrest and apoptosis by increasing the expression levels of cyclin G2, cleaved caspase-3 and Fas ligand (FasL), and decreasing the expression of cyclin-dependent kinase 1 (CDK1).	Curcumin	116-124	cyclin dependent kinase 1	Homo sapiens	332-336
27035875-7	2016	Furthermore, following knockdown of FoxO1 expression in curcumin-treated U87 cells using FoxO1 small interfering RNA, the expression levels of cyclin G2, cleaved caspase-3 and FasL were inhibited; however, the expression levels of CDK1 were not markedly altered.	Curcumin	56-64	cyclin dependent kinase 1	Homo sapiens	231-235
27186148-3	2016	Midostaurin is a Type III receptor tyrosine kinase inhibitor found to inhibit FLT3 and other receptor tyrosine kinases, including platelet-derived growth factor receptors, cyclin-dependent kinase 1, src, c-kit, and vascular endothelial growth factor receptor.	midostaurin	0-11	cyclin dependent kinase 1	Homo sapiens	172-197
26801641-4	2016	Fun30 is phosphorylated by Cdk1 on Serine 28 to stimulate its functions in DNA damage response including resection of DSB ends.	Serine	35-41	cyclin dependent kinase 1	Homo sapiens	27-31
27030108-2	2016	Here we show that Aurora B and CDK1 phosphorylate microtubule end-binding protein 2 (EB2) at multiple sites within the amino terminus and a cluster of serine/threonine residues in the linker connecting the calponin homology and end-binding homology domains.	Serine	151-157	cyclin dependent kinase 1	Homo sapiens	31-35
27087371-5	2016	The expressions of ATM, Chk1, Chk2, phosphorylated Cdc2 and CDK2 were up-regulated in the MGC-803 cells after Jaridonin treatment, while the levels of Cdc2 and CDK2 were decreased.	jaridonin	110-119	cyclin dependent kinase 1	Homo sapiens	51-55
27087371-5	2016	The expressions of ATM, Chk1, Chk2, phosphorylated Cdc2 and CDK2 were up-regulated in the MGC-803 cells after Jaridonin treatment, while the levels of Cdc2 and CDK2 were decreased.	jaridonin	110-119	cyclin dependent kinase 1	Homo sapiens	151-155
27043646-10	2016	RESULTS: Cultures maintained in the presence of ethanol demonstrated a G2/M cell cycle arrest that was associated with a reduction in DNA content and increased levels of p-Cdc2 and p21, compared with cells cultured in its absence.	Ethanol	48-55	cyclin dependent kinase 1	Homo sapiens	172-176
27043646-12	2016	Additionally, culturing the cells in the presence of acetaldehyde alone resulted in increased levels of p-Cdc2 and p21.	Acetaldehyde	53-65	cyclin dependent kinase 1	Homo sapiens	106-110
27043646-13	2016	CONCLUSIONS: Acetaldehyde produced during ethanol oxidation has a major role in the ethanol metabolism-mediated G2/M cell cycle arrest, and the concurrent accumulation of p21 and p-Cdc2.	Acetaldehyde	13-25	cyclin dependent kinase 1	Homo sapiens	181-185
27043646-13	2016	CONCLUSIONS: Acetaldehyde produced during ethanol oxidation has a major role in the ethanol metabolism-mediated G2/M cell cycle arrest, and the concurrent accumulation of p21 and p-Cdc2.	Ethanol	42-49	cyclin dependent kinase 1	Homo sapiens	181-185
27030108-2	2016	Here we show that Aurora B and CDK1 phosphorylate microtubule end-binding protein 2 (EB2) at multiple sites within the amino terminus and a cluster of serine/threonine residues in the linker connecting the calponin homology and end-binding homology domains.	Threonine	158-167	cyclin dependent kinase 1	Homo sapiens	31-35
27031247-9	2016	Pre-treatment with AZD2014 in irradiated oral cancer cells induced tumor cell cycle arrest at the G1 and G2/M phases, which led to disruption of cyclin D1-CDK4 and cyclin B1-CDC2 complexes.	vistusertib	19-26	cyclin dependent kinase 1	Homo sapiens	174-178
27051274-7	2016	AZD1080 also significantly downregulated GSK-3beta, CDK2, CDK1, cyclin D1, MMP9, and Bcl-xL expression at both mRNA and protein levels.	2-hydroxy-3-(5-((morpholin-4-yl)methyl)pyridin-2-yl)-1H-indole-5-carbonitrile	0-7	cyclin dependent kinase 1	Homo sapiens	58-62
27028622-12	2016	While nicotine treatment increased the expression of phosphorylated cdc2 and histone H3, a marker of G2/M phase arrest, hexamethonium and Bay 11-7082 pretreatment reduced their expression.	Nicotine	6-14	cyclin dependent kinase 1	Homo sapiens	68-72
27028622-12	2016	While nicotine treatment increased the expression of phosphorylated cdc2 and histone H3, a marker of G2/M phase arrest, hexamethonium and Bay 11-7082 pretreatment reduced their expression.	Hexamethonium	120-133	cyclin dependent kinase 1	Homo sapiens	68-72
27028622-12	2016	While nicotine treatment increased the expression of phosphorylated cdc2 and histone H3, a marker of G2/M phase arrest, hexamethonium and Bay 11-7082 pretreatment reduced their expression.	3-(4-methylphenylsulfonyl)-2-propenenitrile	138-149	cyclin dependent kinase 1	Homo sapiens	68-72
26046302-6	2016	Mechanistically, BI 2536/VCR co-treatment triggers prolonged mitotic arrest, which is necessary for BI 2536/VCR-mediated apoptosis, since pharmacological inhibition of mitotic arrest by the CDK1 inhibitor RO-3306 significantly reduces cell death.	RO 3306	205-212	cyclin dependent kinase 1	Homo sapiens	190-194
26809061-3	2016	Nickel(II)-induced G2/M arrest was associated with up-regulation of p21(WAF1/CIP1) expression, decrease in phosphorylation at Thr(161) of Cdc2, and down-regulation of cyclin B1.	Nickel	0-6	cyclin dependent kinase 1	Homo sapiens	138-142
26409447-6	2016	Examination of the cell cycle analysis showed that resveratrol treatment induced cell cycle arrest in the G2/M phase and enhanced the expression of phospho-cdc2 (Tyr 15), cyclin A2, and cyclin B1 in the oral squamous cell carcinoma (OSCC) cells.	Resveratrol	51-62	cyclin dependent kinase 1	Homo sapiens	156-160
26409447-6	2016	Examination of the cell cycle analysis showed that resveratrol treatment induced cell cycle arrest in the G2/M phase and enhanced the expression of phospho-cdc2 (Tyr 15), cyclin A2, and cyclin B1 in the oral squamous cell carcinoma (OSCC) cells.	Tyrosine	162-165	cyclin dependent kinase 1	Homo sapiens	156-160
26796279-7	2016	The results indicated that curcumin induced cell cycle arrest at G2/M phase by downregulation of cyclin B1 and Cdc2 and inhibited colony formation in MCF-7wt cells.	Curcumin	27-35	cyclin dependent kinase 1	Homo sapiens	111-115
26881434-4	2016	This established that the KRAS/CDK1 synthetic lethality applies in tumour cells with either amino acid position 12 (p.G12V, pG12D, p.G12S) or amino acid position 13 (p.G13D) KRAS mutations and can also be replicated in vivo in a xenograft model using a small molecule CDK1 inhibitor.	pg12d	124-129	cyclin dependent kinase 1	Homo sapiens	31-35
26506538-8	2016	Besides, MC-LR also led to hyperphosphorylation of c-Myc, c-Jun, Bcl-2 and Bad and activation of Cdk1.	cyanoginosin LR	9-14	cyclin dependent kinase 1	Homo sapiens	97-101
26699757-3	2016	Exposure of J/Neo cells to kaempeferol caused cytotoxicity and activation of the ATM/ATR-Chk1/Chk2 pathway, activating the phosphorylation of p53 (Ser-15), inhibitory phosphorylation of Cdc25C (Ser-216), and inactivation of cyclin-dependent kinase 1 (Cdk1), with resultant G2- arrest of the cell cycle.	kaempeferol	27-38	cyclin dependent kinase 1	Homo sapiens	224-249
26699757-3	2016	Exposure of J/Neo cells to kaempeferol caused cytotoxicity and activation of the ATM/ATR-Chk1/Chk2 pathway, activating the phosphorylation of p53 (Ser-15), inhibitory phosphorylation of Cdc25C (Ser-216), and inactivation of cyclin-dependent kinase 1 (Cdk1), with resultant G2- arrest of the cell cycle.	kaempeferol	27-38	cyclin dependent kinase 1	Homo sapiens	251-255
26718904-7	2016	Isoalantolactone induced cell cycle arrest at G2/M phase and decreased the expression of cell cycle-related proteins cyclin B1 and CDK1 in SKOV3 cells.	isoalantolactone	0-16	cyclin dependent kinase 1	Homo sapiens	131-135
26411959-6	2016	BA-j is a selective CDK1 inhibitor, and has broad-spectrum anti-proliferative activity in human cancer cells (IC50 12.3muM).	ba-j	0-4	cyclin dependent kinase 1	Homo sapiens	20-24
26177583-7	2016	Mutating the Cdk1 consensus site S21 to alanine eliminates many of the phosphorylated species suggesting that S21 is a key site of phosphorylation in vivo.	Alanine	40-47	cyclin dependent kinase 1	Homo sapiens	13-17
26677104-13	2016	The present study demonstrated that chelidonine induces M phase arrest and mitotic slippage of SGC-7901 human gastric carcinoma cells via downregulating the expression of BubR1, Cdk1 and cyclin B1 proteins.	chelidonine	36-47	cyclin dependent kinase 1	Homo sapiens	178-182
27551490-7	2016	DBME induced G2/M phase arrest and apoptosis in MCF-7 cells by suppressing the expression of cyclin A1, cyclin B1 and Cdk-1 and increasing the expression of p53, Bax/Bcl-2 ratio leading to activation of caspases and PARP degradation.	dbme	0-4	cyclin dependent kinase 1	Homo sapiens	118-123
26759603-10	2016	In MCF-7 cells, ADHC-AXpn induced G2/M cell cycle arrest by mediating cyclin-B1, and CDK1 and its phosphorylation; and induced apoptosis through the mitochondrial-mediated apoptotic pathway, with inhibition of Akt activation.	axpn	21-25	cyclin dependent kinase 1	Homo sapiens	85-89
27771926-2	2016	Flavopiridol arrests cell cycle progression in the G1 or G2 phase by inhibiting the kinase activities of CDK1, CDK2, CDK4/6, and CDK7.	alvocidib	0-12	cyclin dependent kinase 1	Homo sapiens	105-109
27109154-7	2016	The induced G2/M phase arrest indicated by the Western blotting assay showed that casticin promoted the expression of p53, p21 and CHK-1 proteins and inhibited the protein levels of Cdc25c, CDK-1, Cyclin A and B.	casticin	82-90	cyclin dependent kinase 1	Homo sapiens	190-195
26411959-2	2016	Natural flavones are selective CDK1 inhibitors which can suppress the proliferation of cancer cells.	Flavones	8-16	cyclin dependent kinase 1	Homo sapiens	31-35
26129652-3	2016	Here we show that RA acts cell intrinsically in developing gut-tropic pre-mucosal dendritic cell (pre-muDC) to effect the differentiation and drive the specialization of intestinal CD103(+)CD11b(-) (cDC1) and of CD103(+)CD11b(+) (cDC2).	Tretinoin	18-20	cyclin dependent kinase 1	Homo sapiens	230-234
26483157-8	2016	Using phosphospecific antibodies, we confirm that two sites, serine 190 and serine 1176, are phosphorylated during mitosis in a Cdk1-dependent manner.	Serine	61-67	cyclin dependent kinase 1	Homo sapiens	128-132
26483157-8	2016	Using phosphospecific antibodies, we confirm that two sites, serine 190 and serine 1176, are phosphorylated during mitosis in a Cdk1-dependent manner.	Serine	76-82	cyclin dependent kinase 1	Homo sapiens	128-132
27832629-9	2016	Co-immunoprecipitation further confirmed that there was an interaction between p-ERK1/2 and cyclin D1, CDK4, cyclin B1, or CDK1, which was blunted in the presence of melatonin or PD98059.	Melatonin	166-175	cyclin dependent kinase 1	Homo sapiens	123-127
27832629-9	2016	Co-immunoprecipitation further confirmed that there was an interaction between p-ERK1/2 and cyclin D1, CDK4, cyclin B1, or CDK1, which was blunted in the presence of melatonin or PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	179-186	cyclin dependent kinase 1	Homo sapiens	123-127
26442630-7	2016	Interestingly, ATM/ATR activation by curcumin induced phosphorylation of Chk2 (Thr68) followed by that of Cdc25C (Ser216) and Cdc2 (Tyr15), and Cyclin B1 accumulation.	Curcumin	37-45	cyclin dependent kinase 1	Homo sapiens	106-110
26632330-0	2016	Block of CDK1-dependent polyadenosine elongation of Cyclin B mRNA in metaphase-i-arrested starfish oocytes is released by intracellular pH elevation upon spawning.	polyadenosine	24-37	cyclin dependent kinase 1	Homo sapiens	9-13
27744448-7	2016	3"-da can significantly improve the rate of small oocyte maturation in vitro and inhibits Cdc2 polyadenylation.	cordycepin	0-5	cyclin dependent kinase 1	Homo sapiens	90-94
26442630-9	2016	These results collectively show that curcumin treatment induced the DNA damage response via triggering an ATM-activated Chk2-Cdc25C-Cdc2 signaling pathway.	Curcumin	37-45	cyclin dependent kinase 1	Homo sapiens	125-129
26129652-4	2016	Systemic deficiency or DC-restricted antagonism of RA signaling resulted in altered phenotypes of intestinal cDC1 and cDC2, and reduced numbers of cDC2.	Tretinoin	51-53	cyclin dependent kinase 1	Homo sapiens	118-122
26129652-4	2016	Systemic deficiency or DC-restricted antagonism of RA signaling resulted in altered phenotypes of intestinal cDC1 and cDC2, and reduced numbers of cDC2.	Tretinoin	51-53	cyclin dependent kinase 1	Homo sapiens	147-151
26549230-5	2015	Interestingly, treatment with purvalanol A, a Cdk1 inhibitor, nearly completely blocked the dissociation of Cep169 from centrosomes during mitosis.	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	30-42	cyclin dependent kinase 1	Homo sapiens	46-50
26849623-4	2016	Western blot demonstrated that DYC-279-induced G2/M arrest effect was correlated with the inhibition of cyclin-dependent kinase 1 activity, including a concomitant downregulation of cyclinD1 and cdc2 and upregulation of cyclinB1 in HepG2 cells.	DYC-279	31-38	cyclin dependent kinase 1	Homo sapiens	104-129
26849623-4	2016	Western blot demonstrated that DYC-279-induced G2/M arrest effect was correlated with the inhibition of cyclin-dependent kinase 1 activity, including a concomitant downregulation of cyclinD1 and cdc2 and upregulation of cyclinB1 in HepG2 cells.	DYC-279	31-38	cyclin dependent kinase 1	Homo sapiens	195-199
26714015-5	2015	Frequency analysis of these phosphosites revealed a proline-rich motif signature downstream of BGLF4, indicating a broader substrate recognition for BGLF4 than its cellular ortholog cyclin-dependent kinase 1 (CDK1).	Proline	52-59	cyclin dependent kinase 1	Homo sapiens	182-207
26455550-4	2015	In addition, myricetin exerts antimitotic effects by targeting the overexpression of cyclin-dependent kinase 1 (CDK1) in liver cancer.	myricetin	13-22	cyclin dependent kinase 1	Homo sapiens	85-110
26670043-4	2015	Here, we report a dynamic enhancement of oxygen consumption and mitochondrial ATP generation in irradiated normal cells, paralleled with increased mitochondrial relocation of the cell-cycle kinase CDK1 and nuclear DNA repair.	Oxygen	41-47	cyclin dependent kinase 1	Homo sapiens	197-201
26670043-5	2015	The basal and radiation-induced mitochondrial ATP generation is reduced significantly in cells harboring CDK1 phosphorylation-deficient mutant complex I subunits.	Adenosine Triphosphate	46-49	cyclin dependent kinase 1	Homo sapiens	105-109
26670043-6	2015	Similarly, mitochondrial ATP generation and nuclear DNA repair are also compromised severely in cells harboring mitochondrially targeted, kinase-deficient CDK1.	Adenosine Triphosphate	25-28	cyclin dependent kinase 1	Homo sapiens	155-159
26304716-4	2015	Mechanistically, metformin caused abrogation of the G2 checkpoint and increase of mitotic catastrophe, associated with suppression of Wee1 kinase and in turn CDK1 Tyr15 phosphorylation.	Metformin	17-26	cyclin dependent kinase 1	Homo sapiens	158-162
26377911-5	2015	Further study proved that LG308 induced mitotic phase arrest and inhibited G2/M progression significantly in LNCaP and PC-3M cell lines in a dose-dependent manner, and these were associated with the upregulation of cyclin B1 and mitotic marker MPM-2 and the dephosphorylation of cdc2.	LG308	26-31	cyclin dependent kinase 1	Homo sapiens	279-283
26442525-0	2015	Restoration of paclitaxel resistance by CDK1 intervention in drug-resistant ovarian cancer.	Paclitaxel	15-25	cyclin dependent kinase 1	Homo sapiens	40-44
26442525-4	2015	Cyclin-dependent kinase 1 (CDK1) was found to be a potential target of transcription factors to regulate paclitaxel resistance.	Paclitaxel	105-115	cyclin dependent kinase 1	Homo sapiens	0-25
26442525-4	2015	Cyclin-dependent kinase 1 (CDK1) was found to be a potential target of transcription factors to regulate paclitaxel resistance.	Paclitaxel	105-115	cyclin dependent kinase 1	Homo sapiens	27-31
26442525-5	2015	As a result of the subsequent pharmacogenomics analysis, CDK1 inhibitor alsterpaullone was also indicated as a promising chemical that may be used in combinatorial therapies to reverse paclitaxel-induced chemoresistance.	alsterpaullone	72-86	cyclin dependent kinase 1	Homo sapiens	57-61
26442525-5	2015	As a result of the subsequent pharmacogenomics analysis, CDK1 inhibitor alsterpaullone was also indicated as a promising chemical that may be used in combinatorial therapies to reverse paclitaxel-induced chemoresistance.	Paclitaxel	185-195	cyclin dependent kinase 1	Homo sapiens	57-61
26442525-6	2015	Although a CDK1 inhibitor has the potential to kill cancer cells, short-term treatment over 2 weeks at sublethal doses effectively induced cell death only upon additional treatment with paclitaxel.	Paclitaxel	186-196	cyclin dependent kinase 1	Homo sapiens	11-15
26442525-8	2015	Thus, we suggest that inhibition of CDK1 with alsterpaullone may be a novel therapeutic method to reverse paclitaxel-induced resistance in ovarian cancer cells.	alsterpaullone	46-60	cyclin dependent kinase 1	Homo sapiens	36-40
26442525-8	2015	Thus, we suggest that inhibition of CDK1 with alsterpaullone may be a novel therapeutic method to reverse paclitaxel-induced resistance in ovarian cancer cells.	Paclitaxel	106-116	cyclin dependent kinase 1	Homo sapiens	36-40
26455550-4	2015	In addition, myricetin exerts antimitotic effects by targeting the overexpression of cyclin-dependent kinase 1 (CDK1) in liver cancer.	myricetin	13-22	cyclin dependent kinase 1	Homo sapiens	112-116
26341616-12	2015	Tryptanthrin resulted in a cell cycle arrest and dose-dependently decreased the expressions of cyclin A, cyclin B, cyclin dependent kinase(CDK) 1 and 2, but not cyclin D and cyclin E, at both the mRNA and protein levels.	tryptanthrine	0-12	cyclin dependent kinase 1	Homo sapiens	115-151
26645158-11	2015	The Wee-1 inhibitor, MK-1775 restored the mitotic ratio and suppressed Cdk1 phosphorylation.	adavosertib	21-28	cyclin dependent kinase 1	Homo sapiens	71-75
26555773-0	2015	Diacerein retards cell growth of chondrosarcoma cells at the G2/M cell cycle checkpoint via cyclin B1/CDK1 and CDK2 downregulation.	diacerein	0-9	cyclin dependent kinase 1	Homo sapiens	102-106
26555773-10	2015	mRNA and protein analysis revealed that diacerein induced a down-regulation of the cyclin B1-CDK1 complex and a reduction in CDK2 expression.	diacerein	40-49	cyclin dependent kinase 1	Homo sapiens	93-97
26555773-14	2015	CONCLUSIONS: Our results demonstrate for the first time that the SYSADOA diacerein decreased the viability of human chondrosarcoma cells and induces G2/M cell cycle arrest by CDK1/cyclin B1 down-regulation.	diacerein	73-82	cyclin dependent kinase 1	Homo sapiens	175-179
26491887-5	2015	We confirmed that ouabain induced chromosome segregation disorder and S-cell cycle block by decreasing the expression of AURKA, SMC2, Cyclin D, and p-CDK1 as well as increasing the expression of p53.	Ouabain	18-25	cyclin dependent kinase 1	Homo sapiens	150-154
26556339-10	2015	Additionally, this phosphorylation is partially reversed by roscovitine treatment, implying cycling-dependent kinase 1 (CDK1) might be one of the upstream kinases.	Roscovitine	60-71	cyclin dependent kinase 1	Homo sapiens	92-118
26556339-10	2015	Additionally, this phosphorylation is partially reversed by roscovitine treatment, implying cycling-dependent kinase 1 (CDK1) might be one of the upstream kinases.	Roscovitine	60-71	cyclin dependent kinase 1	Homo sapiens	120-124
26415552-2	2015	Treating prostate cancer cells with physapubescin B resulted in the accumulation of cells in the G2/M phase, which was associated with reduced Cdc25C levels and increased levels of CyclinB1, P21 as well as p-Cdk1 (Tyr15).	physapubescin B	36-51	cyclin dependent kinase 1	Homo sapiens	208-212
26352374-8	2015	RESULTS: Exposure to 6 h of 20 mug/ml propofol increased cell death from 3.18 +- 0.17% in the control-treated group to 9.6 +- 0.95% and led to detrimental increases in mitochondrial fission (n = 5 coverslips per group) accompanied by increased expression of activated dynamin-related protein 1 and cyclin-dependent kinase 1, key proteins responsible for mitochondrial fission.	Propofol	38-46	cyclin dependent kinase 1	Homo sapiens	298-323
26411703-0	2015	Inhibition of cyclin-dependent kinase CDK1 by oxindolimine ligands and corresponding copper and zinc complexes.	3-aminoindol-2-one	46-58	cyclin dependent kinase 1	Homo sapiens	38-42
26246051-7	2015	Second, paclitaxel but not zerumbone induced Cdk1 activity.	Paclitaxel	8-18	cyclin dependent kinase 1	Homo sapiens	45-49
26445453-7	2015	Exposure to crizotinib impaired cell growth, and accumulation at G2/M phase was attributed to an altered expression and activation of checkpoint regulators, such as Cyclin B1 and Cdc2.	Crizotinib	12-22	cyclin dependent kinase 1	Homo sapiens	179-183
26411703-0	2015	Inhibition of cyclin-dependent kinase CDK1 by oxindolimine ligands and corresponding copper and zinc complexes.	Copper	85-91	cyclin dependent kinase 1	Homo sapiens	38-42
26411703-1	2015	Oxindolimine-copper(II) and zinc(II) complexes that previously have shown to induce apoptosis, with DNA and mitochondria as main targets, exhibit here significant inhibition of kinase CDK1/cyclin B protein.	3-aminoindol-2-one	0-12	cyclin dependent kinase 1	Homo sapiens	184-188
26351876-5	2015	Furthermore, G-TPP induced G2-M phase cell cycle arrest by reducing the interaction between CDK1 and cyclin B1.	UNII-M6LC47TUG3	13-18	cyclin dependent kinase 1	Homo sapiens	92-96
26351876-6	2015	Additionally, reactive oxygen species (ROS) played a pivotal role in G-TPP-induced cell death and mitochondrial elongation in Hep3B cells, and these processes are mediated by the reduced association of CDK1 with cyclin B1 and the suppressed phosphorylation of Drp1 (Ser616).	Reactive Oxygen Species	14-37	cyclin dependent kinase 1	Homo sapiens	202-206
26351876-6	2015	Additionally, reactive oxygen species (ROS) played a pivotal role in G-TPP-induced cell death and mitochondrial elongation in Hep3B cells, and these processes are mediated by the reduced association of CDK1 with cyclin B1 and the suppressed phosphorylation of Drp1 (Ser616).	Reactive Oxygen Species	39-42	cyclin dependent kinase 1	Homo sapiens	202-206
26351876-6	2015	Additionally, reactive oxygen species (ROS) played a pivotal role in G-TPP-induced cell death and mitochondrial elongation in Hep3B cells, and these processes are mediated by the reduced association of CDK1 with cyclin B1 and the suppressed phosphorylation of Drp1 (Ser616).	UNII-M6LC47TUG3	69-74	cyclin dependent kinase 1	Homo sapiens	202-206
26485758-4	2015	Here, we reported that arenobufagin blocked the transition from G2 to M phase of cell cycle through inhibiting the activation of CDK1-Cyclin B1 complex; The tumor suppressor p53 contributed to sustaining arrest at the G2 phase of the cell cycle in hepatocellular carcinoma (HCC) cells.	arenobufagin	23-35	cyclin dependent kinase 1	Homo sapiens	129-133
26216057-3	2015	Chk1 blocks mitosis by maintaining high levels of inhibitory tyrosine phosphorylation of the mitotic cyclin-dependent kinase 1; however, the mechanisms that underlie replication fork stabilization and suppression of origin firing are less well defined.	Tyrosine	61-69	cyclin dependent kinase 1	Homo sapiens	101-126
26228523-7	2015	It was revealed that D-homoestrone-treated HeLa cells are not able to enter mitosis because the cyclin-dependent kinase 1-cyclin B complex loses its activity, resulting in the decreased inactivation of stathmin and a concomitant disturbance of microtubule formation.	D-homoestrone	21-34	cyclin dependent kinase 1	Homo sapiens	96-121
26411703-1	2015	Oxindolimine-copper(II) and zinc(II) complexes that previously have shown to induce apoptosis, with DNA and mitochondria as main targets, exhibit here significant inhibition of kinase CDK1/cyclin B protein.	cupric ion	13-23	cyclin dependent kinase 1	Homo sapiens	184-188
26411703-1	2015	Oxindolimine-copper(II) and zinc(II) complexes that previously have shown to induce apoptosis, with DNA and mitochondria as main targets, exhibit here significant inhibition of kinase CDK1/cyclin B protein.	Zinc	28-36	cyclin dependent kinase 1	Homo sapiens	184-188
26585231-5	2015	In all cells, AZD1775 caused inhibition of CDK1 phosphorylation and G2 checkpoint abrogation.	adavosertib	14-21	cyclin dependent kinase 1	Homo sapiens	43-47
26330167-0	2015	BA-j as a novel CDK1 inhibitor selectively induces apoptosis in cancer cells by regulating ROS.	ba-j	0-4	cyclin dependent kinase 1	Homo sapiens	16-20
26255837-8	2015	Additionally, they caused up-regulation of p53 and p21 and down-regulation of redox-sensitive Cdc25C along with cyclin B1/Cdk1 in a Michael acceptor- and ROS-dependent fashion.	Reactive Oxygen Species	154-157	cyclin dependent kinase 1	Homo sapiens	122-126
26330167-0	2015	BA-j as a novel CDK1 inhibitor selectively induces apoptosis in cancer cells by regulating ROS.	Reactive Oxygen Species	91-94	cyclin dependent kinase 1	Homo sapiens	16-20
26330167-2	2015	8-Hydroxypiperidinemethyl-baicalein (BA-j) is a novel selective CDK1 inhibitor with broad spectrum anti-cancer activity (IC50 12.3 muM) and 2 tumor xenografts.	8-hydroxypiperidinemethyl-baicalein	0-35	cyclin dependent kinase 1	Homo sapiens	64-68
26330167-2	2015	8-Hydroxypiperidinemethyl-baicalein (BA-j) is a novel selective CDK1 inhibitor with broad spectrum anti-cancer activity (IC50 12.3 muM) and 2 tumor xenografts.	ba-j	37-41	cyclin dependent kinase 1	Homo sapiens	64-68
25744022-5	2015	During AMCD-induced prolonged mitosis, Fcp1-dependent Wee1 reactivation lowered cdk1 activity, weakening SAC-dependent mitotic arrest and leading to mitosis exit and survival.	amcd	7-11	cyclin dependent kinase 1	Homo sapiens	80-84
25744022-7	2015	Thus, the Fcp1-Wee1-Cdk1 (FWC) axis affects SAC robustness and AMCDs sensitivity.	amcds	63-68	cyclin dependent kinase 1	Homo sapiens	20-24
25916210-4	2015	According to flow cytometric analysis, nimbolide treatment resulted in G2/M arrest in 786-O and A-498 cells accompanied with an increase in the phosphorylation status of p53, cdc2, cdc25c, and decreased expressions of cyclin A, cyclin B, cdc2, and cdc25c.	nimbolide	39-48	cyclin dependent kinase 1	Homo sapiens	175-179
25916210-4	2015	According to flow cytometric analysis, nimbolide treatment resulted in G2/M arrest in 786-O and A-498 cells accompanied with an increase in the phosphorylation status of p53, cdc2, cdc25c, and decreased expressions of cyclin A, cyclin B, cdc2, and cdc25c.	nimbolide	39-48	cyclin dependent kinase 1	Homo sapiens	181-185
25917079-7	2015	On molecular grounds, Eribulin/BI 2536 co-treatment causes profound mitotic arrest, which is critically required for synergism, since inhibition of mitotic arrest by CDK1 inhibitor RO-3306 abolishes Eribulin/BI 2536-mediated apoptosis.	RO 3306	181-188	cyclin dependent kinase 1	Homo sapiens	166-170
25917079-7	2015	On molecular grounds, Eribulin/BI 2536 co-treatment causes profound mitotic arrest, which is critically required for synergism, since inhibition of mitotic arrest by CDK1 inhibitor RO-3306 abolishes Eribulin/BI 2536-mediated apoptosis.	Bismuth	31-33	cyclin dependent kinase 1	Homo sapiens	166-170
25872745-6	2015	Accordingly, inhibition of ataxia telangiectasia mutated (ATM) by caffeine or siRNA abolished the increase in the p-Chk2 level and restored the delayed CDK1 kinase activity in ChangX cells.	Caffeine	66-74	cyclin dependent kinase 1	Homo sapiens	152-156
26349994-0	2015	Combination of HDAC inhibitor TSA and silibinin induces cell cycle arrest and apoptosis by targeting survivin and cyclinB1/Cdk1 in pancreatic cancer cells.	trichostatin A	30-33	cyclin dependent kinase 1	Homo sapiens	123-127
26349994-0	2015	Combination of HDAC inhibitor TSA and silibinin induces cell cycle arrest and apoptosis by targeting survivin and cyclinB1/Cdk1 in pancreatic cancer cells.	Silybin	38-47	cyclin dependent kinase 1	Homo sapiens	123-127
26349994-7	2015	Moreover, treatment with TSA and silibinin resulted in a profound reduction in the expression of cyclinA2, cyclinB1/Cdk1 and survivin.	trichostatin A	25-28	cyclin dependent kinase 1	Homo sapiens	116-120
26349994-7	2015	Moreover, treatment with TSA and silibinin resulted in a profound reduction in the expression of cyclinA2, cyclinB1/Cdk1 and survivin.	Silybin	33-42	cyclin dependent kinase 1	Homo sapiens	116-120
25947565-2	2015	CDK1/CDK2 inhibitors, such as dinaciclib, combined with anthracyclines, were synergistic in decreasing viability of TNBC cell lines.	dinaciclib	30-40	cyclin dependent kinase 1	Homo sapiens	0-4
25947565-2	2015	CDK1/CDK2 inhibitors, such as dinaciclib, combined with anthracyclines, were synergistic in decreasing viability of TNBC cell lines.	Anthracyclines	56-70	cyclin dependent kinase 1	Homo sapiens	0-4
25872745-5	2015	In these cells, inhibitory phosphorylation of Cdc25C phosphatase (Ser(216)) and CDK1 (Tyr(15)) was elevated; consequently, cell-cycle progression was delayed at G2/M phase, suggesting that activation of the ATM-Chk2 pathway by the HBV X protein (HBx) induces cell-cycle delay.	Tyrosine	86-89	cyclin dependent kinase 1	Homo sapiens	80-84
26287184-4	2015	Methyl sartortuoate treatment led to reduced expression of cdc2 and up-regulated p21 and p53, suggesting that Methyl sartortuoate induced G2-M arrest through modulation of p53/p21/cdc2 pathways.	methyl sartortuoate	0-19	cyclin dependent kinase 1	Homo sapiens	59-63
26287184-4	2015	Methyl sartortuoate treatment led to reduced expression of cdc2 and up-regulated p21 and p53, suggesting that Methyl sartortuoate induced G2-M arrest through modulation of p53/p21/cdc2 pathways.	methyl sartortuoate	0-19	cyclin dependent kinase 1	Homo sapiens	180-184
26287184-4	2015	Methyl sartortuoate treatment led to reduced expression of cdc2 and up-regulated p21 and p53, suggesting that Methyl sartortuoate induced G2-M arrest through modulation of p53/p21/cdc2 pathways.	methyl sartortuoate	110-129	cyclin dependent kinase 1	Homo sapiens	59-63
26287184-4	2015	Methyl sartortuoate treatment led to reduced expression of cdc2 and up-regulated p21 and p53, suggesting that Methyl sartortuoate induced G2-M arrest through modulation of p53/p21/cdc2 pathways.	methyl sartortuoate	110-129	cyclin dependent kinase 1	Homo sapiens	180-184
26029982-5	2015	In addition, the serine at position 22, a target for CDK1-dependent phosphorylation, was mutated to alanine, preventing CDK1-catalyzed nuclear envelope disassembly.	Serine	17-23	cyclin dependent kinase 1	Homo sapiens	53-57
26029982-5	2015	In addition, the serine at position 22, a target for CDK1-dependent phosphorylation, was mutated to alanine, preventing CDK1-catalyzed nuclear envelope disassembly.	Serine	17-23	cyclin dependent kinase 1	Homo sapiens	120-124
26029982-5	2015	In addition, the serine at position 22, a target for CDK1-dependent phosphorylation, was mutated to alanine, preventing CDK1-catalyzed nuclear envelope disassembly.	Alanine	100-107	cyclin dependent kinase 1	Homo sapiens	53-57
26029982-5	2015	In addition, the serine at position 22, a target for CDK1-dependent phosphorylation, was mutated to alanine, preventing CDK1-catalyzed nuclear envelope disassembly.	Alanine	100-107	cyclin dependent kinase 1	Homo sapiens	120-124
26053095-10	2015	Cantharidin and OA also up-regulated the expression of p21, an inhibitor of CDK1, via autophagy rather than PP2A/JNK pathway.	Cantharidin	0-11	cyclin dependent kinase 1	Homo sapiens	76-80
26396928-7	2015	Combination of AITC and cisplatin inhibits the expression of G2/M checkpoint-relevant proteins including CDC2, cyclin B1 and CDC25.	Cisplatin	24-33	cyclin dependent kinase 1	Homo sapiens	105-109
26131711-1	2015	The activity of Cdc2 (CDK1) kinase, which coordinates cell cycle progression and DNA break repair, is blocked upon its phosphorylation at tyrosine 15 (Y15) by Wee1 kinase in the presence of DNA damage.	Tyrosine	138-146	cyclin dependent kinase 1	Homo sapiens	22-26
26131711-3	2015	Human CDK1 is phosphorylated by Myt1 kinase at threonine 14 (T14) close to its ATP binding site before being modified at threonine 161 (T167Sp) in its T-loop by the CDK-activating kinase (CAK).	Threonine	47-56	cyclin dependent kinase 1	Homo sapiens	6-10
26131711-3	2015	Human CDK1 is phosphorylated by Myt1 kinase at threonine 14 (T14) close to its ATP binding site before being modified at threonine 161 (T167Sp) in its T-loop by the CDK-activating kinase (CAK).	Adenosine Triphosphate	79-82	cyclin dependent kinase 1	Homo sapiens	6-10
26131711-3	2015	Human CDK1 is phosphorylated by Myt1 kinase at threonine 14 (T14) close to its ATP binding site before being modified at threonine 161 (T167Sp) in its T-loop by the CDK-activating kinase (CAK).	Threonine	121-130	cyclin dependent kinase 1	Homo sapiens	6-10
26023773-1	2015	Mitotic repression of rRNA synthesis requires inactivation of the RNA polymerase I (Pol I)-specific transcription factor SL1 by Cdk1/cyclin B-dependent phosphorylation of TAF(I)110 (TBP-associated factor 110) at a single threonine residue (T852).	Threonine	221-230	cyclin dependent kinase 1	Homo sapiens	128-132
25962959-2	2015	Dinaciclib, a novel small molecule inhibitor of CDK1, CDK2, CDK5 and CDK9, is assessed in clinical trials for the treatment of several types of cancers.	dinaciclib	0-10	cyclin dependent kinase 1	Homo sapiens	48-52
25962959-4	2015	Dinaciclib alone actively induced cell growth inhibition, cell cycle arrest and apoptosis with the increased intracellular ROS levels, which were accompanied by obvious alterations of related proteins such as CDKs, Cyclins, Mcl-1, XIAP and survivin.	dinaciclib	0-10	cyclin dependent kinase 1	Homo sapiens	209-213
25388513-8	2015	Finally, we tested CDK1 inhibitor RO-3306, which impairs HR by inhibiting CDK1-mediated BRCA1 phosphorylation.	RO 3306	34-41	cyclin dependent kinase 1	Homo sapiens	19-23
25388513-8	2015	Finally, we tested CDK1 inhibitor RO-3306, which impairs HR by inhibiting CDK1-mediated BRCA1 phosphorylation.	RO 3306	34-41	cyclin dependent kinase 1	Homo sapiens	74-78
26207228-1	2015	Roscovitine [CY-202, (R)-Roscovitine, Seliciclib] is a small molecule that inhibits cyclin-dependent kinases (CDKs) through direct competition at the ATP-binding site.	Roscovitine	0-11	cyclin dependent kinase 1	Homo sapiens	110-114
26207228-1	2015	Roscovitine [CY-202, (R)-Roscovitine, Seliciclib] is a small molecule that inhibits cyclin-dependent kinases (CDKs) through direct competition at the ATP-binding site.	cy-202	13-19	cyclin dependent kinase 1	Homo sapiens	110-114
26207228-1	2015	Roscovitine [CY-202, (R)-Roscovitine, Seliciclib] is a small molecule that inhibits cyclin-dependent kinases (CDKs) through direct competition at the ATP-binding site.	Roscovitine	21-36	cyclin dependent kinase 1	Homo sapiens	110-114
26207228-1	2015	Roscovitine [CY-202, (R)-Roscovitine, Seliciclib] is a small molecule that inhibits cyclin-dependent kinases (CDKs) through direct competition at the ATP-binding site.	Roscovitine	38-48	cyclin dependent kinase 1	Homo sapiens	110-114
26207228-1	2015	Roscovitine [CY-202, (R)-Roscovitine, Seliciclib] is a small molecule that inhibits cyclin-dependent kinases (CDKs) through direct competition at the ATP-binding site.	Adenosine Triphosphate	150-153	cyclin dependent kinase 1	Homo sapiens	110-114
26207228-2	2015	It is a broad-range purine inhibitor, which inhibits CDK1, CDK2, CDK5 and CDK7, but is a poor inhibitor for CDK4 and CDK6.	purine	20-26	cyclin dependent kinase 1	Homo sapiens	53-57
26035463-6	2015	Downregulation of CCNB1 (cyclin B1) and CDC2 mRNA and upregulation of CDKN1A (p21) mRNA were in accord with miltirone-induced G2/M arrest.	miltirone	108-117	cyclin dependent kinase 1	Homo sapiens	40-44
25947085-0	2015	The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1.	2-arylnaphthyridin-4-one	22-46	cyclin dependent kinase 1	Homo sapiens	158-162
25947085-9	2015	The CDK1 inhibitor, roscovitine, reversed the CSC-3436-induced upregulation of CDK1 activity as well as the mitotic arrest.	Roscovitine	20-31	cyclin dependent kinase 1	Homo sapiens	4-8
25947085-9	2015	The CDK1 inhibitor, roscovitine, reversed the CSC-3436-induced upregulation of CDK1 activity as well as the mitotic arrest.	Roscovitine	20-31	cyclin dependent kinase 1	Homo sapiens	79-83
25947085-9	2015	The CDK1 inhibitor, roscovitine, reversed the CSC-3436-induced upregulation of CDK1 activity as well as the mitotic arrest.	csc-3436	46-54	cyclin dependent kinase 1	Homo sapiens	4-8
25947085-9	2015	The CDK1 inhibitor, roscovitine, reversed the CSC-3436-induced upregulation of CDK1 activity as well as the mitotic arrest.	csc-3436	46-54	cyclin dependent kinase 1	Homo sapiens	79-83
25994054-6	2015	Increased levels of cAMP and/or ROS trigger accumulation of Thr-14/Tyr-15 phosphorylated cyclin-dependent kinase 1 (Cdk1) on one hand and degradation of cyclin B1 through ubiquitin-mediated proteolysis on the other hand to destabilize maturation promoting factor (MPF).	Cyclic AMP	20-24	cyclin dependent kinase 1	Homo sapiens	89-114
25847232-2	2015	CyclinA2-CDK1/2 phosphorylates SAMHD1 at Thr-592, but how this modification controls SAMHD1 functions in proliferating cells is not known.	Threonine	41-44	cyclin dependent kinase 1	Homo sapiens	9-13
25994054-6	2015	Increased levels of cAMP and/or ROS trigger accumulation of Thr-14/Tyr-15 phosphorylated cyclin-dependent kinase 1 (Cdk1) on one hand and degradation of cyclin B1 through ubiquitin-mediated proteolysis on the other hand to destabilize maturation promoting factor (MPF).	Cyclic AMP	20-24	cyclin dependent kinase 1	Homo sapiens	116-120
25994054-6	2015	Increased levels of cAMP and/or ROS trigger accumulation of Thr-14/Tyr-15 phosphorylated cyclin-dependent kinase 1 (Cdk1) on one hand and degradation of cyclin B1 through ubiquitin-mediated proteolysis on the other hand to destabilize maturation promoting factor (MPF).	Reactive Oxygen Species	32-35	cyclin dependent kinase 1	Homo sapiens	89-114
25994054-6	2015	Increased levels of cAMP and/or ROS trigger accumulation of Thr-14/Tyr-15 phosphorylated cyclin-dependent kinase 1 (Cdk1) on one hand and degradation of cyclin B1 through ubiquitin-mediated proteolysis on the other hand to destabilize maturation promoting factor (MPF).	Reactive Oxygen Species	32-35	cyclin dependent kinase 1	Homo sapiens	116-120
25994054-6	2015	Increased levels of cAMP and/or ROS trigger accumulation of Thr-14/Tyr-15 phosphorylated cyclin-dependent kinase 1 (Cdk1) on one hand and degradation of cyclin B1 through ubiquitin-mediated proteolysis on the other hand to destabilize maturation promoting factor (MPF).	Threonine	60-63	cyclin dependent kinase 1	Homo sapiens	89-114
25994054-6	2015	Increased levels of cAMP and/or ROS trigger accumulation of Thr-14/Tyr-15 phosphorylated cyclin-dependent kinase 1 (Cdk1) on one hand and degradation of cyclin B1 through ubiquitin-mediated proteolysis on the other hand to destabilize maturation promoting factor (MPF).	Threonine	60-63	cyclin dependent kinase 1	Homo sapiens	116-120
25994054-6	2015	Increased levels of cAMP and/or ROS trigger accumulation of Thr-14/Tyr-15 phosphorylated cyclin-dependent kinase 1 (Cdk1) on one hand and degradation of cyclin B1 through ubiquitin-mediated proteolysis on the other hand to destabilize maturation promoting factor (MPF).	Tyrosine	67-70	cyclin dependent kinase 1	Homo sapiens	89-114
25994054-6	2015	Increased levels of cAMP and/or ROS trigger accumulation of Thr-14/Tyr-15 phosphorylated cyclin-dependent kinase 1 (Cdk1) on one hand and degradation of cyclin B1 through ubiquitin-mediated proteolysis on the other hand to destabilize maturation promoting factor (MPF).	Tyrosine	67-70	cyclin dependent kinase 1	Homo sapiens	116-120
25994202-5	2015	Chk1 inhibitors reduced TH-302-induced cell cycle arrest via blocking TH-302-induced decrease of phosphorylation of histone H3 and increasing Cdc2-Y15 phosphorylation.	TH 302	24-30	cyclin dependent kinase 1	Homo sapiens	142-146
25994202-5	2015	Chk1 inhibitors reduced TH-302-induced cell cycle arrest via blocking TH-302-induced decrease of phosphorylation of histone H3 and increasing Cdc2-Y15 phosphorylation.	TH 302	70-76	cyclin dependent kinase 1	Homo sapiens	142-146
25607114-5	2015	However, co-treatment with anti-VEGF significantly restored etoposide-induced cell apoptosis and cell cycle arrest, as indicated by the elimination of B-cell lymphoma 2 (Bcl-2), procaspase 3, cyclin B1 and Cdc2.	Etoposide	60-69	cyclin dependent kinase 1	Homo sapiens	206-210
25938491-7	2015	The pactamycin analogs induce expression of cell cycle regulatory proteins including master regulator p53, its downstream target p21Cip1/WAF1, p27kip21, p19, cyclin E, total and phospho Cdc2 (Tyr15) and Cdc25C.	Pactamycin	4-14	cyclin dependent kinase 1	Homo sapiens	186-190
26221255-9	2015	The expression of Cyclin B1, CDC2 and cdc25C were downregulated, however, the expression of p-CDC2 and p-cdc25c was significantly upregulated when the neuroglioma cells were exposed to honokiol.	honokiol	185-193	cyclin dependent kinase 1	Homo sapiens	29-33
26221255-9	2015	The expression of Cyclin B1, CDC2 and cdc25C were downregulated, however, the expression of p-CDC2 and p-cdc25c was significantly upregulated when the neuroglioma cells were exposed to honokiol.	honokiol	185-193	cyclin dependent kinase 1	Homo sapiens	94-98
25683911-2	2015	Treatment of p53 wild-type melanoma cells with the genotoxic agent doxorubicin induces G2-M arrest, inhibitory phosphorylation of cell cycle kinase Cdc2 (CDK1) and enhanced expression of p53/p21.	Doxorubicin	67-78	cyclin dependent kinase 1	Homo sapiens	148-152
25683911-2	2015	Treatment of p53 wild-type melanoma cells with the genotoxic agent doxorubicin induces G2-M arrest, inhibitory phosphorylation of cell cycle kinase Cdc2 (CDK1) and enhanced expression of p53/p21.	Doxorubicin	67-78	cyclin dependent kinase 1	Homo sapiens	154-158
25812484-3	2015	Exploring the growth-inhibitory mechanisms of 8-ADEQ, we found that it causes a cell cycle arrest at the G2/M phase by DNA flow cytometric analysis, which was accompanied by upregulation of cyclin B1 expression and cyclin-dependent protein kinase 1 (Cdk1) phosphorylation.	(E)-8-acetoxy-2-(2-(3,4-diacetoxyphenyl)ethenyl)quinazoline	46-52	cyclin dependent kinase 1	Homo sapiens	215-248
25812484-3	2015	Exploring the growth-inhibitory mechanisms of 8-ADEQ, we found that it causes a cell cycle arrest at the G2/M phase by DNA flow cytometric analysis, which was accompanied by upregulation of cyclin B1 expression and cyclin-dependent protein kinase 1 (Cdk1) phosphorylation.	(E)-8-acetoxy-2-(2-(3,4-diacetoxyphenyl)ethenyl)quinazoline	46-52	cyclin dependent kinase 1	Homo sapiens	250-254
25603287-2	2015	We demonstrate that Cdk1-cyclin B, the central mitotic kinase, is specific for the trans conformation, not cis, of synthetic, locked Ser-Pro 11-residue peptide substrates, using LC-MSMS detection and sequencing of phosphorylated products.	Serine	133-136	cyclin dependent kinase 1	Homo sapiens	20-24
25603287-2	2015	We demonstrate that Cdk1-cyclin B, the central mitotic kinase, is specific for the trans conformation, not cis, of synthetic, locked Ser-Pro 11-residue peptide substrates, using LC-MSMS detection and sequencing of phosphorylated products.	Proline	137-140	cyclin dependent kinase 1	Homo sapiens	20-24
26131123-8	2015	Moreover, Cyclin B1, CDC2 and cdc25C were downregulated, and the expression of p-CDC2 and p-cdc25c was significantly upregulated upon honokiol treatment.	honokiol	134-142	cyclin dependent kinase 1	Homo sapiens	21-25
25732194-3	2015	Under these conditions, Cdk1 phosphorylation at Thr-161 and dephosphorylation at Tyr-15, up-regulation of cyclin B1 expression, histone H1 phosphorylation, Cdc25C phosphorylation at Thr-48, Bcl-2 phosphorylation at Thr-56 and Ser-70, Mcl-1 phosphorylation at Ser-159/Thr-163, and Bim phosphorylation were detected irrespective of Bcl-2 overexpression.	Tyrosine	81-84	cyclin dependent kinase 1	Homo sapiens	24-28
25732194-3	2015	Under these conditions, Cdk1 phosphorylation at Thr-161 and dephosphorylation at Tyr-15, up-regulation of cyclin B1 expression, histone H1 phosphorylation, Cdc25C phosphorylation at Thr-48, Bcl-2 phosphorylation at Thr-56 and Ser-70, Mcl-1 phosphorylation at Ser-159/Thr-163, and Bim phosphorylation were detected irrespective of Bcl-2 overexpression.	Threonine	182-185	cyclin dependent kinase 1	Homo sapiens	24-28
25732194-3	2015	Under these conditions, Cdk1 phosphorylation at Thr-161 and dephosphorylation at Tyr-15, up-regulation of cyclin B1 expression, histone H1 phosphorylation, Cdc25C phosphorylation at Thr-48, Bcl-2 phosphorylation at Thr-56 and Ser-70, Mcl-1 phosphorylation at Ser-159/Thr-163, and Bim phosphorylation were detected irrespective of Bcl-2 overexpression.	Threonine	182-185	cyclin dependent kinase 1	Homo sapiens	24-28
25732194-3	2015	Under these conditions, Cdk1 phosphorylation at Thr-161 and dephosphorylation at Tyr-15, up-regulation of cyclin B1 expression, histone H1 phosphorylation, Cdc25C phosphorylation at Thr-48, Bcl-2 phosphorylation at Thr-56 and Ser-70, Mcl-1 phosphorylation at Ser-159/Thr-163, and Bim phosphorylation were detected irrespective of Bcl-2 overexpression.	Serine	226-229	cyclin dependent kinase 1	Homo sapiens	24-28
25732194-4	2015	Concomitant treatment of JT/Neo cells with 2-MeO-E2 and the G1/S blocking agent aphidicolin resulted in G1/S arrest and abrogation of all apoptotic events, including Cdk1 activation, phosphorylation of Bcl-2, Mcl-1 and Bim, and ROS accumulation.	2-Methoxyestradiol	43-51	cyclin dependent kinase 1	Homo sapiens	166-170
25732194-4	2015	Concomitant treatment of JT/Neo cells with 2-MeO-E2 and the G1/S blocking agent aphidicolin resulted in G1/S arrest and abrogation of all apoptotic events, including Cdk1 activation, phosphorylation of Bcl-2, Mcl-1 and Bim, and ROS accumulation.	Aphidicolin	80-91	cyclin dependent kinase 1	Homo sapiens	166-170
25732194-5	2015	The 2-MeO-E2-induced phosphorylation of Bcl-2 family proteins and mitochondrial apoptotic events were suppressed by a Cdk1 inhibitor, but not by an Aurora A kinase (AURKA), Aurora B kinase (AURKB), JNK, or p38 MAPK inhibitor.	2-Methoxyestradiol	4-12	cyclin dependent kinase 1	Homo sapiens	118-122
25732194-8	2015	These results demonstrate that the apoptogenic effect of 2-MeO-E2 (0.5-1.0 muM) was attributable to mitotic spindle defect-mediated prometaphase arrest, Cdk1 activation, phosphorylation of Bcl-2, Mcl-1, and Bim, and activation of Bak and mitochondria-dependent caspase cascade.	2-Methoxyestradiol	57-65	cyclin dependent kinase 1	Homo sapiens	153-157
25732194-3	2015	Under these conditions, Cdk1 phosphorylation at Thr-161 and dephosphorylation at Tyr-15, up-regulation of cyclin B1 expression, histone H1 phosphorylation, Cdc25C phosphorylation at Thr-48, Bcl-2 phosphorylation at Thr-56 and Ser-70, Mcl-1 phosphorylation at Ser-159/Thr-163, and Bim phosphorylation were detected irrespective of Bcl-2 overexpression.	Threonine	48-51	cyclin dependent kinase 1	Homo sapiens	24-28
26131123-8	2015	Moreover, Cyclin B1, CDC2 and cdc25C were downregulated, and the expression of p-CDC2 and p-cdc25c was significantly upregulated upon honokiol treatment.	honokiol	134-142	cyclin dependent kinase 1	Homo sapiens	81-85
26131123-11	2015	CONCLUSIONS: These results confirmed that honokiol could induce apoptosis and cell cycle arrest, the underlying molecular mechanisms, at least partially, through activation p53 signaling and downregulation CDC2/cdc25C expression.	honokiol	42-50	cyclin dependent kinase 1	Homo sapiens	206-210
25864384-7	2015	We also describe the first structure of CDK1 bound to a potent ATP-competitive inhibitor and identify aspects of CDK1 structure and plasticity that might be exploited to develop CDK1-selective inhibitors.	Adenosine Triphosphate	63-66	cyclin dependent kinase 1	Homo sapiens	40-44
25691442-7	2015	Consistent with our flow cytometry data, IP-western blotting revealed an increase in S308 phosphorylation in G2/M, and the results of an in vitro kinase assay indicated that CDK1 was able to phosphorylate the AR on S308.	Sodium oxalate	85-89	cyclin dependent kinase 1	Homo sapiens	174-178
25691442-8	2015	Pharmacological inhibition of CDK1 activity resulted in decreased S308 phosphorylation in PCa cells.	Sodium oxalate	66-70	cyclin dependent kinase 1	Homo sapiens	30-34
25523151-0	2015	Phase I study of the novel Cdc2/CDK1 and AKT inhibitor terameprocol in patients with advanced leukemias.	terameprocol	55-67	cyclin dependent kinase 1	Homo sapiens	27-31
25523151-2	2015	Terameprocol is a small molecule survivin and Cdc2/CDK1 inhibitor that was studied in a Phase I dose-escalation trial.	terameprocol	0-12	cyclin dependent kinase 1	Homo sapiens	46-50
25523151-2	2015	Terameprocol is a small molecule survivin and Cdc2/CDK1 inhibitor that was studied in a Phase I dose-escalation trial.	terameprocol	0-12	cyclin dependent kinase 1	Homo sapiens	51-55
25651847-6	2015	Detailed signaling pathway analysis by western blot analysis revealed that low-dose oridonin treatment inhibited BxPC-3 cell proliferation by up-regulating p53 and down-regulating cyclin-dependent kinase 1 (CDK1), which led to cell cycle arrest in the G2/M phase.	oridonin	84-92	cyclin dependent kinase 1	Homo sapiens	180-205
25204801-5	2015	G-1 treatment also increased mitotic index concurrent with a decrease in phosphorylation of Cdk1 (Tyr 15) and an increase in phosphorylation of the mitotic checkpoint protein BuBR1.	Tyrosine	98-101	cyclin dependent kinase 1	Homo sapiens	92-96
25283841-2	2015	Here, we report that AZD1775 interacted synergistically with histone deacetylase inhibitors (HDACIs, for example, Vorinostat), which interrupt the DNA damage response, to kill p53-wild type (wt) or -deficient as well as FLT3-ITD leukemia cells in association with pronounced Wee1 inhibition and diminished cdc2/Cdk1 Y15 phosphorylation.	adavosertib	21-28	cyclin dependent kinase 1	Homo sapiens	306-310
25283841-2	2015	Here, we report that AZD1775 interacted synergistically with histone deacetylase inhibitors (HDACIs, for example, Vorinostat), which interrupt the DNA damage response, to kill p53-wild type (wt) or -deficient as well as FLT3-ITD leukemia cells in association with pronounced Wee1 inhibition and diminished cdc2/Cdk1 Y15 phosphorylation.	adavosertib	21-28	cyclin dependent kinase 1	Homo sapiens	311-315
25283841-2	2015	Here, we report that AZD1775 interacted synergistically with histone deacetylase inhibitors (HDACIs, for example, Vorinostat), which interrupt the DNA damage response, to kill p53-wild type (wt) or -deficient as well as FLT3-ITD leukemia cells in association with pronounced Wee1 inhibition and diminished cdc2/Cdk1 Y15 phosphorylation.	Vorinostat	114-124	cyclin dependent kinase 1	Homo sapiens	306-310
25283841-2	2015	Here, we report that AZD1775 interacted synergistically with histone deacetylase inhibitors (HDACIs, for example, Vorinostat), which interrupt the DNA damage response, to kill p53-wild type (wt) or -deficient as well as FLT3-ITD leukemia cells in association with pronounced Wee1 inhibition and diminished cdc2/Cdk1 Y15 phosphorylation.	Vorinostat	114-124	cyclin dependent kinase 1	Homo sapiens	311-315
25283841-4	2015	Although AZD1775 induced Chk1 activation, reflected by markedly increased Chk1 S296/S317/S345 phosphorylation leading to inhibitory T14 phosphorylation of cdc2/Cdk1, these compensatory responses were sharply abrogated by HDACIs.	adavosertib	9-16	cyclin dependent kinase 1	Homo sapiens	155-159
25283841-4	2015	Although AZD1775 induced Chk1 activation, reflected by markedly increased Chk1 S296/S317/S345 phosphorylation leading to inhibitory T14 phosphorylation of cdc2/Cdk1, these compensatory responses were sharply abrogated by HDACIs.	adavosertib	9-16	cyclin dependent kinase 1	Homo sapiens	160-164
25747583-7	2015	Mechanistically, SD-208-induced G2/M arrest was accompanied by an increase in levels of p21 in DU145 and PC3 cells as well as elevated phosphorylation of Cdc2 and Cdc25C in DU145 cells.	SD-208	17-23	cyclin dependent kinase 1	Homo sapiens	154-158
26045758-3	2015	We found that after treatment with PLGM, drug sensitivity and apoptosis rate of these drug resistance cancer cells were improved, cell cycle was arrested, the expressions of P-gp, MDR1, MRP1, Top-II, GST-pi, Survivin, Bcl-2, CDK1, ABCB1 and ABCG1 was decreased, while the activities of caspase-3/8 and intracellular content of Rh-123 was increased.	piperlonguminine	35-39	cyclin dependent kinase 1	Homo sapiens	225-229
25712646-7	2015	Additional studies indicated that DPT induced G2 arrest in U-87 MG cells by decreasing the expression of Cdc2, cyclin B1, and Cdc25C proteins.	deoxypodophyllotoxin	34-37	cyclin dependent kinase 1	Homo sapiens	105-109
25651847-6	2015	Detailed signaling pathway analysis by western blot analysis revealed that low-dose oridonin treatment inhibited BxPC-3 cell proliferation by up-regulating p53 and down-regulating cyclin-dependent kinase 1 (CDK1), which led to cell cycle arrest in the G2/M phase.	oridonin	84-92	cyclin dependent kinase 1	Homo sapiens	207-211
25625243-10	2015	In the cisplatin-treated susceptible cells, the levels of phosphorylated Cdc2 and Cdc25C were markedly decreased, leading to a loss of Cdc2 activity and G2/M arrest.	Cisplatin	7-16	cyclin dependent kinase 1	Homo sapiens	73-77
24488605-0	2015	Erratum to: The Contribution of Cdc2 in Rotenone-Induced G2/M Arrest and Caspase-3-Dependent Apoptosis.	Rotenone	40-48	cyclin dependent kinase 1	Homo sapiens	32-36
25639717-2	2015	Flow cytometric analysis and western blots of PA-1 cells treated with 40 micrometer CR389 revealed an appreciable cell cycle arrest at the G2/M phase through direct inhibition of the CDK1 complex.	cr389	84-89	cyclin dependent kinase 1	Homo sapiens	183-187
25625243-10	2015	In the cisplatin-treated susceptible cells, the levels of phosphorylated Cdc2 and Cdc25C were markedly decreased, leading to a loss of Cdc2 activity and G2/M arrest.	Cisplatin	7-16	cyclin dependent kinase 1	Homo sapiens	82-86
25625243-11	2015	In A549/CDDP cells, however, Cdc2 activity was supported by the expression of Cdc2 and Cdc25C after the addition of cisplatin, which resulted in G2/M progression.	Cisplatin	116-125	cyclin dependent kinase 1	Homo sapiens	29-33
25625243-11	2015	In A549/CDDP cells, however, Cdc2 activity was supported by the expression of Cdc2 and Cdc25C after the addition of cisplatin, which resulted in G2/M progression.	Cisplatin	116-125	cyclin dependent kinase 1	Homo sapiens	78-82
25625243-12	2015	SIGNIFICANCE: The resistance phenotype of G2/M progression has been correlated with dysregulation of Cdc2 in a human lung cancer cell line selected for cisplatin.	Cisplatin	152-161	cyclin dependent kinase 1	Homo sapiens	101-105
25541464-0	2015	Yeast as a model system to screen purine derivatives against human CDK1 and CDK2 kinases.	purine	34-40	cyclin dependent kinase 1	Homo sapiens	67-71
25541464-4	2015	In the present study, taking advantage of the fact that deletion of the yeast CDC28 gene is functionally complemented by human CDK1 or CDK2, we set up an in vivo screen system to evaluate the inhibitory potency of purine derivatives against these two human Cdks.	purine	214-220	cyclin dependent kinase 1	Homo sapiens	127-131
25604483-0	2015	Identification of non-Ser/Thr-Pro consensus motifs for Cdk1 and their roles in mitotic regulation of C2H2 zinc finger proteins and Ect2.	Serine	22-25	cyclin dependent kinase 1	Homo sapiens	55-59
25604483-0	2015	Identification of non-Ser/Thr-Pro consensus motifs for Cdk1 and their roles in mitotic regulation of C2H2 zinc finger proteins and Ect2.	Threonine	26-29	cyclin dependent kinase 1	Homo sapiens	55-59
25604483-0	2015	Identification of non-Ser/Thr-Pro consensus motifs for Cdk1 and their roles in mitotic regulation of C2H2 zinc finger proteins and Ect2.	Proline	30-33	cyclin dependent kinase 1	Homo sapiens	55-59
25604483-1	2015	The cyclin B-dependent protein kinase Cdk1 is a master regulator of mitosis and phosphorylates numerous proteins on the minimal consensus motif Ser/Thr-Pro (S/T-P).	Serine	144-147	cyclin dependent kinase 1	Homo sapiens	38-42
25604483-1	2015	The cyclin B-dependent protein kinase Cdk1 is a master regulator of mitosis and phosphorylates numerous proteins on the minimal consensus motif Ser/Thr-Pro (S/T-P).	Threonine	148-151	cyclin dependent kinase 1	Homo sapiens	38-42
25604483-1	2015	The cyclin B-dependent protein kinase Cdk1 is a master regulator of mitosis and phosphorylates numerous proteins on the minimal consensus motif Ser/Thr-Pro (S/T-P).	Proline	152-155	cyclin dependent kinase 1	Homo sapiens	38-42
25604483-4	2015	First, we show, by in vitro kinase assays, that previously identified non-S/T-P motifs all harbour one or more C-terminal Arg/Lys residues essential for their phosphorylation by Cdk1.	Arginine	122-125	cyclin dependent kinase 1	Homo sapiens	178-182
25604483-4	2015	First, we show, by in vitro kinase assays, that previously identified non-S/T-P motifs all harbour one or more C-terminal Arg/Lys residues essential for their phosphorylation by Cdk1.	Lysine	126-129	cyclin dependent kinase 1	Homo sapiens	178-182
25604483-5	2015	Second, using Arg/Lys-scanning oriented peptide libraries, we demonstrate that Cdk1 phosphorylates a minimal sequence S/T-X-X-R/K and more favorable sequences (P)-X-S/T-X-[R/K](2-5) as its non-S/T-P consensus motifs.	Arginine	14-17	cyclin dependent kinase 1	Homo sapiens	79-83
25608854-5	2015	In addition, DPT caused cyclin B1, Cdc2 and Cdc25C to accumulate, decreased the expression of Bcl-2 and activated caspase-3 and PARP, suggesting that caspase-mediated pathways were involved in DPT-induced apoptosis.	deoxypodophyllotoxin	13-16	cyclin dependent kinase 1	Homo sapiens	35-39
25604483-5	2015	Second, using Arg/Lys-scanning oriented peptide libraries, we demonstrate that Cdk1 phosphorylates a minimal sequence S/T-X-X-R/K and more favorable sequences (P)-X-S/T-X-[R/K](2-5) as its non-S/T-P consensus motifs.	Lysine	18-21	cyclin dependent kinase 1	Homo sapiens	79-83
25579846-4	2015	By using two mutually compatible, bioorthogonal reactions (copper-catalyzed azide-alkyne cycloaddition chemistry and TCO-tetrazine ligation), we demostrate small molecule-based multiplex bioimaging for simultaneous in situ monitoring of two important cell-cycle regulating kinases (AKA and CDK1).	Copper	59-65	cyclin dependent kinase 1	Homo sapiens	290-294
25395429-0	2015	Dinaciclib, a novel CDK inhibitor, demonstrates encouraging single-agent activity in patients with relapsed multiple myeloma.	dinaciclib	0-10	cyclin dependent kinase 1	Homo sapiens	20-23
25395429-2	2015	Dinaciclib is a novel potent small molecule inhibitor of cyclin-dependent kinases (CDK)1, CDK2, CDK5, and CDK9.	dinaciclib	0-10	cyclin dependent kinase 1	Homo sapiens	83-88
25450480-0	2015	Jaridonin-induced G2/M phase arrest in human esophageal cancer cells is caused by reactive oxygen species-dependent Cdc2-tyr15 phosphorylation via ATM-Chk1/2-Cdc25C pathway.	Reactive Oxygen Species	82-105	cyclin dependent kinase 1	Homo sapiens	116-120
25450480-3	2015	In this study, we found that the cell cycle arrest by Jaridonin was associated with the increased expression of phosphorylation of ATM at Ser1981 and Cdc2 at Tyr15.	jaridonin	54-63	cyclin dependent kinase 1	Homo sapiens	150-154
25445790-5	2015	Using quantitative label-based mass spectrometry, we find that FLNa serines 1084, 1459 and 1533 are phosphorylated in mitotic HeLa cells and all three sites match the phosphorylation consensus sequence of Cdk1.	Serine	68-75	cyclin dependent kinase 1	Homo sapiens	205-209
25450480-0	2015	Jaridonin-induced G2/M phase arrest in human esophageal cancer cells is caused by reactive oxygen species-dependent Cdc2-tyr15 phosphorylation via ATM-Chk1/2-Cdc25C pathway.	jaridonin	0-9	cyclin dependent kinase 1	Homo sapiens	116-120
25579846-4	2015	By using two mutually compatible, bioorthogonal reactions (copper-catalyzed azide-alkyne cycloaddition chemistry and TCO-tetrazine ligation), we demostrate small molecule-based multiplex bioimaging for simultaneous in situ monitoring of two important cell-cycle regulating kinases (AKA and CDK1).	Azides	76-81	cyclin dependent kinase 1	Homo sapiens	290-294
25579846-4	2015	By using two mutually compatible, bioorthogonal reactions (copper-catalyzed azide-alkyne cycloaddition chemistry and TCO-tetrazine ligation), we demostrate small molecule-based multiplex bioimaging for simultaneous in situ monitoring of two important cell-cycle regulating kinases (AKA and CDK1).	Alkynes	82-88	cyclin dependent kinase 1	Homo sapiens	290-294
25579846-4	2015	By using two mutually compatible, bioorthogonal reactions (copper-catalyzed azide-alkyne cycloaddition chemistry and TCO-tetrazine ligation), we demostrate small molecule-based multiplex bioimaging for simultaneous in situ monitoring of two important cell-cycle regulating kinases (AKA and CDK1).	1,2,3,4-tetrazine	121-130	cyclin dependent kinase 1	Homo sapiens	290-294
25980816-7	2015	ROS generated by estrogens affect pro-proliferative (e.g. cyclin D1, Cdc2), prosurvival (e.g. AKT), antiapoptotic (e.g. BCl2) and pro-inflammatory (e.g. NF-kappaB) molecules.	Reactive Oxygen Species	0-3	cyclin dependent kinase 1	Homo sapiens	69-73
25563361-6	2015	KUD773 induced an increase of Cdk1 phosphorylation at Thr(161) (a stimulatory phosphorylation site) and a decrease of phosphorylation at Tyr(15) (an inhibitory phosphorylation site), suggesting the activation of Cdk1.	Threonine	54-57	cyclin dependent kinase 1	Homo sapiens	30-34
26119958-0	2015	Anti-Colon Cancer Effects of 6-Shogaol Through G2/M Cell Cycle Arrest by p53/p21-cdc2/cdc25A Crosstalk.	shogaol	29-38	cyclin dependent kinase 1	Homo sapiens	81-85
26688757-3	2015	In metformin-sensitive cells, autophagy was not induced but rather it blocked proliferation by means of arresting cells in the S and G2/M phases which was associated with the downregulation of cyclin A, cyclin B1, and cdc2, but not that of cyclin E. In 10E1-CEM cells that overexpress Bcl-2 and are drug-resistant, the effect of metformin on proliferation was more pronounced, also inducing the activation of the caspases 3/7 and hence apoptosis.	Metformin	3-12	cyclin dependent kinase 1	Homo sapiens	218-222
24791855-5	2015	The specificity of Wee1 as the target of MK-1775 was validated by Wee1 knockdown, as well as partial reversal of drug combination-induced apoptosis by a cyclin-dependent kinase 1 (CDK1) inhibitor.	adavosertib	41-48	cyclin dependent kinase 1	Homo sapiens	180-184
25433945-0	2015	Knockdown of CDC2 expression inhibits proliferation, enhances apoptosis, and increases chemosensitivity to temozolomide in glioblastoma cells.	Temozolomide	107-119	cyclin dependent kinase 1	Homo sapiens	13-17
25433945-6	2015	Using RNA interference, the effects of CDC2 on chemosensitivity to temozolomide (TMZ) were investigated in U87 and U251 cell lines in vitro.	Temozolomide	67-79	cyclin dependent kinase 1	Homo sapiens	39-43
25433945-9	2015	Furthermore, expression levels of CDC2 in U87 and U251 cells were related to the IC50 of the antitumor drug TMZ.	Temozolomide	108-111	cyclin dependent kinase 1	Homo sapiens	34-38
25376608-9	2015	Loss of the cisplatin-induced checkpoint correlated with decreased Wee1 expression, increased cdc2 activation, and increased mitotic entry (p-histone H3).	Cisplatin	12-21	cyclin dependent kinase 1	Homo sapiens	94-98
25311384-5	2015	We showed that gemcitabine stabilized mutant p53 protein in the nuclei and induced chemoresistance, concurrent with the mutant p53-dependent expression of Cdk1 and CCNB1 genes, resulting in a hyperproliferation effect.	gemcitabine	15-26	cyclin dependent kinase 1	Homo sapiens	155-159
25479727-4	2015	Piperine inhibited osteosarcoma cell proliferation by causing G2/M phase cell cycle arrest associated with decreased expression of cyclin B1 and increased phosphorylation of Cyclin-dependent kinase-1(CDK1) and checkpoint kinase 2 (Chk2).	piperine	0-8	cyclin dependent kinase 1	Homo sapiens	174-199
25479727-4	2015	Piperine inhibited osteosarcoma cell proliferation by causing G2/M phase cell cycle arrest associated with decreased expression of cyclin B1 and increased phosphorylation of Cyclin-dependent kinase-1(CDK1) and checkpoint kinase 2 (Chk2).	piperine	0-8	cyclin dependent kinase 1	Homo sapiens	200-204
25465126-2	2015	Bosutinib blocked PF-00477736-induced ERK1/2 activation and sharply increased apoptosis in association with Mcl-1 inhibition, p34(cdc2) dephosphorylation, BimEL up-regulation, and DNA damage in imatinib-resistant CML or Ph(+) ALL cell lines.	bosutinib	0-9	cyclin dependent kinase 1	Homo sapiens	130-134
25545367-0	2014	Cdk1-mediated phosphorylation of human ATF7 at Thr-51 and Thr-53 promotes cell-cycle progression into M phase.	Threonine	47-50	cyclin dependent kinase 1	Homo sapiens	0-4
25588108-7	2015	Furthermore, we found that baicalein suppresses CDK4 and activates p-ERK in most leukemia cells; genistein mainly affects CDK4, p-ERK, p-CDC2, while scutellarin dysregulated the proteins, cell division control protein 42, Notch4, and XIAP.	Genistein	97-106	cyclin dependent kinase 1	Homo sapiens	137-141
25435947-7	2015	Furthermore, western blot analysis revealed that the expression levels of phospho-cdc2 (Tyr 15), cyclin A2 and cyclin B1 were increased in a time-dependent manner, following the administration of CKD-602.	Tyrosine	88-91	cyclin dependent kinase 1	Homo sapiens	82-86
25301449-6	2014	Mechanistically, SKLB316 could decrease the activities of cdc2/cyclin B1 complex, including decreasing the synthesis of cyclin B1, cdc2 and cdc25c, while accumulating the levels of phosphorylated cdc2 (Tyr15) and checkpoint kinase 2.	sklb316	17-24	cyclin dependent kinase 1	Homo sapiens	58-62
25301449-6	2014	Mechanistically, SKLB316 could decrease the activities of cdc2/cyclin B1 complex, including decreasing the synthesis of cyclin B1, cdc2 and cdc25c, while accumulating the levels of phosphorylated cdc2 (Tyr15) and checkpoint kinase 2.	sklb316	17-24	cyclin dependent kinase 1	Homo sapiens	131-135
25301449-6	2014	Mechanistically, SKLB316 could decrease the activities of cdc2/cyclin B1 complex, including decreasing the synthesis of cyclin B1, cdc2 and cdc25c, while accumulating the levels of phosphorylated cdc2 (Tyr15) and checkpoint kinase 2.	sklb316	17-24	cyclin dependent kinase 1	Homo sapiens	131-135
25545367-3	2014	Here, we show that Cdk1-cyclin B1 phosphorylates ATF2 at Thr-69/Thr-71 and ATF7 at Thr-51/Thr-53 from early prophase to anaphase in the absence of any stress stimulation.	Threonine	57-60	cyclin dependent kinase 1	Homo sapiens	19-23
25545367-0	2014	Cdk1-mediated phosphorylation of human ATF7 at Thr-51 and Thr-53 promotes cell-cycle progression into M phase.	Threonine	58-61	cyclin dependent kinase 1	Homo sapiens	0-4
25545367-3	2014	Here, we show that Cdk1-cyclin B1 phosphorylates ATF2 at Thr-69/Thr-71 and ATF7 at Thr-51/Thr-53 from early prophase to anaphase in the absence of any stress stimulation.	Threonine	64-67	cyclin dependent kinase 1	Homo sapiens	19-23
25016158-0	2014	Triple negative breast cancer therapy with CDK1 siRNA delivered by cationic lipid assisted PEG-PLA nanoparticles.	Polyethylene Glycols	91-94	cyclin dependent kinase 1	Homo sapiens	43-47
25545367-3	2014	Here, we show that Cdk1-cyclin B1 phosphorylates ATF2 at Thr-69/Thr-71 and ATF7 at Thr-51/Thr-53 from early prophase to anaphase in the absence of any stress stimulation.	Threonine	64-67	cyclin dependent kinase 1	Homo sapiens	19-23
25545367-3	2014	Here, we show that Cdk1-cyclin B1 phosphorylates ATF2 at Thr-69/Thr-71 and ATF7 at Thr-51/Thr-53 from early prophase to anaphase in the absence of any stress stimulation.	Threonine	64-67	cyclin dependent kinase 1	Homo sapiens	19-23
25060910-5	2014	Calycopterin treatment also affected HepG2 cell viability: (a) by inhibiting cell cycle progression at the G2/M transition leading to growth arrest and apoptosis; (b) by decreasing the expression of mitotic kinase cdc2, mitotic phosphatase cdc25c, mitotic cyclin B1, and apoptotic factors pro-caspases-3 and -9; and (c) increasing the levels of mitochondrial apoptotic-related proteins, intracellular levels of reactive oxygen species, and nitric oxide.	calycopterin	0-12	cyclin dependent kinase 1	Homo sapiens	214-218
25429617-5	2014	We further showed that the combination of citreoviridin and the 26S proteasome inhibitor bortezomib could improve the anticancer activity by enhancing ER stress, by ameliorating citreoviridin-caused cyclin D3 compensation, and by contributing to CDK1 deactivation and PCNA downregulation.	citreoviridin	42-55	cyclin dependent kinase 1	Homo sapiens	246-250
25429617-5	2014	We further showed that the combination of citreoviridin and the 26S proteasome inhibitor bortezomib could improve the anticancer activity by enhancing ER stress, by ameliorating citreoviridin-caused cyclin D3 compensation, and by contributing to CDK1 deactivation and PCNA downregulation.	Bortezomib	89-99	cyclin dependent kinase 1	Homo sapiens	246-250
25375373-5	2014	In addition, human pluripotent stem cells with reduced CDK1 expression accumulated a higher number of DSBs were unable to activate CHK2 expression and could not maintain G2/M arrest upon exposure to ionising radiation.	dsbs	102-106	cyclin dependent kinase 1	Homo sapiens	55-59
23554011-7	2014	Western blotting assay showed that ellagic acid promoted p21, p53 and decreased CDC2 and WEE1 for leading to G0/G1 phase arrest and promoting BAD expression, AIF and Endo G, cytochrome c, caspase-9 and -3 for leading to apoptosis in TSGH8301 cells.	Ellagic Acid	35-47	cyclin dependent kinase 1	Homo sapiens	80-84
25519703-9	2014	Of these, pathway analyses identified a panel of 7 genes (ADAM7, FAM72B, BUB1B, CCNB1, CCNB2, TTK, CDK1), including a cell cycle-related geneset, that were differentially-regulated following treatment with docetaxel and ADT.	Docetaxel	206-215	cyclin dependent kinase 1	Homo sapiens	99-103
25519703-9	2014	Of these, pathway analyses identified a panel of 7 genes (ADAM7, FAM72B, BUB1B, CCNB1, CCNB2, TTK, CDK1), including a cell cycle-related geneset, that were differentially-regulated following treatment with docetaxel and ADT.	adt	220-223	cyclin dependent kinase 1	Homo sapiens	99-103
25260383-6	2014	Our results demonstrated that deoxyelephantopin-induced G2/M phase arrest was associated with a marked increase in the levels of p53 and p21 and a decrease in phospho-signal transducer and activator of transcription 3 (pSTAT3-Tyr705), cyclin-dependent kinase 1 (cdc2), and cyclin B1.	deoxyelephantopin	30-47	cyclin dependent kinase 1	Homo sapiens	235-260
25260383-6	2014	Our results demonstrated that deoxyelephantopin-induced G2/M phase arrest was associated with a marked increase in the levels of p53 and p21 and a decrease in phospho-signal transducer and activator of transcription 3 (pSTAT3-Tyr705), cyclin-dependent kinase 1 (cdc2), and cyclin B1.	deoxyelephantopin	30-47	cyclin dependent kinase 1	Homo sapiens	262-266
25301733-6	2014	Small-molecule inhibitors of CHK1 (AZD7762) or WEE1 (MK-1775) induced mitotic catastrophe, as characterized by dephosphorylation of CDK1(Tyr15), phosphorylation of histone H39(Ser10), and apoptosis.	3-(carbamoylamino)-5-(3-fluorophenyl)-N-(3-piperidyl)thiophene-2-carboxamide	35-42	cyclin dependent kinase 1	Homo sapiens	132-136
25301733-6	2014	Small-molecule inhibitors of CHK1 (AZD7762) or WEE1 (MK-1775) induced mitotic catastrophe, as characterized by dephosphorylation of CDK1(Tyr15), phosphorylation of histone H39(Ser10), and apoptosis.	adavosertib	53-60	cyclin dependent kinase 1	Homo sapiens	132-136
25301106-8	2014	Thus, sodium arsenite may confer its cytotoxic effect partly through the aberrant activation of CDKs and the resultant perturbation of cell cycle progression.	sodium arsenite	6-21	cyclin dependent kinase 1	Homo sapiens	96-100
25217392-1	2014	PURPOSE: Dinaciclib is a novel selective inhibitor of cyclin-dependent kinase (CDK)1, CDK2, CDK5, and CDK9.	dinaciclib	9-19	cyclin dependent kinase 1	Homo sapiens	79-84
25445585-11	2014	Our findings reveal the following novel molecular mechanisms controlling mitochondrial fission during A/R injury of cardiomyocytes: (1) ROS are upstream initiators of mitochondrial fission; and (2) the increased mitochondrial fission is resulted from both increased activation and decreased inactivation of Drp1 through Cdk1, PKCdelta, and calcineurin-mediated pathways, respectively.	Reactive Oxygen Species	136-139	cyclin dependent kinase 1	Homo sapiens	320-324
25016158-0	2014	Triple negative breast cancer therapy with CDK1 siRNA delivered by cationic lipid assisted PEG-PLA nanoparticles.	pla	95-98	cyclin dependent kinase 1	Homo sapiens	43-47
24962331-5	2014	The mechanism by which MK-1775 enhanced AraC cytotoxicity was investigated in the cell lines using Western blots to probe CDK1 and H2AX phosphorylation and flow cytometry to determine apoptosis, cell cycle arrest, DNA damage, and aberrant mitotic entry.	adavosertib	23-30	cyclin dependent kinase 1	Homo sapiens	122-126
25289887-1	2014	Dinaciclib is a potent CDK1, 2, 5 and 9 inhibitor being developed for the treatment of cancer.	dinaciclib	0-10	cyclin dependent kinase 1	Homo sapiens	23-27
24962331-7	2014	MK-1775 was able to decrease inhibitory CDK1(Y15) phosphorylation at the relatively low concentration of 100 nM after only 4 hours.	adavosertib	0-7	cyclin dependent kinase 1	Homo sapiens	40-44
25202060-0	2014	Cucurbitacin-D-induced CDK1 mRNA up-regulation causes proliferation arrest of a non-small cell lung carcinoma cell line (NSCLC-N6).	cucurbitacin D	0-14	cyclin dependent kinase 1	Homo sapiens	23-27
25123426-6	2014	Escin induced G2/M-phase cell cycle arrest and thus led to a significant decrease in the expression of cyclinB1 and its activating partner cyclin-dependent kinase 1, with the concomitant induction of p21.	Escin	0-5	cyclin dependent kinase 1	Homo sapiens	139-164
25149538-6	2014	Specifically, treatment with the chemotherapeutic agent doxorubicin in certain cell lines provokes CDK1 degradation and induces apoptosis, whereas in others it inhibits destruction of the protein.	Doxorubicin	56-67	cyclin dependent kinase 1	Homo sapiens	99-103
25217394-6	2014	Western blotting detected the protein expression of p21 and p53 increased and PCNA, CDK1, cyclin B decreased in GCV+rAAV+Dox group.	Ganciclovir	112-115	cyclin dependent kinase 1	Homo sapiens	84-88
25217394-6	2014	Western blotting detected the protein expression of p21 and p53 increased and PCNA, CDK1, cyclin B decreased in GCV+rAAV+Dox group.	Doxorubicin	121-124	cyclin dependent kinase 1	Homo sapiens	84-88
25217394-6	2014	Western blotting detected the protein expression of p21 and p53 increased and PCNA, CDK1, cyclin B decreased in GCV+rAAV+Dox group.	raav	116-120	cyclin dependent kinase 1	Homo sapiens	84-88
25217394-8	2014	The therapeutic mechanism of the HSV-tk/GCV suicide gene system on human breast cancer cell line MCF-7 is probably by upregulating the expression of p21 through a p53-dependent DNA damage signalling pathway, leading the decrease of protein expression of PCNA, cyclin B, CDK1 in MCF-7 cells and promoting the cell cycle arrest at G1/S phase.	Ganciclovir	40-43	cyclin dependent kinase 1	Homo sapiens	270-274
25044115-4	2014	HKL 2H treatment down-regulated the expressions of CDK1 and cyclin B but up-regulated the level of phosphorylated CDK1.	Deuterium	4-6	cyclin dependent kinase 1	Homo sapiens	51-55
25107301-2	2014	Dinaciclib (MK-7965, formerly SCH727965) is a relatively novel CDK 1/2/5/9 inhibitor that has shown promising results in preclinical studies and an acceptable safety profile in Phase I clinical trials.	dinaciclib	0-10	cyclin dependent kinase 1	Homo sapiens	63-74
25107301-2	2014	Dinaciclib (MK-7965, formerly SCH727965) is a relatively novel CDK 1/2/5/9 inhibitor that has shown promising results in preclinical studies and an acceptable safety profile in Phase I clinical trials.	dinaciclib	12-19	cyclin dependent kinase 1	Homo sapiens	63-74
25107301-2	2014	Dinaciclib (MK-7965, formerly SCH727965) is a relatively novel CDK 1/2/5/9 inhibitor that has shown promising results in preclinical studies and an acceptable safety profile in Phase I clinical trials.	dinaciclib	30-39	cyclin dependent kinase 1	Homo sapiens	63-74
25482198-5	2014	We further identify Cdk1 as the kinase responsible for serine 48 and 333 phosphorylation, while serine 138 is phosphorylated by Plk1.	Serine	55-61	cyclin dependent kinase 1	Homo sapiens	20-24
25044115-4	2014	HKL 2H treatment down-regulated the expressions of CDK1 and cyclin B but up-regulated the level of phosphorylated CDK1.	Deuterium	4-6	cyclin dependent kinase 1	Homo sapiens	114-118
25032860-9	2014	Taken together with prior publications, these observations support a model whereby PFKFB3 and F2,6BP function not only as regulators of Pfk-1 but also of Cdk1 activity, and therefore serve to couple glucose metabolism with cell proliferation and survival in transformed cells.	Glucose	199-206	cyclin dependent kinase 1	Homo sapiens	154-158
25084614-9	2014	MK-1775 induced apoptosis in both AML cell lines and diagnostic blast samples, accompanied by decreased phosphorylation of CDK1 and CDK2 on Tyr-15 and increased DNA double-strand breaks (DSBs).	adavosertib	0-7	cyclin dependent kinase 1	Homo sapiens	123-127
25084614-9	2014	MK-1775 induced apoptosis in both AML cell lines and diagnostic blast samples, accompanied by decreased phosphorylation of CDK1 and CDK2 on Tyr-15 and increased DNA double-strand breaks (DSBs).	Tyrosine	140-143	cyclin dependent kinase 1	Homo sapiens	123-127
24792887-5	2014	Following TY04 treatment, a concomitant increase in CDK1 and cyclin B1 expression occurred.	ty04	10-14	cyclin dependent kinase 1	Homo sapiens	52-56
24858077-4	2014	Also, cucurbitacin-I induced G2/M phase cell cycle arrest in SW480 cells with a decreased expression of cell cycle proteins including cyclin B1, cyclin A, CDK1, and CDC25C.	cucurbitacin I	6-20	cyclin dependent kinase 1	Homo sapiens	155-159
23902659-5	2014	In the analyses of cytoplasmic maturation, we found that the level of p34(cdc2), a cytoplasmic maturation marker, and the monospermic fertilisation rate were higher in the 1nM rapamycin treatment group than in the other groups.	Sirolimus	176-185	cyclin dependent kinase 1	Homo sapiens	74-78
25019390-10	2014	Treatment with the PKC agonist phorbol 12-myristate 13-acetate (PMA) increased phosphorylation of PKC substrates and MAPK and increased p34cdc2 kinase activity.	Tetradecanoylphorbol Acetate	31-62	cyclin dependent kinase 1	Homo sapiens	136-143
25019390-10	2014	Treatment with the PKC agonist phorbol 12-myristate 13-acetate (PMA) increased phosphorylation of PKC substrates and MAPK and increased p34cdc2 kinase activity.	Tetradecanoylphorbol Acetate	64-67	cyclin dependent kinase 1	Homo sapiens	136-143
24677263-6	2014	CDK1-mediated Bcl-2 serine 70 phosphorylation enhances its pro-apoptotic function, whereas CDK1-mediated Bad serine 128 phosphorylation promotes apoptosis.	Serine	20-26	cyclin dependent kinase 1	Homo sapiens	0-4
24872417-5	2014	Furthermore, in contrast to Cdk1 and Cdk2, which are inhibited by phosphorylation at Tyr-15, the kinase activity of Cdk5 is reported to be stimulated when phosphorylated at Tyr-15 by Src family kinases or receptor-type tyrosine kinases.	Tyrosine	85-88	cyclin dependent kinase 1	Homo sapiens	28-32
24933638-7	2014	Furthermore, co-culture medium with low concentration of MPP+ (100 microM) arrested Jurkat cells cycle in G2/M phase through increasing cell cycle division 2 (CDC2) and CyclinB1 expression level, whereas co-culture medium with high concentration of MPP+ (500 microM) induced Jurkat cell necrosis through cellular swelling and membrane breakage.	mangion-purified polysaccharide (Candida albicans)	57-61	cyclin dependent kinase 1	Homo sapiens	159-163
24752227-7	2014	After the treatment with LL-202, the expression of cell cycle-related proteins, such as cyclin B1, cyclin A, and p-CDK1 (Thr161) were down-regulated, whereas the expression of p21(WAF1/Cip1) and p-CDK1 (Thr14/Tyr15) were up-regulated.	LL202 flavonoid	25-31	cyclin dependent kinase 1	Homo sapiens	115-119
24752227-7	2014	After the treatment with LL-202, the expression of cell cycle-related proteins, such as cyclin B1, cyclin A, and p-CDK1 (Thr161) were down-regulated, whereas the expression of p21(WAF1/Cip1) and p-CDK1 (Thr14/Tyr15) were up-regulated.	LL202 flavonoid	25-31	cyclin dependent kinase 1	Homo sapiens	197-201
24594224-10	2014	HMJ-38 stimulated the activation of CDK1 activity that modulated phosphorylation on Ser70 of Bcl-2-mediated mitotic arrest and apoptosis.	2-(3'-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone	0-6	cyclin dependent kinase 1	Homo sapiens	36-40
24978614-4	2014	We have found Kenpaullone, a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation.	kenpaullone	14-25	cyclin dependent kinase 1	Homo sapiens	36-40
24677263-6	2014	CDK1-mediated Bcl-2 serine 70 phosphorylation enhances its pro-apoptotic function, whereas CDK1-mediated Bad serine 128 phosphorylation promotes apoptosis.	Serine	109-115	cyclin dependent kinase 1	Homo sapiens	91-95
24886166-8	2014	Meanwhile, SAHA suppressed PaTu8988 cell cycle progression through inducing G2/M arrest, which was associated with cyclin-dependent kinase 1 (CDK-1)/cyclin-B1 degradation and p21/p27 upregulation.	Vorinostat	11-15	cyclin dependent kinase 1	Homo sapiens	115-140
24789439-6	2014	DHM increased the production of p53 and p21 proteins and downregulated the production of Cdc25A, Cdc2 and P-Cdc2 proteins, which induced cell cycle arrest.	dihydromyricetin	0-3	cyclin dependent kinase 1	Homo sapiens	89-93
24789439-6	2014	DHM increased the production of p53 and p21 proteins and downregulated the production of Cdc25A, Cdc2 and P-Cdc2 proteins, which induced cell cycle arrest.	dihydromyricetin	0-3	cyclin dependent kinase 1	Homo sapiens	97-101
23958962-10	2014	SNP rs2456778, which maps to CDK1 ("cyclin-dependent kinase 1"), was associated with cocaine-induced paranoia in AAs in the discovery sample only (P=4.68 x 10(-8)).	Cocaine	85-92	cyclin dependent kinase 1	Homo sapiens	29-33
23958962-10	2014	SNP rs2456778, which maps to CDK1 ("cyclin-dependent kinase 1"), was associated with cocaine-induced paranoia in AAs in the discovery sample only (P=4.68 x 10(-8)).	Cocaine	85-92	cyclin dependent kinase 1	Homo sapiens	36-62
24756776-5	2014	Forced overexpression of GRP78 protected the cisplatin-sensitive A2780 cells from cisplatin-induced senescence through P53 and CDC2.	Cisplatin	45-54	cyclin dependent kinase 1	Homo sapiens	127-131
24756776-5	2014	Forced overexpression of GRP78 protected the cisplatin-sensitive A2780 cells from cisplatin-induced senescence through P53 and CDC2.	Cisplatin	82-91	cyclin dependent kinase 1	Homo sapiens	127-131
24756776-6	2014	Knockdown of GRP78 rescued the senescence sensitivity of cisplatin-resistant C13K cells to cisplatin through P21 and CDC2.	Cisplatin	57-66	cyclin dependent kinase 1	Homo sapiens	117-121
24756776-6	2014	Knockdown of GRP78 rescued the senescence sensitivity of cisplatin-resistant C13K cells to cisplatin through P21 and CDC2.	Cisplatin	91-100	cyclin dependent kinase 1	Homo sapiens	117-121
24632590-4	2014	In this respect, rucaparib inhibits nine kinases with micromolar affinity, including PIM1, PIM2, PRKD2, DYRK1A, CDK1, CDK9, HIPK2, CK2, and ALK.	rucaparib	17-26	cyclin dependent kinase 1	Homo sapiens	112-116
24886166-8	2014	Meanwhile, SAHA suppressed PaTu8988 cell cycle progression through inducing G2/M arrest, which was associated with cyclin-dependent kinase 1 (CDK-1)/cyclin-B1 degradation and p21/p27 upregulation.	Vorinostat	11-15	cyclin dependent kinase 1	Homo sapiens	142-147
24626522-5	2014	This flavone also suppressed the expression of both cyclin B1 and its activating partners, Cdc2 and Cdc25c, whereas the expression of cell cycle inhibitors, such as p53 and p53-dependent p21(CIP1/WAF1), was increased after apigenin treatment.	flavone	5-12	cyclin dependent kinase 1	Homo sapiens	91-95
22505597-7	2014	The combined treatment of FNQ with PP2 enhanced the cell cycle arrest and apoptosis and also led to the downregulation of Bcl-XL, Mcl-1, XIAP, cyclin A, cyclin B, CDK1, and CDK2 and upregulation of p27, Bax, and Bad.	furano-1,2-naphthoquinone	26-29	cyclin dependent kinase 1	Homo sapiens	163-167
24337984-0	2014	The contribution of Cdc2 in rotenone-induced G2/M arrest and caspase-3-dependent apoptosis.	Rotenone	28-36	cyclin dependent kinase 1	Homo sapiens	20-24
24337984-7	2014	The decreased activity of Cdc2 by roscovitine or rotenone enhanced G2/M arrest.	Roscovitine	34-45	cyclin dependent kinase 1	Homo sapiens	26-30
24337984-7	2014	The decreased activity of Cdc2 by roscovitine or rotenone enhanced G2/M arrest.	Rotenone	49-57	cyclin dependent kinase 1	Homo sapiens	26-30
24337984-8	2014	The increased cells in G2/M arrest by rotenone upregulated the expression of Cdc2.	Rotenone	38-46	cyclin dependent kinase 1	Homo sapiens	77-81
24337984-10	2014	Used together, the upregulation of Cdc2 contributes to rotenone-induced caspase-3/9-dependent apoptosis, which is associated with the enhancement of G2/M arrest.	Rotenone	55-63	cyclin dependent kinase 1	Homo sapiens	35-39
24798733-3	2014	Mitotic exit in Chk2-deficient cells correlates with reduced levels of Mps1 protein and increased Cdk1-tyrosine 15 inhibitory phosphorylation.	Tyrosine	103-111	cyclin dependent kinase 1	Homo sapiens	98-102
22505597-3	2014	FNQ-induced G2/M arrest was correlated with a marked decrease in the expression levels of cyclin A and cyclin B, and their activating partner cyclin-dependent kinases (CDK) 1 and 2 with concomitant induction of p27.	furano-1,2-naphthoquinone	0-3	cyclin dependent kinase 1	Homo sapiens	142-180
24177748-8	2014	DRP1 is activated by cyclin B1-CDK1 complex by its ser616 phosphorylation in which both cyclin B1-CDK1 complex and phospho-DRP1 (ser616) were strongly reduced by NaBt treatment.	NABT	162-166	cyclin dependent kinase 1	Homo sapiens	31-35
24623419-2	2014	Phosphorylation of human SAMHD1 at threonine 592 (T592) by cyclin-dependent kinase 1 (CDK1) and cyclin A2 impairs its HIV-1 restriction activity, but not the dNTP hydrolase activity, suggesting that dNTP depletion is not the sole mechanism of SAMHD1-mediated HIV-1 restriction.	Threonine	35-44	cyclin dependent kinase 1	Homo sapiens	59-84
24623419-2	2014	Phosphorylation of human SAMHD1 at threonine 592 (T592) by cyclin-dependent kinase 1 (CDK1) and cyclin A2 impairs its HIV-1 restriction activity, but not the dNTP hydrolase activity, suggesting that dNTP depletion is not the sole mechanism of SAMHD1-mediated HIV-1 restriction.	Threonine	35-44	cyclin dependent kinase 1	Homo sapiens	86-90
24623419-2	2014	Phosphorylation of human SAMHD1 at threonine 592 (T592) by cyclin-dependent kinase 1 (CDK1) and cyclin A2 impairs its HIV-1 restriction activity, but not the dNTP hydrolase activity, suggesting that dNTP depletion is not the sole mechanism of SAMHD1-mediated HIV-1 restriction.	Allura Red AC Dye	50-54	cyclin dependent kinase 1	Homo sapiens	59-84
24623419-2	2014	Phosphorylation of human SAMHD1 at threonine 592 (T592) by cyclin-dependent kinase 1 (CDK1) and cyclin A2 impairs its HIV-1 restriction activity, but not the dNTP hydrolase activity, suggesting that dNTP depletion is not the sole mechanism of SAMHD1-mediated HIV-1 restriction.	Allura Red AC Dye	50-54	cyclin dependent kinase 1	Homo sapiens	86-90
24623419-10	2014	Previous studies suggested that phosphorylation of human SAMHD1 at threonine 592 by CDK1 and cyclin A2 negatively regulates its HIV-1 restriction activity.	Threonine	67-76	cyclin dependent kinase 1	Homo sapiens	84-88
24177748-8	2014	DRP1 is activated by cyclin B1-CDK1 complex by its ser616 phosphorylation in which both cyclin B1-CDK1 complex and phospho-DRP1 (ser616) were strongly reduced by NaBt treatment.	NABT	162-166	cyclin dependent kinase 1	Homo sapiens	98-102
24746669-5	2014	Mitochondria-targeted cyclin B1/Cdk1 increases mitochondrial respiration with enhanced oxygen consumption and ATP generation, which provides cells with efficient bioenergy for G2/M transition and shortens overall cell-cycle time.	Oxygen	87-93	cyclin dependent kinase 1	Homo sapiens	32-36
24676336-12	2014	For the TSA+DAC group, higher levels of p53, p21, cyclin B1 and Chk1 were detected, concomitant with lower levels of CDK1, when compared to the control group.	trichostatin A	8-11	cyclin dependent kinase 1	Homo sapiens	117-121
24676336-12	2014	For the TSA+DAC group, higher levels of p53, p21, cyclin B1 and Chk1 were detected, concomitant with lower levels of CDK1, when compared to the control group.	Decitabine	12-15	cyclin dependent kinase 1	Homo sapiens	117-121
24746669-5	2014	Mitochondria-targeted cyclin B1/Cdk1 increases mitochondrial respiration with enhanced oxygen consumption and ATP generation, which provides cells with efficient bioenergy for G2/M transition and shortens overall cell-cycle time.	Adenosine Triphosphate	110-113	cyclin dependent kinase 1	Homo sapiens	32-36
24722413-3	2014	Subsequent studies reveal that PBD binds to a phosphorylated motif generated by one of the two mechanisms-self-priming by Plk1 itself or non-selfpriming by a Pro-directed kinase, such as Cdc2.	pbd	31-34	cyclin dependent kinase 1	Homo sapiens	187-191
24365782-6	2014	As expected, the enhancement in cisplatin toxicity was accompanied by a decrease in the inactive phosphorylated form of cyclin-dependent kinase 1 (CDK1), a key substrate of WEE1, which is indicative of G 2/M checkpoint inactivation.	Cisplatin	32-41	cyclin dependent kinase 1	Homo sapiens	120-145
24365782-6	2014	As expected, the enhancement in cisplatin toxicity was accompanied by a decrease in the inactive phosphorylated form of cyclin-dependent kinase 1 (CDK1), a key substrate of WEE1, which is indicative of G 2/M checkpoint inactivation.	Cisplatin	32-41	cyclin dependent kinase 1	Homo sapiens	147-151
24325868-7	2014	This increase in Cyclin B1 and CDC25C both together facilitated activation of cyclin B complex via dephosphorylating CDK1((T14Y15)), and resumed the G2/M transition after nocodazole synchronization.	Nocodazole	171-181	cyclin dependent kinase 1	Homo sapiens	117-121
24632106-4	2014	The results showed that TBT caused a G2/M cell cycle arrest that was accompanied by a decrease in the total cdc25C protein level and an increase in the p-cdc2 level in the nucleus.	tributyltin	24-27	cyclin dependent kinase 1	Homo sapiens	108-112
24632106-6	2014	Taken together, TBT leads to a G2/M cell cycle arrest in FL cells, an increase in p-cdc2 and a decrease in the levels of total cdc25C protein, which may be caused by the PP2A inhibition-mediated inactivation of the ERK1/2 cascades.	tributyltin	16-19	cyclin dependent kinase 1	Homo sapiens	84-88
24218335-12	2014	The influence on the level of cylinB1, CDK1, and p21 was also observed after bufalin treatment, and the relationship between Hsp27 and the cell cycle-related proteins mentioned above deserves much more research.	bufalin	77-84	cyclin dependent kinase 1	Homo sapiens	39-43
24378347-0	2014	The CDK1 inhibitor RO3306 improves the response of BRCA-proficient breast cancer cells to PARP inhibition.	RO 3306	19-25	cyclin dependent kinase 1	Homo sapiens	4-8
24362465-3	2014	Exposure of cells to extremely low (e.g., nmol/L) concentrations of SCH727965, a potent inhibitor of CDKs 1/2/5/9, diminished XBP-1s and Grp78 induction by the endoplasmic reticulum (ER) stress-inducers thapsigargin and tunicamycin, while sharply inducing cell death.	dinaciclib	68-77	cyclin dependent kinase 1	Homo sapiens	101-113
24362465-5	2014	Notably, in human leukemia cells, CDK1 and 5 short hairpin RNA (shRNA) knockdown diminished Grp78 and XBP-1s upregulation while increasing thapsigargin lethality, arguing for a functional role for CDK1/5 in activation of the cytoprotective IRE1/XBP-1s arm of the UPR.	Thapsigargin	139-151	cyclin dependent kinase 1	Homo sapiens	34-44
24527087-6	2014	Imatinib significantly induced G1 arrest, reduced the phosphorylation of cyclin-dependent kinase 1 and retinoblastoma proteins and inhibited the proliferation of CD34+ cells from patients with CML in the megakaryocytic crisis phase.	Imatinib Mesylate	0-8	cyclin dependent kinase 1	Homo sapiens	73-98
24505404-9	2014	Taken together, these results suggested that Cuc B induces DNA damage in A549 cells mediated by increasing intracellular ROS formation, which lead to G2/M cell phase arrest through ATM-activated Chk1-Cdc25C-Cdk1 and p53-14-3-3-sigma parallel branches.	cucurbitacin B	45-50	cyclin dependent kinase 1	Homo sapiens	207-211
24495785-5	2014	The combination of PEITC and taxol also reduced expressions of cell cycle regulator Cdk1, and anti-apoptotic protein bcl-2, enhanced expression of Bax and cleavage of PARP proteins.	phenethyl isothiocyanate	19-24	cyclin dependent kinase 1	Homo sapiens	84-88
24495785-5	2014	The combination of PEITC and taxol also reduced expressions of cell cycle regulator Cdk1, and anti-apoptotic protein bcl-2, enhanced expression of Bax and cleavage of PARP proteins.	Paclitaxel	29-34	cyclin dependent kinase 1	Homo sapiens	84-88
24505404-9	2014	Taken together, these results suggested that Cuc B induces DNA damage in A549 cells mediated by increasing intracellular ROS formation, which lead to G2/M cell phase arrest through ATM-activated Chk1-Cdc25C-Cdk1 and p53-14-3-3-sigma parallel branches.	Reactive Oxygen Species	121-124	cyclin dependent kinase 1	Homo sapiens	207-211
24296129-3	2014	The sulforaphane-induced mitotic arrest correlated with an induction of cyclin B1 and phosphorylation of Cdk1, as well as a concomitant increased complex between cyclin B1 and Cdk1.	sulforaphane	4-16	cyclin dependent kinase 1	Homo sapiens	105-109
23924154-8	2014	SAMHD1 amino acid residue T592, a target of CDK1 phosphorylation, was unphosphorylated, corresponding to the antiviral form of the enzyme.	Allura Red AC Dye	26-30	cyclin dependent kinase 1	Homo sapiens	44-48
24321771-8	2014	RO-3306, a cdk-1 inhibitor, induced a 90% arrest in G2/M reversible in less than 15min.	RO 3306	0-7	cyclin dependent kinase 1	Homo sapiens	11-16
24296129-3	2014	The sulforaphane-induced mitotic arrest correlated with an induction of cyclin B1 and phosphorylation of Cdk1, as well as a concomitant increased complex between cyclin B1 and Cdk1.	sulforaphane	4-16	cyclin dependent kinase 1	Homo sapiens	176-180
24327015-7	2014	Using small-molecule inhibitors specific for these three proteins also led to growth inhibition of MPM cell lines, and Roscovitine (inhibitor of CDK1) sensitised cells to cisplatin.	Roscovitine	119-130	cyclin dependent kinase 1	Homo sapiens	145-149
22949227-0	2014	Role of cyclin B1/Cdc2 in mediating Bcl-XL phosphorylation and apoptotic cell death following nocodazole-induced mitotic arrest.	Nocodazole	94-104	cyclin dependent kinase 1	Homo sapiens	18-22
22949227-3	2014	We recently showed that cyclin B1 and cell division cycle 2 (Cdc2) proteins are strongly up-regulated in human breast cancer cells following treatment with nocodazole (a prototypical microtubule inhibitor), and their up-regulation plays a critical role in the development of mitotic prometaphase arrest.	Nocodazole	156-166	cyclin dependent kinase 1	Homo sapiens	38-59
22949227-3	2014	We recently showed that cyclin B1 and cell division cycle 2 (Cdc2) proteins are strongly up-regulated in human breast cancer cells following treatment with nocodazole (a prototypical microtubule inhibitor), and their up-regulation plays a critical role in the development of mitotic prometaphase arrest.	Nocodazole	156-166	cyclin dependent kinase 1	Homo sapiens	61-65
22949227-4	2014	In this study, we present evidence showing that the up-regulated cyclin B1/Cdc2 complex in nocodazole-treated human breast cancer cells is also responsible for the increased phosphorylation of Bcl-2 and Bcl-XL .	Nocodazole	91-101	cyclin dependent kinase 1	Homo sapiens	75-79
22949227-6	2014	In addition, evidence is presented to show that mitotic arrest deficient 2 (MAD2) is a key upstream mediator of the up-regulation of cyclin B1/Cdc2 as well as the subsequent increase in phosphorylationof Bcl-2 and Bcl-XL in nocodazole-treated cancer cells.	Nocodazole	224-234	cyclin dependent kinase 1	Homo sapiens	143-147
22949227-7	2014	Together, these results reveal that the up-regulated cyclin B1/Cdc2 complex not only mediates prometaphase arrest in nocodazole-treated cells, but also activates the subsequent intrinsic cell death pathway in these cells via increased phosphorylation of Bcl-XL .	Nocodazole	117-127	cyclin dependent kinase 1	Homo sapiens	63-67
24374180-0	2014	A specific inhibitor of CDK1, RO-3306, reversibly arrests meiosis during in vitro maturation of porcine oocytes.	RO 3306	30-37	cyclin dependent kinase 1	Homo sapiens	24-28
24374180-2	2014	In this study, we investigated the possibility of utilizing a selective inhibitor of CDK1, RO-3306, as a novel agent for the synchronization of oocyte maturation.	RO 3306	91-98	cyclin dependent kinase 1	Homo sapiens	85-89
24374180-10	2014	RO-3306 treatment increased expression of CDK1 but had no effect on the expression of the other genes.	RO 3306	0-7	cyclin dependent kinase 1	Homo sapiens	42-46
24258347-8	2014	The decline in AR phosphorylation at Ser-81 by mahanine occurs via the inactivation of mitotic kinase CDK1.	Serine	37-40	cyclin dependent kinase 1	Homo sapiens	102-106
24258347-8	2014	The decline in AR phosphorylation at Ser-81 by mahanine occurs via the inactivation of mitotic kinase CDK1.	mahanine	47-55	cyclin dependent kinase 1	Homo sapiens	102-106
24327015-7	2014	Using small-molecule inhibitors specific for these three proteins also led to growth inhibition of MPM cell lines, and Roscovitine (inhibitor of CDK1) sensitised cells to cisplatin.	Cisplatin	171-180	cyclin dependent kinase 1	Homo sapiens	145-149
24304238-1	2014	Evaluation of the effects of purine C-8 substitution within a series of CDK1/2-selective O(6)-cyclohexylmethylguanine derivatives revealed that potency decreases initially with increasing size of the alkyl substituent.	purine	29-35	cyclin dependent kinase 1	Homo sapiens	72-76
24304238-1	2014	Evaluation of the effects of purine C-8 substitution within a series of CDK1/2-selective O(6)-cyclohexylmethylguanine derivatives revealed that potency decreases initially with increasing size of the alkyl substituent.	NU2058	89-117	cyclin dependent kinase 1	Homo sapiens	72-76
24166139-8	2014	NOC-induced phosphorylation of Bcl-2 and Bim, Deltapsim loss, and mitochondria-dependent apoptotic events were significantly suppressed by a Cdk1 inhibitor roscovitine, but not by the JNK inhibitor SP600125 or the p38 MAPK inhibitor SB203580.	Roscovitine	156-167	cyclin dependent kinase 1	Homo sapiens	141-145
25124639-0	2014	Downregulation of Cdk1 and cyclinB1 expression contributes to oridonin-induced cell cycle arrest at G2/M phase and growth inhibition in SGC-7901 gastric cancer cells.	oridonin	62-70	cyclin dependent kinase 1	Homo sapiens	18-22
25124639-6	2014	CONCLUSIONS: Oridonin may inhibit SGC-7901 growth and block the cells in the G2/M phase by decreasing Cdk1 and cyclinB1 proteins.	oridonin	13-21	cyclin dependent kinase 1	Homo sapiens	102-106
25483135-7	2014	These unexpected complexities in Cdk1 inhibitory phosphorylation demonstrate that the checkpoint mechanism is not a simple binary "off/on" switch, but has at least three distinct states: "Ready", to prevent chromosome damage and apoptosis, "Set", for developmentally regulated G2 phase arrest, and "Go", when Cdc25 phosphatases remove inhibitory phosphates to trigger Cdk1 activation at the G2/M transition.	Phosphates	346-356	cyclin dependent kinase 1	Homo sapiens	33-37
24815485-4	2014	RESULTS: Further experiments showed that alpha-pinene inhibited BEL-7402 cells by arresting cell growth in the G2/M phase of the cell cycle, downregulating Cdc25C mRNA and protein expression, and reducing cycle dependence on kinase 1(CDK1) activity.	alpha-pinene	41-53	cyclin dependent kinase 1	Homo sapiens	234-238
24626186-2	2014	In this study we utilized low doses of the Cdk1-specific inhibitor, RO3306 from early G 2 phase onwards.	RO 3306	68-74	cyclin dependent kinase 1	Homo sapiens	43-47
24626186-7	2014	Furthermore, cells treated with medium doses of RO3306 were only able to reach the threshold of Cdk1 substrate phosphorylation required to initiate nuclear envelope breakdown, but failed to reach the levels of phosphorylation required to correctly complete pro-metaphase.	RO 3306	48-54	cyclin dependent kinase 1	Homo sapiens	96-100
25169527-8	2014	Silibinin caused G2/M phage arrest accompanied by a decrease in CDK1 and Cyclin B1 at protein and mRNA levels..	Silybin	0-9	cyclin dependent kinase 1	Homo sapiens	64-68
25169527-9	2014	CONCLUSIONS: These results suggest that silibinin inhibits the proliferation of MGC803 cells, and it induces apoptosis and causes cell cycle arrest by down-regulating CDK1, cyclinB1, survivin, Bcl-xl, Mcl-1 and activating caspase 3 and caspase 9, potentially via the STAT3 pathway.	Silybin	40-49	cyclin dependent kinase 1	Homo sapiens	167-171
24180279-4	2014	The most active compound of this series acts as a CDK1 inhibitor, and was found to cause cell cycle arrest at G2/M phase, to induce apoptosis by preventing the phosphorylation of survivin in Thr(34) and to increase the cytotoxic activity of paclitaxel in STO cells.	Paclitaxel	241-251	cyclin dependent kinase 1	Homo sapiens	50-54
24190633-6	2014	MHY218 induced G2/M phase arrest in the cell cycle progression which was observed by flow cytometry analysis, and a decrease in the protein expression of cyclin B1 and its activating partners Cdc25C and Cdc2.	N1-hydroxy-N8-(4-phenoxyphenyl)octanediamide	0-6	cyclin dependent kinase 1	Homo sapiens	192-196
24091728-4	2013	Using synchronized HeLa cells released from a double thymidine block (G 1/S boundary) or the Cdk1 inhibitor, RO3306 (G 2/M boundary), we have systematically re-addressed this dogma.	RO 3306	109-115	cyclin dependent kinase 1	Homo sapiens	93-97
23604974-7	2014	The inhibition of LoVo cell growth by berberine was associated with the suppression of cyclin B1, cdc2, and cdc25c proteins.	Berberine	38-47	cyclin dependent kinase 1	Homo sapiens	98-102
24195507-0	2014	Cyclin-dependent kinase 1 inhibitor RO3306 promotes mitotic slippage in paclitaxel-treated HepG2 cells.	RO 3306	36-42	cyclin dependent kinase 1	Homo sapiens	0-25
24195507-0	2014	Cyclin-dependent kinase 1 inhibitor RO3306 promotes mitotic slippage in paclitaxel-treated HepG2 cells.	Paclitaxel	72-82	cyclin dependent kinase 1	Homo sapiens	0-25
24195507-4	2014	We investigated the effect of a sequential combination of PTX and RO3306, a cyclin-dependent kinase 1 inhibitor, on the hepatocellular carcinoma HepG2 cell line.	RO 3306	66-72	cyclin dependent kinase 1	Homo sapiens	76-101
26168133-7	2014	Berberine induced cell cycle arrest at the G2/M phase by upregulation of p53 and p21 expression and suppressed cyclin B1, cyclin-dependent kinase 1 (cdc2), cdc25c, and phosphorylated retinoblastoma tumor-suppressor protein (pRb) expression.	Berberine	0-9	cyclin dependent kinase 1	Homo sapiens	122-147
26168133-7	2014	Berberine induced cell cycle arrest at the G2/M phase by upregulation of p53 and p21 expression and suppressed cyclin B1, cyclin-dependent kinase 1 (cdc2), cdc25c, and phosphorylated retinoblastoma tumor-suppressor protein (pRb) expression.	Berberine	0-9	cyclin dependent kinase 1	Homo sapiens	149-153
26168133-9	2014	Inhibition of phosphatidylinositol 3-kinase (PI3K)/Akt with LY294002 (LY) and p38 kinase with SB203580 (SB), respectively, decreased berberine-induced p53 and p21 expression and restored cell proliferation and expression of cyclin B1, cdc2, cdc25c, and pRb cell cycle progression proteins.	Berberine	133-142	cyclin dependent kinase 1	Homo sapiens	235-239
24231363-5	2013	DPMA also affected cyclinB1, cdc2 and p-cdc2 expression, inducing cell cycle arrest.	CGS 24012	0-4	cyclin dependent kinase 1	Homo sapiens	29-33
24231363-5	2013	DPMA also affected cyclinB1, cdc2 and p-cdc2 expression, inducing cell cycle arrest.	CGS 24012	0-4	cyclin dependent kinase 1	Homo sapiens	40-44
23848205-9	2013	Since curcumin is known to inhibit the cyclin D1-dependent G1/S-phase kinase CDK4 and the cyclin B-dependent G2/M-phase kinase CDK1 that catalyze phosphorylation-mediated inactivation of Rb, our results indicate that SunC containing a lower dose of sunitinib would be effective in restoring the tumor suppressor activity of Rb, thereby truncating cell cycle and triggering cell death.	Curcumin	6-14	cyclin dependent kinase 1	Homo sapiens	127-131
23848205-9	2013	Since curcumin is known to inhibit the cyclin D1-dependent G1/S-phase kinase CDK4 and the cyclin B-dependent G2/M-phase kinase CDK1 that catalyze phosphorylation-mediated inactivation of Rb, our results indicate that SunC containing a lower dose of sunitinib would be effective in restoring the tumor suppressor activity of Rb, thereby truncating cell cycle and triggering cell death.	Sunitinib	249-258	cyclin dependent kinase 1	Homo sapiens	127-131
23477782-0	2014	Approaches to a multitargeting drug development: first profiled 3- ethoxycarbonyl-1-aza-9-oxafluorenes representing a perspective compound class targeting Alzheimer disease relevant kinases CDK1, CDK5 and GSK-3beta.	3- ethoxycarbonyl-1-aza-9-oxafluorenes	64-102	cyclin dependent kinase 1	Homo sapiens	190-194
24091728-7	2013	Furthermore, we show that inhibition of translation in response to extended times of exposure to nocodazole reflects increased eIF2alpha phosphorylation, disaggregation of polysomes, and hyperphosphorylation of selected initiation factors, including novel Cdk1-dependent N-terminal phosphorylation of eIF4GII.	Nocodazole	97-107	cyclin dependent kinase 1	Homo sapiens	256-260
24064966-7	2013	LDH inhibition by oxamate induced G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promoted apoptosis through enhancement of mitochondrial ROS generation.	Oxamic Acid	18-25	cyclin dependent kinase 1	Homo sapiens	83-87
24118195-8	2013	While oxaliplatin induced p53- and p21-dependent G2 -phase arrest associated with downregulation of cyclin B1 and Cdk1, LA-12 allowed cells to enter M-phase of the cell cycle regardless of p53/p21 status.	Oxaliplatin	6-17	cyclin dependent kinase 1	Homo sapiens	114-118
23926120-6	2013	Moreover, 5DT dose-dependently upregulated p53 and p21(Cip1/Waf1), and downregulated Cdc-2 (Cdk-1) and cyclin B1.	gardenin B	10-13	cyclin dependent kinase 1	Homo sapiens	85-90
23926120-6	2013	Moreover, 5DT dose-dependently upregulated p53 and p21(Cip1/Waf1), and downregulated Cdc-2 (Cdk-1) and cyclin B1.	gardenin B	10-13	cyclin dependent kinase 1	Homo sapiens	92-97
24044460-2	2013	In contrast, Ara-C significantly upregulated Atg5 and Beclin-1 expression, the ratio of LC3-II/LC3-I, and CDK1 and cyclin B1 expression in leukemia cells expressing BMP4.	Cytarabine	13-18	cyclin dependent kinase 1	Homo sapiens	106-110
24134853-6	2013	Chalcone A also increased CDK1/cyclin B ratios and decreased the mitochondrial transmembrane potential (DeltaPsim).	chalcone a	0-10	cyclin dependent kinase 1	Homo sapiens	26-30
24021754-6	2013	Kobophenol A stimulation induced the expression of the cyclin B1 and cyclin-dependent kinase 1 (CDK1).	kobophenol A	0-12	cyclin dependent kinase 1	Homo sapiens	69-94
24021754-6	2013	Kobophenol A stimulation induced the expression of the cyclin B1 and cyclin-dependent kinase 1 (CDK1).	kobophenol A	0-12	cyclin dependent kinase 1	Homo sapiens	96-100
24284485-8	2013	These results suggest that genistein induces G2/M arrest by the activation of the ATM/Chk2/Cdc25C/Cdc2 checkpoint pathway and ultimately enhances the radiosensitivity of both ER+ and ER- breast cancer cells through a mitochondria-mediated apoptosis pathway.	Genistein	27-36	cyclin dependent kinase 1	Homo sapiens	91-95
24260076-5	2013	In conclusion, these results indicate for the first time that the regulation of the CDK4/6-cyclin D and CDK1-cyclin B complexes may participate in the anticancer activity pathway of O-DMA in MCF-7 cells.	O-desmethylangolensin	182-187	cyclin dependent kinase 1	Homo sapiens	104-108
24312139-3	2013	The spindle-assembly checkpoint (SAC) is known to be activated during mitosis, along with cyclin-dependent kinase-1 (CDK1), and is required for taxane-induced cell death.	taxane	144-150	cyclin dependent kinase 1	Homo sapiens	90-115
24312139-3	2013	The spindle-assembly checkpoint (SAC) is known to be activated during mitosis, along with cyclin-dependent kinase-1 (CDK1), and is required for taxane-induced cell death.	taxane	144-150	cyclin dependent kinase 1	Homo sapiens	117-121
24312139-4	2013	We hypothesized that CDK1 activity predicts response to taxane-containing chemotherapy.	taxane	56-62	cyclin dependent kinase 1	Homo sapiens	21-25
24047698-4	2013	The genomic spaces related to erlotinib resistance included a preponderance of cell cycle genes (E2F1, - 2, CDC2, -6) and DNA replication-related genes (MCM4, - 5, - 6, - 7), most of which are associated with early lung development and poor prognosis.	Erlotinib Hydrochloride	30-39	cyclin dependent kinase 1	Homo sapiens	108-112
23943501-4	2013	We investigated the effect of a cyclin-dependent kinase (Cdk) inhibitor flavopiridol (FP) that inhibits the action of Cdc2, a key protein in the G2 checkpoint pathway, on TMZ-treated glioma cells.	alvocidib	72-84	cyclin dependent kinase 1	Homo sapiens	118-122
23943501-4	2013	We investigated the effect of a cyclin-dependent kinase (Cdk) inhibitor flavopiridol (FP) that inhibits the action of Cdc2, a key protein in the G2 checkpoint pathway, on TMZ-treated glioma cells.	alvocidib	86-88	cyclin dependent kinase 1	Homo sapiens	118-122
23943501-4	2013	We investigated the effect of a cyclin-dependent kinase (Cdk) inhibitor flavopiridol (FP) that inhibits the action of Cdc2, a key protein in the G2 checkpoint pathway, on TMZ-treated glioma cells.	Temozolomide	171-174	cyclin dependent kinase 1	Homo sapiens	118-122
24002546-3	2013	DHM induced G2/M cell-cycle arrest in HepG2 and Hep3B cells by altering the expression of cell cycle proteins such as cyclin A, cyclin B1, Cdk1, p53, Cdc25c, p-Cdc25c Chk1 and Chk, which are critical for G2/M transition.	dihydromyricetin	0-3	cyclin dependent kinase 1	Homo sapiens	139-143
23707954-2	2013	Under these conditions, phosphorylation at Thr161 and dephosphorylation at Tyr15 of Cdk1, upregulation of cyclin B1 level, histone H1 phosphorylation, Cdc25C phosphorylation at Thr-48, Bcl-2 phosphorylation at Thr-56 and Ser-70, Mcl-1 phosphorylation, and Bim phosphorylation were detected in the presence of Bcl-2 overexpression.	Threonine	177-180	cyclin dependent kinase 1	Homo sapiens	84-88
23707954-2	2013	Under these conditions, phosphorylation at Thr161 and dephosphorylation at Tyr15 of Cdk1, upregulation of cyclin B1 level, histone H1 phosphorylation, Cdc25C phosphorylation at Thr-48, Bcl-2 phosphorylation at Thr-56 and Ser-70, Mcl-1 phosphorylation, and Bim phosphorylation were detected in the presence of Bcl-2 overexpression.	Serine	221-224	cyclin dependent kinase 1	Homo sapiens	84-88
23707954-5	2013	The 17alpha-E2-induced phosphorylation of Bcl-2 family proteins and mitochondrial apoptotic events were suppressed by a Cdk1 inhibitor but not by aurora A and aurora B kinase inhibitors.	17alpha-e2	4-14	cyclin dependent kinase 1	Homo sapiens	120-124
23686743-7	2013	In conclusion, corilagin is a potential antitumour drug that is effective in retarding the growth of HCC, which is correlated with the activation of p-p53-p21(Cip1) -cdc2/cyclin B1.	corilagin	15-24	cyclin dependent kinase 1	Homo sapiens	166-170
23939380-3	2013	Given the fact that the aberrant activation of cyclin-dependent kinases (CDK) is frequently observed in hepatocellular carcinomas, we focused on the efficacy of the novel compounds BA-12 and BP-14 that antagonize CDK1/2/5/7 and CDK9.	ba-12	181-186	cyclin dependent kinase 1	Homo sapiens	213-223
24013421-0	2013	Ubp-M serine 552 phosphorylation by cyclin-dependent kinase 1 regulates cell cycle progression.	Serine	6-12	cyclin dependent kinase 1	Homo sapiens	36-61
24013421-3	2013	Here, we report that cyclin-dependent kinase 1 (CDK1) phosphorylates the histone H2A deubiquitinase Ubp-M at serine 552 (S552P), and, importantly, this phosphorylation is required for cell cycle progression.	Serine	109-115	cyclin dependent kinase 1	Homo sapiens	21-46
24013421-3	2013	Here, we report that cyclin-dependent kinase 1 (CDK1) phosphorylates the histone H2A deubiquitinase Ubp-M at serine 552 (S552P), and, importantly, this phosphorylation is required for cell cycle progression.	Serine	109-115	cyclin dependent kinase 1	Homo sapiens	48-52
24098799-12	2013	Surprisingly, LY2603618 treatments caused substantial down-regulation of total CDK1.	LY2603618	14-23	cyclin dependent kinase 1	Homo sapiens	79-83
24058878-8	2013	Furthermore, we find that the ability of docetaxel to increase cyclin B1/Cdk1-mediated phosphorylation of Bcl-2/Bcl-xL and decrease Mcl-1 is required for ABT-737 to enhance apoptosis in PC3 cells, as determined by addition of Cdk1 inhibitor purvalanol A and expression of shRNA specific for cyclin B1.	Docetaxel	41-50	cyclin dependent kinase 1	Homo sapiens	73-77
23954627-3	2013	By combining this substrate in a western blot method using fluorochrome based antibodies and phospho-imager analysis, we measured the Km of ATP binding to Cdk1 to be 3.5 muM.	Adenosine Triphosphate	140-143	cyclin dependent kinase 1	Homo sapiens	155-159
24058878-8	2013	Furthermore, we find that the ability of docetaxel to increase cyclin B1/Cdk1-mediated phosphorylation of Bcl-2/Bcl-xL and decrease Mcl-1 is required for ABT-737 to enhance apoptosis in PC3 cells, as determined by addition of Cdk1 inhibitor purvalanol A and expression of shRNA specific for cyclin B1.	Docetaxel	41-50	cyclin dependent kinase 1	Homo sapiens	226-230
24058878-8	2013	Furthermore, we find that the ability of docetaxel to increase cyclin B1/Cdk1-mediated phosphorylation of Bcl-2/Bcl-xL and decrease Mcl-1 is required for ABT-737 to enhance apoptosis in PC3 cells, as determined by addition of Cdk1 inhibitor purvalanol A and expression of shRNA specific for cyclin B1.	ABT-737	154-161	cyclin dependent kinase 1	Homo sapiens	73-77
24058878-8	2013	Furthermore, we find that the ability of docetaxel to increase cyclin B1/Cdk1-mediated phosphorylation of Bcl-2/Bcl-xL and decrease Mcl-1 is required for ABT-737 to enhance apoptosis in PC3 cells, as determined by addition of Cdk1 inhibitor purvalanol A and expression of shRNA specific for cyclin B1.	ABT-737	154-161	cyclin dependent kinase 1	Homo sapiens	226-230
24058878-8	2013	Furthermore, we find that the ability of docetaxel to increase cyclin B1/Cdk1-mediated phosphorylation of Bcl-2/Bcl-xL and decrease Mcl-1 is required for ABT-737 to enhance apoptosis in PC3 cells, as determined by addition of Cdk1 inhibitor purvalanol A and expression of shRNA specific for cyclin B1.	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	241-253	cyclin dependent kinase 1	Homo sapiens	73-77
25337553-10	2013	Additionally, kaempferol decreased the levels of Cdc25C, Cdc2, and cyclin B1 proteins, as well as the activity of Cdc2.	kaempferol	14-24	cyclin dependent kinase 1	Homo sapiens	49-53
25337553-10	2013	Additionally, kaempferol decreased the levels of Cdc25C, Cdc2, and cyclin B1 proteins, as well as the activity of Cdc2.	kaempferol	14-24	cyclin dependent kinase 1	Homo sapiens	57-61
25337553-11	2013	CONCLUSIONS: The present results indicate that kaempferol induces G1 and G2/M cell cycle arrest by inhibiting the activity of CDK2, CDK4, and Cdc2.	kaempferol	47-57	cyclin dependent kinase 1	Homo sapiens	142-146
23802687-5	2013	UVA plus 1, 3 and 6 increased Chk1 phosphorylation and reduced cdc2 (Thr 161) phosphorylation in melanoma cells.	Threonine	69-72	cyclin dependent kinase 1	Homo sapiens	63-67
23615402-3	2013	The mitotic arrest caused by CWJ-082 found to be due to increases in the activation of cyclin-dependent kinase 1/cyclin B1 complex and the phosphorylation of histone H3.	cwj-082	29-36	cyclin dependent kinase 1	Homo sapiens	87-112
24009741-0	2013	The flavonoid apigenin downregulates CDK1 by directly targeting ribosomal protein S9.	Flavonoids	4-13	cyclin dependent kinase 1	Homo sapiens	37-41
23814058-0	2013	Cyclin-dependent kinase 1-dependent phosphorylation of cAMP response element-binding protein decreases chromatin occupancy.	Cyclic AMP	55-59	cyclin dependent kinase 1	Homo sapiens	0-25
23814058-7	2013	We show that, rather than being induced by DNA damage, Ser-270 and Ser-271 of CREB cophosphorylated in a CDK1-dependent manner during G2/M phase.	Serine	55-58	cyclin dependent kinase 1	Homo sapiens	105-109
23814058-7	2013	We show that, rather than being induced by DNA damage, Ser-270 and Ser-271 of CREB cophosphorylated in a CDK1-dependent manner during G2/M phase.	Serine	67-70	cyclin dependent kinase 1	Homo sapiens	105-109
23769740-4	2013	Broussoflavonol B induced cell cycle arrest at both the G0/G1 and G2/M phases accompanied by a downregulation of c-Myc protein, a upregulation of the cell cycle inhibitory proteins p16(INK4a), p19(INK4D) and p21(WAF1/CIP1) and a down-regulation of the expression levels of the G2/M regulatory proteins such as cyclin B1, cdc2 and cdc25C.	broussoflavonol B	0-17	cyclin dependent kinase 1	Homo sapiens	321-325
23470834-6	2013	Western blot and real-time PCR analyses further confirmed that melatonin"s inhibitory effect was possibly because of downregulation of cyclin D1 and CDK4, related to the G(1) phase, and of cyclin B1 and CDK1, related to the G(2)/M phase.	Melatonin	63-72	cyclin dependent kinase 1	Homo sapiens	203-207
23470834-8	2013	These findings provide evidence that melatonin may significantly inhibit human osteosarcoma cell proliferation in a dose-dependent and time-dependent manner and this inhibition involves the downregulation of cyclin D1, CDK4, cyclin B1 and CDK1.	Melatonin	37-46	cyclin dependent kinase 1	Homo sapiens	239-243
23816136-0	2013	miR-381, a novel intrinsic WEE1 inhibitor, sensitizes renal cancer cells to 5-FU by up-regulation of Cdc2 activities in 786-O.	Fluorouracil	76-80	cyclin dependent kinase 1	Homo sapiens	101-105
23688861-5	2013	Brucine-mediated cell cycle arrest in G1 phase was associated with a marked increase of protein levels of CCND1 and decrease in CCNB1, cyclin E and CDC2.	brucine	0-7	cyclin dependent kinase 1	Homo sapiens	148-152
23729730-5	2013	Here, we report that human Crm1 is phosphorylated at serine 391 in mitosis by CDK1-cyclin-B (i.e. the CDK1 and cyclin B complex).	Serine	53-59	cyclin dependent kinase 1	Homo sapiens	78-82
23729730-5	2013	Here, we report that human Crm1 is phosphorylated at serine 391 in mitosis by CDK1-cyclin-B (i.e. the CDK1 and cyclin B complex).	Serine	53-59	cyclin dependent kinase 1	Homo sapiens	102-106
23816136-7	2013	miR-381 combined with 5-FU led to Cdc2 activation, mitotic catastrophe, and cell apoptosis through inhibitory WEE1.	Fluorouracil	22-26	cyclin dependent kinase 1	Homo sapiens	34-38
23720738-9	2013	In addition, we found that MCM7 could also be phosphorylated by cyclin B/Cdk1 on Ser-121 both in vitro and in vivo.	Serine	81-84	cyclin dependent kinase 1	Homo sapiens	73-77
22407812-7	2013	BA induced cell cycle arrest in the G2/M phase and increased Myt-1 mRNA (a microRNA-27a target gene), which causes inhibition in G2/M by phosphorylation of cdc2.	betulinic acid	0-2	cyclin dependent kinase 1	Homo sapiens	156-160
23870088-5	2013	We found that phosphorylation of Thr-19 is required for generating the P-STM phosphoepitope in lamin A/C and showed that it could be created in vitro by p34cdc2/cyclin B kinase (CDK1)-catalyzed phosphorylation of lamin A/C immunoprecipitated from unsynchronized HeLa S3 cells.	Threonine	33-36	cyclin dependent kinase 1	Homo sapiens	153-160
23870088-5	2013	We found that phosphorylation of Thr-19 is required for generating the P-STM phosphoepitope in lamin A/C and showed that it could be created in vitro by p34cdc2/cyclin B kinase (CDK1)-catalyzed phosphorylation of lamin A/C immunoprecipitated from unsynchronized HeLa S3 cells.	Threonine	33-36	cyclin dependent kinase 1	Homo sapiens	178-182
23525902-3	2013	The complexity of Cdk1 regulation has made it difficult to determine whether these different roles require different thresholds of kinase activity and whether the surge of activity as inhibitory phosphates are removed at mitotic onset is essential for cell proliferation.	Phosphates	195-205	cyclin dependent kinase 1	Homo sapiens	18-22
23525902-5	2013	We rescued cells lethally depleted of endogenous Cdk1 with an exogenous Cdk1 conferring sensitivity to one ATP analogue inhibitor (1NMPP1) and resistance to another (RO3306).	Adenosine Triphosphate	107-110	cyclin dependent kinase 1	Homo sapiens	49-53
23525902-5	2013	We rescued cells lethally depleted of endogenous Cdk1 with an exogenous Cdk1 conferring sensitivity to one ATP analogue inhibitor (1NMPP1) and resistance to another (RO3306).	Adenosine Triphosphate	107-110	cyclin dependent kinase 1	Homo sapiens	72-76
23525902-5	2013	We rescued cells lethally depleted of endogenous Cdk1 with an exogenous Cdk1 conferring sensitivity to one ATP analogue inhibitor (1NMPP1) and resistance to another (RO3306).	RO 3306	166-172	cyclin dependent kinase 1	Homo sapiens	49-53
23720738-11	2013	These data suggest that the phosphorylation of MCM7 on Ser-121 by cyclin/Cdks is involved in preventing DNA rereplication as well as in regulation of the mitotic exit.	Serine	55-58	cyclin dependent kinase 1	Homo sapiens	73-77
23692869-0	2013	DNA synthesis inhibition in response to benzo[a]pyrene dihydrodiol epoxide is associated with attenuation of p(34)cdc2: Role of p53.	benzo[a]pyrene dihydrodiol epoxide	40-74	cyclin dependent kinase 1	Homo sapiens	109-118
23525902-5	2013	We rescued cells lethally depleted of endogenous Cdk1 with an exogenous Cdk1 conferring sensitivity to one ATP analogue inhibitor (1NMPP1) and resistance to another (RO3306).	RO 3306	166-172	cyclin dependent kinase 1	Homo sapiens	72-76
23525902-7	2013	We also rescued RO3306-resistant clones using exogenous Cdk1 without inhibitory phosphorylation sites, indicating that the mitotic surge of Cdk1 activity is dispensable for cell proliferation.	RO 3306	16-22	cyclin dependent kinase 1	Homo sapiens	56-60
23525902-7	2013	We also rescued RO3306-resistant clones using exogenous Cdk1 without inhibitory phosphorylation sites, indicating that the mitotic surge of Cdk1 activity is dispensable for cell proliferation.	RO 3306	16-22	cyclin dependent kinase 1	Homo sapiens	140-144
23692869-3	2013	BPDE treatment of cells significantly attenuates expression of p(34)cdc2, a cell cycle activating protein.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	0-4	cyclin dependent kinase 1	Homo sapiens	63-72
23692869-5	2013	Unlike p53 accumulation, there is a correspondence between DNA synthesis/cell growth inhibition and cdc2 down-regulation by BPDE.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	124-128	cyclin dependent kinase 1	Homo sapiens	100-104
23692869-6	2013	BPDE-induced cdc2 down-regulation is p53 dependent, although there is no correspondence between p53 accumulation and cdc2 down-regulation.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	0-4	cyclin dependent kinase 1	Homo sapiens	13-17
23692869-7	2013	BPDE-induced cdc2 down-regulation corresponded with accumulation of the cell cycle inhibitor protein p21 (transactivation product of p53).	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	0-4	cyclin dependent kinase 1	Homo sapiens	13-17
23567337-7	2013	The protein effectively activates cdk1/cyclin B prokinase complexes in vitro in the absence of cdk1 kinase activity in an orthovanadate sensitive manner but is inactivated by A-kinase phosphorylation.	Vanadates	122-135	cyclin dependent kinase 1	Homo sapiens	34-38
23471882-0	2013	Millepachine, a novel chalcone, induces G2/M arrest by inhibiting CDK1 activity and causing apoptosis via ROS-mitochondrial apoptotic pathway in human hepatocarcinoma cells in vitro and in vivo.	millepachine	0-12	cyclin dependent kinase 1	Homo sapiens	66-70
23799914-0	2013	Sulforaphane induced cell cycle arrest in the G2/M phase via the blockade of cyclin B1/CDC2 in human ovarian cancer cells.	sulforaphane	0-12	cyclin dependent kinase 1	Homo sapiens	87-91
23425217-11	2013	These effects were caused by paeonol suppression of phosphorylation of cycle protein cdc2 and of CDK2.	paeonol	29-36	cyclin dependent kinase 1	Homo sapiens	85-89
23567243-7	2013	Meanwhile, the alterations of cyclin A and B1, p-CDK1 and p-cdc25c levels were also observed in response to DICO treatment.	Hydrocodone	108-112	cyclin dependent kinase 1	Homo sapiens	49-53
23686257-11	2013	In addition, genistein caused cell cycle arrest in the G2/M phase, which was accompanied by activation of ATM/p53, p21waf1/cip1 and GADD45alpha as well as downregulation of cdc2 and cdc25A demonstrated by q-PCR and immunoblotting assay.	Genistein	13-22	cyclin dependent kinase 1	Homo sapiens	173-177
23480292-6	2013	Significant decrease in the expression of cyclins A, B1, D1 and D2 and cyclin-dependent kinases (Cdk)s Cdk1 (Cdc2), Cdk2, Cdk4 and Cdk6 and an upregulated expression of cyclin-dependent kinase (CDK) inhibitor Cip1/p21 were found in alpha-santalol pretreated group.	a-santalol	232-246	cyclin dependent kinase 1	Homo sapiens	103-107
23799914-7	2013	SFN-treated cells accumulated in metaphase by CDC2 down-regulation and dissociation of the cyclin B1/CDC2 complex.	sulforaphane	0-3	cyclin dependent kinase 1	Homo sapiens	46-50
23799914-7	2013	SFN-treated cells accumulated in metaphase by CDC2 down-regulation and dissociation of the cyclin B1/CDC2 complex.	sulforaphane	0-3	cyclin dependent kinase 1	Homo sapiens	101-105
22797065-6	2013	We used Wee1 inhibition, using MK-1775, to force Cdk1 activation, which did not cause cytotoxicity in non-transformed cells.	adavosertib	31-38	cyclin dependent kinase 1	Homo sapiens	49-53
23360302-4	2013	Administration of the cdc2 inhibitor purvalanol A restricted compaction of the injury cavity and astrocyte infiltration into the cavity.	purvalanol B	37-47	cyclin dependent kinase 1	Homo sapiens	22-26
23775190-6	2013	We show that CDKN3 dephosphorylates threonine-161 of CDC2 during mitotic exit and we visualize CDC2(pThr-161) at kinetochores and centrosomes in early mitosis.	Threonine	36-45	cyclin dependent kinase 1	Homo sapiens	53-57
23775190-6	2013	We show that CDKN3 dephosphorylates threonine-161 of CDC2 during mitotic exit and we visualize CDC2(pThr-161) at kinetochores and centrosomes in early mitosis.	Threonine	36-45	cyclin dependent kinase 1	Homo sapiens	95-99
23775190-6	2013	We show that CDKN3 dephosphorylates threonine-161 of CDC2 during mitotic exit and we visualize CDC2(pThr-161) at kinetochores and centrosomes in early mitosis.	pthr	100-104	cyclin dependent kinase 1	Homo sapiens	53-57
23775190-6	2013	We show that CDKN3 dephosphorylates threonine-161 of CDC2 during mitotic exit and we visualize CDC2(pThr-161) at kinetochores and centrosomes in early mitosis.	pthr	100-104	cyclin dependent kinase 1	Homo sapiens	95-99
23825908-8	2013	Further biochemical studies showed that TBMS1-induced molecular events were related to mitochondria-induced intrinsic apoptosis and P21-cyclin B1/cdc2 complex-related G2/M cell cycle arrest.	tbms1	40-45	cyclin dependent kinase 1	Homo sapiens	146-150
23760496-9	2013	Olaparib, in combination with a selective CDK1 inhibitor or a pan HER inhibitor, is a potential new approach for treating breast cancer.	olaparib	0-8	cyclin dependent kinase 1	Homo sapiens	42-46
23591552-0	2013	Kaempferol induces autophagy through AMPK and AKT signaling molecules and causes G2/M arrest via downregulation of CDK1/cyclin B in SK-HEP-1 human hepatic cancer cells.	kaempferol	0-10	cyclin dependent kinase 1	Homo sapiens	115-119
23591552-7	2013	In SK-HEP-1 cells, kaempferol increased the protein levels of p-AMPK, LC3-II, Atg 5, Atg 7, Atg 12 and beclin 1 as well as inhibited the protein levels of CDK1, cyclin B, p-AKT and p-mTOR.	kaempferol	19-29	cyclin dependent kinase 1	Homo sapiens	155-159
23591552-8	2013	Taken together, CDK1/cyclin B expression and the AMPK and AKT signaling pathways contributed to kaempferol-induced G2/M cell cycle arrest and autophagic cell death in SK-HEP-1 human hepatic cancer cells.	kaempferol	96-106	cyclin dependent kinase 1	Homo sapiens	16-20
23628417-3	2013	BLU and paclitaxel induced cell cycle arrest in the G2/M phase through the reduction of cyclin dependent kinase 1, cyclin B1, while promoting both p16 and p27 expression.	Paclitaxel	8-18	cyclin dependent kinase 1	Homo sapiens	88-113
23597199-6	2013	The detailed in vitro and in vivo study on the molecular mechanisms of this compound demonstrated that IVHD-valtrate exposure modulated the expression of numerous molecules involved in cell cycle progression and apoptosis regardless of p53 status, leading to increase the level of p53, Rb, p21, p27 and decrease Mdm2, E2F1, Cyclin B1, Cdc25C and Cdc2.	valtrate	108-116	cyclin dependent kinase 1	Homo sapiens	335-339
23671119-2	2013	Phosphorylation of threonine 14 (T14) and tyrosine 15 (Y15) inhibits Cdks and regulates their activities in numerous physiologic contexts.	Threonine	19-28	cyclin dependent kinase 1	Homo sapiens	69-73
23671119-2	2013	Phosphorylation of threonine 14 (T14) and tyrosine 15 (Y15) inhibits Cdks and regulates their activities in numerous physiologic contexts.	Tyrosine	42-50	cyclin dependent kinase 1	Homo sapiens	69-73
23274058-0	2013	Jaceosidin, isolated from dietary mugwort (Artemisia princeps), induces G2/M cell cycle arrest by inactivating cdc25C-cdc2 via ATM-Chk1/2 activation.	jaceosidin	0-10	cyclin dependent kinase 1	Homo sapiens	111-115
23274058-5	2013	Jaceosidin induced G2/M phase cell cycle arrest and modulated the levels of cyclin B and p-Cdc2 in Hec1A cells.	jaceosidin	0-10	cyclin dependent kinase 1	Homo sapiens	91-95
23274058-10	2013	These data suggest that jaceosidin, isolated from Japanese mugwort, modulates the ERK/ATM/Chk1/2 pathway, leading to inactivation of the Cdc2-cyclin B1 complex, followed by G2/M cell cycle arrest in endometrial cancer cells.	jaceosidin	24-34	cyclin dependent kinase 1	Homo sapiens	137-141
23562365-7	2013	Treatment with EVn-50 or VB1 resulted in arresting the MDA-MB-435 and SMMC-7721 cells at G2/M phase, which was further supported by observations of increased phosphorylation of Histone 3 at Ser10, phosphorylation of Cdk1 at Tyr15, expression of cyclin B1, and decreased expression of Cdc25c.	evn-50	15-21	cyclin dependent kinase 1	Homo sapiens	216-220
23531881-4	2013	We find that persistent DDT recombination intermediates are largely resolved before anaphase through a G2/M damage checkpoint-independent, but Cdk1/Cdc5-dependent pathway that proceeds via a previously described Mus81-Mms4-activating phosphorylation.	DDT	24-27	cyclin dependent kinase 1	Homo sapiens	143-147
23602554-4	2013	Cyclin A2/CDK1 phosphorylates SAMHD1 at the Threonine 592 residue both in vitro and in vivo.	Threonine	44-53	cyclin dependent kinase 1	Homo sapiens	10-14
23620807-9	2013	Silica nanoparticles also induced G2/M arrest through the upregulation of Chk1 and the downregulation of Cdc25C, cyclin B1/Cdc2.	Silicon Dioxide	0-6	cyclin dependent kinase 1	Homo sapiens	105-109
23518499-5	2013	We showed that CDK1 function is required for all-trans retinoic acid (ATRA) to achieve the optimal effect in U-937 human leukemic cells.	Tretinoin	45-68	cyclin dependent kinase 1	Homo sapiens	15-19
23518499-5	2013	We showed that CDK1 function is required for all-trans retinoic acid (ATRA) to achieve the optimal effect in U-937 human leukemic cells.	Tretinoin	70-74	cyclin dependent kinase 1	Homo sapiens	15-19
23518499-6	2013	CDK1 modulates the levels of P27(kip) and AKT phosphorylation in response to ATRA treatment.	Tretinoin	77-81	cyclin dependent kinase 1	Homo sapiens	0-4
23518499-8	2013	The regulation of the subcellular content of CDK1 and RARgamma by ATRA is an important process for achieving an effective response in treatment of leukemia.	Tretinoin	66-70	cyclin dependent kinase 1	Homo sapiens	45-49
23518499-10	2013	In addition, expression of wee1 kinase and Cdc25A/C phosphatases also coincide with CDK1 expression and its subcellular localization in response to ATRA treatment.	Tretinoin	148-152	cyclin dependent kinase 1	Homo sapiens	84-88
23518499-11	2013	Our study reveals a novel mechanism by which CDK1 and RARgamma coordinate with ATRA to influence cell cycle progression and cellular differentiation.	Tretinoin	79-83	cyclin dependent kinase 1	Homo sapiens	45-49
23323858-9	2013	In addition, Thr(34) of survivin was shown to be the most important residue in determining survivin stability upon phosphorylation after HER2/Akt/CDK1 (cyclin-dependent kinase 1)-cyclin B1 signalling.	Threonine	13-16	cyclin dependent kinase 1	Homo sapiens	146-150
23500464-6	2013	We clarified that VCIP135, an essential factor in both p97 membrane fusion pathways, is phosphorylated on Threonine-760 and Serine-767 by Cdc2 at mitosis and that this phosphorylated VCIP135 does not bind to p97.	Threonine	106-115	cyclin dependent kinase 1	Homo sapiens	138-142
23500464-6	2013	We clarified that VCIP135, an essential factor in both p97 membrane fusion pathways, is phosphorylated on Threonine-760 and Serine-767 by Cdc2 at mitosis and that this phosphorylated VCIP135 does not bind to p97.	Serine	124-130	cyclin dependent kinase 1	Homo sapiens	138-142
22945332-5	2013	In our efforts to elucidate key molecular pathways underlying TCS and cell cycle escape, we have previously shown that the deregulation of mitotic kinase Cdk1 and its downstream effectors are important mediators of survival and cell cycle reentry.	9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide	62-65	cyclin dependent kinase 1	Homo sapiens	154-158
23399722-1	2013	A series of 2,9-substituted 6-guanidinopurines, structurally related to the cyclin-dependent kinase (CDK) inhibitors olomoucine and roscovitine, has been synthesized and characterized.	2,9-substituted 6-guanidinopurines	12-46	cyclin dependent kinase 1	Homo sapiens	101-104
23399722-1	2013	A series of 2,9-substituted 6-guanidinopurines, structurally related to the cyclin-dependent kinase (CDK) inhibitors olomoucine and roscovitine, has been synthesized and characterized.	olomoucine	117-127	cyclin dependent kinase 1	Homo sapiens	101-104
23399722-1	2013	A series of 2,9-substituted 6-guanidinopurines, structurally related to the cyclin-dependent kinase (CDK) inhibitors olomoucine and roscovitine, has been synthesized and characterized.	Roscovitine	132-143	cyclin dependent kinase 1	Homo sapiens	101-104
22945332-6	2013	We now report that aberrant expression of Cdk1 interferes with apoptosis and promotes the formation of polyploid senescent cells during TCS.	9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide	136-139	cyclin dependent kinase 1	Homo sapiens	42-46
22945332-8	2013	The Cdk1 pathway is in part modulated differentially by p21 and p27 two members of the KIP cyclin-dependent kinase inhibitor family during TCS.	9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide	139-142	cyclin dependent kinase 1	Homo sapiens	4-8
23314756-3	2013	Moreover, O-DMA             exposure at the IC50 concentration for 72 h arrested cells at the G2/M phase,             which was accompanied by a reduction in CDK1, and an increase in cyclin A and B.	O-desmethylangolensin	10-15	cyclin dependent kinase 1	Homo sapiens	158-162
23416073-6	2013	Indeed, cyclin B1-Cdk1 effectively phosphorylated MPP8 in vitro and on STA mutant of MPP8 (all possible sites phosphorylated by Cdk were substituted by alanine) failed to dissociate from chromatin during early mitosis.	Alanine	152-159	cyclin dependent kinase 1	Homo sapiens	18-22
23345399-4	2013	Two highly conserved hydrophobic residues surrounding the serine 670 Cdk1 phosphorylation site are required for B56 binding.	Serine	58-64	cyclin dependent kinase 1	Homo sapiens	69-73
22834967-10	2013	Butyrate (&gt; 2 mm) inhibited the expression of cdc2, cdc25C and cyclinB1 mRNAs and reduced the levels of Cdc2, Cdc25C and cyclinB1 proteins in GFs, as determined using RT-PCR and western blotting, respectively.	Butyrates	0-8	cyclin dependent kinase 1	Homo sapiens	49-53
23397083-6	2013	This was associated with upregulated checkpoint kinase (CHK2) expression and reduced CDC2 activity (i.e., increased phosphorylation of CDC2 on Tyr-15 and decreased phosphorylation of CDC2 on Thr-161).	Tyrosine	143-146	cyclin dependent kinase 1	Homo sapiens	135-139
23397083-6	2013	This was associated with upregulated checkpoint kinase (CHK2) expression and reduced CDC2 activity (i.e., increased phosphorylation of CDC2 on Tyr-15 and decreased phosphorylation of CDC2 on Thr-161).	Tyrosine	143-146	cyclin dependent kinase 1	Homo sapiens	135-139
23264621-0	2013	Cdk1 protein-mediated phosphorylation of receptor-associated protein 80 (RAP80) serine 677 modulates DNA damage-induced G2/M checkpoint and cell survival.	Serine	80-86	cyclin dependent kinase 1	Homo sapiens	0-4
23264621-4	2013	In this study, we identified Cdk1 as a new RAP80-binding protein and demonstrated that the Cdk1-cyclin B(1) complex phosphorylates RAP80 at Ser-677 using an in vitro kinase assay and a phosphopeptide-specific antibody against phospho-Ser-677 of RAP80.	Serine	140-143	cyclin dependent kinase 1	Homo sapiens	29-33
23264621-4	2013	In this study, we identified Cdk1 as a new RAP80-binding protein and demonstrated that the Cdk1-cyclin B(1) complex phosphorylates RAP80 at Ser-677 using an in vitro kinase assay and a phosphopeptide-specific antibody against phospho-Ser-677 of RAP80.	Serine	140-143	cyclin dependent kinase 1	Homo sapiens	91-95
23264621-4	2013	In this study, we identified Cdk1 as a new RAP80-binding protein and demonstrated that the Cdk1-cyclin B(1) complex phosphorylates RAP80 at Ser-677 using an in vitro kinase assay and a phosphopeptide-specific antibody against phospho-Ser-677 of RAP80.	Serine	234-237	cyclin dependent kinase 1	Homo sapiens	29-33
23264621-4	2013	In this study, we identified Cdk1 as a new RAP80-binding protein and demonstrated that the Cdk1-cyclin B(1) complex phosphorylates RAP80 at Ser-677 using an in vitro kinase assay and a phosphopeptide-specific antibody against phospho-Ser-677 of RAP80.	Serine	234-237	cyclin dependent kinase 1	Homo sapiens	91-95
23160341-11	2013	OEL induced the phosphorylation of cdc2, a G(2)/M phase cyclin-dependent kinase, and decreased the expression of cyclin B1 required for progression through the G(2)/M phase in U87 cells.	1-oxoeudesm-11(13)-eno-12,8a-lactone	0-3	cyclin dependent kinase 1	Homo sapiens	35-39
22619007-5	2013	In mechanistic studies, Silibinin decreased the protein level of p34cdc2, which might be the possible molecular mechanism of Silibinin efficacy on the growth inhibition in SGC-7901 cells.	Silybin	24-33	cyclin dependent kinase 1	Homo sapiens	65-72
22619007-5	2013	In mechanistic studies, Silibinin decreased the protein level of p34cdc2, which might be the possible molecular mechanism of Silibinin efficacy on the growth inhibition in SGC-7901 cells.	Silybin	125-134	cyclin dependent kinase 1	Homo sapiens	65-72
23264621-5	2013	RAP80 Ser-677 phosphorylation occurred in the M phase of the cell cycle when Cdk1 was in an active state.	Serine	6-9	cyclin dependent kinase 1	Homo sapiens	77-81
22834967-10	2013	Butyrate (&gt; 2 mm) inhibited the expression of cdc2, cdc25C and cyclinB1 mRNAs and reduced the levels of Cdc2, Cdc25C and cyclinB1 proteins in GFs, as determined using RT-PCR and western blotting, respectively.	Butyrates	0-8	cyclin dependent kinase 1	Homo sapiens	107-111
23343191-8	2013	Furthermore, doxorubicin alone greatly induced COX-2, a NF-kappaB target and Cdk-1, a target of P276-00, which was downregulated by P276-00 in the combination.	Doxorubicin	13-24	cyclin dependent kinase 1	Homo sapiens	77-82
23233035-5	2013	Furthermore, Smh-3 inhibited CDK1 activity, mitochondrial membrane potential (DeltaPsim) and increased the cytosolic Ca(2+) release and caspase-4, caspase-9 and caspase-3 activities in Hep3B cells.	smh-3	13-18	cyclin dependent kinase 1	Homo sapiens	29-33
23220710-6	2013	The reduction in expression of cyclin B1 protein and the increased activity of reactive oxygen species were observed in BGC823 cells treated with 12-deoxyphorbol 13-palmitate for 24 h. In addition, we found down-regulation of cdc2/cyclin B, cyclin A and p-chk1 in tumor cells.	12-deoxyphorbol 13-palmitate	146-174	cyclin dependent kinase 1	Homo sapiens	226-230
23434831-4	2013	Transfection of cells with dominant-negative Ras (RasN17) mutant genes up-regulated asperolide A-induced the decrease of cyclin B1 and CDC2, suppressed Raf, ERK activity and p53-p21 expression, and at last, abolished G2/M arrest.	asperolide A	84-96	cyclin dependent kinase 1	Homo sapiens	135-139
22086611-7	2013	However, quercetin-3-methyl ether caused a pronounced G(2)/M block mainly through the Chk1-Cdc25c-cyclin B1/Cdk1 pathway in lapatinib-sensitive and -resistant cells.	quercetin 3-O-methyl ether	9-33	cyclin dependent kinase 1	Homo sapiens	108-112
22086611-7	2013	However, quercetin-3-methyl ether caused a pronounced G(2)/M block mainly through the Chk1-Cdc25c-cyclin B1/Cdk1 pathway in lapatinib-sensitive and -resistant cells.	Lapatinib	124-133	cyclin dependent kinase 1	Homo sapiens	108-112
23220710-6	2013	The reduction in expression of cyclin B1 protein and the increased activity of reactive oxygen species were observed in BGC823 cells treated with 12-deoxyphorbol 13-palmitate for 24 h. In addition, we found down-regulation of cdc2/cyclin B, cyclin A and p-chk1 in tumor cells.	Reactive Oxygen Species	79-102	cyclin dependent kinase 1	Homo sapiens	226-230
23434831-3	2013	Moreover, asperolide A significantly activated MAP kinases (ERK1/2, JNK and p38 MAP kinase) by phosphorylation, and only the inhibition of ERK activation by PD98059 reversed downregulation of G2/M regulatory proteins CDC2, and suppressed upregulation of p21 and p-p53 levels.	asperolide	10-20	cyclin dependent kinase 1	Homo sapiens	217-221
23348582-5	2013	In addition, active recombinant Cdk1-cyclin B1 directly phosphorylates PTP1B at serine 386 in a kinase assay.	Serine	80-86	cyclin dependent kinase 1	Homo sapiens	32-36
23348582-6	2013	Recombinant Plk1 phosphorylates PTP1B on serine 286 and 393 in vitro, however, it requires a priming phosphorylation by Cdk1 at serine 386 highlighting a novel co-operation between Cdk1 and Plk1 in the regulation of PTP1B.	Serine	128-134	cyclin dependent kinase 1	Homo sapiens	120-124
23343191-10	2013	CONCLUSION: These findings suggest that this combination may increase the therapeutic index over doxorubicin alone and reduce systemic toxicity of doxorubicin most likely via an inhibition of doxorubicin-induced chemoresistance involving NF-kappaB signaling and inhibition of Cdk-1 which is involved in cell cycle progression.	Doxorubicin	97-108	cyclin dependent kinase 1	Homo sapiens	276-281
23343191-10	2013	CONCLUSION: These findings suggest that this combination may increase the therapeutic index over doxorubicin alone and reduce systemic toxicity of doxorubicin most likely via an inhibition of doxorubicin-induced chemoresistance involving NF-kappaB signaling and inhibition of Cdk-1 which is involved in cell cycle progression.	Doxorubicin	147-158	cyclin dependent kinase 1	Homo sapiens	276-281
23343191-10	2013	CONCLUSION: These findings suggest that this combination may increase the therapeutic index over doxorubicin alone and reduce systemic toxicity of doxorubicin most likely via an inhibition of doxorubicin-induced chemoresistance involving NF-kappaB signaling and inhibition of Cdk-1 which is involved in cell cycle progression.	Doxorubicin	147-158	cyclin dependent kinase 1	Homo sapiens	276-281
23321516-0	2013	Androgen receptor phosphorylation at serine 515 by Cdk1 predicts biochemical relapse in prostate cancer patients.	Serine	37-43	cyclin dependent kinase 1	Homo sapiens	51-55
23321516-11	2013	CONCLUSION: In prostate cancer patients with PSA at diagnosis of &lt;=20 ng ml(-1), phosphorylation of AR at serine 515 by Cdk1 may be an independent prognostic marker.	Serine	109-115	cyclin dependent kinase 1	Homo sapiens	123-127
23344197-6	2013	Cyclin-dependent kinase (cdk) 2 and cdc2 was also decreased after chamaejasmine treatment.	chamaejasmine	66-79	cyclin dependent kinase 1	Homo sapiens	36-40
23064420-9	2013	Casticin inhibited phosphorylation of the FOXO3a             protein and decreased the expression of FoxM1 and its downstream genes, such as             cyclin-dependent kinase (CDK1), cdc25B and cyclin B and increased the expression             of p27KIP1.	casticin	0-8	cyclin dependent kinase 1	Homo sapiens	178-182
23117090-4	2013	Flow cytometric analysis revealed that germacrone induced G2/M arrest in the cell cycle progression that was associated with an obvious decrease in the protein expression of cyclin B1 and its activating partner CDK1 with concomitant inductions of p21.	germacrone	39-49	cyclin dependent kinase 1	Homo sapiens	211-215
23432582-0	2013	Bisacylimidoselenocarbamates cause G2/M arrest associated with the modulation of CDK1 and Chk2 in human breast cancer MCF-7 cells.	bisacylimidoselenocarbamate	0-28	cyclin dependent kinase 1	Homo sapiens	81-85
24053672-2	2013	The inhibitory effect of genistein on cell proliferation is associated with G2/M cell cycle arrest and inhibition of cdc2 activities.	Genistein	25-34	cyclin dependent kinase 1	Homo sapiens	117-121
24053672-8	2013	Downregulation of PTEN by siRNA in genistein-treated cells increased phospho-Wee1 (Ser642), whereas decreased phospho-Cdc2 (Tyr15), resulting in decreased the G2/M cell cycle arrest.	Genistein	35-44	cyclin dependent kinase 1	Homo sapiens	118-122
23053255-1	2012	PURPOSE: Dinaciclib, a selective inhibitor of cyclin-dependent kinase (CDK) 1, CDK2, CDK5, and CDK9, is metabolized via CYP3A4.	dinaciclib	9-19	cyclin dependent kinase 1	Homo sapiens	46-77
23437041-8	2013	The expression of cell cycle genes, cdc2, PRC1 and PCNA and one of transcription factors that control the expression of these genes - nuclear respiratory factor-1 (NRF-1) was significantly up-regulated during the 4-OH-E2-mediated malignant transformation process.	4-hydroxyestradiol	213-220	cyclin dependent kinase 1	Homo sapiens	36-40
23437041-10	2013	These results indicate that 4-OH-E2-induced cell transformation may be mediated, in part, through redox-sensitive AKT signal transduction pathways by up-regulating the expression of cell cycle genes cdc2, PRC1 and PCNA, and the transcription factor - NRF-1.	4-hydroxyestradiol	28-35	cyclin dependent kinase 1	Homo sapiens	199-203
23359652-7	2013	SB225002-induced mitotic catastrophe appeared to be mediated by down-regulation of checkpoint kinase Chk1 and Cdk1-cyclin B activation.	SB 225002	0-8	cyclin dependent kinase 1	Homo sapiens	110-114
22982242-6	2012	We also found that inactive Cdk1 is caused by the sustained inactivation of CDC25B, which removes the inhibitory phosphate from Cdk1.	Phosphates	113-122	cyclin dependent kinase 1	Homo sapiens	28-32
22982242-6	2012	We also found that inactive Cdk1 is caused by the sustained inactivation of CDC25B, which removes the inhibitory phosphate from Cdk1.	Phosphates	113-122	cyclin dependent kinase 1	Homo sapiens	128-132
23063527-4	2012	Mass spectrometry, molecular, and cellular approaches show that CDK1/Cyclin B1 phosphorylates Gravin on threonine 766 to prime the recruitment of the polo-like kinase Plk1 at defined phases of mitosis.	Threonine	104-113	cyclin dependent kinase 1	Homo sapiens	64-68
23106301-8	2012	Nadroparin in A549 culture inhibited cyclin B1, Cdk1, Cdc25C and p-Cdc25C, while levels of p-Cdk1 were elevated; p21 expression was not altered.	Nadroparin	0-10	cyclin dependent kinase 1	Homo sapiens	48-52
22962408-12	2012	Lastly, pC treatment of EPCs caused cells to accumulate in the G2/M phase of the cell cycle with accompanied down-regulation of cyclin B1 and phosphorylated CDK1.	4-cresol	8-10	cyclin dependent kinase 1	Homo sapiens	157-161
22965228-5	2012	We show that when treated with Taxol, slippage-resistant HT29 colon carcinoma cells display robust Cdk1 activity and extensive Mcl-1/Bcl-x(L) phosphorylation and die in mitosis, whereas slippage-prone DLD-1 colon carcinoma cells display weak Cdk1 activity and partial and transient Mcl-1/Bcl-x(L) phosphorylation and die in subsequent interphase or survive.	Paclitaxel	31-36	cyclin dependent kinase 1	Homo sapiens	99-103
23351311-5	2012	Other study reported that genistein isolated from Glycine max seed inhibited phosphorylation of cdk1, gene involved during G2/M transition and thus could function as G2 checkpoint abrogator.	Genistein	26-35	cyclin dependent kinase 1	Homo sapiens	96-100
23351311-6	2012	The inhibition of cdk1 phosphorylation is one of alternative strategy which could selectively kill cancer cells and potentially be combined with DNA damaging agent such as curcumin.	Curcumin	172-180	cyclin dependent kinase 1	Homo sapiens	18-22
22795803-0	2012	AZD5438, an inhibitor of Cdk1, 2, and 9, enhances the radiosensitivity of non-small cell lung carcinoma cells.	AZD5438	0-7	cyclin dependent kinase 1	Homo sapiens	25-29
22795803-4	2012	METHODS AND MATERIALS: The combined effect of ionizing radiation and AZD5438, a highly specific inhibitor of Cdk1, 2, and 9, was determined in vitro by surviving fraction, cell cycle distribution, apoptosis, DNA double-strand break (DSB) repair, and homologous recombination (HR) assays in 3 NSCLC cell lines (A549, H1299, and H460).	AZD5438	69-76	cyclin dependent kinase 1	Homo sapiens	109-113
22266860-5	2012	Moreover, we showed that Sp1 is a novel mitotic substrate of CDK1/cyclin B1 and is phosphorylated by it at Thr 739 before the onset of mitosis.	Threonine	107-110	cyclin dependent kinase 1	Homo sapiens	61-65
22965228-5	2012	We show that when treated with Taxol, slippage-resistant HT29 colon carcinoma cells display robust Cdk1 activity and extensive Mcl-1/Bcl-x(L) phosphorylation and die in mitosis, whereas slippage-prone DLD-1 colon carcinoma cells display weak Cdk1 activity and partial and transient Mcl-1/Bcl-x(L) phosphorylation and die in subsequent interphase or survive.	Paclitaxel	31-36	cyclin dependent kinase 1	Homo sapiens	242-246
22536785-5	2012	Mechanistically, the DOX-induced G2/M phase cell cycle arrest and the decrease in cyclinB and cdc2 expression were not affected by melatonin.	Doxorubicin	21-24	cyclin dependent kinase 1	Homo sapiens	94-98
22730174-2	2012	The detailed molecular mechanism underlying the As(2)O(3)-induced inactivation of the cdc2 and possible functional role of PTEN in the observed G2/M arrest has yet to be elucidated.	(2)o(3)	50-57	cyclin dependent kinase 1	Homo sapiens	86-90
22730174-5	2012	The sustained G2/M arrest by As(2)O(3) is associated with decreased cdc2 protein and increased phospho-cdc2(Tyr15).	Arsenic Trioxide	29-38	cyclin dependent kinase 1	Homo sapiens	68-72
22730174-5	2012	The sustained G2/M arrest by As(2)O(3) is associated with decreased cdc2 protein and increased phospho-cdc2(Tyr15).	Arsenic Trioxide	29-38	cyclin dependent kinase 1	Homo sapiens	103-107
22730174-8	2012	Downregulation of PTEN by siRNA in As(2)O(3) -treated cells increased phospho-Wee1(Ser642) while decreased phospho-cdc2(Tyr15), resulting in decreased the G2/M cell cycle arrest.	(2)o(3)	37-44	cyclin dependent kinase 1	Homo sapiens	115-119
22784093-7	2012	We have identified KIBRA Ser(542) and Ser(931) as main phosphorylation sites for CDK1 both in vitro and in vivo.	Serine	25-28	cyclin dependent kinase 1	Homo sapiens	81-85
22841670-5	2012	Further mechanistic studies revealed that bufotalin treatment induced cell cycle arrest at G(2)/M phase through down-regulation of Aurora A, CDC25, CDK1, cyclin A and cyclin B1, as well as up-regulation of p53 and p21.	bufotalin	42-51	cyclin dependent kinase 1	Homo sapiens	148-152
22784093-7	2012	We have identified KIBRA Ser(542) and Ser(931) as main phosphorylation sites for CDK1 both in vitro and in vivo.	Serine	38-41	cyclin dependent kinase 1	Homo sapiens	81-85
22821149-2	2012	BAY 1000394 inhibits the activity of cell-cycle CDKs CDK1, CDK2, CDK3, CDK4, and of transcriptional CDKs CDK7 and CDK9 with IC(50) values in the range between 5 and 25 nmol/L.	roniciclib	0-11	cyclin dependent kinase 1	Homo sapiens	48-52
22858649-4	2012	In addition, bufalin induced G2/M phase arrest by reducing CDK1 activity.	bufalin	13-20	cyclin dependent kinase 1	Homo sapiens	59-63
22996593-11	2012	Energetic analysis reveals that van der Waals interaction and non-polar contributions to solvent are favorable in the formation of complexes and amine group of the ligand, which plays a crucial role for binding selectivity between CDK2 and CDK1.	Amines	145-150	cyclin dependent kinase 1	Homo sapiens	240-244
22821149-2	2012	BAY 1000394 inhibits the activity of cell-cycle CDKs CDK1, CDK2, CDK3, CDK4, and of transcriptional CDKs CDK7 and CDK9 with IC(50) values in the range between 5 and 25 nmol/L.	roniciclib	0-11	cyclin dependent kinase 1	Homo sapiens	53-57
22821149-2	2012	BAY 1000394 inhibits the activity of cell-cycle CDKs CDK1, CDK2, CDK3, CDK4, and of transcriptional CDKs CDK7 and CDK9 with IC(50) values in the range between 5 and 25 nmol/L.	roniciclib	0-11	cyclin dependent kinase 1	Homo sapiens	100-104
22828439-4	2012	In addition, calactin treatment showed that a decrease in the expression of cell cycle regulatory proteins Cyclin B1, Cdk1, and Cdc25C was consistent with a G2/M phase arrest.	Calactin	13-21	cyclin dependent kinase 1	Homo sapiens	118-122
22778260-8	2012	In vitro phosphorylation assays and phosphopeptide competition experiments revealed a phosphorylation at Ser-270 depending on enzyme activities of cyclin-dependent kinases CDK1, -2, or -5.	Serine	105-108	cyclin dependent kinase 1	Homo sapiens	172-176
22969238-13	2012	DFOG decreased the expression of FOXM1 and its downstream genes, such as CDK1, Cdc25B, cyclin B, and increased p27(KIP1) at protein levels.	7-difluoromethoxyl-5,4'-di-n-octylgenistein	0-4	cyclin dependent kinase 1	Homo sapiens	73-77
22683510-4	2012	Treatment of U87 cells with 1.0muM CIL-102 resulted in phosphorylation of extracellular signal-related kinase (ERK1/2), downregulation of cell cycle-related proteins (cyclin A, cyclin B, cyclin D1, and cdk1), and phosphorylation of cdk1Tyr(15) and Cdc25cSer(216).	1-(4-(furo(2,3-b)quinolin-4-ylamino)phenyl)ethanone	35-42	cyclin dependent kinase 1	Homo sapiens	202-206
22407595-13	2012	Serine 71 of Ubc9 was required for phosphorylation, interaction with Cdc2, and protein stability.	Serine	0-6	cyclin dependent kinase 1	Homo sapiens	69-73
22486746-11	2012	CONCLUSIONS: Triethylene glycol dimethacrylate induced cytotoxicity, cell cycle arrest and apoptosis in dental pulp cells, which was associated with the decline of cdc2, cyclin B1, cdc25C expression and elevation of p21 expression.	triethylene glycol dimethacrylate	13-46	cyclin dependent kinase 1	Homo sapiens	164-168
22683510-4	2012	Treatment of U87 cells with 1.0muM CIL-102 resulted in phosphorylation of extracellular signal-related kinase (ERK1/2), downregulation of cell cycle-related proteins (cyclin A, cyclin B, cyclin D1, and cdk1), and phosphorylation of cdk1Tyr(15) and Cdc25cSer(216).	1-(4-(furo(2,3-b)quinolin-4-ylamino)phenyl)ethanone	35-42	cyclin dependent kinase 1	Homo sapiens	232-236
22683510-5	2012	Furthermore, treatment with the ERK1/2 inhibitor PD98059 abolished CIL-102-induced Cdc25cSer(216) expression and reversed CIL-102-inhibited cdk1 activation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	49-56	cyclin dependent kinase 1	Homo sapiens	140-144
22683510-5	2012	Furthermore, treatment with the ERK1/2 inhibitor PD98059 abolished CIL-102-induced Cdc25cSer(216) expression and reversed CIL-102-inhibited cdk1 activation.	1-(4-(furo(2,3-b)quinolin-4-ylamino)phenyl)ethanone	122-129	cyclin dependent kinase 1	Homo sapiens	140-144
22580043-0	2012	Critical role of cyclin B1/Cdc2 up-regulation in the induction of mitotic prometaphase arrest in human breast cancer cells treated with 2-methoxyestradiol.	2-Methoxyestradiol	136-154	cyclin dependent kinase 1	Homo sapiens	27-31
22753416-5	2012	This study demonstrates that Fry binds to polo-like kinase 1 (Plk1) through the polo-box domain of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation at Thr-2516.	Threonine	191-194	cyclin dependent kinase 1	Homo sapiens	133-158
22580043-6	2012	The 2ME(2)-induced prometaphase arrest is abrogated by selective knockdown of cyclin B1 and Cdc2, or by pre-treatment of cells with roscovitine, an inhibitor of cyclin-dependent kinases, or by co-treatment of cells with cycloheximide, a protein synthesis inhibitor that was found to suppress the early up-regulation of cyclin B1 and Cdc2.	Roscovitine	132-143	cyclin dependent kinase 1	Homo sapiens	333-337
21988060-8	2012	Coimmunoprecipitation further confirmed that there was an interaction between phosphorylation of ERK and cyclin D1, CDK4, cyclin B1, or CDK1, which was weaken in the presence of melatonin or PD98059.	Melatonin	178-187	cyclin dependent kinase 1	Homo sapiens	136-140
22797303-5	2012	We further demonstrated that CDK1 phosphorylates C/EBPalpha on serine 21, which inhibits its differentiation-inducing function.	Serine	63-69	cyclin dependent kinase 1	Homo sapiens	29-33
21988060-8	2012	Coimmunoprecipitation further confirmed that there was an interaction between phosphorylation of ERK and cyclin D1, CDK4, cyclin B1, or CDK1, which was weaken in the presence of melatonin or PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	191-198	cyclin dependent kinase 1	Homo sapiens	136-140
22552540-8	2012	Investigation of G2-M phase-related cell cycle proteins involved in the response to bortezomib revealed that the ataxia telangiectasia mutated (ATM)-cell cycle checkpoint kinase 1 (CHK1) pathway, but not ATM and Rad3-related (ATR), was activated, resulting in the inactivation of cdc2.	Bortezomib	84-94	cyclin dependent kinase 1	Homo sapiens	280-284
22328137-5	2012	Furthermore, combination (2-DG+6-AN+2 Gy) induced G2/M arrest is closely correlated to decreased cyclin A, cyclin B1, and cdc2 levels.	Deoxyglucose	26-30	cyclin dependent kinase 1	Homo sapiens	122-126
22328137-5	2012	Furthermore, combination (2-DG+6-AN+2 Gy) induced G2/M arrest is closely correlated to decreased cyclin A, cyclin B1, and cdc2 levels.	6-Aminonicotinamide	31-35	cyclin dependent kinase 1	Homo sapiens	122-126
22348919-7	2012	Notably, 5-epi-sinuleptolide up-regulated p53 and p21 expression and inhibited G2/M phase regulators of cyclin B1 and cyclin-dependent kinease 1 (CDK1) in SCC25 cells.	5-episinuleptolide	9-28	cyclin dependent kinase 1	Homo sapiens	118-144
22348919-7	2012	Notably, 5-epi-sinuleptolide up-regulated p53 and p21 expression and inhibited G2/M phase regulators of cyclin B1 and cyclin-dependent kinease 1 (CDK1) in SCC25 cells.	5-episinuleptolide	9-28	cyclin dependent kinase 1	Homo sapiens	146-150
22382785-6	2012	Moreover, we found that t-AUCB induces cell-cycle G0/G1 phase arrest by regulating Cyclin D1 mRNA and protein levels and CDC2 (Thr161) phosphorylation level.	4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid	24-30	cyclin dependent kinase 1	Homo sapiens	121-125
22665354-7	2012	Furthermore, capsaicin suppressed the cell cycle progression at the G1/S phase in FaDu cells by decreasing the expression of the regulators of cyclin B1 and D1, as well as cyclin-dependent protein kinases cdk-1, cdk-2 and cdk-4.	Capsaicin	13-22	cyclin dependent kinase 1	Homo sapiens	205-210
22622012-6	2012	The preferable hits obtained were further docked into ATP binding site of CDK1, and nine promising compounds were retrieved as novel potential CDK1 inhibitors for further studies.	Adenosine Triphosphate	54-57	cyclin dependent kinase 1	Homo sapiens	74-78
22622012-6	2012	The preferable hits obtained were further docked into ATP binding site of CDK1, and nine promising compounds were retrieved as novel potential CDK1 inhibitors for further studies.	Adenosine Triphosphate	54-57	cyclin dependent kinase 1	Homo sapiens	143-147
22551018-5	2012	The ribose binding pocket of CHK1 was targeted to generate inhibitors with excellent cellular potency and selectivity over CDK1and IKKbeta, key features lacking from the initial compounds.	Ribose	4-10	cyclin dependent kinase 1	Homo sapiens	123-127
22634579-8	2012	KEY FINDINGS: The results showed that non-toxic concentrations of andrographolide inhibited the proliferation of human glioblastoma cells through induction of G2/M arrest, which was accompanied by down-regulating Cdk1 and Cdc25C proteins.	andrographolide	66-81	cyclin dependent kinase 1	Homo sapiens	213-217
22266097-6	2012	TCDD inactivated Akt-FoxO3a pathway, increased cdc25C/cdc2 activity, decreased P21/P27 activity, and enriched G2/M phase, in a PR- and AhR-dependent manner.	Polychlorinated Dibenzodioxins	0-4	cyclin dependent kinase 1	Homo sapiens	47-51
22607669-2	2012	This series derived from a pyrazolopyrimidine series previously reported as inhibitors of aurora kinases and CDKs.	1H-pyrazolo[4,3-d]pyrimidine	27-45	cyclin dependent kinase 1	Homo sapiens	109-113
22607669-5	2012	The synthesis of the new series of pyrrolopyrimidine analogs relied on the development of a different route for the two key intermediates 7 and 19 which led to analogs with both tunable activity against CDK1 and maintained cell potency.	pyrrolopyrimidine	35-52	cyclin dependent kinase 1	Homo sapiens	203-207
22802695-4	2012	Western blotting on the expression of cell cycle inhibitors showed that p21 and p27 was up-regulated as ethanol concentration increases from 0 to 1.5% whilst the cell cycle regulators, cdk1, cdk2, and cdk4 as well as Cyclin A, Cyclin B1 and Cyclin E1, were gradually down-regulated.	Ethanol	104-111	cyclin dependent kinase 1	Homo sapiens	185-189
22371530-7	2012	Then neurite outgrowth was suppressed by genetic depletion of phospho-vimentin and beta1 integrin as well as inhibition of vimentin phosphorylation by Cdc2 inhibitor purvalanol A.	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	166-178	cyclin dependent kinase 1	Homo sapiens	151-155
22580740-10	2012	Furthermore, the treatment of MG63/DOX cells with THP (200-1000 ng/mL) downregulated cyclin B1 expression, and decreased the phosphorylated Cdc2 at Thr(161).	Doxorubicin	35-38	cyclin dependent kinase 1	Homo sapiens	140-144
22580740-10	2012	Furthermore, the treatment of MG63/DOX cells with THP (200-1000 ng/mL) downregulated cyclin B1 expression, and decreased the phosphorylated Cdc2 at Thr(161).	pirarubicin	50-53	cyclin dependent kinase 1	Homo sapiens	140-144
22580740-10	2012	Furthermore, the treatment of MG63/DOX cells with THP (200-1000 ng/mL) downregulated cyclin B1 expression, and decreased the phosphorylated Cdc2 at Thr(161).	Threonine	148-151	cyclin dependent kinase 1	Homo sapiens	140-144
22580740-11	2012	Conversely, the treatment increased the phosphorylated Cdc2 at Thr(14)/Tyr(15) and Cdc25C at Ser(216), which led to a decrease in Cdc2-cyclin B1 activity.	Threonine	63-66	cyclin dependent kinase 1	Homo sapiens	55-59
22580740-11	2012	Conversely, the treatment increased the phosphorylated Cdc2 at Thr(14)/Tyr(15) and Cdc25C at Ser(216), which led to a decrease in Cdc2-cyclin B1 activity.	Tyrosine	71-74	cyclin dependent kinase 1	Homo sapiens	55-59
22580740-11	2012	Conversely, the treatment increased the phosphorylated Cdc2 at Thr(14)/Tyr(15) and Cdc25C at Ser(216), which led to a decrease in Cdc2-cyclin B1 activity.	Serine	93-96	cyclin dependent kinase 1	Homo sapiens	55-59
22580740-11	2012	Conversely, the treatment increased the phosphorylated Cdc2 at Thr(14)/Tyr(15) and Cdc25C at Ser(216), which led to a decrease in Cdc2-cyclin B1 activity.	Serine	93-96	cyclin dependent kinase 1	Homo sapiens	83-87
22094936-0	2012	High miR-26a and low CDC2 levels associate with decreased EZH2 expression and with favorable outcome on tamoxifen in metastatic breast cancer.	Tamoxifen	104-113	cyclin dependent kinase 1	Homo sapiens	21-25
22094936-9	2012	Multivariate analysis revealed miR-26a and CDC2 as an optimal set of markers associated with outcome on tamoxifen therapy, independently of traditional predictive factors.	Tamoxifen	104-113	cyclin dependent kinase 1	Homo sapiens	43-47
21331744-5	2012	While A2780 cells were arrested in G(2)/M phase with CDKI-83 treatment, phosphorylation at Thr(320) of PP1alpha was significantly reduced, indicating CDK1 inhibition.	Threonine	91-94	cyclin dependent kinase 1	Homo sapiens	150-154
22378300-6	2012	By co-immunoprecipitation,             we demonstrated that Mcl1 associated with PCNA and CDK1 in G2/M cell cycle arrest             in DADS-treated HL-60 cells.	diallyl disulfide	136-140	cyclin dependent kinase 1	Homo sapiens	90-94
22511751-8	2012	HIF-1alpha activation in human PAH leads to mitochondrial fission by cyclin B1/CDK1-dependent phosphorylation of DRP1 at serine 616.	Serine	121-127	cyclin dependent kinase 1	Homo sapiens	79-83
22378300-4	2012	We demonstrated that DADS treatment significantly increased             the proportion of G2/M phase HL-60 cells (P&lt;0.05) and caused a time-dependent             significant downregulation of Mcl1 and the cell cycle-related proteins PCNA and             CDK1 (P&lt;0.05).	diallyl disulfide	21-25	cyclin dependent kinase 1	Homo sapiens	257-261
22407961-4	2012	Nocodazole or vinblastine-induced MT depolymerization abrogated the stathmin-depletion induced G2 delay, measured by the percentage of cells staining positive for several markers (TPX2, CDK1 with inhibitory phosphorylation), indicating that MTs are required to lengthen G2.	Nocodazole	0-10	cyclin dependent kinase 1	Homo sapiens	186-190
22407961-4	2012	Nocodazole or vinblastine-induced MT depolymerization abrogated the stathmin-depletion induced G2 delay, measured by the percentage of cells staining positive for several markers (TPX2, CDK1 with inhibitory phosphorylation), indicating that MTs are required to lengthen G2.	Vinblastine	14-25	cyclin dependent kinase 1	Homo sapiens	186-190
20946258-6	2012	RESULTS: Under high glucose conditions, simvastatin dose-dependently inhibited VSMC migration, decreased PI3K/Akt pathway activity, reduced c-Raf and Ras expression, increased RhoB but not RhoA, Rac1, and Cdc2 expression, dose-dependently inhibited MMP-2, but not MMP-9, activity, and dose-dependently inhibited NF-kappaB activity.	Simvastatin	40-51	cyclin dependent kinase 1	Homo sapiens	205-209
21821547-0	2012	Recurrence risk score based on the specific activity of CDK1 and CDK2 predicts response to neoadjuvant paclitaxel followed by 5-fluorouracil, epirubicin and cyclophosphamide in breast cancers.	Paclitaxel	103-113	cyclin dependent kinase 1	Homo sapiens	56-60
21821547-0	2012	Recurrence risk score based on the specific activity of CDK1 and CDK2 predicts response to neoadjuvant paclitaxel followed by 5-fluorouracil, epirubicin and cyclophosphamide in breast cancers.	Fluorouracil	126-140	cyclin dependent kinase 1	Homo sapiens	56-60
21821547-0	2012	Recurrence risk score based on the specific activity of CDK1 and CDK2 predicts response to neoadjuvant paclitaxel followed by 5-fluorouracil, epirubicin and cyclophosphamide in breast cancers.	Epirubicin	142-152	cyclin dependent kinase 1	Homo sapiens	56-60
21821547-0	2012	Recurrence risk score based on the specific activity of CDK1 and CDK2 predicts response to neoadjuvant paclitaxel followed by 5-fluorouracil, epirubicin and cyclophosphamide in breast cancers.	Cyclophosphamide	157-173	cyclin dependent kinase 1	Homo sapiens	56-60
21509526-5	2012	KX-01 induced nuclear accumulation of cyclin B1, and activation of CDK1, MPM2, and Cdc25C that is required for progression past the G2/M checkpoint.	kx2-391	0-5	cyclin dependent kinase 1	Homo sapiens	67-71
22147199-6	2012	Effect of DI on up-regulation of p21 expression and down-regulation of cyclin B1, p34(cdc2) expression in irradiated HeLa cell was concomitant with cell cycle arrest in G(2) phase.	di	10-12	cyclin dependent kinase 1	Homo sapiens	86-90
21543203-7	2012	We also observed that flavokawain B caused the G2/M phase arrest that was mediated through reductions in the levels of cyclin A, cyclin B1, Cdc2 and Cdc25C and increases in p21/WAF1, Wee1 and p53 levels.	flavokawain B	22-35	cyclin dependent kinase 1	Homo sapiens	140-144
22147197-7	2012	Furthermore, costunolide induced cell cycle arrest in the G2/M phase via decrease in Cdc2, cyclin B1 and increase in p21WAF1 expression, independent of p53 pathway in p53-mutant MDA-MB-231 cells and increases Cdc2-p21WAF1 binding.	costunolide	13-24	cyclin dependent kinase 1	Homo sapiens	85-89
22147197-7	2012	Furthermore, costunolide induced cell cycle arrest in the G2/M phase via decrease in Cdc2, cyclin B1 and increase in p21WAF1 expression, independent of p53 pathway in p53-mutant MDA-MB-231 cells and increases Cdc2-p21WAF1 binding.	costunolide	13-24	cyclin dependent kinase 1	Homo sapiens	209-213
22286776-8	2012	Under both oxygen tensions, Hsp90 inhibition downregulated the cell cycle-associated proteins, Cdk1, Cdk4 and pRb.	Oxygen	11-17	cyclin dependent kinase 1	Homo sapiens	95-99
22352892-1	2012	The screening of the ICSN chemical library on various disease-relevant protein kinases led to the identification of natural flavonoidal alkaloids of unknown configuration as potent inhibitors of the CDK1 and CDK5 kinases.	flavonoidal alkaloids	124-145	cyclin dependent kinase 1	Homo sapiens	199-203
22275373-8	2012	Finally, inhibition of CDK1 and CDK9 decreased AR Ser-81 phosphorylation, chromatin binding, and transcriptional activity.	Serine	50-53	cyclin dependent kinase 1	Homo sapiens	23-27
22275373-1	2012	Our previous findings indicated that androgen receptor (AR) phosphorylation at serine 81 is stimulated by the mitotic cyclin-dependent kinase 1 (CDK1).	Serine	79-85	cyclin dependent kinase 1	Homo sapiens	118-143
22275373-9	2012	These findings indicate that Ser-81 phosphorylation by CDK9 stabilizes AR chromatin binding for transcription and suggest that CDK1-mediated Ser-81 phosphorylation during mitosis provides a pool of Ser-81 phosphorylation AR that can be readily recruited to chromatin for gene reactivation and may enhance AR activity in PCa.	Serine	29-32	cyclin dependent kinase 1	Homo sapiens	127-131
22275373-1	2012	Our previous findings indicated that androgen receptor (AR) phosphorylation at serine 81 is stimulated by the mitotic cyclin-dependent kinase 1 (CDK1).	Serine	79-85	cyclin dependent kinase 1	Homo sapiens	145-149
22275373-2	2012	In this report, we extended our previous study and confirmed that Ser-81 phosphorylation increases during mitosis, coincident with CDK1 activation.	Serine	66-69	cyclin dependent kinase 1	Homo sapiens	131-135
22275373-9	2012	These findings indicate that Ser-81 phosphorylation by CDK9 stabilizes AR chromatin binding for transcription and suggest that CDK1-mediated Ser-81 phosphorylation during mitosis provides a pool of Ser-81 phosphorylation AR that can be readily recruited to chromatin for gene reactivation and may enhance AR activity in PCa.	Serine	141-144	cyclin dependent kinase 1	Homo sapiens	127-131
22275373-9	2012	These findings indicate that Ser-81 phosphorylation by CDK9 stabilizes AR chromatin binding for transcription and suggest that CDK1-mediated Ser-81 phosphorylation during mitosis provides a pool of Ser-81 phosphorylation AR that can be readily recruited to chromatin for gene reactivation and may enhance AR activity in PCa.	Serine	141-144	cyclin dependent kinase 1	Homo sapiens	127-131
22326168-0	2012	Synthesis, SAR and biological evaluation of 1,6-disubstituted-1H-pyrazolo[3,4-d]pyrimidines as dual inhibitors of Aurora kinases and CDK1.	1,6-disubstituted-1h-pyrazolo[3,4-d]pyrimidines	44-91	cyclin dependent kinase 1	Homo sapiens	133-137
22230261-5	2012	ERK inhibitor PD98059 and p38 inhibitor SB203580 significantly reversed the depression of Cdc25C/p-Cdc25C, Cdc2/p-Cdc2, cyclinB1 as well as the cyclinB1-Cdc2 complex, thereby, abolished the delay in G2 phase.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	14-21	cyclin dependent kinase 1	Homo sapiens	90-94
22230261-5	2012	ERK inhibitor PD98059 and p38 inhibitor SB203580 significantly reversed the depression of Cdc25C/p-Cdc25C, Cdc2/p-Cdc2, cyclinB1 as well as the cyclinB1-Cdc2 complex, thereby, abolished the delay in G2 phase.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	14-21	cyclin dependent kinase 1	Homo sapiens	99-103
22230261-5	2012	ERK inhibitor PD98059 and p38 inhibitor SB203580 significantly reversed the depression of Cdc25C/p-Cdc25C, Cdc2/p-Cdc2, cyclinB1 as well as the cyclinB1-Cdc2 complex, thereby, abolished the delay in G2 phase.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	14-21	cyclin dependent kinase 1	Homo sapiens	99-103
22230261-5	2012	ERK inhibitor PD98059 and p38 inhibitor SB203580 significantly reversed the depression of Cdc25C/p-Cdc25C, Cdc2/p-Cdc2, cyclinB1 as well as the cyclinB1-Cdc2 complex, thereby, abolished the delay in G2 phase.	SB 203580	40-48	cyclin dependent kinase 1	Homo sapiens	90-94
22230261-5	2012	ERK inhibitor PD98059 and p38 inhibitor SB203580 significantly reversed the depression of Cdc25C/p-Cdc25C, Cdc2/p-Cdc2, cyclinB1 as well as the cyclinB1-Cdc2 complex, thereby, abolished the delay in G2 phase.	SB 203580	40-48	cyclin dependent kinase 1	Homo sapiens	99-103
22230261-5	2012	ERK inhibitor PD98059 and p38 inhibitor SB203580 significantly reversed the depression of Cdc25C/p-Cdc25C, Cdc2/p-Cdc2, cyclinB1 as well as the cyclinB1-Cdc2 complex, thereby, abolished the delay in G2 phase.	SB 203580	40-48	cyclin dependent kinase 1	Homo sapiens	99-103
22326168-2	2012	In addition to targeting these Aurora kinases involved in mitosis, CDK1 has been added as a primary inhibition target in hopes of enhancing the cytotoxicity of our chemotypes harboring the pyrazolopyrimidine core.	1H-pyrazolo[4,3-d]pyrimidine	189-207	cyclin dependent kinase 1	Homo sapiens	67-71
22326168-3	2012	SAR optimization of this series using the AKA, AKB and CDK1 biochemical assays led to the discovery of the compound 7h which combines strong potency against the 3 kinases with an acceptable microsomal stability.	7,8-diacetoxy-3-(4-nitrophenyl)coumarin	116-118	cyclin dependent kinase 1	Homo sapiens	55-59
22277074-3	2012	The results show that the 5-hydroxy-tetraindole 8 (SK228) has optimum antiproliferative activity against breast adenocarcinoma (MCF 7 and MDA-MB-231) cells and that this activity involves G(2)-phase arrest of the cell cycle with a distinctive increase in the expression of cyclin B1 and phospho-cdc2.	5-hydroxy-tetraindole 8	26-49	cyclin dependent kinase 1	Homo sapiens	295-299
22754657-4	2012	Not only is the inhibition of PP2A-B55 by phospho-endosulphine required to prevent dephosphorylation of Cdk1-CycB substrates until mitotic exit, but it is also required to promote Cdc25 activity and inhibit Wee1 at mitotic entry.	phospho-endosulphine	42-62	cyclin dependent kinase 1	Homo sapiens	104-108
22277074-3	2012	The results show that the 5-hydroxy-tetraindole 8 (SK228) has optimum antiproliferative activity against breast adenocarcinoma (MCF 7 and MDA-MB-231) cells and that this activity involves G(2)-phase arrest of the cell cycle with a distinctive increase in the expression of cyclin B1 and phospho-cdc2.	1,4-bis(di(5-hydroxy-1H-indol-3-yl)methyl)benzene	51-56	cyclin dependent kinase 1	Homo sapiens	295-299
22012316-2	2012	The results demonstrate that all of the three oxoanions can cause G(2)/M cell cycle arrest, which is evidenced by the increase in the level of phosphorylated Cdc2 at its inactive Tyr-15 site.	Tyrosine	179-182	cyclin dependent kinase 1	Homo sapiens	158-162
22223332-5	2012	To elucidate the mechanism of action, the effect of pycnidione on the signal transduction of the G2 checkpoint was analyzed, showing that the increased phospho-cyclin dependent kinase-1 (CDK1) level caused by bleomycin was abrogated in the presence of pycnidione, indicating that cells did not arrest at the G2 phase.	pycnidione	52-62	cyclin dependent kinase 1	Homo sapiens	187-191
21993600-6	2012	TSA also effectively arrested cell             cycle progression at the G2/M phase through the up-regulation of p21waf expression,             down-regulation of Cyclin B1 and reduction of the inhibitory phophorylation of             Cdc2.	trichostatin A	0-3	cyclin dependent kinase 1	Homo sapiens	234-238
22024133-7	2012	Mcl-1 phosphorylation closely paralleled cyclin B expression, and specific cyclin-dependent kinase (Cdk) inhibitors blocked vinblastine-induced Mcl-1 phosphorylation, its subsequent degradation, and improved cell viability after mitotic arrest.	Vinblastine	124-135	cyclin dependent kinase 1	Homo sapiens	100-103
22108589-6	2012	In addition, arecoline induced progressive and sustained accumulation of BCC-1/KMC cells in G2/M phase as a result of reducing checkpoint Cdc2 activity by decreasing Cdc25C phosphatase levels and increasing p53 levels.	Arecoline	13-22	cyclin dependent kinase 1	Homo sapiens	138-142
22223332-5	2012	To elucidate the mechanism of action, the effect of pycnidione on the signal transduction of the G2 checkpoint was analyzed, showing that the increased phospho-cyclin dependent kinase-1 (CDK1) level caused by bleomycin was abrogated in the presence of pycnidione, indicating that cells did not arrest at the G2 phase.	pycnidione	52-62	cyclin dependent kinase 1	Homo sapiens	152-185
21964263-7	2012	Phosphorylation (at serine 87) by Cdk1-Cln complexes primes Far1 for ubiquitin-mediated proteolysis.	Serine	20-26	cyclin dependent kinase 1	Homo sapiens	34-38
22223332-5	2012	To elucidate the mechanism of action, the effect of pycnidione on the signal transduction of the G2 checkpoint was analyzed, showing that the increased phospho-cyclin dependent kinase-1 (CDK1) level caused by bleomycin was abrogated in the presence of pycnidione, indicating that cells did not arrest at the G2 phase.	Bleomycin	209-218	cyclin dependent kinase 1	Homo sapiens	152-185
22223332-5	2012	To elucidate the mechanism of action, the effect of pycnidione on the signal transduction of the G2 checkpoint was analyzed, showing that the increased phospho-cyclin dependent kinase-1 (CDK1) level caused by bleomycin was abrogated in the presence of pycnidione, indicating that cells did not arrest at the G2 phase.	Bleomycin	209-218	cyclin dependent kinase 1	Homo sapiens	187-191
22223332-5	2012	To elucidate the mechanism of action, the effect of pycnidione on the signal transduction of the G2 checkpoint was analyzed, showing that the increased phospho-cyclin dependent kinase-1 (CDK1) level caused by bleomycin was abrogated in the presence of pycnidione, indicating that cells did not arrest at the G2 phase.	pycnidione	252-262	cyclin dependent kinase 1	Homo sapiens	152-185
22223332-5	2012	To elucidate the mechanism of action, the effect of pycnidione on the signal transduction of the G2 checkpoint was analyzed, showing that the increased phospho-cyclin dependent kinase-1 (CDK1) level caused by bleomycin was abrogated in the presence of pycnidione, indicating that cells did not arrest at the G2 phase.	pycnidione	252-262	cyclin dependent kinase 1	Homo sapiens	187-191
22719783-7	2012	Our findings revealed that levels of cyclin A, cyclin B1, and CDK1 were diminished; in contrast, levels of the negative cell cycle regulators p27(Kip1) and p21(Cip1) were increased in response to 6-gingerol treatment.	gingerol	196-206	cyclin dependent kinase 1	Homo sapiens	62-66
22719783-9	2012	These findings indicate that exposure of 6-gingerol may induce intracellular ROS and upregulate p53, p27(Kip1), and p21(Cip1) levels leading to consequent decrease of CDK1, cyclin A, and cyclin B1 as result of cell cycle arrest in LoVo cells.	gingerol	41-51	cyclin dependent kinase 1	Homo sapiens	167-171
21918011-8	2012	Finally, Rta-induced p21 expression diminished the activity of CDK2/cyclin E complex, and, Rta-induced 14-3-3sigma expression sequestered CDK1 and CDK2 in the cytoplasm.	3-3sigma	106-114	cyclin dependent kinase 1	Homo sapiens	138-142
22355465-7	2012	RESULTS: OVCA patient samples that demonstrated complete responses to primary platinum-based therapy demonstrated 4-fold higher CDK1 (p&lt;0.0001) and 2-fold lower PP2C (p=0.14) protein levels than samples that demonstrated incomplete responses.	Platinum	78-86	cyclin dependent kinase 1	Homo sapiens	128-132
22084170-7	2012	In MK1775-treated cells, CDC2 activity was enhanced, as determined by decreased inhibitory phosphorylation of tyrosine-15 residue and increased expression of phosphorylated histone H3, a marker of mitotic entry.	Tyrosine	110-118	cyclin dependent kinase 1	Homo sapiens	25-29
22355465-10	2012	Selective siRNA depletion of CDK1 increased sensitivity to cisplatin-induced apoptosis (p&lt;0.002).	Cisplatin	59-68	cyclin dependent kinase 1	Homo sapiens	29-33
22355465-11	2012	CONCLUSION: BAD pathway kinases and phosphatases, including CDK1 and PP2C, are associated with OVCA sensitivity to platinum and may represent therapeutic opportunities to enhance cytotoxic efficacy.	Platinum	115-123	cyclin dependent kinase 1	Homo sapiens	60-64
21904775-4	2012	We showed that Naph exhibited effective preferential             cell growth inhibition via G2/M phase arrest and apoptosis, which was associated             with reduced levels of Cdc2 and Cdc25C expression.	naphthazarin	15-19	cyclin dependent kinase 1	Homo sapiens	181-185
22482362-5	2012	Treatment with myricetin led to G2/M cell cycle arrest in T24 cells by downregulation of Cyclin B1 and cyclin-dependent kinase cdc2.	myricetin	15-24	cyclin dependent kinase 1	Homo sapiens	127-131
23185555-10	2012	In conclusion, cinnamaldehydes treatment at proapoptotic concentrations caused tubulin aggregation and dysegulation of cell cycle regulatory proteins cdk1 and cdc25C that contributed at least in part to arresting cells at G(2) phase, resulting in apoptotic cell death characterized by emergence of cleaved forms of caspase 3 and poly (ADP-ribose) polymerase (PARP).	cinnamaldehyde	15-30	cyclin dependent kinase 1	Homo sapiens	150-154
21971960-9	2012	The binding of pre-S2 LHBs with             C53 causes increased Cdk1 activation and mitotic entry, and the function of Chk1             is partially inhibited by the binding of pre-S2 LHBs with C53.	Luteinizing Hormone, beta Subunit	22-26	cyclin dependent kinase 1	Homo sapiens	65-69
21971960-11	2012	By counteracting C53, pre-S2 LHBs             promotes Cdk1 activation and mitotic entry in unperturbed cell cycle progression             and delays the function of Chk1, which may be a novel potential mechanism for             HBV-induced hepatocellular carcinoma (HCC).	Luteinizing Hormone, beta Subunit	29-33	cyclin dependent kinase 1	Homo sapiens	55-59
23251470-5	2012	The treatment of ALL leukemic cells with sulforaphane resulted in dose-dependent apoptosis and G2/M cell cycle arrest, which was associated with the activation of caspases (3, 8, and 9), inactivation of PARP, p53-independent upregulation of p21(CIP1/WAF1), and inhibition of the Cdc2/Cyclin B1 complex.	sulforaphane	41-53	cyclin dependent kinase 1	Homo sapiens	279-283
23185555-6	2012	G(2) arrest was brought about partly by cinnamaldehyde-mediated depletion of cell cycle proteins involved in regulating G(2) to M transition and spindle assembly, namely cdk1, cdc25C, mad2, cdc20 and survivin.	cinnamaldehyde	40-54	cyclin dependent kinase 1	Homo sapiens	170-174
23185265-2	2012	Roscovitine is an inhibitor of cyclin-dependent kinases that promote cell cycling (CDK1, 2), neuronal development (CDK5) and control transcription (CDK7,9).	Roscovitine	0-11	cyclin dependent kinase 1	Homo sapiens	83-87
23133576-7	2012	Concomitantly, 2OHOA led to the arrest of 1321N1 cells in the G(2)/M phase of the cell cycle, with down-regulation of cyclin B1 and Cdk1/Cdc2 proteins in the three glioma cell lines studied.	2-hydroxyoleic acid	15-20	cyclin dependent kinase 1	Homo sapiens	132-136
23133576-7	2012	Concomitantly, 2OHOA led to the arrest of 1321N1 cells in the G(2)/M phase of the cell cycle, with down-regulation of cyclin B1 and Cdk1/Cdc2 proteins in the three glioma cell lines studied.	2-hydroxyoleic acid	15-20	cyclin dependent kinase 1	Homo sapiens	137-141
22359675-8	2012	Attenuation of BITC-induced apoptosis in PUMA knockout HCT-116 cells was accompanied by enhanced G2/M phase cell cycle arrest due to induction of p21 and down regulation of cyclin-dependent kinase 1 protein.	benzyl isothiocyanate	15-19	cyclin dependent kinase 1	Homo sapiens	173-198
22623962-3	2012	We report that isocorydine induces G2/M phase arrest by increasing cyclin B1 and p-CDK1 expression levels, which was caused by decreasing the expression and inhibiting the activation of Cdc25C.	isocorydine	15-26	cyclin dependent kinase 1	Homo sapiens	83-87
22509284-6	2012	Fourth, CDK1/cyclin B enhances SUMOylation activity through phosphorylation of Ubc9 at serine 71.	Serine	87-93	cyclin dependent kinase 1	Homo sapiens	8-12
21925791-0	2011	The cdk1-cyclin B complex is involved in everolimus triggered resistance in the PC3 prostate cancer cell line.	Everolimus	41-51	cyclin dependent kinase 1	Homo sapiens	4-8
22204398-5	2011	In the presence of WIN55212-2, cdc2 protein and mRNA expression was progressively enhanced and Tyr-15-phosporylation of cdc2 was reduced in differentiating U937 cells.	Tyrosine	95-98	cyclin dependent kinase 1	Homo sapiens	120-124
22204398-9	2011	Thus, it is possible that the cannabinoid system is able to influence one of the key steps in the immune effector function, the monocytic-macrophageal differentiation by alteration of cell cycle control proteins cdc2 and p21, and is therefore representing a promising option for therapeutic intervention in exacerbated immune reactions.	Cannabinoids	30-41	cyclin dependent kinase 1	Homo sapiens	212-216
21925791-5	2011	One reason for everolimus resistance may be up-regulation of the cdk1-cyclin B complex in prostate cancer cells, leading to enhanced progression towards G2/M.	Everolimus	15-25	cyclin dependent kinase 1	Homo sapiens	65-69
21998300-4	2011	The nucleolin level decreased upon geldanamycin treatment, and Hsp90 maintained the cyclin-dependent kinase 1 (CDK1) activity to phosphorylate nucleolin at Thr-641/707.	geldanamycin	35-47	cyclin dependent kinase 1	Homo sapiens	84-109
22077320-4	2011	The downregulation of CDC2, CCNB1, TPX2, AURKA, and AURKB, the expressions of which are involved in cell cycle arrest, was attributed to Cu ions released from CuO-NPs into medium.	Copper	137-139	cyclin dependent kinase 1	Homo sapiens	22-26
21998300-4	2011	The nucleolin level decreased upon geldanamycin treatment, and Hsp90 maintained the cyclin-dependent kinase 1 (CDK1) activity to phosphorylate nucleolin at Thr-641/707.	geldanamycin	35-47	cyclin dependent kinase 1	Homo sapiens	111-115
21998300-4	2011	The nucleolin level decreased upon geldanamycin treatment, and Hsp90 maintained the cyclin-dependent kinase 1 (CDK1) activity to phosphorylate nucleolin at Thr-641/707.	Threonine	156-159	cyclin dependent kinase 1	Homo sapiens	84-109
21998300-4	2011	The nucleolin level decreased upon geldanamycin treatment, and Hsp90 maintained the cyclin-dependent kinase 1 (CDK1) activity to phosphorylate nucleolin at Thr-641/707.	Threonine	156-159	cyclin dependent kinase 1	Homo sapiens	111-115
22210039-6	2011	Moreover, when 4",7-dimethoxyflavanone treatment caused G2/M phase arrest, an increase in CDK1 together with an increase in cyclin B was observed.	4",7-dimethoxyflavanone	15-38	cyclin dependent kinase 1	Homo sapiens	90-94
21903181-6	2011	Further biochemical studies showed that TBMS1 inhibited the levels of cyclinB1, Cdc2 and Cdc25C, but enhanced Chk2 phosphorylation.	tubeimoside I	40-45	cyclin dependent kinase 1	Homo sapiens	80-84
21924579-2	2011	We have previously shown that ethanol metabolism results in cell cycle arrest at the G2/M transition, which is partially mediated by inhibitory phosphorylation of the cyclin-dependent kinase, Cdc2.	Ethanol	30-37	cyclin dependent kinase 1	Homo sapiens	192-196
21887696-4	2011	Treatment of SCC-4 cells with curcumin caused a moderate and promoted the G(2) /M phase arrest, which was accompanied with decreases in cyclin B/CDK1 and CDC25C protein levels.	Curcumin	30-38	cyclin dependent kinase 1	Homo sapiens	145-149
22036212-0	2011	Synthesis of 6-(het) ary Xylocydine analogues and evaluating their inhibitory activities of CDK1 and CDK2 in vitro.	6-(het) ary xylocydine	13-35	cyclin dependent kinase 1	Homo sapiens	92-96
22036212-1	2011	A series of purine nucleoside analogues bearing an aryl and hetaryl group in position 6 were prepared and their biological activities were assessed by in vitro CDK1/Cyclin B1 and CDK2/Cyclin A2 kinase assay.	Purine Nucleosides	12-29	cyclin dependent kinase 1	Homo sapiens	160-164
22019170-12	2011	CONCLUSIONS: Data suggest that paclitaxel induces nuclear translocation and activation of PKC-delta, which in turn causes Golgi-Cdk1 activation, leading to Golgi associated DR5 up-regulation, and caspase-8 and 3 activation.	Paclitaxel	31-41	cyclin dependent kinase 1	Homo sapiens	128-132
22019170-0	2011	Paclitaxel induces apoptosis through activation of nuclear protein kinase C-delta and subsequent activation of Golgi associated Cdk1 in human hormone refractory prostate cancer.	Paclitaxel	0-10	cyclin dependent kinase 1	Homo sapiens	128-132
21725973-0	2011	Epigallocatechin-3-gallate induces growth inhibition and apoptosis of human anaplastic thyroid carcinoma cells through suppression of EGFR/ERK pathway and cyclin B1/CDK1 complex.	epigallocatechin gallate	0-26	cyclin dependent kinase 1	Homo sapiens	165-169
21725973-13	2011	CONCLUSIONS: Taken together, EGCG inhibits cell proliferation and induces apoptosis via suppression of the EGFR/ERK pathway and cyclin B1/CDK1 complex in ATC cells.	epigallocatechin gallate	29-33	cyclin dependent kinase 1	Homo sapiens	138-142
22019170-7	2011	Data revealed that paclitaxel induced an increase of Cdk1 activity and DR5 expression on the Golgi complex that was associated with increased cleavage of caspase-8, a DR5 downstream factor, and caspase-3 into catalytically active fragments.	Paclitaxel	19-29	cyclin dependent kinase 1	Homo sapiens	53-57
21887472-7	2011	The time required to reverse             the apoptotic effects of Evo was between 16 and 20 h. We also demonstrated that             promotion of mitotic slippage by a CDK1 inhibitor enhanced apoptosis.	evodiamine	66-69	cyclin dependent kinase 1	Homo sapiens	168-172
22019170-9	2011	Golgi associated effects were inhibited by the Cdk1 inhibitor roscovitine (Sigma), suggesting a critical role for Golgi-Cdk1.	Roscovitine	62-73	cyclin dependent kinase 1	Homo sapiens	47-51
22019170-9	2011	Golgi associated effects were inhibited by the Cdk1 inhibitor roscovitine (Sigma), suggesting a critical role for Golgi-Cdk1.	Roscovitine	62-73	cyclin dependent kinase 1	Homo sapiens	120-124
22019170-11	2011	The selective PKC-delta inhibitor rottlerin (Sigma) completely inhibited the increase of Golgi-Cdk1 activity, suggesting that nuclear PKC-delta served as an upstream regulator of Golgi-Cdk1.	rottlerin	34-43	cyclin dependent kinase 1	Homo sapiens	95-99
22019170-11	2011	The selective PKC-delta inhibitor rottlerin (Sigma) completely inhibited the increase of Golgi-Cdk1 activity, suggesting that nuclear PKC-delta served as an upstream regulator of Golgi-Cdk1.	rottlerin	34-43	cyclin dependent kinase 1	Homo sapiens	185-189
21900237-10	2011	Together, these data show that CDK1-mediated phosphorylation of serine 216 in Abi1 serves as a regulatory mechanism that may contribute to coordinated actin cytoskeleton remodeling during mitosis.	Serine	64-70	cyclin dependent kinase 1	Homo sapiens	31-35
22071694-7	2011	The Cdk1 inhibitors, RO-3306 and Purvalanol A, block Bim phosphorylation in mitotically arrested cells.	RO 3306	21-28	cyclin dependent kinase 1	Homo sapiens	4-8
22071694-7	2011	The Cdk1 inhibitors, RO-3306 and Purvalanol A, block Bim phosphorylation in mitotically arrested cells.	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	33-45	cyclin dependent kinase 1	Homo sapiens	4-8
22071694-9	2011	Furthermore, active recombinant Cdk1/cyclin B1 phosphorylates BimEL and BimL in vitro and Serine 44 on BimL has been identified as a Cdk1 phosphorylation site.	Serine	90-96	cyclin dependent kinase 1	Homo sapiens	32-36
22071694-9	2011	Furthermore, active recombinant Cdk1/cyclin B1 phosphorylates BimEL and BimL in vitro and Serine 44 on BimL has been identified as a Cdk1 phosphorylation site.	Serine	90-96	cyclin dependent kinase 1	Homo sapiens	133-137
21900237-0	2011	CDK1-mediated phosphorylation of Abi1 attenuates Bcr-Abl-induced F-actin assembly and tyrosine phosphorylation of WAVE complex during mitosis.	Tyrosine	86-94	cyclin dependent kinase 1	Homo sapiens	0-4
21900495-6	2011	However, T14 phosphorylation was not directly required for T161 phosphorylation, because Myt1 knockdown did uncouple these phosphorylations when leptomycin B prevented cyclin B1-CDK1 complexes from accumulating in cytoplasm.	leptomycin B	145-157	cyclin dependent kinase 1	Homo sapiens	178-182
21900237-6	2011	We identified serine 216 of Abi1 as a target of CDK1/cyclin B kinase that is phosphorylated in cells at the onset of mitosis.	Serine	14-20	cyclin dependent kinase 1	Homo sapiens	48-52
21885916-10	2011	Importantly, we found that while both VMY and flavopiridol inhibited intracellular CDK1 catalytic activity, VMY-1-103 was unique in its ability to severely disrupt the mitotic spindle apparatus significantly delaying metaphase and disrupting mitosis.	alvocidib	46-58	cyclin dependent kinase 1	Homo sapiens	83-87
21577208-6	2011	In this system, the maturation-inducing hormone, 1-methyladenine, stimulates Akt to reinitiate meiosis through activation of cyclin B-Cdc2.	1-methyladenine	49-64	cyclin dependent kinase 1	Homo sapiens	134-138
21570766-4	2011	This synergistic effect was associated with abrogation of CDDP-induced G2/M arrest by down-regulations of phospho-Cdc2 and p21, and inhibitions of phospho-AKT, phospho-ERK and NF-kappaB.	Cisplatin	58-62	cyclin dependent kinase 1	Homo sapiens	114-118
21195118-8	2011	Mitotic phosphorylation was abolished by roscovitine, suggesting the mitotic kinase is cyclin-dependent kinase 1.	Roscovitine	41-52	cyclin dependent kinase 1	Homo sapiens	87-112
21714029-3	2011	The key intracellular mediator after hormonal stimulation by 1-methyladenine is the protein kinase Akt/PKB, which in turn directly downregulates Myt1 and upregulates Cdc25 toward the activation of cyclin B-Cdc2.	1-methyladenine	61-76	cyclin dependent kinase 1	Homo sapiens	166-170
21878640-7	2011	Not surprisingly, we found that the absence of a full DDR in mitotic cells was associated with the high cyclin-dependent kinase 1 (CDK1) activities.	ddr	54-57	cyclin dependent kinase 1	Homo sapiens	104-129
21878640-7	2011	Not surprisingly, we found that the absence of a full DDR in mitotic cells was associated with the high cyclin-dependent kinase 1 (CDK1) activities.	ddr	54-57	cyclin dependent kinase 1	Homo sapiens	131-135
21764208-7	2011	To verify if the observed changes in differentiation potency according to the number of cell divisions were related to cell cycle regulators, p3 ADSCs were treated with the selective CDK2 and CDK1/CDC2 inhibitor Purvalanol A.	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	212-224	cyclin dependent kinase 1	Homo sapiens	192-196
21764208-7	2011	To verify if the observed changes in differentiation potency according to the number of cell divisions were related to cell cycle regulators, p3 ADSCs were treated with the selective CDK2 and CDK1/CDC2 inhibitor Purvalanol A.	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	212-224	cyclin dependent kinase 1	Homo sapiens	197-201
21968300-5	2011	CDK1-shRNA plasmid was then transfected into the cultured HepG2 cell line with lipofectamine 2000.	Lipofectamine	79-97	cyclin dependent kinase 1	Homo sapiens	0-4
21798738-1	2011	A novel class of pyrazolopyrimidine-sulfonamides was discovered as selective dual inhibitors of aurora kinase A (AKA) and cyclin-dependent kinase 1 (CDK1).	pyrazolopyrimidine-sulfonamides	17-48	cyclin dependent kinase 1	Homo sapiens	122-147
21798738-1	2011	A novel class of pyrazolopyrimidine-sulfonamides was discovered as selective dual inhibitors of aurora kinase A (AKA) and cyclin-dependent kinase 1 (CDK1).	pyrazolopyrimidine-sulfonamides	17-48	cyclin dependent kinase 1	Homo sapiens	149-153
21734451-5	2011	It can trigger G 2/M arrest in wild type p53 containing cells, which was attributed to the decreased Cdc2 kinase activity resulting at least partly from a high level of inhibitory tyrosine phosphorylation on Cdc2 protein at Tyr-15.	Tyrosine	180-188	cyclin dependent kinase 1	Homo sapiens	101-105
21659531-4	2011	Here, we demonstrate that Ezh2 can be regulated by the cyclin-dependent kinase, CDK1, which phosphorylates Ezh2 at threonines 345 and 487.	Threonine	115-125	cyclin dependent kinase 1	Homo sapiens	80-84
21598039-7	2011	Conversely, proapoptotic concentrations of 4- and 6-shogaol induced irreversible G(2)/M arrest that was at least in part associated with down-regulation of cell cycle checkpoint proteins cdk1, cyclin B and cdc25C, as well as spindle assembly checkpoint proteins mad2, cdc20 and survivin.	shogaol	52-59	cyclin dependent kinase 1	Homo sapiens	187-191
21822277-3	2011	Mitotic mitochondrial fission depends on both the relocalization of the large GTPase DRP1 to the outer mitochondrial membrane and phosphorylation of Ser 616 on DRP1 by the mitotic kinase cyclin B-CDK1 (ref.	Serine	149-152	cyclin dependent kinase 1	Homo sapiens	196-200
21822277-7	2011	Furthermore, RALBP1 is associated with cyclin B-CDK1 kinase activity that leads to phosphorylation of DRP1 on Ser 616.	Serine	110-113	cyclin dependent kinase 1	Homo sapiens	48-52
21871177-6	2011	Phosphorylation of rpS3 increased in nocodazole-arrested mitotic cells; however, treatment with Cdk1 inhibitor or Cdk1 siRNA significantly attenuated this phosphorylation event.	Nocodazole	37-47	cyclin dependent kinase 1	Homo sapiens	114-118
21871177-9	2011	These results suggest that the phosphorylation of rpS3 by Cdk1 occurs at Thr221 during G2/M phase and, moreover, that this event is important for nuclear accumulation of rpS3.	cefodizime	73-79	cyclin dependent kinase 1	Homo sapiens	58-62
21734451-5	2011	It can trigger G 2/M arrest in wild type p53 containing cells, which was attributed to the decreased Cdc2 kinase activity resulting at least partly from a high level of inhibitory tyrosine phosphorylation on Cdc2 protein at Tyr-15.	Tyrosine	180-188	cyclin dependent kinase 1	Homo sapiens	208-212
21734451-5	2011	It can trigger G 2/M arrest in wild type p53 containing cells, which was attributed to the decreased Cdc2 kinase activity resulting at least partly from a high level of inhibitory tyrosine phosphorylation on Cdc2 protein at Tyr-15.	Tyrosine	224-227	cyclin dependent kinase 1	Homo sapiens	101-105
21734451-5	2011	It can trigger G 2/M arrest in wild type p53 containing cells, which was attributed to the decreased Cdc2 kinase activity resulting at least partly from a high level of inhibitory tyrosine phosphorylation on Cdc2 protein at Tyr-15.	Tyrosine	224-227	cyclin dependent kinase 1	Homo sapiens	208-212
21617861-5	2011	The results indicated that curcumin-induced G2/M phase arrest was associated with a marked decrease in the protein expression of cyclin A, cyclin B and cyclin-dependent kinase 1 (Cdk1).	Curcumin	27-35	cyclin dependent kinase 1	Homo sapiens	152-177
20195699-4	2011	In appropriate conditions, CDDP induced arrest at the G2/M phase accompanied by the enhanced inhibitory phosphorylation of Cdk1 and the elevated protein expression of cyclin B1.	Cisplatin	27-31	cyclin dependent kinase 1	Homo sapiens	123-127
21628402-4	2011	Consequently, several lymphoma-related ERK substrates were down-regulated by AZD6244 including MCT-1, c-Myc, Bcl-2, Mcl-1, and CDK1/2.	AZD 6244	77-84	cyclin dependent kinase 1	Homo sapiens	127-131
21592546-5	2011	RESULTS: Cisplatin consistently induced transient S-phase arrest by inhibiting Cdk2/cyclin A complex in S-phase at 12 h and then a durable G2/M-arrest by inhibiting Cdc2/cyclin B complex at 12-18 h. These inhibitions were associated with Chk1 and Chk2 activation and resultant increase in inhibitory tyrosine phosphorylation of Cdk2 and Cdc2.	Cisplatin	9-18	cyclin dependent kinase 1	Homo sapiens	165-169
21592546-5	2011	RESULTS: Cisplatin consistently induced transient S-phase arrest by inhibiting Cdk2/cyclin A complex in S-phase at 12 h and then a durable G2/M-arrest by inhibiting Cdc2/cyclin B complex at 12-18 h. These inhibitions were associated with Chk1 and Chk2 activation and resultant increase in inhibitory tyrosine phosphorylation of Cdk2 and Cdc2.	Cisplatin	9-18	cyclin dependent kinase 1	Homo sapiens	337-341
21550420-6	2011	We show that one of these sites, T1426 (adjacent to the C-terminal LXXLL nuclear receptor interaction motif), is an in vivo target of Cdks in mammalian cells and an in vitro target of Cdk1 and Cdk2.	1,4,7,10-Tetraazacyclododecane tetrahydrochloride	33-38	cyclin dependent kinase 1	Homo sapiens	134-138
21550420-6	2011	We show that one of these sites, T1426 (adjacent to the C-terminal LXXLL nuclear receptor interaction motif), is an in vivo target of Cdks in mammalian cells and an in vitro target of Cdk1 and Cdk2.	1,4,7,10-Tetraazacyclododecane tetrahydrochloride	33-38	cyclin dependent kinase 1	Homo sapiens	184-188
21617861-5	2011	The results indicated that curcumin-induced G2/M phase arrest was associated with a marked decrease in the protein expression of cyclin A, cyclin B and cyclin-dependent kinase 1 (Cdk1).	Curcumin	27-35	cyclin dependent kinase 1	Homo sapiens	179-183
21267808-4	2011	QMP led to cell cycle arrest at the G (2)/M phase by downregulating the expression of cdk1 and cyclin B.	Q nucleotide	0-3	cyclin dependent kinase 1	Homo sapiens	86-90
21684737-0	2011	Discovery of a novel class of 2-aminopyrimidines as CDK1 and CDK2 inhibitors.	2-aminopyrimidine	30-48	cyclin dependent kinase 1	Homo sapiens	52-56
21684737-2	2011	Substitution with pyrrolidine-3,4-diol at the 4-position of phenol provided potent inhibitory activity against CDK1 and CDK2.	Pyrrolidine-3,4-diol	18-38	cyclin dependent kinase 1	Homo sapiens	111-115
21684737-2	2011	Substitution with pyrrolidine-3,4-diol at the 4-position of phenol provided potent inhibitory activity against CDK1 and CDK2.	Phenol	60-66	cyclin dependent kinase 1	Homo sapiens	111-115
21324423-9	2011	In order to implicate HAT activity, we treated cells with the HAT inhibitor anacardic acid and determined that HAT inhibition results in loss of expression of cdc2 mRNA.	anacardic acid	76-90	cyclin dependent kinase 1	Homo sapiens	159-163
21267808-7	2011	GW9662, a PPAR- gamma antagonist, significantly suppressed the effects of 10 % QMP on cell proliferation and on the expression of cyclin B and cdk1.	2-chloro-5-nitrobenzanilide	0-6	cyclin dependent kinase 1	Homo sapiens	143-147
21267808-7	2011	GW9662, a PPAR- gamma antagonist, significantly suppressed the effects of 10 % QMP on cell proliferation and on the expression of cyclin B and cdk1.	Q nucleotide	79-82	cyclin dependent kinase 1	Homo sapiens	143-147
21389100-5	2011	RESULTS: MK-1775 treatment led to the inhibition of Wee1 kinase and reduced inhibitory phosphorylation of its substrate Cdc2.	adavosertib	9-16	cyclin dependent kinase 1	Homo sapiens	120-124
21712819-2	2011	Here we report that upon mitotic entry, Cdk1 specifically phosphorylates threonine 371 of TRF1, a telomere binding protein implicated in the regulation of sister telomere cohesion.	Threonine	73-82	cyclin dependent kinase 1	Homo sapiens	40-44
21624128-7	2011	Costunolide up-regulated the expression of phosphorylated Chk2 (Thr 68), phosphorylated Cdc25c (Ser 216), phosphorylated Cdk1 (Tyr 15) and cyclin B1 in HA22T/VGH cells.	costunolide	0-11	cyclin dependent kinase 1	Homo sapiens	121-125
21376032-4	2011	At concentrations of 2-3 muM, icaritin induced cell cycle arrest at the G(2)/M phase accompanied by a down-regulation of the expression levels of the G(2)/M regulatory proteins such as cyclinB, cdc2 and cdc25C.	icaritin	30-38	cyclin dependent kinase 1	Homo sapiens	194-198
21255143-7	2011	RESULTS: Our data demonstrate that human eosinophils express five known targets for R-roscovitine: CDK1, -2, -5, -7 and -9.	Roscovitine	84-97	cyclin dependent kinase 1	Homo sapiens	99-103
21565170-5	2011	Further evidence of phosphorylation of endogenous DNMT1 at position 154 by CDKs is also found in 293 cells treated with roscovitine, a specific inhibitor of CDK1, 2 and 5.	Roscovitine	120-131	cyclin dependent kinase 1	Homo sapiens	157-170
21539811-6	2011	DOX-induced G2/M cell cycle arrest and the reduction in cyclin B and cdc2 levels after DOX treatment were significantly reduced by Nek6 overexpression.	Doxorubicin	0-3	cyclin dependent kinase 1	Homo sapiens	69-73
21539811-6	2011	DOX-induced G2/M cell cycle arrest and the reduction in cyclin B and cdc2 levels after DOX treatment were significantly reduced by Nek6 overexpression.	Doxorubicin	87-90	cyclin dependent kinase 1	Homo sapiens	69-73
21569376-4	2011	We found that the characteristic dephosphorylation of an inhibitory phosphate on Cdk1 did not occur in infected cells expressing Vif.	Phosphates	68-77	cyclin dependent kinase 1	Homo sapiens	81-85
21516136-11	2011	The expression of cyclins A/B and cyclin-dependent kinase 1 was reversibly regulated by EGCG (200 mumol/L).	epigallocatechin gallate	88-92	cyclin dependent kinase 1	Homo sapiens	34-59
21395545-7	2011	The kinases modulated by sulfur and selenium derivatives include MAP, ERK, JNK, Akt, Cdc2, Cyclin B1 and Cdc25c amongst others.	Sulfur	25-31	cyclin dependent kinase 1	Homo sapiens	85-89
21395545-7	2011	The kinases modulated by sulfur and selenium derivatives include MAP, ERK, JNK, Akt, Cdc2, Cyclin B1 and Cdc25c amongst others.	Selenium	36-44	cyclin dependent kinase 1	Homo sapiens	85-89
21504622-9	2011	RESULTS: Isochaihulactone caused cell cycle arrest at G2/M phase in LNCaP cells, which was correlated with an increase of p53 and p21 levels and downregulation of the checkpoint proteins cdc25c, cyclin B1, and cdc2.	isochaihulactone	9-25	cyclin dependent kinase 1	Homo sapiens	187-191
21331449-8	2011	Similarly, in MG63 cells, GA mediated G2/M cell cycle arrest, which was associated with a decrease in phospho-cdc2 (Thr 161) and cdc25B.	gambogic acid	26-28	cyclin dependent kinase 1	Homo sapiens	110-114
21331449-8	2011	Similarly, in MG63 cells, GA mediated G2/M cell cycle arrest, which was associated with a decrease in phospho-cdc2 (Thr 161) and cdc25B.	Threonine	116-119	cyclin dependent kinase 1	Homo sapiens	110-114
21498573-4	2011	We identified Thr 1415 of the CAP-D3 subunit as a Cdk1 phosphorylation site, which proved crucial as it was required for the Polo kinase Plk1 (Polo-like kinase 1) to localize to chromosome axes through binding to CAP-D3 and thereby hyperphosphorylate the condensin II complex.	Threonine	14-17	cyclin dependent kinase 1	Homo sapiens	50-54
21344160-0	2011	The novel synthesized 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one (Smh-3) compound induces G2/M phase arrest and mitochondrial-dependent apoptotic cell death through inhibition of CDK1 and AKT activity in HL-60 human leukemia cells.	2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one	22-81	cyclin dependent kinase 1	Homo sapiens	196-200
21344160-0	2011	The novel synthesized 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one (Smh-3) compound induces G2/M phase arrest and mitochondrial-dependent apoptotic cell death through inhibition of CDK1 and AKT activity in HL-60 human leukemia cells.	smh-3	83-88	cyclin dependent kinase 1	Homo sapiens	196-200
21344160-5	2011	Within 0, 12, 24 and 48 h of treatment, Smh-3 inhibited CDK1 activity and decreased protein levels of CDK1, cyclin A and cyclin B.	smh-3	40-45	cyclin dependent kinase 1	Homo sapiens	56-60
21344160-5	2011	Within 0, 12, 24 and 48 h of treatment, Smh-3 inhibited CDK1 activity and decreased protein levels of CDK1, cyclin A and cyclin B.	smh-3	40-45	cyclin dependent kinase 1	Homo sapiens	102-106
21367897-8	2011	Finally, BaP treatment activated p90RSK and its downstream target CDK1.	Benzo(a)pyrene	9-12	cyclin dependent kinase 1	Homo sapiens	66-70
21321122-9	2011	The elevated cdc2 had inactivating phosphorylation on Thr(14) or Tyr(15), and possibly both, due to an increase in the responsible Wee1 and Myt1 kinases.	Threonine	54-57	cyclin dependent kinase 1	Homo sapiens	13-17
21321122-9	2011	The elevated cdc2 had inactivating phosphorylation on Thr(14) or Tyr(15), and possibly both, due to an increase in the responsible Wee1 and Myt1 kinases.	Tyrosine	65-68	cyclin dependent kinase 1	Homo sapiens	13-17
21321122-10	2011	In cells that harbored cytoplasmic cyclin B1 or cdc2, there was also an accumulation of the phosphatase-inactive cdc25C phosphorylated on Ser(216), unable to activate cdc2.	Serine	138-141	cyclin dependent kinase 1	Homo sapiens	113-117
21504622-14	2011	CONCLUSIONS: Isochaihulactone apparently induces G2/M cell cycle arrest via downregulation of cyclin B1 and cdc2, and induces cellular death by upregulation of NAG-1 via JNK activation in LNCaP cells.	isochaihulactone	13-29	cyclin dependent kinase 1	Homo sapiens	108-112
21209116-5	2011	This screening identified roscovitine, a selective inhibitor of cyclin-dependent kinase 1 (CDK1), CDK2, CDK5, and CDK7.	Roscovitine	26-37	cyclin dependent kinase 1	Homo sapiens	64-89
21447176-8	2011	Western blotting demonstrated that Osthole down-regulated the expressions of Cyclin B1, p-Cdc2 and Bcl-2 and up-regulated the expressions of Bax in A549 cells.	osthol	35-42	cyclin dependent kinase 1	Homo sapiens	90-94
21258042-0	2011	6,7,4"-trihydroxyisoflavone inhibits HCT-116 human colon cancer cell proliferation by targeting CDK1 and CDK2.	6,7,4'-trihydroxyisoflavone	0-27	cyclin dependent kinase 1	Homo sapiens	96-100
21108658-7	2011	Western blot and real-time PCR analyses further confirmed that melatonin"s inhibitory effect was possibly because of downregulation of cyclin D1 and CDK4, related to the G(1) phase, and of cyclin B1 and CDK1, related to the G(2) /M phase.	Melatonin	63-72	cyclin dependent kinase 1	Homo sapiens	203-207
21108658-10	2011	These findings provide evidence that melatonin may significantly delay osteoblast proliferation in a time-dependent manner and this inhibition involves the downregulation of cyclin D1 and CDK4, related to the G(1) phase, and of cyclin B1 and CDK1, related to the G(2) /M phase.	Melatonin	37-46	cyclin dependent kinase 1	Homo sapiens	242-246
21209116-5	2011	This screening identified roscovitine, a selective inhibitor of cyclin-dependent kinase 1 (CDK1), CDK2, CDK5, and CDK7.	Roscovitine	26-37	cyclin dependent kinase 1	Homo sapiens	91-95
21468563-0	2011	Myricetin induces G2/M phase arrest in HepG2 cells by inhibiting the activity of the cyclin B/Cdc2 complex.	myricetin	0-9	cyclin dependent kinase 1	Homo sapiens	94-98
21468563-5	2011	Western blot analysis showed that myricetin increased the protein levels of the p53/p21 cascade, and markedly decreased Cdc2 and cyclin B1 protein levels in HepG2 cells.	myricetin	34-43	cyclin dependent kinase 1	Homo sapiens	120-124
21468563-6	2011	Additionally, myricetin treatment resulted in the up-regulation of Thr14/Tyr15 phosphorylated (inactive) Cdc2 and p27, and the down-regulation of CDK7 kinase protein, as well as CDK7-mediated Thr161 phosphorylated (active) Cdc2.	myricetin	14-23	cyclin dependent kinase 1	Homo sapiens	105-109
21468563-6	2011	Additionally, myricetin treatment resulted in the up-regulation of Thr14/Tyr15 phosphorylated (inactive) Cdc2 and p27, and the down-regulation of CDK7 kinase protein, as well as CDK7-mediated Thr161 phosphorylated (active) Cdc2.	myricetin	14-23	cyclin dependent kinase 1	Homo sapiens	223-227
21468563-7	2011	These data indicate that a decrease in cyclin B/Cdc2 complex activity mediated G2/M phase arrest induced by myricetin in HepG2 cells.	myricetin	108-117	cyclin dependent kinase 1	Homo sapiens	48-52
21278485-3	2011	Recently, we and others demonstrate that CDK1 and CDK2 phosphorylate EZH2 at threonine 350 (T350) and that T350 phosphorylation is important for the binding of EZH2 to PRC2 recruiters, such as noncoding RNAs (ncRNAs) HOTAIR and XIST, and for the effective recruitment of PRC2 to EZH2 target loci in cells.	Threonine	77-86	cyclin dependent kinase 1	Homo sapiens	41-45
20979106-9	2011	Restored GPR43 expression, coupled with propionate treatment, induced an upregulation of p21 and a decrease in the levels of cyclin D3 and cyclin-dependent kinases (CDKs) 1 and 2, while the CDK4 and CDK6 levels remained unchanged.	Propionates	40-50	cyclin dependent kinase 1	Homo sapiens	139-178
21059642-6	2011	The ability of RUNX1 phosphorylation and not only serine to aspartic acid conversion to reduce HDAC1 binding was demonstrated using wild-type GST-RUNX1 phosphorylated in vitro using cdk1/cyclinB and by exposure of 293T cells transduced with RUNX1 and HDAC1 to roscovitine, a cdk inhibitor.	Roscovitine	260-271	cyclin dependent kinase 1	Homo sapiens	182-186
20419498-3	2011	An extensive dynamic simulation was also performed on a Flavopiridol-CDK1 complex for probing the binding pattern of Flavopiridol in the active site of CDK1.	alvocidib	56-68	cyclin dependent kinase 1	Homo sapiens	69-73
20419498-3	2011	An extensive dynamic simulation was also performed on a Flavopiridol-CDK1 complex for probing the binding pattern of Flavopiridol in the active site of CDK1.	alvocidib	56-68	cyclin dependent kinase 1	Homo sapiens	152-156
20419498-3	2011	An extensive dynamic simulation was also performed on a Flavopiridol-CDK1 complex for probing the binding pattern of Flavopiridol in the active site of CDK1.	alvocidib	117-129	cyclin dependent kinase 1	Homo sapiens	69-73
20419498-3	2011	An extensive dynamic simulation was also performed on a Flavopiridol-CDK1 complex for probing the binding pattern of Flavopiridol in the active site of CDK1.	alvocidib	117-129	cyclin dependent kinase 1	Homo sapiens	152-156
21148814-3	2011	The dual Src/Abl inhibitors BMS354825 and SKI-606 blocked Chk1-inhibitor-induced extracellular signal-regulated kinase 1/2 (ERK1/2) activation, markedly increasing apoptosis in association with BimEL up-regulation, p34(cdc2) activation, and DNA damage in MM cell lines and primary CD138(+) MM samples.	Dasatinib	28-37	cyclin dependent kinase 1	Homo sapiens	219-223
21238919-2	2011	Recent insights suggest that the cyclin-dependent kinase CDK1 phosphorylates EZH2 at specific threonine residues by sensing developmental cues to mediate self-renewal or differentiation during G2/M phase.	Threonine	94-103	cyclin dependent kinase 1	Homo sapiens	57-61
21078383-5	2011	Furthermore, HNE and, to a greater extent, the combined treatment induced dephosphorylation of Cdc2 leading to progression into mitosis as confirmed by alpha-tubulin/DAPI staining and phospho-histone H3 (Ser10) analysis.	DAPI	166-170	cyclin dependent kinase 1	Homo sapiens	95-99
21059642-2	2011	Phosphorylation of Ser-48, Ser-303, and Ser-424 by cyclin-dependent kinases (cdks) increases RUNX1 trans-activation activity without perturbing p300 interaction.	Serine	19-22	cyclin dependent kinase 1	Homo sapiens	77-81
21059642-2	2011	Phosphorylation of Ser-48, Ser-303, and Ser-424 by cyclin-dependent kinases (cdks) increases RUNX1 trans-activation activity without perturbing p300 interaction.	Serine	27-30	cyclin dependent kinase 1	Homo sapiens	77-81
21059642-2	2011	Phosphorylation of Ser-48, Ser-303, and Ser-424 by cyclin-dependent kinases (cdks) increases RUNX1 trans-activation activity without perturbing p300 interaction.	Serine	27-30	cyclin dependent kinase 1	Homo sapiens	77-81
22471459-6	2011	The results demonstrated that jaceosidin-induced G2/M phase arrest in U87 cells is associated with DNA fragmentation, up-regulation of p53 and p21 and subsequent down-regulation of cyclin B1 and CDK1 expression at mRNA as well as at protein level.	jaceosidin	30-40	cyclin dependent kinase 1	Homo sapiens	195-199
21063390-4	2011	CAMP localizes to chromosomes and the spindle including kinetochores, and undergoes CDK1-dependent phosphorylation at multiple sites during mitosis.	Cyclic AMP	0-4	cyclin dependent kinase 1	Homo sapiens	84-88
22471490-11	2011	At the same time, data revealed that cyclin A, cyclin B1, and cdc2 expression was down-regulated after sevoflurane treatment.	Sevoflurane	103-114	cyclin dependent kinase 1	Homo sapiens	62-66
20840867-4	2011	While HU potently induced CDC2 Y15 (tyrosine 15) phosphorylation, an event causing CDC2 inactivation, inhibition of ERK kinases using U0126 (a MEK inhibitor), MEK1K97M (a dominant negative MEK1), and knockdown of either ERK1 or ERK2 significantly attenuated HU-induced CDC2 Y15 phosphorylation.	Tyrosine	36-44	cyclin dependent kinase 1	Homo sapiens	26-30
20840867-4	2011	While HU potently induced CDC2 Y15 (tyrosine 15) phosphorylation, an event causing CDC2 inactivation, inhibition of ERK kinases using U0126 (a MEK inhibitor), MEK1K97M (a dominant negative MEK1), and knockdown of either ERK1 or ERK2 significantly attenuated HU-induced CDC2 Y15 phosphorylation.	Hydroxyurea	6-8	cyclin dependent kinase 1	Homo sapiens	26-30
20736132-14	2011	CONCLUSION(S): Vitamin D inhibits growth of HuLM cells through the down-regulation of PCNA, CDK1, and BCL-2 and suppresses COMT expression and activity in HuLM cells.	Vitamin D	15-24	cyclin dependent kinase 1	Homo sapiens	92-96
20736132-11	2011	Vitamin D inhibited extracellular signal-regulated kinase activation and down-regulated the expression of BCL-2, BCL-w, CDK1, and PCNA.	Vitamin D	0-9	cyclin dependent kinase 1	Homo sapiens	120-124
21918689-0	2011	Role of cyclin B1/Cdc2 up-regulation in the development of mitotic prometaphase arrest in human breast cancer cells treated with nocodazole.	Nocodazole	129-139	cyclin dependent kinase 1	Homo sapiens	18-22
21931487-7	2011	Moreover, the copolymer of 2ME with MNPs- Fe(3)O(4) blocked a nearly two-fold increase in SKM-1 cells located in G(2)/M phase than in 2ME alone, which may be associated with an accompanying increase of p21 as well as a decrease in cyclin B1 and cdc2 expression, but there was no obvious difference between the MNPs-Fe(3)O(4) and control group.	copolymer	14-23	cyclin dependent kinase 1	Homo sapiens	245-249
21931487-7	2011	Moreover, the copolymer of 2ME with MNPs- Fe(3)O(4) blocked a nearly two-fold increase in SKM-1 cells located in G(2)/M phase than in 2ME alone, which may be associated with an accompanying increase of p21 as well as a decrease in cyclin B1 and cdc2 expression, but there was no obvious difference between the MNPs-Fe(3)O(4) and control group.	fe(3)o	42-48	cyclin dependent kinase 1	Homo sapiens	245-249
21107289-2	2011	Terameprocol down-regulates the Sp1-mediated transcription of survivin and Cdk1, which is important for cell cycle progression and many other proteins.	terameprocol	0-12	cyclin dependent kinase 1	Homo sapiens	75-79
22163180-4	2011	Analysis of cell cycle regulatory proteins showed that PTX-2 increases phosphorylation of Cdc25c and decreases protein levels of Cdc2 and cyclin B1.	pectenotoxin 2	55-60	cyclin dependent kinase 1	Homo sapiens	90-94
21131960-3	2011	Here, we demonstrate that EZH2 can be phosphorylated at Thr 487 through activation of cyclin-dependent kinase 1 (CDK1).	Threonine	56-59	cyclin dependent kinase 1	Homo sapiens	86-111
21131960-3	2011	Here, we demonstrate that EZH2 can be phosphorylated at Thr 487 through activation of cyclin-dependent kinase 1 (CDK1).	Threonine	56-59	cyclin dependent kinase 1	Homo sapiens	113-117
21131960-5	2011	In human mesenchymal stem cells, activation of CDK1 promoted mesenchymal stem cell differentiation into osteoblasts through phosphorylation of EZH2 at Thr 487.	Threonine	151-154	cyclin dependent kinase 1	Homo sapiens	47-51
21857083-8	2011	In addition, curcumin significantly decreased p38MAPK and phospho-CDC-2 protein expression and increased phospho-p38MAPK, p42/44MAPK, and phospho-p42/44MAPK protein expression.	Curcumin	13-21	cyclin dependent kinase 1	Homo sapiens	66-71
21918689-2	2011	Here we report our finding that treatment of MCF-7 human breast cancer cells with nocodazole, a prototypic microtubule inhibitor, results in strong up-regulation of cyclin B1 and Cdc2 levels, and their increases are required for the development of mitotic prometaphase arrest and characteristic phenotypes.	Nocodazole	82-92	cyclin dependent kinase 1	Homo sapiens	179-183
21918689-4	2011	This early up-regulation of cyclin B1 and Cdc2 closely matched in timing the nocodazole-induced mitotic prometaphase arrest.	Nocodazole	77-87	cyclin dependent kinase 1	Homo sapiens	42-46
21918689-5	2011	Selective knockdown of cyclin B1or Cdc2 each abrogated nocodazole-induced accumulation of prometaphase cells.	Nocodazole	55-65	cyclin dependent kinase 1	Homo sapiens	35-39
21918689-6	2011	The nocodazole-induced prometaphase arrest was also abrogated by pre-treatment of cells with roscovitine, an inhibitor of cyclin-dependent kinases, or with cycloheximide, a protein synthesis inhibitor that was found to suppress cyclin B1 and Cdc2 up-regulation.	Nocodazole	4-14	cyclin dependent kinase 1	Homo sapiens	242-246
21918689-6	2011	The nocodazole-induced prometaphase arrest was also abrogated by pre-treatment of cells with roscovitine, an inhibitor of cyclin-dependent kinases, or with cycloheximide, a protein synthesis inhibitor that was found to suppress cyclin B1 and Cdc2 up-regulation.	Roscovitine	93-104	cyclin dependent kinase 1	Homo sapiens	242-246
21275261-7	2011	Analysis of the cell cycle and apoptosis regulators revealed that C-1305 strongly elevated phosphorylation of CDK1 at the inhibitory sites (Thr14/Tyr15) in HL-60 cells.	C 1305	66-72	cyclin dependent kinase 1	Homo sapiens	110-114
21660227-5	2011	Elevated labeling for inhibited phospho-CDC2 (pTyr15CDC) correlates with elevated levels of phosphorylated glycogen synthase kinase 3beta (GSK3beta).	ptyr15cdc	46-55	cyclin dependent kinase 1	Homo sapiens	40-44
21695150-10	2011	Interestingly, this arrest was dependent on the induction of autophagy, since inhibition of Rsv-induced autophagy abolishes cell cycle arrest and returns the phosphorylation of Cdc2(Y15) and Rb(S807/811), and levels of cyclin A, and B to control levels.	Resveratrol	92-95	cyclin dependent kinase 1	Homo sapiens	177-181
21918689-6	2011	The nocodazole-induced prometaphase arrest was also abrogated by pre-treatment of cells with roscovitine, an inhibitor of cyclin-dependent kinases, or with cycloheximide, a protein synthesis inhibitor that was found to suppress cyclin B1 and Cdc2 up-regulation.	Cycloheximide	156-169	cyclin dependent kinase 1	Homo sapiens	242-246
21918689-7	2011	In addition, we found that MAD2 knockdown abrogated nocodazole-induced accumulation of cyclin B1 and Cdc2 proteins, which was accompanied by an attenuation of nocodazole-induced prometaphase arrest.	Nocodazole	52-62	cyclin dependent kinase 1	Homo sapiens	101-105
21695177-8	2011	The THA-induced cell cycle arrest was accompanied by a downregulation of Cdc2.	tha	4-7	cyclin dependent kinase 1	Homo sapiens	73-77
21104938-3	2010	FNQ-induced G(2)/M arrest was correlated with a marked decrease in the expression levels of cyclin A and cyclin B, and their activating partner cyclin-dependent kinases (Cdk) 1 and 2 with concomitant induction of p53, p21, and p27.	furano-1,2-naphthoquinone	0-3	cyclin dependent kinase 1	Homo sapiens	144-182
21080703-3	2010	Here, we report the identification of a pyrazolo[1,5-a]pyrimidine derived compound, 4k (BS-194), as a selective and potent CDK inhibitor, which inhibits CDK2, CDK1, CDK5, CDK7, and CDK9 (IC50= 3, 30, 30, 250, and 90 nmol/L, respectively).	pyrazolo(1,5-a)pyrimidine	40-65	cyclin dependent kinase 1	Homo sapiens	159-163
21104938-6	2010	The combined treatment of FNQ with AG1478 (a specific EGFR inhibitor) significantly enhanced the G(2)/M arrest and apoptosis, and also led to up-regulation in Bax, p53, p21, p27, release of mitochondrial cytochrome c, and down-regulation of Bcl-2, XIAP, survivin, cyclin A, cyclin B, Cdk1, and Cdk2 in A549 cells.	furano-1,2-naphthoquinone	26-29	cyclin dependent kinase 1	Homo sapiens	284-288
21104938-6	2010	The combined treatment of FNQ with AG1478 (a specific EGFR inhibitor) significantly enhanced the G(2)/M arrest and apoptosis, and also led to up-regulation in Bax, p53, p21, p27, release of mitochondrial cytochrome c, and down-regulation of Bcl-2, XIAP, survivin, cyclin A, cyclin B, Cdk1, and Cdk2 in A549 cells.	RTKI cpd	35-41	cyclin dependent kinase 1	Homo sapiens	284-288
20564478-5	2010	GA-treated cells resulted in significant growth inhibition in a dose-dependent manner accompanied by a decrease in cyclin-dependent kinases (Cdk1), Cyclin B1, and Cdc25C, but significant increases in p-cdc2 (Tyr-15) and Cip1/p21 by western blotting.	Gallic Acid	0-2	cyclin dependent kinase 1	Homo sapiens	141-145
20309622-6	2010	Salidroside could cause G1-phase or G2-phase arrest in different cancer cell lines, meanwhile, salidroside resulted in a decrease of CDK4, cyclin D1, cyclin B1 and Cdc2, and upregulated the levels of p27(Kip1) and p21(Cip1).	rhodioloside	95-106	cyclin dependent kinase 1	Homo sapiens	164-168
20309622-7	2010	Taken together, salidroside could inhibit the growth of cancer cells by modulating CDK4-cyclin D1 pathway for G1-phase arrest and/or modulating the Cdc2-cyclin B1 pathway for G2-phase arrest.	rhodioloside	16-27	cyclin dependent kinase 1	Homo sapiens	148-152
21123648-5	2010	Ezh2 is phosphorylated by cyclin-dependent kinase 1 (CDK1) at threonine residues 345 and 487 in a cell cycle-dependent manner.	Threonine	62-71	cyclin dependent kinase 1	Homo sapiens	26-51
21123648-5	2010	Ezh2 is phosphorylated by cyclin-dependent kinase 1 (CDK1) at threonine residues 345 and 487 in a cell cycle-dependent manner.	Threonine	62-71	cyclin dependent kinase 1	Homo sapiens	53-57
20812379-5	2010	RMDE-mediated G2/M phase arrest was associated with the down-regulation of NF-kappaB, resulting in the inhibition of cyclin B1 and CDK1 expression; this may be the mechanism by which RMDE inhibits cancer cells.	rmde	0-4	cyclin dependent kinase 1	Homo sapiens	131-135
20812379-5	2010	RMDE-mediated G2/M phase arrest was associated with the down-regulation of NF-kappaB, resulting in the inhibition of cyclin B1 and CDK1 expression; this may be the mechanism by which RMDE inhibits cancer cells.	rmde	183-187	cyclin dependent kinase 1	Homo sapiens	131-135
21042745-11	2010	Furthermore, sequential treatment with the CDK1-inhibitor, flavopiridol, synergistically enhanced PBOX-induced apoptosis.	alvocidib	59-71	cyclin dependent kinase 1	Homo sapiens	43-47
20937773-0	2010	Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity.	ammonium ferrous sulfate	24-27	cyclin dependent kinase 1	Homo sapiens	0-4
20937773-3	2010	In this study, we demonstrate that procaspase-8 is phosphorylated in mitotic cells by Cdk1/cyclin B1 on Ser-387, which is located at the N terminus of the catalytic subunit p10.	Serine	104-107	cyclin dependent kinase 1	Homo sapiens	86-90
20937773-5	2010	Furthermore, RNA interference-mediated silencing of cyclin B1 or treatment with the Cdk1 inhibitor RO-3306 enhances the Fas-mediated activation and processing of procaspase-8 in mitotic cells.	RO 3306	99-106	cyclin dependent kinase 1	Homo sapiens	84-88
20554189-0	2010	12-O-Tetradecanoyl phorbol-13-acetate (TPA)-induced growth arrest is increased by silibinin by the down-regulation of cyclin B1 and cdc2 and the up-regulation of p21 expression in MDA-MB231 human breast cancer cells.	Tetradecanoylphorbol Acetate	0-37	cyclin dependent kinase 1	Homo sapiens	132-136
20554189-0	2010	12-O-Tetradecanoyl phorbol-13-acetate (TPA)-induced growth arrest is increased by silibinin by the down-regulation of cyclin B1 and cdc2 and the up-regulation of p21 expression in MDA-MB231 human breast cancer cells.	Tetradecanoylphorbol Acetate	39-42	cyclin dependent kinase 1	Homo sapiens	132-136
20554189-0	2010	12-O-Tetradecanoyl phorbol-13-acetate (TPA)-induced growth arrest is increased by silibinin by the down-regulation of cyclin B1 and cdc2 and the up-regulation of p21 expression in MDA-MB231 human breast cancer cells.	Silybin	82-91	cyclin dependent kinase 1	Homo sapiens	132-136
20554189-4	2010	Silibinin decreased the basal level of cyclin B1 and cdc2 expression, which is involved in S phase and G2/M transition.	Silybin	0-9	cyclin dependent kinase 1	Homo sapiens	53-57
20554189-6	2010	Under the same conditions, TPA-induced down-regulation of cyclin B1 and cdc2 was decreased by silibinin.	Tetradecanoylphorbol Acetate	27-30	cyclin dependent kinase 1	Homo sapiens	72-76
20554189-6	2010	Under the same conditions, TPA-induced down-regulation of cyclin B1 and cdc2 was decreased by silibinin.	Silybin	94-103	cyclin dependent kinase 1	Homo sapiens	72-76
20801879-10	2010	Ser(321) is phosphorylated in mitosis by Cdk1.	Serine	0-3	cyclin dependent kinase 1	Homo sapiens	41-45
20926293-3	2010	HTMC treatment also led to an inhibition of cell-cycle regulatory proteins phosphorylation of cdc2 (Tyr(15) and Tyr(161)) and Rb (Ser(795) and Ser(807/811)), which was accompanied by the accumulation of tumor suppressor genes p53 and p21.	Tyrosine	100-103	cyclin dependent kinase 1	Homo sapiens	94-98
20966048-3	2010	First, we found that PR-Set7 is phosphorylated at Ser 29 (S29) specifically by the cyclin-dependent kinase 1 (cdk1)/cyclinB complex, primarily from prophase through early anaphase, subsequent to global accumulation of H4K20me1.	Serine	50-53	cyclin dependent kinase 1	Homo sapiens	83-108
20966048-3	2010	First, we found that PR-Set7 is phosphorylated at Ser 29 (S29) specifically by the cyclin-dependent kinase 1 (cdk1)/cyclinB complex, primarily from prophase through early anaphase, subsequent to global accumulation of H4K20me1.	Serine	50-53	cyclin dependent kinase 1	Homo sapiens	110-114
20878066-6	2010	Amifostine promotes entry into the G2-M phase through regulation of cyclin-dependent kinase-1 activity in cells with dysfunctional p53, thereby enhancing cancer cell sensitivity to paclitaxel.	Amifostine	0-10	cyclin dependent kinase 1	Homo sapiens	68-93
20875789-4	2010	We previously reported that p47 phosphorylation on Serine-140 by Cdc2 results in mitotic inhibition of the p97/p47 pathway [11].	Serine	51-57	cyclin dependent kinase 1	Homo sapiens	65-69
20875789-5	2010	In this study, we demonstrate that p37 is phosphorylated on Serine-56 and Threonine-59 by Cdc2 at mitosis, and this phosphorylated p37 does not bind to Golgi membranes.	Serine	60-66	cyclin dependent kinase 1	Homo sapiens	90-94
20875789-5	2010	In this study, we demonstrate that p37 is phosphorylated on Serine-56 and Threonine-59 by Cdc2 at mitosis, and this phosphorylated p37 does not bind to Golgi membranes.	Threonine	74-83	cyclin dependent kinase 1	Homo sapiens	90-94
20655883-6	2010	Furthermore, cells following knockdown of Plk1, which induced increase of Cyclin B1, p-Cdc2 and p73alpha with a decrease in p-Cdc25C, were more sensitive to CDDP.	Cisplatin	157-161	cyclin dependent kinase 1	Homo sapiens	87-91
20878089-13	2010	Curcumin induced cell cycle arrest at the G2/M phase by decreasing the Cdc2 expression.	Curcumin	0-8	cyclin dependent kinase 1	Homo sapiens	71-75
20878096-12	2010	Protein expression levels of cell cycle regulating proteins CDK1, CDK2, CDK4, cyclin D1, cyclin E, p19 and p27 were markedly altered by simvastatin.	Simvastatin	136-147	cyclin dependent kinase 1	Homo sapiens	60-64
20673999-6	2010	Catalase could prevent the BisGMA-induced alteration of cell cycle-related genes (cdc2, cdc25C, cyclinB1) and HO-1 expression in dental pulp cells.	bisgma	27-33	cyclin dependent kinase 1	Homo sapiens	82-86
20935635-3	2010	Here, we demonstrate that under physiological conditions, cyclin-dependent kinase 1 (CDK1) and cyclin-dependent kinase 2 (CDK2) phosphorylate EZH2 at Thr 350 in an evolutionarily conserved motif.	Threonine	150-153	cyclin dependent kinase 1	Homo sapiens	58-83
20829196-4	2010	I-387 induced a strong and concentration-dependent G2-M arrest in PC-3 cells by constitutive activation of Cdc2/cyclin B1 complex and destabilized polymerization of purified tubulin in vitro by binding to the colchicine-binding site.	i-387	0-5	cyclin dependent kinase 1	Homo sapiens	107-111
20935635-3	2010	Here, we demonstrate that under physiological conditions, cyclin-dependent kinase 1 (CDK1) and cyclin-dependent kinase 2 (CDK2) phosphorylate EZH2 at Thr 350 in an evolutionarily conserved motif.	Threonine	150-153	cyclin dependent kinase 1	Homo sapiens	85-89
20739936-10	2010	Thus, our study resolves the conserved mechanisms of CPC targeting to centromeres, highlighting a key role of Cdk1-cyclin B in chromosome bi-orientation.	cpc	53-56	cyclin dependent kinase 1	Homo sapiens	110-114
21034513-10	2010	For the most sensitive SMMC-7721 cells, lobaplatin arrested cell cycle progression in G1 and G2/M phases time-dependently which might be associated with the down-regulation of cyclin B, CDK1, CDC25C, phosphorylated CDK1 (pCDK1), pCDK4, Rb, E2F, and pRb, and the up-regulation of p53, p21, and p27.	lobaplatin	40-50	cyclin dependent kinase 1	Homo sapiens	186-190
21034513-10	2010	For the most sensitive SMMC-7721 cells, lobaplatin arrested cell cycle progression in G1 and G2/M phases time-dependently which might be associated with the down-regulation of cyclin B, CDK1, CDC25C, phosphorylated CDK1 (pCDK1), pCDK4, Rb, E2F, and pRb, and the up-regulation of p53, p21, and p27.	lobaplatin	40-50	cyclin dependent kinase 1	Homo sapiens	215-219
20576617-4	2010	We also show that this binding is cell cycle-regulated and dependent on the phosphorylation of LBR Ser-71 by p34(cdc2) kinase.	Serine	99-102	cyclin dependent kinase 1	Homo sapiens	113-117
20661218-6	2010	Whereas RO-3306, a selective inhibitor of cyclin-dependent kinase 1 (Cdk1), suppresses this phosphorylation at Ser315 of p53, ZM447439, targeting Aurora A/B kinases, shows no effect.	RO 3306	8-15	cyclin dependent kinase 1	Homo sapiens	42-67
20661218-6	2010	Whereas RO-3306, a selective inhibitor of cyclin-dependent kinase 1 (Cdk1), suppresses this phosphorylation at Ser315 of p53, ZM447439, targeting Aurora A/B kinases, shows no effect.	RO 3306	8-15	cyclin dependent kinase 1	Homo sapiens	69-73
21442024-10	2010	Among other changes, Shp2 inhibition increased phosphorylation of Src Tyr-530 and Cdk1 Thr-14/Tyr-15 and decreased phosphorylation of Erk1 and Erk2 activating sites in the tumors.	Threonine	87-90	cyclin dependent kinase 1	Homo sapiens	82-86
20413215-9	2010	Furthermore, we found the dephosphorylation of Cdk1 at Thr161 induced by GA was abrogated, followed by a remarkable disruption of G2/M arrest when the cells were pre-incubated with caffeine.	gambogic acid	73-75	cyclin dependent kinase 1	Homo sapiens	47-51
20413215-9	2010	Furthermore, we found the dephosphorylation of Cdk1 at Thr161 induced by GA was abrogated, followed by a remarkable disruption of G2/M arrest when the cells were pre-incubated with caffeine.	Caffeine	181-189	cyclin dependent kinase 1	Homo sapiens	47-51
20724915-8	2010	Concurrent with the late G1 arrest, we observed an overexpression of p27 along with a decreased expression of p21, cyclin-dependent kinase 1, cyclin-dependent kinase 4, and cyclin D. Clotrimazole induced the translocation of mitochondrial-bound hexokinase II to the cytoplasm and the release of cytochrome c into the cytoplasm.	Clotrimazole	183-195	cyclin dependent kinase 1	Homo sapiens	115-140
20570672-7	2010	Subthreshold 1-MA was found to cause a transient accumulation of Cdc2/cyclin B into the nucleus.	1-methyladenine	13-17	cyclin dependent kinase 1	Homo sapiens	65-69
20664969-7	2010	Immunoblot analysis demonstrated that oridonin treatment increased expression levels of p-JNK, p-p38, p-p53 and p21, elevated the level of cyclin B1/p-Cdc2 (Tyr15) complex, and inhibited the expression of p-ERK.	oridonin	38-46	cyclin dependent kinase 1	Homo sapiens	151-155
20713444-4	2010	Cyclin-dependent kinase (CDK1)-dependent phosphorylation of Srs2 did not influence checkpoint-mediated G(2) arrest or maintenance in PRR-deficient cells but was critical for HR-dependent checkpoint recovery following release from CLUV exposure.	cluv	230-234	cyclin dependent kinase 1	Homo sapiens	25-29
20736311-5	2010	Studies aimed at identifying these kinases suggested that CDK1 activity is required to sustain Erk5 phosphorylation in mitosis, as treatment with RO3306, a CDK1 inhibitor, reversed mitotic phosphorylation of Erk5.	RO 3306	146-152	cyclin dependent kinase 1	Homo sapiens	58-62
20736311-5	2010	Studies aimed at identifying these kinases suggested that CDK1 activity is required to sustain Erk5 phosphorylation in mitosis, as treatment with RO3306, a CDK1 inhibitor, reversed mitotic phosphorylation of Erk5.	RO 3306	146-152	cyclin dependent kinase 1	Homo sapiens	156-160
20443032-5	2010	At the same time, ERK and c-Jun N-terminal kinase (JNK) as well as cell division control protein 2 homolog (Cdc2) were found to be highly phosphorylated, which could be counteracted with the antioxidant N-acetylcysteine (NAC).	Acetylcysteine	203-219	cyclin dependent kinase 1	Homo sapiens	108-112
20443032-5	2010	At the same time, ERK and c-Jun N-terminal kinase (JNK) as well as cell division control protein 2 homolog (Cdc2) were found to be highly phosphorylated, which could be counteracted with the antioxidant N-acetylcysteine (NAC).	Acetylcysteine	221-224	cyclin dependent kinase 1	Homo sapiens	108-112
20944112-6	2010	In MDA-MB-231 cells, 30 muM SFN caused S and G2/M cell-cycle arrest associated with increased p21WAF1 and p27KIP1 levels and decreased cyclin A, cyclin B1 and CDC2 levels.	sulforaphane	28-31	cyclin dependent kinase 1	Homo sapiens	159-163
20682078-9	2010	Lycorine also down-regulated p21-related gene expression, including Cdc2, Cyclin B, Cdk2 and Cyclin E, promoted Bid truncation, decreased IkappaB phosphorylation and blocked NF-kappaB nuclear import.	lycorine	0-8	cyclin dependent kinase 1	Homo sapiens	68-72
20808790-7	2010	Enforced translocation of cyclin B1 and Cdk1 into mitochondria with a mitochondrial-targeting-peptide increased levels of Ser-315 phosphorylation on mitochondrial p53, improved ATP production and decreased apoptosis by sequestering p53 from binding to Bcl-2 and Bcl-xL.	Adenosine Triphosphate	177-180	cyclin dependent kinase 1	Homo sapiens	40-44
20808790-10	2010	These results demonstrate a unique anti-apoptotic function of mitochondrial p53 regulated by cyclin B1/Cdk1-mediated Ser-315 phosphorylation in p53-wild-type tumor cells, which may provide insights for improving the efficacy of anti-cancer therapy, especially for tumors that retain p53.	Serine	117-120	cyclin dependent kinase 1	Homo sapiens	103-107
20808790-5	2010	The mitochondrial kinase activity of cyclin B1/Cdk1 was found to specifically phosphorylate p53 at Ser-315 residue, leading to enhanced mitochondrial ATP production and reduced mitochondrial apoptosis.	Serine	99-102	cyclin dependent kinase 1	Homo sapiens	47-51
20808790-5	2010	The mitochondrial kinase activity of cyclin B1/Cdk1 was found to specifically phosphorylate p53 at Ser-315 residue, leading to enhanced mitochondrial ATP production and reduced mitochondrial apoptosis.	Adenosine Triphosphate	150-153	cyclin dependent kinase 1	Homo sapiens	47-51
20808790-7	2010	Enforced translocation of cyclin B1 and Cdk1 into mitochondria with a mitochondrial-targeting-peptide increased levels of Ser-315 phosphorylation on mitochondrial p53, improved ATP production and decreased apoptosis by sequestering p53 from binding to Bcl-2 and Bcl-xL.	Serine	122-125	cyclin dependent kinase 1	Homo sapiens	40-44
20352291-5	2010	Further studies indicated that XN0502 induced time- and dose-dependent G2/M arrest, accompanying with the reduction of CDC2/p34 expression and the downregulation of CDK7.	4-(4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-pyrazol-3-amine	31-37	cyclin dependent kinase 1	Homo sapiens	119-123
20596677-7	2010	These events may explain the inappropriate activation of cdc2, implicated in G2/M phase arrest and probably induced by the mitotane and IR in the combined treatment.	Mitotane	123-131	cyclin dependent kinase 1	Homo sapiens	57-61
20596677-8	2010	Indeed, treatment with purvalanol, a cdc2-inhibitor prevents cell cycle arrest, triggering the G2/M transition.	purvalanol B	23-33	cyclin dependent kinase 1	Homo sapiens	37-41
20596677-9	2010	The observation that mitotane and IR in combination treatment amplifies the activation level of cyclin B/cdc2 complexes contributing to cell cycle arrest, suggests that the MPF could function as a master signal for controlling the temporal order of different mitotic events.	Mitotane	21-29	cyclin dependent kinase 1	Homo sapiens	105-109
20682067-6	2010	alpha-Santalol altered expressions of cell cycle proteins such as cyclin A, cyclin B1, Cdc2, Cdc25c, p-Cdc25c and Cdk2.	a-santalol	0-14	cyclin dependent kinase 1	Homo sapiens	87-91
20406171-4	2010	Wee 1 is a tyrosine kinase that phosphorylates CDC2 at Tyr 15 and as such plays a pivotal role in the G2 DNA damage checkpoint.	Tyrosine	55-58	cyclin dependent kinase 1	Homo sapiens	47-51
20596601-10	2010	In the core signaling pathways of glioblastoma, curcumin either significantly influences the p53 pathway by enhancing p53 and p21 and suppressing cdc2 or significantly inhibits the RB pathway by enhancing CDKN2A/p16 and suppressing phosphorylated RB.	Curcumin	48-56	cyclin dependent kinase 1	Homo sapiens	146-150
20683025-5	2010	Growth suppression by gamma-tocotrienol was accompanied by changes in the levels of cell cycle regulatory proteins, notably, Rb/E2F complex, cyclin D1/cdk4 and cyclin B1/cdk1, as exemplified by loss of cyclin D1, inhibition of specific Rb phosphorylation (pRb-p at Thr821), and by the time- and dose-dependent increase in the expression of NQO2.	plastochromanol 8	22-39	cyclin dependent kinase 1	Homo sapiens	170-174
20463006-0	2010	MJ-29 inhibits tubulin polymerization, induces mitotic arrest, and triggers apoptosis via cyclin-dependent kinase 1-mediated Bcl-2 phosphorylation in human leukemia U937 cells.	6-pyrrolidinyl-2-(2-hydroxyphenyl)-4-quinazolinone	0-5	cyclin dependent kinase 1	Homo sapiens	90-115
20463006-4	2010	MJ-29 caused mitotic arrest by activating cyclin-dependent kinase 1 (CDK1)/cyclin B complex activity.	6-pyrrolidinyl-2-(2-hydroxyphenyl)-4-quinazolinone	0-5	cyclin dependent kinase 1	Homo sapiens	42-67
20463006-4	2010	MJ-29 caused mitotic arrest by activating cyclin-dependent kinase 1 (CDK1)/cyclin B complex activity.	6-pyrrolidinyl-2-(2-hydroxyphenyl)-4-quinazolinone	0-5	cyclin dependent kinase 1	Homo sapiens	69-73
20463006-5	2010	MJ-29-induced growth inhibition and activation of CDK1 activity were significantly attenuated by roscovitine (CDK inhibitor) and CDK1 small interfering RNA (siRNA).	6-pyrrolidinyl-2-(2-hydroxyphenyl)-4-quinazolinone	0-5	cyclin dependent kinase 1	Homo sapiens	50-54
20463006-5	2010	MJ-29-induced growth inhibition and activation of CDK1 activity were significantly attenuated by roscovitine (CDK inhibitor) and CDK1 small interfering RNA (siRNA).	6-pyrrolidinyl-2-(2-hydroxyphenyl)-4-quinazolinone	0-5	cyclin dependent kinase 1	Homo sapiens	129-133
20463006-5	2010	MJ-29-induced growth inhibition and activation of CDK1 activity were significantly attenuated by roscovitine (CDK inhibitor) and CDK1 small interfering RNA (siRNA).	Roscovitine	97-108	cyclin dependent kinase 1	Homo sapiens	50-54
20463006-6	2010	Furthermore, MJ-29-induced Bcl-2 phosphorylation was also significantly attenuated by CDK1 siRNA.	6-pyrrolidinyl-2-(2-hydroxyphenyl)-4-quinazolinone	13-18	cyclin dependent kinase 1	Homo sapiens	86-90
20463006-11	2010	In conclusion, our results suggest that MJ-29 induces mitotic arrest and apoptosis in U937 cells via CDK1-mediated Bcl-2 phosphorylation and inhibits the in vivo tumor growth of U937 xenograft mice.	6-pyrrolidinyl-2-(2-hydroxyphenyl)-4-quinazolinone	40-45	cyclin dependent kinase 1	Homo sapiens	101-105
20439461-5	2010	We further identify that the mitotic phosphorylation and subcellular localization of MLL5 are dependent on Cdc2 kinase activity, and Thr-912 is the Cdc2-targeting site.	Threonine	133-136	cyclin dependent kinase 1	Homo sapiens	148-152
20668692-2	2010	Human cdc25C is phosphorylated on Proline-dependent SP and TP sites when it becomes active at mitosis and the prevalent model is that this phosphorylation/activation of cdc25C would be part of an amplification loop with cdk1/cyclin B1.	Proline	34-41	cyclin dependent kinase 1	Homo sapiens	220-224
20371239-7	2010	Western blot analysis indicated that BTZQ may up-regulate expression of cyclin B, p21, p53 and cytochrome c, but down-regulate cdk1 expression in a dose-dependent manner, leading to apoptosis of BC-M1 cells.	btzq	37-41	cyclin dependent kinase 1	Homo sapiens	127-131
20206141-3	2010	Recent data demonstrating enhanced MTA-induced tumour cell apoptosis upon combination with the cyclin dependent kinase (CDK)-1 inhibitor flavopiridol prompted us to examine whether this compound could similarly enhance the effect of the PBOX compounds.	alvocidib	137-149	cyclin dependent kinase 1	Homo sapiens	95-126
20206141-6	2010	The addition of flavopiridol following PBOX-6 treatment did however result in an accelerated exit from the G2/M transition accompanied by an enhanced downregulation and deactivation of the CDK1/cyclin B1 complex and an enhanced degradation of the inhibitor of apoptosis protein (IAP) survivin.	alvocidib	16-28	cyclin dependent kinase 1	Homo sapiens	189-193
20368335-1	2010	Cdc25A is a dual specificity protein phosphatase that activates cyclin/cyclin-dependent protein kinase (Cdk) complexes by removing inhibitory phosphates from conserved threonine and tyrosine in Cdks.	Phosphates	142-152	cyclin dependent kinase 1	Homo sapiens	104-107
20627562-1	2010	MCS-5A, an analog of sangivamycin, selectively inhibits the cyclin-dependent kinases CDK1 and 4 in HL-60 cells in vitro (IC(50): 9.6 and 8.8 1V, respectively), while weakly inhibiting other housekeeping protein kinases.	4-amino-6-bromo-7-(xylofuranosyl)pyrrolo(2,3-d)pyrimidine-5-carboxamide	0-6	cyclin dependent kinase 1	Homo sapiens	85-95
20627562-1	2010	MCS-5A, an analog of sangivamycin, selectively inhibits the cyclin-dependent kinases CDK1 and 4 in HL-60 cells in vitro (IC(50): 9.6 and 8.8 1V, respectively), while weakly inhibiting other housekeeping protein kinases.	sangivamycin	21-33	cyclin dependent kinase 1	Homo sapiens	85-95
20627562-2	2010	MCS-5A effectively induces HL-60 cell cycle arrest at the G(1) and G(2)/M phases through direct inhibition of CDK1 and 4 activity.	4-amino-6-bromo-7-(xylofuranosyl)pyrrolo(2,3-d)pyrimidine-5-carboxamide	0-6	cyclin dependent kinase 1	Homo sapiens	110-120
20446899-2	2010	This study suggested that G2/M cell cycle arrest was triggered by ROS/NO productions with regulations of p53, p21, cell division cycle 25C (Cdc25C), Cdc2 and cyclin B1, which were able to be prevented by protein tyrosine kinase (PTK) activity inhibitor genistein or JNK inhibitor SP600125.	Reactive Oxygen Species	66-69	cyclin dependent kinase 1	Homo sapiens	140-144
20446899-2	2010	This study suggested that G2/M cell cycle arrest was triggered by ROS/NO productions with regulations of p53, p21, cell division cycle 25C (Cdc25C), Cdc2 and cyclin B1, which were able to be prevented by protein tyrosine kinase (PTK) activity inhibitor genistein or JNK inhibitor SP600125.	Genistein	253-262	cyclin dependent kinase 1	Homo sapiens	140-144
20446899-2	2010	This study suggested that G2/M cell cycle arrest was triggered by ROS/NO productions with regulations of p53, p21, cell division cycle 25C (Cdc25C), Cdc2 and cyclin B1, which were able to be prevented by protein tyrosine kinase (PTK) activity inhibitor genistein or JNK inhibitor SP600125.	pyrazolanthrone	280-288	cyclin dependent kinase 1	Homo sapiens	140-144
20112430-5	2010	Furthermore, our results showed that cotreatment with EBB and doxorubicin resulted in marked G(2)/M arrest and apoptosis of MCF-7/ADR cells, accompanied by down-regulation of the proteins cdc2/p34 and cyclin B1 and increased the levels of calcium ions.	O-(4-ethoxybutyl)berbamine	54-57	cyclin dependent kinase 1	Homo sapiens	188-192
20112430-5	2010	Furthermore, our results showed that cotreatment with EBB and doxorubicin resulted in marked G(2)/M arrest and apoptosis of MCF-7/ADR cells, accompanied by down-regulation of the proteins cdc2/p34 and cyclin B1 and increased the levels of calcium ions.	Doxorubicin	62-73	cyclin dependent kinase 1	Homo sapiens	188-192
22993588-8	2010	Treatment of cells with DA 3003-2 caused hyperphosphorylation of Cdc2 tyr(15) in cyclin B(1) and cyclin A complexes.	Tyrosine	70-73	cyclin dependent kinase 1	Homo sapiens	65-69
20514472-3	2010	Treatment with PTX-2 significantly suppressed cell proliferation and induced G2/M phase arrest through down-regulation of cyclin B1 and cdc2 expression, but also through phosphorylation of cdc25C.	pectenotoxin 2	15-20	cyclin dependent kinase 1	Homo sapiens	136-140
20368335-6	2010	C37 with alanine substitution for Thr-507 (C37/T507A) that imitated the cleavage product during staurosporine treatment interacted with Cdc2, Cdk2, cyclin A, and cyclin B1 and markedly activated cyclin B1/Cdc2.	Staurosporine	96-109	cyclin dependent kinase 1	Homo sapiens	136-140
20368335-6	2010	C37 with alanine substitution for Thr-507 (C37/T507A) that imitated the cleavage product during staurosporine treatment interacted with Cdc2, Cdk2, cyclin A, and cyclin B1 and markedly activated cyclin B1/Cdc2.	Staurosporine	96-109	cyclin dependent kinase 1	Homo sapiens	205-209
20368335-7	2010	The dephosphorylation of Thr-507 might expose the Cdc2/Cdk2-docking site in C37.	Threonine	25-28	cyclin dependent kinase 1	Homo sapiens	50-54
20368335-9	2010	Thus, this study reveals that Cdc25A is a pro-apoptotic protein that amplifies staurosporine-induced apoptosis through the activation of cyclin B1/Cdc2 by its C-terminal domain.	Staurosporine	79-92	cyclin dependent kinase 1	Homo sapiens	30-34
20368335-1	2010	Cdc25A is a dual specificity protein phosphatase that activates cyclin/cyclin-dependent protein kinase (Cdk) complexes by removing inhibitory phosphates from conserved threonine and tyrosine in Cdks.	Phosphates	142-152	cyclin dependent kinase 1	Homo sapiens	194-198
20368335-1	2010	Cdc25A is a dual specificity protein phosphatase that activates cyclin/cyclin-dependent protein kinase (Cdk) complexes by removing inhibitory phosphates from conserved threonine and tyrosine in Cdks.	Threonine	168-177	cyclin dependent kinase 1	Homo sapiens	104-107
20368335-1	2010	Cdc25A is a dual specificity protein phosphatase that activates cyclin/cyclin-dependent protein kinase (Cdk) complexes by removing inhibitory phosphates from conserved threonine and tyrosine in Cdks.	Tyrosine	182-190	cyclin dependent kinase 1	Homo sapiens	104-107
20368335-1	2010	Cdc25A is a dual specificity protein phosphatase that activates cyclin/cyclin-dependent protein kinase (Cdk) complexes by removing inhibitory phosphates from conserved threonine and tyrosine in Cdks.	Tyrosine	182-190	cyclin dependent kinase 1	Homo sapiens	194-198
20367638-6	2010	A further analysis of cell cycle-related proteins revealed that bortezomib increased the expression levels of cyclin B1, the cdc2/cyclin B complex, and the phosphorylation of all T14, Y15, and T161 residues on cdc2.	Bortezomib	64-74	cyclin dependent kinase 1	Homo sapiens	125-129
20530684-5	2010	Specifically, the cyclin E/CDK2 complex phosphorylates Cdc25C on Ser(214), leading to its premature activation, which coincides with higher cyclin B/CDK1 and Polo-like kinase 1 (PLK1) activities in an S-phase-enriched population that result in faster mitotic entry.	Serine	65-68	cyclin dependent kinase 1	Homo sapiens	149-153
20367638-6	2010	A further analysis of cell cycle-related proteins revealed that bortezomib increased the expression levels of cyclin B1, the cdc2/cyclin B complex, and the phosphorylation of all T14, Y15, and T161 residues on cdc2.	Bortezomib	64-74	cyclin dependent kinase 1	Homo sapiens	210-214
20367638-7	2010	Bortezomib also increased the ubiquitination of cyclin B1 and wee1, but inhibited the kinase activity of the cdc2/cyclin B complex.	Bortezomib	0-10	cyclin dependent kinase 1	Homo sapiens	109-113
20402549-8	2010	The G(2)/M-phase cell-cycle arrest of LNCaP cells grown in the presence of PEITC or NAC-PEITC is correlated with the downregulation of Cdk1 and cyclin B(1) protein expression.	phenethyl isothiocyanate	75-80	cyclin dependent kinase 1	Homo sapiens	135-139
20395957-0	2010	New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses.	Tyrosine	9-12	cyclin dependent kinase 1	Homo sapiens	4-8
20395957-0	2010	New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses.	Tyrosine	9-12	cyclin dependent kinase 1	Homo sapiens	74-78
20395957-2	2010	Even though the control of MPK activity has been well established with regard to the phosphorylation of Cdc2 at Thr 14 and/or Tyr 15 and Thr 161, little is known about the proteolytic control of Cdc2.	Threonine	112-115	cyclin dependent kinase 1	Homo sapiens	104-108
20395957-5	2010	Phospho-mimic mutations at the Tyr 4 residue (Y4D or Y4E) caused significant ubiquitination of Cdc2 even in the absence of PKR.	Tyrosine	31-34	cyclin dependent kinase 1	Homo sapiens	95-99
20395957-6	2010	Our findings demonstrate that (i) PKR, Ser/Thr kinase, phosphorylates its new substrate Cdc2 at the Tyr 4 residue, (ii) PKR-mediated Tyr 4-phosphorylation facilitates Cdc2 ubiquitination and proteosomal degradation, (iii) unphosphorylated Tyr 4 prevents Cdc2 ubiquitination, and (iv) downstream from p53, PKR has a crucial role in G2 arrest and triggers Cdc2 downregulation under genotoxic conditions.	Tyrosine	100-103	cyclin dependent kinase 1	Homo sapiens	88-92
20395957-6	2010	Our findings demonstrate that (i) PKR, Ser/Thr kinase, phosphorylates its new substrate Cdc2 at the Tyr 4 residue, (ii) PKR-mediated Tyr 4-phosphorylation facilitates Cdc2 ubiquitination and proteosomal degradation, (iii) unphosphorylated Tyr 4 prevents Cdc2 ubiquitination, and (iv) downstream from p53, PKR has a crucial role in G2 arrest and triggers Cdc2 downregulation under genotoxic conditions.	Tyrosine	100-103	cyclin dependent kinase 1	Homo sapiens	167-171
20395957-6	2010	Our findings demonstrate that (i) PKR, Ser/Thr kinase, phosphorylates its new substrate Cdc2 at the Tyr 4 residue, (ii) PKR-mediated Tyr 4-phosphorylation facilitates Cdc2 ubiquitination and proteosomal degradation, (iii) unphosphorylated Tyr 4 prevents Cdc2 ubiquitination, and (iv) downstream from p53, PKR has a crucial role in G2 arrest and triggers Cdc2 downregulation under genotoxic conditions.	Tyrosine	100-103	cyclin dependent kinase 1	Homo sapiens	167-171
20395957-6	2010	Our findings demonstrate that (i) PKR, Ser/Thr kinase, phosphorylates its new substrate Cdc2 at the Tyr 4 residue, (ii) PKR-mediated Tyr 4-phosphorylation facilitates Cdc2 ubiquitination and proteosomal degradation, (iii) unphosphorylated Tyr 4 prevents Cdc2 ubiquitination, and (iv) downstream from p53, PKR has a crucial role in G2 arrest and triggers Cdc2 downregulation under genotoxic conditions.	Tyrosine	100-103	cyclin dependent kinase 1	Homo sapiens	167-171
20395957-6	2010	Our findings demonstrate that (i) PKR, Ser/Thr kinase, phosphorylates its new substrate Cdc2 at the Tyr 4 residue, (ii) PKR-mediated Tyr 4-phosphorylation facilitates Cdc2 ubiquitination and proteosomal degradation, (iii) unphosphorylated Tyr 4 prevents Cdc2 ubiquitination, and (iv) downstream from p53, PKR has a crucial role in G2 arrest and triggers Cdc2 downregulation under genotoxic conditions.	Tyrosine	133-136	cyclin dependent kinase 1	Homo sapiens	88-92
20395957-6	2010	Our findings demonstrate that (i) PKR, Ser/Thr kinase, phosphorylates its new substrate Cdc2 at the Tyr 4 residue, (ii) PKR-mediated Tyr 4-phosphorylation facilitates Cdc2 ubiquitination and proteosomal degradation, (iii) unphosphorylated Tyr 4 prevents Cdc2 ubiquitination, and (iv) downstream from p53, PKR has a crucial role in G2 arrest and triggers Cdc2 downregulation under genotoxic conditions.	Tyrosine	133-136	cyclin dependent kinase 1	Homo sapiens	167-171
20395957-6	2010	Our findings demonstrate that (i) PKR, Ser/Thr kinase, phosphorylates its new substrate Cdc2 at the Tyr 4 residue, (ii) PKR-mediated Tyr 4-phosphorylation facilitates Cdc2 ubiquitination and proteosomal degradation, (iii) unphosphorylated Tyr 4 prevents Cdc2 ubiquitination, and (iv) downstream from p53, PKR has a crucial role in G2 arrest and triggers Cdc2 downregulation under genotoxic conditions.	Tyrosine	133-136	cyclin dependent kinase 1	Homo sapiens	167-171
20395957-6	2010	Our findings demonstrate that (i) PKR, Ser/Thr kinase, phosphorylates its new substrate Cdc2 at the Tyr 4 residue, (ii) PKR-mediated Tyr 4-phosphorylation facilitates Cdc2 ubiquitination and proteosomal degradation, (iii) unphosphorylated Tyr 4 prevents Cdc2 ubiquitination, and (iv) downstream from p53, PKR has a crucial role in G2 arrest and triggers Cdc2 downregulation under genotoxic conditions.	Tyrosine	133-136	cyclin dependent kinase 1	Homo sapiens	167-171
20395957-6	2010	Our findings demonstrate that (i) PKR, Ser/Thr kinase, phosphorylates its new substrate Cdc2 at the Tyr 4 residue, (ii) PKR-mediated Tyr 4-phosphorylation facilitates Cdc2 ubiquitination and proteosomal degradation, (iii) unphosphorylated Tyr 4 prevents Cdc2 ubiquitination, and (iv) downstream from p53, PKR has a crucial role in G2 arrest and triggers Cdc2 downregulation under genotoxic conditions.	Tyrosine	133-136	cyclin dependent kinase 1	Homo sapiens	88-92
20395957-6	2010	Our findings demonstrate that (i) PKR, Ser/Thr kinase, phosphorylates its new substrate Cdc2 at the Tyr 4 residue, (ii) PKR-mediated Tyr 4-phosphorylation facilitates Cdc2 ubiquitination and proteosomal degradation, (iii) unphosphorylated Tyr 4 prevents Cdc2 ubiquitination, and (iv) downstream from p53, PKR has a crucial role in G2 arrest and triggers Cdc2 downregulation under genotoxic conditions.	Tyrosine	133-136	cyclin dependent kinase 1	Homo sapiens	167-171
20395957-6	2010	Our findings demonstrate that (i) PKR, Ser/Thr kinase, phosphorylates its new substrate Cdc2 at the Tyr 4 residue, (ii) PKR-mediated Tyr 4-phosphorylation facilitates Cdc2 ubiquitination and proteosomal degradation, (iii) unphosphorylated Tyr 4 prevents Cdc2 ubiquitination, and (iv) downstream from p53, PKR has a crucial role in G2 arrest and triggers Cdc2 downregulation under genotoxic conditions.	Tyrosine	133-136	cyclin dependent kinase 1	Homo sapiens	167-171
20395957-6	2010	Our findings demonstrate that (i) PKR, Ser/Thr kinase, phosphorylates its new substrate Cdc2 at the Tyr 4 residue, (ii) PKR-mediated Tyr 4-phosphorylation facilitates Cdc2 ubiquitination and proteosomal degradation, (iii) unphosphorylated Tyr 4 prevents Cdc2 ubiquitination, and (iv) downstream from p53, PKR has a crucial role in G2 arrest and triggers Cdc2 downregulation under genotoxic conditions.	Tyrosine	133-136	cyclin dependent kinase 1	Homo sapiens	167-171
20385192-5	2010	Astaxanthin-induced activation of PI3K and its downstream mediators, p-MEK, p-ERK, and p-Stat3 in NSCs resulted in subsequent induction of expression of proliferation-related transcription factors (Rex1, CDK1, and CDK2) and stemness genes (OCT4, SOX2, Nanog, and KLF4).	astaxanthine	0-11	cyclin dependent kinase 1	Homo sapiens	204-208
20143254-0	2010	Diallyl trisulfide-induced G2/M phase cell cycle arrest in DU145 cells is associated with delayed nuclear translocation of cyclin-dependent kinase 1.	diallyl trisulfide	0-18	cyclin dependent kinase 1	Homo sapiens	123-148
20143254-9	2010	CONCLUSION: The present study indicates that the DATS-mediated G2/M phase cell cycle arrest in DU145 cells results from differential kinetics of nuclear localization of cdk1 and cyclin B1.	diallyl trisulfide	49-53	cyclin dependent kinase 1	Homo sapiens	169-173
20360007-2	2010	Activation of Cdk1 is a multistep process comprising binding of Cdk1 to cyclin B, relocation of cyclin-kinase complexes to the nucleus, activating phosphorylation of Cdk1 on Thr(161) by the Cdk-activating kinase (CAK; Cdk7 in metazoans), and removal of inhibitory Thr(14) and Tyr(15) phosphorylations.	Threonine	174-177	cyclin dependent kinase 1	Homo sapiens	14-18
20360007-2	2010	Activation of Cdk1 is a multistep process comprising binding of Cdk1 to cyclin B, relocation of cyclin-kinase complexes to the nucleus, activating phosphorylation of Cdk1 on Thr(161) by the Cdk-activating kinase (CAK; Cdk7 in metazoans), and removal of inhibitory Thr(14) and Tyr(15) phosphorylations.	Threonine	264-267	cyclin dependent kinase 1	Homo sapiens	14-18
20360007-2	2010	Activation of Cdk1 is a multistep process comprising binding of Cdk1 to cyclin B, relocation of cyclin-kinase complexes to the nucleus, activating phosphorylation of Cdk1 on Thr(161) by the Cdk-activating kinase (CAK; Cdk7 in metazoans), and removal of inhibitory Thr(14) and Tyr(15) phosphorylations.	Tyrosine	276-279	cyclin dependent kinase 1	Homo sapiens	14-18
20360007-5	2010	In Cdc25A-overexpressing cells, Cdk1 exhibits high kinase activity despite being phosphorylated on Tyr(15).	Tyrosine	99-102	cyclin dependent kinase 1	Homo sapiens	32-36
20360007-6	2010	In addition, Tyr(15)-phosphorylated Cdk1 binds more cyclin B in Cdc25A-overexpressing cells compared with control cells.	Tyrosine	13-16	cyclin dependent kinase 1	Homo sapiens	36-40
20360007-9	2010	Importantly, we find that Cdc25A overexpression leads to an activation of Cdk7 and increase in Thr(161) phosphorylation of Cdk1.	Threonine	95-98	cyclin dependent kinase 1	Homo sapiens	123-127
20034474-7	2010	Additional studies indicated that the effect of Chamaecypanone C on cell cycle arrest was associated with an increase in cyclin B1 levels and a mobility shift of Cdc2/Cdc25C.	chamaecypanone C	48-64	cyclin dependent kinase 1	Homo sapiens	162-166
20181698-0	2010	Downregulation of Cdc2/CDK1 kinase activity induces the synthesis of noninfectious human papillomavirus type 31b virions in organotypic tissues exposed to benzo[a]pyrene.	Benzo(a)pyrene	155-169	cyclin dependent kinase 1	Homo sapiens	18-22
20181698-0	2010	Downregulation of Cdc2/CDK1 kinase activity induces the synthesis of noninfectious human papillomavirus type 31b virions in organotypic tissues exposed to benzo[a]pyrene.	Benzo(a)pyrene	155-169	cyclin dependent kinase 1	Homo sapiens	23-27
20181698-5	2010	Specifically, BaP treatment increased accumulation of hyperphosphorylated retinoblastoma protein (pRb) which coincided with increased cdc2/CDK1 kinase activity, but which further conflicted with the simultaneous upregulation of CDK inhibitors p16(INK4) and p27(KIP1), which normally mediate pRb hypophosphorylation.	Benzo(a)pyrene	14-17	cyclin dependent kinase 1	Homo sapiens	134-138
20402549-8	2010	The G(2)/M-phase cell-cycle arrest of LNCaP cells grown in the presence of PEITC or NAC-PEITC is correlated with the downregulation of Cdk1 and cyclin B(1) protein expression.	nac-peitc	84-93	cyclin dependent kinase 1	Homo sapiens	135-139
20181698-5	2010	Specifically, BaP treatment increased accumulation of hyperphosphorylated retinoblastoma protein (pRb) which coincided with increased cdc2/CDK1 kinase activity, but which further conflicted with the simultaneous upregulation of CDK inhibitors p16(INK4) and p27(KIP1), which normally mediate pRb hypophosphorylation.	Benzo(a)pyrene	14-17	cyclin dependent kinase 1	Homo sapiens	139-143
20181698-8	2010	The addition of purvalanol A, a specific inhibitor of CDK1 kinase, to BaP-treated cultures, resulted in the production of noninfectious HPV type 31b (HPV31b) particles.	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	16-28	cyclin dependent kinase 1	Homo sapiens	54-58
20181698-8	2010	The addition of purvalanol A, a specific inhibitor of CDK1 kinase, to BaP-treated cultures, resulted in the production of noninfectious HPV type 31b (HPV31b) particles.	Benzo(a)pyrene	70-73	cyclin dependent kinase 1	Homo sapiens	54-58
20181698-10	2010	BaP targeting of CDK1 occurred independently of HPV status, since BaP treatment also increased CDK1 activity in tissues derived from primary keratinocytes.	Benzo(a)pyrene	0-3	cyclin dependent kinase 1	Homo sapiens	17-21
19825886-1	2010	BACKGROUND: AZD5438 is an orally bioavailable inhibitor of cyclin E-cdk2, cyclin A-cdk2 and cyclin B-cdk1 complexes.	AZD5438	12-19	cyclin dependent kinase 1	Homo sapiens	101-105
20181698-10	2010	BaP targeting of CDK1 occurred independently of HPV status, since BaP treatment also increased CDK1 activity in tissues derived from primary keratinocytes.	Benzo(a)pyrene	66-69	cyclin dependent kinase 1	Homo sapiens	95-99
20181698-11	2010	Our data indicate that HPV31b virions synthesized in the presence of BaP were dependent on BaP-mediated alteration in CDK1 kinase activity for maintaining their infectivity.	Benzo(a)pyrene	69-72	cyclin dependent kinase 1	Homo sapiens	118-122
20181698-11	2010	Our data indicate that HPV31b virions synthesized in the presence of BaP were dependent on BaP-mediated alteration in CDK1 kinase activity for maintaining their infectivity.	Benzo(a)pyrene	91-94	cyclin dependent kinase 1	Homo sapiens	118-122
19795419-8	2010	The latter correlated well with upregulation of cyclin D3 and p21(Waf1/Cip1) as well as with inhibition of cdc2 activity through Tyr-15 phosphorylation.	Tyrosine	129-132	cyclin dependent kinase 1	Homo sapiens	107-111
20107315-6	2010	MK-1775 inhibited CDC2 Y15 phosphorylation in cells, abrogated DNA damaged checkpoints induced by 5-FU treatment, and caused premature entry of mitosis determined by induction of Histone H3 phosphorylation.	adavosertib	0-7	cyclin dependent kinase 1	Homo sapiens	18-22
20110807-2	2010	Cucurbitacin E at low concentrations (3-50 nmol/l) inhibited the growth of HL-60 cells, which was associated with G2/M cell-cycle arrest, decrease in the levels of cyclin-dependent kinase1, and increase in the levels of p21.	cucurbitacin E	0-14	cyclin dependent kinase 1	Homo sapiens	164-188
20110807-8	2010	As phosphorylated eIF2 is an inhibitor of protein translation initiation, our data suggest that cucurbitacin E induces cell growth arrest and apoptosis through the induction of eIF2 phosphorylation, which leads to the inhibition of cyclin-dependent kinase 1, Mcl-1, survivin, and/or XIAP protein synthesis and that cucurbitacin E induces apoptosis mainly through a mitochondrial-mediated pathway.	cucurbitacin E	96-110	cyclin dependent kinase 1	Homo sapiens	232-257
20110807-8	2010	As phosphorylated eIF2 is an inhibitor of protein translation initiation, our data suggest that cucurbitacin E induces cell growth arrest and apoptosis through the induction of eIF2 phosphorylation, which leads to the inhibition of cyclin-dependent kinase 1, Mcl-1, survivin, and/or XIAP protein synthesis and that cucurbitacin E induces apoptosis mainly through a mitochondrial-mediated pathway.	cucurbitacin E	315-329	cyclin dependent kinase 1	Homo sapiens	232-257
20110360-5	2010	BGLF4 is an EBV-encoded kinase and has similar kinase activity to cdc2, an important kinase that phosphorylates serine residues 25 and 38 of stathmin during mitosis.	Serine	112-118	cyclin dependent kinase 1	Homo sapiens	66-70
20172609-2	2010	48-h serum deprival, and a 24-h treatment with 1 mM hydroxyurea or with 10 microM RO-3306--a cyclin-dependent kinase 1 inhibitor--induced cell cycle block in G1, S and G2/M, respectively.	RO 3306	82-89	cyclin dependent kinase 1	Homo sapiens	93-118
20071461-4	2010	Administration of everolimus, a potent inhibitor of mammalian target of rapamycin, markedly reduced compensatory hypertrophy and hyperplasia of epithelial cells, which was accompanied by complete abolishment of the expression of Cyclin B2 and Cdc2 enhancement; renal function was then severely decreased.	Everolimus	18-28	cyclin dependent kinase 1	Homo sapiens	243-247
20062077-0	2010	SP600125 suppresses Cdk1 and induces endoreplication directly from G2 phase, independent of JNK inhibition.	pyrazolanthrone	0-8	cyclin dependent kinase 1	Homo sapiens	20-24
20171170-10	2010	We identified the Ser(208) residue of Aki1 as a cyclin B1-Cdk1 phosphorylation site.	Serine	18-21	cyclin dependent kinase 1	Homo sapiens	58-62
20062077-8	2010	Instead, the inhibitory effect of SP600125 on mitotic entry predominantly occurs upstream of Aurora A kinase and Polo-like kinase 1, resulting in a failure to remove the inhibitory phosphorylation of Cdk1.	pyrazolanthrone	34-42	cyclin dependent kinase 1	Homo sapiens	200-204
20163671-7	2010	By additional treatment with LY294002 after Ca(2+) ionophore, both the MAPK and p34(cdc2) kinase activities were decreased in a time-dependent manner, concomitantly with improvement of pronuclear formation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	cyclin dependent kinase 1	Homo sapiens	84-88
19727814-9	2010	When wild type p53 expression was specifically inhibited by RNA-interference, A549 cells treated with MONCPT delayed the onset of G2/M arrest; meanwhile p-ERK and Cdc2 were up-regulated while p21 and CDK7 were down-regulated in A549 cells treated with MONCPT and p53 SiRNA transfection in contrast to cells treated with 100.0 nM MONCPT alone.	10-methoxy-9-nitrocamptothecin	102-108	cyclin dependent kinase 1	Homo sapiens	163-167
20163670-6	2010	Following completion of maturation, inactivation of MAPK by U0126 did not affect IP(3)R1 phosphorylation, although inactivation of p34(cdc2) kinase by roscovitine dramatically reduced IP(3)R1 phosphorylation.	Roscovitine	151-162	cyclin dependent kinase 1	Homo sapiens	135-139
19643530-4	2010	Additionally, butein treatment enhanced inactivated phospho-Cdc2 levels, reduced Cdc2 kinase activity, and generated reactive oxygen species (ROS) that was accompanied by JNK activation.	butein	14-20	cyclin dependent kinase 1	Homo sapiens	60-64
19643530-4	2010	Additionally, butein treatment enhanced inactivated phospho-Cdc2 levels, reduced Cdc2 kinase activity, and generated reactive oxygen species (ROS) that was accompanied by JNK activation.	butein	14-20	cyclin dependent kinase 1	Homo sapiens	81-85
20163671-3	2010	In this study the effect of a PI3K inhibitor, LY294002, on the MAPK and p34(cdc2) kinase activities of matured porcine oocytes was examined.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	cyclin dependent kinase 1	Homo sapiens	76-80
19781537-10	2010	We also found that the combination of ATO and PTX at low concentrations synergistically induced mitotic arrest followed by apoptosis in malignant lymphocytes, which increased phosphorylated cyclin-dependent kinase 1 (Cdk1) on Thr(161) and promoted the dysregulated activation of Cdk1.	Arsenic Trioxide	38-41	cyclin dependent kinase 1	Homo sapiens	190-215
20163671-5	2010	Although 25 micromol/L LY294002 did not affect either the MAPK or p34(cdc2) kinase activities, 50 micromol/L LY294002 suppressed the PKB phosphorylation and slightly decreased MAPK activity, but not the p34(cdc2) kinase activity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	cyclin dependent kinase 1	Homo sapiens	207-211
20163671-6	2010	Therefore the effect of 10 micromol/L Ca(2+) ionophore which was reported as inducing a transient decrease of p34(cdc2) kinase but not MAPK activities, was also examined in LY294002-treated oocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	173-181	cyclin dependent kinase 1	Homo sapiens	114-118
20083600-1	2010	After a long period of quiescence at dictyate prophase I, termed the germinal vesicle (GV) stage, mammalian oocytes reenter meiosis by activating the Cdc2-cyclin B complex (maturation-promoting factor [MPF]).	dictyate	37-45	cyclin dependent kinase 1	Homo sapiens	150-154
19917613-4	2010	Consistent with a G(2)/M arrest, PKCdelta-cat induced phosphorylation of Cdk1 (Tyr(15)), a critical event in the G(2)/M checkpoint.	Tyrosine	79-82	cyclin dependent kinase 1	Homo sapiens	73-77
19781537-10	2010	We also found that the combination of ATO and PTX at low concentrations synergistically induced mitotic arrest followed by apoptosis in malignant lymphocytes, which increased phosphorylated cyclin-dependent kinase 1 (Cdk1) on Thr(161) and promoted the dysregulated activation of Cdk1.	Arsenic Trioxide	38-41	cyclin dependent kinase 1	Homo sapiens	217-221
19781537-10	2010	We also found that the combination of ATO and PTX at low concentrations synergistically induced mitotic arrest followed by apoptosis in malignant lymphocytes, which increased phosphorylated cyclin-dependent kinase 1 (Cdk1) on Thr(161) and promoted the dysregulated activation of Cdk1.	Arsenic Trioxide	38-41	cyclin dependent kinase 1	Homo sapiens	279-283
19781537-10	2010	We also found that the combination of ATO and PTX at low concentrations synergistically induced mitotic arrest followed by apoptosis in malignant lymphocytes, which increased phosphorylated cyclin-dependent kinase 1 (Cdk1) on Thr(161) and promoted the dysregulated activation of Cdk1.	Paclitaxel	46-49	cyclin dependent kinase 1	Homo sapiens	190-215
19781537-10	2010	We also found that the combination of ATO and PTX at low concentrations synergistically induced mitotic arrest followed by apoptosis in malignant lymphocytes, which increased phosphorylated cyclin-dependent kinase 1 (Cdk1) on Thr(161) and promoted the dysregulated activation of Cdk1.	Paclitaxel	46-49	cyclin dependent kinase 1	Homo sapiens	217-221
19781537-10	2010	We also found that the combination of ATO and PTX at low concentrations synergistically induced mitotic arrest followed by apoptosis in malignant lymphocytes, which increased phosphorylated cyclin-dependent kinase 1 (Cdk1) on Thr(161) and promoted the dysregulated activation of Cdk1.	Paclitaxel	46-49	cyclin dependent kinase 1	Homo sapiens	279-283
19781537-10	2010	We also found that the combination of ATO and PTX at low concentrations synergistically induced mitotic arrest followed by apoptosis in malignant lymphocytes, which increased phosphorylated cyclin-dependent kinase 1 (Cdk1) on Thr(161) and promoted the dysregulated activation of Cdk1.	Threonine	226-229	cyclin dependent kinase 1	Homo sapiens	190-215
19781537-10	2010	We also found that the combination of ATO and PTX at low concentrations synergistically induced mitotic arrest followed by apoptosis in malignant lymphocytes, which increased phosphorylated cyclin-dependent kinase 1 (Cdk1) on Thr(161) and promoted the dysregulated activation of Cdk1.	Threonine	226-229	cyclin dependent kinase 1	Homo sapiens	217-221
19875160-9	2010	SAHA increased expression of p21cip1/waf1 and p27Kip1, down regulated cyclins A and B, and suppressed CDK1.	Vorinostat	0-4	cyclin dependent kinase 1	Homo sapiens	102-106
19879023-4	2010	Quinolin-4-yl-substituted compound, 8, presents cytotoxic activity and is most effective and selective against CDK1/CycA than against CDK2/CycB.	quinolin-4-yl	0-13	cyclin dependent kinase 1	Homo sapiens	111-115
20339515-5	2010	Finally, the DHAP/DAHC matrix was applied to identify phosphorylation sites from alpha-casein and beta-casein and to characterize two phosphorylation sites from the human histone H1 treated with Cyclin-Dependent Kinase-1 (CDK1) by MALDI-TOF/TOF MS.	Dihydroxyacetone Phosphate	13-17	cyclin dependent kinase 1	Homo sapiens	195-220
20339515-5	2010	Finally, the DHAP/DAHC matrix was applied to identify phosphorylation sites from alpha-casein and beta-casein and to characterize two phosphorylation sites from the human histone H1 treated with Cyclin-Dependent Kinase-1 (CDK1) by MALDI-TOF/TOF MS.	Dihydroxyacetone Phosphate	13-17	cyclin dependent kinase 1	Homo sapiens	222-226
19858290-2	2010	Inactivating human cyclin A/Cdk2 complexes through diverse approaches delays mitotic entry and promotes inhibitory phosphorylation of Cdk1 on tyrosine 15, a modification performed by Wee1.	Tyrosine	142-150	cyclin dependent kinase 1	Homo sapiens	134-138
19408974-10	2010	This 17-AAG-induced potentiation of DNA crosslinking agent-induced cytotoxicity was a consequence of prolonged G(2)-M arrest accompanied by the suppression of cdc2 and cdc25C and of increased apoptotic cell death accompanied by the degradation of the antiapoptosis proteins Akt and survivin.	tanespimycin	5-11	cyclin dependent kinase 1	Homo sapiens	159-163
19732843-6	2009	It is also shown that genistein increases the phosphorylation and activation of Chk1 and Chk2, which results in the phosphorylation and inactivation of phosphatases Cdc25C and Cdc25A, and thereby the phosphorylation and inactivation of Cdc2 which arrests cells in G2/M phase.	Genistein	22-31	cyclin dependent kinase 1	Homo sapiens	165-169
19735649-6	2009	Concomitantly, oxaliplatin-induced G2/M arrest was associated with a reduction in both cyclin B1 expression and phosphorylated-CDC2 (Thr-161).	Oxaliplatin	15-26	cyclin dependent kinase 1	Homo sapiens	127-131
19735649-6	2009	Concomitantly, oxaliplatin-induced G2/M arrest was associated with a reduction in both cyclin B1 expression and phosphorylated-CDC2 (Thr-161).	Threonine	133-136	cyclin dependent kinase 1	Homo sapiens	127-131
19837665-3	2009	We reported recently that Chk1 is phosphorylated at Ser(286) and Ser(301) by Cdk1 during mitosis.	Serine	52-55	cyclin dependent kinase 1	Homo sapiens	77-81
19837665-3	2009	We reported recently that Chk1 is phosphorylated at Ser(286) and Ser(301) by Cdk1 during mitosis.	Serine	65-68	cyclin dependent kinase 1	Homo sapiens	77-81
20574922-4	2010	Cell cycle check point proteins such as p21 and stratifin (14-3-3 sigma) increased at mRNA and protein level, whereas cell cycle progression proteins such as cell division cycle 25 homolog and cyclin-dependent kinase 1 decreased after DHA treatment.	Docosahexaenoic Acids	235-238	cyclin dependent kinase 1	Homo sapiens	193-218
19589639-6	2009	Furthermore, gallic acid is shown to block the growth of DU145 cells at G2/M phases by activating Chk1 and Chk2 and inhibiting Cdc25C and Cdc2 activities.	Gallic Acid	13-24	cyclin dependent kinase 1	Homo sapiens	127-131
19821535-6	2009	Furthermore, in hepatocytes arrested by the iron chelator O-Trensox in early S-phase prior to DNA replication, Cdk1/cyclin complexes were active, while replication initiation components such as the minichromosome maintenance 7 (Mcm7) protein were loaded onto DNA.	Iron	44-48	cyclin dependent kinase 1	Homo sapiens	111-115
19996705-10	2009	The anti-proliferative activity of CS and PS was accompanied by inhibition of cyclin B1, and Cdc 2 mRNA.	Cesium	35-37	cyclin dependent kinase 1	Homo sapiens	93-98
19039521-7	2009	Bortezomib alone or in combination with taxol induced a cell cycle arrest within the S phase, and downregulation of cdk1, a cyclin-dependent kinase that is necessary for the entry into the M phase.	Bortezomib	0-10	cyclin dependent kinase 1	Homo sapiens	116-120
19039521-7	2009	Bortezomib alone or in combination with taxol induced a cell cycle arrest within the S phase, and downregulation of cdk1, a cyclin-dependent kinase that is necessary for the entry into the M phase.	Paclitaxel	40-45	cyclin dependent kinase 1	Homo sapiens	116-120
19822658-2	2009	Inhibition of cyclin-dependent kinase 1 (CDK1) with the specific inhibitor RO3306 is sufficient to trigger multiple rounds of genome reduplication.	RO 3306	75-81	cyclin dependent kinase 1	Homo sapiens	14-39
19822658-2	2009	Inhibition of cyclin-dependent kinase 1 (CDK1) with the specific inhibitor RO3306 is sufficient to trigger multiple rounds of genome reduplication.	RO 3306	75-81	cyclin dependent kinase 1	Homo sapiens	41-45
20095141-8	2009	Moreover, MONCPT exposure (0.1 microM, 24 h) caused down-regulation of CDK7, p-Cdc2, and cyclinB1.	10-methoxy-9-nitrocamptothecin	10-16	cyclin dependent kinase 1	Homo sapiens	79-83
19602434-8	2009	Moreover, upon sodium selenite treatment, there was a tendency for cells to accumulate at G2 phase which was accompanied by the increasing expression of cyclin B1, Cdc2 p34, p21 and the sub G1 fraction of the cell cycle.	Sodium Selenite	15-30	cyclin dependent kinase 1	Homo sapiens	164-168
19996705-10	2009	The anti-proliferative activity of CS and PS was accompanied by inhibition of cyclin B1, and Cdc 2 mRNA.	ps	42-44	cyclin dependent kinase 1	Homo sapiens	93-98
19705844-5	2009	In addition, tricetin-mediated G2/M phase arrest was also associated with decreases in the amounts of cyclin B, cyclin A, cdc2 and cdc25C, and increases in the phosphorylation of Chk2, cdc25C and cdc2.	tricetin	13-21	cyclin dependent kinase 1	Homo sapiens	122-126
19737929-7	2009	We demonstrate that the Ser-251 residue is required for CDK1-dependent phosphorylation of FoxM1 as well as its interaction with the coactivator CREB-binding protein (CBP).	Serine	24-27	cyclin dependent kinase 1	Homo sapiens	56-60
19730412-2	2009	We show here that the mitosis-promoting kinase, cdk1-cyclin B1, suppresses apoptosis upstream of mitochondrial cytochrome c release by phosphorylating caspase-2 within an evolutionarily conserved sequence at Ser 340.	Serine	208-211	cyclin dependent kinase 1	Homo sapiens	48-52
19375851-4	2009	Both doxorubicin (DOX) and dinitro-phenyl S-glutathione (DNP-SG) transport were inhibited by cdc2 in a concentration dependent manner.	Doxorubicin	5-16	cyclin dependent kinase 1	Homo sapiens	93-97
19375851-4	2009	Both doxorubicin (DOX) and dinitro-phenyl S-glutathione (DNP-SG) transport were inhibited by cdc2 in a concentration dependent manner.	Doxorubicin	18-21	cyclin dependent kinase 1	Homo sapiens	93-97
19375851-4	2009	Both doxorubicin (DOX) and dinitro-phenyl S-glutathione (DNP-SG) transport were inhibited by cdc2 in a concentration dependent manner.	S-(2,4-dinitrophenyl)glutathione	27-55	cyclin dependent kinase 1	Homo sapiens	93-97
19375851-4	2009	Both doxorubicin (DOX) and dinitro-phenyl S-glutathione (DNP-SG) transport were inhibited by cdc2 in a concentration dependent manner.	2,4-Dinitrophenol	57-60	cyclin dependent kinase 1	Homo sapiens	93-97
19375851-5	2009	Liposomal delivery of cdc2 to H358 cells caused apoptosis, resulted in an increased intracellular doxorubicin-accumulation and decreased rate of efflux from the cells.	Doxorubicin	98-109	cyclin dependent kinase 1	Homo sapiens	22-26
19725879-6	2009	In addition, we found that the cysteine-rich CXC domain of LIN54 is a novel DNA-binding domain that binds to the cdc2 promoter in a sequence-specific manner.	Cysteine	31-39	cyclin dependent kinase 1	Homo sapiens	113-117
19530246-4	2009	This resulted in Cdk1 tyrosine phosphorylation at Tyr-15, leading to cell cycle block at G2/M phase.	Tyrosine	22-30	cyclin dependent kinase 1	Homo sapiens	17-21
19530246-4	2009	This resulted in Cdk1 tyrosine phosphorylation at Tyr-15, leading to cell cycle block at G2/M phase.	Tyrosine	50-53	cyclin dependent kinase 1	Homo sapiens	17-21
19633130-10	2009	Moreover, the activity of the cyclin-dependent kinase 1 (CDK1) and MAP kinase declined when SH-6-treated DOs underwent GVBD, indicating that AKT activity is involved in the regulation of CDK1 and MAP kinase.	sanguiin H 6	92-96	cyclin dependent kinase 1	Homo sapiens	30-55
19633130-10	2009	Moreover, the activity of the cyclin-dependent kinase 1 (CDK1) and MAP kinase declined when SH-6-treated DOs underwent GVBD, indicating that AKT activity is involved in the regulation of CDK1 and MAP kinase.	sanguiin H 6	92-96	cyclin dependent kinase 1	Homo sapiens	57-61
19633130-10	2009	Moreover, the activity of the cyclin-dependent kinase 1 (CDK1) and MAP kinase declined when SH-6-treated DOs underwent GVBD, indicating that AKT activity is involved in the regulation of CDK1 and MAP kinase.	sanguiin H 6	92-96	cyclin dependent kinase 1	Homo sapiens	187-191
19699753-3	2009	KEY FINDINGS: IQDMA-induced G(2)/M arrest was associated with a marked decrease in the protein expressions of cyclin A, cyclin B, and cyclin-dependent kinase (Cdk)1.	N'-(11H-indolo(3,2-c)quinolin-6-yl)-N,N-dimethylethane-1,2-diamine	14-19	cyclin dependent kinase 1	Homo sapiens	159-164
19560278-0	2009	Stress hormones mediate drug resistance to paclitaxel in human breast cancer cells through a CDK-1-dependent pathway.	Paclitaxel	43-53	cyclin dependent kinase 1	Homo sapiens	93-98
19560278-7	2009	Inhibition of CDK-1 abrogated stress hormone-mediated reversal of paclitaxel-induced cytotoxicity, indicating that the protective effect of stress hormones act through a CDK-1-dependent mechanism.	Paclitaxel	66-76	cyclin dependent kinase 1	Homo sapiens	14-19
19560278-7	2009	Inhibition of CDK-1 abrogated stress hormone-mediated reversal of paclitaxel-induced cytotoxicity, indicating that the protective effect of stress hormones act through a CDK-1-dependent mechanism.	Paclitaxel	66-76	cyclin dependent kinase 1	Homo sapiens	170-175
19687009-4	2009	We show that Cdc2 interacts with CLIP-170 mediating its phosphorylation on Thr(287) in vivo.	Threonine	75-78	cyclin dependent kinase 1	Homo sapiens	13-17
19699753-7	2009	Both SP600125 and SB203580 attenuated the activation of Bax and cytochrome c release, and reversed down-regulation of Bcl-2, XIAP, survivin, cyclin A, cyclin B, and Cdk1 in IQDMA-treated cells.	pyrazolanthrone	5-13	cyclin dependent kinase 1	Homo sapiens	165-169
19705844-5	2009	In addition, tricetin-mediated G2/M phase arrest was also associated with decreases in the amounts of cyclin B, cyclin A, cdc2 and cdc25C, and increases in the phosphorylation of Chk2, cdc25C and cdc2.	tricetin	13-21	cyclin dependent kinase 1	Homo sapiens	131-135
19699753-7	2009	Both SP600125 and SB203580 attenuated the activation of Bax and cytochrome c release, and reversed down-regulation of Bcl-2, XIAP, survivin, cyclin A, cyclin B, and Cdk1 in IQDMA-treated cells.	SB 203580	18-26	cyclin dependent kinase 1	Homo sapiens	165-169
19730430-5	2009	LGH00031 increased cyclin-dependent kinase 1 (CDK1) tyrosine 15 phosphorylation and cyclin B1 protein level.	Tyrosine	52-60	cyclin dependent kinase 1	Homo sapiens	19-44
19527713-4	2009	During bleomycin-induced over-replication, mitotic entry is inhibited through tyrosine phosphorylation of CDK1 along the ATM/ATR pathway in the early phase of treatment.	Bleomycin	7-16	cyclin dependent kinase 1	Homo sapiens	106-110
19527713-4	2009	During bleomycin-induced over-replication, mitotic entry is inhibited through tyrosine phosphorylation of CDK1 along the ATM/ATR pathway in the early phase of treatment.	Tyrosine	78-86	cyclin dependent kinase 1	Homo sapiens	106-110
19730430-5	2009	LGH00031 increased cyclin-dependent kinase 1 (CDK1) tyrosine 15 phosphorylation and cyclin B1 protein level.	Tyrosine	52-60	cyclin dependent kinase 1	Homo sapiens	46-50
19730430-9	2009	Correspondingly, the LGH00031-induced decrease in cell viability and cell cycle arrest, cyclin B1 protein level, and phosphorylation of CDK1 tyrosine 15 were also rescued by NAC that decreased ROS production.	Tyrosine	141-149	cyclin dependent kinase 1	Homo sapiens	136-140
19730430-9	2009	Correspondingly, the LGH00031-induced decrease in cell viability and cell cycle arrest, cyclin B1 protein level, and phosphorylation of CDK1 tyrosine 15 were also rescued by NAC that decreased ROS production.	Acetylcysteine	174-177	cyclin dependent kinase 1	Homo sapiens	136-140
19661327-6	2009	Western blotting and CDK1 kinase assay showed that CWC-8 treatment caused a time-dependent increase of Cyclin B and CDK1 protein levels and activity during G(2)/M arrest.	cwc-8	51-56	cyclin dependent kinase 1	Homo sapiens	21-25
19661327-6	2009	Western blotting and CDK1 kinase assay showed that CWC-8 treatment caused a time-dependent increase of Cyclin B and CDK1 protein levels and activity during G(2)/M arrest.	cwc-8	51-56	cyclin dependent kinase 1	Homo sapiens	116-120
19082595-5	2009	Studies were performed to determine whether 17-AAG-mediated cdc2 decrease was due to altered gene expression, transcription, or protein degradation.	tanespimycin	44-50	cyclin dependent kinase 1	Homo sapiens	60-64
19082595-8	2009	Cells treated with 17-AAG also showed an increased fraction in G(2)/M phase and an associated decrease in cdc2 through protein degradation rather than through other mechanisms.	tanespimycin	19-25	cyclin dependent kinase 1	Homo sapiens	106-110
19082595-9	2009	Hsp90 inhibition by 17-AAG also decreased HCC xenograft growth in association with decreased cdc2 expression.	tanespimycin	20-26	cyclin dependent kinase 1	Homo sapiens	93-97
19082595-10	2009	CONCLUSIONS: 17-AAG-mediated inhibition of Hsp90 abrogates human HCC cell growth in vitro and in vivo through cdc2 decrease, which in turn induces G(2)/M cell cycle arrest and apoptosis.	tanespimycin	13-19	cyclin dependent kinase 1	Homo sapiens	110-114
19686685-6	2009	Phosphorylation of Ase1 by Cdk1 (cyclin-dependent kinase) inhibits Cin8 binding to iMTs, preventing bending and collapse of the metaphase spindle.	cin8	67-71	cyclin dependent kinase 1	Homo sapiens	27-31
19230027-4	2009	R-roscovitine induced cell cycle arrest in G2/M phase in all cells analyzed possibly by inhibiting the CDK1-cyclin B1 complex.	Roscovitine	0-13	cyclin dependent kinase 1	Homo sapiens	103-107
19340872-5	2009	RESULTS: D-allose had inhibitory effects on all 3 cell lines and tended to upregulate mRNA expression of glucose transporters, p21 and p53, and downregulate mRNA expression of cyclin A2, cyclin B1, and CDC2.	allose	9-17	cyclin dependent kinase 1	Homo sapiens	202-206
19509270-0	2009	AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts.	AZD5438	0-7	cyclin dependent kinase 1	Homo sapiens	36-72
19509270-2	2009	We have developed AZD5438, a 4-(1-isopropyl-2-methylimidazol-5-yl)-2-(4-methylsulphonylanilino) pyrimidine, as a potent inhibitor of cyclin-dependent kinase (cdk) 1, 2, and 9 (IC(50), 16, 6, and 20 nmol/L, respectively).	AZD5438	18-25	cyclin dependent kinase 1	Homo sapiens	133-174
19509270-2	2009	We have developed AZD5438, a 4-(1-isopropyl-2-methylimidazol-5-yl)-2-(4-methylsulphonylanilino) pyrimidine, as a potent inhibitor of cyclin-dependent kinase (cdk) 1, 2, and 9 (IC(50), 16, 6, and 20 nmol/L, respectively).	4-(1-isopropyl-2-methylimidazol-5-yl)-2-(4-methylsulphonylanilino) pyrimidine	29-106	cyclin dependent kinase 1	Homo sapiens	133-174
19369249-7	2009	Among these, Thr-622 was specifically phosphorylated by Cdk1-cyclin B1 both in vitro and in vivo.	Threonine	13-16	cyclin dependent kinase 1	Homo sapiens	56-60
19276868-10	2009	We further demonstrate that UA62784 induces CDC2 kinase activity preferentially in DPC4-negative cells.	UA 62784	28-35	cyclin dependent kinase 1	Homo sapiens	44-48
19415659-0	2009	N-(indazolyl)benzamido derivatives as CDK1 inhibitors: design, synthesis, biological activity, and molecular docking studies.	n-(indazolyl)benzamido	0-22	cyclin dependent kinase 1	Homo sapiens	38-42
19401701-8	2009	Concomitant decrease in the expressions of cyclin B1 and Cdk1 were seen in curcumin-treated cells.	Curcumin	75-83	cyclin dependent kinase 1	Homo sapiens	57-61
19415659-1	2009	A series of N-1H-indazole-1-carboxamides has been synthesized and their effects on both CDK1/cyclin B and the K-562 (human chronic myelogenus leukemia) cell line were evaluated.	n-1h-indazole-1-carboxamides	12-40	cyclin dependent kinase 1	Homo sapiens	88-92
19396163-6	2009	As Cdc2 levels drop after cyclin B degradation, auto-dephosphorylation of PP1 at its Cdc2 phosphorylation site (Thr 320) allows partial PP1 activation.	Threonine	112-115	cyclin dependent kinase 1	Homo sapiens	3-7
19396163-6	2009	As Cdc2 levels drop after cyclin B degradation, auto-dephosphorylation of PP1 at its Cdc2 phosphorylation site (Thr 320) allows partial PP1 activation.	Threonine	112-115	cyclin dependent kinase 1	Homo sapiens	85-89
19229861-7	2009	Furthermore, our results suggest that decreased levels of cdc2/cyclin B1 and cdc2 kinase activity are responsible for Br-Nos-induced mitotic cell arrest leading to cell death in MCF10A-CSC3 cells.	Bromine	118-120	cyclin dependent kinase 1	Homo sapiens	58-62
19317452-1	2009	The series of 4-(benzylaminomethylene)isoquinoline-1,3-(2H,4H)-dione and 4-[(pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-dione derivatives reported here represents a novel class of potential antitumor agents, which potently and selectively inhibit CDK4 over CDK2 and CDK1.	4-(benzylaminomethylene)isoquinoline-1,3-(2h,4h)-dione	14-68	cyclin dependent kinase 1	Homo sapiens	277-281
19317452-1	2009	The series of 4-(benzylaminomethylene)isoquinoline-1,3-(2H,4H)-dione and 4-[(pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-dione derivatives reported here represents a novel class of potential antitumor agents, which potently and selectively inhibit CDK4 over CDK2 and CDK1.	4-[(pyridylmethyl)aminomethylene]isoquinoline-1,3-(2h,4h)-dione	73-136	cyclin dependent kinase 1	Homo sapiens	277-281
19254688-4	2009	Following treatment of HepG2 cells with asparanin A, cell cycle-related proteins such as cyclin A, Cdk1 and Cdk4 were down-regulated, while p21(WAF1/Cip1) and p-Cdk1 (Thr14/Tyr15) were up-regulated.	asparanin A	40-51	cyclin dependent kinase 1	Homo sapiens	99-103
19254688-4	2009	Following treatment of HepG2 cells with asparanin A, cell cycle-related proteins such as cyclin A, Cdk1 and Cdk4 were down-regulated, while p21(WAF1/Cip1) and p-Cdk1 (Thr14/Tyr15) were up-regulated.	asparanin A	40-51	cyclin dependent kinase 1	Homo sapiens	161-165
19229861-7	2009	Furthermore, our results suggest that decreased levels of cdc2/cyclin B1 and cdc2 kinase activity are responsible for Br-Nos-induced mitotic cell arrest leading to cell death in MCF10A-CSC3 cells.	Bromine	118-120	cyclin dependent kinase 1	Homo sapiens	77-81
19414386-7	2009	Consequently gnidimacrin inhibited cell growth through G(2)-phase arrest not only by the p21(WAF1/Cip1)-dependent suppression of cdc2 activity, but also by subsequent transcriptional suppression of cdc2 itself.	gnidimacrin	13-24	cyclin dependent kinase 1	Homo sapiens	129-133
19414386-0	2009	G2-phase arrest through p21(WAF1 / Cip1) induction and cdc2 repression by gnidimacrin in human hepatoma HLE cells.	gnidimacrin	74-85	cyclin dependent kinase 1	Homo sapiens	55-59
19414386-7	2009	Consequently gnidimacrin inhibited cell growth through G(2)-phase arrest not only by the p21(WAF1/Cip1)-dependent suppression of cdc2 activity, but also by subsequent transcriptional suppression of cdc2 itself.	gnidimacrin	13-24	cyclin dependent kinase 1	Homo sapiens	198-202
19414386-4	2009	However, PKC betaII gene-transfected HLE (HLE/PKC betaII) cells became sensitive to gnidimacrin, through which cdc2 inhibition and G(2)-phase arrest was caused.	gnidimacrin	84-95	cyclin dependent kinase 1	Homo sapiens	111-115
19414386-8	2009	In addition, involvement of E2F-4 in cdc2 suppression through a long-lasting induction of p21(WAF1/Cip1) by gnidimacrin is suggested in HLE/PKC betaII cells.	gnidimacrin	108-119	cyclin dependent kinase 1	Homo sapiens	37-41
19414386-5	2009	p21(WAF1/Cip1) induction and cdc2 reduction were observed and this reduction was abolished through the suppression of p21(WAF1/Cip1) induction by the MEK1/2 inhibitor U0126.	U 0126	167-172	cyclin dependent kinase 1	Homo sapiens	29-33
19211765-3	2009	Here, we show that 16E1--E4 is phosphorylated by cyclin-dependent kinase 1 (CDK1) and CDK2, extracellular signal-regulated kinase (ERK), protein kinase A (PKA), and PKC alpha, with CDK1/2 serine 32 and ERK threonine 57 phosphorylations representing the two primary events seen in cells in cycle.	Serine	188-194	cyclin dependent kinase 1	Homo sapiens	49-74
19185564-1	2009	Although the primary response to Adriamycin (doxorubicin) in p53 mutant MDA-MB231 and p53 null MCF-7/E6 breast tumor cells is apoptotic cell death, the residual surviving population appears to be in a state of senescence, based on cell morphology, beta galactosidase staining, induction of p21(waf1/cip1) and down regulation of cdc2/cdk1.	Doxorubicin	33-43	cyclin dependent kinase 1	Homo sapiens	328-332
19185564-1	2009	Although the primary response to Adriamycin (doxorubicin) in p53 mutant MDA-MB231 and p53 null MCF-7/E6 breast tumor cells is apoptotic cell death, the residual surviving population appears to be in a state of senescence, based on cell morphology, beta galactosidase staining, induction of p21(waf1/cip1) and down regulation of cdc2/cdk1.	Doxorubicin	33-43	cyclin dependent kinase 1	Homo sapiens	333-337
19185564-1	2009	Although the primary response to Adriamycin (doxorubicin) in p53 mutant MDA-MB231 and p53 null MCF-7/E6 breast tumor cells is apoptotic cell death, the residual surviving population appears to be in a state of senescence, based on cell morphology, beta galactosidase staining, induction of p21(waf1/cip1) and down regulation of cdc2/cdk1.	Doxorubicin	45-56	cyclin dependent kinase 1	Homo sapiens	328-332
19185564-1	2009	Although the primary response to Adriamycin (doxorubicin) in p53 mutant MDA-MB231 and p53 null MCF-7/E6 breast tumor cells is apoptotic cell death, the residual surviving population appears to be in a state of senescence, based on cell morphology, beta galactosidase staining, induction of p21(waf1/cip1) and down regulation of cdc2/cdk1.	Doxorubicin	45-56	cyclin dependent kinase 1	Homo sapiens	333-337
19185564-6	2009	Taken together, these studies suggest that accelerated senescence induced by Adriamycin is similar in cells with wild type p53 and in cells lacking functional p53 with regard to the upregulation of p21(waf1/cip1), down regulation of cdc2 and the involvement of reactive oxygen species.	Doxorubicin	77-87	cyclin dependent kinase 1	Homo sapiens	233-237
19287963-8	2009	In addition, blocking survivin phosphorylation at a threonine residue by inhibiting cyclin-dependent kinase 1 caused the dissociation of aurora-B kinase from survivin and attenuated the up-regulation of hTERT expression by survivin.	Threonine	52-61	cyclin dependent kinase 1	Homo sapiens	84-109
19211765-3	2009	Here, we show that 16E1--E4 is phosphorylated by cyclin-dependent kinase 1 (CDK1) and CDK2, extracellular signal-regulated kinase (ERK), protein kinase A (PKA), and PKC alpha, with CDK1/2 serine 32 and ERK threonine 57 phosphorylations representing the two primary events seen in cells in cycle.	Threonine	206-215	cyclin dependent kinase 1	Homo sapiens	49-74
18926623-4	2009	5"-NIO reduced the activity of Cdc2/cyclin B complex through the inhibition of the PLK1 expression.	5'-nitroindirubinoxime	0-6	cyclin dependent kinase 1	Homo sapiens	31-35
19059218-4	2009	In this study, we demonstrate that 8-Cl-Ado-induced DNA damage activates G2/M phase checkpoint, which is associated with ATM-activated CHK1-CDC25C-CDC2 pathway joined by BRCA1-CHK1 branch in apoptosis-resistant human myelocytic leukemia K562 (p53-null) cells.	8-chloroadenosine	35-43	cyclin dependent kinase 1	Homo sapiens	140-144
19067706-13	2009	We further found that bexarotene activates p53 by phosphorylation at Ser15, which influences the binding of p53 to promoters for cell cycle arrest, induces p73 upregulation, and, in concordance, also modulates some p53/p73 downstream target genes, such as p21, Bax, survivin and cdc2.	Bexarotene	22-32	cyclin dependent kinase 1	Homo sapiens	279-283
19223768-2	2009	Cyclic AMP (cAMP)-mediated Protein Kinase A (PKA) activity sustains prophase arrest by inhibiting Cdk1.	Cyclic AMP	0-10	cyclin dependent kinase 1	Homo sapiens	98-102
19223768-2	2009	Cyclic AMP (cAMP)-mediated Protein Kinase A (PKA) activity sustains prophase arrest by inhibiting Cdk1.	Cyclic AMP	12-16	cyclin dependent kinase 1	Homo sapiens	98-102
19223768-4	2009	Cdc25 phosphatases can activate Cdks by removing inhibitory phosphates from Cdks.	Phosphates	60-70	cyclin dependent kinase 1	Homo sapiens	32-36
19223768-4	2009	Cdc25 phosphatases can activate Cdks by removing inhibitory phosphates from Cdks.	Phosphates	60-70	cyclin dependent kinase 1	Homo sapiens	76-80
19223503-8	2009	The combination of rapamycin and UCN-01 synergistically inhibited the DLBCL cell proliferation by inducing G1 arrest as well as apoptosis by suppressing the phosphorylation of p70S6K/p85S6K and CDC2 expression.	Sirolimus	19-28	cyclin dependent kinase 1	Homo sapiens	194-198
19223503-8	2009	The combination of rapamycin and UCN-01 synergistically inhibited the DLBCL cell proliferation by inducing G1 arrest as well as apoptosis by suppressing the phosphorylation of p70S6K/p85S6K and CDC2 expression.	7-hydroxystaurosporine	33-39	cyclin dependent kinase 1	Homo sapiens	194-198
19187565-6	2009	Inhibition of meiosis resumption by forskolin treatment prevented translocation of CDC2 to this ERES cluster.	Colforsin	36-45	cyclin dependent kinase 1	Homo sapiens	83-87
19187565-8	2009	After removal of forskolin from the culture media, the transient translocation of CDC2 to ERES was accompanied by a transient dispersion of P-GM130 into the ER suggesting a role for CDC2 in redistributing Golgi components that have collapsed into ERES further into the ER during meiosis.	Colforsin	17-26	cyclin dependent kinase 1	Homo sapiens	82-86
19038232-5	2009	Genistein stimulates p21(waf1/cip1) and cyclin B1 expression, phosphorylation/activation of ATM and Chk2 kinases, and Tyr15-phosphorylation/inactivation of Cdc2 (Cdk1) kinase, and these effects are attenuated by MEK/ERK inhibitors, while LY294002 also attenuates ERK and ATM phosphorylation.	Genistein	0-9	cyclin dependent kinase 1	Homo sapiens	156-160
19038232-5	2009	Genistein stimulates p21(waf1/cip1) and cyclin B1 expression, phosphorylation/activation of ATM and Chk2 kinases, and Tyr15-phosphorylation/inactivation of Cdc2 (Cdk1) kinase, and these effects are attenuated by MEK/ERK inhibitors, while LY294002 also attenuates ERK and ATM phosphorylation.	Genistein	0-9	cyclin dependent kinase 1	Homo sapiens	162-166
18586356-0	2009	Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1-5, GSK-3) inhibitors.	dipyrrolo- and furopyrrolopyrazinones	17-54	cyclin dependent kinase 1	Homo sapiens	132-139
18586356-0	2009	Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1-5, GSK-3) inhibitors.	tripentones	66-77	cyclin dependent kinase 1	Homo sapiens	132-139
19148545-4	2009	In addition, the dehydrocostuslactone-induced accumulation of cells at the G2/M phase transition interface resulted in a significant decrease in CDK1 together with cyclin A and cyclin B.	dehydrocostus lactone	17-37	cyclin dependent kinase 1	Homo sapiens	145-149
19148545-7	2009	Based on our findings, the mechanism by which dehydrocostuslactone causes cell cycle arrest is via CDK1 down-regulation, and its induction of apoptosis appears to be related to the activation of p53 and the release of cytochrome c.	dehydrocostus lactone	46-66	cyclin dependent kinase 1	Homo sapiens	99-103
19239702-0	2009	Prediction of paclitaxel sensitivity by CDK1 and CDK2 activity in human breast cancer cells.	Paclitaxel	14-24	cyclin dependent kinase 1	Homo sapiens	40-44
19208826-5	2009	Cdc-2, Cdc-25C, Cyclin-B1, and epidermal growth factor receptor were altered significantly by crocetin.	crocetin	94-102	cyclin dependent kinase 1	Homo sapiens	0-5
19148524-6	2009	The G1 phase arrest is associated with down-regulation of Cyclin D1/Cdk4 and Cyclin B1/Cdc2 activities in cells after treatment with KG-135.	kg-135	133-139	cyclin dependent kinase 1	Homo sapiens	87-91
19147767-6	2009	Decreased levels of cyclin-dependent kinases 2, 4, and 6, CDC2, and cyclins D1, D3, E, and A were observed, indicating an inhibitory effect of silibinin on cell cycle progression.	Silybin	143-152	cyclin dependent kinase 1	Homo sapiens	58-62
19322700-8	2009	G2-M arrest by oxypeucedanin was associated with decreased levels of cyclin A, cyclin B1, Cdc2, and pCdc2.	oxypeucadanin	15-28	cyclin dependent kinase 1	Homo sapiens	90-94
19239702-4	2009	We hypothesized that cyclin-dependent kinase (CDK) 1 activity and CDK2 activity in cancer cells, which reflect the activation state of the spindle assembly checkpoint and the growth state, respectively, predict sensitivity to paclitaxel.	Paclitaxel	226-236	cyclin dependent kinase 1	Homo sapiens	21-52
19239702-9	2009	Among the breast cancer xenograft tumors, however, tumors with significantly increased CDK1 specific activity after paclitaxel treatment were sensitive to paclitaxel in vivo, whereas tumors without such an increase were resistant to paclitaxel in vivo.	Paclitaxel	116-126	cyclin dependent kinase 1	Homo sapiens	87-91
19239702-9	2009	Among the breast cancer xenograft tumors, however, tumors with significantly increased CDK1 specific activity after paclitaxel treatment were sensitive to paclitaxel in vivo, whereas tumors without such an increase were resistant to paclitaxel in vivo.	Paclitaxel	155-165	cyclin dependent kinase 1	Homo sapiens	87-91
19239702-9	2009	Among the breast cancer xenograft tumors, however, tumors with significantly increased CDK1 specific activity after paclitaxel treatment were sensitive to paclitaxel in vivo, whereas tumors without such an increase were resistant to paclitaxel in vivo.	Paclitaxel	155-165	cyclin dependent kinase 1	Homo sapiens	87-91
19239702-11	2009	CONCLUSIONS: The change in CDK1 specific activity of xenograft tumors after paclitaxel treatment and the CDK2 specific activity before paclitaxel treatment are both associated with the drug sensitivity in vivo.	Paclitaxel	76-86	cyclin dependent kinase 1	Homo sapiens	27-31
19239702-11	2009	CONCLUSIONS: The change in CDK1 specific activity of xenograft tumors after paclitaxel treatment and the CDK2 specific activity before paclitaxel treatment are both associated with the drug sensitivity in vivo.	Paclitaxel	135-145	cyclin dependent kinase 1	Homo sapiens	27-31
19107353-4	2008	The rAAV encoding cdc2-siRNA (rAAV-EGFP-U6-cdc2-siRNA) was packed by calcium phosphate mediated co-transfection of the plasmid pAAV-MCS-EGFP-U6-cdc2-siRNA, p-RC and p-Helper into AAV-293 cells.	calcium phosphate	69-86	cyclin dependent kinase 1	Homo sapiens	18-22
19009557-7	2009	In addition, quercetin down-regulated the cyclin B1 and CDK1, essential components of G(2)/M cell cycle progression.	Quercetin	13-22	cyclin dependent kinase 1	Homo sapiens	56-60
19066455-2	2008	Quite early on, Laurent Meijer and his colleagues discovered roscovitine as a potent inhibitor of Cdk1 and the compound went into clinical trials (as CYC202 or Seliciclib) whose outcomes are awaited.	Roscovitine	61-72	cyclin dependent kinase 1	Homo sapiens	98-102
19669740-5	2009	Western blot revealed that surfactin induced accumulation of the tumor suppressor p53 and cyclin kinase inhibitor p21(waf1/cip1), and inhibited the activity of the G(2)-specific kinase, cyclin B1/p34(cdc2).	surfactin peptide	27-36	cyclin dependent kinase 1	Homo sapiens	200-204
19275612-3	2009	Immunoblot assay showed that chalcones significantly decreased the expression of cyclin Bl, cyclin A and Cdc2 protein, as well as increased the expression of p21 and p27 in a p53-independent manner, contributing to cell cycle arrest.	Chalcones	29-38	cyclin dependent kinase 1	Homo sapiens	105-109
19139124-11	2009	Sorafenib also induced cell cycle arrest, evident through increased levels of p15 and p27 and decreased levels of p21, cyclin A, cyclin B1, and cdc-2.	Sorafenib	0-9	cyclin dependent kinase 1	Homo sapiens	144-149
18977199-3	2008	Here we identify two threonine residues in the CAP-G subunit of condensin, threonines 308 and 332, that are targets of cdc2/cyclin B phosphorylation.	Threonine	21-30	cyclin dependent kinase 1	Homo sapiens	119-123
18977199-3	2008	Here we identify two threonine residues in the CAP-G subunit of condensin, threonines 308 and 332, that are targets of cdc2/cyclin B phosphorylation.	Threonine	75-85	cyclin dependent kinase 1	Homo sapiens	119-123
19107353-4	2008	The rAAV encoding cdc2-siRNA (rAAV-EGFP-U6-cdc2-siRNA) was packed by calcium phosphate mediated co-transfection of the plasmid pAAV-MCS-EGFP-U6-cdc2-siRNA, p-RC and p-Helper into AAV-293 cells.	calcium phosphate	69-86	cyclin dependent kinase 1	Homo sapiens	43-47
19107353-4	2008	The rAAV encoding cdc2-siRNA (rAAV-EGFP-U6-cdc2-siRNA) was packed by calcium phosphate mediated co-transfection of the plasmid pAAV-MCS-EGFP-U6-cdc2-siRNA, p-RC and p-Helper into AAV-293 cells.	calcium phosphate	69-86	cyclin dependent kinase 1	Homo sapiens	43-47
19107353-4	2008	The rAAV encoding cdc2-siRNA (rAAV-EGFP-U6-cdc2-siRNA) was packed by calcium phosphate mediated co-transfection of the plasmid pAAV-MCS-EGFP-U6-cdc2-siRNA, p-RC and p-Helper into AAV-293 cells.	paav	127-131	cyclin dependent kinase 1	Homo sapiens	18-22
19107353-4	2008	The rAAV encoding cdc2-siRNA (rAAV-EGFP-U6-cdc2-siRNA) was packed by calcium phosphate mediated co-transfection of the plasmid pAAV-MCS-EGFP-U6-cdc2-siRNA, p-RC and p-Helper into AAV-293 cells.	paav	127-131	cyclin dependent kinase 1	Homo sapiens	43-47
19107353-4	2008	The rAAV encoding cdc2-siRNA (rAAV-EGFP-U6-cdc2-siRNA) was packed by calcium phosphate mediated co-transfection of the plasmid pAAV-MCS-EGFP-U6-cdc2-siRNA, p-RC and p-Helper into AAV-293 cells.	paav	127-131	cyclin dependent kinase 1	Homo sapiens	43-47
19107353-5	2008	DNA sequencing proved the successful construction of U6-cdc2-siRNA in pAAV-MCS-EGFP.	paav-mcs	70-78	cyclin dependent kinase 1	Homo sapiens	56-60
18981479-3	2008	Here we show that RO3306 inhibition of cyclin-dependent protein kinase 1 (CDK1), the enzyme required to enter mitosis, induced differentiation of TS cells into TG cells.	RO 3306	18-24	cyclin dependent kinase 1	Homo sapiens	39-72
19138991-7	2008	Flavokawain A significantly reduced the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and caused cyclin B1 protein accumulation leading to CDK1 activation in T24 cells.	flavokawain A	0-13	cyclin dependent kinase 1	Homo sapiens	54-58
19138991-7	2008	Flavokawain A significantly reduced the expression of CDK1-inhibitory kinases, Myt1 and Wee1, and caused cyclin B1 protein accumulation leading to CDK1 activation in T24 cells.	flavokawain A	0-13	cyclin dependent kinase 1	Homo sapiens	147-151
19138991-9	2008	Consistently, flavokawain A also caused a pronounced CDK1 activation and G(2)-M arrest in p53 knockout but not in p53 wild-type HCT116 cells.	flavokawain A	14-27	cyclin dependent kinase 1	Homo sapiens	53-57
19074854-1	2008	Cdc25C is a dual-specificity phosphatase that is involved in induction of mitosis by removal of the inhibitory phosphates from cyclin-dependent kinase 1/cyclin B.	Phosphates	111-121	cyclin dependent kinase 1	Homo sapiens	127-152
19074855-8	2008	These cells were killed by bortezomib, albeit at higher pharmacologic concentrations, via mitotic catastrophe-a mitotic cell death associated with M-phase arrest, cyclin B1 accumulation, and increased CDC2/CDK1 activity.	Bortezomib	27-37	cyclin dependent kinase 1	Homo sapiens	201-205
19074855-8	2008	These cells were killed by bortezomib, albeit at higher pharmacologic concentrations, via mitotic catastrophe-a mitotic cell death associated with M-phase arrest, cyclin B1 accumulation, and increased CDC2/CDK1 activity.	Bortezomib	27-37	cyclin dependent kinase 1	Homo sapiens	206-210
18981479-3	2008	Here we show that RO3306 inhibition of cyclin-dependent protein kinase 1 (CDK1), the enzyme required to enter mitosis, induced differentiation of TS cells into TG cells.	RO 3306	18-24	cyclin dependent kinase 1	Homo sapiens	74-78
18981479-4	2008	In contrast, RO3306 induced abortive endoreduplication and apoptosis in embryonic stem cells, revealing that inactivation of CDK1 triggers endoreduplication only in cells programmed to differentiate into polyploid cells.	RO 3306	13-19	cyclin dependent kinase 1	Homo sapiens	125-129
18224451-5	2008	Genistein-mediated G2/M arrest was associated with a decrease in the protein levels of Cdk1, cyclinB1, and Cdc25C as determined by Western blot analysis.	Genistein	0-9	cyclin dependent kinase 1	Homo sapiens	87-91
18539383-5	2008	Calu-6 cells treated with 1, 3 or 5 microM ATO showed a G2 phase arrest of the cell cycle at 72 h. The G2 phase arrest was accompanied with the down-regulation of cdc2 protein.	Arsenic Trioxide	43-46	cyclin dependent kinase 1	Homo sapiens	163-167
18957166-0	2008	Oroxylin A induces G2/M phase cell-cycle arrest via inhibiting Cdk7-mediated expression of Cdc2/p34 in human gastric carcinoma BGC-823 cells.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	0-10	cyclin dependent kinase 1	Homo sapiens	91-95
18957166-4	2008	Western blot analysis demonstrated that oroxylin A-induced cell-cycle arrest in BGC-823 cells was associated with a significant decrease in cdc2/p34, cyclin B1 and cyclin A expression.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	40-50	cyclin dependent kinase 1	Homo sapiens	140-144
18957166-5	2008	In addition, oroxylin A-treated cells decreased the expression of Cdk7, which was responsible for the low expression of M phase promoting factor (cyclin B1/Cdc2).	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	13-23	cyclin dependent kinase 1	Homo sapiens	156-160
18957166-6	2008	The results suggested that oroxylin A induced G2/M phase cell-cycle arrest via inhibiting Cdk7-mediated expression of Cdc2/p34 in human gastric carcinoma BGC-823 cells.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	27-37	cyclin dependent kinase 1	Homo sapiens	118-122
18817634-5	2008	Furthermore, LGH00045 impaired the proliferation of tumor cells and increased cyclin-dependent kinase 1 inhibitory tyrosine phosphorylation.	Tyrosine	115-123	cyclin dependent kinase 1	Homo sapiens	78-103
18193228-0	2008	7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel synthetic compound induces lung carcinoma cell death associated with inhibiting ERK and CDC2 phosphorylation via a p53-independent pathway.	7-chloro-6-piperidin-1-ylquinoline-5,8-dione	0-45	cyclin dependent kinase 1	Homo sapiens	152-156
18193228-0	2008	7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel synthetic compound induces lung carcinoma cell death associated with inhibiting ERK and CDC2 phosphorylation via a p53-independent pathway.	Platinum	47-50	cyclin dependent kinase 1	Homo sapiens	152-156
18193228-14	2008	The mitosis-regulated protein levels of cyclin B1 and phospho-CDC2 at Thr14, Tyr15, and Thr161 were repressed by PT-262 in these cells.	Platinum	113-115	cyclin dependent kinase 1	Homo sapiens	62-66
19035289-7	2008	Interestingly, delta-tocotrienol also caused a marked reduction in the expression of G2/M regulatory proteins including cyclin B1 and CDK1.	tocotrienol, delta	15-32	cyclin dependent kinase 1	Homo sapiens	134-138
18723675-3	2008	Cells in which endogenous RPA2 was replaced by a mutant subunit lacking both Cdc2 sites had a significant defect in mitotic release into a 2N G(1) phase after exposure to bleomycin.	Bleomycin	171-180	cyclin dependent kinase 1	Homo sapiens	77-81
18813780-4	2008	PTX induced a dose- and time-dependent effect, with G2/M arrest, cyclines A, E and B1 accumulation and a marked modification in the status of Cdc2-cyclin B1 complex, the major player of the G2/M checkpoint.	Paclitaxel	0-3	cyclin dependent kinase 1	Homo sapiens	142-146
18813819-8	2008	Higher concentrations (24-30 microM) of piplartine modulated apoptosis-related protein expression by down-regulating cdc-2 expression and up-regulating PARP/procaspase-3 cleavage.	piplartine	40-50	cyclin dependent kinase 1	Homo sapiens	117-122
18501396-4	2008	Arsenite also increased activating cyclin dependent kinase 1 (CDK1) Thr(161) phosphorylation but decreased inhibitory Tyr15 phosphorylation.	arsenite	0-8	cyclin dependent kinase 1	Homo sapiens	35-60
18541420-7	2008	The protein expression of CDK1 related to the G2/M phase decreased markedly with daidzein treatment, whereas slight expression of cyclins A and B occurred.	daidzein	81-89	cyclin dependent kinase 1	Homo sapiens	26-30
18541420-8	2008	Daidzein treatment increased the expression of the CDK inhibitors p21(Cip1) and p57(Kip2), but not that of p27(Kip1).	daidzein	0-8	cyclin dependent kinase 1	Homo sapiens	51-54
18574241-4	2008	IRP2 Ser-157 is phosphorylated by Cdk1/cyclin B1 during G(2)/M and is dephosphorylated during mitotic exit by the phosphatase Cdc14A.	Serine	5-8	cyclin dependent kinase 1	Homo sapiens	34-38
18501396-4	2008	Arsenite also increased activating cyclin dependent kinase 1 (CDK1) Thr(161) phosphorylation but decreased inhibitory Tyr15 phosphorylation.	arsenite	0-8	cyclin dependent kinase 1	Homo sapiens	62-66
18501396-4	2008	Arsenite also increased activating cyclin dependent kinase 1 (CDK1) Thr(161) phosphorylation but decreased inhibitory Tyr15 phosphorylation.	Threonine	68-71	cyclin dependent kinase 1	Homo sapiens	62-66
18501396-7	2008	Inhibition of CDK1 with roscovitine in arsenite-treated mitotic cells inhibited spindle checkpoint maintenance as inferred from reduced BUBR1 phosphorylation, reduced cyclin B expression, and diminution of mitotic index.	Roscovitine	24-35	cyclin dependent kinase 1	Homo sapiens	14-18
18501396-7	2008	Inhibition of CDK1 with roscovitine in arsenite-treated mitotic cells inhibited spindle checkpoint maintenance as inferred from reduced BUBR1 phosphorylation, reduced cyclin B expression, and diminution of mitotic index.	arsenite	39-47	cyclin dependent kinase 1	Homo sapiens	14-18
18501396-8	2008	Roscovitine also reduced BCL-2 Ser70 phosphorylation and protected against apoptosis, suggesting mitotic arrest caused by hyperactivation of CDK1 directly or indirectly leads to BCL-2 phosphorylation and apoptosis.	Roscovitine	0-11	cyclin dependent kinase 1	Homo sapiens	141-145
18639462-0	2008	Nitrogen-containing flavonoid analogues as CDK1/cyclin B inhibitors: synthesis, SAR analysis, and biological activity.	Nitrogen	0-8	cyclin dependent kinase 1	Homo sapiens	43-47
18408765-2	2008	Here, we demonstrate that cyclin-dependent kinase 1 (CDK1) specifically phosphorylates FOXO1 at serine 249 (S249) in vitro and in vivo.	Serine	96-102	cyclin dependent kinase 1	Homo sapiens	26-51
18408765-2	2008	Here, we demonstrate that cyclin-dependent kinase 1 (CDK1) specifically phosphorylates FOXO1 at serine 249 (S249) in vitro and in vivo.	Serine	96-102	cyclin dependent kinase 1	Homo sapiens	53-57
18639462-0	2008	Nitrogen-containing flavonoid analogues as CDK1/cyclin B inhibitors: synthesis, SAR analysis, and biological activity.	Flavonoids	20-29	cyclin dependent kinase 1	Homo sapiens	43-47
18639462-2	2008	The results showed that C-8 nitrogen-containing baicalein analogues 3a-3f exhibited potent CDK1/Cyclin B inhibitory activities.	Nitrogen	28-36	cyclin dependent kinase 1	Homo sapiens	91-95
18639462-2	2008	The results showed that C-8 nitrogen-containing baicalein analogues 3a-3f exhibited potent CDK1/Cyclin B inhibitory activities.	baicalein	48-57	cyclin dependent kinase 1	Homo sapiens	91-95
17981370-0	2008	Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: synthesis, biological evaluation and molecular modeling studies.	9-oxo-thiazolo(5,4-f)quinazoline-2-carbonitrile	6-53	cyclin dependent kinase 1	Homo sapiens	74-99
18374481-3	2008	Galangin induced an arrest of cells in G0-G1phase of cell cycle and a decrease in pRb, cdk4, cdk1, cycline B levels; moreover, it was able to induce a monocytic differentiation of leukemic Bcr-Abl+ cells.	galangin	0-8	cyclin dependent kinase 1	Homo sapiens	93-97
18525318-8	2008	The results showed that TM208 decreased the expression of protein kinase C alpha, phospho-extracellular signal-regulated kinase-1/2, phospho-p38, cyclin B1, cell division cycle 2 (cdc2), and phospho-cdc2 (Thr161) and increased the expression of phospho-cdc2 (Tyr15).	4-methylpiperazine-1-carbodithioc acid 3-cyano-3,3-diphenylpropyl ester hydrochloride	24-29	cyclin dependent kinase 1	Homo sapiens	157-178
18525318-8	2008	The results showed that TM208 decreased the expression of protein kinase C alpha, phospho-extracellular signal-regulated kinase-1/2, phospho-p38, cyclin B1, cell division cycle 2 (cdc2), and phospho-cdc2 (Thr161) and increased the expression of phospho-cdc2 (Tyr15).	4-methylpiperazine-1-carbodithioc acid 3-cyano-3,3-diphenylpropyl ester hydrochloride	24-29	cyclin dependent kinase 1	Homo sapiens	180-184
18525318-8	2008	The results showed that TM208 decreased the expression of protein kinase C alpha, phospho-extracellular signal-regulated kinase-1/2, phospho-p38, cyclin B1, cell division cycle 2 (cdc2), and phospho-cdc2 (Thr161) and increased the expression of phospho-cdc2 (Tyr15).	4-methylpiperazine-1-carbodithioc acid 3-cyano-3,3-diphenylpropyl ester hydrochloride	24-29	cyclin dependent kinase 1	Homo sapiens	199-203
18525318-8	2008	The results showed that TM208 decreased the expression of protein kinase C alpha, phospho-extracellular signal-regulated kinase-1/2, phospho-p38, cyclin B1, cell division cycle 2 (cdc2), and phospho-cdc2 (Thr161) and increased the expression of phospho-cdc2 (Tyr15).	4-methylpiperazine-1-carbodithioc acid 3-cyano-3,3-diphenylpropyl ester hydrochloride	24-29	cyclin dependent kinase 1	Homo sapiens	199-203
17981370-1	2008	Continuous efforts in microwave-assisted synthesis and the structure-activity relationships" (SARs) studies of novel modified 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitriles, allowed identification of new amidine and imidate derivatives as potent and dual CDK1/GSK-3 inhibitors.	Amidines	206-213	cyclin dependent kinase 1	Homo sapiens	257-261
18571148-3	2008	Cell cycle analysis showed that the depolymerization of actin with PTX-2 induces G2/M phase arrest at 12 h and endoreduplication at 24 h. Analysis of the cell cycle regulatory proteins demonstrated that PTX-2 increases phosphorylation of cdc25c and decreases the protein levels of cdc2 and cyclin B1.	pectenotoxin 2	67-72	cyclin dependent kinase 1	Homo sapiens	238-242
18571148-3	2008	Cell cycle analysis showed that the depolymerization of actin with PTX-2 induces G2/M phase arrest at 12 h and endoreduplication at 24 h. Analysis of the cell cycle regulatory proteins demonstrated that PTX-2 increases phosphorylation of cdc25c and decreases the protein levels of cdc2 and cyclin B1.	pectenotoxin 2	203-208	cyclin dependent kinase 1	Homo sapiens	238-242
17981370-0	2008	Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: synthesis, biological evaluation and molecular modeling studies.	9-oxo-thiazolo(5,4-f)quinazoline-2-carbonitrile	6-53	cyclin dependent kinase 1	Homo sapiens	101-105
17981370-1	2008	Continuous efforts in microwave-assisted synthesis and the structure-activity relationships" (SARs) studies of novel modified 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitriles, allowed identification of new amidine and imidate derivatives as potent and dual CDK1/GSK-3 inhibitors.	9-oxo-thiazolo(5,4-f)quinazoline-2-carbonitrile	126-174	cyclin dependent kinase 1	Homo sapiens	257-261
18374381-3	2008	Treatment of cancer cells with KTA to trigger G2/M phase arrest was associated with increased p21/WAF1 levels and reduced amounts of cyclin A, cyclin B1, cdc2 and cdc25C.	kotomolide A	31-34	cyclin dependent kinase 1	Homo sapiens	154-158
18433847-12	2008	Higher concentration of stilbene 5c arrests cell cycle in G(2)/M phase, which is supported by dephosphorylation of Cdc2 and Cdc25C, and transiently elevation of spindle checkpoint BubR1.	Stilbenes	24-32	cyclin dependent kinase 1	Homo sapiens	115-119
18247328-2	2008	In this article, we demonstrated that lithium arrested hepatocellular carcinoma cell SMMC-7721 at G2/M checkpoint by inducing the phosphorylation of cdc2 (Tyr-15).	Lithium	38-45	cyclin dependent kinase 1	Homo sapiens	149-153
18247328-2	2008	In this article, we demonstrated that lithium arrested hepatocellular carcinoma cell SMMC-7721 at G2/M checkpoint by inducing the phosphorylation of cdc2 (Tyr-15).	smmc	85-89	cyclin dependent kinase 1	Homo sapiens	149-153
18247328-2	2008	In this article, we demonstrated that lithium arrested hepatocellular carcinoma cell SMMC-7721 at G2/M checkpoint by inducing the phosphorylation of cdc2 (Tyr-15).	Tyrosine	155-158	cyclin dependent kinase 1	Homo sapiens	149-153
18247328-5	2008	The lithium-induced phosphorylation of cdc2 and G2/M arrest was abrogated largely by SB218078, a potent Chk1 inhibitor, as well as by Chk1 siRNA or the over-expression of kinase dead Chk1.	Lithium	4-11	cyclin dependent kinase 1	Homo sapiens	39-43
18247328-5	2008	The lithium-induced phosphorylation of cdc2 and G2/M arrest was abrogated largely by SB218078, a potent Chk1 inhibitor, as well as by Chk1 siRNA or the over-expression of kinase dead Chk1.	SB 218078	85-93	cyclin dependent kinase 1	Homo sapiens	39-43
18247328-9	2008	Moreover, caffeine, a known ATM/ATR kinase inhibitor, relieved the phosphorylation of cdc2 (Tyr-15) by hydroxyurea, but not that by lithium.	Caffeine	10-18	cyclin dependent kinase 1	Homo sapiens	86-90
18247328-9	2008	Moreover, caffeine, a known ATM/ATR kinase inhibitor, relieved the phosphorylation of cdc2 (Tyr-15) by hydroxyurea, but not that by lithium.	Tyrosine	92-95	cyclin dependent kinase 1	Homo sapiens	86-90
18468578-4	2008	In addition, magnolol treatment strongly induced p27KIP1 expression, and down-regulated expression of cyclin-dependent kinases (CDKs) and cyclins.	magnolol	13-21	cyclin dependent kinase 1	Homo sapiens	128-132
18524952-4	2008	Although the precise roles of specific MCM phosphorylation events are poorly characterized, we now demonstrate that CDK1 phosphorylates MCM3 at Ser-112, Ser-611, and Thr-719.	Serine	144-147	cyclin dependent kinase 1	Homo sapiens	116-120
18524952-4	2008	Although the precise roles of specific MCM phosphorylation events are poorly characterized, we now demonstrate that CDK1 phosphorylates MCM3 at Ser-112, Ser-611, and Thr-719.	Serine	153-156	cyclin dependent kinase 1	Homo sapiens	116-120
18524952-4	2008	Although the precise roles of specific MCM phosphorylation events are poorly characterized, we now demonstrate that CDK1 phosphorylates MCM3 at Ser-112, Ser-611, and Thr-719.	Threonine	166-169	cyclin dependent kinase 1	Homo sapiens	116-120
18524952-5	2008	In vivo, CDK1-dependent phosphorylation of Ser-112 triggers the assembly of MCM3 with the remaining MCM subunits and subsequent chromatin loading of MCMs.	Serine	43-46	cyclin dependent kinase 1	Homo sapiens	9-13
18479465-3	2008	This site is equivalent to tyrosine 15 of cyclin dependent kinase 1, which undergoes inhibitory phosphorylation by WEE1 and MYT1; however, the kinases that phosphorylate cyclin dependent kinase 4 on tyrosine 17 are still unknown.	Tyrosine	27-35	cyclin dependent kinase 1	Homo sapiens	42-67
18479465-3	2008	This site is equivalent to tyrosine 15 of cyclin dependent kinase 1, which undergoes inhibitory phosphorylation by WEE1 and MYT1; however, the kinases that phosphorylate cyclin dependent kinase 4 on tyrosine 17 are still unknown.	Tyrosine	199-207	cyclin dependent kinase 1	Homo sapiens	42-67
18511169-5	2008	In addition, KTA-mediated G2/M phase arrest also was associated with the decrease in the amounts of cyclinB1, cyclinA, Cdc2 and Cdc25C and increase in the phosphorylation of Chk2, Cdc25C and Cdc2.	kotomolide A	13-16	cyclin dependent kinase 1	Homo sapiens	119-123
18511169-5	2008	In addition, KTA-mediated G2/M phase arrest also was associated with the decrease in the amounts of cyclinB1, cyclinA, Cdc2 and Cdc25C and increase in the phosphorylation of Chk2, Cdc25C and Cdc2.	kotomolide A	13-16	cyclin dependent kinase 1	Homo sapiens	128-132
18490441-0	2008	Phosphorylation of threonine 61 by cyclin a/Cdk1 triggers degradation of stem-loop binding protein at the end of S phase.	Threonine	19-28	cyclin dependent kinase 1	Homo sapiens	44-48
18494457-3	2008	The series of 4-(phenylaminomethylene)isoquinoline-1,3(2H,4H)-dione derivatives reported here represents a novel class of potent inhibitors that selectively inhibit CDK4 over CDK2 and CDK1 activities.	SCHEMBL3572467	14-67	cyclin dependent kinase 1	Homo sapiens	184-188
17869387-6	2008	HT-29 cells treated with doxorubicin and then target compounds demonstrate an active Cdc2/cyclin B complex, inhibition of the doxorubicin-induced phosphorylation of tyrosine 15 of Cdc2 and abrogation of the G2 checkpoint.	Doxorubicin	25-36	cyclin dependent kinase 1	Homo sapiens	85-89
17869387-6	2008	HT-29 cells treated with doxorubicin and then target compounds demonstrate an active Cdc2/cyclin B complex, inhibition of the doxorubicin-induced phosphorylation of tyrosine 15 of Cdc2 and abrogation of the G2 checkpoint.	Doxorubicin	25-36	cyclin dependent kinase 1	Homo sapiens	180-184
17869387-6	2008	HT-29 cells treated with doxorubicin and then target compounds demonstrate an active Cdc2/cyclin B complex, inhibition of the doxorubicin-induced phosphorylation of tyrosine 15 of Cdc2 and abrogation of the G2 checkpoint.	Doxorubicin	126-137	cyclin dependent kinase 1	Homo sapiens	85-89
17869387-6	2008	HT-29 cells treated with doxorubicin and then target compounds demonstrate an active Cdc2/cyclin B complex, inhibition of the doxorubicin-induced phosphorylation of tyrosine 15 of Cdc2 and abrogation of the G2 checkpoint.	Doxorubicin	126-137	cyclin dependent kinase 1	Homo sapiens	180-184
17869387-6	2008	HT-29 cells treated with doxorubicin and then target compounds demonstrate an active Cdc2/cyclin B complex, inhibition of the doxorubicin-induced phosphorylation of tyrosine 15 of Cdc2 and abrogation of the G2 checkpoint.	Tyrosine	165-173	cyclin dependent kinase 1	Homo sapiens	85-89
17869387-6	2008	HT-29 cells treated with doxorubicin and then target compounds demonstrate an active Cdc2/cyclin B complex, inhibition of the doxorubicin-induced phosphorylation of tyrosine 15 of Cdc2 and abrogation of the G2 checkpoint.	Tyrosine	165-173	cyclin dependent kinase 1	Homo sapiens	180-184
18446845-6	2008	ESS-mediated G2/M arrest was found to be associated with up-regulation of cyclin A, Cdc2, tumor suppressor p53 and cyclin dependent kinase (Cdk) inhibitor p21(WAF1/CIP1), whereas the expressions of other G2/M regulatory proteins, including cyclin B1 and Cdk2, were down-regulated compared with the control.	ESS	0-3	cyclin dependent kinase 1	Homo sapiens	84-88
18418077-4	2008	Using live cell imaging and various approaches that uncoupled mitotic events, we show that apoptosis was induced by both prolonged nocodazole treatment as well as by inhibition of CDK1 activity after a transient nocodazole block.	Nocodazole	212-222	cyclin dependent kinase 1	Homo sapiens	180-184
18577252-7	2008	Cell cycle arrest by LA was correlated with dose-dependent down regulation of Rb phosphorylation, likely via suppression of E2F-dependent cell cycle progression with an accompanying inhibition of cyclin E/cdk2 and cyclin B1/cdk1 levels.	Rubidium	78-80	cyclin dependent kinase 1	Homo sapiens	224-228
18418077-6	2008	The massive apoptosis triggered by nocodazole treatment requires the continuous activation of cyclin B1-CDK1 and is antagonized by premature mitotic slippage.	Nocodazole	35-45	cyclin dependent kinase 1	Homo sapiens	104-108
18425329-3	2008	Estradiol induces cyclin D1 and CDK1 proteins in Ki-67 positive proliferating cells, whereas survivin is up-regulated in both Ki-67 positive proliferative outer layer of cells and around the necrotic zone in non-proliferating cells.	Estradiol	0-9	cyclin dependent kinase 1	Homo sapiens	32-36
18071308-5	2008	Activated CDC2 phosphorylates Bad at serine-128 and facilitates its translocation to the mitochondria, where Bad triggers apoptosis.	Serine	37-43	cyclin dependent kinase 1	Homo sapiens	10-14
18071308-6	2008	In contrast, PKC412 inactivates CDC2 by inducing serine-216 phosphorylation and subsequent cytoplasmic sequestration of CDC25c in THP-1 and U937 cells.	Serine	49-55	cyclin dependent kinase 1	Homo sapiens	32-36
18425329-5	2008	Consistent with its antiproliferative effect, we observed that OH-Tam induces an important decrease in the proportion of proliferating cells, positive for Ki-67, cyclin D1 and CDK1.	oh-tam	63-69	cyclin dependent kinase 1	Homo sapiens	176-180
18337751-9	2008	Inactivation of eEF2K by cdc2 may serve to keep eEF2 active during mitosis (where calcium levels rise) and thereby permit protein synthesis to proceed in mitotic cells.	Calcium	82-89	cyclin dependent kinase 1	Homo sapiens	25-29
18272572-5	2008	In uninfected cells, the cdc25C phosphatase activates cdc2 by removing two inhibitory phosphates.	Phosphates	86-96	cyclin dependent kinase 1	Homo sapiens	25-29
18505930-6	2008	Interestingly, treatment of TLS-ERG-expressing L-G cells with 5-aza-2"-deoxycytidine (Decitabine) or trichostatin A resulted in down-regulation of Cdk1 and induction of terminal differentiation.	Decitabine	62-84	cyclin dependent kinase 1	Homo sapiens	147-151
18505930-6	2008	Interestingly, treatment of TLS-ERG-expressing L-G cells with 5-aza-2"-deoxycytidine (Decitabine) or trichostatin A resulted in down-regulation of Cdk1 and induction of terminal differentiation.	Decitabine	86-96	cyclin dependent kinase 1	Homo sapiens	147-151
18505930-6	2008	Interestingly, treatment of TLS-ERG-expressing L-G cells with 5-aza-2"-deoxycytidine (Decitabine) or trichostatin A resulted in down-regulation of Cdk1 and induction of terminal differentiation.	trichostatin A	101-115	cyclin dependent kinase 1	Homo sapiens	147-151
18413795-1	2008	AG-012986 is a multitargeted cyclin-dependent kinase (CDK) inhibitor active against CDK1, CDK2, CDK4/6, CDK5, and CDK9, with selectivity over a diverse panel of non-CDK kinases.	AG-012986	0-9	cyclin dependent kinase 1	Homo sapiens	84-88
18457570-0	2008	Effect of roscovitine, a selective cyclin B-dependent kinase 1 inhibitor, on assembly of the nucleolus in mitosis.	Roscovitine	10-21	cyclin dependent kinase 1	Homo sapiens	35-62
18457570-3	2008	In the present work, we show for the first time that selective inhibition of cyclin B-dependent kinase 1 (CDK1) by roscovitine induces premature assembly of the nucleolus in mammalian cells in metaphase.	Roscovitine	115-126	cyclin dependent kinase 1	Homo sapiens	77-104
18457570-3	2008	In the present work, we show for the first time that selective inhibition of cyclin B-dependent kinase 1 (CDK1) by roscovitine induces premature assembly of the nucleolus in mammalian cells in metaphase.	Roscovitine	115-126	cyclin dependent kinase 1	Homo sapiens	106-110
18353638-2	2008	Potent inhibitors against CDK1 and CDK2 were obtained by introduction of 1lambda(6)-isothiazolidine-1,1-dioxide at 5-position of indazole.	1lambda(6)-isothiazolidine-1,1-dioxide	73-111	cyclin dependent kinase 1	Homo sapiens	26-30
18353638-2	2008	Potent inhibitors against CDK1 and CDK2 were obtained by introduction of 1lambda(6)-isothiazolidine-1,1-dioxide at 5-position of indazole.	Indazoles	129-137	cyclin dependent kinase 1	Homo sapiens	26-30
18334118-9	2008	In addition, the proportion of SH-SY5Y cells at G1 phase was significantly increased with an apparent G1 phase arrest when treated with ISA (100, 200, 400 micromol/L) for 48 h. In the progress of cell cycle arrest induced by ISA, phosphorylated ERK and CDK1 expression were down-regulated (P&lt;0.05).	Isatin	136-139	cyclin dependent kinase 1	Homo sapiens	253-257
18311658-2	2008	The antitumor activity of terameprocol is based on the selective inhibition of specificity protein 1 (Sp1)-regulated proteins, including cyclin-dependent kinase 1, survivin and VEGF.	terameprocol	26-38	cyclin dependent kinase 1	Homo sapiens	137-162
19325754-8	2008	It was shown that the anti-proliferative effects of the xanthones were associated with cell-cycle arrest by affecting the expression of cyclins, cdc2, and p27; G1 arrest by alpha-mangostin and beta-Mangostin, and S arrest by gamma-mangostin.	Xanthones	56-65	cyclin dependent kinase 1	Homo sapiens	145-149
18334118-9	2008	In addition, the proportion of SH-SY5Y cells at G1 phase was significantly increased with an apparent G1 phase arrest when treated with ISA (100, 200, 400 micromol/L) for 48 h. In the progress of cell cycle arrest induced by ISA, phosphorylated ERK and CDK1 expression were down-regulated (P&lt;0.05).	Isatin	225-228	cyclin dependent kinase 1	Homo sapiens	253-257
18232654-0	2008	Pyrrolo[2,3-a]carbazoles as potential cyclin dependent kinase 1 (CDK1) Inhibitors.	pyrrolo[2,3-a]carbazoles	0-24	cyclin dependent kinase 1	Homo sapiens	38-63
18232654-0	2008	Pyrrolo[2,3-a]carbazoles as potential cyclin dependent kinase 1 (CDK1) Inhibitors.	pyrrolo[2,3-a]carbazoles	0-24	cyclin dependent kinase 1	Homo sapiens	65-69
18232654-2	2008	Pyrrolo[2,3- a]carbazole derivatives were synthesized, and their effects on CDK1/cyclinB activity were evaluated.	pyrrolo[2,3- a]carbazole	0-24	cyclin dependent kinase 1	Homo sapiens	76-80
18232654-4	2008	Using a computational model for CDK1-1e, binding we have observed that 1e exhibited two likely binding modes in the ATP-binding cleft that involve interactions with Lys130, Thr14, and Asp146 of the enzyme.	Adenosine Triphosphate	116-119	cyclin dependent kinase 1	Homo sapiens	32-36
18234856-2	2008	Cdk1 was engineered to accept an ATP analog that allows it to uniquely label its substrates with a bio-orthogonal phosphate analog tag.	Adenosine Triphosphate	33-36	cyclin dependent kinase 1	Homo sapiens	0-4
18250300-3	2008	During mitosis, Cdk1 phosphorylates Hbo1 on Thr-85/88, creating a docking site for Plk1 to be recruited.	Threonine	44-47	cyclin dependent kinase 1	Homo sapiens	16-20
18234856-2	2008	Cdk1 was engineered to accept an ATP analog that allows it to uniquely label its substrates with a bio-orthogonal phosphate analog tag.	Phosphates	114-123	cyclin dependent kinase 1	Homo sapiens	0-4
17420990-2	2008	In evaluating the mechanisms by which retinoic acid (RA) or nerve growth factor (NGF) decrease cell number in MYCN amplified NB cells, we have identified a number of proteins whose expression either decreases (E2F, CDC2, CDK6, cyclin dependent kinase activity) or increases (p27) in association with a decrease in MYCN expression.	Tretinoin	38-51	cyclin dependent kinase 1	Homo sapiens	215-219
17653574-15	2008	CONCLUSION: Bendamustine induces ATM-Chk2-Cdc2-mediated G2 arrest and p53 mediated apoptosis.	Bendamustine Hydrochloride	12-24	cyclin dependent kinase 1	Homo sapiens	42-46
18281518-7	2008	CHM-1-induced cell death, activation of Cdc2 kinase activity, and elevation of MPM2 phosphoepitopes were profoundly attenuated by roscovitine, a specific cyclin-dependent kinase inhibitor.	Roscovitine	130-141	cyclin dependent kinase 1	Homo sapiens	40-44
17942543-4	2008	To examine the role of cyclin-dependent kinases (cdks) in the establishment of this site, we used roscovitine, a specific inhibitor of cdk1, cdk2, cdk7, and cdk9, that alters processing of viral IE transcripts and inhibits expression of viral early genes.	Roscovitine	98-109	cyclin dependent kinase 1	Homo sapiens	49-53
18256527-4	2008	The JNK-specific inhibitor SP600125 blocked mitotic entry, as shown by its ability to prevent CDK1 dephosphorylation and cyclin A degradation.	pyrazolanthrone	27-35	cyclin dependent kinase 1	Homo sapiens	94-98
17942543-4	2008	To examine the role of cyclin-dependent kinases (cdks) in the establishment of this site, we used roscovitine, a specific inhibitor of cdk1, cdk2, cdk7, and cdk9, that alters processing of viral IE transcripts and inhibits expression of viral early genes.	Roscovitine	98-109	cyclin dependent kinase 1	Homo sapiens	135-139
20016737-5	2008	Of the G2/M-phase related proteins, kaempferol down-regulated CDK1 and cyclin A and B in cells exposed to kaempferol.	kaempferol	36-46	cyclin dependent kinase 1	Homo sapiens	62-66
20016737-5	2008	Of the G2/M-phase related proteins, kaempferol down-regulated CDK1 and cyclin A and B in cells exposed to kaempferol.	kaempferol	106-116	cyclin dependent kinase 1	Homo sapiens	62-66
18348409-5	2007	Western blotting was employed to detect cyclin B 1 and Cdc2 proteins in extracts from irradiated or non-irradiated cells of MCF-7/ADR, HT-29 and MCF-7 treated with tetrandrine at various concentrations.	tetrandrine	164-175	cyclin dependent kinase 1	Homo sapiens	55-59
17976513-4	2007	THIF treatment also led to an inhibition of cdc2, which was accompanied by the phosphorylation of both p53 (Ser15) and Chk1 (Ser296) and the de-activation of cdc25C phosphatase.	orobol	0-4	cyclin dependent kinase 1	Homo sapiens	44-48
17599054-4	2007	We present the first investigation of the therapeutic potential of CDK inhibitors, using the guanine-based CDK inhibitor NU2058 (CDK2 IC(50)=17 microM, CDK1 IC(50)=26 microM), in comparison with the antiandrogen bicalutamide (Casodex) in AIPC cells.	NU2058	121-127	cyclin dependent kinase 1	Homo sapiens	152-156
18089794-6	2007	Our results show that p38 is activated in response to hydroxyurea treatment and collaborates with Chk1 to prevent mitotic entry in non-transformed cell lines by maintaining cyclin B1/Cdk1 complexes inactive.	Hydroxyurea	54-65	cyclin dependent kinase 1	Homo sapiens	183-187
17905420-1	2007	OBJECTIVES: Terameprocol (M4N, EM-1421) is a novel transcription inhibitor that selectively interferes with HPV viral genes E6/E7 with Sp1-dependent promoters, and induces apoptosis by inactivation of the CDC2/cyclin B complex (maturation promoting factor) and production and phosphorylation of survivin.	terameprocol	12-24	cyclin dependent kinase 1	Homo sapiens	205-209
17905420-1	2007	OBJECTIVES: Terameprocol (M4N, EM-1421) is a novel transcription inhibitor that selectively interferes with HPV viral genes E6/E7 with Sp1-dependent promoters, and induces apoptosis by inactivation of the CDC2/cyclin B complex (maturation promoting factor) and production and phosphorylation of survivin.	terameprocol	26-29	cyclin dependent kinase 1	Homo sapiens	205-209
17905420-1	2007	OBJECTIVES: Terameprocol (M4N, EM-1421) is a novel transcription inhibitor that selectively interferes with HPV viral genes E6/E7 with Sp1-dependent promoters, and induces apoptosis by inactivation of the CDC2/cyclin B complex (maturation promoting factor) and production and phosphorylation of survivin.	terameprocol	31-38	cyclin dependent kinase 1	Homo sapiens	205-209
17619824-11	2007	Coincident with G2M arrest, phosphorylation of CDC2 on Tyr-15 was significantly elevated, which could be explained by the increase of Wee1 and decrease of CDC25C.	Tyrosine	55-58	cyclin dependent kinase 1	Homo sapiens	47-51
17960875-6	2007	In addition, we demonstrated that cdc2, which is known to phosphorylate HMGA1 proteins, could induce the phosphorylation of HMGA1 proteins at the same Ser/Thr sites.	Serine	151-154	cyclin dependent kinase 1	Homo sapiens	34-38
17960875-6	2007	In addition, we demonstrated that cdc2, which is known to phosphorylate HMGA1 proteins, could induce the phosphorylation of HMGA1 proteins at the same Ser/Thr sites.	Threonine	155-158	cyclin dependent kinase 1	Homo sapiens	34-38
17960875-7	2007	The two kinases, however, exhibited different site preferences for the phosphorylation: The preference for HIPK2 phosphorylation followed the order of Thr-77 &gt; Thr-52 &gt; Ser-35, whereas the order for cdc2 phosphorylation was Thr-52 &gt; Thr-77 &gt; Ser-35.	Threonine	151-154	cyclin dependent kinase 1	Homo sapiens	205-209
17960875-7	2007	The two kinases, however, exhibited different site preferences for the phosphorylation: The preference for HIPK2 phosphorylation followed the order of Thr-77 &gt; Thr-52 &gt; Ser-35, whereas the order for cdc2 phosphorylation was Thr-52 &gt; Thr-77 &gt; Ser-35.	Threonine	163-166	cyclin dependent kinase 1	Homo sapiens	205-209
17960875-7	2007	The two kinases, however, exhibited different site preferences for the phosphorylation: The preference for HIPK2 phosphorylation followed the order of Thr-77 &gt; Thr-52 &gt; Ser-35, whereas the order for cdc2 phosphorylation was Thr-52 &gt; Thr-77 &gt; Ser-35.	Threonine	163-166	cyclin dependent kinase 1	Homo sapiens	205-209
17960875-7	2007	The two kinases, however, exhibited different site preferences for the phosphorylation: The preference for HIPK2 phosphorylation followed the order of Thr-77 &gt; Thr-52 &gt; Ser-35, whereas the order for cdc2 phosphorylation was Thr-52 &gt; Thr-77 &gt; Ser-35.	Threonine	163-166	cyclin dependent kinase 1	Homo sapiens	205-209
17525741-0	2007	Inhibition of Hsp90 function by ansamycins causes downregulation of cdc2 and cdc25c and G(2)/M arrest in glioblastoma cell lines.	Lactams, Macrocyclic	32-42	cyclin dependent kinase 1	Homo sapiens	68-72
17888403-3	2007	The stress kinase p38 MAPK is activated in these cytosols and COPII loading can be rescued by depletion of p38 MAPK alpha or by the p38 MAPK inhibitor (SB203580) but not by inhibition/depletion of cdc2.	SB 203580	152-160	cyclin dependent kinase 1	Homo sapiens	197-201
18088187-9	2007	The pathway of Chk1 phosphorylation --&gt; Cdc25A degradation --&gt; inhibition of cyclin B1/Cdk1 activity --&gt; G2 arrest is accordingly resistant to staurosporine and UCN-01 in p53+/+ cells.	7-hydroxystaurosporine	170-176	cyclin dependent kinase 1	Homo sapiens	93-97
18088464-6	2007	The p21, survivin, cdc2 and Wee1Hu genes may be related to the differentiation and/or apoptosis of NB4 cells induced by As2O3.	Arsenic Trioxide	120-125	cyclin dependent kinase 1	Homo sapiens	19-23
18088464-7	2007	It is concluded that p21, survivin, cdc2 and Wee1Hu may play an important role in the mechanism underling arsenic trioxide-mediated NB4 cell apoptosis.	Arsenic Trioxide	106-122	cyclin dependent kinase 1	Homo sapiens	36-40
18025303-2	2007	Cdk1 inhibition by roscovitine is known to induce premature mitotic exit, whereas inhibition of the APC/C-dependent degradation of cyclin B1 by MG132 induces mitotic arrest.	Roscovitine	19-30	cyclin dependent kinase 1	Homo sapiens	0-4
17525741-4	2007	The protein levels of cell division cycle 2 (cdc2) kinase and cell division cycle 25c (cdc25c) were downregulated upon GA and 17-AAG treatment and cdc2 kinase activity was inhibited.	geldanamycin	119-121	cyclin dependent kinase 1	Homo sapiens	22-43
17525741-4	2007	The protein levels of cell division cycle 2 (cdc2) kinase and cell division cycle 25c (cdc25c) were downregulated upon GA and 17-AAG treatment and cdc2 kinase activity was inhibited.	geldanamycin	119-121	cyclin dependent kinase 1	Homo sapiens	45-49
17525741-4	2007	The protein levels of cell division cycle 2 (cdc2) kinase and cell division cycle 25c (cdc25c) were downregulated upon GA and 17-AAG treatment and cdc2 kinase activity was inhibited.	geldanamycin	119-121	cyclin dependent kinase 1	Homo sapiens	87-91
17525741-4	2007	The protein levels of cell division cycle 2 (cdc2) kinase and cell division cycle 25c (cdc25c) were downregulated upon GA and 17-AAG treatment and cdc2 kinase activity was inhibited.	tanespimycin	126-132	cyclin dependent kinase 1	Homo sapiens	22-43
17525741-4	2007	The protein levels of cell division cycle 2 (cdc2) kinase and cell division cycle 25c (cdc25c) were downregulated upon GA and 17-AAG treatment and cdc2 kinase activity was inhibited.	tanespimycin	126-132	cyclin dependent kinase 1	Homo sapiens	45-49
17525741-4	2007	The protein levels of cell division cycle 2 (cdc2) kinase and cell division cycle 25c (cdc25c) were downregulated upon GA and 17-AAG treatment and cdc2 kinase activity was inhibited.	tanespimycin	126-132	cyclin dependent kinase 1	Homo sapiens	87-91
17525741-7	2007	The association of cdc2 and cdc25c with p50(cdc37), an Hsp90 co-chaperone, decreased, but the interaction of cdc2 and cdc25c with the Hsp70 co-chaperone increased after ansamycin treatment.	Rifabutin	169-178	cyclin dependent kinase 1	Homo sapiens	19-23
17525741-7	2007	The association of cdc2 and cdc25c with p50(cdc37), an Hsp90 co-chaperone, decreased, but the interaction of cdc2 and cdc25c with the Hsp70 co-chaperone increased after ansamycin treatment.	Rifabutin	169-178	cyclin dependent kinase 1	Homo sapiens	28-32
17525741-10	2007	We conclude that ansamycins downregulate cdc2 and cdc25c by two different mechanisms.	Lactams, Macrocyclic	17-27	cyclin dependent kinase 1	Homo sapiens	41-45
17124554-0	2007	A synthetic uracil derivative with antitumor activity through decreasing cyclin D1 and Cdk1, and increasing p21 and p27 in MCF-7 cells.	Uracil	12-18	cyclin dependent kinase 1	Homo sapiens	87-91
17989878-6	2007	The accumulation of cyclinB1 protein and the suppression of Cdc2 tyrosine-15 and Cdc25C serine-216 phosphorylation were detected in irradiated cells treated with tetrandrine using Western blot analysis.	Tyrosine	65-73	cyclin dependent kinase 1	Homo sapiens	60-64
18225552-9	2007	Phosphorylation of Cdc2 at residue tyrosine-15 was also induced by Asc-S treatment.	Tyrosine	35-43	cyclin dependent kinase 1	Homo sapiens	19-23
17989878-6	2007	The accumulation of cyclinB1 protein and the suppression of Cdc2 tyrosine-15 and Cdc25C serine-216 phosphorylation were detected in irradiated cells treated with tetrandrine using Western blot analysis.	tetrandrine	162-173	cyclin dependent kinase 1	Homo sapiens	60-64
17585055-6	2007	Interestingly, while Cdk1 can phosphorylate p33(ING1b) at Ser-126 in nonstress conditions, Chk1 predominantly phosphorylates this residue on DNA damage, which suggests that p33(ING1b) is a downstream target of the ATM/ATR response cascade to genotoxic stress.	Serine	58-61	cyclin dependent kinase 1	Homo sapiens	21-25
18025287-0	2007	Baicalein induces cancer cell death and proliferation retardation by the inhibition of CDC2 kinase and survivin associated with opposite role of p38 mitogen-activated protein kinase and AKT.	baicalein	0-9	cyclin dependent kinase 1	Homo sapiens	87-91
17912454-1	2007	Human CDC25 phosphatases play an important role in cell cycle regulation by removing inhibitory phosphate groups on cyclin-CDKs.	Phosphates	96-105	cyclin dependent kinase 1	Homo sapiens	123-127
18025287-4	2007	The levels of cyclin B1 and phospho-CDC2 (Thr(161)) were reduced, whereas the G(2)-M phases were elevated by baicalein.	Threonine	42-45	cyclin dependent kinase 1	Homo sapiens	36-40
18025287-11	2007	SB203580, a specific p38 MAPK inhibitor, attenuated proliferation inhibition and restored the protein levels of phospho-CDC2 (Thr(161)) and survivin in the baicalein-exposed cells; conversely, blockade of AKT activation enhanced cytotoxicity and the reduction of phospho-CDC2 (Thr(161)) and survivin proteins.	SB 203580	0-8	cyclin dependent kinase 1	Homo sapiens	120-124
18025287-11	2007	SB203580, a specific p38 MAPK inhibitor, attenuated proliferation inhibition and restored the protein levels of phospho-CDC2 (Thr(161)) and survivin in the baicalein-exposed cells; conversely, blockade of AKT activation enhanced cytotoxicity and the reduction of phospho-CDC2 (Thr(161)) and survivin proteins.	SB 203580	0-8	cyclin dependent kinase 1	Homo sapiens	271-275
18025287-11	2007	SB203580, a specific p38 MAPK inhibitor, attenuated proliferation inhibition and restored the protein levels of phospho-CDC2 (Thr(161)) and survivin in the baicalein-exposed cells; conversely, blockade of AKT activation enhanced cytotoxicity and the reduction of phospho-CDC2 (Thr(161)) and survivin proteins.	Threonine	126-129	cyclin dependent kinase 1	Homo sapiens	120-124
17845507-4	2007	Western blot assay showed that chalcone significantly increases the expression of p21 and p27 proteins, and decreases the levels of cyclin B1, cyclin A and Cdc2, thereby contributing to cell cycle arrest.	Chalcone	31-39	cyclin dependent kinase 1	Homo sapiens	156-160
17636382-0	2007	New alternative phosphorylation sites on the cyclin dependent kinase 1/cyclin a complex in p53-deficient human cells treated with etoposide: possible association with etoposide-induced apoptosis.	Etoposide	130-139	cyclin dependent kinase 1	Homo sapiens	45-70
17636382-0	2007	New alternative phosphorylation sites on the cyclin dependent kinase 1/cyclin a complex in p53-deficient human cells treated with etoposide: possible association with etoposide-induced apoptosis.	Etoposide	167-176	cyclin dependent kinase 1	Homo sapiens	45-70
17636382-6	2007	The p53-negative myeloid leukemia cell lines K562 and HL-60 were used to determine Cdk1 phosphorylation status during etoposide treatment.	Etoposide	118-127	cyclin dependent kinase 1	Homo sapiens	83-87
17636382-7	2007	Cdk1 tyrosine 15 phosphorylation was associated with G2M arrest, but not with cell death.	Tyrosine	5-13	cyclin dependent kinase 1	Homo sapiens	0-4
17636382-8	2007	Cdk1 tyrosine 15 phosphorylation also led to suppression of nuclear cyclin B-associated Cdk1 kinase activity.	Tyrosine	5-13	cyclin dependent kinase 1	Homo sapiens	0-4
17636382-8	2007	Cdk1 tyrosine 15 phosphorylation also led to suppression of nuclear cyclin B-associated Cdk1 kinase activity.	Tyrosine	5-13	cyclin dependent kinase 1	Homo sapiens	88-92
17636382-9	2007	However cell death, associated with broader tyrosine phosphorylation of Cdk1 was not attributed to tyrosine 15 alone.	Tyrosine	44-52	cyclin dependent kinase 1	Homo sapiens	72-76
17636382-13	2007	These findings suggest novel Cdk1 phosphorylation sites, which appear to be associated with p53-independent cell death following etoposide treatment.	Etoposide	129-138	cyclin dependent kinase 1	Homo sapiens	29-33
17373649-5	2007	Exposing early G(2) cells to arsenite impeded cyclin B1 protein accumulation, Cdk1 activation, and G(2)-to-M progression.	arsenite	29-37	cyclin dependent kinase 1	Homo sapiens	78-82
17443687-7	2007	Here we show that the transition metal chelator TPEN (N,N,N",N"-tetrakis(2-pyridylmethyl) ethylene diamine) blocks the G2/M transition of the meiotic cell cycle by inhibiting Cdc25C-cdk1 activation.	Metals	33-38	cyclin dependent kinase 1	Homo sapiens	182-186
17443687-7	2007	Here we show that the transition metal chelator TPEN (N,N,N",N"-tetrakis(2-pyridylmethyl) ethylene diamine) blocks the G2/M transition of the meiotic cell cycle by inhibiting Cdc25C-cdk1 activation.	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	48-52	cyclin dependent kinase 1	Homo sapiens	182-186
17443687-9	2007	Interestingly, although apo-Cdc25C (Zn(2+)-deficient) remains fully catalytically active, it is compromised in its ability to dephosphorylate and activate MPF/cdk1.	Zinc	36-42	cyclin dependent kinase 1	Homo sapiens	159-163
17804748-5	2007	A selectivity study done on 32 kinases showed that, compared with variolin B, meriolins display enhanced specificity toward CDKs, with marked potency on CDK2 and CDK9.	meriolins	78-87	cyclin dependent kinase 1	Homo sapiens	124-128
17804748-8	2007	Phosphorylation at CDK1, CDK4, and CDK9 sites on, respectively, protein phosphatase 1alpha, retinoblastoma protein, and RNA polymerase II is inhibited in neuroblastoma SH-SY5Y cells exposed to meriolins.	meriolins	193-202	cyclin dependent kinase 1	Homo sapiens	19-23
17606321-10	2007	Treatment of the cells with either SPC or wortmannin increased the levels of p21, but decreased that of cyclin B1 and Cdc2.	Wortmannin	42-52	cyclin dependent kinase 1	Homo sapiens	118-122
17320279-10	2007	Analyzes of the molecular mechanisms underlying Go6976 induced mitosis showed that PKC inhibiting concentrations of Go6976 induced cdc2 activation concentration-dependently in non-synchronized and in DNA damaged cells.	Go 6976	48-54	cyclin dependent kinase 1	Homo sapiens	131-135
17320279-10	2007	Analyzes of the molecular mechanisms underlying Go6976 induced mitosis showed that PKC inhibiting concentrations of Go6976 induced cdc2 activation concentration-dependently in non-synchronized and in DNA damaged cells.	Go 6976	116-122	cyclin dependent kinase 1	Homo sapiens	131-135
17971903-5	2007	In p53-null PC-3 cells, prazosin induced an increase in DNA strand breaks and ATM/ATR checkpoint pathways, leading to the activation of downstream signaling cascades, including Cdc25c phosphorylation at Ser216, nuclear export of Cdc25c, and cyclin-dependent kinase (Cdk) 1 phosphorylation at Tyr15.	Prazosin	24-32	cyclin dependent kinase 1	Homo sapiens	241-272
17971903-6	2007	The data, together with sustained elevated cyclin A levels (other than cyclin B1 levels), suggested that Cdk1 activity was inactivated by prazosin.	Prazosin	138-146	cyclin dependent kinase 1	Homo sapiens	105-109
17971903-9	2007	In summary, we suggest that prazosin is a potential antitumor agent that induces cell apoptosis through the induction of DNA damage stress, leading to Cdk1 inactivation and G2 checkpoint arrest.	Prazosin	28-36	cyclin dependent kinase 1	Homo sapiens	151-155
17532631-0	2007	Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents.	pyrazolo(3,4-b)pyridine	28-51	cyclin dependent kinase 1	Homo sapiens	52-56
17638911-8	2007	Indeed, treatment with suberoylanilide hydroxamic acid greatly reduced the expression of the inhibitor of apoptosis protein survivin and cdc2 activity in HCT116 p21(+/+) cells but not in the HCT116 p21(-/-) cells.	Vorinostat	23-54	cyclin dependent kinase 1	Homo sapiens	137-141
17638911-9	2007	Inhibition of cdc2 activity with flavopiridol decreased survivin expression and sensitized the p21-deficient cells to lexatumumab-induced apoptosis.	alvocidib	33-45	cyclin dependent kinase 1	Homo sapiens	14-18
17545545-6	2007	Mifepristone blocked DNA synthesis, arrested the cell cycle at the G(1)-S transition, up-regulated cyclin-dependent kinase (cdk) inhibitors p21(cip1)and p27(kip1), down-regulated transcription factor E2F1, decreased expression of the E2F1-regulated genes cdk1 (cdc2) and cyclin A, and modestly decreased cdk2 and cyclin E levels.	Mifepristone	0-12	cyclin dependent kinase 1	Homo sapiens	255-259
17488717-3	2007	Here, we demonstrate that SIRT2 is phosphorylated both in vitro and in vivo on serine 368 by the cell-cycle regulator, cyclin-dependent kinase 1, and dephosphorylated by the phosphatases CDC14A and CDC14B.	Serine	79-85	cyclin dependent kinase 1	Homo sapiens	119-144
17475221-10	2007	The exposure of cells to 2-phenyl-4-quinolone caused Cdk1 activation by several observations, namely (i) elevation of cyclin B1 expression, (ii) dephosphorylation on inhibitory Tyr-15 of Cdk1, and (iii) dephosphorylation on Ser-216 of Cdc25c.	Serine	224-227	cyclin dependent kinase 1	Homo sapiens	187-191
17475222-5	2007	Guggulsterone suppressed the proliferation of cells through inhibition of DNA synthesis, producing cell cycle arrest in S-phase, and this arrest correlated with a decrease in the levels of cyclin D1 and cdc2 and a concomitant increase in the levels of cyclin-dependent kinase inhibitor p21 and p27.	pregna-4,17-diene-3,16-dione	0-13	cyclin dependent kinase 1	Homo sapiens	203-207
17475221-0	2007	Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways.	Quinolones	0-9	cyclin dependent kinase 1	Homo sapiens	77-81
17475221-10	2007	The exposure of cells to 2-phenyl-4-quinolone caused Cdk1 activation by several observations, namely (i) elevation of cyclin B1 expression, (ii) dephosphorylation on inhibitory Tyr-15 of Cdk1, and (iii) dephosphorylation on Ser-216 of Cdc25c.	2-phenyl-4-oxohydroquinoline	25-45	cyclin dependent kinase 1	Homo sapiens	53-57
17475221-10	2007	The exposure of cells to 2-phenyl-4-quinolone caused Cdk1 activation by several observations, namely (i) elevation of cyclin B1 expression, (ii) dephosphorylation on inhibitory Tyr-15 of Cdk1, and (iii) dephosphorylation on Ser-216 of Cdc25c.	2-phenyl-4-oxohydroquinoline	25-45	cyclin dependent kinase 1	Homo sapiens	187-191
17475221-10	2007	The exposure of cells to 2-phenyl-4-quinolone caused Cdk1 activation by several observations, namely (i) elevation of cyclin B1 expression, (ii) dephosphorylation on inhibitory Tyr-15 of Cdk1, and (iii) dephosphorylation on Ser-216 of Cdc25c.	Tyrosine	177-180	cyclin dependent kinase 1	Homo sapiens	53-57
17475221-10	2007	The exposure of cells to 2-phenyl-4-quinolone caused Cdk1 activation by several observations, namely (i) elevation of cyclin B1 expression, (ii) dephosphorylation on inhibitory Tyr-15 of Cdk1, and (iii) dephosphorylation on Ser-216 of Cdc25c.	Serine	224-227	cyclin dependent kinase 1	Homo sapiens	53-57
17545545-6	2007	Mifepristone blocked DNA synthesis, arrested the cell cycle at the G(1)-S transition, up-regulated cyclin-dependent kinase (cdk) inhibitors p21(cip1)and p27(kip1), down-regulated transcription factor E2F1, decreased expression of the E2F1-regulated genes cdk1 (cdc2) and cyclin A, and modestly decreased cdk2 and cyclin E levels.	Mifepristone	0-12	cyclin dependent kinase 1	Homo sapiens	261-265
17389604-5	2007	Moreover, we found cyclin B1/Cdk1 to phosphorylate NIPA at Ser-395 in mitosis.	Serine	59-62	cyclin dependent kinase 1	Homo sapiens	29-33
17389604-7	2007	These data are compatible with a process of sequential NIPA phosphorylation where cyclin B1/Cdk1 amplifies phosphorylation of NIPA once an initial phosphorylation event has dissociated the SCFNIPA complex.	scfnipa	189-196	cyclin dependent kinase 1	Homo sapiens	92-96
17412972-4	2007	To characterize the mechanism further, Western blots of ORF20-recombinant lentivirus-infected cells were developed with antibodies to cyclin B1, Cdc2 and phospho-Tyr-15-Cdc2.	Tyrosine	162-165	cyclin dependent kinase 1	Homo sapiens	169-173
17160019-7	2007	We also found that Wnt signal activation increased phosphorylation of Cdc2 (Cdk1) that inhibited its activity, and suppressed apoptosis upon exposure of the cells to nocodazole or colcemid.	Nocodazole	166-176	cyclin dependent kinase 1	Homo sapiens	70-74
17160019-7	2007	We also found that Wnt signal activation increased phosphorylation of Cdc2 (Cdk1) that inhibited its activity, and suppressed apoptosis upon exposure of the cells to nocodazole or colcemid.	Nocodazole	166-176	cyclin dependent kinase 1	Homo sapiens	76-80
17324379-0	2007	Geldanamycin induces G2 arrest in U87MG glioblastoma cells through downregulation of Cdc2 and cyclin B1.	geldanamycin	0-12	cyclin dependent kinase 1	Homo sapiens	85-89
17324379-6	2007	And phosphorylated Cdc2 decreased along with Cdc2 in the GA-treated cells.	geldanamycin	57-59	cyclin dependent kinase 1	Homo sapiens	19-23
17324379-6	2007	And phosphorylated Cdc2 decreased along with Cdc2 in the GA-treated cells.	geldanamycin	57-59	cyclin dependent kinase 1	Homo sapiens	45-49
17324379-10	2007	Cdc2 and cyclin B1 were ubiquitinated by GA. MG132 abrogated the GA-induced decrease of Cdc2 and cyclin B1 indicating that these proteins were degraded by proteasomes.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	45-50	cyclin dependent kinase 1	Homo sapiens	0-4
17324379-10	2007	Cdc2 and cyclin B1 were ubiquitinated by GA. MG132 abrogated the GA-induced decrease of Cdc2 and cyclin B1 indicating that these proteins were degraded by proteasomes.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	45-50	cyclin dependent kinase 1	Homo sapiens	88-92
17324379-10	2007	Cdc2 and cyclin B1 were ubiquitinated by GA. MG132 abrogated the GA-induced decrease of Cdc2 and cyclin B1 indicating that these proteins were degraded by proteasomes.	geldanamycin	41-43	cyclin dependent kinase 1	Homo sapiens	0-4
17324379-11	2007	In conclusion, GA controls the stability of Cdc2 and cyclin B1 in glioblastomas cell species-dependently.	geldanamycin	15-17	cyclin dependent kinase 1	Homo sapiens	44-48
17410604-0	2007	In vitro effects of 2-methoxyestradiol on cell morphology and Cdc2 kinase activity in SNO oesophageal carcinoma cells.	2-Methoxyestradiol	20-38	cyclin dependent kinase 1	Homo sapiens	62-66
17340628-6	2007	The G2/M arrest was accompanied by elevated Cdc2 kinase activity, an increase in expression of cyclin B1 and phosphorylated Cdc2 (Thr 161), and a decrease in expression of phosphorylated Cdc2 (Tyr 15), Myt-1, and interphase Cdc25C.	Threonine	130-133	cyclin dependent kinase 1	Homo sapiens	124-128
17340628-6	2007	The G2/M arrest was accompanied by elevated Cdc2 kinase activity, an increase in expression of cyclin B1 and phosphorylated Cdc2 (Thr 161), and a decrease in expression of phosphorylated Cdc2 (Tyr 15), Myt-1, and interphase Cdc25C.	Threonine	130-133	cyclin dependent kinase 1	Homo sapiens	124-128
17412972-5	2007	This analysis revealed a relative increase in cyclin B and phospho-Tyr-15-Cdc2, from 24 to 72 h after infection with recombinant lentivirus.	Tyrosine	67-70	cyclin dependent kinase 1	Homo sapiens	74-78
17419986-2	2007	In a recent issue of Cancer Cell, Vecchione and coworkers report that the protein product of the tumor suppressor gene Lzts1 (Leucine zipper tumor suppressor-1) binds the Cdk1 phosphatase Cdc25C and stabilizes it by protecting it from proteasomal degradation (Vecchione et al., 2007).	vecchione	34-43	cyclin dependent kinase 1	Homo sapiens	171-175
17301055-6	2007	Drp1 was specifically phosphorylated in mitosis by Cdk1/cyclin B on Ser-585.	Serine	68-71	cyclin dependent kinase 1	Homo sapiens	51-55
17457045-7	2007	In addition, mechanistic study elucidated that Pa induced cell cycle arrest at G2/M phase and inhibited the expressions of G2/M phase cell cycle regulatory proteins, cyclin-A1 and cdc2 in a dose-dependent manner.	pheophorbide a	47-49	cyclin dependent kinase 1	Homo sapiens	180-184
17290426-8	2007	We modulated checkpoint-related gene expression in testis using the anti-metabolite, 5-fluorouracil, resulting in increased apoptosis and upregulation of Chk1 (P&lt;0.0001) and Cdc2 (P&lt;0.02) mRNA.	Fluorouracil	85-99	cyclin dependent kinase 1	Homo sapiens	177-181
17474786-0	2007	Purvalanol A enhances cell killing by inhibiting up-regulation of CDC2 kinase activity in tumor cells irradiated with high doses of X rays.	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	0-12	cyclin dependent kinase 1	Homo sapiens	66-70
17474786-5	2007	These results suggest that the inhibition of radiation-induced CDC2 kinase activity by purvalanol A induces apoptosis through the enhancement of active fragments of caspase 3.	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	87-99	cyclin dependent kinase 1	Homo sapiens	63-67
17408621-7	2007	We have also identified serine 1436 as one FLNa residue phosphorylated by cyclin B1/Cdk1 in vitro.	Serine	24-30	cyclin dependent kinase 1	Homo sapiens	84-88
17303421-0	2007	Synthesis and activity of quinolinyl-methylene-thiazolinones as potent and selective cyclin-dependent kinase 1 inhibitors.	quinolinyl-methylene-thiazolinones	26-60	cyclin dependent kinase 1	Homo sapiens	85-110
17303421-1	2007	A novel series of quinolinyl-methylene-thiazolinones has been identified as potent and selective cyclin-dependent kinase 1 (CDK1) inhibitors.	quinolinyl-methylene-thiazolinones	18-52	cyclin dependent kinase 1	Homo sapiens	97-122
17303421-1	2007	A novel series of quinolinyl-methylene-thiazolinones has been identified as potent and selective cyclin-dependent kinase 1 (CDK1) inhibitors.	quinolinyl-methylene-thiazolinones	18-52	cyclin dependent kinase 1	Homo sapiens	124-128
17234412-0	2007	Synthesis of 3-(1H-benzimidazol-2-yl)-5-isoquinolin-4-ylpyrazolo[1,2-b]pyridine, a potent cyclin dependent kinase 1 (CDK1) inhibitor.	3-(1H-benzimidazol-2-yl)-5-isoquinolin-4-ylpyrazolo(1,2-b)pyridine	13-79	cyclin dependent kinase 1	Homo sapiens	90-115
17431114-7	2007	TAE226 retarded tumor cell growth as assessed by a cell viability assay and attenuated G(2)-M cell cycle progression associated with a decrease in cyclin B1 and phosphorylated cdc2 (Tyr(15)) protein expression.	TAE226	0-6	cyclin dependent kinase 1	Homo sapiens	176-180
17210576-3	2007	A requirement for PP2A by Vpr was first shown with the PP2A-specific inhibitor okadaic acid, which reduced Vpr-induced G(2) arrest and Cdk1-Tyr(15) phosphorylation.	Okadaic Acid	79-91	cyclin dependent kinase 1	Homo sapiens	135-139
17210576-3	2007	A requirement for PP2A by Vpr was first shown with the PP2A-specific inhibitor okadaic acid, which reduced Vpr-induced G(2) arrest and Cdk1-Tyr(15) phosphorylation.	Tyrosine	140-143	cyclin dependent kinase 1	Homo sapiens	135-139
17178224-2	2007	Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells.	isothiazolidine 1,1-dioxide	0-27	cyclin dependent kinase 1	Homo sapiens	52-56
17454637-1	2007	Tetra-O-methyl nordihydroguaiaretic acid (M4N) was shown to induce G2 arrest and suppress human xenograft tumor growth by inhibiting Cdc2 and survivin.	terameprocol	42-45	cyclin dependent kinase 1	Homo sapiens	133-137
17374997-2	2007	As an arterial SMC prepares for a G2/M transition, the cell has primed the Cdc2/cyclinB1 complex for activation by the phosphorylation of threonine-161 residue on Cdc2.	Threonine	138-147	cyclin dependent kinase 1	Homo sapiens	75-79
17374997-2	2007	As an arterial SMC prepares for a G2/M transition, the cell has primed the Cdc2/cyclinB1 complex for activation by the phosphorylation of threonine-161 residue on Cdc2.	Threonine	138-147	cyclin dependent kinase 1	Homo sapiens	163-167
17182611-4	2007	Addition of caffeine to spindle checkpoint-arrested cells induced &gt;40% apoptosis within 5 h. It also caused proteasome-mediated destruction of cyclin B1, a corresponding reduction in cyclin B1/cdk1 activity, and reduction in MPM-2 reactivity.	Caffeine	12-20	cyclin dependent kinase 1	Homo sapiens	196-200
17148446-8	2007	In addition, curcumin treatment reduces cell number, which is associated with a reduced cyclin and cdk1 levels.	Curcumin	13-21	cyclin dependent kinase 1	Homo sapiens	99-103
17234412-0	2007	Synthesis of 3-(1H-benzimidazol-2-yl)-5-isoquinolin-4-ylpyrazolo[1,2-b]pyridine, a potent cyclin dependent kinase 1 (CDK1) inhibitor.	3-(1H-benzimidazol-2-yl)-5-isoquinolin-4-ylpyrazolo(1,2-b)pyridine	13-79	cyclin dependent kinase 1	Homo sapiens	117-121
17234412-1	2007	The novel compound 3-(1H-benzimidazol-2-yl)-5-isoquinolin-4-ylpyrazolo[1,2-b]pyridine was discovered to be a potent CDK1 inhibitor.	3-(1H-benzimidazol-2-yl)-5-isoquinolin-4-ylpyrazolo(1,2-b)pyridine	19-85	cyclin dependent kinase 1	Homo sapiens	116-120
17273739-8	2007	Inhibition of p38 MAPK by its inhibitor SB203580 not only attenuated LDM-induced G2 arrest but also potentiated LDM-induced apoptosis, which was accompanied by decreasing phosphorylation of Cdc2 and increasing expression of FasL and phosphorylation of JNK.	SB 203580	40-48	cyclin dependent kinase 1	Homo sapiens	190-194
17012222-0	2007	Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells.	gambogic acid	0-13	cyclin dependent kinase 1	Homo sapiens	99-103
17012222-3	2007	Western blot analysis demonstrated that GA-induced cell-cycle arrest in BGC-823 cells was associated with a significant decrease in CDC2/p34 synthesis, which led to the accumulation of phosphorylated-Tyr(15) (inactive) form of CDC2/p34.	gambogic acid	40-42	cyclin dependent kinase 1	Homo sapiens	132-136
17012222-3	2007	Western blot analysis demonstrated that GA-induced cell-cycle arrest in BGC-823 cells was associated with a significant decrease in CDC2/p34 synthesis, which led to the accumulation of phosphorylated-Tyr(15) (inactive) form of CDC2/p34.	gambogic acid	40-42	cyclin dependent kinase 1	Homo sapiens	227-231
17012222-4	2007	Real-time PCR, western blot and kinase activity assays revealed that GA-induced reduction of CDC2/p34 expression was mediated through the inhibition of cyclin-dependent kinase (CDK)-activating kinase (CDK7/cyclin H) activity.	gambogic acid	69-71	cyclin dependent kinase 1	Homo sapiens	93-97
17012222-5	2007	In addition, GA-treated cells were shown to have a low level of CDK7 kinase-phosphorylated-Thr(161) CDC2/p34 (active).	gambogic acid	13-15	cyclin dependent kinase 1	Homo sapiens	100-104
17012222-5	2007	In addition, GA-treated cells were shown to have a low level of CDK7 kinase-phosphorylated-Thr(161) CDC2/p34 (active).	Threonine	91-94	cyclin dependent kinase 1	Homo sapiens	100-104
17125805-1	2007	Roscovitine potently inhibits cyclin-dependent kinases (CDK) and can independently slow the closing of neuronal (CaV2.2) calcium channels.	Roscovitine	0-11	cyclin dependent kinase 1	Homo sapiens	56-59
17125805-9	2007	Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.	Roscovitine	36-47	cyclin dependent kinase 1	Homo sapiens	114-118
17050787-9	2007	In contrast, cyclin B and Cdk1 expression and cyclin B/Cdk1 kinase activity were decreased in both cell lines in the presence of resveratrol.	Resveratrol	129-140	cyclin dependent kinase 1	Homo sapiens	26-30
17050787-9	2007	In contrast, cyclin B and Cdk1 expression and cyclin B/Cdk1 kinase activity were decreased in both cell lines in the presence of resveratrol.	Resveratrol	129-140	cyclin dependent kinase 1	Homo sapiens	55-59
16972069-2	2007	In this paper, we have investigated whether cell cycle transit and or Cdc2 (Cdk1) activity is required for the apoptosis induced by PTX.	Paclitaxel	132-135	cyclin dependent kinase 1	Homo sapiens	70-74
17291761-5	2007	Cells treated with BI 2536 are delayed in prophase but eventually import Cdk1-cyclin B into the nucleus, enter prometaphase, and degrade cyclin A, although BI 2536 prevents degradation of the APC/C inhibitor Emi1.	BI 2536	19-26	cyclin dependent kinase 1	Homo sapiens	73-77
17095507-1	2007	Inhibition of cyclin-dependent kinase 1 (CDK1) activity by Tyr-15 phosphorylation directly regulates entry into mitosis and is an important element in the control of the unperturbed cell cycle.	Tyrosine	59-62	cyclin dependent kinase 1	Homo sapiens	14-39
17095507-1	2007	Inhibition of cyclin-dependent kinase 1 (CDK1) activity by Tyr-15 phosphorylation directly regulates entry into mitosis and is an important element in the control of the unperturbed cell cycle.	Tyrosine	59-62	cyclin dependent kinase 1	Homo sapiens	41-45
16972069-2	2007	In this paper, we have investigated whether cell cycle transit and or Cdc2 (Cdk1) activity is required for the apoptosis induced by PTX.	Paclitaxel	132-135	cyclin dependent kinase 1	Homo sapiens	76-80
16519995-8	2007	The expression of Cyclin D, Cyclin E, CDK 4, CDK 1 and PCNA were down regulated over the time in GTP and EGCG treated experimental group, compared to the untreated control group as evaluated by western blot analysis for cell cycle proteins, which corroborated the G1 block.	epigallocatechin gallate	97-100	cyclin dependent kinase 1	Homo sapiens	45-50
17386461-1	2007	The least-squares support vector machines (LS-SVMs), as an effective modified algorithm of support vector machine, was used to build structure-activity relationship (SAR) models to classify the oxindole-based inhibitors of cyclin-dependent kinases (CDKs) based on their activity.	2-oxindole	194-202	cyclin dependent kinase 1	Homo sapiens	249-253
17179992-1	2007	Seliciclib (CYC202; R-roscovitine) is the first selective, orally bioavailable inhibitor of cyclin-dependent kinases 1, 2, 7 and 9 to enter clinical trial.	Roscovitine	0-10	cyclin dependent kinase 1	Homo sapiens	92-130
17179992-1	2007	Seliciclib (CYC202; R-roscovitine) is the first selective, orally bioavailable inhibitor of cyclin-dependent kinases 1, 2, 7 and 9 to enter clinical trial.	Roscovitine	12-18	cyclin dependent kinase 1	Homo sapiens	92-130
17179992-1	2007	Seliciclib (CYC202; R-roscovitine) is the first selective, orally bioavailable inhibitor of cyclin-dependent kinases 1, 2, 7 and 9 to enter clinical trial.	Roscovitine	20-33	cyclin dependent kinase 1	Homo sapiens	92-130
16519995-8	2007	The expression of Cyclin D, Cyclin E, CDK 4, CDK 1 and PCNA were down regulated over the time in GTP and EGCG treated experimental group, compared to the untreated control group as evaluated by western blot analysis for cell cycle proteins, which corroborated the G1 block.	epigallocatechin gallate	105-109	cyclin dependent kinase 1	Homo sapiens	45-50
17085048-0	2007	Nitrogen-containing flavonoids as CDK1/Cyclin B inhibitors: design, synthesis, and biological evaluation.	Nitrogen	0-8	cyclin dependent kinase 1	Homo sapiens	34-38
17569210-6	2007	Curcumin arrested the cell cycle by preventing the expression of cyclin D1, cdk-1 and cdc-25.	Curcumin	0-8	cyclin dependent kinase 1	Homo sapiens	76-81
17085048-0	2007	Nitrogen-containing flavonoids as CDK1/Cyclin B inhibitors: design, synthesis, and biological evaluation.	Flavonoids	20-30	cyclin dependent kinase 1	Homo sapiens	34-38
17085048-1	2007	A novel series of nitrogen-containing flavonoids 5a-l, 6a,b, and 7a,b were designed and synthesized as cyclin-dependent kinases (CDKs) inhibitors.	Nitrogen	18-26	cyclin dependent kinase 1	Homo sapiens	129-133
17085048-1	2007	A novel series of nitrogen-containing flavonoids 5a-l, 6a,b, and 7a,b were designed and synthesized as cyclin-dependent kinases (CDKs) inhibitors.	Flavonoids	38-48	cyclin dependent kinase 1	Homo sapiens	129-133
17031514-5	2007	We evaluated growth-inhibitory activity of flavanone and 2"-OH flavanone against highly proliferative human lung cancer cells (A549) via anchorage-independent and -dependent colony formation assay, and further showed that treatment of flavanone resulted in a G1 cell cycle arrest with reduction of cyclin D, E and cyclin-dependent kinase (CDK) 2, while treatment of 2"-OH flavanone led to a G2/M phase accumulation with reduction of cyclin B, D and Cdc2.	flavanone	43-52	cyclin dependent kinase 1	Homo sapiens	449-453
17129359-3	2007	In addition, ZER induced the phosphorylation of Cdc25C at the Thr48 residue and Cdc2 at the Thr14/Tyr15 residues.	zerumbone	13-16	cyclin dependent kinase 1	Homo sapiens	48-52
17102938-9	2006	It also induced several pathways, including cyclin B1 up-regulation, dephosphorylation on Tyr(15) and phosphorylation on Thr(161) of Cdk1 and Cdc25C phosphorylation, and roscovitine (a Cdk1 inhibitor) significantly inhibited K2154-induced apoptosis, suggesting a pro-apoptotic role of Cdk1.	Threonine	121-124	cyclin dependent kinase 1	Homo sapiens	133-137
16854366-7	2006	These results support a model where Ca(2+)/calmodulin and cdk1 dynamically control caldesmon inhibition of tropomyosin-activated actomyosin to regulate division speed and to suppress membrane blebs.	tropomyosin-activated actomyosin	107-139	cyclin dependent kinase 1	Homo sapiens	58-62
17172867-0	2006	Human Cdc14A reverses CDK1 phosphorylation of Cdc25A on serines 115 and 320.	Serine	56-63	cyclin dependent kinase 1	Homo sapiens	22-26
17172867-5	2006	Specifically, the Cdk1/Cyclin-B1-dependent phosphate groups on Ser115 and Ser320 of Cdc25A were found to be removed by Cdc14A.	Phosphates	43-52	cyclin dependent kinase 1	Homo sapiens	18-22
17065226-7	2006	Interestingly, coincident with the accumulation of cells in the S/G2/M phase and histone H1 phosphorylation, E1A was relocated to the cytoplasm at the late stage of the viral cycle, which was blocked by the CDC2/CDK2 inhibitor roscovitine.	Roscovitine	227-238	cyclin dependent kinase 1	Homo sapiens	207-211
17172433-4	2006	Additional mechanistic studies showed that gallic acid induces an early Tyr(15) phosphorylation of cell division cycle 2 (cdc2).	Gallic Acid	43-54	cyclin dependent kinase 1	Homo sapiens	99-120
17172433-4	2006	Additional mechanistic studies showed that gallic acid induces an early Tyr(15) phosphorylation of cell division cycle 2 (cdc2).	Gallic Acid	43-54	cyclin dependent kinase 1	Homo sapiens	122-126
17172433-4	2006	Additional mechanistic studies showed that gallic acid induces an early Tyr(15) phosphorylation of cell division cycle 2 (cdc2).	Tyrosine	72-75	cyclin dependent kinase 1	Homo sapiens	99-120
17172433-4	2006	Additional mechanistic studies showed that gallic acid induces an early Tyr(15) phosphorylation of cell division cycle 2 (cdc2).	Tyrosine	72-75	cyclin dependent kinase 1	Homo sapiens	122-126
17172433-6	2006	Time kinetics of ATM phosphorylation, together with those of H2A.X and Chk2, was in accordance with an inactivating phosphorylation of cdc25A and cdc25C phosphatases and cdc2 kinase, suggesting that gallic acid increases cdc25A/C-cdc2 phosphorylation and thereby inactivation via ATM-Chk2 pathway following DNA damage that induces cell cycle arrest.	Gallic Acid	199-210	cyclin dependent kinase 1	Homo sapiens	135-139
17266627-0	2007	3D-QSAR CoMFA study on oxindole derivatives as cyclin dependent kinase 1 (CDK1) and cyclin dependent kinase 2 (CDK2) inhibitors.	2-oxindole	23-31	cyclin dependent kinase 1	Homo sapiens	47-72
17266627-0	2007	3D-QSAR CoMFA study on oxindole derivatives as cyclin dependent kinase 1 (CDK1) and cyclin dependent kinase 2 (CDK2) inhibitors.	2-oxindole	23-31	cyclin dependent kinase 1	Homo sapiens	74-78
17266627-2	2007	With the purpose of designing new chemical entities with enhanced inhibitory potencies against cyclin dependent kinase 2 (CDK2) and cyclin dependent kinase 1 (CDK1), the 3D-QSAR CoMFA study carried out on oxindole derivatives as inhibitors of these kinases is presented here.	2-oxindole	205-213	cyclin dependent kinase 1	Homo sapiens	132-157
17266627-2	2007	With the purpose of designing new chemical entities with enhanced inhibitory potencies against cyclin dependent kinase 2 (CDK2) and cyclin dependent kinase 1 (CDK1), the 3D-QSAR CoMFA study carried out on oxindole derivatives as inhibitors of these kinases is presented here.	2-oxindole	205-213	cyclin dependent kinase 1	Homo sapiens	159-163
17206862-6	2007	Broad inhibition of cell cycle-regulated kinases (Cdk1/Cdk2/Cdk5/Cdk9) with indirubin-3"-monoxime substantially decreases viral yields and synergizes with the viral UL97 kinase inhibitor, maribavir.	indirubin-3'-monoxime	76-97	cyclin dependent kinase 1	Homo sapiens	50-54
17206862-6	2007	Broad inhibition of cell cycle-regulated kinases (Cdk1/Cdk2/Cdk5/Cdk9) with indirubin-3"-monoxime substantially decreases viral yields and synergizes with the viral UL97 kinase inhibitor, maribavir.	maribavir	188-197	cyclin dependent kinase 1	Homo sapiens	50-54
16996651-4	2006	Surprisingly, compound E2GG, a pyrazolo[4,3-d]pyrimidine analogue of myoseverin, displayed inhibitory activity towards both tubulin polymerization and the activity of cyclin-dependent kinases 1, 2 and 7.	e2gg	23-27	cyclin dependent kinase 1	Homo sapiens	167-202
16996651-4	2006	Surprisingly, compound E2GG, a pyrazolo[4,3-d]pyrimidine analogue of myoseverin, displayed inhibitory activity towards both tubulin polymerization and the activity of cyclin-dependent kinases 1, 2 and 7.	myoseverin	69-79	cyclin dependent kinase 1	Homo sapiens	167-202
17070718-3	2006	Inhibition of an ATP analog-sensitive allele of Cdk1 completely blocked the addition of telomere repeats.	Adenosine Triphosphate	17-20	cyclin dependent kinase 1	Homo sapiens	48-52
16889755-5	2006	AS101 induced G(2)/M growth arrest and increased both cyclin-dependent kinase inhibitor p21(waf1) protein levels and Cdk1 (p34(cdc2))-inhibitory phosphorylation.	ammonium trichloro(dioxoethylene-O,O'-)tellurate	0-5	cyclin dependent kinase 1	Homo sapiens	117-121
16889755-5	2006	AS101 induced G(2)/M growth arrest and increased both cyclin-dependent kinase inhibitor p21(waf1) protein levels and Cdk1 (p34(cdc2))-inhibitory phosphorylation.	ammonium trichloro(dioxoethylene-O,O'-)tellurate	0-5	cyclin dependent kinase 1	Homo sapiens	127-131
17172841-4	2006	Recently, a selective CDK1 inhibitor, RO-3306, has been identified that reversibly arrests proliferating human cells at the G2/M phase border and provides a novel means for cell cycle synchronization.	RO 3306	38-45	cyclin dependent kinase 1	Homo sapiens	22-26
17013563-4	2006	Interestingly, this increase in CDK1 and apoptosis by ionizing radiation was prevented by pretreatment with the CDK1 inhibitor, roscovitine, suggesting that CDK1 kinase activity is required for radiation-induced apoptotic cell death in this model system.	Roscovitine	128-139	cyclin dependent kinase 1	Homo sapiens	32-36
17013563-4	2006	Interestingly, this increase in CDK1 and apoptosis by ionizing radiation was prevented by pretreatment with the CDK1 inhibitor, roscovitine, suggesting that CDK1 kinase activity is required for radiation-induced apoptotic cell death in this model system.	Roscovitine	128-139	cyclin dependent kinase 1	Homo sapiens	112-116
17013563-4	2006	Interestingly, this increase in CDK1 and apoptosis by ionizing radiation was prevented by pretreatment with the CDK1 inhibitor, roscovitine, suggesting that CDK1 kinase activity is required for radiation-induced apoptotic cell death in this model system.	Roscovitine	128-139	cyclin dependent kinase 1	Homo sapiens	112-116
17172841-7	2006	RO-3306 represents a new molecular tool for studying CDK1 function in human cells.	RO 3306	0-7	cyclin dependent kinase 1	Homo sapiens	53-57
17013563-5	2006	Furthermore, cyclin B1 and CDK1 were detected co-localizing and associating in G1 phase MOLT-4 cells, with the cellular lysates from these cells revealing a genotoxic stress-induced increase in CDK1 phosphorylation (Thr-161) and dephosphorylation (Tyr-15), as analyzed by postsorting immunoprecipitation and immunoblotting.	Threonine	216-219	cyclin dependent kinase 1	Homo sapiens	27-31
17013563-5	2006	Furthermore, cyclin B1 and CDK1 were detected co-localizing and associating in G1 phase MOLT-4 cells, with the cellular lysates from these cells revealing a genotoxic stress-induced increase in CDK1 phosphorylation (Thr-161) and dephosphorylation (Tyr-15), as analyzed by postsorting immunoprecipitation and immunoblotting.	Threonine	216-219	cyclin dependent kinase 1	Homo sapiens	194-198
16733797-5	2006	Analysis of the cell cycle regulatory proteins demonstrated that THDA did not change the steady-state levels of cyclin B1, cyclin D3 and Cdc25C, but decreased the protein levels of Cdk1, Cdk2 and cyclin A.	thda	65-69	cyclin dependent kinase 1	Homo sapiens	181-185
17013563-5	2006	Furthermore, cyclin B1 and CDK1 were detected co-localizing and associating in G1 phase MOLT-4 cells, with the cellular lysates from these cells revealing a genotoxic stress-induced increase in CDK1 phosphorylation (Thr-161) and dephosphorylation (Tyr-15), as analyzed by postsorting immunoprecipitation and immunoblotting.	Tyrosine	248-251	cyclin dependent kinase 1	Homo sapiens	27-31
17013563-5	2006	Furthermore, cyclin B1 and CDK1 were detected co-localizing and associating in G1 phase MOLT-4 cells, with the cellular lysates from these cells revealing a genotoxic stress-induced increase in CDK1 phosphorylation (Thr-161) and dephosphorylation (Tyr-15), as analyzed by postsorting immunoprecipitation and immunoblotting.	Tyrosine	248-251	cyclin dependent kinase 1	Homo sapiens	194-198
16387422-3	2006	As a tubulin-binding agent (TBA), Casticin induces p21, which in turn inhibits Cdk1.	tba	28-31	cyclin dependent kinase 1	Homo sapiens	79-83
16387422-3	2006	As a tubulin-binding agent (TBA), Casticin induces p21, which in turn inhibits Cdk1.	casticin	34-42	cyclin dependent kinase 1	Homo sapiens	79-83
17043241-3	2006	The decline in AR protein expression mediated by the Cdk inhibitor roscovitine was prevented by proteosome inhibitors, indicating that Cdk1 stabilizes AR protein, although roscovitine also decreased AR message levels.	Roscovitine	67-78	cyclin dependent kinase 1	Homo sapiens	135-139
17015169-6	2006	THIF inhibited cdc2 activation via the phosphorylation of p38 MAP kinase, suggesting that this species may mediate genistein"s cellular actions.	orobol	0-4	cyclin dependent kinase 1	Homo sapiens	15-19
17015169-7	2006	THIF exposure activated p38 and caused subsequent inhibition of cyclin B1 (Ser 147) and cdc2 (Thr 161) phosphorylation, two events critical for the correct functioning of the cdc2-cyclin B1 complex.	orobol	0-4	cyclin dependent kinase 1	Homo sapiens	88-92
17015169-7	2006	THIF exposure activated p38 and caused subsequent inhibition of cyclin B1 (Ser 147) and cdc2 (Thr 161) phosphorylation, two events critical for the correct functioning of the cdc2-cyclin B1 complex.	orobol	0-4	cyclin dependent kinase 1	Homo sapiens	175-179
17043241-2	2006	Here we show that cyclin-dependent kinase 1 (Cdk1) mediates AR phosphorylation at Ser-81 and increases AR protein expression, and that Cdk1 inhibitors decrease AR Ser-81 phosphorylation, protein expression, and transcriptional activity in prostate cancer (PCa) cells.	Serine	82-85	cyclin dependent kinase 1	Homo sapiens	18-43
17015169-7	2006	THIF exposure activated p38 and caused subsequent inhibition of cyclin B1 (Ser 147) and cdc2 (Thr 161) phosphorylation, two events critical for the correct functioning of the cdc2-cyclin B1 complex.	Threonine	94-97	cyclin dependent kinase 1	Homo sapiens	88-92
17043241-7	2006	Taken together, these findings identify Cdk1 as a Ser-81 kinase and indicate that Cdk1 stabilizes AR protein by phosphorylation at a site(s) distinct from Ser-81.	Serine	50-53	cyclin dependent kinase 1	Homo sapiens	40-44
17015169-7	2006	THIF exposure activated p38 and caused subsequent inhibition of cyclin B1 (Ser 147) and cdc2 (Thr 161) phosphorylation, two events critical for the correct functioning of the cdc2-cyclin B1 complex.	Threonine	94-97	cyclin dependent kinase 1	Homo sapiens	175-179
17043241-2	2006	Here we show that cyclin-dependent kinase 1 (Cdk1) mediates AR phosphorylation at Ser-81 and increases AR protein expression, and that Cdk1 inhibitors decrease AR Ser-81 phosphorylation, protein expression, and transcriptional activity in prostate cancer (PCa) cells.	Serine	82-85	cyclin dependent kinase 1	Homo sapiens	45-49
17043241-2	2006	Here we show that cyclin-dependent kinase 1 (Cdk1) mediates AR phosphorylation at Ser-81 and increases AR protein expression, and that Cdk1 inhibitors decrease AR Ser-81 phosphorylation, protein expression, and transcriptional activity in prostate cancer (PCa) cells.	Serine	163-166	cyclin dependent kinase 1	Homo sapiens	45-49
17043241-2	2006	Here we show that cyclin-dependent kinase 1 (Cdk1) mediates AR phosphorylation at Ser-81 and increases AR protein expression, and that Cdk1 inhibitors decrease AR Ser-81 phosphorylation, protein expression, and transcriptional activity in prostate cancer (PCa) cells.	Serine	163-166	cyclin dependent kinase 1	Homo sapiens	135-139
16876403-0	2006	Structure-based drug design of a highly potent CDK1,2,4,6 inhibitor with novel macrocyclic quinoxalin-2-one structure.	2-hydroxyquinoxaline	91-107	cyclin dependent kinase 1	Homo sapiens	47-51
17015473-3	2006	Here, we report that phosphorylation of AML1 serines 276 and 303 can be blocked in vivo by inhibitors of the cyclin-dependent kinases (CDKs) Cdk1 and Cdk2.	Serine	45-52	cyclin dependent kinase 1	Homo sapiens	135-139
17015473-3	2006	Here, we report that phosphorylation of AML1 serines 276 and 303 can be blocked in vivo by inhibitors of the cyclin-dependent kinases (CDKs) Cdk1 and Cdk2.	Serine	45-52	cyclin dependent kinase 1	Homo sapiens	141-145
16969115-2	2006	Roscovitine arrests cell cycle progression in G(1) and in G(2) phase by inhibiting CDK2 and CDK1, and possibly CDK7 and CDK9.	Roscovitine	0-11	cyclin dependent kinase 1	Homo sapiens	92-96
16870444-0	2006	Synthesis of 2-amino-4-(7-azaindol-3-yl)pyrimidines as cyclin dependent kinase 1 (CDK1) inhibitors.	2-amino-4-(7-azaindol-3-yl)pyrimidines	13-51	cyclin dependent kinase 1	Homo sapiens	55-80
16870444-0	2006	Synthesis of 2-amino-4-(7-azaindol-3-yl)pyrimidines as cyclin dependent kinase 1 (CDK1) inhibitors.	2-amino-4-(7-azaindol-3-yl)pyrimidines	13-51	cyclin dependent kinase 1	Homo sapiens	82-86
16870444-1	2006	A novel series of 2-amino-4-(7-azaindol-3-yl)pyrimidines was discovered as cyclin dependent kinase 1 (CDK1) inhibitors.	2-amino-4-(7-azaindol-3-yl)pyrimidines	18-56	cyclin dependent kinase 1	Homo sapiens	75-100
16870444-1	2006	A novel series of 2-amino-4-(7-azaindol-3-yl)pyrimidines was discovered as cyclin dependent kinase 1 (CDK1) inhibitors.	2-amino-4-(7-azaindol-3-yl)pyrimidines	18-56	cyclin dependent kinase 1	Homo sapiens	102-106
16794187-4	2006	Consistent with the cell-cycle effects, at a molecular level (Western blots), 2-ME inhibited cyclin D(1) and cyclin B(1) expression; cyclin-dependent kinase (cdk)-1 and cdk-2 activity; and retinoblastoma protein (pRb), extracellular signal-regulated kinase (ERK) 1/2, and Akt phosphorylation.	2-Methoxyestradiol	78-82	cyclin dependent kinase 1	Homo sapiens	133-164
16912078-7	2006	A Thr to Glu mutant of the CDK1-type sites as well as other members of the nucleoplasmin family that lack the C-terminal nucleic-acid-binding region showed a greater mobility and/or faster recovery than wild-type B23.1, the longer variant.	Threonine	2-5	cyclin dependent kinase 1	Homo sapiens	27-31
16912078-7	2006	A Thr to Glu mutant of the CDK1-type sites as well as other members of the nucleoplasmin family that lack the C-terminal nucleic-acid-binding region showed a greater mobility and/or faster recovery than wild-type B23.1, the longer variant.	Glutamic Acid	9-12	cyclin dependent kinase 1	Homo sapiens	27-31
16807237-2	2006	Cdc25C activates Cdc2 for entry into mitosis by dephosphorylating Thr and Tyr at the site of inhibitory phosphorylation.	Threonine	66-69	cyclin dependent kinase 1	Homo sapiens	0-4
16807237-2	2006	Cdc25C activates Cdc2 for entry into mitosis by dephosphorylating Thr and Tyr at the site of inhibitory phosphorylation.	Tyrosine	74-77	cyclin dependent kinase 1	Homo sapiens	0-4
16807237-4	2006	Here we show that both Cdc25C and Cdc2 were down-regulated in wild-type HCT116 cells but not in p53-null, DNMT1-null or DNMT1and DNMT3b-null cells, upon p53 stabilization following doxorubicin-mediated DNA damage.	Doxorubicin	181-192	cyclin dependent kinase 1	Homo sapiens	23-27
16807237-5	2006	Furthermore, zebularine, a drug that selectively traps and depletes nuclear DNMT1 and DNMT3b, relieved p53-mediated repression of endogenous Cdc25C and Cdc2.	pyrimidin-2-one beta-ribofuranoside	13-23	cyclin dependent kinase 1	Homo sapiens	141-145
16807237-7	2006	Chromatin immunoprecipitation of doxorubicin treated wild-type HCT116 cells showed the presence of DNMT1, p53, H3K9me2, and the transcriptional repressor HDAC1 on the Cdc25C and Cdc2 promoters, suggesting their involvement as repressive complexes in Cdc25C and Cdc2 gene silencing.	Doxorubicin	33-44	cyclin dependent kinase 1	Homo sapiens	167-171
16807237-7	2006	Chromatin immunoprecipitation of doxorubicin treated wild-type HCT116 cells showed the presence of DNMT1, p53, H3K9me2, and the transcriptional repressor HDAC1 on the Cdc25C and Cdc2 promoters, suggesting their involvement as repressive complexes in Cdc25C and Cdc2 gene silencing.	Doxorubicin	33-44	cyclin dependent kinase 1	Homo sapiens	178-182
16628227-9	2006	This enhancement of apoptosis by amifostine was associated with activation of p53 and dephosphorylation of Cdc2 proteins.	Amifostine	33-43	cyclin dependent kinase 1	Homo sapiens	107-111
16628227-10	2006	Notably, olomoucine effectively prevented amifostine and/or Adp53-induced Cdc2 kinase activation and subsequent apoptosis.	olomoucine	9-19	cyclin dependent kinase 1	Homo sapiens	74-78
16628227-12	2006	In addition, it appears that Cdc2 kinase plays an important role in the induction of apoptosis by amifostine and Adp53.	Amifostine	98-108	cyclin dependent kinase 1	Homo sapiens	29-33
16928825-3	2006	Direct analysis of kinase activity in immune complex kinase assays revealed that docetaxel activated cyclin-dependent kinase (CDK) 1 (CDC2) and that bortezomib blocked this activation.	Docetaxel	81-90	cyclin dependent kinase 1	Homo sapiens	101-132
16908595-3	2006	Loss of mitosis in tumor cells is associated with marked reduction of cyclin-dependent kinase (CDK) 1 transcription and/or loss of its active form (CDK1-P-Thr(161)), which is coincident with up-regulation of CDKN1A, CDKN1B, and CDKN1C (p21, p27, and p57).	Threonine	155-158	cyclin dependent kinase 1	Homo sapiens	148-152
16840322-5	2006	Inactivation of cdk1 is through inhibitory Tyr(15) phosphorylation, with cells containing elevated levels of Wee1, the kinase responsible for inhibitory cdk1 phosphorylation.	Tyrosine	43-46	cyclin dependent kinase 1	Homo sapiens	16-20
16928825-3	2006	Direct analysis of kinase activity in immune complex kinase assays revealed that docetaxel activated cyclin-dependent kinase (CDK) 1 (CDC2) and that bortezomib blocked this activation.	Docetaxel	81-90	cyclin dependent kinase 1	Homo sapiens	134-138
16928825-4	2006	The effects of bortezomib were associated with accumulation of p21 and mimicked by chemical CDK inhibitors or by transfecting cells with a small interfering RNA construct specific for CDK1.	Bortezomib	15-25	cyclin dependent kinase 1	Homo sapiens	184-188
16928825-6	2006	Together, our data show that bortezomib interferes with docetaxel-induced apoptosis via a p21-dependent mechanism that is associated with CDK1 inhibition.	Bortezomib	29-39	cyclin dependent kinase 1	Homo sapiens	138-142
16928825-6	2006	Together, our data show that bortezomib interferes with docetaxel-induced apoptosis via a p21-dependent mechanism that is associated with CDK1 inhibition.	Docetaxel	56-65	cyclin dependent kinase 1	Homo sapiens	138-142
16571652-6	2006	PBOX-6 induces prometaphase arrest and causes an accumulation of cyclin B1 levels and activation of cyclin B1/CDK1 kinase in a manner similar to that of two representative antimicrotubule agents, nocodazole and paclitaxel.	PBOX-6	0-6	cyclin dependent kinase 1	Homo sapiens	110-114
16682184-0	2006	Identification of potent 5-pyrimidinyl-2-aminothiazole CDK4, 6 inhibitors with significant selectivity over CDK1, 2, 5, 7, and 9.	5-pyrimidinyl-2-aminothiazole	25-54	cyclin dependent kinase 1	Homo sapiens	108-112
16682184-1	2006	5-Pyrimidinyl-2-aminothiazole 1 was identified as an inhibitor of cyclin-dependent kinases (CDKs) by a screening of the Merck sample repository.	5-pyrimidinyl-2-aminothiazole	0-29	cyclin dependent kinase 1	Homo sapiens	92-96
16682184-2	2006	The introduction of a methyl group at the C-5 or C-6 position on the pyrimidine ring, directed toward the gate keeper residue of CDK4 (Phe93), led to significant enhancement of selectivity for CDK4 over other CDKs.	pyrimidine	69-79	cyclin dependent kinase 1	Homo sapiens	209-213
16888198-0	2006	Retinoic acid-induced human secretin gene expression in neuronal cells is mediated by cyclin-dependent kinase 1.	Tretinoin	0-13	cyclin dependent kinase 1	Homo sapiens	86-111
16818634-0	2006	Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation.	Dronabinol	0-27	cyclin dependent kinase 1	Homo sapiens	97-101
16818634-5	2006	In particular, THC arrests cells in G(2)-M via down-regulation of Cdc2, as suggested by the decreased sensitivity to THC acquired by Cdc2-overexpressing cells.	Dronabinol	15-18	cyclin dependent kinase 1	Homo sapiens	66-70
16818634-5	2006	In particular, THC arrests cells in G(2)-M via down-regulation of Cdc2, as suggested by the decreased sensitivity to THC acquired by Cdc2-overexpressing cells.	Dronabinol	15-18	cyclin dependent kinase 1	Homo sapiens	133-137
16818634-5	2006	In particular, THC arrests cells in G(2)-M via down-regulation of Cdc2, as suggested by the decreased sensitivity to THC acquired by Cdc2-overexpressing cells.	Dronabinol	117-120	cyclin dependent kinase 1	Homo sapiens	133-137
16614167-6	2006	Cyclin B/CDC2(CDK1) stabilization and caspase-3 activation persisted in arsenite-treated p53- cells consistent with MAAA/mitotic catastrophe.	arsenite	72-80	cyclin dependent kinase 1	Homo sapiens	9-13
16614167-6	2006	Cyclin B/CDC2(CDK1) stabilization and caspase-3 activation persisted in arsenite-treated p53- cells consistent with MAAA/mitotic catastrophe.	arsenite	72-80	cyclin dependent kinase 1	Homo sapiens	14-18
16614167-8	2006	WEE1 and p21CIP1/WAF1 inhibit cyclin B/CDC2 by CDC2 tyrosine-15 phosphorylation and direct binding, respectively.	Tyrosine	52-60	cyclin dependent kinase 1	Homo sapiens	39-43
16614167-8	2006	WEE1 and p21CIP1/WAF1 inhibit cyclin B/CDC2 by CDC2 tyrosine-15 phosphorylation and direct binding, respectively.	Tyrosine	52-60	cyclin dependent kinase 1	Homo sapiens	47-51
16783362-8	2006	In contrast with ATR-Seckel syndrome cells, MCPH1-mutant cells have low levels of Tyr 15-phosphorylated Cdk1 (pY15-Cdk1) in S and G2 phases, which correlates with an elevated frequency of G2-like cells displaying premature chromosome condensation (PCC).	Tyrosine	82-85	cyclin dependent kinase 1	Homo sapiens	104-108
16783362-8	2006	In contrast with ATR-Seckel syndrome cells, MCPH1-mutant cells have low levels of Tyr 15-phosphorylated Cdk1 (pY15-Cdk1) in S and G2 phases, which correlates with an elevated frequency of G2-like cells displaying premature chromosome condensation (PCC).	Tyrosine	82-85	cyclin dependent kinase 1	Homo sapiens	110-119
16446360-7	2006	Three serine/proline sites were identified for Cdk2 and Cdk1, and a unique site was phosphorylated by CK2.	Serine	6-12	cyclin dependent kinase 1	Homo sapiens	56-60
16614167-9	2006	CDC2-Y15-P was transiently elevated in arsenite-treated p53+ cells but persisted in p53- cells.	arsenite	39-47	cyclin dependent kinase 1	Homo sapiens	0-4
16317763-1	2006	Transcription of CDK1 is induced as cells re-enter the cell cycle from quiescence and these early cell cycle re-entry events have been modeled by okadaic acid treatment due to its activity on specific enhancer sequences in the human CDK1 promoter.	Okadaic Acid	146-158	cyclin dependent kinase 1	Homo sapiens	17-21
16317763-1	2006	Transcription of CDK1 is induced as cells re-enter the cell cycle from quiescence and these early cell cycle re-entry events have been modeled by okadaic acid treatment due to its activity on specific enhancer sequences in the human CDK1 promoter.	Okadaic Acid	146-158	cyclin dependent kinase 1	Homo sapiens	233-237
16551631-6	2006	Studies with PTHrP peptides 1-34 and 67-86, forskolin, and a PTH1 receptor (PTH1R)-specific siRNA showed that PTHrP regulates CDC2 and CDC25B, at least in part, via PTH1R in a cAMP-independent manner.	Cyclic AMP	176-180	cyclin dependent kinase 1	Homo sapiens	126-130
16054783-0	2006	In vitro maturation and fertilization of porcine oocytes after a 48 h culture in roscovitine, an inhibitor of p34cdc2/cyclin B kinase.	Roscovitine	81-92	cyclin dependent kinase 1	Homo sapiens	110-117
16639080-5	2006	We next demonstrate that downregulation of BRCA1 reduces the mitotic index and triggers premature cyclin B1 degradation and decrease in Cdk1 activity following paclitaxel treatment, suggesting that BRCA1 downregulation results in precocious inactivation of the spindle checkpoint.	Paclitaxel	160-170	cyclin dependent kinase 1	Homo sapiens	136-140
16307839-4	2006	Immunoblot assay showed that chalcone significantly decreased the expression of cyclin B1, cyclin A and Cdc2 protein, as well as increased the expression of p21 and p27 in a p53-independent manner, contributing to cell cycle arrest.	Chalcone	29-37	cyclin dependent kinase 1	Homo sapiens	104-108
16737765-8	2006	On the contrary, a decline of cyclin Bl, cdc2 and cdc25C mRNA and protein expression in SAS cells was found after exposure to sodium butyrate.	Butyric Acid	126-141	cyclin dependent kinase 1	Homo sapiens	41-45
16759374-4	2006	Recent work on Cdk2/Cdk4 double knockouts has indicated that these two Cdks are required to phosphorylate Rb during late embryogenesis.	Rubidium	106-108	cyclin dependent kinase 1	Homo sapiens	71-75
16546994-4	2006	Inhibitory phosphorylation at Thr(14) and Tyr(15) of the CDKs is modulated by complex regulatory mechanisms involving multiple kinases and phosphatases.	Threonine	30-33	cyclin dependent kinase 1	Homo sapiens	57-61
16546994-4	2006	Inhibitory phosphorylation at Thr(14) and Tyr(15) of the CDKs is modulated by complex regulatory mechanisms involving multiple kinases and phosphatases.	Tyrosine	42-45	cyclin dependent kinase 1	Homo sapiens	57-61
16669628-0	2006	Phosphorylation of STAT3 serine-727 by cyclin-dependent kinase 1 is critical for nocodazole-induced mitotic arrest.	Serine	25-31	cyclin dependent kinase 1	Homo sapiens	39-64
16669628-0	2006	Phosphorylation of STAT3 serine-727 by cyclin-dependent kinase 1 is critical for nocodazole-induced mitotic arrest.	Nocodazole	81-91	cyclin dependent kinase 1	Homo sapiens	39-64
16669628-5	2006	The nocodazole-induced STAT3 Ser-727 phosphorylation was reduced by selective inhibition of CDK1 phosphotransferase activity, and CDK1 could directly phosphorylate GST-STAT3 Ser-727 in vitro and co-immunoprecipitate with STAT3 in vivo.	Nocodazole	4-14	cyclin dependent kinase 1	Homo sapiens	92-96
16669628-5	2006	The nocodazole-induced STAT3 Ser-727 phosphorylation was reduced by selective inhibition of CDK1 phosphotransferase activity, and CDK1 could directly phosphorylate GST-STAT3 Ser-727 in vitro and co-immunoprecipitate with STAT3 in vivo.	Nocodazole	4-14	cyclin dependent kinase 1	Homo sapiens	130-134
16669628-5	2006	The nocodazole-induced STAT3 Ser-727 phosphorylation was reduced by selective inhibition of CDK1 phosphotransferase activity, and CDK1 could directly phosphorylate GST-STAT3 Ser-727 in vitro and co-immunoprecipitate with STAT3 in vivo.	Serine	29-32	cyclin dependent kinase 1	Homo sapiens	92-96
16669628-5	2006	The nocodazole-induced STAT3 Ser-727 phosphorylation was reduced by selective inhibition of CDK1 phosphotransferase activity, and CDK1 could directly phosphorylate GST-STAT3 Ser-727 in vitro and co-immunoprecipitate with STAT3 in vivo.	Serine	174-177	cyclin dependent kinase 1	Homo sapiens	92-96
16669628-5	2006	The nocodazole-induced STAT3 Ser-727 phosphorylation was reduced by selective inhibition of CDK1 phosphotransferase activity, and CDK1 could directly phosphorylate GST-STAT3 Ser-727 in vitro and co-immunoprecipitate with STAT3 in vivo.	Serine	174-177	cyclin dependent kinase 1	Homo sapiens	130-134
16770740-0	2006	Staurosporine-induced growth inhibition of glioma cells is accompanied by altered expression of cyclins, CDKs and CDK inhibitors.	Staurosporine	0-13	cyclin dependent kinase 1	Homo sapiens	105-109
16770740-4	2006	The levels of CDK2, CDC2, Cyclin A and Cyclin B proteins decreased, while the levels of CDK inhibitors viz., p21 and p27 were found to increase on staurosporine treatment.	Staurosporine	147-160	cyclin dependent kinase 1	Homo sapiens	20-24
16770740-5	2006	The mRNA levels of CDK2 and CDC2 genes were also found to decrease on staurosporine treatment.	Staurosporine	70-83	cyclin dependent kinase 1	Homo sapiens	28-32
16446360-7	2006	Three serine/proline sites were identified for Cdk2 and Cdk1, and a unique site was phosphorylated by CK2.	Proline	13-20	cyclin dependent kinase 1	Homo sapiens	56-60
16517539-4	2006	With arsenic trioxide exposure, both cell lines were arrested at the S-G2/M phase with the increase of cyclin B expression and CDK1 activity.	Arsenic Trioxide	5-21	cyclin dependent kinase 1	Homo sapiens	127-131
16481012-9	2006	As a consequence, tyrosine 15 (Y15) on Cdc2 remains hypophosphorylated, and there is a loss of the G2/M checkpoint.	Tyrosine	18-26	cyclin dependent kinase 1	Homo sapiens	39-43
16632252-3	2006	We show the oxindole inhibitor GW297361 elicits a Pho85-selective response in cells despite having a 20-fold greater biochemical potency for Cdk1 in vitro.	2-oxindole	12-20	cyclin dependent kinase 1	Homo sapiens	141-145
16632252-3	2006	We show the oxindole inhibitor GW297361 elicits a Pho85-selective response in cells despite having a 20-fold greater biochemical potency for Cdk1 in vitro.	gw297361	31-39	cyclin dependent kinase 1	Homo sapiens	141-145
16310807-6	2006	These results suggest that squamocin inhibits the proliferation of K562 cells via G2/M arrest in association with the induction of p21, p27 and the reduction of Cdk1 and Cdc25C kinase activities.	squamocin	27-36	cyclin dependent kinase 1	Homo sapiens	161-165
16690595-10	2006	The activity of cycline B1/Cdc2 kinase increased earlier but decayed rapidly in the presence of caffeine.	Caffeine	96-104	cyclin dependent kinase 1	Homo sapiens	27-31
16477379-5	2006	The sodium butyrate-induce cell cycle arrest was associated with the decrease of Cdc2, Cdk4 and cyclin A in BCBL-1 cells without altering the protein levels of p21(CIP1/WAF1).	Butyric Acid	4-19	cyclin dependent kinase 1	Homo sapiens	81-85
16533053-4	2006	Because cyclin B1 overexpression, induction of cdc2 phosphorylation, and its regulatory proteins wee1 and phospho-cdc25C (interphase and mitotic forms) by 2-ME(2) treatment correlated with the induction of apoptosis, growth arrest at the G2/M phase, and accumulation of the S phase, we reasoned that cyclin B1 and cdc2 phosphorylation and its upstream regulatory molecular networks may be associated with the ultimate impacts of 2-ME(2).	Mercaptoethanol	155-159	cyclin dependent kinase 1	Homo sapiens	47-51
16533053-4	2006	Because cyclin B1 overexpression, induction of cdc2 phosphorylation, and its regulatory proteins wee1 and phospho-cdc25C (interphase and mitotic forms) by 2-ME(2) treatment correlated with the induction of apoptosis, growth arrest at the G2/M phase, and accumulation of the S phase, we reasoned that cyclin B1 and cdc2 phosphorylation and its upstream regulatory molecular networks may be associated with the ultimate impacts of 2-ME(2).	Mercaptoethanol	155-159	cyclin dependent kinase 1	Homo sapiens	114-118
16533053-5	2006	Because phosphorylation of cdc2 and upregulation of wee1 by 2-ME(2) can be abolished by both extracellular receptor kinase (ERK) inhibitor (U0126) and c-Jun N-terminal kinase (JNK) inhibitor (SP600125), our studies indicate that the 2-ME(2)-induced upregulation of wee1 and subsequent cdc2 phosphorylation are mediated through mitogen-activated protein kinase (MAPK)-ERK-JNK signaling pathways.	Mercaptoethanol	60-64	cyclin dependent kinase 1	Homo sapiens	285-289
16533053-5	2006	Because phosphorylation of cdc2 and upregulation of wee1 by 2-ME(2) can be abolished by both extracellular receptor kinase (ERK) inhibitor (U0126) and c-Jun N-terminal kinase (JNK) inhibitor (SP600125), our studies indicate that the 2-ME(2)-induced upregulation of wee1 and subsequent cdc2 phosphorylation are mediated through mitogen-activated protein kinase (MAPK)-ERK-JNK signaling pathways.	U 0126	140-145	cyclin dependent kinase 1	Homo sapiens	27-31
16533053-5	2006	Because phosphorylation of cdc2 and upregulation of wee1 by 2-ME(2) can be abolished by both extracellular receptor kinase (ERK) inhibitor (U0126) and c-Jun N-terminal kinase (JNK) inhibitor (SP600125), our studies indicate that the 2-ME(2)-induced upregulation of wee1 and subsequent cdc2 phosphorylation are mediated through mitogen-activated protein kinase (MAPK)-ERK-JNK signaling pathways.	U 0126	140-145	cyclin dependent kinase 1	Homo sapiens	285-289
16533053-5	2006	Because phosphorylation of cdc2 and upregulation of wee1 by 2-ME(2) can be abolished by both extracellular receptor kinase (ERK) inhibitor (U0126) and c-Jun N-terminal kinase (JNK) inhibitor (SP600125), our studies indicate that the 2-ME(2)-induced upregulation of wee1 and subsequent cdc2 phosphorylation are mediated through mitogen-activated protein kinase (MAPK)-ERK-JNK signaling pathways.	pyrazolanthrone	192-200	cyclin dependent kinase 1	Homo sapiens	27-31
16533053-5	2006	Because phosphorylation of cdc2 and upregulation of wee1 by 2-ME(2) can be abolished by both extracellular receptor kinase (ERK) inhibitor (U0126) and c-Jun N-terminal kinase (JNK) inhibitor (SP600125), our studies indicate that the 2-ME(2)-induced upregulation of wee1 and subsequent cdc2 phosphorylation are mediated through mitogen-activated protein kinase (MAPK)-ERK-JNK signaling pathways.	Mercaptoethanol	233-237	cyclin dependent kinase 1	Homo sapiens	27-31
16619491-7	2006	The expression of cdc2 was not changed and phospho-cdc2 (Tyr 15) increased after 36-, 48- and 60-h treatment.	Tyrosine	57-60	cyclin dependent kinase 1	Homo sapiens	51-55
16407259-10	2006	Moreover, in vitro kinase assays using recombinant cdc2 kinase showed that RUNX2 was phosphorylated at Ser(451).	Serine	103-106	cyclin dependent kinase 1	Homo sapiens	51-55
16407259-11	2006	The cdc2 inhibitor roscovitine dose dependently inhibited in vivo RUNX2 DNA-binding activity during mitosis and the RUNX2 mutant S451A exhibited lower DNA-binding activity and reduced stimulation of anchorage-independent growth relative to wild type RUNX2.	Roscovitine	19-30	cyclin dependent kinase 1	Homo sapiens	4-8
16413651-6	2006	Western blot analysis revealed that arecoline induced cyclin Bl, Wee 1, and phosphorylated cdc2 protein levels whereas it declined p21 protein expression in KB cancer cells.	Arecoline	36-45	cyclin dependent kinase 1	Homo sapiens	91-95
16413651-7	2006	Nevertheless, arecoline induced p21, but decreased cdc2 and cyclin B1 protein levels in GK.	Arecoline	14-23	cyclin dependent kinase 1	Homo sapiens	51-55
16619512-6	2006	The berberine-induced G2/M-phase arrest in both examined cell lines was accompanied by increased levels of Wee1 and 14-3-3sigma, but decreased levels of Cdc25c, CDK1 and cyclin B1.	Berberine	4-13	cyclin dependent kinase 1	Homo sapiens	161-165
16619491-8	2006	In addition, protein phosphatase Cdc25C, which functions as a mitotic activator by dephosphorylation of Cdc2, decreased in a time-dependent manner after rocaglaol treatment.	rocaglaol	153-162	cyclin dependent kinase 1	Homo sapiens	33-37
16619491-9	2006	Taken together, these results suggest that rocaglaol is a potent anticancer drug that induces apoptosis of LNCaP cells through the mitochondrial pathway and its G2/M-phase cell cycle arrest is associated with the down-regulation of Cdc25C and the dephosphorylation of Cdc2.	rocaglaol	43-52	cyclin dependent kinase 1	Homo sapiens	232-236
16494969-4	2006	The histamine derivatives were less potent against CDK1/cyclin B and CDK5/p25 and totally inactive against GSK3alpha/beta.	Histamine	4-13	cyclin dependent kinase 1	Homo sapiens	51-55
16371510-5	2006	Using a phosphopeptide antibody, we find that a fraction of the cell tubulin is phosphorylated during mitosis, and this tubulin phosphorylation is inhibited by the Cdk1 inhibitor roscovitine.	Roscovitine	179-190	cyclin dependent kinase 1	Homo sapiens	164-168
16494969-2	2006	All the imino derivatives produced were tested for kinase inhibitory properties against three serine/threonine kinases, namely CDK1/cyclin B, CDK5/p25 and GSK3alpha/beta.	imino	8-13	cyclin dependent kinase 1	Homo sapiens	127-131
16338954-6	2006	The levels of phospho-CDC2 (threonine-161), CDC2, and cyclin B1 proteins were decreased, and the G2/M fractions were increased by arsenite.	Threonine	28-37	cyclin dependent kinase 1	Homo sapiens	22-26
15893418-5	2006	In HeLa cells, genistein inhibited CDK1 phosphorylation after irinotecan treatment.	Genistein	15-24	cyclin dependent kinase 1	Homo sapiens	35-39
15893418-5	2006	In HeLa cells, genistein inhibited CDK1 phosphorylation after irinotecan treatment.	Irinotecan	62-72	cyclin dependent kinase 1	Homo sapiens	35-39
16427064-9	2006	The phosphorylation was suppressed by treatment of cells with olomoucine of an inhibitor specific for cyclin dependent kinase (Cdk-1).	olomoucine	62-72	cyclin dependent kinase 1	Homo sapiens	127-132
16427064-10	2006	These results strongly suggest that heat stress activates Cdk-1 which phosphorylates Ser 37 on the stathmin molecule.	Serine	85-88	cyclin dependent kinase 1	Homo sapiens	58-63
16458118-3	2006	Flow cytometric analysis revealed that petrotetrayndiol A resulted in G2/M arrest in the cell cycle progression which was associated with a marked decrease in the protein expression of cyclin B1 and its activating partner Cdc2 with concomitant inductions of p21WAF1/CIP1.	petrotetrayndiol A	39-57	cyclin dependent kinase 1	Homo sapiens	222-226
16205633-5	2006	The G2-M arrest by silibinin and silymarin was associated with decreased levels of cyclin B1, cyclin A, pCdc2 (Tyr15), Cdc2, and an inhibition of Cdc2 kinase activity.	Silybin	19-28	cyclin dependent kinase 1	Homo sapiens	105-109
16205633-5	2006	The G2-M arrest by silibinin and silymarin was associated with decreased levels of cyclin B1, cyclin A, pCdc2 (Tyr15), Cdc2, and an inhibition of Cdc2 kinase activity.	Silybin	19-28	cyclin dependent kinase 1	Homo sapiens	119-123
16205633-5	2006	The G2-M arrest by silibinin and silymarin was associated with decreased levels of cyclin B1, cyclin A, pCdc2 (Tyr15), Cdc2, and an inhibition of Cdc2 kinase activity.	Silymarin	33-42	cyclin dependent kinase 1	Homo sapiens	105-109
16205633-5	2006	The G2-M arrest by silibinin and silymarin was associated with decreased levels of cyclin B1, cyclin A, pCdc2 (Tyr15), Cdc2, and an inhibition of Cdc2 kinase activity.	Silymarin	33-42	cyclin dependent kinase 1	Homo sapiens	119-123
16378098-2	2006	Here, we report that Cdk1 phosphorylates Thr 59 and Thr 388 on inner centromere protein (INCENP), which regulates the localization and kinase activity of Aurora-B from prophase to metaphase.	Threonine	41-44	cyclin dependent kinase 1	Homo sapiens	21-25
16106398-5	2006	Curcumin induced cell cycle arrest by reducing the expression of cyclin D1, Cdk1 and Cdc25C and apoptosis by reducing the expression of XIAP and survivin.	Curcumin	0-8	cyclin dependent kinase 1	Homo sapiens	76-80
16194618-0	2006	CDK1-cyclin B1 mediates the inhibition of proliferation induced by omega-3 fatty acids in MDA-MB-231 breast cancer cells.	Fatty Acids, Omega-3	67-86	cyclin dependent kinase 1	Homo sapiens	0-4
16194618-7	2006	The expression of cyclin A, cyclin B1 and cyclin-dependent kinase 1, the regulators required for the progression from G2 to mitosis, were all decreased by these fatty acids (western blot).	Fatty Acids	161-172	cyclin dependent kinase 1	Homo sapiens	42-67
16194618-9	2006	Upon omega-3 fatty acids treatment, cyclin B1 phosphorylation was inhibited and the expression of the cell division cycle 25C phosphatase, which dephosphorylates cyclin-dependent kinase 1, was decreased.	Fatty Acids, Omega-3	5-24	cyclin dependent kinase 1	Homo sapiens	162-187
16194618-10	2006	We conclude that the anti-proliferative effect of omega-3 fatty acids occurs via the regulation of the cyclin-dependent kinase 1-cyclin B1 complex.	Fatty Acids, Omega-3	50-69	cyclin dependent kinase 1	Homo sapiens	103-128
16378098-2	2006	Here, we report that Cdk1 phosphorylates Thr 59 and Thr 388 on inner centromere protein (INCENP), which regulates the localization and kinase activity of Aurora-B from prophase to metaphase.	Threonine	52-55	cyclin dependent kinase 1	Homo sapiens	21-25
16364210-6	2006	HP treatment also upregulated cell division cycle 2 (Cdc2) protein levels in the distal stump of the injured sciatic nerve.	Hematoporphyrins	0-2	cyclin dependent kinase 1	Homo sapiens	30-51
16205645-8	2006	Under this condition, the selenium effect on wild-type p53-activated fragment p21 (p21(WAF)), cyclin-dependent kinase (CDK)1 and CDK2 was also magnified in a manner consistent with enhanced cell growth arrest.	Selenium	26-34	cyclin dependent kinase 1	Homo sapiens	94-124
16440412-6	2006	In SNU-5 cells treated with 25-200 micromol/L berberine, G2/M cell cycle arrest was observed which was associated with a marked increment of the expression of p53, Wee1 and CDk1 proteins and decreased cyclin B.	Berberine	46-55	cyclin dependent kinase 1	Homo sapiens	173-177
16525614-4	2006	Treated with 220 micromol/L of genistein for 3 days, the expression level of CyclinB1, Cdk1, CyclinD1 and Cdk4 proteins was 58%, 64%, 46% and 43% of the control group, respectively (P&lt;0.01).	Genistein	31-40	cyclin dependent kinase 1	Homo sapiens	87-91
16364210-6	2006	HP treatment also upregulated cell division cycle 2 (Cdc2) protein levels in the distal stump of the injured sciatic nerve.	Hematoporphyrins	0-2	cyclin dependent kinase 1	Homo sapiens	53-57
16364210-10	2006	CONCLUSION: HP promotes the regeneration of injured sciatic axons by upregulating the synthesis of regeneration-related protein factors such as GAP-43 and Cdc2.	Hematoporphyrins	12-14	cyclin dependent kinase 1	Homo sapiens	155-159
31394642-6	2006	Futhermore, curcumin induced Wee1 expression and decreased the Cdc25c, cyclin B1 and CDK1 expressions, resulting in the induction of G2/M cell cycle arrest in the colo 205 cells.	Curcumin	12-20	cyclin dependent kinase 1	Homo sapiens	85-89
16397259-0	2006	AZ703, an imidazo[1,2-a]pyridine inhibitor of cyclin-dependent kinases 1 and 2, induces E2F-1-dependent apoptosis enhanced by depletion of cyclin-dependent kinase 9.	az703	0-5	cyclin dependent kinase 1	Homo sapiens	46-78
16397259-0	2006	AZ703, an imidazo[1,2-a]pyridine inhibitor of cyclin-dependent kinases 1 and 2, induces E2F-1-dependent apoptosis enhanced by depletion of cyclin-dependent kinase 9.	imidazo(1,2-a)pyridine	10-32	cyclin dependent kinase 1	Homo sapiens	46-78
16397259-2	2006	In vitro kinase assays showed that IC50 values for AZ703 against purified cyclin E/cdk2 and cyclin B/cdk1 were 34 and 29 nmol/L, respectively.	az703	51-56	cyclin dependent kinase 1	Homo sapiens	101-105
16397259-13	2006	AZ703-induced apoptosis in NCI-H1299 cells was enhanced by small interfering RNA-mediated depletion of cdk9, which caused reduced levels of Mcl-1 and XIAP, suggesting that cdk2, cdk1, and cdk9 represent a rational subset of family members for drug targeting.	az703	0-5	cyclin dependent kinase 1	Homo sapiens	178-182
16378246-2	2006	Here we performed cell cycle analyses on HEK cells stably expressing the human FP receptor and found that treatment with PGF(2alpha) delays mitosis and is associated with an increased expression of cyclin B1 and Cdc2 kinase activity.	Prostaglandins F	121-124	cyclin dependent kinase 1	Homo sapiens	212-216
31394642-8	2006	CONCLUSION: The results indicate that curcumin promoted the gene expression of Wee1 and inhibited that of Cdc25c, CDK1 and cyclin B1.	Curcumin	38-46	cyclin dependent kinase 1	Homo sapiens	114-118
17169946-7	2006	Recent work in cancer cytogenetics and on the modulation of radiation effects at the chromosome level using changes in gene expression associated with proteins or factors such as caffeine or amifostine treatment during G(2) to M-phase transition, reconfirmed the importance of G(2) chekpoint in determining radiosensitivity and of the cdk1/cyclin-B activity in the conversion of DNA damage into chromatid breaks.	Caffeine	179-187	cyclin dependent kinase 1	Homo sapiens	335-339
17169946-7	2006	Recent work in cancer cytogenetics and on the modulation of radiation effects at the chromosome level using changes in gene expression associated with proteins or factors such as caffeine or amifostine treatment during G(2) to M-phase transition, reconfirmed the importance of G(2) chekpoint in determining radiosensitivity and of the cdk1/cyclin-B activity in the conversion of DNA damage into chromatid breaks.	Amifostine	191-201	cyclin dependent kinase 1	Homo sapiens	335-339
15975956-0	2005	Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells.	Resveratrol	0-11	cyclin dependent kinase 1	Homo sapiens	19-23
16437677-5	2005	RESULTS: Pseudolaric acid B inhibited the growth of AGS cells in a time- and dose-dependent manner by arresting the cells at G(2)/M phase, which was accompanied with a decrease in the levels of cdc2.	pseudolaric acid B	9-27	cyclin dependent kinase 1	Homo sapiens	194-198
16316408-4	2005	TOPK-Thr-9, a cdk1/cyclin B target residue, was specifically phosphorylated during mitotic and meiotic phases, while TOPK-Thr-198, a key amino acid for the ATP pocket, was constantly phosphorylated irrespective of the cell cycle.	Threonine	5-8	cyclin dependent kinase 1	Homo sapiens	14-18
16317137-10	2005	The protein levels of cell division cycles (CDC)2 and CDC25C and the activity of CDC2 were also decreased in fisetin-treated cells (P &lt; 0.05).	fisetin	109-116	cyclin dependent kinase 1	Homo sapiens	44-49
16317137-10	2005	The protein levels of cell division cycles (CDC)2 and CDC25C and the activity of CDC2 were also decreased in fisetin-treated cells (P &lt; 0.05).	fisetin	109-116	cyclin dependent kinase 1	Homo sapiens	54-58
16176802-8	2005	Ponicidin-treated MCF-7 cells expressed reduced levels of cyclin B1, cdc2, transcription factor E2F, and Rb including phosphorylation at S780.	ponicidin	0-9	cyclin dependent kinase 1	Homo sapiens	69-73
16176802-11	2005	In MCF-10A cells, oridonin was more active than ponicidin in inhibiting the expression of cyclin B1, cdc2, S780-phosphorylated Rb, and E2F.	oridonin	18-26	cyclin dependent kinase 1	Homo sapiens	101-105
16176802-11	2005	In MCF-10A cells, oridonin was more active than ponicidin in inhibiting the expression of cyclin B1, cdc2, S780-phosphorylated Rb, and E2F.	ponicidin	48-57	cyclin dependent kinase 1	Homo sapiens	101-105
16250643-1	2005	Pyrazolopyridazine 1a was identified in a high-throughput screening carried out by BASF Bioresearch Corp. (Worcester, MA) as a potent inhibitor of CDK1/cyclin B and shown to have selectivity for the CDK family.	pyrazolopyridazine	0-18	cyclin dependent kinase 1	Homo sapiens	147-151
16250643-5	2005	As a result of the SAR study, monofuryl 1o has been synthesized and is one of the most active compounds against CDK1 of this series.	monofuryl 1o	30-42	cyclin dependent kinase 1	Homo sapiens	112-116
15975956-5	2005	The involvement of these molecules in resveratrol-induced S phase was also supported by the studies showing that addition of ATM/ATR inhibitor caffeine reverses resveratrol-caused activation of ATM/ATR-Chk1/2 as well as phosphorylation of Cdc25C, Cdc2 and H2A.X, and S phase arrest.	Caffeine	143-151	cyclin dependent kinase 1	Homo sapiens	239-243
15975956-5	2005	The involvement of these molecules in resveratrol-induced S phase was also supported by the studies showing that addition of ATM/ATR inhibitor caffeine reverses resveratrol-caused activation of ATM/ATR-Chk1/2 as well as phosphorylation of Cdc25C, Cdc2 and H2A.X, and S phase arrest.	Resveratrol	161-172	cyclin dependent kinase 1	Homo sapiens	239-243
15975956-7	2005	These findings for the first time identify that resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C pathway as a central mechanism for DNA damage and S phase arrest selectively in ovarian cancer cells, and provide a rationale for the potential efficacy of ATM/ATR agonists in the prevention and intervention of cancer.	Resveratrol	48-59	cyclin dependent kinase 1	Homo sapiens	67-71
15975956-2	2005	Here, we observed that resveratrol induces S phase arrest via Tyr15 phosphorylation of Cdc2 in human ovarian carcinoma Ovcar-3 cells.	Resveratrol	23-34	cyclin dependent kinase 1	Homo sapiens	87-91
15975956-5	2005	The involvement of these molecules in resveratrol-induced S phase was also supported by the studies showing that addition of ATM/ATR inhibitor caffeine reverses resveratrol-caused activation of ATM/ATR-Chk1/2 as well as phosphorylation of Cdc25C, Cdc2 and H2A.X, and S phase arrest.	Resveratrol	38-49	cyclin dependent kinase 1	Homo sapiens	239-243
16237118-4	2005	In this study, we show that: 1) the cdc2/CyB complex directly interacts with IP3R1 through Arg391, Arg441, and Arg871; 2) IP3R1 phosphorylation at Thr799 by the cdc2/CyB complex increases IP3 binding; and 3) cdc2/CyB phosphorylation increases IP3-gated Ca2+ release.	Inositol 1,4,5-Trisphosphate	77-80	cyclin dependent kinase 1	Homo sapiens	36-40
16049707-3	2005	In this study, we investigated the effects of quercetin on proliferation and cell cycle arrest by modulation of Cdc2/Cdk-1 protein in prostate cancer cells (PC-3).	Quercetin	46-55	cyclin dependent kinase 1	Homo sapiens	112-116
16049707-3	2005	In this study, we investigated the effects of quercetin on proliferation and cell cycle arrest by modulation of Cdc2/Cdk-1 protein in prostate cancer cells (PC-3).	Quercetin	46-55	cyclin dependent kinase 1	Homo sapiens	117-122
16049707-6	2005	Addition of quercetin led to substantial decrease in the expression of Cdc2/Cdk-1, cyclin B1 and phosphorylated pRb and increase in p21.	Quercetin	12-21	cyclin dependent kinase 1	Homo sapiens	71-75
16049707-6	2005	Addition of quercetin led to substantial decrease in the expression of Cdc2/Cdk-1, cyclin B1 and phosphorylated pRb and increase in p21.	Quercetin	12-21	cyclin dependent kinase 1	Homo sapiens	76-81
15887239-4	2005	High concentrations of Vitamin C caused transient S and G2 arrest in both cell lines by delaying the activation of the M-phase promoting factor (MPF), Cdc2/cyclin-B complex.	Ascorbic Acid	23-32	cyclin dependent kinase 1	Homo sapiens	151-155
15887239-5	2005	Although vitamin C did not inhibit the accumulation of cyclin-B1, it may have increased the level of Cdc2 inhibitory phosphorylation.	Ascorbic Acid	9-18	cyclin dependent kinase 1	Homo sapiens	101-105
16237118-4	2005	In this study, we show that: 1) the cdc2/CyB complex directly interacts with IP3R1 through Arg391, Arg441, and Arg871; 2) IP3R1 phosphorylation at Thr799 by the cdc2/CyB complex increases IP3 binding; and 3) cdc2/CyB phosphorylation increases IP3-gated Ca2+ release.	Inositol 1,4,5-Trisphosphate	77-80	cyclin dependent kinase 1	Homo sapiens	161-165
16237118-4	2005	In this study, we show that: 1) the cdc2/CyB complex directly interacts with IP3R1 through Arg391, Arg441, and Arg871; 2) IP3R1 phosphorylation at Thr799 by the cdc2/CyB complex increases IP3 binding; and 3) cdc2/CyB phosphorylation increases IP3-gated Ca2+ release.	Inositol 1,4,5-Trisphosphate	77-80	cyclin dependent kinase 1	Homo sapiens	161-165
16237118-4	2005	In this study, we show that: 1) the cdc2/CyB complex directly interacts with IP3R1 through Arg391, Arg441, and Arg871; 2) IP3R1 phosphorylation at Thr799 by the cdc2/CyB complex increases IP3 binding; and 3) cdc2/CyB phosphorylation increases IP3-gated Ca2+ release.	Inositol 1,4,5-Trisphosphate	122-125	cyclin dependent kinase 1	Homo sapiens	36-40
16237118-4	2005	In this study, we show that: 1) the cdc2/CyB complex directly interacts with IP3R1 through Arg391, Arg441, and Arg871; 2) IP3R1 phosphorylation at Thr799 by the cdc2/CyB complex increases IP3 binding; and 3) cdc2/CyB phosphorylation increases IP3-gated Ca2+ release.	Inositol 1,4,5-Trisphosphate	122-125	cyclin dependent kinase 1	Homo sapiens	161-165
16237118-4	2005	In this study, we show that: 1) the cdc2/CyB complex directly interacts with IP3R1 through Arg391, Arg441, and Arg871; 2) IP3R1 phosphorylation at Thr799 by the cdc2/CyB complex increases IP3 binding; and 3) cdc2/CyB phosphorylation increases IP3-gated Ca2+ release.	Inositol 1,4,5-Trisphosphate	122-125	cyclin dependent kinase 1	Homo sapiens	161-165
16237118-5	2005	Taken together, these results demonstrate that cdc2/CyB phosphorylation positively regulates IP3-gated Ca2+ signaling.	Inositol 1,4,5-Trisphosphate	93-96	cyclin dependent kinase 1	Homo sapiens	47-51
16118207-5	2005	Cytokinesis was also induced by the Cdk1-specific inhibitor purvalanol A but not by Cdk2/Cdk5- or Cdk4-specific inhibitors.	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	60-72	cyclin dependent kinase 1	Homo sapiens	36-40
16244663-2	2005	Here we show that high-affinity binding requires sequential phosphorylation by two kinases, CDK1 and GSK3, yielding pThr238, pThr234 and pSer230.	pthr238	116-123	cyclin dependent kinase 1	Homo sapiens	92-96
16244663-2	2005	Here we show that high-affinity binding requires sequential phosphorylation by two kinases, CDK1 and GSK3, yielding pThr238, pThr234 and pSer230.	pthr234	125-132	cyclin dependent kinase 1	Homo sapiens	92-96
16244663-2	2005	Here we show that high-affinity binding requires sequential phosphorylation by two kinases, CDK1 and GSK3, yielding pThr238, pThr234 and pSer230.	pser230	137-144	cyclin dependent kinase 1	Homo sapiens	92-96
16151644-3	2005	Etoposide activated p38, inhibited the G2/M transition with the persistent inhibitory phosphorylation of Cdc2 on Tyr15, and caused apoptosis of Daudi cells.	Etoposide	0-9	cyclin dependent kinase 1	Homo sapiens	105-109
16007142-0	2005	Sodium butyrate sensitizes human glioma cells to TRAIL-mediated apoptosis through inhibition of Cdc2 and the subsequent downregulation of survivin and XIAP.	Butyric Acid	0-15	cyclin dependent kinase 1	Homo sapiens	96-100
16007142-6	2005	Furthermore, the kinase activities of Cdc2 and Cdk2 were significantly decreased following sodium butyrate treatment, accompanying downregulation of cyclin A and cyclin B, as well as upregulation of p21.	Butyric Acid	91-106	cyclin dependent kinase 1	Homo sapiens	38-42
16007142-7	2005	Forced expression of Cdc2 plus cyclin B, but not Cdk2 plus cyclin A, attenuated sodium butyrate/TRAIL-induced apoptosis, overriding sodium butyrate-mediated downregulation of survivin and XIAP.	Butyric Acid	80-95	cyclin dependent kinase 1	Homo sapiens	21-25
16007142-7	2005	Forced expression of Cdc2 plus cyclin B, but not Cdk2 plus cyclin A, attenuated sodium butyrate/TRAIL-induced apoptosis, overriding sodium butyrate-mediated downregulation of survivin and XIAP.	Butyric Acid	132-147	cyclin dependent kinase 1	Homo sapiens	21-25
16007142-8	2005	Therefore, Cdc2-mediated downregulation of survivin and XIAP by sodium butyrate may contribute to the recovery of TRAIL sensitivity in glioma cells.	Butyric Acid	64-79	cyclin dependent kinase 1	Homo sapiens	11-15
16151644-5	2005	SB203580, a specific inhibitor of p38alpha and p38beta, similarly reduced the inhibitory phosphorylation of Cdc2 as well as G2/M arrest and augmented apoptosis of Daudi cells treated with etoposide.	SB 203580	0-8	cyclin dependent kinase 1	Homo sapiens	108-112
16151644-5	2005	SB203580, a specific inhibitor of p38alpha and p38beta, similarly reduced the inhibitory phosphorylation of Cdc2 as well as G2/M arrest and augmented apoptosis of Daudi cells treated with etoposide.	Etoposide	188-197	cyclin dependent kinase 1	Homo sapiens	108-112
16151644-6	2005	These results suggest that p38 plays a role in G2/M checkpoint activation through induction of the persistent inhibitory phosphorylation of Cdc2 and, thereby, inhibits apoptosis of Daudi cells treated with etoposide.	Etoposide	206-215	cyclin dependent kinase 1	Homo sapiens	140-144
16181779-13	2005	In conclusion, these variolins are a new class of CDK inhibitors that activate apoptosis in a p53-independent fashion and thus they may be effective against tumours with p53 mutations or deletions.	variolins	21-30	cyclin dependent kinase 1	Homo sapiens	50-53
15951378-2	2005	Roscovitine, a potent inhibitor of cyclin-dependent kinases 1, 2, and 5, has recently been reported to slow the deactivation of P/Q-type calcium channels (CaV2.1).	Roscovitine	0-11	cyclin dependent kinase 1	Homo sapiens	35-71
16142332-5	2005	G2/M arrest, reduction in p21(Cip1/Waf1) and inactivation of cellular cdc-2 activity were seen in both SarCNU-treated HK-1 and CNE-2 cells.	2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamide	103-109	cyclin dependent kinase 1	Homo sapiens	70-75
16142332-8	2005	In contrast to HK-1 cells, decrease in total cdc-2 but increase in phosphorylated cdc-2 at Tyr15, cyclin B1 and Wee1 was observed in CNE-2 cells treated with SarCNU.	2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamide	158-164	cyclin dependent kinase 1	Homo sapiens	45-50
16142332-8	2005	In contrast to HK-1 cells, decrease in total cdc-2 but increase in phosphorylated cdc-2 at Tyr15, cyclin B1 and Wee1 was observed in CNE-2 cells treated with SarCNU.	2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamide	158-164	cyclin dependent kinase 1	Homo sapiens	82-87
16081423-9	2005	To confirm that the sequence surrounding serine 1237 was responsible for the differential regulation by Cdk1 and Cdk2, we replaced 4 amino acids flanking the phosphorylation site to mimic a known Cdk2 phosphorylation site present in the Cdc6 protein.	Serine	41-47	cyclin dependent kinase 1	Homo sapiens	104-108
15940258-3	2005	The DATS-induced cell cycle arrest in PC-3 cells was associated with increased Tyr(15) phosphorylation of cyclin-dependent kinase 1 (Cdk 1) and inhibition of Cdk 1/cyclinB 1 kinase activity.	Tyrosine	79-82	cyclin dependent kinase 1	Homo sapiens	106-131
15940258-3	2005	The DATS-induced cell cycle arrest in PC-3 cells was associated with increased Tyr(15) phosphorylation of cyclin-dependent kinase 1 (Cdk 1) and inhibition of Cdk 1/cyclinB 1 kinase activity.	Tyrosine	79-82	cyclin dependent kinase 1	Homo sapiens	133-138
16036217-6	2005	Our results demonstrate that differential regulation of Cdc2 and Cdk2 activity by different doses of doxorubicin may contribute to the induction of two distinct modes of cell death in hepatoma cells, either apoptosis or cell death through mitotic catastrophe.	Doxorubicin	101-112	cyclin dependent kinase 1	Homo sapiens	56-60
16081423-4	2005	CDP/Cux p110 makes stable interactions with DNA during S phase but is inhibited in G2 following the phosphorylation of serine 1237 by cyclin A/Cdk1.	Serine	119-125	cyclin dependent kinase 1	Homo sapiens	143-147
16085347-8	2005	However, CAPE (1-10 microM) treatment of AsT-HOS cells inhibited cell growth, induced cell cycle G2/M arrest, and triggered apoptosis, accompanied by changes in cytokine gene expression, as well as decreases in cyclin B1 and cdc2 abundance.	caffeic acid phenethyl ester	9-13	cyclin dependent kinase 1	Homo sapiens	225-229
16036217-0	2005	Cdc2 and Cdk2 play critical roles in low dose doxorubicin-induced cell death through mitotic catastrophe but not in high dose doxorubicin-induced apoptosis.	Doxorubicin	46-57	cyclin dependent kinase 1	Homo sapiens	0-4
16036217-2	2005	In this study, we investigated the role of Cdc2 and Cdk2 kinase in the regulation of the two modes of cell death induced by doxorubicin.	Doxorubicin	124-135	cyclin dependent kinase 1	Homo sapiens	43-47
16036217-3	2005	During HD doxorubicin-induced apoptosis, the histone H1-associated activities of Cdc2 and Cdk2 both progressively declined in parallel with reductions in cyclin A and cyclin B protein levels.	Doxorubicin	10-21	cyclin dependent kinase 1	Homo sapiens	81-85
16036217-4	2005	In contrast, during LD doxorubicin-induced cell death through mitotic catastrophe, the Cdc2 and Cdk2 kinases were transiently activated 1 day post-treatment, with similar changes seen in the protein levels of cyclin A, cyclin B, and Cdc2.	Doxorubicin	23-34	cyclin dependent kinase 1	Homo sapiens	87-91
16036217-4	2005	In contrast, during LD doxorubicin-induced cell death through mitotic catastrophe, the Cdc2 and Cdk2 kinases were transiently activated 1 day post-treatment, with similar changes seen in the protein levels of cyclin A, cyclin B, and Cdc2.	Doxorubicin	23-34	cyclin dependent kinase 1	Homo sapiens	233-237
16036217-5	2005	Treatment with roscovitine, a specific inhibitor of Cdc2 and Cdk2, significantly blocked LD doxorubicin-induced mitotic catastrophe and cell death, but did not affect HD doxorubicin-induced apoptosis in Huh-7, SNU-398, and SNU-449 hepatoma cell lines.	Roscovitine	15-26	cyclin dependent kinase 1	Homo sapiens	52-56
16438845-9	2005	Z-ajoene also caused an increase in cyclin B1 accumulation and a decrease of p34(cdc2) expression.	(Z)-Ajoene	0-8	cyclin dependent kinase 1	Homo sapiens	81-85
16123242-5	2005	In NT embryos treated with caffeine, the activity of p34(cdc2) kinase was significantly (P &lt; 0.05) higher than in those without caffeine at 3 h post-injection.	Caffeine	27-35	cyclin dependent kinase 1	Homo sapiens	57-61
16024531-5	2005	Western blot analyses indicated that oxaliplatin decreased mitosis-commencing protein cdc2 and anti-apoptotic proteins, phospho-Bcl(2) and Bcl-xl in the three colon cancer cells tested.	Oxaliplatin	37-48	cyclin dependent kinase 1	Homo sapiens	86-90
15955820-3	2005	We demonstrated first that IE63 was phosphorylated on Ser-224 in vitro by CDK1 and CDK5 but not by CDK2, CDK7, or CDK9.	Serine	54-57	cyclin dependent kinase 1	Homo sapiens	74-78
15955820-4	2005	Furthermore, by using roscovitine and CDK1 inhibitor III (CiIII), we showed that CDK1 phosphorylated IE63 on Ser-224 in vivo.	Roscovitine	22-33	cyclin dependent kinase 1	Homo sapiens	81-85
15955820-4	2005	Furthermore, by using roscovitine and CDK1 inhibitor III (CiIII), we showed that CDK1 phosphorylated IE63 on Ser-224 in vivo.	Serine	109-112	cyclin dependent kinase 1	Homo sapiens	38-42
15955820-4	2005	Furthermore, by using roscovitine and CDK1 inhibitor III (CiIII), we showed that CDK1 phosphorylated IE63 on Ser-224 in vivo.	Serine	109-112	cyclin dependent kinase 1	Homo sapiens	81-85
15985436-3	2005	At the G2/M transition, p73 is phosphorylated at Thr-86 by the p34cdc2/cyclin B complex; this is associated with its exclusion from condensed chromosomes and loss of DNA binding and transcriptional activation ability.	Threonine	49-52	cyclin dependent kinase 1	Homo sapiens	63-70
15961392-1	2005	We have shown previously that diallyl trisulfide (DATS), a constituent of processed garlic, inhibits proliferation of PC-3 and DU145 human prostate cancer cells by causing G(2)-M phase cell cycle arrest in association with inhibition of cyclin-dependent kinase 1 activity and hyperphosphorylation of Cdc25C at Ser(216).	diallyl trisulfide	30-48	cyclin dependent kinase 1	Homo sapiens	237-262
15961392-1	2005	We have shown previously that diallyl trisulfide (DATS), a constituent of processed garlic, inhibits proliferation of PC-3 and DU145 human prostate cancer cells by causing G(2)-M phase cell cycle arrest in association with inhibition of cyclin-dependent kinase 1 activity and hyperphosphorylation of Cdc25C at Ser(216).	diallyl trisulfide	50-54	cyclin dependent kinase 1	Homo sapiens	237-262
16024531-6	2005	Since cdc2 stabilizes survivin, a putative IAP (inhibitor of apoptosis) family member, through phosphorylation of Thr34, we examined the level of survivin and found a marked decrease due to oxaliplatin.	Oxaliplatin	190-201	cyclin dependent kinase 1	Homo sapiens	6-10
15964826-4	2005	Inactivation of Akt by chemotherapeutic drugs or the phosphatidylinositide-3-OH kinase inhibitor LY294002 induced G2/M arrest together with the inhibitory phosphorylation of Cdc2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	cyclin dependent kinase 1	Homo sapiens	174-178
15897904-7	2005	Taken together, our data suggest that PTX-increases the functional level of eIF-4E by promoting the hyperphosphorylation and release of 4E-BP1 through a cdk1-dependent mechanism.	Paclitaxel	38-41	cyclin dependent kinase 1	Homo sapiens	153-157
15688426-10	2005	Chk1 inhibition facilitates paclitaxel-induced M-phase entry by activation of Cdc2 kinase and accumulation of cyclin B1, the required cofactor for Cdc2 kinase activity.	Paclitaxel	28-38	cyclin dependent kinase 1	Homo sapiens	78-82
15688426-10	2005	Chk1 inhibition facilitates paclitaxel-induced M-phase entry by activation of Cdc2 kinase and accumulation of cyclin B1, the required cofactor for Cdc2 kinase activity.	Paclitaxel	28-38	cyclin dependent kinase 1	Homo sapiens	147-151
15888452-7	2005	Inhibition of Cdc2 activity with roscovitine in mitotic cells restored ERK activation by EGF and PMA.	Roscovitine	33-44	cyclin dependent kinase 1	Homo sapiens	14-18
16024801-6	2005	This event is associated with the downregulation of the kinase activity of the Cdc2/cyclin B1 complex and the dephosphorylation of the threonine 161 on the Cdc2 subunit.	Threonine	135-144	cyclin dependent kinase 1	Homo sapiens	79-83
16024801-6	2005	This event is associated with the downregulation of the kinase activity of the Cdc2/cyclin B1 complex and the dephosphorylation of the threonine 161 on the Cdc2 subunit.	Threonine	135-144	cyclin dependent kinase 1	Homo sapiens	156-160
15897904-0	2005	Paclitaxel induces the phosphorylation of the eukaryotic translation initiation factor 4E-binding protein 1 through a Cdk1-dependent mechanism.	Paclitaxel	0-10	cyclin dependent kinase 1	Homo sapiens	118-122
15870882-6	2005	In flow cytometric analysis, G2-M cell cycle arrest was specifically observed in GB-d1 cells with MGMT-/hMLH1+ and expression of cyclin A and Cdc2 in GB-d1 cells was significantly reduced by MNU treatment, but not observed in KMG-C cells with MGMT+/hMLH1+.	Methylnitrosourea	191-194	cyclin dependent kinase 1	Homo sapiens	142-146
15856029-8	2005	Kinases assays reveal that cdk1, cdk2 and cdk4 activity are suppressed in AGN193198-treated cells.	AGN193198	74-83	cyclin dependent kinase 1	Homo sapiens	27-31
15930307-4	2005	Temozolomide-treated control cells activated the DNA damage signal transducers Chk1, Chk2, and p38, leading to Cdc25C and Cdc2 inactivation, prolonged G2 arrest, and loss of clonagenicity by a combination of senescence and mitotic catastrophe.	Temozolomide	0-12	cyclin dependent kinase 1	Homo sapiens	111-115
15930307-5	2005	Temozolomide-treated cells induced to overexpress Akt, however, exhibited significantly less drug-induced Cdc25C/Cdc2 inactivation and less G2 arrest.	Temozolomide	0-12	cyclin dependent kinase 1	Homo sapiens	106-110
16020661-5	2005	Transfection of a dominant-negative (DN)-CDK2 evoked resistance to paclitaxel by preventing cellular progression to mitosis through loss of CDK1 activity.	Paclitaxel	67-77	cyclin dependent kinase 1	Homo sapiens	140-144
15870882-9	2005	In conclusion, MNU suppressed cell proliferation of MGMT-/hMLH1+ gallbladder carcinoma cells by arresting the cell cycle at the G2-M phase, accompanied by down-regulation of cyclin A and Cdc2.	Methylnitrosourea	15-18	cyclin dependent kinase 1	Homo sapiens	187-191
15790566-6	2005	Furthermore, we found that Cdk1 activity was required for etoposide-induced apoptosis of HeLa cells.	Etoposide	58-67	cyclin dependent kinase 1	Homo sapiens	27-31
15890005-3	2005	Prx I and Prx II become inactivated when phosphorylated on Thr(90) by cyclin B-dependent kinase Cdc2.	Threonine	59-62	cyclin dependent kinase 1	Homo sapiens	96-100
15735676-8	2005	Importantly, CT-32615 inhibits growth of DHL-4 cells in a time- and dose-dependent fashion: a transient G2/M cell cycle arrest induced by CT-32615 is mediated via downregulation of cdc25c and cdc2.	UNII-3SI12BK34I	13-21	cyclin dependent kinase 1	Homo sapiens	181-185
15826604-3	2005	Treatment of Jurkat T cells with QBS increased the levels of cyclin B1 as well as phosphorylated-cdc2, which was accompanied by reduced activity of cdc2 kinase, suggesting that QBS may induce cell cycle arrest at G2 phase.	2-Amino-N-quinolin-8-yl-benzenesulfonamide	33-36	cyclin dependent kinase 1	Homo sapiens	97-101
15826604-3	2005	Treatment of Jurkat T cells with QBS increased the levels of cyclin B1 as well as phosphorylated-cdc2, which was accompanied by reduced activity of cdc2 kinase, suggesting that QBS may induce cell cycle arrest at G2 phase.	2-Amino-N-quinolin-8-yl-benzenesulfonamide	33-36	cyclin dependent kinase 1	Homo sapiens	148-152
15735676-8	2005	Importantly, CT-32615 inhibits growth of DHL-4 cells in a time- and dose-dependent fashion: a transient G2/M cell cycle arrest induced by CT-32615 is mediated via downregulation of cdc25c and cdc2.	UNII-3SI12BK34I	138-146	cyclin dependent kinase 1	Homo sapiens	181-185
15771433-3	2005	Attempts to optimize a cyclin-dependent kinase-1 (CDK1) inhibitor by using palladium-catalyzed C-C bond, C-N bond formation reactions to assemble diverse biheteroaryl molecules led to the unexpected discovery of a pyrazine-pyridine biheteroaryl as a novel series of potent VEGFR-2 inhibitors.	biheteroaryl	154-166	cyclin dependent kinase 1	Homo sapiens	23-48
15626723-8	2005	Asiatic acid was likely to confine the breast cancer cells in the S-G2/M phase mainly through the p38 pathway, because both SB203580 and p38 small interfering RNA (siRNA) inhibition significantly attenuated the accumulation of inactive phospho-Cdc2 and phospho-Cdc25C proteins and the cell numbers of S-G2/M phase.	asiatic acid	0-12	cyclin dependent kinase 1	Homo sapiens	244-248
15808450-1	2005	A series of aminobenzimidazole-substituted pyrimidines were synthesized and evaluated for biochemical activity against CDK1.	aminobenzimidazole-substituted pyrimidines	12-54	cyclin dependent kinase 1	Homo sapiens	119-123
15868412-7	2005	Finally, the combination of beta-elemene and cisplatin was found to increase the phosphorylation of Cdc2 and Cdc25C, which leads to a reduction in Cdc2-cyclin B1 activity.	beta-elemene	28-40	cyclin dependent kinase 1	Homo sapiens	100-104
15868412-7	2005	Finally, the combination of beta-elemene and cisplatin was found to increase the phosphorylation of Cdc2 and Cdc25C, which leads to a reduction in Cdc2-cyclin B1 activity.	beta-elemene	28-40	cyclin dependent kinase 1	Homo sapiens	109-113
15868412-7	2005	Finally, the combination of beta-elemene and cisplatin was found to increase the phosphorylation of Cdc2 and Cdc25C, which leads to a reduction in Cdc2-cyclin B1 activity.	Cisplatin	45-54	cyclin dependent kinase 1	Homo sapiens	100-104
15868412-7	2005	Finally, the combination of beta-elemene and cisplatin was found to increase the phosphorylation of Cdc2 and Cdc25C, which leads to a reduction in Cdc2-cyclin B1 activity.	Cisplatin	45-54	cyclin dependent kinase 1	Homo sapiens	109-113
15702922-1	2005	We describe a refined homology model of a CDK1/cyclin B complex that was previously used for the structure-based optimization of the Paullone class of inhibitors.	paullone	133-141	cyclin dependent kinase 1	Homo sapiens	42-46
15702922-6	2005	Our examination of the CDK1/cyclin B model includes a comparison with the CDK2/cyclin A crystal structure in the PSTAIRE interface region, connecting portions to the ATP binding domain, as well as the ATP binding site itself.	Adenosine Triphosphate	166-169	cyclin dependent kinase 1	Homo sapiens	23-27
15626723-4	2005	Asiatic acid also reduced Cdc2 function by increasing the association of p21/WAF1/Cdc2 complex and the level of inactivated phospho-Cdc2 and phospho-Cdc25C.	asiatic acid	0-12	cyclin dependent kinase 1	Homo sapiens	26-30
15626723-4	2005	Asiatic acid also reduced Cdc2 function by increasing the association of p21/WAF1/Cdc2 complex and the level of inactivated phospho-Cdc2 and phospho-Cdc25C.	asiatic acid	0-12	cyclin dependent kinase 1	Homo sapiens	82-86
15626723-4	2005	Asiatic acid also reduced Cdc2 function by increasing the association of p21/WAF1/Cdc2 complex and the level of inactivated phospho-Cdc2 and phospho-Cdc25C.	asiatic acid	0-12	cyclin dependent kinase 1	Homo sapiens	82-86
15771433-3	2005	Attempts to optimize a cyclin-dependent kinase-1 (CDK1) inhibitor by using palladium-catalyzed C-C bond, C-N bond formation reactions to assemble diverse biheteroaryl molecules led to the unexpected discovery of a pyrazine-pyridine biheteroaryl as a novel series of potent VEGFR-2 inhibitors.	Palladium	75-84	cyclin dependent kinase 1	Homo sapiens	23-48
15771433-3	2005	Attempts to optimize a cyclin-dependent kinase-1 (CDK1) inhibitor by using palladium-catalyzed C-C bond, C-N bond formation reactions to assemble diverse biheteroaryl molecules led to the unexpected discovery of a pyrazine-pyridine biheteroaryl as a novel series of potent VEGFR-2 inhibitors.	Palladium	75-84	cyclin dependent kinase 1	Homo sapiens	50-54
15771433-3	2005	Attempts to optimize a cyclin-dependent kinase-1 (CDK1) inhibitor by using palladium-catalyzed C-C bond, C-N bond formation reactions to assemble diverse biheteroaryl molecules led to the unexpected discovery of a pyrazine-pyridine biheteroaryl as a novel series of potent VEGFR-2 inhibitors.	Carbon	50-51	cyclin dependent kinase 1	Homo sapiens	23-48
15771433-3	2005	Attempts to optimize a cyclin-dependent kinase-1 (CDK1) inhibitor by using palladium-catalyzed C-C bond, C-N bond formation reactions to assemble diverse biheteroaryl molecules led to the unexpected discovery of a pyrazine-pyridine biheteroaryl as a novel series of potent VEGFR-2 inhibitors.	Nitrogen	107-108	cyclin dependent kinase 1	Homo sapiens	23-48
15771433-3	2005	Attempts to optimize a cyclin-dependent kinase-1 (CDK1) inhibitor by using palladium-catalyzed C-C bond, C-N bond formation reactions to assemble diverse biheteroaryl molecules led to the unexpected discovery of a pyrazine-pyridine biheteroaryl as a novel series of potent VEGFR-2 inhibitors.	Nitrogen	107-108	cyclin dependent kinase 1	Homo sapiens	50-54
15771433-3	2005	Attempts to optimize a cyclin-dependent kinase-1 (CDK1) inhibitor by using palladium-catalyzed C-C bond, C-N bond formation reactions to assemble diverse biheteroaryl molecules led to the unexpected discovery of a pyrazine-pyridine biheteroaryl as a novel series of potent VEGFR-2 inhibitors.	biheteroaryl	154-166	cyclin dependent kinase 1	Homo sapiens	50-54
15771433-3	2005	Attempts to optimize a cyclin-dependent kinase-1 (CDK1) inhibitor by using palladium-catalyzed C-C bond, C-N bond formation reactions to assemble diverse biheteroaryl molecules led to the unexpected discovery of a pyrazine-pyridine biheteroaryl as a novel series of potent VEGFR-2 inhibitors.	pyrazine-pyridine biheteroaryl	214-244	cyclin dependent kinase 1	Homo sapiens	23-48
15771433-3	2005	Attempts to optimize a cyclin-dependent kinase-1 (CDK1) inhibitor by using palladium-catalyzed C-C bond, C-N bond formation reactions to assemble diverse biheteroaryl molecules led to the unexpected discovery of a pyrazine-pyridine biheteroaryl as a novel series of potent VEGFR-2 inhibitors.	pyrazine-pyridine biheteroaryl	214-244	cyclin dependent kinase 1	Homo sapiens	50-54
15590651-9	2005	Interestingly, tubulin polymerization and cyclin-dependent kinase Cdc2 activation induced by Taxol was not affected by curcumin.	Paclitaxel	93-98	cyclin dependent kinase 1	Homo sapiens	66-70
15701524-3	2005	The use of the cyclin-dependent protein kinase inhibitor roscovitine and immunodepletion studies with an anti-cyclin B1 antibody established that Cdk1 was responsible for the phosphorylation of the carboxy-terminal extremity of p54nrb whereas a different kinase appeared to be involved in the generation of CC-3 epitope(s) in the amino-terminal moiety of the protein.	Roscovitine	57-68	cyclin dependent kinase 1	Homo sapiens	146-150
15780175-2	2005	In both human and fission yeast (Schizosaccharomyces pombe) cells, the activity of Cdc2 is regulated in part by the phosphorylation status of tyrosine 15 (Tyr15) on Cdc2, which is phosphorylated by Wee1 kinase during late G2 and is rapidly dephosphorylated by the Cdc25 tyrosine phosphatase to trigger entry into mitosis.	Tyrosine	142-150	cyclin dependent kinase 1	Homo sapiens	83-87
15780175-2	2005	In both human and fission yeast (Schizosaccharomyces pombe) cells, the activity of Cdc2 is regulated in part by the phosphorylation status of tyrosine 15 (Tyr15) on Cdc2, which is phosphorylated by Wee1 kinase during late G2 and is rapidly dephosphorylated by the Cdc25 tyrosine phosphatase to trigger entry into mitosis.	Tyrosine	142-150	cyclin dependent kinase 1	Homo sapiens	165-169
15674326-4	2005	Erythropoietin or IL-3 significantly enhanced etoposide-induced activation-specific phosphorylation of Chk1, a checkpoint kinase that inhibits Cdc2 activation by Cdc25 phosphatases, and led to the inhibition of Cdc2 kinase activity with the persistent inhibitory phosphorylation on Tyr15.	Etoposide	46-55	cyclin dependent kinase 1	Homo sapiens	143-147
15674326-4	2005	Erythropoietin or IL-3 significantly enhanced etoposide-induced activation-specific phosphorylation of Chk1, a checkpoint kinase that inhibits Cdc2 activation by Cdc25 phosphatases, and led to the inhibition of Cdc2 kinase activity with the persistent inhibitory phosphorylation on Tyr15.	Etoposide	46-55	cyclin dependent kinase 1	Homo sapiens	162-166
15674326-5	2005	The inhibitory Cdc2 phosphorylation and G2/M block by etoposide were enhanced or inhibited by overexpression of Chk1 or by the specific Chk1 inhibitor SB218078, respectively.	Etoposide	54-63	cyclin dependent kinase 1	Homo sapiens	15-19
15674326-5	2005	The inhibitory Cdc2 phosphorylation and G2/M block by etoposide were enhanced or inhibited by overexpression of Chk1 or by the specific Chk1 inhibitor SB218078, respectively.	SB 218078	151-159	cyclin dependent kinase 1	Homo sapiens	15-19
15674326-8	2005	These results indicate that hematopoietic cytokines protect etoposide-treated cells from DNA damage-induced apoptosis by promoting, through the PI3K/Akt/GSK3 signaling pathway, G2/M checkpoint that is dependent on Chk1-mediated inhibition of Cdc2.	Etoposide	60-69	cyclin dependent kinase 1	Homo sapiens	242-246
15788687-11	2005	Additionally, transfection of Cdc2 with a mutation at Ser(39) to Ala, which is the CK2 phosphorylation site, partially inhibits cell cycle progression in G(1) to G(2) phase following 6-TG treatment.	Thioguanine	183-187	cyclin dependent kinase 1	Homo sapiens	30-34
15696597-4	2005	The novel 2-cyanoethylalsterpaullone (7) proved to be the most potent paullone described so far, exhibiting inhibitory concentrations for CDK1/ cyclin B and GSK-3beta in the picomolar range.	2-cyanoethylalsterpaullone	10-36	cyclin dependent kinase 1	Homo sapiens	138-142
15696597-4	2005	The novel 2-cyanoethylalsterpaullone (7) proved to be the most potent paullone described so far, exhibiting inhibitory concentrations for CDK1/ cyclin B and GSK-3beta in the picomolar range.	paullone	28-36	cyclin dependent kinase 1	Homo sapiens	138-142
15770541-8	2005	The cell cycle of HL-60 cells was observed after treatment with zerumbone, which induced G (2)/M cell cycle arrest in HL-60 cells in a time- and concentration-dependent manner, and decreased the cyclin B1/cdk 1 protein level.	zerumbone	64-73	cyclin dependent kinase 1	Homo sapiens	205-210
15582998-6	2005	The p14(ARF)-induced depletion of p34(cdc2) was associated with impaired cdc25C phosphatase expression and a prominent shift to inhibitory Tyr-15-phosphorylation in G(2)-arrested cells lacking either p53, p21, or both.	Tyrosine	139-142	cyclin dependent kinase 1	Homo sapiens	38-42
15536083-9	2005	Western blotting and kinase assays showed that CIL-102 exposure induced up-regulation of cyclin B1 and p34(cdc2) kinase activity and olomoucine, a p34(cdc2) inhibitor, profoundly reduced the number of cells accumulated in mitotic phase.	1-(4-(furo(2,3-b)quinolin-4-ylamino)phenyl)ethanone	47-54	cyclin dependent kinase 1	Homo sapiens	107-111
15670636-4	2005	Resveratrol is able to induce S-phase cell arrest and this interference with the cell cycle is associated with an increase of cyclin E and cyclin A, a downregulation of cyclin D1, and no alteration in cyclin B1 and cdk 1 activation.	Resveratrol	0-11	cyclin dependent kinase 1	Homo sapiens	215-220
15695611-11	2005	When rat oocytes were treated with MG132, a proteasome inhibitor, delayed inactivation of the p34cdc2 kinase was observed in the MG132-treated oocytes.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	35-40	cyclin dependent kinase 1	Homo sapiens	94-101
15695611-11	2005	When rat oocytes were treated with MG132, a proteasome inhibitor, delayed inactivation of the p34cdc2 kinase was observed in the MG132-treated oocytes.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	129-134	cyclin dependent kinase 1	Homo sapiens	94-101
15695611-14	2005	These results suggest that the decreased level of p34cdc2 kinase activity in aged or enucleated rat oocytes is responsible for their inability to support PCC of microinjected donor cell nuclei and that inhibition of p34cdc2 kinase inactivation by chemicals such as MG132 is in part effective for rat oocytes to promote PCC and further development.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	265-270	cyclin dependent kinase 1	Homo sapiens	50-57
15695611-14	2005	These results suggest that the decreased level of p34cdc2 kinase activity in aged or enucleated rat oocytes is responsible for their inability to support PCC of microinjected donor cell nuclei and that inhibition of p34cdc2 kinase inactivation by chemicals such as MG132 is in part effective for rat oocytes to promote PCC and further development.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	265-270	cyclin dependent kinase 1	Homo sapiens	216-223
15531913-5	2005	Forced expression of Cdc2 together with cyclin B attenuated rottlerin-potentiated TRAIL-induced apoptosis by over-riding the rottlerin-mediated downregulation of survivin and XIAP protein levels.	rottlerin	60-69	cyclin dependent kinase 1	Homo sapiens	21-25
15531913-5	2005	Forced expression of Cdc2 together with cyclin B attenuated rottlerin-potentiated TRAIL-induced apoptosis by over-riding the rottlerin-mediated downregulation of survivin and XIAP protein levels.	rottlerin	125-134	cyclin dependent kinase 1	Homo sapiens	21-25
15695611-9	2005	The p34cdc2 kinase level of intact rat oocytes was reduced to the equivalent level of aged (120 min) or enucleated (+60 min) oocytes by a 45 min treatment with roscovitine, an inhibitor of p34cdc2 kinase.	Roscovitine	160-171	cyclin dependent kinase 1	Homo sapiens	4-11
15695611-9	2005	The p34cdc2 kinase level of intact rat oocytes was reduced to the equivalent level of aged (120 min) or enucleated (+60 min) oocytes by a 45 min treatment with roscovitine, an inhibitor of p34cdc2 kinase.	Roscovitine	160-171	cyclin dependent kinase 1	Homo sapiens	189-196
15531913-0	2005	Rottlerin sensitizes glioma cells to TRAIL-induced apoptosis by inhibition of Cdc2 and the subsequent downregulation of survivin and XIAP.	rottlerin	0-9	cyclin dependent kinase 1	Homo sapiens	78-82
15531913-3	2005	Treatment with rottlerin significantly decreased Cdc2 activity through the downregulation of cyclin A, cyclin B, and Cdc2 proteins, whereas the sensitizing effect of rottlerin on TRAIL-induced apoptosis was independent of PKCdelta activity.	rottlerin	15-24	cyclin dependent kinase 1	Homo sapiens	49-53
15531913-3	2005	Treatment with rottlerin significantly decreased Cdc2 activity through the downregulation of cyclin A, cyclin B, and Cdc2 proteins, whereas the sensitizing effect of rottlerin on TRAIL-induced apoptosis was independent of PKCdelta activity.	rottlerin	15-24	cyclin dependent kinase 1	Homo sapiens	117-121
15536083-9	2005	Western blotting and kinase assays showed that CIL-102 exposure induced up-regulation of cyclin B1 and p34(cdc2) kinase activity and olomoucine, a p34(cdc2) inhibitor, profoundly reduced the number of cells accumulated in mitotic phase.	1-(4-(furo(2,3-b)quinolin-4-ylamino)phenyl)ethanone	47-54	cyclin dependent kinase 1	Homo sapiens	151-155
15603758-5	2005	Gadd45a protein has been reported to interact with multiple important cellular proteins, including Cdc2 protein kinase, proliferating cell nuclear antigen (PCNA), p21Waf1/Cip1 protein, core histone protein and MTK/MEKK4, an up-stream activator of the JNK/SAPK pathway, indicating that Gadd45a may play important roles in the control of cell cycle checkpoint, DNA repair process, and signaling transduction.	gadd45a	0-7	cyclin dependent kinase 1	Homo sapiens	99-103
15709490-4	2005	Mutation of the serine 26 residue and inhibition of Abeta phosphorylation by the CDK-1 inhibitor olomoucine prevented Abeta toxicity, suggesting that the phosphorylated Abeta peptide represents a toxic intermediate.	olomoucine	97-107	cyclin dependent kinase 1	Homo sapiens	81-86
17191919-8	2005	One product, indirubin 5,5"-dicarboxylic acid 5-methyl ester, inhibited GSK-3alpha/beta with an IC50 of 14 nM and selectivity nearly 40-fold over CDK1 and CDK5.	indirubin 5,5"-dicarboxylic acid 5-methyl ester	13-60	cyclin dependent kinase 1	Homo sapiens	146-150
17191919-9	2005	Indirubin-5-5"-dicarbonitrile was also modified to the corresponding 3"-oxime, which had low specificity but showed very high inhibition of all three kinases with IC50 values of 5, 13, and 10 nM towards GSK-3alpha/beta, CDK1, and CDK5, respectively.	indirubin-5-5"-dicarbonitrile	0-29	cyclin dependent kinase 1	Homo sapiens	220-224
17191919-9	2005	Indirubin-5-5"-dicarbonitrile was also modified to the corresponding 3"-oxime, which had low specificity but showed very high inhibition of all three kinases with IC50 values of 5, 13, and 10 nM towards GSK-3alpha/beta, CDK1, and CDK5, respectively.	3"-oxime	69-77	cyclin dependent kinase 1	Homo sapiens	220-224
15853645-8	2005	Although they are competitive with ATP at the catalytic site, their kinase selectivity varies greatly, and inhibitors selective for certain CDKs have begun to be identified.	Adenosine Triphosphate	35-38	cyclin dependent kinase 1	Homo sapiens	140-144
15615778-3	2005	The p53-independent pathway involves a phosphorylation cascade that activates the Chk1 effector kinase and induces G2 arrest through inhibitory tyrosine phosphorylation of Cdc2.	Tyrosine	144-152	cyclin dependent kinase 1	Homo sapiens	172-176
15576941-2	2005	They function by phosphorylating Cdc2 and related Cdks on conserved tyrosine and threonine residues.	Tyrosine	68-76	cyclin dependent kinase 1	Homo sapiens	33-37
15576941-2	2005	They function by phosphorylating Cdc2 and related Cdks on conserved tyrosine and threonine residues.	Tyrosine	68-76	cyclin dependent kinase 1	Homo sapiens	50-54
15576941-2	2005	They function by phosphorylating Cdc2 and related Cdks on conserved tyrosine and threonine residues.	Threonine	81-90	cyclin dependent kinase 1	Homo sapiens	33-37
15576941-2	2005	They function by phosphorylating Cdc2 and related Cdks on conserved tyrosine and threonine residues.	Threonine	81-90	cyclin dependent kinase 1	Homo sapiens	50-54
15860443-12	2005	Ferulic acid treatment led to increased levels of cyclin B1 and cdc2 in both cell lines, and p21waf1/cip1 was induced in the malignant cell line.	ferulic acid	0-12	cyclin dependent kinase 1	Homo sapiens	64-68
15860443-13	2005	beta-sitosterol reduced the levels of cyclin B1 and cdc2 while increasing p21waf1/cip1 in both the premalignant and malignant cell lines.	gamma-sitosterol	0-15	cyclin dependent kinase 1	Homo sapiens	52-56
15541388-5	2004	During mitosis, TOPK-Thr-9 was phosphorylated by cdk1/cyclin B and TOPK significantly associates with mitotic spindles.	Threonine	21-24	cyclin dependent kinase 1	Homo sapiens	49-53
15483186-8	2005	The indole-mediated cell-cycle arrest may be related to the increased levels of the CDK-inhibitors p21 and p27 (only induced by NI3C).	indole	4-10	cyclin dependent kinase 1	Homo sapiens	84-87
15483186-8	2005	The indole-mediated cell-cycle arrest may be related to the increased levels of the CDK-inhibitors p21 and p27 (only induced by NI3C).	N-methoxyindole-3-carbinol	128-132	cyclin dependent kinase 1	Homo sapiens	84-87
15601545-13	2004	Asiaticoside plus vincristine enhanced S-G(2)/M arrest, up-regulated Cyclin B1 protein expression, and down-regulated P34(cdc2) protein expression in KB cells.	asiaticoside	0-12	cyclin dependent kinase 1	Homo sapiens	118-126
15456784-5	2004	Additionally, quercetin inhibited the cell growth, increased the fractions of G(2)/M phase, and raised the levels of cyclin B1 and phospho-cdc2 (threonine 161) proteins.	Quercetin	14-23	cyclin dependent kinase 1	Homo sapiens	139-143
15456784-5	2004	Additionally, quercetin inhibited the cell growth, increased the fractions of G(2)/M phase, and raised the levels of cyclin B1 and phospho-cdc2 (threonine 161) proteins.	Threonine	145-154	cyclin dependent kinase 1	Homo sapiens	139-143
15386387-6	2004	In contrast, cells stably expressing H179L-p53 arrested in S-phase following cisplatin treatment, which correlated with a marked decrease in the expression of cdc2, cyclin B1 and cyclin A, and a decrease in CDK2 and cyclin A-associated kinase activity.	Cisplatin	77-86	cyclin dependent kinase 1	Homo sapiens	159-163
15529313-13	2004	CONCLUSIONS: SarCNU induced G2/M arrest in prostate carcinoma cells via p53-dependent up-regulation of p21Cip1/Waf1 and p53-independent phosphorylation of Cdc-2 at Tyr15.	2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)propanamide	13-19	cyclin dependent kinase 1	Homo sapiens	155-160
15604258-3	2004	A complete inactivation of cdc2 by either introduction of DNA double-strand breaks or roscovitine treatment prevents exit from mitosis.	Roscovitine	86-97	cyclin dependent kinase 1	Homo sapiens	27-31
15601545-13	2004	Asiaticoside plus vincristine enhanced S-G(2)/M arrest, up-regulated Cyclin B1 protein expression, and down-regulated P34(cdc2) protein expression in KB cells.	Vincristine	18-29	cyclin dependent kinase 1	Homo sapiens	118-126
15313404-6	2004	Eupatilin inhibited the expression of cyclin D1, cyclin B1, Cdk2 and Cdc2 that are key regulators of the cell cycle.	eupatilin	0-9	cyclin dependent kinase 1	Homo sapiens	69-73
15317660-7	2004	Finally, the CDK1/cdc2 inhibitor roscovitine reduces the proliferation of several tumor cell lines, suggesting that inhibition of CDK1/cdc2 may be a useful strategy against malignant transformation.	Roscovitine	33-44	cyclin dependent kinase 1	Homo sapiens	13-17
15317660-7	2004	Finally, the CDK1/cdc2 inhibitor roscovitine reduces the proliferation of several tumor cell lines, suggesting that inhibition of CDK1/cdc2 may be a useful strategy against malignant transformation.	Roscovitine	33-44	cyclin dependent kinase 1	Homo sapiens	18-22
15317660-7	2004	Finally, the CDK1/cdc2 inhibitor roscovitine reduces the proliferation of several tumor cell lines, suggesting that inhibition of CDK1/cdc2 may be a useful strategy against malignant transformation.	Roscovitine	33-44	cyclin dependent kinase 1	Homo sapiens	130-134
15317660-7	2004	Finally, the CDK1/cdc2 inhibitor roscovitine reduces the proliferation of several tumor cell lines, suggesting that inhibition of CDK1/cdc2 may be a useful strategy against malignant transformation.	Roscovitine	33-44	cyclin dependent kinase 1	Homo sapiens	135-139
15500931-5	2004	According to the Western blot analysis, DATS decreased cyclin-dependent kinase (Cdks)-Cdk7 (i.e. Cdc2 activate kinase) protein levels in J5 cells but increased cyclin B1 protein level.	diallyl trisulfide	40-44	cyclin dependent kinase 1	Homo sapiens	80-84
15500931-5	2004	According to the Western blot analysis, DATS decreased cyclin-dependent kinase (Cdks)-Cdk7 (i.e. Cdc2 activate kinase) protein levels in J5 cells but increased cyclin B1 protein level.	diallyl trisulfide	40-44	cyclin dependent kinase 1	Homo sapiens	97-101
15389828-7	2004	Possible involvement of cyclin-dependent kinases (CDKs) in c-Jun phosphorylation at Ser63 was excluded by pretreating UV-irradiated SH-SY5Y cells with the CDK1/2/5 inhibitor roscovitine.	Roscovitine	174-185	cyclin dependent kinase 1	Homo sapiens	50-54
15389828-7	2004	Possible involvement of cyclin-dependent kinases (CDKs) in c-Jun phosphorylation at Ser63 was excluded by pretreating UV-irradiated SH-SY5Y cells with the CDK1/2/5 inhibitor roscovitine.	Roscovitine	174-185	cyclin dependent kinase 1	Homo sapiens	155-163
15474478-1	2004	Roscovitine and flavopiridol have been shown to potently inhibit cyclin-dependent kinase 1 and 2 (CDK1 and 2).	Roscovitine	0-11	cyclin dependent kinase 1	Homo sapiens	65-96
15474478-1	2004	Roscovitine and flavopiridol have been shown to potently inhibit cyclin-dependent kinase 1 and 2 (CDK1 and 2).	Roscovitine	0-11	cyclin dependent kinase 1	Homo sapiens	98-108
15474478-1	2004	Roscovitine and flavopiridol have been shown to potently inhibit cyclin-dependent kinase 1 and 2 (CDK1 and 2).	alvocidib	16-28	cyclin dependent kinase 1	Homo sapiens	65-96
15474478-1	2004	Roscovitine and flavopiridol have been shown to potently inhibit cyclin-dependent kinase 1 and 2 (CDK1 and 2).	alvocidib	16-28	cyclin dependent kinase 1	Homo sapiens	98-108
15474478-3	2004	The present work describes two molecular models for the binary complexes CDK1:roscovitine and CDK1:flavopiridol.	Roscovitine	78-89	cyclin dependent kinase 1	Homo sapiens	73-77
15474478-3	2004	The present work describes two molecular models for the binary complexes CDK1:roscovitine and CDK1:flavopiridol.	alvocidib	99-111	cyclin dependent kinase 1	Homo sapiens	73-77
15474478-3	2004	The present work describes two molecular models for the binary complexes CDK1:roscovitine and CDK1:flavopiridol.	alvocidib	99-111	cyclin dependent kinase 1	Homo sapiens	94-98
15474478-4	2004	These structural models indicate that both inhibitors strongly bind to the ATP-binding pocket of CDK1 and structural comparison of the CDK complexes correlates the structures with differences in inhibition of these CDKs by flavopiridol and roscovitine.	Adenosine Triphosphate	75-78	cyclin dependent kinase 1	Homo sapiens	97-101
15474478-4	2004	These structural models indicate that both inhibitors strongly bind to the ATP-binding pocket of CDK1 and structural comparison of the CDK complexes correlates the structures with differences in inhibition of these CDKs by flavopiridol and roscovitine.	Adenosine Triphosphate	75-78	cyclin dependent kinase 1	Homo sapiens	215-219
15474478-4	2004	These structural models indicate that both inhibitors strongly bind to the ATP-binding pocket of CDK1 and structural comparison of the CDK complexes correlates the structures with differences in inhibition of these CDKs by flavopiridol and roscovitine.	alvocidib	223-235	cyclin dependent kinase 1	Homo sapiens	97-101
15474478-4	2004	These structural models indicate that both inhibitors strongly bind to the ATP-binding pocket of CDK1 and structural comparison of the CDK complexes correlates the structures with differences in inhibition of these CDKs by flavopiridol and roscovitine.	alvocidib	223-235	cyclin dependent kinase 1	Homo sapiens	215-219
15474478-4	2004	These structural models indicate that both inhibitors strongly bind to the ATP-binding pocket of CDK1 and structural comparison of the CDK complexes correlates the structures with differences in inhibition of these CDKs by flavopiridol and roscovitine.	Roscovitine	240-251	cyclin dependent kinase 1	Homo sapiens	97-101
15474478-4	2004	These structural models indicate that both inhibitors strongly bind to the ATP-binding pocket of CDK1 and structural comparison of the CDK complexes correlates the structures with differences in inhibition of these CDKs by flavopiridol and roscovitine.	Roscovitine	240-251	cyclin dependent kinase 1	Homo sapiens	215-219
15466404-6	2004	Inhibition of p34(cdc2) activity by purvalanol A caused mitotic-arrested cells to rapidly exit mitosis, suggesting that sustained p34(cdc2) activity was responsible for metaphase arrest.	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	36-48	cyclin dependent kinase 1	Homo sapiens	18-22
15466404-6	2004	Inhibition of p34(cdc2) activity by purvalanol A caused mitotic-arrested cells to rapidly exit mitosis, suggesting that sustained p34(cdc2) activity was responsible for metaphase arrest.	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	36-48	cyclin dependent kinase 1	Homo sapiens	134-138
15302583-8	2004	In summary, TPA-induced TIS21 mRNA expression is mediated by PKC-delta, and TIS21 induces G2/M arrest and cell death by inhibiting cyclin B1-Cdc2 binding and the kinase activity through its binding to Cdc2.	Tetradecanoylphorbol Acetate	12-15	cyclin dependent kinase 1	Homo sapiens	141-145
15302583-8	2004	In summary, TPA-induced TIS21 mRNA expression is mediated by PKC-delta, and TIS21 induces G2/M arrest and cell death by inhibiting cyclin B1-Cdc2 binding and the kinase activity through its binding to Cdc2.	Tetradecanoylphorbol Acetate	12-15	cyclin dependent kinase 1	Homo sapiens	201-205
15117815-6	2004	In other studies, silibinin treatment strongly induced the expression of Cip1/p21 and Kip1/p27, but resulted in a decrease in cyclin-dependent kinases (CDKs) and cyclins involved in G(1) progression.	Silybin	18-27	cyclin dependent kinase 1	Homo sapiens	152-156
15362121-0	2004	CDK1-inhibitory activity of paullones depends on electronic properties of 9-substituents.	paullone	28-37	cyclin dependent kinase 1	Homo sapiens	0-4
15362121-3	2004	The equation solely based on the electronic parameter was successfully used for the prediction of the CDK1-inhibitory activity of a small test set comprising novel paullones with sulfur-containing 9-substituents.	paullone	164-173	cyclin dependent kinase 1	Homo sapiens	102-106
15362121-3	2004	The equation solely based on the electronic parameter was successfully used for the prediction of the CDK1-inhibitory activity of a small test set comprising novel paullones with sulfur-containing 9-substituents.	Sulfur	179-185	cyclin dependent kinase 1	Homo sapiens	102-106
15362121-4	2004	Among these new derivatives, 2-methoxy-9-methylsulfonylpaullone proved to be superior to the standard alsterpaullone with respect to CDK1 inhibition.	2-methoxy-9-methylsulfonylpaullone	29-63	cyclin dependent kinase 1	Homo sapiens	133-137
15362121-4	2004	Among these new derivatives, 2-methoxy-9-methylsulfonylpaullone proved to be superior to the standard alsterpaullone with respect to CDK1 inhibition.	alsterpaullone	102-116	cyclin dependent kinase 1	Homo sapiens	133-137
15117815-7	2004	Silibinin treatment also showed an increased interaction between cyclin-dependent kinase inhibitors (CDKIs)-CDKs and a decreased CDK kinase activity.	Silybin	0-9	cyclin dependent kinase 1	Homo sapiens	108-112
15117815-8	2004	Further, the G(2)/M arrest by silibinin in TCC-SUP cells was associated with a decrease in pCdc25c (Ser216), Cdc25c, pCdc2 (Tyr15), Cdc2 and cyclin B1 protein levels.	Silybin	30-39	cyclin dependent kinase 1	Homo sapiens	92-96
15308730-1	2004	Flavopiridol, roscovitine, and other inhibitors of Cyclin-Dependent Kinases (CDK) inhibit the replication of a variety of viruses in vitro while proving nontoxic in human clinical trials of their effects against cancer.	alvocidib	0-12	cyclin dependent kinase 1	Homo sapiens	77-80
15342418-7	2004	P21Cip1, cdk1, cdk2, and cyclin E mRNA expression increased coincident with S-phase accumulation in HT29 cells treated with ZD9331 or 5fluorouracil/leucovorin, as demonstrated by cDNA microarray analyses.	ZD 9331	124-130	cyclin dependent kinase 1	Homo sapiens	9-13
15342418-7	2004	P21Cip1, cdk1, cdk2, and cyclin E mRNA expression increased coincident with S-phase accumulation in HT29 cells treated with ZD9331 or 5fluorouracil/leucovorin, as demonstrated by cDNA microarray analyses.	Fluorouracil	134-147	cyclin dependent kinase 1	Homo sapiens	9-13
15308730-1	2004	Flavopiridol, roscovitine, and other inhibitors of Cyclin-Dependent Kinases (CDK) inhibit the replication of a variety of viruses in vitro while proving nontoxic in human clinical trials of their effects against cancer.	Roscovitine	14-25	cyclin dependent kinase 1	Homo sapiens	77-80
15308730-3	2004	Flavopiridol potently inhibits all tested CDKs and inhibits the transcription of most cellular and viral genes.	alvocidib	0-12	cyclin dependent kinase 1	Homo sapiens	42-46
15308730-4	2004	In contrast, roscovitine and other purine PCIs inhibit with high potency only CDK1, CDK2, CDK5, and CDK7, and they specifically inhibit the expression of viral but not cellular genes.	Roscovitine	13-24	cyclin dependent kinase 1	Homo sapiens	78-82
15308730-4	2004	In contrast, roscovitine and other purine PCIs inhibit with high potency only CDK1, CDK2, CDK5, and CDK7, and they specifically inhibit the expression of viral but not cellular genes.	purine	35-41	cyclin dependent kinase 1	Homo sapiens	78-82
15248095-6	2004	Using a bioinformatics approach, we found that the highly conserved S44 is predicted to be phosphorylated by a number of family members of the proline-directed serine/threonine cyclin-dependent kinases (Cdks).	Proline	143-150	cyclin dependent kinase 1	Homo sapiens	203-207
15248095-6	2004	Using a bioinformatics approach, we found that the highly conserved S44 is predicted to be phosphorylated by a number of family members of the proline-directed serine/threonine cyclin-dependent kinases (Cdks).	Serine	160-166	cyclin dependent kinase 1	Homo sapiens	203-207
15276324-3	2004	The Cdc2 phosphorylation level of oxaline-treated cell lysate was lower than that of the control cells, indicating that oxaline arrests the M phase.	oxaline	34-41	cyclin dependent kinase 1	Homo sapiens	4-8
15298730-5	2004	Etodolac induced p21WAF1/Cip1 and p27Kip1 expression and inhibited CDK2, CDK4, CDC2, cyclin A and cyclin B1 expression, but did not affect cyclin D1 or cyclin E. HGF and 10% FBS induced ERK phosphorylation, but phosphorylation of p38, JNK and AKT was down-regulated by etodolac.	Etodolac	0-8	cyclin dependent kinase 1	Homo sapiens	79-83
15473647-6	2004	In vitro kinase activity assay demonstrated that the enzymatic activity of the cyclin B1/cyclin-dependent kinase 1 complex was reduced in liriodenine-treated cells.	liriodenine	138-149	cyclin dependent kinase 1	Homo sapiens	89-114
15208305-5	2004	Activation of the Ras-Ral signaling affected neither the level nor the intracellular localization of cyclin B1 and CDC2 but interfered with the CDC2 inhibitory phosphorylation at Tyr(15) and the decrease in the cyclin B/CDC2 kinase activity in damaged cells.	Tyrosine	179-182	cyclin dependent kinase 1	Homo sapiens	144-148
15208305-5	2004	Activation of the Ras-Ral signaling affected neither the level nor the intracellular localization of cyclin B1 and CDC2 but interfered with the CDC2 inhibitory phosphorylation at Tyr(15) and the decrease in the cyclin B/CDC2 kinase activity in damaged cells.	Tyrosine	179-182	cyclin dependent kinase 1	Homo sapiens	144-148
15145941-0	2004	Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region.	Proline	128-135	cyclin dependent kinase 1	Homo sapiens	45-49
15145941-6	2004	In the SCF(Fbx7) complex, Fbx7 recruits HURP through its C-terminal proline-rich region in a Cdk1-cyclin B-phosphorylation dependent manner.	Proline	68-75	cyclin dependent kinase 1	Homo sapiens	93-97
15276324-3	2004	The Cdc2 phosphorylation level of oxaline-treated cell lysate was lower than that of the control cells, indicating that oxaline arrests the M phase.	oxaline	120-127	cyclin dependent kinase 1	Homo sapiens	4-8
15169628-6	2004	Measurements of cyclin A and B protein levels, Cdk2 and Cdc2 kinase activities, Cdc25C phosphorylation, and Chk1 kinase activity were consistent with UCN-01-induced abrogation of the S/G2-phase checkpoint in ara-C treated cells.	7-hydroxystaurosporine	150-156	cyclin dependent kinase 1	Homo sapiens	56-60
15269161-9	2004	In addition, biochemical examinations revealed that gamma-radiation inhibited paclitaxel-induced IkappaBalpha degradation and bcl-2 phosphorylation and increased the protein levels of cyclin B1 and inhibitory phosphorylation of p34(cdc2).	Paclitaxel	78-88	cyclin dependent kinase 1	Homo sapiens	232-236
15146552-11	2004	The G2/M arrest was accompanied by an elevated p34(cdc2) kinase activity and an increase in the protein expression of cyclin B1 and phosphorylated form of p34(cdc2) (Thr 161).	Threonine	166-169	cyclin dependent kinase 1	Homo sapiens	159-163
15203004-7	2004	One site, serine 11, is targeted by CDK1/cyclin B and is phosphorylated in mitotic human cells.	Serine	10-16	cyclin dependent kinase 1	Homo sapiens	36-40
15239650-0	2004	N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2.	n2-substituted o6-cyclohexylmethylguanine	0-41	cyclin dependent kinase 1	Homo sapiens	76-108
15239650-1	2004	The adenosine 5"-triphosphate (ATP) competitive cyclin-dependent kinase inhibitor O(6)-cyclohexylmethylguanine (NU2058, 1) has been employed as the lead in a structure-based drug discovery program resulting in the discovery of the potent CDK1 and -2 inhibitor NU6102 (3, IC(50) = 9.5 nM and 5.4 nM vs CDK1/cyclinB and CDK2/cyclinA3, respectively).	Adenosine Triphosphate	4-29	cyclin dependent kinase 1	Homo sapiens	238-249
15239650-1	2004	The adenosine 5"-triphosphate (ATP) competitive cyclin-dependent kinase inhibitor O(6)-cyclohexylmethylguanine (NU2058, 1) has been employed as the lead in a structure-based drug discovery program resulting in the discovery of the potent CDK1 and -2 inhibitor NU6102 (3, IC(50) = 9.5 nM and 5.4 nM vs CDK1/cyclinB and CDK2/cyclinA3, respectively).	Adenosine Triphosphate	4-29	cyclin dependent kinase 1	Homo sapiens	238-242
15239650-1	2004	The adenosine 5"-triphosphate (ATP) competitive cyclin-dependent kinase inhibitor O(6)-cyclohexylmethylguanine (NU2058, 1) has been employed as the lead in a structure-based drug discovery program resulting in the discovery of the potent CDK1 and -2 inhibitor NU6102 (3, IC(50) = 9.5 nM and 5.4 nM vs CDK1/cyclinB and CDK2/cyclinA3, respectively).	Adenosine Triphosphate	31-34	cyclin dependent kinase 1	Homo sapiens	238-249
15239650-1	2004	The adenosine 5"-triphosphate (ATP) competitive cyclin-dependent kinase inhibitor O(6)-cyclohexylmethylguanine (NU2058, 1) has been employed as the lead in a structure-based drug discovery program resulting in the discovery of the potent CDK1 and -2 inhibitor NU6102 (3, IC(50) = 9.5 nM and 5.4 nM vs CDK1/cyclinB and CDK2/cyclinA3, respectively).	Adenosine Triphosphate	31-34	cyclin dependent kinase 1	Homo sapiens	238-242
15239650-1	2004	The adenosine 5"-triphosphate (ATP) competitive cyclin-dependent kinase inhibitor O(6)-cyclohexylmethylguanine (NU2058, 1) has been employed as the lead in a structure-based drug discovery program resulting in the discovery of the potent CDK1 and -2 inhibitor NU6102 (3, IC(50) = 9.5 nM and 5.4 nM vs CDK1/cyclinB and CDK2/cyclinA3, respectively).	NU2058	82-110	cyclin dependent kinase 1	Homo sapiens	238-249
15239650-1	2004	The adenosine 5"-triphosphate (ATP) competitive cyclin-dependent kinase inhibitor O(6)-cyclohexylmethylguanine (NU2058, 1) has been employed as the lead in a structure-based drug discovery program resulting in the discovery of the potent CDK1 and -2 inhibitor NU6102 (3, IC(50) = 9.5 nM and 5.4 nM vs CDK1/cyclinB and CDK2/cyclinA3, respectively).	NU2058	82-110	cyclin dependent kinase 1	Homo sapiens	238-242
15239650-1	2004	The adenosine 5"-triphosphate (ATP) competitive cyclin-dependent kinase inhibitor O(6)-cyclohexylmethylguanine (NU2058, 1) has been employed as the lead in a structure-based drug discovery program resulting in the discovery of the potent CDK1 and -2 inhibitor NU6102 (3, IC(50) = 9.5 nM and 5.4 nM vs CDK1/cyclinB and CDK2/cyclinA3, respectively).	NU2058	112-118	cyclin dependent kinase 1	Homo sapiens	238-249
15239650-1	2004	The adenosine 5"-triphosphate (ATP) competitive cyclin-dependent kinase inhibitor O(6)-cyclohexylmethylguanine (NU2058, 1) has been employed as the lead in a structure-based drug discovery program resulting in the discovery of the potent CDK1 and -2 inhibitor NU6102 (3, IC(50) = 9.5 nM and 5.4 nM vs CDK1/cyclinB and CDK2/cyclinA3, respectively).	NU2058	112-118	cyclin dependent kinase 1	Homo sapiens	238-242
15257900-3	2004	Western blotting was adopted for detecting the expression of cdc2 and phos-cdc2 induced by XK469 and adriamycin.	Doxorubicin	101-111	cyclin dependent kinase 1	Homo sapiens	61-65
15257900-3	2004	Western blotting was adopted for detecting the expression of cdc2 and phos-cdc2 induced by XK469 and adriamycin.	Doxorubicin	101-111	cyclin dependent kinase 1	Homo sapiens	75-79
15257900-4	2004	RESULTS: Different concentrations of XK469 and adriamycin could significantly inhibit the growth of H460 cells, induce their G2/M phase arrest, and increase phos-cdc2 expression; XN472 had a lesser effect on the growth of H460 cells.	Doxorubicin	47-57	cyclin dependent kinase 1	Homo sapiens	162-166
15217973-1	2004	Flavopiridol is the first potent inhibitor of cyclin-dependent kinases (cdks) to reach clinical trial.	alvocidib	0-12	cyclin dependent kinase 1	Homo sapiens	72-76
15217973-9	2004	Inhibition of cyclin B-cdk1 by flavopiridol accelerates exit from an abnormal mitosis associated with taxane-induced cell death and reduces the phosphorylation of survivin, preventing its stabilization and the cellular protection it affords after taxane exposure.	alvocidib	31-43	cyclin dependent kinase 1	Homo sapiens	23-27
15217973-9	2004	Inhibition of cyclin B-cdk1 by flavopiridol accelerates exit from an abnormal mitosis associated with taxane-induced cell death and reduces the phosphorylation of survivin, preventing its stabilization and the cellular protection it affords after taxane exposure.	taxane	102-108	cyclin dependent kinase 1	Homo sapiens	23-27
15217973-9	2004	Inhibition of cyclin B-cdk1 by flavopiridol accelerates exit from an abnormal mitosis associated with taxane-induced cell death and reduces the phosphorylation of survivin, preventing its stabilization and the cellular protection it affords after taxane exposure.	taxane	247-253	cyclin dependent kinase 1	Homo sapiens	23-27
15073169-3	2004	Cell cycle arrest induced by SFN was associated with a significant decrease in protein levels of cyclin B1, cell division cycle (Cdc) 25B, and Cdc25C, leading to accumulation of Tyr-15-phosphorylated (inactive) cyclin-dependent kinase 1.	sulforaphane	29-32	cyclin dependent kinase 1	Homo sapiens	211-236
15204521-9	2004	Time-course changes of cell cycle regulatory proteins levels revealed accumulation of cyclins A and B as well as of cdc2 and cdk2 upon exposure of IGROV-1 cells to hyperthermia and oxaliplatin.	Oxaliplatin	181-192	cyclin dependent kinase 1	Homo sapiens	116-120
15048074-5	2004	Inhibition of Chk2 by transfection of a dominant-negative Chk2 mutant or a chemical inhibitor, debromohymenialdesine, stabilizes centrosomes, maintains high cyclin B1 levels, and allows for a prolonged activation of Cdk1.	debromohymenialdisine	95-116	cyclin dependent kinase 1	Homo sapiens	216-220
15175024-0	2004	Keratinocyte G2/M growth arrest by 1,25-dihydroxyvitamin D3 is caused by Cdc2 phosphorylation through Wee1 and Myt1 regulation.	Calcitriol	35-59	cyclin dependent kinase 1	Homo sapiens	73-77
15136770-6	2004	Treatment of cells with the S-phase blocker PD179483 causes abnormal and persistent hyperactivation of Cdk2 and Cdc2 due to Tyr-15 dephosphorylation.	PD179483	44-52	cyclin dependent kinase 1	Homo sapiens	112-116
15136770-6	2004	Treatment of cells with the S-phase blocker PD179483 causes abnormal and persistent hyperactivation of Cdk2 and Cdc2 due to Tyr-15 dephosphorylation.	Tyrosine	124-127	cyclin dependent kinase 1	Homo sapiens	112-116
15200121-4	2004	The p38 inhibitor SB203580 or the Chk1 inhibitor UCN-01 or their combination blocked TMZ-mediated inactivation of cdc25C and cdc2, suggesting that p38 and Chk1 pathways work cooperatively and are both necessary to inactivate cdc25C and cdc2.	SB 203580	18-26	cyclin dependent kinase 1	Homo sapiens	114-118
15200121-4	2004	The p38 inhibitor SB203580 or the Chk1 inhibitor UCN-01 or their combination blocked TMZ-mediated inactivation of cdc25C and cdc2, suggesting that p38 and Chk1 pathways work cooperatively and are both necessary to inactivate cdc25C and cdc2.	SB 203580	18-26	cyclin dependent kinase 1	Homo sapiens	125-129
15200121-4	2004	The p38 inhibitor SB203580 or the Chk1 inhibitor UCN-01 or their combination blocked TMZ-mediated inactivation of cdc25C and cdc2, suggesting that p38 and Chk1 pathways work cooperatively and are both necessary to inactivate cdc25C and cdc2.	7-hydroxystaurosporine	49-52	cyclin dependent kinase 1	Homo sapiens	114-118
15200121-4	2004	The p38 inhibitor SB203580 or the Chk1 inhibitor UCN-01 or their combination blocked TMZ-mediated inactivation of cdc25C and cdc2, suggesting that p38 and Chk1 pathways work cooperatively and are both necessary to inactivate cdc25C and cdc2.	7-hydroxystaurosporine	49-52	cyclin dependent kinase 1	Homo sapiens	125-129
15200121-4	2004	The p38 inhibitor SB203580 or the Chk1 inhibitor UCN-01 or their combination blocked TMZ-mediated inactivation of cdc25C and cdc2, suggesting that p38 and Chk1 pathways work cooperatively and are both necessary to inactivate cdc25C and cdc2.	Temozolomide	85-88	cyclin dependent kinase 1	Homo sapiens	114-118
15200121-4	2004	The p38 inhibitor SB203580 or the Chk1 inhibitor UCN-01 or their combination blocked TMZ-mediated inactivation of cdc25C and cdc2, suggesting that p38 and Chk1 pathways work cooperatively and are both necessary to inactivate cdc25C and cdc2.	Temozolomide	85-88	cyclin dependent kinase 1	Homo sapiens	125-129
15141014-7	2004	The PEITC-induced decline in Cdk1 and Cdc25C protein levels and cell cycle arrest were significantly blocked on pretreatment of PC-3 cells with proteasome inhibitor lactacystin.	lactacystin	165-176	cyclin dependent kinase 1	Homo sapiens	29-33
15016823-9	2004	This mitosis-specific phosphorylation was inhibited by treatment of the cells with roscovitine, a specific inhibitor of cyclin-dependent kinases, suggesting that the unknown activity of the moca domain of SRcyp requires mitotic regulation by the Cdc2-cyclin B kinase complex.	Roscovitine	83-94	cyclin dependent kinase 1	Homo sapiens	246-250
15130771-2	2004	Consequently, pharmacologic inhibitors, such as 2,6,9-trisubstituted purines, which potently inhibit CDKs 1, 2, and 5, were developed to combat these pathologies.	2,6,9-trisubstituted purines	48-76	cyclin dependent kinase 1	Homo sapiens	101-105
15130771-5	2004	Herein we demonstrate that three 2,6,9-trisubstituted purines: olomoucine, roscovitine, and purvalanol, used at concentrations ascribed by others to potently inhibit CDKs 1, 2, and 5, are powerful triggers of death in maturing cerebellar granule neurons, assessed by loss of mitochondrial reductive capacity and differential staining with fluorescent indicators of living/dead neurons.	2,6,9-trisubstituted	33-53	cyclin dependent kinase 1	Homo sapiens	166-170
15130771-5	2004	Herein we demonstrate that three 2,6,9-trisubstituted purines: olomoucine, roscovitine, and purvalanol, used at concentrations ascribed by others to potently inhibit CDKs 1, 2, and 5, are powerful triggers of death in maturing cerebellar granule neurons, assessed by loss of mitochondrial reductive capacity and differential staining with fluorescent indicators of living/dead neurons.	Purines	54-61	cyclin dependent kinase 1	Homo sapiens	166-170
15130771-5	2004	Herein we demonstrate that three 2,6,9-trisubstituted purines: olomoucine, roscovitine, and purvalanol, used at concentrations ascribed by others to potently inhibit CDKs 1, 2, and 5, are powerful triggers of death in maturing cerebellar granule neurons, assessed by loss of mitochondrial reductive capacity and differential staining with fluorescent indicators of living/dead neurons.	olomoucine	63-73	cyclin dependent kinase 1	Homo sapiens	166-170
15130771-5	2004	Herein we demonstrate that three 2,6,9-trisubstituted purines: olomoucine, roscovitine, and purvalanol, used at concentrations ascribed by others to potently inhibit CDKs 1, 2, and 5, are powerful triggers of death in maturing cerebellar granule neurons, assessed by loss of mitochondrial reductive capacity and differential staining with fluorescent indicators of living/dead neurons.	Roscovitine	75-86	cyclin dependent kinase 1	Homo sapiens	166-170
15130771-5	2004	Herein we demonstrate that three 2,6,9-trisubstituted purines: olomoucine, roscovitine, and purvalanol, used at concentrations ascribed by others to potently inhibit CDKs 1, 2, and 5, are powerful triggers of death in maturing cerebellar granule neurons, assessed by loss of mitochondrial reductive capacity and differential staining with fluorescent indicators of living/dead neurons.	purvalanol B	92-102	cyclin dependent kinase 1	Homo sapiens	166-170
15274312-0	2004	Characterization of the CDP-like/CTAS-1 binding site in the okadaic acid response element (OARE) of the human CDK1(p34cdc2) promoter.	Okadaic Acid	60-72	cyclin dependent kinase 1	Homo sapiens	110-114
15274312-0	2004	Characterization of the CDP-like/CTAS-1 binding site in the okadaic acid response element (OARE) of the human CDK1(p34cdc2) promoter.	Okadaic Acid	60-72	cyclin dependent kinase 1	Homo sapiens	115-122
15274312-1	2004	BACKGROUND: Transcription of CDK1 is induced at the G0/G1-phase of the cell cycle and after okadaic acid treatment and we identified the Site I okadaic acid response element (OARE -944 to -763nt) enhancer in the human CDK1 promoter.	Okadaic Acid	92-104	cyclin dependent kinase 1	Homo sapiens	29-33
15274312-1	2004	BACKGROUND: Transcription of CDK1 is induced at the G0/G1-phase of the cell cycle and after okadaic acid treatment and we identified the Site I okadaic acid response element (OARE -944 to -763nt) enhancer in the human CDK1 promoter.	Okadaic Acid	92-104	cyclin dependent kinase 1	Homo sapiens	218-222
15274312-1	2004	BACKGROUND: Transcription of CDK1 is induced at the G0/G1-phase of the cell cycle and after okadaic acid treatment and we identified the Site I okadaic acid response element (OARE -944 to -763nt) enhancer in the human CDK1 promoter.	Okadaic Acid	144-156	cyclin dependent kinase 1	Homo sapiens	29-33
15274312-1	2004	BACKGROUND: Transcription of CDK1 is induced at the G0/G1-phase of the cell cycle and after okadaic acid treatment and we identified the Site I okadaic acid response element (OARE -944 to -763nt) enhancer in the human CDK1 promoter.	Okadaic Acid	144-156	cyclin dependent kinase 1	Homo sapiens	218-222
15107615-2	2004	The Cdc25 protein phosphatase family activates Cdk1-cyclin B at the G2/M transition by removing inhibitory phosphate groups.	Phosphates	107-116	cyclin dependent kinase 1	Homo sapiens	47-51
15067354-5	2004	Tamoxifen decreased the Ki-67 index by 52.4%, reduced the vascular endothelial growth factor (VEGF) 121 and VEGF165 mRNA by 18.6 and 21.8%, respectively, and suppressed the blood vessel formation, while quercetin modulated the expression and phosphorylation of cdc-2 and cyclin B1, and inhibited the Ki-67 index by 66.0%.	Tamoxifen	0-9	cyclin dependent kinase 1	Homo sapiens	261-266
15141014-0	2004	Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanate-induced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells.	phenethyl isothiocyanate	92-116	cyclin dependent kinase 1	Homo sapiens	63-88
15141014-5	2004	The PEITC-induced cell cycle arrest was associated with a &gt;80% reduction in the protein levels of cyclin-dependent kinase 1 (Cdk1) and cell division cycle 25C (Cdc25C; 24 h after treatment with 10 micro M PEITC), which led to an accumulation of Tyr(15) phosphorylated (inactive) Cdk1.	phenethyl isothiocyanate	4-9	cyclin dependent kinase 1	Homo sapiens	101-126
15141014-5	2004	The PEITC-induced cell cycle arrest was associated with a &gt;80% reduction in the protein levels of cyclin-dependent kinase 1 (Cdk1) and cell division cycle 25C (Cdc25C; 24 h after treatment with 10 micro M PEITC), which led to an accumulation of Tyr(15) phosphorylated (inactive) Cdk1.	phenethyl isothiocyanate	4-9	cyclin dependent kinase 1	Homo sapiens	128-132
15141014-5	2004	The PEITC-induced cell cycle arrest was associated with a &gt;80% reduction in the protein levels of cyclin-dependent kinase 1 (Cdk1) and cell division cycle 25C (Cdc25C; 24 h after treatment with 10 micro M PEITC), which led to an accumulation of Tyr(15) phosphorylated (inactive) Cdk1.	phenethyl isothiocyanate	4-9	cyclin dependent kinase 1	Homo sapiens	282-286
15141014-5	2004	The PEITC-induced cell cycle arrest was associated with a &gt;80% reduction in the protein levels of cyclin-dependent kinase 1 (Cdk1) and cell division cycle 25C (Cdc25C; 24 h after treatment with 10 micro M PEITC), which led to an accumulation of Tyr(15) phosphorylated (inactive) Cdk1.	phenethyl isothiocyanate	208-213	cyclin dependent kinase 1	Homo sapiens	101-126
15141014-12	2004	In conclusion, our data indicate that PEITC-induced cell cycle arrest in PC-3 cells is likely due to proteasome-mediated degradation of Cdc25C and Cdk1, and ectopic expression of Bcl-2 fails to confer resistance to PEITC-induced apoptosis.	phenethyl isothiocyanate	38-43	cyclin dependent kinase 1	Homo sapiens	147-151
15141020-8	2004	Adriamycin inhibits histone H3(Ser10) phosphorylation through inhibitory phosphorylation of CDC2 at low doses and down-regulation of cyclin B1 at high doses.	Doxorubicin	0-10	cyclin dependent kinase 1	Homo sapiens	92-96
15182534-6	2004	Incubation of HL-60 cells with DADS (20 micro mol/L) for 12 h could activate G(2)/M checkpoint and increase the expression of phospho-p38 MAPK, followed by the expression of phospho-Cdc25B and phospho-Cdc2 (P &lt; 0.05).	diallyl disulfide	31-35	cyclin dependent kinase 1	Homo sapiens	182-186
15126376-5	2004	It impairs the proliferation of tumoral cell lines and increases cyclin-dependent kinase 1 inhibitory tyrosine phosphorylation.	Tyrosine	102-110	cyclin dependent kinase 1	Homo sapiens	65-90
15182534-7	2004	SB202190, a specific inhibitor of p38 MAPK, markedly blocked the phosphorylation of p38 MAPK, Cdc25B and Cdc2 (P &lt; 0.05).	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	0-8	cyclin dependent kinase 1	Homo sapiens	94-98
15047157-2	2004	In the present study, harmine was identified from a collection of herbal compounds to be a specific inhibitor of Cdk1/cyclin B, Cdk2/cyclin A, and Cdk5/p25 with IC50 values at low micromoles.	Harmine	22-29	cyclin dependent kinase 1	Homo sapiens	113-117
15047157-4	2004	The CDK inhibition by harmine is competitive with ATP-Mg2+, suggesting that it binds to the ATP-Mg2+-binding pocket of CDKs.	Harmine	22-29	cyclin dependent kinase 1	Homo sapiens	119-123
15047157-4	2004	The CDK inhibition by harmine is competitive with ATP-Mg2+, suggesting that it binds to the ATP-Mg2+-binding pocket of CDKs.	Adenosine Triphosphate	50-53	cyclin dependent kinase 1	Homo sapiens	119-123
15047157-4	2004	The CDK inhibition by harmine is competitive with ATP-Mg2+, suggesting that it binds to the ATP-Mg2+-binding pocket of CDKs.	magnesium ion	54-58	cyclin dependent kinase 1	Homo sapiens	119-123
15047157-4	2004	The CDK inhibition by harmine is competitive with ATP-Mg2+, suggesting that it binds to the ATP-Mg2+-binding pocket of CDKs.	Adenosine Triphosphate	92-95	cyclin dependent kinase 1	Homo sapiens	119-123
15047157-4	2004	The CDK inhibition by harmine is competitive with ATP-Mg2+, suggesting that it binds to the ATP-Mg2+-binding pocket of CDKs.	magnesium ion	96-100	cyclin dependent kinase 1	Homo sapiens	119-123
14767478-4	2004	We report here that reducing cyclin A expression by RNA interference (RNAi) in primary human fibroblasts inhibited activation of Cdc25B and Cdc25C and dephosphorylation of Cdk1 on tyrosine (tyr) 15.	Tyrosine	180-188	cyclin dependent kinase 1	Homo sapiens	172-176
15047157-7	2004	Taken together, harmine is a selective inhibitor of CDKs and cell proliferation.	Harmine	16-23	cyclin dependent kinase 1	Homo sapiens	52-56
14767478-4	2004	We report here that reducing cyclin A expression by RNA interference (RNAi) in primary human fibroblasts inhibited activation of Cdc25B and Cdc25C and dephosphorylation of Cdk1 on tyrosine (tyr) 15.	Tyrosine	180-183	cyclin dependent kinase 1	Homo sapiens	172-176
15059905-3	2004	Suppression of Mad2 and BubR1 in paclitaxel-treated cancer cells abolished checkpoint function, resulting in paclitaxel resistance that correlated with suppression of cyclin-dependent kinase-1 activity.	Paclitaxel	33-43	cyclin dependent kinase 1	Homo sapiens	167-192
14767478-6	2004	Cdk2-dn induction could inhibit Cdc25B activity and foster Cdk1 tyr phosphorylation within the S phase, temporally dissociating these events from Cdk1 activation at mitosis.	Tyrosine	64-67	cyclin dependent kinase 1	Homo sapiens	59-63
14968113-2	2004	Activation occurs by dephosphorylation of the inhibitory residues, threonine 14 (T14) and tyrosine 15 (Y15), on Cdc2 by the Cdc25C phosphatase.	Threonine	67-76	cyclin dependent kinase 1	Homo sapiens	112-116
14968113-2	2004	Activation occurs by dephosphorylation of the inhibitory residues, threonine 14 (T14) and tyrosine 15 (Y15), on Cdc2 by the Cdc25C phosphatase.	Tyrosine	90-98	cyclin dependent kinase 1	Homo sapiens	112-116
14645003-7	2004	Inhibiting JNK activation with SP600125 or D-JNKI1 peptide markedly reduced Bay/UCN-01-mediated mitochondrial dysfunction and apoptosis and the down-regulation of Mcl-1, XIAP, and Bcl-xL but not of cdc2/cdk1 activation.	pyrazolanthrone	31-39	cyclin dependent kinase 1	Homo sapiens	198-202
14645003-7	2004	Inhibiting JNK activation with SP600125 or D-JNKI1 peptide markedly reduced Bay/UCN-01-mediated mitochondrial dysfunction and apoptosis and the down-regulation of Mcl-1, XIAP, and Bcl-xL but not of cdc2/cdk1 activation.	pyrazolanthrone	31-39	cyclin dependent kinase 1	Homo sapiens	203-207
15059905-4	2004	In contrast, overexpression of Mad2 in cells with a checkpoint defect attributable to low Mad2 expression restored checkpoint function, resulting in enhanced paclitaxel sensitivity that correlated with enhanced cyclin-dependent kinase-1 activity.	Paclitaxel	158-168	cyclin dependent kinase 1	Homo sapiens	211-236
15001986-0	2004	Enhanced sensitivity to irinotecan by Cdk1 inhibition in the p53-deficient HT29 human colon cancer cell line.	Irinotecan	24-34	cyclin dependent kinase 1	Homo sapiens	38-42
15001986-9	2004	Cdk1 induction was exploited in vivo to improve the sensitivity to CPT-11 by additional treatment with the cdk-I CYC-202.	Irinotecan	67-73	cyclin dependent kinase 1	Homo sapiens	0-4
14975735-4	2004	Our data show that succinyl acetone-induced heme deficiency increases the protein levels of the tumor suppressor gene product p53 and CDK inhibitor p21, and decreases the protein levels of Cdk4, Cdc2, and cyclin D2.	succinylacetone	19-35	cyclin dependent kinase 1	Homo sapiens	195-199
15023361-4	2004	Rosco preferentially inhibits CDKs involved in cell cycle regulation (CDK1, 2, and 7) or neuronal functions (CDK5), whereas Flavo preferentially inhibits CDKs involved in cell cycle (CDK1, 2, 4, 7) or transcription (CDK7, and 9).	Roscovitine	0-5	cyclin dependent kinase 1	Homo sapiens	30-34
15023361-4	2004	Rosco preferentially inhibits CDKs involved in cell cycle regulation (CDK1, 2, and 7) or neuronal functions (CDK5), whereas Flavo preferentially inhibits CDKs involved in cell cycle (CDK1, 2, 4, 7) or transcription (CDK7, and 9).	Roscovitine	0-5	cyclin dependent kinase 1	Homo sapiens	70-74
15023361-4	2004	Rosco preferentially inhibits CDKs involved in cell cycle regulation (CDK1, 2, and 7) or neuronal functions (CDK5), whereas Flavo preferentially inhibits CDKs involved in cell cycle (CDK1, 2, 4, 7) or transcription (CDK7, and 9).	alvocidib	124-129	cyclin dependent kinase 1	Homo sapiens	154-158
14617691-1	2004	Xylocydine (4-amino-6-bromo-7-(beta-l-xylofuranosyl)pyrrolo[2,3-d]pyrimidine-5-carboxamide) blocks cyclin-dependent kinase CDK1 and CDK2/cyclin A activity in vitro (IC(50) 1.4 and 61 nM, respectively) while minimally inhibiting the three other Ser/Thr protein kinases tested (IC(50) 21-86 microM).	4-amino-6-bromo-7-(xylofuranosyl)pyrrolo(2,3-d)pyrimidine-5-carboxamide	0-10	cyclin dependent kinase 1	Homo sapiens	123-127
14627544-5	2004	On the other hand, treatments of a high concentration of Ca2+ ionophore or a low concentration of Ca2+ ionophore plus MEK inhibitor, U0126, linearly decreased MAP kinase activity following the decrease of p34cdc2 kinase activity; most of these oocytes formed pronuclei.	U 0126	133-138	cyclin dependent kinase 1	Homo sapiens	205-212
14726692-0	2004	Inhibition of cdk1 by alsterpaullone and thioflavopiridol correlates with increased transit time from mid G2 through prophase.	alsterpaullone	22-36	cyclin dependent kinase 1	Homo sapiens	14-18
14751090-3	2004	Flavopiridol exerts multiple effects in tumor cells, including inhibition of multiple CDKs, transcriptional inhibition secondary to disruption of P-TEFb (CDK9/cyclin T), induction of apoptosis, and antiangiogenesis.	alvocidib	0-12	cyclin dependent kinase 1	Homo sapiens	86-90
15043421-1	2004	A number of natural and synthetic flavonoids have been assessed previously with regard to their effects on the activity of cyclin-dependent kinases (Cdk1 and -2) related to the inhibition of cell cycle progression.	Flavonoids	34-44	cyclin dependent kinase 1	Homo sapiens	149-160
14617691-1	2004	Xylocydine (4-amino-6-bromo-7-(beta-l-xylofuranosyl)pyrrolo[2,3-d]pyrimidine-5-carboxamide) blocks cyclin-dependent kinase CDK1 and CDK2/cyclin A activity in vitro (IC(50) 1.4 and 61 nM, respectively) while minimally inhibiting the three other Ser/Thr protein kinases tested (IC(50) 21-86 microM).	4-amino-6-bromo-7-(beta-l-xylofuranosyl)pyrrolo[2,3-d]pyrimidine-5-carboxamide	12-90	cyclin dependent kinase 1	Homo sapiens	123-127
14990704-2	2004	Roscovitine (Rosco) is a purine derivative that inhibits cyclin-dependent kinase 1 (cdk1), cdk2, cdk5, cdk7, and cdk9, which are key regulators of the cell cycle and transcription.	Roscovitine	0-11	cyclin dependent kinase 1	Homo sapiens	57-82
15141722-5	2004	mRNA expression of cyclins A, B1, D1, E and CDKs 1, 2, 4, 6 in the presence of 10 ng/ml bFGF was generally greater in nifedipine responder cells than non-responder cells.	Nifedipine	118-128	cyclin dependent kinase 1	Homo sapiens	19-56
15141722-6	2004	These results indicate that nifedipine responder cells may be more susceptible to growth factors such as bFGF with a resultant increase in expression of cyclins and CDKs in responder compared with non-responder cells.	Nifedipine	28-38	cyclin dependent kinase 1	Homo sapiens	165-169
14990704-2	2004	Roscovitine (Rosco) is a purine derivative that inhibits cyclin-dependent kinase 1 (cdk1), cdk2, cdk5, cdk7, and cdk9, which are key regulators of the cell cycle and transcription.	Roscovitine	0-5	cyclin dependent kinase 1	Homo sapiens	57-82
14990704-2	2004	Roscovitine (Rosco) is a purine derivative that inhibits cyclin-dependent kinase 1 (cdk1), cdk2, cdk5, cdk7, and cdk9, which are key regulators of the cell cycle and transcription.	Roscovitine	0-11	cyclin dependent kinase 1	Homo sapiens	84-88
14990704-2	2004	Roscovitine (Rosco) is a purine derivative that inhibits cyclin-dependent kinase 1 (cdk1), cdk2, cdk5, cdk7, and cdk9, which are key regulators of the cell cycle and transcription.	Roscovitine	0-5	cyclin dependent kinase 1	Homo sapiens	84-88
14757171-8	2004	These findings suggest that the effect of genistein on G2/M arrest in HepG2 cells is partly due to ATM-dependent Chk2 activation, an increase in Cdc2 phosphorylation/inactivation as a result of induction of Wee1 expression, and a decrease in Cdc2 activity as a result of induction of p21waf1/cip1 expression.	Genistein	42-51	cyclin dependent kinase 1	Homo sapiens	145-149
14990704-2	2004	Roscovitine (Rosco) is a purine derivative that inhibits cyclin-dependent kinase 1 (cdk1), cdk2, cdk5, cdk7, and cdk9, which are key regulators of the cell cycle and transcription.	purine	25-31	cyclin dependent kinase 1	Homo sapiens	57-82
14990704-2	2004	Roscovitine (Rosco) is a purine derivative that inhibits cyclin-dependent kinase 1 (cdk1), cdk2, cdk5, cdk7, and cdk9, which are key regulators of the cell cycle and transcription.	purine	25-31	cyclin dependent kinase 1	Homo sapiens	84-88
14602088-3	2004	Roscovitine (10 microM), an antitumoral drug that inhibits cyclin-dependent kinase 1 (cdk1), cdk2 and cdk5, showed a significant neuroprotective effect on CGNs deprived of S/K.	Roscovitine	0-11	cyclin dependent kinase 1	Homo sapiens	59-84
14602088-3	2004	Roscovitine (10 microM), an antitumoral drug that inhibits cyclin-dependent kinase 1 (cdk1), cdk2 and cdk5, showed a significant neuroprotective effect on CGNs deprived of S/K.	Roscovitine	0-11	cyclin dependent kinase 1	Homo sapiens	86-90
14968433-8	2004	FTS, as well as suppressing cell growth, inhibited GF signaling pathway activity and reduced the levels of E2F1, p-Rb, and p-cdc2, all GF dependent mediators of cell-cycle progression.	farnesylthiosalicylic acid	0-3	cyclin dependent kinase 1	Homo sapiens	125-129
14757171-4	2004	Genistein also enhanced the expression of the cell cycle inhibitor, p21waf1/cip1, which interacts with Cdc2.	Genistein	0-9	cyclin dependent kinase 1	Homo sapiens	103-107
14757171-8	2004	These findings suggest that the effect of genistein on G2/M arrest in HepG2 cells is partly due to ATM-dependent Chk2 activation, an increase in Cdc2 phosphorylation/inactivation as a result of induction of Wee1 expression, and a decrease in Cdc2 activity as a result of induction of p21waf1/cip1 expression.	Genistein	42-51	cyclin dependent kinase 1	Homo sapiens	242-246
14726672-7	2004	Chk2 and Cdk1 phosphorylation and Cdc25C expression also differed between FN and polystyrene cultures.	Polystyrenes	81-92	cyclin dependent kinase 1	Homo sapiens	9-13
14698171-2	2004	Among the novel structures, 1-azakenpaullone was found to act as a selective GSK-3beta versus CDK1 inhibitor.	kenpaullone	28-44	cyclin dependent kinase 1	Homo sapiens	94-98
14724573-2	2004	However, treatment with TRAIL in combination with subtoxic doses of roscovitine, a specific inhibitor of Cdc2 and Cdk2, induced rapid apoptosis in TRAIL-resistant glioma cells.	Roscovitine	68-79	cyclin dependent kinase 1	Homo sapiens	105-109
14724573-4	2004	Treatment with roscovitine significantly inhibited Cdc2 activity, and expression of a dominant-negative Cdc2 mutant sensitized glioma cells to TRAIL-induced apoptosis.	Roscovitine	15-26	cyclin dependent kinase 1	Homo sapiens	51-55
14724573-6	2004	We found that treatment with roscovitine or expression of a dominant-negative Cdc2 mutant downregulated the protein levels of survivin and XIAP, two major caspase inhibitors.	Roscovitine	29-40	cyclin dependent kinase 1	Homo sapiens	78-82
14681206-3	2003	Cdc25A is required for S-phase entry and dephosphorylates tyrosine-15 phosphorylated Cdk1 (Cdc2) and Cdk2, positive regulators of cell division.	Tyrosine	58-66	cyclin dependent kinase 1	Homo sapiens	85-89
14695817-2	2004	The models are based on the kinase inhibition data of 52 paullone entities, which were aligned by a docking routine into the ATP-binding cleft of a CDK1/cyclin B homology model.	Adenosine Triphosphate	125-128	cyclin dependent kinase 1	Homo sapiens	148-152
15231455-6	2004	Moreover, preincubation of HT29 cells with roscovitine, a specific cdc2 kinase inhibitor, blocked the G2/M phase accumulation of HT29 cells treated with SFN and abolished its apoptotic effect (22.2 +/- 4 of floating cells in SFN-treated cells vs. 6.55 +/- 2 in cells treated with both SFN and roscovitine).	Roscovitine	43-54	cyclin dependent kinase 1	Homo sapiens	67-71
15231455-6	2004	Moreover, preincubation of HT29 cells with roscovitine, a specific cdc2 kinase inhibitor, blocked the G2/M phase accumulation of HT29 cells treated with SFN and abolished its apoptotic effect (22.2 +/- 4 of floating cells in SFN-treated cells vs. 6.55 +/- 2 in cells treated with both SFN and roscovitine).	sulforaphane	153-156	cyclin dependent kinase 1	Homo sapiens	67-71
15231455-9	2004	Inhibition of the cdc2 kinase by roscovitine did not change the phosphorylation status of Rb in SFN-treated cells, suggesting that this cyclin-dependent kinase may not be involved.	Roscovitine	33-44	cyclin dependent kinase 1	Homo sapiens	18-22
14551205-5	2003	Hamartin with alanine mutations in the three cyclin-dependent kinase 1 phosphorylation sites increased the inhibition of p70S6 kinase by the hamartin-tuberin complex.	Alanine	14-21	cyclin dependent kinase 1	Homo sapiens	45-70
14637187-6	2003	The interruption of cell cycle progression in the presence of thialysine was accompanied by a significant decline in the protein level of cdk4, cdk6, cdc2, cyclin A, cyclin B1, and cyclin E. These results demonstrate that the cytotoxic activity of thialysine toward Jurkat T cells is attributable to not only apoptotic cell death mediated by a mitochondria-dependent death signaling pathway, but also interruption of cell cycle progression by a massive down-regulation in the level of cdks and cyclins.	S-2-aminoethyl cysteine	62-72	cyclin dependent kinase 1	Homo sapiens	150-154
14637187-6	2003	The interruption of cell cycle progression in the presence of thialysine was accompanied by a significant decline in the protein level of cdk4, cdk6, cdc2, cyclin A, cyclin B1, and cyclin E. These results demonstrate that the cytotoxic activity of thialysine toward Jurkat T cells is attributable to not only apoptotic cell death mediated by a mitochondria-dependent death signaling pathway, but also interruption of cell cycle progression by a massive down-regulation in the level of cdks and cyclins.	S-2-aminoethyl cysteine	62-72	cyclin dependent kinase 1	Homo sapiens	485-489
14648095-11	2004	The expression of cdk1 and cdk2, important regulatory elements in the cell cycle, is downregulated following treatment with butyrate.	Butyrates	124-132	cyclin dependent kinase 1	Homo sapiens	18-22
14635192-5	2003	In the present study, we show that cdc2/CyB, a critical regulator of eukaryotic cell cycle progression, phosphorylates IP3R1 in vitro and in vivo at both Ser(421) and Thr(799) and that this phosphorylation increases IP3 binding.	Serine	154-157	cyclin dependent kinase 1	Homo sapiens	35-39
14635192-5	2003	In the present study, we show that cdc2/CyB, a critical regulator of eukaryotic cell cycle progression, phosphorylates IP3R1 in vitro and in vivo at both Ser(421) and Thr(799) and that this phosphorylation increases IP3 binding.	Threonine	167-170	cyclin dependent kinase 1	Homo sapiens	35-39
14635192-5	2003	In the present study, we show that cdc2/CyB, a critical regulator of eukaryotic cell cycle progression, phosphorylates IP3R1 in vitro and in vivo at both Ser(421) and Thr(799) and that this phosphorylation increases IP3 binding.	Inositol 1,4,5-Trisphosphate	119-122	cyclin dependent kinase 1	Homo sapiens	35-39
14681206-3	2003	Cdc25A is required for S-phase entry and dephosphorylates tyrosine-15 phosphorylated Cdk1 (Cdc2) and Cdk2, positive regulators of cell division.	Tyrosine	58-66	cyclin dependent kinase 1	Homo sapiens	0-4
14679005-5	2003	Coadministration of 17-AAG blocked SAHA-mediated induction of the cyclin-dependent kinase inhibitor p21(CIP1) and resulted in reduced expression of p27(KIP1) and p34(cdc2).	tanespimycin	20-26	cyclin dependent kinase 1	Homo sapiens	166-170
14679005-5	2003	Coadministration of 17-AAG blocked SAHA-mediated induction of the cyclin-dependent kinase inhibitor p21(CIP1) and resulted in reduced expression of p27(KIP1) and p34(cdc2).	Vorinostat	35-39	cyclin dependent kinase 1	Homo sapiens	166-170
14645578-10	2003	At late times, we observed accumulation of the Cdc25 phosphatases that remove the inhibitory phosphates from Cdk1.	Phosphates	93-103	cyclin dependent kinase 1	Homo sapiens	109-113
14645919-4	2003	A purified chimeric protein consisting of glutathione S-transferase (GST) fused to a domain of EBNA-LP containing Ser-35 was found to be specifically phosphorylated by purified cdc2 in vitro, while GST fused to a mutated domain of EBNA-LP in which Ser-35 was replaced with alanine was not.	Serine	114-117	cyclin dependent kinase 1	Homo sapiens	177-181
14645919-5	2003	In addition, overexpression of cdc2 in mammalian cells caused a significant increase in the phosphorylation of EBNA-LP, while this increased phosphorylation was eliminated if Ser-35 of EBNA-LP was replaced with alanine.	Serine	175-178	cyclin dependent kinase 1	Homo sapiens	31-35
14645919-5	2003	In addition, overexpression of cdc2 in mammalian cells caused a significant increase in the phosphorylation of EBNA-LP, while this increased phosphorylation was eliminated if Ser-35 of EBNA-LP was replaced with alanine.	Alanine	211-218	cyclin dependent kinase 1	Homo sapiens	31-35
14645919-6	2003	These results indicate that the cellular protein kinase cdc2 mediates the phosphorylation of EBNA-LP at Ser-35.	Serine	104-107	cyclin dependent kinase 1	Homo sapiens	56-60
14614451-5	2003	In other studies, we observed that G2/M arrest by silibinin was associated with a decrease in cdc25C, cdc2/p34 and cyclin B1 protein levels, as well as cdc2/p34 kinase activity.	Silybin	50-59	cyclin dependent kinase 1	Homo sapiens	94-98
14624373-3	2003	We found that, in concanavalin A-stimulated lymphocytes from HIV-infected patients, the inappropriate activation of the cyclin B1/p34 cdc2 kinase complex is temporally associated with increased threonine phosphorylation, augmented fragmentation, and prominent extranuclear and cell-surface localization of nucleolin.	Threonine	194-203	cyclin dependent kinase 1	Homo sapiens	134-138
14614451-5	2003	In other studies, we observed that G2/M arrest by silibinin was associated with a decrease in cdc25C, cdc2/p34 and cyclin B1 protein levels, as well as cdc2/p34 kinase activity.	Silybin	50-59	cyclin dependent kinase 1	Homo sapiens	102-106
12890733-0	2003	Effect of protein kinase C activator on mitogen-activated protein kinase and p34(cdc2) kinase activity during parthenogenetic activation of porcine oocytes by calcium ionophore.	Calcium	159-166	cyclin dependent kinase 1	Homo sapiens	81-85
12890733-10	2003	In conclusion, the parthenogenetic activation of porcine oocytes was mediated by the inactivation of p34(cdc2) kinase via a calcium-dependent pathway and thereafter by the inactivation of MAP kinase via a PKC-dependent pathway.	Calcium	124-131	cyclin dependent kinase 1	Homo sapiens	105-109
12958157-3	2003	Immunohistochemical analysis indicated that roscovitine-specific intracellular targets, CDK1, 2, 5, and 7, were expressed in the organ of Corti and especially in Hensen"s cells.	Roscovitine	44-55	cyclin dependent kinase 1	Homo sapiens	88-92
12958157-1	2003	In the embryonic day 19 organs of Corti, we showed that roscovitine, a chemical inhibitor of cyclin-dependent kinases (CDKs), significantly increased the number of hair cells (HCs) and corresponding supporting cells (SCs) by triggering differentiation of precursor cells without interacting with cell proliferation.	Roscovitine	56-67	cyclin dependent kinase 1	Homo sapiens	119-123
12958157-4	2003	Affinity chromatography studies showed a tight correlation between the protein levels of CDK1/2 and 5 and the rate of roscovitine-induced supernumerary cells in the organ of Corti.	Roscovitine	118-129	cyclin dependent kinase 1	Homo sapiens	89-101
12958157-2	2003	The effect of roscovitine was mimicked by other CDK1, 2, 5, and 7 inhibitors but not by CDK4/6 and mitogen-activated protein kinase pathway antagonists.	Roscovitine	14-25	cyclin dependent kinase 1	Homo sapiens	48-52
14550307-1	2003	SU9516 is a 3-substituted indolinone compound with demonstrated potent and selective inhibition toward cyclin dependent kinases (cdks).	SU 9516	0-6	cyclin dependent kinase 1	Homo sapiens	129-133
14560017-6	2003	We find that active RB mediates histone deacetylation on cyclin A, Cdc2, topoisomerase IIalpha, and thymidylate synthase promoters.	Rubidium	20-22	cyclin dependent kinase 1	Homo sapiens	67-71
14585987-3	2003	Furthermore, activation of p38alpha in MMR-proficient cells was associated with nuclear inactivation of the cell cycle regulator Cdc25C phosphatase and its downstream target Cdc2 and with activation of the G(2) checkpoint, actions which were suppressed by the p38alpha/beta inhibitors SB203580 and SB202590 or by expression of a p38alpha siRNA.	SB 203580	285-293	cyclin dependent kinase 1	Homo sapiens	129-133
14585987-3	2003	Furthermore, activation of p38alpha in MMR-proficient cells was associated with nuclear inactivation of the cell cycle regulator Cdc25C phosphatase and its downstream target Cdc2 and with activation of the G(2) checkpoint, actions which were suppressed by the p38alpha/beta inhibitors SB203580 and SB202590 or by expression of a p38alpha siRNA.	sb202590	298-306	cyclin dependent kinase 1	Homo sapiens	129-133
14550307-1	2003	SU9516 is a 3-substituted indolinone compound with demonstrated potent and selective inhibition toward cyclin dependent kinases (cdks).	3-substituted indolinone	12-36	cyclin dependent kinase 1	Homo sapiens	129-133
14550307-4	2003	Similarly, SU9516 inhibits cdk2/cyclin E and cdk1/cyclin B1 in an ATP-competitive manner, although at a 2- to 8-fold reduced potency.	SU 9516	11-17	cyclin dependent kinase 1	Homo sapiens	45-49
14550307-4	2003	Similarly, SU9516 inhibits cdk2/cyclin E and cdk1/cyclin B1 in an ATP-competitive manner, although at a 2- to 8-fold reduced potency.	Adenosine Triphosphate	66-69	cyclin dependent kinase 1	Homo sapiens	45-49
12973835-0	2003	ErbB2 overexpression in human breast carcinoma is correlated with p21Cip1 up-regulation and tyrosine-15 hyperphosphorylation of p34Cdc2: poor responsiveness to chemotherapy with cyclophoshamide methotrexate, and 5-fluorouracil is associated with Erb2 overexpression and with p21Cip1 overexpression.	cyclophoshamide methotrexate	178-206	cyclin dependent kinase 1	Homo sapiens	128-135
14521905-4	2003	TSA reduced the expression of cyclin B1, a key cyclin for G2-M transition, but stimulated expression of p21(WAF1/Cip1), an inhibitor of CDK and Cdc2.	trichostatin A	0-3	cyclin dependent kinase 1	Homo sapiens	144-148
14534529-4	2003	The amount of wee1 and c-Fos and the phosphorylation of cdc2 were decreased after treatment of the cells with an inhibitor of AP-1, curcumin.	Curcumin	132-140	cyclin dependent kinase 1	Homo sapiens	56-60
12941318-1	2003	A search among analogues of anti-CDK purines led to the identification of substituted pyrazolo[4,3-d]pyrimidines as novel inhibitors of CDK1/cyclin B.	Purines	37-44	cyclin dependent kinase 1	Homo sapiens	136-140
12941318-1	2003	A search among analogues of anti-CDK purines led to the identification of substituted pyrazolo[4,3-d]pyrimidines as novel inhibitors of CDK1/cyclin B.	pyrazolo[4,3-d]pyrimidines	86-112	cyclin dependent kinase 1	Homo sapiens	136-140
12941319-0	2003	2,6,8,9-tetrasubstituted purines as new CDK1 inhibitors.	2,6,8,9-tetrasubstituted	0-24	cyclin dependent kinase 1	Homo sapiens	40-44
12941319-0	2003	2,6,8,9-tetrasubstituted purines as new CDK1 inhibitors.	Purines	25-32	cyclin dependent kinase 1	Homo sapiens	40-44
12912980-6	2003	DNA damage by a radiomimetic drug or replication block by hydroxyurea stimulated a buildup of cyclin B1 but was accompanied by an increase of inhibitory phosphorylation of CDC2.	Hydroxyurea	58-69	cyclin dependent kinase 1	Homo sapiens	172-176
14562039-4	2003	In U937 cells, synergistic interactions between MG-132 and flavopiridol were associated with multiple perturbations in expression/activation of signaling- and survival-related proteins, including downregulation of XIAP and Mcl-1, activation of JNK and p34(cdc2), and diminished expression of p21(CIP1).	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	48-54	cyclin dependent kinase 1	Homo sapiens	256-260
14562039-4	2003	In U937 cells, synergistic interactions between MG-132 and flavopiridol were associated with multiple perturbations in expression/activation of signaling- and survival-related proteins, including downregulation of XIAP and Mcl-1, activation of JNK and p34(cdc2), and diminished expression of p21(CIP1).	alvocidib	59-71	cyclin dependent kinase 1	Homo sapiens	256-260
14519054-1	2003	BACKGROUND: Flavopiridol, a novel flavone derivative, inhibits cyclin-dependent kinase-1.	alvocidib	12-24	cyclin dependent kinase 1	Homo sapiens	63-88
14519054-1	2003	BACKGROUND: Flavopiridol, a novel flavone derivative, inhibits cyclin-dependent kinase-1.	flavone	34-41	cyclin dependent kinase 1	Homo sapiens	63-88
12941338-0	2003	Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2.	2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine	26-84	cyclin dependent kinase 1	Homo sapiens	99-131
12941338-1	2003	A series of O(4)-cyclohexylmethyl-5-nitroso-6-aminopyrimidines bearing 2-arylamino substituents was synthesised and evaluated for CDK1 and CDK2 inhibitory activity.	o(4)-cyclohexylmethyl-5-nitroso-6-aminopyrimidines	12-62	cyclin dependent kinase 1	Homo sapiens	130-134
12973835-5	2003	The underlying molecular mechanism is that ErbB2 inhibits p34(Cdc2) activation, which is required for taxol-induced apoptosis, by up-regulating p21(Cip1) and by hyperphosphorylating p34(Cdc2) on tyrosine-15.	Paclitaxel	102-107	cyclin dependent kinase 1	Homo sapiens	62-66
12973835-5	2003	The underlying molecular mechanism is that ErbB2 inhibits p34(Cdc2) activation, which is required for taxol-induced apoptosis, by up-regulating p21(Cip1) and by hyperphosphorylating p34(Cdc2) on tyrosine-15.	Paclitaxel	102-107	cyclin dependent kinase 1	Homo sapiens	186-190
12973835-5	2003	The underlying molecular mechanism is that ErbB2 inhibits p34(Cdc2) activation, which is required for taxol-induced apoptosis, by up-regulating p21(Cip1) and by hyperphosphorylating p34(Cdc2) on tyrosine-15.	Tyrosine	195-203	cyclin dependent kinase 1	Homo sapiens	62-66
12973835-0	2003	ErbB2 overexpression in human breast carcinoma is correlated with p21Cip1 up-regulation and tyrosine-15 hyperphosphorylation of p34Cdc2: poor responsiveness to chemotherapy with cyclophoshamide methotrexate, and 5-fluorouracil is associated with Erb2 overexpression and with p21Cip1 overexpression.	Fluorouracil	212-226	cyclin dependent kinase 1	Homo sapiens	128-135
12920193-8	2003	The neuroprotective and antiproliferative actions of cAMP, however, were closely mimicked by olomoucine and roscovitine, potent inhibitors of the cyclin-dependent kinase CDK1 that are structurally related to cAMP.	Cyclic AMP	53-57	cyclin dependent kinase 1	Homo sapiens	170-174
12963846-6	2003	IkappaBalphaM cells also displayed impairment in NaB- and PMA-mediated induction of p21CIP1 and phosphorylation (inactivation) of p34cdc2, as well as diminished levels of pRb-bound E2F1.	nab	49-52	cyclin dependent kinase 1	Homo sapiens	130-137
12963846-6	2003	IkappaBalphaM cells also displayed impairment in NaB- and PMA-mediated induction of p21CIP1 and phosphorylation (inactivation) of p34cdc2, as well as diminished levels of pRb-bound E2F1.	Tetradecanoylphorbol Acetate	58-61	cyclin dependent kinase 1	Homo sapiens	130-137
12920193-8	2003	The neuroprotective and antiproliferative actions of cAMP, however, were closely mimicked by olomoucine and roscovitine, potent inhibitors of the cyclin-dependent kinase CDK1 that are structurally related to cAMP.	olomoucine	93-103	cyclin dependent kinase 1	Homo sapiens	170-174
12920193-8	2003	The neuroprotective and antiproliferative actions of cAMP, however, were closely mimicked by olomoucine and roscovitine, potent inhibitors of the cyclin-dependent kinase CDK1 that are structurally related to cAMP.	Roscovitine	108-119	cyclin dependent kinase 1	Homo sapiens	170-174
12920193-8	2003	The neuroprotective and antiproliferative actions of cAMP, however, were closely mimicked by olomoucine and roscovitine, potent inhibitors of the cyclin-dependent kinase CDK1 that are structurally related to cAMP.	Cyclic AMP	208-212	cyclin dependent kinase 1	Homo sapiens	170-174
12920193-9	2003	Measurement of CDK1 activity confirmed that neuroprotection was closely correlated with inhibition of this kinase by cAMP.	Cyclic AMP	117-121	cyclin dependent kinase 1	Homo sapiens	15-19
12824044-1	2003	Structure-activity studies of 1H-pyrazolo[3,4-b]pyridine 1 have resulted in the discovery of potent CDK1/CDK2 selective inhibitor 21h, BMS-265246 (CDK1/cycB IC(50)=6 nM, CDK2/cycE IC(50)=9 nM).	1H-pyrazolo(3,4-b)pyridine	30-56	cyclin dependent kinase 1	Homo sapiens	100-104
12883482-6	2003	Immunoblot analysis revealed that ethanol metabolism had little affect on total Cdc2 content in these cells, but resulted in the accumulation of up to 20 times the amount of cyclin B1, indicating that cyclin B1 was available for formation of Cdc2/cyclin B1 complexes.	Ethanol	34-41	cyclin dependent kinase 1	Homo sapiens	242-246
12883482-7	2003	Co-immunoprecipitation revealed that 6 times more Cdc2/cyclin B1 complexes were present in the ethanol-treated cells compared with the controls.	Ethanol	95-102	cyclin dependent kinase 1	Homo sapiens	50-54
12883482-8	2003	Investigation of the phosphorylation state of Cdc2 revealed that ethanol oxidation increased the amount of the phosphorylated inactive form of Cdc2 by approximately 3-fold.	Ethanol	65-72	cyclin dependent kinase 1	Homo sapiens	46-50
12883482-8	2003	Investigation of the phosphorylation state of Cdc2 revealed that ethanol oxidation increased the amount of the phosphorylated inactive form of Cdc2 by approximately 3-fold.	Ethanol	65-72	cyclin dependent kinase 1	Homo sapiens	143-147
12883482-10	2003	In conclusion, ethanol oxidation by VA cells results in a G2/M cell-cycle arrest, mediated by accumulation of the phosphorylated inactive form of Cdc2.	Ethanol	15-22	cyclin dependent kinase 1	Homo sapiens	146-150
12883482-10	2003	In conclusion, ethanol oxidation by VA cells results in a G2/M cell-cycle arrest, mediated by accumulation of the phosphorylated inactive form of Cdc2.	Vanillic Acid	36-38	cyclin dependent kinase 1	Homo sapiens	146-150
12915131-6	2003	Aberrant levels of cyclin E and p21(Cip/WAF-1) expression as well as Cdc 2 phosphorylation at Tyrosine 15 suggest that perturbation of G1/S and G2/M transitions in cell cycle might be responsible for 5-FU triggered apoptosis.	Tyrosine	94-102	cyclin dependent kinase 1	Homo sapiens	69-74
12811820-6	2003	Caffeine induced G(2)/M phase cell cycle arrest in NB4 cells in association with the induction of phosphorylation at the Ser-15 residue of p53 and induction of tyrosine phosphorylation of cdc2.	Caffeine	0-8	cyclin dependent kinase 1	Homo sapiens	188-192
12811820-6	2003	Caffeine induced G(2)/M phase cell cycle arrest in NB4 cells in association with the induction of phosphorylation at the Ser-15 residue of p53 and induction of tyrosine phosphorylation of cdc2.	Tyrosine	160-168	cyclin dependent kinase 1	Homo sapiens	188-192
12811820-9	2003	These results suggest that caffeine induces cell cycle arrest and apoptosis in association with activation of p53 by a novel pathway to phosphorylate the Ser-15 residue and induction of phosphorylation of cdc 2 in leukemic cells with normal p53.	Caffeine	27-35	cyclin dependent kinase 1	Homo sapiens	205-210
12824044-1	2003	Structure-activity studies of 1H-pyrazolo[3,4-b]pyridine 1 have resulted in the discovery of potent CDK1/CDK2 selective inhibitor 21h, BMS-265246 (CDK1/cycB IC(50)=6 nM, CDK2/cycE IC(50)=9 nM).	1H-pyrazolo(3,4-b)pyridine	30-56	cyclin dependent kinase 1	Homo sapiens	147-151
12824044-1	2003	Structure-activity studies of 1H-pyrazolo[3,4-b]pyridine 1 have resulted in the discovery of potent CDK1/CDK2 selective inhibitor 21h, BMS-265246 (CDK1/cycB IC(50)=6 nM, CDK2/cycE IC(50)=9 nM).	21h	130-133	cyclin dependent kinase 1	Homo sapiens	100-104
12824044-1	2003	Structure-activity studies of 1H-pyrazolo[3,4-b]pyridine 1 have resulted in the discovery of potent CDK1/CDK2 selective inhibitor 21h, BMS-265246 (CDK1/cycB IC(50)=6 nM, CDK2/cycE IC(50)=9 nM).	21h	130-133	cyclin dependent kinase 1	Homo sapiens	147-151
12742231-5	2003	SAPK directly phosphorylated the cdc2 regulator, cdc25c, in vitro on serine 168 (S168).	Serine	69-75	cyclin dependent kinase 1	Homo sapiens	33-37
12835721-6	2003	(3) 1.5 mM caffeine that relieves cells from G(2)/M arrest also inhibits As(2)O(3)-induced Deltavarphi(m) collapse and apoptosis, (4) 1.0 micro M As(2)O(3) increases the expression of both cyclin B(1) and hCDC20 whereas it inhibits Tyr15 phosphorylation of p34(cdc2).	Caffeine	11-19	cyclin dependent kinase 1	Homo sapiens	261-265
12829999-8	2003	Consistent with these findings, both 15d-PGJ(2) and troglitazone significantly inhibited the G2/M cyclin-dependent kinase (CDK) Cdc2 activity.	Troglitazone	52-64	cyclin dependent kinase 1	Homo sapiens	128-132
12829999-8	2003	Consistent with these findings, both 15d-PGJ(2) and troglitazone significantly inhibited the G2/M cyclin-dependent kinase (CDK) Cdc2 activity.	15d-pgj	37-44	cyclin dependent kinase 1	Homo sapiens	128-132
12810701-6	2003	Now, we have found that p47, which mainly localizes to the nucleus during interphase, is phosphorylated on Serine-140 by Cdc2 at mitosis.	Serine	107-113	cyclin dependent kinase 1	Homo sapiens	121-125
12609978-6	2003	The mechanism of this uncoupling involves the cyclin B-Cdc2-dependent proteolytic cleavage of the N-terminal ERK-binding domain of MEK1 and the phosphorylation of Thr(286).	Threonine	163-166	cyclin dependent kinase 1	Homo sapiens	55-59
12813134-9	2003	Flavopiridol treatment of docetaxel-treated cells enhances the exit from mitosis with a more rapid decrease in mitotic markers including MPM-2 labeling and cyclin B1/cdc2 kinase activity.	alvocidib	0-12	cyclin dependent kinase 1	Homo sapiens	166-170
12813134-9	2003	Flavopiridol treatment of docetaxel-treated cells enhances the exit from mitosis with a more rapid decrease in mitotic markers including MPM-2 labeling and cyclin B1/cdc2 kinase activity.	Docetaxel	26-35	cyclin dependent kinase 1	Homo sapiens	166-170
12726921-3	2003	Exposure of cells to vanadate led to cell growth arrest at the G(2)/M phase and caused upregulation of p21 and phospho-cdc2 and degradation of cdc25C in a time- and dose-dependent manner.	Vanadates	21-29	cyclin dependent kinase 1	Homo sapiens	119-123
12726921-5	2003	PD98059, an inhibitor of ERK, and SB202190, an inhibitor of p38, inhibited vanadate-induced cell growth arrest, upregulation of p21 and cdc2, and degradation of cdc25C.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	cyclin dependent kinase 1	Homo sapiens	136-140
12726921-5	2003	PD98059, an inhibitor of ERK, and SB202190, an inhibitor of p38, inhibited vanadate-induced cell growth arrest, upregulation of p21 and cdc2, and degradation of cdc25C.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	34-42	cyclin dependent kinase 1	Homo sapiens	136-140
12726921-5	2003	PD98059, an inhibitor of ERK, and SB202190, an inhibitor of p38, inhibited vanadate-induced cell growth arrest, upregulation of p21 and cdc2, and degradation of cdc25C.	Vanadates	75-83	cyclin dependent kinase 1	Homo sapiens	136-140
12726921-8	2003	ROS activate ERK and p38, which in turn upregulate p21 and cdc2 and cause degradation of cdc25C, leading to cell growth arrest at the G(2)/M phase.	Reactive Oxygen Species	0-3	cyclin dependent kinase 1	Homo sapiens	59-63
12676925-10	2003	Moreover, Cdc25A overexpression abrogates the Chk1-mediated degradation and overcomes the doxorubicin-induced G2 arrest through dephosphorylation and activation of Cdc2/Cdk1 in a dose-dependent manner.	Doxorubicin	90-101	cyclin dependent kinase 1	Homo sapiens	10-14
12676925-10	2003	Moreover, Cdc25A overexpression abrogates the Chk1-mediated degradation and overcomes the doxorubicin-induced G2 arrest through dephosphorylation and activation of Cdc2/Cdk1 in a dose-dependent manner.	Doxorubicin	90-101	cyclin dependent kinase 1	Homo sapiens	169-173
12742823-4	2003	We report that HKa induced a significant upregulation of Cdc2 and cyclin A in proliferating endothelial cells, concurrent with a marked increase of Cdc2 activity.	3-methoxy-4-phenoxybenzoic acid	15-18	cyclin dependent kinase 1	Homo sapiens	57-61
12742823-4	2003	We report that HKa induced a significant upregulation of Cdc2 and cyclin A in proliferating endothelial cells, concurrent with a marked increase of Cdc2 activity.	3-methoxy-4-phenoxybenzoic acid	15-18	cyclin dependent kinase 1	Homo sapiens	148-152
12586835-4	2003	In mitotic HeLa cells, when the activity of Cdc2 is high, S6K1 is phosphorylated at multiple Ser/Thr, Pro (S/TP) sites, including Ser(371), Ser(411), Thr(421), and Ser(424).	Serine	93-96	cyclin dependent kinase 1	Homo sapiens	44-48
12586835-4	2003	In mitotic HeLa cells, when the activity of Cdc2 is high, S6K1 is phosphorylated at multiple Ser/Thr, Pro (S/TP) sites, including Ser(371), Ser(411), Thr(421), and Ser(424).	Threonine	97-100	cyclin dependent kinase 1	Homo sapiens	44-48
12586835-4	2003	In mitotic HeLa cells, when the activity of Cdc2 is high, S6K1 is phosphorylated at multiple Ser/Thr, Pro (S/TP) sites, including Ser(371), Ser(411), Thr(421), and Ser(424).	Proline	102-105	cyclin dependent kinase 1	Homo sapiens	44-48
12586835-4	2003	In mitotic HeLa cells, when the activity of Cdc2 is high, S6K1 is phosphorylated at multiple Ser/Thr, Pro (S/TP) sites, including Ser(371), Ser(411), Thr(421), and Ser(424).	neotetrazolium	109-111	cyclin dependent kinase 1	Homo sapiens	44-48
12586835-4	2003	In mitotic HeLa cells, when the activity of Cdc2 is high, S6K1 is phosphorylated at multiple Ser/Thr, Pro (S/TP) sites, including Ser(371), Ser(411), Thr(421), and Ser(424).	Serine	130-133	cyclin dependent kinase 1	Homo sapiens	44-48
12586835-4	2003	In mitotic HeLa cells, when the activity of Cdc2 is high, S6K1 is phosphorylated at multiple Ser/Thr, Pro (S/TP) sites, including Ser(371), Ser(411), Thr(421), and Ser(424).	Serine	130-133	cyclin dependent kinase 1	Homo sapiens	44-48
12586835-4	2003	In mitotic HeLa cells, when the activity of Cdc2 is high, S6K1 is phosphorylated at multiple Ser/Thr, Pro (S/TP) sites, including Ser(371), Ser(411), Thr(421), and Ser(424).	Threonine	150-153	cyclin dependent kinase 1	Homo sapiens	44-48
12586835-4	2003	In mitotic HeLa cells, when the activity of Cdc2 is high, S6K1 is phosphorylated at multiple Ser/Thr, Pro (S/TP) sites, including Ser(371), Ser(411), Thr(421), and Ser(424).	Serine	130-133	cyclin dependent kinase 1	Homo sapiens	44-48
12586835-7	2003	These proline-directed phosphorylations are sensitive to chemical inhibitors of Cdc2 but not to inhibitors of mammalian target of rapamycin, phosphatidylinositol 3-kinase, MEK1/2, or p38.	Proline	6-13	cyclin dependent kinase 1	Homo sapiens	80-84
12894503-3	2003	Caffeine, a nonspecific inhibitor of ATR, enhanced the cytotoxic effect of cisplatin, modestly decreased the p53 and p21WAF-1 response to cisplatin, and affected the cdc2-p34/cyclin B1 complex by decreasing both cyclin B1 protein accumulation and cdc2-p34 tyrosine 15 phosphorylation.	Tyrosine	256-264	cyclin dependent kinase 1	Homo sapiens	166-170
12663041-0	2003	Resveratrol-induced G2 arrest through the inhibition of CDK7 and p34CDC2 kinases in colon carcinoma HT29 cells.	Resveratrol	0-11	cyclin dependent kinase 1	Homo sapiens	65-72
12646262-8	2003	The addition of butyrolactone I, which is an inhibitor of CDK1 and CDK2, to the p53-negative cells reduced the floating round cell population and induced the disappearance of cyclin B1.	4-Butyrolactone	16-29	cyclin dependent kinase 1	Homo sapiens	58-62
12663041-7	2003	In addition, resveratrol-treated cells were shown to have a low level of CDK7 kinase-Thr(161)-phosphorylated p34(CDC2).	Threonine	85-88	cyclin dependent kinase 1	Homo sapiens	113-117
12894503-3	2003	Caffeine, a nonspecific inhibitor of ATR, enhanced the cytotoxic effect of cisplatin, modestly decreased the p53 and p21WAF-1 response to cisplatin, and affected the cdc2-p34/cyclin B1 complex by decreasing both cyclin B1 protein accumulation and cdc2-p34 tyrosine 15 phosphorylation.	Caffeine	0-8	cyclin dependent kinase 1	Homo sapiens	166-170
12894503-3	2003	Caffeine, a nonspecific inhibitor of ATR, enhanced the cytotoxic effect of cisplatin, modestly decreased the p53 and p21WAF-1 response to cisplatin, and affected the cdc2-p34/cyclin B1 complex by decreasing both cyclin B1 protein accumulation and cdc2-p34 tyrosine 15 phosphorylation.	Caffeine	0-8	cyclin dependent kinase 1	Homo sapiens	247-251
12721754-5	2003	However, pRb was dephosphorylated and cdc2 was inhibited at both the low and the high concentrations of staurosporine, indicating that the mechanisms of cell cycle regulation are not simply p53-Rb- or cdc2-dependent pathways.	Staurosporine	104-117	cyclin dependent kinase 1	Homo sapiens	38-42
12663041-5	2003	Western blot analysis and kinase assays demonstrated that the perturbation of G(2) phase progression by resveratrol was accompanied by the inactivation of p34(CDC2) protein kinase, and an increase in the tyrosine phosphorylated (inactive) form of p34(CDC2).	Resveratrol	104-115	cyclin dependent kinase 1	Homo sapiens	159-163
12663041-5	2003	Western blot analysis and kinase assays demonstrated that the perturbation of G(2) phase progression by resveratrol was accompanied by the inactivation of p34(CDC2) protein kinase, and an increase in the tyrosine phosphorylated (inactive) form of p34(CDC2).	Resveratrol	104-115	cyclin dependent kinase 1	Homo sapiens	251-255
12663041-6	2003	Kinase assays revealed that the reduction of p34(CDC2) activity by resveratrol was mediated through the inhibition of CDK7 kinase activity, while CDC25A phosphatase activity was not affected.	Resveratrol	67-78	cyclin dependent kinase 1	Homo sapiens	49-53
12663041-7	2003	In addition, resveratrol-treated cells were shown to have a low level of CDK7 kinase-Thr(161)-phosphorylated p34(CDC2).	Resveratrol	13-24	cyclin dependent kinase 1	Homo sapiens	113-117
12669309-5	2003	The inhibitory phosphorylation of CDC2 on Tyr-15 was significantly elevated at 12-24 h, and its levels gradually declined during G2 arrest in Hep3B.	Tyrosine	42-45	cyclin dependent kinase 1	Homo sapiens	34-38
12690294-7	2003	Western blot analysis of the G(2)/M regulatory proteins suggests that cdc2 is involved in the cell cycle block by Myt1 phosphorylation following 2-ME treatment.	2-Methoxyestradiol	145-149	cyclin dependent kinase 1	Homo sapiens	70-74
12669309-6	2003	In particular, augmentation of CDK inhibitors p21cip1 and p27kip1 and Wee1 kinase and diminution of CDC25C phosphatase coincided with induced Tyr-15 phosphorylation and inhibition of CDC2.	Tyrosine	142-145	cyclin dependent kinase 1	Homo sapiens	100-104
12650433-5	2003	In MGMT-depleted cells, TMZ exposure led to DNA single-strand breaks and phosphorylation of cdc2, followed by G2-M arrest, induction of p53/p21, and DNA double-strand breaks.	Temozolomide	24-27	cyclin dependent kinase 1	Homo sapiens	92-96
12643928-1	2003	1H-Pyrazolo[3,4-b]pyridine 3 (SQ-67563) has been shown to be a potent, selective inhibitor of CDK1/CDK2 in vitro.	1h-pyrazolo[3,4-b]pyridine 3	0-28	cyclin dependent kinase 1	Homo sapiens	94-98
12643928-1	2003	1H-Pyrazolo[3,4-b]pyridine 3 (SQ-67563) has been shown to be a potent, selective inhibitor of CDK1/CDK2 in vitro.	SQ-67563	30-38	cyclin dependent kinase 1	Homo sapiens	94-98
12593668-0	2003	Evaluation of the first cytostatically active 1-aza-9-oxafluorenes as novel selective CDK1 inhibitors with P-glycoprotein modulating properties.	1-aza-9-oxafluorenes	46-66	cyclin dependent kinase 1	Homo sapiens	86-90
12593668-1	2003	The first series of synthetic 1-aza-9-oxafluorenes with cytostatic activities in the micromolar range was evaluated as cyclin-dependent kinase (CDK1) inhibitors.	1-aza-9-oxafluorenes	30-50	cyclin dependent kinase 1	Homo sapiens	144-148
12591724-4	2003	Furthermore, increased Cdc25B expression and decreased Cdk1 phosphorylation were observed in anti-BPDE-treated cells.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	98-102	cyclin dependent kinase 1	Homo sapiens	55-59
12569391-4	2003	The increased sensitivity to etoposide-induced G(2)-M arrest was associated with disruption of cell cycle-related events, including hyperphosphorylation of p34(cdc2) kinase, change in cdc25C expression and phosphorylation, and alteration in cyclin B1 expression.	Etoposide	29-38	cyclin dependent kinase 1	Homo sapiens	160-164
12468530-4	2003	One of the identified phosphorylated serines, Ser-90, was within a consensus cyclin B/Cdc2 site.	Serine	37-44	cyclin dependent kinase 1	Homo sapiens	86-90
12468530-4	2003	One of the identified phosphorylated serines, Ser-90, was within a consensus cyclin B/Cdc2 site.	Serine	46-49	cyclin dependent kinase 1	Homo sapiens	86-90
12468530-5	2003	Ser-90 was specifically phosphorylated in vitro by the cyclin B/Cdc2 complex.	Serine	0-3	cyclin dependent kinase 1	Homo sapiens	64-68
12556484-5	2003	Nudel was specifically phosphorylated in M phase in its serine/threonine phosphorylation motifs, probably by Cdc2 and also Erk1 and -2.	Serine	56-62	cyclin dependent kinase 1	Homo sapiens	109-113
12551973-7	2003	(iv) The sequence flanking Ser-133 of EF-1delta completely matches the consensus phosphorylation site for a cellular protein kinase, cdc2, and in vitro kinase assays revealed that purified cdc2 phosphorylates Ser-133 of EF-1delta.	Serine	27-30	cyclin dependent kinase 1	Homo sapiens	133-137
12551973-7	2003	(iv) The sequence flanking Ser-133 of EF-1delta completely matches the consensus phosphorylation site for a cellular protein kinase, cdc2, and in vitro kinase assays revealed that purified cdc2 phosphorylates Ser-133 of EF-1delta.	Serine	27-30	cyclin dependent kinase 1	Homo sapiens	189-193
12551973-7	2003	(iv) The sequence flanking Ser-133 of EF-1delta completely matches the consensus phosphorylation site for a cellular protein kinase, cdc2, and in vitro kinase assays revealed that purified cdc2 phosphorylates Ser-133 of EF-1delta.	Serine	209-212	cyclin dependent kinase 1	Homo sapiens	133-137
12551973-7	2003	(iv) The sequence flanking Ser-133 of EF-1delta completely matches the consensus phosphorylation site for a cellular protein kinase, cdc2, and in vitro kinase assays revealed that purified cdc2 phosphorylates Ser-133 of EF-1delta.	Serine	209-212	cyclin dependent kinase 1	Homo sapiens	189-193
12556484-5	2003	Nudel was specifically phosphorylated in M phase in its serine/threonine phosphorylation motifs, probably by Cdc2 and also Erk1 and -2.	Threonine	63-72	cyclin dependent kinase 1	Homo sapiens	109-113
12678910-2	2003	In our laboratories, a variety of selective and potent low molecular weight inhibitors directed against the ATP binding sites of the Cdk1, Cdk2 have been developed.	Adenosine Triphosphate	108-111	cyclin dependent kinase 1	Homo sapiens	133-137
12697104-8	2003	Upon irradiation, p34cdc2 in U937-pZEOSV2 (+) was in an inactive state owing to phosphorylation of Thr 14 and Tyr15, which was associated with a dramatic decrease of nuclear cdc25A, cdc25B and cdc25C poteins.	Threonine	99-102	cyclin dependent kinase 1	Homo sapiens	18-25
12519061-5	2003	A selectivity study performed on 26 kinases shows that aloisine A is highly selective for CDK1/cyclin B, CDK2/cyclin A-E, CDK5/p25, and GSK-3 alpha/beta; the two latter enzymes have been implicated in Alzheimer"s disease.	7-n-butyl-6-(4'-hydroxyphenyl)-5H-pyrrolo(2,3b)pyrazine	55-65	cyclin dependent kinase 1	Homo sapiens	90-94
12482427-0	2003	4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2.	4-alkoxy-2,6-diaminopyrimidine	0-30	cyclin dependent kinase 1	Homo sapiens	58-90
12482427-6	2003	However, the derivative bearing an isosteric 5-formyl group, 2,6-diamino-4-cyclohexylmethoxy-pyrimidine-5-carbaldehyde, showed modest activity (IC(50) vs cdk1/cyclinB1=35+/-3 microM and cdk2/cyclinA3=43+/-3 microM).	2,6-diamino-4-cyclohexylmethoxy-pyrimidine-5-carbaldehyde	61-118	cyclin dependent kinase 1	Homo sapiens	154-158
12450396-4	2002	We now show that N-terminal to the NLS domain of pro-IL-16 are protein kinase CK2 substrate and cdc2 kinase substrate sites which, along with the NLS, constitute a dual phosphorylation-regulated CcN motif which regulates nuclear localization of pro-IL-16.	acetonitrile	195-198	cyclin dependent kinase 1	Homo sapiens	96-100
12514295-2	2003	We recently reported that genistein treatment of the immortalized but nonmalignant human mammary epithelial cell line MCF-10F resulted in growth arrest of MCF-10F cells in the G2 phase of the cell cycle, a large induction of the Tyr15 phosphorylation of Cdc2 (along with decreased activity of Cdc2), increased expression of p21(waf/cip1) and decreased expression of the cell cycle phosphatase Cdc25C.	Genistein	26-35	cyclin dependent kinase 1	Homo sapiens	254-258
12514295-2	2003	We recently reported that genistein treatment of the immortalized but nonmalignant human mammary epithelial cell line MCF-10F resulted in growth arrest of MCF-10F cells in the G2 phase of the cell cycle, a large induction of the Tyr15 phosphorylation of Cdc2 (along with decreased activity of Cdc2), increased expression of p21(waf/cip1) and decreased expression of the cell cycle phosphatase Cdc25C.	Genistein	26-35	cyclin dependent kinase 1	Homo sapiens	293-297
12514295-4	2003	We also showed that p38 is involved in genistein-induced changes in Cdc2 phosphorylation and that the downregulation of Cdc25C expression by genistein is through the p38 pathway.	Genistein	39-48	cyclin dependent kinase 1	Homo sapiens	68-72
12397081-4	2002	It is shown here that activation of p34(cdc2) kinase (cdc2) with okadaic acid is correlated with hyperphosphorylation of Gro/TLEs.	Okadaic Acid	65-77	cyclin dependent kinase 1	Homo sapiens	40-44
12472573-4	2002	There was no predicted cell cycle arrest in Bcr-abl-positive derivative cell lines of K562 that did not survive the same genotoxic insult but, paradoxically, Cdk1 tyrosine phosphorylation was enhanced to a higher extent compared with the parental cell line where arrest of the cell cycle was observed.	Tyrosine	163-171	cyclin dependent kinase 1	Homo sapiens	158-162
12472573-6	2002	Only HL60 cells that subsequently underwent apoptosis elicited the same effect of increased Cdk1 tyrosine phosphorylation.	Tyrosine	97-105	cyclin dependent kinase 1	Homo sapiens	92-96
12472573-2	2002	Arrest of the cell cycle is mediated by retaining an inactivating state of phosphorylation of cyclin-dependent kinase 1 (Cdk1) on tyrosine 15.	Tyrosine	130-138	cyclin dependent kinase 1	Homo sapiens	94-119
12472573-7	2002	It is proposed that the augmented tyrosine phosphorylation status of Cdk1 is associated with the abolition of cell survival, in addition to the previously reported induction of cell cycle arrest in myeloid cell lines.	Tyrosine	34-42	cyclin dependent kinase 1	Homo sapiens	69-73
12472573-2	2002	Arrest of the cell cycle is mediated by retaining an inactivating state of phosphorylation of cyclin-dependent kinase 1 (Cdk1) on tyrosine 15.	Tyrosine	130-138	cyclin dependent kinase 1	Homo sapiens	121-125
12429981-5	2002	At 24 h after the administration of catechin, the phosphorylation of cell division cycle 2 (cdc2) was inhibited, and the expression of cyclin B1 protein was also decreased.	Catechin	36-44	cyclin dependent kinase 1	Homo sapiens	69-90
12478465-4	2002	This applies to several clinically important settings, for instance to paclitaxel-induced killing of breast cancer cells, in which the ErbB2 receptor kinase can mediate apoptosis inhibition through inactivation of Cdk1.	Paclitaxel	71-81	cyclin dependent kinase 1	Homo sapiens	214-218
12429981-5	2002	At 24 h after the administration of catechin, the phosphorylation of cell division cycle 2 (cdc2) was inhibited, and the expression of cyclin B1 protein was also decreased.	Catechin	36-44	cyclin dependent kinase 1	Homo sapiens	92-96
12429981-8	2002	Based on these results, we speculate that, in the breast cancer cell line T47D, catechin phosphorylated JNK/SAPK and p38, and that the phosphorylated JNK/SAPK and p38 inhibited the phosphorylation of cdc2, and regulated the expression of cyclin A, cyclin B1, and cdk proteins, thereby causing G2 arrest.	Catechin	80-88	cyclin dependent kinase 1	Homo sapiens	200-204
12447691-2	2002	Phosphorylation of four serine residues within cyclin B1 promotes the rapid nuclear translocation of Cdc2/cyclin B1 at the G(2)/M transition.	Serine	24-30	cyclin dependent kinase 1	Homo sapiens	101-105
12392733-1	2002	Based on our previous experiences with synthesis of purines, novel 2,6,9-trisubstituted purine derivatives were prepared and assayed for the ability to inhibit CDK1/cyclin B kinase.	Purines	52-59	cyclin dependent kinase 1	Homo sapiens	160-164
12392733-1	2002	Based on our previous experiences with synthesis of purines, novel 2,6,9-trisubstituted purine derivatives were prepared and assayed for the ability to inhibit CDK1/cyclin B kinase.	2,6,9-trisubstituted	67-87	cyclin dependent kinase 1	Homo sapiens	160-164
12392733-1	2002	Based on our previous experiences with synthesis of purines, novel 2,6,9-trisubstituted purine derivatives were prepared and assayed for the ability to inhibit CDK1/cyclin B kinase.	purine	52-58	cyclin dependent kinase 1	Homo sapiens	160-164
12392733-2	2002	One of newly synthesized compounds designated as olomoucine II, 6-[(2-hydroxybenzyl)amino]-2-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine, displays 10 times higher inhibitory activity than roscovitine, potent and specific CDK1 inhibitor.	olomoucine II	49-62	cyclin dependent kinase 1	Homo sapiens	228-232
12392733-2	2002	One of newly synthesized compounds designated as olomoucine II, 6-[(2-hydroxybenzyl)amino]-2-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine, displays 10 times higher inhibitory activity than roscovitine, potent and specific CDK1 inhibitor.	6-[(2-hydroxybenzyl)amino]-2-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine	64-143	cyclin dependent kinase 1	Homo sapiens	228-232
12642693-5	2002	Coadminstration of UCN-01 with U0126 produced multiple perturbations in signal transduction/cell cycle regulatory pathways, including diminished expression of Bcr/Abl, Mcl-1, cylin D(1), and activation of JNK and p34(cdc2).	U 0126	31-36	cyclin dependent kinase 1	Homo sapiens	217-221
12384528-5	2002	Herceptin plus Taxol treatment led to higher levels of p34(Cdc2) kinase activity and apoptosis in ErbB2-overexpressing breast cancer cells, which is likely attributable to inhibition of Cdc2-Tyr-15 phosphorylation and p21(Cip1) expression.	Paclitaxel	15-20	cyclin dependent kinase 1	Homo sapiens	186-190
12384528-4	2002	Herceptin treatment down-regulated ErbB2, reduced the inhibitory phosphorylation of Cdc2 on Tyr-15, and down-regulated the expression of p21(Cip1), a Cdc2 inhibitor.	Tyrosine	92-95	cyclin dependent kinase 1	Homo sapiens	84-88
12384528-5	2002	Herceptin plus Taxol treatment led to higher levels of p34(Cdc2) kinase activity and apoptosis in ErbB2-overexpressing breast cancer cells, which is likely attributable to inhibition of Cdc2-Tyr-15 phosphorylation and p21(Cip1) expression.	Tyrosine	191-194	cyclin dependent kinase 1	Homo sapiens	186-190
12384528-5	2002	Herceptin plus Taxol treatment led to higher levels of p34(Cdc2) kinase activity and apoptosis in ErbB2-overexpressing breast cancer cells, which is likely attributable to inhibition of Cdc2-Tyr-15 phosphorylation and p21(Cip1) expression.	Paclitaxel	15-20	cyclin dependent kinase 1	Homo sapiens	59-63
12384528-6	2002	Because significant dephosphorylation of Cdc2-Tyr-15 and down-regulation of p21(Cip1) occur at least 24 h after Herceptin treatment, we investigated whether 24 h Herceptin pretreatment will render ErbB2-overexpressing breast cancer cells more sensitive to Taxol-induced apoptosis compared with the simultaneous treatment of Herceptin plus Taxol.	Tyrosine	46-49	cyclin dependent kinase 1	Homo sapiens	41-45
12384528-8	2002	Thus, Herceptin treatment of ErbB2-overexpressing cells can inhibit ErbB2-mediated Cdc2-Tyr-15 phosphorylation and p21(Cip1) up-regulation, which allows effective p34(Cdc2) activation and induction of apoptosis upon Taxol treatment.	Tyrosine	88-91	cyclin dependent kinase 1	Homo sapiens	83-87
12384528-8	2002	Thus, Herceptin treatment of ErbB2-overexpressing cells can inhibit ErbB2-mediated Cdc2-Tyr-15 phosphorylation and p21(Cip1) up-regulation, which allows effective p34(Cdc2) activation and induction of apoptosis upon Taxol treatment.	Paclitaxel	216-221	cyclin dependent kinase 1	Homo sapiens	83-87
12372407-3	2002	The structural model indicates that roscovitine strongly binds to the ATP-binding pocket of CDK5 and structural comparison of the CDK2-roscovitine complex correlates the structural differences with differences in inhibition of these CDKs by this inhibitor.	Roscovitine	135-146	cyclin dependent kinase 1	Homo sapiens	233-237
12372407-2	2002	Roscovitine has been shown to potently inhibit cyclin-dependent kinases 1, 2 and 5 (CDK1, 2, and 5), and the structure of CDK2 complexed with roscovitine has been reported; however, no structural data are available for complexes of CDK5 with inhibitors.	Roscovitine	0-11	cyclin dependent kinase 1	Homo sapiens	47-82
12372407-2	2002	Roscovitine has been shown to potently inhibit cyclin-dependent kinases 1, 2 and 5 (CDK1, 2, and 5), and the structure of CDK2 complexed with roscovitine has been reported; however, no structural data are available for complexes of CDK5 with inhibitors.	Roscovitine	0-11	cyclin dependent kinase 1	Homo sapiens	84-98
12372407-3	2002	The structural model indicates that roscovitine strongly binds to the ATP-binding pocket of CDK5 and structural comparison of the CDK2-roscovitine complex correlates the structural differences with differences in inhibition of these CDKs by this inhibitor.	Roscovitine	36-47	cyclin dependent kinase 1	Homo sapiens	233-237
12101183-0	2002	Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis.	hypericin	90-99	cyclin dependent kinase 1	Homo sapiens	111-115
12372407-3	2002	The structural model indicates that roscovitine strongly binds to the ATP-binding pocket of CDK5 and structural comparison of the CDK2-roscovitine complex correlates the structural differences with differences in inhibition of these CDKs by this inhibitor.	Adenosine Triphosphate	70-73	cyclin dependent kinase 1	Homo sapiens	233-237
12171907-8	2002	Exposure of WSU-CLL cells to 4 and 5 nM CA4P was associated with overproduction of total p53 and no dramatic change in MDM2, 14-3-3sigma, GADD45, the cyclin-dependent kinase cdc2, its inhibitory phosphorylation, the cdc2-inhibitory kinase (wee1), chk1, or cdc25 hyperphosphorylation.	CA4P	40-44	cyclin dependent kinase 1	Homo sapiens	174-178
12244298-2	2002	Iterative structure-based design was used to optimize the ATP- competitive inhibition of CDK1 and CDK2 by O(6)-cyclohexylmethylguanines, resulting in O(6)-cyclohexylmethyl-2-(4"- sulfamoylanilino)purine.	Adenosine Triphosphate	58-61	cyclin dependent kinase 1	Homo sapiens	89-93
12244298-2	2002	Iterative structure-based design was used to optimize the ATP- competitive inhibition of CDK1 and CDK2 by O(6)-cyclohexylmethylguanines, resulting in O(6)-cyclohexylmethyl-2-(4"- sulfamoylanilino)purine.	NU2058	106-135	cyclin dependent kinase 1	Homo sapiens	89-93
12244298-2	2002	Iterative structure-based design was used to optimize the ATP- competitive inhibition of CDK1 and CDK2 by O(6)-cyclohexylmethylguanines, resulting in O(6)-cyclohexylmethyl-2-(4"- sulfamoylanilino)purine.	o(6)-cyclohexylmethyl-2-(4"- sulfamoylanilino)purine	150-202	cyclin dependent kinase 1	Homo sapiens	89-93
12244298-3	2002	The new inhibitor is 1,000-fold more potent than the parent compound (K(i) values for CDK1 = 9 nM and CDK2 = 6 nM versus 5,000 nM and 12,000 nM, respectively, for O(6)-cyclohexylmethylguanine).	NU2058	163-191	cyclin dependent kinase 1	Homo sapiens	86-90
12107172-4	2002	We also show that serine 146 is phosphorylated in vitro by CDK1-cyclin B.	Serine	18-24	cyclin dependent kinase 1	Homo sapiens	59-63
12121920-0	2002	Inhibition of cyclin-dependent kinase 1 by purines and pyrrolo[2,3-d]pyrimidines does not correlate with antiviral activity.	Purines	43-50	cyclin dependent kinase 1	Homo sapiens	14-39
12121920-4	2002	Much higher concentrations of a panel of pyrrolo[2,3-d]pyrimidine nucleoside analogs with antiviral activity were required to inhibit recombinant cdk1/cyclin B compared to the submicromolar concentrations required to inhibit HCMV and HSV-1 replication.	pyrrolo[2,3-d]pyrimidine nucleoside	41-76	cyclin dependent kinase 1	Homo sapiens	146-150
12121920-5	2002	4,6-Diamino-5-cyano-7-(2-phenylethyl)pyrrolo[2,3-d]pyrimidine (compound 1369) was the best inhibitor of cdk1 and cyclin B, with a 50% inhibitory concentration (IC(50); 14 microM) similar to that of roscovitine; it was competitive with respect to ATP (K(i) = 14 microM).	4,6-diamino-5-cyano-7-(2-phenylethyl)pyrrolo[2,3-d]pyrimidine	0-61	cyclin dependent kinase 1	Homo sapiens	104-108
12121920-10	2002	Therefore, we propose that inhibition of cdk1 and cyclin B is not responsible for selective antiviral activity and that pyrrolo[2,3-d]pyrimidines constitute novel pharmacophores which compete with ATP to inhibit cdk1 and cyclin B.	Pyrrolo(2,3-d)pyrimidine	120-145	cyclin dependent kinase 1	Homo sapiens	212-216
12226745-12	2002	When cells were treated with purvalanol, p42/p44 MAPK and CDK1 activities were inhibited in a dose-dependent manner.	purvalanol B	29-39	cyclin dependent kinase 1	Homo sapiens	58-62
12226745-14	2002	We conclude that the anti-proliferative properties of purvalanol are mediated by inhibition of both p42/p44 MAPK and CDKs.	purvalanol B	54-64	cyclin dependent kinase 1	Homo sapiens	117-121
12154027-11	2002	DNA microarray analysis of livers from ET-743-treated animals showed a dramatic increase in the expression of ATP binding cassette transport genes Abcb1a and Abcb1b, which impart resistance to anticancer drugs, and of Cdc2a and Ccnd1, the rodent homologues of human cell cycle genes CDC2 and cyclin D1, respectively.	Trabectedin	39-45	cyclin dependent kinase 1	Homo sapiens	283-287
12154027-11	2002	DNA microarray analysis of livers from ET-743-treated animals showed a dramatic increase in the expression of ATP binding cassette transport genes Abcb1a and Abcb1b, which impart resistance to anticancer drugs, and of Cdc2a and Ccnd1, the rodent homologues of human cell cycle genes CDC2 and cyclin D1, respectively.	Adenosine Triphosphate	110-113	cyclin dependent kinase 1	Homo sapiens	283-287
12171907-8	2002	Exposure of WSU-CLL cells to 4 and 5 nM CA4P was associated with overproduction of total p53 and no dramatic change in MDM2, 14-3-3sigma, GADD45, the cyclin-dependent kinase cdc2, its inhibitory phosphorylation, the cdc2-inhibitory kinase (wee1), chk1, or cdc25 hyperphosphorylation.	CA4P	40-44	cyclin dependent kinase 1	Homo sapiens	216-220
12171907-10	2002	Our findings suggest that CA4P induces mitotic catastrophe and arrest of WSU-CLL cells mostly in the M phase independent of p53 and independent of chk1 and cdc2 phosphorylation pathways.	CA4P	26-30	cyclin dependent kinase 1	Homo sapiens	156-160
12119558-6	2002	During this inhibition process, resveratrol increases the content of cyclins A and B1 as well as cyclin-dependent kinases Cdk1 and Cdk2.	Resveratrol	32-43	cyclin dependent kinase 1	Homo sapiens	122-126
12119558-7	2002	Moreover, resveratrol promotes Cdk1 phosphorylation.	Resveratrol	10-21	cyclin dependent kinase 1	Homo sapiens	31-35
12139449-1	2002	O(6)-substituted guanines are adenosine 5"-triphosphate (ATP) competitive inhibitors of CDK1/cyclin B1 and CDK2/cyclin A, the O(6) substituent occupying the kinase ribose binding site.	Adenosine Triphosphate	57-60	cyclin dependent kinase 1	Homo sapiens	88-92
12139449-0	2002	Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives.	Adenosine Triphosphate	12-15	cyclin dependent kinase 1	Homo sapiens	41-73
12118331-5	2002	Despite failing to enhance apoptosis, UCN-01 treatment abrogated IR-induced G2/M arrest in both cell lines, an event associated with enhanced activation of cyclin-dependent kinase 1 (cdk1), promotion of G0/G1 arrest, and dephosphorylation of the retinoblastoma protein (pRb).	7-hydroxystaurosporine	38-44	cyclin dependent kinase 1	Homo sapiens	156-181
12118331-5	2002	Despite failing to enhance apoptosis, UCN-01 treatment abrogated IR-induced G2/M arrest in both cell lines, an event associated with enhanced activation of cyclin-dependent kinase 1 (cdk1), promotion of G0/G1 arrest, and dephosphorylation of the retinoblastoma protein (pRb).	7-hydroxystaurosporine	38-44	cyclin dependent kinase 1	Homo sapiens	183-187
12118335-3	2002	Curcumin was found to induce G0/G1 and/or G2/M phase cell cycle arrest, up-regulate CDKIs, p21WAF1/CIP1, p27KIP1, and p53, and slightly down-regulate cyclin B1 and cdc2 in ECV304 cells.	Curcumin	0-8	cyclin dependent kinase 1	Homo sapiens	164-168
12139449-1	2002	O(6)-substituted guanines are adenosine 5"-triphosphate (ATP) competitive inhibitors of CDK1/cyclin B1 and CDK2/cyclin A, the O(6) substituent occupying the kinase ribose binding site.	Ribose	164-170	cyclin dependent kinase 1	Homo sapiens	88-92
12222840-0	2002	Suppression of Cdc2 dephosphorylation at the tyrosine 15 residue during nitrosourea-induced G2M phase arrest in glioblastoma cell lines.	Tyrosine	45-53	cyclin dependent kinase 1	Homo sapiens	15-19
12139449-0	2002	Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives.	o(6)	79-83	cyclin dependent kinase 1	Homo sapiens	41-73
12139449-0	2002	Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives.	Guanine	96-103	cyclin dependent kinase 1	Homo sapiens	41-73
12139449-1	2002	O(6)-substituted guanines are adenosine 5"-triphosphate (ATP) competitive inhibitors of CDK1/cyclin B1 and CDK2/cyclin A, the O(6) substituent occupying the kinase ribose binding site.	(6)-substituted	1-16	cyclin dependent kinase 1	Homo sapiens	88-92
12139449-1	2002	O(6)-substituted guanines are adenosine 5"-triphosphate (ATP) competitive inhibitors of CDK1/cyclin B1 and CDK2/cyclin A, the O(6) substituent occupying the kinase ribose binding site.	Guanine	17-25	cyclin dependent kinase 1	Homo sapiens	88-92
12139449-1	2002	O(6)-substituted guanines are adenosine 5"-triphosphate (ATP) competitive inhibitors of CDK1/cyclin B1 and CDK2/cyclin A, the O(6) substituent occupying the kinase ribose binding site.	Adenosine Triphosphate	30-55	cyclin dependent kinase 1	Homo sapiens	88-92
12222840-0	2002	Suppression of Cdc2 dephosphorylation at the tyrosine 15 residue during nitrosourea-induced G2M phase arrest in glioblastoma cell lines.	Nitrosourea Compounds	72-83	cyclin dependent kinase 1	Homo sapiens	15-19
12222840-6	2002	In both cell lines, the amount of Cdc2 protein phosphorylated at the tyrosine 15 residue was increased 2- to 6-fold by treatment with ACNU compared with untreated control cells.	Tyrosine	69-77	cyclin dependent kinase 1	Homo sapiens	34-38
12222840-6	2002	In both cell lines, the amount of Cdc2 protein phosphorylated at the tyrosine 15 residue was increased 2- to 6-fold by treatment with ACNU compared with untreated control cells.	Nimustine	134-138	cyclin dependent kinase 1	Homo sapiens	34-38
12061815-8	2002	SB/PMA treatment also triggered a decline in the S and G(2)M populations, and dephosphorylation of p34(cdc2).	Butyric Acid	0-2	cyclin dependent kinase 1	Homo sapiens	103-107
11983514-4	2002	While screening for inhibitors of cyclin-dependent kinases (CDK"s) and glycogen synthase kinase-3 (GSK-3), we identified pyrazolo[3,4-b]quinoxalines as sub-micromolar inhibitors of CDK1/cyclin B.	flavazole	121-148	cyclin dependent kinase 1	Homo sapiens	181-185
11986303-2	2002	Peroxiredoxin (Prx) I is a member of the peroxiredoxin family of peroxidases and contains a consensus site (Thr(90)-Pro-Lys-Lys) for phosphorylation by cyclin-dependent kinases (CDKs).	Threonine	108-111	cyclin dependent kinase 1	Homo sapiens	178-182
11986303-2	2002	Peroxiredoxin (Prx) I is a member of the peroxiredoxin family of peroxidases and contains a consensus site (Thr(90)-Pro-Lys-Lys) for phosphorylation by cyclin-dependent kinases (CDKs).	Lysine	124-127	cyclin dependent kinase 1	Homo sapiens	178-182
11986303-3	2002	This protein has now been shown to be phosphorylated specifically on Thr(90) by several CDKs, including Cdc2, in vitro.	Threonine	69-72	cyclin dependent kinase 1	Homo sapiens	88-92
11986303-3	2002	This protein has now been shown to be phosphorylated specifically on Thr(90) by several CDKs, including Cdc2, in vitro.	Threonine	69-72	cyclin dependent kinase 1	Homo sapiens	104-108
11986303-9	2002	Phosphorylation of Prx I on Thr(90) both in vitro and in vivo was blocked by roscovitine, an inhibitor of CDKs.	Threonine	28-31	cyclin dependent kinase 1	Homo sapiens	106-110
11986303-9	2002	Phosphorylation of Prx I on Thr(90) both in vitro and in vivo was blocked by roscovitine, an inhibitor of CDKs.	Roscovitine	77-88	cyclin dependent kinase 1	Homo sapiens	106-110
11986303-10	2002	These results suggest that Cdc2-mediated phosphorylation and inactivation of Prx I and the resulting intracellular accumulation of H(2)O(2) might be important for progression of the cell cycle.	Hydrogen Peroxide	131-139	cyclin dependent kinase 1	Homo sapiens	27-31
12061815-8	2002	SB/PMA treatment also triggered a decline in the S and G(2)M populations, and dephosphorylation of p34(cdc2).	Tetradecanoylphorbol Acetate	3-6	cyclin dependent kinase 1	Homo sapiens	103-107
12063555-2	2002	Roscovitine, [2-(R)-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine], is a potent and selective inhibitor of the Cdk2 and Cdc2.	Roscovitine	0-11	cyclin dependent kinase 1	Homo sapiens	136-140
12063555-2	2002	Roscovitine, [2-(R)-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine], is a potent and selective inhibitor of the Cdk2 and Cdc2.	Roscovitine	13-81	cyclin dependent kinase 1	Homo sapiens	136-140
11933169-0	2002	Roles of cAMP in regulation of both MAP kinase and p34(cdc2) kinase activity during meiotic progression, especially beyond the MI stage.	Cyclic AMP	9-13	cyclin dependent kinase 1	Homo sapiens	55-59
12063555-4	2002	Roscovitine was found to inhibit the growth of all 11 HNSCC cell lines in time- and dose-dependent manner and to diminish the Cdk2 and Cdc2 activities.	Roscovitine	0-11	cyclin dependent kinase 1	Homo sapiens	135-139
11933169-5	2002	After 24-hr cultivation in the maturation medium, COCs, which were cultured for an additional 24 hr in the presence of either forskolin or 3-isobutyl-1-methylxanthine (IBMX), exhibited a significant increase in the oocyte cAMP level to the similar level of that in oocytes cultured with PI 3-kinase inhibitor or PKC inhibitor, and the addition of each agent significantly suppressed meiotic progression from the MI to the MII stage and the activity of mitogen-activated protein kinase (MAPK) and p34(cdc2) kinase.	Colforsin	126-135	cyclin dependent kinase 1	Homo sapiens	500-504
11933169-5	2002	After 24-hr cultivation in the maturation medium, COCs, which were cultured for an additional 24 hr in the presence of either forskolin or 3-isobutyl-1-methylxanthine (IBMX), exhibited a significant increase in the oocyte cAMP level to the similar level of that in oocytes cultured with PI 3-kinase inhibitor or PKC inhibitor, and the addition of each agent significantly suppressed meiotic progression from the MI to the MII stage and the activity of mitogen-activated protein kinase (MAPK) and p34(cdc2) kinase.	1-Methyl-3-isobutylxanthine	139-166	cyclin dependent kinase 1	Homo sapiens	500-504
11960485-1	2002	Novel 2-benzylidene-benzofuran-3-ones were designed and synthesized to mimic flavopiridol, a well-established inhibitor of cyclin-dependent kinases (CDKs) which is currently undergoing clinical evaluation.	2-benzylidene-benzofuran-3-ones	6-37	cyclin dependent kinase 1	Homo sapiens	149-153
12049736-0	2002	Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis.	Tyrosine	19-27	cyclin dependent kinase 1	Homo sapiens	38-42
12049736-0	2002	Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis.	Tyrosine	19-27	cyclin dependent kinase 1	Homo sapiens	66-70
12049736-0	2002	Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis.	Paclitaxel	116-121	cyclin dependent kinase 1	Homo sapiens	38-42
12049736-1	2002	ErbB2 overexpression confers resistance to taxol-induced apoptosis by inhibiting p34(Cdc2) activation.	Paclitaxel	43-48	cyclin dependent kinase 1	Homo sapiens	85-89
12049736-3	2002	Here, we report that the inhibitory phosphorylation on Cdc2 tyrosine (Y)15 (Cdc2-Y15-p) is elevated in ErbB2-overexpressing breast cancer cells and primary tumors.	Tyrosine	60-68	cyclin dependent kinase 1	Homo sapiens	55-59
12049736-3	2002	Here, we report that the inhibitory phosphorylation on Cdc2 tyrosine (Y)15 (Cdc2-Y15-p) is elevated in ErbB2-overexpressing breast cancer cells and primary tumors.	Tyrosine	60-68	cyclin dependent kinase 1	Homo sapiens	76-80
12049736-7	2002	Expressing a nonphosphorylatable mutant of Cdc2 renders cells more sensitive to taxol-induced apoptosis.	Paclitaxel	80-85	cyclin dependent kinase 1	Homo sapiens	43-47
12049736-8	2002	Thus, ErbB2 membrane RTK can confer resistance to taxol-induced apoptosis by directly phosphorylating Cdc2.	Paclitaxel	50-55	cyclin dependent kinase 1	Homo sapiens	102-106
11960485-1	2002	Novel 2-benzylidene-benzofuran-3-ones were designed and synthesized to mimic flavopiridol, a well-established inhibitor of cyclin-dependent kinases (CDKs) which is currently undergoing clinical evaluation.	alvocidib	77-89	cyclin dependent kinase 1	Homo sapiens	149-153
11960485-3	2002	Inhibitors of CDKs 1 and 2 that are more potent and selective than flavopiridol were obtained.	alvocidib	67-79	cyclin dependent kinase 1	Homo sapiens	14-26
12054639-1	2002	Flavopiridol has been shown to potently inhibit CDK1 and 2 (cyclin-dependent kinases 1 and 2) and most recently it has been found that it also inhibits CDK9.	alvocidib	0-12	cyclin dependent kinase 1	Homo sapiens	48-58
11925459-6	2002	Gene array analysis suggested that c-Myc, cyclin C, proliferating cell nuclear antigen, cyclin-dependent kinase (cdk)1, cdk2, cdk4, cyclin B and cyclin D2 mRNA levels were lower in selenium-deficient cells than in the cells supplemented with 0.25 micromol/L selenomethionine.	Selenium	181-189	cyclin dependent kinase 1	Homo sapiens	88-118
12054639-1	2002	Flavopiridol has been shown to potently inhibit CDK1 and 2 (cyclin-dependent kinases 1 and 2) and most recently it has been found that it also inhibits CDK9.	alvocidib	0-12	cyclin dependent kinase 1	Homo sapiens	60-92
12054639-4	2002	This structural model indicates that the inhibitor strongly binds to the ATP-binding pocket of CDK9 and the structural comparison of the complex CDK2-flavopiridol correlates the structural differences with differences in inhibition of these CDKs by flavopiridol.	Adenosine Triphosphate	73-76	cyclin dependent kinase 1	Homo sapiens	241-245
12054639-4	2002	This structural model indicates that the inhibitor strongly binds to the ATP-binding pocket of CDK9 and the structural comparison of the complex CDK2-flavopiridol correlates the structural differences with differences in inhibition of these CDKs by flavopiridol.	alvocidib	150-162	cyclin dependent kinase 1	Homo sapiens	241-245
12054639-4	2002	This structural model indicates that the inhibitor strongly binds to the ATP-binding pocket of CDK9 and the structural comparison of the complex CDK2-flavopiridol correlates the structural differences with differences in inhibition of these CDKs by flavopiridol.	alvocidib	249-261	cyclin dependent kinase 1	Homo sapiens	241-245
11958860-7	2002	The CDK-1 inhibitor olomoucine prevented the cytotoxicity of Abeta 31-35 containing peptides in differentiated human teratocarcinoma cell line, Ntera 2/cl-D1 (NT-2) neurons.	olomoucine	20-30	cyclin dependent kinase 1	Homo sapiens	4-9
11958860-7	2002	The CDK-1 inhibitor olomoucine prevented the cytotoxicity of Abeta 31-35 containing peptides in differentiated human teratocarcinoma cell line, Ntera 2/cl-D1 (NT-2) neurons.	Peptides	84-92	cyclin dependent kinase 1	Homo sapiens	4-9
11952644-6	2002	The extent of tyrosine 15-phosphorylated p34CDC2 was assessed in the nuclear fractions.	Tyrosine	14-22	cyclin dependent kinase 1	Homo sapiens	41-48
11896679-10	2002	In summary, Roundup affects cell cycle regulation by delaying activation of the CDK1/cyclin B complex, by synergic effect of glyphosate and formulation products.	glyphosate	125-135	cyclin dependent kinase 1	Homo sapiens	80-84
11896603-1	2002	Cdc25 activates maturation promoting factor (MPF) and promotes mitosis by removing the inhibitory phosphate from the Tyr-15 of Cdc2 in human cells.	Phosphates	98-107	cyclin dependent kinase 1	Homo sapiens	0-4
11896603-1	2002	Cdc25 activates maturation promoting factor (MPF) and promotes mitosis by removing the inhibitory phosphate from the Tyr-15 of Cdc2 in human cells.	Tyrosine	117-120	cyclin dependent kinase 1	Homo sapiens	0-4
12429924-0	2002	Induction of apoptosis in human leukemia cells by the CDK1 inhibitor CGP74514A.	N(2)-(2-aminocyclohexyl)-N(6)-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine	69-78	cyclin dependent kinase 1	Homo sapiens	54-58
12429924-1	2002	We have examined the effects of the CDK1 inhibitor CGP74514A on cell cycle- and apoptosis-related events in human leukemia cells.	N(2)-(2-aminocyclohexyl)-N(6)-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine	51-60	cyclin dependent kinase 1	Homo sapiens	36-40
12429924-8	2002	These findings indicate that the selective CDK1 inhibitor, CGP74514A, induces complex changes in cell cycle-related proteins in human leukemia cells accompanied by extensive mitochondrial damage, caspase activation, and apoptosis.	N(2)-(2-aminocyclohexyl)-N(6)-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine	59-68	cyclin dependent kinase 1	Homo sapiens	43-47
11896679-11	2002	Considering the universality among species of the CDK1/cyclin B regulator, our results question the safety of glyphosate and Roundup on human health.	glyphosate	110-120	cyclin dependent kinase 1	Homo sapiens	50-54
11895447-6	2002	This lack of effect was not due to cytotoxicity, as cells exposed to ergosterol remained viable and, upon supplementing with UCN-01, an activator of Cdk1, they progressed through mitosis.	7-hydroxystaurosporine	125-131	cyclin dependent kinase 1	Homo sapiens	149-153
11895447-0	2002	Differential effects of ergosterol and cholesterol on Cdk1 activation and SRE-driven transcription.	Ergosterol	24-34	cyclin dependent kinase 1	Homo sapiens	54-58
11895447-8	2002	This is interpreted on the basis of the differential action of these sterols, ergosterol contributing to cell membrane formation and cholesterol being required for Cdk1 activation.	Sterols	69-76	cyclin dependent kinase 1	Homo sapiens	164-168
11895447-0	2002	Differential effects of ergosterol and cholesterol on Cdk1 activation and SRE-driven transcription.	Cholesterol	39-50	cyclin dependent kinase 1	Homo sapiens	54-58
11895447-8	2002	This is interpreted on the basis of the differential action of these sterols, ergosterol contributing to cell membrane formation and cholesterol being required for Cdk1 activation.	Cholesterol	133-144	cyclin dependent kinase 1	Homo sapiens	164-168
11741924-4	2002	We demonstrate that in mitosis-arrested cells, ionizing radiation and roscovitine treatment both result in the reversion of BLM phosphorylation, suggesting that BLM could be dephosphorylated through the inhibition of cdc2 kinase.	Roscovitine	70-81	cyclin dependent kinase 1	Homo sapiens	217-221
11888912-7	2002	However, aphidicolin-synchronized HN12 cells released in the presence of perifosine (10 microM) demonstrated increased expression of total p21(WAF1) and increased association of p21(WAF1) with cyclin-cdk complexes resulting in reduced cdc2 activity.	Aphidicolin	9-20	cyclin dependent kinase 1	Homo sapiens	235-239
11888912-7	2002	However, aphidicolin-synchronized HN12 cells released in the presence of perifosine (10 microM) demonstrated increased expression of total p21(WAF1) and increased association of p21(WAF1) with cyclin-cdk complexes resulting in reduced cdc2 activity.	perifosine	73-83	cyclin dependent kinase 1	Homo sapiens	235-239
11841447-7	2002	We found that the expression of the cell cycle checkpoint protein Chk1 was reduced in the etoposide-treated p53-transfected cells by 24 h, and this correlated with a reduction in the extent of etoposide-induced phosphorylation of CDK1 at tyrosine 15 (Y15).	Etoposide	90-99	cyclin dependent kinase 1	Homo sapiens	230-234
11839095-1	2002	The WEE1 protein kinase carries out the inhibitory phosphorylation of CDC2 on tyrosine 15 (Tyr15), which is required for activation of the G(2)-phase checkpoint in response to DNA damage.	Tyrosine	78-86	cyclin dependent kinase 1	Homo sapiens	70-74
11839095-12	2002	Thus inhibition of PD0166285-induced G(2)-phase checkpoint abrogation by TP53 was achieved at least in part through partial blockage of CDC2 dephosphorylation of Tyr15 and inhibition of cyclin B1 expression.	PD 0166285	19-28	cyclin dependent kinase 1	Homo sapiens	136-140
11843726-4	2002	The activity of paclitaxel was correlated with an elevation of cyclin B1/CDC2 activity, prolonged mitotic arrest, and Bcl-2 phosphorylation.	Paclitaxel	16-26	cyclin dependent kinase 1	Homo sapiens	73-77
11841447-7	2002	We found that the expression of the cell cycle checkpoint protein Chk1 was reduced in the etoposide-treated p53-transfected cells by 24 h, and this correlated with a reduction in the extent of etoposide-induced phosphorylation of CDK1 at tyrosine 15 (Y15).	Etoposide	193-202	cyclin dependent kinase 1	Homo sapiens	230-234
11841447-7	2002	We found that the expression of the cell cycle checkpoint protein Chk1 was reduced in the etoposide-treated p53-transfected cells by 24 h, and this correlated with a reduction in the extent of etoposide-induced phosphorylation of CDK1 at tyrosine 15 (Y15).	Tyrosine	238-246	cyclin dependent kinase 1	Homo sapiens	230-234
11807090-10	2002	Specifically, the Chfr pathway prolongs the phosphorylated state of tyrosine 15 in Cdc2.	Tyrosine	68-76	cyclin dependent kinase 1	Homo sapiens	83-87
11861764-8	2002	In synchronized cultures, cytosolic survivin abruptly increased at mitosis, physically associated with p34(cdc2), and was phosphorylated by p34(cdc2) on Thr(34), in vivo.	Threonine	153-156	cyclin dependent kinase 1	Homo sapiens	144-148
11878934-3	2002	Poly(A) polymerase (PAP), the enzyme responsible for poly(A) addition to primary transcripts, contains multiple consensus phosphorylation sites for p34(cdc2) cyclin B kinase that regulates its catalytic activity.	Poly A	53-60	cyclin dependent kinase 1	Homo sapiens	152-156
11782377-7	2002	Synergistic potentiation of STI571-mediated lethality by PD184352 was associated with multiple perturbations in signaling and apoptotic regulatory pathways, including caspase-dependent down-regulation of Bcr-Abl and Bcl-2; caspase-independent down-regulation of Bcl-x(L) and Mcl-1; activation of JNK, p38 MAPK, and p34(cdc2); and diminished phosphorylation of Stat5 and CREB.	Imatinib Mesylate	28-34	cyclin dependent kinase 1	Homo sapiens	319-323
11687586-10	2002	Mutation of RGC-32 protein at Thr-91 prevented the p34CDC2-mediated phosphorylation and resulted in loss of p34CDC2 kinase enhancing activity.	Threonine	30-33	cyclin dependent kinase 1	Homo sapiens	51-58
11782384-0	2002	Abolishment of the Tyr-15 inhibitory phosphorylation site on cdc2 reduces the radiation-induced G(2) delay, revealing a potential checkpoint in early mitosis.	Tyrosine	19-22	cyclin dependent kinase 1	Homo sapiens	61-65
11782384-1	2002	cdc2 is inactivated before mitosis by phosphorylation at its inhibitory sites, Thr-14 and Tyr-15.	Threonine	79-82	cyclin dependent kinase 1	Homo sapiens	0-4
11782377-7	2002	Synergistic potentiation of STI571-mediated lethality by PD184352 was associated with multiple perturbations in signaling and apoptotic regulatory pathways, including caspase-dependent down-regulation of Bcr-Abl and Bcl-2; caspase-independent down-regulation of Bcl-x(L) and Mcl-1; activation of JNK, p38 MAPK, and p34(cdc2); and diminished phosphorylation of Stat5 and CREB.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	57-65	cyclin dependent kinase 1	Homo sapiens	319-323
11782384-1	2002	cdc2 is inactivated before mitosis by phosphorylation at its inhibitory sites, Thr-14 and Tyr-15.	Tyrosine	90-93	cyclin dependent kinase 1	Homo sapiens	0-4
11782384-4	2002	We have shown that the radiation-induced G(2) delay is preserved in wild-type or cdc2-AY-transfected cells (which retain Tyr-15); this delay is abolished in cdc2-TF- or cdc2-AF-transfected cells (which lack Tyr-15).	Tyrosine	121-124	cyclin dependent kinase 1	Homo sapiens	81-85
11782384-4	2002	We have shown that the radiation-induced G(2) delay is preserved in wild-type or cdc2-AY-transfected cells (which retain Tyr-15); this delay is abolished in cdc2-TF- or cdc2-AF-transfected cells (which lack Tyr-15).	Tyrosine	207-210	cyclin dependent kinase 1	Homo sapiens	157-161
11726805-3	2001	The Abeta 1-42, 1-40 and 25-35 peptides were shown to be substrates for the cdc2 kinase and phosphorylated on the Serine 26 residue.	Peptides	31-39	cyclin dependent kinase 1	Homo sapiens	76-80
11782384-4	2002	We have shown that the radiation-induced G(2) delay is preserved in wild-type or cdc2-AY-transfected cells (which retain Tyr-15); this delay is abolished in cdc2-TF- or cdc2-AF-transfected cells (which lack Tyr-15).	Tyrosine	207-210	cyclin dependent kinase 1	Homo sapiens	157-161
11750022-5	2002	All [(dien)Cu(B)NO(3))](NO(3)) complexes had an activity against colon cancer cells (HT-29), inducing G2/M cell cycle arrest, an effect that for most of the complexes could be attributed to p34cdc2 inhibition by tyrosine-phosphorylation and/or to induction of (cyclin-dependent kinase inhibitor) p21(WAF1).	Copper	11-13	cyclin dependent kinase 1	Homo sapiens	190-197
11724933-10	2001	Fluorescence-activated cell sorting measurements and Western blot analysis show DIOA caused a significant reduction of the cell fraction in proliferative phase and a change in phosphorylation of retinoblastoma protein (Rb) and cdc2, suggesting that KCC3 activity is important for cell cycle progression.	Dioa	80-84	cyclin dependent kinase 1	Homo sapiens	227-231
11756316-7	2002	In vitro, p34 cell division cycle (p34(cdc2)) kinase-directed incorporation of [gamma-(32)P]ATP was reduced in a mutant peptide compared with native peptide (387P: 100% vs. 387L: 28.4 +/- 5.8%; P = 0.0012).	[gamma-(32)p]atp	79-95	cyclin dependent kinase 1	Homo sapiens	39-43
12658801-8	2002	Upon irradiation, p34cdc2 in U937-pZeosv2(+) was maintained in an inactive state by phosphorylation on threonine 14 (Thr 14) and tyrosine 15 (Tyr 15), which was associated with a dramatic decrease of nuclear CDC25A, CDC25B and CDC25C proteins.	Threonine	103-112	cyclin dependent kinase 1	Homo sapiens	18-25
12658801-8	2002	Upon irradiation, p34cdc2 in U937-pZeosv2(+) was maintained in an inactive state by phosphorylation on threonine 14 (Thr 14) and tyrosine 15 (Tyr 15), which was associated with a dramatic decrease of nuclear CDC25A, CDC25B and CDC25C proteins.	Threonine	117-120	cyclin dependent kinase 1	Homo sapiens	18-25
12658801-8	2002	Upon irradiation, p34cdc2 in U937-pZeosv2(+) was maintained in an inactive state by phosphorylation on threonine 14 (Thr 14) and tyrosine 15 (Tyr 15), which was associated with a dramatic decrease of nuclear CDC25A, CDC25B and CDC25C proteins.	Tyrosine	129-137	cyclin dependent kinase 1	Homo sapiens	18-25
12658801-8	2002	Upon irradiation, p34cdc2 in U937-pZeosv2(+) was maintained in an inactive state by phosphorylation on threonine 14 (Thr 14) and tyrosine 15 (Tyr 15), which was associated with a dramatic decrease of nuclear CDC25A, CDC25B and CDC25C proteins.	Tyrosine	142-145	cyclin dependent kinase 1	Homo sapiens	18-25
12658801-9	2002	In contrast, p34cdc2 in U937-ASPI3K maintained in an active state by dephosphorylation on threonine 14 (Thr 14) and tyrosine 15 (Tyr 15), which was associated with constant nuclear CDC25A, CDC25B and CDC25C protein abundance before and after irradiation.	Threonine	90-99	cyclin dependent kinase 1	Homo sapiens	13-20
12658801-9	2002	In contrast, p34cdc2 in U937-ASPI3K maintained in an active state by dephosphorylation on threonine 14 (Thr 14) and tyrosine 15 (Tyr 15), which was associated with constant nuclear CDC25A, CDC25B and CDC25C protein abundance before and after irradiation.	Threonine	104-107	cyclin dependent kinase 1	Homo sapiens	13-20
12658801-9	2002	In contrast, p34cdc2 in U937-ASPI3K maintained in an active state by dephosphorylation on threonine 14 (Thr 14) and tyrosine 15 (Tyr 15), which was associated with constant nuclear CDC25A, CDC25B and CDC25C protein abundance before and after irradiation.	Tyrosine	116-124	cyclin dependent kinase 1	Homo sapiens	13-20
12658801-9	2002	In contrast, p34cdc2 in U937-ASPI3K maintained in an active state by dephosphorylation on threonine 14 (Thr 14) and tyrosine 15 (Tyr 15), which was associated with constant nuclear CDC25A, CDC25B and CDC25C protein abundance before and after irradiation.	Tyrosine	129-132	cyclin dependent kinase 1	Homo sapiens	13-20
11719452-6	2001	At the cellular level, 0.5 microM PD0166285 dramatically inhibits irradiation-induced Cdc2 phosphorylation at the Tyr-15 and Thr-14 in seven of seven cancer cell lines tested.	PD 0166285	34-43	cyclin dependent kinase 1	Homo sapiens	86-90
11726805-5	2001	In NT-2 neurons the levels of pSAbeta were increased in the presence of exogenous Abeta and this increase was prevented by a cdc2 protein kinase inhibitor, olomoucine, that also prevented Abeta cytotoxicity.	olomoucine	156-166	cyclin dependent kinase 1	Homo sapiens	125-129
11723230-6	2001	Cdc2 activity was much higher in KAR-2 than in vinblastine-treated cells, indicating a stronger mitotic arrest.	Vinblastine	47-58	cyclin dependent kinase 1	Homo sapiens	0-4
11719058-3	2001	A switch-like mechanism integrates signals of cellular status and commits the cell to mitosis by abruptly removing inhibitory phosphate from preformed cyclin:Cdk1 complexes.	Phosphates	126-135	cyclin dependent kinase 1	Homo sapiens	158-162
11751453-1	2001	The mitotic inducer Cdc2 is negatively regulated, in part, by phosphorylation on tyrosine 15.	Tyrosine	81-89	cyclin dependent kinase 1	Homo sapiens	20-24
11751453-2	2001	Human Wee1 is a tyrosine-specific protein kinase that phosphorylates Cdc2 on tyrosine 15.	Tyrosine	16-24	cyclin dependent kinase 1	Homo sapiens	69-73
11719462-7	2001	In an attempt to define the signal transduction mechanisms responsible for MMR-mediated G(2) arrest, we examined the levels of tyrosine 15 phosphorylation of cdc2 (phospho-Tyr15-cdc2), a key regulator of the G(2)-M transition.	Tyrosine	127-135	cyclin dependent kinase 1	Homo sapiens	158-162
11719462-7	2001	In an attempt to define the signal transduction mechanisms responsible for MMR-mediated G(2) arrest, we examined the levels of tyrosine 15 phosphorylation of cdc2 (phospho-Tyr15-cdc2), a key regulator of the G(2)-M transition.	Tyrosine	127-135	cyclin dependent kinase 1	Homo sapiens	178-182
11719452-6	2001	At the cellular level, 0.5 microM PD0166285 dramatically inhibits irradiation-induced Cdc2 phosphorylation at the Tyr-15 and Thr-14 in seven of seven cancer cell lines tested.	Tyrosine	114-117	cyclin dependent kinase 1	Homo sapiens	86-90
11598051-10	2001	Whereas cyclin B1 was not detectably affected in E22-exposed cells, Cdk1 was maintained in a tyrosine-phosphorylated inactive state and lost its affinity for p13(suc1)-agarose beads.	Tyrosine	93-101	cyclin dependent kinase 1	Homo sapiens	68-72
11533036-6	2001	NHERF-1 possesses two serines (Ser(279) and Ser(301)) that conform to the SPX(K/R) motif preferred for phosphorylation by Cdc2.	Serine	22-29	cyclin dependent kinase 1	Homo sapiens	122-126
11533036-6	2001	NHERF-1 possesses two serines (Ser(279) and Ser(301)) that conform to the SPX(K/R) motif preferred for phosphorylation by Cdc2.	Serine	31-34	cyclin dependent kinase 1	Homo sapiens	122-126
11533036-6	2001	NHERF-1 possesses two serines (Ser(279) and Ser(301)) that conform to the SPX(K/R) motif preferred for phosphorylation by Cdc2.	Serine	44-47	cyclin dependent kinase 1	Homo sapiens	122-126
11533036-7	2001	Mutation of either of these serines reduced Cdc2-mediated phosphorylation of NHERF-1 in vitro, and mutation of both residues together completely abolished Cdc2-mediated phosphorylation.	Serine	28-35	cyclin dependent kinase 1	Homo sapiens	44-48
11533036-13	2001	These data reveal that cellular NHERF-1 is phosphorylated during mitosis phase by Cdc2 at Ser(279) and Ser(301) and that this phosphorylation regulates NHERF-1 oligomerization and association with Pin1.	Serine	90-93	cyclin dependent kinase 1	Homo sapiens	82-86
11598051-10	2001	Whereas cyclin B1 was not detectably affected in E22-exposed cells, Cdk1 was maintained in a tyrosine-phosphorylated inactive state and lost its affinity for p13(suc1)-agarose beads.	Sepharose	168-175	cyclin dependent kinase 1	Homo sapiens	68-72
11774038-6	2001	Both these serines are within sequence contexts suitable for proline-directed kinases such as Cdc2.	Serine	11-18	cyclin dependent kinase 1	Homo sapiens	94-98
11704824-4	2001	Furthermore, this activation correlated with the biochemical regulation of the maturation-promoting factor (MPF, cdc2/cyclin B), as both DRB and antisense depletion of CK2, as well as SB203580 were associated with an inhibition of its activation in response to nocodazole.	Nocodazole	261-271	cyclin dependent kinase 1	Homo sapiens	113-117
11483735-6	2001	(iii) The processing of ICP0 forms E and F was blocked in HEL fibroblasts infected with R325 or with wild-type virus and treated with roscovitine, a specific inhibitor of cell cycle-dependent kinases cdc2, cdk2, and cdk5.	Roscovitine	134-145	cyclin dependent kinase 1	Homo sapiens	200-204
11562764-8	2001	We also found that quercetin markedly increased Cdk-inhibitor p21CIP1/WAF1 protein level after treatment for 48 h or longer, and the induction of p21CIP1/WAF1 increased its association with Cdc2-cyclin B1 complex, however, up-regulation of p53 by quercetin was not observed.	Quercetin	19-28	cyclin dependent kinase 1	Homo sapiens	190-194
11562764-8	2001	We also found that quercetin markedly increased Cdk-inhibitor p21CIP1/WAF1 protein level after treatment for 48 h or longer, and the induction of p21CIP1/WAF1 increased its association with Cdc2-cyclin B1 complex, however, up-regulation of p53 by quercetin was not observed.	Quercetin	247-256	cyclin dependent kinase 1	Homo sapiens	190-194
11553333-6	2001	We show that the cyclin-dependent kinase, cdc2, phosphorylates 4E-BP1 at Thr-70 and that phosphorylation of this site is permissive for Ser-65 phosphorylation.	Threonine	73-76	cyclin dependent kinase 1	Homo sapiens	42-46
11553333-6	2001	We show that the cyclin-dependent kinase, cdc2, phosphorylates 4E-BP1 at Thr-70 and that phosphorylation of this site is permissive for Ser-65 phosphorylation.	Serine	136-139	cyclin dependent kinase 1	Homo sapiens	42-46
11591813-2	2001	The cyclin B-p34(cdc2) kinase (CDK1) has been shown to phosphorylate RIIalpha on T54 and this has been proposed to alter the subcellular localization of RIIalpha.	riialpha	69-77	cyclin dependent kinase 1	Homo sapiens	31-35
11591813-2	2001	The cyclin B-p34(cdc2) kinase (CDK1) has been shown to phosphorylate RIIalpha on T54 and this has been proposed to alter the subcellular localization of RIIalpha.	riialpha	153-161	cyclin dependent kinase 1	Homo sapiens	31-35
11591814-1	2001	CDK1 phosphorylates the A-kinase regulatory subunit RIIalpha on threonine 54 (T54) at mitosis, an event proposed to alter the subcellular localization of RIIalpha.	Threonine	64-73	cyclin dependent kinase 1	Homo sapiens	0-4
11591814-1	2001	CDK1 phosphorylates the A-kinase regulatory subunit RIIalpha on threonine 54 (T54) at mitosis, an event proposed to alter the subcellular localization of RIIalpha.	riialpha	52-60	cyclin dependent kinase 1	Homo sapiens	0-4
11591814-9	2001	Our results suggest that CDK1-mediated T54 phosphorylation of RIIalpha constitutes a molecular switch controlling anchoring of RIIalpha to chromatin-bound AKAP95, where the PKA-AKAP95 complex participates in remodeling chromatin during mitosis.	riialpha	62-70	cyclin dependent kinase 1	Homo sapiens	25-29
11591814-9	2001	Our results suggest that CDK1-mediated T54 phosphorylation of RIIalpha constitutes a molecular switch controlling anchoring of RIIalpha to chromatin-bound AKAP95, where the PKA-AKAP95 complex participates in remodeling chromatin during mitosis.	riialpha	127-135	cyclin dependent kinase 1	Homo sapiens	25-29
11483735-13	2001	(v) Last, cdc2 was active in infected cells, and this activity was inhibited by roscovitine.	Roscovitine	80-91	cyclin dependent kinase 1	Homo sapiens	10-14
11500387-4	2001	Under prolonged expression of the c-fos gene, however, the amount of wee1 kinase was increased and its target cdc2 molecule was constitutively phosphorylated on its tyrosine residue, where Th1 cells went into aberrant mitosis.	Tyrosine	165-173	cyclin dependent kinase 1	Homo sapiens	110-114
11488607-8	2001	Vanadate also increased p21 and Chk1 levels and reduced Cdc25C expression, leading to phosphorylation of Cdc2 and a slight increase in cyclin B1 expression as analyzed by Western blot.	Vanadates	0-8	cyclin dependent kinase 1	Homo sapiens	56-60
11466212-4	2001	In the denuded oocytes, U0126 suppressed MAP kinase activity, p34(cdc2) kinase activity, and meiotic progression to the MII stage; however, LY294002 did not significantly affect the activity of these kinases and meiotic progression.	U 0126	24-29	cyclin dependent kinase 1	Homo sapiens	66-70
11479224-6	2001	U87MG glioma cells treated with TMZ underwent G(2)-M arrest associated with Chk1 activation and phosphorylation of both cdc25C and cdc2.	Temozolomide	32-35	cyclin dependent kinase 1	Homo sapiens	120-124
11451350-7	2001	CDK1 and CDK2, and cyclin A and cyclin B1 messenger RNAs were decreased 6 days after castration, increased 6-12 hours after TP treatment, and were expressed at high levels in recurrent CWR22 tumors.	Testosterone Propionate	124-126	cyclin dependent kinase 1	Homo sapiens	0-4
11464216-1	2001	Flavopiridol (FP), an inhibitor of cyclin dependent kinases 1, 2 and 4, potently induced apoptosis in U937 human monoblastic leukemia cells.	alvocidib	0-12	cyclin dependent kinase 1	Homo sapiens	35-70
11464216-1	2001	Flavopiridol (FP), an inhibitor of cyclin dependent kinases 1, 2 and 4, potently induced apoptosis in U937 human monoblastic leukemia cells.	alvocidib	14-16	cyclin dependent kinase 1	Homo sapiens	35-70
11431348-6	2001	The ability of UCN-01, when combined with PD184352, to antagonize cdc25C/14-3-3 protein binding, promote dephosphorylation of p34(cdc2), and potentiate apoptosis was mimicked by the ataxia telangectasia mutation inhibitor caffeine.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	42-50	cyclin dependent kinase 1	Homo sapiens	66-70
11384110-6	2001	ATRA also inhibited docetaxel-induced activation of MAPK indicating that the effects of docetaxel and ATRA on cdc2 phosphorylation are dependent on MAPK.	Tretinoin	102-106	cyclin dependent kinase 1	Homo sapiens	110-114
11479920-6	2001	We also found an accumulation of phosphorylated cdc2 after 2-ME treatment.	2-Methoxyestradiol	59-63	cyclin dependent kinase 1	Homo sapiens	48-52
11439342-6	2001	However indirubin-3"-monoxime inhibits the phosphorylation of consensus CDK phosphorylation sites as well as of nucleolin at a specific CDK1/cyclin B phosphorylation site, suggesting a direct action on the mitotic CDK1/cyclin B.	indirubin-3'-monoxime	8-29	cyclin dependent kinase 1	Homo sapiens	136-140
11439342-6	2001	However indirubin-3"-monoxime inhibits the phosphorylation of consensus CDK phosphorylation sites as well as of nucleolin at a specific CDK1/cyclin B phosphorylation site, suggesting a direct action on the mitotic CDK1/cyclin B.	indirubin-3'-monoxime	8-29	cyclin dependent kinase 1	Homo sapiens	214-218
11384110-4	2001	Docetaxel caused phosphorylation and hence inactivation of cdc2 kinase result ing in G2/M arrest.	Docetaxel	0-9	cyclin dependent kinase 1	Homo sapiens	59-63
11384110-5	2001	ATRA inhibited docetaxel-induced phosphorylation of cdc2 resulting in activation of cdc2 kinase and partial reversal of the G2/M arrest.	Tretinoin	0-4	cyclin dependent kinase 1	Homo sapiens	52-56
11384110-5	2001	ATRA inhibited docetaxel-induced phosphorylation of cdc2 resulting in activation of cdc2 kinase and partial reversal of the G2/M arrest.	Tretinoin	0-4	cyclin dependent kinase 1	Homo sapiens	84-88
11384110-7	2001	We conclude that ATRA synergistically enhances docetaxel toxicity by down-regulating Bcl-2 expression and partially reverses the docetaxel-induced G2/M arrest by inhibiting docetaxel-induced cdc2 phosphorylation in a pathway that is dependent on MAPK.	Tretinoin	17-21	cyclin dependent kinase 1	Homo sapiens	191-195
11278490-2	2001	In mammalian cells, the G(2) checkpoint prevents the Cdc25C phosphatase from removing inhibitory phosphate groups from the mitosis-promoting kinase Cdc2.	Phosphates	97-106	cyclin dependent kinase 1	Homo sapiens	53-57
11384110-5	2001	ATRA inhibited docetaxel-induced phosphorylation of cdc2 resulting in activation of cdc2 kinase and partial reversal of the G2/M arrest.	Docetaxel	15-24	cyclin dependent kinase 1	Homo sapiens	52-56
11384110-5	2001	ATRA inhibited docetaxel-induced phosphorylation of cdc2 resulting in activation of cdc2 kinase and partial reversal of the G2/M arrest.	Docetaxel	15-24	cyclin dependent kinase 1	Homo sapiens	84-88
11384110-6	2001	ATRA also inhibited docetaxel-induced activation of MAPK indicating that the effects of docetaxel and ATRA on cdc2 phosphorylation are dependent on MAPK.	Tretinoin	0-4	cyclin dependent kinase 1	Homo sapiens	110-114
11384110-6	2001	ATRA also inhibited docetaxel-induced activation of MAPK indicating that the effects of docetaxel and ATRA on cdc2 phosphorylation are dependent on MAPK.	Docetaxel	20-29	cyclin dependent kinase 1	Homo sapiens	110-114
11384110-6	2001	ATRA also inhibited docetaxel-induced activation of MAPK indicating that the effects of docetaxel and ATRA on cdc2 phosphorylation are dependent on MAPK.	Docetaxel	88-97	cyclin dependent kinase 1	Homo sapiens	110-114
11278490-8	2001	Caffeine or UCN-01 abolishes the extreme radioresistance with the strong G(2) arrest and at the same time reduces the phosphorylation of Cdc2 in A1-5 cells.	Caffeine	0-8	cyclin dependent kinase 1	Homo sapiens	137-141
11278490-8	2001	Caffeine or UCN-01 abolishes the extreme radioresistance with the strong G(2) arrest and at the same time reduces the phosphorylation of Cdc2 in A1-5 cells.	7-hydroxystaurosporine	12-18	cyclin dependent kinase 1	Homo sapiens	137-141
11394741-2	2001	By exploiting available structural information, we designed an ATP-site directed ligand scaffold that allowed us to identify 4-(3-methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-ylamino)-benzenesulfonamide as a new potent inhibitor of CDK1 in a subsequent database search.	Adenosine Triphosphate	63-66	cyclin dependent kinase 1	Homo sapiens	229-233
11322924-0	2001	Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1.	Flavonoids	32-42	cyclin dependent kinase 1	Homo sapiens	142-146
11394741-2	2001	By exploiting available structural information, we designed an ATP-site directed ligand scaffold that allowed us to identify 4-(3-methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-ylamino)-benzenesulfonamide as a new potent inhibitor of CDK1 in a subsequent database search.	4-(3-methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-ylamino)-benzenesulfonamide	125-199	cyclin dependent kinase 1	Homo sapiens	229-233
11286989-4	2001	Genistein treatment (45 microM) increased the phosphorylation of Cdc2 by 3-fold, decreased the activity of Cdc2 by 70% after 8 hr, and by 24 hr reduced the expression of Cdc2 by 70%.	Genistein	0-9	cyclin dependent kinase 1	Homo sapiens	65-69
11286989-4	2001	Genistein treatment (45 microM) increased the phosphorylation of Cdc2 by 3-fold, decreased the activity of Cdc2 by 70% after 8 hr, and by 24 hr reduced the expression of Cdc2 by 70%.	Genistein	0-9	cyclin dependent kinase 1	Homo sapiens	107-111
11286989-4	2001	Genistein treatment (45 microM) increased the phosphorylation of Cdc2 by 3-fold, decreased the activity of Cdc2 by 70% after 8 hr, and by 24 hr reduced the expression of Cdc2 by 70%.	Genistein	0-9	cyclin dependent kinase 1	Homo sapiens	107-111
11286989-5	2001	In addition, genistein enhanced the expression of the cell cycle inhibitor p21(waf/cip1) by 10- to 15-fold, increased p21(waf/cip1) association with Cdc2 by 2-fold, and increased the expression of the tumor suppressor p53 by 2.8-fold.	Genistein	13-22	cyclin dependent kinase 1	Homo sapiens	149-153
11286989-8	2001	From these results, we conclude that genistein inhibits the growth of nonneoplastic MCF-10F human breast cells by preventing the G2/M phase transition, induces the expression of the cell cycle inhibitor p21(waf/cip1) as well as its interaction with Cdc2, and inhibits the activity of Cdc2 in a phosphorylation-related manner.	Genistein	37-46	cyclin dependent kinase 1	Homo sapiens	249-253
11286989-8	2001	From these results, we conclude that genistein inhibits the growth of nonneoplastic MCF-10F human breast cells by preventing the G2/M phase transition, induces the expression of the cell cycle inhibitor p21(waf/cip1) as well as its interaction with Cdc2, and inhibits the activity of Cdc2 in a phosphorylation-related manner.	Genistein	37-46	cyclin dependent kinase 1	Homo sapiens	284-288
11325241-0	2001	Microxine, a new cdc2 kinase inhibitor from the Australian marine sponge Microxina species.	microxine	0-9	cyclin dependent kinase 1	Homo sapiens	17-21
11325241-3	2001	Microxine was found to weakly inhibit cdc2 kinase activity with an IC(50) of 13 microM.	microxine	0-9	cyclin dependent kinase 1	Homo sapiens	38-42
11306507-8	2001	Moreover, induction of tyrosine phosphorylation of CDC2 and reduction of CDC2 kinase activity after irradiation was less significant in TE8-CDC25B than in TE8-neo.	Tyrosine	23-31	cyclin dependent kinase 1	Homo sapiens	51-55
11266545-6	2001	Addition of CDK1/cyclin B decreased the elongation rate for valine whereas the rate for serine and phenylalanine elongation was increased.	Valine	60-66	cyclin dependent kinase 1	Homo sapiens	12-16
11283255-8	2001	Several observations suggested that the latter cells were in G2 phase, prior to the onset of mitosis: these cells contained uncondensed chromosomes, low levels of cyclin B-associated kinase activity, and high levels of tyrosine-phosphorylated Cdk1.	Tyrosine	219-227	cyclin dependent kinase 1	Homo sapiens	243-247
11266545-6	2001	Addition of CDK1/cyclin B decreased the elongation rate for valine whereas the rate for serine and phenylalanine elongation was increased.	Serine	88-94	cyclin dependent kinase 1	Homo sapiens	12-16
11098059-6	2001	Coinciding with the decrease in cyclin B1-Cdc2 activity, there is an increase in tyrosine phosphorylation of Cdc2, suggesting that an increase in the inactive Tyr-15-phosphorylated form of Cdc2 is involved in the decrease in cyclin B1-Cdc2 activity and G(2) arrest.	Tyrosine	81-89	cyclin dependent kinase 1	Homo sapiens	109-113
11098059-6	2001	Coinciding with the decrease in cyclin B1-Cdc2 activity, there is an increase in tyrosine phosphorylation of Cdc2, suggesting that an increase in the inactive Tyr-15-phosphorylated form of Cdc2 is involved in the decrease in cyclin B1-Cdc2 activity and G(2) arrest.	Tyrosine	81-89	cyclin dependent kinase 1	Homo sapiens	109-113
11098059-6	2001	Coinciding with the decrease in cyclin B1-Cdc2 activity, there is an increase in tyrosine phosphorylation of Cdc2, suggesting that an increase in the inactive Tyr-15-phosphorylated form of Cdc2 is involved in the decrease in cyclin B1-Cdc2 activity and G(2) arrest.	Tyrosine	81-89	cyclin dependent kinase 1	Homo sapiens	109-113
11098059-6	2001	Coinciding with the decrease in cyclin B1-Cdc2 activity, there is an increase in tyrosine phosphorylation of Cdc2, suggesting that an increase in the inactive Tyr-15-phosphorylated form of Cdc2 is involved in the decrease in cyclin B1-Cdc2 activity and G(2) arrest.	Tyrosine	159-162	cyclin dependent kinase 1	Homo sapiens	109-113
11098059-6	2001	Coinciding with the decrease in cyclin B1-Cdc2 activity, there is an increase in tyrosine phosphorylation of Cdc2, suggesting that an increase in the inactive Tyr-15-phosphorylated form of Cdc2 is involved in the decrease in cyclin B1-Cdc2 activity and G(2) arrest.	Tyrosine	159-162	cyclin dependent kinase 1	Homo sapiens	109-113
11098059-6	2001	Coinciding with the decrease in cyclin B1-Cdc2 activity, there is an increase in tyrosine phosphorylation of Cdc2, suggesting that an increase in the inactive Tyr-15-phosphorylated form of Cdc2 is involved in the decrease in cyclin B1-Cdc2 activity and G(2) arrest.	Tyrosine	159-162	cyclin dependent kinase 1	Homo sapiens	109-113
11096075-6	2001	Furthermore, a dominant-negative p53 protein, impairing doxorubicin-induced G2 arrest, prevents transcriptional down-regulation of the mitotic cyclins, cdk1, and cdc25C genes.	Doxorubicin	56-67	cyclin dependent kinase 1	Homo sapiens	152-156
11396178-4	2001	Investigation of cyclin-dependent kinases, Cdk2 and Cdc2, showed activity of Cdc2, but not Cdk2, increased markedly in response to curcumin.	Curcumin	131-139	cyclin dependent kinase 1	Homo sapiens	52-56
11396178-4	2001	Investigation of cyclin-dependent kinases, Cdk2 and Cdc2, showed activity of Cdc2, but not Cdk2, increased markedly in response to curcumin.	Curcumin	131-139	cyclin dependent kinase 1	Homo sapiens	77-81
11013232-6	2001	Testing of a series of indoles and bis-indoles against GSK-3 beta, CDK1/cyclin B, and CDK5/p25 shows that only indirubins inhibit these kinases.	Indoles	23-30	cyclin dependent kinase 1	Homo sapiens	67-71
11237594-7	2001	Addition of olomoucine, a specific inhibitor of CDK2 and CDC2 activity on the other hand reduces the expression of the reporter.	olomoucine	12-22	cyclin dependent kinase 1	Homo sapiens	57-61
11313973-7	2001	Furthermore, staurosporine, an inhibitor for a broad range of serine/threonine kinases including cdc2, was found to enhance hyperploid formation in U251MG cells by accelerating the induction of mitotic slippage.	Staurosporine	13-26	cyclin dependent kinase 1	Homo sapiens	97-101
11136719-6	2001	When phosphorylated by purified cdc2-cyclin B, however, it gains the ability to introduce positive supercoils into DNA in the presence of ATP and topoisomerase I.	Adenosine Triphosphate	138-141	cyclin dependent kinase 1	Homo sapiens	32-36
11163155-2	2001	In some eukaryotic cells, mitotic entry relies heavily on regulation of the state of tyrosine phosphorylation of the cyclin-dependent kinase Cdc2.	Tyrosine	85-93	cyclin dependent kinase 1	Homo sapiens	141-145
11163155-3	2001	Evidence that checkpoint regulation of cell-cycle progression operates through controlling the state of Cdc2 tyrosine phosphorylation exists.	Tyrosine	109-117	cyclin dependent kinase 1	Homo sapiens	104-108
11013232-6	2001	Testing of a series of indoles and bis-indoles against GSK-3 beta, CDK1/cyclin B, and CDK5/p25 shows that only indirubins inhibit these kinases.	bis-indoles	35-46	cyclin dependent kinase 1	Homo sapiens	67-71
11013232-7	2001	The structure-activity relationship study also suggests that indirubins bind to GSK-3 beta"s ATP binding pocket in a way similar to their binding to CDKs, the details of which were recently revealed by crystallographic analysis.	indirubin	61-71	cyclin dependent kinase 1	Homo sapiens	149-153
11120603-6	2001	In both cell lines, caffeine-induced activation of CDC2 kinase was detected only in cells arrested at G2 and CDC2 kinase-activated cells died exhibiting features of apoptosis.	Caffeine	20-28	cyclin dependent kinase 1	Homo sapiens	51-55
11180394-6	2001	G2M phase cell accumulations induced in MCF7 cells by L-Ann or Dx were accompanied by a decrease in cdc2 kinase activity and in cyclin B1 and cdc2 expression.	l-ann	54-59	cyclin dependent kinase 1	Homo sapiens	100-104
11272285-0	2001	Inhibition of mitotic cyclin B and cdc2 kinase activity by selenomethionine in synchronized colon cancer cells.	Selenomethionine	59-75	cyclin dependent kinase 1	Homo sapiens	35-39
11161389-0	2001	Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells.	indirubin	50-59	cyclin dependent kinase 1	Homo sapiens	14-39
11161389-0	2001	Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells.	indirubin	50-59	cyclin dependent kinase 1	Homo sapiens	41-45
11161389-9	2001	Treatment of MCF-7 cells with growth inhibitory concentrations of indirubin-3"-monoxime induces dose-dependent inhibition of the CDK1 activity in the cell.	indirubin-3'-monoxime	66-87	cyclin dependent kinase 1	Homo sapiens	129-133
11180394-6	2001	G2M phase cell accumulations induced in MCF7 cells by L-Ann or Dx were accompanied by a decrease in cdc2 kinase activity and in cyclin B1 and cdc2 expression.	l-ann	54-59	cyclin dependent kinase 1	Homo sapiens	142-146
11180394-7	2001	Conversely, in MDA-MB-435 cells exposed to L-Ann or Dx, cdc2 kinase activity, cyclin B1 and cdc2 expression increased in parallel to the increase in the number of cells accumulated in the G2M phase.	l-ann	43-48	cyclin dependent kinase 1	Homo sapiens	56-60
11180394-7	2001	Conversely, in MDA-MB-435 cells exposed to L-Ann or Dx, cdc2 kinase activity, cyclin B1 and cdc2 expression increased in parallel to the increase in the number of cells accumulated in the G2M phase.	l-ann	43-48	cyclin dependent kinase 1	Homo sapiens	92-96
11455581-8	2001	Only cdc2 expression responds to Znalpha(2)gp, with a reduction of up to over a factor of two.	znalpha	33-40	cyclin dependent kinase 1	Homo sapiens	5-9
11120603-6	2001	In both cell lines, caffeine-induced activation of CDC2 kinase was detected only in cells arrested at G2 and CDC2 kinase-activated cells died exhibiting features of apoptosis.	Caffeine	20-28	cyclin dependent kinase 1	Homo sapiens	109-113
11120603-7	2001	CDC2 kinase activation was inhibited by cycloheximide.	Cycloheximide	40-53	cyclin dependent kinase 1	Homo sapiens	0-4
11120603-8	2001	Furthermore, cycloheximide inhibited activation of CDK2:cyclin A, which normally precedes CDC2 kinase activation in caffeine-treated cells.	Cycloheximide	13-26	cyclin dependent kinase 1	Homo sapiens	90-94
11120603-8	2001	Furthermore, cycloheximide inhibited activation of CDK2:cyclin A, which normally precedes CDC2 kinase activation in caffeine-treated cells.	Caffeine	116-124	cyclin dependent kinase 1	Homo sapiens	90-94
11326318-6	2001	Both these serines are within sequence contexts suitable for proline-directed kinases such as Cdc2.	Serine	11-18	cyclin dependent kinase 1	Homo sapiens	94-98
11113184-1	2001	Cyclin-dependent kinase 7 (CDK7) is the catalytic subunit of the metazoan CDK-activating kinase (CAK), which activates CDKs, such as CDC2 and CDK2, through phosphorylation of a conserved threonine residue in the T loop.	Threonine	187-196	cyclin dependent kinase 1	Homo sapiens	119-123
11113184-1	2001	Cyclin-dependent kinase 7 (CDK7) is the catalytic subunit of the metazoan CDK-activating kinase (CAK), which activates CDKs, such as CDC2 and CDK2, through phosphorylation of a conserved threonine residue in the T loop.	Threonine	187-196	cyclin dependent kinase 1	Homo sapiens	133-137
11113184-3	2001	We show that threonine-170 of CDK7 is phosphorylated in vitro by its targets, CDC2 and CDK2, which also phosphorylate serine-164 in the CDK7 T loop, a site that perfectly matches their consensus phosphorylation site.	Threonine	13-22	cyclin dependent kinase 1	Homo sapiens	78-82
11113184-3	2001	We show that threonine-170 of CDK7 is phosphorylated in vitro by its targets, CDC2 and CDK2, which also phosphorylate serine-164 in the CDK7 T loop, a site that perfectly matches their consensus phosphorylation site.	Serine	118-124	cyclin dependent kinase 1	Homo sapiens	78-82
11272092-7	2001	Exposure to butyrate increases the expression of the cyclin-dependent kinase inhibitors, p21/Cip1 and p27/Kip1, decreases the expression of cyclin A and cyclin B, inhibits the phosphorylation of the retinoblastoma protein (pRb), and decreases the activity of cdk1 and cdk2-associated kinases.	Butyrates	12-20	cyclin dependent kinase 1	Homo sapiens	259-263
11417113-8	2001	It is now reported that CDK1 inhibitory activities of purine analogs correlate with the physiochemical parameters of purine analogs.	purine	54-60	cyclin dependent kinase 1	Homo sapiens	24-28
11417113-8	2001	It is now reported that CDK1 inhibitory activities of purine analogs correlate with the physiochemical parameters of purine analogs.	purine	117-123	cyclin dependent kinase 1	Homo sapiens	24-28
11112337-5	2000	Employing immunoprecipitation kinase assays, we found that ceramide specifically inhibited cyclin-dependent kinase CDK2, with a mild effect on CDC2 and significantly less effect on CDK4.	Ceramides	59-67	cyclin dependent kinase 1	Homo sapiens	143-147
11716438-5	2000	The work allowed us to identify (2-chloroindolyl)methylene-2-indolinone as a new lead of a class of CDK1/cyclinB inhibitors, whose potency can be improved by the introduction of suitable variations on the basic molecular skeleton.	(2-chloroindolyl)methylene-2-indolinone	32-71	cyclin dependent kinase 1	Homo sapiens	100-104
11106571-7	2000	After immunoprecipitation from control and AD tissue, we found that the tyrosine dephosphorylating activity of Cdc25A against exogenous Cdc2 substrate was elevated in AD.	Tyrosine	72-80	cyclin dependent kinase 1	Homo sapiens	111-115
11069302-4	2000	These data identify survivin as a mitotic substrate of p34(cdc2)-cyclin B1 and suggest that survivin phosphorylation on Thr(34) may be required to preserve cell viability at cell division.	Threonine	120-123	cyclin dependent kinase 1	Homo sapiens	59-63
11093360-1	2000	This review focuses on the clinical development of the prototype broad spectrum inhibitor of cyclin-dependent kinases (CDKs), flavopiridol, now undergoing Phase II single-agent trials and Phase I combination trials (with paclitaxel and cisplatin).	Paclitaxel	221-231	cyclin dependent kinase 1	Homo sapiens	119-123
11093360-1	2000	This review focuses on the clinical development of the prototype broad spectrum inhibitor of cyclin-dependent kinases (CDKs), flavopiridol, now undergoing Phase II single-agent trials and Phase I combination trials (with paclitaxel and cisplatin).	Cisplatin	236-245	cyclin dependent kinase 1	Homo sapiens	119-123
11093360-2	2000	Preclinically, flavopiridol is a potent inhibitor of CDKs 1, 2 and 4 in cell-free assays (IC(50)in the region of 100 nM) and tumour cell growth in vitro (typical IC(50)in the region of 100 nM).	alvocidib	15-27	cyclin dependent kinase 1	Homo sapiens	53-68
11329882-3	2000	In this study, we found that butyrolactone I, a specific inhibitor of CDC2 family kinases, blocks the X-ray- or doxorubicin-induced apoptosis of DLD1 (p21+/+) human colorectal carcinoma cells in a dose-dependent manner.	4-Butyrolactone	29-42	cyclin dependent kinase 1	Homo sapiens	70-74
11329882-3	2000	In this study, we found that butyrolactone I, a specific inhibitor of CDC2 family kinases, blocks the X-ray- or doxorubicin-induced apoptosis of DLD1 (p21+/+) human colorectal carcinoma cells in a dose-dependent manner.	Doxorubicin	112-123	cyclin dependent kinase 1	Homo sapiens	70-74
11191351-5	2000	Due to the deficiency of p34cdc2 and Cyclin B1, the spermatogonia and pachytene/diplotene primary spermatocytes were unable to form MPF, hence, they couldn"t undergo karyokinesis.	pachytene	70-79	cyclin dependent kinase 1	Homo sapiens	25-32
11191351-5	2000	Due to the deficiency of p34cdc2 and Cyclin B1, the spermatogonia and pachytene/diplotene primary spermatocytes were unable to form MPF, hence, they couldn"t undergo karyokinesis.	diplotene	80-89	cyclin dependent kinase 1	Homo sapiens	25-32
10973963-12	2000	Alanine substitutions in the region abolished GADD45 induction of a G(2)/M arrest and its inactivation of the Cdc2 kinase but not its binding to Cdc2, PCNA, or p21(waf1).	Alanine	0-7	cyclin dependent kinase 1	Homo sapiens	110-114
11205291-0	2000	Up-regulation of cyclin B1 and cdc2 expression during 9-nitrocamptothecin-induced regression of DU145 prostate tumor.	rubitecan	54-73	cyclin dependent kinase 1	Homo sapiens	31-35
11063609-1	2000	Flavopiridol analogues, thio- and oxoflavopiridols which contain a sulfur (16) or oxygen (18) atom linker between a chromone ring and the hydrophobic side chain, are selective cyclin-dependent kinase 1 (CDK1) inhibitors with an IC(50) of 110 and 130 nM.	alvocidib	0-12	cyclin dependent kinase 1	Homo sapiens	176-201
11063609-1	2000	Flavopiridol analogues, thio- and oxoflavopiridols which contain a sulfur (16) or oxygen (18) atom linker between a chromone ring and the hydrophobic side chain, are selective cyclin-dependent kinase 1 (CDK1) inhibitors with an IC(50) of 110 and 130 nM.	alvocidib	0-12	cyclin dependent kinase 1	Homo sapiens	203-207
11063609-1	2000	Flavopiridol analogues, thio- and oxoflavopiridols which contain a sulfur (16) or oxygen (18) atom linker between a chromone ring and the hydrophobic side chain, are selective cyclin-dependent kinase 1 (CDK1) inhibitors with an IC(50) of 110 and 130 nM.	Sulfur	67-73	cyclin dependent kinase 1	Homo sapiens	176-201
11063609-1	2000	Flavopiridol analogues, thio- and oxoflavopiridols which contain a sulfur (16) or oxygen (18) atom linker between a chromone ring and the hydrophobic side chain, are selective cyclin-dependent kinase 1 (CDK1) inhibitors with an IC(50) of 110 and 130 nM.	Sulfur	67-73	cyclin dependent kinase 1	Homo sapiens	203-207
11063609-1	2000	Flavopiridol analogues, thio- and oxoflavopiridols which contain a sulfur (16) or oxygen (18) atom linker between a chromone ring and the hydrophobic side chain, are selective cyclin-dependent kinase 1 (CDK1) inhibitors with an IC(50) of 110 and 130 nM.	Oxygen	82-88	cyclin dependent kinase 1	Homo sapiens	176-201
11063609-1	2000	Flavopiridol analogues, thio- and oxoflavopiridols which contain a sulfur (16) or oxygen (18) atom linker between a chromone ring and the hydrophobic side chain, are selective cyclin-dependent kinase 1 (CDK1) inhibitors with an IC(50) of 110 and 130 nM.	Oxygen	82-88	cyclin dependent kinase 1	Homo sapiens	203-207
11063609-1	2000	Flavopiridol analogues, thio- and oxoflavopiridols which contain a sulfur (16) or oxygen (18) atom linker between a chromone ring and the hydrophobic side chain, are selective cyclin-dependent kinase 1 (CDK1) inhibitors with an IC(50) of 110 and 130 nM.	Chromones	116-124	cyclin dependent kinase 1	Homo sapiens	176-201
11063609-1	2000	Flavopiridol analogues, thio- and oxoflavopiridols which contain a sulfur (16) or oxygen (18) atom linker between a chromone ring and the hydrophobic side chain, are selective cyclin-dependent kinase 1 (CDK1) inhibitors with an IC(50) of 110 and 130 nM.	Chromones	116-124	cyclin dependent kinase 1	Homo sapiens	203-207
11063609-4	2000	Hydrophobic side chains such as chlorophenyl or tert-butyl produced potent CDK1 inhibitory activity, while hydrophilic side chains such as pyrimidine or aniline caused a severe reduction in CDK inhibitory activity.	chlorophenyl	32-44	cyclin dependent kinase 1	Homo sapiens	75-79
11063609-4	2000	Hydrophobic side chains such as chlorophenyl or tert-butyl produced potent CDK1 inhibitory activity, while hydrophilic side chains such as pyrimidine or aniline caused a severe reduction in CDK inhibitory activity.	tert-butyl	48-58	cyclin dependent kinase 1	Homo sapiens	75-79
11063609-7	2000	CDK1 selective thio- and oxoflavopiridol analogues inhibit the colony-forming ability of multiple human tumor cell lines and possess a unique antiproliferative profile in comparison to flavopiridol.	alvocidib	28-40	cyclin dependent kinase 1	Homo sapiens	0-4
11027648-5	2000	However, we observed an accumulation of tyrosine 15 hyperphosphorylated cyclin B-cdc2 complex.	Tyrosine	40-48	cyclin dependent kinase 1	Homo sapiens	81-85
11024179-0	2000	Cell cycle-independent removal of UV-induced pyrimidine dimers from the promoter and the transcription initiation domain of the human CDC2 gene.	pyrimidine	45-55	cyclin dependent kinase 1	Homo sapiens	134-138
11027648-7	2000	Chk1 phosphorylates cdc25C on serine 216 and inactivates it whereas cdc25C dephosphorylates tyrosine 15 phosphate of cdc2 and activates the cdc2-cyclin B complex.	Serine	30-36	cyclin dependent kinase 1	Homo sapiens	20-24
11027648-7	2000	Chk1 phosphorylates cdc25C on serine 216 and inactivates it whereas cdc25C dephosphorylates tyrosine 15 phosphate of cdc2 and activates the cdc2-cyclin B complex.	Tyrosine	92-100	cyclin dependent kinase 1	Homo sapiens	68-72
11027648-7	2000	Chk1 phosphorylates cdc25C on serine 216 and inactivates it whereas cdc25C dephosphorylates tyrosine 15 phosphate of cdc2 and activates the cdc2-cyclin B complex.	Phosphates	104-113	cyclin dependent kinase 1	Homo sapiens	68-72
10998356-2	2000	We have shown previously that the protein kinase CKII catalyses the phosphorylation of Ser-39 in Cdc2 during the G(1) phase of the HeLa cell-division cycle [Russo, Vandenberg, Yu, Bae, Franza and Marshak (1992) J. Biol.	Serine	87-90	cyclin dependent kinase 1	Homo sapiens	97-101
10998356-6	2000	The S. cerevisiae homologue of Cdc2, Cdc28, contains a consensus CKII site (Ser-46), which is homologous with that of human Cdc2.	Serine	76-79	cyclin dependent kinase 1	Homo sapiens	31-35
10998356-6	2000	The S. cerevisiae homologue of Cdc2, Cdc28, contains a consensus CKII site (Ser-46), which is homologous with that of human Cdc2.	Serine	76-79	cyclin dependent kinase 1	Homo sapiens	37-41
10956385-0	2000	Up-regulation of cdc2 protein during paclitaxel-induced apoptosis.	Paclitaxel	37-47	cyclin dependent kinase 1	Homo sapiens	17-21
10913154-3	2000	We show that p21 blocks the activating phosphorylation of Cdc2 on Thr(161).	Threonine	66-69	cyclin dependent kinase 1	Homo sapiens	58-62
10846177-1	2000	In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks.	Threonine	94-103	cyclin dependent kinase 1	Homo sapiens	123-127
10846177-16	2000	In vitro, Cdk2-Cyclin E, Cdk2-Cyclin A, and Cdc2-Cyclin B, but not Cdk4-Cyclin D1, phosphorylates the Thr-376 residue of huCdc7, suggesting possible regulation of huCdc7 by Cdks.	Threonine	102-105	cyclin dependent kinase 1	Homo sapiens	44-48
10846177-16	2000	In vitro, Cdk2-Cyclin E, Cdk2-Cyclin A, and Cdc2-Cyclin B, but not Cdk4-Cyclin D1, phosphorylates the Thr-376 residue of huCdc7, suggesting possible regulation of huCdc7 by Cdks.	Threonine	102-105	cyclin dependent kinase 1	Homo sapiens	173-177
11029659-1	2000	BACKGROUND: In eukaryotic cells, the kinase activity of the mitosis-promoting complex composed of cyclin B and Cdc2 (Cdk1) is negatively regulated by the phosphorylation of Cdk1 on threonine or tyrosine residues within its ATP binding domain.	Threonine	181-190	cyclin dependent kinase 1	Homo sapiens	111-115
11029659-1	2000	BACKGROUND: In eukaryotic cells, the kinase activity of the mitosis-promoting complex composed of cyclin B and Cdc2 (Cdk1) is negatively regulated by the phosphorylation of Cdk1 on threonine or tyrosine residues within its ATP binding domain.	Threonine	181-190	cyclin dependent kinase 1	Homo sapiens	117-121
11029659-1	2000	BACKGROUND: In eukaryotic cells, the kinase activity of the mitosis-promoting complex composed of cyclin B and Cdc2 (Cdk1) is negatively regulated by the phosphorylation of Cdk1 on threonine or tyrosine residues within its ATP binding domain.	Threonine	181-190	cyclin dependent kinase 1	Homo sapiens	173-177
11029659-1	2000	BACKGROUND: In eukaryotic cells, the kinase activity of the mitosis-promoting complex composed of cyclin B and Cdc2 (Cdk1) is negatively regulated by the phosphorylation of Cdk1 on threonine or tyrosine residues within its ATP binding domain.	Tyrosine	194-202	cyclin dependent kinase 1	Homo sapiens	111-115
11029659-1	2000	BACKGROUND: In eukaryotic cells, the kinase activity of the mitosis-promoting complex composed of cyclin B and Cdc2 (Cdk1) is negatively regulated by the phosphorylation of Cdk1 on threonine or tyrosine residues within its ATP binding domain.	Tyrosine	194-202	cyclin dependent kinase 1	Homo sapiens	117-121
11029659-1	2000	BACKGROUND: In eukaryotic cells, the kinase activity of the mitosis-promoting complex composed of cyclin B and Cdc2 (Cdk1) is negatively regulated by the phosphorylation of Cdk1 on threonine or tyrosine residues within its ATP binding domain.	Tyrosine	194-202	cyclin dependent kinase 1	Homo sapiens	173-177
11029659-1	2000	BACKGROUND: In eukaryotic cells, the kinase activity of the mitosis-promoting complex composed of cyclin B and Cdc2 (Cdk1) is negatively regulated by the phosphorylation of Cdk1 on threonine or tyrosine residues within its ATP binding domain.	Adenosine Triphosphate	223-226	cyclin dependent kinase 1	Homo sapiens	111-115
11029659-1	2000	BACKGROUND: In eukaryotic cells, the kinase activity of the mitosis-promoting complex composed of cyclin B and Cdc2 (Cdk1) is negatively regulated by the phosphorylation of Cdk1 on threonine or tyrosine residues within its ATP binding domain.	Adenosine Triphosphate	223-226	cyclin dependent kinase 1	Homo sapiens	117-121
11029659-1	2000	BACKGROUND: In eukaryotic cells, the kinase activity of the mitosis-promoting complex composed of cyclin B and Cdc2 (Cdk1) is negatively regulated by the phosphorylation of Cdk1 on threonine or tyrosine residues within its ATP binding domain.	Adenosine Triphosphate	223-226	cyclin dependent kinase 1	Homo sapiens	173-177
11029659-8	2000	Recombinant Wee1B effectively phosphorylated cyclin B-associated Cdk1 on tyrosine-15, resulting in an inactivation of the kinase activity of Cdk1.	Tyrosine	73-81	cyclin dependent kinase 1	Homo sapiens	65-69
11029659-8	2000	Recombinant Wee1B effectively phosphorylated cyclin B-associated Cdk1 on tyrosine-15, resulting in an inactivation of the kinase activity of Cdk1.	Tyrosine	73-81	cyclin dependent kinase 1	Homo sapiens	141-145
10956385-1	2000	Microtubule damages induced by paclitaxel inhibit proteasome-dependent degradation of cyclin B, resulting in a sustained activation of cyclin B/cdc2 kinase and a cell cycle arrest in mitosis.	Paclitaxel	31-41	cyclin dependent kinase 1	Homo sapiens	144-148
10956385-3	2000	We found here that paclitaxel increased cdc2 mRNA and protein levels and led to an accumulation of cdc2 in the active dephosphorylated form in NIH-OVCAR-3 cells.	Paclitaxel	19-29	cyclin dependent kinase 1	Homo sapiens	40-44
10956385-3	2000	We found here that paclitaxel increased cdc2 mRNA and protein levels and led to an accumulation of cdc2 in the active dephosphorylated form in NIH-OVCAR-3 cells.	Paclitaxel	19-29	cyclin dependent kinase 1	Homo sapiens	99-103
10956385-4	2000	The addition of cycloheximide inhibited the paclitaxel-induced increase in cdc2 protein level, further indicating that paclitaxel stimulates cdc2 synthesis.	Cycloheximide	16-29	cyclin dependent kinase 1	Homo sapiens	75-79
10956385-4	2000	The addition of cycloheximide inhibited the paclitaxel-induced increase in cdc2 protein level, further indicating that paclitaxel stimulates cdc2 synthesis.	Cycloheximide	16-29	cyclin dependent kinase 1	Homo sapiens	141-145
10956385-4	2000	The addition of cycloheximide inhibited the paclitaxel-induced increase in cdc2 protein level, further indicating that paclitaxel stimulates cdc2 synthesis.	Paclitaxel	44-54	cyclin dependent kinase 1	Homo sapiens	75-79
10956385-4	2000	The addition of cycloheximide inhibited the paclitaxel-induced increase in cdc2 protein level, further indicating that paclitaxel stimulates cdc2 synthesis.	Paclitaxel	44-54	cyclin dependent kinase 1	Homo sapiens	141-145
10956385-4	2000	The addition of cycloheximide inhibited the paclitaxel-induced increase in cdc2 protein level, further indicating that paclitaxel stimulates cdc2 synthesis.	Paclitaxel	119-129	cyclin dependent kinase 1	Homo sapiens	75-79
10956385-4	2000	The addition of cycloheximide inhibited the paclitaxel-induced increase in cdc2 protein level, further indicating that paclitaxel stimulates cdc2 synthesis.	Paclitaxel	119-129	cyclin dependent kinase 1	Homo sapiens	141-145
10956385-5	2000	This increase in cdc2 synthesis is a consequence of paclitaxel-induced arrest in mitosis.	Paclitaxel	52-62	cyclin dependent kinase 1	Homo sapiens	17-21
10956385-8	2000	In addition, when paclitaxel-induced apoptosis was inhibited by Bcl-2 over-expression, cdc2 up-regulation did not occur, leading to a lower level of activation of the cyclin B/cdc2 complex.	Paclitaxel	18-28	cyclin dependent kinase 1	Homo sapiens	87-91
10956385-8	2000	In addition, when paclitaxel-induced apoptosis was inhibited by Bcl-2 over-expression, cdc2 up-regulation did not occur, leading to a lower level of activation of the cyclin B/cdc2 complex.	Paclitaxel	18-28	cyclin dependent kinase 1	Homo sapiens	176-180
10956385-9	2000	Taken together, these results indicated that paclitaxel-induced cdc2 protein synthesis participates in a positive feedback loop designed to increase the activity of cyclin B/cdc2 kinase and thus may play a role in paclitaxel-induced apoptosis.	Paclitaxel	45-55	cyclin dependent kinase 1	Homo sapiens	64-68
10956385-9	2000	Taken together, these results indicated that paclitaxel-induced cdc2 protein synthesis participates in a positive feedback loop designed to increase the activity of cyclin B/cdc2 kinase and thus may play a role in paclitaxel-induced apoptosis.	Paclitaxel	45-55	cyclin dependent kinase 1	Homo sapiens	174-178
10956385-9	2000	Taken together, these results indicated that paclitaxel-induced cdc2 protein synthesis participates in a positive feedback loop designed to increase the activity of cyclin B/cdc2 kinase and thus may play a role in paclitaxel-induced apoptosis.	Paclitaxel	214-224	cyclin dependent kinase 1	Homo sapiens	64-68
10956385-9	2000	Taken together, these results indicated that paclitaxel-induced cdc2 protein synthesis participates in a positive feedback loop designed to increase the activity of cyclin B/cdc2 kinase and thus may play a role in paclitaxel-induced apoptosis.	Paclitaxel	214-224	cyclin dependent kinase 1	Homo sapiens	174-178
11021638-3	2000	Northern analysis of butyrate- and TSA-treated root meristems indicated that non-proliferating cells are expressing significant amounts of transcripts of the known cell proliferation associated genes: histone H2A, MAP kinase, cycA2:1 and cdc2.	Butyrates	21-29	cyclin dependent kinase 1	Homo sapiens	238-242
10938379-6	2000	An increased level of cdc2 tyrosine-15 phosphorylation following H2O2 treatment suggests that the observed growth arrest is mediated by a G2 checkpoint mechanism.	Hydrogen Peroxide	65-69	cyclin dependent kinase 1	Homo sapiens	22-26
10996850-8	2000	With exception of the T47D cell line, we revealed an increase in the tyrosine phosphorylated form of p34, suggesting an inactivation of the p34(cdc-2) catalytic activity consequent to treatment of cells with genistein.	Genistein	208-217	cyclin dependent kinase 1	Homo sapiens	144-149
11021638-3	2000	Northern analysis of butyrate- and TSA-treated root meristems indicated that non-proliferating cells are expressing significant amounts of transcripts of the known cell proliferation associated genes: histone H2A, MAP kinase, cycA2:1 and cdc2.	trichostatin A	35-38	cyclin dependent kinase 1	Homo sapiens	238-242
10727901-4	2000	In unstimulated HPBL, PCC was induced by the addition of p34(cdc2)/cyclin B kinase at concentrations as low as 5 units/ml to a cell culture medium containing OA.	pyridinium chlorochromate	22-25	cyclin dependent kinase 1	Homo sapiens	61-65
10956187-1	2000	Substituted guanines and pyrimidines were tested as inhibitors of cyclin B1/CDK1 and cyclin A3/CDK2 and soaked into crystals of monomeric CDK2.	Guanine	12-20	cyclin dependent kinase 1	Homo sapiens	76-80
10956187-2	2000	O6-Cyclohexylmethylguanine (NU2058) was a competitive inhibitor of CDK1 and CDK2 with respect to ATP (Ki values: CDK1, 5 +/- 1 microM; CDK2, 12 +/- 3 microM) and formed a triplet of hydrogen bonds (i.e., NH-9 to Glu 81, N-3 to Leu 83, and 2-NH2 to Leu 83).	NU2058	0-26	cyclin dependent kinase 1	Homo sapiens	67-71
10956187-2	2000	O6-Cyclohexylmethylguanine (NU2058) was a competitive inhibitor of CDK1 and CDK2 with respect to ATP (Ki values: CDK1, 5 +/- 1 microM; CDK2, 12 +/- 3 microM) and formed a triplet of hydrogen bonds (i.e., NH-9 to Glu 81, N-3 to Leu 83, and 2-NH2 to Leu 83).	NU2058	0-26	cyclin dependent kinase 1	Homo sapiens	113-117
10956187-2	2000	O6-Cyclohexylmethylguanine (NU2058) was a competitive inhibitor of CDK1 and CDK2 with respect to ATP (Ki values: CDK1, 5 +/- 1 microM; CDK2, 12 +/- 3 microM) and formed a triplet of hydrogen bonds (i.e., NH-9 to Glu 81, N-3 to Leu 83, and 2-NH2 to Leu 83).	NU2058	28-34	cyclin dependent kinase 1	Homo sapiens	67-71
10956187-2	2000	O6-Cyclohexylmethylguanine (NU2058) was a competitive inhibitor of CDK1 and CDK2 with respect to ATP (Ki values: CDK1, 5 +/- 1 microM; CDK2, 12 +/- 3 microM) and formed a triplet of hydrogen bonds (i.e., NH-9 to Glu 81, N-3 to Leu 83, and 2-NH2 to Leu 83).	NU2058	28-34	cyclin dependent kinase 1	Homo sapiens	113-117
10956187-2	2000	O6-Cyclohexylmethylguanine (NU2058) was a competitive inhibitor of CDK1 and CDK2 with respect to ATP (Ki values: CDK1, 5 +/- 1 microM; CDK2, 12 +/- 3 microM) and formed a triplet of hydrogen bonds (i.e., NH-9 to Glu 81, N-3 to Leu 83, and 2-NH2 to Leu 83).	Adenosine Triphosphate	97-100	cyclin dependent kinase 1	Homo sapiens	67-71
10956187-2	2000	O6-Cyclohexylmethylguanine (NU2058) was a competitive inhibitor of CDK1 and CDK2 with respect to ATP (Ki values: CDK1, 5 +/- 1 microM; CDK2, 12 +/- 3 microM) and formed a triplet of hydrogen bonds (i.e., NH-9 to Glu 81, N-3 to Leu 83, and 2-NH2 to Leu 83).	Hydrogen	182-190	cyclin dependent kinase 1	Homo sapiens	67-71
10956187-2	2000	O6-Cyclohexylmethylguanine (NU2058) was a competitive inhibitor of CDK1 and CDK2 with respect to ATP (Ki values: CDK1, 5 +/- 1 microM; CDK2, 12 +/- 3 microM) and formed a triplet of hydrogen bonds (i.e., NH-9 to Glu 81, N-3 to Leu 83, and 2-NH2 to Leu 83).	Glutamic Acid	212-215	cyclin dependent kinase 1	Homo sapiens	67-71
10956187-2	2000	O6-Cyclohexylmethylguanine (NU2058) was a competitive inhibitor of CDK1 and CDK2 with respect to ATP (Ki values: CDK1, 5 +/- 1 microM; CDK2, 12 +/- 3 microM) and formed a triplet of hydrogen bonds (i.e., NH-9 to Glu 81, N-3 to Leu 83, and 2-NH2 to Leu 83).	Leucine	227-230	cyclin dependent kinase 1	Homo sapiens	67-71
10956187-2	2000	O6-Cyclohexylmethylguanine (NU2058) was a competitive inhibitor of CDK1 and CDK2 with respect to ATP (Ki values: CDK1, 5 +/- 1 microM; CDK2, 12 +/- 3 microM) and formed a triplet of hydrogen bonds (i.e., NH-9 to Glu 81, N-3 to Leu 83, and 2-NH2 to Leu 83).	Leucine	248-251	cyclin dependent kinase 1	Homo sapiens	67-71
10956187-3	2000	The triplet of hydrogen bonding and CDK inhibition was reproduced by 2,6-diamino-4-cyclohexylmethyloxy-5-nitrosopyrimidine (NU6027, Ki values: CDK1, 2.5 +/- 0.4 microM; CDK2, 1.3 +/- 0.2 microM).	Hydrogen	15-23	cyclin dependent kinase 1	Homo sapiens	143-147
10766756-3	2000	When CDC2 was activated by okadaic acid in HL-60 cells, Bcl-2 phosphorylation was readily induced.	Okadaic Acid	27-39	cyclin dependent kinase 1	Homo sapiens	5-9
10766756-7	2000	Using synthetic peptides and mutant cell lines, we identified threonine 56, one of two consensus sites for CDC2 within the Bcl-2 sequence, as a residue phosphorylated by CDC2.	Threonine	62-71	cyclin dependent kinase 1	Homo sapiens	107-111
10766756-7	2000	Using synthetic peptides and mutant cell lines, we identified threonine 56, one of two consensus sites for CDC2 within the Bcl-2 sequence, as a residue phosphorylated by CDC2.	Threonine	62-71	cyclin dependent kinase 1	Homo sapiens	170-174
10896313-0	2000	Structure-based design of potent CDK1 inhibitors derived from olomoucine.	olomoucine	62-72	cyclin dependent kinase 1	Homo sapiens	33-37
10770932-5	2000	We show that bFGF treatment inhibits Tyr-15 dephosphorylation of cdc2 and prevents activation of Cdc25C, similar to what is seen upon activation of the G(2) DNA damage checkpoint.	Tyrosine	37-40	cyclin dependent kinase 1	Homo sapiens	65-69
10770932-6	2000	Interestingly, both DNA damage- and bFGF-induced effects on cdc2 phosphorylation are reverted by caffeine.	Caffeine	97-105	cyclin dependent kinase 1	Homo sapiens	60-64
11225845-0	2000	Activation of MAD 2 checkprotein and persistence of cyclin B1/CDC 2 activity associate with paclitaxel-induced apoptosis in human nasopharyngeal carcinoma cells.	Paclitaxel	92-102	cyclin dependent kinase 1	Homo sapiens	62-67
11225845-2	2000	In this study, we intended to explore the underlying molecular events and found that cellular cyclin B1/CDC 2 kinase activity was increased and persisted for &gt;6 h upon paclitaxel treatment both at high and low concentrations.	Paclitaxel	171-181	cyclin dependent kinase 1	Homo sapiens	104-109
11225845-6	2000	Our study suggests that activation of cyclin B1/CDC 2 and MAD 2 were the M-phase events required for paclitaxel-induced apoptosis in NPC cells.	Paclitaxel	101-111	cyclin dependent kinase 1	Homo sapiens	48-53
10837000-9	2000	The present studies suggest that the ability of DADS to inhibit p34(cdc2) kinase activation occurs because of decreased p34(cdc2)/cyclin B(1) complex formation and modest p34(cdc2) hyperphosphorylation.	diallyl disulfide	48-52	cyclin dependent kinase 1	Homo sapiens	124-128
10850458-5	2000	Western blot analysis demonstrated that treatment with As2O3 (2 microM) for 72 h did not change the steady-state levels of CDK2, CDK4, cyclin D1, cyclin E, and cyclin B1 but decreased the levels of CDK6, cdc2, and cyclin A.	Arsenic Trioxide	55-60	cyclin dependent kinase 1	Homo sapiens	204-208
10850458-7	2000	In addition, As2O3 markedly enhanced the binding of p21 with CDK6, cdc2, cyclin E, and cyclin A compared with untreated control cells.	Arsenic Trioxide	13-18	cyclin dependent kinase 1	Homo sapiens	67-71
10886374-1	2000	BACKGROUND: Activation of the cyclin-dependent kinase cdc2-cyclin B1 at the G2/M transition of the cell cycle requires dephosphorylation of threonine-14 and tyrosine-15 in cdc2, which in higher eukaryotes is brought about by the Cdc25C phosphatase.	Threonine	140-149	cyclin dependent kinase 1	Homo sapiens	54-58
10886374-1	2000	BACKGROUND: Activation of the cyclin-dependent kinase cdc2-cyclin B1 at the G2/M transition of the cell cycle requires dephosphorylation of threonine-14 and tyrosine-15 in cdc2, which in higher eukaryotes is brought about by the Cdc25C phosphatase.	Threonine	140-149	cyclin dependent kinase 1	Homo sapiens	172-176
10886374-1	2000	BACKGROUND: Activation of the cyclin-dependent kinase cdc2-cyclin B1 at the G2/M transition of the cell cycle requires dephosphorylation of threonine-14 and tyrosine-15 in cdc2, which in higher eukaryotes is brought about by the Cdc25C phosphatase.	Tyrosine	157-165	cyclin dependent kinase 1	Homo sapiens	54-58
10886374-1	2000	BACKGROUND: Activation of the cyclin-dependent kinase cdc2-cyclin B1 at the G2/M transition of the cell cycle requires dephosphorylation of threonine-14 and tyrosine-15 in cdc2, which in higher eukaryotes is brought about by the Cdc25C phosphatase.	Tyrosine	157-165	cyclin dependent kinase 1	Homo sapiens	172-176
10854050-4	2000	Here we demonstrate biochemically that cdc2/cyclin B1 accumulates at the centrosome in late G2 as the inactive, phosphotyrosine 15 form and that the centrosomal cdc2/cyclin B1 can be activated in vitro by recombinant cdc25B.	Phosphotyrosine	112-127	cyclin dependent kinase 1	Homo sapiens	39-43
10854050-5	2000	We provide evidence that a portion of the cdc2/cyclin B1 translocated into the nucleus in prophase is the inactive tyrosine-15-phosphorylated form.	Tyrosine	115-123	cyclin dependent kinase 1	Homo sapiens	42-46
10956187-3	2000	The triplet of hydrogen bonding and CDK inhibition was reproduced by 2,6-diamino-4-cyclohexylmethyloxy-5-nitrosopyrimidine (NU6027, Ki values: CDK1, 2.5 +/- 0.4 microM; CDK2, 1.3 +/- 0.2 microM).	2,6-diamino-4-cyclohexylmethyloxy-5-nitrosopyrimidine	69-122	cyclin dependent kinase 1	Homo sapiens	143-147
10956187-3	2000	The triplet of hydrogen bonding and CDK inhibition was reproduced by 2,6-diamino-4-cyclohexylmethyloxy-5-nitrosopyrimidine (NU6027, Ki values: CDK1, 2.5 +/- 0.4 microM; CDK2, 1.3 +/- 0.2 microM).	4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine	124-130	cyclin dependent kinase 1	Homo sapiens	143-147
10896848-12	2000	We conclude that HPAEC treated with low concentrations of MCTP develop G2 arrest in association with persistent cyclin B1 expression, failure to completely activate cdc2, and continued DNA synthesis through a pathway that is unrelated to altered expression of p53.	monocrotaline pyrrole	58-62	cyclin dependent kinase 1	Homo sapiens	165-169
10912792-4	2000	However, while CDK1 activity was markedly reduced following genistein treatment, CDK2 activity was not affected.	Genistein	60-69	cyclin dependent kinase 1	Homo sapiens	15-19
10912792-8	2000	The role of p21CIP1 in the inhibition of CDK1 was questionable, as we demonstrated that genistein impaired Tyr15 dephosphorylation of CDK1 and because CDK1-cyclin B1 complexes from treated cells could be reactivated upon exposure to CDC25 phosphatase.	Genistein	88-97	cyclin dependent kinase 1	Homo sapiens	134-138
10912792-8	2000	The role of p21CIP1 in the inhibition of CDK1 was questionable, as we demonstrated that genistein impaired Tyr15 dephosphorylation of CDK1 and because CDK1-cyclin B1 complexes from treated cells could be reactivated upon exposure to CDC25 phosphatase.	Genistein	88-97	cyclin dependent kinase 1	Homo sapiens	134-138
10958988-5	2000	A strain with a mutation changing the Tyr15 of Cdc2 to the non-phosphorylated Phe (Y15F) eliminated Vpr-induced G2 arrest indicating that Tyr15 of Cdc2 is the sole target for induction of G2 arrest by Vpr.	Phenylalanine	78-81	cyclin dependent kinase 1	Homo sapiens	47-51
10958988-5	2000	A strain with a mutation changing the Tyr15 of Cdc2 to the non-phosphorylated Phe (Y15F) eliminated Vpr-induced G2 arrest indicating that Tyr15 of Cdc2 is the sole target for induction of G2 arrest by Vpr.	Phenylalanine	78-81	cyclin dependent kinase 1	Homo sapiens	147-151
10837000-0	2000	Diallyl disulfide inhibits p34(cdc2) kinase activity through changes in complex formation and phosphorylation.	diallyl disulfide	0-17	cyclin dependent kinase 1	Homo sapiens	31-35
10837000-1	2000	Previous studies from our laboratory demonstrated that diallyl disulfide (DADS), an oil-soluble allyl sulfur compound found in processed garlic, markedly suppressed p34(cdc2) kinase activity and induced a G(2)/M phase arrest in cultured human colon tumor (HCT-15) cells.	diallyl disulfide	55-72	cyclin dependent kinase 1	Homo sapiens	169-173
10837000-1	2000	Previous studies from our laboratory demonstrated that diallyl disulfide (DADS), an oil-soluble allyl sulfur compound found in processed garlic, markedly suppressed p34(cdc2) kinase activity and induced a G(2)/M phase arrest in cultured human colon tumor (HCT-15) cells.	diallyl disulfide	74-78	cyclin dependent kinase 1	Homo sapiens	169-173
10837000-1	2000	Previous studies from our laboratory demonstrated that diallyl disulfide (DADS), an oil-soluble allyl sulfur compound found in processed garlic, markedly suppressed p34(cdc2) kinase activity and induced a G(2)/M phase arrest in cultured human colon tumor (HCT-15) cells.	allyl	57-62	cyclin dependent kinase 1	Homo sapiens	169-173
10837000-6	2000	Exposure of unsynchronized cells to 25 or 50 microM DADS caused a trend towards increased p34(cdc2) hyperphosphorylation (17 and 22%, respectively).	diallyl disulfide	52-56	cyclin dependent kinase 1	Homo sapiens	94-98
10837000-7	2000	Exposure of synchronized cells to 100 microM DADS increased p34(cdc2) hyperphosphorylation by 15% (P &lt; 0.05).	diallyl disulfide	45-49	cyclin dependent kinase 1	Homo sapiens	64-68
10837000-8	2000	Consistent with its ability to slightly increase the quantity of hyperphosphorylated p34(cdc2), DADS, 25 or 50 microM, decreased cdc25C protein expression by 23 and 46%, respectively (P &lt; 0.05).	diallyl disulfide	96-100	cyclin dependent kinase 1	Homo sapiens	89-93
10837000-9	2000	The present studies suggest that the ability of DADS to inhibit p34(cdc2) kinase activation occurs because of decreased p34(cdc2)/cyclin B(1) complex formation and modest p34(cdc2) hyperphosphorylation.	diallyl disulfide	48-52	cyclin dependent kinase 1	Homo sapiens	68-72
10837000-9	2000	The present studies suggest that the ability of DADS to inhibit p34(cdc2) kinase activation occurs because of decreased p34(cdc2)/cyclin B(1) complex formation and modest p34(cdc2) hyperphosphorylation.	diallyl disulfide	48-52	cyclin dependent kinase 1	Homo sapiens	124-128
10809772-3	2000	Here we show that genistein exerts this effect by impairing the Cdc25C-dependent Tyr-15 dephosphorylation of Cdk1, as the overexpression of this phosphatase allows the cells to escape G(2) arrest and enter an abnormal chromatin condensation stage.	Tyrosine	81-84	cyclin dependent kinase 1	Homo sapiens	109-113
10810342-7	2000	Paclitaxel treatment gradually and significantly blocked cell-cycle progression at G2/M phase and increased the accumulation of cyclin B1 and cdc2 in H358 cells.	Paclitaxel	0-10	cyclin dependent kinase 1	Homo sapiens	142-146
10741555-0	2000	2-Substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity.	2-substituted paullones	0-23	cyclin dependent kinase 1	Homo sapiens	25-29
10788588-6	2000	Potent specific inhibitors have been identified that bind to the ATP site of CDKs, mainly cyclin B-CDK1, cyclin A-CDK2, and cyclin D-CDK4 complexes, and inhibit kinase activity.	Adenosine Triphosphate	65-68	cyclin dependent kinase 1	Homo sapiens	77-81
10788588-6	2000	Potent specific inhibitors have been identified that bind to the ATP site of CDKs, mainly cyclin B-CDK1, cyclin A-CDK2, and cyclin D-CDK4 complexes, and inhibit kinase activity.	Adenosine Triphosphate	65-68	cyclin dependent kinase 1	Homo sapiens	99-103
10683156-3	2000	Arrested cells accumulate cyclin B, the regulatory partner of the mitotic p34(cdc2) kinase, which is normally not abundant until late G(2) phase; treatment of arrested cells with caffeine produces rapid S-phase condensation.	Caffeine	179-187	cyclin dependent kinase 1	Homo sapiens	78-82
10683156-7	2000	Addition of deoxyribonucleosides shows that rapid S-phase condensation is suppressed by a novel checkpoint mechanism: purine (but not pyrimidine) deoxyribonucleosides, like reverse transformation, suppress cyclin B/p34(cdc2) activation by caffeine, but not cyclin B accumulation.	purine	118-124	cyclin dependent kinase 1	Homo sapiens	219-223
10683156-7	2000	Addition of deoxyribonucleosides shows that rapid S-phase condensation is suppressed by a novel checkpoint mechanism: purine (but not pyrimidine) deoxyribonucleosides, like reverse transformation, suppress cyclin B/p34(cdc2) activation by caffeine, but not cyclin B accumulation.	Deoxyribonucleosides	146-166	cyclin dependent kinase 1	Homo sapiens	219-223
10888036-1	2000	A congeneric series of paullones were characterized using a 3-D QSAR with cyclin-dependent kinase 1 (CDK1) inhibition data.	paullone	23-32	cyclin dependent kinase 1	Homo sapiens	74-99
10681541-3	2000	In most species, the G(2) checkpoint prevents the Cdc25 phosphatase from removing inhibitory phosphate groups from the mitosis-promoting kinase Cdc2.	Phosphates	93-102	cyclin dependent kinase 1	Homo sapiens	50-54
10888036-1	2000	A congeneric series of paullones were characterized using a 3-D QSAR with cyclin-dependent kinase 1 (CDK1) inhibition data.	paullone	23-32	cyclin dependent kinase 1	Homo sapiens	101-105
10888036-3	2000	Paullones were docked into the ATP binding site of the CDK1-cylin B models and were optimized with molecular mechanics.	paullone	0-9	cyclin dependent kinase 1	Homo sapiens	55-59
10888036-3	2000	Paullones were docked into the ATP binding site of the CDK1-cylin B models and were optimized with molecular mechanics.	Adenosine Triphosphate	31-34	cyclin dependent kinase 1	Homo sapiens	55-59
10888036-8	2000	Compounds with low affinity for CDK1 were poor charge acceptors and made less than ideal hydrogen bonding arrangements with the receptor.	Hydrogen	89-97	cyclin dependent kinase 1	Homo sapiens	32-36
10761703-6	2000	Following genistein treatment of cells, an increased binding of p21 with Cdk2 and Cdc2 paralleled a significant decrease in Cdc2 and Cdk2 kinase activity with no change in Cdk2 and Cdc2 expression.	Genistein	10-19	cyclin dependent kinase 1	Homo sapiens	124-128
10676638-8	2000	Chk1 phosphorylates the dual specificity phosphatase cdc25C on Ser-216, and this may be involved in preventing cdc25 from activating cdc2/cyclinB and initiating mitosis.	Serine	63-66	cyclin dependent kinase 1	Homo sapiens	53-57
10741643-0	2000	Influence of the G2 cell cycle block abrogator pentoxifylline on the expression and subcellular location of cyclin B1 and p34cdc2 in HeLa cervical carcinoma cells.	abrogator	37-46	cyclin dependent kinase 1	Homo sapiens	122-129
10741643-0	2000	Influence of the G2 cell cycle block abrogator pentoxifylline on the expression and subcellular location of cyclin B1 and p34cdc2 in HeLa cervical carcinoma cells.	Pentoxifylline	47-61	cyclin dependent kinase 1	Homo sapiens	122-129
10741643-4	2000	The present study shows that irradiation, and 2 mM pentoxifylline affect the expression of the cyclin-dependent kinase p34cdc2 in HeLa cells.	Pentoxifylline	51-65	cyclin dependent kinase 1	Homo sapiens	119-126
10741643-7	2000	This is also evident from the cyclin B1/p34cdc2 ratios which decline after irradiation and are rapidly restored to control levels upon addition of pentoxifylline.	Pentoxifylline	147-161	cyclin dependent kinase 1	Homo sapiens	40-47
10761703-6	2000	Following genistein treatment of cells, an increased binding of p21 with Cdk2 and Cdc2 paralleled a significant decrease in Cdc2 and Cdk2 kinase activity with no change in Cdk2 and Cdc2 expression.	Genistein	10-19	cyclin dependent kinase 1	Homo sapiens	82-86
10761703-6	2000	Following genistein treatment of cells, an increased binding of p21 with Cdk2 and Cdc2 paralleled a significant decrease in Cdc2 and Cdk2 kinase activity with no change in Cdk2 and Cdc2 expression.	Genistein	10-19	cyclin dependent kinase 1	Homo sapiens	124-128
10761703-9	2000	These data suggest that genistein may exert a strong anticarcinogenic effect, and that this effect possibly involves an induction of p21, which inhibits the threshold kinase activities of Cdks and associated cyclins, leading to a G2/M arrest in the cell cycle progression.	Genistein	24-33	cyclin dependent kinase 1	Homo sapiens	188-192
10644693-5	2000	Furthermore, the hCdc14 phosphatases were found to dephosphorylate p53 specifically at the p34(Cdc2)/clb phosphorylation site (p53-phosphor-Ser(315)).	Serine	140-143	cyclin dependent kinase 1	Homo sapiens	95-99
11341037-6	2000	Methionine restriction led to accumulation of the cyclin-dependent kinase inhibitors p21 and p27, as determined by Western blot analysis, and inhibited the enzymatic activities of the cyclin-dependent kinases CDK2 and cdc2, as determined by an in vitro kinase assay: However, methionine restriction had little or no effect on CDK2 or cdc2 protein levels.	Methionine	0-10	cyclin dependent kinase 1	Homo sapiens	218-222
10648559-3	2000	We demonstrate for the first time that in vivo inhibition of the cdc2- cyclin B kinase activity is sufficient to give rise to okadaic acid-sensitive dephosphorylation of the mitotically phosphorylated forms of components of the rDNA transcription machinery, and consequently to restore rDNA transcription in mitotic cells.	Okadaic Acid	126-138	cyclin dependent kinase 1	Homo sapiens	65-69
10769641-5	2000	The induction of apoptosis by paclitaxel was accompanied by an elevated level of p34cdc2 kinase activity, which was inhibited in the presence of EGF during the post-paclitaxel culture period.	Paclitaxel	30-40	cyclin dependent kinase 1	Homo sapiens	81-88
10656454-8	2000	Genistein tends to cause a dose-dependent induction of G2-M cell cycle arrest and an inhibition of cdc2 kinase activity.	Genistein	0-9	cyclin dependent kinase 1	Homo sapiens	99-103
10769641-5	2000	The induction of apoptosis by paclitaxel was accompanied by an elevated level of p34cdc2 kinase activity, which was inhibited in the presence of EGF during the post-paclitaxel culture period.	Paclitaxel	165-175	cyclin dependent kinase 1	Homo sapiens	81-88
10769641-7	2000	Incubation of paclitaxel-treated MDA-MB-468 cell extracts with EGF-treated MDA-MB-468 cell extract, which exhibited elevation of p34cdc2 activity, inhibited the kinase activity.	Paclitaxel	14-24	cyclin dependent kinase 1	Homo sapiens	129-136
11341037-6	2000	Methionine restriction led to accumulation of the cyclin-dependent kinase inhibitors p21 and p27, as determined by Western blot analysis, and inhibited the enzymatic activities of the cyclin-dependent kinases CDK2 and cdc2, as determined by an in vitro kinase assay: However, methionine restriction had little or no effect on CDK2 or cdc2 protein levels.	Methionine	0-10	cyclin dependent kinase 1	Homo sapiens	334-338
10534572-9	1999	Furthermore, down-regulation of cyclin B and cdk1 was observed in Taxol and Caffeine treated HPAC cells.	Paclitaxel	66-71	cyclin dependent kinase 1	Homo sapiens	45-49
11341037-6	2000	Methionine restriction led to accumulation of the cyclin-dependent kinase inhibitors p21 and p27, as determined by Western blot analysis, and inhibited the enzymatic activities of the cyclin-dependent kinases CDK2 and cdc2, as determined by an in vitro kinase assay: However, methionine restriction had little or no effect on CDK2 or cdc2 protein levels.	Methionine	276-286	cyclin dependent kinase 1	Homo sapiens	218-222
10574948-6	1999	Irradiation led to nuclear accumulation of the inactive tyrosine-phosphorylated form of p34(Cdc2), whereas the active form was seen in the cytoplasm.	Tyrosine	56-64	cyclin dependent kinase 1	Homo sapiens	92-96
10683762-3	1999	The concentrations of cyclin D1 and p21Waf1/Cip1 were dramatically increased, whereas those of cyclin B1 and cdc2 were decreased, by PMA treatment.	Tetradecanoylphorbol Acetate	133-136	cyclin dependent kinase 1	Homo sapiens	109-113
10558879-9	1999	Furthermore, treatment of As(2)O(3) markedly enhanced the binding of p21 with cdc2, and the activity of cdc2 kinase was decreased in a time-dependent manner.	Arsenic Trioxide	26-35	cyclin dependent kinase 1	Homo sapiens	78-82
10558879-9	1999	Furthermore, treatment of As(2)O(3) markedly enhanced the binding of p21 with cdc2, and the activity of cdc2 kinase was decreased in a time-dependent manner.	Arsenic Trioxide	26-35	cyclin dependent kinase 1	Homo sapiens	104-108
10757037-0	1999	Differential regulation of the major cyclin-dependent kinases, cdk2 and cdc2, during cell cycle progression in human lymphocytes exposed to heptachlor.	Heptachlor	140-150	cyclin dependent kinase 1	Homo sapiens	72-76
10656873-11	1999	The cell cycle alterations induced by beta-lapachone were congruous with changes in cell cycle regulatory proteins such as cyclin A, cyclin B1, cdc2, and cyclin D1.	beta-lapachone	38-52	cyclin dependent kinase 1	Homo sapiens	144-148
10564539-7	1999	The reduced activity of p34cdc2 provides a possible mechanism for the accumulation of Caco-2 cells in the G2/M cell cycle compartment following exposure to butyrate.	Butyrates	156-164	cyclin dependent kinase 1	Homo sapiens	24-31
10497277-6	1999	A PLZF-cdc2 interaction was further demonstrated by co-immunoprecipitation and a biotin-streptavidin pull-down assay.	Biotin	81-87	cyclin dependent kinase 1	Homo sapiens	7-11
10496881-6	1999	For its activation at the G2/M border, p34cdc2 needs to be associated with cyclin B and additionally dephosphorylated at Tyr-15 by the specific phosphatase cdc25-C.	Tyrosine	121-124	cyclin dependent kinase 1	Homo sapiens	39-46
10496881-7	1999	Treatment of synchronized cells in S or G2 phase with C. botulinum C2 toxin prevented p34cdc2 protein kinase activation by inhibiting its tyrosine dephosphorylation at the G2/M border.	Tyrosine	138-146	cyclin dependent kinase 1	Homo sapiens	86-93
10516758-4	1999	Potentiation of paclitaxel-induced apoptosis by bryostatin 1 in U937/Bcl-xL cells occurred primarily in the G2M cell population, and was associated with alterations in Bcl-xL gel mobility and a reduction in paclitaxel-mediated stimulation of CDK1 activity.	Paclitaxel	16-26	cyclin dependent kinase 1	Homo sapiens	242-246
10698260-5	1999	However, 200 nM staurosporine increased the expression of cyclin B and cdc2 proteins, suggesting that the cells progressed through the G2/M transition, and increased the expression of MPM2 protein, indicating that the cells entered M phase.	Staurosporine	16-29	cyclin dependent kinase 1	Homo sapiens	71-75
10597228-4	1999	In both cases, CDK1 from arrested cells could be reactivated both in vitro by dephosphorylation by recombinant Cdc25B phosphatase and in vivo by caffeine.	Caffeine	145-153	cyclin dependent kinase 1	Homo sapiens	15-19
10567774-2	1999	In this study we investigated the cellular effects of olomoucine in two human Burkitt"s lymphoma cell lines, WMN (containing wild-type p53) and CA46 (containing mutant p53), and found that in consistency with its ability to block the activity of cyclin E/Cdk2 and cyclin B1/Cdc2 kinases, olomoucine caused cell cycle arrest at both G1/S and G2/S boundaries.	olomoucine	54-64	cyclin dependent kinase 1	Homo sapiens	274-278
10527623-8	1999	Olomoucine and roscovitine, the potent p34(cdc2) and CDK2 inhibitors, effectively blocked CD437-mediated cyclin A- and B-dependent kinase activation and prevented CD437-induced cell death.	olomoucine	0-10	cyclin dependent kinase 1	Homo sapiens	43-47
10527623-8	1999	Olomoucine and roscovitine, the potent p34(cdc2) and CDK2 inhibitors, effectively blocked CD437-mediated cyclin A- and B-dependent kinase activation and prevented CD437-induced cell death.	Roscovitine	15-26	cyclin dependent kinase 1	Homo sapiens	43-47
10502295-0	1999	1,25-dihydroxyvitamin D(3)-induced retardation of the G(2)/M traverse is associated with decreased levels of p34(cdc2) in HL60 cells.	Calcitriol	0-26	cyclin dependent kinase 1	Homo sapiens	113-117
10537037-5	1999	Cyclic AMP strongly inhibited cdk1 and cdk2 expression.	Cyclic AMP	0-10	cyclin dependent kinase 1	Homo sapiens	30-34
10537037-13	1999	We conclude that cyclic AMP inhibits progression of the cell cycle in astrocytes at least by preventing the expression of the regulatory subunits, cyclins D1 and A, and catalytic subunits, cdk1 and cdk2, of cyclin-regulated protein kinases.	Cyclic AMP	17-27	cyclin dependent kinase 1	Homo sapiens	189-193
10564539-0	1999	Butyrate-induced G2/M block in Caco-2 colon cancer cells is associated with decreased p34cdc2 activity.	Butyrates	0-8	cyclin dependent kinase 1	Homo sapiens	86-93
10564539-6	1999	Despite this decrease in activity, the inhibitory tyrosine phosphorylation of p34cdc2 was decreased, suggesting that other factors are responsible for the decreased kinase activity.	Tyrosine	50-58	cyclin dependent kinase 1	Homo sapiens	78-85
10493943-0	1999	2-methoxyestradiol-induced growth suppression and lethality in estrogen-responsive MCF-7 cells may be mediated by down regulation of p34cdc2 and cyclin B1 expression.	2-Methoxyestradiol	0-18	cyclin dependent kinase 1	Homo sapiens	133-140
10493943-9	1999	Further, anti-estrogenic effects of 2-ME in these cells can be accounted for by its activation of apoptotic functions, which are correlated with reductions in expression of p34cdc2 and cyclin B1 genes.	2-Methoxyestradiol	36-40	cyclin dependent kinase 1	Homo sapiens	173-180
10632573-4	1999	GA treatment down-regulated the expression of cyclin B1 and inhibited phosphorylation of Cdc2 protein, both key regulatory proteins at the G2/M boundary.	geldanamycin	0-2	cyclin dependent kinase 1	Homo sapiens	89-93
10632573-5	1999	GA also markedly inhibited the Cdc2 kinase activity, which may be in part a result of up-regulation of p27KIP1 by GA.	geldanamycin	0-2	cyclin dependent kinase 1	Homo sapiens	31-35
10563371-0	1999	Exploration of the effect of sterically demanding 3"-amido substitution of 3"-deoxyadenosines towards inhibition of cyclin-dependent kinase 1.	3"-amido	50-58	cyclin dependent kinase 1	Homo sapiens	116-141
10563371-0	1999	Exploration of the effect of sterically demanding 3"-amido substitution of 3"-deoxyadenosines towards inhibition of cyclin-dependent kinase 1.	cordycepin	75-93	cyclin dependent kinase 1	Homo sapiens	116-141
10510942-4	1999	Paclitaxel-induced G2/M cell cycle arrest correlated with cdc2 kinase activity and bcl-2 phosphorylation.	Paclitaxel	0-10	cyclin dependent kinase 1	Homo sapiens	58-62
10495356-3	1999	Intensive screening has lead to the recent identification of a series of chemical inhibitors of CDKs: olomoucine, roscovitine, purvalanol, CVT-313, flavopiridol, g-butyrolactone, indirubins, paullones and staurosporine.	olomoucine	102-112	cyclin dependent kinase 1	Homo sapiens	96-100
10495356-3	1999	Intensive screening has lead to the recent identification of a series of chemical inhibitors of CDKs: olomoucine, roscovitine, purvalanol, CVT-313, flavopiridol, g-butyrolactone, indirubins, paullones and staurosporine.	indirubin	179-189	cyclin dependent kinase 1	Homo sapiens	96-100
10495356-3	1999	Intensive screening has lead to the recent identification of a series of chemical inhibitors of CDKs: olomoucine, roscovitine, purvalanol, CVT-313, flavopiridol, g-butyrolactone, indirubins, paullones and staurosporine.	paullone	191-200	cyclin dependent kinase 1	Homo sapiens	96-100
10495356-3	1999	Intensive screening has lead to the recent identification of a series of chemical inhibitors of CDKs: olomoucine, roscovitine, purvalanol, CVT-313, flavopiridol, g-butyrolactone, indirubins, paullones and staurosporine.	Staurosporine	205-218	cyclin dependent kinase 1	Homo sapiens	96-100
10658532-1	1999	Our early reports have indicated that vitamin K3 (VK3) exerts antitumour activity by inhibiting Cdk1 activity and overexpressing the c-myc gene to induce an apoptotic cell death.	Vitamin K 3	38-48	cyclin dependent kinase 1	Homo sapiens	96-100
10454534-2	1999	Comparison between normal human foreskin fibroblasts (HFFs) and HFFs in which p53 was eliminated by transduction with human papillomavirus type 16 E6 showed that treatment with adriamycin initiated arrest in G(2) with active cyclin B/CDC2 kinase, regardless of p53 status.	Doxorubicin	177-187	cyclin dependent kinase 1	Homo sapiens	234-238
10428760-0	1999	Cholesterol starvation decreases p34(cdc2) kinase activity and arrests the cell cycle at G2.	Cholesterol	0-11	cyclin dependent kinase 1	Homo sapiens	37-41
10428760-11	1999	Caffeine, which abrogates the G2 checkpoint by preventing p34(cdc2) phosphorylation, reduced the accumulation in G2 when added to cultures containing cells on transit to G2, but was ineffective in cells arrested at G2 by sustained cholesterol starvation.	Caffeine	0-8	cyclin dependent kinase 1	Homo sapiens	62-66
10428760-12	1999	Cells arrested in G2, however, were still viable and responded to cholesterol provision by activating p34(cdc2) and resuming the cell cycle.	Cholesterol	66-77	cyclin dependent kinase 1	Homo sapiens	106-110
10428760-13	1999	We conclude that in both lymphoblastoid and promyelocytic cells, cholesterol availability governs the G2 traversal, probably by affecting p34(cdc2) activity.	Cholesterol	65-76	cyclin dependent kinase 1	Homo sapiens	142-146
10534572-9	1999	Furthermore, down-regulation of cyclin B and cdk1 was observed in Taxol and Caffeine treated HPAC cells.	Caffeine	76-84	cyclin dependent kinase 1	Homo sapiens	45-49
10534572-9	1999	Furthermore, down-regulation of cyclin B and cdk1 was observed in Taxol and Caffeine treated HPAC cells.	hpac	93-97	cyclin dependent kinase 1	Homo sapiens	45-49
10534572-13	1999	The up-regulation of p21WAF1 and down-regulation of cyclin B and cdk1 suggest their possible roles in G2/M cell cycle arrest caused by both Taxol and Caffeine as reported earlier.	Paclitaxel	140-145	cyclin dependent kinase 1	Homo sapiens	65-69
10534572-13	1999	The up-regulation of p21WAF1 and down-regulation of cyclin B and cdk1 suggest their possible roles in G2/M cell cycle arrest caused by both Taxol and Caffeine as reported earlier.	Caffeine	150-158	cyclin dependent kinase 1	Homo sapiens	65-69
10465404-1	1999	Novel C-2, C-6, N-9 trisubstituted purines derived from the olomoucine/roscovitine lead structure were synthesized and evaluated for their ability to inhibit starfish oocyte CDK1/cyclin B, neuronal CDK5/p35 and erk1 kinases in purified extracts.	trisubstituted	20-34	cyclin dependent kinase 1	Homo sapiens	174-178
10425100-0	1999	Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity.	paullone	0-9	cyclin dependent kinase 1	Homo sapiens	84-88
10425100-10	1999	Substitutions in other positions or the replacement of the lactam moiety led to decreased CDK1 inhibition.	Lactams	59-65	cyclin dependent kinase 1	Homo sapiens	90-94
10425100-12	1999	The 9-nitro-7,12-dihydroindolo[3, 2-d][1]benzazepin-6(5H)-one (4j, named alsterpaullone) showed a high CDK1/cyclin B inhibitory activity (IC(50) = 0.035 microM) and exceeded the in vitro antitumor potency of the other paullones by 1 order of magnitude (log GI(50) mean graph midpoint = -6.4 M).	alsterpaullone	4-61	cyclin dependent kinase 1	Homo sapiens	103-107
10425100-12	1999	The 9-nitro-7,12-dihydroindolo[3, 2-d][1]benzazepin-6(5H)-one (4j, named alsterpaullone) showed a high CDK1/cyclin B inhibitory activity (IC(50) = 0.035 microM) and exceeded the in vitro antitumor potency of the other paullones by 1 order of magnitude (log GI(50) mean graph midpoint = -6.4 M).	alsterpaullone	73-87	cyclin dependent kinase 1	Homo sapiens	103-107
10393926-3	1999	We used digitonin-permeabilized human cells to analyze the mechanism by which cyclin B1-Cdc2 is imported into the nucleus.	Digitonin	8-17	cyclin dependent kinase 1	Homo sapiens	88-92
10465404-1	1999	Novel C-2, C-6, N-9 trisubstituted purines derived from the olomoucine/roscovitine lead structure were synthesized and evaluated for their ability to inhibit starfish oocyte CDK1/cyclin B, neuronal CDK5/p35 and erk1 kinases in purified extracts.	Purines	35-42	cyclin dependent kinase 1	Homo sapiens	174-178
10465404-1	1999	Novel C-2, C-6, N-9 trisubstituted purines derived from the olomoucine/roscovitine lead structure were synthesized and evaluated for their ability to inhibit starfish oocyte CDK1/cyclin B, neuronal CDK5/p35 and erk1 kinases in purified extracts.	olomoucine	60-70	cyclin dependent kinase 1	Homo sapiens	174-178
10465404-3	1999	Optimal inhibitory activity against CDK5, CDK1 and CDK2, with IC50 values of 0.16, 0.45 and 0.65 microM, respectively, was obtained with compound 21 containing a (2R)-pyrrolidin-2-yl-methanol substituent at the C-2 and a 3-iodobenzylamino group at the C-6 of the purine.	(2r)-pyrrolidin-2-yl-methanol	162-191	cyclin dependent kinase 1	Homo sapiens	42-46
10373560-1	1999	The Myt1 protein kinase functions to negatively regulate Cdc2-cyclin B complexes by phosphorylating Cdc2 on threonine 14 and tyrosine 15.	Threonine	108-117	cyclin dependent kinase 1	Homo sapiens	57-61
10373560-1	1999	The Myt1 protein kinase functions to negatively regulate Cdc2-cyclin B complexes by phosphorylating Cdc2 on threonine 14 and tyrosine 15.	Threonine	108-117	cyclin dependent kinase 1	Homo sapiens	100-104
10373560-1	1999	The Myt1 protein kinase functions to negatively regulate Cdc2-cyclin B complexes by phosphorylating Cdc2 on threonine 14 and tyrosine 15.	Tyrosine	125-133	cyclin dependent kinase 1	Homo sapiens	57-61
10363974-1	1999	Analysis of the National Cancer Institute Human Tumor Cell Line Anti-Cancer Drug Screen data using the COMPARE algorithm to detect similarities in the pattern of compound action to flavopiridol, a known inhibitor of cyclin-dependent kinases (CDKs), has suggested several possible novel CDK inhibitors.	alvocidib	181-193	cyclin dependent kinase 1	Homo sapiens	242-246
10363974-1	1999	Analysis of the National Cancer Institute Human Tumor Cell Line Anti-Cancer Drug Screen data using the COMPARE algorithm to detect similarities in the pattern of compound action to flavopiridol, a known inhibitor of cyclin-dependent kinases (CDKs), has suggested several possible novel CDK inhibitors.	alvocidib	181-193	cyclin dependent kinase 1	Homo sapiens	242-245
10363974-2	1999	9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one, NSC-664704 (kenpaullone), is reported here to be a potent inhibitor of CDK1/cyclin B (IC50, 0.4 microM).	kenpaullone	0-57	cyclin dependent kinase 1	Homo sapiens	130-134
10363974-2	1999	9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one, NSC-664704 (kenpaullone), is reported here to be a potent inhibitor of CDK1/cyclin B (IC50, 0.4 microM).	kenpaullone	71-82	cyclin dependent kinase 1	Homo sapiens	130-134
10363974-6	1999	Analogues of kenpaullone, in particular 10-bromopaullone (NSC-672234), also inhibited various protein kinases including CDKs.	kenpaullone	13-24	cyclin dependent kinase 1	Homo sapiens	120-124
10363974-6	1999	Analogues of kenpaullone, in particular 10-bromopaullone (NSC-672234), also inhibited various protein kinases including CDKs.	NSC672234	40-56	cyclin dependent kinase 1	Homo sapiens	120-124
10363974-8	1999	Kenpaullone represents a novel chemotype for compounds that preferentially inhibit CDKs.	kenpaullone	0-11	cyclin dependent kinase 1	Homo sapiens	83-87
10094816-6	1999	Olomoucine, a potent p34(cdc2) and Cdk2 inhibitor, effectively blocked RA-mediated p34(cdc2) kinase activation and prevented RA-induced apoptosis.	olomoucine	0-10	cyclin dependent kinase 1	Homo sapiens	25-29
10323868-3	1999	p27 can be phosphorylated on threonine 187 by Cdks, and cyclin E/Cdk2 overexpression can stimulate the degradation of wild-type p27, but not of a threonine 187-to-alanine p27 mutant [p27(T187A)].	Threonine	29-38	cyclin dependent kinase 1	Homo sapiens	46-50
10094816-0	1999	Induction of p21(CIP1/Waf1) and activation of p34(cdc2) involved in retinoic acid-induced apoptosis in human hepatoma Hep3B cells.	Tretinoin	68-81	cyclin dependent kinase 1	Homo sapiens	50-54
10094816-3	1999	This RA-induced apoptosis was accompanied by p53-independent up-regulation of endogenous p21(CIPI/Waf1) and Bax proteins, as well as activation of p34(cdc2) kinase, and increase of Rb2 protein level and phosphorylation pattern.	Tretinoin	5-7	cyclin dependent kinase 1	Homo sapiens	151-155
10092502-7	1999	However, when interphase cyclosome was first incubated with protein kinase Cdk1/cyclin B without Suc1, the subsequent addition of Suc1 caused a rapid burst of cyclosome activation and the lag was completely abolished.	suc1	130-134	cyclin dependent kinase 1	Homo sapiens	75-79
10098730-0	1999	Butyrate augments interferon-alpha-induced S phase accumulation and persistent tyrosine phosphorylation of cdc2 in K562 cells.	Butyrates	0-8	cyclin dependent kinase 1	Homo sapiens	107-111
10098730-0	1999	Butyrate augments interferon-alpha-induced S phase accumulation and persistent tyrosine phosphorylation of cdc2 in K562 cells.	Tyrosine	79-87	cyclin dependent kinase 1	Homo sapiens	107-111
10098730-6	1999	The ability of leukaemic cells to exhibit the S phase accumulation after stimulation by IFN-alpha plus sodium butyrate correlated well with persistent tyrosine phosphorylation of cdc2, whereas treatment with IFN-gamma plus sodium butyrate did not affect its phosphorylation levels.	Butyric Acid	103-118	cyclin dependent kinase 1	Homo sapiens	179-183
9925771-1	1999	EX984115, "Cdc2-independent induction of premature mitosis by okadaic acid in HeLa Cells," by S. Ghosh, N. Paweletz, and D. Schroeter, pages 1-9	Okadaic Acid	62-74	cyclin dependent kinase 1	Homo sapiens	11-15
9922449-4	1999	To elucidate the molecular mechanisms responsible for Cdk/cyclin transport, we examined nuclear import of fluorescent Cdk2/cyclin E and Cdc2/cyclin B1 complexes in digitonin-permeabilized mammalian cells and also examined potential physical interactions between these Cdks, cyclins, and soluble import factors.	Digitonin	164-173	cyclin dependent kinase 1	Homo sapiens	136-140
9927053-7	1999	The growth arrest of keratinocytes induced by TSA or butyrate was accompanied by a reduction in the mRNA levels for proliferation gene cdk1 and an induction of the mRNA for the differentiation-specific transglutaminase type I gene (TG1).	trichostatin A	46-49	cyclin dependent kinase 1	Homo sapiens	135-139
9927053-7	1999	The growth arrest of keratinocytes induced by TSA or butyrate was accompanied by a reduction in the mRNA levels for proliferation gene cdk1 and an induction of the mRNA for the differentiation-specific transglutaminase type I gene (TG1).	Butyrates	53-61	cyclin dependent kinase 1	Homo sapiens	135-139
9927053-8	1999	In contrast, the squamous carcinoma cells had decreased cdk1 and TG1 mRNA in response to TSA or butyrate.	trichostatin A	89-92	cyclin dependent kinase 1	Homo sapiens	56-60
9927053-8	1999	In contrast, the squamous carcinoma cells had decreased cdk1 and TG1 mRNA in response to TSA or butyrate.	Butyrates	96-104	cyclin dependent kinase 1	Homo sapiens	56-60
9990288-0	1999	Ribonucleotide reductase R2 protein is phosphorylated at serine-20 by P34cdc2 kinase.	Serine	57-63	cyclin dependent kinase 1	Homo sapiens	70-77
9990288-3	1999	A sequence in the R2 protein at serine-20 matches a consensus sequence for p34cdc2 and CDK2 kinases.	Serine	32-38	cyclin dependent kinase 1	Homo sapiens	75-82
9990288-4	1999	We tested the hypothesis that the serine-20 residue was the major p34cdc2 kinase site of phosphorylation.	Serine	34-40	cyclin dependent kinase 1	Homo sapiens	66-73
9990288-9	1999	Wild type R2 and threonine-substituted R2 proteins (R2-Thr) were phosphorylated by p34cdc2 kinase, whereas under the same experimental conditions, R2-Asp and R2-Ala phosphorylation was not detected.	Threonine	55-58	cyclin dependent kinase 1	Homo sapiens	83-90
9990288-12	1999	In total, these results firmly establish that a major p34cdc2 phosphorylation site on the ribonucleotide reductase R2 protein occurs near the N-terminal end at serine-20, which is found within the sequence Ser-Pro-Leu-Lys-Arg-Leu.	Serine	160-166	cyclin dependent kinase 1	Homo sapiens	54-61
9990288-12	1999	In total, these results firmly establish that a major p34cdc2 phosphorylation site on the ribonucleotide reductase R2 protein occurs near the N-terminal end at serine-20, which is found within the sequence Ser-Pro-Leu-Lys-Arg-Leu.	Serine	206-209	cyclin dependent kinase 1	Homo sapiens	54-61
9990288-12	1999	In total, these results firmly establish that a major p34cdc2 phosphorylation site on the ribonucleotide reductase R2 protein occurs near the N-terminal end at serine-20, which is found within the sequence Ser-Pro-Leu-Lys-Arg-Leu.	Arginine	222-225	cyclin dependent kinase 1	Homo sapiens	54-61
9990288-12	1999	In total, these results firmly establish that a major p34cdc2 phosphorylation site on the ribonucleotide reductase R2 protein occurs near the N-terminal end at serine-20, which is found within the sequence Ser-Pro-Leu-Lys-Arg-Leu.	Leucine	214-217	cyclin dependent kinase 1	Homo sapiens	54-61
9926943-5	1999	TGFbeta treatment also caused threonine phosphorylation of Cdc2 in the TGFbeta RII-cyclin B2-Cdc2 complex in THP1 cells, in parallel with down regulation of Cdc2 function as measured by histone H1 kinase activity.	Threonine	30-39	cyclin dependent kinase 1	Homo sapiens	59-63
9926943-5	1999	TGFbeta treatment also caused threonine phosphorylation of Cdc2 in the TGFbeta RII-cyclin B2-Cdc2 complex in THP1 cells, in parallel with down regulation of Cdc2 function as measured by histone H1 kinase activity.	Threonine	30-39	cyclin dependent kinase 1	Homo sapiens	93-97
9926943-5	1999	TGFbeta treatment also caused threonine phosphorylation of Cdc2 in the TGFbeta RII-cyclin B2-Cdc2 complex in THP1 cells, in parallel with down regulation of Cdc2 function as measured by histone H1 kinase activity.	Threonine	30-39	cyclin dependent kinase 1	Homo sapiens	93-97
10500810-6	1999	Olomoucine (OC), flavopiridol (FP), butyrolactone I (BL) and their derivatives selectively inhibit CDKs and thus constrain tumor cell proliferation under in vitro and/or in vivo conditions.	olomoucine	0-10	cyclin dependent kinase 1	Homo sapiens	99-103
10500810-6	1999	Olomoucine (OC), flavopiridol (FP), butyrolactone I (BL) and their derivatives selectively inhibit CDKs and thus constrain tumor cell proliferation under in vitro and/or in vivo conditions.	olomoucine	12-14	cyclin dependent kinase 1	Homo sapiens	99-103
10500810-6	1999	Olomoucine (OC), flavopiridol (FP), butyrolactone I (BL) and their derivatives selectively inhibit CDKs and thus constrain tumor cell proliferation under in vitro and/or in vivo conditions.	alvocidib	17-29	cyclin dependent kinase 1	Homo sapiens	99-103
10500810-6	1999	Olomoucine (OC), flavopiridol (FP), butyrolactone I (BL) and their derivatives selectively inhibit CDKs and thus constrain tumor cell proliferation under in vitro and/or in vivo conditions.	4-Butyrolactone	36-49	cyclin dependent kinase 1	Homo sapiens	99-103
9888468-4	1999	At 24 h after IHB exposure, the majority of cells blocked in G2M were in prophase as assessed by morphological analysis and by the fact that they expressed high levels of cyclin A/cdc2 and cyclin B1/cdc2.	isohomohalichondrin B	14-17	cyclin dependent kinase 1	Homo sapiens	180-184
9888468-4	1999	At 24 h after IHB exposure, the majority of cells blocked in G2M were in prophase as assessed by morphological analysis and by the fact that they expressed high levels of cyclin A/cdc2 and cyclin B1/cdc2.	isohomohalichondrin B	14-17	cyclin dependent kinase 1	Homo sapiens	199-203
10665481-2	1999	Flavopiridol (HMR 1275, L86-8275), a flavonoid derived from an indigenous plant from India, demonstrated potent and specific in vitro inhibition of all cdks tested (cdks 1, 2, 4 and 7) with clear block in cell cycle progression at the G1/S and G2/M boundaries.	alvocidib	0-12	cyclin dependent kinase 1	Homo sapiens	165-183
16127615-4	1999	There is a lot of interest in targeting cyclin-dependent kinases (cdk): flavopiridol (Hoechst AG), a broad-spectrum inhibitor of cdk1, cdk2 and cdk4 is now entering phase II trials.	alvocidib	72-84	cyclin dependent kinase 1	Homo sapiens	66-69
16127615-4	1999	There is a lot of interest in targeting cyclin-dependent kinases (cdk): flavopiridol (Hoechst AG), a broad-spectrum inhibitor of cdk1, cdk2 and cdk4 is now entering phase II trials.	alvocidib	72-84	cyclin dependent kinase 1	Homo sapiens	129-133
16127615-4	1999	There is a lot of interest in targeting cyclin-dependent kinases (cdk): flavopiridol (Hoechst AG), a broad-spectrum inhibitor of cdk1, cdk2 and cdk4 is now entering phase II trials.	hoechst ag	86-96	cyclin dependent kinase 1	Homo sapiens	66-69
16127615-4	1999	There is a lot of interest in targeting cyclin-dependent kinases (cdk): flavopiridol (Hoechst AG), a broad-spectrum inhibitor of cdk1, cdk2 and cdk4 is now entering phase II trials.	hoechst ag	86-96	cyclin dependent kinase 1	Homo sapiens	129-133
10360785-4	1999	The results from these experiments demonstrate that concomitant exposure of HL60 cells to caffeine (2 mM) during irradiation inhibited radiation-induced tyrosine 15 phosphorylation of the G2/M-phase transition checkpoint protein CDC2/p34 kinase and reduced G2/M-phase arrest by 40-46% compared to cells irradiated without caffeine.	Caffeine	90-98	cyclin dependent kinase 1	Homo sapiens	229-233
10360785-4	1999	The results from these experiments demonstrate that concomitant exposure of HL60 cells to caffeine (2 mM) during irradiation inhibited radiation-induced tyrosine 15 phosphorylation of the G2/M-phase transition checkpoint protein CDC2/p34 kinase and reduced G2/M-phase arrest by 40-46% compared to cells irradiated without caffeine.	Tyrosine	153-161	cyclin dependent kinase 1	Homo sapiens	229-233
10360785-4	1999	The results from these experiments demonstrate that concomitant exposure of HL60 cells to caffeine (2 mM) during irradiation inhibited radiation-induced tyrosine 15 phosphorylation of the G2/M-phase transition checkpoint protein CDC2/p34 kinase and reduced G2/M-phase arrest by 40-46% compared to cells irradiated without caffeine.	Caffeine	322-330	cyclin dependent kinase 1	Homo sapiens	229-233
10319729-7	1999	Reduced proliferation after combined irradiation and PD98059 treatment in both cell types correlated with reduced Cdc2 activity and arrest in G2/M phase of the cell cycle.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	53-60	cyclin dependent kinase 1	Homo sapiens	114-118
10347813-2	1999	We examined the effects of TNF (1-100 ng/ml) and butyrolactone I (100 microM), a specific inhibitor of cyclin-dependent kinases (CDK) with high selectivity for CDK-1 and CDK-2, on three different cancer cell lines: WEHI, L929 and HeLa S3.	4-Butyrolactone	49-62	cyclin dependent kinase 1	Homo sapiens	129-132
10347813-5	1999	In vitro phosphorylation assays for exogenous histone H1 and endogenous retinoblastoma protein (pRb) in the total cell lysates showed that treatment with both TNF and butyrolactone inhibited the histone H1 kinase (WEHI, L929 and HeLa) and pRb kinase (WEHI) activities of CDKs, as compared with the controls.	4-Butyrolactone	167-180	cyclin dependent kinase 1	Homo sapiens	271-275
10368682-0	1999	Use of CDC2 from etoposide-treated cells as substrate to assay CDC25 phosphatase activity.	Etoposide	17-26	cyclin dependent kinase 1	Homo sapiens	7-11
10368682-2	1999	In response to Etoposide (VP-16) induced DNA damage, cells undergo a G2-phase arrest resulting in the accumulation of inactive CDK1 (CDC2) kinase complexes.	Etoposide	15-24	cyclin dependent kinase 1	Homo sapiens	127-131
10368682-2	1999	In response to Etoposide (VP-16) induced DNA damage, cells undergo a G2-phase arrest resulting in the accumulation of inactive CDK1 (CDC2) kinase complexes.	Etoposide	15-24	cyclin dependent kinase 1	Homo sapiens	133-137
10368682-3	1999	Here we report that upon Etoposide treatment CDC2 is phosphorylated on tyrosine 15 and is dephosphorylated and activated in vitro by recombinant CDC25 phosphatase.	Etoposide	25-34	cyclin dependent kinase 1	Homo sapiens	45-49
10368682-3	1999	Here we report that upon Etoposide treatment CDC2 is phosphorylated on tyrosine 15 and is dephosphorylated and activated in vitro by recombinant CDC25 phosphatase.	Tyrosine	71-79	cyclin dependent kinase 1	Homo sapiens	45-49
10368682-4	1999	We also show that inactive CDC2 kinase from Etoposide-treated cells can be used as a substrate in a sensitive two-step assay of CDC25 phosphatase.	Etoposide	44-53	cyclin dependent kinase 1	Homo sapiens	27-31
10098730-6	1999	The ability of leukaemic cells to exhibit the S phase accumulation after stimulation by IFN-alpha plus sodium butyrate correlated well with persistent tyrosine phosphorylation of cdc2, whereas treatment with IFN-gamma plus sodium butyrate did not affect its phosphorylation levels.	Tyrosine	151-159	cyclin dependent kinase 1	Homo sapiens	179-183
10098730-7	1999	Considering that dephosphorylation of cdc2 leads to entry to the M phase, the persistent tyrosine phosphorylation of cdc2 may be associated with the S phase accumulation induced by IFN-alpha and sodium butyrate.	Tyrosine	89-97	cyclin dependent kinase 1	Homo sapiens	38-42
10098730-7	1999	Considering that dephosphorylation of cdc2 leads to entry to the M phase, the persistent tyrosine phosphorylation of cdc2 may be associated with the S phase accumulation induced by IFN-alpha and sodium butyrate.	Tyrosine	89-97	cyclin dependent kinase 1	Homo sapiens	117-121
10098730-7	1999	Considering that dephosphorylation of cdc2 leads to entry to the M phase, the persistent tyrosine phosphorylation of cdc2 may be associated with the S phase accumulation induced by IFN-alpha and sodium butyrate.	Butyric Acid	195-210	cyclin dependent kinase 1	Homo sapiens	38-42
10098730-7	1999	Considering that dephosphorylation of cdc2 leads to entry to the M phase, the persistent tyrosine phosphorylation of cdc2 may be associated with the S phase accumulation induced by IFN-alpha and sodium butyrate.	Butyric Acid	195-210	cyclin dependent kinase 1	Homo sapiens	117-121
10037143-7	1999	Furthermore, we found that after PMA treatment p21 was able to associate with the active Tyr-15 dephosphorylated form of cdc2, but this complex was devoid of kinase activity indicating that p21 may play a role in inhibition of cdc2 induced by PMA.	Tyrosine	89-92	cyclin dependent kinase 1	Homo sapiens	121-125
9990463-0	1999	2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors.	2,6,9-trisubstituted purines	0-28	cyclin dependent kinase 1	Homo sapiens	79-83
9990463-1	1999	Novel 2,6,9-substituted purine derivatives represent a class of potent and selective inhibitors of CDK1/cyclinB.	2,6,9-substituted purine	6-30	cyclin dependent kinase 1	Homo sapiens	99-103
10194549-3	1999	The nocodazole-synchronized cells progressed from M to G1 phase in the absence of the drug, which was accompanied by a decrease of cyclin B1 protein expression, disappearance of the complex formation of CDC2 with cyclin B1 and reduction of the kinase activity.	Nocodazole	4-14	cyclin dependent kinase 1	Homo sapiens	203-207
10194549-7	1999	In addition, augmentation of CDC2 protein tyrosine phosphorylation was induced only when the cells were treated with STP.	Tyrosine	42-50	cyclin dependent kinase 1	Homo sapiens	29-33
10094816-6	1999	Olomoucine, a potent p34(cdc2) and Cdk2 inhibitor, effectively blocked RA-mediated p34(cdc2) kinase activation and prevented RA-induced apoptosis.	olomoucine	0-10	cyclin dependent kinase 1	Homo sapiens	87-91
10094816-6	1999	Olomoucine, a potent p34(cdc2) and Cdk2 inhibitor, effectively blocked RA-mediated p34(cdc2) kinase activation and prevented RA-induced apoptosis.	Tretinoin	71-73	cyclin dependent kinase 1	Homo sapiens	25-29
10094816-6	1999	Olomoucine, a potent p34(cdc2) and Cdk2 inhibitor, effectively blocked RA-mediated p34(cdc2) kinase activation and prevented RA-induced apoptosis.	Tretinoin	71-73	cyclin dependent kinase 1	Homo sapiens	87-91
10094816-7	1999	Furthermore, antisense oligonucleotide complementary to p21(CIP2/Waf1) and p34(cdc2) mRNA significantly rescued RA-induced apoptosis.	Oligonucleotides	23-38	cyclin dependent kinase 1	Homo sapiens	79-83
10094816-7	1999	Furthermore, antisense oligonucleotide complementary to p21(CIP2/Waf1) and p34(cdc2) mRNA significantly rescued RA-induced apoptosis.	Tretinoin	112-114	cyclin dependent kinase 1	Homo sapiens	79-83
10094816-11	1999	These findings suggest that inappropriate regulation of the cell cycle regulators p21(CIP2/Waf1) and p34(cdc2) is coupled with induction of Bax and involved in cell death with apoptosis when Hep3B cells are exposed to RA.	Tretinoin	218-220	cyclin dependent kinase 1	Homo sapiens	105-109
10049063-5	1999	The cell cycle modifications in these cell lines correlated with the increase in radiation-induced p34Cdc2 kinase activity by caffeine.	Caffeine	126-134	cyclin dependent kinase 1	Homo sapiens	99-106
15539246-0	1999	R-(+)-perillyl alcohol-induced cell cycle changes, altered actin cytoskeleton, and decreased ras and p34(cdc2) expression in colonic adenocarcinoma SW480 cells.	r-(+)-perillyl alcohol	0-22	cyclin dependent kinase 1	Homo sapiens	105-109
9802881-2	1998	Flavopiridol inhibits most cyclin-dependent kinases (cdks) and displays unique anticancer properties.	alvocidib	0-12	cyclin dependent kinase 1	Homo sapiens	53-57
9820826-4	1998	In vitro the hCAF-1/BTG1 complex formation was dependent on the phosphorylation of a putative p34cdc2 kinase site on BTG1 (Ser-159).	Serine	123-126	cyclin dependent kinase 1	Homo sapiens	94-101
9844922-3	1998	Taxol-induced G2/M transition is mediated by p34(cdc-2) (CDK1) which, if prematurely activated, may also trigger apoptosis.	Paclitaxel	0-5	cyclin dependent kinase 1	Homo sapiens	49-54
9844922-3	1998	Taxol-induced G2/M transition is mediated by p34(cdc-2) (CDK1) which, if prematurely activated, may also trigger apoptosis.	Paclitaxel	0-5	cyclin dependent kinase 1	Homo sapiens	57-61
9844922-6	1998	In addition, the in vitro histone H1 kinase activity of immunoprecipitated CDK1 and its tyrosine phosphorylation status (by anti-phosphotyrosine immunoblot analysis) were determined.	Tyrosine	88-96	cyclin dependent kinase 1	Homo sapiens	75-79
9844922-7	1998	Data presented here show that, while Taxol-induced peak CDK1 kinase activity occurs earlier in HL-60/neo cells, there are no significant differences in cyclin B1 accumulation, tyrosine dephosphorylation of CDK1, and mitotic arrest of Taxol-treated HL-60/neo vs HL-60/Bcl-xL cells.	Paclitaxel	37-42	cyclin dependent kinase 1	Homo sapiens	56-60
9844922-8	1998	Taxol-induced CDK1 activation and mitosis preceded the cytosolic accumulation (approximately six-fold) of cyt c.	Paclitaxel	0-5	cyclin dependent kinase 1	Homo sapiens	14-18
9820491-6	1998	In this age group, only a minimal cdk1 activity could be immunoprecipitated from cells sorted in G2/M after nocodazole block.	Nocodazole	108-118	cyclin dependent kinase 1	Homo sapiens	34-38
9820491-7	1998	The decrease in cdk1 activity observed in T lymphocytes from aged donors could be accounted for by at least three mechanisms: 1) a failure of these cells to express a sufficient amount of cdk1, 2) a reduced level of the associated cyclin B1, and 3) an incomplete dephosphorylation of the kinase on tyrosine.	Tyrosine	298-306	cyclin dependent kinase 1	Homo sapiens	16-20
9852131-9	1998	Our results suggest that at the onset of mitosis, CDK1 phosphorylates RIIalpha, and this may alter its subcellular localization.	riialpha	70-78	cyclin dependent kinase 1	Homo sapiens	50-54
9844922-0	1998	Temporal relationship of CDK1 activation and mitotic arrest to cytosolic accumulation of cytochrome C and caspase-3 activity during Taxol-induced apoptosis of human AML HL-60 cells.	Paclitaxel	132-137	cyclin dependent kinase 1	Homo sapiens	25-29
9802881-4	1998	Exposure of HNSCC cells to flavopiridol diminished cdc2 and cdk2 activity and potently inhibited cell proliferation (IC50 43-83 nM), which was concomitant with the appearance of cells with a sub-G1 DNA content.	alvocidib	27-39	cyclin dependent kinase 1	Homo sapiens	51-55
9802893-3	1998	These bimA1(APC3)-induced cell cycle oscillations require active NIMA, because a nimA5 + bimA1(APC3) double mutant arrests in a mitotic state with very high p34(cdc2) H1 kinase activity.	nima	65-69	cyclin dependent kinase 1	Homo sapiens	161-165
9683802-5	1998	A co-precipitation study showed that in cells treated with gamma-LA there was an increase in the binding of these inhibitors with CDK4, CDC2, and cyclin E. Flow cytometry study indicated an inhibition of cell cycle progression by gamma-LA (G0/G1 -45.4%, S - 34.6%, G2+M - 20.0% in control, and 70.5%, 21.0%, and 8.5%, respectively, in gamma-LA treated cells).	gamma-Linolenic Acid	59-67	cyclin dependent kinase 1	Homo sapiens	136-140
9770514-5	1998	The majority of cdc2, however, was tyrosine-phosphorylated and therefore enzymatically inactive.	Tyrosine	35-43	cyclin dependent kinase 1	Homo sapiens	16-20
9844631-0	1998	Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase.	Paclitaxel	31-36	cyclin dependent kinase 1	Homo sapiens	98-105
9844631-3	1998	Taxol activates p34Cdc2 kinase in MDA-MB-435 breast cancer cells, leading to cell cycle arrest at the G2/M phase and, subsequently, apoptosis.	Paclitaxel	0-5	cyclin dependent kinase 1	Homo sapiens	16-23
9844631-4	1998	A chemical inhibitor of p34Cdc2 and a dominant-negative mutant of p34Cdc2 blocked Taxol-induced apoptosis in these cells.	Paclitaxel	82-87	cyclin dependent kinase 1	Homo sapiens	24-31
9844631-4	1998	A chemical inhibitor of p34Cdc2 and a dominant-negative mutant of p34Cdc2 blocked Taxol-induced apoptosis in these cells.	Paclitaxel	82-87	cyclin dependent kinase 1	Homo sapiens	66-73
9844631-5	1998	Overexpression of p185ErbB2 in MDA-MB-435 cells by transfection transcriptionally upregulates p21Cip1, which associates with p34Cdc2, inhibits Taxol-mediated p34Cdc2 activation, delays cell entrance to G2/M phase, and thereby inhibits Taxol-induced apoptosis.	Paclitaxel	143-148	cyclin dependent kinase 1	Homo sapiens	158-165
9835643-3	1998	This article discusses how Cdc2 kinase is activated in response to the hormone 1-methyladenine at the release from the meiotic prophase arrest, and how MAP kinase is involved in the arrest at the female pronucleus stage.	1-methyladenine	79-94	cyclin dependent kinase 1	Homo sapiens	27-31
9683802-5	1998	A co-precipitation study showed that in cells treated with gamma-LA there was an increase in the binding of these inhibitors with CDK4, CDC2, and cyclin E. Flow cytometry study indicated an inhibition of cell cycle progression by gamma-LA (G0/G1 -45.4%, S - 34.6%, G2+M - 20.0% in control, and 70.5%, 21.0%, and 8.5%, respectively, in gamma-LA treated cells).	gamma-Linolenic Acid	230-238	cyclin dependent kinase 1	Homo sapiens	136-140
9683802-5	1998	A co-precipitation study showed that in cells treated with gamma-LA there was an increase in the binding of these inhibitors with CDK4, CDC2, and cyclin E. Flow cytometry study indicated an inhibition of cell cycle progression by gamma-LA (G0/G1 -45.4%, S - 34.6%, G2+M - 20.0% in control, and 70.5%, 21.0%, and 8.5%, respectively, in gamma-LA treated cells).	gamma-Linolenic Acid	230-238	cyclin dependent kinase 1	Homo sapiens	136-140
9731229-5	1998	In vitro phosphorylation and phosphopeptide mapping of several mutant proteins revealed that cdc2 kinase specifically phosphorylates the RS domain of SF2/ASF with serines 227, 238 and presumably 199 as major phosphorylation sites.	Serine	163-170	cyclin dependent kinase 1	Homo sapiens	93-97
9688315-5	1998	At a molecular level, cisplatin enhances cyclin B and p34cdc2 levels and histone H1 kinase activity in non-confluent, but not in confluent, cells.	Cisplatin	22-31	cyclin dependent kinase 1	Homo sapiens	54-61
9721872-4	1998	The first cellular effect observed with continuous exposure to 50 ng/ml paclitaxel (ID50) was mitotic arrest with an increase in the accumulation of cyclin B1 and stimulation of cdc2/cyclin B1 kinase in a time-dependent manner during a 36-h incubation.	Paclitaxel	72-82	cyclin dependent kinase 1	Homo sapiens	178-182
9683525-18	1998	Thus, the arrest of growth in G2 appears to be due to the inhibition of the p34(cdc2) kinase activity which is associated with the increased expression of p21(Cip1/Waf1) and increased phosphorylation on tyrosine of p34(cdc2).	Tyrosine	203-211	cyclin dependent kinase 1	Homo sapiens	80-84
9668078-4	1998	The number of mitotic cells was highest at 24 h (82%), then declined as arrested cells progressed into apoptosis, and barely no mitotic cells were present at 48-60 h. The time curves of paclitaxel-induced cyclin B1 accumulation and stimulation of Cdc2/cyclin B1 kinase activity were identical and superimposable to that of M phase arrest.	Paclitaxel	186-196	cyclin dependent kinase 1	Homo sapiens	247-251
9664138-8	1998	These observations suggest that genistein induces a G2/M arrest in human breast cancer cells, the mechanism of which is in part due to inhibition of kinase activities of cdc2 and cdk2, and decrease in cyclin B1 expression.	Genistein	32-41	cyclin dependent kinase 1	Homo sapiens	170-174
9668078-14	1998	Immune complex kinase assays in cell-free systems demonstrated that Bcl-2 protein can be a substrate of Cdc2/cyclin B1 kinase isolated from paclitaxel-treated cells arrested in M phase.	Paclitaxel	140-150	cyclin dependent kinase 1	Homo sapiens	104-108
9635591-3	1998	In this study, we have demonstrated the existence of an additional pathway, independent of the p34cdc2 kinase activation pathway, that leads to a G2 arrest in etoposide-treated cells.	Etoposide	159-168	cyclin dependent kinase 1	Homo sapiens	95-102
9635591-4	1998	Both the X-ray-induced and the etoposide-induced G2 arrest were associated with inhibition of the p34cdc2 H1 kinase activation pathway as judged by p34cdc2 H1 kinase activity and phosphorylation of cdc25C.	Etoposide	31-40	cyclin dependent kinase 1	Homo sapiens	98-105
9635591-4	1998	Both the X-ray-induced and the etoposide-induced G2 arrest were associated with inhibition of the p34cdc2 H1 kinase activation pathway as judged by p34cdc2 H1 kinase activity and phosphorylation of cdc25C.	Etoposide	31-40	cyclin dependent kinase 1	Homo sapiens	148-155
9614117-2	1998	These Ser/Thr sites are immediately followed by proline, a motif that is commonly seen in the substrates of cyclin-dependent kinases (Cdk) and mitogen-activated protein kinases.	Serine	6-9	cyclin dependent kinase 1	Homo sapiens	134-137
9614117-2	1998	These Ser/Thr sites are immediately followed by proline, a motif that is commonly seen in the substrates of cyclin-dependent kinases (Cdk) and mitogen-activated protein kinases.	Threonine	10-13	cyclin dependent kinase 1	Homo sapiens	134-137
9614117-2	1998	These Ser/Thr sites are immediately followed by proline, a motif that is commonly seen in the substrates of cyclin-dependent kinases (Cdk) and mitogen-activated protein kinases.	Proline	48-55	cyclin dependent kinase 1	Homo sapiens	134-137
9614117-3	1998	A previous study has shown that Cdc2 (Cdk1) indeed phosphorylates these p70(s6k) Ser/Thr residues in vitro.	Serine	81-84	cyclin dependent kinase 1	Homo sapiens	32-36
9614117-3	1998	A previous study has shown that Cdc2 (Cdk1) indeed phosphorylates these p70(s6k) Ser/Thr residues in vitro.	Serine	81-84	cyclin dependent kinase 1	Homo sapiens	38-42
9614117-3	1998	A previous study has shown that Cdc2 (Cdk1) indeed phosphorylates these p70(s6k) Ser/Thr residues in vitro.	Threonine	85-88	cyclin dependent kinase 1	Homo sapiens	32-36
9683525-0	1998	Regulation of the cell cycle at the G2/M boundary in metastatic melanoma cells by 12-O-tetradecanoyl phorbol-13-acetate (TPA) by blocking p34cdc2 kinase activity.	Tetradecanoylphorbol Acetate	82-119	cyclin dependent kinase 1	Homo sapiens	138-145
9683525-0	1998	Regulation of the cell cycle at the G2/M boundary in metastatic melanoma cells by 12-O-tetradecanoyl phorbol-13-acetate (TPA) by blocking p34cdc2 kinase activity.	Tetradecanoylphorbol Acetate	121-124	cyclin dependent kinase 1	Homo sapiens	138-145
9683525-7	1998	Examination of the levels of cyclins A and B1 demonstrated that the levels of these cyclins were not limiting for entrance into M. However, the addition of TPA blocked the increase in p34(cdc2)/cyclin B1 kinase activity.	Tetradecanoylphorbol Acetate	156-159	cyclin dependent kinase 1	Homo sapiens	188-192
9683525-8	1998	In cells treated with TPA, most p34(cdc2) was found in the slowly migrating forms on Western blots, which contained increased levels of phosphotyrosine.	Tetradecanoylphorbol Acetate	22-25	cyclin dependent kinase 1	Homo sapiens	36-40
9683525-8	1998	In cells treated with TPA, most p34(cdc2) was found in the slowly migrating forms on Western blots, which contained increased levels of phosphotyrosine.	Phosphotyrosine	136-151	cyclin dependent kinase 1	Homo sapiens	36-40
9664138-7	1998	Genistein induced expression of p21, and the increased levels of p21 were associated with increased binding of p21 with cdc2 and cdk2.	Genistein	0-9	cyclin dependent kinase 1	Homo sapiens	120-124
9665796-0	1998	Cdc2-independent induction of premature mitosis by okadaic acid in HeLa cells.	Okadaic Acid	51-63	cyclin dependent kinase 1	Homo sapiens	0-4
9703866-0	1998	Treatment of human glioblastoma cells with the staurosporine derivative CGP 41251 inhibits CDC2 and CDK2 kinase activity and increases radiation sensitivity.	Staurosporine	47-60	cyclin dependent kinase 1	Homo sapiens	91-95
9632748-4	1998	This stimulation was dependent on the activating phosphorylation of p34(cdc2) on Thr-161, which follows cyclin binding and is mediated by the cdk-activating kinase.	Threonine	81-84	cyclin dependent kinase 1	Homo sapiens	72-76
9611241-4	1998	Unlike other kinases such as cdc2 and SRPK1, which also phosphorylated serines at the RS domain, topo I/kinase required several SR dipeptide repeats.	Serine	71-78	cyclin dependent kinase 1	Homo sapiens	29-33
9614117-3	1998	A previous study has shown that Cdc2 (Cdk1) indeed phosphorylates these p70(s6k) Ser/Thr residues in vitro.	Threonine	85-88	cyclin dependent kinase 1	Homo sapiens	38-42
9573072-4	1998	CDT treatment was also shown to cause HeLa cells to accumulate the inactive, tyrosine-phosphorylated form of CDC2.	Tyrosine	77-85	cyclin dependent kinase 1	Homo sapiens	109-113
9578617-5	1998	Cyclin B-, but not cyclin A-, associated Cdc2 was subjected to regulation via Tyr phosphorylation, and phosphorylation states of Cdc25 correlated with cyclin B/Cdc2 kinase activity with some exceptions.	Tyrosine	78-81	cyclin dependent kinase 1	Homo sapiens	41-45
9618490-2	1998	We find that the Fas-induced activation of cdc2 and cdk2 in Jurkat cells is not dependent on protein synthesis, which is shut down very early during apoptosis before caspase-3 activation.	ammonium ferrous sulfate	17-20	cyclin dependent kinase 1	Homo sapiens	43-47
9618275-0	1998	Characterization of the enhancer-like okadaic acid response element region of the cyclin-dependent kinase 1 (p34cdc2) promoter.	Okadaic Acid	38-50	cyclin dependent kinase 1	Homo sapiens	82-107
9618275-0	1998	Characterization of the enhancer-like okadaic acid response element region of the cyclin-dependent kinase 1 (p34cdc2) promoter.	Okadaic Acid	38-50	cyclin dependent kinase 1	Homo sapiens	109-116
9618275-1	1998	Expression of the cdk1 (p34cdc2) gene is enhanced 5-10 fold as cells re-enter the cell cycle from quiescence in response to serum-refeeding or following exposure to the protein phosphatase 1/2A inhibitor okadaic acid.	Okadaic Acid	204-216	cyclin dependent kinase 1	Homo sapiens	18-22
9618275-1	1998	Expression of the cdk1 (p34cdc2) gene is enhanced 5-10 fold as cells re-enter the cell cycle from quiescence in response to serum-refeeding or following exposure to the protein phosphatase 1/2A inhibitor okadaic acid.	Okadaic Acid	204-216	cyclin dependent kinase 1	Homo sapiens	24-31
9618275-2	1998	Transient transfection analysis of nested deletions of the human cdk1 promoter identified regions that confer sensitivity to okadaic acid on a CAT-reporter gene.	Okadaic Acid	125-137	cyclin dependent kinase 1	Homo sapiens	65-69
9618275-8	1998	Enhancement of cdk1 expression appears dependent on 2 nonhomologous okadaic acid-sensitive promoter regions.	Okadaic Acid	68-80	cyclin dependent kinase 1	Homo sapiens	15-19
9871700-3	1998	Inhibitory activities toward cdc2 and other protein kinases were investigated, and the compound (21) with Ac-Cys-Pro-Lys-Lys-NHMe connected with the triethylene glycol spacer exhibited the most potent inhibition with relatively high selectivity.	CHEMBL266360	106-129	cyclin dependent kinase 1	Homo sapiens	29-33
9871700-3	1998	Inhibitory activities toward cdc2 and other protein kinases were investigated, and the compound (21) with Ac-Cys-Pro-Lys-Lys-NHMe connected with the triethylene glycol spacer exhibited the most potent inhibition with relatively high selectivity.	triethylene glycol	149-167	cyclin dependent kinase 1	Homo sapiens	29-33
9553063-13	1998	SBCRK and histidine-tagged CRK3 activities were inhibited by the purine analogue olomoucine with an IC50 of 28 and 42 microM, respectively, 5-6-fold higher than human p34(cdc2)/cyclinB.	Histidine	10-19	cyclin dependent kinase 1	Homo sapiens	171-175
9553063-13	1998	SBCRK and histidine-tagged CRK3 activities were inhibited by the purine analogue olomoucine with an IC50 of 28 and 42 microM, respectively, 5-6-fold higher than human p34(cdc2)/cyclinB.	purine	65-71	cyclin dependent kinase 1	Homo sapiens	171-175
9467949-4	1998	The p34cdc2 binding site on human p53 maps to one distinct C-terminal site LQIRGRERFE (aa 330-339) close to the corresponding phosphorylation site at serine 315.	Serine	150-156	cyclin dependent kinase 1	Homo sapiens	4-11
9515786-2	1998	Monomeric free CDKs do not possess enzymatic activity, largely due to the steric hindrance caused by the T-loop at the entrance of the catalytic cleft, making ATP inaccessible to the substrate.	Adenosine Triphosphate	159-162	cyclin dependent kinase 1	Homo sapiens	15-19
9427698-1	1998	Flavopiridol (NSC 649890; Behringwerke L86-8275, Marburg, Germany), is a potent inhibitor of cyclin dependent kinases (CDKs) 1, 2, and 4.	alvocidib	0-12	cyclin dependent kinase 1	Homo sapiens	93-136
9427698-8	1998	While flavopiridol caused cell cycle arrest with decline in CDK1 activity in PC3 cells, apoptosis of SUDHL4 cells occurred without evidence of cell cycle arrest.	alvocidib	6-18	cyclin dependent kinase 1	Homo sapiens	60-64
10732027-6	1998	When the cdc2 kinase is blocked in the porcine oocytes by BL I, MAP kinase, activated by okadaic acid treatment, is able to substitute cdc2 kinase and induce GVBD.	Okadaic Acid	89-101	cyclin dependent kinase 1	Homo sapiens	9-13
10732027-6	1998	When the cdc2 kinase is blocked in the porcine oocytes by BL I, MAP kinase, activated by okadaic acid treatment, is able to substitute cdc2 kinase and induce GVBD.	Okadaic Acid	89-101	cyclin dependent kinase 1	Homo sapiens	135-139
9586958-3	1998	The protein kinase inhibitor staurosporine and the temperature sensitive (ts) p34cdc2 mutant reduced induction by the alkylating agent methylmethane sulfonate (MMS) of the rodent gadd45 and gadd153 genes.	Methyl Methanesulfonate	135-158	cyclin dependent kinase 1	Homo sapiens	78-85
9586958-3	1998	The protein kinase inhibitor staurosporine and the temperature sensitive (ts) p34cdc2 mutant reduced induction by the alkylating agent methylmethane sulfonate (MMS) of the rodent gadd45 and gadd153 genes.	Methyl Methanesulfonate	160-163	cyclin dependent kinase 1	Homo sapiens	78-85
9615715-1	1998	[2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylp urine] (roscovitine) is a potent and selective inhibitor of cyclin-dependent kinases cdc2 and cdk2.	Roscovitine	0-70	cyclin dependent kinase 1	Homo sapiens	149-153
9615715-1	1998	[2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylp urine] (roscovitine) is a potent and selective inhibitor of cyclin-dependent kinases cdc2 and cdk2.	Roscovitine	72-83	cyclin dependent kinase 1	Homo sapiens	149-153
9543386-1	1998	Cdc25C is a dual-specificity protein kinase that controls entry into mitosis by dephosphorylating Cdc2 on both threonine 14 and tyrosine 15.	Threonine	111-120	cyclin dependent kinase 1	Homo sapiens	0-4
9543386-1	1998	Cdc25C is a dual-specificity protein kinase that controls entry into mitosis by dephosphorylating Cdc2 on both threonine 14 and tyrosine 15.	Tyrosine	128-136	cyclin dependent kinase 1	Homo sapiens	0-4
9492343-3	1998	Progression from G2 into M is controlled in part by a cyclin-dependent kinase (cyclin B/Cdk1) that is regulated by tyrosine phosphorylation.	Tyrosine	115-123	cyclin dependent kinase 1	Homo sapiens	88-92
9492343-5	1998	Activation of cyclin B/Cdk1 at the onset of mitosis is accomplished by a phosphatase, Cdc25C, that interacts with cyclin B/Cdk1 in an autocatalytic feedback loop to remove the inhibitory phosphate at Tyr15 and activate kinase activity.	Phosphates	187-196	cyclin dependent kinase 1	Homo sapiens	23-27
9492343-5	1998	Activation of cyclin B/Cdk1 at the onset of mitosis is accomplished by a phosphatase, Cdc25C, that interacts with cyclin B/Cdk1 in an autocatalytic feedback loop to remove the inhibitory phosphate at Tyr15 and activate kinase activity.	Phosphates	187-196	cyclin dependent kinase 1	Homo sapiens	123-127
9492343-9	1998	The isoflavone genistein inhibits tyrosine kinases, including one that phosphorylates Cdk1 on Tyr15.	Isoflavones	4-14	cyclin dependent kinase 1	Homo sapiens	86-90
9492343-9	1998	The isoflavone genistein inhibits tyrosine kinases, including one that phosphorylates Cdk1 on Tyr15.	Genistein	15-24	cyclin dependent kinase 1	Homo sapiens	86-90
9492343-10	1998	This kinase, p56/p53lyn is rapidly induced by treatments that trigger cell cycle checkpoints (ionizing radiation, cytosine arabinoside), suggesting that this kinase may actively delay the onset of mitosis by phosphorylating Tyr15 on Cdk1.	Cytarabine	114-134	cyclin dependent kinase 1	Homo sapiens	233-237
9743457-0	1998	Cisplatin-induced inhibition of p34cdc2 is abolished by 5-fluorouracil.	Cisplatin	0-9	cyclin dependent kinase 1	Homo sapiens	32-39
9743457-0	1998	Cisplatin-induced inhibition of p34cdc2 is abolished by 5-fluorouracil.	Fluorouracil	56-70	cyclin dependent kinase 1	Homo sapiens	32-39
9743457-6	1998	CDDP prevented activation of p34cdc2 by keeping cdc25C inactive and weel active.	Cisplatin	0-4	cyclin dependent kinase 1	Homo sapiens	29-36
9419978-6	1997	High levels of p21 protein were also found to be associated with inactive p34cdc2/cyclin B protein complex after treatment with paclitaxel.	Paclitaxel	128-138	cyclin dependent kinase 1	Homo sapiens	74-81
9438384-9	1998	Butyrolactone I, an inhibitor of cdc2 kinase, inhibited increases in Cx43 phosphorylation during mitosis.	butyrolactone I	0-15	cyclin dependent kinase 1	Homo sapiens	33-37
9438385-0	1998	Taxol-induced p34cdc2 kinase activation and apoptosis inhibited by 12-O-tetradecanoylphorbol-13-acetate in human breast MCF-7 carcinoma cells.	Paclitaxel	0-5	cyclin dependent kinase 1	Homo sapiens	14-21
9438385-0	1998	Taxol-induced p34cdc2 kinase activation and apoptosis inhibited by 12-O-tetradecanoylphorbol-13-acetate in human breast MCF-7 carcinoma cells.	Tetradecanoylphorbol Acetate	67-103	cyclin dependent kinase 1	Homo sapiens	14-21
9438385-3	1998	Here, we show that Taxol induced p34cdc2 kinase activity with a peak at 6 h in human breast carcinoma MCF-7 cells.	Paclitaxel	19-24	cyclin dependent kinase 1	Homo sapiens	33-40
9407133-0	1997	Proteolysis and tyrosine phosphorylation of p34cdc2/cyclin B.	Tyrosine	16-24	cyclin dependent kinase 1	Homo sapiens	44-51
9407133-1	1997	The role of MCM2 and initiation of DNA replication to allow tyrosine phosphorylation of p34cdc2.	Tyrosine	60-68	cyclin dependent kinase 1	Homo sapiens	88-95
9407133-5	1997	Cells arrested at G1/S by lack of nimQMCM2 contain p34(cdc2)/cyclin B, but p34(cdc2) remains tyrosine dephosphorylated, even after DNA damage.	Tyrosine	93-101	cyclin dependent kinase 1	Homo sapiens	79-83
9407133-7	1997	nimQMCM2, likely via initiation of DNA replication, is therefore required to trigger tyrosine phosphorylation of p34(cdc2) during the G1 to S transition, which may occur by inactivation of nimTcdc25.	Tyrosine	85-93	cyclin dependent kinase 1	Homo sapiens	117-121
9407133-9	1997	Initiation of DNA replication, which requires nimQMCM2, is apparently critical to switch mitotic regulation from the APC to include tyrosine phosphorylation of p34(cdc2) at G1/S.	Tyrosine	132-140	cyclin dependent kinase 1	Homo sapiens	164-168
9438385-5	1998	Olomoucine, a potent p34cdc2 inhibitor, effectively prevented Taxol-induced p34cdc2 kinase activation and subsequent apoptosis.	olomoucine	0-10	cyclin dependent kinase 1	Homo sapiens	21-28
9438385-5	1998	Olomoucine, a potent p34cdc2 inhibitor, effectively prevented Taxol-induced p34cdc2 kinase activation and subsequent apoptosis.	olomoucine	0-10	cyclin dependent kinase 1	Homo sapiens	76-83
9438385-5	1998	Olomoucine, a potent p34cdc2 inhibitor, effectively prevented Taxol-induced p34cdc2 kinase activation and subsequent apoptosis.	Paclitaxel	62-67	cyclin dependent kinase 1	Homo sapiens	21-28
9438385-5	1998	Olomoucine, a potent p34cdc2 inhibitor, effectively prevented Taxol-induced p34cdc2 kinase activation and subsequent apoptosis.	Paclitaxel	62-67	cyclin dependent kinase 1	Homo sapiens	76-83
9438385-6	1998	Furthermore, the treatment of cells with cyclin B1-specific antisense oligonucleotide also blocked Taxol-induced apoptosis, suggesting that cyclin B1-associated p34cdc2 kinase plays an important role in the induction of apoptosis by Taxol.	Oligonucleotides	70-85	cyclin dependent kinase 1	Homo sapiens	161-168
9438385-6	1998	Furthermore, the treatment of cells with cyclin B1-specific antisense oligonucleotide also blocked Taxol-induced apoptosis, suggesting that cyclin B1-associated p34cdc2 kinase plays an important role in the induction of apoptosis by Taxol.	Paclitaxel	99-104	cyclin dependent kinase 1	Homo sapiens	161-168
9438385-6	1998	Furthermore, the treatment of cells with cyclin B1-specific antisense oligonucleotide also blocked Taxol-induced apoptosis, suggesting that cyclin B1-associated p34cdc2 kinase plays an important role in the induction of apoptosis by Taxol.	Paclitaxel	233-238	cyclin dependent kinase 1	Homo sapiens	161-168
9438385-8	1998	TPA inhibited Taxol-mediated activation of p34cdc2 kinase by preventing the dephosphorylation of the Tyr-15 residue on p34cdc2 without altering the levels of Cdc2 and cyclin B1.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase 1	Homo sapiens	43-50
9438385-8	1998	TPA inhibited Taxol-mediated activation of p34cdc2 kinase by preventing the dephosphorylation of the Tyr-15 residue on p34cdc2 without altering the levels of Cdc2 and cyclin B1.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase 1	Homo sapiens	119-126
9438385-8	1998	TPA inhibited Taxol-mediated activation of p34cdc2 kinase by preventing the dephosphorylation of the Tyr-15 residue on p34cdc2 without altering the levels of Cdc2 and cyclin B1.	Paclitaxel	14-19	cyclin dependent kinase 1	Homo sapiens	43-50
9438385-8	1998	TPA inhibited Taxol-mediated activation of p34cdc2 kinase by preventing the dephosphorylation of the Tyr-15 residue on p34cdc2 without altering the levels of Cdc2 and cyclin B1.	Paclitaxel	14-19	cyclin dependent kinase 1	Homo sapiens	119-126
9438385-8	1998	TPA inhibited Taxol-mediated activation of p34cdc2 kinase by preventing the dephosphorylation of the Tyr-15 residue on p34cdc2 without altering the levels of Cdc2 and cyclin B1.	Tyrosine	101-104	cyclin dependent kinase 1	Homo sapiens	43-50
9438385-8	1998	TPA inhibited Taxol-mediated activation of p34cdc2 kinase by preventing the dephosphorylation of the Tyr-15 residue on p34cdc2 without altering the levels of Cdc2 and cyclin B1.	Tyrosine	101-104	cyclin dependent kinase 1	Homo sapiens	119-126
9438385-10	1998	These findings suggest that modulation of protein kinase C signaling can protect against Taxol-induced cell death by inhibiting p34cdc2 kinase activation.	Paclitaxel	89-94	cyclin dependent kinase 1	Homo sapiens	128-135
9631486-0	1998	Depressed p34cdc2 kinase activity and G2/M phase arrest induced by diallyl disulfide in HCT-15 cells.	diallyl disulfide	67-84	cyclin dependent kinase 1	Homo sapiens	10-17
9631486-4	1998	Consistent with the G2/M phase arrest, DADS exposure inhibited p34cdc2 kinase activity within four hours of treatment.	diallyl disulfide	39-43	cyclin dependent kinase 1	Homo sapiens	63-70
9631486-5	1998	The maximum depression in p34cdc2 kinase activity (53%) occurred when 25 microM DADS was added to the medium.	diallyl disulfide	80-84	cyclin dependent kinase 1	Homo sapiens	26-33
9631486-6	1998	The present studies suggest that depressed p34cdc2 kinase activity is likely one of the early cellular events that may account for the antiproliferative property of DADS.	diallyl disulfide	165-169	cyclin dependent kinase 1	Homo sapiens	43-50
9407044-2	1997	Dephosphorylation of threonine 14 and tyrosine 15 of CDK1 by the CDC25 phosphatases is a key step in the activation of the CDK1-cyclin B protein kinase.	Threonine	21-30	cyclin dependent kinase 1	Homo sapiens	53-57
9407044-2	1997	Dephosphorylation of threonine 14 and tyrosine 15 of CDK1 by the CDC25 phosphatases is a key step in the activation of the CDK1-cyclin B protein kinase.	Threonine	21-30	cyclin dependent kinase 1	Homo sapiens	123-127
9407044-2	1997	Dephosphorylation of threonine 14 and tyrosine 15 of CDK1 by the CDC25 phosphatases is a key step in the activation of the CDK1-cyclin B protein kinase.	Tyrosine	38-46	cyclin dependent kinase 1	Homo sapiens	53-57
9407044-2	1997	Dephosphorylation of threonine 14 and tyrosine 15 of CDK1 by the CDC25 phosphatases is a key step in the activation of the CDK1-cyclin B protein kinase.	Tyrosine	38-46	cyclin dependent kinase 1	Homo sapiens	123-127
9398320-6	1997	We present here evidence that cdc2 kinase is the major M-phase MAP4 kinase, and, further, we identify two phosphorylation sites within the proline-rich domain of MAP4.	Proline	139-146	cyclin dependent kinase 1	Homo sapiens	30-34
9398320-8	1997	A specific inhibitor of cdc2 kinase, butyrolactone I, inhibited phosphorylation of MAP4 both in mitotic HeLa cells and in the mitotic HeLa cell extract.	4-Butyrolactone	37-50	cyclin dependent kinase 1	Homo sapiens	24-28
9398320-10	1997	Ser-696 and Ser-787, both of which lie within SPXK consensus sequences for cdc2 kinase, were identified as phosphorylation sites in the proline-rich region of MAP4 in vivo and in vitro.	Serine	0-3	cyclin dependent kinase 1	Homo sapiens	75-79
9398320-10	1997	Ser-696 and Ser-787, both of which lie within SPXK consensus sequences for cdc2 kinase, were identified as phosphorylation sites in the proline-rich region of MAP4 in vivo and in vitro.	Serine	12-15	cyclin dependent kinase 1	Homo sapiens	75-79
9398320-10	1997	Ser-696 and Ser-787, both of which lie within SPXK consensus sequences for cdc2 kinase, were identified as phosphorylation sites in the proline-rich region of MAP4 in vivo and in vitro.	Proline	136-143	cyclin dependent kinase 1	Homo sapiens	75-79
9398320-12	1997	These results suggest that cdc2 kinase directly regulates microtubule dynamics at mitosis through phosphorylation of MAP4 at a number of sites, including Ser-787.	Serine	154-157	cyclin dependent kinase 1	Homo sapiens	27-31
9419978-8	1997	In NIH-OVCAR-3 cells, which are deficient in basal and paclitaxel-induced p21 expression, paclitaxel led to a prolonged activation of p34cdc2 and a delayed mitotic exit associated with apoptotic cell death.	Paclitaxel	55-65	cyclin dependent kinase 1	Homo sapiens	134-141
9419978-8	1997	In NIH-OVCAR-3 cells, which are deficient in basal and paclitaxel-induced p21 expression, paclitaxel led to a prolonged activation of p34cdc2 and a delayed mitotic exit associated with apoptotic cell death.	Paclitaxel	90-100	cyclin dependent kinase 1	Homo sapiens	134-141
9187128-4	1997	This G2-M arrest was mediated by persistent inactivation of the cyclin B1/cdc2 kinase complex characterized by both sustained accumulation of cyclin B1 and tyrosine phosphorylation of cdc2.	Tyrosine	156-164	cyclin dependent kinase 1	Homo sapiens	74-78
9371502-5	1997	Arsenite-induced G2 and mitotic delay are accompanied by accumulation of cyclin B1 and hyperphosphorylation of cdc2 and Mos proteins.	arsenite	0-8	cyclin dependent kinase 1	Homo sapiens	111-115
9315091-4	1997	Cdc2 was identified as the kinase responsible for the mitotic threonine phosphorylation by (1) immunodepletion of the mitotic Sam68 kinase from cell lysates with anti-Cdc2 antibodies, (2) inhibition of Sam68 phosphorylation in vitro and in vivo by the cyclin-dependent kinase inhibitor olomoucine and (3) phosphorylation of Sam68 by purified Cdc2.	Threonine	62-71	cyclin dependent kinase 1	Homo sapiens	0-4
9315091-4	1997	Cdc2 was identified as the kinase responsible for the mitotic threonine phosphorylation by (1) immunodepletion of the mitotic Sam68 kinase from cell lysates with anti-Cdc2 antibodies, (2) inhibition of Sam68 phosphorylation in vitro and in vivo by the cyclin-dependent kinase inhibitor olomoucine and (3) phosphorylation of Sam68 by purified Cdc2.	Threonine	62-71	cyclin dependent kinase 1	Homo sapiens	167-171
9315091-4	1997	Cdc2 was identified as the kinase responsible for the mitotic threonine phosphorylation by (1) immunodepletion of the mitotic Sam68 kinase from cell lysates with anti-Cdc2 antibodies, (2) inhibition of Sam68 phosphorylation in vitro and in vivo by the cyclin-dependent kinase inhibitor olomoucine and (3) phosphorylation of Sam68 by purified Cdc2.	Threonine	62-71	cyclin dependent kinase 1	Homo sapiens	167-171
9315091-4	1997	Cdc2 was identified as the kinase responsible for the mitotic threonine phosphorylation by (1) immunodepletion of the mitotic Sam68 kinase from cell lysates with anti-Cdc2 antibodies, (2) inhibition of Sam68 phosphorylation in vitro and in vivo by the cyclin-dependent kinase inhibitor olomoucine and (3) phosphorylation of Sam68 by purified Cdc2.	olomoucine	286-296	cyclin dependent kinase 1	Homo sapiens	0-4
9288185-0	1997	Transient tyrosine phosphorylation of p34cdc2 is an early event in radiation-induced apoptosis of prostate cancer cells.	Tyrosine	10-18	cyclin dependent kinase 1	Homo sapiens	38-45
9288185-6	1997	Subsequent analysis revealed that the substrate for this tyrosine phosphorylation is the serine/ threonine p34cdc2 protein kinase, a cell cycle regulatory protein that controls cell entry into mitosis.	Tyrosine	57-65	cyclin dependent kinase 1	Homo sapiens	107-114
9288185-8	1997	Arresting the cells in G0/G1 phase by pretreatment with suramin totally abrogated radiation-induced phosphorylation of p34cdc2 protein at the tyrosine residue, indicating that this posttranslational modification occurs in cell populations that escape G2 arrest and undergo apoptosis in response to radiation.	Suramin	56-63	cyclin dependent kinase 1	Homo sapiens	119-126
9288185-8	1997	Arresting the cells in G0/G1 phase by pretreatment with suramin totally abrogated radiation-induced phosphorylation of p34cdc2 protein at the tyrosine residue, indicating that this posttranslational modification occurs in cell populations that escape G2 arrest and undergo apoptosis in response to radiation.	Tyrosine	142-150	cyclin dependent kinase 1	Homo sapiens	119-126
9268380-2	1997	This step is mediated principally by the dephosphorylation of residues threonine 14 (Thr14) and tyrosine 15 (Tyr15) on the Cdc2 catalytic subunit.	Threonine	71-80	cyclin dependent kinase 1	Homo sapiens	123-127
9268380-2	1997	This step is mediated principally by the dephosphorylation of residues threonine 14 (Thr14) and tyrosine 15 (Tyr15) on the Cdc2 catalytic subunit.	Tyrosine	96-104	cyclin dependent kinase 1	Homo sapiens	123-127
9258408-6	1997	Heparin, a strong inhibitor of HUASMC proliferation, strongly down-modulated the levels of cyclin D1 mRNA and protein, cdk2 mRNA and cdc2 protein.	Heparin	0-7	cyclin dependent kinase 1	Homo sapiens	133-137
9260897-2	1997	RA did not affect cyclins D1, A, and E and cyclin-dependent kinase 2 (CDK2) expression, but significantly reduced cyclin D3 and CDK4 expression after 24 h. RA also inhibited cyclin B1 and CDC2 expression, possibly responsible for the reduction of the proportion of cells in G2 + M and S phases.	Tretinoin	0-2	cyclin dependent kinase 1	Homo sapiens	188-192
9235942-1	1997	The kinesin-related motor HsEg5 is essential for centrosome separation, and its association with centrosomes appears to be regulated by phosphorylation of tail residue threonine 927 by the p34(cdc2) protein kinase.	Threonine	168-177	cyclin dependent kinase 1	Homo sapiens	193-197
9288122-1	1997	BACKGROUND: Olomoucine and roscovitine are novel compounds that are designed to inhibit cyclin-dependent kinases (e.g., Cdk2 and cdc2).	olomoucine	12-22	cyclin dependent kinase 1	Homo sapiens	129-133
9288122-1	1997	BACKGROUND: Olomoucine and roscovitine are novel compounds that are designed to inhibit cyclin-dependent kinases (e.g., Cdk2 and cdc2).	Roscovitine	27-38	cyclin dependent kinase 1	Homo sapiens	129-133
9288122-3	1997	The purpose of this study was to determine (1) whether olomoucine and roscovitine inhibit Cdk2 and cdc2 kinase activities of the human gastric cancer cell line SIIA and (2) whether olomoucine and roscovitine block cell proliferation and cell cycle progression.	olomoucine	55-65	cyclin dependent kinase 1	Homo sapiens	99-103
9288122-3	1997	The purpose of this study was to determine (1) whether olomoucine and roscovitine inhibit Cdk2 and cdc2 kinase activities of the human gastric cancer cell line SIIA and (2) whether olomoucine and roscovitine block cell proliferation and cell cycle progression.	Roscovitine	70-81	cyclin dependent kinase 1	Homo sapiens	99-103
9288122-7	1997	RESULTS: Olomoucine and roscovitine completely blocked Cdk2 and cdc2 activities in SIIA cells.	olomoucine	9-19	cyclin dependent kinase 1	Homo sapiens	64-68
9288122-7	1997	RESULTS: Olomoucine and roscovitine completely blocked Cdk2 and cdc2 activities in SIIA cells.	Roscovitine	24-35	cyclin dependent kinase 1	Homo sapiens	64-68
9230211-0	1997	Activation of CDC 25 phosphatase and CDC 2 kinase involved in GL331-induced apoptosis.	GL 331	62-67	cyclin dependent kinase 1	Homo sapiens	14-19
9230211-2	1997	Abnormal activation of cyclin B-associated CDC 2 kinase has been implicated in apoptosis induced by cancer chemotherapeutic agents such as paclitaxel (Taxol) and etoposide (VP-16).	Paclitaxel	139-149	cyclin dependent kinase 1	Homo sapiens	43-48
9230211-2	1997	Abnormal activation of cyclin B-associated CDC 2 kinase has been implicated in apoptosis induced by cancer chemotherapeutic agents such as paclitaxel (Taxol) and etoposide (VP-16).	Paclitaxel	151-156	cyclin dependent kinase 1	Homo sapiens	43-48
9230211-2	1997	Abnormal activation of cyclin B-associated CDC 2 kinase has been implicated in apoptosis induced by cancer chemotherapeutic agents such as paclitaxel (Taxol) and etoposide (VP-16).	Etoposide	162-171	cyclin dependent kinase 1	Homo sapiens	43-48
9230211-3	1997	In this study, we found that the CDC 2 kinase could be transiently activated when nasopharyngeal carcinoma NPC-TW01 cells were treated for 3 h with a new anticancer agent, GL331.	GL 331	172-177	cyclin dependent kinase 1	Homo sapiens	33-38
9230211-4	1997	GL331 treatment also induced a concomitant increase in CDC 25A phosphatase activity and a reduced level of Tyr-15-phosphorylated CDC 2 in NPC-TW01 cells.	GL 331	0-5	cyclin dependent kinase 1	Homo sapiens	55-60
9230211-5	1997	Furthermore, subsequent apoptotic DNA fragmentation induced by GL331 could be interrupted by treatment of the cells with the cyclin B1-specific antisense oligonucleotides, suggesting that abnormal activation of cyclin B1-associated CDC 2 kinase and CDC 25A phosphatase was involved in GL331-induced apoptosis.	GL 331	63-68	cyclin dependent kinase 1	Homo sapiens	232-237
9371520-3	1997	We found that the signal generated by the DNA damage checkpoint in G2 was dominant over that from the spindle microtubule-assembly checkpoint, because the high Cdc2 activity present in nocodazole or Taxol-arrested cells was reduced by DNA damage.	Nocodazole	185-195	cyclin dependent kinase 1	Homo sapiens	160-164
9371520-3	1997	We found that the signal generated by the DNA damage checkpoint in G2 was dominant over that from the spindle microtubule-assembly checkpoint, because the high Cdc2 activity present in nocodazole or Taxol-arrested cells was reduced by DNA damage.	Paclitaxel	199-204	cyclin dependent kinase 1	Homo sapiens	160-164
9371520-6	1997	Consistent with this, Thr14/Tyr15 phosphorylation was induced when Cdc2 kinase activity was inhibited with butyrolactone-I.	butyrolactone I	107-122	cyclin dependent kinase 1	Homo sapiens	67-71
9371520-8	1997	Caffeine reversed the DNA damage-induced inhibition of Cdc2 by causing dephosphorylation of Cdc2, and this dephosphorylation still occurred even when the Cdc2 feedback loops were blocked with butyrolactone-I.	Caffeine	0-8	cyclin dependent kinase 1	Homo sapiens	55-59
9371520-8	1997	Caffeine reversed the DNA damage-induced inhibition of Cdc2 by causing dephosphorylation of Cdc2, and this dephosphorylation still occurred even when the Cdc2 feedback loops were blocked with butyrolactone-I.	Caffeine	0-8	cyclin dependent kinase 1	Homo sapiens	92-96
9371520-8	1997	Caffeine reversed the DNA damage-induced inhibition of Cdc2 by causing dephosphorylation of Cdc2, and this dephosphorylation still occurred even when the Cdc2 feedback loops were blocked with butyrolactone-I.	Caffeine	0-8	cyclin dependent kinase 1	Homo sapiens	92-96
9371520-8	1997	Caffeine reversed the DNA damage-induced inhibition of Cdc2 by causing dephosphorylation of Cdc2, and this dephosphorylation still occurred even when the Cdc2 feedback loops were blocked with butyrolactone-I.	4-Butyrolactone	192-205	cyclin dependent kinase 1	Homo sapiens	55-59
9371520-8	1997	Caffeine reversed the DNA damage-induced inhibition of Cdc2 by causing dephosphorylation of Cdc2, and this dephosphorylation still occurred even when the Cdc2 feedback loops were blocked with butyrolactone-I.	4-Butyrolactone	192-205	cyclin dependent kinase 1	Homo sapiens	92-96
9371520-8	1997	Caffeine reversed the DNA damage-induced inhibition of Cdc2 by causing dephosphorylation of Cdc2, and this dephosphorylation still occurred even when the Cdc2 feedback loops were blocked with butyrolactone-I.	4-Butyrolactone	192-205	cyclin dependent kinase 1	Homo sapiens	92-96
9376363-4	1997	Using cdc2 kinase, 7-10 mol of phosphoryl groups was incorporated per mole of MAP2, and more than 60% of the phosphates was distributed to the microtubule-binding region.	Phosphates	109-119	cyclin dependent kinase 1	Homo sapiens	6-10
9377557-0	1997	Sustained accumulation of the mitotic cyclins and tyrosine-phosphorylated p34cdc2 in human G1-S-arrested cancer cells but not untransformed cells.	Tyrosine	50-58	cyclin dependent kinase 1	Homo sapiens	74-81
9377557-3	1997	Under such conditions, indeed, cancer cells do continue to accumulate cyclin A, cyclin B1, and tyrosine-phosphorylated p34cdc2 to supranormal levels, a phenomenon that does not occur in untransformed, nonimmortalized human fibroblasts.	Tyrosine	95-103	cyclin dependent kinase 1	Homo sapiens	119-126
9344580-5	1997	Similarly, roscovitine, another CDK inhibitor with a 10-fold higher efficiency for both CDK1 and CDK2 as compared to olomoucine, showed the same effects at a 10-fold lower concentration.	Roscovitine	11-22	cyclin dependent kinase 1	Homo sapiens	88-92
9333120-4	1997	cdc2 antisense oligonucleotides blocked PTH-induced DNA synthesis and cell cycle progression.	Oligonucleotides	15-31	cyclin dependent kinase 1	Homo sapiens	0-4
9309154-1	1997	CDK inhibitor, Butyrolactone I inhibited CDK1, 2 and 5 in CDKs.	4-Butyrolactone	15-28	cyclin dependent kinase 1	Homo sapiens	41-54
9309154-1	1997	CDK inhibitor, Butyrolactone I inhibited CDK1, 2 and 5 in CDKs.	4-Butyrolactone	15-28	cyclin dependent kinase 1	Homo sapiens	58-62
9230211-5	1997	Furthermore, subsequent apoptotic DNA fragmentation induced by GL331 could be interrupted by treatment of the cells with the cyclin B1-specific antisense oligonucleotides, suggesting that abnormal activation of cyclin B1-associated CDC 2 kinase and CDC 25A phosphatase was involved in GL331-induced apoptosis.	Oligonucleotides	154-170	cyclin dependent kinase 1	Homo sapiens	232-237
9230211-5	1997	Furthermore, subsequent apoptotic DNA fragmentation induced by GL331 could be interrupted by treatment of the cells with the cyclin B1-specific antisense oligonucleotides, suggesting that abnormal activation of cyclin B1-associated CDC 2 kinase and CDC 25A phosphatase was involved in GL331-induced apoptosis.	GL 331	285-290	cyclin dependent kinase 1	Homo sapiens	232-237
9230211-7	1997	Our results revealed that GL331 could facilitate the association of CDC 25A with Raf-1, resulting in the cascade of CDC 25A phosphatase activation and CDC 2 kinase activation, as well as related signaling pathways, and ultimately causing apoptosis in cancer cells.	GL 331	26-31	cyclin dependent kinase 1	Homo sapiens	68-73
9300578-1	1997	We have studied the effects of olomoucine, a selective inhibitor of cdk2, cdc2 and MAP kinase, on the rate of proliferation and the cell cycle progression in human cancer cells in culture.	olomoucine	31-41	cyclin dependent kinase 1	Homo sapiens	74-78
17708961-3	1997	The mitotic regulators targeted for negative regulation by these checkpoints differ among cell types, but two conserved targets have emerged, the anaphase-promoting complex (APC) and tyrosine phosphorylation of p34(cdc2).	Tyrosine	183-191	cyclin dependent kinase 1	Homo sapiens	215-219
9187128-4	1997	This G2-M arrest was mediated by persistent inactivation of the cyclin B1/cdc2 kinase complex characterized by both sustained accumulation of cyclin B1 and tyrosine phosphorylation of cdc2.	Tyrosine	156-164	cyclin dependent kinase 1	Homo sapiens	184-188
9187128-7	1997	In low-dose treated G2-M-arrested FA-C cells, caffeine-dependent activation of cdc2 released the G2-M block but failed to protect against apoptosis, suggesting that apoptosis was not a direct consequence of persistent cdc2 kinase inactivation.	Caffeine	46-54	cyclin dependent kinase 1	Homo sapiens	79-83
9139719-9	1997	We also identified Ser-29 as the major Cdc2 kinase phosphorylation site in the p34 subunit.	Serine	19-22	cyclin dependent kinase 1	Homo sapiens	39-43
9201703-2	1997	In the present study we show that all the three Phosphatase-1 isoforms, alpha, gamma 1, delta, are phosphorylated by cdc2-cyclin B. Phosphorylation is specific for this kinase and involves a C-terminal Thr.	Threonine	202-205	cyclin dependent kinase 1	Homo sapiens	117-121
9201703-3	1997	This site is most likely Thr 320 in alpha (shown by others to be phosphorylated also by cdc2-cyclin A).	Threonine	25-28	cyclin dependent kinase 1	Homo sapiens	88-92
9201703-4	1997	Such Thr is conserved in gamma 1, delta and in the testis-specific gamma 2, and is the only Thr that fits the cdc2-consensus sequence in the C-terminal region.	Threonine	5-8	cyclin dependent kinase 1	Homo sapiens	110-114
9201703-4	1997	Such Thr is conserved in gamma 1, delta and in the testis-specific gamma 2, and is the only Thr that fits the cdc2-consensus sequence in the C-terminal region.	Threonine	92-95	cyclin dependent kinase 1	Homo sapiens	110-114
9201712-2	1997	In human cells, the mitosis-inducing kinase CDC2/cyclin B is inhibited by phosphorylation of threonine-14 and tyrosine-15, but the roles of these phosphorylations in enforcing checkpoints is not known.	Threonine	93-102	cyclin dependent kinase 1	Homo sapiens	44-48
9201712-2	1997	In human cells, the mitosis-inducing kinase CDC2/cyclin B is inhibited by phosphorylation of threonine-14 and tyrosine-15, but the roles of these phosphorylations in enforcing checkpoints is not known.	Tyrosine	110-118	cyclin dependent kinase 1	Homo sapiens	44-48
9164677-0	1997	Mechanism of action of a tyrphostin, 3,4-dihydroxy-alpha-cyanothiocinnamamide, in breast cancer cell growth inhibition involves the suppression of cyclin B1 and the functional activity of cyclin B1/p34cdc2 complex.	Tyrphostins	25-35	cyclin dependent kinase 1	Homo sapiens	198-205
9164677-0	1997	Mechanism of action of a tyrphostin, 3,4-dihydroxy-alpha-cyanothiocinnamamide, in breast cancer cell growth inhibition involves the suppression of cyclin B1 and the functional activity of cyclin B1/p34cdc2 complex.	tyrphostin 47	37-77	cyclin dependent kinase 1	Homo sapiens	198-205
9164677-8	1997	Our results suggest that a possible mechanism of tyrphostin action in breast cancer cells might involve the suppression of cyclin B1 and inhibition of the functional activity of cyclin B1/p34cdc2 complex.	Tyrphostins	49-59	cyclin dependent kinase 1	Homo sapiens	188-195
9168444-8	1997	TPA delayed DNA synthesis and expression of these genes, and suppressed Cdc2 kinase activity in the second round G2/M phase.	Tetradecanoylphorbol Acetate	0-3	cyclin dependent kinase 1	Homo sapiens	72-76
9122166-2	1997	In vitro, our previous studies showed that cdc2 kinase phosphorylates Thr-320 (T320) in PP-1, and that this leads to inhibition of enzyme activity.	Threonine	70-73	cyclin dependent kinase 1	Homo sapiens	43-47
9067571-12	1997	p27 is phosphorylated exclusively on serine by Erk1 and almost exclusively on threonine by Cdk1 in in vitro experiments.	Threonine	78-87	cyclin dependent kinase 1	Homo sapiens	91-95
9054461-6	1997	With regard to K8 phosphorylation at Ser-431, it increases dramatically upon stimulation of cells with epidermal growth factor (EGF) or after mitotic arrest and is the major K8 phosphorylated residue after incubating K8 immunoprecipitates with mitogen-activated protein or cdc2 kinases.	Serine	37-40	cyclin dependent kinase 1	Homo sapiens	273-277
9054461-9	1997	Furthermore, K8 Ser-431 phosphorylation occurs after EGF stimulation and during mitotic arrest and is likely to be mediated by mitogen-activated protein and cdc2 kinases, respectively.	Serine	16-19	cyclin dependent kinase 1	Homo sapiens	157-161
9093907-0	1997	Fas-induced changes in cdc2 and cdk2 kinase activity are not sufficient for triggering apoptosis in HUT-78 cells.	ammonium ferrous sulfate	0-3	cyclin dependent kinase 1	Homo sapiens	23-27
9093907-3	1997	To investigate whether Fas-induced cell death activated cdc2 and cdk2 kinases inappropriately, the human T lymphoma cells HUT-78, which express a high copy number of Fas, and two other previously characterized subclones of the same cell line which express mutant, cell death-deficient dominant-negative forms of Fas, were Fas-challenged and the changes in cdc2 and cdk2 kinase activity monitored.	ammonium ferrous sulfate	23-26	cyclin dependent kinase 1	Homo sapiens	56-60
9046330-0	1997	Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds.	olomoucine	96-106	cyclin dependent kinase 1	Homo sapiens	68-72
9006942-3	1997	Although the Ser-386 site can be phosphorylated by Cyclin B/Cdc2 in vitro, the kinase for the Ser-352 site is unknown.	Serine	13-16	cyclin dependent kinase 1	Homo sapiens	60-64
9034337-3	1997	Studies in mammalian cells have correlated induction of inhibitory tyrosine 15 (Y15) phosphorylation on p34cdc2 with the response to DNA damage.	Tyrosine	67-75	cyclin dependent kinase 1	Homo sapiens	104-111
9001210-0	1997	The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex.	Threonine	60-69	cyclin dependent kinase 1	Homo sapiens	52-56
9001210-3	1997	Phosphorylation of threonine 161 is required for the Cdc2-cyclin B complex to be catalytically active, whereas phosphorylation of threonine 14 and tyrosine 15 is inhibitory.	Threonine	19-28	cyclin dependent kinase 1	Homo sapiens	53-57
9001210-5	1997	Here we report the isolation of a novel human cDNA encoding a dual-specificity protein kinase (designated Myt1Hu) that preferentially phosphorylates Cdc2 on threonine 14 in a cyclin-dependent manner.	Threonine	157-166	cyclin dependent kinase 1	Homo sapiens	149-153
9008701-2	1997	2-aminopurine override of G2 arrest imposed by VM-26 or ICRF-193, which inhibit topoisomerase II (topo II)-dependent DNA decatenation, results in the activation of p34cdc2 kinase and entry into mitosis.	2-Aminopurine	0-13	cyclin dependent kinase 1	Homo sapiens	164-171
9030780-6	1997	It behaves as a competitive inhibitor for ATP binding to cdc2.	Adenosine Triphosphate	42-45	cyclin dependent kinase 1	Homo sapiens	57-61
9030781-0	1997	Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.	Roscovitine	36-47	cyclin dependent kinase 1	Homo sapiens	114-118
9030781-4	1997	Among a series of C2, N6, N9-substituted adenines tested on purified cdc2/cyclin B, 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine) displays high efficiency and high selectivity towards some cyclin-dependent kinases.	c2, n6, n9-substituted adenines	18-49	cyclin dependent kinase 1	Homo sapiens	69-73
9030781-4	1997	Among a series of C2, N6, N9-substituted adenines tested on purified cdc2/cyclin B, 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine) displays high efficiency and high selectivity towards some cyclin-dependent kinases.	Roscovitine	84-147	cyclin dependent kinase 1	Homo sapiens	69-73
9030781-15	1997	In vivo phosphorylation of vimentin on Ser55 by cdc2/cyclin B is inhibited by roscovitine.	Roscovitine	78-89	cyclin dependent kinase 1	Homo sapiens	48-52
9030781-16	1997	Through its unique selectivity for some cyclin-dependent kinases, roscovitine provides a useful antimitotic reagent for cell cycle studies and may prove interesting to control cells with deregulated cdc2, cdk2 or cdk5 kinase activities.	Roscovitine	66-77	cyclin dependent kinase 1	Homo sapiens	199-203
14646529-7	1997	Activation of cyclin B1-associated CDC 2 kinase seems to be an important G2/M event required for paclitaxel-induced apoptosis, and this activation of cyclin B1/CDC 2 kinase could be attributed to the increased activity of CDK 7 kinase.	Paclitaxel	97-107	cyclin dependent kinase 1	Homo sapiens	160-165
14646529-7	1997	Activation of cyclin B1-associated CDC 2 kinase seems to be an important G2/M event required for paclitaxel-induced apoptosis, and this activation of cyclin B1/CDC 2 kinase could be attributed to the increased activity of CDK 7 kinase.	Paclitaxel	97-107	cyclin dependent kinase 1	Homo sapiens	35-40
8980391-0	1996	Effect of melphalan and hyperthermia on p34cdc2 kinase activity in human melanoma cells.	Melphalan	10-19	cyclin dependent kinase 1	Homo sapiens	40-47
8980391-4	1996	At a concentration of 8.5 micrograms ml-1, which reduced cell growth by 50% at 37 degrees C, melphalan inhibited p34cdc2 kinase activity as a consequence of an increased tyrosine phosphorylation of the protein.	Melphalan	93-102	cyclin dependent kinase 1	Homo sapiens	113-120
8980391-5	1996	A similar inhibitory effect on p34cdc2 kinase was obtained when the lowest melphalan concentration (2.5 micrograms ml-1) was used under hyperthermic conditions.	Melphalan	75-84	cyclin dependent kinase 1	Homo sapiens	31-38
21541623-3	1996	As a cytostatic mechanism, however, Flavopiridol strongly inhibits the cyclin-dependent kinases (cdk1, cdk2, cdk4, cdk7), with the potential to cause inhibition of cell cycle progression in G(1) and G(2) by multiple mechanisms relatable to cdk inhibition.	alvocidib	36-48	cyclin dependent kinase 1	Homo sapiens	97-101
8940249-5	1996	After release from mimosine treatment, 84% of the cell population remained in G1 up to 8 h. Treating breast cancer cells with 400 microM mimosine for 24 h inhibited cyclin E- and cyclin A-associated kinase activity by 85% or more, although immunoblots using anti-cyclin A, cyclin E, cdc2, and cdk2 antibodies showed that these key subunits were still present in the cells at pretreatment levels.	Mimosine	137-145	cyclin dependent kinase 1	Homo sapiens	283-287
8910474-6	1996	Fas-induced apoptosis was completely inhibited by butyrolactone I, a specific inhibitor of Cdc2 kinase.	ammonium ferrous sulfate	0-3	cyclin dependent kinase 1	Homo sapiens	91-95
8910474-6	1996	Fas-induced apoptosis was completely inhibited by butyrolactone I, a specific inhibitor of Cdc2 kinase.	butyrolactone I	50-65	cyclin dependent kinase 1	Homo sapiens	91-95
8910474-8	1996	Finally, we have found that "Fas-responsive element" was located between nucleotides -730 and -552 of the cdc2 promoter and was responsive for transcriptional activation of the cdc2 gene during Fas-induced apoptosis.	ammonium ferrous sulfate	29-32	cyclin dependent kinase 1	Homo sapiens	106-110
8910474-8	1996	Finally, we have found that "Fas-responsive element" was located between nucleotides -730 and -552 of the cdc2 promoter and was responsive for transcriptional activation of the cdc2 gene during Fas-induced apoptosis.	ammonium ferrous sulfate	29-32	cyclin dependent kinase 1	Homo sapiens	177-181
8910474-8	1996	Finally, we have found that "Fas-responsive element" was located between nucleotides -730 and -552 of the cdc2 promoter and was responsive for transcriptional activation of the cdc2 gene during Fas-induced apoptosis.	ammonium ferrous sulfate	194-197	cyclin dependent kinase 1	Homo sapiens	106-110
8910474-8	1996	Finally, we have found that "Fas-responsive element" was located between nucleotides -730 and -552 of the cdc2 promoter and was responsive for transcriptional activation of the cdc2 gene during Fas-induced apoptosis.	ammonium ferrous sulfate	194-197	cyclin dependent kinase 1	Homo sapiens	177-181
8910474-9	1996	These results indicate that aberrant activation of Cdc2 is associated with Fas-induced apoptosis of hematopoietic cells, and that the mechanism of cdc2 transcription during Fas-induced apoptosis is different from that in normal cell cycle control.	ammonium ferrous sulfate	75-78	cyclin dependent kinase 1	Homo sapiens	51-55
9042196-0	1996	Antitumor effects of butyrolactone I, a selective cdc2 kinase inhibitor, on human lung cancer cell lines.	butyrolactone I	21-36	cyclin dependent kinase 1	Homo sapiens	50-54
9042196-1	1996	Butyrolactone I, which is a naturally occurring specific inhibitor of the cdc2 kinase family, showed antitumor effects on several non-small- and small-cell-lung cancer cell lines with IC50 values the order of 50 micrograms/ml on the former.	butyrolactone I	0-15	cyclin dependent kinase 1	Homo sapiens	74-78
9042196-3	1996	The cdc2 kinase activity of PC-14 cells was inhibited by treatment with 20 micrograms/ml butyrolactone I, a concentration comparable to the IC50 value, for 2 hours.	4-Butyrolactone	89-102	cyclin dependent kinase 1	Homo sapiens	4-8
9042196-4	1996	Longer exposure to butyrolactone I (&gt; 24 hours) reduced the cdc2 kinase protein level.	4-Butyrolactone	19-32	cyclin dependent kinase 1	Homo sapiens	63-67
9042196-6	1996	These results suggest that butyrolactone I actually acts on cdc2 kinase, rather than other cdk kinases, in PC-14 cells.	4-Butyrolactone	27-40	cyclin dependent kinase 1	Homo sapiens	60-64
8895733-1	1996	Flavopiridol (NSC 649890, L86-8275), a potent inhibitor of cyclin-dependent kinase 1/p34cdc2 phosphorylation and kinase activity, is currently undergoing Phase I clinical testing as a potential antineoplastic agent.	alvocidib	0-12	cyclin dependent kinase 1	Homo sapiens	59-84
8895733-1	1996	Flavopiridol (NSC 649890, L86-8275), a potent inhibitor of cyclin-dependent kinase 1/p34cdc2 phosphorylation and kinase activity, is currently undergoing Phase I clinical testing as a potential antineoplastic agent.	alvocidib	0-12	cyclin dependent kinase 1	Homo sapiens	85-92
8944784-0	1996	Vanadate triggers the transition from chromosome condensation to decondensation in a mitotic mutant (tsTM13) inactivation of p34cdc2/H1 kinase and dephosphorylation of mitosis-specific histone H3.	Vanadates	0-8	cyclin dependent kinase 1	Homo sapiens	125-132
8944784-4	1996	In the presence of vanadate, the H1 kinase activity dropped to near normal levels and the amount of the inactive from of p34cdc2 protein phosphorylated at a tyrosine residue was increased.	Vanadates	19-27	cyclin dependent kinase 1	Homo sapiens	121-128
8944784-4	1996	In the presence of vanadate, the H1 kinase activity dropped to near normal levels and the amount of the inactive from of p34cdc2 protein phosphorylated at a tyrosine residue was increased.	Tyrosine	157-165	cyclin dependent kinase 1	Homo sapiens	121-128
8910336-6	1996	Using antibodies to Lck and to the cyclin-dependent serine kinase, Cdc2, as well as the cyclin-dependent kinase affinity resin, Suc1-agarose, we detected a stable interaction between Lck and Cdc2.	suc1	128-132	cyclin dependent kinase 1	Homo sapiens	191-195
8910336-6	1996	Using antibodies to Lck and to the cyclin-dependent serine kinase, Cdc2, as well as the cyclin-dependent kinase affinity resin, Suc1-agarose, we detected a stable interaction between Lck and Cdc2.	Sepharose	133-140	cyclin dependent kinase 1	Homo sapiens	191-195
8910383-0	1996	Sequential dephosphorylation of p34(cdc2) on Thr-14 and Tyr-15 at the prophase/metaphase transition.	Threonine	45-48	cyclin dependent kinase 1	Homo sapiens	36-40
8910383-0	1996	Sequential dephosphorylation of p34(cdc2) on Thr-14 and Tyr-15 at the prophase/metaphase transition.	Tyrosine	56-59	cyclin dependent kinase 1	Homo sapiens	36-40
8910383-2	1996	During the prophase/metaphase transition, the inactive, Thr-14/Tyr-15 phosphorylated form of p34(cdc2) (TP-YP) is modified to an active, Thr-14/Tyr-15 dephosphorylated form (T-Y) by the cdc25 dual-specificity phosphatase.	Threonine	56-59	cyclin dependent kinase 1	Homo sapiens	97-101
8910383-2	1996	During the prophase/metaphase transition, the inactive, Thr-14/Tyr-15 phosphorylated form of p34(cdc2) (TP-YP) is modified to an active, Thr-14/Tyr-15 dephosphorylated form (T-Y) by the cdc25 dual-specificity phosphatase.	Tyrosine	63-66	cyclin dependent kinase 1	Homo sapiens	97-101
8840958-5	1996	Specific tetrapeptide inhibitors of ICE (Acetyl-Tyr-Val-Ala-Asp-chloromethylketone) or CPP32beta (Acetyl-Asp-Glu-Val-Asp-aldehyde) prevented the anti-Fas antibody-mediated activation of p34cdc2 and inhibited apoptosis.	N-acetyl-tyrosyl-valyl-alanyl-aspartyl chloromethyl ketone	41-82	cyclin dependent kinase 1	Homo sapiens	186-193
9552418-2	1997	This delay of mitotic entry is controlled, at least in part, by the repression of Cdc2 kinase activity by the phosphorylation of two conserved residues (Thr14 and Tyr15) within the ATP-binding pocket of the Cdc2 catalytic subunit.	Adenosine Triphosphate	181-184	cyclin dependent kinase 1	Homo sapiens	82-86
9552418-2	1997	This delay of mitotic entry is controlled, at least in part, by the repression of Cdc2 kinase activity by the phosphorylation of two conserved residues (Thr14 and Tyr15) within the ATP-binding pocket of the Cdc2 catalytic subunit.	Adenosine Triphosphate	181-184	cyclin dependent kinase 1	Homo sapiens	207-211
9018099-3	1996	We investigated the effects of 2-hydroxy-17beta-estradiol, a cell proliferator, and 2-methoxy-17beta-estradiol, a potent inhibitor of cell growth, on the levels and activity of p34(cdc2) and on the levels of PCNA, as well as on protein phosphorylation in MCF-7 cells.	2-Methoxyestradiol	84-110	cyclin dependent kinase 1	Homo sapiens	181-185
9018099-4	1996	2-Hydroxyestradiol increased p34(cdc2) activity at G1/S and elevated PCNA levels during S-phase.	2-hydroxyestradiol	0-18	cyclin dependent kinase 1	Homo sapiens	33-37
9018099-5	1996	2-Methoxyestradiol caused unscheduled activation of p34(cdc2) in S-phase and decreased levels of p34(cdc2) and PCNA during G2/M.	2-Methoxyestradiol	0-18	cyclin dependent kinase 1	Homo sapiens	56-60
9018099-5	1996	2-Methoxyestradiol caused unscheduled activation of p34(cdc2) in S-phase and decreased levels of p34(cdc2) and PCNA during G2/M.	2-Methoxyestradiol	0-18	cyclin dependent kinase 1	Homo sapiens	101-105
8837615-0	1996	Selective radiosensitization of p53-deficient cells by caffeine-mediated activation of p34cdc2 kinase.	Caffeine	55-63	cyclin dependent kinase 1	Homo sapiens	87-94
8837615-6	1996	We demonstrate that abrogation of G2 arrest by caffeine-mediated activation of p34cdc2 kinase results in the selective sensitization of p53-deficient primary and tumor cells to irradiation-induced apoptosis.	Caffeine	47-55	cyclin dependent kinase 1	Homo sapiens	79-86
8831555-8	1996	Cyclin B1/Cdc2 kinase activity decreased after BFA treatment in HL60 cells, indicating that BFA-induced DNA fragmentation was independent of a cyclin B1/Cdc2 kinase upregulation pathway.	Brefeldin A	47-50	cyclin dependent kinase 1	Homo sapiens	10-14
8831555-8	1996	Cyclin B1/Cdc2 kinase activity decreased after BFA treatment in HL60 cells, indicating that BFA-induced DNA fragmentation was independent of a cyclin B1/Cdc2 kinase upregulation pathway.	Brefeldin A	92-95	cyclin dependent kinase 1	Homo sapiens	10-14
8800197-8	1996	After UV B-irradiation the inactivation of Cdk1 was less pronounced and only partially diminished in the presence of caffeine.	Caffeine	117-125	cyclin dependent kinase 1	Homo sapiens	43-47
8816913-1	1996	Studies on the link between cellular signalling and cell cycle control at the G2 checkpoint have shown that, in HeLa cells, epidermal growth factor (EGF) and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) rapidly inhibit the G2-M transition by preventing the key component of mitosis-promoting factor (MPF), p34cdc2, from expressing protein kinase activity.	Phorbol Esters	162-175	cyclin dependent kinase 1	Homo sapiens	322-329
8816913-1	1996	Studies on the link between cellular signalling and cell cycle control at the G2 checkpoint have shown that, in HeLa cells, epidermal growth factor (EGF) and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) rapidly inhibit the G2-M transition by preventing the key component of mitosis-promoting factor (MPF), p34cdc2, from expressing protein kinase activity.	Tetradecanoylphorbol Acetate	176-212	cyclin dependent kinase 1	Homo sapiens	322-329
8816913-2	1996	The kinase activity of active MPF is not inhibited; rather, the conversion of pre-MPF to MPF, i.e., the activating dephosphorylation of p34cdc2, at tyrosine is rapidly blocked (Barth and Kinzel, 1994, Exp.	Tyrosine	148-156	cyclin dependent kinase 1	Homo sapiens	136-143
8752210-1	1996	Activation of the cyclin-dependent kinases to promote cell cycle progression requires their association with cyclins as well as phosphorylation of a threonine (residue 161 in human p34cdc2).	Threonine	149-158	cyclin dependent kinase 1	Homo sapiens	181-188
8705993-7	1996	Other studies with glutathione S-transferase-Lyn fusion proteins demonstrate that the binding of Lyn to nuclear Cdc2 is associated with inhibition of Cdc2 activity.	Glutathione	19-30	cyclin dependent kinase 1	Homo sapiens	112-116
8705993-7	1996	Other studies with glutathione S-transferase-Lyn fusion proteins demonstrate that the binding of Lyn to nuclear Cdc2 is associated with inhibition of Cdc2 activity.	Glutathione	19-30	cyclin dependent kinase 1	Homo sapiens	150-154
8761290-8	1996	In addition, TPA-treated cells showed high levels of cyclin B and cdc2 proteins, however no activation of cdc2 was detected.	Tetradecanoylphorbol Acetate	13-16	cyclin dependent kinase 1	Homo sapiens	66-70
8667426-12	1996	Biochemical markers indicative of the G2/M transition, including the activation of cyclin B1/Cdc2 kinase and the suppression of Cdc2 threonine-14 and tyrosine-15 phosphorylation, were detected in irradiated cells treated with UCN-01.	Threonine	133-142	cyclin dependent kinase 1	Homo sapiens	128-132
8670863-0	1996	Two S-phase checkpoint systems, one involving the function of both BIME and Tyr15 phosphorylation of p34cdc2, inhibit NIMA and prevent premature mitosis.	nima	118-122	cyclin dependent kinase 1	Homo sapiens	101-108
8670863-2	1996	The first responds to the rate of DNA replication and inhibits mitosis via tyrosine phosphorylation of p34cdc2.	Tyrosine	75-83	cyclin dependent kinase 1	Homo sapiens	103-110
8670863-3	1996	Cells unable to tyrosine phosphorylate p34cdc2 are therefore viable but are unable to tolerate low levels of hydroxyurea and prematurely enter lethal mitosis when S-phase is slowed.	Tyrosine	16-24	cyclin dependent kinase 1	Homo sapiens	39-46
8670863-4	1996	However, if the NIMA mitosis-promoting kinase is inactivated then non-tyrosine-phosphorylated p34cdc2 cannot promote cells prematurely into mitosis.	Tyrosine	70-78	cyclin dependent kinase 1	Homo sapiens	94-101
8670863-5	1996	Lack of tyrosine-phosphorylated p34cdc2 also cannot promote mitosis, or lethality, if DNA replication is arrested, demonstrating the presence of a second S-phase checkpoint mechanism over mitotic initiation which we show involves the function of BIME.	Tyrosine	8-16	cyclin dependent kinase 1	Homo sapiens	32-39
8670863-6	1996	In order to overcome the S-phase arrest checkpoint over mitosis it is necessary both to prevent tyrosine phosphorylation of p34cdc2 and also to inactivate BIME.	Tyrosine	96-104	cyclin dependent kinase 1	Homo sapiens	124-131
8670863-7	1996	Lack of tyrosine phosphorylation of p34cdc2 allows precocious expression of NIMA during S-phase arrest, and lack of BIME then allows activation of this prematurely expressed NIMA by phosphorylation.	Tyrosine	8-16	cyclin dependent kinase 1	Homo sapiens	36-43
8674031-1	1996	Flavopiridol (L86-8275), a N-methylpiperidinyl, chlorophenyl flavone, can inhibit cell cycle progression in either G1 or G2 and is a potent cyclin-dependent kinase (CDK) 1 inhibitor.	alvocidib	0-12	cyclin dependent kinase 1	Homo sapiens	140-171
8674031-1	1996	Flavopiridol (L86-8275), a N-methylpiperidinyl, chlorophenyl flavone, can inhibit cell cycle progression in either G1 or G2 and is a potent cyclin-dependent kinase (CDK) 1 inhibitor.	monoethylglycinexylidide	14-17	cyclin dependent kinase 1	Homo sapiens	140-171
8663071-4	1996	The cellular effects of chelerythrine are not due to either direct or indirect inhibition of the known mitotic regulator p34(cdc2)/cyclin B kinase.	chelerythrine	24-37	cyclin dependent kinase 1	Homo sapiens	125-129
8799831-6	1996	We also show that treatment of metaphase-arrested HeLa cells with staurosporine and olomoucine, inhibitors of p34cdc2 and other protein kinases, rapidly induces reassembly of interphase nuclei and dephosphorylation of histone H1 without chromosome segregation.	Staurosporine	66-79	cyclin dependent kinase 1	Homo sapiens	110-117
8799831-6	1996	We also show that treatment of metaphase-arrested HeLa cells with staurosporine and olomoucine, inhibitors of p34cdc2 and other protein kinases, rapidly induces reassembly of interphase nuclei and dephosphorylation of histone H1 without chromosome segregation.	olomoucine	84-94	cyclin dependent kinase 1	Homo sapiens	110-117
8662825-7	1996	Cdc2 is likely to be inhibited by Thr-14/Tyr-15 phosphorylation after irradiation because Cdc2 was tyrosine-phosphorylated, and recombinant Cdc25 was able to increase its kinase activity significantly.	Threonine	34-37	cyclin dependent kinase 1	Homo sapiens	0-4
8662825-7	1996	Cdc2 is likely to be inhibited by Thr-14/Tyr-15 phosphorylation after irradiation because Cdc2 was tyrosine-phosphorylated, and recombinant Cdc25 was able to increase its kinase activity significantly.	Threonine	34-37	cyclin dependent kinase 1	Homo sapiens	90-94
8662825-7	1996	Cdc2 is likely to be inhibited by Thr-14/Tyr-15 phosphorylation after irradiation because Cdc2 was tyrosine-phosphorylated, and recombinant Cdc25 was able to increase its kinase activity significantly.	Tyrosine	41-44	cyclin dependent kinase 1	Homo sapiens	0-4
8662825-7	1996	Cdc2 is likely to be inhibited by Thr-14/Tyr-15 phosphorylation after irradiation because Cdc2 was tyrosine-phosphorylated, and recombinant Cdc25 was able to increase its kinase activity significantly.	Tyrosine	41-44	cyclin dependent kinase 1	Homo sapiens	90-94
8662825-7	1996	Cdc2 is likely to be inhibited by Thr-14/Tyr-15 phosphorylation after irradiation because Cdc2 was tyrosine-phosphorylated, and recombinant Cdc25 was able to increase its kinase activity significantly.	Tyrosine	99-107	cyclin dependent kinase 1	Homo sapiens	0-4
8662825-7	1996	Cdc2 is likely to be inhibited by Thr-14/Tyr-15 phosphorylation after irradiation because Cdc2 was tyrosine-phosphorylated, and recombinant Cdc25 was able to increase its kinase activity significantly.	Tyrosine	99-107	cyclin dependent kinase 1	Homo sapiens	90-94
8662825-8	1996	Taken together, these results suggest that different CDKs are inhibited by different mechanisms following UV-induced DNA damage: Cdk2 is inhibited by the elevated level of p21; Cdk4 is inhibited by cooperation of p21 with other CDK inhibitors, like p27, and possibly by phosphorylation; and Cdc2 is inhibited by Thr-14/Tyr-15 phosphorylation.	Threonine	312-315	cyclin dependent kinase 1	Homo sapiens	53-57
8662825-8	1996	Taken together, these results suggest that different CDKs are inhibited by different mechanisms following UV-induced DNA damage: Cdk2 is inhibited by the elevated level of p21; Cdk4 is inhibited by cooperation of p21 with other CDK inhibitors, like p27, and possibly by phosphorylation; and Cdc2 is inhibited by Thr-14/Tyr-15 phosphorylation.	Threonine	312-315	cyclin dependent kinase 1	Homo sapiens	53-56
8662825-8	1996	Taken together, these results suggest that different CDKs are inhibited by different mechanisms following UV-induced DNA damage: Cdk2 is inhibited by the elevated level of p21; Cdk4 is inhibited by cooperation of p21 with other CDK inhibitors, like p27, and possibly by phosphorylation; and Cdc2 is inhibited by Thr-14/Tyr-15 phosphorylation.	Tyrosine	319-322	cyclin dependent kinase 1	Homo sapiens	53-57
8662825-8	1996	Taken together, these results suggest that different CDKs are inhibited by different mechanisms following UV-induced DNA damage: Cdk2 is inhibited by the elevated level of p21; Cdk4 is inhibited by cooperation of p21 with other CDK inhibitors, like p27, and possibly by phosphorylation; and Cdc2 is inhibited by Thr-14/Tyr-15 phosphorylation.	Tyrosine	319-322	cyclin dependent kinase 1	Homo sapiens	53-56
8626584-3	1996	Dominant negative mutants of CDC2, CDK2, and CDK3 each suppressed apoptosis induced by both staurosporine and tumor necrosis factor alpha, whereas a dominant negative mutant of CDK5 was without effect.	Staurosporine	92-105	cyclin dependent kinase 1	Homo sapiens	29-33
8622943-1	1996	To determine if nitration of tyrosine residues by peroxynitrite (PN), which can be generated endogenously, can disrupt the phosphorylation of tyrosine residues in proteins involved in cell signaling networks, we studied the effect of PN-promoted nitration of tyrosine residues in a pentadecameric peptide, cdc2(6-20)NH2, on the ability of the peptide to be phosphorylated.	Peroxynitrous Acid	65-67	cyclin dependent kinase 1	Homo sapiens	306-310
8622943-2	1996	cdc2(6-20)NH2 corresponds to the tyrosine phosphorylation site of p34cdc2 kinase, which is phosphorylated by lck kinase (lymphocyte-specific tyrosine kinase, p56lck).	Tyrosine	33-41	cyclin dependent kinase 1	Homo sapiens	0-4
8610110-2	1996	The discovery of specific inhibitors of CDKs such as polyhydroxylated flavones has opened the way to investigation and design of antimitotic compounds.	polyhydroxylated flavones	53-78	cyclin dependent kinase 1	Homo sapiens	40-44
8610110-3	1996	A novel flavone, (-)-cis-5,7-dihydroxyphenyl-8-[4-(3-hydroxy-1-methyl)piperidinyl] -4H-1-benzopyran-4-one hydrochloride hemihydrate (L868276), is a potent inhibitor of CDKs.	flavone	8-15	cyclin dependent kinase 1	Homo sapiens	168-172
8610110-7	1996	The analysis of the position of this phenyl ring not only explains the great differences of kinase inhibition among the flavonoid inhibitors but also explains the specificity of L868276 to inhibit CDK2 and CDC2.	L 868276	178-185	cyclin dependent kinase 1	Homo sapiens	206-210
8718673-4	1996	Contrary to the p34cdc2 mediated N-terminal phosphorylation (at ser-55) which can disassemble vimentin intermediate filaments (IF) in vitro, p37 protein kinase phosphorylates vimentin-IF without obviously affecting its structure in vitro.	Serine	64-67	cyclin dependent kinase 1	Homo sapiens	16-23
8718673-7	1996	Transfection of cells with vimentin cDNA lacking the p34cdc2 phosphorylation site (ser55:ala) effectively prevents mitotic cells from disassembling their IF.	Alanine	89-92	cyclin dependent kinase 1	Homo sapiens	53-60
8631817-19	1996	Recombinant DUT-N was specifically phosphorylated on Ser-11 in vitro with immunoprecipitated p34(cdc2).	dut-n	12-17	cyclin dependent kinase 1	Homo sapiens	97-101
8631817-19	1996	Recombinant DUT-N was specifically phosphorylated on Ser-11 in vitro with immunoprecipitated p34(cdc2).	ser-11	53-59	cyclin dependent kinase 1	Homo sapiens	97-101
8626381-5	1996	We found that cdc2 gene expression was blocked by okadaic acid, but stimulated by protein phosphatase 2A.	Okadaic Acid	50-62	cyclin dependent kinase 1	Homo sapiens	14-18
8626437-1	1996	Exposure of human B-cell precursors (BCP) to ionizing radiation results in cell cycle arrest at the G2-M checkpoint as a result of inhibitory tyrosine phosphorylation of p34cdc2 .	Tyrosine	142-150	cyclin dependent kinase 1	Homo sapiens	170-177
8626437-2	1996	Here, we show that ionizing radiation promotes physical interactions between p34cdc2 and the Src family protein-tyrosine kinase Lyn in the cytoplasm of human BCP leading to tyrosine phosphorylation of p34cdc2.	Tyrosine	112-120	cyclin dependent kinase 1	Homo sapiens	77-84
8626437-2	1996	Here, we show that ionizing radiation promotes physical interactions between p34cdc2 and the Src family protein-tyrosine kinase Lyn in the cytoplasm of human BCP leading to tyrosine phosphorylation of p34cdc2.	Tyrosine	112-120	cyclin dependent kinase 1	Homo sapiens	201-208
8626437-4	1996	Furthermore, Lyn kinase physically associated with and tyrosine-phosphorylated p34cdc2 kinase in vivo when co-expressed in COS-7 cells.	Tyrosine	55-63	cyclin dependent kinase 1	Homo sapiens	79-86
8626437-4	1996	Furthermore, Lyn kinase physically associated with and tyrosine-phosphorylated p34cdc2 kinase in vivo when co-expressed in COS-7 cells.	carbonyl sulfide	123-126	cyclin dependent kinase 1	Homo sapiens	79-86
8640763-6	1996	Although high concentrations of AG825 could reduce the drug-induced G(2) arrest that was accompanied by the activation of phosphorylated p34(cdc2), we failed to find any remarkably differential effects of AG825 on drug-induced G(2), arrest and the accompanying phosphorylation status of p34(cdc2) of the high- and and the low-p185(neu) expressing cell lines.	tyrphostin AG825	32-37	cyclin dependent kinase 1	Homo sapiens	141-145
8617791-6	1996	While Cdc25A Cys --&gt; Ser could interact with cyclin A-Cdk2, cyclin B-Cdc2, and cyclin E-Cdk2 strongly, Cdc25B mutant was only found to bind to cyclin A-Cdk2 at significant levels.	Cysteine	13-16	cyclin dependent kinase 1	Homo sapiens	6-10
8603692-0	1996	Characterisation of human cdc2 lysine 33 mutations expressed in the fission yeast Schizosaccharomyces pombe.	Lysine	31-37	cyclin dependent kinase 1	Homo sapiens	26-30
8603692-2	1996	We report the biochemical characterisation of two substitutions of human cdc2 at lysine 33, a residue involved in nucleotide binding, that differently alter the fission yeast cell cycle.	Lysine	81-87	cyclin dependent kinase 1	Homo sapiens	73-77
8822199-6	1996	The tyrosine phosphorylation levels of FAK125, erk1 (mitogen-activated kinase kinase), and cdc-2 were reduced during apoptosis.	Tyrosine	4-12	cyclin dependent kinase 1	Homo sapiens	91-96
8822199-7	1996	FAK125 dephosphorylation was inhibited by orthovanadate, but premature activation (tyrosine dephosphorylation) of cdc-2 was not.	Tyrosine	83-91	cyclin dependent kinase 1	Homo sapiens	114-119
8833397-1	1996	Here we provide experimental evidence that ionizing radiation induces inhibitory tyrosine phosphorylation of the p34cdc2 kinase in human leukemic B-cell precursors.	Tyrosine	81-89	cyclin dependent kinase 1	Homo sapiens	113-120
8833397-2	1996	Herbimycin A markedly reduced tyrosine phosphorylation of p34cdc2 in irradiated leukemic B-cell precursors, thereby preventing radiation-induced cell cycle arrest at the G2-M transition checkpoint.	herbimycin	0-12	cyclin dependent kinase 1	Homo sapiens	58-65
8833397-2	1996	Herbimycin A markedly reduced tyrosine phosphorylation of p34cdc2 in irradiated leukemic B-cell precursors, thereby preventing radiation-induced cell cycle arrest at the G2-M transition checkpoint.	Tyrosine	30-38	cyclin dependent kinase 1	Homo sapiens	58-65
8833397-3	1996	Thus, tyrosine phosphorylation is directly responsible for the inactivation of p34cdc2 in irradiated human leukemic B-cell precursors and activation of protein tyrosine kinases is a proximal and mandatory step in radiation-induced G2-arrest arrest at the G2-M checkpoint.	Tyrosine	6-14	cyclin dependent kinase 1	Homo sapiens	79-86
8833397-6	1996	Thus the signaling pathway leading to inhibitory tyrosine phosphorylation of p34cdc2 and G2-arrest in irradiated human leukemic B-cell precursors functions independent of p49 WEE1 HU and enzymes which augment the tyrosine kinase activity of p49 WEE 1HU.	Tyrosine	49-57	cyclin dependent kinase 1	Homo sapiens	77-84
8549662-7	1996	Parallel to their effect on cell cycle, ASA and indomethacin also reduced the levels of p34cdc2 and p33cdk2, two cyclin-dependent kinases that are important for cell cycle progression.	Aspirin	40-43	cyclin dependent kinase 1	Homo sapiens	88-95
8549662-7	1996	Parallel to their effect on cell cycle, ASA and indomethacin also reduced the levels of p34cdc2 and p33cdk2, two cyclin-dependent kinases that are important for cell cycle progression.	Indomethacin	48-60	cyclin dependent kinase 1	Homo sapiens	88-95
8617791-6	1996	While Cdc25A Cys --&gt; Ser could interact with cyclin A-Cdk2, cyclin B-Cdc2, and cyclin E-Cdk2 strongly, Cdc25B mutant was only found to bind to cyclin A-Cdk2 at significant levels.	Serine	24-27	cyclin dependent kinase 1	Homo sapiens	6-10
8772442-5	1996	Although cdc2 was expressed in the presence of PMA, dephosphorylation of its tyrosine residue was inhibited by PMA.	Tyrosine	77-85	cyclin dependent kinase 1	Homo sapiens	9-13
8956232-3	1996	The most promising experimental results have been obtained with oligonucleotides targeted against genes involved in cell proliferation, such as c-myc, c-myb, Kras, and cdc-2.	Oligonucleotides	64-80	cyclin dependent kinase 1	Homo sapiens	168-173
9552383-2	1996	Here cytokinin stimulates removal of phosphotyrosine from p34cdc2 kinase and concurrently capacity for activation of the kinase by Cdc25 phosphatase declines while activity of the kinase increases and cells enter mitosis.	Phosphotyrosine	37-52	cyclin dependent kinase 1	Homo sapiens	58-65
8548803-3	1995	Furthermore, an evolutionarily conserved cdc2 phosphorylation site (Thr-927) in HsEg5 is phosphorylated specifically during mitosis in HeLa cells and by p34cdc2/cyclin B in vitro.	Threonine	68-71	cyclin dependent kinase 1	Homo sapiens	153-160
7499827-5	1995	Tyrosine phosphorylation of the 34-kDa cdc2 protein kinase was induced transiently after stimulation of the leukemic T cell line, Molt-3, or peripheral blood T cells.	Tyrosine	0-8	cyclin dependent kinase 1	Homo sapiens	39-43
7499827-7	1995	cdc2 kinase activity was constitutive in peripheral blood T cells, and transient inhibition of kinase activity after ICAM-1 stimulation correlated kinetically with phosphorylation of cdc2 on tyrosine.	Tyrosine	191-199	cyclin dependent kinase 1	Homo sapiens	0-4
7499827-7	1995	cdc2 kinase activity was constitutive in peripheral blood T cells, and transient inhibition of kinase activity after ICAM-1 stimulation correlated kinetically with phosphorylation of cdc2 on tyrosine.	Tyrosine	191-199	cyclin dependent kinase 1	Homo sapiens	183-187
8524869-5	1995	Cells rapidly accumulate cyclin B protein and tyrosine-hyperphosphorylated p34cdc2 (cdk1) kinase, indicative of cell cycle arrest at G2 phase.	Tyrosine	46-54	cyclin dependent kinase 1	Homo sapiens	75-82
8524869-5	1995	Cells rapidly accumulate cyclin B protein and tyrosine-hyperphosphorylated p34cdc2 (cdk1) kinase, indicative of cell cycle arrest at G2 phase.	Tyrosine	46-54	cyclin dependent kinase 1	Homo sapiens	84-88
8572241-7	1995	Seventy-two hours after naphthalene treatment a reduction in CDK1 mRNA-positive cells was noted within bronchioles and terminal bronchioles at all locations, with the exception of airway bifurcations.	naphthalene	24-35	cyclin dependent kinase 1	Homo sapiens	61-65
7589260-3	1995	To investigate the mechanism by which TPA arrests melanoma cell growth at the G1/S transition we have examined its effects on the levels of cyclins and cyclin dependent kinases (CDKs) and activation of CDK2 kinase activity.	Tetradecanoylphorbol Acetate	38-41	cyclin dependent kinase 1	Homo sapiens	178-182
7591286-0	1995	Enhanced interaction between tubulin and microtubule-associated protein 2 via inhibition of MAP kinase and CDC2 kinase by paclitaxel.	Paclitaxel	122-132	cyclin dependent kinase 1	Homo sapiens	107-111
7591286-16	1995	Since it has been speculated that p34cdc2 kinase is also a kinase that phosphorylates MAP2, the effect of paclitaxel treatment on the p34cdc2-kinase activity of synchronized PC-14 and PC-9 cells was examined.	Paclitaxel	106-116	cyclin dependent kinase 1	Homo sapiens	134-141
7591286-17	1995	Paclitaxel inhibited p34cdc2-kinase activation at the G2/M phase.	Paclitaxel	0-10	cyclin dependent kinase 1	Homo sapiens	21-28
7591286-18	1995	These results suggest that paclitaxel inhibited MAP kinase and p34cdc2 kinase in vivo indirectly.	Paclitaxel	27-37	cyclin dependent kinase 1	Homo sapiens	63-70
7478536-4	1995	This inhibition coincided with increased tyrosine phosphorylation of cdc2 and was reversed by the cdc25C phosphatase in vitro.	Tyrosine	41-49	cyclin dependent kinase 1	Homo sapiens	69-73
7478536-5	1995	The data indicate that UVB-induced G2 arrest in mammalian cells is mediated by inhibitory tyrosine phosphorylation of cdc2 and acts as a defense mechanism against DNA damage irrespective of the cells" p53 status.	Tyrosine	90-98	cyclin dependent kinase 1	Homo sapiens	118-122
7589260-4	1995	Addition of TPA in G1 blocked the increase in the level of p34cdc2 mRNA, but not of CDK2 mRNA.	Tetradecanoylphorbol Acetate	12-15	cyclin dependent kinase 1	Homo sapiens	59-66
7593219-12	1995	Cells arrested by nocodazole had high levels of active p34cdc2 and greatly reduced levels of p33cdk2 kinase activity.	Nocodazole	18-28	cyclin dependent kinase 1	Homo sapiens	55-62
7495695-3	1995	Proline is on the carboxy terminus of serine 118, which suggests that the serine-proline may be a consensus phosphorylation site motif for either the mitogen-activated protein (MAP) kinase or p34cdc2 kinase.	Proline	0-7	cyclin dependent kinase 1	Homo sapiens	192-199
7495695-3	1995	Proline is on the carboxy terminus of serine 118, which suggests that the serine-proline may be a consensus phosphorylation site motif for either the mitogen-activated protein (MAP) kinase or p34cdc2 kinase.	Serine	38-44	cyclin dependent kinase 1	Homo sapiens	192-199
7495695-3	1995	Proline is on the carboxy terminus of serine 118, which suggests that the serine-proline may be a consensus phosphorylation site motif for either the mitogen-activated protein (MAP) kinase or p34cdc2 kinase.	Serine	74-80	cyclin dependent kinase 1	Homo sapiens	192-199
7495695-3	1995	Proline is on the carboxy terminus of serine 118, which suggests that the serine-proline may be a consensus phosphorylation site motif for either the mitogen-activated protein (MAP) kinase or p34cdc2 kinase.	Proline	81-88	cyclin dependent kinase 1	Homo sapiens	192-199
7578274-0	1995	The protein kinase from mitotic human cells that phosphorylates Ser-209 on the casein kinase II beta-subunit is p34cdc2.	Serine	64-67	cyclin dependent kinase 1	Homo sapiens	112-119
7474080-5	1995	In cycling cells, progression from G2 to M phase is driven by activation of the p34cdc2/cyclin B complex, an event caused, in part, by dephosphorylation of two regulatory amino acids of p34cdc2 (Thr-14 and Tyr-15).	Threonine	195-198	cyclin dependent kinase 1	Homo sapiens	80-87
7474080-5	1995	In cycling cells, progression from G2 to M phase is driven by activation of the p34cdc2/cyclin B complex, an event caused, in part, by dephosphorylation of two regulatory amino acids of p34cdc2 (Thr-14 and Tyr-15).	Threonine	195-198	cyclin dependent kinase 1	Homo sapiens	186-193
7474080-5	1995	In cycling cells, progression from G2 to M phase is driven by activation of the p34cdc2/cyclin B complex, an event caused, in part, by dephosphorylation of two regulatory amino acids of p34cdc2 (Thr-14 and Tyr-15).	Tyrosine	206-209	cyclin dependent kinase 1	Homo sapiens	80-87
7474080-5	1995	In cycling cells, progression from G2 to M phase is driven by activation of the p34cdc2/cyclin B complex, an event caused, in part, by dephosphorylation of two regulatory amino acids of p34cdc2 (Thr-14 and Tyr-15).	Tyrosine	206-209	cyclin dependent kinase 1	Homo sapiens	186-193
7578274-8	1995	Furthermore, depletion of the Ser-209 kinase activity with p13suc1-Sepharose and anti-p34cdc2 antiserum demonstrated conclusively that the isolated Ser-209 kinase is p34cdc2.	Sepharose	67-76	cyclin dependent kinase 1	Homo sapiens	166-173
7578274-9	1995	These studies provide strong biochemical evidence that p34cdc2 is the enzyme that phosphorylates Ser-209 on the beta-subunit of CKII in mitotic cells.	Serine	97-100	cyclin dependent kinase 1	Homo sapiens	55-62
7578274-10	1995	In addition, these results indicate that the Ser-209 peptide can be utilized as a specific reagent for the assay of p34cdc2 activity in mitotic extracts, since no other Ser-209 peptide kinase activities were detected.	Serine	45-48	cyclin dependent kinase 1	Homo sapiens	116-123
7568188-2	1995	Biochemical studies carried out in vitro with recombinant protein demonstrated that WEE1Hu encodes a tyrosine kinase of approximately 49 kDa that phosphorylates p34cdc2 on Tyr-15 [Parker, L. L. &amp; Piwnica-Worms, H. (1992) Science 257, 1955-1957].	Tyrosine	172-175	cyclin dependent kinase 1	Homo sapiens	161-168
7568188-6	1995	Immunoprecipitates of p95 phosphorylated p34cdc2 on Tyr-15, indicating that p95 is functionally related to p49WEEIHu, and mapping studies demonstrated that p95 is structurally related to p49WEE1Hu.	Tyrosine	52-55	cyclin dependent kinase 1	Homo sapiens	41-48
7574801-3	1995	Our data suggested that arresting cells in the G2-phase of the cell cycle by cisplatin might be regulated by dephosphorylation of cdc2 kinase.	Cisplatin	77-86	cyclin dependent kinase 1	Homo sapiens	130-134
7574801-4	1995	Butyrolactone I inhibits both cdc2 and CDK2 kinase in the cell-free system.	butyrolactone I	0-15	cyclin dependent kinase 1	Homo sapiens	30-34
7574801-6	1995	Suramin inhibits cdc2 kinase.	Suramin	0-7	cyclin dependent kinase 1	Homo sapiens	17-21
7574801-7	1995	UCN-01, a protein kinase-C inhibitor, also inhibits both cdc2 and CDK2 kinase.	7-hydroxystaurosporine	0-6	cyclin dependent kinase 1	Homo sapiens	57-61
7559776-3	1995	When cleavage furrow formation is blocked at 10 microM DCB, cells return to interphase by the criteria of reformation of nuclei with lamin borders, degradation of the cyclin B component of p34cdc2 kinase, and loss of mitosis specific MPM-2 antigens.	dihydrocytochalasin B	55-58	cyclin dependent kinase 1	Homo sapiens	189-196
7566979-5	1995	Induction of both terminal differentiation and reversible differentiation (MEZ treatment) results in a temporal decrease in DNA synthesis and the percentage of cells in S phase and a decrease in the expression of cell cycle and growth regulated genes, including cdc2, cyclin A, cyclin B, histone H1, histone H4, nm23-H1, p53 and c-myc.	mezerein	75-78	cyclin dependent kinase 1	Homo sapiens	262-266
7673335-7	1995	Mutation analysis indicated that the serine residue at the fourth position of the E1 enzyme was a phosphorylation site of Cdc2 kinase.	Serine	37-43	cyclin dependent kinase 1	Homo sapiens	122-126
7662974-3	1995	DFO (10 mumol/L) inhibited induction of transcription of the cdc2 gene, but had no effect on accumulation of cdk2, cdk4, or interleukin (IL)-2-transcripts.	Deferoxamine	0-3	cyclin dependent kinase 1	Homo sapiens	61-65
7557404-5	1995	The three kinases have conserved Tyr and Thr residues that are sites of phosphorylation in cdc2 and are important for regulating kinase activity.	Tyrosine	33-36	cyclin dependent kinase 1	Homo sapiens	91-95
7557404-5	1995	The three kinases have conserved Tyr and Thr residues that are sites of phosphorylation in cdc2 and are important for regulating kinase activity.	Threonine	41-44	cyclin dependent kinase 1	Homo sapiens	91-95
8547221-0	1995	Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2.	7-hydroxystaurosporine	13-35	cyclin dependent kinase 1	Homo sapiens	89-121
7622588-0	1995	Selective induction of cell cycle regulatory genes cdk1 (p34cdc2), cyclins A/B, and the tumor suppressor gene Rb in transformed cells by okadaic acid.	Okadaic Acid	137-149	cyclin dependent kinase 1	Homo sapiens	51-55
7622588-0	1995	Selective induction of cell cycle regulatory genes cdk1 (p34cdc2), cyclins A/B, and the tumor suppressor gene Rb in transformed cells by okadaic acid.	Okadaic Acid	137-149	cyclin dependent kinase 1	Homo sapiens	57-64
7622588-3	1995	We have investigated levels of mRNA encoding cdk1 (p34cdc2), cyclin A, cyclin B, Rb, GAPDH, c-myc, and histone H4 genes for sensitivity to okadaic acid in HeLa cells to determine if transformation altered their regulation.	Okadaic Acid	139-151	cyclin dependent kinase 1	Homo sapiens	45-49
7622588-3	1995	We have investigated levels of mRNA encoding cdk1 (p34cdc2), cyclin A, cyclin B, Rb, GAPDH, c-myc, and histone H4 genes for sensitivity to okadaic acid in HeLa cells to determine if transformation altered their regulation.	Okadaic Acid	139-151	cyclin dependent kinase 1	Homo sapiens	51-58
7622588-5	1995	When starved cells were subsequently exposed to 19 nM okadaic acid or refed 10% serum, mRNA levels of cyclin A, cyclin B, cdk1, and Rb dramatically increased while mRNA levels for c-myc and GAPDH were largely unaffected.	Okadaic Acid	54-66	cyclin dependent kinase 1	Homo sapiens	122-126
7592773-7	1995	Four residues within this domain, Thr-344, Thr-360, Ser-362, and Ser-370, conform to the minimal consensus sequence for p34cdc2 phosphorylation.	Threonine	34-37	cyclin dependent kinase 1	Homo sapiens	120-127
7760824-4	1995	Intriguingly, TPA-mediated repression of the cdc2 promoter was independent of the transcription factor E2F, distinguishing this pathway from mechanisms responsible for repression of cdc2 transcription in response to serum starvation.	Tetradecanoylphorbol Acetate	14-17	cyclin dependent kinase 1	Homo sapiens	45-49
7760824-4	1995	Intriguingly, TPA-mediated repression of the cdc2 promoter was independent of the transcription factor E2F, distinguishing this pathway from mechanisms responsible for repression of cdc2 transcription in response to serum starvation.	Tetradecanoylphorbol Acetate	14-17	cyclin dependent kinase 1	Homo sapiens	182-186
7760824-7	1995	Analysis of THP1 nuclear proteins revealed a 55-kDa protein that was induced by TPA and interacted with the cdc2 promoter in an R-box-dependent manner.	Tetradecanoylphorbol Acetate	80-83	cyclin dependent kinase 1	Homo sapiens	108-112
7774574-1	1995	WEE1 kinase negatively regulates entry into mitosis by catalyzing the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase.	Tyrosine	81-89	cyclin dependent kinase 1	Homo sapiens	109-113
7786802-6	1995	Cell proliferative capacity was well correlated with the amount of cdc2 mRNA transcripts, i.e. 3H-thymidine incorporation was highest in cases with cdc2 mRNA over-expression and was significantly higher in cdc2-positive cases than in cdc2-negative cases.	Tritium	95-97	cyclin dependent kinase 1	Homo sapiens	67-71
7786802-6	1995	Cell proliferative capacity was well correlated with the amount of cdc2 mRNA transcripts, i.e. 3H-thymidine incorporation was highest in cases with cdc2 mRNA over-expression and was significantly higher in cdc2-positive cases than in cdc2-negative cases.	Tritium	95-97	cyclin dependent kinase 1	Homo sapiens	148-152
7786802-6	1995	Cell proliferative capacity was well correlated with the amount of cdc2 mRNA transcripts, i.e. 3H-thymidine incorporation was highest in cases with cdc2 mRNA over-expression and was significantly higher in cdc2-positive cases than in cdc2-negative cases.	Tritium	95-97	cyclin dependent kinase 1	Homo sapiens	148-152
7786802-6	1995	Cell proliferative capacity was well correlated with the amount of cdc2 mRNA transcripts, i.e. 3H-thymidine incorporation was highest in cases with cdc2 mRNA over-expression and was significantly higher in cdc2-positive cases than in cdc2-negative cases.	Tritium	95-97	cyclin dependent kinase 1	Homo sapiens	148-152
7786802-6	1995	Cell proliferative capacity was well correlated with the amount of cdc2 mRNA transcripts, i.e. 3H-thymidine incorporation was highest in cases with cdc2 mRNA over-expression and was significantly higher in cdc2-positive cases than in cdc2-negative cases.	Thymidine	98-107	cyclin dependent kinase 1	Homo sapiens	67-71
7786802-6	1995	Cell proliferative capacity was well correlated with the amount of cdc2 mRNA transcripts, i.e. 3H-thymidine incorporation was highest in cases with cdc2 mRNA over-expression and was significantly higher in cdc2-positive cases than in cdc2-negative cases.	Thymidine	98-107	cyclin dependent kinase 1	Homo sapiens	148-152
7786802-6	1995	Cell proliferative capacity was well correlated with the amount of cdc2 mRNA transcripts, i.e. 3H-thymidine incorporation was highest in cases with cdc2 mRNA over-expression and was significantly higher in cdc2-positive cases than in cdc2-negative cases.	Thymidine	98-107	cyclin dependent kinase 1	Homo sapiens	148-152
7786802-6	1995	Cell proliferative capacity was well correlated with the amount of cdc2 mRNA transcripts, i.e. 3H-thymidine incorporation was highest in cases with cdc2 mRNA over-expression and was significantly higher in cdc2-positive cases than in cdc2-negative cases.	Thymidine	98-107	cyclin dependent kinase 1	Homo sapiens	148-152
7728771-1	1995	The cell cycle inhibitor mimosine was used to examine the activation of the p34cdc2 protein kinase in S phase of the cell cycle.	Mimosine	25-33	cyclin dependent kinase 1	Homo sapiens	76-83
7592773-7	1995	Four residues within this domain, Thr-344, Thr-360, Ser-362, and Ser-370, conform to the minimal consensus sequence for p34cdc2 phosphorylation.	Threonine	43-46	cyclin dependent kinase 1	Homo sapiens	120-127
7592773-7	1995	Four residues within this domain, Thr-344, Thr-360, Ser-362, and Ser-370, conform to the minimal consensus sequence for p34cdc2 phosphorylation.	Serine	52-55	cyclin dependent kinase 1	Homo sapiens	120-127
7592773-7	1995	Four residues within this domain, Thr-344, Thr-360, Ser-362, and Ser-370, conform to the minimal consensus sequence for p34cdc2 phosphorylation.	Serine	65-68	cyclin dependent kinase 1	Homo sapiens	120-127
7743995-1	1995	In higher eukaryotes, the cyclin-dependent kinases (CDKs) are negatively regulated by phosphorylation on threonine 14 (T14) and tyrosine 15 (Y15).	Threonine	105-114	cyclin dependent kinase 1	Homo sapiens	52-56
7743995-1	1995	In higher eukaryotes, the cyclin-dependent kinases (CDKs) are negatively regulated by phosphorylation on threonine 14 (T14) and tyrosine 15 (Y15).	Tyrosine	128-136	cyclin dependent kinase 1	Homo sapiens	52-56
7712486-3	1995	This G2 delay was strong by 1 h following exposure to IR, maximal by 2 h, and was accompanied by an accumulation of tyrosine-phosphorylated p34CDC2 molecules.	Tyrosine	116-124	cyclin dependent kinase 1	Homo sapiens	140-147
7718595-0	1995	1-beta-D-arabinofuranosylcytosine activates tyrosine phosphorylation of p34cdc2 and its association with the Src-like p56/p53lyn kinase in human myeloid leukemia cells.	Cytarabine	0-33	cyclin dependent kinase 1	Homo sapiens	72-79
7718595-0	1995	1-beta-D-arabinofuranosylcytosine activates tyrosine phosphorylation of p34cdc2 and its association with the Src-like p56/p53lyn kinase in human myeloid leukemia cells.	Tyrosine	44-52	cyclin dependent kinase 1	Homo sapiens	72-79
7592534-3	1995	Most of this phosphorylation and electrophoretic mobility shift, that occurred in the brain extract incubated with ATP, were inhibited by butyrolactone I, a specific inhibitor of cdc2 kinase and cdk5.	Adenosine Triphosphate	115-118	cyclin dependent kinase 1	Homo sapiens	179-183
7592534-3	1995	Most of this phosphorylation and electrophoretic mobility shift, that occurred in the brain extract incubated with ATP, were inhibited by butyrolactone I, a specific inhibitor of cdc2 kinase and cdk5.	butyrolactone I	138-153	cyclin dependent kinase 1	Homo sapiens	179-183
7877973-5	1995	In addition, IL-6 antisense oligonucleotides abolished PDGF-induced transcription of the genes coding for the cell division cycle 2-related protein (CDC2) and proliferating cell nuclear antigen (PCNA), both of which are regulated in a cell cycle-dependent manner.	Oligonucleotides	28-44	cyclin dependent kinase 1	Homo sapiens	110-147
7877973-5	1995	In addition, IL-6 antisense oligonucleotides abolished PDGF-induced transcription of the genes coding for the cell division cycle 2-related protein (CDC2) and proliferating cell nuclear antigen (PCNA), both of which are regulated in a cell cycle-dependent manner.	Oligonucleotides	28-44	cyclin dependent kinase 1	Homo sapiens	149-153
7864866-7	1995	On the other hand cdc2-cyclin B introduced up to 0.8 mol/mol phosphate into isolated I2 and four phosphopeptides were obtained.	Phosphates	61-70	cyclin dependent kinase 1	Homo sapiens	18-22
7823958-6	1995	This activation-dependent induction of H1 kinase activity in T cells is associated with a decrease in the phosphotyrosine content of p34cdc2.	Phosphotyrosine	106-121	cyclin dependent kinase 1	Homo sapiens	133-140
7530044-0	1995	1-beta-D-arabinofuranosylcytosine activates tyrosine phosphorylation of p34cdc2 and its association with the Src-like p56/p53lyn kinase in human myeloid leukemia cells.	Cytarabine	0-33	cyclin dependent kinase 1	Homo sapiens	72-79
7530044-0	1995	1-beta-D-arabinofuranosylcytosine activates tyrosine phosphorylation of p34cdc2 and its association with the Src-like p56/p53lyn kinase in human myeloid leukemia cells.	Tyrosine	44-52	cyclin dependent kinase 1	Homo sapiens	72-79
7530044-3	1995	The results of immunoprecipitation studies demonstrate that HL-60 cells respond to ara-C with tyrosine phosphorylation of the cell cycle regulatory protein p34cdc2 and a decrease in the activity of this kinase.	Cytarabine	83-88	cyclin dependent kinase 1	Homo sapiens	156-163
7530044-3	1995	The results of immunoprecipitation studies demonstrate that HL-60 cells respond to ara-C with tyrosine phosphorylation of the cell cycle regulatory protein p34cdc2 and a decrease in the activity of this kinase.	Tyrosine	94-102	cyclin dependent kinase 1	Homo sapiens	156-163
7530044-5	1995	Coimmunoprecipitations with anti-p34cdc2 support binding of this protein to the Src-like p56/p53lyn tyrosine kinase in ara-C-treated, but not untreated, cells.	Cytarabine	119-124	cyclin dependent kinase 1	Homo sapiens	33-40
7530044-7	1995	Studies with a glutathione S-transferase-Lyn fusion protein confirm interaction of p34cdc2 and p56/p53lyn in lysates of ara-C-treated cells.	Glutathione	15-26	cyclin dependent kinase 1	Homo sapiens	83-90
7530044-7	1995	Studies with a glutathione S-transferase-Lyn fusion protein confirm interaction of p34cdc2 and p56/p53lyn in lysates of ara-C-treated cells.	Cytarabine	120-125	cyclin dependent kinase 1	Homo sapiens	83-90
7530044-8	1995	Moreover, we demonstrate that (1) p56/p53lyn phosphorylates Tyr-15 of p34cdc2 in vitro and (2) phosphorylation of p34cdc2 by p56/p53lyn inhibits p34cdc2 activity.	Tyrosine	60-63	cyclin dependent kinase 1	Homo sapiens	70-77
7530044-8	1995	Moreover, we demonstrate that (1) p56/p53lyn phosphorylates Tyr-15 of p34cdc2 in vitro and (2) phosphorylation of p34cdc2 by p56/p53lyn inhibits p34cdc2 activity.	Tyrosine	60-63	cyclin dependent kinase 1	Homo sapiens	114-121
7530044-8	1995	Moreover, we demonstrate that (1) p56/p53lyn phosphorylates Tyr-15 of p34cdc2 in vitro and (2) phosphorylation of p34cdc2 by p56/p53lyn inhibits p34cdc2 activity.	Tyrosine	60-63	cyclin dependent kinase 1	Homo sapiens	114-121
7530044-9	1995	These findings indicate that the cellular response to ara-C includes activation of p56/p53lyn and that association of p56/p53lyn with p34cdc2 may contribute to regulation of the cell cycle progression in ara-C-treated cells.	Cytarabine	204-209	cyclin dependent kinase 1	Homo sapiens	134-141
7812949-2	1995	We found that cyclin B1/Cdc2 kinase activity transiently increases within 30 min after camptothecin treatment.	Camptothecin	87-99	cyclin dependent kinase 1	Homo sapiens	24-28
7812949-3	1995	This increase is followed by a rapid inactivation of the cyclin B1/Cdc2 kinase that is associated with Cdc2 tyrosine phosphorylation without any change in Cdc2 or cyclin B1 protein levels.	Tyrosine	108-116	cyclin dependent kinase 1	Homo sapiens	67-71
7812949-3	1995	This increase is followed by a rapid inactivation of the cyclin B1/Cdc2 kinase that is associated with Cdc2 tyrosine phosphorylation without any change in Cdc2 or cyclin B1 protein levels.	Tyrosine	108-116	cyclin dependent kinase 1	Homo sapiens	103-107
7812949-3	1995	This increase is followed by a rapid inactivation of the cyclin B1/Cdc2 kinase that is associated with Cdc2 tyrosine phosphorylation without any change in Cdc2 or cyclin B1 protein levels.	Tyrosine	108-116	cyclin dependent kinase 1	Homo sapiens	103-107
7812949-4	1995	The DNA polymerase inhibitor aphidicolin abrogates camptothecin-induced changes in cyclin B1/Cdc2 kinase activity, indicating that DNA replication-induced DNA damage is essential for both Cdc2 alterations and apoptosis activation.	Aphidicolin	29-40	cyclin dependent kinase 1	Homo sapiens	93-97
7812949-4	1995	The DNA polymerase inhibitor aphidicolin abrogates camptothecin-induced changes in cyclin B1/Cdc2 kinase activity, indicating that DNA replication-induced DNA damage is essential for both Cdc2 alterations and apoptosis activation.	Aphidicolin	29-40	cyclin dependent kinase 1	Homo sapiens	188-192
7812949-4	1995	The DNA polymerase inhibitor aphidicolin abrogates camptothecin-induced changes in cyclin B1/Cdc2 kinase activity, indicating that DNA replication-induced DNA damage is essential for both Cdc2 alterations and apoptosis activation.	Camptothecin	51-63	cyclin dependent kinase 1	Homo sapiens	93-97
7812949-4	1995	The DNA polymerase inhibitor aphidicolin abrogates camptothecin-induced changes in cyclin B1/Cdc2 kinase activity, indicating that DNA replication-induced DNA damage is essential for both Cdc2 alterations and apoptosis activation.	Camptothecin	51-63	cyclin dependent kinase 1	Homo sapiens	188-192
7812949-6	1995	The same transient activation and subsequent inactivation of cyclin B1/Cdc2 kinase were observed after DNA damage by etoposide or bis-(2-chloroethyl)methylamine hydrochloride.	Etoposide	117-126	cyclin dependent kinase 1	Homo sapiens	71-75
7812949-6	1995	The same transient activation and subsequent inactivation of cyclin B1/Cdc2 kinase were observed after DNA damage by etoposide or bis-(2-chloroethyl)methylamine hydrochloride.	Mechlorethamine	130-174	cyclin dependent kinase 1	Homo sapiens	71-75
8720436-2	1995	The association of the cAMP-dependent protein kinase type II and the mitotic kinase p34cdc2 with centrosomes from human lymphoblast cells has previously been shown (Keryer et al, 1993, Exp Cell Res 204, 230-240; Bailly et al, 1989, EMBO J 8, 3985-3995).	Cyclic AMP	23-27	cyclin dependent kinase 1	Homo sapiens	84-91
7728771-2	1995	Addition of mimosine to cycling epithelial cells halted cell cycle traverse in S phase, coincident with an inhibition of p34cdc2 histone H1 kinase activity.	Mimosine	12-20	cyclin dependent kinase 1	Homo sapiens	121-128
7799941-1	1995	The cyclin-dependent protein kinases (CDKs) are activated by association with cyclins and by phosphorylation at a conserved threonine residue by the CDK-activating kinase (CAK).	Threonine	124-133	cyclin dependent kinase 1	Homo sapiens	38-42
7876309-10	1995	Incubation of a ternary complex of p34cdc2, cyclin B, and the COOH-terminal domain of MAP4, PA4, with ATP resulted in intracomplex phosphorylation of PA4.	Adenosine Triphosphate	102-105	cyclin dependent kinase 1	Homo sapiens	35-42
7876309-10	1995	Incubation of a ternary complex of p34cdc2, cyclin B, and the COOH-terminal domain of MAP4, PA4, with ATP resulted in intracomplex phosphorylation of PA4.	pa4	92-95	cyclin dependent kinase 1	Homo sapiens	35-42
7814450-5	1995	The use of antiphosphotyrosine antibodies, however, showed that p34cdc2 from cultures treated with EGF was more intensely stained than that of control cells, indicating that EGF treatment prevents the tyrosine dephosphorylation which is required for expression of the protein kinase activity of the complex.	Tyrosine	22-30	cyclin dependent kinase 1	Homo sapiens	64-71
7799941-4	1995	One complex (CDC2-cyclin A) forms with high affinity only after CAK-mediated phosphorylation of CDC2 at the activating threonine residue.	Threonine	119-128	cyclin dependent kinase 1	Homo sapiens	13-17
7799941-4	1995	One complex (CDC2-cyclin A) forms with high affinity only after CAK-mediated phosphorylation of CDC2 at the activating threonine residue.	Threonine	119-128	cyclin dependent kinase 1	Homo sapiens	96-100
8657628-2	1995	Cyclin-dependent kinases (cdks) is a family of serine-threonine kinases whose principal role is the promotion of the cell transition through the regulatory points of the cell cycle (G1 and G2/M).	Serine	47-53	cyclin dependent kinase 1	Homo sapiens	26-30
9552363-5	1995	Overexpression of NIMA induces germinal vesicle breakdown in Xenopus oocytes and promotes premature entry into mitosis in all eukaryotic cells examined, whereas dominant-negative mutant NIMA causes a specific G2 arrest in Aspergillus nidulans and human cells, as is the case for CDC2.	nima	18-22	cyclin dependent kinase 1	Homo sapiens	279-283
9552365-1	1995	Activation of the cyclin B-cdc2 kinase mitotic inducer involves dephosphorylation of two inhibitory residues, tyrosine 15 and threonine 14, cdc25 is the specific phosphatase that directly dephosphorylates and activates the cdc2 kinase, cdc25 activity is regulated by phosphorylation.	Tyrosine	110-118	cyclin dependent kinase 1	Homo sapiens	27-31
9552365-1	1995	Activation of the cyclin B-cdc2 kinase mitotic inducer involves dephosphorylation of two inhibitory residues, tyrosine 15 and threonine 14, cdc25 is the specific phosphatase that directly dephosphorylates and activates the cdc2 kinase, cdc25 activity is regulated by phosphorylation.	Tyrosine	110-118	cyclin dependent kinase 1	Homo sapiens	140-144
9552365-1	1995	Activation of the cyclin B-cdc2 kinase mitotic inducer involves dephosphorylation of two inhibitory residues, tyrosine 15 and threonine 14, cdc25 is the specific phosphatase that directly dephosphorylates and activates the cdc2 kinase, cdc25 activity is regulated by phosphorylation.	Threonine	126-135	cyclin dependent kinase 1	Homo sapiens	27-31
9552365-1	1995	Activation of the cyclin B-cdc2 kinase mitotic inducer involves dephosphorylation of two inhibitory residues, tyrosine 15 and threonine 14, cdc25 is the specific phosphatase that directly dephosphorylates and activates the cdc2 kinase, cdc25 activity is regulated by phosphorylation.	Threonine	126-135	cyclin dependent kinase 1	Homo sapiens	140-144
7813446-1	1994	Wee1 protein kinase regulates the length of G2 phase by carrying out the inhibitory tyrosyl phosphorylation of Cdc2-cyclin B kinase.	cyclo(tyrosyl-tyrosyl)	84-91	cyclin dependent kinase 1	Homo sapiens	111-115
7986086-2	1994	Replacement of the proline residue by any of the other 19 amino acids or D-proline drastically reduces or abolishes phosphorylation by CDC2.	Proline	19-26	cyclin dependent kinase 1	Homo sapiens	135-139
7986086-2	1994	Replacement of the proline residue by any of the other 19 amino acids or D-proline drastically reduces or abolishes phosphorylation by CDC2.	D-proline	73-82	cyclin dependent kinase 1	Homo sapiens	135-139
7528141-3	1994	Comparison of the phosphorylation kinetics with those found for the tyrosine residues on a peptide comprising the regulatory tyrosine phosphorylation site of cdc2 points to the role of the primary sequence context of the phosphate acceptor.	Tyrosine	68-76	cyclin dependent kinase 1	Homo sapiens	158-162
7528141-3	1994	Comparison of the phosphorylation kinetics with those found for the tyrosine residues on a peptide comprising the regulatory tyrosine phosphorylation site of cdc2 points to the role of the primary sequence context of the phosphate acceptor.	Tyrosine	125-133	cyclin dependent kinase 1	Homo sapiens	158-162
7528141-3	1994	Comparison of the phosphorylation kinetics with those found for the tyrosine residues on a peptide comprising the regulatory tyrosine phosphorylation site of cdc2 points to the role of the primary sequence context of the phosphate acceptor.	Phosphates	221-230	cyclin dependent kinase 1	Homo sapiens	158-162
8012959-6	1994	AGM-1470 inhibits growth factor-induced activation of candidate RB kinases cdc2 and cdk2 but fails to inhibit them directly in vitro.	O-(Chloroacetylcarbamoyl)fumagillol	0-8	cyclin dependent kinase 1	Homo sapiens	75-79
7961734-1	1994	Cdc25 protein phosphatase dephosphorylates tyrosine 15 of Cdc2, thereby activating Cdc2/cyclin B kinase, which then brings about mitosis.	Tyrosine	43-51	cyclin dependent kinase 1	Homo sapiens	0-4
7961734-1	1994	Cdc25 protein phosphatase dephosphorylates tyrosine 15 of Cdc2, thereby activating Cdc2/cyclin B kinase, which then brings about mitosis.	Tyrosine	43-51	cyclin dependent kinase 1	Homo sapiens	58-62
7961734-7	1994	Rescue of cdc25-22 by overproduction of Stp1 protein is probably due to an ability of Stp1 to dephosphorylate tyrosine 15 of Cdc2.	Tyrosine	110-118	cyclin dependent kinase 1	Homo sapiens	125-129
7962060-7	1994	2-AP-induced inactivation of p34cdc2 and mitotic exit depend on the assembly state of microtubules.	2-ap	0-4	cyclin dependent kinase 1	Homo sapiens	29-36
7935441-3	1994	This step is catalyzed by a cdk-activating kinase (CAK) functionally analogous to the enzyme which phosphorylates cdc2 and cdk2 at Thr-161/160.	Threonine	131-134	cyclin dependent kinase 1	Homo sapiens	114-118
21607529-1	1994	Phosphorylation of human p34(cdc2) at Thr 161 seems to be necessary for its catalytic activity.	Threonine	38-41	cyclin dependent kinase 1	Homo sapiens	29-33
7929427-6	1994	Moreover, phosphorylation of Csk-treated pp60c-src by Cdc2 also facilitated complete reactivation by the protein-tyrosine phosphatase CD45 or by a synthetic phosphopeptide corresponding to the C-terminal, regulatory phosphorylation site (Tyr-527).	Tyrosine	238-241	cyclin dependent kinase 1	Homo sapiens	54-58
7929427-7	1994	These data indicate that the Src homology 2 domain of Csk-phosphorylated pp60c-src was more accessible for intermolecular interactions and that Tyr-527 was more readily dephosphorylated after treatment with Cdc2.	Tyrosine	144-147	cyclin dependent kinase 1	Homo sapiens	207-211
7944411-2	1994	In this paper we report on the enzymatic activation of p34cdc2/p58Cyclin A PDPK by a protein kinase present in human cells that targets threonine-161 of Cdc2.	Threonine	136-145	cyclin dependent kinase 1	Homo sapiens	55-62
7944411-2	1994	In this paper we report on the enzymatic activation of p34cdc2/p58Cyclin A PDPK by a protein kinase present in human cells that targets threonine-161 of Cdc2.	Threonine	136-145	cyclin dependent kinase 1	Homo sapiens	153-157
7848905-0	1994	Activation of p34cdc2 coincident with taxol-induced apoptosis.	Paclitaxel	38-43	cyclin dependent kinase 1	Homo sapiens	14-21
7848906-0	1994	Release from G0/G1 arrest induced by dimethyl sulfoxide in human lymphoid cells: regulation of synthesis and activation of the p33cdk2 and p34cdc2 kinases.	Dimethyl Sulfoxide	37-55	cyclin dependent kinase 1	Homo sapiens	139-146
7929589-1	1994	The activity of cyclin-dependent kinases (cdks) depends on the phosphorylation of a residue corresponding to threonine 161 in human p34cdc2.	Threonine	109-118	cyclin dependent kinase 1	Homo sapiens	42-46
7929589-1	1994	The activity of cyclin-dependent kinases (cdks) depends on the phosphorylation of a residue corresponding to threonine 161 in human p34cdc2.	Threonine	109-118	cyclin dependent kinase 1	Homo sapiens	132-139
7929589-12	1994	It suggests that the phosphorylation state of threonine 161 in p34cdc2 (and the corresponding residue in other cdks) may be regulated primarily by the availability of the cdk/cyclin substrates, and by phosphatase(s).	Threonine	46-55	cyclin dependent kinase 1	Homo sapiens	63-70
7929589-12	1994	It suggests that the phosphorylation state of threonine 161 in p34cdc2 (and the corresponding residue in other cdks) may be regulated primarily by the availability of the cdk/cyclin substrates, and by phosphatase(s).	Threonine	46-55	cyclin dependent kinase 1	Homo sapiens	111-115
8084605-8	1994	Coimmunoprecipitation studies further confirmed the association of p56/p53lyn and p34cdc2 in MMC-treated cells.	Mitomycin	93-96	cyclin dependent kinase 1	Homo sapiens	82-89
8084605-9	1994	We also demonstrate that p34cdc2 undergoes increased phosphorylation on tyrosine following MMC exposure and that p56/p53lyn phosphorylates the Tyr-15 site of p34cdc2 in vitro.	Tyrosine	72-80	cyclin dependent kinase 1	Homo sapiens	25-32
8084605-9	1994	We also demonstrate that p34cdc2 undergoes increased phosphorylation on tyrosine following MMC exposure and that p56/p53lyn phosphorylates the Tyr-15 site of p34cdc2 in vitro.	Mitomycin	91-94	cyclin dependent kinase 1	Homo sapiens	25-32
8084605-9	1994	We also demonstrate that p34cdc2 undergoes increased phosphorylation on tyrosine following MMC exposure and that p56/p53lyn phosphorylates the Tyr-15 site of p34cdc2 in vitro.	Tyrosine	143-146	cyclin dependent kinase 1	Homo sapiens	25-32
8084605-9	1994	We also demonstrate that p34cdc2 undergoes increased phosphorylation on tyrosine following MMC exposure and that p56/p53lyn phosphorylates the Tyr-15 site of p34cdc2 in vitro.	Tyrosine	143-146	cyclin dependent kinase 1	Homo sapiens	158-165
7929076-5	1994	Mutant RPA with both consensus p34cdc2 sites converted to alanine was not phosphorylated by purified p34cdc2 kinase.	Alanine	58-65	cyclin dependent kinase 1	Homo sapiens	31-38
7945307-0	1994	Effect of suramin on p34cdc2 kinase in vitro and in extracts from human H69 cells: evidence for a double mechanism of action.	Suramin	10-17	cyclin dependent kinase 1	Homo sapiens	21-28
7945307-1	1994	We examined the effect of suramin, an anticancer agent and a functional analog of naturally occuring glycosaminoglycans, on p34cdc2 kinase.	Suramin	26-33	cyclin dependent kinase 1	Homo sapiens	124-131
7945307-1	1994	We examined the effect of suramin, an anticancer agent and a functional analog of naturally occuring glycosaminoglycans, on p34cdc2 kinase.	Glycosaminoglycans	101-119	cyclin dependent kinase 1	Homo sapiens	124-131
7945307-2	1994	We find that suramin strongly inhibits the catalytic activity of purified p34cdc2 kinase (IC50 approximately 4 microM), whereas it only weakly inhibits the p13-agarose precipitated kinase activity from nuclear and cytoplasmic extracts of the asynchronous H69 human small cell lung cancer cells.	Suramin	13-20	cyclin dependent kinase 1	Homo sapiens	74-81
7945307-3	1994	We also find that the tyrosine phosphorylation of p34cdc2 kinase in the nuclear extract is increased about twice when the extracts are preincubated with 50 microM of suramin prior to the p13-agarose precipitation.	Tyrosine	22-30	cyclin dependent kinase 1	Homo sapiens	50-57
7945307-3	1994	We also find that the tyrosine phosphorylation of p34cdc2 kinase in the nuclear extract is increased about twice when the extracts are preincubated with 50 microM of suramin prior to the p13-agarose precipitation.	Suramin	166-173	cyclin dependent kinase 1	Homo sapiens	50-57
7945307-3	1994	We also find that the tyrosine phosphorylation of p34cdc2 kinase in the nuclear extract is increased about twice when the extracts are preincubated with 50 microM of suramin prior to the p13-agarose precipitation.	Sepharose	191-198	cyclin dependent kinase 1	Homo sapiens	50-57
7945307-4	1994	We propose that this increase might result from the inhibitory effect of suramin towards p34cdc2-specific tyrosine phosphatases.	Suramin	73-80	cyclin dependent kinase 1	Homo sapiens	89-96
7945307-5	1994	These results suggest both a direct and an indirect effect of suramin on p34cdc2 kinase.	Suramin	62-69	cyclin dependent kinase 1	Homo sapiens	73-80
7945307-7	1994	Therefore, glycosaminoglycans might be physiological regulators of p34cdc2 kinase in vivo.	Glycosaminoglycans	11-29	cyclin dependent kinase 1	Homo sapiens	67-74
7925980-5	1994	We propose here that a CDC2-like proline-directed kinase regulates myogenin activity through its phosphorylation.	Proline	33-40	cyclin dependent kinase 1	Homo sapiens	23-27
7937793-7	1994	Cells arrested in G2 phase following nitrogen mustard treatment or cells arrested in S phase with aphidicolin failed to dephosphorylate and activate cdc2, and this correlated with failure to convert cdc25C into the most active hyperphosphorylated species.	Aphidicolin	98-109	cyclin dependent kinase 1	Homo sapiens	149-153
7549180-6	1995	Cdc2 activities functioning as a G2/M regulator are controlled by its phosphorylation and dephosphorylation at Ser/Thr residues.	Serine	111-114	cyclin dependent kinase 1	Homo sapiens	0-4
7549180-6	1995	Cdc2 activities functioning as a G2/M regulator are controlled by its phosphorylation and dephosphorylation at Ser/Thr residues.	Threonine	115-118	cyclin dependent kinase 1	Homo sapiens	0-4
8069859-4	1994	Brief caffeine exposures (5 or 10 mM for 1-2 h) caused specific tyrosine dephosphorylation and activation of p34cdc2 kinase, and mitotic progression to a limited extent, in cells which were arrested in G2 following etoposide treatment.	Caffeine	6-14	cyclin dependent kinase 1	Homo sapiens	109-116
8069859-4	1994	Brief caffeine exposures (5 or 10 mM for 1-2 h) caused specific tyrosine dephosphorylation and activation of p34cdc2 kinase, and mitotic progression to a limited extent, in cells which were arrested in G2 following etoposide treatment.	Etoposide	215-224	cyclin dependent kinase 1	Homo sapiens	109-116
8078587-2	1994	CDK activation is dependent on cyclin binding and phosphorylation of a conserved threonine (T161 in Cdc2) mediated by the CDK-activating kinase CAK.	Threonine	81-90	cyclin dependent kinase 1	Homo sapiens	100-104
8090767-3	1994	We find that the mutant allele cdc2-2 confers sensitivity to killing by methyl methanesulfonate (MMS) but allows wild-type levels of UV survival.	Methyl Methanesulfonate	72-95	cyclin dependent kinase 1	Homo sapiens	31-37
8090767-3	1994	We find that the mutant allele cdc2-2 confers sensitivity to killing by methyl methanesulfonate (MMS) but allows wild-type levels of UV survival.	Methyl Methanesulfonate	97-100	cyclin dependent kinase 1	Homo sapiens	31-37
8090767-4	1994	MMS survival of haploid cdc2-2 strains is lower than wild type at the permissive growth temperature of 20 degrees C. Survival is further decreased relative to wild type by treatment with MMS at 36 degrees C, a nonpermissive temperature for growth of mutant cells.	Methyl Methanesulfonate	0-3	cyclin dependent kinase 1	Homo sapiens	24-30
8090767-7	1994	MMS sensitivity of a cdc2-2 mutant at 20 degrees C is complemented by expression of mammalian DNA polymerase beta, an enzyme that fills single-strand gaps in duplex DNA in vitro and whose only known catalytic activity is polymerization of deoxyribonucleotides.	Deoxyribonucleotides	239-259	cyclin dependent kinase 1	Homo sapiens	21-27
8058318-1	1994	Butyrolactone I is a selective inhibitor of the cyclin-dependent kinase (cdk) family.	butyrolactone I	0-15	cyclin dependent kinase 1	Homo sapiens	73-76
8069918-6	1994	Like other CDKs, MO15/CDK7 contains a conserved threonine required for full activity; mutation of this residue severely reduces CAK activity.	Threonine	48-57	cyclin dependent kinase 1	Homo sapiens	11-15
8076632-7	1994	Similar changes in the behaviour of basic residues were also observed upon tyrosine phosphorylation of a cdc2-derived peptide, suggesting that this potential of phosphorylation events to propagate directed structural changes may find a widespread utility in the activation of protein kinases and in the transduction of phosphorylation-based signalling.	Tyrosine	75-83	cyclin dependent kinase 1	Homo sapiens	105-109
8048926-1	1994	A 100kD microtubule-bundling protein dynamin was phosphorylated in vitro by cdc2 kinase to approximately 1 mol of phosphate/mol of dynamin at a serine residue.	Phosphates	114-123	cyclin dependent kinase 1	Homo sapiens	76-80
8048926-1	1994	A 100kD microtubule-bundling protein dynamin was phosphorylated in vitro by cdc2 kinase to approximately 1 mol of phosphate/mol of dynamin at a serine residue.	Serine	144-150	cyclin dependent kinase 1	Homo sapiens	76-80
8048970-5	1994	We show that p34cdc2 co-immunoprecipitated from mitotic Hela cell lysates with an anti human cyclin B1 antibody, but not from interphasic cell lysates, is able to phosphorylate efficiently wild-type Rap1GAP, but not a mutant in which the putative consensus site for phosphorylation by the cdc2 kinase (serine 484) has been altered.	Serine	302-308	cyclin dependent kinase 1	Homo sapiens	13-20
8048970-5	1994	We show that p34cdc2 co-immunoprecipitated from mitotic Hela cell lysates with an anti human cyclin B1 antibody, but not from interphasic cell lysates, is able to phosphorylate efficiently wild-type Rap1GAP, but not a mutant in which the putative consensus site for phosphorylation by the cdc2 kinase (serine 484) has been altered.	Serine	302-308	cyclin dependent kinase 1	Homo sapiens	16-20
17180006-6	1994	In this study we isolated RA-resistant 15N cell lines and analyzed their growth properties and changes in cell cycle related (cdc2, cdk2, cyclins A, B, D and E) and early response (fos and jun) gene expression to evaluate the role IGF2 may play in mediating RA resistance.	Tretinoin	26-28	cyclin dependent kinase 1	Homo sapiens	126-130