PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
34384259-11	2021	The phosphorylation levels of p38, JNK, ERK1/2, P65 and cAMP response element-binding protein (CREB) in the mouse were significantly reduced in AM1241 pretreatment, while the level of p-JNK increased.	AM 1241	144-150	cAMP responsive element binding protein 1	Mus musculus	56-93
34674602-5	2021	In GLUTag cells, AzA induces the cAMP-PKA-CREB signaling axis and increases the secretion of GLP-1, an enteroendocrine hormone with anti-obesity effects.	azelaic acid	17-20	cAMP responsive element binding protein 1	Mus musculus	42-46
34674602-5	2021	In GLUTag cells, AzA induces the cAMP-PKA-CREB signaling axis and increases the secretion of GLP-1, an enteroendocrine hormone with anti-obesity effects.	Cyclic AMP	33-37	cAMP responsive element binding protein 1	Mus musculus	42-46
34384259-11	2021	The phosphorylation levels of p38, JNK, ERK1/2, P65 and cAMP response element-binding protein (CREB) in the mouse were significantly reduced in AM1241 pretreatment, while the level of p-JNK increased.	AM 1241	144-150	cAMP responsive element binding protein 1	Mus musculus	95-99
34384259-12	2021	In addition, the P/T-P65 and P/T-CREB of the AM1241 pretreatment group were significantly reduced.	AM 1241	45-51	cAMP responsive element binding protein 1	Mus musculus	33-37
35500448-2	2022	This study aims to explore the molecular mechanism underlying antidepressant and analgetic effect of salvianolic acid B (SalB) in comorbid pain in depression induced by chronic restraint stress (CRS), which associates with GABAergic neuron activation in the amygdala and the ERK-CREB-BDNF signaling pathway.	salvianolic acid B	101-119	cAMP responsive element binding protein 1	Mus musculus	279-283
35500448-0	2022	Salvianolic acid B alleviates comorbid pain in depression induced by chronic restraint stress through inhibiting GABAergic neuron excitation via an ERK-CREB-BDNF axis-dependent mechanism.	salvianolic acid B	0-18	cAMP responsive element binding protein 1	Mus musculus	152-156
35636253-8	2022	In addition, myricetin intake upregulated the phosphorylation of CREB, the major transcription factor for BDNF and NGF.	myricetin	13-22	cAMP responsive element binding protein 1	Mus musculus	65-69
35537568-9	2022	CFA and IANX both greatly enhanced the expression of phospho (p)-NR2B, p-CaMKII, cyclic adenosine monophosphate (cAMP), p-ERK, and p-cAMP response element binding protein (CREB) in the TG and SpVc.	ianx	8-12	cAMP responsive element binding protein 1	Mus musculus	131-170
35537568-9	2022	CFA and IANX both greatly enhanced the expression of phospho (p)-NR2B, p-CaMKII, cyclic adenosine monophosphate (cAMP), p-ERK, and p-cAMP response element binding protein (CREB) in the TG and SpVc.	ianx	8-12	cAMP responsive element binding protein 1	Mus musculus	172-176
35537568-13	2022	These findings revealed novel molecular signaling pathways (NR2B-CaMKII-cAMP-ERK-CREB) in TG- and SpVc-derived latent subsequent peripheral and spinal central sensitization under nerve injury and inflammation, which might be beneficial for the treatment of orofacial allodynia.	Cyclic AMP	72-76	cAMP responsive element binding protein 1	Mus musculus	81-85
35106922-5	2022	The ratio of p-CaMKIV/CaMKIV and p-CREB1/CREB were increased at protein level in MC3T3 and MG63 cells after treatment with Mg2+ .	magnesium ion	123-127	cAMP responsive element binding protein 1	Mus musculus	35-40
35106922-5	2022	The ratio of p-CaMKIV/CaMKIV and p-CREB1/CREB were increased at protein level in MC3T3 and MG63 cells after treatment with Mg2+ .	magnesium ion	123-127	cAMP responsive element binding protein 1	Mus musculus	41-45
35500448-9	2022	After intraperitoneal injection of SalB, the depression-like behaviors and pain threshold in CRS mice were alleviated, the effects of which could be eliminated by ERK-CREB-BDNF signaling pathway antagonist.	salvianolic acid B	35-39	cAMP responsive element binding protein 1	Mus musculus	167-171
35378204-0	2022	Purkinje cell-specific deletion of CREB worsens alcohol-induced cerebellar neuronal losses and motor deficits.	Alcohols	48-55	cAMP responsive element binding protein 1	Mus musculus	35-39
35490894-9	2022	The results of WB showed crocin reversed the decreased contents of NAMPT, SIRT1, BDNF and pCREB/CREB in PFC induced by CRS.	crocin	25-31	cAMP responsive element binding protein 1	Mus musculus	96-100
35490894-9	2022	The results of WB showed crocin reversed the decreased contents of NAMPT, SIRT1, BDNF and pCREB/CREB in PFC induced by CRS.	3-cresol	119-122	cAMP responsive element binding protein 1	Mus musculus	96-100
35367313-0	2022	PPARalpha contributes to the therapeutic effect of hydrogen gas against sepsis-associated encephalopathy with the regulation to the CREB-BDNF signaling pathway and hippocampal neuron plasticity-related gene expression.	Hydrogen	51-59	cAMP responsive element binding protein 1	Mus musculus	132-136
35367313-5	2022	This study was designed to evaluate the expression of PPARalpha in SAE and determine whether H2 can alleviate SAE through regulation of the cAMP response element-binding protein (CREB)-brain-derived neurotrophic factor (BDNF) signaling pathway and its downstream proteins via PPARalpha.	Deuterium	93-95	cAMP responsive element binding protein 1	Mus musculus	140-177
35367313-5	2022	This study was designed to evaluate the expression of PPARalpha in SAE and determine whether H2 can alleviate SAE through regulation of the cAMP response element-binding protein (CREB)-brain-derived neurotrophic factor (BDNF) signaling pathway and its downstream proteins via PPARalpha.	Deuterium	93-95	cAMP responsive element binding protein 1	Mus musculus	179-183
35367313-13	2022	In addition, the GW6471 downregulated the expression of CREB, BDNF and other neurotrophins in SAE mice treated with H2.	GW 6471	17-23	cAMP responsive element binding protein 1	Mus musculus	56-60
35367313-13	2022	In addition, the GW6471 downregulated the expression of CREB, BDNF and other neurotrophins in SAE mice treated with H2.	Deuterium	116-118	cAMP responsive element binding protein 1	Mus musculus	56-60
35367313-15	2022	These results illustrated that H2 alleviates sepsis-induced brain injury in mice through the regulation of neurotrophins and hippocampal plasticity-related genes via PPARalpha by activating the CREB-BDNF signaling pathway.	Deuterium	31-33	cAMP responsive element binding protein 1	Mus musculus	194-198
35556130-6	2022	The cooperative mechanism driving synergistic gene expression is based on "assisted loading" whereby a glucagon-activated TF (cAMP responsive element binding protein; CREB) leads to enhancer activation which facilitates binding of the glucocorticoid receptor (GR) upon glucocorticoid stimulation.	Cyclic AMP	126-130	cAMP responsive element binding protein 1	Mus musculus	167-171
35378204-18	2022	However, in the presence of alcohol, disruption of CREB in Purkinje cells substantially worsened rotarod performance.	Alcohols	28-35	cAMP responsive element binding protein 1	Mus musculus	51-55
35378204-19	2022	DISCUSSION: Disruption of a single gene (CREB) in a single neuronal population (Purkinje cells) greatly increases the vulnerability of that cell population to alcohol-induced cell death and worsens alcohol-induced brain dysfunction.	Alcohols	159-166	cAMP responsive element binding protein 1	Mus musculus	41-45
35378204-19	2022	DISCUSSION: Disruption of a single gene (CREB) in a single neuronal population (Purkinje cells) greatly increases the vulnerability of that cell population to alcohol-induced cell death and worsens alcohol-induced brain dysfunction.	Alcohols	198-205	cAMP responsive element binding protein 1	Mus musculus	41-45
35378204-7	2022	A key molecule within the cAMP pathway is CREB.	Cyclic AMP	26-30	cAMP responsive element binding protein 1	Mus musculus	42-46
35378204-14	2022	However, the loss of CREB function from Purkinje cells greatly increased the vulnerability of Purkinje cells to alcohol-induced cell death.	Alcohols	112-119	cAMP responsive element binding protein 1	Mus musculus	21-25
35631808-10	2022	Lm-ME reduced the melanin expression of microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase-related protein-1/2 (TYRP-1/2) in alpha-melanocyte-stimulating hormone (alpha-MSH)-treated B16F10 cells via the reduction of cAMP response element-binding protein (CREB) and p38 activation.	lm-me	0-5	cAMP responsive element binding protein 1	Mus musculus	247-284
35278661-11	2022	However, the CREB inhibitor increased GABA content.	gamma-Aminobutyric Acid	38-42	cAMP responsive element binding protein 1	Mus musculus	13-17
35236775-10	2022	BLU2864 inhibited in vitro mIMCD3 cystogenesis and ex vivo P-Ser133 CREB expression and cystogenesis.	blu2864	0-7	cAMP responsive element binding protein 1	Mus musculus	68-72
35613591-2	2022	Here, we show that a small G-protein Gem, an endogenous inhibitor of high-voltage-activated voltage-dependent calcium channels (VDCCs), is rapidly induced by light in SCN neurons via the calcium (Ca2+)-mediated CREB/CRE transcriptional pathway.	Calcium	187-194	cAMP responsive element binding protein 1	Mus musculus	211-215
35628642-4	2022	In contrast, CPP increased the expression of REST, cAMP-responsive element binding (CREB) and transforming growth factor beta1 (TGF-beta1) in the young hippocampus.	Cyclic AMP	51-55	cAMP responsive element binding protein 1	Mus musculus	84-88
35609645-3	2022	Currently, it has been demonstrated that besides monoaminergic dysfunction, depression is accompanied by several other important pathological phenomena such as impaired neurogenesis and decreased brain-derived neurotrophic factor (BDNF)-cAMP response element binding protein (CREB) signaling cascade in the hippocampus.	Cyclic AMP	237-241	cAMP responsive element binding protein 1	Mus musculus	276-280
35631808-10	2022	Lm-ME reduced the melanin expression of microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase-related protein-1/2 (TYRP-1/2) in alpha-melanocyte-stimulating hormone (alpha-MSH)-treated B16F10 cells via the reduction of cAMP response element-binding protein (CREB) and p38 activation.	lm-me	0-5	cAMP responsive element binding protein 1	Mus musculus	286-290
35628302-0	2022	Pyruvate Upregulates Hepatic FGF21 Expression by Activating PDE and Inhibiting cAMP-Epac-CREB Signaling Pathway.	Pyruvic Acid	0-8	cAMP responsive element binding protein 1	Mus musculus	89-93
35594380-7	2022	Gain- and loss-of-function studies of PDE4D in cardiomyocytes implicated that inhibition of insulin-induced PDE4D protected cardiac hypertrophy by preserving miR-1 expression in cardiomyocytes through promoting cAMP-CREB-Sirt1 signaling-induced SERCA2a expression.	Cyclic AMP	211-215	cAMP responsive element binding protein 1	Mus musculus	216-220
35628302-0	2022	Pyruvate Upregulates Hepatic FGF21 Expression by Activating PDE and Inhibiting cAMP-Epac-CREB Signaling Pathway.	Cyclic AMP	79-83	cAMP responsive element binding protein 1	Mus musculus	89-93
35628302-7	2022	Pyruvate significantly increased PDE activities, reduced cAMP levels and decreased CREB phosphorylation.	Pyruvic Acid	0-8	cAMP responsive element binding protein 1	Mus musculus	83-87
35628302-8	2022	The inhibition of exchange protein directed activated by cAMP (Epac) and cAMP response element binding protein (CREB) upregulated FGF21 expression, upon which pyruvate no longer increased FGF21 expression.	Pyruvic Acid	159-167	cAMP responsive element binding protein 1	Mus musculus	73-110
35628302-8	2022	The inhibition of exchange protein directed activated by cAMP (Epac) and cAMP response element binding protein (CREB) upregulated FGF21 expression, upon which pyruvate no longer increased FGF21 expression.	Pyruvic Acid	159-167	cAMP responsive element binding protein 1	Mus musculus	112-116
35628302-9	2022	The increase in plasma pyruvate levels in mice induced by the intraperitoneal injection of pyruvate significantly increased FGF21 gene expression and PDE activity with a reduction in cAMP levels and CREB phosphorylation in the mouse liver compared with the control.	Pyruvic Acid	23-31	cAMP responsive element binding protein 1	Mus musculus	199-203
35628302-9	2022	The increase in plasma pyruvate levels in mice induced by the intraperitoneal injection of pyruvate significantly increased FGF21 gene expression and PDE activity with a reduction in cAMP levels and CREB phosphorylation in the mouse liver compared with the control.	Pyruvic Acid	91-99	cAMP responsive element binding protein 1	Mus musculus	199-203
35628302-10	2022	In conclusion, pyruvate activates PDEs to reduce cAMP and then inhibits the cAMP-Epac-CREB signaling pathway to upregulate FGF21 expression in hepatocytes.	Pyruvic Acid	15-23	cAMP responsive element binding protein 1	Mus musculus	86-90
35628302-10	2022	In conclusion, pyruvate activates PDEs to reduce cAMP and then inhibits the cAMP-Epac-CREB signaling pathway to upregulate FGF21 expression in hepatocytes.	Cyclic AMP	76-80	cAMP responsive element binding protein 1	Mus musculus	86-90
35307786-8	2022	Furthermore, an increase in the CREB and Atf-1 expressions suggested the melatonin"s strong reformative effect on neuronal regeneration.	Melatonin	73-82	cAMP responsive element binding protein 1	Mus musculus	32-36
35624812-8	2022	Baicalein also promoted the expression of CREB, which plays a role in a variety of signaling pathways.	baicalein	0-9	cAMP responsive element binding protein 1	Mus musculus	42-46
35613826-14	2022	Furthermore, both the Creb inhibitor and recombinant mouse Ccl3 significantly enhanced DTX chemosensitivity.	Docetaxel	87-90	cAMP responsive element binding protein 1	Mus musculus	22-26
35451558-8	2022	The following rescue assay indicated that CREB1 was implicated in the anti-tumoral effect of mR-450a in breast carcinoma.	mr-450a	93-100	cAMP responsive element binding protein 1	Mus musculus	42-47
35501151-4	2022	An MPTP mouse model was used to further elucidate the mechanism underlying CREB dephosphorylation.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	3-7	cAMP responsive element binding protein 1	Mus musculus	75-79
35501151-9	2022	Disrupting CREB/HDAC1 interaction via either overexpression of GAL4 M1, a CREB mutant, or administration of trichostatin A, a pan-HDAC inhibitor, restored the expression levels of phospho-CREB (Ser133) and NURR1, and protected nigral dopaminergic neurons in the MPTP-treated mice brain.	trichostatin A	108-122	cAMP responsive element binding protein 1	Mus musculus	11-15
35501151-9	2022	Disrupting CREB/HDAC1 interaction via either overexpression of GAL4 M1, a CREB mutant, or administration of trichostatin A, a pan-HDAC inhibitor, restored the expression levels of phospho-CREB (Ser133) and NURR1, and protected nigral dopaminergic neurons in the MPTP-treated mice brain.	trichostatin A	108-122	cAMP responsive element binding protein 1	Mus musculus	188-192
35501151-9	2022	Disrupting CREB/HDAC1 interaction via either overexpression of GAL4 M1, a CREB mutant, or administration of trichostatin A, a pan-HDAC inhibitor, restored the expression levels of phospho-CREB (Ser133) and NURR1, and protected nigral dopaminergic neurons in the MPTP-treated mice brain.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	262-266	cAMP responsive element binding protein 1	Mus musculus	11-15
35501151-9	2022	Disrupting CREB/HDAC1 interaction via either overexpression of GAL4 M1, a CREB mutant, or administration of trichostatin A, a pan-HDAC inhibitor, restored the expression levels of phospho-CREB (Ser133) and NURR1, and protected nigral dopaminergic neurons in the MPTP-treated mice brain.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	262-266	cAMP responsive element binding protein 1	Mus musculus	74-78
35501151-9	2022	Disrupting CREB/HDAC1 interaction via either overexpression of GAL4 M1, a CREB mutant, or administration of trichostatin A, a pan-HDAC inhibitor, restored the expression levels of phospho-CREB (Ser133) and NURR1, and protected nigral dopaminergic neurons in the MPTP-treated mice brain.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	262-266	cAMP responsive element binding protein 1	Mus musculus	188-192
35501151-15	2022	Disrupting CREB/HDAC1 interaction restored CREB activity and protected nigral dopaminergic neurons in the MPTP mouse brains.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	106-110	cAMP responsive element binding protein 1	Mus musculus	11-15
35258009-5	2022	The forskolin-stimulated inductions of Pck1 and G6pc were also dramatically reduced in primary hepatocytes isolated from Ncoa6 LKO mice, whereas the expression levels of other gluconeogenic gene regulators, including cAMP response element binding protein (Creb), forkhead box protein O1 and peroxisome proliferator-activated receptor gamma coactivator 1alpha, were unaltered in the LKO mouse livers.	Colforsin	4-13	cAMP responsive element binding protein 1	Mus musculus	217-254
35258009-5	2022	The forskolin-stimulated inductions of Pck1 and G6pc were also dramatically reduced in primary hepatocytes isolated from Ncoa6 LKO mice, whereas the expression levels of other gluconeogenic gene regulators, including cAMP response element binding protein (Creb), forkhead box protein O1 and peroxisome proliferator-activated receptor gamma coactivator 1alpha, were unaltered in the LKO mouse livers.	Colforsin	4-13	cAMP responsive element binding protein 1	Mus musculus	256-260
35258009-6	2022	CREB phosphorylation via fasting or forskolin stimulation was normal in the livers and primary hepatocytes of the LKO mice.	Colforsin	36-45	cAMP responsive element binding protein 1	Mus musculus	0-4
35258009-10	2022	Our present results suggest that NCOA6 regulates hepatic gluconeogenesis by modulating glucagon/cAMP-dependent gluconeogenic gene transcription through an interaction with CREB.	Cyclic AMP	96-100	cAMP responsive element binding protein 1	Mus musculus	172-176
35325017-6	2022	Moreover, daphnetin downregulated the phosphorylation of PKA, ERK, MSK1, and CREB.	daphnetin	10-19	cAMP responsive element binding protein 1	Mus musculus	77-81
35457238-5	2022	Further research revealed that GTS-21 has anti-inflammatory properties by inhibiting PI3K/Akt, NF-kappaB, and upregulating AMPK, Nrf2, CREB, and PPARgamma signals.	3-(2,4-dimethoxybenzylidene)anabaseine	31-37	cAMP responsive element binding protein 1	Mus musculus	135-139
35325017-8	2022	Our data propose that daphnetin inhibits melanogenesis via modulating both the PKA/CREB and the ERK/MSK1/CREB pathways.	daphnetin	22-31	cAMP responsive element binding protein 1	Mus musculus	83-87
35325017-8	2022	Our data propose that daphnetin inhibits melanogenesis via modulating both the PKA/CREB and the ERK/MSK1/CREB pathways.	daphnetin	22-31	cAMP responsive element binding protein 1	Mus musculus	105-109
35394127-6	2022	The TLR4, brain-derived neurotrophic factor (BDNF) and cyclic adenosine monophosphate response element-binding protein 1 (CREB1) mRNA expressions were detected using quantitative real-time polymerase chain reaction (qRT-PCR).	Adenosine	62-71	cAMP responsive element binding protein 1	Mus musculus	122-127
35481228-8	2022	Propranolol reversed CREB and Nrf2 activity (ps < .03).	Propranolol	0-11	cAMP responsive element binding protein 1	Mus musculus	21-25
35412062-0	2022	Dexmedetomidine attenuates hippocampal neuroinflammation in postoperative neurocognitive disorders by inhibiting microRNA-329-3p and activating the CREB1/IL1RA axis.	Dexmedetomidine	0-15	cAMP responsive element binding protein 1	Mus musculus	148-153
35412062-14	2022	CONCLUSIONS: Collectively, our data provided the novel insight of the neuroprotective mechanism of DEX in postoperative NCD pertaining to the miR-329-3p/CREB1/IL1RA axis.	Dexmedetomidine	99-102	cAMP responsive element binding protein 1	Mus musculus	153-158
35412062-14	2022	CONCLUSIONS: Collectively, our data provided the novel insight of the neuroprotective mechanism of DEX in postoperative NCD pertaining to the miR-329-3p/CREB1/IL1RA axis.	mir-329	142-149	cAMP responsive element binding protein 1	Mus musculus	153-158
35394127-13	2022	Compared with the isoflurane group, the apoptosis rate of the TLR-siRNA group was significantly decreased, BDNF and CREB1 protein expressions were significantly increased, and ERK1/2 and JNK did not change significantly.	Isoflurane	18-28	cAMP responsive element binding protein 1	Mus musculus	116-121
35478969-0	2022	Naringin Mediates Adult Hippocampal Neurogenesis for Antidepression via Activating CREB Signaling.	naringin	0-8	cAMP responsive element binding protein 1	Mus musculus	83-87
35478969-0	2022	Naringin Mediates Adult Hippocampal Neurogenesis for Antidepression via Activating CREB Signaling.	antidepression	53-67	cAMP responsive element binding protein 1	Mus musculus	83-87
35478969-1	2022	The brain-derived neurotrophic factor/tropomyosin receptor kinase B/cAMP response element-binding protein (BDNF/TrkB/CREB) signaling pathway is a critical therapeutic target for inducing adult hippocampal neurogenesis and antidepressant therapy.	Cyclic AMP	68-72	cAMP responsive element binding protein 1	Mus musculus	117-121
35478969-2	2022	In this study, we tested the hypothesis that naringin, a natural medicinal compound, could promote adult hippocampal neurogenesis and improve depression-like behaviors via regulating the BDNF/TrkB/CREB signaling pathway.	naringin	45-53	cAMP responsive element binding protein 1	Mus musculus	197-201
35478969-8	2022	Meanwhile, naringin treatment increased phosphorylation of cAMP response element binding protein (CREB) but had no effect on the expression of brain-derived neurotrophic factor and phosphorylation of TrkB in the hippocampus of CORT-induced depressive mice.	naringin	11-19	cAMP responsive element binding protein 1	Mus musculus	59-96
35478969-8	2022	Meanwhile, naringin treatment increased phosphorylation of cAMP response element binding protein (CREB) but had no effect on the expression of brain-derived neurotrophic factor and phosphorylation of TrkB in the hippocampus of CORT-induced depressive mice.	naringin	11-19	cAMP responsive element binding protein 1	Mus musculus	98-102
35478969-9	2022	Co-treatment of CREB inhibitor 666-15, rather than TrkB inhibitor Cyc-B, abolished the neurogenesis-promoting and antidepressant effects of naringin.	naringin	140-148	cAMP responsive element binding protein 1	Mus musculus	16-20
35478969-10	2022	Taken together, naringin has antidepressant and anxiolytic effects, and the underlying mechanisms could be attributed to enhance hippocampal neurogenesis via activating CREB signaling.	naringin	16-24	cAMP responsive element binding protein 1	Mus musculus	169-173
35260558-0	2022	Hepatoprotective effects of sevoflurane against hepatic ischemia-reperfusion injury by regulating microRNA-124-3p-mediated TRAF3/CREB axis.	Sevoflurane	28-39	cAMP responsive element binding protein 1	Mus musculus	129-133
35318613-5	2022	In this report, we identify a crucial role for the NAD+-dependent histone deacetylase Sirtuin 1 (Sirt1) downstream of PKA and CREB in dmPGE2-dependent radioprotection of hematopoietic cells.	NAD	51-55	cAMP responsive element binding protein 1	Mus musculus	126-130
35318613-5	2022	In this report, we identify a crucial role for the NAD+-dependent histone deacetylase Sirtuin 1 (Sirt1) downstream of PKA and CREB in dmPGE2-dependent radioprotection of hematopoietic cells.	16,16-Dimethylprostaglandin E2	134-140	cAMP responsive element binding protein 1	Mus musculus	126-130
35368248-12	2022	Therefore, the CCK analogue promotes cell survival of dopaminergic neuron in the SNpc by activating the cAMP/PKA/CREB pathway that also inhibits apoptosis and regulates autophagy impairment.	Cyclic AMP	104-108	cAMP responsive element binding protein 1	Mus musculus	113-117
35256606-8	2022	At the molecular level, we found that HL-43/EP4 regulated cartilage anabolism through the cAMP/PKA/CREB/Sox9 signaling.	Cyclic AMP	90-94	cAMP responsive element binding protein 1	Mus musculus	99-103
35345315-8	2022	Furthermore, 0.50 mM Arg increased the concentrations of cAMP and the abundances of phosphorylated cAMP-dependent protein kinase A (PKA), phosphorylated PKA alpha/beta/gamma, and phosphorylated CREB.	Arginine	21-24	cAMP responsive element binding protein 1	Mus musculus	194-198
35179534-5	2022	Moreover, sesamol treatment improved brain-derived neurotrophic factor (BDNF) by upregulating the BDNF/TrkB/CREB signaling pathway, restored synaptic impairments and enhanced norepinephrine (NE) and serotonin (5-HT) levels.	sesamol	10-17	cAMP responsive element binding protein 1	Mus musculus	108-112
35080066-8	2022	Furthermore, we found that Firmicutes and Bacteroidetes affect the de novo synthesis of glutathione (GSH) by regulating its key enzyme glutamate-cysteine ligase catalytic subunit (Gclc) and inhibiting mitochondrial biogenesis and ROS accumulation via the cAMP response element-binding (CREB) pathway.	Glutathione	88-99	cAMP responsive element binding protein 1	Mus musculus	255-284
35080066-8	2022	Furthermore, we found that Firmicutes and Bacteroidetes affect the de novo synthesis of glutathione (GSH) by regulating its key enzyme glutamate-cysteine ligase catalytic subunit (Gclc) and inhibiting mitochondrial biogenesis and ROS accumulation via the cAMP response element-binding (CREB) pathway.	Glutathione	88-99	cAMP responsive element binding protein 1	Mus musculus	286-290
35080066-8	2022	Furthermore, we found that Firmicutes and Bacteroidetes affect the de novo synthesis of glutathione (GSH) by regulating its key enzyme glutamate-cysteine ligase catalytic subunit (Gclc) and inhibiting mitochondrial biogenesis and ROS accumulation via the cAMP response element-binding (CREB) pathway.	Glutathione	101-104	cAMP responsive element binding protein 1	Mus musculus	255-284
35080066-8	2022	Furthermore, we found that Firmicutes and Bacteroidetes affect the de novo synthesis of glutathione (GSH) by regulating its key enzyme glutamate-cysteine ligase catalytic subunit (Gclc) and inhibiting mitochondrial biogenesis and ROS accumulation via the cAMP response element-binding (CREB) pathway.	Glutathione	101-104	cAMP responsive element binding protein 1	Mus musculus	286-290
35025141-0	2022	LY395756 promotes NR2B expression via activation of AKT/CREB signaling in the juvenile methylazoxymethanol mice model of schizophrenia.	2-amino-4-methylbicyclo(3.1.0)hexane2,6-dicarboxylic acid	0-8	cAMP responsive element binding protein 1	Mus musculus	56-60
35129858-7	2022	Moreover, ACh or alpha7 nAChR agonist suppressed the LPS-induced production of pro-inflammatory cytokines, as well as the phagocytosis of microglia, by activating alpha7 nAChR and followed by the regulation of NF-kappaB and CREB signaling.	Acetylcholine	10-13	cAMP responsive element binding protein 1	Mus musculus	224-228
35299662-0	2022	Empagliflozin Inhibits Hepatic Gluconeogenesis and Increases Glycogen Synthesis by AMPK/CREB/GSK3beta Signalling Pathway.	empagliflozin	0-13	cAMP responsive element binding protein 1	Mus musculus	88-92
35299662-0	2022	Empagliflozin Inhibits Hepatic Gluconeogenesis and Increases Glycogen Synthesis by AMPK/CREB/GSK3beta Signalling Pathway.	Glycogen	61-69	cAMP responsive element binding protein 1	Mus musculus	88-92
35299662-8	2022	Empagliflozin could also prevent the decreases in glycogen content and regulate the protein expression levels of AMPK/CREB/GSK3beta signalling pathway-related molecules.	empagliflozin	0-13	cAMP responsive element binding protein 1	Mus musculus	118-122
35299662-10	2022	The results of the 5-Aminoimidazole-4-carboxamide1-beta-D-ribofuranoside (AIACR) intervention in HL7702 cells were consistent with those of empagliflozin treatment, and the effects of empagliflozin were abolished by compound C. In summary, empagliflozin could maintain glucose homoeostasis by reducing gluconeogenesis and increasing glycogenesis through the AMPK/CREB/GSK3beta signalling pathway.	acadesine	74-79	cAMP responsive element binding protein 1	Mus musculus	363-367
35104500-4	2022	METHODS: GPCR-targeted piggyBac-TANGO compound screening system, cAMP assay, and immunostaining of p-CREB and BDNF were used to identify dopamine 2 receptor (DRD2) activation.	Dopamine	137-145	cAMP responsive element binding protein 1	Mus musculus	101-105
35104500-6	2022	RESULTS: Atractylon treatment increased the eGFP expression in dose-dependent manner in piggyBac-TANGO assay, decreased cAMP production, and enhanced the levels of p-CREB and BDNF in DRD2 highly expressed SY-SY5Y cells.	atractylon	9-19	cAMP responsive element binding protein 1	Mus musculus	166-170
35216322-2	2022	In this study, we assessed the capsaicin- or zinc- induced activation of signalling molecules including calcium/calmodulin-dependent protein kinase 2 (CAMKK2), cAMP-response element-binding protein (CREB), and target of rapamycin kinase complex 1 (TORC1).	Capsaicin	31-40	cAMP responsive element binding protein 1	Mus musculus	160-197
35216322-2	2022	In this study, we assessed the capsaicin- or zinc- induced activation of signalling molecules including calcium/calmodulin-dependent protein kinase 2 (CAMKK2), cAMP-response element-binding protein (CREB), and target of rapamycin kinase complex 1 (TORC1).	Capsaicin	31-40	cAMP responsive element binding protein 1	Mus musculus	199-203
35154573-5	2022	The results showed that 10 Hz electroacupuncture (EA) effectively alleviated learning and memory impairment in 7-month-old SAMP8 mice, reduced OxA levels in the CSF, increased the level of the neurotransmitter glutamate, alleviated pathological damage to hippocampal tissue, improved the synaptic structure, enhanced synaptic transmission, and regulated the expression of cAMP/PKA/CREB signaling pathway-related proteins.	Glutamic Acid	210-219	cAMP responsive element binding protein 1	Mus musculus	381-385
35154573-6	2022	These results suggest that EA enhances neuroplasticity in SAMP8 mice by regulating the OxA-mediated cAMP/PKA/CREB signaling pathway, thus improving cognitive function.	Cyclic AMP	100-104	cAMP responsive element binding protein 1	Mus musculus	109-113
35025141-12	2022	Taken together, these findings support that the AKT/CREB signaling pathway is essential for the promoting effect of LY395756 on synaptic NR2B in PFC in juvenile MAM mice SCZ model.	2-amino-4-methylbicyclo(3.1.0)hexane2,6-dicarboxylic acid	116-124	cAMP responsive element binding protein 1	Mus musculus	52-56
35163281-0	2022	Calycosin, a Common Dietary Isoflavonoid, Suppresses Melanogenesis through the Downregulation of PKA/CREB and p38 MAPK Signaling Pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	cAMP responsive element binding protein 1	Mus musculus	101-105
35091686-8	2022	Furthermore, PTA administration reduced amyloid plaque deposition in the hippocampus by promoting microglial phagocytosis; PTA administration improved synaptic integrity through enhancing BDNF/TrkB/CREB signaling, ameliorated oxidative stress by Catalase level, and regulated Bcl-2 family proteins in the hippocampus.	patchouli alcohol	13-16	cAMP responsive element binding protein 1	Mus musculus	198-202
35091686-8	2022	Furthermore, PTA administration reduced amyloid plaque deposition in the hippocampus by promoting microglial phagocytosis; PTA administration improved synaptic integrity through enhancing BDNF/TrkB/CREB signaling, ameliorated oxidative stress by Catalase level, and regulated Bcl-2 family proteins in the hippocampus.	patchouli alcohol	123-126	cAMP responsive element binding protein 1	Mus musculus	198-202
35203954-7	2022	Interestingly, further investigations revealed that gelsemine inhibited the CUMS-induced activation of NLRP3-inflammasome pathways and downregulated CREB and BDNF overexpression in the hypothalamus.	gelsemine	52-61	cAMP responsive element binding protein 1	Mus musculus	149-153
35203954-7	2022	Interestingly, further investigations revealed that gelsemine inhibited the CUMS-induced activation of NLRP3-inflammasome pathways and downregulated CREB and BDNF overexpression in the hypothalamus.	cums	76-80	cAMP responsive element binding protein 1	Mus musculus	149-153
35203954-9	2022	Gelsemine exerted its anxiolytic effects by modulating the NLRP3 and CREB/BDNF pathways.	gelsemine	0-9	cAMP responsive element binding protein 1	Mus musculus	69-73
35163281-5	2022	Mechanistically, we obtained the first evidence that calycosin-mediated MITF downregulation was attributable to its ability to block signaling pathways mediated by cAMP response element-binding protein (CREB) and p38 MAP kinase.	7,3'-dihydroxy-4'-methoxyisoflavone	53-62	cAMP responsive element binding protein 1	Mus musculus	164-201
35163281-5	2022	Mechanistically, we obtained the first evidence that calycosin-mediated MITF downregulation was attributable to its ability to block signaling pathways mediated by cAMP response element-binding protein (CREB) and p38 MAP kinase.	7,3'-dihydroxy-4'-methoxyisoflavone	53-62	cAMP responsive element binding protein 1	Mus musculus	203-207
35163281-6	2022	The protein kinase A (PKA) inhibitor H-89 and p38 inhibitor SB203580 validated the premise that calycosin inhibits melanin synthesis and tyrosinase activity by regulating the PKA/CREB and p38 MAPK signaling pathways.	7,3'-dihydroxy-4'-methoxyisoflavone	96-105	cAMP responsive element binding protein 1	Mus musculus	179-183
35163115-8	2022	Furthermore, bee venom treatment activated the tropomyosin-related kinase receptor B (TrkB)/cAMP response element-binding (CREB)/brain-derived neurotrophic factor (BDNF), which is closely related to the promotion of cellular antioxidant defense and neuronal functions.	Cyclic AMP	92-96	cAMP responsive element binding protein 1	Mus musculus	123-127
34635983-2	2022	Herein, we report the interactions among long noncoding RNA X-inactive specific transcript (XIST)/microRNA-135 (miR-135)/cAMP response element-binding protein 1 (CREB1) axis during fracture healing.	Cyclic AMP	121-125	cAMP responsive element binding protein 1	Mus musculus	162-167
35114451-0	2022	Natural Citrus flavanone 5-demethylnobiletin stimulates melanogenesis through the activation of cAMP/CREB pathway in B16F10 cells.	citrus flavanone 5-demethylnobiletin	8-44	cAMP responsive element binding protein 1	Mus musculus	101-105
35114451-0	2022	Natural Citrus flavanone 5-demethylnobiletin stimulates melanogenesis through the activation of cAMP/CREB pathway in B16F10 cells.	Cyclic AMP	96-100	cAMP responsive element binding protein 1	Mus musculus	101-105
35114451-7	2022	RESULTS: As confirmed by multiple biological assays, 5-demethylnobiletin is found to stimulate dendrite structure formation in cells, melanin synthesis and the transportation of melanosomes, via inducing the phosphorylation of cAMP response element-binding protein (CREB) and increasing the intracellular levels of cAMP in vitro through the PKA-dependent pathway.	5-demethylnobiletin	53-72	cAMP responsive element binding protein 1	Mus musculus	227-264
35114451-7	2022	RESULTS: As confirmed by multiple biological assays, 5-demethylnobiletin is found to stimulate dendrite structure formation in cells, melanin synthesis and the transportation of melanosomes, via inducing the phosphorylation of cAMP response element-binding protein (CREB) and increasing the intracellular levels of cAMP in vitro through the PKA-dependent pathway.	5-demethylnobiletin	53-72	cAMP responsive element binding protein 1	Mus musculus	266-270
35114451-7	2022	RESULTS: As confirmed by multiple biological assays, 5-demethylnobiletin is found to stimulate dendrite structure formation in cells, melanin synthesis and the transportation of melanosomes, via inducing the phosphorylation of cAMP response element-binding protein (CREB) and increasing the intracellular levels of cAMP in vitro through the PKA-dependent pathway.	Cyclic AMP	315-319	cAMP responsive element binding protein 1	Mus musculus	227-264
35020776-1	2022	cAMP responsive element binding protein (CREB)-regulated transcription coactivators (CRTCs) regulate gene transcription in response to an increase in intracellular cAMP or Ca2+ levels.	Cyclic AMP	164-168	cAMP responsive element binding protein 1	Mus musculus	0-39
35020776-1	2022	cAMP responsive element binding protein (CREB)-regulated transcription coactivators (CRTCs) regulate gene transcription in response to an increase in intracellular cAMP or Ca2+ levels.	Cyclic AMP	164-168	cAMP responsive element binding protein 1	Mus musculus	41-45
35017472-2	2022	Here, we report that Brazilian green propolis reduces fasting blood glucose levels in obese mice by disrupting the formation of CREB/CRTC2 transcriptional complex, a key regulator of hepatic gluconeogenesis.	Glucose	68-75	cAMP responsive element binding protein 1	Mus musculus	128-132
34635983-6	2022	Furthermore, miR-135 targeted CREB1 and negatively regulated its expression.	mir-135	13-20	cAMP responsive element binding protein 1	Mus musculus	30-35
34635983-7	2022	XIST acted as a sponge for miR-135, thereby upregulating CREB1 and promoting the activity of the TNF-alpha/RANKL pathway.	mir-135	27-34	cAMP responsive element binding protein 1	Mus musculus	57-62
35527006-12	2022	Overall, omega-3 supplementation significantly elevated the BDNF/TrkB/CREB pathway and restores anti-oxidants by upregulating the Nrf2/HO-1, thereby improving cognitive function in offspring after prenatal lead exposure.	Fatty Acids, Omega-3	9-16	cAMP responsive element binding protein 1	Mus musculus	70-74
2559873-5	1989	The AP-1 activity binds efficiently to both AP-1 and activating transcription factor (ATF)/cAMP response element binding protein (CREB)-binding sites present in E1A-inducible promoters and presumably plays a role in the transcriptional activation of adenovirus genes by E1A proteins and cAMP.	Cyclic AMP	91-95	cAMP responsive element binding protein 1	Mus musculus	130-134
35527006-8	2022	The protein and mRNA levels of BDNF, TrkB and CREB in the prenatal lead exposure group were significantly upregulated by omega-3 supplementation.	Fatty Acids, Omega-3	121-128	cAMP responsive element binding protein 1	Mus musculus	46-50
2559873-5	1989	The AP-1 activity binds efficiently to both AP-1 and activating transcription factor (ATF)/cAMP response element binding protein (CREB)-binding sites present in E1A-inducible promoters and presumably plays a role in the transcriptional activation of adenovirus genes by E1A proteins and cAMP.	Cyclic AMP	287-291	cAMP responsive element binding protein 1	Mus musculus	130-134
34036389-0	2021	kappa-opioid receptor agonist, U50488H, inhibits pyroptosis through NLRP3 via the Ca2+/CaMKII/CREB signaling pathway and improves synaptic plasticity in APP/PS1 mice.	3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer	31-38	cAMP responsive element binding protein 1	Mus musculus	94-98
2557542-7	1989	These data suggest that cyclic AMP response element-binding protein (ATF/CREB) or related proteins activate V beta transcription.	Cyclic AMP	24-34	cAMP responsive element binding protein 1	Mus musculus	73-77
33677283-6	2021	Further mechanistic investigation showed that Cd exposure upregulated the expression of key proteins in hepatic gluconeogenesis, including p-CREB, PGC-1alpha and G6PC, in pubertal and adult offspring.	Cadmium	46-48	cAMP responsive element binding protein 1	Mus musculus	141-145
34036389-6	2021	The underlying mechanism of the Ca2+/calcium/calmodulin-dependent protein kinase II/cyclic adenosine monophosphate-response element binding protein (Ca2+/CaMKII/CREB) signaling pathway was evaluated.	Calcium	37-44	cAMP responsive element binding protein 1	Mus musculus	161-165
34036389-6	2021	The underlying mechanism of the Ca2+/calcium/calmodulin-dependent protein kinase II/cyclic adenosine monophosphate-response element binding protein (Ca2+/CaMKII/CREB) signaling pathway was evaluated.	Adenosine	91-100	cAMP responsive element binding protein 1	Mus musculus	161-165
33745981-0	2021	Quercetin alleviates chronic unpredictable mild stress-induced depressive-like behaviors by promoting adult hippocampal neurogenesis via FoxG1/CREB/ BDNF signaling pathway.	Quercetin	0-9	cAMP responsive element binding protein 1	Mus musculus	143-147
34047500-8	2021	The binding relationship between miR-128 and CREB1 was verified.	mir-128	33-40	cAMP responsive element binding protein 1	Mus musculus	45-50
34058234-7	2021	BPA exposure reduced the levels of synaptic structural proteins and PKC/ERK/CREB pathway proteins, and ALA improved these reductions.	bisphenol A	0-3	cAMP responsive element binding protein 1	Mus musculus	76-80
34048869-8	2021	Treatment with AM4113 also increased the mRNA levels of Creb1 and Cbp in the amygdala as well as the protein levels of pCREB, CBP, H3K9ac and H3K14ac in the central and medial nucleus of amygdala, but not in the basolateral amygdala.	AM4113	15-21	cAMP responsive element binding protein 1	Mus musculus	56-61
33745981-9	2021	Besides, the expression levels of FoxG1, p-CREB and Brain-derived neurotrophic factor (BDNF) were also enhanced by quercetin in the DG.	Quercetin	115-124	cAMP responsive element binding protein 1	Mus musculus	43-47
34029649-0	2021	Levo-tetrahydropalmatine attenuates the acquisition of fentanyl-induced conditioned place preference and the changes in ERK and CREB phosphorylation expression in mice.	tetrahydropalmatine	0-24	cAMP responsive element binding protein 1	Mus musculus	128-132
34029649-4	2021	Western blot assays were used to dissect the accompanying changes in the phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP response element binding protein (CREB) in related brain regions, including the hippocampus (Hip), caudate putamen (CPu), prefrontal cortex (PFC), and nucleus accumbens (NAc), which may mediate the effects of L-THP on fentanyl-induced CPP.	Fentanyl	363-371	cAMP responsive element binding protein 1	Mus musculus	179-183
34029649-6	2021	The levels of p-ERK and p-CREB of the fentanyl group (0.05 mg/kg) increased significantly in the Hip, NAc, and PFC compared to the saline group.	Fentanyl	38-46	cAMP responsive element binding protein 1	Mus musculus	26-30
34029649-4	2021	Western blot assays were used to dissect the accompanying changes in the phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP response element binding protein (CREB) in related brain regions, including the hippocampus (Hip), caudate putamen (CPu), prefrontal cortex (PFC), and nucleus accumbens (NAc), which may mediate the effects of L-THP on fentanyl-induced CPP.	tetrahydropalmatine	354-359	cAMP responsive element binding protein 1	Mus musculus	179-183
34029649-7	2021	Furthermore, L-THP (10.0 mg/kg) co-administered with fentanyl during conditioning prevented the enhanced phosphorylation of ERK and CREB in the Hip, NAc, and PFC.	tetrahydropalmatine	13-18	cAMP responsive element binding protein 1	Mus musculus	132-136
34049220-15	2021	Moreover, Pt-induced anti-melanogenic activity through the downregulation of CREB-MITF pathway-mediated TRP-1/-2, tyrosinase expressions, melanosome formation, and melanin synthesis was substantially reversed due to 3-MA (autophagy inhibitor) pretreatment or LC3 silencing in B16F10 cells.	pterostilbene	10-12	cAMP responsive element binding protein 1	Mus musculus	77-81
34029649-7	2021	Furthermore, L-THP (10.0 mg/kg) co-administered with fentanyl during conditioning prevented the enhanced phosphorylation of ERK and CREB in the Hip, NAc, and PFC.	Fentanyl	53-61	cAMP responsive element binding protein 1	Mus musculus	132-136
34029649-8	2021	Our research revealed that L-THP could suppress the rewarding properties of fentanyl-induced CPP, the inhibitory effect may be related to the suppression of ERK and CREB phosphorylation in the Hip, NAc, and PFC of mice.	tetrahydropalmatine	27-32	cAMP responsive element binding protein 1	Mus musculus	165-169
34029649-8	2021	Our research revealed that L-THP could suppress the rewarding properties of fentanyl-induced CPP, the inhibitory effect may be related to the suppression of ERK and CREB phosphorylation in the Hip, NAc, and PFC of mice.	Fentanyl	76-84	cAMP responsive element binding protein 1	Mus musculus	165-169
34023501-0	2021	Tachypacing-induced CREB/CD44 signaling contributes to the suppression of L-type calcium channel expression and the development of atrial remodeling.	Calcium	81-88	cAMP responsive element binding protein 1	Mus musculus	20-24
34023501-4	2021	METHODS AND RESULTS: In vitro, tachypacing in atrium-derived myocytes (HL-1 cell line) induced an activation (phosphorylation) of cyclic AMP response element (CRE)-binding protein (CREB).	Cyclic AMP	130-140	cAMP responsive element binding protein 1	Mus musculus	181-185
34049220-15	2021	Moreover, Pt-induced anti-melanogenic activity through the downregulation of CREB-MITF pathway-mediated TRP-1/-2, tyrosinase expressions, melanosome formation, and melanin synthesis was substantially reversed due to 3-MA (autophagy inhibitor) pretreatment or LC3 silencing in B16F10 cells.	Melanins	164-171	cAMP responsive element binding protein 1	Mus musculus	77-81
34049220-15	2021	Moreover, Pt-induced anti-melanogenic activity through the downregulation of CREB-MITF pathway-mediated TRP-1/-2, tyrosinase expressions, melanosome formation, and melanin synthesis was substantially reversed due to 3-MA (autophagy inhibitor) pretreatment or LC3 silencing in B16F10 cells.	3-methyladenine	216-220	cAMP responsive element binding protein 1	Mus musculus	77-81
34001860-4	2021	Moreover, DA-DRD5 signaling can inhibit M1 by negatively regulating NF-kappaB signaling but promote M2 macrophage polarization through activation of the CREB pathway, respectively.	Dopamine	10-12	cAMP responsive element binding protein 1	Mus musculus	153-157
33982674-7	2021	Sevoflurane treatment or silencing RASD1 reduced RASD1 expression, CK, LDH and MDA contents, inflammation, apoptosis, but increased proliferation, SOD content, cAMP expression, and extents of PKA and cAMP responsive element binding protein (CREB) phosphorylation in skeletal muscle cells of I/R injury.	Sevoflurane	0-11	cAMP responsive element binding protein 1	Mus musculus	200-239
33998633-11	2021	Furthermore, HT treatment increased the expression of hippocampal brain-derived neurotrophic factor (BDNF), phosphorylated tropomyosin receptor kinase B (p-TrkB), and phosphorylated c-AMP response element binding protein (p-CREB) compared with the untreated CUMS group.	3,4-dihydroxyphenylethanol	13-15	cAMP responsive element binding protein 1	Mus musculus	224-228
34054847-7	2021	Surprisingly, treatment with Sildenafil inhibited nitrosative stress and augmented the levels of LC3, beclin-1, ATG5, p-CREB and BDNF and decreased mTOR levels, as well as augmented p-AMPK.	Sildenafil Citrate	29-39	cAMP responsive element binding protein 1	Mus musculus	120-124
34054847-8	2021	In conclusion, we propose that Sildenafil alleviates EAE by activating autophagy via the eNOS-NO-AMPK-mTOR-LC3-beclin1-ATG5 and eNOS-NO-AMPK-mTOR-CREB-BDNF pathways in the spinal cord.	Sildenafil Citrate	31-41	cAMP responsive element binding protein 1	Mus musculus	146-150
33982674-7	2021	Sevoflurane treatment or silencing RASD1 reduced RASD1 expression, CK, LDH and MDA contents, inflammation, apoptosis, but increased proliferation, SOD content, cAMP expression, and extents of PKA and cAMP responsive element binding protein (CREB) phosphorylation in skeletal muscle cells of I/R injury.	Sevoflurane	0-11	cAMP responsive element binding protein 1	Mus musculus	241-245
34007230-11	2021	The expression levels of p-ERK1/2/t-ERK1/2, p-CREB/t-CREB, PGC-1alpha, FNDC5, and BDNF were increased after PNU-282987 injection.	PNU-282987	108-118	cAMP responsive element binding protein 1	Mus musculus	46-50
34007230-11	2021	The expression levels of p-ERK1/2/t-ERK1/2, p-CREB/t-CREB, PGC-1alpha, FNDC5, and BDNF were increased after PNU-282987 injection.	PNU-282987	108-118	cAMP responsive element binding protein 1	Mus musculus	53-57
33986623-7	2021	Gene expression levels of brain-derived neurotrophic factor (Bdnf) and cAMP-responsive element-binding protein (Creb1) were measured using real-time polymerase chain reaction.	Cyclic AMP	71-75	cAMP responsive element binding protein 1	Mus musculus	112-117
33957303-11	2021	Akin to the gene expression pattern, gluconeogenesis from AAs was synergistically induced by glucagon and corticosterone in a CREB- and GR-dependent manner.	Corticosterone	106-120	cAMP responsive element binding protein 1	Mus musculus	126-130
33961853-0	2021	Ferulic acid positively modulates the inflammatory response to septic liver injury through the GSK-3beta/NF-kappaB/CREB pathway.	ferulic acid	0-12	cAMP responsive element binding protein 1	Mus musculus	115-119
33609567-10	2021	Suvorexant decreased morphine-enhanced levels of CREB and p-ERK proteins but did not affect the expression of NMDA and AMPA proteins compared to the morphine group.	Morphine	21-29	cAMP responsive element binding protein 1	Mus musculus	49-53
33911050-8	2021	Moreover, PAP inhibited nuclear factor-kappaB (NF-kappaB) and enhanced cAMP-response element binding protein (CREB) activity in the SN of MPTP/LPS mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	138-142	cAMP responsive element binding protein 1	Mus musculus	110-114
33515696-4	2021	With cell culture experiments and animal studies, our results showed that miR-27 was coordinately regulated by insulin, CREB, and Hippo signalings.	mir-27	74-80	cAMP responsive element binding protein 1	Mus musculus	120-124
33515696-5	2021	First, miR-27 was upregulated in palmitate-treated cells and high fat diet-fed mouse livers, both of which exhibited insulin resistance and increased CREB expression.	mir-27	7-13	cAMP responsive element binding protein 1	Mus musculus	150-154
33515696-5	2021	First, miR-27 was upregulated in palmitate-treated cells and high fat diet-fed mouse livers, both of which exhibited insulin resistance and increased CREB expression.	Palmitates	33-42	cAMP responsive element binding protein 1	Mus musculus	150-154
33515696-6	2021	Second, miR-27 was peaked in mouse liver at post-absorptive phase when CREB activity was increased.	mir-27	8-14	cAMP responsive element binding protein 1	Mus musculus	71-75
33515696-7	2021	Also, miR-27 was increased rapidly in insulin-treated cell lines when CREB activity was decreased.	mir-27	6-12	cAMP responsive element binding protein 1	Mus musculus	70-74
33515696-8	2021	Third, miR-27 was downregulated in cultured cells when CREB was decreased by siRNA or metformin treatment.	mir-27	7-13	cAMP responsive element binding protein 1	Mus musculus	55-59
33515696-8	2021	Third, miR-27 was downregulated in cultured cells when CREB was decreased by siRNA or metformin treatment.	Metformin	86-95	cAMP responsive element binding protein 1	Mus musculus	55-59
33515696-9	2021	In contrast, miR-27 was upregulated when CREB was activated by Forskolin.	mir-27	13-19	cAMP responsive element binding protein 1	Mus musculus	41-45
33515696-9	2021	In contrast, miR-27 was upregulated when CREB was activated by Forskolin.	Colforsin	63-72	cAMP responsive element binding protein 1	Mus musculus	41-45
33515696-10	2021	Fourth, miR-27 was repressed by Hippo signaling in a CREB-independent manner: miR-27 was reduced in cells at full confluence but was inhibited in cells transfected with siRNA against Lats2 and Nf2, which were two positive regulators of Hippo signaling.	mir-27	8-14	cAMP responsive element binding protein 1	Mus musculus	53-57
33874954-14	2021	There was a significant increase in the phosphorylation of STAT3, CREB, and Akt1 with 4R treatment in the WT mouse hippocampus following LPS exposure.	4r	86-88	cAMP responsive element binding protein 1	Mus musculus	66-70
33911138-9	2021	Studies of mice"s hippocampi revealed that the response of afzelin was accountable for the restoration of the cholinergic systems and molecular signal transduction via CREB-BDNF pathways.	afzelin	59-66	cAMP responsive element binding protein 1	Mus musculus	168-172
33911138-10	2021	In conclusion, the central administration of afzelin leads to improved neurocognitive and neuroprotective effects on synaptic plasticity and behaviors partly through the increase in CREB-BDNF signaling.	afzelin	45-52	cAMP responsive element binding protein 1	Mus musculus	182-186
33986729-7	2021	In the primary hepatocytes, ADP activated the cAMP/PKA/CREB signaling pathway, which was blocked by the antagonist (2211) of the ADP receptor P2Y13.	Adenosine Diphosphate	28-31	cAMP responsive element binding protein 1	Mus musculus	55-59
33986729-7	2021	In the primary hepatocytes, ADP activated the cAMP/PKA/CREB signaling pathway, which was blocked by the antagonist (2211) of the ADP receptor P2Y13.	Cyclic AMP	46-50	cAMP responsive element binding protein 1	Mus musculus	55-59
33986729-13	2021	One of the potential pathways involves activation of the P2Y13/cAMP/PKA/CREB signaling pathway in hepatocytes and the indirect pathway may involve induction of the gluconeogenic hormones.	Cyclic AMP	63-67	cAMP responsive element binding protein 1	Mus musculus	72-76
33935701-10	2021	EEFE significantly reversed Abeta-induced suppression of cAMP response element-binding protein (CREB) phosphorylation and brain-derived neurotrophic factor (BDNF) expression, indicating neuroprotection was mediated by the CREB/BDNF signaling.	eefe	0-4	cAMP responsive element binding protein 1	Mus musculus	57-94
33935701-10	2021	EEFE significantly reversed Abeta-induced suppression of cAMP response element-binding protein (CREB) phosphorylation and brain-derived neurotrophic factor (BDNF) expression, indicating neuroprotection was mediated by the CREB/BDNF signaling.	eefe	0-4	cAMP responsive element binding protein 1	Mus musculus	96-100
33935701-10	2021	EEFE significantly reversed Abeta-induced suppression of cAMP response element-binding protein (CREB) phosphorylation and brain-derived neurotrophic factor (BDNF) expression, indicating neuroprotection was mediated by the CREB/BDNF signaling.	eefe	0-4	cAMP responsive element binding protein 1	Mus musculus	222-226
33833356-6	2021	Interestingly, FLX re-exposure in adulthood reversed the enduring FLX-induced anxiety-related responses across all behavioral tasks, while restoring ERK2-CREB-proBDNF markers to control levels and increasing mBDNF within the prefrontal cortex, but not the hippocampus.	Fluoxetine	15-18	cAMP responsive element binding protein 1	Mus musculus	154-158
33837202-5	2021	Pharmacological and genetic approaches demonstrate that adenosine acts upon the circadian clockwork via adenosine A1/A2A receptor signalling through the activation of the Ca2+ -ERK-AP-1 and CREB/CRTC1-CRE pathways to regulate the clock genes Per1 and Per2.	Adenosine	56-65	cAMP responsive element binding protein 1	Mus musculus	190-194
33917915-0	2021	Protocatechuic Aldehyde Inhibits alpha-MSH-Induced Melanogenesis in B16F10 Melanoma Cells via PKA/CREB-Associated MITF Downregulation.	Aldehydes	15-23	cAMP responsive element binding protein 1	Mus musculus	98-102
33917915-8	2021	In addition, PA decreased MITF expression levels by inhibiting phosphorylation of cAMP response element-binding protein (CREB) and cAMP-dependent protein kinase A (PKA).	protocatechualdehyde	13-15	cAMP responsive element binding protein 1	Mus musculus	82-119
33917915-8	2021	In addition, PA decreased MITF expression levels by inhibiting phosphorylation of cAMP response element-binding protein (CREB) and cAMP-dependent protein kinase A (PKA).	protocatechualdehyde	13-15	cAMP responsive element binding protein 1	Mus musculus	121-125
33917915-8	2021	In addition, PA decreased MITF expression levels by inhibiting phosphorylation of cAMP response element-binding protein (CREB) and cAMP-dependent protein kinase A (PKA).	Cyclic AMP	82-86	cAMP responsive element binding protein 1	Mus musculus	121-125
33846709-1	2021	Cyclic adenosine monophosphate responsive element-binding protein-1 (CREB1)-regulated transcription coactivator-1 (CRTC1) is a cytoplasmic coactivator that translocates to the nucleus in response to cyclic adenosine monophosphate.	Adenosine	7-16	cAMP responsive element binding protein 1	Mus musculus	69-74
33846709-1	2021	Cyclic adenosine monophosphate responsive element-binding protein-1 (CREB1)-regulated transcription coactivator-1 (CRTC1) is a cytoplasmic coactivator that translocates to the nucleus in response to cyclic adenosine monophosphate.	Adenosine	206-215	cAMP responsive element binding protein 1	Mus musculus	69-74
33829324-8	2021	Moreover, role of cAMP/PKA/CREB signaling pathway in berberine affecting bone marrow mesenchymal stem cells (BMSCs) differentiation was clarified by enzyme-linked immunosorbent assay and western blot analysis.	Cyclic AMP	18-22	cAMP responsive element binding protein 1	Mus musculus	27-31
33829324-8	2021	Moreover, role of cAMP/PKA/CREB signaling pathway in berberine affecting bone marrow mesenchymal stem cells (BMSCs) differentiation was clarified by enzyme-linked immunosorbent assay and western blot analysis.	Berberine	53-62	cAMP responsive element binding protein 1	Mus musculus	27-31
33829324-11	2021	Furthermore, berberine promotes osteogenic and inhibits adipogenic differentiation of BMSCs via cAMP/PKA/CREB signaling.	Berberine	13-22	cAMP responsive element binding protein 1	Mus musculus	105-109
33829324-14	2021	This effect may be achieved through cAMP/PKA/CREB signaling pathway.	Cyclic AMP	36-40	cAMP responsive element binding protein 1	Mus musculus	45-49
33528752-10	2021	Fluoxetine 10 mg/kg increased CREB phosphorylation and BDNF expression in the prefrontal cortex and hippocampus.	Fluoxetine	0-10	cAMP responsive element binding protein 1	Mus musculus	30-34
32428538-0	2021	CREB-mediated Generation and Neuronal Growth Regulates the Behavioral Improvement of Geniposide in Diabetes-Associated Depression Mouse Model.	geniposide	85-95	cAMP responsive element binding protein 1	Mus musculus	0-4
33797061-6	2021	Our findings indicate that the mechanisms of neuroprotection and antioxidation of EEFE are regulated by the cholinergic system, promotion of cAMP response element-binding protein (CREB) phosphorylation, and the nuclear factor erythroid-2-related factor 2 (Nrf2)/heme oxygenase (HO)-1 signaling activation.	eefe	82-86	cAMP responsive element binding protein 1	Mus musculus	141-178
33797061-6	2021	Our findings indicate that the mechanisms of neuroprotection and antioxidation of EEFE are regulated by the cholinergic system, promotion of cAMP response element-binding protein (CREB) phosphorylation, and the nuclear factor erythroid-2-related factor 2 (Nrf2)/heme oxygenase (HO)-1 signaling activation.	eefe	82-86	cAMP responsive element binding protein 1	Mus musculus	180-184
33241493-8	2021	Our results show that FLX treatment results in long-term dysregulation of mRNA levels across numerous genes from the ERK, PI3K/AKT, and Wnt intracellular signaling pathways, along with increases of the transcription factors CREB, DeltaFosB, and Zif268.	Fluoxetine	22-25	cAMP responsive element binding protein 1	Mus musculus	224-228
32428538-7	2021	In consistent with its pro-neurogenic effects, geniposide also enhanced the activity of CREB in hippocampal tissue.	geniposide	47-57	cAMP responsive element binding protein 1	Mus musculus	88-92
32428538-8	2021	Moreover, blocking CREB activity with 666-15 significantly compromised the effects of geniposide in promotion of neurogenesis and behavioral protective effects.	geniposide	86-96	cAMP responsive element binding protein 1	Mus musculus	19-23
33841637-10	2021	Moreover, miR-340-5p bound directly to CREB1.	mir-340-5p	10-20	cAMP responsive element binding protein 1	Mus musculus	39-44
33790322-1	2021	Activating transcription factor 5 (ATF5) is a member of the cAMP response element binding protein (CREB)/ATF family of basic leucine zipper transcription factors.	Leucine	125-132	cAMP responsive element binding protein 1	Mus musculus	60-97
33790322-1	2021	Activating transcription factor 5 (ATF5) is a member of the cAMP response element binding protein (CREB)/ATF family of basic leucine zipper transcription factors.	Leucine	125-132	cAMP responsive element binding protein 1	Mus musculus	99-103
33417994-11	2021	Moreover, our results demonstrated that both MEL and RES enhanced the cholinergic system and BDNF and CREB signaling pathways in the prefrontal cortex in an AD mouse model.	Melatonin	45-48	cAMP responsive element binding protein 1	Mus musculus	102-106
33417994-11	2021	Moreover, our results demonstrated that both MEL and RES enhanced the cholinergic system and BDNF and CREB signaling pathways in the prefrontal cortex in an AD mouse model.	Resveratrol	53-56	cAMP responsive element binding protein 1	Mus musculus	102-106
33242618-13	2021	CONCLUSIONS: Crocetin has neuroprotective properties and ameliorates the effects of stress-associated brain damage by regulating the MKP-1-ERK1/2-CREB signaling and intestinal ecosystem.	crocetin	13-21	cAMP responsive element binding protein 1	Mus musculus	146-150
33727611-5	2021	Investigation of oncogenic kinase signaling showed decreased phosphorylation levels of mTOR, CREB, GSK3 and GYS1 leading to altered glycogen metabolism and formation of intracellular reactive oxygen species.	Glycogen	132-140	cAMP responsive element binding protein 1	Mus musculus	93-97
33727611-5	2021	Investigation of oncogenic kinase signaling showed decreased phosphorylation levels of mTOR, CREB, GSK3 and GYS1 leading to altered glycogen metabolism and formation of intracellular reactive oxygen species.	Reactive Oxygen Species	183-206	cAMP responsive element binding protein 1	Mus musculus	93-97
33580697-0	2021	Schisandrin B inhibits alpha-melanocyte-stimulating hormone-induced melanogenesis in B16F10 cells via downregulation of MAPK and CREB signaling pathways.	schizandrin B	0-13	cAMP responsive element binding protein 1	Mus musculus	129-133
33580697-6	2021	Moreover, Sch B modulated the phosphorylation of p38, extracellular-regulated protein kinase, c-Jun N-terminal kinase, and cAMP-response element binding protein (CREB), implying that these pathways may be involved in suppressing melanogenesis.	schizandrin B	10-15	cAMP responsive element binding protein 1	Mus musculus	123-160
33580697-6	2021	Moreover, Sch B modulated the phosphorylation of p38, extracellular-regulated protein kinase, c-Jun N-terminal kinase, and cAMP-response element binding protein (CREB), implying that these pathways may be involved in suppressing melanogenesis.	schizandrin B	10-15	cAMP responsive element binding protein 1	Mus musculus	162-166
33580697-7	2021	Furthermore, we found that Sch B decreased melanogenesis by downregulating MITF and melanogenic enzymes via MAPK and CREB pathways.	schizandrin B	27-32	cAMP responsive element binding protein 1	Mus musculus	117-121
33841637-11	2021	CREB1 overexpression reversed the impact of miR-340-5p on HCC cells.	mir-340-5p	44-54	cAMP responsive element binding protein 1	Mus musculus	0-5
32694760-8	2021	In CCD-18Co cells and RAW264.7 cells, curcumin dose-dependently activated PPARgamma and CREB, whereas PPARgamma antagonist GW9662 (1 muM) or cAMP response element (CREB) inhibitor KG-501 (10 muM) significantly decreased the boosting effect of curcumin on HGF expression.	Curcumin	38-46	cAMP responsive element binding protein 1	Mus musculus	164-168
33936858-7	2021	Redd1 reduced protein kinase A phosphorylation and suppressed cyclic adenosine monophosphate (cAMP) -responsive element-binding protein (CREB) binding to the cAMP regulatory element (CRE) in Ppargc1a-AP promoter, leading to Ppargc1a-AP inactivation.	Adenosine	69-78	cAMP responsive element binding protein 1	Mus musculus	137-141
33936858-7	2021	Redd1 reduced protein kinase A phosphorylation and suppressed cyclic adenosine monophosphate (cAMP) -responsive element-binding protein (CREB) binding to the cAMP regulatory element (CRE) in Ppargc1a-AP promoter, leading to Ppargc1a-AP inactivation.	Cyclic AMP	94-98	cAMP responsive element binding protein 1	Mus musculus	137-141
33936858-7	2021	Redd1 reduced protein kinase A phosphorylation and suppressed cyclic adenosine monophosphate (cAMP) -responsive element-binding protein (CREB) binding to the cAMP regulatory element (CRE) in Ppargc1a-AP promoter, leading to Ppargc1a-AP inactivation.	Cyclic AMP	158-162	cAMP responsive element binding protein 1	Mus musculus	137-141
33462377-8	2021	Moreover, we revealed that DL-NBP administration suppressed oxidative stress by upregulating Nrf2/HO-1 signaling, and increased brain-derived neurotrophic factor (BDNF) expression by activating PI3K/Akt/CREB signaling in the hippocampus.	3-n-butylphthalide	27-33	cAMP responsive element binding protein 1	Mus musculus	203-207
32694760-8	2021	In CCD-18Co cells and RAW264.7 cells, curcumin dose-dependently activated PPARgamma and CREB, whereas PPARgamma antagonist GW9662 (1 muM) or cAMP response element (CREB) inhibitor KG-501 (10 muM) significantly decreased the boosting effect of curcumin on HGF expression.	Curcumin	38-46	cAMP responsive element binding protein 1	Mus musculus	88-92
32694760-11	2021	Together, curcumin promotes the expression of HGF in colonic fibroblasts and macrophages by activating PPARgamma and CREB via an induction of 15d-PGJ2, and the HGF enters the lungs giving rise to an anti-PF effect.	Curcumin	10-18	cAMP responsive element binding protein 1	Mus musculus	117-121
33443506-5	2021	Moreover, walnut diets with dairy products reserved a d-galactose induced decrease of hippocampal p-ERK/ERK, p-CREB/CREB, and BDNF expression in the protein level.	Galactose	54-65	cAMP responsive element binding protein 1	Mus musculus	111-115
33682314-0	2021	Activation of CREB-mediated autophagy by thioperamide ameliorates beta-amyloid pathology and cognition in Alzheimer"s disease.	thioperamide	41-53	cAMP responsive element binding protein 1	Mus musculus	14-18
33682314-9	2021	Furthermore, inhibition of activity of CREB, H3R downstream signaling, by H89 reversed the effect of thioperamide on promoted cell viability, activated autophagic flux, and increased autophagic-lysosomal proteins expression, including Atg7, TFEB, and LAMP1, suggesting a CREB-dependent autophagic activation by thioperamide in AD.	thioperamide	101-113	cAMP responsive element binding protein 1	Mus musculus	39-43
33682314-9	2021	Furthermore, inhibition of activity of CREB, H3R downstream signaling, by H89 reversed the effect of thioperamide on promoted cell viability, activated autophagic flux, and increased autophagic-lysosomal proteins expression, including Atg7, TFEB, and LAMP1, suggesting a CREB-dependent autophagic activation by thioperamide in AD.	thioperamide	101-113	cAMP responsive element binding protein 1	Mus musculus	271-275
33682314-9	2021	Furthermore, inhibition of activity of CREB, H3R downstream signaling, by H89 reversed the effect of thioperamide on promoted cell viability, activated autophagic flux, and increased autophagic-lysosomal proteins expression, including Atg7, TFEB, and LAMP1, suggesting a CREB-dependent autophagic activation by thioperamide in AD.	thioperamide	311-323	cAMP responsive element binding protein 1	Mus musculus	39-43
33682314-10	2021	Taken together, these results suggested that H3R antagonist thioperamide improved cognitive impairment in APP/PS1 Tg mice via modulation of the CREB-mediated autophagy and lysosomal pathway, which contributed to Abeta clearance.	thioperamide	60-72	cAMP responsive element binding protein 1	Mus musculus	144-148
33545118-4	2021	In vitro data showed that EA suppressed the tyrosinase activity and melanogenesis by suppressing cAMP-mediated CREB and MITF signaling mechanisms in alpha-MSH-stimulated B16F10 cells.	Cyclic AMP	97-101	cAMP responsive element binding protein 1	Mus musculus	111-115
33125772-7	2021	Administration of AZD7545, a specific inhibitor of PDK2, prevented the OVX-induced bone loss, and reduced the phosphorylation of CREB and c-FOS, and the protein expression of NFATc1, in osteoclasts.	AZD 7545	18-25	cAMP responsive element binding protein 1	Mus musculus	129-133
33378713-5	2021	Ammonia was found to decrease mitochondrial numbers, potentially through a CaMKII-CREB-PGC1alpha-Nrf2 pathway in astroglia.	Ammonia	0-7	cAMP responsive element binding protein 1	Mus musculus	82-86
33681369-0	2021	lncRNA MALAT1 Regulates Mouse Granulosa Cell Apoptosis and 17beta-Estradiol Synthesis via Regulating miR-205/CREB1 Axis.	Estradiol	59-75	cAMP responsive element binding protein 1	Mus musculus	109-114
33681369-7	2021	Mechanistically, MALAT1 serves as a competing endogenous RNA (ceRNA) to sponge microRNA-205 (miR-205), thereby facilitating its downstream target of cyclic AMP response element- (CRE-) binding protein 1 (CREB1).	Cyclic AMP	149-159	cAMP responsive element binding protein 1	Mus musculus	204-209
33443506-5	2021	Moreover, walnut diets with dairy products reserved a d-galactose induced decrease of hippocampal p-ERK/ERK, p-CREB/CREB, and BDNF expression in the protein level.	Galactose	54-65	cAMP responsive element binding protein 1	Mus musculus	116-120
33301426-5	2021	ATP-P2X7 signaling enhanced the calcium flux-mediated phosphorylation of CREB, which further transactivated the Phgdh expression to maintain serine metabolism and LIC fates.	Calcium	32-39	cAMP responsive element binding protein 1	Mus musculus	73-77
33301426-5	2021	ATP-P2X7 signaling enhanced the calcium flux-mediated phosphorylation of CREB, which further transactivated the Phgdh expression to maintain serine metabolism and LIC fates.	Serine	141-147	cAMP responsive element binding protein 1	Mus musculus	73-77
33359577-0	2021	Perfluorooctane Sulfonate (PFOS) Disrupts Testosterone Biosynthesis via CREB/CRTC2/StAR Signaling Pathway in Leydig Cells.	perfluorooctane sulfonic acid	0-25	cAMP responsive element binding protein 1	Mus musculus	72-76
33359577-0	2021	Perfluorooctane Sulfonate (PFOS) Disrupts Testosterone Biosynthesis via CREB/CRTC2/StAR Signaling Pathway in Leydig Cells.	perfluorooctane sulfonic acid	27-31	cAMP responsive element binding protein 1	Mus musculus	72-76
33359577-6	2021	Our results demonstrated that PFOS dose-dependently decreased sperm count, testosterone level, CRTC2/StAR expression, and damaged testicular interstitium morphology, paralleled by increase in phosphorylated PKA, CREB and p38 in testes.	perfluorooctane sulfonic acid	30-34	cAMP responsive element binding protein 1	Mus musculus	212-216
33359577-7	2021	Additionally, similar to the in vivo results, PFOS significantly decreased testosterone secretion, CRTC2/StAR expression, interaction between CREB and CRTC2 and binding of CREB/CRTC2 to StAR promoter region, paralleled by increase in phosphorylated-p38, PKA, and CREB expression.	perfluorooctane sulfonic acid	46-50	cAMP responsive element binding protein 1	Mus musculus	142-146
33359577-7	2021	Additionally, similar to the in vivo results, PFOS significantly decreased testosterone secretion, CRTC2/StAR expression, interaction between CREB and CRTC2 and binding of CREB/CRTC2 to StAR promoter region, paralleled by increase in phosphorylated-p38, PKA, and CREB expression.	perfluorooctane sulfonic acid	46-50	cAMP responsive element binding protein 1	Mus musculus	172-176
33359577-7	2021	Additionally, similar to the in vivo results, PFOS significantly decreased testosterone secretion, CRTC2/StAR expression, interaction between CREB and CRTC2 and binding of CREB/CRTC2 to StAR promoter region, paralleled by increase in phosphorylated-p38, PKA, and CREB expression.	perfluorooctane sulfonic acid	46-50	cAMP responsive element binding protein 1	Mus musculus	172-176
33359577-9	2021	As such, the present study highlights a role of the CREB/CRTC2/StAR signaling pathway in PFOS-induced suppression of testosterone biosynthesis, advancing our understanding of molecular mechanisms for PFOS-induced male reproductive disorders.	perfluorooctane sulfonic acid	89-93	cAMP responsive element binding protein 1	Mus musculus	52-56
33359577-9	2021	As such, the present study highlights a role of the CREB/CRTC2/StAR signaling pathway in PFOS-induced suppression of testosterone biosynthesis, advancing our understanding of molecular mechanisms for PFOS-induced male reproductive disorders.	Testosterone	117-129	cAMP responsive element binding protein 1	Mus musculus	52-56
33359577-9	2021	As such, the present study highlights a role of the CREB/CRTC2/StAR signaling pathway in PFOS-induced suppression of testosterone biosynthesis, advancing our understanding of molecular mechanisms for PFOS-induced male reproductive disorders.	perfluorooctane sulfonic acid	200-204	cAMP responsive element binding protein 1	Mus musculus	52-56
33426650-6	2021	Moreover, melatonin increased BDNF and downstream phospho-TrkB/Akt/ERK/CREB levels.	Melatonin	10-19	cAMP responsive element binding protein 1	Mus musculus	71-75
32827659-13	2021	The results revealed that the anti-depression efficacy of ZZCD might be associated with PKA-CREB-BDNF-TrkB-PSD-95 pathway influenced by metabolic changes, verifying the pathway annotation speculation.	zzcd	58-62	cAMP responsive element binding protein 1	Mus musculus	92-96
33241977-5	2021	We report herein that increased cAMP alone can increase IL-4-dependent M2 marker expression through a PKA/C/EBPbeta/CREB dependent pathway in murine macrophages.	Cyclic AMP	32-36	cAMP responsive element binding protein 1	Mus musculus	116-120
33493990-7	2021	We further identified, under high dose fluoride, MKP-1 acted as a negative regulator of the fluoride-induced p-ERK1/2 signaling, leading to downregulation of CREB, c-myc, and Elk-1.	Fluorides	92-100	cAMP responsive element binding protein 1	Mus musculus	158-162
33226552-3	2021	Data from in vitro Neuro-2a cell line showed that treatment with 7,8-dihydroxyflavone (7,8-DHF), improved 3-nitropropionic acid (3-NP) induced neuronal death by stabilizing the loss of mitochondrial membrane potential and transiently increased the activity of cAMP-response element-binding protein (CREB) and BDNF via TrkB receptor activation.	6,7-dihydroxyflavone	65-85	cAMP responsive element binding protein 1	Mus musculus	260-297
33226552-3	2021	Data from in vitro Neuro-2a cell line showed that treatment with 7,8-dihydroxyflavone (7,8-DHF), improved 3-nitropropionic acid (3-NP) induced neuronal death by stabilizing the loss of mitochondrial membrane potential and transiently increased the activity of cAMP-response element-binding protein (CREB) and BDNF via TrkB receptor activation.	6,7-dihydroxyflavone	65-85	cAMP responsive element binding protein 1	Mus musculus	299-303
33226552-3	2021	Data from in vitro Neuro-2a cell line showed that treatment with 7,8-dihydroxyflavone (7,8-DHF), improved 3-nitropropionic acid (3-NP) induced neuronal death by stabilizing the loss of mitochondrial membrane potential and transiently increased the activity of cAMP-response element-binding protein (CREB) and BDNF via TrkB receptor activation.	6,7-dihydroxyflavone	87-94	cAMP responsive element binding protein 1	Mus musculus	260-297
33226552-3	2021	Data from in vitro Neuro-2a cell line showed that treatment with 7,8-dihydroxyflavone (7,8-DHF), improved 3-nitropropionic acid (3-NP) induced neuronal death by stabilizing the loss of mitochondrial membrane potential and transiently increased the activity of cAMP-response element-binding protein (CREB) and BDNF via TrkB receptor activation.	6,7-dihydroxyflavone	87-94	cAMP responsive element binding protein 1	Mus musculus	299-303
33226552-3	2021	Data from in vitro Neuro-2a cell line showed that treatment with 7,8-dihydroxyflavone (7,8-DHF), improved 3-nitropropionic acid (3-NP) induced neuronal death by stabilizing the loss of mitochondrial membrane potential and transiently increased the activity of cAMP-response element-binding protein (CREB) and BDNF via TrkB receptor activation.	3-nitropropionic acid	106-127	cAMP responsive element binding protein 1	Mus musculus	260-297
33226552-3	2021	Data from in vitro Neuro-2a cell line showed that treatment with 7,8-dihydroxyflavone (7,8-DHF), improved 3-nitropropionic acid (3-NP) induced neuronal death by stabilizing the loss of mitochondrial membrane potential and transiently increased the activity of cAMP-response element-binding protein (CREB) and BDNF via TrkB receptor activation.	3-nitropropionic acid	106-127	cAMP responsive element binding protein 1	Mus musculus	299-303
33226552-3	2021	Data from in vitro Neuro-2a cell line showed that treatment with 7,8-dihydroxyflavone (7,8-DHF), improved 3-nitropropionic acid (3-NP) induced neuronal death by stabilizing the loss of mitochondrial membrane potential and transiently increased the activity of cAMP-response element-binding protein (CREB) and BDNF via TrkB receptor activation.	3-nitropropionic acid	129-133	cAMP responsive element binding protein 1	Mus musculus	260-297
33226552-3	2021	Data from in vitro Neuro-2a cell line showed that treatment with 7,8-dihydroxyflavone (7,8-DHF), improved 3-nitropropionic acid (3-NP) induced neuronal death by stabilizing the loss of mitochondrial membrane potential and transiently increased the activity of cAMP-response element-binding protein (CREB) and BDNF via TrkB receptor activation.	3-nitropropionic acid	129-133	cAMP responsive element binding protein 1	Mus musculus	299-303
33268547-8	2021	This study reveals a new cAMP-dependent signaling pathway for cocaine-induced behavioral adaptations, mediated through NCS-Rapgef2/phospho-ERK activation, independently of PKA/CREB signaling.SIGNIFICANCE STATEMENT:ERK phosphorylation in dopamine D1 receptor expressing neurons exerts a pivotal role in psychostimulant-induced neuronal gene regulation and behavioral adaptation, including locomotor sensitization and drug preference in rodents.	Cyclic AMP	25-29	cAMP responsive element binding protein 1	Mus musculus	176-180
33268547-8	2021	This study reveals a new cAMP-dependent signaling pathway for cocaine-induced behavioral adaptations, mediated through NCS-Rapgef2/phospho-ERK activation, independently of PKA/CREB signaling.SIGNIFICANCE STATEMENT:ERK phosphorylation in dopamine D1 receptor expressing neurons exerts a pivotal role in psychostimulant-induced neuronal gene regulation and behavioral adaptation, including locomotor sensitization and drug preference in rodents.	Cocaine	62-69	cAMP responsive element binding protein 1	Mus musculus	176-180
33519376-8	2020	Moreover, the glucocorticoid receptor (GR) mediated the effects of CORT on the stimulation of the expression of BACE-1 and PS1 via the PKA and CREB pathways in neuroblastoma N2a cells.	Corticosterone	67-71	cAMP responsive element binding protein 1	Mus musculus	143-147
33519490-0	2020	The Selective SIK2 Inhibitor ARN-3236 Produces Strong Antidepressant-Like Efficacy in Mice via the Hippocampal CRTC1-CREB-BDNF Pathway.	ARN-3236	29-37	cAMP responsive element binding protein 1	Mus musculus	117-121
33519490-9	2020	Moreover, we demonstrated that the hippocampal CRTC1-CREB-BDNF pathway mediated the antidepressant-like efficacy of ARN-3236.	ARN-3236	116-124	cAMP responsive element binding protein 1	Mus musculus	53-57
32599136-8	2021	Our findings demonstrate that developmental alcohol exposure enhances alcohol intake during adolescence, which is associated with a decrease in the pCREB/CREB ratio in the hippocampus, prefrontal cortex and striatum, while the GluR1/GluR2 ratio showed a decrease in the hippocampus.	Alcohols	44-51	cAMP responsive element binding protein 1	Mus musculus	149-153
32599136-8	2021	Our findings demonstrate that developmental alcohol exposure enhances alcohol intake during adolescence, which is associated with a decrease in the pCREB/CREB ratio in the hippocampus, prefrontal cortex and striatum, while the GluR1/GluR2 ratio showed a decrease in the hippocampus.	Alcohols	70-77	cAMP responsive element binding protein 1	Mus musculus	149-153
32599136-12	2021	Furthermore, a diminished CREB signalling and glutamatergic neuroplasticity are proposed as underpinning neurobiological mechanisms involved in the sensitivity to alcohol reinforcing properties.	Alcohols	163-170	cAMP responsive element binding protein 1	Mus musculus	26-30
32876364-6	2021	Using C57BL/6 adolescent female and male mice (PND30) treated with ethanol (3 g/kg) on 2 consecutive days at 48-hour intervals over 2 weeks, we show that binge ethanol treatment alters the density and morphology of dendritic spines, effects that are associated with learning and memory impairments and changes in the levels of both transcription factor CREB phosphorylation and miRNAs.	Ethanol	160-167	cAMP responsive element binding protein 1	Mus musculus	353-357
33423191-7	2021	Finally, we showed that the expression of PI3K, the phosphorylation of Akt, as well as the phosphorylation of cAMP-responsive element-binding protein (CREB) were decreased in A1 after kanamycin-induced hearing loss.	Kanamycin	184-193	cAMP responsive element binding protein 1	Mus musculus	110-149
33423191-7	2021	Finally, we showed that the expression of PI3K, the phosphorylation of Akt, as well as the phosphorylation of cAMP-responsive element-binding protein (CREB) were decreased in A1 after kanamycin-induced hearing loss.	Kanamycin	184-193	cAMP responsive element binding protein 1	Mus musculus	151-155
33461175-0	2021	Intranasal treatment of lixisenatide attenuated emotional and olfactory symptoms via CREB-mediated adult neurogenesis in mouse depression model.	lixisenatide	24-36	cAMP responsive element binding protein 1	Mus musculus	85-89
33461175-9	2021	Inhibiting CREB with chemical approach decreased effects of LXT in reserving depression induced emotional and olfactory functions.	lixisenatide	60-63	cAMP responsive element binding protein 1	Mus musculus	11-15
33162095-8	2021	The research revealed that the GABAB-cyclic AMP-protein kinase A-cAMP-response element binding protein (GABAB-cAMP-PKA-CREB) signaling pathway was related to the depression-like symptoms and that levels of 5-hydroxytryptamine, norepinephrine, and dopamine in the hippocampus of mice increased after treatment with the adzuki bean sprout fermented milk.	Cyclic AMP	65-69	cAMP responsive element binding protein 1	Mus musculus	119-123
33368684-2	2021	FXR, a receptor for primary bile acids, reverses the activity of cAMP-response element binding protein (CREB) on autophagy-related genes (Atg)s and terminates autophagy in the fed state.	Bile Acids and Salts	28-38	cAMP responsive element binding protein 1	Mus musculus	65-102
33368684-2	2021	FXR, a receptor for primary bile acids, reverses the activity of cAMP-response element binding protein (CREB) on autophagy-related genes (Atg)s and terminates autophagy in the fed state.	Bile Acids and Salts	28-38	cAMP responsive element binding protein 1	Mus musculus	104-108
33368684-3	2021	GPBAR1, a receptor for secondary bile acids, exerts its genomic effects via cAMP-CREB pathway.	Bile Acids and Salts	33-43	cAMP responsive element binding protein 1	Mus musculus	81-85
33368684-3	2021	GPBAR1, a receptor for secondary bile acids, exerts its genomic effects via cAMP-CREB pathway.	Cyclic AMP	76-80	cAMP responsive element binding protein 1	Mus musculus	81-85
33368684-9	2021	BAR501 reversed the negative regulatory effects of feeding and FXR agonism on autophagy and promoted the recruitment of CREB to a CRE on the LC3 promoter.	6-ethyl-3,7-dihydroxycholan-24-ol	0-6	cAMP responsive element binding protein 1	Mus musculus	120-124
33579843-13	2021	CONCLUSION: DAla2GIP-Glu-PAL can improve cognitive behavior, synaptic plasticity, and central pathological damage in APP/PS1 mice, which might be associated with the inhibition of neuroinflammation, as well as upregulation of cAMP-/PKA/CREB signaling pathway.	Glutamic Acid	21-24	cAMP responsive element binding protein 1	Mus musculus	236-240
33162095-8	2021	The research revealed that the GABAB-cyclic AMP-protein kinase A-cAMP-response element binding protein (GABAB-cAMP-PKA-CREB) signaling pathway was related to the depression-like symptoms and that levels of 5-hydroxytryptamine, norepinephrine, and dopamine in the hippocampus of mice increased after treatment with the adzuki bean sprout fermented milk.	Cyclic AMP	110-114	cAMP responsive element binding protein 1	Mus musculus	119-123
33162095-8	2021	The research revealed that the GABAB-cyclic AMP-protein kinase A-cAMP-response element binding protein (GABAB-cAMP-PKA-CREB) signaling pathway was related to the depression-like symptoms and that levels of 5-hydroxytryptamine, norepinephrine, and dopamine in the hippocampus of mice increased after treatment with the adzuki bean sprout fermented milk.	Serotonin	206-225	cAMP responsive element binding protein 1	Mus musculus	119-123
33162095-8	2021	The research revealed that the GABAB-cyclic AMP-protein kinase A-cAMP-response element binding protein (GABAB-cAMP-PKA-CREB) signaling pathway was related to the depression-like symptoms and that levels of 5-hydroxytryptamine, norepinephrine, and dopamine in the hippocampus of mice increased after treatment with the adzuki bean sprout fermented milk.	Norepinephrine	227-241	cAMP responsive element binding protein 1	Mus musculus	119-123
33162095-8	2021	The research revealed that the GABAB-cyclic AMP-protein kinase A-cAMP-response element binding protein (GABAB-cAMP-PKA-CREB) signaling pathway was related to the depression-like symptoms and that levels of 5-hydroxytryptamine, norepinephrine, and dopamine in the hippocampus of mice increased after treatment with the adzuki bean sprout fermented milk.	Dopamine	247-255	cAMP responsive element binding protein 1	Mus musculus	119-123
33051852-0	2021	CREB Participates in Paclitaxel-Induced Neuropathic Pain Genesis Through Transcriptional Activation of Dnmt3a in Primary Sensory Neurons.	Paclitaxel	21-31	cAMP responsive element binding protein 1	Mus musculus	0-4
31926033-8	2021	Taken together, our data show that VuPAM decreases pro-inflammatory microglial activation by modulating Akt/GSK-3beta/CREB signaling.	prolyl-proline	51-54	cAMP responsive element binding protein 1	Mus musculus	118-122
33051852-3	2021	Here, we showed that systemic administration of the chemotherapeutic drug paclitaxel significantly and time-dependently increased the levels of cyclic AMP response element-binding protein (CREB) in dorsal root ganglion (DRG) neurons.	Paclitaxel	74-84	cAMP responsive element binding protein 1	Mus musculus	144-187
32754961-0	2021	Protective effect of ginsenoside Rh2 on scopolamine-induced memory deficits through regulation of cholinergic transmission, oxidative stress and the ERK-CREB-BDNF signaling pathway.	ginsenoside Rh2	21-36	cAMP responsive element binding protein 1	Mus musculus	153-157
33360346-10	2021	The expression levels of downstream proteins of 5-HT1A signaling pathway 5-HT1A, CREB, BDNF, and PKA were increased in UCMS-induced mice after URE administration, and URE also displayed an agonistic effect against 5-HT1A receptor with an EC50 value of 17.42 mug/ml.	Urea	143-146	cAMP responsive element binding protein 1	Mus musculus	81-85
32754961-0	2021	Protective effect of ginsenoside Rh2 on scopolamine-induced memory deficits through regulation of cholinergic transmission, oxidative stress and the ERK-CREB-BDNF signaling pathway.	Scopolamine	40-51	cAMP responsive element binding protein 1	Mus musculus	153-157
33044778-4	2021	FRA was also capable of increasing the expressions of protein kinase A/cAMP-response element-binding protein/brain-derived neurotrophic factor (PKA/CREB/BDNF) signaling in hippocampus.	Cyclic AMP	71-75	cAMP responsive element binding protein 1	Mus musculus	148-152
32980332-8	2020	Additionally, SKF83959 significantly promoted the elevation of brain-derived neurotrophic factor (BDNF) expression, possibly by the cAMP response element binding protein (CREB) -directed gene transcription.	SK and F 83959	14-22	cAMP responsive element binding protein 1	Mus musculus	132-169
33044778-7	2021	Finally, metadoxine (an antagonist of CREB) inhibited the antidepressant effects of FRA in tail suspension test (TST) and forced swimming test (FST) in LPS-induced mice, which also blocked the phosphorylation of CREB and the expressions of neurotransmitters and synaptic molecules.	metadoxine	9-19	cAMP responsive element binding protein 1	Mus musculus	38-42
33044778-7	2021	Finally, metadoxine (an antagonist of CREB) inhibited the antidepressant effects of FRA in tail suspension test (TST) and forced swimming test (FST) in LPS-induced mice, which also blocked the phosphorylation of CREB and the expressions of neurotransmitters and synaptic molecules.	metadoxine	9-19	cAMP responsive element binding protein 1	Mus musculus	212-216
33370547-8	2020	Taken together, our data demonstrated CaMKIV prevents palmitate-induced insulin resistance, inflammatory response, and mitochondrial dysfunction through phosphorylated CREB1 in differentiated C2C12 cells.	Palmitates	54-63	cAMP responsive element binding protein 1	Mus musculus	168-173
33443209-7	2020	In mice, intraperitoneal administration of chlorogenic acid activated the Akt1-CREB-RNF146 pathway in the brain and provided neuroprotection against both 6-OHDA and combinatorial alpha-synucleinopathy in an RNF146-dependent manner.	Chlorogenic Acid	43-59	cAMP responsive element binding protein 1	Mus musculus	79-83
33339187-9	2020	In addition, it downregulated the expression of cAMP response element-binding protein (CREB), Bruton"s tyrosine kinase (Btk) and phospholipase Cgamma2 (PLCgamma2) in RANKL-induced calcium signaling.	Calcium	180-187	cAMP responsive element binding protein 1	Mus musculus	48-85
32980332-8	2020	Additionally, SKF83959 significantly promoted the elevation of brain-derived neurotrophic factor (BDNF) expression, possibly by the cAMP response element binding protein (CREB) -directed gene transcription.	SK and F 83959	14-22	cAMP responsive element binding protein 1	Mus musculus	171-175
32453814-1	2020	BACKGROUND: We recently identified neuronal expression of farnesoid X receptor (FXR), a bile acid receptor known to impair autophagy by inhibiting cyclic adenosine monophosphate response element-binding protein (CREB), a protein whose under-functioning is linked to neuroplasticity and depression.	Bile Acids and Salts	88-97	cAMP responsive element binding protein 1	Mus musculus	212-216
33222572-7	2021	In addition, Abeta (1-42) induced a significant reduction in phospho-cAMP response element-binding protein (p-CREB) and brain-derived neurotrophic factor (BDNF) expression.	Cyclic AMP	69-73	cAMP responsive element binding protein 1	Mus musculus	110-114
33222572-10	2021	In addition, M1 mAChR antagonist dicyclomine significantly counteracted Ad-GPx-1-mediated increases in p-CREB and BDNF expression, as well as memory-enhancing effects in GPx-1 knockout mice, thus indicating that M1 mAChR might be a critical mediator for the rescue effects of Ad-GPx-1.	Dicyclomine	33-44	cAMP responsive element binding protein 1	Mus musculus	105-109
32453814-1	2020	BACKGROUND: We recently identified neuronal expression of farnesoid X receptor (FXR), a bile acid receptor known to impair autophagy by inhibiting cyclic adenosine monophosphate response element-binding protein (CREB), a protein whose under-functioning is linked to neuroplasticity and depression.	Adenosine	154-163	cAMP responsive element binding protein 1	Mus musculus	212-216
32453814-7	2020	The behavioral effects of FXR are found to be associated with changes in CREB-brain-derived neurotrophic factor (BDNF) signaling, as FXR overexpression aggravated CUS-induced reduction in BDNF levels while the use of FXR shRNA or disruption of FXR-CREB signaling reversed the CUS-induced reduction in the phosphorylated CREB and BDNF levels.	cus	163-166	cAMP responsive element binding protein 1	Mus musculus	73-77
32453814-7	2020	The behavioral effects of FXR are found to be associated with changes in CREB-brain-derived neurotrophic factor (BDNF) signaling, as FXR overexpression aggravated CUS-induced reduction in BDNF levels while the use of FXR shRNA or disruption of FXR-CREB signaling reversed the CUS-induced reduction in the phosphorylated CREB and BDNF levels.	cus	163-166	cAMP responsive element binding protein 1	Mus musculus	248-252
32645141-11	2020	CONCLUSIONS: Together, these results suggest that roflumilast not only improves learning and memory, but also attenuates depression-like behavior in AD mice, likely via PDE4B/PDE4D-mediated cAMP/CREB/BDNF signaling.	Roflumilast	50-61	cAMP responsive element binding protein 1	Mus musculus	195-199
33127851-2	2020	The family of cAMP-response element binding (CREB)-regulated transcription coactivators (CRTC)1-3 activate transcription by targeting the basic leucine zipper domain of CREB.	Leucine	144-151	cAMP responsive element binding protein 1	Mus musculus	45-49
32771670-12	2020	Treatment with ox-LDL significantly inhibited Akt phosphorylation (P < 0.05) and CREB phosphorylation induced by ATRA, EGF, and basic FGF (P < 0.05).	Tretinoin	113-117	cAMP responsive element binding protein 1	Mus musculus	81-85
33344501-4	2020	Western blot data showed that 7,3",4"-THIF inhibited alpha-MSH-induced tyrosinase, tyrosinase-related protein-1 (TYRP-1), and tyrosinase-related protein-2 (TYRP-2) expressions through the inhibition of Microphthalmia-associated transcription factor (MITF) expression and cAMP response element-binding (CREB) phosphorylation.	3',4',7-trihydroxyisoflavone	30-42	cAMP responsive element binding protein 1	Mus musculus	271-300
33344501-4	2020	Western blot data showed that 7,3",4"-THIF inhibited alpha-MSH-induced tyrosinase, tyrosinase-related protein-1 (TYRP-1), and tyrosinase-related protein-2 (TYRP-2) expressions through the inhibition of Microphthalmia-associated transcription factor (MITF) expression and cAMP response element-binding (CREB) phosphorylation.	3',4',7-trihydroxyisoflavone	30-42	cAMP responsive element binding protein 1	Mus musculus	302-306
33265983-11	2020	Our findings reveal that PEA exerts antidepressant effects by modulating the BDNF/TrkB/CREB signaling pathway in a mouse model of CORT-induced depression.	phenethylamine	25-28	cAMP responsive element binding protein 1	Mus musculus	87-91
33068864-0	2020	Hesperetin, a SIRT1 activator, inhibits hepatic inflammation via AMPK/CREB pathway.	hesperetin	0-10	cAMP responsive element binding protein 1	Mus musculus	70-74
33068864-6	2020	Mechanistically, hesperetin increases SIRT1 expression through AMPK/CREB pathway.	hesperetin	17-27	cAMP responsive element binding protein 1	Mus musculus	68-72
33112765-5	2020	Based on the mouse cell model, we firstly demonstrated that the cAMP/ protein kinase A (PKA)/ cAMP response element-binding protein (CREB) signaling pathway mediated gonadotropin-induced kisspeptin expression.	Cyclic AMP	64-68	cAMP responsive element binding protein 1	Mus musculus	94-131
33112765-5	2020	Based on the mouse cell model, we firstly demonstrated that the cAMP/ protein kinase A (PKA)/ cAMP response element-binding protein (CREB) signaling pathway mediated gonadotropin-induced kisspeptin expression.	Cyclic AMP	64-68	cAMP responsive element binding protein 1	Mus musculus	133-137
33329572-8	2020	Mechanistic studies showed that exosomal prostaglandin E2 (PGE2) produced by G-MDSCs upregulated the phosphorylation levels of GSK-3beta and CREB, which play a key role in the production of IL-10+ B cells.	Dinoprostone	41-57	cAMP responsive element binding protein 1	Mus musculus	141-145
33329572-8	2020	Mechanistic studies showed that exosomal prostaglandin E2 (PGE2) produced by G-MDSCs upregulated the phosphorylation levels of GSK-3beta and CREB, which play a key role in the production of IL-10+ B cells.	Dinoprostone	59-63	cAMP responsive element binding protein 1	Mus musculus	141-145
32815115-5	2020	Furthermore, chronic exposure to nicotine enhanced the PI3K/Akt and ERK/CREB pathways and increased BDNF expression in the DG of CaMKIV null mice.	Nicotine	33-41	cAMP responsive element binding protein 1	Mus musculus	72-76
32815115-7	2020	Both PNU-282987 and GTS-21 also enhanced the PI3K/Akt and ERK/CREB pathways and increased brain-derived neurotrophic factor (BDNF) expression in the DG of CaMKIV null mice.	N-neopentyl-N-nitrosourea	5-8	cAMP responsive element binding protein 1	Mus musculus	62-66
32815115-8	2020	Taken together, we demonstrated that chronic exposure to nicotine rescues depressive-like behavior via alpha7-type nAChR through the activation of both PI3K/Akt and ERK/CREB pathways in CaMKIV null mice.	Nicotine	57-65	cAMP responsive element binding protein 1	Mus musculus	169-173
33265983-0	2020	2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway.	phenethylamine	0-18	cAMP responsive element binding protein 1	Mus musculus	104-108
33265983-0	2020	2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway.	phenethylamine	20-23	cAMP responsive element binding protein 1	Mus musculus	104-108
33265983-0	2020	2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway.	Corticosterone	37-51	cAMP responsive element binding protein 1	Mus musculus	104-108
33265983-11	2020	Our findings reveal that PEA exerts antidepressant effects by modulating the BDNF/TrkB/CREB signaling pathway in a mouse model of CORT-induced depression.	Corticosterone	130-134	cAMP responsive element binding protein 1	Mus musculus	87-91
33238473-9	2020	In females, Cr supplementation increased CREB phosphorylation and levels of IkappaB (NF-kappaB suppressor), CaMKII, PSD-95, and high-molecular-weight amyloid beta (Abeta) species, whereas Abeta trimers were reduced.	Creatine	12-14	cAMP responsive element binding protein 1	Mus musculus	41-45
33203971-6	2020	Methamphetamine treatment inhibits Sigmar1, resulting in inactivation of the cAMP response element-binding protein (CREB), decreased expression of mitochondrial fission 1 protein (FIS1), and ultimately alteration of mitochondrial dynamics and function.	Methamphetamine	0-15	cAMP responsive element binding protein 1	Mus musculus	77-114
33203971-6	2020	Methamphetamine treatment inhibits Sigmar1, resulting in inactivation of the cAMP response element-binding protein (CREB), decreased expression of mitochondrial fission 1 protein (FIS1), and ultimately alteration of mitochondrial dynamics and function.	Methamphetamine	0-15	cAMP responsive element binding protein 1	Mus musculus	116-120
32777257-14	2020	CONCLUSION: The findings indicated that the development of behavioural sensitization to METH may be mediated by Fas and GIT1 through the MEK1-Erk1/2-CREB pathway.	Methamphetamine	88-92	cAMP responsive element binding protein 1	Mus musculus	149-153
33212816-1	2020	Signaling pathways, depending on the second messenger molecule cAMP, modulate hippocampal cell signaling via influencing transcription factors like cAMP-regulated element-binding protein (CREB) or early growth response 1 EGR1/Krox24/zif268/ZENK (EGR1).	Cyclic AMP	63-67	cAMP responsive element binding protein 1	Mus musculus	148-186
33212816-1	2020	Signaling pathways, depending on the second messenger molecule cAMP, modulate hippocampal cell signaling via influencing transcription factors like cAMP-regulated element-binding protein (CREB) or early growth response 1 EGR1/Krox24/zif268/ZENK (EGR1).	Cyclic AMP	63-67	cAMP responsive element binding protein 1	Mus musculus	188-192
33281604-0	2020	Scabronine G Methyl Ester Improves Memory-Related Behavior and Enhances Hippocampal Cell Proliferation and Long-Term Potentiation via the BDNF-CREB Pathway in Olfactory Bulbectomized Mice.	scabronine g methyl ester	0-25	cAMP responsive element binding protein 1	Mus musculus	143-147
33281604-7	2020	We found that SG-ME enhanced brain-derived neurotrophic factor and p-CREB levels in the hippocampus while p-CREB was localized in neurons, but not in astrocytes nor microglial cells.	sg-me	14-19	cAMP responsive element binding protein 1	Mus musculus	69-73
33281604-8	2020	These findings revealed the potential of SG-ME in improving memory impairments by enhancing cell proliferation and LTP via activation of the BDNF/CREB signaling pathway in neurons.	sg-me	41-46	cAMP responsive element binding protein 1	Mus musculus	146-150
32857422-7	2020	Using our powerful tool, it was first discovered that the uptake of extracellular Fe 2+ into cortex and striatum was largely mediated by cyclic adenosine monophosphate (cAMP) through CREB-related pathway in AD mouse brain.	fe 2+	82-87	cAMP responsive element binding protein 1	Mus musculus	183-187
32857422-7	2020	Using our powerful tool, it was first discovered that the uptake of extracellular Fe 2+ into cortex and striatum was largely mediated by cyclic adenosine monophosphate (cAMP) through CREB-related pathway in AD mouse brain.	Adenosine	144-153	cAMP responsive element binding protein 1	Mus musculus	183-187
32777257-10	2020	The detection of gene expression by RT-PCR indicated that METH-sensitized mice exhibited decreased levels of Fas, MEK1 and CREB and increased levels of Erk1/2 in the PFC.	Methamphetamine	58-62	cAMP responsive element binding protein 1	Mus musculus	123-127
32777257-11	2020	Western blot analysis revealed decreased Fas, GIT1, MEK1 and phosphorylated CREB levels and increased phosphorylated Erk1/2 levels in METH-sensitized mice.	Methamphetamine	134-138	cAMP responsive element binding protein 1	Mus musculus	76-80
32857422-7	2020	Using our powerful tool, it was first discovered that the uptake of extracellular Fe 2+ into cortex and striatum was largely mediated by cyclic adenosine monophosphate (cAMP) through CREB-related pathway in AD mouse brain.	Cyclic AMP	169-173	cAMP responsive element binding protein 1	Mus musculus	183-187
33030802-3	2020	This initial observation led us to determine that Prom1 deficiency inhibited cAMP response element-binding protein (CREB) activation and gluconeogenesis, but not cyclic AMP (cAMP) accumulation, in glucagon-, epinephrine-, or forskolin-treated liver tissues and primary hepatocytes, and mitigated glucagon-induced hyperglycemia.	Cyclic AMP	77-81	cAMP responsive element binding protein 1	Mus musculus	116-120
33182035-10	2020	Furthermore, THCA downregulated the levels of inducible nitric oxide (iNOS), cyclooxygenase-2 (COX-2), and leukotriene B4 (LTB4) expression, mucus production and CREB phosphorylation as well as Penh value.	thca	13-17	cAMP responsive element binding protein 1	Mus musculus	162-166
32348553-0	2020	New Synthesized Galloyl-RGD Inhibits Melanogenesis by Regulating the CREB and ERK Signaling Pathway in B16F10 Melanoma Cells.	galloyl-rgd	16-27	cAMP responsive element binding protein 1	Mus musculus	69-73
32348553-9	2020	In addition, galloyl-RGD reduces intracellular cyclic adenosine monophosphate (cAMP) levels that leads to inhibition of cAMP-responsive element binding protein (CREB) phosphorylation and activates extracellular signal-regulated kinase (ERK) expression.	galloyl-rgd	13-24	cAMP responsive element binding protein 1	Mus musculus	120-159
32348553-9	2020	In addition, galloyl-RGD reduces intracellular cyclic adenosine monophosphate (cAMP) levels that leads to inhibition of cAMP-responsive element binding protein (CREB) phosphorylation and activates extracellular signal-regulated kinase (ERK) expression.	galloyl-rgd	13-24	cAMP responsive element binding protein 1	Mus musculus	161-165
32348553-9	2020	In addition, galloyl-RGD reduces intracellular cyclic adenosine monophosphate (cAMP) levels that leads to inhibition of cAMP-responsive element binding protein (CREB) phosphorylation and activates extracellular signal-regulated kinase (ERK) expression.	Adenosine	54-63	cAMP responsive element binding protein 1	Mus musculus	120-159
32348553-9	2020	In addition, galloyl-RGD reduces intracellular cyclic adenosine monophosphate (cAMP) levels that leads to inhibition of cAMP-responsive element binding protein (CREB) phosphorylation and activates extracellular signal-regulated kinase (ERK) expression.	Adenosine	54-63	cAMP responsive element binding protein 1	Mus musculus	161-165
32348553-9	2020	In addition, galloyl-RGD reduces intracellular cyclic adenosine monophosphate (cAMP) levels that leads to inhibition of cAMP-responsive element binding protein (CREB) phosphorylation and activates extracellular signal-regulated kinase (ERK) expression.	Cyclic AMP	79-83	cAMP responsive element binding protein 1	Mus musculus	120-159
32348553-9	2020	In addition, galloyl-RGD reduces intracellular cyclic adenosine monophosphate (cAMP) levels that leads to inhibition of cAMP-responsive element binding protein (CREB) phosphorylation and activates extracellular signal-regulated kinase (ERK) expression.	Cyclic AMP	79-83	cAMP responsive element binding protein 1	Mus musculus	161-165
32348553-10	2020	These results indicate that CREB and ERK regulation by galloyl-RGD contributes to reduced melanin synthesis via degradation of microphthalmia-associated transcription factor (MITF).	galloyl-rgd	55-66	cAMP responsive element binding protein 1	Mus musculus	28-32
32348553-10	2020	These results indicate that CREB and ERK regulation by galloyl-RGD contributes to reduced melanin synthesis via degradation of microphthalmia-associated transcription factor (MITF).	Melanins	90-97	cAMP responsive element binding protein 1	Mus musculus	28-32
33121486-5	2020	Using an unbiased analysis of gene expression in the dorsal hippocampus after training in the Morris water maze or contextual fear conditioning, we discovered dysregulation of CREB, CLOCK, and BMAL1 target genes and downregulation of circadian genes in CBPKIX/KIX mice.	Water	101-106	cAMP responsive element binding protein 1	Mus musculus	176-180
32926224-9	2020	Hcyb1 also rescued corticosterone-induced decreases in both cGMP and cAMP levels, pCREB/CREB and BDNF expression.	Corticosterone	19-33	cAMP responsive element binding protein 1	Mus musculus	83-87
33033186-6	2020	These interaction interface inhibitors strongly reduce NMDA-triggered toxicity and mitochondrial dysfunction, abolish cyclic adenosine monophosphate-responsive element-binding protein (CREB) shutoff, boost gene induction, and reduce neuronal loss in mouse models of stroke and retinal degeneration.	N-Methylaspartate	55-59	cAMP responsive element binding protein 1	Mus musculus	118-183
33033186-6	2020	These interaction interface inhibitors strongly reduce NMDA-triggered toxicity and mitochondrial dysfunction, abolish cyclic adenosine monophosphate-responsive element-binding protein (CREB) shutoff, boost gene induction, and reduce neuronal loss in mouse models of stroke and retinal degeneration.	N-Methylaspartate	55-59	cAMP responsive element binding protein 1	Mus musculus	185-189
32159232-10	2020	The mechanism studies showed that PACAP selectively binds to the PAC1 receptor to attenuate palmitic acid-induced mouse spermatogenic cell (GC-1) apoptosis via the PKA/CREB/Sirt1/p53 pathway.	Palmitic Acid	92-105	cAMP responsive element binding protein 1	Mus musculus	168-172
32069074-8	2020	The interaction between MALAT1 and YAP was analyzed and CREB expression in high-glucose CFs was detected.	Glucose	80-87	cAMP responsive element binding protein 1	Mus musculus	56-60
32069074-13	2020	CREB was increased in high-glucose CFs but decreased after silencing MALAT1.	Glucose	27-34	cAMP responsive element binding protein 1	Mus musculus	0-4
32682919-0	2020	Ginsenoside Rd reverses cognitive deficits by modulating BDNF-dependent CREB pathway in chronic restraint stress mice.	Ginsenosides	0-11	cAMP responsive element binding protein 1	Mus musculus	72-76
32800853-0	2020	Activation of AMPK/aPKCzeta/CREB pathway by metformin is associated with upregulation of GDNF and dopamine.	Metformin	44-53	cAMP responsive element binding protein 1	Mus musculus	28-32
32800853-0	2020	Activation of AMPK/aPKCzeta/CREB pathway by metformin is associated with upregulation of GDNF and dopamine.	Dopamine	98-106	cAMP responsive element binding protein 1	Mus musculus	28-32
32800853-7	2020	We found that the AMPK/aPKCzeta/CREB pathway was essential for metformin-induced GDNF upregulation and TH activation.	Metformin	63-72	cAMP responsive element binding protein 1	Mus musculus	32-36
32535982-0	2020	Melatonin recovers sleep phase delayed by MK-801 through the melatonin MT2 receptor- Ca2+ -CaMKII-CREB pathway in the ventrolateral preoptic nucleus.	Melatonin	0-9	cAMP responsive element binding protein 1	Mus musculus	98-102
32535982-0	2020	Melatonin recovers sleep phase delayed by MK-801 through the melatonin MT2 receptor- Ca2+ -CaMKII-CREB pathway in the ventrolateral preoptic nucleus.	Dizocilpine Maleate	42-48	cAMP responsive element binding protein 1	Mus musculus	98-102
32535982-4	2020	In addition, our data showed that MK-801 decreased Ca2+ -related CaMKII expression and CREB phosphorylation levels in the VLPO, and MLT could rescue these intracellular impairments but not NMDAR expression levels.	Dizocilpine Maleate	34-40	cAMP responsive element binding protein 1	Mus musculus	87-91
32431006-0	2020	Dammarane sapogenins attenuates stress-induced anxiety-like behaviors by upregulating ERK/CREB/BDNF pathways.	dammarane	0-9	cAMP responsive element binding protein 1	Mus musculus	90-94
32431006-0	2020	Dammarane sapogenins attenuates stress-induced anxiety-like behaviors by upregulating ERK/CREB/BDNF pathways.	Sapogenins	10-20	cAMP responsive element binding protein 1	Mus musculus	90-94
32454171-0	2020	Anti-melanogenic effects of epigallocatechin-3-gallate (EGCG), epicatechin-3-gallate (ECG) and gallocatechin-3-gallate (GCG) via down-regulation of cAMP/CREB /MITF signaling pathway in B16F10 melanoma cells.	epigallocatechin gallate	28-54	cAMP responsive element binding protein 1	Mus musculus	153-157
32431006-5	2020	Treatment with DS significantly upregulated BDNF (brain-derived neurotrophic factor), p-CREB/CREB and p-ERK1/2/ERK1/2 protein expression in the hippocampus and prefrontal cortex of CSDS mice.	ds	15-17	cAMP responsive element binding protein 1	Mus musculus	88-92
32431006-5	2020	Treatment with DS significantly upregulated BDNF (brain-derived neurotrophic factor), p-CREB/CREB and p-ERK1/2/ERK1/2 protein expression in the hippocampus and prefrontal cortex of CSDS mice.	ds	15-17	cAMP responsive element binding protein 1	Mus musculus	93-97
32431006-6	2020	Collectively, these results suggest that DS exerts anxiolytic-like effects in CSDS model mice and the action is mediated, at least in part, by modulating the HPA (hypothalamic-pituitary-adrenal) axis and monoamine neurotransmitter levels, and via ERK/CREB/BDNF signaling pathway.	ds	41-43	cAMP responsive element binding protein 1	Mus musculus	251-255
32380246-15	2020	Casticin also decreased AChE activity in ex vivo analysis and increased the phosphorylation levels of memory-related signaling molecules, such as ERK, CREB and BDNF in the cortex.	casticin	0-8	cAMP responsive element binding protein 1	Mus musculus	151-155
32380246-16	2020	CONCLUSION: These results suggest that casticin ameliorates cholinergic blockade-induced cognitive impairment, in part, through the inhibition of AChE and the activation of the ERK-CREB-BDNF signaling pathway.	casticin	39-47	cAMP responsive element binding protein 1	Mus musculus	181-185
32899453-13	2020	The cAMP and phosphorylation of CREB were enhanced by G-1 but inhibited by G-15.	Cyclic AMP	4-8	cAMP responsive element binding protein 1	Mus musculus	32-36
32878981-4	2020	SMOC1 exerted its favorable glycemic effects by inhibiting adenosine 3",5"-cyclic monophosphate (cAMP)-cAMP-dependent protein kinase (PKA)-cAMP response element-binding protein (CREB) signaling in the liver, leading to decreased gluconeogenic gene expression and suppression of hepatic glucose output.	Adenosine	59-68	cAMP responsive element binding protein 1	Mus musculus	178-182
32878981-4	2020	SMOC1 exerted its favorable glycemic effects by inhibiting adenosine 3",5"-cyclic monophosphate (cAMP)-cAMP-dependent protein kinase (PKA)-cAMP response element-binding protein (CREB) signaling in the liver, leading to decreased gluconeogenic gene expression and suppression of hepatic glucose output.	Cyclic AMP	97-101	cAMP responsive element binding protein 1	Mus musculus	178-182
32878981-4	2020	SMOC1 exerted its favorable glycemic effects by inhibiting adenosine 3",5"-cyclic monophosphate (cAMP)-cAMP-dependent protein kinase (PKA)-cAMP response element-binding protein (CREB) signaling in the liver, leading to decreased gluconeogenic gene expression and suppression of hepatic glucose output.	Cyclic AMP	103-107	cAMP responsive element binding protein 1	Mus musculus	178-182
32878981-4	2020	SMOC1 exerted its favorable glycemic effects by inhibiting adenosine 3",5"-cyclic monophosphate (cAMP)-cAMP-dependent protein kinase (PKA)-cAMP response element-binding protein (CREB) signaling in the liver, leading to decreased gluconeogenic gene expression and suppression of hepatic glucose output.	Cyclic AMP	103-107	cAMP responsive element binding protein 1	Mus musculus	178-182
32649976-7	2020	4-PSQ was able to significantly reverse the increase in RS and corticosterone levels, as well as the decrease of CREB and BDNF expression in the cerebral structures and increase of NF-kappaB expression in the hippocampus.	4-psq	0-5	cAMP responsive element binding protein 1	Mus musculus	113-117
32535181-0	2020	Antidepressant effect of BE360, a new selective estrogen receptor modulator, activated via CREB/BDNF, Bcl-2 signaling pathways in ovariectomized mice.	be360	25-30	cAMP responsive element binding protein 1	Mus musculus	91-95
32535181-8	2020	BE360 treatment in OVX + Stress-exposed mice increased p-CREB, BDNF, and Bcl-2 expressions in the hippocampus.	be360	0-5	cAMP responsive element binding protein 1	Mus musculus	57-61
32535181-10	2020	The present study demonstrates that BE360 exerts antidepressant effects via hippocampal neurogenesis, potentially activated through CREB/BDNF, Bcl-2 signaling pathways.	be360	36-41	cAMP responsive element binding protein 1	Mus musculus	132-136
32454171-0	2020	Anti-melanogenic effects of epigallocatechin-3-gallate (EGCG), epicatechin-3-gallate (ECG) and gallocatechin-3-gallate (GCG) via down-regulation of cAMP/CREB /MITF signaling pathway in B16F10 melanoma cells.	epicatechin gallate	63-84	cAMP responsive element binding protein 1	Mus musculus	153-157
32454171-0	2020	Anti-melanogenic effects of epigallocatechin-3-gallate (EGCG), epicatechin-3-gallate (ECG) and gallocatechin-3-gallate (GCG) via down-regulation of cAMP/CREB /MITF signaling pathway in B16F10 melanoma cells.	gallocatechin gallate	31-54	cAMP responsive element binding protein 1	Mus musculus	153-157
32454171-6	2020	Moreover, GCG, EGCG, and ECG regulated the melanogenesis of B16F10 cells through the cAMP/CREB/MITF pathway.	gallocatechin gallate	10-13	cAMP responsive element binding protein 1	Mus musculus	90-94
32454171-6	2020	Moreover, GCG, EGCG, and ECG regulated the melanogenesis of B16F10 cells through the cAMP/CREB/MITF pathway.	epigallocatechin gallate	15-19	cAMP responsive element binding protein 1	Mus musculus	90-94
32454171-6	2020	Moreover, GCG, EGCG, and ECG regulated the melanogenesis of B16F10 cells through the cAMP/CREB/MITF pathway.	Cyclic AMP	85-89	cAMP responsive element binding protein 1	Mus musculus	90-94
32772437-2	2020	Here, we report that a single injection of norepinephrine (NE; 1 mg kg-1 ; s.c) attenuated the fasting-induced up-regulation of FoxO-target genes in tibialis anterior (TA) muscles by the stimulation of PKA/CREB and Akt/FoxO1 signaling pathways.	Norepinephrine	43-57	cAMP responsive element binding protein 1	Mus musculus	206-210
32474175-9	2020	The high n-3 PUFA diet also increased the mRNA expressions of BDNF, TrKB and CREB, as well as the protein concentration of pCREB as gestation progressed, compared to the other groups.	Nitrogen	9-10	cAMP responsive element binding protein 1	Mus musculus	77-81
32495040-5	2020	The CREB inhibitor KG-501 and CREB knockdown by Creb siRNA significantly suppressed primordial follicle activation, reduced pre-granulosa cell proliferation and dramatically increased oocyte apoptosis.	naphthol AS-E phosphate	19-25	cAMP responsive element binding protein 1	Mus musculus	4-8
32495040-5	2020	The CREB inhibitor KG-501 and CREB knockdown by Creb siRNA significantly suppressed primordial follicle activation, reduced pre-granulosa cell proliferation and dramatically increased oocyte apoptosis.	naphthol AS-E phosphate	19-25	cAMP responsive element binding protein 1	Mus musculus	48-52
32495040-6	2020	Western blotting results demonstrated that both the MAPK3/1 inhibitor U0126 and mTORC1 inhibitor rapamycin significantly decreased the levels of phosphorylated CREB, indicating that MAPK3/1-mTORC1 signaling is required for CREB activation.	U 0126	70-75	cAMP responsive element binding protein 1	Mus musculus	160-164
32495040-6	2020	Western blotting results demonstrated that both the MAPK3/1 inhibitor U0126 and mTORC1 inhibitor rapamycin significantly decreased the levels of phosphorylated CREB, indicating that MAPK3/1-mTORC1 signaling is required for CREB activation.	U 0126	70-75	cAMP responsive element binding protein 1	Mus musculus	223-227
32495040-6	2020	Western blotting results demonstrated that both the MAPK3/1 inhibitor U0126 and mTORC1 inhibitor rapamycin significantly decreased the levels of phosphorylated CREB, indicating that MAPK3/1-mTORC1 signaling is required for CREB activation.	Sirolimus	97-106	cAMP responsive element binding protein 1	Mus musculus	160-164
32495040-6	2020	Western blotting results demonstrated that both the MAPK3/1 inhibitor U0126 and mTORC1 inhibitor rapamycin significantly decreased the levels of phosphorylated CREB, indicating that MAPK3/1-mTORC1 signaling is required for CREB activation.	Sirolimus	97-106	cAMP responsive element binding protein 1	Mus musculus	223-227
32868905-0	2021	DL0410 ameliorates cognitive disorder in SAMP8 mice by promoting mitochondrial dynamics and the NMDAR-CREB-BDNF pathway.	DL0410	0-6	cAMP responsive element binding protein 1	Mus musculus	102-106
32735850-0	2020	The neuroprotective effect of curcumin against Cd-induced neurotoxicity and hippocampal neurogenesis promotion through CREB-BDNF signaling pathway.	Curcumin	30-38	cAMP responsive element binding protein 1	Mus musculus	119-123
32868905-7	2021	Furthermore, DL0410 administration promoted the expression of synaptic proteins (synaptophysin and PSD95) in the brain of SAMP8 mice, and upregulated the protein phosphorylation in NMDAR-CAMKII/CAMKIV-CREB pathway responsible for the synaptic plasticity.	DL0410	13-19	cAMP responsive element binding protein 1	Mus musculus	201-205
32868905-11	2021	In summary, DL0410 promotes synaptic function and neuronal survival, thus ameliorating cognitive deficits in SAMP8 mice via improved mitochondrial dynamics and increased activity of the NMDAR-CREB-BDNF pathway.	DL0410	12-18	cAMP responsive element binding protein 1	Mus musculus	192-196
32644793-0	2020	Antidepressant-like Effect of Merazin Hydrate Depends on NO/ERK by Suppressing Its Downstream NF-kappaB or Nonactivating CREB/BDNF in Mouse Hippocampus.	merazin	30-37	cAMP responsive element binding protein 1	Mus musculus	121-125
32736697-6	2020	By using inhibitors against various signaling pathways, p38, Akt, NF-kappaB, and PKA appeared potentially involved in GLN-mediated FGF21 production in AML12 cells; GLN was able to mediate activation of NF-kappaB, p38 or PKA/CREB signaling.	Glucosamine	118-121	cAMP responsive element binding protein 1	Mus musculus	224-228
32736697-6	2020	By using inhibitors against various signaling pathways, p38, Akt, NF-kappaB, and PKA appeared potentially involved in GLN-mediated FGF21 production in AML12 cells; GLN was able to mediate activation of NF-kappaB, p38 or PKA/CREB signaling.	Glucosamine	164-167	cAMP responsive element binding protein 1	Mus musculus	224-228
32479857-11	2020	In conclusion, in the vHp, which is associated with emotional behavior, IMP decreased nNOS levels and activated CREB, suggesting that IMP can elicit anxiolytic effects.	Inosine Monophosphate	72-75	cAMP responsive element binding protein 1	Mus musculus	112-116
32479857-11	2020	In conclusion, in the vHp, which is associated with emotional behavior, IMP decreased nNOS levels and activated CREB, suggesting that IMP can elicit anxiolytic effects.	Inosine Monophosphate	134-137	cAMP responsive element binding protein 1	Mus musculus	112-116
32644793-5	2020	Notably, MH only reversed the expression of nNOS"s downstream NF-kappaB and not the CREB/BDNF pathway in the hippocampus, and MH"s antidepressant-like effects were prevented by Asatone (an agonist of NF-kappaB) and not H89 (an antagonist of CREB).	ASATONE	177-184	cAMP responsive element binding protein 1	Mus musculus	241-245
32765947-0	2020	Artemisinin Improved Neuronal Functions in Alzheimer"s Disease Animal Model 3xtg Mice and Neuronal Cells via Stimulating the ERK/CREB Signaling Pathway.	artemisinin	0-11	cAMP responsive element binding protein 1	Mus musculus	129-133
32806562-6	2020	In the hippocampus GLN elevated tissue cAMP concentrations and CREB phosphorylation, and upregulated the expression of BDNF, CREB5 and the BDNF receptor TrkB, but it reduced PDE4B expression.	Glucosamine	19-22	cAMP responsive element binding protein 1	Mus musculus	63-67
32806562-8	2020	Our current findings suggest that GLN can exert a cognition-enhancing function and this may act at least in part by upregulating the BDNF levels via a cAMP/PKA/CREB-dependent pathway.	Glucosamine	34-37	cAMP responsive element binding protein 1	Mus musculus	160-164
32806562-8	2020	Our current findings suggest that GLN can exert a cognition-enhancing function and this may act at least in part by upregulating the BDNF levels via a cAMP/PKA/CREB-dependent pathway.	Cyclic AMP	151-155	cAMP responsive element binding protein 1	Mus musculus	160-164
32644771-5	2020	Compound 5 significantly increased the heme oxygenase-1 (HO-1) levels and the phosphorylated cAMP response elements binding protein (p-CREB), while it down-regulated phosphodiesterase-4 B (PDE4B) expression in vitro.	Cyclic AMP	93-97	cAMP responsive element binding protein 1	Mus musculus	135-139
32689640-0	2020	miR-134-5p inhibition reduces infarct-induced cardiomyocyte apoptosis via Creb1 upregulation.	mir-134-5p	0-10	cAMP responsive element binding protein 1	Mus musculus	74-79
32346941-7	2020	ZN also rescued the ZnT3 loss-associated reduction of neurogenesis via elevation of IGF-1 and ERK/CREB activation.	Zinc	0-2	cAMP responsive element binding protein 1	Mus musculus	98-102
32974347-0	2020	Glucose Overload Inhibits Glutamatergic Synaptic Transmission: A Novel Role for CREB-Mediated Regulation of Synaptotagmins 2 and 4.	Glucose	0-7	cAMP responsive element binding protein 1	Mus musculus	80-84
32974347-3	2020	Accordingly, glucose excess negatively affected activity-dependent CREB phosphorylation and CREB-mediated mRNA expression of synaptic proteins in hippocampal primary neurons.	Glucose	13-20	cAMP responsive element binding protein 1	Mus musculus	67-71
32974347-3	2020	Accordingly, glucose excess negatively affected activity-dependent CREB phosphorylation and CREB-mediated mRNA expression of synaptic proteins in hippocampal primary neurons.	Glucose	13-20	cAMP responsive element binding protein 1	Mus musculus	92-96
32974347-4	2020	Specifically, glucose excess inhibited the activity-dependent recruitment of CREB on the regulatory sequences of synaptotagmin (SYT) 2 and 4 promoters and the expression of SYT4 protein.	Glucose	14-21	cAMP responsive element binding protein 1	Mus musculus	77-81
32848450-0	2020	Spinal N-Cadherin/CREB Signaling Contributes to Chronic Alcohol Consumption-Enhanced Postsurgical Pain.	Alcohols	56-63	cAMP responsive element binding protein 1	Mus musculus	18-22
32848450-2	2020	The aim of the present study was to investigate the role of spinal N-cadherin/CREB signaling in postsurgical pain chronicity following chronic alcohol consumption.	Alcohols	143-150	cAMP responsive element binding protein 1	Mus musculus	78-82
32848450-9	2020	Results: We observed that the chronic alcohol consumption significantly prolonged postsurgical pain and enhanced plantar incision-increased N-cadherin expression and CREB phosphorylation at the Ser133 in the spinal cord.	Alcohols	38-45	cAMP responsive element binding protein 1	Mus musculus	166-170
32848450-10	2020	Intrathecal injection of specific N-cadherin and CREB inhibitors attenuated chronic alcohol consumption-prolonged postsurgical pain.	Alcohols	84-91	cAMP responsive element binding protein 1	Mus musculus	49-53
32848450-11	2020	Conclusion: Our results suggest that spinal N-cadherin/CREB signaling is involved in chronic alcohol consumption-caused postsurgical pain chronicity.	Alcohols	93-100	cAMP responsive element binding protein 1	Mus musculus	55-59
32765947-6	2020	Western blot assay showed that artemisinin stimulated the activation of ERK/CREB signaling pathway.	artemisinin	31-42	cAMP responsive element binding protein 1	Mus musculus	76-80
32765947-10	2020	These data put together suggested that artemisinin has the potential to protect neuronal cells in vitro as well as in vivo animal model 3xTg mice via, at least in part, the activation of the ERK/CREB pathway.	artemisinin	39-50	cAMP responsive element binding protein 1	Mus musculus	195-199
32774360-9	2020	In addition, hyperoside inhibited the activation of ERK pathway and phosphorylation of its downstream transcriptional factor CREB, as well as the miRNA-34a expression.	hyperoside	13-23	cAMP responsive element binding protein 1	Mus musculus	125-129
32774360-11	2020	Conclusion: Our cumulative results suggested that hyperoside inhibits the proliferation of SV40-MES13 cells through the suppression of the ERK/CREB/miRNA-34a signaling pathway, which provides new insight to the current investigation on therapeutic strategies for diabetic nephropathy.	hyperoside	50-60	cAMP responsive element binding protein 1	Mus musculus	143-147
32658632-12	2020	In diabetic mice induced by STZ, LIF could down-regulate the protein level of VEGF, HIF-1alpha, p-CaMKII and p-CREB, which suggest that LIF could inhibit retinal angiogenesis in diabetic mice.	Streptozocin	28-31	cAMP responsive element binding protein 1	Mus musculus	111-115
32553391-0	2020	GPR39 protects against corticosterone-induced neuronal injury in hippocampal cells through the CREB-BDNF signaling pathway.	Corticosterone	23-37	cAMP responsive element binding protein 1	Mus musculus	95-99
32754030-9	2020	BTS mice showed increased expression of brain-derived neurotrophic factor (BDNF) and a higher ratio of phosphorylated cAMP response element-binding protein (p-CREB) to CREB (p-CREB/CREB) in the hippocampus.	Cyclic AMP	118-122	cAMP responsive element binding protein 1	Mus musculus	159-163
32251674-0	2020	DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust anti-inflammation through regulating PKA-CREB signaling.	dc591017	0-8	cAMP responsive element binding protein 1	Mus musculus	102-106
32251674-6	2020	We demonstrated herein that DC591017 suppressed the inflammatory responses of macrophages and DCs through promoting cAMP-dependent PKA-CREB signaling.	dc591017	28-36	cAMP responsive element binding protein 1	Mus musculus	135-139
32251674-6	2020	We demonstrated herein that DC591017 suppressed the inflammatory responses of macrophages and DCs through promoting cAMP-dependent PKA-CREB signaling.	Cyclic AMP	116-120	cAMP responsive element binding protein 1	Mus musculus	135-139
32251674-10	2020	Consistently, DC591017 decreased expression of PDE4 isoforms and subsequently regulated PKA-CREB and NF-kappaB signaling.	dc591017	14-22	cAMP responsive element binding protein 1	Mus musculus	92-96
32133639-3	2020	Previously, we found out that oleanolic acid, which is similar chemical structure with maslinic acid, ameliorates cognitive impairment through the activation of tropomyosin receptor kinase (TrkB)-extracellular-signal-regulated kinase (ERK)-cAMP response element-binding protein (CREB) phosphorylation and increased levels of brain-derived neurotrophic factor (BDNF).	Oleanolic Acid	30-44	cAMP responsive element binding protein 1	Mus musculus	279-283
32133639-6	2020	In addition, we also observed that ERK-CREB, phosphoinositide 3-kinase (PI3K) and protein kinase B (Akt) phosphorylation levels were increased by maslinic acid administration in the mouse hippocampus.	maslinic acid	146-159	cAMP responsive element binding protein 1	Mus musculus	39-43
32553391-8	2020	Compared with the control group, the mRNA and protein levels of GPR39, CREB and BDNF were significantly increased, and the mRNA and protein levels of CREB and BDNF were significantly decreased after 50 muM zinc sulfate treatment for 6 h. CONCLUSIONS: GPR39 may play a neuroprotective role in CORT-induced cell injury via the improvement of CREB-BDNF expression, by inhibiting pro-apoptotic proteins and by upregulating anti-apoptotic proteins.	Zinc Sulfate	206-218	cAMP responsive element binding protein 1	Mus musculus	71-75
32553391-8	2020	Compared with the control group, the mRNA and protein levels of GPR39, CREB and BDNF were significantly increased, and the mRNA and protein levels of CREB and BDNF were significantly decreased after 50 muM zinc sulfate treatment for 6 h. CONCLUSIONS: GPR39 may play a neuroprotective role in CORT-induced cell injury via the improvement of CREB-BDNF expression, by inhibiting pro-apoptotic proteins and by upregulating anti-apoptotic proteins.	Zinc Sulfate	206-218	cAMP responsive element binding protein 1	Mus musculus	150-154
32553391-8	2020	Compared with the control group, the mRNA and protein levels of GPR39, CREB and BDNF were significantly increased, and the mRNA and protein levels of CREB and BDNF were significantly decreased after 50 muM zinc sulfate treatment for 6 h. CONCLUSIONS: GPR39 may play a neuroprotective role in CORT-induced cell injury via the improvement of CREB-BDNF expression, by inhibiting pro-apoptotic proteins and by upregulating anti-apoptotic proteins.	Zinc Sulfate	206-218	cAMP responsive element binding protein 1	Mus musculus	150-154
32304763-11	2020	In C57BL/6 mice, 17-AAG decreased morphine-induced acute anti-nociception in the hot plate test, with an increase in phosphorylated PKA and phosphorylated JNK and a decrease in phosphorylated CREB and phosphorylated ERK in murine brains.	tanespimycin	17-23	cAMP responsive element binding protein 1	Mus musculus	192-196
32304763-11	2020	In C57BL/6 mice, 17-AAG decreased morphine-induced acute anti-nociception in the hot plate test, with an increase in phosphorylated PKA and phosphorylated JNK and a decrease in phosphorylated CREB and phosphorylated ERK in murine brains.	Morphine	34-42	cAMP responsive element binding protein 1	Mus musculus	192-196
32170675-7	2020	Furthermore, Bex treatment also rescued the decrease in the expression of BDNF, and inhibition of CREB/BDNF/ERK pathway, and improved the expression of synaptic related protein in CORT-induced mice.	Bexarotene	13-16	cAMP responsive element binding protein 1	Mus musculus	98-102
32532293-13	2020	Immunostaining analysis demonstrated that MS accelerated the development of endometriosis likely through decreased dopamine receptor D2 (DRD2) expression and activation of the ADRB2/cAMP-response element binding protein (CREB) signaling pathway, leading to increased angiogenesis and progression of endometriotic lesions.	Cyclic AMP	182-186	cAMP responsive element binding protein 1	Mus musculus	221-225
32605164-4	2020	In the in vitro assay, cyclic AMP (cAMP) response element binding protein 1 (CREB1) was markedly phosphorylated (p-CREB1), and the CREB-binding protein (CBP) was recruited to p-CREB-1 in response to two or three cold stimulations.	Cyclic AMP	23-33	cAMP responsive element binding protein 1	Mus musculus	77-82
32605164-4	2020	In the in vitro assay, cyclic AMP (cAMP) response element binding protein 1 (CREB1) was markedly phosphorylated (p-CREB1), and the CREB-binding protein (CBP) was recruited to p-CREB-1 in response to two or three cold stimulations.	Cyclic AMP	23-33	cAMP responsive element binding protein 1	Mus musculus	115-120
32605164-4	2020	In the in vitro assay, cyclic AMP (cAMP) response element binding protein 1 (CREB1) was markedly phosphorylated (p-CREB1), and the CREB-binding protein (CBP) was recruited to p-CREB-1 in response to two or three cold stimulations.	Cyclic AMP	23-33	cAMP responsive element binding protein 1	Mus musculus	177-183
32605164-4	2020	In the in vitro assay, cyclic AMP (cAMP) response element binding protein 1 (CREB1) was markedly phosphorylated (p-CREB1), and the CREB-binding protein (CBP) was recruited to p-CREB-1 in response to two or three cold stimulations.	Cyclic AMP	35-39	cAMP responsive element binding protein 1	Mus musculus	77-82
32605164-4	2020	In the in vitro assay, cyclic AMP (cAMP) response element binding protein 1 (CREB1) was markedly phosphorylated (p-CREB1), and the CREB-binding protein (CBP) was recruited to p-CREB-1 in response to two or three cold stimulations.	Cyclic AMP	35-39	cAMP responsive element binding protein 1	Mus musculus	115-120
32605164-4	2020	In the in vitro assay, cyclic AMP (cAMP) response element binding protein 1 (CREB1) was markedly phosphorylated (p-CREB1), and the CREB-binding protein (CBP) was recruited to p-CREB-1 in response to two or three cold stimulations.	Cyclic AMP	35-39	cAMP responsive element binding protein 1	Mus musculus	177-183
32605164-5	2020	In a reporter assay with the cAMP-responsive element, the signals significantly increased after two to three cold stimulations at 4  C. In the ex vivo study, CREB-targeting genes were significantly upregulated following two or three cold stimulations.	Cyclic AMP	29-33	cAMP responsive element binding protein 1	Mus musculus	158-162
32452680-0	2020	Neuroprotective function of a novel hexapeptide QMDDQ from shrimp via activation of PKA/CREB/BNDF signaling pathway and its structure-activity relationship.	phenylalanyl-glycyl-histidyl-statyl-alanyl-phenylalanine methyl ester	36-47	cAMP responsive element binding protein 1	Mus musculus	88-92
32452680-0	2020	Neuroprotective function of a novel hexapeptide QMDDQ from shrimp via activation of PKA/CREB/BNDF signaling pathway and its structure-activity relationship.	bndf	93-97	cAMP responsive element binding protein 1	Mus musculus	88-92
32452680-5	2020	The peptides showed neuroprotective ability due to activating the anti-apoptosis and PKA/CREB/BNDF signaling pathway.	bndf	94-98	cAMP responsive element binding protein 1	Mus musculus	89-93
32188968-7	2020	Furthermore, we find that SAHA prevents SD-mediated epigenetic changes by upregulating histone acetylation, hence preserving the ERK-cAMP-responsive element-binding protein (CREB)/CREB-binding protein-brain-derived neurotrophic factor pathway in the hippocampus.	Vorinostat	26-30	cAMP responsive element binding protein 1	Mus musculus	129-172
31978378-3	2020	A growing body of research shows that the activation of the NO signaling pathway leading to the phosphorylation of the transcription factor cyclic adenine monophosphate responsive element binding protein (CREB) (so-called NO/cGMP/PKG/CREB signaling pathway) ameliorates altered neuroplasticity and memory deficits in AD animal models.	Adenine	140-168	cAMP responsive element binding protein 1	Mus musculus	205-209
31978378-3	2020	A growing body of research shows that the activation of the NO signaling pathway leading to the phosphorylation of the transcription factor cyclic adenine monophosphate responsive element binding protein (CREB) (so-called NO/cGMP/PKG/CREB signaling pathway) ameliorates altered neuroplasticity and memory deficits in AD animal models.	Adenine	140-168	cAMP responsive element binding protein 1	Mus musculus	234-238
31978378-3	2020	A growing body of research shows that the activation of the NO signaling pathway leading to the phosphorylation of the transcription factor cyclic adenine monophosphate responsive element binding protein (CREB) (so-called NO/cGMP/PKG/CREB signaling pathway) ameliorates altered neuroplasticity and memory deficits in AD animal models.	3'-guanylic acid	225-229	cAMP responsive element binding protein 1	Mus musculus	205-209
31978378-3	2020	A growing body of research shows that the activation of the NO signaling pathway leading to the phosphorylation of the transcription factor cyclic adenine monophosphate responsive element binding protein (CREB) (so-called NO/cGMP/PKG/CREB signaling pathway) ameliorates altered neuroplasticity and memory deficits in AD animal models.	3'-guanylic acid	225-229	cAMP responsive element binding protein 1	Mus musculus	234-238
31978378-6	2020	The ability of PDE5 inhibitors to interfere with the NO/cGMP/PKG/CREB signaling pathway by increasing the levels of cGMP has prompted the hypothesis that PDE5 inhibition might be used as an effective therapeutic strategy for the treatment of AD.	3'-guanylic acid	116-120	cAMP responsive element binding protein 1	Mus musculus	65-69
32488127-6	2021	We found that the expression and phosphorylation of CaMKIIbeta, ERK1/2, CREB, and NF-kappaB were inhibited by ketamine.	Ketamine	110-118	cAMP responsive element binding protein 1	Mus musculus	72-76
32488127-8	2021	Our study indicates that inhibition of CaMKIIbeta-ERK1/2-CREB/NF-kappaB signaling may mediate chronic ketamine use-associated cognitive impairments by restraining synaptic signaling.	Ketamine	102-110	cAMP responsive element binding protein 1	Mus musculus	57-61
32188968-7	2020	Furthermore, we find that SAHA prevents SD-mediated epigenetic changes by upregulating histone acetylation, hence preserving the ERK-cAMP-responsive element-binding protein (CREB)/CREB-binding protein-brain-derived neurotrophic factor pathway in the hippocampus.	Vorinostat	26-30	cAMP responsive element binding protein 1	Mus musculus	174-178
32084452-7	2020	Exclusively ligstroside increased mRNA expression of SIRT1, CREB1, complex I, and GPx1.	ligstroside	12-23	cAMP responsive element binding protein 1	Mus musculus	60-65
32302594-3	2020	Oxytocin (OXT) secretion and the subsequent cAMP-responsive element-binding (CREB) phosphorylation are involved in proconvulsant effects of sildenafil in experimental models.	Sildenafil Citrate	140-150	cAMP responsive element binding protein 1	Mus musculus	44-75
32350920-0	2020	Prostaglandin E2 confers protection against diabetic coronary atherosclerosis by stimulating M2 macrophage polarization via the activation of the CREB/BDNF/TrkB signaling pathway.	Dinoprostone	0-16	cAMP responsive element binding protein 1	Mus musculus	146-150
32350920-11	2020	PGE2 stimulated M2 macrophage polarization by inducing KLF4 via the activation of the CREB/BDNF/TrkB signaling pathway.	Dinoprostone	0-4	cAMP responsive element binding protein 1	Mus musculus	86-90
32350920-12	2020	This study demonstrates that PGE2 promotes M2 macrophage polarization by activating the CREB/BDNF/TrkB signaling pathway, thus alleviating DMAS.	Dinoprostone	29-33	cAMP responsive element binding protein 1	Mus musculus	88-92
32350920-12	2020	This study demonstrates that PGE2 promotes M2 macrophage polarization by activating the CREB/BDNF/TrkB signaling pathway, thus alleviating DMAS.	N-myristoyl-alaninol	139-143	cAMP responsive element binding protein 1	Mus musculus	88-92
32302594-3	2020	Oxytocin (OXT) secretion and the subsequent cAMP-responsive element-binding (CREB) phosphorylation are involved in proconvulsant effects of sildenafil in experimental models.	Sildenafil Citrate	140-150	cAMP responsive element binding protein 1	Mus musculus	77-81
32194081-16	2020	EZH2 expression was up-regulated but ANGPTL4 and CREB1 expression were down-regulated in DSS-treated mice.	dss	89-92	cAMP responsive element binding protein 1	Mus musculus	49-54
32035879-0	2020	Dracocephalum moldavica attenuates scopolamine-induced cognitive impairment through activation of hippocampal ERK-CREB signaling in mice.	Scopolamine	35-46	cAMP responsive element binding protein 1	Mus musculus	114-118
33209194-8	2020	Moreover, chrysin caused a reduction of formalin-induced up-regulated spinal p-CREB level, which was also reversed by i.t.	Formaldehyde	40-48	cAMP responsive element binding protein 1	Mus musculus	79-83
33209194-12	2020	In addition, spinal opioid receptors and CREB protein appear to mediate chrysin-induced antinociception in the formalin-induced pain model.	chrysin	72-79	cAMP responsive element binding protein 1	Mus musculus	41-45
33209194-12	2020	In addition, spinal opioid receptors and CREB protein appear to mediate chrysin-induced antinociception in the formalin-induced pain model.	Formaldehyde	111-119	cAMP responsive element binding protein 1	Mus musculus	41-45
32335808-0	2020	TNFAIP1 Mediates Formaldehyde-Induced Neurotoxicity by Inhibiting the Akt/CREB Pathway in N2a Cells.	Formaldehyde	17-29	cAMP responsive element binding protein 1	Mus musculus	74-78
32409785-4	2020	MiR-132 is induced and reduced by low- and high salt treatment, respectively, in a p38- and ERK1/2-independent and CREB- and salt inducible kinase-dependent manner.	Salts	48-52	cAMP responsive element binding protein 1	Mus musculus	115-119
32271540-6	2020	Mechanistically, BRL-50481 administration suppressed sevoflurane-induced neurodegenerative disorders through restoring cAMP and activating cAMP/CREB signaling in the hippocampus.	3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene	17-26	cAMP responsive element binding protein 1	Mus musculus	144-148
32271540-6	2020	Mechanistically, BRL-50481 administration suppressed sevoflurane-induced neurodegenerative disorders through restoring cAMP and activating cAMP/CREB signaling in the hippocampus.	Sevoflurane	53-64	cAMP responsive element binding protein 1	Mus musculus	144-148
31987831-0	2020	Cognitive improvement and synaptic deficit attenuation by a multifunctional carbazole-based cyanine in AD mice model through regulation of Ca2+/CaMKII/CREB signaling pathway.	carbazole	76-85	cAMP responsive element binding protein 1	Mus musculus	151-155
32440145-10	2020	Conclusion: Our findings indicated that HRH3 functioned in promoting HCC survival by inactivating the cAMP/PKA/CREB pathway to downregulate CDKN1A expression.	Cyclic AMP	102-106	cAMP responsive element binding protein 1	Mus musculus	111-115
32454931-0	2020	Mulberry Fruit Prevents Diabetes and Diabetic Dementia by Regulation of Blood Glucose through Upregulation of Antioxidative Activities and CREB/BDNF Pathway in Alloxan-Induced Diabetic Mice.	Alloxan	160-167	cAMP responsive element binding protein 1	Mus musculus	139-143
32028757-10	2020	In addition, structural changes caused by stress and blocking the changes by imipramine were corelated well with altered activation and expression of synaptic plasticity-promoting molecules such as phospho-CREB, phospho-CAMKII, and PSD-95.	Imipramine	77-87	cAMP responsive element binding protein 1	Mus musculus	206-210
32028757-10	2020	In addition, structural changes caused by stress and blocking the changes by imipramine were corelated well with altered activation and expression of synaptic plasticity-promoting molecules such as phospho-CREB, phospho-CAMKII, and PSD-95.	phosphorylleucylphenylalanine	198-205	cAMP responsive element binding protein 1	Mus musculus	206-210
31987831-0	2020	Cognitive improvement and synaptic deficit attenuation by a multifunctional carbazole-based cyanine in AD mice model through regulation of Ca2+/CaMKII/CREB signaling pathway.	thionine	92-99	cAMP responsive element binding protein 1	Mus musculus	151-155
31987831-4	2020	Moreover, SLOH attenuated synaptic deficit both in vitro and in vivo by regulating the Ca2+/CaMKII/CREB signaling pathway.	sloh	10-14	cAMP responsive element binding protein 1	Mus musculus	99-103
32115365-6	2020	LH enhanced hippocampal phosphate-AMPK, brain-derived neurotrophic factor (BDNF) and phosphate-cyclic adenosine monophosphate response element-binding protein (CREB) in OBX mice.	Phosphates	85-94	cAMP responsive element binding protein 1	Mus musculus	160-164
32115365-6	2020	LH enhanced hippocampal phosphate-AMPK, brain-derived neurotrophic factor (BDNF) and phosphate-cyclic adenosine monophosphate response element-binding protein (CREB) in OBX mice.	Adenosine	102-111	cAMP responsive element binding protein 1	Mus musculus	160-164
32411005-4	2020	Olfr544 activation by its ligand, azelaic acid (AzA, 50 muM), induced mitochondrial biogenesis and autophagy in cultured skeletal myotubes by induction of cyclic adenosine monophosphate-response element binding protein (CREB)-peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha)-extracellular signal-regulated kinase-1/2 (ERK1/2) signaling axis.	azelaic acid	34-46	cAMP responsive element binding protein 1	Mus musculus	155-218
32113678-7	2020	Significantly reduced phosphorylation of cAMP-response element binding protein (CREB) in the mPFC was observed in the mice exposed to morphine after the extinction training.	Morphine	134-142	cAMP responsive element binding protein 1	Mus musculus	41-78
32113678-7	2020	Significantly reduced phosphorylation of cAMP-response element binding protein (CREB) in the mPFC was observed in the mice exposed to morphine after the extinction training.	Morphine	134-142	cAMP responsive element binding protein 1	Mus musculus	80-84
32113678-9	2020	Moreover, effects of ZL006 on the reinstatement of morphine CPP and CREB activation depended on nNOS-PSD-95 target.	4-((3,5-dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid	21-26	cAMP responsive element binding protein 1	Mus musculus	68-72
32411005-4	2020	Olfr544 activation by its ligand, azelaic acid (AzA, 50 muM), induced mitochondrial biogenesis and autophagy in cultured skeletal myotubes by induction of cyclic adenosine monophosphate-response element binding protein (CREB)-peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha)-extracellular signal-regulated kinase-1/2 (ERK1/2) signaling axis.	azelaic acid	48-51	cAMP responsive element binding protein 1	Mus musculus	155-218
32411005-4	2020	Olfr544 activation by its ligand, azelaic acid (AzA, 50 muM), induced mitochondrial biogenesis and autophagy in cultured skeletal myotubes by induction of cyclic adenosine monophosphate-response element binding protein (CREB)-peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha)-extracellular signal-regulated kinase-1/2 (ERK1/2) signaling axis.	azelaic acid	48-51	cAMP responsive element binding protein 1	Mus musculus	220-224
32411005-6	2020	Similarly, in mice, the acute subcutaneous injection of AzA induced the CREB-PGC-1alpha-ERK1/2 pathways in mouse skeletal muscle, but these activations were negated in those of Olfr544 knockout mice.	azelaic acid	56-59	cAMP responsive element binding protein 1	Mus musculus	72-76
32467879-8	2020	In transgenic AD mice, sildenafil was found to rescue deficits in CREB phosphorylation and memory, upregulate brain-derived neurotrophic factor, reduce reactive astrocytes and microglia, decrease interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha, decrease neural apoptosis, increase neurogenesis, and reduce tau hyperphosphorylation.	Sildenafil Citrate	23-33	cAMP responsive element binding protein 1	Mus musculus	66-70
32411005-4	2020	Olfr544 activation by its ligand, azelaic acid (AzA, 50 muM), induced mitochondrial biogenesis and autophagy in cultured skeletal myotubes by induction of cyclic adenosine monophosphate-response element binding protein (CREB)-peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha)-extracellular signal-regulated kinase-1/2 (ERK1/2) signaling axis.	azelaic acid	34-46	cAMP responsive element binding protein 1	Mus musculus	220-224
32303808-6	2020	Enzyme-linked immunosorbent assay (ELISA) and western blotting results showed that DEHP significantly decreased the contents of 5-HT, cAMP, GABA and Ca2+, the levels of CREB, phosphorylation of PKA, ERK1/2 and CREB, increased the levels of CaM and phosphorylation of CaMKII in P-normal and P-T2DM mice.	Diethylhexyl Phthalate	83-87	cAMP responsive element binding protein 1	Mus musculus	169-173
32490200-0	2020	Glutathione dynamics determine the therapeutic efficacy of mesenchymal stem cells for graft-versus-host disease via CREB1-NRF2 pathway.	Glutathione	0-11	cAMP responsive element binding protein 1	Mus musculus	116-121
32490200-3	2020	Genome-wide gene expression profiling and high-throughput live-cell imaging assays revealed that CREB1 enforced the GSH-recovering capacity (GRC) of MSCs through NRF2 by directly up-regulating NRF2 target genes responsible for GSH synthesis and redox cycling.	Glutathione	116-119	cAMP responsive element binding protein 1	Mus musculus	97-102
32490200-3	2020	Genome-wide gene expression profiling and high-throughput live-cell imaging assays revealed that CREB1 enforced the GSH-recovering capacity (GRC) of MSCs through NRF2 by directly up-regulating NRF2 target genes responsible for GSH synthesis and redox cycling.	Glutathione	227-230	cAMP responsive element binding protein 1	Mus musculus	97-102
32490200-6	2020	Collectively, these findings demonstrate the molecular and functional importance of the CREB1-NRF2 pathway in maintaining MSC GSH dynamics, determining therapeutic outcomes for GVHD treatment.	Glutathione	126-129	cAMP responsive element binding protein 1	Mus musculus	88-93
32303808-6	2020	Enzyme-linked immunosorbent assay (ELISA) and western blotting results showed that DEHP significantly decreased the contents of 5-HT, cAMP, GABA and Ca2+, the levels of CREB, phosphorylation of PKA, ERK1/2 and CREB, increased the levels of CaM and phosphorylation of CaMKII in P-normal and P-T2DM mice.	Diethylhexyl Phthalate	83-87	cAMP responsive element binding protein 1	Mus musculus	210-214
32303808-8	2020	The potential neurotoxicity mechanism of DEHP may be synergistically mediated by the cAMP-PKA-ERK1/2-CREB signaling and the Ca2+ signaling pathway.	Diethylhexyl Phthalate	41-45	cAMP responsive element binding protein 1	Mus musculus	101-105
32303808-8	2020	The potential neurotoxicity mechanism of DEHP may be synergistically mediated by the cAMP-PKA-ERK1/2-CREB signaling and the Ca2+ signaling pathway.	Cyclic AMP	85-89	cAMP responsive element binding protein 1	Mus musculus	101-105
32265642-0	2020	Fisetin Prevents HT22 Cells From High Glucose-Induced Neurotoxicity via PI3K/Akt/CREB Signaling Pathway.	fisetin	0-7	cAMP responsive element binding protein 1	Mus musculus	81-85
31838720-8	2020	It also markedly increased synaptic markers and cAMP response element binding (CREB) phosphorylation rates, as a consequence of a decrease in the unfolded protein response (UPR) activation through the reduction in the activation factor 4 (ATF4) levels and posterior downregulation of protein tyrosine phosphatase 1B (PTP1B).	Cyclic AMP	48-52	cAMP responsive element binding protein 1	Mus musculus	79-83
32231468-0	2020	Activation of CREB Protein With Tabersonine Attenuates STAT3 During Atherosclerosis in Apolipoprotein E-Deficient Mice.	tabersonine	32-43	cAMP responsive element binding protein 1	Mus musculus	14-18
32231468-12	2020	Moreover, cAMP-response-element-binding (CREB) expression was elevated in aortic tissue of tabersonine treatment groups, compared to the ApoE group.	tabersonine	91-102	cAMP responsive element binding protein 1	Mus musculus	10-39
32231468-12	2020	Moreover, cAMP-response-element-binding (CREB) expression was elevated in aortic tissue of tabersonine treatment groups, compared to the ApoE group.	tabersonine	91-102	cAMP responsive element binding protein 1	Mus musculus	41-45
32231468-13	2020	Conclusion: These results suggested that tabersonine ameliorates the expression of STAT-3 by activating CREB protein in atherosclerotic ApoE-deficient mice.	tabersonine	41-52	cAMP responsive element binding protein 1	Mus musculus	104-108
32050049-8	2020	Forskolin, which promotes CREB phosphorylation, increased the transcription of the Gp2 gene in Peyer"s patches.	Colforsin	0-9	cAMP responsive element binding protein 1	Mus musculus	26-30
31879858-8	2020	Doxycycline provided a significantly increase of activated CREB and BDNF in the striatal neurons, along with a down modulation of neuroinflammation, which, combined, might explain the beneficial effects observed in this model.	Doxycycline	0-11	cAMP responsive element binding protein 1	Mus musculus	59-63
32302067-0	2020	beta2-adrenergic stimulation induces interleukin-6 by increasing Arid5a, a stabilizer of mRNA, through cAMP/PKA/CREB pathway in cardiac fibroblasts.	Cyclic AMP	103-107	cAMP responsive element binding protein 1	Mus musculus	112-116
32302067-7	2020	The activity of nuclear factor-kappaB (NF-kappaB) and cyclic AMP (cAMP) response element binding protein (CREB) was assessed by ELISA-like assay or Western blotting.	Cyclic AMP	54-64	cAMP responsive element binding protein 1	Mus musculus	106-110
32302067-7	2020	The activity of nuclear factor-kappaB (NF-kappaB) and cyclic AMP (cAMP) response element binding protein (CREB) was assessed by ELISA-like assay or Western blotting.	Cyclic AMP	66-70	cAMP responsive element binding protein 1	Mus musculus	106-110
32252200-12	2020	The DNA-binding activity of CREB in the saline group was (0.23+-0.07) Pu, significantly lower than (0.89+-0.23) Pu of morphine combined with naloxone group and (0.80+-0.23) Pu of morphine group (P<0.05).	Morphine	118-126	cAMP responsive element binding protein 1	Mus musculus	28-32
32252200-12	2020	The DNA-binding activity of CREB in the saline group was (0.23+-0.07) Pu, significantly lower than (0.89+-0.23) Pu of morphine combined with naloxone group and (0.80+-0.23) Pu of morphine group (P<0.05).	Naloxone	141-149	cAMP responsive element binding protein 1	Mus musculus	28-32
32252200-12	2020	The DNA-binding activity of CREB in the saline group was (0.23+-0.07) Pu, significantly lower than (0.89+-0.23) Pu of morphine combined with naloxone group and (0.80+-0.23) Pu of morphine group (P<0.05).	Morphine	179-187	cAMP responsive element binding protein 1	Mus musculus	28-32
32252200-13	2020	While the CREB DNA binding activity of morphine combined with compound matrine injection (300 mg/kg) group was (0.79+-0.21) Pu, implicated that compound matrine had marginal effect on the DNA-binding activity of CREB (P>0.05).	Morphine	39-47	cAMP responsive element binding protein 1	Mus musculus	10-14
32252200-13	2020	While the CREB DNA binding activity of morphine combined with compound matrine injection (300 mg/kg) group was (0.79+-0.21) Pu, implicated that compound matrine had marginal effect on the DNA-binding activity of CREB (P>0.05).	Morphine	39-47	cAMP responsive element binding protein 1	Mus musculus	212-216
32252200-13	2020	While the CREB DNA binding activity of morphine combined with compound matrine injection (300 mg/kg) group was (0.79+-0.21) Pu, implicated that compound matrine had marginal effect on the DNA-binding activity of CREB (P>0.05).	matrine	71-78	cAMP responsive element binding protein 1	Mus musculus	10-14
32252200-13	2020	While the CREB DNA binding activity of morphine combined with compound matrine injection (300 mg/kg) group was (0.79+-0.21) Pu, implicated that compound matrine had marginal effect on the DNA-binding activity of CREB (P>0.05).	matrine	71-78	cAMP responsive element binding protein 1	Mus musculus	212-216
32265642-11	2020	More importantly, the decreased phosphorylation of phosphoinositide 3 kinase (PI3K), Akt, and cAMP-response element binding protein (CREB) was rescued by fisetin treatment and that neuroprotective effect of fisetin was partially blocked by PI3K inhibitor, LY294002.	fisetin	154-161	cAMP responsive element binding protein 1	Mus musculus	94-131
32265642-11	2020	More importantly, the decreased phosphorylation of phosphoinositide 3 kinase (PI3K), Akt, and cAMP-response element binding protein (CREB) was rescued by fisetin treatment and that neuroprotective effect of fisetin was partially blocked by PI3K inhibitor, LY294002.	fisetin	154-161	cAMP responsive element binding protein 1	Mus musculus	133-137
32265642-11	2020	More importantly, the decreased phosphorylation of phosphoinositide 3 kinase (PI3K), Akt, and cAMP-response element binding protein (CREB) was rescued by fisetin treatment and that neuroprotective effect of fisetin was partially blocked by PI3K inhibitor, LY294002.	fisetin	207-214	cAMP responsive element binding protein 1	Mus musculus	94-131
32265642-11	2020	More importantly, the decreased phosphorylation of phosphoinositide 3 kinase (PI3K), Akt, and cAMP-response element binding protein (CREB) was rescued by fisetin treatment and that neuroprotective effect of fisetin was partially blocked by PI3K inhibitor, LY294002.	fisetin	207-214	cAMP responsive element binding protein 1	Mus musculus	133-137
32265642-11	2020	More importantly, the decreased phosphorylation of phosphoinositide 3 kinase (PI3K), Akt, and cAMP-response element binding protein (CREB) was rescued by fisetin treatment and that neuroprotective effect of fisetin was partially blocked by PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	256-264	cAMP responsive element binding protein 1	Mus musculus	94-131
32265642-11	2020	More importantly, the decreased phosphorylation of phosphoinositide 3 kinase (PI3K), Akt, and cAMP-response element binding protein (CREB) was rescued by fisetin treatment and that neuroprotective effect of fisetin was partially blocked by PI3K inhibitor, LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	256-264	cAMP responsive element binding protein 1	Mus musculus	133-137
32265642-12	2020	These findings indicate that fisetin has potent neuroprotective effect and prevents HG-induced neurotoxicity by activation of PI3K/Akt/CREB pathway.	fisetin	29-36	cAMP responsive element binding protein 1	Mus musculus	135-139
31972205-7	2020	Ginsenoside Rd, an active ingredient of GSE, inhibits corticosterone secretion in the cells and impedes ACTH-induced corticosterone biosynthesis through down-regulation of proteins in the cAMP/PKA/CREB signaling pathway.	ginsenoside Rd	0-14	cAMP responsive element binding protein 1	Mus musculus	197-201
31954110-11	2020	More importantly, the expression of phospho-CREB (the PKA downstream transcription factor) was decreased and phospho-p38 MAPK was increased in HG-induced podocytes, which can respectively be activated or blocked by SKF38393, 8-Bromo-CAMP (a PKA activator), NAC, and SB20380 (a p38 MAPK inhibitor).	phosphorylleucylphenylalanine	36-43	cAMP responsive element binding protein 1	Mus musculus	44-48
31972205-0	2020	Ginsenoside Rd attenuates ACTH-induced corticosterone secretion by blocking the MC2R-cAMP/PKA/CREB pathway in Y1 mouse adrenocortical cells.	ginsenoside Rd	0-14	cAMP responsive element binding protein 1	Mus musculus	94-98
31954110-11	2020	More importantly, the expression of phospho-CREB (the PKA downstream transcription factor) was decreased and phospho-p38 MAPK was increased in HG-induced podocytes, which can respectively be activated or blocked by SKF38393, 8-Bromo-CAMP (a PKA activator), NAC, and SB20380 (a p38 MAPK inhibitor).	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	215-223	cAMP responsive element binding protein 1	Mus musculus	44-48
32014436-9	2020	Moreover, we observed that SL327 treatment markedly suppressed the increased levels of p-ERK, p-CREB and BDNF in mice hippocampus induced by TSA, preventing the antidepressant effects of TSA.	tanshinone	141-144	cAMP responsive element binding protein 1	Mus musculus	96-100
32014436-10	2020	Taken together, our results suggest that the antidepressant-like effects of TSA were mediated by ERK-CREB-BDNF pathway in mice hippocampus.	tanshinone	76-79	cAMP responsive element binding protein 1	Mus musculus	101-105
31972205-7	2020	Ginsenoside Rd, an active ingredient of GSE, inhibits corticosterone secretion in the cells and impedes ACTH-induced corticosterone biosynthesis through down-regulation of proteins in the cAMP/PKA/CREB signaling pathway.	Cyclic AMP	188-192	cAMP responsive element binding protein 1	Mus musculus	197-201
31972205-9	2020	CONCLUSION: Our findings indicate that ginsenoside Rd inhibits ACTH-induced corticosterone production through blockading the MC2R-cAMP/PKA/CREB pathway in adrenocortical cells.	ginsenoside Rd	39-53	cAMP responsive element binding protein 1	Mus musculus	139-143
31972205-9	2020	CONCLUSION: Our findings indicate that ginsenoside Rd inhibits ACTH-induced corticosterone production through blockading the MC2R-cAMP/PKA/CREB pathway in adrenocortical cells.	Corticosterone	76-90	cAMP responsive element binding protein 1	Mus musculus	139-143
31743694-8	2020	Under these conditions, enhanced cAMP response element binding protein (CREB) and dopamine and cAMP-regulated phosphoprotein, 32 kDa (DARPP32) phosphorylation, significantly higher brain-derived neurotrophic factor (BDNF) and DeltaFosB, but reduced tyrosine hydroxylase (TH) and dopamine D1 receptor (D1R) protein expression were found in the NAc, DS and VTA.	Tyrosine	249-257	cAMP responsive element binding protein 1	Mus musculus	72-76
31743694-9	2020	Striatal BDNF, phospho-DARPP32 and phospho-CREB levels were significantly associated with the levels of depressive-like behavior in these mice.	phosphorylleucylphenylalanine	35-42	cAMP responsive element binding protein 1	Mus musculus	43-47
32355772-9	2020	Moreover, CIG increased the expression of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and phosphorylated cAMP-responsive element binding protein (p-CREB) in the brain of 3xTg mice.	2-AMINO-6-CHLOROPYRAZINE	10-13	cAMP responsive element binding protein 1	Mus musculus	172-176
32355772-9	2020	Moreover, CIG increased the expression of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and phosphorylated cAMP-responsive element binding protein (p-CREB) in the brain of 3xTg mice.	Cyclic AMP	129-133	cAMP responsive element binding protein 1	Mus musculus	172-176
31978253-11	2020	The decrease in the hippocampal ratio of pERK/ERK, pCAMKII/CAMKII and pCREB/CREB induced by STZ was reversed by strength exercise.	Streptozocin	92-95	cAMP responsive element binding protein 1	Mus musculus	71-75
31964464-9	2020	Taken together, these results suggest that physalin D inhibits RANKL-induced osteoclastogenesis and bone loss via suppressing the PLCgamma2-CaMK-CREB pathway.	physalin D	43-53	cAMP responsive element binding protein 1	Mus musculus	145-149
31841868-9	2020	In brain cortex, DBP-treated mothers showed decrease in protein expression of Nr4a3, Egr1, Arc, BDNF and phosphorylation of AKT and CREB, were also decreased in cortex of DBP-treated mothers.	Dibutyl Phthalate	17-20	cAMP responsive element binding protein 1	Mus musculus	132-136
31841868-9	2020	In brain cortex, DBP-treated mothers showed decrease in protein expression of Nr4a3, Egr1, Arc, BDNF and phosphorylation of AKT and CREB, were also decreased in cortex of DBP-treated mothers.	Dibutyl Phthalate	171-174	cAMP responsive element binding protein 1	Mus musculus	132-136
31962134-3	2020	Moreover, signaling networks such as the cAMP/PKA/CREB pathway, which are critical for memory consolidation, are dampened in healthy aged subjects.	Cyclic AMP	41-45	cAMP responsive element binding protein 1	Mus musculus	50-54
31691145-5	2020	Supplementation of verapamil was found to attenuate oxidative stress by preventing mitochondrial injury, and augment the expression of genes involved in the cholinergic function (mACR1), synaptic plasticity (GAP43, SYP) and Ca2+-dependent memory-related genes (CREB1, CREBBP, BDNF).	Verapamil	19-28	cAMP responsive element binding protein 1	Mus musculus	261-266
31962134-4	2020	Phosphodiesterase (PDE) enzymes that break down cAMP are also affected by aging, and increased break down of cAMP by PDEs may contribute to reduced activity of the cAMP/PKA/CREB signaling network in the brain of aged individuals.	Cyclic AMP	48-52	cAMP responsive element binding protein 1	Mus musculus	173-177
31962134-4	2020	Phosphodiesterase (PDE) enzymes that break down cAMP are also affected by aging, and increased break down of cAMP by PDEs may contribute to reduced activity of the cAMP/PKA/CREB signaling network in the brain of aged individuals.	Cyclic AMP	109-113	cAMP responsive element binding protein 1	Mus musculus	173-177
31962134-4	2020	Phosphodiesterase (PDE) enzymes that break down cAMP are also affected by aging, and increased break down of cAMP by PDEs may contribute to reduced activity of the cAMP/PKA/CREB signaling network in the brain of aged individuals.	Cyclic AMP	109-113	cAMP responsive element binding protein 1	Mus musculus	173-177
32014112-2	2020	Here we show that cAMP-PKA-CREB signaling (a pattern recognition receptor [PRR]-independent mechanism) regulates conventional type-2 Dendritic Cells (cDC2s) in mice and reprograms their Th17-inducing properties via repression of IRF4 and KLF4, transcription factors essential for cDC2-mediated Th2 induction.	Cyclic AMP	18-22	cAMP responsive element binding protein 1	Mus musculus	27-31
32148659-8	2020	Moreover, changes in the levels of CREB and MeCP2, which were considered to interact with BDNF promoter IV, were also rescued by resveratrol.	Resveratrol	129-140	cAMP responsive element binding protein 1	Mus musculus	35-39
31809762-0	2020	GW9508 ameliorates cognitive impairment via the cAMP-CREB and JNK pathways in APPswe/PS1dE9 mouse model of Alzheimer"s disease.	GW9508	0-6	cAMP responsive element binding protein 1	Mus musculus	53-57
31809762-0	2020	GW9508 ameliorates cognitive impairment via the cAMP-CREB and JNK pathways in APPswe/PS1dE9 mouse model of Alzheimer"s disease.	Cyclic AMP	48-52	cAMP responsive element binding protein 1	Mus musculus	53-57
31809762-6	2020	The results revealed that treatment with GW9508 could significantly ameliorate cognitive deficits of APP/PS1 mice, upregulate the expression levels of cAMP, p-CREB and neurotrophic factors in vivo, while GW9508 also ameliorate Abeta1-42-induced neuron damage and downregulate the expression levels of pathological protein such as p-JNK, JNK and apoptosis-related proteins such as IL-6, IL-1beta, TNF-alpha and caspase-3 in vitro.	GW9508	41-47	cAMP responsive element binding protein 1	Mus musculus	159-163
32066705-0	2020	Dl-3-n-butylphthalide attenuates mouse behavioral deficits to chronic social defeat stress by regulating energy metabolism via AKT/CREB signaling pathway.	3-n-butylphthalide	0-21	cAMP responsive element binding protein 1	Mus musculus	131-135
32066705-7	2020	Real-time quantitative polymerase chain reaction and western blotting were used to examine key genes and proteins involved in energy metabolism and the AKT/cAMP response element-binding protein (CREB) signaling pathway.	Cyclic AMP	156-160	cAMP responsive element binding protein 1	Mus musculus	195-199
32066705-9	2020	NBP affected gene expression of key enzymes of the TCA cycle, as well as protein expression of p-AKT and p-CREB.	3-n-butylphthalide	0-3	cAMP responsive element binding protein 1	Mus musculus	107-111
32066705-10	2020	Our findings provide the first evidence showing that NBP can attenuate stress-induced behavioral deficits by modulating energy metabolism by regulating activation of the AKT/CREB signaling pathway.	3-n-butylphthalide	53-56	cAMP responsive element binding protein 1	Mus musculus	174-178
31676444-16	2020	H-89, a PKA inhibitor, suppressed CREB activation, lipid accumulation and NOX activity in RAW264.7 cells.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	0-4	cAMP responsive element binding protein 1	Mus musculus	34-38
31683445-0	2020	Knockdown of TNFAIP1 prevents di-(2-ethylhexyl) phthalate-induced neurotoxicity by activating CREB pathway.	Diethylhexyl Phthalate	30-57	cAMP responsive element binding protein 1	Mus musculus	94-98
31743748-0	2020	Citalopram prevents sleep-deprivation-induced reduction in CaMKII-CREB-BDNF signaling in mouse prefrontal cortex.	Citalopram	0-10	cAMP responsive element binding protein 1	Mus musculus	66-70
31683445-6	2020	We found that exposure to DEHP induced apoptosis and downregulated the expression of brain-derived neurotrophic factor (BDNF), synaptic proteins PSD 95 and synapsin-1 while upregulated the expression of TNFAIP1 and decreased the levels of phosphorylated Akt, CaMK IV, catalytic subunits of PKA and CREB in CREB signaling pathway.	Diethylhexyl Phthalate	26-30	cAMP responsive element binding protein 1	Mus musculus	298-302
31683445-6	2020	We found that exposure to DEHP induced apoptosis and downregulated the expression of brain-derived neurotrophic factor (BDNF), synaptic proteins PSD 95 and synapsin-1 while upregulated the expression of TNFAIP1 and decreased the levels of phosphorylated Akt, CaMK IV, catalytic subunits of PKA and CREB in CREB signaling pathway.	Diethylhexyl Phthalate	26-30	cAMP responsive element binding protein 1	Mus musculus	306-310
31683445-8	2020	Our data indicate that downregulation of TNFAIP1 prevents DEHP-induced neurotoxicity via activating CREB pathway.	Diethylhexyl Phthalate	58-62	cAMP responsive element binding protein 1	Mus musculus	100-104
31232473-3	2020	In this study, our results illustrated that DJ-1 can directly interact with Ca2+ /calmodulin-dependent protein kinase kinase beta (CaMKKbeta) and modifies the cAMP-responsive element binding protein 1 (CREB1) activity, thus regulates tyrosine hydroxylase (TH) expression.	Tyrosine	234-242	cAMP responsive element binding protein 1	Mus musculus	159-200
31232473-3	2020	In this study, our results illustrated that DJ-1 can directly interact with Ca2+ /calmodulin-dependent protein kinase kinase beta (CaMKKbeta) and modifies the cAMP-responsive element binding protein 1 (CREB1) activity, thus regulates tyrosine hydroxylase (TH) expression.	Tyrosine	234-242	cAMP responsive element binding protein 1	Mus musculus	202-207
29847220-0	2020	Apigenin reverses behavioural impairments and cognitive decline in kindled mice via CREB-BDNF upregulation in the hippocampus.	Apigenin	0-8	cAMP responsive element binding protein 1	Mus musculus	84-88
29847220-8	2020	Furthermore, increase in the hippocampus protein expression of brain-derived neurotrophic factor (BDNF), cAMP response element binding protein (CREB), and phosphorylated CREB, with increased serotonin level were also observed in the treated animals.	Serotonin	191-200	cAMP responsive element binding protein 1	Mus musculus	144-148
29847220-8	2020	Furthermore, increase in the hippocampus protein expression of brain-derived neurotrophic factor (BDNF), cAMP response element binding protein (CREB), and phosphorylated CREB, with increased serotonin level were also observed in the treated animals.	Serotonin	191-200	cAMP responsive element binding protein 1	Mus musculus	170-174
32038255-5	2019	Thioperamide promotes the phosphorylation of cAMP-response element binding (CREB), and thereby upregulates the expression and release of brain-derived neurotrophic factor (BDNF).	thioperamide	0-12	cAMP responsive element binding protein 1	Mus musculus	45-74
32038255-5	2019	Thioperamide promotes the phosphorylation of cAMP-response element binding (CREB), and thereby upregulates the expression and release of brain-derived neurotrophic factor (BDNF).	thioperamide	0-12	cAMP responsive element binding protein 1	Mus musculus	76-80
32038255-6	2019	However, H89, an inhibitor of protein kinase A (PKA)/CREB, reverses the effects of thioperamide on either BDNF expression and release or cell proliferation in NE-4C stem cells.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	9-12	cAMP responsive element binding protein 1	Mus musculus	53-57
32038255-6	2019	However, H89, an inhibitor of protein kinase A (PKA)/CREB, reverses the effects of thioperamide on either BDNF expression and release or cell proliferation in NE-4C stem cells.	thioperamide	83-95	cAMP responsive element binding protein 1	Mus musculus	53-57
32038255-9	2019	Taken together, these findings showed that thioperamide protects primary neurons against OGD-induced injury and promotes the proliferation of neural stem cells in DG and SVZ regions through CREB/BDNF pathways, thereby improving cognitive deficit.	thioperamide	43-55	cAMP responsive element binding protein 1	Mus musculus	190-194
31722235-6	2020	Furthermore, SIRT1 can also regulate the balance between glucose and lipid metabolism through CREB deacetylation.	Glucose	57-64	cAMP responsive element binding protein 1	Mus musculus	94-98
31722235-8	2020	Our results demonstrated that the BCP mice developed significant mechanical allodynia and spontaneous flinching, which were accompanied by the upregulation of phospho-Ser133 CREB (p-CREB) and CRTC1 expression in the spinal cord.	seryl-seryl-seryl-arginine	167-170	cAMP responsive element binding protein 1	Mus musculus	174-178
31924228-0	2020	Isotalatizidine, a C19-diterpenoid alkaloid, attenuates chronic neuropathic pain through stimulating ERK/CREB signaling pathway-mediated microglial dynorphin A expression.	isotalatizidine	0-15	cAMP responsive element binding protein 1	Mus musculus	105-109
31722235-8	2020	Our results demonstrated that the BCP mice developed significant mechanical allodynia and spontaneous flinching, which were accompanied by the upregulation of phospho-Ser133 CREB (p-CREB) and CRTC1 expression in the spinal cord.	seryl-seryl-seryl-arginine	167-170	cAMP responsive element binding protein 1	Mus musculus	182-186
31905173-0	2020	Activation of alpha7 nAChR by PNU-282987 improves synaptic and cognitive functions through restoring the expression of synaptic-associated proteins and the CaM-CaMKII-CREB signaling pathway.	N-neopentyl-N-nitrosourea	30-33	cAMP responsive element binding protein 1	Mus musculus	167-171
31924228-0	2020	Isotalatizidine, a C19-diterpenoid alkaloid, attenuates chronic neuropathic pain through stimulating ERK/CREB signaling pathway-mediated microglial dynorphin A expression.	ent-7beta,11alpha,14-trihydroxy-18-aldehyde-11beta-20-epoxy-kaur-16-en15-one	19-43	cAMP responsive element binding protein 1	Mus musculus	105-109
31924228-6	2020	At the molecular level, isotalatizidine selectively increased the phosphorylation of p38 and ERK1/2, in addition to activating the transcription factor CREB and increasing dynorphin A production in cultured primary microglia.	isotalatizidine	24-39	cAMP responsive element binding protein 1	Mus musculus	152-156
31924228-7	2020	However, the downstream effects of isotalatizidine were abrogated by the selective ERK1/2 inhibitor U0126-EtOH or CREB inhibitor of KG-501, but not by the p38 inhibitor SB203580.	isotalatizidine	35-50	cAMP responsive element binding protein 1	Mus musculus	114-118
31924228-7	2020	However, the downstream effects of isotalatizidine were abrogated by the selective ERK1/2 inhibitor U0126-EtOH or CREB inhibitor of KG-501, but not by the p38 inhibitor SB203580.	naphthol AS-E phosphate	132-138	cAMP responsive element binding protein 1	Mus musculus	114-118
31924228-9	2020	CONCLUSION: Taken together, isotalatizidine specifically activates the ERK1/2 pathway and subsequently CREB, which triggers dynorphin A release in the microglia, eventually leading to its anti-nociceptive action.	isotalatizidine	28-43	cAMP responsive element binding protein 1	Mus musculus	103-107
31976031-6	2020	Importantly, BBR blunted glucagon-induced glucose production and gluconeogenic gene expression in hepatocytes, presumably through reducing cAMP, which resulted in the phosphorylation of CREB.	Cyclic AMP	139-143	cAMP responsive element binding protein 1	Mus musculus	186-190
31848242-6	2020	This appeared to have taken effect through increased cyclic adenosine monophosphate (cAMP) response element binding (CREB)/CREB binding protein-mediated expression of the purinergic receptor P2X5 in the DRGs.	Cyclic AMP	53-83	cAMP responsive element binding protein 1	Mus musculus	117-121
31848242-6	2020	This appeared to have taken effect through increased cyclic adenosine monophosphate (cAMP) response element binding (CREB)/CREB binding protein-mediated expression of the purinergic receptor P2X5 in the DRGs.	Cyclic AMP	85-89	cAMP responsive element binding protein 1	Mus musculus	117-121
31976031-8	2020	BBR reduces the intracellular cAMP level by activating PDE, thus blocking activation of downstream CREB and eventually downregulating gluconeogenic genes to restrain hepatic glucose production.	Cyclic AMP	30-34	cAMP responsive element binding protein 1	Mus musculus	99-103
33350988-6	2020	Additionally, p-CREB and p-ERK levels in the spinal cord and the adrenal gland increased after formalin injection.	Formaldehyde	95-103	cAMP responsive element binding protein 1	Mus musculus	16-20
31656084-9	2020	Particularly, activation of the cAMP-responsive element-binding protein-1 (CREB1) pathway contributed to the ability of AA2G to maintain naive pluripotency of mESCs and functionality of hMSCs.	ascorbic acid 2-O-glucoside	120-124	cAMP responsive element binding protein 1	Mus musculus	32-73
31656084-0	2020	Ascorbic acid 2-glucoside stably promotes the primitiveness of embryonic and mesenchymal stem cells through TET- and CREB1-dependent mechanisms.	ascorbic acid 2-O-glucoside	0-25	cAMP responsive element binding protein 1	Mus musculus	117-122
33350988-7	2020	Pretreatment with beta-amyloid attenuated formalin-induced overexpression of p-CREB and p-ERK in the spinal cord and the adrenal gland.	Formaldehyde	42-50	cAMP responsive element binding protein 1	Mus musculus	79-83
33350988-9	2020	Furthermore, the reduction of nociception by beta-amyloid in the formalin pain model appears to be mediated, at least in part, by the suppression of p-CREB and p-ERK level in the spinal cord and the adrenal gland.	Formaldehyde	65-73	cAMP responsive element binding protein 1	Mus musculus	151-155
31656084-9	2020	Particularly, activation of the cAMP-responsive element-binding protein-1 (CREB1) pathway contributed to the ability of AA2G to maintain naive pluripotency of mESCs and functionality of hMSCs.	ascorbic acid 2-O-glucoside	120-124	cAMP responsive element binding protein 1	Mus musculus	75-80
31656084-11	2020	Furthermore, we demonstrate the significance of the CREB1 pathway in the mechanism of action of AA2G.	ascorbic acid 2-O-glucoside	96-100	cAMP responsive element binding protein 1	Mus musculus	52-57
31521867-0	2020	Metformin ameliorates stress-induced depression-like behaviors via enhancing the expression of BDNF by activating AMPK/CREB-mediated histone acetylation.	Metformin	0-9	cAMP responsive element binding protein 1	Mus musculus	119-123
32015688-0	2020	Empagliflozin Attenuates Hyperuricemia by Upregulation of ABCG2 via AMPK/AKT/CREB Signaling Pathway in Type 2 Diabetic Mice.	empagliflozin	0-13	cAMP responsive element binding protein 1	Mus musculus	77-81
32015688-11	2020	Taken together, our study demonstrated that empagliflozin treatment played an essential role in attenuating HUA by upregulation of ABCG2 via AMPK/AKT/CREB signaling pathway.	empagliflozin	44-57	cAMP responsive element binding protein 1	Mus musculus	150-154
31521867-7	2020	At a molecular level, metformin significantly upregulated the expression of the brain-derived neurotrophic factor (BDNF) by increasing the histone acetylation along with the BDNF promoter, which was attributed to the activation of AMP-activated protein kinase (AMPK) and cAMP-response element binding protein (CREB).	Metformin	22-31	cAMP responsive element binding protein 1	Mus musculus	271-308
31521867-7	2020	At a molecular level, metformin significantly upregulated the expression of the brain-derived neurotrophic factor (BDNF) by increasing the histone acetylation along with the BDNF promoter, which was attributed to the activation of AMP-activated protein kinase (AMPK) and cAMP-response element binding protein (CREB).	Metformin	22-31	cAMP responsive element binding protein 1	Mus musculus	310-314
31704270-8	2020	Whereas acute cocaine-treated mice showed transient increases in p-ERK1/2/ERK1/2 and p-p65/p65 NFkappaB ratios after cocaine injection, repeated cocaine-treated mice showed transient increases in p-ERK1/2/ERK1/2, p-p38/p38 MAPK, p-NFkappaB p65/NF-kappaB p65 and p-CREB/CREB ratios.	Cocaine	14-21	cAMP responsive element binding protein 1	Mus musculus	264-268
32597808-1	2020	BACKGROUND: Coordinated calcium influx upon neuronal depolarization activates pathways that phosphorylate CaMKII, ERKs, and the transcription factor CREB and, therefore, expression of pro-survival and neuroprotective genes.	Calcium	24-31	cAMP responsive element binding protein 1	Mus musculus	149-153
31535661-8	2020	Pretreatment with GLYX-13 ameliorated isoflurane exposure-induced cognitive impairment and restored NR2B, CaMKII and CREB mRNA and phosphorylated protein levels.	GLYX-13 peptide	18-25	cAMP responsive element binding protein 1	Mus musculus	117-121
31535661-10	2020	Taken together, our findings suggest that GLYX-13 pretreatment alleviates isoflurane-induced cognitive dysfunction by protecting against perturbation of the NR2B/CaMKII/CREB signaling pathway in the hippocampus.	GLYX-13 peptide	42-49	cAMP responsive element binding protein 1	Mus musculus	169-173
31535661-10	2020	Taken together, our findings suggest that GLYX-13 pretreatment alleviates isoflurane-induced cognitive dysfunction by protecting against perturbation of the NR2B/CaMKII/CREB signaling pathway in the hippocampus.	Isoflurane	74-84	cAMP responsive element binding protein 1	Mus musculus	169-173
31918924-13	2020	CONCLUSIONS: Taken together, these results illustrate a new model in which Purbeta functions to regulate the glucagon/ADCY6/cAMP/PKA/CREB signaling pathway to help maintain glucose homeostasis.	Cyclic AMP	124-128	cAMP responsive element binding protein 1	Mus musculus	133-137
31918924-13	2020	CONCLUSIONS: Taken together, these results illustrate a new model in which Purbeta functions to regulate the glucagon/ADCY6/cAMP/PKA/CREB signaling pathway to help maintain glucose homeostasis.	Glucose	173-180	cAMP responsive element binding protein 1	Mus musculus	133-137
31704270-9	2020	Baseline p-p38/p38 MAPK and p-CREB/CREB ratios were downregulated in repeated cocaine-treated mice.	Cocaine	78-85	cAMP responsive element binding protein 1	Mus musculus	30-34
31704270-9	2020	Baseline p-p38/p38 MAPK and p-CREB/CREB ratios were downregulated in repeated cocaine-treated mice.	Cocaine	78-85	cAMP responsive element binding protein 1	Mus musculus	35-39
31704270-8	2020	Whereas acute cocaine-treated mice showed transient increases in p-ERK1/2/ERK1/2 and p-p65/p65 NFkappaB ratios after cocaine injection, repeated cocaine-treated mice showed transient increases in p-ERK1/2/ERK1/2, p-p38/p38 MAPK, p-NFkappaB p65/NF-kappaB p65 and p-CREB/CREB ratios.	Cocaine	14-21	cAMP responsive element binding protein 1	Mus musculus	269-273
31818003-7	2019	PGE2 stimulated M2 polarization via the EP4-cAMP-CREB in normal mice, while failed to promote M2 polarization in the PMs of CIA mice.	Dinoprostone	0-4	cAMP responsive element binding protein 1	Mus musculus	49-53
31889894-0	2019	Sulforaphene induces apoptosis and inhibits the invasion of esophageal cancer cells through MSK2/CREB/Bcl-2 and cadherin pathway in vivo and in vitro.	sulphoraphene	0-12	cAMP responsive element binding protein 1	Mus musculus	97-101
31889894-8	2019	We found that sulforaphene could repress the phosphorylation of CREB through MSK2, leading to suppression of Bcl-2 and further promoted cell apoptosis.	sulphoraphene	14-26	cAMP responsive element binding protein 1	Mus musculus	64-68
31889894-11	2019	Conclusions: Our data demonstrated that sulforaphene induced cell apoptosis and inhibits the invasion of esophageal cancer through a mechanism involving the inhibition of the MSK2-CREB-Bcl2 and cadherin pathway.	sulphoraphene	40-52	cAMP responsive element binding protein 1	Mus musculus	180-184
31651704-0	2019	Asiaticoside but not its aglycone exhibits neuritogenicity through TrkA receptor signaling: a bridge between ERK1/2-CREB and Akt-GSK3beta/RhoA.	asiaticoside	0-12	cAMP responsive element binding protein 1	Mus musculus	116-120
31818003-7	2019	PGE2 stimulated M2 polarization via the EP4-cAMP-CREB in normal mice, while failed to promote M2 polarization in the PMs of CIA mice.	Cyclic AMP	44-48	cAMP responsive element binding protein 1	Mus musculus	49-53
31818003-8	2019	Further, we found the EP4 over-desensitization stimulated by PGE2 induced abnormal PGE2-cAMP-CREB signaling as well as the imbalance of macrophage polarization.	Dinoprostone	61-65	cAMP responsive element binding protein 1	Mus musculus	93-97
31818003-8	2019	Further, we found the EP4 over-desensitization stimulated by PGE2 induced abnormal PGE2-cAMP-CREB signaling as well as the imbalance of macrophage polarization.	pge2-camp	83-92	cAMP responsive element binding protein 1	Mus musculus	93-97
31866806-6	2019	Induction of CREB phosphorylation, a hallmark of the light/glutamate response of the SCN, also is absent in SCN-containing ex vivo slices from PACAP-deficient mouse hypothalamus.	Glutamic Acid	59-68	cAMP responsive element binding protein 1	Mus musculus	13-17
31445131-0	2019	Total glucosides of paeony (TGP) extracted from Radix Paeoniae Alba exerts neuroprotective effects in MPTP-induced experimental parkinsonism by regulating the cAMP/PKA/CREB signaling pathway.	Glucosides	6-16	cAMP responsive element binding protein 1	Mus musculus	168-172
31806049-1	2019	CREB (cyclic AMP response element binding protein) binding protein (CBP, CREBBP) is a ubiquitously expressed transcription coactivator with intrinsic histone acetyltransferase (KAT) activity.	Cyclic AMP	6-16	cAMP responsive element binding protein 1	Mus musculus	0-4
31445131-0	2019	Total glucosides of paeony (TGP) extracted from Radix Paeoniae Alba exerts neuroprotective effects in MPTP-induced experimental parkinsonism by regulating the cAMP/PKA/CREB signaling pathway.	Cyclic AMP	159-163	cAMP responsive element binding protein 1	Mus musculus	168-172
31791357-11	2019	In addition, PAP elevated intracellular cAMP levels and CREB phosphorylation.	Papaverine	13-16	cAMP responsive element binding protein 1	Mus musculus	56-60
31638299-4	2019	In the present study, the EGF-activation of EGF receptor (EGFR) induced cyclic adenosine 3",5"-monophosphate (cAMP) response element-binding protein (CREB) phosphorylation in cumulus cells, and the interruption of CREB functional complex formation by naphthol AS-E phosphate (KG-501) completely blocked the EGF-stimulated expansion-related gene expression.	Adenosine	79-88	cAMP responsive element binding protein 1	Mus musculus	150-154
31539617-7	2019	Fisetin also reversed Pb-induced synaptic dysfunction by increasing the levels of synaptosomal associated protein-25 (SNAP-25), postsynaptic density-95 (PSD-95), cyclic-AMP-response element-binding protein (CREB) phosphorylation and calcium/calmodulin kinase II (CaMKII) phosphorylation.	fisetin	0-7	cAMP responsive element binding protein 1	Mus musculus	162-205
31539617-7	2019	Fisetin also reversed Pb-induced synaptic dysfunction by increasing the levels of synaptosomal associated protein-25 (SNAP-25), postsynaptic density-95 (PSD-95), cyclic-AMP-response element-binding protein (CREB) phosphorylation and calcium/calmodulin kinase II (CaMKII) phosphorylation.	fisetin	0-7	cAMP responsive element binding protein 1	Mus musculus	207-211
31678866-0	2019	Activation of RAW264.7 macrophages by active fraction of Albizia julibrissin saponin via Ca2+-ERK1/2-CREB-lncRNA pathways.	Saponins	77-84	cAMP responsive element binding protein 1	Mus musculus	101-105
31678866-0	2019	Activation of RAW264.7 macrophages by active fraction of Albizia julibrissin saponin via Ca2+-ERK1/2-CREB-lncRNA pathways.	Calcium	89-93	cAMP responsive element binding protein 1	Mus musculus	101-105
31678866-10	2019	Moreover, Ca2+ chelator BAPTA-AM, ERK1/2 inhibitor PD98059 and CREB inhibitor KG-501 significantly inhibited the up-regulation of TNF-alpha, CCL2, CXCL2, CCL22, and A_30_P01018532 in RAW264.7 cells induced by AJSAF.	naphthol AS-E phosphate	78-84	cAMP responsive element binding protein 1	Mus musculus	63-67
31647947-6	2019	Progesterone increased the levels of CREB and PPARgamma in the cerebral cortex of APP/PS1 mice.	Progesterone	0-12	cAMP responsive element binding protein 1	Mus musculus	37-41
31647947-8	2019	Meanwhile, progesterone increased the expression of GLUT3, GLUT4, CREB and PPARgamma, and AG205 blocked this effect.	Progesterone	11-23	cAMP responsive element binding protein 1	Mus musculus	66-70
31647947-9	2019	SIGNIFICANCE: These results confirm that progesterone significantly improves the glucose metabolism of neurons.One of the mechanisms of this effect is that progesterone upregulates protein expression of GLUT3 and GLUT4 through pathways PGRMC1/CREB/GLUT3 and PGRMC1/PPARgamma/GLUT4.	Progesterone	41-53	cAMP responsive element binding protein 1	Mus musculus	243-247
31647947-9	2019	SIGNIFICANCE: These results confirm that progesterone significantly improves the glucose metabolism of neurons.One of the mechanisms of this effect is that progesterone upregulates protein expression of GLUT3 and GLUT4 through pathways PGRMC1/CREB/GLUT3 and PGRMC1/PPARgamma/GLUT4.	Glucose	81-88	cAMP responsive element binding protein 1	Mus musculus	243-247
31647947-9	2019	SIGNIFICANCE: These results confirm that progesterone significantly improves the glucose metabolism of neurons.One of the mechanisms of this effect is that progesterone upregulates protein expression of GLUT3 and GLUT4 through pathways PGRMC1/CREB/GLUT3 and PGRMC1/PPARgamma/GLUT4.	Progesterone	156-168	cAMP responsive element binding protein 1	Mus musculus	243-247
31638299-5	2019	EGF-stimulated phosphorylation of CREB was completely inhibited by MAPK3/1 inhibitor U0126, suggesting that EGF-activated MAPK3/1 results in the activation of CREB for cumulus expansion.	U 0126	85-90	cAMP responsive element binding protein 1	Mus musculus	159-163
31638299-4	2019	In the present study, the EGF-activation of EGF receptor (EGFR) induced cyclic adenosine 3",5"-monophosphate (cAMP) response element-binding protein (CREB) phosphorylation in cumulus cells, and the interruption of CREB functional complex formation by naphthol AS-E phosphate (KG-501) completely blocked the EGF-stimulated expansion-related gene expression.	Cyclic AMP	110-114	cAMP responsive element binding protein 1	Mus musculus	150-154
31638299-4	2019	In the present study, the EGF-activation of EGF receptor (EGFR) induced cyclic adenosine 3",5"-monophosphate (cAMP) response element-binding protein (CREB) phosphorylation in cumulus cells, and the interruption of CREB functional complex formation by naphthol AS-E phosphate (KG-501) completely blocked the EGF-stimulated expansion-related gene expression.	Cyclic AMP	110-114	cAMP responsive element binding protein 1	Mus musculus	214-218
31638299-4	2019	In the present study, the EGF-activation of EGF receptor (EGFR) induced cyclic adenosine 3",5"-monophosphate (cAMP) response element-binding protein (CREB) phosphorylation in cumulus cells, and the interruption of CREB functional complex formation by naphthol AS-E phosphate (KG-501) completely blocked the EGF-stimulated expansion-related gene expression.	naphthol AS-E phosphate	251-274	cAMP responsive element binding protein 1	Mus musculus	150-154
31425745-0	2019	Danshensu attenuates scopolamine and amyloid-beta-induced cognitive impairments through the activation of PKA-CREB signaling in mice.	3,4-dihydroxyphenyllactic acid	0-9	cAMP responsive element binding protein 1	Mus musculus	110-114
31425745-8	2019	Additionally, danshensu treatment increased the dopamine level and the phosphorylation levels of protein kinase A (PKA) and cAMP response element binding protein (CREB), in the cortex of the brain.	3,4-dihydroxyphenyllactic acid	14-23	cAMP responsive element binding protein 1	Mus musculus	124-161
31425745-8	2019	Additionally, danshensu treatment increased the dopamine level and the phosphorylation levels of protein kinase A (PKA) and cAMP response element binding protein (CREB), in the cortex of the brain.	3,4-dihydroxyphenyllactic acid	14-23	cAMP responsive element binding protein 1	Mus musculus	163-167
31425745-11	2019	The results revealed that danshensu treatment significantly improved scopolamine and Abeta-induced cognitive impairments in mice by facilitation of dopamine signaling cascade such as PKA and CREB due to MAO-A inhibition.	3,4-dihydroxyphenyllactic acid	26-35	cAMP responsive element binding protein 1	Mus musculus	191-195
31638299-4	2019	In the present study, the EGF-activation of EGF receptor (EGFR) induced cyclic adenosine 3",5"-monophosphate (cAMP) response element-binding protein (CREB) phosphorylation in cumulus cells, and the interruption of CREB functional complex formation by naphthol AS-E phosphate (KG-501) completely blocked the EGF-stimulated expansion-related gene expression.	naphthol AS-E phosphate	276-282	cAMP responsive element binding protein 1	Mus musculus	150-154
31425745-11	2019	The results revealed that danshensu treatment significantly improved scopolamine and Abeta-induced cognitive impairments in mice by facilitation of dopamine signaling cascade such as PKA and CREB due to MAO-A inhibition.	Dopamine	148-156	cAMP responsive element binding protein 1	Mus musculus	191-195
31638299-5	2019	EGF-stimulated phosphorylation of CREB was completely inhibited by MAPK3/1 inhibitor U0126, suggesting that EGF-activated MAPK3/1 results in the activation of CREB for cumulus expansion.	U 0126	85-90	cAMP responsive element binding protein 1	Mus musculus	34-38
31819374-12	2019	In addition, FTS could inhibit the levels of hippocampal p-ERK and p-CREB activated by Abeta, which is the underlying molecular mechanism.	UNII-042A8N37WH	87-92	cAMP responsive element binding protein 1	Mus musculus	69-73
31691882-6	2019	Notably, a STEP inhibitor TC-2153 treatment alleviated sepsis-induced memory impairment by increasing phosphorylation of GluN2B and ERK1/2, CREB/BDNF, and PSD95.	8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine	26-33	cAMP responsive element binding protein 1	Mus musculus	140-144
31209627-9	2019	Furthermore, lidocaine upregulated SOCS3 expression dependent of pCREB, and CREB silencing greatly discounted this effect.	Lidocaine	13-22	cAMP responsive element binding protein 1	Mus musculus	66-70
31707258-5	2019	We also found that ultrasound significantly increased the expression of the important proteins phospho-CaMKII, phospho-CREB, and c-Fos in a neuronal cell line, but Piezo1 knockdown significantly reduced this effect.	phosphorylleucylphenylalanine	111-118	cAMP responsive element binding protein 1	Mus musculus	119-123
31542427-8	2019	Moreover, DS treatment significantly upregulated BDNF, pTrkB/TrkB, pAkt/Akt, pPI3K/PI3K, pCREB/CREB, pERK1/2/ERK1/2 and pmTOR/mTOR protein expression in the hippocampus.	dammarane	10-12	cAMP responsive element binding protein 1	Mus musculus	90-94
31542427-9	2019	In conclusion, our results showed that DS exerts antidepressant-like effects in mice with CSDS-induced depression, that the effects may be mediated by the normalization of monoamine neurotransmitter levels, the prevention of HPA axis dysfunction and the impairment of hippocampal neurogenesis, and that this occurs partly through the ability of DS to enhance BDNF expression by increasing the TrkB/CREB/ERK pathway and the PI3K/AKT/mTOR pathway.	dammarane	39-41	cAMP responsive element binding protein 1	Mus musculus	398-402
31176710-0	2019	Therapeutic Potential of Rottlerin for Skin Hyperpigmentary Disorders by Inhibiting the Transcriptional Activity of CREB-Regulated Transcription Coactivators.	rottlerin	25-34	cAMP responsive element binding protein 1	Mus musculus	116-120
31176710-3	2019	Because cAMP-responsive element binding protein (CREB) and CREB-regulated transcription coactivators (CRTC) play a major role in conveying cAMP signals that induce transcription of microphthalmia-associated transcription factor and melanin production, we screened for a CREB or CRTC inhibitor and identified rottlerin (Rot) as a potent inhibitor of its transcriptional activity.	Cyclic AMP	8-12	cAMP responsive element binding protein 1	Mus musculus	49-53
31176710-3	2019	Because cAMP-responsive element binding protein (CREB) and CREB-regulated transcription coactivators (CRTC) play a major role in conveying cAMP signals that induce transcription of microphthalmia-associated transcription factor and melanin production, we screened for a CREB or CRTC inhibitor and identified rottlerin (Rot) as a potent inhibitor of its transcriptional activity.	Melanins	232-239	cAMP responsive element binding protein 1	Mus musculus	8-47
31176710-3	2019	Because cAMP-responsive element binding protein (CREB) and CREB-regulated transcription coactivators (CRTC) play a major role in conveying cAMP signals that induce transcription of microphthalmia-associated transcription factor and melanin production, we screened for a CREB or CRTC inhibitor and identified rottlerin (Rot) as a potent inhibitor of its transcriptional activity.	Melanins	232-239	cAMP responsive element binding protein 1	Mus musculus	49-53
31176710-3	2019	Because cAMP-responsive element binding protein (CREB) and CREB-regulated transcription coactivators (CRTC) play a major role in conveying cAMP signals that induce transcription of microphthalmia-associated transcription factor and melanin production, we screened for a CREB or CRTC inhibitor and identified rottlerin (Rot) as a potent inhibitor of its transcriptional activity.	Melanins	232-239	cAMP responsive element binding protein 1	Mus musculus	59-63
31176710-3	2019	Because cAMP-responsive element binding protein (CREB) and CREB-regulated transcription coactivators (CRTC) play a major role in conveying cAMP signals that induce transcription of microphthalmia-associated transcription factor and melanin production, we screened for a CREB or CRTC inhibitor and identified rottlerin (Rot) as a potent inhibitor of its transcriptional activity.	Melanins	232-239	cAMP responsive element binding protein 1	Mus musculus	59-63
31176710-3	2019	Because cAMP-responsive element binding protein (CREB) and CREB-regulated transcription coactivators (CRTC) play a major role in conveying cAMP signals that induce transcription of microphthalmia-associated transcription factor and melanin production, we screened for a CREB or CRTC inhibitor and identified rottlerin (Rot) as a potent inhibitor of its transcriptional activity.	rottlerin	308-317	cAMP responsive element binding protein 1	Mus musculus	8-47
31176710-3	2019	Because cAMP-responsive element binding protein (CREB) and CREB-regulated transcription coactivators (CRTC) play a major role in conveying cAMP signals that induce transcription of microphthalmia-associated transcription factor and melanin production, we screened for a CREB or CRTC inhibitor and identified rottlerin (Rot) as a potent inhibitor of its transcriptional activity.	rottlerin	308-317	cAMP responsive element binding protein 1	Mus musculus	49-53
31176710-3	2019	Because cAMP-responsive element binding protein (CREB) and CREB-regulated transcription coactivators (CRTC) play a major role in conveying cAMP signals that induce transcription of microphthalmia-associated transcription factor and melanin production, we screened for a CREB or CRTC inhibitor and identified rottlerin (Rot) as a potent inhibitor of its transcriptional activity.	rottlerin	308-317	cAMP responsive element binding protein 1	Mus musculus	59-63
31176710-3	2019	Because cAMP-responsive element binding protein (CREB) and CREB-regulated transcription coactivators (CRTC) play a major role in conveying cAMP signals that induce transcription of microphthalmia-associated transcription factor and melanin production, we screened for a CREB or CRTC inhibitor and identified rottlerin (Rot) as a potent inhibitor of its transcriptional activity.	rottlerin	308-317	cAMP responsive element binding protein 1	Mus musculus	59-63
31473580-6	2019	Furthermore, baicalin markedly suppressed p-p38 MAPK, p-CREB, FoxO1, PGC-1alpha, PEPCK and G6Pase expression in liver of obese mice and hepatocytes.	baicalin	13-21	cAMP responsive element binding protein 1	Mus musculus	56-60
31488603-7	2019	Furthermore, molecular studies showed that BPN14770 prevented Abeta-induced decreases in synaptophysin, postsynaptic density protein 95, phosphorylated cAMP-response element binding protein (CREB)/CREB, brain-derived neurotrophic factor, and nerve growth factor inducible protein levels in the hippocampus.	BPN14770	43-51	cAMP responsive element binding protein 1	Mus musculus	152-189
31488603-7	2019	Furthermore, molecular studies showed that BPN14770 prevented Abeta-induced decreases in synaptophysin, postsynaptic density protein 95, phosphorylated cAMP-response element binding protein (CREB)/CREB, brain-derived neurotrophic factor, and nerve growth factor inducible protein levels in the hippocampus.	BPN14770	43-51	cAMP responsive element binding protein 1	Mus musculus	191-195
31488603-7	2019	Furthermore, molecular studies showed that BPN14770 prevented Abeta-induced decreases in synaptophysin, postsynaptic density protein 95, phosphorylated cAMP-response element binding protein (CREB)/CREB, brain-derived neurotrophic factor, and nerve growth factor inducible protein levels in the hippocampus.	BPN14770	43-51	cAMP responsive element binding protein 1	Mus musculus	197-201
31278934-3	2019	FRP pretreatment suppressed scopolamine-induced cognitive impairment in passive-avoidance test and significantly upregulated levels of brain-derived neurotrophic factor (BDNF) and induced the phosphorylation of cAMP response element binding (CREB) protein and extracellular signal-regulated kinase (ERK) in the hippocampus of scopolamine-treated mice.	Scopolamine	28-39	cAMP responsive element binding protein 1	Mus musculus	211-240
31661767-7	2019	Treatment with ICA activated the cAMP/PKA/CREB signaling axis in a time-dependent manner.	Cyclic AMP	33-37	cAMP responsive element binding protein 1	Mus musculus	42-46
31717815-1	2019	Previously, we found that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson"s disease (PD) model mice (PD mice) showed facilitation of hippocampal memory extinction via reduced cyclic adenosine monophosphate (cAMP)/cAMP-dependent response element-binding protein (CREB) signaling, which may cause cognitive impairment in PD.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	26-70	cAMP responsive element binding protein 1	Mus musculus	284-288
31717815-1	2019	Previously, we found that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson"s disease (PD) model mice (PD mice) showed facilitation of hippocampal memory extinction via reduced cyclic adenosine monophosphate (cAMP)/cAMP-dependent response element-binding protein (CREB) signaling, which may cause cognitive impairment in PD.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	72-76	cAMP responsive element binding protein 1	Mus musculus	284-288
31717815-4	2019	Both 5-HT4R agonists restored facilitation of contextual fear extinction in PD mice by stimulating the cAMP/CREB pathway in the dentate gyrus of the hippocampus.	Cyclic AMP	103-107	cAMP responsive element binding protein 1	Mus musculus	108-112
31737188-0	2019	Pterostilbene attenuates amyloid-beta induced neurotoxicity with regulating PDE4A-CREB-BDNF pathway.	pterostilbene	0-13	cAMP responsive element binding protein 1	Mus musculus	82-86
31737188-8	2019	Overall, PTS protects neurons against Abeta-induced neurotoxicity and cognitive dysfunction through regulating the PDE4A-CREB-BDNF pathway.	pterostilbene	9-12	cAMP responsive element binding protein 1	Mus musculus	121-125
31255680-1	2019	The transcription factor CREB (cyclic AMP response element (CRE)-binding protein) is implicated in the pathophysiology and treatment of depression.	Cyclic AMP	31-41	cAMP responsive element binding protein 1	Mus musculus	25-29
31745529-6	2019	Detailed molecular analysis involving EMSA and chromatin immunoprecipitation assays demonstrated that cAMP response element binding protein (CREB) binds to these cAMP response element regions of the ZNF638 promoter, and functional studies revealed that CREB is necessary and sufficient to regulate the levels of ZNF638 transcripts.	Cyclic AMP	102-106	cAMP responsive element binding protein 1	Mus musculus	141-145
31745529-6	2019	Detailed molecular analysis involving EMSA and chromatin immunoprecipitation assays demonstrated that cAMP response element binding protein (CREB) binds to these cAMP response element regions of the ZNF638 promoter, and functional studies revealed that CREB is necessary and sufficient to regulate the levels of ZNF638 transcripts.	Cyclic AMP	102-106	cAMP responsive element binding protein 1	Mus musculus	253-257
31637050-8	2019	However, Rap1 protein was elevated and CREB phosphorylation was reduced in female nicotine place conditioning mice.	Nicotine	82-90	cAMP responsive element binding protein 1	Mus musculus	39-43
31278934-3	2019	FRP pretreatment suppressed scopolamine-induced cognitive impairment in passive-avoidance test and significantly upregulated levels of brain-derived neurotrophic factor (BDNF) and induced the phosphorylation of cAMP response element binding (CREB) protein and extracellular signal-regulated kinase (ERK) in the hippocampus of scopolamine-treated mice.	Scopolamine	326-337	cAMP responsive element binding protein 1	Mus musculus	211-240
30993592-6	2019	Results showed that TMAS treatment elevated the levels of BDNF, cAMP response element-binding protein (CREB), and protein kinase B (p-Akt) in the PD model mouse hippocampus, but not in the non-PD mouse hippocampus.	tmas	20-24	cAMP responsive element binding protein 1	Mus musculus	64-101
31555361-7	2019	Compared with the SCF single stimulation group, the production of IL-13 was significantly reduced in P815 cells stimulated with U0126 (ERK-MEK/pathway inhibitor) or H-89 (CREB inhibitor) combined with SCF stimulation group (P&lt;0.01).	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	165-169	cAMP responsive element binding protein 1	Mus musculus	171-175
30993592-6	2019	Results showed that TMAS treatment elevated the levels of BDNF, cAMP response element-binding protein (CREB), and protein kinase B (p-Akt) in the PD model mouse hippocampus, but not in the non-PD mouse hippocampus.	tmas	20-24	cAMP responsive element binding protein 1	Mus musculus	103-107
31351316-2	2019	Our previously published results from transgenic mice functionally lacking CREB in chosen neural populations have shown that BDNF upregulation evoked by chronic treatment with fluoxetine seems to be dependent on CREB residing exclusively in serotonergic neurons.	Fluoxetine	176-186	cAMP responsive element binding protein 1	Mus musculus	212-216
31351316-2	2019	Our previously published results from transgenic mice functionally lacking CREB in chosen neural populations have shown that BDNF upregulation evoked by chronic treatment with fluoxetine seems to be dependent on CREB residing exclusively in serotonergic neurons.	Fluoxetine	176-186	cAMP responsive element binding protein 1	Mus musculus	75-79
31429533-9	2019	CONCLUSION: The results of the study suggest that cuprizone treatment disrupts hippocampal neurogenesis in the dentate gyrus by reducing BDNF levels and decreasing the phosphorylation of CREB.	Cuprizone	50-59	cAMP responsive element binding protein 1	Mus musculus	187-191
31554738-7	2019	The effects of muscarinic receptor antagonism on promoting expansion of BFU-Es were mediated by cyclic AMP induction of the transcription factor CREB, whose targets up-regulated key regulators of BFU-E self-renewal.	Cyclic AMP	96-106	cAMP responsive element binding protein 1	Mus musculus	145-149
31680939-7	2019	In addition, CSA inhibited excessive expression of GluN2B-containing NMDARs and upregulated the downstream PKA/CREB/BDNF/TrkB signaling pathway.	3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	13-16	cAMP responsive element binding protein 1	Mus musculus	111-115
31588240-11	2019	In addition, combination treatment with ART and NVB significantly suppressed tumor growth in a nude mouse xenograft model, with downregulated CREB and PGC1alpha expression levels observed in tumor biopsies, in agreement with our in vitro and ex vivo data.	Artemisinins	40-43	cAMP responsive element binding protein 1	Mus musculus	142-146
31595165-6	2019	And further assays showed that the level of circ-HIPK3 in heart was upregulated by adrenaline via transcription factor CREB1 (cAMP responsive element-binding protein 1).	Epinephrine	83-93	cAMP responsive element binding protein 1	Mus musculus	119-124
31595165-6	2019	And further assays showed that the level of circ-HIPK3 in heart was upregulated by adrenaline via transcription factor CREB1 (cAMP responsive element-binding protein 1).	Epinephrine	83-93	cAMP responsive element binding protein 1	Mus musculus	126-167
31619982-9	2019	Synaptic plasticity-associated gene profiles were modified by HF-rTMS, especially neurotrophin signaling pathways and cyclic adenosine monophosphate response element binding protein (CREB) cofactors.	Cyclic AMP	118-148	cAMP responsive element binding protein 1	Mus musculus	183-187
31081159-11	2019	In addition, repeated morphine administration decreased the expression of postsynaptic density protein 95 (PSD95) and cAMP response element binding protein (CREB) phosphorylation in the prefrontal cortex (PFC) and hippocampus (HIP), and these effects were significantly reversed by naloxone in PFC.	Morphine	22-30	cAMP responsive element binding protein 1	Mus musculus	118-155
31318159-5	2019	QA inhibited the phosphorylation of PKC and its downstream molecules, GSK-3beta, ERK and CREB, enhanced the glutamate level and release of neuroinflammatory cytokines; these effects were attenuated by berberine.	Quinolinic Acid	0-2	cAMP responsive element binding protein 1	Mus musculus	89-93
31081159-11	2019	In addition, repeated morphine administration decreased the expression of postsynaptic density protein 95 (PSD95) and cAMP response element binding protein (CREB) phosphorylation in the prefrontal cortex (PFC) and hippocampus (HIP), and these effects were significantly reversed by naloxone in PFC.	Morphine	22-30	cAMP responsive element binding protein 1	Mus musculus	157-161
31350730-0	2019	Isoorientin improves scopolamine-induced cognitive impairments by restoring the cholinergic system, antioxidant defense, and p-CREB/BDNF signaling in the hippocampus and frontal cortex.	homoorientin	0-11	cAMP responsive element binding protein 1	Mus musculus	127-131
31447835-6	2019	We identified a set of two proximate and inter-dependent cAMP response element (CRE) sites that cooperatively regulate early IL-10 transcription in response to isoproterenol-stimulated CREB and that further synergize with a constitutive Sp1 site.	Cyclic AMP	57-61	cAMP responsive element binding protein 1	Mus musculus	185-189
31447835-6	2019	We identified a set of two proximate and inter-dependent cAMP response element (CRE) sites that cooperatively regulate early IL-10 transcription in response to isoproterenol-stimulated CREB and that further synergize with a constitutive Sp1 site.	Isoproterenol	160-173	cAMP responsive element binding protein 1	Mus musculus	185-189
31302262-2	2019	The present study, using a mouse model of chronic cerebral hypoperfusion, examined the white matter protective effects of levetiracetam, an anticonvulsant, via the signaling cascade from the activation of cAMP-responsive element binding protein (CREB) phosphorylation.	Levetiracetam	122-135	cAMP responsive element binding protein 1	Mus musculus	205-244
31302262-2	2019	The present study, using a mouse model of chronic cerebral hypoperfusion, examined the white matter protective effects of levetiracetam, an anticonvulsant, via the signaling cascade from the activation of cAMP-responsive element binding protein (CREB) phosphorylation.	Levetiracetam	122-135	cAMP responsive element binding protein 1	Mus musculus	246-250
31302262-9	2019	We found that 3-day treatment with levetiracetam maintained SV2A protein expression via interaction with astrocytes, which influenced the OPC lineage through activation of CREB to protect white matter from ischemia.	Levetiracetam	35-48	cAMP responsive element binding protein 1	Mus musculus	172-176
31350730-0	2019	Isoorientin improves scopolamine-induced cognitive impairments by restoring the cholinergic system, antioxidant defense, and p-CREB/BDNF signaling in the hippocampus and frontal cortex.	Scopolamine	21-32	cAMP responsive element binding protein 1	Mus musculus	127-131
31350730-8	2019	Moreover, Western blot results indicated that ISO reversed the decreases in expression of phosphorylated cAMP response element binding (CREB) and brain-derived neurotrophic factor (BDNF) in the hippocampus and frontal cortex of scopolamine-treated mice.	homoorientin	46-49	cAMP responsive element binding protein 1	Mus musculus	105-134
31350730-8	2019	Moreover, Western blot results indicated that ISO reversed the decreases in expression of phosphorylated cAMP response element binding (CREB) and brain-derived neurotrophic factor (BDNF) in the hippocampus and frontal cortex of scopolamine-treated mice.	homoorientin	46-49	cAMP responsive element binding protein 1	Mus musculus	136-140
31350730-8	2019	Moreover, Western blot results indicated that ISO reversed the decreases in expression of phosphorylated cAMP response element binding (CREB) and brain-derived neurotrophic factor (BDNF) in the hippocampus and frontal cortex of scopolamine-treated mice.	Scopolamine	228-239	cAMP responsive element binding protein 1	Mus musculus	105-134
31350730-8	2019	Moreover, Western blot results indicated that ISO reversed the decreases in expression of phosphorylated cAMP response element binding (CREB) and brain-derived neurotrophic factor (BDNF) in the hippocampus and frontal cortex of scopolamine-treated mice.	Scopolamine	228-239	cAMP responsive element binding protein 1	Mus musculus	136-140
31350730-9	2019	Thus, our results provide initial evidence that ISO ameliorates scopolamine-induced memory and cognitive impairments partly by restoring the cholinergic system, antioxidant defense, and p-CREB/BDNF signaling pathway, thereby exhibiting memory-enhancing activities.	homoorientin	48-51	cAMP responsive element binding protein 1	Mus musculus	188-192
31350730-9	2019	Thus, our results provide initial evidence that ISO ameliorates scopolamine-induced memory and cognitive impairments partly by restoring the cholinergic system, antioxidant defense, and p-CREB/BDNF signaling pathway, thereby exhibiting memory-enhancing activities.	Scopolamine	64-75	cAMP responsive element binding protein 1	Mus musculus	188-192
31166615-12	2019	CONCLUSIONS AND IMPLICATIONS: CREB transcriptionally up-regulates MPC1 to provide pyruvate for gluconeogenesis.	Pyruvic Acid	82-90	cAMP responsive element binding protein 1	Mus musculus	30-34
31166615-13	2019	Rb1 reduced cAMP formation which consequently reduced CREB-mediated MPC1 induction and thereby might contribute to limiting pyruvate-dependent HGP.	Pyruvic Acid	124-132	cAMP responsive element binding protein 1	Mus musculus	54-58
31166615-13	2019	Rb1 reduced cAMP formation which consequently reduced CREB-mediated MPC1 induction and thereby might contribute to limiting pyruvate-dependent HGP.	Cyclic AMP	12-16	cAMP responsive element binding protein 1	Mus musculus	54-58
31389584-13	2019	CONCLUSIONS: Astaxanthin activates the cAMP/PKA/CREB signaling pathway by increasing the cAMP concentration in brain tissues, ultimately promoting the axonal regeneration in the cerebral cortex and improving the motor function.	astaxanthine	13-24	cAMP responsive element binding protein 1	Mus musculus	48-52
31389584-13	2019	CONCLUSIONS: Astaxanthin activates the cAMP/PKA/CREB signaling pathway by increasing the cAMP concentration in brain tissues, ultimately promoting the axonal regeneration in the cerebral cortex and improving the motor function.	Cyclic AMP	39-43	cAMP responsive element binding protein 1	Mus musculus	48-52
31389584-13	2019	CONCLUSIONS: Astaxanthin activates the cAMP/PKA/CREB signaling pathway by increasing the cAMP concentration in brain tissues, ultimately promoting the axonal regeneration in the cerebral cortex and improving the motor function.	Cyclic AMP	89-93	cAMP responsive element binding protein 1	Mus musculus	48-52
31330909-0	2019	Neurological Enhancement Effects of Melatonin against Brain Injury-Induced Oxidative Stress, Neuroinflammation, and Neurodegeneration via AMPK/CREB Signaling.	Melatonin	36-45	cAMP responsive element binding protein 1	Mus musculus	143-147
31078920-14	2019	Moreover, phosphorylation of ERK1/2 and CREB was increased after METH and LPS exposure but decreased by SCH-23390.	Methamphetamine	65-69	cAMP responsive element binding protein 1	Mus musculus	40-44
31211521-6	2019	Activity of the cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB)-brain-derived neurotrophic factor (BDNF) pathway in the prefrontal cortex (PFC) and hippocampus (HP) was increased, as well as neurogenesis in the subgranular zone of the hippocampus.	Cyclic AMP	16-46	cAMP responsive element binding protein 1	Mus musculus	88-92
31211521-6	2019	Activity of the cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB)-brain-derived neurotrophic factor (BDNF) pathway in the prefrontal cortex (PFC) and hippocampus (HP) was increased, as well as neurogenesis in the subgranular zone of the hippocampus.	Cyclic AMP	48-52	cAMP responsive element binding protein 1	Mus musculus	88-92
31415077-9	2019	The replenishment of NMN or NAD+ partially slowed down corneal nerve fiber degeneration, reduced the epithelial defect in denervated mice, and improved apoptosis induction in FK866-treated cells by restoring the activation levels of SIRT1, AKT, and CREB.	NAD	28-32	cAMP responsive element binding protein 1	Mus musculus	249-253
31415077-9	2019	The replenishment of NMN or NAD+ partially slowed down corneal nerve fiber degeneration, reduced the epithelial defect in denervated mice, and improved apoptosis induction in FK866-treated cells by restoring the activation levels of SIRT1, AKT, and CREB.	N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide	175-180	cAMP responsive element binding protein 1	Mus musculus	249-253
30900142-6	2019	Finally, BoNT/A transiently increased the levels of phosphorylated extracellular signal-regulated kinase (p-ERK) and cAMP-response element binding protein (p-CREB), which were suppressed in the hippocampus of SRS mice.	Cyclic AMP	117-121	cAMP responsive element binding protein 1	Mus musculus	158-162
30900142-7	2019	Collectively, these results demonstrated that BoNT/A treatment has anti-depressant-like activity in mice, and this is associated with increased 5-HT levels and the activation of BDNF/ERK/CREB pathways in the hippocampus, supporting further investigation of BoNT/A therapy in depression.	bont	46-50	cAMP responsive element binding protein 1	Mus musculus	187-191
31348437-8	2019	Consistently, inhibition of PKA-CREB decreased PACAP-promoted YAP expression in primary hepatocytes culture, and made them vulnerable to H2O2 stress in vitro.	Hydrogen Peroxide	137-141	cAMP responsive element binding protein 1	Mus musculus	32-36
31330909-9	2019	These findings provide evidence, for the first time, that rmTBI induces brain energy imbalance and reduces neuronal cell survival, and that melatonin treatment overcomes energy depletion and protects against brain damage via the regulation of p-AMPK/p-CREB signaling pathways in the mouse brain.	Melatonin	140-149	cAMP responsive element binding protein 1	Mus musculus	252-256
31379571-5	2019	The results showed that the BSYS-containing serum markedly increased cell viability and increased the levels of growth associated protein (GAP)-43, phosphorylated (p)-cAMP-response element binding protein (CREB), BDNF, TrkB, and p-PI3K.	bsys	28-32	cAMP responsive element binding protein 1	Mus musculus	206-210
31379571-7	2019	Furthermore, the effects of BSYS on cell viability, GAP-43, p-CREB, and neurite outgrowth were clearly inhibited by LY294002, a specific antagonist of the PI3K signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	cAMP responsive element binding protein 1	Mus musculus	62-66
30947040-7	2019	Following prolonged exposure, MC-LR significantly upregulated the ratio of proBDNF to BDNF by downregulating the tPA levels, thereby activating downstream signaling pathways to improve the expression of p-JNK, and c-Jun while to inhibit the expression of p-Creb and p-PKC.	cyanoginosin LR	30-35	cAMP responsive element binding protein 1	Mus musculus	257-261
30933849-7	2019	Furthermore, using siRNA approach we found that silencing of the transcription factor Creb abrogates the Salmeterol-mediated production of IL-10 in LPS-activated BV2 cells, but silencing of beta-arrestin2 with Arrb2 siRNA did not.	Salmeterol Xinafoate	105-115	cAMP responsive element binding protein 1	Mus musculus	86-90
30936011-0	2019	Downregulation of A2AR by siRNA loaded PEG-chitosan-lactate nanoparticles restores the T cell mediated anti-tumor responses through blockage of PKA/CREB signaling pathway.	peg-chitosan	39-51	cAMP responsive element binding protein 1	Mus musculus	148-152
30936011-0	2019	Downregulation of A2AR by siRNA loaded PEG-chitosan-lactate nanoparticles restores the T cell mediated anti-tumor responses through blockage of PKA/CREB signaling pathway.	Lactic Acid	52-59	cAMP responsive element binding protein 1	Mus musculus	148-152
31300736-4	2019	This study assessed the anti-oxidative effect, the expression of BDNF and antioxidant enzymes, as well as the activation of cAMP response element binding (CREB) and extracellular signal-regulated kinase (ERK) signal transduction pathways assess using a hippocampal cell line (HT-22) and mouse organotypic hippocampal tissues by PBMT (LED, 660 nm, 20 mW/cm2).	Cyclic AMP	124-128	cAMP responsive element binding protein 1	Mus musculus	155-159
31085607-6	2019	p75NTR deletion preserved hippocampal structural and functional plasticity by preventing SD-mediated effects on hippocampal cAMP-CREB-BDNF, cAMP-PKA-LIMK1-cofilin, and RhoA-ROCK2 pathways.	Cyclic AMP	124-128	cAMP responsive element binding protein 1	Mus musculus	129-133
31354429-10	2019	Notably, early clenbuterol treatment alleviated sepsis-induced cognitive deficits by polarizing microglia toward an anti-inflammatory phenotype, reducing proinflammatory cytokines including IL-1beta, TNF-alpha, and up-regulating CREB/BDNF, PSD95, and GluN2B.	Clenbuterol	15-26	cAMP responsive element binding protein 1	Mus musculus	229-233
31354429-11	2019	Intriguingly, delayed clenbuterol treatment also improved cognitive impairments by normalization of hippocampal CREB/BDNF, PSD95, and GluN2B.	Clenbuterol	22-33	cAMP responsive element binding protein 1	Mus musculus	112-116
31308631-13	2019	The expressions of p-P38, p-CREB, and MMP13 were all upregulated in osteoarthritic cartilage or anisomycin-induced chondrocytes, suggesting that the P38/CREB/MMP13 axis may play a role in the progression of OA.	Anisomycin	96-106	cAMP responsive element binding protein 1	Mus musculus	28-32
31308631-13	2019	The expressions of p-P38, p-CREB, and MMP13 were all upregulated in osteoarthritic cartilage or anisomycin-induced chondrocytes, suggesting that the P38/CREB/MMP13 axis may play a role in the progression of OA.	Anisomycin	96-106	cAMP responsive element binding protein 1	Mus musculus	153-157
31140860-7	2019	Being a multifunctional molecule, aspirin stimulates the activation of cAMP-response element-binding (CREB) to promote the recruitment of CREB to the IL-11 gene promoter and stimulate the transcription of IL-11 in splenocytes.	Aspirin	34-41	cAMP responsive element binding protein 1	Mus musculus	71-100
30927672-4	2019	In addition, our results showed that exposure to 10-3, 10-4, and 10-5 moL/l NaF increased GSTO1 mRNA and protein expression, but decreased CREB and BDNF expression levels in a dose and time-dependent manner.	Sodium Fluoride	76-79	cAMP responsive element binding protein 1	Mus musculus	139-143
30927672-6	2019	We have shown that various NaF doses affected the learning and memory ability by down-regulation the expressions of CREB, BDNF, NCAM and SCF.	Sodium Fluoride	27-30	cAMP responsive element binding protein 1	Mus musculus	116-120
31140860-7	2019	Being a multifunctional molecule, aspirin stimulates the activation of cAMP-response element-binding (CREB) to promote the recruitment of CREB to the IL-11 gene promoter and stimulate the transcription of IL-11 in splenocytes.	Aspirin	34-41	cAMP responsive element binding protein 1	Mus musculus	102-106
31140860-7	2019	Being a multifunctional molecule, aspirin stimulates the activation of cAMP-response element-binding (CREB) to promote the recruitment of CREB to the IL-11 gene promoter and stimulate the transcription of IL-11 in splenocytes.	Aspirin	34-41	cAMP responsive element binding protein 1	Mus musculus	138-142
31140860-8	2019	Therefore, it appears that low-dose aspirin protects EAE via CREB-mediated stimulation of IL-11-Treg pathway and that aspirin may have therapeutic importance in MS.	Aspirin	36-43	cAMP responsive element binding protein 1	Mus musculus	61-65
30417358-13	2019	Altogether, the present study revealed that A2aR signaling through PKA/Akt/CREB mediators alleviated TM cytotoxicity effects in MIN6 beta cells.	Tunicamycin	101-103	cAMP responsive element binding protein 1	Mus musculus	75-79
31077737-0	2019	Cognitive-enhancing and ameliorative effects of acanthoside B in a scopolamine-induced amnesic mouse model through regulation of oxidative/inflammatory/cholinergic systems and activation of the TrkB/CREB/BDNF pathway.	acanthoside B	48-61	cAMP responsive element binding protein 1	Mus musculus	199-203
30991050-5	2019	CoQ10 down-regulated the melanin synthesis in alpha-MSH-stimulated B16-F10 cells by suppressing the MITF expression by down regulating the cAMP mediated CREB signaling cascades.	coenzyme Q10	0-5	cAMP responsive element binding protein 1	Mus musculus	153-157
30874970-6	2019	This SCT-induced transcriptional regulation of Bcl-2 and Bcl-xL was dependent on the cyclic AMP (cAMP) response element-binding protein (CREB), which is a key survival factor at the convergence of multiple signaling cascades.	Cyclic AMP	85-95	cAMP responsive element binding protein 1	Mus musculus	137-141
30874970-6	2019	This SCT-induced transcriptional regulation of Bcl-2 and Bcl-xL was dependent on the cyclic AMP (cAMP) response element-binding protein (CREB), which is a key survival factor at the convergence of multiple signaling cascades.	Cyclic AMP	97-101	cAMP responsive element binding protein 1	Mus musculus	137-141
30874970-7	2019	We further demonstrated that activation of CREB by SCT was mediated by cAMP/protein kinase A (PKA) and mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase 1/2 (ERK1/2) cascades.	Cyclic AMP	71-75	cAMP responsive element binding protein 1	Mus musculus	43-47
31042565-6	2019	When exposed to low nanomolar concentrations of ouabain, they respond with stimulation of Erk1/2, CREB, and ATF-1 phosphorylation, LD enlargement, and perilipin2 mobilization to the LDs.	Ouabain	48-55	cAMP responsive element binding protein 1	Mus musculus	98-102
30742994-8	2019	Celastrol also inhibited gluconeogenic activity through a CREB/PGC-1alpha pathway.	celastrol	0-9	cAMP responsive element binding protein 1	Mus musculus	58-62
30991050-5	2019	CoQ10 down-regulated the melanin synthesis in alpha-MSH-stimulated B16-F10 cells by suppressing the MITF expression by down regulating the cAMP mediated CREB signaling cascades.	Cyclic AMP	139-143	cAMP responsive element binding protein 1	Mus musculus	153-157
30525243-10	2019	Further analysis indicated that BMP9 upregulates cyclooxygenase-2 (COX-2) and phosphorylation of cAMP-responsive element binding (p-CREB) simultaneously.	Cyclic AMP	97-101	cAMP responsive element binding protein 1	Mus musculus	132-136
31308794-8	2019	ELS-exposed D2+/- mice had decreased levels of BDNF, TrkB, phospho-ERK1/2 and phospho-CREB in the dorsal striatum.	N-[(2S,3S,4R)-3,4-dihydroxy-8-oxo-8-[(4-pentylphenyl)amino]-1-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}octan-2-yl]hexacosanamide	0-3	cAMP responsive element binding protein 1	Mus musculus	86-90
31006109-9	2019	Neuronal cells treated with single AAAs in vitro further demonstrated that tryptophan and tyrosine enhanced 5-HT and dopamine synthesis, respectively, and promoted BDNF expression partly through the 5-HT1A/DRD1-CREB pathway.	Tryptophan	75-85	cAMP responsive element binding protein 1	Mus musculus	211-215
30478761-4	2019	Similarly, melatonin ameliorated oxidative stress-mediated JNK activation, enhanced Akt/ERK/CREB signaling, promoted cell survival and proliferation, and promoted memory processes.	Melatonin	11-20	cAMP responsive element binding protein 1	Mus musculus	92-96
30187283-7	2019	While investigating mechanisms, we found the presence of cAMP response element (CRE) in the promoter of TH gene and the rapid induction of cAMP response element binding (CREB) activation by aspirin in dopaminergic neuronal cells.	Aspirin	190-197	cAMP responsive element binding protein 1	Mus musculus	139-168
30187283-7	2019	While investigating mechanisms, we found the presence of cAMP response element (CRE) in the promoter of TH gene and the rapid induction of cAMP response element binding (CREB) activation by aspirin in dopaminergic neuronal cells.	Aspirin	190-197	cAMP responsive element binding protein 1	Mus musculus	170-174
30187283-8	2019	Aspirin treatment also increased the level of phospho-CREB in the nigra of C57/BL6 mice.	Aspirin	0-7	cAMP responsive element binding protein 1	Mus musculus	54-58
30187283-9	2019	The abrogation of aspirin-induced expression of TH by siRNA knockdown of CREB and the recruitment of CREB to the TH gene promoter by aspirin suggest that aspirin stimulates the transcription of TH in dopaminergic neurons via CREB.	Aspirin	18-25	cAMP responsive element binding protein 1	Mus musculus	73-77
30187283-9	2019	The abrogation of aspirin-induced expression of TH by siRNA knockdown of CREB and the recruitment of CREB to the TH gene promoter by aspirin suggest that aspirin stimulates the transcription of TH in dopaminergic neurons via CREB.	Aspirin	133-140	cAMP responsive element binding protein 1	Mus musculus	101-105
30187283-9	2019	The abrogation of aspirin-induced expression of TH by siRNA knockdown of CREB and the recruitment of CREB to the TH gene promoter by aspirin suggest that aspirin stimulates the transcription of TH in dopaminergic neurons via CREB.	Aspirin	133-140	cAMP responsive element binding protein 1	Mus musculus	101-105
30187283-9	2019	The abrogation of aspirin-induced expression of TH by siRNA knockdown of CREB and the recruitment of CREB to the TH gene promoter by aspirin suggest that aspirin stimulates the transcription of TH in dopaminergic neurons via CREB.	Aspirin	133-140	cAMP responsive element binding protein 1	Mus musculus	101-105
31006109-9	2019	Neuronal cells treated with single AAAs in vitro further demonstrated that tryptophan and tyrosine enhanced 5-HT and dopamine synthesis, respectively, and promoted BDNF expression partly through the 5-HT1A/DRD1-CREB pathway.	Tyrosine	90-98	cAMP responsive element binding protein 1	Mus musculus	211-215
30187283-9	2019	The abrogation of aspirin-induced expression of TH by siRNA knockdown of CREB and the recruitment of CREB to the TH gene promoter by aspirin suggest that aspirin stimulates the transcription of TH in dopaminergic neurons via CREB.	Aspirin	133-140	cAMP responsive element binding protein 1	Mus musculus	101-105
31141948-0	2019	Elaeagnus glabra f. oxyphylla Attenuates Scopolamine-Induced Learning and Memory Impairments in Mice by Improving Cholinergic Transmission via Activation of CREB/NGF Signaling.	Scopolamine	41-52	cAMP responsive element binding protein 1	Mus musculus	157-161
31083279-8	2019	Reduced apoptosis and increased phosphorylation of CREB and Erk were observed in VAPA-Rab31-overexpressing cells after bortezomib treatment.	Bortezomib	119-129	cAMP responsive element binding protein 1	Mus musculus	51-55
30839193-9	2019	Interestingly, we also found that BHDPC enhanced phosphorylation of protein kinase A (PKA) and cAMP-response element-binding protein (CREB).	bhdpc	34-39	cAMP responsive element binding protein 1	Mus musculus	95-132
30839193-9	2019	Interestingly, we also found that BHDPC enhanced phosphorylation of protein kinase A (PKA) and cAMP-response element-binding protein (CREB).	bhdpc	34-39	cAMP responsive element binding protein 1	Mus musculus	134-138
31257810-17	2019	U0126 did not affect Ex-4-mediated CERB activation, and LY294002 significantly reduced Ex-4-mediated CREB activation (P&lt;0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	56-64	cAMP responsive element binding protein 1	Mus musculus	101-105
31257810-17	2019	U0126 did not affect Ex-4-mediated CERB activation, and LY294002 significantly reduced Ex-4-mediated CREB activation (P&lt;0.01).	ex-4	87-91	cAMP responsive element binding protein 1	Mus musculus	101-105
30914305-7	2019	Chronic AICAR treatment suppressed the prolonged immobility of OBX mice in the TST and FST, and increased the levels of phosphorylated AMPK, PKCzeta, NF-kappaB, CREB, and BDNF.	acadesine	8-13	cAMP responsive element binding protein 1	Mus musculus	161-165
31083279-9	2019	Elevated Bcl-2 level via activated CREB contributed to the resistance to the bortezomib-induced apoptosis.	Bortezomib	77-87	cAMP responsive element binding protein 1	Mus musculus	35-39
30856465-8	2019	The cAMP-response element binding protein (CREB) was identified as the target transcription factor involved in the RSV mediated upregulation of eNOS expression.	Resveratrol	115-118	cAMP responsive element binding protein 1	Mus musculus	4-41
30721627-0	2019	Spaceflight/microgravity inhibits the proliferation of hematopoietic stem cells by decreasing Kit-Ras/cAMP-CREB pathway networks as evidenced by RNA-Seq assays.	Cyclic AMP	102-106	cAMP responsive element binding protein 1	Mus musculus	107-111
30703414-8	2019	EB148 facilitated cAMP accumulation, and mediated a sustained activation of extracellular signal-regulated kinases (ERKs) and cAMP response element-binding protein (CREB).	EB148	0-5	cAMP responsive element binding protein 1	Mus musculus	126-163
30703414-8	2019	EB148 facilitated cAMP accumulation, and mediated a sustained activation of extracellular signal-regulated kinases (ERKs) and cAMP response element-binding protein (CREB).	EB148	0-5	cAMP responsive element binding protein 1	Mus musculus	165-169
30856465-11	2019	In vivo, treatment with RSV improves endothelial dysfunction and attenuates atherosclerotic plaque formation in apoE-/- mice through PKA-CREB-dependent pathway.	Resveratrol	24-27	cAMP responsive element binding protein 1	Mus musculus	137-141
30503507-2	2019	Salt-inducible kinase (SIK) is a kinase that regulates the nuclear translocation of cyclic adenosine monophosphate response element binding protein (CREB)-regulated transcription coactivator (CRTC) by phosphorylation.	Adenosine	91-100	cAMP responsive element binding protein 1	Mus musculus	149-153
30820818-14	2019	The results of MWM and NORT, as well as the levels of Creb1, Gap-43, BDNF, CaMKII, and ERKs were markedly reversed in the moderate- and low-dose of Ator treated groups.	Atorvastatin	148-152	cAMP responsive element binding protein 1	Mus musculus	54-59
30987288-8	2019	It also attenuated the phosphorylation of cAMP-responsive element binding protein (CREB) stimulated by forskolin.	Colforsin	103-112	cAMP responsive element binding protein 1	Mus musculus	42-81
30709903-0	2019	Iron down-regulates leptin by suppressing protein O-GlcNAc modification in adipocytes, resulting in decreased levels of O-glycosylated CREB.	Iron	0-4	cAMP responsive element binding protein 1	Mus musculus	135-139
30709903-8	2019	Of note, iron increased the occupancy of pCREB and decreased the occupancy of O-GlcNAcylated CREB on the leptin promoter.	Iron	9-13	cAMP responsive element binding protein 1	Mus musculus	42-46
30709903-10	2019	We conclude that iron down-regulates leptin by decreasing CREB glycosylation, resulting in increased CREB phosphorylation and leptin promoter occupancy by pCREB.	Iron	17-21	cAMP responsive element binding protein 1	Mus musculus	58-62
30709903-10	2019	We conclude that iron down-regulates leptin by decreasing CREB glycosylation, resulting in increased CREB phosphorylation and leptin promoter occupancy by pCREB.	Iron	17-21	cAMP responsive element binding protein 1	Mus musculus	101-105
30987288-0	2019	Luteolin 7-Sulfate Attenuates Melanin Synthesis through Inhibition of CREB- and MITF-Mediated Tyrosinase Expression.	Luteolin 7-sulfate	0-18	cAMP responsive element binding protein 1	Mus musculus	70-74
30987288-0	2019	Luteolin 7-Sulfate Attenuates Melanin Synthesis through Inhibition of CREB- and MITF-Mediated Tyrosinase Expression.	Melanins	30-37	cAMP responsive element binding protein 1	Mus musculus	70-74
30987288-8	2019	It also attenuated the phosphorylation of cAMP-responsive element binding protein (CREB) stimulated by forskolin.	Colforsin	103-112	cAMP responsive element binding protein 1	Mus musculus	83-87
30987288-10	2019	This study demonstrates that luteolin 7-sulfate attenuates TYR gene expression through the intervention of a CREB- and MITF-mediated signaling pathway, leading to the decreased melanin synthesis.	Luteolin 7-sulfate	29-47	cAMP responsive element binding protein 1	Mus musculus	109-113
30875211-9	2019	EGCG reduced p-PKA-T197/T-PKA and p-CREB-S133/T-CREB levels by 39 and 20%, blocked p-FoxO1-S273, and suppressed nuclear FoxO1 translocation, suggesting that FoxO1 and CREB were possible downstream targets.	epigallocatechin gallate	0-4	cAMP responsive element binding protein 1	Mus musculus	36-40
30875211-9	2019	EGCG reduced p-PKA-T197/T-PKA and p-CREB-S133/T-CREB levels by 39 and 20%, blocked p-FoxO1-S273, and suppressed nuclear FoxO1 translocation, suggesting that FoxO1 and CREB were possible downstream targets.	epigallocatechin gallate	0-4	cAMP responsive element binding protein 1	Mus musculus	48-52
30987288-10	2019	This study demonstrates that luteolin 7-sulfate attenuates TYR gene expression through the intervention of a CREB- and MITF-mediated signaling pathway, leading to the decreased melanin synthesis.	Melanins	177-184	cAMP responsive element binding protein 1	Mus musculus	109-113
30875211-9	2019	EGCG reduced p-PKA-T197/T-PKA and p-CREB-S133/T-CREB levels by 39 and 20%, blocked p-FoxO1-S273, and suppressed nuclear FoxO1 translocation, suggesting that FoxO1 and CREB were possible downstream targets.	epigallocatechin gallate	0-4	cAMP responsive element binding protein 1	Mus musculus	48-52
31138987-5	2019	The siRNA-mediated knockdown of Sirt1 in HT22 cells decreased Bdnf4, a splicing variant of Bdnf, and Creb expression, suggesting that Sirt1 plays a role in L-EV-induced increase of BDNF and CREB expression.	l-ev	156-160	cAMP responsive element binding protein 1	Mus musculus	101-105
30639733-3	2019	Olfr43 was expressed in mouse hepatocytes, and Olfr43 activation by a known ligand, (-)-carvone, stimulated cAMP response element-binding protein (CREB) activity.	carvone	84-95	cAMP responsive element binding protein 1	Mus musculus	108-145
30639733-3	2019	Olfr43 was expressed in mouse hepatocytes, and Olfr43 activation by a known ligand, (-)-carvone, stimulated cAMP response element-binding protein (CREB) activity.	carvone	84-95	cAMP responsive element binding protein 1	Mus musculus	147-151
31138987-5	2019	The siRNA-mediated knockdown of Sirt1 in HT22 cells decreased Bdnf4, a splicing variant of Bdnf, and Creb expression, suggesting that Sirt1 plays a role in L-EV-induced increase of BDNF and CREB expression.	l-ev	156-160	cAMP responsive element binding protein 1	Mus musculus	190-194
30956031-0	2019	Fargesin inhibits melanin synthesis in murine malignant and immortalized melanocytes by regulating PKA/CREB and P38/MAPK signaling pathways.	fargesin	0-8	cAMP responsive element binding protein 1	Mus musculus	103-107
31057653-8	2019	Furthermore, production of anti-inflammatory cytokine IL-10 was increased and Heme oxygenase-1 (HO-1) was upregulated via the nuclear factor-E2-related factor 2 (NRF2)/cAMP response element-binding protein (CREB) pathway, collectively indicating the neuroprotective effects of GBH.	Cyclic AMP	168-172	cAMP responsive element binding protein 1	Mus musculus	207-211
31057653-8	2019	Furthermore, production of anti-inflammatory cytokine IL-10 was increased and Heme oxygenase-1 (HO-1) was upregulated via the nuclear factor-E2-related factor 2 (NRF2)/cAMP response element-binding protein (CREB) pathway, collectively indicating the neuroprotective effects of GBH.	gbh	277-280	cAMP responsive element binding protein 1	Mus musculus	207-211
30544148-9	2019	Treatment with cell-permeable cGMP also enhanced the CREB phosphorylation.	Cyclic GMP	30-34	cAMP responsive element binding protein 1	Mus musculus	53-57
30956031-10	2019	Fargesin also effectively inhibited the activation of PKA/CREB and p38 MAPK as well as their interactions, which in turn is responsible for the expression of MITF and melanogenic enzymes.	fargesin	0-8	cAMP responsive element binding protein 1	Mus musculus	58-62
30956031-11	2019	CONCLUSIONS: These results show that fargesin can function as an anti-melanogenic agent, at least in part, by inhibiting PKA/CREB and p38/MAPK signaling pathways.	fargesin	37-45	cAMP responsive element binding protein 1	Mus musculus	125-129
30874310-2	2019	In this issue of Journal of Neurochemistry, Ni and colleagues investigate the role of cyclic adenosine monophosphate response element-binding protein (CREB)-dependent signaling in the hippocampus on depressive-like behaviors.	Cyclic AMP	86-116	cAMP responsive element binding protein 1	Mus musculus	151-155
30990755-11	2019	These results suggest that suitable levels of methionine and choline are essential for the maintenance of hippocampal neurogenesis in mice and affect NSC proliferation and differentiation through phosphorylation of CREB.	Methionine	46-56	cAMP responsive element binding protein 1	Mus musculus	215-219
30990755-11	2019	These results suggest that suitable levels of methionine and choline are essential for the maintenance of hippocampal neurogenesis in mice and affect NSC proliferation and differentiation through phosphorylation of CREB.	Choline	61-68	cAMP responsive element binding protein 1	Mus musculus	215-219
30610438-0	2019	Roflumilast ameliorates cognitive impairment in APP/PS1 mice via cAMP/CREB/BDNF signaling and anti-neuroinflammatory effects.	Roflumilast	0-11	cAMP responsive element binding protein 1	Mus musculus	70-74
30734800-7	2019	Furthermore, alpha-ionone increased cAMP concentration and enhanced its downstream PKA-CREB signaling in skeletal muscle of mice fed high-fat diet.	alpha-ionone	13-25	cAMP responsive element binding protein 1	Mus musculus	87-91
30610438-6	2019	In addition, roflumilast increased the cAMP, phosphorylated cAMP response-element binding protein (p-CREB) and brain-derived neurotrophic factor (BDNF) levels, and reduced the nuclear translocation of nuclear factor-kappa B (NF-kappaB) p65, and proinflammatory cytokine (IL-6, TNF-a and IL-1beta) levels in the hippocampus of APP/PS1 transgenic mice.	Roflumilast	13-24	cAMP responsive element binding protein 1	Mus musculus	101-105
30610438-7	2019	In conclusion, these findings suggest that roflumilast can enhance cognitive function in APP/PS1 transgenic mice, which may be related to its stimulation of the cAMP/CREB/BDNF pathway and anti-neuroinflammatory effects.	Roflumilast	43-54	cAMP responsive element binding protein 1	Mus musculus	166-170
30783436-7	2019	The phosphorylation of cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) was assessed by western blot analysis.	Cyclic AMP	23-53	cAMP responsive element binding protein 1	Mus musculus	95-99
30783436-7	2019	The phosphorylation of cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) was assessed by western blot analysis.	Cyclic AMP	55-59	cAMP responsive element binding protein 1	Mus musculus	95-99
30783436-11	2019	Furthermore, sodium butyrate also increased the accumulation of intracellular ATP and induced the phosphorylation of CREB in mouse hepatocytes.	Butyric Acid	13-28	cAMP responsive element binding protein 1	Mus musculus	117-121
30783436-12	2019	In conclusion, the present study suggested that butyrate stimulates hepatic gluconeogenesis and induces gluconeogenic gene expression as a substrate and cAMP/CREB signaling activator.	Butyrates	48-56	cAMP responsive element binding protein 1	Mus musculus	158-162
30701598-7	2019	In addition, we found KF could boost brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B (TrkB)/cAMP response element-binding (CREB) protein signal in the hippocampus.	Cyclic AMP	115-119	cAMP responsive element binding protein 1	Mus musculus	146-150
30841431-6	2019	This was through the phosphorylation of 3"-5"-cyclic adenosine monophosphate response element-binding protein (CREB) in beta-cells, hence activating CREB downstream anti-apoptotic genes, Bcl-2 and Bcl-xL.	3"-5"-cyclic adenosine monophosphate	40-76	cAMP responsive element binding protein 1	Mus musculus	111-115
30841431-6	2019	This was through the phosphorylation of 3"-5"-cyclic adenosine monophosphate response element-binding protein (CREB) in beta-cells, hence activating CREB downstream anti-apoptotic genes, Bcl-2 and Bcl-xL.	3"-5"-cyclic adenosine monophosphate	40-76	cAMP responsive element binding protein 1	Mus musculus	149-153
30768667-4	2019	Hourly pulses of ACTH stimulate dynamic increases in CREB phosphorylation (pCREB) and transcription of genes involved in critical steps of steroidogenesis including signal transduction (e.g., MRAP), cholesterol delivery (e.g., StAR), and steroid biosynthesis (e.g., CYP11A1), as well as those relating to transcriptional regulation of steroidogenic factors (e.g., SF-1 and Nur-77).	Cholesterol	199-210	cAMP responsive element binding protein 1	Mus musculus	53-57
30260029-9	2019	CREB-induced MEG3 upregulation increased gluconeogenic gene expression in high glucagon-treated primary hepatocytes, while MEG3 interference led to an opposite effect.	Glucagon	79-87	cAMP responsive element binding protein 1	Mus musculus	0-4
31165701-0	2019	Nanoparticulate TiO2 Induced Suppression of Spermatogenesis is Involved in Regulatory Dysfunction of the cAMP-CREB/CREM Signaling Pathway in Mice.	titanium dioxide	16-20	cAMP responsive element binding protein 1	Mus musculus	110-114
31165701-0	2019	Nanoparticulate TiO2 Induced Suppression of Spermatogenesis is Involved in Regulatory Dysfunction of the cAMP-CREB/CREM Signaling Pathway in Mice.	Cyclic AMP	105-109	cAMP responsive element binding protein 1	Mus musculus	110-114
31165701-2	2019	However, whether the suppression of spermatogenesis induced by nano-TiO2 is related to regulatory disturbances of the cAMP-CREB/CREM signaling pathway is not well investigated.	Cyclic AMP	118-122	cAMP responsive element binding protein 1	Mus musculus	123-127
31165701-5	2019	Furthermore, nano-TiO2 also induced significant reductions in protein expression including cyclic adenosine monophosphate content, protein kinase A, cAMP-responsive element modulator, p-cAMP-response element binding protein, lactate dehydrogenase-C, testis-specific protein kinase 1, and testicular specific CREM activator, and upregulation of protein expression including protein phosphatase, and transducer of regulated CREB 1, which may be associated with reductions of follicle stimulating hormone and luteinizing hormone levels.	titanium dioxide	18-22	cAMP responsive element binding protein 1	Mus musculus	422-428
31165701-6	2019	Together, the present study indicates that the reductions of FSH and LH concentrations and suppression of spermatogenesis in mice caused by nano-TiO2 may be associated with the dysfunctions of the cAMP-CREB/CREM signaling pathway.	titanium dioxide	145-149	cAMP responsive element binding protein 1	Mus musculus	202-206
31165701-6	2019	Together, the present study indicates that the reductions of FSH and LH concentrations and suppression of spermatogenesis in mice caused by nano-TiO2 may be associated with the dysfunctions of the cAMP-CREB/CREM signaling pathway.	Cyclic AMP	197-201	cAMP responsive element binding protein 1	Mus musculus	202-206
30741293-6	2019	Interestingly, further investigations demonstrated that SEC inhibited CUMS-induced activation of the nuclear factor kappa B (NF-kappaB) and NOD-like receptor protein 3 (NLRP3) inflammasomes pathways but upregulated brain-derived neurotrophic factor (BDNF) expression and promoted phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP-response element-binding protein (CREB) in hippocampal.	cums	70-74	cAMP responsive element binding protein 1	Mus musculus	347-384
30741293-6	2019	Interestingly, further investigations demonstrated that SEC inhibited CUMS-induced activation of the nuclear factor kappa B (NF-kappaB) and NOD-like receptor protein 3 (NLRP3) inflammasomes pathways but upregulated brain-derived neurotrophic factor (BDNF) expression and promoted phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP-response element-binding protein (CREB) in hippocampal.	cums	70-74	cAMP responsive element binding protein 1	Mus musculus	386-390
30204307-9	2019	Levels of PKA and CREB phosphorylation in PVN were increased at 4-hour post-MPTP, which were blocked by quinpirole, but not WIN552,12.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	76-80	cAMP responsive element binding protein 1	Mus musculus	18-22
30204307-9	2019	Levels of PKA and CREB phosphorylation in PVN were increased at 4-hour post-MPTP, which were blocked by quinpirole, but not WIN552,12.	Quinpirole	104-114	cAMP responsive element binding protein 1	Mus musculus	18-22
30204307-11	2019	CONCLUSION: The activation of dh-DA neurons regulates negatively HPA axis through targeting D2Rs of CRH neurons to enhance endocannabinoid release and inhibit PKA-CREB pathway.	dh-da	30-35	cAMP responsive element binding protein 1	Mus musculus	163-167
29935220-6	2019	RESULTS: IL-23 induces Ptgs2, encoding COX2 in TH17 cells, and produces PGE2, which acts back on the PGE receptors EP2 and EP4 in these cells and enhances IL-23-induced expression of an IL-23 receptor subunit gene, Il23r, by activating signal transducer and activator of transcription (STAT) 3, cAMP-responsive element binding protein 1, and nuclear factor kappa light chain enhancer of activated B cells (NF-kappaB) through cyclic AMP-protein kinase A signaling.	Dinoprostone	72-76	cAMP responsive element binding protein 1	Mus musculus	295-336
30374679-7	2019	Consistent with these results, ACR caused cognitive defects in the night period by down-regulating the ERK/cAMP response element-binding protein (CREB)/brain-derived neurotrophic factor (BDNF) signaling pathways and the expression of synaptosomal-related protein SNAP-25 and PSD-95.	Cyclic AMP	107-111	cAMP responsive element binding protein 1	Mus musculus	146-150
29341465-8	2019	Meanwhile, it hampered the protein kinase A (PKA)/cAMP response element-binding protein (CREB)/brain-derived neurotrophic factor (BDNF) signaling pathway in these brain regions.	Cyclic AMP	50-54	cAMP responsive element binding protein 1	Mus musculus	89-93
29948950-8	2019	Resveratrol also increased AMPK protein levels, then upregulating the SIRT1 pathway, as shown by the activation of PGC-1alpha and CREB in both mice, resulting in further beneficial changes.	Resveratrol	0-11	cAMP responsive element binding protein 1	Mus musculus	130-134
30426726-3	2019	The cAMP-CREB pathway, which is activated by GNAS mutations, is known to be closely associated with the occurrence of FD.	Cyclic AMP	4-8	cAMP responsive element binding protein 1	Mus musculus	9-13
30426726-10	2019	In summary, our study reveals that HDAC8 associates with FD phenotype and demonstrates the mechanisms regulated by cAMP-CREB1-HDAC8 pathway.	Cyclic AMP	115-119	cAMP responsive element binding protein 1	Mus musculus	120-125
32417838-8	2019	RESULTS: CREB knockdown induced mitochondrial reactive oxygen species production and apoptosis in primary neurons whereas CREB overexpression brought the opposite effects.	Reactive Oxygen Species	46-69	cAMP responsive element binding protein 1	Mus musculus	9-13
30687079-0	2018	Royal Jelly Alleviates Cognitive Deficits and beta-Amyloid Accumulation in APP/PS1 Mouse Model Via Activation of the cAMP/PKA/CREB/BDNF Pathway and Inhibition of Neuronal Apoptosis.	royal jelly	0-11	cAMP responsive element binding protein 1	Mus musculus	126-130
30687079-0	2018	Royal Jelly Alleviates Cognitive Deficits and beta-Amyloid Accumulation in APP/PS1 Mouse Model Via Activation of the cAMP/PKA/CREB/BDNF Pathway and Inhibition of Neuronal Apoptosis.	Cyclic AMP	117-121	cAMP responsive element binding protein 1	Mus musculus	126-130
31038580-3	2019	The results obtained using western blot analysis demonstrated that VUF-8430 induced a decrease in CREB and pCREB levels in the cerebellar vermis and prefrontal cortex, suggesting that this dose impaired the activation of cell signaling pathways in these structures.	S-(2-guanidylethyl)isothiourea	67-75	cAMP responsive element binding protein 1	Mus musculus	98-102
30695994-7	2019	Moreover, LDE-EA decreased p-CREB levels, which suggests that the inhibition of the cAMP/PKA/CREB pathways may be involved in the anti-melanogenic effect of LDE-EA.	Cyclic AMP	84-88	cAMP responsive element binding protein 1	Mus musculus	29-33
30695994-7	2019	Moreover, LDE-EA decreased p-CREB levels, which suggests that the inhibition of the cAMP/PKA/CREB pathways may be involved in the anti-melanogenic effect of LDE-EA.	Cyclic AMP	84-88	cAMP responsive element binding protein 1	Mus musculus	93-97
30669571-0	2019	Fucoidan-Fucoxanthin Ameliorated Cardiac Function via IRS1/GRB2/ SOS1, GSK3beta/CREB Pathways and Metabolic Pathways in Senescent Mice.	fucoidan-fucoxanthin	0-20	cAMP responsive element binding protein 1	Mus musculus	80-84
30669571-8	2019	Treatment with fucoidan and fucoxanthin reduced the expression levels of SOS1 and GRB2 while increasing GSK3beta, CREB and IRS1 proteins expression in the aging process.	fucoidan	15-23	cAMP responsive element binding protein 1	Mus musculus	114-118
30669571-8	2019	Treatment with fucoidan and fucoxanthin reduced the expression levels of SOS1 and GRB2 while increasing GSK3beta, CREB and IRS1 proteins expression in the aging process.	fucoxanthin	28-39	cAMP responsive element binding protein 1	Mus musculus	114-118
30503586-0	2019	Alternariol induced proliferation in primary mouse keratinocytes and inflammation in mouse skin is regulated via PGE2/EP2/cAMP/p-CREB signaling pathway.	Dinoprostone	113-117	cAMP responsive element binding protein 1	Mus musculus	129-133
30503586-5	2019	Western blot analysis showed that exposure of AOH lead to phosphorylation of CREB and increased the expression of COX-2, cyclin D1 as well as prostanoid EP2 receptor.	alternariol	46-49	cAMP responsive element binding protein 1	Mus musculus	77-81
30503586-8	2019	Collectively, our findings show that AOH can lead to dermal toxicity in mice by activating the EP2/cAMP/p-CREB signaling cascade.	alternariol	37-40	cAMP responsive element binding protein 1	Mus musculus	106-110
30503586-8	2019	Collectively, our findings show that AOH can lead to dermal toxicity in mice by activating the EP2/cAMP/p-CREB signaling cascade.	Cyclic AMP	99-103	cAMP responsive element binding protein 1	Mus musculus	106-110
32417838-11	2019	MitoQ treatment restored the expression of CREB and its downstream mediators, and prevented TLE-associated oxidative neuronal damage and memory deficits aggravated by CREB inhibition.	mitoquinone	0-5	cAMP responsive element binding protein 1	Mus musculus	43-47
32417838-11	2019	MitoQ treatment restored the expression of CREB and its downstream mediators, and prevented TLE-associated oxidative neuronal damage and memory deficits aggravated by CREB inhibition.	mitoquinone	0-5	cAMP responsive element binding protein 1	Mus musculus	167-171
32417838-14	2019	Mitochondria-specific antioxidants such as MitoQ may alleviate TLE-associated cognitive dysfunction through activation of CREB and its downstream signaling pathways.	mitoquinone	43-48	cAMP responsive element binding protein 1	Mus musculus	122-126
30544074-7	2019	Combined, our data show that withdrawal from chronic METH exposure induces anxiety and depression-like behavior associated with aberrant changes of proteins in BDNF-ERK-CREB pathway, providing new evidence for the involvement of BDNF pathway in the negative emotional states induced by withdrawal from METH.	Methamphetamine	53-57	cAMP responsive element binding protein 1	Mus musculus	169-173
30556190-0	2018	MicroRNA-205 affects mouse granulosa cell apoptosis and estradiol synthesis by targeting CREB1.	Estradiol	56-65	cAMP responsive element binding protein 1	Mus musculus	89-94
30556190-5	2018	Bioinformatics and luciferase reporter assays revealed that the gene encoding cyclic AMP response element (CRE)-binding protein 1 (CREB1) was a direct target of miR-205 in mGCs.	Cyclic AMP	78-88	cAMP responsive element binding protein 1	Mus musculus	131-136
30546087-8	2018	Nuclear PKA appeared to mediate the inhibitory phosphorylation of salt-inducible kinase 2 (SIK2) at serine-358 and thereby to alleviate the inhibitory phosphorylation of the CREB co-activator p300 at serine-89.	Serine	100-106	cAMP responsive element binding protein 1	Mus musculus	174-178
30546087-8	2018	Nuclear PKA appeared to mediate the inhibitory phosphorylation of salt-inducible kinase 2 (SIK2) at serine-358 and thereby to alleviate the inhibitory phosphorylation of the CREB co-activator p300 at serine-89.	Serine	200-206	cAMP responsive element binding protein 1	Mus musculus	174-178
30546087-11	2018	Together, our results indicate that high-dose GluOC triggers necroptosis through upregulation of FasL at the plasma membrane in a manner dependent of activation of CREB-p300, followed by the activation of Fas signaling in neighboring adipocytes.	gluoc	46-51	cAMP responsive element binding protein 1	Mus musculus	164-168
30546087-2	2018	We previously showed that low-dose (&lt;=10 ng/ml) GluOC induces the expression of adiponectin and peroxisome proliferator-activated receptor gamma (PPARgamma) via a cAMP-PKA-ERK-CREB signaling pathway in 3T3-L1 adipocytes.	gluoc	51-56	cAMP responsive element binding protein 1	Mus musculus	179-183
30546087-7	2018	Cytosolic PKA induced phosphorylation of cAMP response element-binding protein (CREB) at serine-133 via extracellular signal-regulated kinase (ERK).	Serine	89-95	cAMP responsive element binding protein 1	Mus musculus	41-78
30291886-4	2018	These results were consistent with an attenuation of the action of fructose on hippocampal CREB levels.	Fructose	67-75	cAMP responsive element binding protein 1	Mus musculus	91-95
30546087-7	2018	Cytosolic PKA induced phosphorylation of cAMP response element-binding protein (CREB) at serine-133 via extracellular signal-regulated kinase (ERK).	Serine	89-95	cAMP responsive element binding protein 1	Mus musculus	80-84
30291886-5	2018	Fructose also reduced the levels of CREB and BDNF in primary hippocampal neuronal cultures.	Fructose	0-8	cAMP responsive element binding protein 1	Mus musculus	36-40
30291886-6	2018	Bgn siRNA treatment abolished these effects of fructose on CREB and BDNF levels, in conjunction with a reduction in a fructose-related increase in Bgn protein.	Fructose	47-55	cAMP responsive element binding protein 1	Mus musculus	59-63
30064084-5	2018	The inhibitory effects of MC-LR on GnRH synthesis were identified to be associated with activation of the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA)/cAMP response element-binding protein (CREB)/c-Fos signaling pathway.	mc-lr	26-31	cAMP responsive element binding protein 1	Mus musculus	206-210
30482850-6	2018	Aspirin also increased the transcription of Il11 mediated by the transcription factor CREB, which was necessary for the generation of Tregs Neutralization of IL-11 negated the effects of aspirin on Treg development and exacerbated EAE.	Aspirin	0-7	cAMP responsive element binding protein 1	Mus musculus	86-90
30482850-6	2018	Aspirin also increased the transcription of Il11 mediated by the transcription factor CREB, which was necessary for the generation of Tregs Neutralization of IL-11 negated the effects of aspirin on Treg development and exacerbated EAE.	Aspirin	187-194	cAMP responsive element binding protein 1	Mus musculus	86-90
30482850-6	2018	Aspirin also increased the transcription of Il11 mediated by the transcription factor CREB, which was necessary for the generation of Tregs Neutralization of IL-11 negated the effects of aspirin on Treg development and exacerbated EAE.	treg	134-138	cAMP responsive element binding protein 1	Mus musculus	86-90
30598686-7	2018	Therefore, it can be concluded that the fermented extract exerts memory-improving effects in the hippocampus of scopolamine-treated mice through an initial increase in ERK signaling and a sequential induction of the expression of p-CREB and BDNF, and these effects are related to the antioxidant activities of beta-carotene and other components.	Scopolamine	112-123	cAMP responsive element binding protein 1	Mus musculus	232-236
30064084-5	2018	The inhibitory effects of MC-LR on GnRH synthesis were identified to be associated with activation of the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA)/cAMP response element-binding protein (CREB)/c-Fos signaling pathway.	Cyclic AMP	106-136	cAMP responsive element binding protein 1	Mus musculus	206-210
30064084-5	2018	The inhibitory effects of MC-LR on GnRH synthesis were identified to be associated with activation of the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA)/cAMP response element-binding protein (CREB)/c-Fos signaling pathway.	Cyclic AMP	167-171	cAMP responsive element binding protein 1	Mus musculus	206-210
29803941-6	2018	In the Western blotting, the administration of SKF 38393 increased the phosphorylation levels of PKA, ERK1/2, CaMKII, and CREB in the hippocampus.	1,2,3,4-tetrahydroisoquinoline-7-sulfonamide	47-50	cAMP responsive element binding protein 1	Mus musculus	122-126
29920752-9	2018	In addition, treatment with pilocarpine significantly suppressed ATRA-induced phosphorylation of cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB).	Pilocarpine	28-39	cAMP responsive element binding protein 1	Mus musculus	169-173
29920752-9	2018	In addition, treatment with pilocarpine significantly suppressed ATRA-induced phosphorylation of cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB).	Tretinoin	65-69	cAMP responsive element binding protein 1	Mus musculus	169-173
29920752-9	2018	In addition, treatment with pilocarpine significantly suppressed ATRA-induced phosphorylation of cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB).	Cyclic AMP	97-127	cAMP responsive element binding protein 1	Mus musculus	169-173
29920752-9	2018	In addition, treatment with pilocarpine significantly suppressed ATRA-induced phosphorylation of cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB).	Cyclic AMP	129-133	cAMP responsive element binding protein 1	Mus musculus	169-173
29920752-10	2018	These findings suggest that the stimulation of m2 - or m4 -AchR suppresses ATRA-induced differentiation of mouse iPS cells into NPCs by inhibiting the cAMP/protein kinase A pathway and CREB activation.	Tretinoin	75-79	cAMP responsive element binding protein 1	Mus musculus	185-189
30298999-7	2018	Protein abundances of cAMP response element binding protein 1(CREB1) and brain-derived neurotrophic factor (BDNF) were evaluated by western blotting.	Cyclic AMP	22-26	cAMP responsive element binding protein 1	Mus musculus	62-67
30395885-0	2018	Adiponectin confers neuroprotection against cerebral ischemia-reperfusion injury through activating the cAMP/PKA-CREB-BDNF signaling.	Cyclic AMP	104-108	cAMP responsive element binding protein 1	Mus musculus	113-117
29719882-9	2018	Neurite outgrowth activity of the glycosides MS and AS was found to involve the activation of sustained ERK phosphorylation leading to CREB activation, while ERK activation was not associated with MA- and AA-induced neurite outgrowth.	Glycosides	34-44	cAMP responsive element binding protein 1	Mus musculus	135-139
30369882-0	2018	Genistein Ameliorates Scopolamine-Induced Amnesia in Mice Through the Regulation of the Cholinergic Neurotransmission, Antioxidant System and the ERK/CREB/BDNF Signaling.	Genistein	0-9	cAMP responsive element binding protein 1	Mus musculus	150-154
30369882-0	2018	Genistein Ameliorates Scopolamine-Induced Amnesia in Mice Through the Regulation of the Cholinergic Neurotransmission, Antioxidant System and the ERK/CREB/BDNF Signaling.	Scopolamine	22-33	cAMP responsive element binding protein 1	Mus musculus	150-154
30395885-11	2018	In conclusion, our findings further suggest that APN exerts protective effect against cerebral I/R injury might through the cAMP/PKA-CREB-BDNF signaling pathway.	Cyclic AMP	124-128	cAMP responsive element binding protein 1	Mus musculus	133-137
30109356-10	2018	RESULTS: The inhibition of pro-inflammatory cytokines by quetiapine was found through the ERK and AKT phosphorylation and subsequent NF-kappaB and CREB signaling pathways.	Quetiapine Fumarate	57-67	cAMP responsive element binding protein 1	Mus musculus	147-151
29722134-0	2018	A novel PDE9 inhibitor WYQ-C36D ameliorates corticosterone-induced neurotoxicity and depression-like behaviors by cGMP-CREB-related signaling.	wyq-c36d	23-31	cAMP responsive element binding protein 1	Mus musculus	119-123
29722134-0	2018	A novel PDE9 inhibitor WYQ-C36D ameliorates corticosterone-induced neurotoxicity and depression-like behaviors by cGMP-CREB-related signaling.	Corticosterone	44-58	cAMP responsive element binding protein 1	Mus musculus	119-123
29722134-0	2018	A novel PDE9 inhibitor WYQ-C36D ameliorates corticosterone-induced neurotoxicity and depression-like behaviors by cGMP-CREB-related signaling.	Cyclic GMP	114-118	cAMP responsive element binding protein 1	Mus musculus	119-123
29722134-6	2018	RESULTS: C36D significantly protected HT-22 cells against corticosterone-induced cytotoxicity and rescued corticosterone-induced decreases in cGMP, CREB phosphorylation, and BDNF expression.	Corticosterone	106-120	cAMP responsive element binding protein 1	Mus musculus	148-152
29637572-3	2018	Here, we identified CREB/ATF bZIP transcription factor (CREBZF) of the activating transcription factor/cAMP response element-binding protein (ATF/CREB) gene family as a key regulator for lipogenesis through insulin-Akt signaling.	Cyclic AMP	103-107	cAMP responsive element binding protein 1	Mus musculus	20-24
29637572-3	2018	Here, we identified CREB/ATF bZIP transcription factor (CREBZF) of the activating transcription factor/cAMP response element-binding protein (ATF/CREB) gene family as a key regulator for lipogenesis through insulin-Akt signaling.	Cyclic AMP	103-107	cAMP responsive element binding protein 1	Mus musculus	56-60
30099679-5	2018	Furthermore, the expression levels of hippocampal protein kinase A-cAMP response element-binding protein (PKA-CREB) and p38-mitogen-activated protein kinases (MAPK) also showed sex difference in the AD mice, with a significant increase in the levels of p-PKA/p-CREB and a decrease in the p-p38 in female, but not male, 3xTg-AD mice.	Cyclic AMP	67-71	cAMP responsive element binding protein 1	Mus musculus	110-114
29710396-8	2018	Based on these results, we conclude that copper chelators regulate the balance between amyloidogenic and nonamyloidogenic processing of AbetaPP via promoting ADAM10 expression through MT1/2 /CREB-dependent signaling pathways.	Copper	41-47	cAMP responsive element binding protein 1	Mus musculus	191-195
30175684-0	2018	The Phosphorylation of CREB at Serine 133 Is a Key Event for Circadian Clock Timing and Entrainment in the Suprachiasmatic Nucleus.	Serine	31-37	cAMP responsive element binding protein 1	Mus musculus	23-27
30175684-2	2018	One event driving CRE-mediated transcription is the phosphorylation of CREB at serine 133 (Ser133).	Serine	79-85	cAMP responsive element binding protein 1	Mus musculus	71-75
30175684-3	2018	Indeed, numerous reporter gene assays have shown that an alanine point mutation in Ser133 reduces CREB-mediated transcription.	Alanine	57-64	cAMP responsive element binding protein 1	Mus musculus	98-102
29710396-0	2018	Copper chelators promote nonamyloidogenic processing of AbetaPP via MT1/2 /CREB-dependent signaling pathways in AbetaPP/PS1 transgenic mice.	Copper	0-6	cAMP responsive element binding protein 1	Mus musculus	75-79
29710396-3	2018	Here, we reported that copper chelators promoted nonamyloidogenic processing of AbetaPP through MT1/2 /CREB-dependent signaling pathways.	Copper	23-29	cAMP responsive element binding protein 1	Mus musculus	103-107
29728920-0	2018	L-3-n-Butylphthalide Regulates Proliferation, Migration, and Differentiation of Neural Stem Cell In Vitro and Promotes Neurogenesis in APP/PS1 Mouse Model by Regulating BDNF/TrkB/CREB/Akt Pathway.	l-3-n-butylphthalide	0-20	cAMP responsive element binding protein 1	Mus musculus	179-183
29728920-7	2018	In addition, L-NBP significantly increased the expressions of BDNF and NGF, tyrosine phosphorylation of its cognate receptor, and phosphorylation of Akt as well as CREB at Ser133 in the hippocampus of APP/PS1 mice.	l-nbp	13-18	cAMP responsive element binding protein 1	Mus musculus	164-168
30099299-9	2018	In addition, DGC induced the downregulation of MITF (melanocyte-specific transcription factor) through suppression of cAMP-CREB pathway.	Cyclic AMP	118-122	cAMP responsive element binding protein 1	Mus musculus	123-127
30111074-3	2018	Furthermore, LJ treatment increased scopolamine-suppressed BDNF expression and CREB phosphorylation in the hippocampi of the brain, as well as suppressed TNF-alpha expression and NF-kappaB activation.	Scopolamine	36-47	cAMP responsive element binding protein 1	Mus musculus	79-83
29935237-8	2018	In diet-induced obese mice, subsequent 7,8-DHF consumption triggered the AMPK/CREB/PGC-1alpha pathways to increase the muscular mitochondrial content.	6,7-dihydroxyflavone	39-46	cAMP responsive element binding protein 1	Mus musculus	78-82
30294251-0	2018	Selective Depletion of CREB in Serotonergic Neurons Affects the Upregulation of Brain-Derived Neurotrophic Factor Evoked by Chronic Fluoxetine Treatment.	Fluoxetine	132-142	cAMP responsive element binding protein 1	Mus musculus	23-27
30215650-8	2018	Furthermore, bacosides encapsulated in the polymersomes (10% loading) showed significant memory loss reversal in chemically induced amnesic mice, supported by the gene expression profiles of Arc, BDNF and CREB as well as by histopathology.	bacosides	13-22	cAMP responsive element binding protein 1	Mus musculus	205-209
30294251-4	2018	In our previous study using mice lacking CREB in serotonergic neurons (Creb1TPH2CreERT2 mice), we showed that selective CREB ablation in these particular neuronal populations is crucial for drug-resistant phenotypes in the tail suspension test observed after fluoxetine administration in Creb1TPH2CreERT2 mice.	Fluoxetine	259-269	cAMP responsive element binding protein 1	Mus musculus	41-45
30227624-6	2018	Moreover, sinomenine inhibited the expressions of p-NMDAR1/NMDAR1, p-CAMKII/CAMKII, and p-CREB/CREB in the hippocampusof morphine-dependent mice and SH-SY5Y cells.	sinomenine	10-20	cAMP responsive element binding protein 1	Mus musculus	90-94
30294251-4	2018	In our previous study using mice lacking CREB in serotonergic neurons (Creb1TPH2CreERT2 mice), we showed that selective CREB ablation in these particular neuronal populations is crucial for drug-resistant phenotypes in the tail suspension test observed after fluoxetine administration in Creb1TPH2CreERT2 mice.	Fluoxetine	259-269	cAMP responsive element binding protein 1	Mus musculus	120-124
30294251-6	2018	Here, we show for the first time that BDNF upregulation observed after fluoxetine in the hippocampus or PFC might be dependent on the transcription factor CREB residing, not within these particular structures targeted by serotonergic projections, but exclusively in serotonergic neurons.	Fluoxetine	71-81	cAMP responsive element binding protein 1	Mus musculus	155-159
29172439-2	2018	The influx of calcium through N-methyl-d-aspartate receptors (NMDARs) is a well-defined mechanism that leads to the increased expression of CREB-dependent genes, including brain derived neurotrophic factor (BDNF), microRNA-132, and activity-regulated cytoskeleton-associated protein (Arc).	Calcium	14-21	cAMP responsive element binding protein 1	Mus musculus	140-144
29932631-6	2018	Most notably, tianeptinaline, a class I HDAC-selective analogue of tianeptine, but not tianeptine itself, increased histone acetylation, and enhanced CREB-mediated transcription and the expression of Arc (activity-regulated cytoskeleton-associated protein).	Tianeptinaline	14-28	cAMP responsive element binding protein 1	Mus musculus	150-154
30227624-6	2018	Moreover, sinomenine inhibited the expressions of p-NMDAR1/NMDAR1, p-CAMKII/CAMKII, and p-CREB/CREB in the hippocampusof morphine-dependent mice and SH-SY5Y cells.	sinomenine	10-20	cAMP responsive element binding protein 1	Mus musculus	95-99
30227624-6	2018	Moreover, sinomenine inhibited the expressions of p-NMDAR1/NMDAR1, p-CAMKII/CAMKII, and p-CREB/CREB in the hippocampusof morphine-dependent mice and SH-SY5Y cells.	Morphine	121-129	cAMP responsive element binding protein 1	Mus musculus	90-94
30227624-6	2018	Moreover, sinomenine inhibited the expressions of p-NMDAR1/NMDAR1, p-CAMKII/CAMKII, and p-CREB/CREB in the hippocampusof morphine-dependent mice and SH-SY5Y cells.	Morphine	121-129	cAMP responsive element binding protein 1	Mus musculus	95-99
30118751-8	2018	Immunoblot analyses revealed that autophosphorylation of Ca2+/calmodulin-dependent protein kinase (CaMK) IIalpha at threonine 286 and phosphorylation of cyclic-adenosine-monophosphate response-element-binding protein (CREB) at serine 133 were markedly increased in the BLA of chronic CORT-treated mice after tone stimulation.	Serine	227-233	cAMP responsive element binding protein 1	Mus musculus	153-216
30118751-8	2018	Immunoblot analyses revealed that autophosphorylation of Ca2+/calmodulin-dependent protein kinase (CaMK) IIalpha at threonine 286 and phosphorylation of cyclic-adenosine-monophosphate response-element-binding protein (CREB) at serine 133 were markedly increased in the BLA of chronic CORT-treated mice after tone stimulation.	Corticosterone	284-288	cAMP responsive element binding protein 1	Mus musculus	153-216
30201979-8	2018	Additionally, we show that repulsive interaction between pS133-CREB and pS422-p300G422S may contribute to the reduced CREB binding to p300G422S.	ps422	72-77	cAMP responsive element binding protein 1	Mus musculus	63-67
30201979-8	2018	Additionally, we show that repulsive interaction between pS133-CREB and pS422-p300G422S may contribute to the reduced CREB binding to p300G422S.	ps422	72-77	cAMP responsive element binding protein 1	Mus musculus	118-122
30201979-8	2018	Additionally, we show that repulsive interaction between pS133-CREB and pS422-p300G422S may contribute to the reduced CREB binding to p300G422S.	p300g422s	78-87	cAMP responsive element binding protein 1	Mus musculus	118-122
32002961-9	2018	In addition, DGC induced the downregulation of MITF (melanocyte-specific transcription factor) through suppression of cAMP-CREB pathway.	Cyclic AMP	118-122	cAMP responsive element binding protein 1	Mus musculus	123-127
30031818-9	2018	Finally, 7,8,4"-THIF significantly increased the expression levels of the following molecules in the hippocampus: brain-derived neurotrophic factor (BDNF); phospho extracellular signal-regulated kinase (ERK); phospho cAMP response element binding (CREB); and choline acetyltransferase (ChAT).	7,8,4"-thif	9-20	cAMP responsive element binding protein 1	Mus musculus	248-252
30031818-10	2018	Our data suggest that 7,8,4"-THIF, a metabolized product of daidzein, improves cognitive function by activating the cholinergic system and the BDNF/ERK/CREB signaling pathway in mice.	7,8,4"-thif	22-33	cAMP responsive element binding protein 1	Mus musculus	152-156
30031818-10	2018	Our data suggest that 7,8,4"-THIF, a metabolized product of daidzein, improves cognitive function by activating the cholinergic system and the BDNF/ERK/CREB signaling pathway in mice.	daidzein	60-68	cAMP responsive element binding protein 1	Mus musculus	152-156
29753754-2	2018	In addition, administration of PEP-1-PEBP1 fusion protein ameliorated H2O2-induced phosphorylation of extracellular signal-regulated kinases (ERK1/2) and facilitated the phosphorylation of cyclic-AMP response element binding protein (CREB) in HT22 cells after exposure to H2O2.	Hydrogen Peroxide	70-74	cAMP responsive element binding protein 1	Mus musculus	189-232
29753754-2	2018	In addition, administration of PEP-1-PEBP1 fusion protein ameliorated H2O2-induced phosphorylation of extracellular signal-regulated kinases (ERK1/2) and facilitated the phosphorylation of cyclic-AMP response element binding protein (CREB) in HT22 cells after exposure to H2O2.	Hydrogen Peroxide	70-74	cAMP responsive element binding protein 1	Mus musculus	234-238
29753754-2	2018	In addition, administration of PEP-1-PEBP1 fusion protein ameliorated H2O2-induced phosphorylation of extracellular signal-regulated kinases (ERK1/2) and facilitated the phosphorylation of cyclic-AMP response element binding protein (CREB) in HT22 cells after exposure to H2O2.	Hydrogen Peroxide	272-276	cAMP responsive element binding protein 1	Mus musculus	189-232
30021350-0	2018	Knockdown of CREB1 promotes apoptosis and decreases estradiol synthesis in mouse granulosa cells.	Estradiol	52-61	cAMP responsive element binding protein 1	Mus musculus	13-18
30021350-5	2018	Results of enzyme linked immunosorbent assay revealed that CREB1 knockdown significantly decreased the concentrations of estradiol (E2) and progesterone (P4) in mGCs.	Estradiol	121-130	cAMP responsive element binding protein 1	Mus musculus	59-64
30021350-5	2018	Results of enzyme linked immunosorbent assay revealed that CREB1 knockdown significantly decreased the concentrations of estradiol (E2) and progesterone (P4) in mGCs.	Progesterone	140-152	cAMP responsive element binding protein 1	Mus musculus	59-64
30021350-7	2018	To elucidate the regulatory mechanism underlying the effects of CREB1 knockdown on steroid synthesis, cell cycle, and apoptosis, we measured the protein expression levels of several related genes in mGCs knocked down CREB1.	Steroids	83-90	cAMP responsive element binding protein 1	Mus musculus	64-69
30021350-11	2018	Taken together, these findings suggested that CREB1 might be a key regulator of mGCs through regulating steroid synthesis, cell proliferation, cell cycle, apoptosis, and other regulators of folliculogenesis.	Steroids	104-111	cAMP responsive element binding protein 1	Mus musculus	46-51
29578035-8	2018	In FTS-treated slices, basal levels of CaMKII, ERK2 and CREB phosphorylation did not differ significantly from those of controls; however, high-frequency stimulation-induced increases in CaMKII, ERK2 and CREB phosphorylation were more significant than in the controls, which were sensitive to PP2 and NMDAr antagonist MK801.	fts	3-6	cAMP responsive element binding protein 1	Mus musculus	56-60
29578035-8	2018	In FTS-treated slices, basal levels of CaMKII, ERK2 and CREB phosphorylation did not differ significantly from those of controls; however, high-frequency stimulation-induced increases in CaMKII, ERK2 and CREB phosphorylation were more significant than in the controls, which were sensitive to PP2 and NMDAr antagonist MK801.	fts	3-6	cAMP responsive element binding protein 1	Mus musculus	204-208
29981334-8	2018	These data indicate that the increased GluN2b expression, and p-ERK and p-CREB levels in the NAc of AAV-shRNA-mTrx-1 mice may be responsible for the METH-primed reinstatement.	Methamphetamine	149-153	cAMP responsive element binding protein 1	Mus musculus	74-78
30166541-0	2018	Alpinetin exerts anti-colitis efficacy by activating AhR, regulating miR-302/DNMT-1/CREB signals, and therefore promoting Treg differentiation.	alpinetin	0-9	cAMP responsive element binding protein 1	Mus musculus	84-88
30200295-5	2018	The expression of the mouse cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB), brain-derived neurotrophic factor (BDNF) and beta-actin mRNAs in hippocampus and frontal cortex was also evaluated, using semiquantitative reverse transcription-polymerase chain reaction.	Cyclic AMP	60-64	cAMP responsive element binding protein 1	Mus musculus	100-104
30166541-9	2018	Finally, CH223191 abolished the amelioration of alpinetin on colitis, induction of Treg cells and regulation of miR-302/DNMT-1/CREB signals in colons of colitis mice.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	9-17	cAMP responsive element binding protein 1	Mus musculus	127-131
29887570-0	2018	Curcumin downregulates 8-br-cAMP-induced steroidogenesis in mouse Leydig cells by suppressing the expression of Cyp11a1 and StAR independently of the PKA-CREB pathway.	Curcumin	0-8	cAMP responsive element binding protein 1	Mus musculus	154-158
29887570-7	2018	Collectively, our data demonstrated that curcumin may suppress cAMP-induced steroidogenesis in mouse Leydig cells by down-regulating Nr5a1/Fos-controlled StAR and Cyp11a1 expression independently of the PKA-CREB signaling pathway.	Curcumin	41-49	cAMP responsive element binding protein 1	Mus musculus	207-211
29885598-7	2018	At molecular level, genistein activated CREB phosphorylation and subsequently induced Bcl-2 expression, and knockdown of CREB diminished the protective effect of genistein on beta-cells induced by lipoglucotoxicity.	Genistein	20-29	cAMP responsive element binding protein 1	Mus musculus	40-44
29680784-5	2018	Furthermore, intracerebroventricular injection of GNF5837, a TrkB antagonist, abrogated antidepressant-like effects of SLB in mice along with the improved NSC proliferation, as well as enhanced levels of p-ERK and p-CREB in mice hippocampus.	GNF-5837	50-57	cAMP responsive element binding protein 1	Mus musculus	216-220
29847860-1	2018	BACKGROUND AND PURPOSE: Inhibition of PDE5 improves synaptic plasticity and memory via enhancing cGMP expression, thus activating the cGMP/cAMP response element binding protein (CREB) signalling pathway.	Cyclic GMP	97-101	cAMP responsive element binding protein 1	Mus musculus	178-182
29847860-1	2018	BACKGROUND AND PURPOSE: Inhibition of PDE5 improves synaptic plasticity and memory via enhancing cGMP expression, thus activating the cGMP/cAMP response element binding protein (CREB) signalling pathway.	Cyclic GMP	134-138	cAMP responsive element binding protein 1	Mus musculus	178-182
29847860-1	2018	BACKGROUND AND PURPOSE: Inhibition of PDE5 improves synaptic plasticity and memory via enhancing cGMP expression, thus activating the cGMP/cAMP response element binding protein (CREB) signalling pathway.	Cyclic AMP	139-143	cAMP responsive element binding protein 1	Mus musculus	178-182
29847860-8	2018	Moreover, KJH-1002 increased cGMP levels in the cortex and the scopolamine-reduced expression of phosphorylated CREB, Levels of ERK 1/2, Akt and brain-derived neurotrophic factor in the cortex and hippocampus were restored by KJH-1002 treatment.	KJH	10-13	cAMP responsive element binding protein 1	Mus musculus	112-116
29847860-8	2018	Moreover, KJH-1002 increased cGMP levels in the cortex and the scopolamine-reduced expression of phosphorylated CREB, Levels of ERK 1/2, Akt and brain-derived neurotrophic factor in the cortex and hippocampus were restored by KJH-1002 treatment.	Scopolamine	63-74	cAMP responsive element binding protein 1	Mus musculus	112-116
29847860-10	2018	CONCLUSION AND IMPLICATIONS: KJH-1002 restored cognitive function in scopolamine-induced amnesia mice by activating the cGMP/CREB signalling pathway and attenuating oxidative stress.	kjh-1002	29-37	cAMP responsive element binding protein 1	Mus musculus	125-129
29966721-5	2018	Bdnf transcription induced by BHBA stimulus was mediated through the cAMP/PKA-triggered phosphorylation of CREB (S133) and the subsequent up-regulation of histone H3 Lysine 27 acetylation (H3K27ac) binding at Bdnf promoters I, II, IV, and VI.	3-Hydroxybutyric Acid	30-34	cAMP responsive element binding protein 1	Mus musculus	107-111
29966721-5	2018	Bdnf transcription induced by BHBA stimulus was mediated through the cAMP/PKA-triggered phosphorylation of CREB (S133) and the subsequent up-regulation of histone H3 Lysine 27 acetylation (H3K27ac) binding at Bdnf promoters I, II, IV, and VI.	Cyclic AMP	69-73	cAMP responsive element binding protein 1	Mus musculus	107-111
29960099-10	2018	These results suggest that Trx-1 ameliorates learning and memory deficits in MPTP-induced PD model in mice via modulating the D1R and the NMDAR-ERK1/2-CREB pathway.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	77-81	cAMP responsive element binding protein 1	Mus musculus	151-155
29524208-6	2018	FFAR2"s downstream cAMP-PKA-CREB pathway was enhanced, leading to overexpression of histone deacetylases (HDACs) in the FFAR2-deficient mice.	Cyclic AMP	19-23	cAMP responsive element binding protein 1	Mus musculus	28-32
30030001-8	2018	In particular, the inhibitory mechanism of 4,5-DCQA on MITF expression was elucidated, revealing that 4,5-DCQA inhibits the phosphorylation of cAMP response element-binding protein (CREB) by attenuating cAMP generation during melanogenesis.	4,5-dicaffeoyl quinic acid	43-51	cAMP responsive element binding protein 1	Mus musculus	143-180
30030001-8	2018	In particular, the inhibitory mechanism of 4,5-DCQA on MITF expression was elucidated, revealing that 4,5-DCQA inhibits the phosphorylation of cAMP response element-binding protein (CREB) by attenuating cAMP generation during melanogenesis.	4,5-dicaffeoyl quinic acid	43-51	cAMP responsive element binding protein 1	Mus musculus	182-186
30030001-8	2018	In particular, the inhibitory mechanism of 4,5-DCQA on MITF expression was elucidated, revealing that 4,5-DCQA inhibits the phosphorylation of cAMP response element-binding protein (CREB) by attenuating cAMP generation during melanogenesis.	4,5-dicaffeoyl quinic acid	102-110	cAMP responsive element binding protein 1	Mus musculus	143-180
30030001-8	2018	In particular, the inhibitory mechanism of 4,5-DCQA on MITF expression was elucidated, revealing that 4,5-DCQA inhibits the phosphorylation of cAMP response element-binding protein (CREB) by attenuating cAMP generation during melanogenesis.	4,5-dicaffeoyl quinic acid	102-110	cAMP responsive element binding protein 1	Mus musculus	182-186
30030001-8	2018	In particular, the inhibitory mechanism of 4,5-DCQA on MITF expression was elucidated, revealing that 4,5-DCQA inhibits the phosphorylation of cAMP response element-binding protein (CREB) by attenuating cAMP generation during melanogenesis.	Cyclic AMP	143-147	cAMP responsive element binding protein 1	Mus musculus	182-186
29803170-6	2018	Reduced intracellular cAMP accumulation by SQA treatment resulted in the suppressed phosphorylation of cAMP-responsive element-binding protein (CREB), leading to the downregulation of microphthalmia-associated transcription factor (MITF) in alpha-MSH-stimulated B16F10 cells.	sargaquinoic acid	43-46	cAMP responsive element binding protein 1	Mus musculus	103-142
29803170-6	2018	Reduced intracellular cAMP accumulation by SQA treatment resulted in the suppressed phosphorylation of cAMP-responsive element-binding protein (CREB), leading to the downregulation of microphthalmia-associated transcription factor (MITF) in alpha-MSH-stimulated B16F10 cells.	sargaquinoic acid	43-46	cAMP responsive element binding protein 1	Mus musculus	144-148
29803170-8	2018	SQA showed high binding affinity to the cAMP binding domain of PKA; the direct binding of SQA to PKA may exert an additional inhibitory effect on the PKA-dependent CREB activation.	sargaquinoic acid	0-3	cAMP responsive element binding protein 1	Mus musculus	164-168
29803170-9	2018	Our data demonstrated that SQA suppressed melanin production through the cAMP/CREB- and ERK1/2-mediated downregulation of MITF in alpha-MSH-stimulated B16F10 cells and SQA has a potential therapeutic agent for the treatment of skin hyperpigmentation disorders.	Melanins	42-49	cAMP responsive element binding protein 1	Mus musculus	78-82
29885598-7	2018	At molecular level, genistein activated CREB phosphorylation and subsequently induced Bcl-2 expression, and knockdown of CREB diminished the protective effect of genistein on beta-cells induced by lipoglucotoxicity.	Genistein	162-171	cAMP responsive element binding protein 1	Mus musculus	121-125
29885598-8	2018	Finally, deletion of GPR30 in beta-cells or islets ablated genistein-induced CREB phosphorylation and its cytoprotective effect.	Genistein	59-68	cAMP responsive element binding protein 1	Mus musculus	77-81
29885598-9	2018	These findings demonstrate that genistein is a survival factor for beta-cells via GPR30-initiated, Galphas-mediated activation of CREB.	galphas	99-106	cAMP responsive element binding protein 1	Mus musculus	130-134
30012602-4	2018	On binding to PPARalpha, aspirin stimulated hippocampal plasticity via transcriptional activation of cAMP response element-binding protein (CREB).	Aspirin	25-32	cAMP responsive element binding protein 1	Mus musculus	101-138
29335844-7	2018	In addition, osmotin increased the expression of the pre- and postsynaptic markers synaptophysin and PSD-95, as well as the activation of the memory-associated markers AMPA receptor and CREB; these effects occurred in an AdipoR1- and NgR1-dependent manner.	osmotin	13-20	cAMP responsive element binding protein 1	Mus musculus	186-190
29948728-0	2018	Neuroprotection of Cytisine Against Cerebral Ischemia-Reperfusion Injury in Mice by Regulating NR2B-ERK/CREB Signal Pathway.	cytisine	19-27	cAMP responsive element binding protein 1	Mus musculus	104-108
30012602-4	2018	On binding to PPARalpha, aspirin stimulated hippocampal plasticity via transcriptional activation of cAMP response element-binding protein (CREB).	Aspirin	25-32	cAMP responsive element binding protein 1	Mus musculus	140-144
30050148-4	2018	High glucose inhibits CREB stimulated KLF15 transcription resulting in downregulation of enzymes in the BCAA catabolism pathway.	Glucose	5-12	cAMP responsive element binding protein 1	Mus musculus	22-26
29616790-4	2018	Moreover, its citrate (3c Cit) possessed improved water solubility and good effects against scopolamine-induced cognitive impairment with inhibition of cortical AChE activities and enhancement of cAMP response element-binding protein (CREB) phosphorylation ex vivo.	Citric Acid	14-21	cAMP responsive element binding protein 1	Mus musculus	196-233
29616790-4	2018	Moreover, its citrate (3c Cit) possessed improved water solubility and good effects against scopolamine-induced cognitive impairment with inhibition of cortical AChE activities and enhancement of cAMP response element-binding protein (CREB) phosphorylation ex vivo.	Citric Acid	14-21	cAMP responsive element binding protein 1	Mus musculus	235-239
29616790-4	2018	Moreover, its citrate (3c Cit) possessed improved water solubility and good effects against scopolamine-induced cognitive impairment with inhibition of cortical AChE activities and enhancement of cAMP response element-binding protein (CREB) phosphorylation ex vivo.	3c cit	23-29	cAMP responsive element binding protein 1	Mus musculus	196-233
29616790-4	2018	Moreover, its citrate (3c Cit) possessed improved water solubility and good effects against scopolamine-induced cognitive impairment with inhibition of cortical AChE activities and enhancement of cAMP response element-binding protein (CREB) phosphorylation ex vivo.	3c cit	23-29	cAMP responsive element binding protein 1	Mus musculus	235-239
29738700-13	2018	Gbetagamma subunit inhibitor treatment increased DMED-induced phosphorylation of CREB, whereas dbcAMP or rolipram had no effect on pCREB induced by DMED.	Dexmedetomidine	49-53	cAMP responsive element binding protein 1	Mus musculus	81-85
30021947-8	2018	On one hand, SIK1 acts so as to block signaling via cAMP Response Element (CRE) Binding Protein (CREB) Regulated Transcriptional Coactivators (CRTCs) and on the other hand, SIK1 acts so as to stimulate signaling via the Myocyte Enhancer Factor 2 (MEF2)/nuclear factor of activated T cell (NFAT) regulated genes.	Cyclic AMP	52-56	cAMP responsive element binding protein 1	Mus musculus	97-101
29749444-7	2018	Propofol, etomidate, ketamine and midazolam inhibited CREB phosphorylation (P&lt;0.05) in a time- and dose-dependent manner.	Propofol	0-8	cAMP responsive element binding protein 1	Mus musculus	54-58
29648983-10	2018	Treatment with CBIO boosted the NR1 and phospho- NR1 subunits of the NMDAR and affected the CREB, phospho-CREB, and brain-derived neurotropic factor (BDNF) pathways.	5-chlorobenzo(d)isoxazol-3-ol	15-19	cAMP responsive element binding protein 1	Mus musculus	92-96
29648983-10	2018	Treatment with CBIO boosted the NR1 and phospho- NR1 subunits of the NMDAR and affected the CREB, phospho-CREB, and brain-derived neurotropic factor (BDNF) pathways.	5-chlorobenzo(d)isoxazol-3-ol	15-19	cAMP responsive element binding protein 1	Mus musculus	106-110
29704309-14	2018	CONCLUSION: These results suggest that the novel PDE2 inhibitor Hcyb1 produced neuroprotective and antidepressant-like effects most likely mediated by cAMP/cGMP-CREB-BDNF signaling.	Cyclic GMP	156-160	cAMP responsive element binding protein 1	Mus musculus	161-165
29019056-5	2018	Further, enrichment analyses of the RNA-sequencing data revealed that in the MPTP-treated mice physical exercise predominantly modulated signaling cascades that are regulated by the top upstream regulators L-DOPA, RICTOR, CREB1, or bicuculline/dalfampridine, associated with movement disorders, mitochondrial dysfunction, and epilepsy-related processes.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	77-81	cAMP responsive element binding protein 1	Mus musculus	222-227
30100984-2	2018	Gene expression of DBP itself is under the control of E-box-dependent binding by the Bmal1-Clock heterodimer and CRE-dependent binding by the cAMP responsive element binding protein (CREB).	Cyclic AMP	142-146	cAMP responsive element binding protein 1	Mus musculus	183-187
30100984-4	2018	In this study, we examined the role of the GPCR (G-protein-coupled receptor)/Galphai3 (Galphai3) controlled cAMP-CREB signaling pathway in the regulation of hepatic expression of core clock and clock-regulated genes, including Dbp.	Cyclic AMP	108-112	cAMP responsive element binding protein 1	Mus musculus	113-117
29261550-14	2018	The phosphor-NR2B, phosphor-CaMKII, and phosphor-CREB also increased in CCI-misaligned mice compared with the CCI-free mice.	CCI	72-75	cAMP responsive element binding protein 1	Mus musculus	49-53
29749444-7	2018	Propofol, etomidate, ketamine and midazolam inhibited CREB phosphorylation (P&lt;0.05) in a time- and dose-dependent manner.	Midazolam	34-43	cAMP responsive element binding protein 1	Mus musculus	54-58
29749444-7	2018	Propofol, etomidate, ketamine and midazolam inhibited CREB phosphorylation (P&lt;0.05) in a time- and dose-dependent manner.	Etomidate	10-19	cAMP responsive element binding protein 1	Mus musculus	54-58
29749444-9	2018	The decrease in CREB phosphorylation revealed additive effects with 100 microM of chelerythrine and 20 microM of PD-98059, and the etomidate-induced decrease in CREB phosphorylation was blocked by 1 mM of NMDA.	chelerythrine	82-95	cAMP responsive element binding protein 1	Mus musculus	16-20
29749444-7	2018	Propofol, etomidate, ketamine and midazolam inhibited CREB phosphorylation (P&lt;0.05) in a time- and dose-dependent manner.	Ketamine	21-29	cAMP responsive element binding protein 1	Mus musculus	54-58
29749444-9	2018	The decrease in CREB phosphorylation revealed additive effects with 100 microM of chelerythrine and 20 microM of PD-98059, and the etomidate-induced decrease in CREB phosphorylation was blocked by 1 mM of NMDA.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	113-121	cAMP responsive element binding protein 1	Mus musculus	16-20
29962949-11	2018	The further study suggested that trans-Resveratrol normalized phosphodiesterases 4A (PDE4A) expression and CREB-BDNF signaling that were disturbed by CACS.	Resveratrol	33-50	cAMP responsive element binding protein 1	Mus musculus	107-111
29749444-9	2018	The decrease in CREB phosphorylation revealed additive effects with 100 microM of chelerythrine and 20 microM of PD-98059, and the etomidate-induced decrease in CREB phosphorylation was blocked by 1 mM of NMDA.	Etomidate	131-140	cAMP responsive element binding protein 1	Mus musculus	16-20
29749444-9	2018	The decrease in CREB phosphorylation revealed additive effects with 100 microM of chelerythrine and 20 microM of PD-98059, and the etomidate-induced decrease in CREB phosphorylation was blocked by 1 mM of NMDA.	Etomidate	131-140	cAMP responsive element binding protein 1	Mus musculus	161-165
29749444-9	2018	The decrease in CREB phosphorylation revealed additive effects with 100 microM of chelerythrine and 20 microM of PD-98059, and the etomidate-induced decrease in CREB phosphorylation was blocked by 1 mM of NMDA.	N-Methylaspartate	205-209	cAMP responsive element binding protein 1	Mus musculus	16-20
29749444-9	2018	The decrease in CREB phosphorylation revealed additive effects with 100 microM of chelerythrine and 20 microM of PD-98059, and the etomidate-induced decrease in CREB phosphorylation was blocked by 1 mM of NMDA.	N-Methylaspartate	205-209	cAMP responsive element binding protein 1	Mus musculus	161-165
29988625-8	2018	Also, using the PKA-specific inhibitor, we found that BHDPC-induced CREB phosphorylation was dependent on PKA, which also contributed to BHDPC-mediated anti-inflammation and neuroprotection.	bhdpc	54-59	cAMP responsive element binding protein 1	Mus musculus	68-72
29688525-7	2018	Proinflammatory cytokines were up-regulated while the expression of BDNF, its high-affinity receptor tropomyosin-related kinase B (TrkB), and the transcription factor (cyclic adenosine monophosphate)-response element-binding protein (CREB) were down-regulated in ambient air mice.	Cyclic AMP	168-198	cAMP responsive element binding protein 1	Mus musculus	234-238
29966363-6	2018	Furthermore, SI (40 mg/kg) treatment markedly upregulated the phosphorylation levels of extracellular signal-regulated kinase (ERK), cAMP response element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) expression levels in the hippocampus.	Isoflavones	13-15	cAMP responsive element binding protein 1	Mus musculus	133-170
29966363-6	2018	Furthermore, SI (40 mg/kg) treatment markedly upregulated the phosphorylation levels of extracellular signal-regulated kinase (ERK), cAMP response element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) expression levels in the hippocampus.	Isoflavones	13-15	cAMP responsive element binding protein 1	Mus musculus	172-176
30046601-11	2018	In addition, GBH mice exhibited increased levels of brain-derived neurotrophic factor (BDNF) and a higher ratio of phosphorylated cAMP response element-binding protein (p-CREB) to CREB (p-CREB/CREB) in the hippocampus.	Cyclic AMP	130-134	cAMP responsive element binding protein 1	Mus musculus	171-175
30046601-12	2018	Our results indicated that GBH can ameliorate depressive-like behaviors, affect the concentration of mood-related hormones, and help to regulate immune/endocrine dysfunction in mice with reserpine-induced depression, likely via activation of the BDNF-CREB pathway.	gbh	27-30	cAMP responsive element binding protein 1	Mus musculus	251-255
30046601-12	2018	Our results indicated that GBH can ameliorate depressive-like behaviors, affect the concentration of mood-related hormones, and help to regulate immune/endocrine dysfunction in mice with reserpine-induced depression, likely via activation of the BDNF-CREB pathway.	Reserpine	187-196	cAMP responsive element binding protein 1	Mus musculus	251-255
29901851-7	2018	Furthermore, alpha-cedrene induced the expression of MOR23 and enhanced its downstream cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA)-cyclic AMP-responsive element-binding protein (CREB) signaling in the skeletal muscle of mice fed chow or high-fat diet.	cedrene	13-26	cAMP responsive element binding protein 1	Mus musculus	195-199
29901851-7	2018	Furthermore, alpha-cedrene induced the expression of MOR23 and enhanced its downstream cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA)-cyclic AMP-responsive element-binding protein (CREB) signaling in the skeletal muscle of mice fed chow or high-fat diet.	Cyclic AMP	87-117	cAMP responsive element binding protein 1	Mus musculus	195-199
29901851-7	2018	Furthermore, alpha-cedrene induced the expression of MOR23 and enhanced its downstream cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA)-cyclic AMP-responsive element-binding protein (CREB) signaling in the skeletal muscle of mice fed chow or high-fat diet.	Cyclic AMP	119-123	cAMP responsive element binding protein 1	Mus musculus	195-199
29901851-7	2018	Furthermore, alpha-cedrene induced the expression of MOR23 and enhanced its downstream cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA)-cyclic AMP-responsive element-binding protein (CREB) signaling in the skeletal muscle of mice fed chow or high-fat diet.	Cyclic AMP	148-158	cAMP responsive element binding protein 1	Mus musculus	195-199
29784793-3	2018	Although cAMP response element-binding protein (CREB) and its coactivators-the cAMP-regulated transcriptional coactivators (CRTCs)-mediate transcriptional effects of cAMP in most tissues, other transcription factors such as ATF2 appear critical for induction of thermogenic genes by cAMP in BAT.	Cyclic AMP	9-13	cAMP responsive element binding protein 1	Mus musculus	48-52
29891820-4	2018	Furthermore, BHCP significantly inhibited melanin content and cellular tyrosinase activity, and downregulated the levels of microphthalmia-associated transcription factor (MITF), phosphorylated levels of cAMP response element-binding (CREB) protein, and tyrosinase in alpha-melanocyte stimulating hormone (alpha-MSH)-induced B16F10 melanoma cells.	bhcp	13-17	cAMP responsive element binding protein 1	Mus musculus	204-233
29891820-4	2018	Furthermore, BHCP significantly inhibited melanin content and cellular tyrosinase activity, and downregulated the levels of microphthalmia-associated transcription factor (MITF), phosphorylated levels of cAMP response element-binding (CREB) protein, and tyrosinase in alpha-melanocyte stimulating hormone (alpha-MSH)-induced B16F10 melanoma cells.	bhcp	13-17	cAMP responsive element binding protein 1	Mus musculus	235-239
29784793-3	2018	Although cAMP response element-binding protein (CREB) and its coactivators-the cAMP-regulated transcriptional coactivators (CRTCs)-mediate transcriptional effects of cAMP in most tissues, other transcription factors such as ATF2 appear critical for induction of thermogenic genes by cAMP in BAT.	Cyclic AMP	79-83	cAMP responsive element binding protein 1	Mus musculus	9-46
29784793-3	2018	Although cAMP response element-binding protein (CREB) and its coactivators-the cAMP-regulated transcriptional coactivators (CRTCs)-mediate transcriptional effects of cAMP in most tissues, other transcription factors such as ATF2 appear critical for induction of thermogenic genes by cAMP in BAT.	Cyclic AMP	79-83	cAMP responsive element binding protein 1	Mus musculus	48-52
29784793-3	2018	Although cAMP response element-binding protein (CREB) and its coactivators-the cAMP-regulated transcriptional coactivators (CRTCs)-mediate transcriptional effects of cAMP in most tissues, other transcription factors such as ATF2 appear critical for induction of thermogenic genes by cAMP in BAT.	Cyclic AMP	79-83	cAMP responsive element binding protein 1	Mus musculus	9-46
29784793-3	2018	Although cAMP response element-binding protein (CREB) and its coactivators-the cAMP-regulated transcriptional coactivators (CRTCs)-mediate transcriptional effects of cAMP in most tissues, other transcription factors such as ATF2 appear critical for induction of thermogenic genes by cAMP in BAT.	Cyclic AMP	79-83	cAMP responsive element binding protein 1	Mus musculus	48-52
29463842-4	2018	Importantly, we demonstrate that pigmentation induced in cultured melanocytic cells and in mice by activation of cAMP/CREB1 pathway depends in large part on FOXQ1.	Cyclic AMP	113-117	cAMP responsive element binding protein 1	Mus musculus	118-123
29188424-7	2018	Furthermore, we delineated that RNS60 increased the transcription of Pgc1a via type IA phosphatidylinositol (PI) 3-kinase-mediated activation of cAMP-response element-binding protein (CREB).	Phosphatidylinositols	87-107	cAMP responsive element binding protein 1	Mus musculus	145-182
29626566-12	2018	These findings demonstrated that J147 has antidepressant-like effects that are mediated, at least in part, by activating the 5-HT1A/cAMP/PKA/CREB/BDNF-signaling pathway.	j147	33-37	cAMP responsive element binding protein 1	Mus musculus	141-145
29626566-12	2018	These findings demonstrated that J147 has antidepressant-like effects that are mediated, at least in part, by activating the 5-HT1A/cAMP/PKA/CREB/BDNF-signaling pathway.	Cyclic AMP	132-136	cAMP responsive element binding protein 1	Mus musculus	141-145
29188424-7	2018	Furthermore, we delineated that RNS60 increased the transcription of Pgc1a via type IA phosphatidylinositol (PI) 3-kinase-mediated activation of cAMP-response element-binding protein (CREB).	Phosphatidylinositols	87-107	cAMP responsive element binding protein 1	Mus musculus	184-188
29775418-7	2018	The prolonged cAMP elevation transcriptionally repressed RRAS in endothelial cells via a cAMP response element-binding protein (CREB) 3-dependent mechanism and significantly disrupted the adherens junction.	Cyclic AMP	14-18	cAMP responsive element binding protein 1	Mus musculus	89-126
29775418-7	2018	The prolonged cAMP elevation transcriptionally repressed RRAS in endothelial cells via a cAMP response element-binding protein (CREB) 3-dependent mechanism and significantly disrupted the adherens junction.	Cyclic AMP	14-18	cAMP responsive element binding protein 1	Mus musculus	128-132
29867482-0	2018	Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3.	linderane	0-9	cAMP responsive element binding protein 1	Mus musculus	72-76
29768201-4	2018	Photoactivation of optoEphB2 during fear conditioning led to activation of the cAMP/Ca2+ responsive element binding (CREB) protein.	Cyclic AMP	79-83	cAMP responsive element binding protein 1	Mus musculus	117-121
29740000-5	2018	SE-EE dose-dependently attenuated LPS-induced inflammation in BV-2 cells, significantly repressed behavioural/cognitive impairment, dose-dependently regulated the cholinergic function, suppressed oxidative stress markers, regulated inflammatory cytokines/associated proteins expression and effectively ameliorated p-CREB/BDNF levels, neurogenesis (DCX stain), neuron proliferation (Ki67 stain) in scopolamine-administered mice.	se-ee	0-5	cAMP responsive element binding protein 1	Mus musculus	316-320
29742127-0	2018	Amelioration of Huntington"s disease phenotypes by Beta-Lapachone is associated with increases in Sirt1 expression, CREB phosphorylation and PGC-1alpha deacetylation.	beta-lapachone	51-65	cAMP responsive element binding protein 1	Mus musculus	116-120
29510125-0	2018	6,7,4"-Trihydroxyisoflavone, a major metabolite of daidzein, improves learning and memory via the cholinergic system and the p-CREB/BDNF signaling pathway in mice.	daidzein	51-59	cAMP responsive element binding protein 1	Mus musculus	127-131
29867712-10	2018	These genes can activate the calcium (Ca2+)-CaMKII-cAMP-response element-binding protein (CREB) pathway.	Calcium	29-36	cAMP responsive element binding protein 1	Mus musculus	90-94
29867712-10	2018	These genes can activate the calcium (Ca2+)-CaMKII-cAMP-response element-binding protein (CREB) pathway.	Cyclic AMP	51-55	cAMP responsive element binding protein 1	Mus musculus	90-94
29510125-0	2018	6,7,4"-Trihydroxyisoflavone, a major metabolite of daidzein, improves learning and memory via the cholinergic system and the p-CREB/BDNF signaling pathway in mice.	6,7,4'-trihydroxyisoflavone	0-27	cAMP responsive element binding protein 1	Mus musculus	127-131
29510125-9	2018	In addition, immunohistochemistry and Western blot results revealed that 6,7,4"-THIF significantly increased brain-derived neurotrophic factor (BDNF) and phosphor cAMP response element binding (CREB) in the hippocampus of mice.	6,7,4"-thif	73-84	cAMP responsive element binding protein 1	Mus musculus	163-192
29510125-9	2018	In addition, immunohistochemistry and Western blot results revealed that 6,7,4"-THIF significantly increased brain-derived neurotrophic factor (BDNF) and phosphor cAMP response element binding (CREB) in the hippocampus of mice.	6,7,4"-thif	73-84	cAMP responsive element binding protein 1	Mus musculus	194-198
29510125-10	2018	Taken together, these findings suggest that 6,7,4"-THIF improves cognitive dysfunction induced by scopolamine and enhances learning and memory by activation of the cholinergic system and the p-CREB/BDNF signaling pathway in mice.	6,7,4"-thif	44-55	cAMP responsive element binding protein 1	Mus musculus	193-197
28578486-11	2018	CONCLUSIONS: KH032 attenuated cognitive defificits in the Abeta1-42-infused mice by increasing BDNF expression and ERK1/2 and CREB phosphorylation and inhibiting neuronal loss and neuroinflflammatory response, suggesting that KH032 has therapeutic potential in neurodegenerative disorders such as AD.	kh032	13-18	cAMP responsive element binding protein 1	Mus musculus	126-130
30134805-2	2018	The aim of the present study was to explore the effects involved with cyclic adenosine monophosphate (cAMP) response element-binding (CREB)1 gene silencing on cognitive dysfunction through meditation of the protein kinase A (PKA)-CREB signaling pathway in mice with VD.	Cyclic AMP	70-100	cAMP responsive element binding protein 1	Mus musculus	134-138
30134805-2	2018	The aim of the present study was to explore the effects involved with cyclic adenosine monophosphate (cAMP) response element-binding (CREB)1 gene silencing on cognitive dysfunction through meditation of the protein kinase A (PKA)-CREB signaling pathway in mice with VD.	Cyclic AMP	70-100	cAMP responsive element binding protein 1	Mus musculus	230-234
30134805-2	2018	The aim of the present study was to explore the effects involved with cyclic adenosine monophosphate (cAMP) response element-binding (CREB)1 gene silencing on cognitive dysfunction through meditation of the protein kinase A (PKA)-CREB signaling pathway in mice with VD.	Cyclic AMP	102-106	cAMP responsive element binding protein 1	Mus musculus	134-138
30134805-2	2018	The aim of the present study was to explore the effects involved with cyclic adenosine monophosphate (cAMP) response element-binding (CREB)1 gene silencing on cognitive dysfunction through meditation of the protein kinase A (PKA)-CREB signaling pathway in mice with VD.	Cyclic AMP	102-106	cAMP responsive element binding protein 1	Mus musculus	230-234
28578486-10	2018	Finally, KH032 treatment increased phosphorylation of ERK1/2 and CREB, vital for ERK-CREB signaling.	kh032	9-14	cAMP responsive element binding protein 1	Mus musculus	65-69
29390063-4	2018	Protein levels of proinflammatory cytokines, brain-derived neurotrophic factor (BDNF), and extracellular signal-regulated kinase (ERK1/2)-cAMP-response element-binding protein (CREB) signaling pathway after activation or inhibition of D3R in the brain of depressive mice were also investigated.	Cyclic AMP	138-142	cAMP responsive element binding protein 1	Mus musculus	177-181
28578486-10	2018	Finally, KH032 treatment increased phosphorylation of ERK1/2 and CREB, vital for ERK-CREB signaling.	kh032	9-14	cAMP responsive element binding protein 1	Mus musculus	85-89
29853881-4	2018	In our previous study, TSHR was identified in the liver; the major role of TSHR in cholesterol metabolism was illustrated, as TSH could regulate hepatic cholesterol metabolism via cAMP/PKA/CREB/HMGCR and SREBP2/HNF4alpha/CYP7A1 pathways.	Cholesterol	83-94	cAMP responsive element binding protein 1	Mus musculus	189-193
29853881-4	2018	In our previous study, TSHR was identified in the liver; the major role of TSHR in cholesterol metabolism was illustrated, as TSH could regulate hepatic cholesterol metabolism via cAMP/PKA/CREB/HMGCR and SREBP2/HNF4alpha/CYP7A1 pathways.	Thyrotropin	23-26	cAMP responsive element binding protein 1	Mus musculus	189-193
29390063-6	2018	Pretreatment with pramipexole (PPX), a preferential D3R agonist, showed antidepressant effects on LPS-induced depression-like behavior through preventing changes in LPS-induced proinflammatory cytokines (tumour necrosis factor-alpha, interleukin-1beta, and interleukin-6), BDNF, and ERK1/2-CREB signaling pathway in the VTA and NAc.	Pramipexole	18-29	cAMP responsive element binding protein 1	Mus musculus	290-294
29390063-6	2018	Pretreatment with pramipexole (PPX), a preferential D3R agonist, showed antidepressant effects on LPS-induced depression-like behavior through preventing changes in LPS-induced proinflammatory cytokines (tumour necrosis factor-alpha, interleukin-1beta, and interleukin-6), BDNF, and ERK1/2-CREB signaling pathway in the VTA and NAc.	Pramipexole	31-34	cAMP responsive element binding protein 1	Mus musculus	290-294
29390063-7	2018	In opposition, treatment with a D3R selective antagonist NGB 2904 alone made mice susceptible to depression-like effects and caused changes in accordance with the LPS-induced alterations in proinflammatory cytokines, BDNF, and the ERK1/2-CREB signaling pathway in the mPFC and NAc.	4-Nitrophenyl 6-O-Beta-D-Glucopyranosyl-Beta-D-Glucopyranoside	57-60	cAMP responsive element binding protein 1	Mus musculus	238-242
29740317-6	2018	Additionally, the protein expressions of phosphorylated Akt, ERK1/2, and CREB in the hippocampus were significantly decreased by scopolamine, but these decreases were reversed by MSE treatment.	Scopolamine	129-140	cAMP responsive element binding protein 1	Mus musculus	73-77
29017935-1	2018	In the spermatogenic cell line GC-2, dehydroepiandrosterone sulfate (DHEAS), activates the Src/Ras/c-Raf/Erk1/2/CREB(ATF-1) signaling cascade.	Dehydroepiandrosterone Sulfate	37-67	cAMP responsive element binding protein 1	Mus musculus	112-116
29017935-1	2018	In the spermatogenic cell line GC-2, dehydroepiandrosterone sulfate (DHEAS), activates the Src/Ras/c-Raf/Erk1/2/CREB(ATF-1) signaling cascade.	Dehydroepiandrosterone Sulfate	69-74	cAMP responsive element binding protein 1	Mus musculus	112-116
29017935-3	2018	In the Sertoli cell line TM4, DHEAS-induces activation of Erk1/2, CREB, and ATF-1, stimulates expression of claudin-3 and claudin-5 and augments transepithelial resistance, indicating the formation of tight junctions between adjacent Sertoli cells.	Dehydroepiandrosterone Sulfate	30-35	cAMP responsive element binding protein 1	Mus musculus	66-70
28547530-6	2018	Likewise, phosphorylation of GluA1 (Ser-831) and CREB (Ser-133), respective downstream targets of CaMKII and CaMKIV, also significantly decreased in the CA1 region.	Serine	55-58	cAMP responsive element binding protein 1	Mus musculus	49-53
29257864-0	2018	Rapamycin Confers Neuroprotection against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis through the Activation of Autophagy and mTOR/Akt/CREB Signaling Pathways.	Sirolimus	0-9	cAMP responsive element binding protein 1	Mus musculus	166-170
29257864-7	2018	Moreover, rapamycin pretreatment protected against colistin-induced mitochondrial dysfunction, caspase activation, and subsequent apoptosis by up-regulating autophagy and activating the Akt/CREB, NGF, and Nrf2 pathways, while inhibiting p53 signaling.	Sirolimus	10-19	cAMP responsive element binding protein 1	Mus musculus	190-194
29621230-3	2018	We show that L441R ZIP14 is no longer trafficked towards the plasma membrane and excessively accumulates intracellular zinc, resulting in hyper-activation of cAMP-CREB and NFAT signaling.	Cyclic AMP	158-162	cAMP responsive element binding protein 1	Mus musculus	163-167
29581378-7	2018	Furthermore, we provide evidence that changes in the ratio of NMDA subunits GluN2A/GluN2B can also be detected in the synapse and mitochondria, which contributes to a persistent activation of the prosurvival ERK-CREB pathway and its downstream target genes.	N-Methylaspartate	62-66	cAMP responsive element binding protein 1	Mus musculus	212-216
29506687-9	2018	Furthermore, p38 MAP kinase (p38 MAPK)/cyclic adenosine monophosphate response element-binding protein (CREB) pathway activation by ethanol increased AGT and Ang II in cardiomyocytes.	Cyclic AMP	39-69	cAMP responsive element binding protein 1	Mus musculus	104-108
29506687-9	2018	Furthermore, p38 MAP kinase (p38 MAPK)/cyclic adenosine monophosphate response element-binding protein (CREB) pathway activation by ethanol increased AGT and Ang II in cardiomyocytes.	Ethanol	132-139	cAMP responsive element binding protein 1	Mus musculus	104-108
29288827-9	2018	Further, WGE increased the protein expression of BDNF and promoted the hippocampal protein phosphorylation ratio of cAMP response element binding protein (CREB) and protein kinase B (Akt).	Cyclic AMP	116-120	cAMP responsive element binding protein 1	Mus musculus	155-159
29334651-6	2018	Contrarily, methyl CpG binding protein 2 (MeCP2) were dramatically reduced in 50 and 100 mg/L NaF groups, while cAMP-response element binding protein (CREB) mRNA level was significantly decreased in all fluoride groups.	Fluorides	203-211	cAMP responsive element binding protein 1	Mus musculus	112-149
29334651-6	2018	Contrarily, methyl CpG binding protein 2 (MeCP2) were dramatically reduced in 50 and 100 mg/L NaF groups, while cAMP-response element binding protein (CREB) mRNA level was significantly decreased in all fluoride groups.	Fluorides	203-211	cAMP responsive element binding protein 1	Mus musculus	151-155
28502041-3	2018	Our findings showed that the glucose administration increased phosphorylated Akt, phosphorylated CREB, exon 1- and exon 4-specific BDNF transcripts, and FGF1 transcripts that are associated with the epigenetic changes expected to open the chromatin and a reduction in histone deacetylase 2 (HDAC2) in neurons and astrocytes of the murine hippocampus.	Glucose	29-36	cAMP responsive element binding protein 1	Mus musculus	97-101
29570621-1	2018	The activation of cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) via phosphorylation in the hippocampus is an important signaling mechanism for enhancing memory processing.	Cyclic AMP	18-48	cAMP responsive element binding protein 1	Mus musculus	90-94
29353067-0	2018	Antinociception of the spirocyclopiperazinium salt compound LXM-15 via activating alpha7 nAChR and M4 mAChR and inhibiting CaMKIIalpha/cAMP/CREB/CGRP signalling pathway in mice.	spirocyclopiperazinium salt	23-50	cAMP responsive element binding protein 1	Mus musculus	140-144
29353067-0	2018	Antinociception of the spirocyclopiperazinium salt compound LXM-15 via activating alpha7 nAChR and M4 mAChR and inhibiting CaMKIIalpha/cAMP/CREB/CGRP signalling pathway in mice.	LXM-15	60-66	cAMP responsive element binding protein 1	Mus musculus	140-144
29353067-3	2018	Western blot analysis showed that LXM-15 significantly reduced the upregulation of phosphorylation of calcium/calmodulin -dependent protein kinase IIalpha (CaMKIIalpha) and cAMP response element-binding protein (CREB), and further decreased the elevation of calcitonin gene related peptide (CGRP) in the dorsal root ganglion (DRG) and spinal cord in mice.	LXM-15	34-40	cAMP responsive element binding protein 1	Mus musculus	173-210
29353067-3	2018	Western blot analysis showed that LXM-15 significantly reduced the upregulation of phosphorylation of calcium/calmodulin -dependent protein kinase IIalpha (CaMKIIalpha) and cAMP response element-binding protein (CREB), and further decreased the elevation of calcitonin gene related peptide (CGRP) in the dorsal root ganglion (DRG) and spinal cord in mice.	LXM-15	34-40	cAMP responsive element binding protein 1	Mus musculus	212-216
29353067-6	2018	This study first reported that intragastric administration of LXM-15 produced significant analgesic effect, which may be related to the activation of alpha7 nicotinic acetylcholine receptor and M4 muscarine acetylcholine receptor, and thereby inhibiting CaMKIIalpha/cAMP/CREB/CGRP signalling pathway.	LXM-15	62-68	cAMP responsive element binding protein 1	Mus musculus	271-275
29570621-7	2018	In conclusion, melatonin mediated the MT1-ERK-p90RSK-CREB-BDNF signaling pathway in the in vitro long-term memory processing model and increased the levels of p-CREB and BDNF expression in melatonin-treated cells compared to untreated HT-22 cells in the cellular aged state.	Melatonin	15-24	cAMP responsive element binding protein 1	Mus musculus	53-57
29570621-1	2018	The activation of cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) via phosphorylation in the hippocampus is an important signaling mechanism for enhancing memory processing.	Cyclic AMP	50-54	cAMP responsive element binding protein 1	Mus musculus	90-94
29570621-7	2018	In conclusion, melatonin mediated the MT1-ERK-p90RSK-CREB-BDNF signaling pathway in the in vitro long-term memory processing model and increased the levels of p-CREB and BDNF expression in melatonin-treated cells compared to untreated HT-22 cells in the cellular aged state.	Melatonin	15-24	cAMP responsive element binding protein 1	Mus musculus	161-165
29570621-2	2018	Although melatonin is known to increase CREB expression in various animal models, the signaling mechanism between melatonin and CREB has been unknown in vitro.	Melatonin	9-18	cAMP responsive element binding protein 1	Mus musculus	40-44
29570621-7	2018	In conclusion, melatonin mediated the MT1-ERK-p90RSK-CREB-BDNF signaling pathway in the in vitro long-term memory processing model and increased the levels of p-CREB and BDNF expression in melatonin-treated cells compared to untreated HT-22 cells in the cellular aged state.	Melatonin	189-198	cAMP responsive element binding protein 1	Mus musculus	161-165
29570621-8	2018	Therefore, this paper suggests that melatonin induces CREB signaling pathways associated with long-term memory processing in vitro.	Melatonin	36-45	cAMP responsive element binding protein 1	Mus musculus	54-58
29570621-2	2018	Although melatonin is known to increase CREB expression in various animal models, the signaling mechanism between melatonin and CREB has been unknown in vitro.	Melatonin	114-123	cAMP responsive element binding protein 1	Mus musculus	128-132
29570621-3	2018	Thus, we confirmed the signaling pathway between the melatonin receptor 1 (MT1) and CREB using melatonin in HT-22 cells.	Melatonin	53-62	cAMP responsive element binding protein 1	Mus musculus	84-88
29570621-4	2018	Melatonin increased MT1 and gradually induced signals associated with long-term memory processing through phosphorylation of Raf, ERK, p90RSK, CREB, and BDNF expression.	Melatonin	0-9	cAMP responsive element binding protein 1	Mus musculus	143-147
29570621-6	2018	Furthermore, we investigated whether melatonin regulated the expressions of CREB-BDNF associated with long-term memory processing in aged HT-22 cells.	Melatonin	37-46	cAMP responsive element binding protein 1	Mus musculus	76-80
29707685-1	2018	Cyclic AMP-response element binding protein zhangfei (CREBZF), a member of ATF/CREB (activating transcription factor/ cAMP response element binding protein) family, regulates numerous cellular functions and development of cells by interacting transcription factors.	Cyclic AMP	118-122	cAMP responsive element binding protein 1	Mus musculus	54-58
29615891-7	2018	In addition, we confirmed that the extracellular signal-related kinase/cAMP-response element binding protein (ERK/CREB) signaling pathways were responsible for the up-regulation of ADAM10 in catalpol-treated SweAPP N2a cells.	Cyclic AMP	71-75	cAMP responsive element binding protein 1	Mus musculus	114-118
29500411-7	2018	Silencing CREB also abrogated JWA-increased GLT-1 expression and glutamate uptake.	Glutamic Acid	65-74	cAMP responsive element binding protein 1	Mus musculus	10-14
29241138-5	2018	In addition, high fluoride exposure also reduced the mRNA and protein levels of cAMP response element-binding protein (CREB), brain-derived neurotrophic factor (BDNF), and neural cell adhesion molecule (NCAM).	Fluorides	18-26	cAMP responsive element binding protein 1	Mus musculus	80-117
29241138-5	2018	In addition, high fluoride exposure also reduced the mRNA and protein levels of cAMP response element-binding protein (CREB), brain-derived neurotrophic factor (BDNF), and neural cell adhesion molecule (NCAM).	Fluorides	18-26	cAMP responsive element binding protein 1	Mus musculus	119-123
29538343-8	2018	Isoproterenol increased PNLIP expression in a cAMP/protein kinase A/ cyclic AMP response element binding protein (CREB)-dependent manner.	Isoproterenol	0-13	cAMP responsive element binding protein 1	Mus musculus	69-112
29538343-8	2018	Isoproterenol increased PNLIP expression in a cAMP/protein kinase A/ cyclic AMP response element binding protein (CREB)-dependent manner.	Isoproterenol	0-13	cAMP responsive element binding protein 1	Mus musculus	114-118
29458098-11	2018	Spermine increased phospho-CREB content and phospho-CREB/total CREB ratio in the cerebral cortex of LPS-treated mice.	Spermine	0-8	cAMP responsive element binding protein 1	Mus musculus	27-31
29118086-5	2018	We found that the reduced CREB/CRTC2 activity impaired the cAMP-dependent increase in GLP-1 secretion, whereas expression of constitutively active CRTC2 increased GLP-1 exocytosis from the L cells.	Cyclic AMP	59-63	cAMP responsive element binding protein 1	Mus musculus	26-30
29414647-0	2018	Methamphetamine modulates the production of interleukin-6 and tumor necrosis factor-alpha via the cAMP/PKA/CREB signaling pathway in lipopolysaccharide-activated microglia.	Methamphetamine	0-15	cAMP responsive element binding protein 1	Mus musculus	107-111
29414647-0	2018	Methamphetamine modulates the production of interleukin-6 and tumor necrosis factor-alpha via the cAMP/PKA/CREB signaling pathway in lipopolysaccharide-activated microglia.	Cyclic AMP	98-102	cAMP responsive element binding protein 1	Mus musculus	107-111
29414647-11	2018	Both the concentration of cAMP and the phosphorylation of CREB were increased by METH in LPS-activated microglial cells.	Methamphetamine	81-85	cAMP responsive element binding protein 1	Mus musculus	58-62
29414647-14	2018	These results suggest that the differential regulation of IL-6 and TNF-alpha by METH in LPS-activated microglial cells may be attributable to the cAMP/PKA/CREB signaling pathway.	Methamphetamine	80-84	cAMP responsive element binding protein 1	Mus musculus	155-159
29414647-14	2018	These results suggest that the differential regulation of IL-6 and TNF-alpha by METH in LPS-activated microglial cells may be attributable to the cAMP/PKA/CREB signaling pathway.	Cyclic AMP	146-150	cAMP responsive element binding protein 1	Mus musculus	155-159
28321769-11	2018	We found that PACA induced the phosphorylation of Akt, ERK, and CREB against MPTP-mediated alterations.	N-propargyl caffeate amide	14-18	cAMP responsive element binding protein 1	Mus musculus	64-68
28321769-11	2018	We found that PACA induced the phosphorylation of Akt, ERK, and CREB against MPTP-mediated alterations.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	77-81	cAMP responsive element binding protein 1	Mus musculus	64-68
28321769-15	2018	Collectively, our results suggest that PACA may rescue NGF insufficiency via sequential activation of PI3K/Akt, ERK1/2, and CREB signaling pathways.	N-propargyl caffeate amide	39-43	cAMP responsive element binding protein 1	Mus musculus	124-128
29126931-6	2018	In addition, allylguaiacol inhibited H2O2-induced damage of HT22 with increasing production of brain-derived neurotrophic factor (BDNF), phosphorylation of phosphoinositide 3-kinase (PI3K), and cyclic AMP response element-binding protein (CREB).	Eugenol	13-26	cAMP responsive element binding protein 1	Mus musculus	194-237
29126931-6	2018	In addition, allylguaiacol inhibited H2O2-induced damage of HT22 with increasing production of brain-derived neurotrophic factor (BDNF), phosphorylation of phosphoinositide 3-kinase (PI3K), and cyclic AMP response element-binding protein (CREB).	Eugenol	13-26	cAMP responsive element binding protein 1	Mus musculus	239-243
29458098-11	2018	Spermine increased phospho-CREB content and phospho-CREB/total CREB ratio in the cerebral cortex of LPS-treated mice.	Spermine	0-8	cAMP responsive element binding protein 1	Mus musculus	52-56
29126931-6	2018	In addition, allylguaiacol inhibited H2O2-induced damage of HT22 with increasing production of brain-derived neurotrophic factor (BDNF), phosphorylation of phosphoinositide 3-kinase (PI3K), and cyclic AMP response element-binding protein (CREB).	Hydrogen Peroxide	37-41	cAMP responsive element binding protein 1	Mus musculus	194-237
29458098-11	2018	Spermine increased phospho-CREB content and phospho-CREB/total CREB ratio in the cerebral cortex of LPS-treated mice.	Spermine	0-8	cAMP responsive element binding protein 1	Mus musculus	52-56
29126931-6	2018	In addition, allylguaiacol inhibited H2O2-induced damage of HT22 with increasing production of brain-derived neurotrophic factor (BDNF), phosphorylation of phosphoinositide 3-kinase (PI3K), and cyclic AMP response element-binding protein (CREB).	Hydrogen Peroxide	37-41	cAMP responsive element binding protein 1	Mus musculus	239-243
29458098-12	2018	The results support that the protective effect of spermine on LPS-induced memory deficits depends on TrkB receptor activation and is accompanied by restoration of mature BDNF levels in hippocampus and cerebral cortex, as well as increased CREB phosphorylation in the cerebral cortex.	Spermine	50-58	cAMP responsive element binding protein 1	Mus musculus	239-243
29458418-7	2018	RESULTS: Targeting the cyclic adenosine monophosphate (cAMP)/cAMP-response element binding protein (CREB) pathway, S14 rescued cognitive decline by improving hippocampal neurogenesis in APP/PS1 transgenic mice.	Cyclic AMP	61-65	cAMP responsive element binding protein 1	Mus musculus	100-104
29670659-9	2018	Gagam-Palmultang has beneficial effects against scopolamine-induced memory impairments, which are exerted via modulation of the cholinergic system as well as the PI3K and ERK/CREB/BDNF signaling pathway.	Scopolamine	48-59	cAMP responsive element binding protein 1	Mus musculus	175-179
29515368-8	2018	The inhibition of caspase-3 activity prior to ethanol administration prevented ethanol-induced loss of MeCP2, CREB activation, epigenetic regulation of Arc expression, long-term potentiation (LTP), spatial memory deficits and activity-dependent impairment of several signaling molecules, including MeCP2, in adult mice.	Ethanol	79-86	cAMP responsive element binding protein 1	Mus musculus	110-114
29434807-8	2018	Sevoflurane inhibited the phosphorylation of ERK1/2 and CREB, stimulated the phosphorylation of p38 and NF-kappaB, but did not significantly affect the phosphorylation of JNK.	Sevoflurane	0-11	cAMP responsive element binding protein 1	Mus musculus	56-60
29174741-0	2018	Antidepressant-like effect of zileuton is accompanied by hippocampal neuroinflammation reduction and CREB/BDNF upregulation in lipopolysaccharide-challenged mice.	zileuton	30-38	cAMP responsive element binding protein 1	Mus musculus	101-105
29174741-7	2018	CONCLUSIONS: Zileuton abrogates LPS-induced depressive-like behaviors and neuroinflammation, and enhances CREB/BDNF signaling in the hippocampus, suggesting that zileuton could have potential therapeutic value for depression.	zileuton	162-170	cAMP responsive element binding protein 1	Mus musculus	106-110
29143164-0	2018	Upregulation of Myelin Gene Expression by a Physically-Modified Saline via Phosphatidylinositol 3-Kinase-Mediated Activation of CREB: Implications for Multiple Sclerosis.	Sodium Chloride	64-70	cAMP responsive element binding protein 1	Mus musculus	128-132
29274780-5	2018	Furthermore, FSH bound to the FSH receptor promoted CREB phosphorylation, which was activated by cAMP-PKA.	Cyclic AMP	97-101	cAMP responsive element binding protein 1	Mus musculus	52-56
29770155-6	2018	The administration of GIN elevated the protein expression of BDNF, which was mediated via the activation of protein kinase B/Akt- and cAMP-response element binding protein (CREB) signaling pathway.	gingerol	22-25	cAMP responsive element binding protein 1	Mus musculus	134-171
29770155-6	2018	The administration of GIN elevated the protein expression of BDNF, which was mediated via the activation of protein kinase B/Akt- and cAMP-response element binding protein (CREB) signaling pathway.	gingerol	22-25	cAMP responsive element binding protein 1	Mus musculus	173-177
29370115-0	2018	Ethanol Extract of Oldenlandia diffusa Herba Attenuates Scopolamine-Induced Cognitive Impairments in Mice via Activation of BDNF, P-CREB and Inhibition of Acetylcholinesterase.	Ethanol	0-7	cAMP responsive element binding protein 1	Mus musculus	132-136
29370115-0	2018	Ethanol Extract of Oldenlandia diffusa Herba Attenuates Scopolamine-Induced Cognitive Impairments in Mice via Activation of BDNF, P-CREB and Inhibition of Acetylcholinesterase.	Scopolamine	56-67	cAMP responsive element binding protein 1	Mus musculus	132-136
29370115-7	2018	The protein expression of brain-derived neurotrophic factor (BDNF) and phospho-cAMP response element-binding protein (p-CREB) (Ser133) was increased in ODH pretreated group compared to control group.	Cyclic AMP	79-83	cAMP responsive element binding protein 1	Mus musculus	120-124
28782589-9	2018	These results suggest that overexpression of Trx-1 may occlude the CPP induced by METH through regulating the activity of CREB and the expression of DeltaFosB.	Methamphetamine	82-86	cAMP responsive element binding protein 1	Mus musculus	122-126
29274780-7	2018	Overall, this study shows that FSH induces fat deposition and promotes the transformation of cholesterol to estrogen through CREB activation by cAMP-PKA in mouse adipose tissue.	Cholesterol	93-104	cAMP responsive element binding protein 1	Mus musculus	125-129
29274780-7	2018	Overall, this study shows that FSH induces fat deposition and promotes the transformation of cholesterol to estrogen through CREB activation by cAMP-PKA in mouse adipose tissue.	Cyclic AMP	144-148	cAMP responsive element binding protein 1	Mus musculus	125-129
29127035-8	2018	Finally, inhibition of cAMP responsive element binding protein (CREB), a PPARgamma coactivator, partially mitigated pyraclostrobin-induced TG accumulation, suggesting TG accumulation is occurring through a CREB-driven mechanism.	pyrachlostrobin	116-130	cAMP responsive element binding protein 1	Mus musculus	23-62
29127035-8	2018	Finally, inhibition of cAMP responsive element binding protein (CREB), a PPARgamma coactivator, partially mitigated pyraclostrobin-induced TG accumulation, suggesting TG accumulation is occurring through a CREB-driven mechanism.	pyrachlostrobin	116-130	cAMP responsive element binding protein 1	Mus musculus	64-68
29127035-8	2018	Finally, inhibition of cAMP responsive element binding protein (CREB), a PPARgamma coactivator, partially mitigated pyraclostrobin-induced TG accumulation, suggesting TG accumulation is occurring through a CREB-driven mechanism.	pyrachlostrobin	116-130	cAMP responsive element binding protein 1	Mus musculus	206-210
29127035-8	2018	Finally, inhibition of cAMP responsive element binding protein (CREB), a PPARgamma coactivator, partially mitigated pyraclostrobin-induced TG accumulation, suggesting TG accumulation is occurring through a CREB-driven mechanism.	Triglycerides	139-141	cAMP responsive element binding protein 1	Mus musculus	23-62
29127035-8	2018	Finally, inhibition of cAMP responsive element binding protein (CREB), a PPARgamma coactivator, partially mitigated pyraclostrobin-induced TG accumulation, suggesting TG accumulation is occurring through a CREB-driven mechanism.	Triglycerides	139-141	cAMP responsive element binding protein 1	Mus musculus	64-68
29127035-8	2018	Finally, inhibition of cAMP responsive element binding protein (CREB), a PPARgamma coactivator, partially mitigated pyraclostrobin-induced TG accumulation, suggesting TG accumulation is occurring through a CREB-driven mechanism.	Triglycerides	167-169	cAMP responsive element binding protein 1	Mus musculus	23-62
29127035-8	2018	Finally, inhibition of cAMP responsive element binding protein (CREB), a PPARgamma coactivator, partially mitigated pyraclostrobin-induced TG accumulation, suggesting TG accumulation is occurring through a CREB-driven mechanism.	Triglycerides	167-169	cAMP responsive element binding protein 1	Mus musculus	64-68
30346862-0	2018	Aminoguanidine reverses cognitive deficits and activation of cAMP/CREB/BDNF pathway in mouse hippocampus after traumatic brain injury (TBI).	pimagedine	0-14	cAMP responsive element binding protein 1	Mus musculus	66-70
29107072-2	2018	We characterized the expression of phosphorylated Creb (p-Creb), a target and mediator of cAMP signaling, in developing and cystic kidney models.	Cyclic AMP	90-94	cAMP responsive element binding protein 1	Mus musculus	50-54
29107072-2	2018	We characterized the expression of phosphorylated Creb (p-Creb), a target and mediator of cAMP signaling, in developing and cystic kidney models.	Cyclic AMP	90-94	cAMP responsive element binding protein 1	Mus musculus	58-62
29107072-8	2018	8-Br-cAMP addition to wild-type embryonic kidney explants induced proximal tubular cystogenesis and p-Creb expression; these effects were blocked by co-addition of protein kinase A inhibitor.	8-Bromo Cyclic Adenosine Monophosphate	0-9	cAMP responsive element binding protein 1	Mus musculus	102-106
29107072-9	2018	Thus p-Creb/cAMP signaling is appropriate in NP and early nephron derivatives, but disappears in mature proximal tubules.	Cyclic AMP	12-16	cAMP responsive element binding protein 1	Mus musculus	7-11
30346862-0	2018	Aminoguanidine reverses cognitive deficits and activation of cAMP/CREB/BDNF pathway in mouse hippocampus after traumatic brain injury (TBI).	Cyclic AMP	61-65	cAMP responsive element binding protein 1	Mus musculus	66-70
30346862-7	2018	CONCLUSIONS: We suspect that AG (200 and 400 mg/kg) might reverse TBI-induced selective loss of postsynaptic proteins and learning and memory deficits with the activation of cAMP/CREB/BDNF signalling pathway.	Cyclic AMP	174-178	cAMP responsive element binding protein 1	Mus musculus	179-183
29277915-0	2018	Diethylstilbestrol regulates mouse gubernaculum testis cell proliferation via PLC-Ca2+ -CREB pathway.	Diethylstilbestrol	0-18	cAMP responsive element binding protein 1	Mus musculus	88-92
29277915-5	2018	Mechanistically, we found that U-73122 inhibited DES-induced activation of cAMP-response element binding protein (CREB) in gubernaculum testis cells.	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	31-38	cAMP responsive element binding protein 1	Mus musculus	75-112
29277915-5	2018	Mechanistically, we found that U-73122 inhibited DES-induced activation of cAMP-response element binding protein (CREB) in gubernaculum testis cells.	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	31-38	cAMP responsive element binding protein 1	Mus musculus	114-118
29277915-6	2018	In conclusion, these data suggest that the effects of DES on mouse gubernaculum testis cells are mediated by PLC-Ca2+ -CREB pathway.	Diethylstilbestrol	54-57	cAMP responsive element binding protein 1	Mus musculus	119-123
29277915-9	2018	Our findings provide the first evidence that PLC-Ca2+ -CREB signalling pathway mediates the nongenomic effects of diethylstilbestrol on gubernaculum testis cells.	Diethylstilbestrol	114-132	cAMP responsive element binding protein 1	Mus musculus	55-59
28993972-5	2018	We estimated the effect of acute (IMO 1x) and repeated (IMO 7x) restraint stressors lasting 30 and 120 min on the expression of mRNA CREB, CRH-R1, and CRH-R2 by qPCR.	imo 1x	34-40	cAMP responsive element binding protein 1	Mus musculus	133-137
28993972-5	2018	We estimated the effect of acute (IMO 1x) and repeated (IMO 7x) restraint stressors lasting 30 and 120 min on the expression of mRNA CREB, CRH-R1, and CRH-R2 by qPCR.	imo 7x	56-62	cAMP responsive element binding protein 1	Mus musculus	133-137
29940597-0	2018	Farnesoid X Receptor (FXR) Interacts with Camp Response Element Binding Protein (CREB) to Modulate Glucagon-Like Peptide-1 (7-36) Amide (GLP-1) Secretion by Intestinal L Cell.	Amides	130-135	cAMP responsive element binding protein 1	Mus musculus	42-79
29175324-7	2018	The results showed that lixisenatide could reduce amyloid plaques, neurofibrillary tangles and neuroinflammation in the hippocampi of 12-month-old APP/PS1/tau female mice; activation of PKA-CREB signaling pathway and inhibition of p38-MAPK might be the important mechanisms in the neuroprotective function of lixisenatide.	lixisenatide	24-36	cAMP responsive element binding protein 1	Mus musculus	190-194
29590648-6	2018	CREB1 antagonist KG-501 was used to block CREB signal.	naphthol AS-E phosphate	17-23	cAMP responsive element binding protein 1	Mus musculus	0-5
29590648-6	2018	CREB1 antagonist KG-501 was used to block CREB signal.	naphthol AS-E phosphate	17-23	cAMP responsive element binding protein 1	Mus musculus	0-4
29732971-11	2018	We have seen that cAMP response element is present in the promoter of socs3 gene, that cinnamic acid induces the activation of CREB, that siRNA knockdown of CREB abrogates cinnamic acid-mediated upregulation of SOCS3, and that cinnamic acid treatment leads to the recruitment of CREB to the socs3 gene.	Cyclic AMP	18-22	cAMP responsive element binding protein 1	Mus musculus	157-161
29732971-11	2018	We have seen that cAMP response element is present in the promoter of socs3 gene, that cinnamic acid induces the activation of CREB, that siRNA knockdown of CREB abrogates cinnamic acid-mediated upregulation of SOCS3, and that cinnamic acid treatment leads to the recruitment of CREB to the socs3 gene.	Cyclic AMP	18-22	cAMP responsive element binding protein 1	Mus musculus	157-161
29732971-11	2018	We have seen that cAMP response element is present in the promoter of socs3 gene, that cinnamic acid induces the activation of CREB, that siRNA knockdown of CREB abrogates cinnamic acid-mediated upregulation of SOCS3, and that cinnamic acid treatment leads to the recruitment of CREB to the socs3 gene.	cinnamic acid	87-100	cAMP responsive element binding protein 1	Mus musculus	127-131
29732971-11	2018	We have seen that cAMP response element is present in the promoter of socs3 gene, that cinnamic acid induces the activation of CREB, that siRNA knockdown of CREB abrogates cinnamic acid-mediated upregulation of SOCS3, and that cinnamic acid treatment leads to the recruitment of CREB to the socs3 gene.	cinnamic acid	172-185	cAMP responsive element binding protein 1	Mus musculus	127-131
29732971-11	2018	We have seen that cAMP response element is present in the promoter of socs3 gene, that cinnamic acid induces the activation of CREB, that siRNA knockdown of CREB abrogates cinnamic acid-mediated upregulation of SOCS3, and that cinnamic acid treatment leads to the recruitment of CREB to the socs3 gene.	cinnamic acid	172-185	cAMP responsive element binding protein 1	Mus musculus	157-161
29732971-11	2018	We have seen that cAMP response element is present in the promoter of socs3 gene, that cinnamic acid induces the activation of CREB, that siRNA knockdown of CREB abrogates cinnamic acid-mediated upregulation of SOCS3, and that cinnamic acid treatment leads to the recruitment of CREB to the socs3 gene.	cinnamic acid	172-185	cAMP responsive element binding protein 1	Mus musculus	157-161
29732971-11	2018	We have seen that cAMP response element is present in the promoter of socs3 gene, that cinnamic acid induces the activation of CREB, that siRNA knockdown of CREB abrogates cinnamic acid-mediated upregulation of SOCS3, and that cinnamic acid treatment leads to the recruitment of CREB to the socs3 gene.	cinnamic acid	172-185	cAMP responsive element binding protein 1	Mus musculus	127-131
29732971-11	2018	We have seen that cAMP response element is present in the promoter of socs3 gene, that cinnamic acid induces the activation of CREB, that siRNA knockdown of CREB abrogates cinnamic acid-mediated upregulation of SOCS3, and that cinnamic acid treatment leads to the recruitment of CREB to the socs3 gene.	cinnamic acid	172-185	cAMP responsive element binding protein 1	Mus musculus	157-161
29732971-11	2018	We have seen that cAMP response element is present in the promoter of socs3 gene, that cinnamic acid induces the activation of CREB, that siRNA knockdown of CREB abrogates cinnamic acid-mediated upregulation of SOCS3, and that cinnamic acid treatment leads to the recruitment of CREB to the socs3 gene.	cinnamic acid	172-185	cAMP responsive element binding protein 1	Mus musculus	157-161
29732971-12	2018	CONCLUSIONS: These studies suggest that cinnamic acid upregulates the expression of SOCS3 in glial cells via CREB pathway, which may be of importance in neuroinflammatory and neurodegenerative disorders.	cinnamic acid	40-53	cAMP responsive element binding protein 1	Mus musculus	109-113
29940597-0	2018	Farnesoid X Receptor (FXR) Interacts with Camp Response Element Binding Protein (CREB) to Modulate Glucagon-Like Peptide-1 (7-36) Amide (GLP-1) Secretion by Intestinal L Cell.	Amides	130-135	cAMP responsive element binding protein 1	Mus musculus	81-85
29940597-11	2018	CONCLUSION: In the present study, we demonstrated a negative regulation of GLP-1 secretion by FXR in L cell lines, GLUTag and STC-1; FXR exerts its function in L cells through interacting with CREB, a crucial transcriptional regulator of cAMP-CREB signaling pathway, to inhibit its transcriptional activity.	Cyclic AMP	238-242	cAMP responsive element binding protein 1	Mus musculus	193-197
28857442-3	2018	Here, we show that Yes-associated protein (YAP) is a direct target induced by CREB upon retinoic acid (RA)-induced neurite outgrowth stimuli in N2a cells.	Tretinoin	88-101	cAMP responsive element binding protein 1	Mus musculus	78-82
30282353-5	2018	Inhibition of microglia activation by minocycline or CREB phosphorylation by H89, an inhibitor of protein kinase A (PKA), abolished Abeta-induced microglia CREB hyperphosphorylation with restoration of neuronal function and attenuation of inflammatory response, i.e., reduced levels of interleukin-6 (IL6) and pCREB binding of matrix metalloproteinase-9 (MMP9) DNA.	Minocycline	38-49	cAMP responsive element binding protein 1	Mus musculus	156-160
28857442-3	2018	Here, we show that Yes-associated protein (YAP) is a direct target induced by CREB upon retinoic acid (RA)-induced neurite outgrowth stimuli in N2a cells.	Tretinoin	103-105	cAMP responsive element binding protein 1	Mus musculus	78-82
29302213-7	2018	In addition, cilostazol pretreatment increased cAMP response element-binding protein (CREB) phosphorylation and decreased neuroinflammation.	Cilostazol	13-23	cAMP responsive element binding protein 1	Mus musculus	47-84
29302213-7	2018	In addition, cilostazol pretreatment increased cAMP response element-binding protein (CREB) phosphorylation and decreased neuroinflammation.	Cilostazol	13-23	cAMP responsive element binding protein 1	Mus musculus	86-90
29435104-0	2018	Niclosamide suppresses acute myeloid leukemia cell proliferation through inhibition of CREB-dependent signaling pathways.	Niclosamide	0-11	cAMP responsive element binding protein 1	Mus musculus	87-91
29058041-9	2018	DHM activated the ERK1/2-CREB pathway and increased glycogen synthase kinase-3 beta (GSK-3beta) phosphorylation at ser-9, with upregulation of BDNF expression, in both hippocampal tissues and cultured hippocampal cells.	dihydromyricetin	0-3	cAMP responsive element binding protein 1	Mus musculus	25-29
29435104-4	2018	Niclosamide significantly inhibited CREB function and CREB-mediated gene expression in cells, leading to apoptosis and G1/S cell cycle arrest with reduced phosphorylated CREB levels.	Niclosamide	0-11	cAMP responsive element binding protein 1	Mus musculus	36-40
29435104-4	2018	Niclosamide significantly inhibited CREB function and CREB-mediated gene expression in cells, leading to apoptosis and G1/S cell cycle arrest with reduced phosphorylated CREB levels.	Niclosamide	0-11	cAMP responsive element binding protein 1	Mus musculus	54-58
29435104-4	2018	Niclosamide significantly inhibited CREB function and CREB-mediated gene expression in cells, leading to apoptosis and G1/S cell cycle arrest with reduced phosphorylated CREB levels.	Niclosamide	0-11	cAMP responsive element binding protein 1	Mus musculus	54-58
29435104-5	2018	CREB knockdown protected cells from niclosamide treatment-mediated cytotoxic effects.	Niclosamide	36-47	cAMP responsive element binding protein 1	Mus musculus	0-4
29435104-6	2018	Furthermore, treatment with a combination of niclosamide and CREB inhibitor XX-650-23 showed an additive anti-proliferative effect, consistent with the hypothesis that niclosamide and XX-650-23 regulate the same targets or pathways to inhibit proliferation and survival of AML cells.	Niclosamide	168-179	cAMP responsive element binding protein 1	Mus musculus	61-65
29435104-10	2018	Therefore, our results demonstrate niclosamide as a potential drug to treat AML by inducing apoptosis and cell cycle arrest through inhibition of CREB-dependent pathways in AML cells.	Niclosamide	35-46	cAMP responsive element binding protein 1	Mus musculus	146-150
28857544-1	2017	Initial work in Drosophila and mice demonstrated that the transcription factor cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) is a master control gene for memory formation.	Cyclic AMP	79-109	cAMP responsive element binding protein 1	Mus musculus	151-155
28857544-1	2017	Initial work in Drosophila and mice demonstrated that the transcription factor cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) is a master control gene for memory formation.	Cyclic AMP	111-115	cAMP responsive element binding protein 1	Mus musculus	151-155
28993145-6	2017	EABTO decreased the amounts of phosphorylated cAMP response element-binding protein (CREB) and cyclic adenosine monophosphate (cAMP), thereby inhibiting expression of microphthalmia-associated transcription factor (MITF).	eabto	0-5	cAMP responsive element binding protein 1	Mus musculus	46-83
28993145-6	2017	EABTO decreased the amounts of phosphorylated cAMP response element-binding protein (CREB) and cyclic adenosine monophosphate (cAMP), thereby inhibiting expression of microphthalmia-associated transcription factor (MITF).	eabto	0-5	cAMP responsive element binding protein 1	Mus musculus	85-89
28993145-6	2017	EABTO decreased the amounts of phosphorylated cAMP response element-binding protein (CREB) and cyclic adenosine monophosphate (cAMP), thereby inhibiting expression of microphthalmia-associated transcription factor (MITF).	Cyclic AMP	46-50	cAMP responsive element binding protein 1	Mus musculus	85-89
28993145-9	2017	SIGNIFICANCE: EABTO inhibits melanogenesis in B16F1 melanoma cells via suppression of the cAMP-CREB pathway and activation of ERK, thus decreasing expression of MITF and of melanogenic enzymes.	eabto	14-19	cAMP responsive element binding protein 1	Mus musculus	95-99
28993145-9	2017	SIGNIFICANCE: EABTO inhibits melanogenesis in B16F1 melanoma cells via suppression of the cAMP-CREB pathway and activation of ERK, thus decreasing expression of MITF and of melanogenic enzymes.	Cyclic AMP	90-94	cAMP responsive element binding protein 1	Mus musculus	95-99
28943528-1	2017	Scopoletin was recently shown to stimulate melanogenesis through cAMP-response element-binding protein (CREB) phosphorylation.	Scopoletin	0-10	cAMP responsive element binding protein 1	Mus musculus	65-102
29038164-0	2018	Protein Kinase A/CREB Signaling Prevents Adriamycin-Induced Podocyte Apoptosis via Upregulation of Mitochondrial Respiratory Chain Complexes.	Doxorubicin	41-51	cAMP responsive element binding protein 1	Mus musculus	17-21
29038164-3	2018	Here we show that the PKA agonist 8-(4-chlorophenylthio)adenosine 3",5"-cyclic monophosphate-cyclic AMP (pCPT-cAMP) prevented the production of adriamycin (ADR)-induced reactive oxygen species and apoptosis in podocytes, which were inhibited by CREB RNA interference (RNAi).	8-(4-chlorophenylthio)adenosine 3",5"-cyclic monophosphate-cyclic amp	34-103	cAMP responsive element binding protein 1	Mus musculus	245-249
29038164-3	2018	Here we show that the PKA agonist 8-(4-chlorophenylthio)adenosine 3",5"-cyclic monophosphate-cyclic AMP (pCPT-cAMP) prevented the production of adriamycin (ADR)-induced reactive oxygen species and apoptosis in podocytes, which were inhibited by CREB RNA interference (RNAi).	8-Cpt-camp	105-114	cAMP responsive element binding protein 1	Mus musculus	245-249
29038164-3	2018	Here we show that the PKA agonist 8-(4-chlorophenylthio)adenosine 3",5"-cyclic monophosphate-cyclic AMP (pCPT-cAMP) prevented the production of adriamycin (ADR)-induced reactive oxygen species and apoptosis in podocytes, which were inhibited by CREB RNA interference (RNAi).	Doxorubicin	144-154	cAMP responsive element binding protein 1	Mus musculus	245-249
29038164-5	2018	Inhibition of CREB expression alleviated pCPT-cAMP-induced ND3, but not the recovery of ND1/4 protein, in ADR-treated podocytes.	pcpt	41-45	cAMP responsive element binding protein 1	Mus musculus	14-18
29038164-5	2018	Inhibition of CREB expression alleviated pCPT-cAMP-induced ND3, but not the recovery of ND1/4 protein, in ADR-treated podocytes.	Cyclic AMP	46-50	cAMP responsive element binding protein 1	Mus musculus	14-18
29038164-6	2018	In addition, CREB RNAi blocked the pCPT-cAMP-induced increase in ATP and the expression of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC1-alpha).	pcpt	35-39	cAMP responsive element binding protein 1	Mus musculus	13-17
29038164-6	2018	In addition, CREB RNAi blocked the pCPT-cAMP-induced increase in ATP and the expression of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC1-alpha).	Cyclic AMP	40-44	cAMP responsive element binding protein 1	Mus musculus	13-17
29038164-6	2018	In addition, CREB RNAi blocked the pCPT-cAMP-induced increase in ATP and the expression of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC1-alpha).	Adenosine Triphosphate	65-68	cAMP responsive element binding protein 1	Mus musculus	13-17
29197324-1	2017	BACKGROUND: PDE4 cyclic nucleotide phosphodiesterases regulate 3", 5" cAMP abundance in the CNS and thereby regulate PKA activity and phosphorylation of CREB, which has been implicated in learning and memory, depression and other functions.	Cyclic AMP	70-74	cAMP responsive element binding protein 1	Mus musculus	153-157
28943528-1	2017	Scopoletin was recently shown to stimulate melanogenesis through cAMP-response element-binding protein (CREB) phosphorylation.	Scopoletin	0-10	cAMP responsive element binding protein 1	Mus musculus	104-108
29195509-14	2017	Linagliptin group had greater cerebral phospho-Akt (P &lt; 0.05) and phospho-CREB (P &lt; 0.05) than control group.	Linagliptin	0-11	cAMP responsive element binding protein 1	Mus musculus	77-81
28679060-0	2017	Protective effects of a green tea polyphenol, epigallocatechin-3-gallate, against sevoflurane-induced neuronal apoptosis involve regulation of CREB/BDNF/TrkB and PI3K/Akt/mTOR signalling pathways in neonatal mice.	Polyphenols	34-44	cAMP responsive element binding protein 1	Mus musculus	143-147
28679060-0	2017	Protective effects of a green tea polyphenol, epigallocatechin-3-gallate, against sevoflurane-induced neuronal apoptosis involve regulation of CREB/BDNF/TrkB and PI3K/Akt/mTOR signalling pathways in neonatal mice.	epigallocatechin gallate	46-72	cAMP responsive element binding protein 1	Mus musculus	143-147
28679060-0	2017	Protective effects of a green tea polyphenol, epigallocatechin-3-gallate, against sevoflurane-induced neuronal apoptosis involve regulation of CREB/BDNF/TrkB and PI3K/Akt/mTOR signalling pathways in neonatal mice.	Sevoflurane	82-93	cAMP responsive element binding protein 1	Mus musculus	143-147
28679060-8	2017	Sevoflurane-mediated downregulation of cAMP/CREB and BDNF/TrkB signalling was inhibited by EGCG.	Sevoflurane	0-11	cAMP responsive element binding protein 1	Mus musculus	44-48
28679060-8	2017	Sevoflurane-mediated downregulation of cAMP/CREB and BDNF/TrkB signalling was inhibited by EGCG.	Cyclic AMP	39-43	cAMP responsive element binding protein 1	Mus musculus	44-48
28679060-8	2017	Sevoflurane-mediated downregulation of cAMP/CREB and BDNF/TrkB signalling was inhibited by EGCG.	epigallocatechin gallate	91-95	cAMP responsive element binding protein 1	Mus musculus	44-48
28679060-11	2017	The study indicates that EGCG was able to effectively inhibit sevoflurane-induced neurodegeneration and improve learning and memory retention of mice via activation of CREB/BDNF/TrkB-PI3K/Akt signalling.	epigallocatechin gallate	25-29	cAMP responsive element binding protein 1	Mus musculus	168-172
28679060-11	2017	The study indicates that EGCG was able to effectively inhibit sevoflurane-induced neurodegeneration and improve learning and memory retention of mice via activation of CREB/BDNF/TrkB-PI3K/Akt signalling.	Sevoflurane	62-73	cAMP responsive element binding protein 1	Mus musculus	168-172
29228623-1	2017	The cAMP-responsive element binding protein CREB is frequently overexpressed and activated in tumors of distinct histology, leading to enhanced proliferation, migration, invasion and angiogenesis as well as reduced apoptosis.	Cyclic AMP	4-8	cAMP responsive element binding protein 1	Mus musculus	44-48
28899728-10	2017	Furthermore, maslinic acid normalized the phosphorylation levels of Akt-GSK-3beta and ERK-CREB in the prefrontal cortex.	maslinic acid	13-26	cAMP responsive element binding protein 1	Mus musculus	90-94
28899728-11	2017	Overall, maslinic acid ameliorated the schizophrenia-like symptoms induced by MK-801, and these effects may be partly mediated through Akt-GSK-3beta and ERK-CREB activation.	maslinic acid	9-22	cAMP responsive element binding protein 1	Mus musculus	157-161
28899728-11	2017	Overall, maslinic acid ameliorated the schizophrenia-like symptoms induced by MK-801, and these effects may be partly mediated through Akt-GSK-3beta and ERK-CREB activation.	Dizocilpine Maleate	78-84	cAMP responsive element binding protein 1	Mus musculus	157-161
29132537-8	2017	The repression by NFIL3 required its basic leucine zipper DNA binding domain, and it competed with CREB onto the binding of cAMP response element in the gluconeogenic promoters.	Cyclic AMP	124-128	cAMP responsive element binding protein 1	Mus musculus	99-103
29157831-0	2017	Vitis labruscana leaf extract ameliorates scopolamine-induced impairments with activation of Akt, ERK and CREB in mice.	Scopolamine	42-53	cAMP responsive element binding protein 1	Mus musculus	106-110
29157831-11	2017	Consistent with the cell experiment results, LEVL restored scopolamine-decreased phosphorylation of Akt, ERK, and CREB and scopolamine-reduced expression of brain-derived neuroprotective factor expression in mouse hippocampi.	levl	45-49	cAMP responsive element binding protein 1	Mus musculus	114-118
29157831-11	2017	Consistent with the cell experiment results, LEVL restored scopolamine-decreased phosphorylation of Akt, ERK, and CREB and scopolamine-reduced expression of brain-derived neuroprotective factor expression in mouse hippocampi.	Scopolamine	59-70	cAMP responsive element binding protein 1	Mus musculus	114-118
29157831-12	2017	CONCLUSION: Our results suggest that LEVL promotes phosphorylation of Akt, ERK, and CREB in the hippocampus and ameliorates scopolamine-induced memory impairment in mice.	levl	37-41	cAMP responsive element binding protein 1	Mus musculus	84-88
29089199-6	2017	Moreover using a luciferase assay and Western blotting analysis, we verified that the gene of cyclic AMP response element (CRE)-binding protein 1 (Creb1) was a potential target of miR-27a-3p, which in effect hindered the expression of its downstream factor cytochrome P450 family 19 subfamily A polypeptide 1 (Cyp19a1).	Cyclic AMP	94-104	cAMP responsive element binding protein 1	Mus musculus	147-152
28973639-0	2017	1,2-Dichloroethane Induces Reproductive Toxicity Mediated by the CREM/CREB Signaling Pathway in Male NIH Swiss Mice.	ethylene dichloride	0-18	cAMP responsive element binding protein 1	Mus musculus	70-74
28973639-4	2017	Cyclic adenosine monophosphate (cAMP)-response element binding protein (CREB) and cAMP-response element modulator (CREM) were significantly inhibited by 1,2-DCE.	Cyclic AMP	0-30	cAMP responsive element binding protein 1	Mus musculus	72-76
28973639-4	2017	Cyclic adenosine monophosphate (cAMP)-response element binding protein (CREB) and cAMP-response element modulator (CREM) were significantly inhibited by 1,2-DCE.	Cyclic AMP	32-36	cAMP responsive element binding protein 1	Mus musculus	72-76
28973639-4	2017	Cyclic adenosine monophosphate (cAMP)-response element binding protein (CREB) and cAMP-response element modulator (CREM) were significantly inhibited by 1,2-DCE.	ethylene dichloride	153-160	cAMP responsive element binding protein 1	Mus musculus	72-76
28973639-8	2017	These findings suggest that 1,2-DCE inhibits CREM/CREB signaling cascade and subsequently induces apoptosis associated with p53 activation and mitochondrial dysfunction.	ethylene dichloride	28-35	cAMP responsive element binding protein 1	Mus musculus	50-54
29176858-10	2017	Intraperitoneal injection of D-serine obviously limited the lipopolysaccharide-induced changes, including the impairment of learning and memory, the loss of NMDA receptor subunits, robust neuroinflammation, the levels of ROS stress and the decrease of p-CREB in the hippocampus of mice.	D-serine	29-37	cAMP responsive element binding protein 1	Mus musculus	254-258
28985058-1	2017	Phosphodiesterase 5 (PDE5) hydrolyzes cyclic guanosine monophosphate (cGMP) leading to increased levels of the cAMP response element binding protein (CREB), a transcriptional factor involved with learning and memory processes.	Cyclic GMP	38-68	cAMP responsive element binding protein 1	Mus musculus	111-148
28985058-1	2017	Phosphodiesterase 5 (PDE5) hydrolyzes cyclic guanosine monophosphate (cGMP) leading to increased levels of the cAMP response element binding protein (CREB), a transcriptional factor involved with learning and memory processes.	Cyclic GMP	38-68	cAMP responsive element binding protein 1	Mus musculus	150-154
28985058-1	2017	Phosphodiesterase 5 (PDE5) hydrolyzes cyclic guanosine monophosphate (cGMP) leading to increased levels of the cAMP response element binding protein (CREB), a transcriptional factor involved with learning and memory processes.	Cyclic GMP	70-74	cAMP responsive element binding protein 1	Mus musculus	111-148
28985058-1	2017	Phosphodiesterase 5 (PDE5) hydrolyzes cyclic guanosine monophosphate (cGMP) leading to increased levels of the cAMP response element binding protein (CREB), a transcriptional factor involved with learning and memory processes.	Cyclic GMP	70-74	cAMP responsive element binding protein 1	Mus musculus	150-154
27734601-7	2017	Similarly, NGB2904 and SCH23390 showed opposite/differential effects on cocaine-induced structural plasticity, conditioned place preference and locomotor activity and signaling activation, including the activation of ERK, CREB and NR1 and the expression of c-fos and Cdk5.	Cocaine	72-79	cAMP responsive element binding protein 1	Mus musculus	222-226
29228623-5	2017	This was associated with diminished expression levels of the glucose transporter 1, reduced glucose uptake and reduced glycolytic activity in HER-2/neu-transfected cells with down-regulated CREB when compared to HER-2/neu+ cells.	Glucose	61-68	cAMP responsive element binding protein 1	Mus musculus	190-194
29228623-10	2017	CREB promotes the detoxification of ROS by catalase, therefore protecting the mitochondrial activity under oxidative stress.	ros	36-39	cAMP responsive element binding protein 1	Mus musculus	0-4
28721437-0	2017	ERK1 is dispensable for mouse pancreatic beta cell function but is necessary for glucose-induced full activation of MSK1 and CREB.	Glucose	81-88	cAMP responsive element binding protein 1	Mus musculus	125-129
29053621-6	2017	Isoproterenol also promoted cAMP response element-binding protein 1 (CREB1) and activating transcription factor 4 (ATF4) phosphorylation.	Isoproterenol	0-13	cAMP responsive element binding protein 1	Mus musculus	28-67
29053621-6	2017	Isoproterenol also promoted cAMP response element-binding protein 1 (CREB1) and activating transcription factor 4 (ATF4) phosphorylation.	Isoproterenol	0-13	cAMP responsive element binding protein 1	Mus musculus	69-74
29053621-8	2017	Isoproterenol-induced CREB1, ATF4, NFATc1, and RANKL expressions were suppressed by H89.	Isoproterenol	0-13	cAMP responsive element binding protein 1	Mus musculus	22-27
28978809-5	2017	Mechanistically, reduction in the potassium concentration to the lower limit of the physiological range increased intracellular calcium, which activated a cAMP response element-binding protein (CREB) signal that subsequently enhanced autophagy and promoted vascular smooth muscle cell (VSMC) calcification.	Potassium	34-43	cAMP responsive element binding protein 1	Mus musculus	155-192
28978809-5	2017	Mechanistically, reduction in the potassium concentration to the lower limit of the physiological range increased intracellular calcium, which activated a cAMP response element-binding protein (CREB) signal that subsequently enhanced autophagy and promoted vascular smooth muscle cell (VSMC) calcification.	Potassium	34-43	cAMP responsive element binding protein 1	Mus musculus	194-198
28978809-5	2017	Mechanistically, reduction in the potassium concentration to the lower limit of the physiological range increased intracellular calcium, which activated a cAMP response element-binding protein (CREB) signal that subsequently enhanced autophagy and promoted vascular smooth muscle cell (VSMC) calcification.	Calcium	128-135	cAMP responsive element binding protein 1	Mus musculus	155-192
28978809-5	2017	Mechanistically, reduction in the potassium concentration to the lower limit of the physiological range increased intracellular calcium, which activated a cAMP response element-binding protein (CREB) signal that subsequently enhanced autophagy and promoted vascular smooth muscle cell (VSMC) calcification.	Calcium	128-135	cAMP responsive element binding protein 1	Mus musculus	194-198
28978809-6	2017	Inhibition of calcium signals and knockdown of either CREB or ATG7, an autophagy regulator, attenuated VSMC calcification induced by low potassium.	Potassium	137-146	cAMP responsive element binding protein 1	Mus musculus	54-58
28978809-7	2017	Consistently, elevated autophagy and CREB signaling were demonstrated in the calcified arteries from low potassium diet-fed mice as well as aortic arteries exposed to low potassium ex vivo.	Potassium	105-114	cAMP responsive element binding protein 1	Mus musculus	37-41
28978809-7	2017	Consistently, elevated autophagy and CREB signaling were demonstrated in the calcified arteries from low potassium diet-fed mice as well as aortic arteries exposed to low potassium ex vivo.	Potassium	171-180	cAMP responsive element binding protein 1	Mus musculus	37-41
28940173-6	2017	Furthermore, LQ markedly increased the protein level of brain-derived neurotrophic factor (BDNF) and phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP response element binding (CREB) in the hippocampus of scopolamine-induced mice.	Scopolamine	227-238	cAMP responsive element binding protein 1	Mus musculus	168-197
28940173-6	2017	Furthermore, LQ markedly increased the protein level of brain-derived neurotrophic factor (BDNF) and phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP response element binding (CREB) in the hippocampus of scopolamine-induced mice.	Scopolamine	227-238	cAMP responsive element binding protein 1	Mus musculus	199-203
28940173-7	2017	Taken together, our results indicate that LQ may be useful for the treatment of learning and memory impairments, and that the beneficial effects of LQ are mediated, in part, by cholinergic and BDNF/ERK/CREB signaling enhancement and/or protection.	liquiritigenin	148-150	cAMP responsive element binding protein 1	Mus musculus	202-206
28721437-10	2017	By contrast, ERK1 was required for glucose-induced full activation of several targets involved in beta cell survival; MSK1 and CREB were less active in Erk1 -/- mouse beta cells (p &lt; 0.01) compared with Erk1 +/+ mouse beta cells, and their phosphorylation could only be restored when ERK1 was re-expressed and not when ERK2 was overexpressed.	Glucose	35-42	cAMP responsive element binding protein 1	Mus musculus	127-131
28817076-10	2017	Therefore, our data suggest that SM70EE may prevent TMT neurotoxicity through promoting activation of BDNF/CREB neuroprotective signaling pathways in neuronal cells.	sm70ee	33-39	cAMP responsive element binding protein 1	Mus musculus	107-111
28570746-6	2017	All these showed that LSPCs may mediate calcium signal and double messenger system through Ca2+ /CaMK II/CREB/BDNF and DG/PKC/MAPK signaling pathways to reverse the alteration caused by ELF-MF.	Calcium	40-47	cAMP responsive element binding protein 1	Mus musculus	105-109
30263674-5	2017	Subsequently, the betaine-stimulated melanocytes showed inhibition of PKA-CREB signaling axis but activation of extracellular-signal-regulated kinase and AKT-GSK3beta signaling pathways.	Betaine	18-25	cAMP responsive element binding protein 1	Mus musculus	74-78
28959186-7	2017	Rosiglitazone was also found to activate the Akt/CREB pathway by increasing IGF-1R expression and IGF-1 protein levels, thereby playing an anti-apoptotic role in astrocytes.	Rosiglitazone	0-13	cAMP responsive element binding protein 1	Mus musculus	49-53
28887564-5	2017	Mechanistically, Y1 receptor signaling inhibits the production of cAMP in islets, which via CREB mediated pathways results in the down-regulation of several key enzymes in glycolysis and ATP production.	Cyclic AMP	66-70	cAMP responsive element binding protein 1	Mus musculus	92-96
28887564-5	2017	Mechanistically, Y1 receptor signaling inhibits the production of cAMP in islets, which via CREB mediated pathways results in the down-regulation of several key enzymes in glycolysis and ATP production.	Adenosine Triphosphate	187-190	cAMP responsive element binding protein 1	Mus musculus	92-96
28779377-7	2017	In addition, phosphorylated CREB on serine 133 which was shown to be involved in the induction of iNOS was inhibited by the combinations in stimulated cells.	Serine	36-42	cAMP responsive element binding protein 1	Mus musculus	28-32
28792471-8	2017	Among the sub-strains, scopolamine-treated C57BL/6N strains exhibited declined step-through latency, elevated acetylcholinesterase (AChE) activity and inflammatory protein expression, associated with reduced endogenous antioxidant levels and p-CREB/BDNF expression, compared to the control and tacrine-treated groups.	Scopolamine	23-34	cAMP responsive element binding protein 1	Mus musculus	244-248
28793909-12	2017	Mechanistically, [6]-Gingerol treatment upregulated and activated cAMP, PKA, and CREB in the pancreatic islets, which are critical components of GLP-1-mediated insulin secretion pathway.	gingerol	21-29	cAMP responsive element binding protein 1	Mus musculus	81-85
28419468-0	2017	Activation of the Akt-CREB signalling axis by a proline-rich heptapeptide confers resistance to stress-induced cell death and inflammation.	Proline	48-55	cAMP responsive element binding protein 1	Mus musculus	22-26
28666847-1	2017	The aim of this study was to investigate the molecular mechanism by which eicosapentaenoic acid (EPA) may exert neuroprotective effects through an "EPA-cyclic AMP response element-binding protein (CREB)" signaling pathway.	Eicosapentaenoic Acid	74-95	cAMP responsive element binding protein 1	Mus musculus	147-195
28666847-1	2017	The aim of this study was to investigate the molecular mechanism by which eicosapentaenoic acid (EPA) may exert neuroprotective effects through an "EPA-cyclic AMP response element-binding protein (CREB)" signaling pathway.	Eicosapentaenoic Acid	74-95	cAMP responsive element binding protein 1	Mus musculus	197-201
28666847-1	2017	The aim of this study was to investigate the molecular mechanism by which eicosapentaenoic acid (EPA) may exert neuroprotective effects through an "EPA-cyclic AMP response element-binding protein (CREB)" signaling pathway.	Eicosapentaenoic Acid	97-100	cAMP responsive element binding protein 1	Mus musculus	147-195
28666847-1	2017	The aim of this study was to investigate the molecular mechanism by which eicosapentaenoic acid (EPA) may exert neuroprotective effects through an "EPA-cyclic AMP response element-binding protein (CREB)" signaling pathway.	Eicosapentaenoic Acid	97-100	cAMP responsive element binding protein 1	Mus musculus	197-201
28666847-2	2017	The current study reveals that EPA modulates the exquisite interplay of interaction of CREB1 with the inhibitor of DNA binding (ID) and E2A family members, thereby delivering mechanistic insights into specific neural differentiation program.	Eicosapentaenoic Acid	31-34	cAMP responsive element binding protein 1	Mus musculus	87-92
28666847-4	2017	Together, these findings support the one-to-many binding mechanism of CREB1 and indicate that EPA treatment potentiates the integration of CREB dependent signaling with HLH/bHLH transcriptional network, adding specificity to the CREB1-mediated gene regulation during neural/glial differentiation.	Eicosapentaenoic Acid	94-97	cAMP responsive element binding protein 1	Mus musculus	70-75
28666847-4	2017	Together, these findings support the one-to-many binding mechanism of CREB1 and indicate that EPA treatment potentiates the integration of CREB dependent signaling with HLH/bHLH transcriptional network, adding specificity to the CREB1-mediated gene regulation during neural/glial differentiation.	Eicosapentaenoic Acid	94-97	cAMP responsive element binding protein 1	Mus musculus	70-74
28666847-4	2017	Together, these findings support the one-to-many binding mechanism of CREB1 and indicate that EPA treatment potentiates the integration of CREB dependent signaling with HLH/bHLH transcriptional network, adding specificity to the CREB1-mediated gene regulation during neural/glial differentiation.	Eicosapentaenoic Acid	94-97	cAMP responsive element binding protein 1	Mus musculus	229-234
28753056-0	2017	Gamma-Irradiated Luteolin Inhibits 3-Isobutyl-1-Methylxanthine-Induced Melanogenesis Through the Regulation of CREB/MITF, PI3K/Akt, and ERK Pathways in B16BL6 Melanoma Cells.	1-Methyl-3-isobutylxanthine	35-62	cAMP responsive element binding protein 1	Mus musculus	111-115
28595081-0	2017	Pioglitazone attenuates lipopolysaccharide-induced depression-like behaviors, modulates NF-kappaB/IL-6/STAT3, CREB/BDNF pathways and central serotonergic neurotransmission in mice.	Pioglitazone	0-12	cAMP responsive element binding protein 1	Mus musculus	110-114
28515141-4	2017	Here we report that following the acute induction of gluconeogenic genes Glucose 6 phosphatase (G6Pase) and Phosphoenolpyruvate carboxykinase (Pepck) expression through cAMP-response element-binding protein (CREB), glucagon triggers a second delayed phase of fatty acid oxidation genes Acyl-coenzyme A oxidase (Aox) and Carnitine palmitoyltransferase 1a (Cpt1a) expression via extracellular cAMP.	Fatty Acids	259-269	cAMP responsive element binding protein 1	Mus musculus	169-206
28515141-4	2017	Here we report that following the acute induction of gluconeogenic genes Glucose 6 phosphatase (G6Pase) and Phosphoenolpyruvate carboxykinase (Pepck) expression through cAMP-response element-binding protein (CREB), glucagon triggers a second delayed phase of fatty acid oxidation genes Acyl-coenzyme A oxidase (Aox) and Carnitine palmitoyltransferase 1a (Cpt1a) expression via extracellular cAMP.	Fatty Acids	259-269	cAMP responsive element binding protein 1	Mus musculus	208-212
28515141-4	2017	Here we report that following the acute induction of gluconeogenic genes Glucose 6 phosphatase (G6Pase) and Phosphoenolpyruvate carboxykinase (Pepck) expression through cAMP-response element-binding protein (CREB), glucagon triggers a second delayed phase of fatty acid oxidation genes Acyl-coenzyme A oxidase (Aox) and Carnitine palmitoyltransferase 1a (Cpt1a) expression via extracellular cAMP.	Cyclic AMP	169-173	cAMP responsive element binding protein 1	Mus musculus	208-212
28684787-0	2017	Polysulfide Na2S4 regulates the activation of PTEN/Akt/CREB signaling and cytotoxicity mediated by 1,4-naphthoquinone through formation of sulfur adducts.	polysulfide	0-11	cAMP responsive element binding protein 1	Mus musculus	55-59
29108246-0	2017	MRP4 regulates ENaC-dependent CREB/COX-2/PGE2 signaling during embryo implantation.	Dinoprostone	41-45	cAMP responsive element binding protein 1	Mus musculus	30-34
29108246-5	2017	These results in together have revealed a previously undefined role of MRP4 in mediating ENaC-dependent CREB/COX-2/PGE2 signaling essential to embryo implantation with implication in cancer progression as well.	Dinoprostone	115-119	cAMP responsive element binding protein 1	Mus musculus	104-108
28607167-7	2017	CREB is necessary for both Dc-ODP and Pc-ODP, whereas SRF and MEF2 are only needed for Dc-ODP.	pc-odp	38-44	cAMP responsive element binding protein 1	Mus musculus	0-4
27324897-7	2017	The synaptic-related protein expression increased via activation of the cyclic AMP response element binding (CREB) protein/brain-derived neurotrophic factor (BDNF) signaling pathway induced by fluoxetine exposure.	Fluoxetine	193-203	cAMP responsive element binding protein 1	Mus musculus	72-107
27324897-7	2017	The synaptic-related protein expression increased via activation of the cyclic AMP response element binding (CREB) protein/brain-derived neurotrophic factor (BDNF) signaling pathway induced by fluoxetine exposure.	Fluoxetine	193-203	cAMP responsive element binding protein 1	Mus musculus	109-113
28536070-5	2017	Cotinine significantly improved visual recognition memory performance increased CREB phosphorylation and reduced cortical Tau phosphorylation.	Cotinine	0-8	cAMP responsive element binding protein 1	Mus musculus	80-84
28720858-6	2017	GSK-3beta deletion also suppressed the activity-dependent neural activation and calcium/calmodulin-dependent protein kinase II (CaMKII)/CaMKIV-cAMP response element binding protein (CREB) signaling.	Cyclic AMP	143-147	cAMP responsive element binding protein 1	Mus musculus	182-186
28416324-5	2017	E4BP4 was markedly induced by glucocorticoid (dexamethasone) via GR and cAMP response element-binding protein (CREB) during adipogenesis.	Dexamethasone	46-59	cAMP responsive element binding protein 1	Mus musculus	72-109
28416324-5	2017	E4BP4 was markedly induced by glucocorticoid (dexamethasone) via GR and cAMP response element-binding protein (CREB) during adipogenesis.	Dexamethasone	46-59	cAMP responsive element binding protein 1	Mus musculus	111-115
28607167-6	2017	We found that CREB, SRF, and MEF2 are all required for ODP, but have differential effects on Dc-ODP and Pc-ODP.	ISODECYL OCTYL PHTHALATE	55-58	cAMP responsive element binding protein 1	Mus musculus	14-18
28607167-6	2017	We found that CREB, SRF, and MEF2 are all required for ODP, but have differential effects on Dc-ODP and Pc-ODP.	dc-odp	93-99	cAMP responsive element binding protein 1	Mus musculus	14-18
28607167-6	2017	We found that CREB, SRF, and MEF2 are all required for ODP, but have differential effects on Dc-ODP and Pc-ODP.	pc-odp	104-110	cAMP responsive element binding protein 1	Mus musculus	14-18
28607167-7	2017	CREB is necessary for both Dc-ODP and Pc-ODP, whereas SRF and MEF2 are only needed for Dc-ODP.	dc-odp	27-33	cAMP responsive element binding protein 1	Mus musculus	0-4
28684787-0	2017	Polysulfide Na2S4 regulates the activation of PTEN/Akt/CREB signaling and cytotoxicity mediated by 1,4-naphthoquinone through formation of sulfur adducts.	Sodium tetrasulfide	12-17	cAMP responsive element binding protein 1	Mus musculus	55-59
28684787-0	2017	Polysulfide Na2S4 regulates the activation of PTEN/Akt/CREB signaling and cytotoxicity mediated by 1,4-naphthoquinone through formation of sulfur adducts.	1,4-naphthoquinone	99-117	cAMP responsive element binding protein 1	Mus musculus	55-59
28684787-0	2017	Polysulfide Na2S4 regulates the activation of PTEN/Akt/CREB signaling and cytotoxicity mediated by 1,4-naphthoquinone through formation of sulfur adducts.	Sulfur	139-145	cAMP responsive element binding protein 1	Mus musculus	55-59
28684787-5	2017	1,4-NQ, at up to 10 microM, increased phosphorylation of Akt and cAMP response element binding protein (CREB).	1,4-naphthoquinone	0-6	cAMP responsive element binding protein 1	Mus musculus	65-102
28684787-5	2017	1,4-NQ, at up to 10 microM, increased phosphorylation of Akt and cAMP response element binding protein (CREB).	1,4-naphthoquinone	0-6	cAMP responsive element binding protein 1	Mus musculus	104-108
28684787-7	2017	These bell-shaped dose curves for Akt and CREB activation were right-shifted in cells treated with both 1,4-NQ and Na2S4.	1,4-naphthoquinone	104-110	cAMP responsive element binding protein 1	Mus musculus	42-46
28684787-7	2017	These bell-shaped dose curves for Akt and CREB activation were right-shifted in cells treated with both 1,4-NQ and Na2S4.	Sodium tetrasulfide	115-120	cAMP responsive element binding protein 1	Mus musculus	42-46
28947959-10	2017	Collectively, our study identified ColXV as a novel downstream gene for CREB and could promote adipocyte differentiation, inhibit lipolysis through repressing cAMP/PKA signaling pathway and positively regulating adipogenic markers expressions by repressing the activity of maintenance methyltransferase Dnmt1.	Cyclic AMP	159-163	cAMP responsive element binding protein 1	Mus musculus	72-76
26860616-5	2017	To determine the causal role of corticosterone in the withdrawal-associated long-lasting WM deficits, we further show that a single intraperitoneal injection injection of metyrapone (an inhibitor of corticosterone synthesis) 30 minutes before testing, prevents withdrawal-associated WM deficits and reestablishes PFC activity, as assessed by increased phosphorylated C-AMP Response Element-binding protein (CREB) immunoreactivity in withdrawn mice.	Metyrapone	171-181	cAMP responsive element binding protein 1	Mus musculus	367-405
26860616-5	2017	To determine the causal role of corticosterone in the withdrawal-associated long-lasting WM deficits, we further show that a single intraperitoneal injection injection of metyrapone (an inhibitor of corticosterone synthesis) 30 minutes before testing, prevents withdrawal-associated WM deficits and reestablishes PFC activity, as assessed by increased phosphorylated C-AMP Response Element-binding protein (CREB) immunoreactivity in withdrawn mice.	Metyrapone	171-181	cAMP responsive element binding protein 1	Mus musculus	407-411
28450469-0	2017	Novel Phosphodiesterase 4 Inhibitor FCPR03 Alleviates Lipopolysaccharide-Induced Neuroinflammation by Regulation of the cAMP/PKA/CREB Signaling Pathway and NF-kappaB Inhibition.	FCPR03	36-42	cAMP responsive element binding protein 1	Mus musculus	129-133
28450469-11	2017	Our findings suggest that FCPR03 inhibits the neuroinflammatory response through the activation of cAMP/PKA/CREB signaling pathway and NF-kappaB inhibition.	Cyclic AMP	99-103	cAMP responsive element binding protein 1	Mus musculus	108-112
28589680-5	2017	Furthermore, we showed that ATRA promoted CNTF expression through CREB binding to its promoter region.	Tretinoin	28-32	cAMP responsive element binding protein 1	Mus musculus	66-70
28629115-0	2017	Osthole Enhances Osteogenesis in Osteoblasts by Elevating Transcription Factor Osterix via cAMP/CREB Signaling In Vitro and In Vivo.	osthol	0-7	cAMP responsive element binding protein 1	Mus musculus	96-100
28629115-7	2017	Mechanistic study showed osthole triggered the cAMP/CREB pathway through the elevation of the intracellular cAMP level and activation of the phosphorylation of the cAMP response element-binding protein (CREB).	osthol	25-32	cAMP responsive element binding protein 1	Mus musculus	52-56
28629115-7	2017	Mechanistic study showed osthole triggered the cAMP/CREB pathway through the elevation of the intracellular cAMP level and activation of the phosphorylation of the cAMP response element-binding protein (CREB).	osthol	25-32	cAMP responsive element binding protein 1	Mus musculus	164-201
28629115-7	2017	Mechanistic study showed osthole triggered the cAMP/CREB pathway through the elevation of the intracellular cAMP level and activation of the phosphorylation of the cAMP response element-binding protein (CREB).	osthol	25-32	cAMP responsive element binding protein 1	Mus musculus	203-207
28629115-7	2017	Mechanistic study showed osthole triggered the cAMP/CREB pathway through the elevation of the intracellular cAMP level and activation of the phosphorylation of the cAMP response element-binding protein (CREB).	Cyclic AMP	47-51	cAMP responsive element binding protein 1	Mus musculus	52-56
28629115-7	2017	Mechanistic study showed osthole triggered the cAMP/CREB pathway through the elevation of the intracellular cAMP level and activation of the phosphorylation of the cAMP response element-binding protein (CREB).	Cyclic AMP	47-51	cAMP responsive element binding protein 1	Mus musculus	164-201
28629115-7	2017	Mechanistic study showed osthole triggered the cAMP/CREB pathway through the elevation of the intracellular cAMP level and activation of the phosphorylation of the cAMP response element-binding protein (CREB).	Cyclic AMP	47-51	cAMP responsive element binding protein 1	Mus musculus	203-207
28629115-7	2017	Mechanistic study showed osthole triggered the cAMP/CREB pathway through the elevation of the intracellular cAMP level and activation of the phosphorylation of the cAMP response element-binding protein (CREB).	Cyclic AMP	108-112	cAMP responsive element binding protein 1	Mus musculus	52-56
28629115-8	2017	Blockage of cAMP/CREB downstream signals with protein kinase A (PKA) inhibitor KT5720 partially suppressed osthole-mediated osteogenesis by inhibiting the elevation of transcription factor, osterix.	KT 5720	79-85	cAMP responsive element binding protein 1	Mus musculus	17-21
28629115-8	2017	Blockage of cAMP/CREB downstream signals with protein kinase A (PKA) inhibitor KT5720 partially suppressed osthole-mediated osteogenesis by inhibiting the elevation of transcription factor, osterix.	osthol	107-114	cAMP responsive element binding protein 1	Mus musculus	17-21
28629115-10	2017	Osthole-mediated osteogenesis is related to activation of the cAMP/CREB signaling pathway and downstream osterix expression.	osthol	0-7	cAMP responsive element binding protein 1	Mus musculus	67-71
28629115-10	2017	Osthole-mediated osteogenesis is related to activation of the cAMP/CREB signaling pathway and downstream osterix expression.	Cyclic AMP	62-66	cAMP responsive element binding protein 1	Mus musculus	67-71
28244951-11	2017	RESULTS: In vitro, 100 mumol/L glutamate induced p-CREB and miR212/132-LNA.	Glutamic Acid	31-40	cAMP responsive element binding protein 1	Mus musculus	51-55
28611691-0	2017	Morphine Reward Promotes Cue-Sensitive Learning: Implication of Dorsal Striatal CREB Activity.	Morphine	0-8	cAMP responsive element binding protein 1	Mus musculus	80-84
27966087-4	2017	In addition, we attempted to verify if inosine treatment was capable of altering the immunocontent and phosphorylation of the transcription factor cyclic adenosine monophosphatate (cAMP) response-binding element protein (CREB) in mouse prefrontal cortex and hippocampus.	Inosine	39-46	cAMP responsive element binding protein 1	Mus musculus	221-225
27966087-4	2017	In addition, we attempted to verify if inosine treatment was capable of altering the immunocontent and phosphorylation of the transcription factor cyclic adenosine monophosphatate (cAMP) response-binding element protein (CREB) in mouse prefrontal cortex and hippocampus.	cyclic adenosine monophosphatate	147-179	cAMP responsive element binding protein 1	Mus musculus	221-225
27966087-4	2017	In addition, we attempted to verify if inosine treatment was capable of altering the immunocontent and phosphorylation of the transcription factor cyclic adenosine monophosphatate (cAMP) response-binding element protein (CREB) in mouse prefrontal cortex and hippocampus.	Cyclic AMP	181-185	cAMP responsive element binding protein 1	Mus musculus	221-225
28431607-12	2017	However, the effects of PRE084 on CaMKIV-TORC1-CREB and BDNF, even for learning and memory impairment, were antagonized by the co-administration of PEAQX, an antagonist of NR2A.	5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione	148-153	cAMP responsive element binding protein 1	Mus musculus	47-51
28915638-0	2017	Oleoylethanolamide inhibits alpha-melanocyte stimulating hormone-stimulated melanogenesis via ERK, Akt and CREB signaling pathways in B16 melanoma cells.	oleoylethanolamide	0-18	cAMP responsive element binding protein 1	Mus musculus	107-111
28915638-5	2017	Moreover, OEA activated ERK, Akt, p38 pathways and inhibits CREB pathway in alpha-MSH-stimulated B16 cells.	oleoylethanolamide	10-13	cAMP responsive element binding protein 1	Mus musculus	60-64
28515432-6	2017	Of special interest, CREB1 phosphorylation (S133 and S142), a key factor involved in calcium signaling and other pathways, was up-regulated in HS mice.	Calcium	85-92	cAMP responsive element binding protein 1	Mus musculus	21-26
28915638-8	2017	Our findings demonstrated that OEA is an effective inhibitor of hyperpigmentation through activation of ERK, Akt and p38 pathways, inhibition of the CREB pathway, and subsequent down-regulation of MITF, TRP-1 and tyrosinase production.	oleoylethanolamide	31-34	cAMP responsive element binding protein 1	Mus musculus	149-153
27435287-5	2017	Furthermore, the expressions of both the cAMP responsive element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) were significantly increased and the disturbance of AKT/GSK-3beta signalling pathway was markedly ameliorated in the hippocampus of astilbin-treated (40 mg/kg per day) group.	astilbin	265-273	cAMP responsive element binding protein 1	Mus musculus	41-80
28366776-0	2017	Involvement of Akt/GSK3beta/CREB signaling pathway on chronic omethoate induced depressive-like behavior and improvement effects of combined lithium chloride and astaxanthin treatment.	dimethoxon	62-71	cAMP responsive element binding protein 1	Mus musculus	28-32
28366776-0	2017	Involvement of Akt/GSK3beta/CREB signaling pathway on chronic omethoate induced depressive-like behavior and improvement effects of combined lithium chloride and astaxanthin treatment.	Lithium Chloride	141-157	cAMP responsive element binding protein 1	Mus musculus	28-32
28366776-0	2017	Involvement of Akt/GSK3beta/CREB signaling pathway on chronic omethoate induced depressive-like behavior and improvement effects of combined lithium chloride and astaxanthin treatment.	astaxanthine	162-173	cAMP responsive element binding protein 1	Mus musculus	28-32
28366776-5	2017	Moreover, the combined application of AST and LiCl had synergistic therapeutic effects compared to LiCl and AST treatment alone, the expression of p-GSK3beta, p-CREB, p-PI3K and p-Akt after combined LiCl-AST treatment were significantly higher than that with single drug application.	Lithium Chloride	46-50	cAMP responsive element binding protein 1	Mus musculus	161-165
28212844-11	2017	This study demonstrates that TSH activates CRTC2 via the TSHR/cAMP/PKA pathway, leading to the formation of a CRTC2:CREB complex and increases hepatic gluconeogenesis.	Thyrotropin	29-32	cAMP responsive element binding protein 1	Mus musculus	116-120
28212844-11	2017	This study demonstrates that TSH activates CRTC2 via the TSHR/cAMP/PKA pathway, leading to the formation of a CRTC2:CREB complex and increases hepatic gluconeogenesis.	Cyclic AMP	62-66	cAMP responsive element binding protein 1	Mus musculus	116-120
28465511-9	2017	Our findings suggest that berberine exerts antidepressant-like effects in ovariectomized mice, and 5-HT2 receptor activation may be partially related to the antidepressant-like effects of the berberine by BDNF-CREB and eEF2 pathways.	Berberine	192-201	cAMP responsive element binding protein 1	Mus musculus	210-214
27435287-5	2017	Furthermore, the expressions of both the cAMP responsive element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) were significantly increased and the disturbance of AKT/GSK-3beta signalling pathway was markedly ameliorated in the hippocampus of astilbin-treated (40 mg/kg per day) group.	astilbin	265-273	cAMP responsive element binding protein 1	Mus musculus	82-86
28456375-3	2017	When we examined the cAMP/CREB signaling in the hippocampus, decreased levels of cAMP and phosphorylated CREB were observed in the dentate gyrus (DG) of MPTP-treated mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	153-157	cAMP responsive element binding protein 1	Mus musculus	26-30
28148567-2	2017	Here, we show that high glucose induced cAMP response element-binding protein (CREB)-binding protein (CBP)-mediated H3K9/14 hyperacetylation in approximately 5000 gene promoters in glomerular mesangial cells, including those of Tgfb1, Tgfb3, and Ctgf, the major profibrotic factors that are known to drive diabetic renal fibrogenesis.	Glucose	24-31	cAMP responsive element binding protein 1	Mus musculus	40-77
28148567-2	2017	Here, we show that high glucose induced cAMP response element-binding protein (CREB)-binding protein (CBP)-mediated H3K9/14 hyperacetylation in approximately 5000 gene promoters in glomerular mesangial cells, including those of Tgfb1, Tgfb3, and Ctgf, the major profibrotic factors that are known to drive diabetic renal fibrogenesis.	Glucose	24-31	cAMP responsive element binding protein 1	Mus musculus	79-83
28148567-5	2017	Under hyperglycemia, cAMP production and PKA activity were markedly increased as a result of glucose transporter 1-mediated glucose influx that drives glucose metabolism and ATP production, which led to increased phosphorylation of p65 and CREB.	Cyclic AMP	21-25	cAMP responsive element binding protein 1	Mus musculus	240-244
28148567-5	2017	Under hyperglycemia, cAMP production and PKA activity were markedly increased as a result of glucose transporter 1-mediated glucose influx that drives glucose metabolism and ATP production, which led to increased phosphorylation of p65 and CREB.	Glucose	93-100	cAMP responsive element binding protein 1	Mus musculus	240-244
28148567-5	2017	Under hyperglycemia, cAMP production and PKA activity were markedly increased as a result of glucose transporter 1-mediated glucose influx that drives glucose metabolism and ATP production, which led to increased phosphorylation of p65 and CREB.	Glucose	124-131	cAMP responsive element binding protein 1	Mus musculus	240-244
28148567-5	2017	Under hyperglycemia, cAMP production and PKA activity were markedly increased as a result of glucose transporter 1-mediated glucose influx that drives glucose metabolism and ATP production, which led to increased phosphorylation of p65 and CREB.	Adenosine Triphosphate	174-177	cAMP responsive element binding protein 1	Mus musculus	240-244
28456375-3	2017	When we examined the cAMP/CREB signaling in the hippocampus, decreased levels of cAMP and phosphorylated CREB were observed in the dentate gyrus (DG) of MPTP-treated mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	153-157	cAMP responsive element binding protein 1	Mus musculus	105-109
28456375-4	2017	Administration of rolipram improved the memory deficits with concomitant recovery of cAMP and phosphorylated CREB levels, suggesting that reduced cAMP/CREB signaling in the DG leads to cognitive impairment in MPTP-treated mice.	Rolipram	18-26	cAMP responsive element binding protein 1	Mus musculus	109-113
28456375-4	2017	Administration of rolipram improved the memory deficits with concomitant recovery of cAMP and phosphorylated CREB levels, suggesting that reduced cAMP/CREB signaling in the DG leads to cognitive impairment in MPTP-treated mice.	Rolipram	18-26	cAMP responsive element binding protein 1	Mus musculus	151-155
28456375-4	2017	Administration of rolipram improved the memory deficits with concomitant recovery of cAMP and phosphorylated CREB levels, suggesting that reduced cAMP/CREB signaling in the DG leads to cognitive impairment in MPTP-treated mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	209-213	cAMP responsive element binding protein 1	Mus musculus	151-155
27957816-7	2017	The AA-dependent differentiation of embryonic stem cells was shown to involve a p38 MAPK/CREB pathway, probably stimulated by cAMP via adenylate cyclases.	Cyclic AMP	126-130	cAMP responsive element binding protein 1	Mus musculus	89-93
27834392-3	2017	In the present study, we find that Nr4a gene expression after learning requires the cAMP-response element binding (CREB) interaction domain of the histone acetyltransferase CREB-binding protein (CBP).	Cyclic AMP	84-88	cAMP responsive element binding protein 1	Mus musculus	115-119
27013468-9	2017	Collectively, these results suggest that puerarin may ameliorate the SNI-induced depression and pain via activating ERK, CREB, and BDNF pathways.	puerarin	41-49	cAMP responsive element binding protein 1	Mus musculus	121-125
28435972-8	2017	ELISA and Western blot experiments showed that the Triagonist up-regulated the levels of cAMP, PKA and p-CREB in the hippocampus of 3xTg-AD mice.	Cyclic AMP	89-93	cAMP responsive element binding protein 1	Mus musculus	105-109
28435972-9	2017	These results indicate that GLP-1/GIP/Gcg receptor Triagonist can improve the cognitive behaviors in 3xTg-AD mice, and the up-regulation of hippocampal cAMP/PKA/CREB signal pathway may mediate the neuroprotection of the Triagonist, suggesting that the GLP-1/GIP/Gcg receptor Triagonist may be a novel therapeutic strategy for the treatment of AD.	Cyclic AMP	152-156	cAMP responsive element binding protein 1	Mus musculus	161-165
28366931-0	2017	Hydrocortisone-induced parkin prevents dopaminergic cell death via CREB pathway in Parkinson"s disease model.	Hydrocortisone	0-14	cAMP responsive element binding protein 1	Mus musculus	67-71
28275781-6	2017	It also reversed scopolamine-induced reduction in the hippocampal brain-derived neurotrophic factor (BDNF) and the cAMP response element-binding protein (CREB) mRNA expression.	Scopolamine	17-28	cAMP responsive element binding protein 1	Mus musculus	115-152
28275781-6	2017	It also reversed scopolamine-induced reduction in the hippocampal brain-derived neurotrophic factor (BDNF) and the cAMP response element-binding protein (CREB) mRNA expression.	Scopolamine	17-28	cAMP responsive element binding protein 1	Mus musculus	154-158
28267559-8	2017	These results suggested an intriguing possibility that MeHg-induced neuronal degeneration was caused by site-specific neural hyperactivity triggered by the activation of MAPK and PKA/CREB pathways followed by c-fos and BDNF upregulation.	mehg	55-59	cAMP responsive element binding protein 1	Mus musculus	183-187
28366931-6	2017	Hydrocortisone-activated parkin expression was mediated by CREB pathway since gRNA to CREB abolished hydrocortisone"s ability to induce parkin.	Hydrocortisone	0-14	cAMP responsive element binding protein 1	Mus musculus	59-63
28366931-6	2017	Hydrocortisone-activated parkin expression was mediated by CREB pathway since gRNA to CREB abolished hydrocortisone"s ability to induce parkin.	Hydrocortisone	0-14	cAMP responsive element binding protein 1	Mus musculus	86-90
28366931-6	2017	Hydrocortisone-activated parkin expression was mediated by CREB pathway since gRNA to CREB abolished hydrocortisone"s ability to induce parkin.	Hydrocortisone	101-115	cAMP responsive element binding protein 1	Mus musculus	59-63
28366931-6	2017	Hydrocortisone-activated parkin expression was mediated by CREB pathway since gRNA to CREB abolished hydrocortisone"s ability to induce parkin.	Hydrocortisone	101-115	cAMP responsive element binding protein 1	Mus musculus	86-90
28366931-8	2017	Our results showed that hydrocortisone could stimulate parkin expression via CREB pathway and the induced parkin expression was accountable for its neuroprotective effect.	Hydrocortisone	24-38	cAMP responsive element binding protein 1	Mus musculus	77-81
28235598-13	2017	Moreover, rolipram reversed the reduction of p-CREB and PSD95.	Rolipram	10-18	cAMP responsive element binding protein 1	Mus musculus	47-51
28235481-7	2017	Y109 is required for the Olfr544 activation by AzA which, in turn, stimulates the Olfr544-dependent CREB-PGC-1alpha signaling axis and is followed by the induction of mitochondrial biogenesis in Olfr544 wild-type transfected Hana3A cells, but not in mock or Y109A mutant transfected cells.	azelaic acid	47-50	cAMP responsive element binding protein 1	Mus musculus	100-104
28211012-8	2017	As an underlying mechanism, we demonstrated that the presence of F4/80 abrogated the effect of RANKL on the phosphorylation of CREB and activated the expression of IFN-beta, which are restored by cyclic AMP.	Cyclic AMP	196-206	cAMP responsive element binding protein 1	Mus musculus	127-131
28161224-4	2017	Prostanoids also induced ERK/CREB/IL-10 signaling pathway in DC that is more important for maturation of DC.	Prostaglandins	0-11	cAMP responsive element binding protein 1	Mus musculus	29-33
27278932-6	2017	RESULTS: The activation of A3AR by the specific agonist Cl-IB-MECA causes a marked reduction of CREB, mTOR, and ERK phosphorylation in kidney tissues of Pkd1 flox/-: Ksp-Cre polycystic mice and reduces cell growth in ADPKD cell lines, but not affects the kidney weight.	2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide	56-66	cAMP responsive element binding protein 1	Mus musculus	96-100
28043906-11	2017	Gsa deficiency reduced intestinal levels of cyclic adenosine monophosphate and transcriptional activity of the cyclic adenosine monophosphate response element binding protein 1 (CREB1); this resulted in decreased expression of the forkhead box F1 gene (Foxf1) and protein, and contractile proteins, such as myosin heavy chain 11; actin, alpha2, smooth muscle, aorta; calponin 1; and myosin light chain kinase.	Cyclic AMP	111-141	cAMP responsive element binding protein 1	Mus musculus	178-183
26944285-6	2017	Fisetin treatment also markedly reversed Abeta1-42-induced synaptic dysfunction by increasing the levels of both presynaptic (SYN and SNAP-25) and postsynaptic proteins (PSD-95, SNAP-23, p-GluR1 (Ser 845), p-CREB (Ser 133) and p-CAMKII (Thr 286) and ultimately improved mouse memory, as observed in the Morris water maze test.	fisetin	0-7	cAMP responsive element binding protein 1	Mus musculus	208-212
28065587-7	2017	Taken together, our data demonstrated that the reversal effect of FFPM on cognitive deficits in APP/PS1 transgenic mice might be related to stimulation of the cAMP/PKA/CREB/BDNF pathway and anti-inflammatory effects.	Cyclic AMP	159-163	cAMP responsive element binding protein 1	Mus musculus	168-172
27979612-5	2017	Cilostazol also increased the number of cells containing phosphorylated cAMP-responsive element binding protein (CREB), a downstream component of the cAMP pathway.	Cilostazol	0-10	cAMP responsive element binding protein 1	Mus musculus	72-111
28110215-0	2017	Neuroprotective action of N-acetyl serotonin in oxidative stress-induced apoptosis through the activation of both TrkB/CREB/BDNF pathway and Akt/Nrf2/Antioxidant enzyme in neuronal cells.	N-acetylserotonin	26-44	cAMP responsive element binding protein 1	Mus musculus	119-123
27979612-5	2017	Cilostazol also increased the number of cells containing phosphorylated cAMP-responsive element binding protein (CREB), a downstream component of the cAMP pathway.	Cilostazol	0-10	cAMP responsive element binding protein 1	Mus musculus	113-117
27979612-5	2017	Cilostazol also increased the number of cells containing phosphorylated cAMP-responsive element binding protein (CREB), a downstream component of the cAMP pathway.	Cyclic AMP	72-76	cAMP responsive element binding protein 1	Mus musculus	113-117
28110215-7	2017	Additionally, NAS improved phosphorylation of tropomyosin-related kinase receptor B (TrkB) and cAMP response element-binding protein (CREB) as well as expression of brain-derived neurotrophic factor (BDNF), whereas the inclusion of each inhibitor of JNK, p38 or Akt neutralized the neuroprotective effect of NAS, but not that of ERK.	N-acetylserotonin	14-17	cAMP responsive element binding protein 1	Mus musculus	95-132
28302174-10	2017	The stimulatory effects of pregnenolone, 22(R)-diol and hHDL3 on CREB phosphorylation was abolished by a specific p38 MAPK inhibitor, SB203580.	22(r)-diol	41-51	cAMP responsive element binding protein 1	Mus musculus	65-69
28110215-7	2017	Additionally, NAS improved phosphorylation of tropomyosin-related kinase receptor B (TrkB) and cAMP response element-binding protein (CREB) as well as expression of brain-derived neurotrophic factor (BDNF), whereas the inclusion of each inhibitor of JNK, p38 or Akt neutralized the neuroprotective effect of NAS, but not that of ERK.	N-acetylserotonin	14-17	cAMP responsive element binding protein 1	Mus musculus	134-138
28319198-8	2017	We found that METH activates CREB binding to the Shati/Nat8L promoter to induce the Shati/Nat8L mRNA expression.	Methamphetamine	14-18	cAMP responsive element binding protein 1	Mus musculus	29-33
28319198-9	2017	Furthermore, the dopamine D1 receptor antagonist SCH23390, but not the dopamine D2 receptor antagonist sulpiride, inhibited the upregulation of Shati/Nat8L and CREB activities in the mouse NAc slices.	SCH 23390	49-57	cAMP responsive element binding protein 1	Mus musculus	160-164
28319198-11	2017	These results showed that the Shati/Nat8L mRNA was increased by METH-induced CREB pathway via dopamine D1 receptor signaling in mouse NAc.	Methamphetamine	64-68	cAMP responsive element binding protein 1	Mus musculus	77-81
28302174-6	2017	RESULTS: Treatment of Y1 cells with H2O2 greatly enhanced the phosphorylation of both p38 MAPK and CREB protein.	Hydrogen Peroxide	36-40	cAMP responsive element binding protein 1	Mus musculus	99-103
28108322-7	2017	Additionally, administration of ZBD-2 inhibited decreases in the expression of synaptic plasticity-related signaling proteins, including brain-derived neurotrophic factor (BDNF) and cyclic AMP-responsive element binding protein (CREB).	Cyclic AMP	182-192	cAMP responsive element binding protein 1	Mus musculus	229-233
28302174-10	2017	The stimulatory effects of pregnenolone, 22(R)-diol and hHDL3 on CREB phosphorylation was abolished by a specific p38 MAPK inhibitor, SB203580.	SB 203580	134-142	cAMP responsive element binding protein 1	Mus musculus	65-69
28302174-10	2017	The stimulatory effects of pregnenolone, 22(R)-diol and hHDL3 on CREB phosphorylation was abolished by a specific p38 MAPK inhibitor, SB203580.	Pregnenolone	27-39	cAMP responsive element binding protein 1	Mus musculus	65-69
28302174-13	2017	CONCLUSION: Our data demonstrate induction of a ROS/p38 MAPK -mediated feedback inhibitory pathway by oxy-cholesterol and steroid intermediates and products attenuates steroidogenesis via inhibition of CREB transcriptional activity.	ros	48-51	cAMP responsive element binding protein 1	Mus musculus	202-206
28302174-13	2017	CONCLUSION: Our data demonstrate induction of a ROS/p38 MAPK -mediated feedback inhibitory pathway by oxy-cholesterol and steroid intermediates and products attenuates steroidogenesis via inhibition of CREB transcriptional activity.	oxy-cholesterol	102-117	cAMP responsive element binding protein 1	Mus musculus	202-206
28302174-13	2017	CONCLUSION: Our data demonstrate induction of a ROS/p38 MAPK -mediated feedback inhibitory pathway by oxy-cholesterol and steroid intermediates and products attenuates steroidogenesis via inhibition of CREB transcriptional activity.	Steroids	122-129	cAMP responsive element binding protein 1	Mus musculus	202-206
28157379-7	2017	LPA induced time-dependent phosphorylation of serum response factor (SRF) and CRE-binding protein (CREB) in mouse SMCs.	lysophosphatidic acid	0-3	cAMP responsive element binding protein 1	Mus musculus	78-97
28051915-6	2017	Furthermore, alisol B reduced the phosphorylation of CREB and maintained the activation of ERK1/2.	alisol B	13-21	cAMP responsive element binding protein 1	Mus musculus	53-57
28051915-7	2017	These results suggest that the reduction in melanin production by alisol B is due to the downregulation of MITF through the suppression of CREB and activation of ERK and that alisol B may be useful as a new whitening agent.	alisol B	66-74	cAMP responsive element binding protein 1	Mus musculus	139-143
28157379-7	2017	LPA induced time-dependent phosphorylation of serum response factor (SRF) and CRE-binding protein (CREB) in mouse SMCs.	lysophosphatidic acid	0-3	cAMP responsive element binding protein 1	Mus musculus	99-103
28280456-0	2017	Magnesium Elevation Promotes Neuronal Differentiation While Suppressing Glial Differentiation of Primary Cultured Adult Mouse Neural Progenitor Cells through ERK/CREB Activation.	Magnesium	0-9	cAMP responsive element binding protein 1	Mus musculus	162-166
28245593-8	2017	TNFalpha and PGE2 increased the expression of RANKL, NFAT cytoplasmic-1 (NFATc1), cAMP response element-binding protein (CREB), and cyclooxygenase 2 (COX2); which increment was suppressed by indomethacin, a COX inhibitor.	Dinoprostone	13-17	cAMP responsive element binding protein 1	Mus musculus	82-119
28245593-8	2017	TNFalpha and PGE2 increased the expression of RANKL, NFAT cytoplasmic-1 (NFATc1), cAMP response element-binding protein (CREB), and cyclooxygenase 2 (COX2); which increment was suppressed by indomethacin, a COX inhibitor.	Dinoprostone	13-17	cAMP responsive element binding protein 1	Mus musculus	121-125
28245593-10	2017	PGE2 induced the binding of CREB to the RANKL promoter, whereas TNFalpha increased the binding of both CREB and NFATc1 to this promoter through a process blocked by indomethacin.	Dinoprostone	0-4	cAMP responsive element binding protein 1	Mus musculus	28-32
28245593-10	2017	PGE2 induced the binding of CREB to the RANKL promoter, whereas TNFalpha increased the binding of both CREB and NFATc1 to this promoter through a process blocked by indomethacin.	Indomethacin	165-177	cAMP responsive element binding protein 1	Mus musculus	103-107
28280456-13	2017	Magnesium elevation promoted neural differentiation while suppressing glial cell differentiation, possibly via ERK-induced CREB activation.	Magnesium	0-9	cAMP responsive element binding protein 1	Mus musculus	123-127
27979980-13	2017	These results indicate that heat increases IL-6 in skeletal muscle cells through the TRPV1, PKC, and CREB signal transduction pathway.NEW &amp; NOTEWORTHY Heat increases the release of interleukin-6 (IL-6) from skeletal muscle cells.	Adenosine Monophosphate	139-142	cAMP responsive element binding protein 1	Mus musculus	101-105
28102395-7	2017	Importantly, sesamol treatment up-regulated brain insulin signaling by stimulating IRS-1/AKT as well as ERK/CREB/BDNF pathways; meanwhile it down-regulated neuronal death signaling GSK3beta and JNK.	sesamol	13-20	cAMP responsive element binding protein 1	Mus musculus	108-112
28280456-11	2017	Moreover, magnesium elevation enhanced the activation of both ERK and CREB.	Magnesium	10-19	cAMP responsive element binding protein 1	Mus musculus	70-74
28275711-4	2017	Given the ability of MSK1 to regulate gene expression via the phosphorylation of cAMP response element binding protein (CREB) at serine 133 (S133), MSK1 is a plausible candidate as a prime regulator of transcription underpinning synaptic plasticity and learning and memory.	Serine	129-135	cAMP responsive element binding protein 1	Mus musculus	81-118
28275711-4	2017	Given the ability of MSK1 to regulate gene expression via the phosphorylation of cAMP response element binding protein (CREB) at serine 133 (S133), MSK1 is a plausible candidate as a prime regulator of transcription underpinning synaptic plasticity and learning and memory.	Serine	129-135	cAMP responsive element binding protein 1	Mus musculus	120-124
28028849-16	2017	The G protein-coupled receptor 43 and p-CREB (Ser133) were significantly stimulated by SB.	Butyric Acid	87-89	cAMP responsive element binding protein 1	Mus musculus	40-44
27836585-8	2017	Interestingly, sildenafil administration increased memory performance, decreased oxidative stress, and increased neuroprotection in the hippocampus region of noise alone-induced mice likely through affecting memory related pathways such as cGMP/PKG/CREB and p25/CDK5, and induction of free radical scavengers such as SOD1, SOD2, SOD3, Prdx5, and catalase in the brain of stressed mice.	Sildenafil Citrate	15-25	cAMP responsive element binding protein 1	Mus musculus	249-253
28208711-5	2017	Phosphorylation of the cyclic adenosine monophosphate response element binding protein (CREB) was increased in the striatum, hippocampus, and midbrain of mice receiving combined treatment compared to treatment with either drug alone, particularly in the neurons of the striatum and hippocampus, and dopaminergic neurons of the midbrain.	Cyclic AMP	23-53	cAMP responsive element binding protein 1	Mus musculus	88-92
28208711-6	2017	Our results suggest that APZ may augment the antidepressant effects of CLS via co-regulation of the CREB signaling pathway, resulting in the synergistic enhancement of their neuroprotective effects.	Cilostazol	71-74	cAMP responsive element binding protein 1	Mus musculus	100-104
27735126-5	2017	Sulforaphane elevated levels of synaptic TrkB signaling pathway components, including CREB, CaMKII, ERK, and Akt in both primary cortical neurons and 3 x Tg-AD mice.	sulforaphane	0-12	cAMP responsive element binding protein 1	Mus musculus	86-90
27822668-9	2017	CIHH upregulated the expressions of BDNF, phosphorylated CREB, ERK1/2 and TrkB with or without ischemia.	cihh	0-4	cAMP responsive element binding protein 1	Mus musculus	57-61
27470063-4	2017	In accordance with previous reports, oleanolic acid enhanced extracellular-signal-regulated kinase 1/2 (ERK1/2) and cAMP response element-binding protein (CREB) phosphorylation and brain-derived neurotrophic factor (BDNF) expression in the hippocampus.	Oleanolic Acid	37-51	cAMP responsive element binding protein 1	Mus musculus	116-153
27470063-4	2017	In accordance with previous reports, oleanolic acid enhanced extracellular-signal-regulated kinase 1/2 (ERK1/2) and cAMP response element-binding protein (CREB) phosphorylation and brain-derived neurotrophic factor (BDNF) expression in the hippocampus.	Oleanolic Acid	37-51	cAMP responsive element binding protein 1	Mus musculus	155-159
27470063-7	2017	Together, these results imply that oleanolic acid ameliorates scopolamine-induced memory impairment by modulating the BDNF-ERK1/2-CREB pathway through TrkB activation in mice, suggesting that oleanolic acid would be a potential therapeutic agent for the treatment of cognitive deficits.	Oleanolic Acid	35-49	cAMP responsive element binding protein 1	Mus musculus	130-134
27470063-7	2017	Together, these results imply that oleanolic acid ameliorates scopolamine-induced memory impairment by modulating the BDNF-ERK1/2-CREB pathway through TrkB activation in mice, suggesting that oleanolic acid would be a potential therapeutic agent for the treatment of cognitive deficits.	Scopolamine	62-73	cAMP responsive element binding protein 1	Mus musculus	130-134
27470063-7	2017	Together, these results imply that oleanolic acid ameliorates scopolamine-induced memory impairment by modulating the BDNF-ERK1/2-CREB pathway through TrkB activation in mice, suggesting that oleanolic acid would be a potential therapeutic agent for the treatment of cognitive deficits.	Oleanolic Acid	192-206	cAMP responsive element binding protein 1	Mus musculus	130-134
27822668-11	2017	CIHH ameliorated ischemia-induced cognitive dysfunction through activation of ERK1/2-CREB-BDNF signaling pathway.	cihh	0-4	cAMP responsive element binding protein 1	Mus musculus	85-89
27933547-0	2017	Anti-Neuroinflammatory Effects of Fucoxanthin via Inhibition of Akt/NF-kappaB and MAPKs/AP-1 Pathways and Activation of PKA/CREB Pathway in Lipopolysaccharide-Activated BV-2 Microglial Cells.	fucoxanthin	34-45	cAMP responsive element binding protein 1	Mus musculus	124-128
27933547-8	2017	Subsequently, we found that Fx also mediates the reactive oxygen species (ROS) by activating protein kinase A (PKA)/cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) pathway, and promotes the production of brain-derived neurotrophic factor (BDNF).	Reactive Oxygen Species	74-77	cAMP responsive element binding protein 1	Mus musculus	188-192
28109109-0	2017	[Role of cAMP/CREB/BDNF signaling pathway in anti-depressive effect of vortioxetine in mice].	Vortioxetine	71-83	cAMP responsive element binding protein 1	Mus musculus	14-18
28109109-1	2017	OBJECTIVE: To investigate the effects of vortioxetine on cAMP/CREB/BDNF signal pathway.	Vortioxetine	41-53	cAMP responsive element binding protein 1	Mus musculus	62-66
28109109-8	2017	CONCLUSION: Vortioxetine improves the behaviors of mice with depression possibly by affecting the cAMP/CREB/BDNF signal pathway.	Vortioxetine	12-24	cAMP responsive element binding protein 1	Mus musculus	103-107
27939977-0	2017	Melatonin ameliorates amygdala-dependent emotional memory deficits in Tg2576 mice by up-regulating the CREB/c-Fos pathway.	Melatonin	0-9	cAMP responsive element binding protein 1	Mus musculus	103-107
27939977-5	2017	In the present study, we intraperitoneally injected Tg2576 mice with melatonin for 4 months and measured amygdala-dependent emotional memory using cued fear conditioning and a step-down passive avoidance test; the expression of c-Fos, Arc, phosphorylated CREB (pCREB) and other related genes were subsequently measured using Real-time polymerase chain reaction (RT-PCR) and Western blot in BLA.	Melatonin	69-78	cAMP responsive element binding protein 1	Mus musculus	255-259
28053025-3	2017	Here, using a single-molecule imaging technique, we investigated the activity dependence of DNA binding and dissociation events of cAMP-response element binding protein (CREB), a principal factor in activity-dependent transcription, in mouse cortical neurons.	Cyclic AMP	131-135	cAMP responsive element binding protein 1	Mus musculus	170-174
28054669-4	2017	Both compounds were equally potent in stimulating cAMP signaling in the mouse hippocampal cell line HT-22 leading to an increase in CREB phosphorylation.	Cyclic AMP	50-54	cAMP responsive element binding protein 1	Mus musculus	132-136
27840407-8	2017	ARDD also increased the expression of BDNF, CREB and GAP-43 in N1E115 cells, which was reversed by pretreatment with PD98059.	ardd	0-4	cAMP responsive element binding protein 1	Mus musculus	44-48
27840407-8	2017	ARDD also increased the expression of BDNF, CREB and GAP-43 in N1E115 cells, which was reversed by pretreatment with PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	117-124	cAMP responsive element binding protein 1	Mus musculus	44-48
27901267-9	2017	Similarly, the combination of alcohol and hypergravity suppressed the levels of STAT3, FOXO1/3, C/EBPbeta, and CREB, transcription factors necessary for cell survival.	Alcohols	30-37	cAMP responsive element binding protein 1	Mus musculus	111-115
27866157-7	2017	FFAR2 deficiency also enhanced the cAMP-PKA-CREB-HDAC pathway, downstream of FFAR2 signaling, and increased activation of the Wnt pathway, and raised the percentage of GR-1+ neutrophils in colonic lamina propria (LP) and increased infiltration of GR-1+ neutrophils into colonic polyps.	Cyclic AMP	35-39	cAMP responsive element binding protein 1	Mus musculus	44-48
29121799-0	2017	Pueraria lobate Inhibits RANKL-Mediated Osteoclastogenesis Via Downregulation of CREB/PGC1beta/c-Fos/NFATc1 Signaling.	pueraria lobate	0-15	cAMP responsive element binding protein 1	Mus musculus	81-85
27866157-8	2017	BRBs suppressed colonic polyp development and inhibited the cAMP-PKA-CREB-HDAC and Wnt pathways in the ApcMin/+ mice but not the ApcMin/+-FFAR2-/- mice.	Cyclic AMP	60-64	cAMP responsive element binding protein 1	Mus musculus	69-73
27789382-5	2016	(-)-Sesamin reduced increases in the retention transfer latency time in the elevated plus-maze test and N-methyl-d-aspartate receptor (NMDAR) expression and reduced decreases in the phosphorylation of extracellular signal-regulated kinase (ERK1/2) and cyclic AMP-response element binding protein (CREB) in the hippocampus.	sesamin	0-11	cAMP responsive element binding protein 1	Mus musculus	252-295
27796798-10	2017	In addition, our result suggests that PI3K/Akt and CREB pathways are related to the protective effect of alpha-LA.	Thioctic Acid	105-113	cAMP responsive element binding protein 1	Mus musculus	51-55
28005447-6	2017	These results suggest that GP-EX ameliorates habit learning memory deficits by activating dopaminergic neurons and spatial memory deficits by modulating NMDA receptor-ERK1/2-CREB system in MPTP-lesioned mice treated with L-DOPA.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	189-193	cAMP responsive element binding protein 1	Mus musculus	174-178
27833051-13	2017	The brain levels of p-VASP, p-CREB, and BDNF were higher in the TB mice compared with those in the CN mice.	Terbium	64-66	cAMP responsive element binding protein 1	Mus musculus	30-34
27833051-15	2017	These results strongly suggested that orally administered theobromine acted as a PDE inhibitor in the brain, and it augmented the cAMP/CREB/BDNF pathways and motor learning in mice.	Theobromine	58-69	cAMP responsive element binding protein 1	Mus musculus	135-139
28465762-5	2017	Paricalcitol increased phosphorylation of Akt and cyclic AMP responsive element binding protein (CREB) and suppressed nuclear factor-kappaB (NF-kappaB) in IR-exposed cells and cotreatment of EP4 antagonist or EP4 small interfering RNA blunted these signals.	paricalcitol	0-12	cAMP responsive element binding protein 1	Mus musculus	50-95
28465762-5	2017	Paricalcitol increased phosphorylation of Akt and cyclic AMP responsive element binding protein (CREB) and suppressed nuclear factor-kappaB (NF-kappaB) in IR-exposed cells and cotreatment of EP4 antagonist or EP4 small interfering RNA blunted these signals.	paricalcitol	0-12	cAMP responsive element binding protein 1	Mus musculus	97-101
29141245-0	2017	Roscovitine, a CDK5 Inhibitor, Alleviates Sevoflurane-Induced Cognitive Dysfunction via Regulation Tau/GSK3beta and ERK/PPARgamma/CREB Signaling.	Roscovitine	0-11	cAMP responsive element binding protein 1	Mus musculus	130-134
29141245-0	2017	Roscovitine, a CDK5 Inhibitor, Alleviates Sevoflurane-Induced Cognitive Dysfunction via Regulation Tau/GSK3beta and ERK/PPARgamma/CREB Signaling.	Sevoflurane	42-53	cAMP responsive element binding protein 1	Mus musculus	130-134
29141245-10	2017	CONCLUSIONS: Inhibiting CDK5 with roscovitine has neuroprotective effects against neuronal injury and cognitive dysfunction caused by sevoflurane anesthesia that are exerted via modulation of Tau/GSK3beta and ERK/PPARgamma/CREB signaling.	Roscovitine	34-45	cAMP responsive element binding protein 1	Mus musculus	223-227
27833051-3	2017	cAMP activates the cAMP-response element-binding protein (CREB), which is involved in a large variety of brain processes, including the induction of the brain-derived neurotrophic factor (BDNF).	Cyclic AMP	0-4	cAMP responsive element binding protein 1	Mus musculus	19-56
27833051-3	2017	cAMP activates the cAMP-response element-binding protein (CREB), which is involved in a large variety of brain processes, including the induction of the brain-derived neurotrophic factor (BDNF).	Cyclic AMP	0-4	cAMP responsive element binding protein 1	Mus musculus	58-62
27833051-5	2017	Thus, cAMP/CREB/BDNF pathways play an important role in learning and memory.	Cyclic AMP	6-10	cAMP responsive element binding protein 1	Mus musculus	11-15
27833051-6	2017	Here, we investigated whether orally administered theobromine could act as a PDE inhibitor centrally and affect cAMP/CREB/BDNF pathways and learning behavior in mice.	Theobromine	50-61	cAMP responsive element binding protein 1	Mus musculus	117-121
28152530-7	2017	The pathway by which CA inhibits dermatitis is related to the mitogen-activated protein kinase (MAPK)/extracellular signal regulated kinase (ERK)1/2/cAMP response element binding protein (CREB) pathway.	Cyclic AMP	149-153	cAMP responsive element binding protein 1	Mus musculus	188-192
27875294-0	2016	Spontaneous Glutamatergic Synaptic Activity Regulates Constitutive COX-2 Expression in Neurons: OPPOSING ROLES FOR THE TRANSCRIPTION FACTORS CREB (cAMP RESPONSE ELEMENT BINDING) PROTEIN AND Sp1 (STIMULATORY PROTEIN-1).	Cyclic AMP	147-151	cAMP responsive element binding protein 1	Mus musculus	141-145
28066242-5	2016	We demonstrated that the memory-enhancing effect of the S 38093 and Donepezil combination is mediated by its action on the septo-hippocampal circuitry, since it canceled out the reduction of CREB phosphorylation (pCREB) observed in these brain areas in vehicle-treated middle-aged animals.	Donepezil	68-77	cAMP responsive element binding protein 1	Mus musculus	191-195
27789382-5	2016	(-)-Sesamin reduced increases in the retention transfer latency time in the elevated plus-maze test and N-methyl-d-aspartate receptor (NMDAR) expression and reduced decreases in the phosphorylation of extracellular signal-regulated kinase (ERK1/2) and cyclic AMP-response element binding protein (CREB) in the hippocampus.	sesamin	0-11	cAMP responsive element binding protein 1	Mus musculus	297-301
27789382-7	2016	These results suggest that (-)-sesamin protects against habit learning memory deficits by activating the dopamine neuronal system, while spatial memory deficits are decreased by its modulatory effects on the NMDAR-ERK1/2-CREB system.	sesamin	27-38	cAMP responsive element binding protein 1	Mus musculus	221-225
28620651-13	2016	The results suggest that nuclear translocation of TORC3 plays a more important role than CREB phosphorylation in the observed changes in the cAMP driven reporter gene activity.	Cyclic AMP	141-145	cAMP responsive element binding protein 1	Mus musculus	89-93
27951657-0	2016	5-Methylcytosine (5mC) and 5-Hydroxymethylcytosine (5hmC) Enhance the DNA Binding of CREB1 to the C/EBP Half-Site Tetranucleotide GCAA.	5-Methylcytosine	0-16	cAMP responsive element binding protein 1	Mus musculus	85-90
27951657-0	2016	5-Methylcytosine (5mC) and 5-Hydroxymethylcytosine (5hmC) Enhance the DNA Binding of CREB1 to the C/EBP Half-Site Tetranucleotide GCAA.	5-Methylcytosine	18-21	cAMP responsive element binding protein 1	Mus musculus	85-90
27951657-0	2016	5-Methylcytosine (5mC) and 5-Hydroxymethylcytosine (5hmC) Enhance the DNA Binding of CREB1 to the C/EBP Half-Site Tetranucleotide GCAA.	5-hydroxymethylcytosine	27-50	cAMP responsive element binding protein 1	Mus musculus	85-90
27951657-0	2016	5-Methylcytosine (5mC) and 5-Hydroxymethylcytosine (5hmC) Enhance the DNA Binding of CREB1 to the C/EBP Half-Site Tetranucleotide GCAA.	5-hydroxymethylcytosine	52-56	cAMP responsive element binding protein 1	Mus musculus	85-90
27951657-0	2016	5-Methylcytosine (5mC) and 5-Hydroxymethylcytosine (5hmC) Enhance the DNA Binding of CREB1 to the C/EBP Half-Site Tetranucleotide GCAA.	tetranucleotide	114-129	cAMP responsive element binding protein 1	Mus musculus	85-90
27951657-2	2016	Using protein binding microarrays (PBMs) containing 60-mer DNA probes, we evaluated the effect of 5mC and 5hmC on one DNA strand on the double-stranded DNA binding of the mouse B-ZIP transcription factors (TFs) CREB1, ATF1, and JUND.	5-Methylcytosine	98-101	cAMP responsive element binding protein 1	Mus musculus	211-216
27951657-2	2016	Using protein binding microarrays (PBMs) containing 60-mer DNA probes, we evaluated the effect of 5mC and 5hmC on one DNA strand on the double-stranded DNA binding of the mouse B-ZIP transcription factors (TFs) CREB1, ATF1, and JUND.	5-hydroxymethylcytosine	106-110	cAMP responsive element binding protein 1	Mus musculus	211-216
27951657-3	2016	5mC inhibited binding of CREB1 to the canonical CRE half-site  GTCA but enhanced binding to the C/EBP half-site  GCAA.	5-Methylcytosine	0-3	cAMP responsive element binding protein 1	Mus musculus	25-30
27951657-4	2016	5hmC inhibited binding of CREB1 to all 8-mers except TGAT GCAA, where binding is enhanced.	5-hydroxymethylcytosine	0-4	cAMP responsive element binding protein 1	Mus musculus	26-31
27951657-7	2016	These results identify new DNA sequences that are well-bound by CREB1 and ATF1 only when they contain 5mC or 5hmC.	5-Methylcytosine	102-105	cAMP responsive element binding protein 1	Mus musculus	64-69
27951657-7	2016	These results identify new DNA sequences that are well-bound by CREB1 and ATF1 only when they contain 5mC or 5hmC.	5-hydroxymethylcytosine	109-113	cAMP responsive element binding protein 1	Mus musculus	64-69
27951657-8	2016	Analysis of two X-ray structures examines the consequences of 5mC and 5hmC on DNA binding by CREB and FOS JUN.	5-Methylcytosine	62-65	cAMP responsive element binding protein 1	Mus musculus	93-97
27951657-8	2016	Analysis of two X-ray structures examines the consequences of 5mC and 5hmC on DNA binding by CREB and FOS JUN.	5-hydroxymethylcytosine	70-74	cAMP responsive element binding protein 1	Mus musculus	93-97
27990119-0	2016	Oral Administration of Sitagliptin Activates CREB and Is Neuroprotective in Murine Model of Brain Trauma.	Sitagliptin Phosphate	23-34	cAMP responsive element binding protein 1	Mus musculus	45-49
27990119-11	2016	The CREB-regulated, mitochondrial antioxidant protein manganese superoxide dismutase (MnSOD) was increased in sitagliptin-treated mice (p &lt; 0.05).	Sitagliptin Phosphate	110-121	cAMP responsive element binding protein 1	Mus musculus	4-8
27190311-8	2016	CREB was found to bind to GSK3beta promoter and essential for cAMP-mediated regulation of GSK3beta.	Cyclic AMP	62-66	cAMP responsive element binding protein 1	Mus musculus	0-4
27190311-9	2016	Importantly, this regulation was demonstrated to be part of a feed-forward loop in which cAMP through CREB regulates GSK3beta expression, and GSK3beta in turn positively regulates cAMP generation.	Cyclic AMP	89-93	cAMP responsive element binding protein 1	Mus musculus	102-106
27190311-9	2016	Importantly, this regulation was demonstrated to be part of a feed-forward loop in which cAMP through CREB regulates GSK3beta expression, and GSK3beta in turn positively regulates cAMP generation.	Cyclic AMP	180-184	cAMP responsive element binding protein 1	Mus musculus	102-106
27544482-0	2016	Isoflurane-induced inactivation of CREB through histone deacetylase 4 is responsible for cognitive impairment in developing brain.	Isoflurane	0-10	cAMP responsive element binding protein 1	Mus musculus	35-39
27633503-0	2016	2-Ethoxybenzamide stimulates melanin synthesis in B16F1 melanoma cells via the CREB signaling pathway.	ethenzamide	0-17	cAMP responsive element binding protein 1	Mus musculus	79-83
27633503-0	2016	2-Ethoxybenzamide stimulates melanin synthesis in B16F1 melanoma cells via the CREB signaling pathway.	Melanins	29-36	cAMP responsive element binding protein 1	Mus musculus	79-83
27633503-6	2016	We also observed phosphorylation of cAMP response element-binding protein (CREB) following ETZ treatment.	ethenzamide	91-94	cAMP responsive element binding protein 1	Mus musculus	36-73
27633503-6	2016	We also observed phosphorylation of cAMP response element-binding protein (CREB) following ETZ treatment.	ethenzamide	91-94	cAMP responsive element binding protein 1	Mus musculus	75-79
27633503-9	2016	Together, our results indicate that ETZ induces melanin synthesis via CREB phosphorylation.	ethenzamide	36-39	cAMP responsive element binding protein 1	Mus musculus	70-74
27633503-9	2016	Together, our results indicate that ETZ induces melanin synthesis via CREB phosphorylation.	Melanins	48-55	cAMP responsive element binding protein 1	Mus musculus	70-74
27342118-3	2016	NaB induced the activation of CREB in hippocampal neurons via protein kinase A (PKA), which was responsible for the upregulation of plasticity-related molecules.	nab	0-3	cAMP responsive element binding protein 1	Mus musculus	30-34
27342118-5	2016	However, oral treatment of cinnamon and NaB increased spatial memory consolidation-induced activation of CREB and expression of plasticity-related molecules in the hippocampus of poor-learning mice and converted poor learners into good learners.	nab	40-43	cAMP responsive element binding protein 1	Mus musculus	105-109
27544482-3	2016	Here we have shown that administration of isoflurane (1.4%) for 2h leads to transcriptional inactivation of CREB which results in loss of dendritic outgrowth and decreased expression level of proteins essential for memory and cognitive functions, such as BDNF, and c-fos in the developing brain of mice at postnatal day 7 (PND7).	Isoflurane	42-52	cAMP responsive element binding protein 1	Mus musculus	108-112
27544482-3	2016	Here we have shown that administration of isoflurane (1.4%) for 2h leads to transcriptional inactivation of CREB which results in loss of dendritic outgrowth and decreased expression level of proteins essential for memory and cognitive functions, such as BDNF, and c-fos in the developing brain of mice at postnatal day 7 (PND7).	Deuterium	64-66	cAMP responsive element binding protein 1	Mus musculus	108-112
27677871-7	2016	Mechanistic studies revealed that Z-guggulsterone pretreatment reversed the scopolamine-induced increase in acetylcholinesterase (AchE) activity, as well as decreases in brain-derived neurotrophic factor (BDNF) protein expression and cAMP response element-binding protein (CREB), extracellular regulated kinase 1/2 (ERK1/2) and protein kinase B (Akt) phosphorylation levels in the hippocampus and cortex.	pregna-4,17-diene-3,16-dione	34-49	cAMP responsive element binding protein 1	Mus musculus	234-271
27677871-7	2016	Mechanistic studies revealed that Z-guggulsterone pretreatment reversed the scopolamine-induced increase in acetylcholinesterase (AchE) activity, as well as decreases in brain-derived neurotrophic factor (BDNF) protein expression and cAMP response element-binding protein (CREB), extracellular regulated kinase 1/2 (ERK1/2) and protein kinase B (Akt) phosphorylation levels in the hippocampus and cortex.	pregna-4,17-diene-3,16-dione	34-49	cAMP responsive element binding protein 1	Mus musculus	273-277
27677871-7	2016	Mechanistic studies revealed that Z-guggulsterone pretreatment reversed the scopolamine-induced increase in acetylcholinesterase (AchE) activity, as well as decreases in brain-derived neurotrophic factor (BDNF) protein expression and cAMP response element-binding protein (CREB), extracellular regulated kinase 1/2 (ERK1/2) and protein kinase B (Akt) phosphorylation levels in the hippocampus and cortex.	Scopolamine	76-87	cAMP responsive element binding protein 1	Mus musculus	234-271
27677871-7	2016	Mechanistic studies revealed that Z-guggulsterone pretreatment reversed the scopolamine-induced increase in acetylcholinesterase (AchE) activity, as well as decreases in brain-derived neurotrophic factor (BDNF) protein expression and cAMP response element-binding protein (CREB), extracellular regulated kinase 1/2 (ERK1/2) and protein kinase B (Akt) phosphorylation levels in the hippocampus and cortex.	Scopolamine	76-87	cAMP responsive element binding protein 1	Mus musculus	273-277
27677871-9	2016	Therefore, these findings demonstrate that Z-guggulsterone attenuates the scopolamine-induced memory impairments mainly through activation of the CREB-BDNF signaling pathway, thereby exhibiting memory-improving effects.	pregna-4,17-diene-3,16-dione	43-58	cAMP responsive element binding protein 1	Mus musculus	146-150
27677871-9	2016	Therefore, these findings demonstrate that Z-guggulsterone attenuates the scopolamine-induced memory impairments mainly through activation of the CREB-BDNF signaling pathway, thereby exhibiting memory-improving effects.	Scopolamine	74-85	cAMP responsive element binding protein 1	Mus musculus	146-150
28326743-0	2016	Dopamine receptors modulate T lymphocytes via inhibition of cAMP-CREB signaling pathway.	Cyclic AMP	60-64	cAMP responsive element binding protein 1	Mus musculus	65-69
27544482-4	2016	To elucidate the molecular mechanism, we found that exposure to isoflurane leads to an increase in nuclear translocation of HDAC4, which interacts with CREB in the nucleus.	Isoflurane	64-74	cAMP responsive element binding protein 1	Mus musculus	152-156
27544482-9	2016	Taken together, our study suggests that HDAC4-induced transcriptional inactivation of CREB is responsible for isoflurane-induced cognitive dysfunction in the brain.	Isoflurane	110-120	cAMP responsive element binding protein 1	Mus musculus	86-90
27809877-10	2016	Synaptamide increased intracellular cAMP levels, phosphorylation of PKA, and phosphorylation of CREB but suppressed LPS-induced nuclear translocation of NF-kappaB p65.	synaptamide	0-11	cAMP responsive element binding protein 1	Mus musculus	96-100
28326743-8	2016	However, quinpirole reduced both cAMP and phosphorylated CREB levels in Con A-activated lymphocytes.	Quinpirole	9-19	cAMP responsive element binding protein 1	Mus musculus	57-61
28326743-10	2016	CONCLUSIONS: D2-like receptors, principally dopamine D3 and D4 receptors, promote differentiation and function of T lymphocytes towards anti-inflammatory T cell subsets by a negative link to cAMP-CREB pathway.	Cyclic AMP	191-195	cAMP responsive element binding protein 1	Mus musculus	196-200
27431323-2	2016	Here we show that phosphorylation of CREB on a conserved cluster of Ser residues (the ATM/CK cluster) by the DNA damage-activated protein kinase ataxia-telangiectasia-mutated (ATM) and casein kinase1 (CK1) and casein kinase2 (CK2) positively and negatively regulates CREB-mediated transcription in a signal dependent manner.	Serine	68-71	cAMP responsive element binding protein 1	Mus musculus	37-41
27452800-0	2016	Thyroid-stimulating hormone improves insulin sensitivity in skeletal muscle cells via cAMP/PKA/CREB pathway-dependent upregulation of insulin receptor substrate-1 expression.	Thyrotropin	0-27	cAMP responsive element binding protein 1	Mus musculus	95-99
27452800-0	2016	Thyroid-stimulating hormone improves insulin sensitivity in skeletal muscle cells via cAMP/PKA/CREB pathway-dependent upregulation of insulin receptor substrate-1 expression.	Cyclic AMP	86-90	cAMP responsive element binding protein 1	Mus musculus	95-99
27452800-5	2016	TSH also stimulated Irs1 promoter activation; this stimulation was abolished by protein kinase A (PKA) inhibition using H89 or by mutation of the cAMP-response element site located at -1155 to -875 bp of the Irs1 promoter region, supporting a novel role of TSH activated-cAMP/PKA/CREB signaling in the regulation of Irs1 expression.	Cyclic AMP	146-150	cAMP responsive element binding protein 1	Mus musculus	280-284
27829153-5	2016	Importantly, MC4R activation rescues amyloid-beta-induced synaptic dysfunction via a Gs/cyclic AMP (cAMP)/PKA/cAMP-response element binding protein (CREB)-dependent mechanism.	Cyclic AMP	110-114	cAMP responsive element binding protein 1	Mus musculus	149-153
27431323-2	2016	Here we show that phosphorylation of CREB on a conserved cluster of Ser residues (the ATM/CK cluster) by the DNA damage-activated protein kinase ataxia-telangiectasia-mutated (ATM) and casein kinase1 (CK1) and casein kinase2 (CK2) positively and negatively regulates CREB-mediated transcription in a signal dependent manner.	Serine	68-71	cAMP responsive element binding protein 1	Mus musculus	267-271
27431323-3	2016	In response to genotoxic stress, phosphorylation of the ATM/CK cluster inhibited CREB-mediated gene expression, DNA binding activity and chromatin occupancy proportional to the number of modified Ser residues.	Serine	196-199	cAMP responsive element binding protein 1	Mus musculus	81-85
27431323-4	2016	Paradoxically, substoichiometric, ATM-independent, phosphorylation of the ATM/CK cluster potentiated bursts in CREB-mediated transcription by promoting recruitment of the CREB coactivator, cAMP-regulated transcriptional coactivators (CRTC2).	Cyclic AMP	189-193	cAMP responsive element binding protein 1	Mus musculus	111-115
27431323-4	2016	Paradoxically, substoichiometric, ATM-independent, phosphorylation of the ATM/CK cluster potentiated bursts in CREB-mediated transcription by promoting recruitment of the CREB coactivator, cAMP-regulated transcriptional coactivators (CRTC2).	Cyclic AMP	189-193	cAMP responsive element binding protein 1	Mus musculus	171-175
27717829-4	2016	Phosphorylation of extracellular signal-regulated kinase (ERK1/2) and cyclic AMP-responsive element binding protein (CREB), which were reduced by chronic EF stress, were increased by treatment with (-)-sesamin.	sesamin	198-209	cAMP responsive element binding protein 1	Mus musculus	70-115
27717829-4	2016	Phosphorylation of extracellular signal-regulated kinase (ERK1/2) and cyclic AMP-responsive element binding protein (CREB), which were reduced by chronic EF stress, were increased by treatment with (-)-sesamin.	sesamin	198-209	cAMP responsive element binding protein 1	Mus musculus	117-121
27792185-6	2016	Moreover, we found an increased expression of brain-derived neurotrophic factor (BDNF) and subsequently-activated extracellular-signal-regulated kinase (ERK)/cAMP response element binding (CREB) signaling pathway in the TEE-supplemented mice hippocampus.	Cyclic AMP	158-162	cAMP responsive element binding protein 1	Mus musculus	189-193
27498773-12	2016	Furthermore, DL0410 administration markedly decreased Abeta1-40/42 deposits in mouse cerebral cortices, and significantly up-regulated neurotrophic CREB/BDNF.	DL0410	13-19	cAMP responsive element binding protein 1	Mus musculus	148-152
27664956-16	2016	The surging catecholamines may activate ADRB2 and CREB, yielding increased angiogenesis and cellular proliferation in ectopic endometrium in mice with induced endometriosis.	Catecholamines	12-26	cAMP responsive element binding protein 1	Mus musculus	50-54
27387555-0	2016	Schisandra chinensis produces the antidepressant-like effects in repeated corticosterone-induced mice via the BDNF/TrkB/CREB signaling pathway.	Corticosterone	74-88	cAMP responsive element binding protein 1	Mus musculus	120-124
27329155-6	2016	PGD2 also enhances Akt and CREB/ATF-1 phosphorylation.	Prostaglandin D2	0-4	cAMP responsive element binding protein 1	Mus musculus	27-31
27329155-7	2016	Our results provide evidence for a role of PGD2 in the regulation of the oxidant/antioxidant status in Sertoli cells and, more importantly, in the modulation of LDH expression which takes place through ROS generation and the Akt-CREB/ATF-1 pathway.	Prostaglandin D2	43-47	cAMP responsive element binding protein 1	Mus musculus	229-233
27790091-10	2016	Protein kinase A (PKA) and Ca2+/cAMP-response element binding protein (CREB) phosphorylation were reduced in v-DG of MPTP-mice, which were reversed by D1-like receptor (D1R) agonist SKF38393, but not D2R agonist quinpirole.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	117-121	cAMP responsive element binding protein 1	Mus musculus	27-69
27790091-10	2016	Protein kinase A (PKA) and Ca2+/cAMP-response element binding protein (CREB) phosphorylation were reduced in v-DG of MPTP-mice, which were reversed by D1-like receptor (D1R) agonist SKF38393, but not D2R agonist quinpirole.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	117-121	cAMP responsive element binding protein 1	Mus musculus	71-75
27790091-10	2016	Protein kinase A (PKA) and Ca2+/cAMP-response element binding protein (CREB) phosphorylation were reduced in v-DG of MPTP-mice, which were reversed by D1-like receptor (D1R) agonist SKF38393, but not D2R agonist quinpirole.	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	182-190	cAMP responsive element binding protein 1	Mus musculus	71-75
27790091-10	2016	Protein kinase A (PKA) and Ca2+/cAMP-response element binding protein (CREB) phosphorylation were reduced in v-DG of MPTP-mice, which were reversed by D1-like receptor (D1R) agonist SKF38393, but not D2R agonist quinpirole.	Quinpirole	212-222	cAMP responsive element binding protein 1	Mus musculus	71-75
27240539-5	2016	Then, PGI2 accumulation in neuronal cells activates PKA/CREB and JNK/c-Jun signaling pathways by phosphorylation, which results in APH-1alpha/1beta expression.	Epoprostenol	6-10	cAMP responsive element binding protein 1	Mus musculus	56-60
27543340-3	2016	In this study, we focus on the melanogenesis of EMF-ELFs and find that 60-75Hz ELF-EMFs upregulate melanin synthesis by stimulated expression of tyrosinase and TRP-1 through inhibition of phosphorylation ERK, activation of CREB, and MITF up-regulation in B16F10 melanoma cells.	Melanins	99-106	cAMP responsive element binding protein 1	Mus musculus	223-227
27387555-2	2016	Here we evaluated the effect of an ethanol extract of the dried fruit of S. chinensis (EESC) on BDNF/TrkB/CREB signaling in the hippocampus and the prefrontal cortex.	Ethanol	35-42	cAMP responsive element binding protein 1	Mus musculus	106-110
27598965-2	2016	Fluoxetine, a selective serotonin reuptake inhibitor (SSRI) also known as Prozac, is widely used against depression, potentially by activating cAMP response element-binding protein (CREB) and increasing brain-derived neurotrophic factor (BDNF) through protein kinase A (PKA).	Fluoxetine	0-10	cAMP responsive element binding protein 1	Mus musculus	143-180
27689982-7	2016	These compounds also inhibited the phosphorylation of cyclic adenosine monophosphate (cAMP)-response element binding protein (CREB) in a dose-dependent manner.	Cyclic AMP	54-84	cAMP responsive element binding protein 1	Mus musculus	126-130
27689982-7	2016	These compounds also inhibited the phosphorylation of cyclic adenosine monophosphate (cAMP)-response element binding protein (CREB) in a dose-dependent manner.	Cyclic AMP	86-90	cAMP responsive element binding protein 1	Mus musculus	126-130
27475717-8	2016	Andrographolide inhibited the phosphorylation of PKA and the activation of cAMP response element-binding protein (CREB) in response to a differentiation cocktail, which led to attenuated C/EBPbeta expression.	andrographolide	0-15	cAMP responsive element binding protein 1	Mus musculus	75-112
27475717-8	2016	Andrographolide inhibited the phosphorylation of PKA and the activation of cAMP response element-binding protein (CREB) in response to a differentiation cocktail, which led to attenuated C/EBPbeta expression.	andrographolide	0-15	cAMP responsive element binding protein 1	Mus musculus	114-118
27475717-11	2016	Taken together, these results indicate that andrographolide has a potent anti-obesity action by inhibiting PKA-CREB-mediated C/EBPbeta expression as well as C/EBPbeta transcriptional activity, which halts MCE progression and attenuates C/EBPalpha and PPARgamma expression.	andrographolide	44-59	cAMP responsive element binding protein 1	Mus musculus	111-115
27461790-0	2016	Blockade of Cannabinoid CB1 receptor attenuates the acquisition of morphine-induced conditioned place preference along with a downregulation of ERK, CREB phosphorylation, and BDNF expression in the nucleus accumbens and hippocampus.	Morphine	67-75	cAMP responsive element binding protein 1	Mus musculus	149-153
27461790-8	2016	Both morphine CPP and NO-CPP induced an upregulation of ERK, CREB phosphorylation and BDNF expression.	Morphine	5-13	cAMP responsive element binding protein 1	Mus musculus	61-65
27461790-9	2016	Furthermore, pretreatment with AM251 before morphine attenuated the CPP acquisition and CB1R expression as well as the activation of ERK-CREB-BDNF cascade.	AM 251	31-36	cAMP responsive element binding protein 1	Mus musculus	137-141
27461790-11	2016	(2) CB1R antagonist mediated blockade of ERK-CREB-BDNF signaling activation in the NAc and hippocampus may be an important mechanism underlying the attenuation of morphine CPP.	Morphine	163-171	cAMP responsive element binding protein 1	Mus musculus	45-49
27598965-2	2016	Fluoxetine, a selective serotonin reuptake inhibitor (SSRI) also known as Prozac, is widely used against depression, potentially by activating cAMP response element-binding protein (CREB) and increasing brain-derived neurotrophic factor (BDNF) through protein kinase A (PKA).	Fluoxetine	0-10	cAMP responsive element binding protein 1	Mus musculus	182-186
27598965-2	2016	Fluoxetine, a selective serotonin reuptake inhibitor (SSRI) also known as Prozac, is widely used against depression, potentially by activating cAMP response element-binding protein (CREB) and increasing brain-derived neurotrophic factor (BDNF) through protein kinase A (PKA).	Fluoxetine	74-80	cAMP responsive element binding protein 1	Mus musculus	143-180
27598965-2	2016	Fluoxetine, a selective serotonin reuptake inhibitor (SSRI) also known as Prozac, is widely used against depression, potentially by activating cAMP response element-binding protein (CREB) and increasing brain-derived neurotrophic factor (BDNF) through protein kinase A (PKA).	Fluoxetine	74-80	cAMP responsive element binding protein 1	Mus musculus	182-186
27430240-7	2016	E2F-1 and CREB induced CD39 and CD73 expression, and were upregulated by adenosine and CGS21680.	Adenosine	73-82	cAMP responsive element binding protein 1	Mus musculus	10-14
27511023-6	2016	In addition, the phosphorylation of cAMP-response element binding protein (CREB), a transcription factor of Trx-1, was increased after treatment with epinephrine.	Epinephrine	150-161	cAMP responsive element binding protein 1	Mus musculus	36-73
27511023-6	2016	In addition, the phosphorylation of cAMP-response element binding protein (CREB), a transcription factor of Trx-1, was increased after treatment with epinephrine.	Epinephrine	150-161	cAMP responsive element binding protein 1	Mus musculus	75-79
27511023-7	2016	The block of CREB activation by H89 inhibited the acute epinephrine stress-induced Trx-1 and Hsp70 expression.	Epinephrine	56-67	cAMP responsive element binding protein 1	Mus musculus	13-17
27511023-8	2016	Taken together, our data suggest that acute stimuli of epinephrine induced Trx-1 expression through activating CREB and may represent a protective role against stress.	Epinephrine	55-66	cAMP responsive element binding protein 1	Mus musculus	111-115
27588067-5	2016	However, DHT promoted the expression of CREB, PSD95, SYN and Drebrin in the hippocampus of the castrated-DHT group.	Dihydrotestosterone	9-12	cAMP responsive element binding protein 1	Mus musculus	40-44
27430240-7	2016	E2F-1 and CREB induced CD39 and CD73 expression, and were upregulated by adenosine and CGS21680.	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	87-95	cAMP responsive element binding protein 1	Mus musculus	10-14
27430240-8	2016	Adenosine triphosphate (ATP) hydrolysis and adenosine generation were inhibited by the knockdown of E2F-1 or CREB, and were accelerated in the presence of CGS21680.	Adenosine Triphosphate	0-22	cAMP responsive element binding protein 1	Mus musculus	109-113
27430240-8	2016	Adenosine triphosphate (ATP) hydrolysis and adenosine generation were inhibited by the knockdown of E2F-1 or CREB, and were accelerated in the presence of CGS21680.	Adenosine Triphosphate	24-27	cAMP responsive element binding protein 1	Mus musculus	109-113
27430240-8	2016	Adenosine triphosphate (ATP) hydrolysis and adenosine generation were inhibited by the knockdown of E2F-1 or CREB, and were accelerated in the presence of CGS21680.	Adenosine	44-53	cAMP responsive element binding protein 1	Mus musculus	109-113
27430240-8	2016	Adenosine triphosphate (ATP) hydrolysis and adenosine generation were inhibited by the knockdown of E2F-1 or CREB, and were accelerated in the presence of CGS21680.	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine	155-163	cAMP responsive element binding protein 1	Mus musculus	109-113
27241020-5	2016	In SMN-deficient NSC34 cells, loganin increased cell viability, neurite length, and expressions of SMN, Gemin2, SMN-Gemin2 complex, p-Akt, p-GSK-3beta, p-CREB, BDNF and Bcl-2.	loganin	30-37	cAMP responsive element binding protein 1	Mus musculus	154-158
27554418-3	2016	Hippocampal memory consolidation requires phosphorylation of the cAMP Response Element-Binding protein, CREB, which upon phosphorylation promotes the transcription of genes necessary for long-term memory formation.	Cyclic AMP	65-69	cAMP responsive element binding protein 1	Mus musculus	104-108
27554418-4	2016	Rhythmic cAMP/ERK-MAPK activity upstream of CREB is a necessary component.	Cyclic AMP	9-13	cAMP responsive element binding protein 1	Mus musculus	44-48
27292126-10	2016	Knockdown of HDAC3 with siRNA significantly caused the increase of miR-10a, resulting in the decrease in CREB1 and FN expression in kidney of HFD/STZ mice.	Streptozocin	146-149	cAMP responsive element binding protein 1	Mus musculus	105-110
27235579-4	2016	Learning in the presence of acute nicotine increases the transcription of mitogen-activated protein kinase 8 (MAPK8, also known as JNK1), likely through a CREB-dependent mechanism.	Nicotine	34-42	cAMP responsive element binding protein 1	Mus musculus	155-159
27292126-7	2016	CREB1 and its downstream fibronectin (FN, extracellular matrix) were increased in HFD/STZ-treated mice, which was reversed by kidney miR-10a overexpression.	Streptozocin	86-89	cAMP responsive element binding protein 1	Mus musculus	0-5
27554094-14	2016	Interestingly, CREB was activated in the ECM brain and may protect against ROS/RNS stress.	ros	75-78	cAMP responsive element binding protein 1	Mus musculus	15-19
27554094-14	2016	Interestingly, CREB was activated in the ECM brain and may protect against ROS/RNS stress.	Radon	79-82	cAMP responsive element binding protein 1	Mus musculus	15-19
27220266-3	2016	Ample evidence suggests that Sildenafil exerts central effects through induction of Oxytocin (OT) secretion and CREB phosphorylation.	Sildenafil Citrate	29-39	cAMP responsive element binding protein 1	Mus musculus	112-116
27220266-4	2016	The aim of the present study is to evaluate potential roles of OT and CREB in the proconvulsant effects of Sildenafil.	Sildenafil Citrate	107-117	cAMP responsive element binding protein 1	Mus musculus	70-74
27220266-9	2016	At biochemical inspection, Sildenafil markedly increased CREB which was attenuated by coadministration of Atosiban.	Sildenafil Citrate	27-37	cAMP responsive element binding protein 1	Mus musculus	57-61
27220266-9	2016	At biochemical inspection, Sildenafil markedly increased CREB which was attenuated by coadministration of Atosiban.	atosiban	106-114	cAMP responsive element binding protein 1	Mus musculus	57-61
27220266-10	2016	The present study shows for the first time that OT release and the subsequent CREB phosphorylation are involved in the proconvulsant effects of acute Sildenafil treatment in an experimental model of seizure.	Sildenafil Citrate	150-160	cAMP responsive element binding protein 1	Mus musculus	78-82
27412767-3	2016	We suggest the involvement of CREB in HO-1 induction by ACTH/cAMP, as transfection of cells with a dominant-negative isoform of CREB (DN-CREB-M1) decreased, while overexpression of CREB increased HO-1 protein levels.	Cyclic AMP	61-65	cAMP responsive element binding protein 1	Mus musculus	128-132
26935863-6	2016	Quantitative RT-PCR revealed that CREB and BDNF gene expression levels were downregulated in diabetic mice, and these alterations were increased by exenatide treatment.	Exenatide	148-157	cAMP responsive element binding protein 1	Mus musculus	34-38
27412767-3	2016	We suggest the involvement of CREB in HO-1 induction by ACTH/cAMP, as transfection of cells with a dominant-negative isoform of CREB (DN-CREB-M1) decreased, while overexpression of CREB increased HO-1 protein levels.	Cyclic AMP	61-65	cAMP responsive element binding protein 1	Mus musculus	134-144
27412767-3	2016	We suggest the involvement of CREB in HO-1 induction by ACTH/cAMP, as transfection of cells with a dominant-negative isoform of CREB (DN-CREB-M1) decreased, while overexpression of CREB increased HO-1 protein levels.	Cyclic AMP	61-65	cAMP responsive element binding protein 1	Mus musculus	30-34
27412767-3	2016	We suggest the involvement of CREB in HO-1 induction by ACTH/cAMP, as transfection of cells with a dominant-negative isoform of CREB (DN-CREB-M1) decreased, while overexpression of CREB increased HO-1 protein levels.	Cyclic AMP	61-65	cAMP responsive element binding protein 1	Mus musculus	128-132
27412767-4	2016	Sequence screening of the murine HO-1 promoter revealed CRE-like sites located at -146 and -37 of the transcription start site and ChIP studies indicated that this region recruits phosphorylated CREB (pCREB) upon cAMP stimulation in Y1 cells.	Cyclic AMP	213-217	cAMP responsive element binding protein 1	Mus musculus	195-199
27412767-5	2016	In agreement, H89 (PKA inhibitor) or cotransfection with DN-CREB-M1 prevented the 8Br-cAMP-dependent increase in luciferase activity in cells transfected with pHO-1[-295/+74].LUC.	8-Bromoadenosine 5'-monophosphate	82-85	cAMP responsive element binding protein 1	Mus musculus	57-67
27412767-5	2016	In agreement, H89 (PKA inhibitor) or cotransfection with DN-CREB-M1 prevented the 8Br-cAMP-dependent increase in luciferase activity in cells transfected with pHO-1[-295/+74].LUC.	Cyclic AMP	86-90	cAMP responsive element binding protein 1	Mus musculus	57-67
27412767-8	2016	Finally, here we show a crosstalk between the cAMP/PKA and PI3K pathways that affects the binding of p-CREB to its cognate element in the murine promoter of the Hmox1 gene.	Cyclic AMP	46-50	cAMP responsive element binding protein 1	Mus musculus	103-107
26166359-10	2016	Our in vitro data showed that KN93 also significantly inhibited rIL-17A-induced CREB activation in primary cultured spinal neurons.	KN 93	30-34	cAMP responsive element binding protein 1	Mus musculus	80-84
25966970-12	2016	In addition, agmatine treatment in control mice increased noradrenaline, serotonin, and dopamine levels, CREB phosphorylation, mature BDNF and synaptotagmin I immunocontents, and reduced pro-BDNF immunocontent in the hippocampus.	Agmatine	13-21	cAMP responsive element binding protein 1	Mus musculus	105-109
28947953-9	2017	Further investigation of the molecular mechanisms of anti-metastatic activity revealed that DMGF can down-regulate the levels of key modulators of the Cdc42/Rac1 pathway to interfere in F-actin polymerization and suppress the formation of lamellipodia by reducing the phosphorylation of CREB.	7,7''-dimethoxyagastisflavone	92-96	cAMP responsive element binding protein 1	Mus musculus	287-291
27447833-11	2016	Creb, c-Jun, c-Fos, Bcl-2, Cast1, Nqo1, Sod1, and Cat were significantly increased in flibanserin-injected mice versus vehicle-injected mice.	flibanserin	86-97	cAMP responsive element binding protein 1	Mus musculus	0-4
26840030-7	2016	In contrast, in rat and mouse brains, downregulation of O-GlcNAcylation caused decreases in the phosphorylation of CREB at Ser133 and of tau at Ser214, but not at Thr205.	o-glcnacylation	56-71	cAMP responsive element binding protein 1	Mus musculus	115-119
28031098-1	2016	Objective To investigate the effects of mechanical strain on Ca2+-calmodulin dependent kinase (CaMK)-cAMP response element binding protein (CREB) signal pathway and proliferation of osteoblasts.Methods Using a four-point bending device, MC3T3-E1 cells were exposed to mechanical tensile strains of 2500 micros and 5000 micros at 0.5 Hz respectively.	Cyclic AMP	101-105	cAMP responsive element binding protein 1	Mus musculus	140-144
28031098-4	2016	The 2500 micros strain, a periodicity of 1 h/d for 3 days, activated calmodulin, elevated protein levels of CaMK II beta and p-CREB, and promoted cells proliferation, which were attenuated by pretreatment of verapamil or U73122.	Verapamil	208-217	cAMP responsive element binding protein 1	Mus musculus	125-131
26840030-8	2016	Reduction in O-GlcNAcylation through intracerebroventricular injection of 6-diazo-5-oxo-l-norleucine (DON), the inhibitor of glutamine fructose-6-phosphate amidotransferase, suppressed PKA-CREB signaling and impaired learning and memory in mice.	o-glcnacylation	13-28	cAMP responsive element binding protein 1	Mus musculus	189-193
26840030-8	2016	Reduction in O-GlcNAcylation through intracerebroventricular injection of 6-diazo-5-oxo-l-norleucine (DON), the inhibitor of glutamine fructose-6-phosphate amidotransferase, suppressed PKA-CREB signaling and impaired learning and memory in mice.	Diazooxonorleucine	74-100	cAMP responsive element binding protein 1	Mus musculus	189-193
26840030-8	2016	Reduction in O-GlcNAcylation through intracerebroventricular injection of 6-diazo-5-oxo-l-norleucine (DON), the inhibitor of glutamine fructose-6-phosphate amidotransferase, suppressed PKA-CREB signaling and impaired learning and memory in mice.	Diazooxonorleucine	102-105	cAMP responsive element binding protein 1	Mus musculus	189-193
26840030-9	2016	These results indicate that in addition to cAMP and phosphorylation, O-GlcNAcylation is a novel mechanism that regulates PKA-CREB signaling.	Cyclic AMP	43-47	cAMP responsive element binding protein 1	Mus musculus	125-129
26996316-10	2016	Furthermore, the administration of swertisin significantly increased the phosphorylation levels of hippocampal or cortical protein kinase A (PKA, 5 or 10mg/kg) and CREB (10mg/kg), and co-administration of CPA (0.1mg/kg, i.p) blocked the increased phosphorylated levels of PKA and CREB in the both cortex and hippocampus.	swertisin	35-44	cAMP responsive element binding protein 1	Mus musculus	164-168
26996316-10	2016	Furthermore, the administration of swertisin significantly increased the phosphorylation levels of hippocampal or cortical protein kinase A (PKA, 5 or 10mg/kg) and CREB (10mg/kg), and co-administration of CPA (0.1mg/kg, i.p) blocked the increased phosphorylated levels of PKA and CREB in the both cortex and hippocampus.	swertisin	35-44	cAMP responsive element binding protein 1	Mus musculus	280-284
27252827-10	2016	CONCLUSIONS: Taken together, these findings demonstrate that PF protects diabetic mice against MI at least partially via the TRPV1/CaMK/CREB/CGRP signaling pathway.	peoniflorin	61-63	cAMP responsive element binding protein 1	Mus musculus	136-140
27338163-0	2016	Desipramine improves depression-like behavior and working memory by up-regulating p-CREB in Alzheimer"s disease associated mice.	Desipramine	0-11	cAMP responsive element binding protein 1	Mus musculus	84-88
27284348-0	2016	Allicin inhibits oxidative stress-induced mitochondrial dysfunction and apoptosis by promoting PI3K/AKT and CREB/ERK signaling in osteoblast cells.	allicin	0-7	cAMP responsive element binding protein 1	Mus musculus	108-112
27284348-8	2016	In addition, allicin was demonstrated to be able to significantly ameliorate the repressed phosphoinositide 3-kinase (PI3K)/AKT and cyclic adenosine monophosphate response element-binding protein (CREB)/extracellular-signal-regulated kinase (ERK) signaling pathways by H2O2, which may also be associated with the anti-oxidative stress effects of allicin.	allicin	13-20	cAMP responsive element binding protein 1	Mus musculus	197-201
27284348-8	2016	In addition, allicin was demonstrated to be able to significantly ameliorate the repressed phosphoinositide 3-kinase (PI3K)/AKT and cyclic adenosine monophosphate response element-binding protein (CREB)/extracellular-signal-regulated kinase (ERK) signaling pathways by H2O2, which may also be associated with the anti-oxidative stress effects of allicin.	Hydrogen Peroxide	269-273	cAMP responsive element binding protein 1	Mus musculus	197-201
27284348-8	2016	In addition, allicin was demonstrated to be able to significantly ameliorate the repressed phosphoinositide 3-kinase (PI3K)/AKT and cyclic adenosine monophosphate response element-binding protein (CREB)/extracellular-signal-regulated kinase (ERK) signaling pathways by H2O2, which may also be associated with the anti-oxidative stress effects of allicin.	allicin	346-353	cAMP responsive element binding protein 1	Mus musculus	197-201
27284348-9	2016	In conclusion, allicin protects osteoblasts from H2O2-induced oxidative stress and apoptosis in MC3T3-E1 cells by improving mitochondrial function and the activation of PI3K/AKT and CREB/ERK signaling.	allicin	15-22	cAMP responsive element binding protein 1	Mus musculus	182-186
26453611-7	2016	In a renal proximal tubule cell line, either pharmacologic or genetic inhibition of EGFR, Akt, or CREB blunted YAP expression in response to high-glucose treatment.	Glucose	146-153	cAMP responsive element binding protein 1	Mus musculus	98-102
27338163-8	2016	The neuroprotection of desipramine may be involved in the up-regulation of p-CREB level in the hippocampus of mice.	Desipramine	23-34	cAMP responsive element binding protein 1	Mus musculus	77-81
25969347-3	2016	Exposure of cells to 0.5 muM arsenic increased CRE and c-Fos promoter activities that were accompanied by increases in p38alpha MAPK and CREB phosphorylation and expression levels concurrently with AP-1 activation.	Arsenic	29-36	cAMP responsive element binding protein 1	Mus musculus	137-141
23913855-10	2016	Furthermore, biochemical analysis indicated that short phenamil treatment of cells was accompanied by upregulation in protein expression of integrin alpha5, p125(FAK) and phosphorylation of CREB.	phenylamil	55-63	cAMP responsive element binding protein 1	Mus musculus	190-194
26997033-7	2016	Also, the subchronic treatment with spinosin (5mg/kg) increased the expression levels of phosphorylated extracellular-regulated kinase (ERK), phosphorylated cAMP response element-binding protein (CREB) and mature brain-derived neurotrophic factor (mBDNF) in the hippocampus.	spinosin	36-44	cAMP responsive element binding protein 1	Mus musculus	157-194
26997033-7	2016	Also, the subchronic treatment with spinosin (5mg/kg) increased the expression levels of phosphorylated extracellular-regulated kinase (ERK), phosphorylated cAMP response element-binding protein (CREB) and mature brain-derived neurotrophic factor (mBDNF) in the hippocampus.	spinosin	36-44	cAMP responsive element binding protein 1	Mus musculus	196-200
26997033-8	2016	These findings demonstrate that spinosin has the potential for therapeutic use in treating the cognitive dysfunction observed in neurological or psychiatric disorders by up-regulating adult hippocampal neurogenesis or activating of the ERK-CREB-BDNF signaling pathway.	spinosin	32-40	cAMP responsive element binding protein 1	Mus musculus	240-244
26686692-11	2016	MbetaCD and Cav-1 siRNA knockdown increased OM-induced AMPK, Akt, GSK3beta, and CREB phosphorylation, which were reversed by Ara-A, a specific AMPK inhibitor.	methyl-beta-cyclodextrin	0-7	cAMP responsive element binding protein 1	Mus musculus	80-84
26686692-11	2016	MbetaCD and Cav-1 siRNA knockdown increased OM-induced AMPK, Akt, GSK3beta, and CREB phosphorylation, which were reversed by Ara-A, a specific AMPK inhibitor.	Vidarabine	125-130	cAMP responsive element binding protein 1	Mus musculus	80-84
26880229-3	2016	The study was performed in a novel bitransgenic mouse in which a constitutively active CREB, VP16-CREB, was targeted to astrocytes with the Tet-Off system.	tetramethylenedisulfotetramine	140-143	cAMP responsive element binding protein 1	Mus musculus	87-91
26880229-3	2016	The study was performed in a novel bitransgenic mouse in which a constitutively active CREB, VP16-CREB, was targeted to astrocytes with the Tet-Off system.	tetramethylenedisulfotetramine	140-143	cAMP responsive element binding protein 1	Mus musculus	98-102
25969347-5	2016	CREB phosphorylation and AP-1 activation were decreased in p38alpha knockdown cells after arsenic treatment.	Arsenic	90-97	cAMP responsive element binding protein 1	Mus musculus	0-4
25969347-6	2016	Arsenic-induced AP-1 activation, measured as c-Fos and CRE promoter activities, and CREB phosphorylation were attenuated by p38 inhibition in BALB/c 3T3 cells.	Arsenic	0-7	cAMP responsive element binding protein 1	Mus musculus	84-88
25969347-7	2016	Thus, p38alpha MAPK activation is required for arsenic-induced neoplastic transformation mediated through CREB phosphorylation and AP-1 activation.	Arsenic	47-54	cAMP responsive element binding protein 1	Mus musculus	106-110
26776303-1	2016	The dual leucine zipper kinase DLK induces beta-cell apoptosis by inhibiting the transcriptional activity conferred by the beta-cell protective transcription factor cAMP response element binding protein CREB.	Cyclic AMP	165-169	cAMP responsive element binding protein 1	Mus musculus	203-207
27129593-3	2016	Since activation of cAMP response element binding protein (CREB) plays a crucial role in synaptic strengthening and memory formation, we retooled a clinical drug with known neuroprotective and anti-inflammatory activity to activate CREB, and validated this novel multifunctional drug, NMZ, in 4 different mouse models of AD.	(2s)-4-Amino-N-{(1r,2s,3r,4r,5s)-5-Amino-3-{[3-O-(2,6-Diamino-2,6-Dideoxy-Beta-L-Idopyranosyl)-Beta-D-Ribofuranosyl]oxy}-4-[(2,6-Diamino-2,4,6-Trideoxy-4-Fluoro-Alpha-D-Galactopyranosyl)oxy]-2-Hydroxycyclohexyl}-2-Hydroxybutanamide	285-288	cAMP responsive element binding protein 1	Mus musculus	20-57
27129593-3	2016	Since activation of cAMP response element binding protein (CREB) plays a crucial role in synaptic strengthening and memory formation, we retooled a clinical drug with known neuroprotective and anti-inflammatory activity to activate CREB, and validated this novel multifunctional drug, NMZ, in 4 different mouse models of AD.	(2s)-4-Amino-N-{(1r,2s,3r,4r,5s)-5-Amino-3-{[3-O-(2,6-Diamino-2,6-Dideoxy-Beta-L-Idopyranosyl)-Beta-D-Ribofuranosyl]oxy}-4-[(2,6-Diamino-2,4,6-Trideoxy-4-Fluoro-Alpha-D-Galactopyranosyl)oxy]-2-Hydroxycyclohexyl}-2-Hydroxybutanamide	285-288	cAMP responsive element binding protein 1	Mus musculus	59-63
27129593-3	2016	Since activation of cAMP response element binding protein (CREB) plays a crucial role in synaptic strengthening and memory formation, we retooled a clinical drug with known neuroprotective and anti-inflammatory activity to activate CREB, and validated this novel multifunctional drug, NMZ, in 4 different mouse models of AD.	(2s)-4-Amino-N-{(1r,2s,3r,4r,5s)-5-Amino-3-{[3-O-(2,6-Diamino-2,6-Dideoxy-Beta-L-Idopyranosyl)-Beta-D-Ribofuranosyl]oxy}-4-[(2,6-Diamino-2,4,6-Trideoxy-4-Fluoro-Alpha-D-Galactopyranosyl)oxy]-2-Hydroxycyclohexyl}-2-Hydroxybutanamide	285-288	cAMP responsive element binding protein 1	Mus musculus	232-236
26980711-10	2016	These findings suggest that resveratrol reversing Abeta-induced learning and memory disorder may involve the regulation of neuronal inflammation and apoptosis via PDE4 subtypes related cAMP-CREB-BDNF signaling.	Resveratrol	28-39	cAMP responsive element binding protein 1	Mus musculus	190-194
26980711-10	2016	These findings suggest that resveratrol reversing Abeta-induced learning and memory disorder may involve the regulation of neuronal inflammation and apoptosis via PDE4 subtypes related cAMP-CREB-BDNF signaling.	Cyclic AMP	185-189	cAMP responsive element binding protein 1	Mus musculus	190-194
26519752-5	2016	Furthermore, we discussed whether NR2B (N-methyl-D-aspartate receptor 2B subunit)-CREB (cAMP-response element binding protein) signaling pathway was involved in this course.	Cyclic AMP	88-92	cAMP responsive element binding protein 1	Mus musculus	82-86
26719366-7	2016	Furthermore, SS-31 inhibited expression of transforming-growth factor (TGF)-beta1, Nox4, and thioredoxin-interacting protein (TXNIP), as well as activation of p38 MAPK and CREB and NADPH oxidase activity in diabetic kidneys.	arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide	13-18	cAMP responsive element binding protein 1	Mus musculus	172-176
26762765-1	2016	In this study, we show that reduction of glucose concentration increases TR4 expression in 3T3-L1 cells via stimulation of the GSK-3beta-CREB pathway.	Glucose	41-48	cAMP responsive element binding protein 1	Mus musculus	137-141
26762765-3	2016	In addition, CREB enhanced murine TR4 promoter activity via direct binding to a cAMP response element located in the promoter, and this CREB effect was further strengthened by GSK-3beta.	Cyclic AMP	80-84	cAMP responsive element binding protein 1	Mus musculus	13-17
26762765-3	2016	In addition, CREB enhanced murine TR4 promoter activity via direct binding to a cAMP response element located in the promoter, and this CREB effect was further strengthened by GSK-3beta.	Cyclic AMP	80-84	cAMP responsive element binding protein 1	Mus musculus	136-140
26607269-10	2016	Activation of the PAR1/CREB pathway contributes to the upregulation of DKK1 via OSS.	OSS	80-83	cAMP responsive element binding protein 1	Mus musculus	23-27
26818679-2	2016	The cAMP-dependent transcription factors cAMP-responsive element binding protein (CREB) and cAMP-responsive element modulator (CREM) mediate transcriptional regulation in response to beta-adrenergic stimulation and CREM repressor isoforms are induced after stimulation of the beta-adrenoceptor.	Cyclic AMP	4-8	cAMP responsive element binding protein 1	Mus musculus	41-80
26818679-2	2016	The cAMP-dependent transcription factors cAMP-responsive element binding protein (CREB) and cAMP-responsive element modulator (CREM) mediate transcriptional regulation in response to beta-adrenergic stimulation and CREM repressor isoforms are induced after stimulation of the beta-adrenoceptor.	Cyclic AMP	4-8	cAMP responsive element binding protein 1	Mus musculus	82-86
25388276-0	2016	Rescuing prefrontal cAMP-CREB pathway reverses working memory deficits during withdrawal from prolonged alcohol exposure.	Cyclic AMP	20-24	cAMP responsive element binding protein 1	Mus musculus	25-29
25388276-0	2016	Rescuing prefrontal cAMP-CREB pathway reverses working memory deficits during withdrawal from prolonged alcohol exposure.	Alcohols	104-111	cAMP responsive element binding protein 1	Mus musculus	25-29
26519752-12	2016	Melatonin pretreatment ameliorated disturbed sleep-wake cycle, improved isoflurane-induced cognitive dysfunction, and reversed the down-regulation of CREB and NR2B expression.	Melatonin	0-9	cAMP responsive element binding protein 1	Mus musculus	150-154
25520005-6	2016	We also identify that salidroside targets CREB transcription for the survival of new neurons in the dentate gyrus of old mice.	rhodioloside	22-33	cAMP responsive element binding protein 1	Mus musculus	42-46
25388276-2	2016	A candidate signaling cascade contributing to memory deficits during alcohol withdrawal is the protein kinase A (PKA)/cAMP-responsive element binding (CREB) cascade, although the role of PKA/CREB cascade in behavioral and molecular changes during sustained withdrawal period remains largely unknown.	Alcohols	69-76	cAMP responsive element binding protein 1	Mus musculus	151-155
25388276-2	2016	A candidate signaling cascade contributing to memory deficits during alcohol withdrawal is the protein kinase A (PKA)/cAMP-responsive element binding (CREB) cascade, although the role of PKA/CREB cascade in behavioral and molecular changes during sustained withdrawal period remains largely unknown.	Cyclic AMP	118-122	cAMP responsive element binding protein 1	Mus musculus	151-155
25388276-5	2016	Next, we showed that enhancing CREB activity through rolipram administration prior to testing improved WM performance in withdrawn mice but impaired WM function in water mice.	Rolipram	53-61	cAMP responsive element binding protein 1	Mus musculus	31-35
25388276-5	2016	Next, we showed that enhancing CREB activity through rolipram administration prior to testing improved WM performance in withdrawn mice but impaired WM function in water mice.	Water	164-169	cAMP responsive element binding protein 1	Mus musculus	31-35
25388276-9	2016	Collectively, these results provide strong support that dysregulation of PKA/CREB-dependent processes in prefrontal neurons is a critical molecular signature underlying cognitive decline during alcohol withdrawal.	Alcohols	194-201	cAMP responsive element binding protein 1	Mus musculus	77-81
26515688-4	2016	Furthermore, within the dopaminergic neurons of the substantia nigra in MPTP-treated mice, JNK2/3 phosphorylates threonine 69 (Thr69) of Activating transcription factor-2 (ATF2), a transcription factor of the ATF/CREB family, whereas the phosphorylation of Thr71 is constitutive and remains unchanged.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	72-76	cAMP responsive element binding protein 1	Mus musculus	213-217
26515688-4	2016	Furthermore, within the dopaminergic neurons of the substantia nigra in MPTP-treated mice, JNK2/3 phosphorylates threonine 69 (Thr69) of Activating transcription factor-2 (ATF2), a transcription factor of the ATF/CREB family, whereas the phosphorylation of Thr71 is constitutive and remains unchanged.	Threonine	113-122	cAMP responsive element binding protein 1	Mus musculus	213-217
26892516-7	2016	Additionally, PKA and CREB phosphorylation were observed after 1-hour incubation with TUDCA.	ursodoxicoltaurine	86-91	cAMP responsive element binding protein 1	Mus musculus	22-26
25520005-7	2016	Thus, salidroside is therapeutically effective against learning and memory decays via stimulation of CREB-dependent functional neurogenesis in aging.	rhodioloside	6-17	cAMP responsive element binding protein 1	Mus musculus	101-105
26818512-7	2016	Furthermore, hippocampal ERK2 and CREB phosphorylation in seipin-nKO mice were reduced and this could be rescued by rosi treatment.	Rosiglitazone	116-120	cAMP responsive element binding protein 1	Mus musculus	34-38
26453962-11	2016	Therefore, D-Ala2-GIP-glu-PAL promotes cell survival of dopaminergic neuron in the SNpc by activating the cAMP/PKA/CREB growth factor second messenger pathway that also inhibits apoptosis.	Glutamic Acid	22-25	cAMP responsive element binding protein 1	Mus musculus	115-119
26453962-11	2016	Therefore, D-Ala2-GIP-glu-PAL promotes cell survival of dopaminergic neuron in the SNpc by activating the cAMP/PKA/CREB growth factor second messenger pathway that also inhibits apoptosis.	Cyclic AMP	106-110	cAMP responsive element binding protein 1	Mus musculus	115-119
26780350-8	2016	The administration of erucic acid increased the phosphorylation levels of phosphatidylinositide 3-kinase (PI3K), protein kinase C zeta (PKCzeta), extracellular signal-regulated kinase (ERK), cAMP response element-binding protein (CREB) and additional protein kinase B (Akt) in the hippocampus.	erucic acid	22-33	cAMP responsive element binding protein 1	Mus musculus	191-228
26780350-8	2016	The administration of erucic acid increased the phosphorylation levels of phosphatidylinositide 3-kinase (PI3K), protein kinase C zeta (PKCzeta), extracellular signal-regulated kinase (ERK), cAMP response element-binding protein (CREB) and additional protein kinase B (Akt) in the hippocampus.	erucic acid	22-33	cAMP responsive element binding protein 1	Mus musculus	230-234
26780350-9	2016	These results suggest that erucic acid has an ameliorative effect in mice with scopolamine-induced memory deficits and that the effect of erucic acid is partially due to the activation of PI3K-PKCzeta-ERK-CREB signaling as well as an increase in phosphorylated Akt in the hippocampus.	Scopolamine	79-90	cAMP responsive element binding protein 1	Mus musculus	205-209
26780350-9	2016	These results suggest that erucic acid has an ameliorative effect in mice with scopolamine-induced memory deficits and that the effect of erucic acid is partially due to the activation of PI3K-PKCzeta-ERK-CREB signaling as well as an increase in phosphorylated Akt in the hippocampus.	erucic acid	138-149	cAMP responsive element binding protein 1	Mus musculus	205-209
26608789-2	2016	Vasopressin, one of the effector hormones of the renin-angiotensin system (RAS) via the type 2-receptor (V2R), activates the cAMP/PKA/cAMP response element-binding protein (CREB) pathway and aquaporin-2 expression in principal cells of the CD.	Cyclic AMP	125-129	cAMP responsive element binding protein 1	Mus musculus	173-177
26608789-2	2016	Vasopressin, one of the effector hormones of the renin-angiotensin system (RAS) via the type 2-receptor (V2R), activates the cAMP/PKA/cAMP response element-binding protein (CREB) pathway and aquaporin-2 expression in principal cells of the CD.	Cadmium	240-242	cAMP responsive element binding protein 1	Mus musculus	173-177
26608789-10	2016	These results indicate that in the CD the activation of the V2R stimulates renin synthesis via the PKA/CREB pathway independently of RAS, suggesting a critical role for vasopressin in the regulation of renin in the CD.	Cadmium	35-37	cAMP responsive element binding protein 1	Mus musculus	103-107
26863436-10	2016	The neuroprotective effects were mediated by activation of the GLP-1R through the cAMP-PKA-CREB signaling pathway.	Cyclic AMP	82-86	cAMP responsive element binding protein 1	Mus musculus	91-95
26791996-7	2016	Drug treatment significantly increased brain-derived neurotrophic factor (BDNF) and cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) gene expression levels compared to control levels.	Cyclic AMP	84-114	cAMP responsive element binding protein 1	Mus musculus	156-160
26791996-7	2016	Drug treatment significantly increased brain-derived neurotrophic factor (BDNF) and cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) gene expression levels compared to control levels.	Cyclic AMP	116-120	cAMP responsive element binding protein 1	Mus musculus	156-160
26827641-0	2016	Dl-3-n-butylphthalide-induced upregulation of antioxidant defense is involved in the enhancement of cross talk between CREB and Nrf2 in an Alzheimer"s disease mouse model.	3-n-butylphthalide	0-21	cAMP responsive element binding protein 1	Mus musculus	119-123
26827641-7	2016	Dl-NBP administration caused an increase of cyclic adenosine monophosphate-response element binding protein (CREB)-binding protein (CBP)-associated Ser133-phosphorylated CREB (p-CREB) protein.	3-n-butylphthalide	0-6	cAMP responsive element binding protein 1	Mus musculus	44-107
26827641-7	2016	Dl-NBP administration caused an increase of cyclic adenosine monophosphate-response element binding protein (CREB)-binding protein (CBP)-associated Ser133-phosphorylated CREB (p-CREB) protein.	3-n-butylphthalide	0-6	cAMP responsive element binding protein 1	Mus musculus	109-113
26827641-7	2016	Dl-NBP administration caused an increase of cyclic adenosine monophosphate-response element binding protein (CREB)-binding protein (CBP)-associated Ser133-phosphorylated CREB (p-CREB) protein.	3-n-butylphthalide	0-6	cAMP responsive element binding protein 1	Mus musculus	170-174
26827641-9	2016	We demonstrate that the Dl-NBP-triggered upregulation of antioxidant defenses is involved in the enhancement of cross talk between CREB and nuclear factor erythroid 2-related factor 2 via CBP.	3-n-butylphthalide	24-30	cAMP responsive element binding protein 1	Mus musculus	131-135
26525565-8	2016	Bay 60-7550 (3 mg/kg) enhanced phosphorylation of CREB and VASP, both targets of cGMP-dependent protein kinase (PKG).	2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one	0-11	cAMP responsive element binding protein 1	Mus musculus	50-54
26818512-14	2016	The PPARgamma agonist rosiglitazone can ameliorate spatial cognitive deficits and rescue the LTP induction in seipin knock-out mice by restoring AMPA receptor expression and ERK-CREB activities.	Rosiglitazone	22-35	cAMP responsive element binding protein 1	Mus musculus	178-182
26497104-11	2016	The present study has shown that BE360 has antidepressant and antidementia effects characterized by hippocampal cell proliferation potentially activated via CREB/BDNF signaling pathways.	be360	33-38	cAMP responsive element binding protein 1	Mus musculus	157-161
26739966-6	2016	Dexamethasone treatment of AtT20 cells decreased forskolin stimulation of c-Fos, Nr4a1 and phosphorylated CREB expression, effects that were mimicked by overexpression of Rasd1, and inhibited by knockdown of Rasd1.	Dexamethasone	0-13	cAMP responsive element binding protein 1	Mus musculus	106-110
26621343-5	2016	Furthermore, the hepatic increases in gluconeogenic gene expression in HFD/STZ mice was significantly reduced by evogliptin treatment, which was accompanied by the suppression of cAMP response element-binding protein (CREB) phosphorylation and expression of transducer of regulated CREB protein 2.	Streptozocin	75-78	cAMP responsive element binding protein 1	Mus musculus	218-222
26621343-5	2016	Furthermore, the hepatic increases in gluconeogenic gene expression in HFD/STZ mice was significantly reduced by evogliptin treatment, which was accompanied by the suppression of cAMP response element-binding protein (CREB) phosphorylation and expression of transducer of regulated CREB protein 2.	4-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(tert-butoxymethyl)piperazin-2-one	113-123	cAMP responsive element binding protein 1	Mus musculus	179-216
26621343-5	2016	Furthermore, the hepatic increases in gluconeogenic gene expression in HFD/STZ mice was significantly reduced by evogliptin treatment, which was accompanied by the suppression of cAMP response element-binding protein (CREB) phosphorylation and expression of transducer of regulated CREB protein 2.	4-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(tert-butoxymethyl)piperazin-2-one	113-123	cAMP responsive element binding protein 1	Mus musculus	218-222
26621343-5	2016	Furthermore, the hepatic increases in gluconeogenic gene expression in HFD/STZ mice was significantly reduced by evogliptin treatment, which was accompanied by the suppression of cAMP response element-binding protein (CREB) phosphorylation and expression of transducer of regulated CREB protein 2.	4-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-3-(tert-butoxymethyl)piperazin-2-one	113-123	cAMP responsive element binding protein 1	Mus musculus	282-286
26620557-5	2016	We demonstrate that stimulation of GPR17 by the small molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin basic protein expression levels mainly by triggering the Galphai/o signaling pathway, which in turn leads to reduced activity of the downstream cascade adenylyl cyclase-cAMP-PKA-cAMP response element-binding protein (CREB).	2-carboxy-4,6-dichloro-1h-indole-3-propionic acid	82-131	cAMP responsive element binding protein 1	Mus musculus	367-371
26739966-6	2016	Dexamethasone treatment of AtT20 cells decreased forskolin stimulation of c-Fos, Nr4a1 and phosphorylated CREB expression, effects that were mimicked by overexpression of Rasd1, and inhibited by knockdown of Rasd1.	Colforsin	49-58	cAMP responsive element binding protein 1	Mus musculus	106-110
26658370-0	2016	Antinociception of spirocyclopiperazinium salt compound LXM-10-M targeting alpha7 nicotinic receptor and M4 muscarinic receptor and inhibiting CaMKIIalpha/CREB/CGRP signaling pathway in mice.	spirocyclopiperazinium salt	19-46	cAMP responsive element binding protein 1	Mus musculus	155-159
26607348-0	2016	Puerarin protects mouse liver against nickel-induced oxidative stress and inflammation associated with the TLR4/p38/CREB pathway.	puerarin	0-8	cAMP responsive element binding protein 1	Mus musculus	116-120
26607348-0	2016	Puerarin protects mouse liver against nickel-induced oxidative stress and inflammation associated with the TLR4/p38/CREB pathway.	Nickel	38-44	cAMP responsive element binding protein 1	Mus musculus	116-120
26607348-9	2016	Likewise, Ni-induced inflammatory responses were diminished by puerarin as observed by a remarkable reduction in the levels of phosphorylated CREB.	puerarin	63-71	cAMP responsive element binding protein 1	Mus musculus	142-146
26607348-11	2016	Data from this study suggested that the inhibition of Ni-induced oxidative stress and inflammatory responses by puerarin is due to its ability to modulate the TLR4/p38/CREB signaling pathway.	puerarin	112-120	cAMP responsive element binding protein 1	Mus musculus	168-172
26658370-0	2016	Antinociception of spirocyclopiperazinium salt compound LXM-10-M targeting alpha7 nicotinic receptor and M4 muscarinic receptor and inhibiting CaMKIIalpha/CREB/CGRP signaling pathway in mice.	[(3~{S},3~{a}~{S},8~{b}~{S})-3-(hydroxymethyl)-2,3,3~{a},8~{b}-tetrahydro-[1]benzofuro[3,2-b]pyrrol-1-yl]-phenyl-methanone	56-59	cAMP responsive element binding protein 1	Mus musculus	155-159
26658370-3	2016	The possible changes of calcium/calmodulin-dependent protein kinase IIalpha (CaMKIIalpha)/cAMP response element-binding protein (CREB)/calcitonin gene related peptide (CGRP) signaling pathway were detected by Western Blot in mice.	Cyclic AMP	90-94	cAMP responsive element binding protein 1	Mus musculus	129-133
26658370-7	2016	This is the first paper to report that LXM-10-M exerted significant antinociception, which may be attributed to the activation of alpha7 nicotinic receptor and M4 muscarinic receptor and thereby triggering the inhibition of CaMKIIalpha/CREB/CGRP signaling pathway in mice.	[(3~{S},3~{a}~{S},8~{b}~{S})-3-(hydroxymethyl)-2,3,3~{a},8~{b}-tetrahydro-[1]benzofuro[3,2-b]pyrrol-1-yl]-phenyl-methanone	39-42	cAMP responsive element binding protein 1	Mus musculus	236-240
25520004-10	2016	AR inhibition caused 4-hydroxynonenal (HNE) accumulation, which induced the phosphorylation of the cAMP response element-binding protein (CREB) to promote Arg1 expression.	4-hydroxy-2-nonenal	21-37	cAMP responsive element binding protein 1	Mus musculus	99-136
26358273-0	2016	S100A4 gene silencing in oxygen-induced ischemic retinopathy inhibits retinal neovascularization via down-regulation of CREB expression.	Oxygen	25-31	cAMP responsive element binding protein 1	Mus musculus	120-124
25520004-10	2016	AR inhibition caused 4-hydroxynonenal (HNE) accumulation, which induced the phosphorylation of the cAMP response element-binding protein (CREB) to promote Arg1 expression.	4-hydroxy-2-nonenal	21-37	cAMP responsive element binding protein 1	Mus musculus	138-142
25520004-10	2016	AR inhibition caused 4-hydroxynonenal (HNE) accumulation, which induced the phosphorylation of the cAMP response element-binding protein (CREB) to promote Arg1 expression.	4-hydroxy-2-nonenal	39-42	cAMP responsive element binding protein 1	Mus musculus	99-136
25428621-0	2016	Mdivi-1 Protects Against Ischemic Brain Injury via Elevating Extracellular Adenosine in a cAMP/CREB-CD39-Dependent Manner.	Adenosine	75-84	cAMP responsive element binding protein 1	Mus musculus	95-99
25520004-10	2016	AR inhibition caused 4-hydroxynonenal (HNE) accumulation, which induced the phosphorylation of the cAMP response element-binding protein (CREB) to promote Arg1 expression.	4-hydroxy-2-nonenal	39-42	cAMP responsive element binding protein 1	Mus musculus	138-142
25428621-10	2016	Our results demonstrate that Mdivi-1 protects against ischemic brain injury through increasing extracellular adenosine, a process involving elevated CD39 expression that is likely modulated by cAMP/PKA/CREB cascade.	Cyclic AMP	193-197	cAMP responsive element binding protein 1	Mus musculus	202-206
25428621-12	2016	Results from the present study indicate that Mdivi-1 protects against ischemic brain injury through increasing extracellular adenosine, a process involving elevated CD39 expression that is likely modulated by the cAMP/PKA/CREB cascades.	Cyclic AMP	213-217	cAMP responsive element binding protein 1	Mus musculus	222-226
25520004-11	2016	KG501, the specific inhibitor of phosphorylated CREB, could cancel the upregulation of Arg1 by ARI or HNE stimulation.	naphthol AS-E phosphate	0-5	cAMP responsive element binding protein 1	Mus musculus	48-52
27242917-10	2016	MHY498 suppressed UVB-induced melanogenesis by inhibiting phosphorylation of CREB and translocation of MITF protein into the nucleus, which are key factors for tyrosinase expression.	(Z)-5-(2,4-dihydroxybenzylidene)thiazolidine-2,4-dione	0-6	cAMP responsive element binding protein 1	Mus musculus	77-81
26694325-9	2015	Delphinidin prevented VEGF-induced phosphorylation of ERK1/2 and p38 MAPK and decreased the expression of the transcription factors, CREB and ATF1.	delphinidin	0-11	cAMP responsive element binding protein 1	Mus musculus	133-137
26670281-4	2015	We showed that a 3-week chronic free-choice ethanol consumption in C57BL/6J mice led to a decrease in DNA methylation of the Bdnf gene within the CA1 and CA3 subfields of the hippocampus, and upregulated hippocampal BDNF signaling pathways mediated by ERK, AKT and CREB.	Ethanol	44-51	cAMP responsive element binding protein 1	Mus musculus	265-269
26453932-11	2015	Blockade of ERK1/2 activation with PD198306 blocked the DJS-induced activation of the ERK1/2/CREB/BDNF cascade and LTP enhancement.	PD 198306	35-43	cAMP responsive element binding protein 1	Mus musculus	93-97
26419901-3	2015	The activity of cyclic AMP (cAMP) response element-binding protein (CREB), a major transcription factor promoting CRE-mediated transcription, increases following a prolonged seizure called status epilepticus.	Cyclic AMP	16-26	cAMP responsive element binding protein 1	Mus musculus	68-72
26485503-0	2015	Resveratrol abrogates lipopolysaccharide-induced depressive-like behavior, neuroinflammatory response, and CREB/BDNF signaling in mice.	Resveratrol	0-11	cAMP responsive element binding protein 1	Mus musculus	107-111
26408985-10	2015	Moreover, Pal-5HT suppressed the death of neuronal cells in CA1 and CA3 regions, while it restored expression of p-CREB and BDNF in hippocampus.	pal-5ht	10-17	cAMP responsive element binding protein 1	Mus musculus	115-119
26408985-11	2015	Taken together, Pal-5HT is suggested to ameliorate deficits of memory and learning through regulation of cholinergic function, activation of antioxidant systems as well as restoration of BDNF and p-CREB expression.	pal-5ht	16-23	cAMP responsive element binding protein 1	Mus musculus	198-202
26419901-3	2015	The activity of cyclic AMP (cAMP) response element-binding protein (CREB), a major transcription factor promoting CRE-mediated transcription, increases following a prolonged seizure called status epilepticus.	Cyclic AMP	28-32	cAMP responsive element binding protein 1	Mus musculus	68-72
26844205-2	2016	Our objectives were to test the hypothesis that the proposed CREB/CRTC2 inhibitor salt inducible kinase 1 (SIK1) contributes to whole body glucose homeostasis in vivo by regulating hepatic transcription of gluconeogenic genes and also to identify novel SIK1 actions on glucose metabolism.	Glucose	139-146	cAMP responsive element binding protein 1	Mus musculus	61-65
26481532-4	2015	OBJECTIVE AND METHODS: In the present study we investigated whether acute or chronic treatment with imipramine, escitalopram, reboxetine and bupropion would cause changes in CREB, BDNF, TrkB and GPR39-Zn(2+) receptor proteins (measured by Western Blot) in the frontal cortex of mice fed with a low-zinc diet.	Imipramine	100-110	cAMP responsive element binding protein 1	Mus musculus	174-178
26481532-4	2015	OBJECTIVE AND METHODS: In the present study we investigated whether acute or chronic treatment with imipramine, escitalopram, reboxetine and bupropion would cause changes in CREB, BDNF, TrkB and GPR39-Zn(2+) receptor proteins (measured by Western Blot) in the frontal cortex of mice fed with a low-zinc diet.	Citalopram	112-124	cAMP responsive element binding protein 1	Mus musculus	174-178
26481532-4	2015	OBJECTIVE AND METHODS: In the present study we investigated whether acute or chronic treatment with imipramine, escitalopram, reboxetine and bupropion would cause changes in CREB, BDNF, TrkB and GPR39-Zn(2+) receptor proteins (measured by Western Blot) in the frontal cortex of mice fed with a low-zinc diet.	Reboxetine	126-136	cAMP responsive element binding protein 1	Mus musculus	174-178
26481532-4	2015	OBJECTIVE AND METHODS: In the present study we investigated whether acute or chronic treatment with imipramine, escitalopram, reboxetine and bupropion would cause changes in CREB, BDNF, TrkB and GPR39-Zn(2+) receptor proteins (measured by Western Blot) in the frontal cortex of mice fed with a low-zinc diet.	Bupropion	141-150	cAMP responsive element binding protein 1	Mus musculus	174-178
26627259-6	2015	We also show that the reported corticosterone extraproduction during the RF active phase reflects an adrenal aberrant activation of CREB signaling, which selectively delays the activation of the PPARalpha-RevErbalpha axis in muscle and heart and accounts for the retarded shift of their PCCs.	Corticosterone	31-45	cAMP responsive element binding protein 1	Mus musculus	132-136
26377646-5	2015	Western analysis of cAMP-activated protein kinase A (PKA) target proteins identified ATR-mediated concentration-dependent alterations in phosphorylation including phospho-CREB.	Cyclic AMP	20-24	cAMP responsive element binding protein 1	Mus musculus	171-175
26635527-8	2015	Glutamatergic signaling is further compromised through downregulation of CamKII and its secondary and tertiary messengers resulting in reduced cAMP response element-binding (CREB) signaling.	Cyclic AMP	143-147	cAMP responsive element binding protein 1	Mus musculus	174-178
26301823-0	2015	CIH-induced neurocognitive impairments are associated with hippocampal Ca(2+) overload, apoptosis, and dephosphorylation of ERK1/2 and CREB that are mediated by overactivation of NMDARs.	cih	0-3	cAMP responsive element binding protein 1	Mus musculus	135-139
26527454-7	2015	The contents of hippocampal cAMP response element binding protein (CREB), phosphorylated CREB, synapsin I, and cAMP were decreased in an age-dependent manner, and the most substantial decrease occurred in old mice treated with ZnO NPs.	Zinc Oxide	227-230	cAMP responsive element binding protein 1	Mus musculus	28-65
26527454-9	2015	One of the mechanisms might due to the supression of cAMP/CREB signaling.	Cyclic AMP	53-57	cAMP responsive element binding protein 1	Mus musculus	58-62
26301823-7	2015	Increased caspase expression in hippocampus was observed in CIH mice associated with significant elevation of [Ca(2+)]i and dephosphorylation of ERK and CREB expression.	cih	60-63	cAMP responsive element binding protein 1	Mus musculus	153-157
26301823-9	2015	Our study suggests that overactivation of NMDARs and the Ca(2+) overload-dependent ERK/CREB dysregulation is one of the important mechanisms in mediating the CIH-induced neurocognitive impairments.	cih	158-161	cAMP responsive element binding protein 1	Mus musculus	87-91
26348574-6	2015	By contrast, the induction of ID1 by prostaglandin E2 was mediated by cAMP response element-binding protein (CREB).	Dinoprostone	37-53	cAMP responsive element binding protein 1	Mus musculus	70-107
26348574-6	2015	By contrast, the induction of ID1 by prostaglandin E2 was mediated by cAMP response element-binding protein (CREB).	Dinoprostone	37-53	cAMP responsive element binding protein 1	Mus musculus	109-113
26385876-8	2015	VPA treatment notably improved pSer133-cAMP response element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) levels, which are associated with synaptic function and neurite outgrowth.	Valproic Acid	0-3	cAMP responsive element binding protein 1	Mus musculus	31-76
26385876-8	2015	VPA treatment notably improved pSer133-cAMP response element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) levels, which are associated with synaptic function and neurite outgrowth.	Valproic Acid	0-3	cAMP responsive element binding protein 1	Mus musculus	78-82
26385876-9	2015	CONCLUSION: VPA improves behavioral deficits in AD, modifies synaptic structure, and accelerates neurite outgrowth, by inhibiting the activity of GSK-3beta, decreasing hyperphosphorylated tau, enhancing CREB and BDNF expression.	Valproic Acid	12-15	cAMP responsive element binding protein 1	Mus musculus	203-207
26552350-3	2015	MATERIALS AND METHODS: We created conditional deletion of CREB in mice with low-sodium diet, specifically in renin cells of the kidney.	Sodium	80-86	cAMP responsive element binding protein 1	Mus musculus	58-62
26358750-6	2015	CEBPD is responsive to the hydroxymethyldibenzoylmethane (HMDB)-induced p38/CREB pathway and plays an important role in the HMDB-induced apoptosis of cancer cells.	hydroxymethyldibenzoylmethane	27-56	cAMP responsive element binding protein 1	Mus musculus	76-80
26358750-6	2015	CEBPD is responsive to the hydroxymethyldibenzoylmethane (HMDB)-induced p38/CREB pathway and plays an important role in the HMDB-induced apoptosis of cancer cells.	hmdb	58-62	cAMP responsive element binding protein 1	Mus musculus	76-80
26105003-12	2015	In addition, DT3 treatment decreased phosphorylation of GSK-3, P38, and CREB in murine PDAC.Inhibition of PKG could be a potential therapeutic strategy for PDAC treatment which should be carefully validated in future pre-clinical studies.	dt3	13-16	cAMP responsive element binding protein 1	Mus musculus	72-76
26038580-6	2015	In the liver, a decrease in intracellular cAMP was observed with decreased CREB phosphorylation.	Cyclic AMP	42-46	cAMP responsive element binding protein 1	Mus musculus	75-79
26342077-2	2015	Triggering of the cAMP pathway in hepatocytes stimulates the gluconeogenic program via the PKA-mediated phosphorylation of CREB and dephosphorylation of the cAMP-regulated CREB coactivators CRTC2 and CRTC3.	Cyclic AMP	18-22	cAMP responsive element binding protein 1	Mus musculus	123-127
26342077-2	2015	Triggering of the cAMP pathway in hepatocytes stimulates the gluconeogenic program via the PKA-mediated phosphorylation of CREB and dephosphorylation of the cAMP-regulated CREB coactivators CRTC2 and CRTC3.	Cyclic AMP	18-22	cAMP responsive element binding protein 1	Mus musculus	172-176
26342077-2	2015	Triggering of the cAMP pathway in hepatocytes stimulates the gluconeogenic program via the PKA-mediated phosphorylation of CREB and dephosphorylation of the cAMP-regulated CREB coactivators CRTC2 and CRTC3.	Cyclic AMP	157-161	cAMP responsive element binding protein 1	Mus musculus	172-176
26473849-10	2015	In addition, PCP led to the down-regulation of phospho-p38, phospho-PKA, phospho-CREB, phospho-GSK3beta, MITF, and TRP-1 compared with alpha-MSH-stimulated B16F10 cells.	pcp	13-16	cAMP responsive element binding protein 1	Mus musculus	81-85
26055203-15	2015	In addition, cross state-dependent learning between WIN and ethanol or nicotine was associated with the increase of the hippocampal p-CREB/CREB ratio.	Ethanol	60-67	cAMP responsive element binding protein 1	Mus musculus	134-138
26055203-15	2015	In addition, cross state-dependent learning between WIN and ethanol or nicotine was associated with the increase of the hippocampal p-CREB/CREB ratio.	Ethanol	60-67	cAMP responsive element binding protein 1	Mus musculus	139-143
26055203-15	2015	In addition, cross state-dependent learning between WIN and ethanol or nicotine was associated with the increase of the hippocampal p-CREB/CREB ratio.	Nicotine	71-79	cAMP responsive element binding protein 1	Mus musculus	134-138
26055203-15	2015	In addition, cross state-dependent learning between WIN and ethanol or nicotine was associated with the increase of the hippocampal p-CREB/CREB ratio.	Nicotine	71-79	cAMP responsive element binding protein 1	Mus musculus	139-143
26586997-0	2015	Quercetin-3-O-beta-d-glucopyranosyl-(1   6)-beta-d-glucopyranoside suppresses melanin synthesis by augmenting p38 MAPK and CREB signaling pathways and subsequent cAMP down-regulation in murine melanoma cells.	Melanins	78-85	cAMP responsive element binding protein 1	Mus musculus	123-127
26473849-12	2015	These results suggest that PCP decreases tyrosinase activity and melanin production via inactivation of the p38 and PKA signaling pathways, and subsequently decreases phosphorylation of CREB, MITF, and melanogenic enzymes.	pcp	27-30	cAMP responsive element binding protein 1	Mus musculus	186-190
26055203-9	2015	The hippocampal p-CREB/CREB ratio enhanced in ethanol- and ethanol-nicotine induced STD.	Ethanol	46-53	cAMP responsive element binding protein 1	Mus musculus	18-22
26055203-9	2015	The hippocampal p-CREB/CREB ratio enhanced in ethanol- and ethanol-nicotine induced STD.	Ethanol	46-53	cAMP responsive element binding protein 1	Mus musculus	23-27
26055203-9	2015	The hippocampal p-CREB/CREB ratio enhanced in ethanol- and ethanol-nicotine induced STD.	Ethanol	59-66	cAMP responsive element binding protein 1	Mus musculus	18-22
26055203-9	2015	The hippocampal p-CREB/CREB ratio enhanced in ethanol- and ethanol-nicotine induced STD.	Ethanol	59-66	cAMP responsive element binding protein 1	Mus musculus	23-27
26055203-9	2015	The hippocampal p-CREB/CREB ratio enhanced in ethanol- and ethanol-nicotine induced STD.	Nicotine	67-75	cAMP responsive element binding protein 1	Mus musculus	18-22
26055203-9	2015	The hippocampal p-CREB/CREB ratio enhanced in ethanol- and ethanol-nicotine induced STD.	Nicotine	67-75	cAMP responsive element binding protein 1	Mus musculus	23-27
26601420-0	2015	The DNA methylation inhibitor 5-azacytidine decreases melanin synthesis by inhibiting CREB phosphorylation.	Azacitidine	30-43	cAMP responsive element binding protein 1	Mus musculus	86-90
26352003-0	2015	Dioscin Derived from Solanum melongena L. "Usukawamarunasu" Attenuates alpha-MSH-Induced Melanogenesis in B16 Murine Melanoma Cells via Downregulation of Phospho-CREB and MITF.	dioscin	0-7	cAMP responsive element binding protein 1	Mus musculus	162-166
26352003-4	2015	In addition, dioscin caused reduction of phosphorylated cAMP-responsive element binding protein 1 transcription factors (CREB), which led to a reduction of microphthalmia-related transcription factor (MITF) in alpha-MSH-stimulated cells, but did not affect phosphorylation of extracellular signal-regulated kinase.	dioscin	13-20	cAMP responsive element binding protein 1	Mus musculus	121-125
26352003-4	2015	In addition, dioscin caused reduction of phosphorylated cAMP-responsive element binding protein 1 transcription factors (CREB), which led to a reduction of microphthalmia-related transcription factor (MITF) in alpha-MSH-stimulated cells, but did not affect phosphorylation of extracellular signal-regulated kinase.	Cyclic AMP	56-60	cAMP responsive element binding protein 1	Mus musculus	121-125
26352003-6	2015	These results suggest that dioscin may decrease the level of MITF via inhibition of phosphorylation of CREB in alpha-MSH-induced melanogenesis in B16 cells.	dioscin	27-34	cAMP responsive element binding protein 1	Mus musculus	103-107
25425331-1	2015	Transcription factors of the cAMP response element-binding protein (Creb)/cAMP response element modulator (Crem) family were linked to the switch from a contractile to a proliferating phenotype in vascular smooth muscle cells (VSMCs).	Cyclic AMP	29-33	cAMP responsive element binding protein 1	Mus musculus	68-72
26601420-0	2015	The DNA methylation inhibitor 5-azacytidine decreases melanin synthesis by inhibiting CREB phosphorylation.	Melanins	54-61	cAMP responsive element binding protein 1	Mus musculus	86-90
26601420-8	2015	We found that 5-azacytidine decreased the phosphorylation of CREB.	Azacitidine	14-27	cAMP responsive element binding protein 1	Mus musculus	61-65
26601420-9	2015	Therefore, we propose that 5-azacytidine may decrease melanin synthesis by downregulating MITF and tyrosinase via CREB inactivation.	Azacitidine	27-40	cAMP responsive element binding protein 1	Mus musculus	114-118
26601420-9	2015	Therefore, we propose that 5-azacytidine may decrease melanin synthesis by downregulating MITF and tyrosinase via CREB inactivation.	Melanins	54-61	cAMP responsive element binding protein 1	Mus musculus	114-118
26118414-0	2015	Endogenous prostaglandin E2 potentiates anti-inflammatory phenotype of macrophage through the CREB-C/EBP-beta cascade.	Dinoprostone	11-27	cAMP responsive element binding protein 1	Mus musculus	94-98
26368803-12	2015	Taken together, these results indicated that swimming exercise prevented the impairment of object recognition LTM induced by arsenic exposure, which may be mediated by BDNF and CREB in the dorsal hippocampus.	Arsenic	125-132	cAMP responsive element binding protein 1	Mus musculus	177-181
26118414-4	2015	Of note, PGE2 phosphorylates CREB via EP2 and EP4 receptor ligation, thereby transcriptionally increasing C/EBP-beta expression in BALB/c bone marrow derived macrophages.	Dinoprostone	9-13	cAMP responsive element binding protein 1	Mus musculus	29-33
26322719-8	2015	Furthermore, alpha-iso-cubebenol induced CREB phosphorylation and Nrf-2 nuclear accumulation and increased the promoter activity of ARE and CREB in HT22 cells.	alpha-iso-cubebenol	13-32	cAMP responsive element binding protein 1	Mus musculus	41-45
26322719-8	2015	Furthermore, alpha-iso-cubebenol induced CREB phosphorylation and Nrf-2 nuclear accumulation and increased the promoter activity of ARE and CREB in HT22 cells.	alpha-iso-cubebenol	13-32	cAMP responsive element binding protein 1	Mus musculus	140-144
26322719-10	2015	Subsequent studies revealed that the inhibitory effects of alpha-iso-cubebenol on glutamate-induced apoptosis were abolished by small interfering RNA-mediated knockdown of CREB and Nrf-2.	alpha-iso-cubebenol	59-78	cAMP responsive element binding protein 1	Mus musculus	172-176
26322719-10	2015	Subsequent studies revealed that the inhibitory effects of alpha-iso-cubebenol on glutamate-induced apoptosis were abolished by small interfering RNA-mediated knockdown of CREB and Nrf-2.	Glutamic Acid	82-91	cAMP responsive element binding protein 1	Mus musculus	172-176
26118414-5	2015	Activated CREB directly binds to the CREB-responsive element of the C/EBP-beta promoter, such that PGE2 ultimately reinforces arg1, IL10 and Mrc1 gene expression.	Dinoprostone	99-103	cAMP responsive element binding protein 1	Mus musculus	10-14
26118414-5	2015	Activated CREB directly binds to the CREB-responsive element of the C/EBP-beta promoter, such that PGE2 ultimately reinforces arg1, IL10 and Mrc1 gene expression.	Dinoprostone	99-103	cAMP responsive element binding protein 1	Mus musculus	37-41
26118414-6	2015	Cyclic AMP activator forskolin also phosphorylated CREB and induced the C/EBP-beta cascade, but this was completely blocked by the PKA inhibitor, H89.	Cyclic AMP	0-10	cAMP responsive element binding protein 1	Mus musculus	51-55
26118414-6	2015	Cyclic AMP activator forskolin also phosphorylated CREB and induced the C/EBP-beta cascade, but this was completely blocked by the PKA inhibitor, H89.	Colforsin	21-30	cAMP responsive element binding protein 1	Mus musculus	51-55
26300473-8	2015	METH-induced prolonged increases in Fosb, Fra2, Egr1, and Egr3 mRNA levels in HDAC2KO mice were associated with increased enrichment of phosphorylated CREB (pCREB) on the promoters of these genes.	Methamphetamine	0-4	cAMP responsive element binding protein 1	Mus musculus	151-155
26301810-7	2015	We found that iron negatively regulates leptin transcription via cAMP-responsive element binding protein activation (CREB activation) and identified 2 potential CREB-binding sites in the mouse leptin promoter region.	Iron	14-18	cAMP responsive element binding protein 1	Mus musculus	117-121
26301810-7	2015	We found that iron negatively regulates leptin transcription via cAMP-responsive element binding protein activation (CREB activation) and identified 2 potential CREB-binding sites in the mouse leptin promoter region.	Cyclic AMP	65-69	cAMP responsive element binding protein 1	Mus musculus	117-121
26301810-9	2015	ChIP analysis revealed that binding of phosphorylated CREB is enriched at these two sites in iron-treated 3T3-L1 adipocytes compared with untreated cells.	Iron	93-97	cAMP responsive element binding protein 1	Mus musculus	54-58
26301810-11	2015	These findings indicate that levels of dietary iron play an important role in regulation of appetite and metabolism through CREB-dependent modulation of leptin expression.	Iron	47-51	cAMP responsive element binding protein 1	Mus musculus	124-128
26313266-0	2015	CP-154,526 Modifies CREB Phosphorylation and Thioredoxin-1 Expression in the Dentate Gyrus following Morphine-Induced Conditioned Place Preference.	cp-154	0-6	cAMP responsive element binding protein 1	Mus musculus	20-24
26313266-0	2015	CP-154,526 Modifies CREB Phosphorylation and Thioredoxin-1 Expression in the Dentate Gyrus following Morphine-Induced Conditioned Place Preference.	Morphine	101-109	cAMP responsive element binding protein 1	Mus musculus	20-24
25757752-0	2015	Combined ampakine and BDNF treatments enhance poststroke functional recovery in aged mice via AKT-CREB signaling.	ampakine	9-17	cAMP responsive element binding protein 1	Mus musculus	98-102
26114447-9	2015	Caffeine increased the transformation of ADP to ATP and activated the cAMP/CREB/SIRT3/AMPK/ACC pathway in the liver.	Caffeine	0-8	cAMP responsive element binding protein 1	Mus musculus	75-79
26114447-9	2015	Caffeine increased the transformation of ADP to ATP and activated the cAMP/CREB/SIRT3/AMPK/ACC pathway in the liver.	Cyclic AMP	70-74	cAMP responsive element binding protein 1	Mus musculus	75-79
26114447-12	2015	These results demonstrate that caffeine could improve HED-induced hepatic steatosis by promoting lipid metabolism via the cAMP/CREB/SIRT3/AMPK/ACC pathway.	Caffeine	31-39	cAMP responsive element binding protein 1	Mus musculus	127-131
26252217-9	2015	INO-1001 was effective in significantly increasing activated CREB and BDNF in the striatal spiny neurons, which might account for the beneficial effects observed in this model.	INO 1001	0-8	cAMP responsive element binding protein 1	Mus musculus	61-65
26118928-5	2015	Accordingly, simvastatin increases CREB and brain-derived neurotrophic factor (BDNF) in the hippocampus of Ppara null mice receiving full-length lentiviral PPARalpha, but not L331M/Y334D statin-binding domain-mutated lentiviral PPARalpha.	Simvastatin	13-24	cAMP responsive element binding protein 1	Mus musculus	35-39
25858697-6	2015	After 24 hr of Abeta1-42 injection, the mice were treated with melatonin (10 mg/kg, intraperitonially) for 3 wks, reversed the Abeta1-42-induced synaptic disorder via increasing the level of presyanptic (Synaptophysin and SNAP-25) and postsynaptic protein [PSD95, p-GluR1 (Ser845), SNAP23, and p-CREB (Ser133)], respectively, and attenuated the Abeta1-42-induced memory impairment.	Melatonin	63-72	cAMP responsive element binding protein 1	Mus musculus	296-300
26010875-7	2015	CREB (cAMP-response element-binding protein) signaling, Arc and brain-derived neurotrophic factor, which play important roles in synaptic plasticity and adaptive cellular stress responses, were up-regulated in response to DNP, and DNP-treated mice exhibited improved performance in a test of learning and memory.	2,4-Dinitrophenol	222-225	cAMP responsive element binding protein 1	Mus musculus	0-4
26010875-7	2015	CREB (cAMP-response element-binding protein) signaling, Arc and brain-derived neurotrophic factor, which play important roles in synaptic plasticity and adaptive cellular stress responses, were up-regulated in response to DNP, and DNP-treated mice exhibited improved performance in a test of learning and memory.	2,4-Dinitrophenol	222-225	cAMP responsive element binding protein 1	Mus musculus	6-43
26010875-11	2015	Here, we show that the mitochondrial uncoupling agent 2,4-dinitrophenol (DNP) elicits adaptive signaling responses in the cerebral cortex involving activation of Ca(2+) -CREB and autophagy pathways, and inhibition of mTOR and insulin signaling pathways.	2,4-Dinitrophenol	54-71	cAMP responsive element binding protein 1	Mus musculus	170-174
26010875-11	2015	Here, we show that the mitochondrial uncoupling agent 2,4-dinitrophenol (DNP) elicits adaptive signaling responses in the cerebral cortex involving activation of Ca(2+) -CREB and autophagy pathways, and inhibition of mTOR and insulin signaling pathways.	2,4-Dinitrophenol	73-76	cAMP responsive element binding protein 1	Mus musculus	170-174
25984632-7	2015	Furthermore, GLP-1 can rapidly stimulate beta-cell CCK production and secretion through direct targeting by the cAMP-modulated transcription factor, cAMP response element binding protein (CREB).	Cyclic AMP	112-116	cAMP responsive element binding protein 1	Mus musculus	149-186
26221964-5	2015	Through mRNA sequencing and NanoString nCounter analysis, we demonstrate that one year of CR feeding suppresses age-dependent signatures of 882 genes functionally associated with synaptic transmission-related pathways, including calcium signaling, long-term potentiation (LTP), and Creb signaling in wild-type mice.	Chromium	90-92	cAMP responsive element binding protein 1	Mus musculus	282-286
25994957-9	2015	Chromatin immunoprecipitation assays revealed that ANG II treatment increased CREB binding to the endogenous PRR promoter in both cultured neurons and hypothalamic tissues of DOCA-salt hypertensive mice.	Desoxycorticosterone Acetate	175-179	cAMP responsive element binding protein 1	Mus musculus	78-82
25994957-9	2015	Chromatin immunoprecipitation assays revealed that ANG II treatment increased CREB binding to the endogenous PRR promoter in both cultured neurons and hypothalamic tissues of DOCA-salt hypertensive mice.	Salts	180-184	cAMP responsive element binding protein 1	Mus musculus	78-82
25994957-11	2015	Collectively, these findings indicate that ANG II acts via AT1R to upregulate PRR expression both in cultured cells and in DOCA-salt hypertensive mice by increasing CREB binding to the PRR promoter.	Salts	128-132	cAMP responsive element binding protein 1	Mus musculus	165-169
26161529-5	2015	In the present study, animals exposed to the chronic unpredictable stress (CUS), a rodent model of depression, exhibited elevated corticosterone, depressive-like behavior, memory deficits, accompanied with decreased cAMP-PKA-CREB and cAMP-ERK1/2-CREB signaling and neuroplasticity.	Cyclic AMP	216-220	cAMP responsive element binding protein 1	Mus musculus	225-229
26036429-0	2015	Decrease of phosphorylated proto-oncogene CREB at Ser 133 site inhibits growth and metastatic activity of renal cell cancer.	Serine	50-53	cAMP responsive element binding protein 1	Mus musculus	42-46
26036429-2	2015	The authors" previous reports showed that blocking the CREB binding site at Ser 133 inhibited the expression of target genes, which related to the progression of some tumors.	Serine	76-79	cAMP responsive element binding protein 1	Mus musculus	55-59
25936754-4	2015	Using the trinitrobenzene sulfonic acid-induced mouse models of intestinal inflammation, we observed decreased SGLT1 expression in the inflamed intestine was positively correlated with the mucosal level of epidermal growth factor (EGF) and activated CREB.	Trinitrobenzenesulfonic Acid	10-39	cAMP responsive element binding protein 1	Mus musculus	250-254
25984632-7	2015	Furthermore, GLP-1 can rapidly stimulate beta-cell CCK production and secretion through direct targeting by the cAMP-modulated transcription factor, cAMP response element binding protein (CREB).	Cyclic AMP	112-116	cAMP responsive element binding protein 1	Mus musculus	188-192
26044058-1	2015	The cyclic adenosine monophosphate response element binding protein (CREB) is a phosphorylation-dependent transcription factor that plays important roles in memory consolidation and several neuropsychological disorders.	Cyclic AMP	4-34	cAMP responsive element binding protein 1	Mus musculus	69-73
26122524-9	2015	Expression levels of mature brain-derived neurotrophic factor (BDNF) and phosphorylated cAMP response element binding protein (CREB) were significantly enhanced by treatment with either PMC-12 or NAC.	pmc-12	186-192	cAMP responsive element binding protein 1	Mus musculus	88-125
26122524-9	2015	Expression levels of mature brain-derived neurotrophic factor (BDNF) and phosphorylated cAMP response element binding protein (CREB) were significantly enhanced by treatment with either PMC-12 or NAC.	pmc-12	186-192	cAMP responsive element binding protein 1	Mus musculus	127-131
26122524-9	2015	Expression levels of mature brain-derived neurotrophic factor (BDNF) and phosphorylated cAMP response element binding protein (CREB) were significantly enhanced by treatment with either PMC-12 or NAC.	Acetylcysteine	196-199	cAMP responsive element binding protein 1	Mus musculus	88-125
26122524-9	2015	Expression levels of mature brain-derived neurotrophic factor (BDNF) and phosphorylated cAMP response element binding protein (CREB) were significantly enhanced by treatment with either PMC-12 or NAC.	Acetylcysteine	196-199	cAMP responsive element binding protein 1	Mus musculus	127-131
25662274-0	2015	Stimulation of StAR expression by cAMP is controlled by inhibition of highly inducible SIK1 via CRTC2, a co-activator of CREB.	Cyclic AMP	34-38	cAMP responsive element binding protein 1	Mus musculus	121-125
26044058-4	2015	Using this technique, we demonstrated the correlation between the change in CREB phosphorylation at a particular region in the brain and behavioral consequences induced by the administration of reserpine, a psychotropic agent.	Reserpine	194-203	cAMP responsive element binding protein 1	Mus musculus	76-80
26031354-4	2015	Here we show that PGE2 enhances Th17 cell differentiation via the activation of the CREB co-activator CRTC2.	Dinoprostone	18-22	cAMP responsive element binding protein 1	Mus musculus	84-88
26038839-5	2015	8-Br-cADPR, an antagonistic cADPR analog, completely blocked glucagon-induced Ca(2+) increases and phosphorylation of cAMP response element-binding protein (CREB).	8-br-	0-5	cAMP responsive element binding protein 1	Mus musculus	118-155
26038839-5	2015	8-Br-cADPR, an antagonistic cADPR analog, completely blocked glucagon-induced Ca(2+) increases and phosphorylation of cAMP response element-binding protein (CREB).	8-br-	0-5	cAMP responsive element binding protein 1	Mus musculus	157-161
26038839-5	2015	8-Br-cADPR, an antagonistic cADPR analog, completely blocked glucagon-induced Ca(2+) increases and phosphorylation of cAMP response element-binding protein (CREB).	Glucagon	61-69	cAMP responsive element binding protein 1	Mus musculus	118-155
26038839-5	2015	8-Br-cADPR, an antagonistic cADPR analog, completely blocked glucagon-induced Ca(2+) increases and phosphorylation of cAMP response element-binding protein (CREB).	Glucagon	61-69	cAMP responsive element binding protein 1	Mus musculus	157-161
26033681-7	2015	We found parecoxib was able to activate CREB, and subsequently maintained the expression of Bcl-2, which is an important mitochondria-associated protein.	parecoxib	9-18	cAMP responsive element binding protein 1	Mus musculus	40-44
26021821-11	2015	Glucagon induced CREB and NOS-3 phosphorylation and increased PGE2 levels in the lung tissue without altering COX-1 expression.	Glucagon	0-8	cAMP responsive element binding protein 1	Mus musculus	17-21
25870201-2	2015	We determined that the AGM is enriched for expression of targets of protein kinase A (PKA)-cAMP response element-binding protein (CREB), a pathway activated by fluid shear stress.	Cyclic AMP	91-95	cAMP responsive element binding protein 1	Mus musculus	130-134
26055129-7	2015	We also demonstrated that kinsenoside increased the phosphorylation of peroxisome proliferator-activated receptor alpha (PPARalpha) and CRE-binding protein (CREB), and the protein levels of silent information regulator T1 (SIRT1), peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1alpha) and carnitine palmitoyltransferase I (CPT1) through an AMPK-dependent mechanism.	3-glucopyranosyloxybutanolide	26-37	cAMP responsive element binding protein 1	Mus musculus	136-155
26055129-7	2015	We also demonstrated that kinsenoside increased the phosphorylation of peroxisome proliferator-activated receptor alpha (PPARalpha) and CRE-binding protein (CREB), and the protein levels of silent information regulator T1 (SIRT1), peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1alpha) and carnitine palmitoyltransferase I (CPT1) through an AMPK-dependent mechanism.	3-glucopyranosyloxybutanolide	26-37	cAMP responsive element binding protein 1	Mus musculus	157-161
26055129-10	2015	In addition, AMPK-phosphorylation-mediated CREB activation caused kinsenoside-mediated PGC-1alpha upregulation.	3-glucopyranosyloxybutanolide	66-77	cAMP responsive element binding protein 1	Mus musculus	43-47
25562427-4	2015	It also induced phosphorylation of CREB (cAMP response element binding protein), but this effect appeared to be mediated indirectly by extracellular signal-regulated kinase (ERK) rather than directly by PKA, given that it was attenuated by the ERK signaling inhibitor U0126.	U 0126	268-273	cAMP responsive element binding protein 1	Mus musculus	35-39
25843525-9	2015	significantly increased the phosphorylation of the cortical and hippocampal PKA/cAMP response element-binding protein (CREB), and was reversed by the co-administration of SCH23390.	Cyclic AMP	80-84	cAMP responsive element binding protein 1	Mus musculus	119-123
25843525-9	2015	significantly increased the phosphorylation of the cortical and hippocampal PKA/cAMP response element-binding protein (CREB), and was reversed by the co-administration of SCH23390.	SCH 23390	171-179	cAMP responsive element binding protein 1	Mus musculus	119-123
25899065-6	2015	CREB phosphorylation, which is implicated in the molecular mechanisms of antidepressant treatment, was abolished in histamine-deficient mice treated with citalopram.	Histamine	116-125	cAMP responsive element binding protein 1	Mus musculus	0-4
25899065-6	2015	CREB phosphorylation, which is implicated in the molecular mechanisms of antidepressant treatment, was abolished in histamine-deficient mice treated with citalopram.	Citalopram	154-164	cAMP responsive element binding protein 1	Mus musculus	0-4
25903150-5	2015	Furthermore, cirsimaritin induced phosphorylation of cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) in a dose-dependent manner after treatment for 15 min.	cirsimaritin	13-25	cAMP responsive element binding protein 1	Mus musculus	125-129
25903150-5	2015	Furthermore, cirsimaritin induced phosphorylation of cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) in a dose-dependent manner after treatment for 15 min.	Cyclic AMP	53-83	cAMP responsive element binding protein 1	Mus musculus	125-129
25903150-5	2015	Furthermore, cirsimaritin induced phosphorylation of cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) in a dose-dependent manner after treatment for 15 min.	Cyclic AMP	85-89	cAMP responsive element binding protein 1	Mus musculus	125-129
25903150-7	2015	These findings indicate that cirsimaritin stimulates melanogenesis in B16F10 cells by activation of CREB as well as upregulation of MITF and tyrosinase expression, which was activated by cAMP signaling.	cirsimaritin	29-41	cAMP responsive element binding protein 1	Mus musculus	100-104
25850013-3	2015	We also revealed through a Western blotting analysis that edaravone (4) induced the phosphorylation of cAMP response element-binding (CREB), a transcription factor that regulates BDNF gene expression; and (5) induced the phosphorylation of extracellular signal-regulated kinases 1/2, an upstream signal factor of CREB.	Edaravone	58-67	cAMP responsive element binding protein 1	Mus musculus	103-132
25850013-3	2015	We also revealed through a Western blotting analysis that edaravone (4) induced the phosphorylation of cAMP response element-binding (CREB), a transcription factor that regulates BDNF gene expression; and (5) induced the phosphorylation of extracellular signal-regulated kinases 1/2, an upstream signal factor of CREB.	Edaravone	58-67	cAMP responsive element binding protein 1	Mus musculus	134-138
25850013-3	2015	We also revealed through a Western blotting analysis that edaravone (4) induced the phosphorylation of cAMP response element-binding (CREB), a transcription factor that regulates BDNF gene expression; and (5) induced the phosphorylation of extracellular signal-regulated kinases 1/2, an upstream signal factor of CREB.	Edaravone	58-67	cAMP responsive element binding protein 1	Mus musculus	313-317
25786521-0	2015	Cadmium up-regulates transcription of the steroidogenic acute regulatory protein (StAR) gene through phosphorylated CREB rather than SF-1 in K28 cells.	Cadmium	0-7	cAMP responsive element binding protein 1	Mus musculus	116-120
25786521-5	2015	Cadmium treatment caused an increase in CREB phosphorylation but did not alter the CREB protein level in the nucleus.	Cadmium	0-7	cAMP responsive element binding protein 1	Mus musculus	40-44
25786521-6	2015	EMSA studies revealed that cadmium-induced phosphorylated CREB formed specific complexes with the proximal region of the StAR gene promoter.	Cadmium	27-34	cAMP responsive element binding protein 1	Mus musculus	58-62
25786521-7	2015	Furthermore, co-transfection with a CREB expression plasmid significantly increased cadmium-induced StAR promoter activity.	Cadmium	84-91	cAMP responsive element binding protein 1	Mus musculus	36-40
25927059-2	2015	The present study investigated the radioprotective effect of rolipram, a specific phosphodiesterase type-IV inhibitor known to increase the expression and phosphorylation of the cyclic adenosine monophosphate response element-binding protein (CREB), a key factor for spermatogenesis, with the testicular system against pelvic irradiation.	Rolipram	61-69	cAMP responsive element binding protein 1	Mus musculus	243-247
25927059-9	2015	These findings suggest that activation of CREB signaling by rolipram treatment ameliorates the detrimental effects of acute irradiation on testicular dysfunction and the related male reproductive functions in mice.	Rolipram	60-68	cAMP responsive element binding protein 1	Mus musculus	42-46
25889478-8	2015	Phosphorylation of CREB in the spinal cord after the intraplantar formalin injection was decreased in BLT1 knockout mice.	Formaldehyde	66-74	cAMP responsive element binding protein 1	Mus musculus	19-23
25889478-9	2015	In addition, mice pretreated with a BLT1 antagonist showed reduced nociception and attenuated CREB phosphorylation in the spinal cord after the formalin injection.	Formaldehyde	144-152	cAMP responsive element binding protein 1	Mus musculus	94-98
25730876-4	2015	Ethanol exposure blocked the recruitment of CREB and its coactivator CRTC2 to gluconeogenic promoters by up-regulating ATF3, a transcriptional repressor that also binds to cAMP-responsive elements and thereby down-regulates gluconeogenic genes.	Ethanol	0-7	cAMP responsive element binding protein 1	Mus musculus	44-48
25730876-4	2015	Ethanol exposure blocked the recruitment of CREB and its coactivator CRTC2 to gluconeogenic promoters by up-regulating ATF3, a transcriptional repressor that also binds to cAMP-responsive elements and thereby down-regulates gluconeogenic genes.	Cyclic AMP	172-176	cAMP responsive element binding protein 1	Mus musculus	44-48
25940704-6	2015	Genistein treatments, knockdown of EMP2 gene and double knockdown of CREB1 and EMP2 genes significantly inhibited tumor growth and notably downregulated CREB1 and EMP2 protein levels in the mice xenograft models.	Genistein	0-9	cAMP responsive element binding protein 1	Mus musculus	153-158
25940704-7	2015	Therefore, genistein induced CREB1 transcription, translation and upregulated pCREB1(S133) protein level.	Genistein	11-20	cAMP responsive element binding protein 1	Mus musculus	29-34
25786521-9	2015	Taken together, these results suggest that cadmium up-regulates StAR gene expression through phosphorylated CREB rather than through SF-1 in mouse testicular Leydig cells.	Cadmium	43-50	cAMP responsive element binding protein 1	Mus musculus	108-112
25730876-3	2015	Here we show that acute ethanol exposure also lowers fasting blood glucose concentrations by inhibiting the CREB-mediated activation of the gluconeogenic program in response to glucagon.	Ethanol	24-31	cAMP responsive element binding protein 1	Mus musculus	108-112
25730876-3	2015	Here we show that acute ethanol exposure also lowers fasting blood glucose concentrations by inhibiting the CREB-mediated activation of the gluconeogenic program in response to glucagon.	Glucose	67-74	cAMP responsive element binding protein 1	Mus musculus	108-112
25730876-3	2015	Here we show that acute ethanol exposure also lowers fasting blood glucose concentrations by inhibiting the CREB-mediated activation of the gluconeogenic program in response to glucagon.	Glucagon	177-185	cAMP responsive element binding protein 1	Mus musculus	108-112
25204460-5	2015	Nimodipine-induced TrkB phosphorylation was associated with increased phosphorylation levels of Akt and CREB in the prefrontal cortex and the hippocampus whereas phosphorylation of ERK, mTor and p70S6k remained unaltered.	Nimodipine	0-10	cAMP responsive element binding protein 1	Mus musculus	104-108
25562427-4	2015	It also induced phosphorylation of CREB (cAMP response element binding protein), but this effect appeared to be mediated indirectly by extracellular signal-regulated kinase (ERK) rather than directly by PKA, given that it was attenuated by the ERK signaling inhibitor U0126.	U 0126	268-273	cAMP responsive element binding protein 1	Mus musculus	41-78
25924512-5	2015	Furthermore, the expression of cyclic adenosine monophosphate response element binding protein (CREB) and microphthalmia transcription factor (MITF) was increased by tangeretin in 1 h and 4 h, respectively.	Cyclic AMP	31-61	cAMP responsive element binding protein 1	Mus musculus	96-100
25500291-3	2015	We hypothesized that EPO induces the CREB (cAMP [adenosine 3"5" cyclic monophosphate] response element-binding protein) pathway and neurotrophin production in the murine spinal cord, attenuating functional and cellular injury.	Cyclic AMP	43-47	cAMP responsive element binding protein 1	Mus musculus	37-41
25500291-3	2015	We hypothesized that EPO induces the CREB (cAMP [adenosine 3"5" cyclic monophosphate] response element-binding protein) pathway and neurotrophin production in the murine spinal cord, attenuating functional and cellular injury.	Cyclic AMP	49-84	cAMP responsive element binding protein 1	Mus musculus	37-41
25451297-9	2015	Therefore, the use of LiCl to balance between beta-catenin and CREB effectors could be considered as an efficient remyelinating strategy.	Lithium Chloride	22-26	cAMP responsive element binding protein 1	Mus musculus	63-67
25451297-0	2015	Lithium chloride stimulates PLP and MBP expression in oligodendrocytes via Wnt/beta-catenin and Akt/CREB pathways.	Lithium Chloride	0-16	cAMP responsive element binding protein 1	Mus musculus	100-104
25664930-3	2015	Broader in vitro selectivity profiling shows that PU139 blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB (cAMP response element-binding) protein (CBP) and p300, whereas PU141 is selective toward CBP and p300.	PU139	50-55	cAMP responsive element binding protein 1	Mus musculus	113-117
25503787-1	2015	Since oxidative stress is critically involved in excitotoxic damage, we sought to determine whether the activation of the transcription factors, cAMP-responsive element binding protein (CREB) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2, also known as NFE2L2), by alpha-iso-cubebene is involved in its protective effects against glutamate-induced neuronal cell death.	alpha-iso-cubebene	273-291	cAMP responsive element binding protein 1	Mus musculus	145-184
25503787-1	2015	Since oxidative stress is critically involved in excitotoxic damage, we sought to determine whether the activation of the transcription factors, cAMP-responsive element binding protein (CREB) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2, also known as NFE2L2), by alpha-iso-cubebene is involved in its protective effects against glutamate-induced neuronal cell death.	Glutamic Acid	338-347	cAMP responsive element binding protein 1	Mus musculus	145-184
25503787-9	2015	Furthermore, the knockdown of CREB and Nrf2 by small interfering RNA attenuated the neuroprotective effects of alpha-iso-cubebene.	alpha-iso-cubebene	111-129	cAMP responsive element binding protein 1	Mus musculus	30-34
25503787-10	2015	Taken together, our results indicate that alpha-iso-cubebene protects HT22 cells from glutamate-induced oxidative damage through the activation of Nrf2/HO-1/NQO-1, as well as through the PKA and CREB signaling pathways.	alpha-iso-cubebene	42-60	cAMP responsive element binding protein 1	Mus musculus	195-199
25503787-10	2015	Taken together, our results indicate that alpha-iso-cubebene protects HT22 cells from glutamate-induced oxidative damage through the activation of Nrf2/HO-1/NQO-1, as well as through the PKA and CREB signaling pathways.	Glutamic Acid	86-95	cAMP responsive element binding protein 1	Mus musculus	195-199
26119951-4	2015	Treatment with glutamate alone led to suppressed protein level of mature brain-derived neurotrophic factor (BDNF) and phosphorylated cAMP response element binding protein (CREB); however, pretreatment with either WEPM or anti-oxidant N-acetyl-L-cysteine (NAC) resulted in the significant enhancement of levels of these proteins.	Glutamic Acid	15-24	cAMP responsive element binding protein 1	Mus musculus	133-170
25453775-4	2015	Pre-treatment with H89, a PKA inhibitor, prevented the activation of CREB by ephrinB2-Fc.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	19-22	cAMP responsive element binding protein 1	Mus musculus	69-73
25593297-1	2015	The cAMP response element (CRE)-binding protein, CREB, is a transcription factor whose activity in the brain is critical for long-term memory formation.	Cyclic AMP	4-8	cAMP responsive element binding protein 1	Mus musculus	49-53
26119951-4	2015	Treatment with glutamate alone led to suppressed protein level of mature brain-derived neurotrophic factor (BDNF) and phosphorylated cAMP response element binding protein (CREB); however, pretreatment with either WEPM or anti-oxidant N-acetyl-L-cysteine (NAC) resulted in the significant enhancement of levels of these proteins.	Glutamic Acid	15-24	cAMP responsive element binding protein 1	Mus musculus	172-176
26119951-4	2015	Treatment with glutamate alone led to suppressed protein level of mature brain-derived neurotrophic factor (BDNF) and phosphorylated cAMP response element binding protein (CREB); however, pretreatment with either WEPM or anti-oxidant N-acetyl-L-cysteine (NAC) resulted in the significant enhancement of levels of these proteins.	Acetylcysteine	234-253	cAMP responsive element binding protein 1	Mus musculus	172-176
26119951-4	2015	Treatment with glutamate alone led to suppressed protein level of mature brain-derived neurotrophic factor (BDNF) and phosphorylated cAMP response element binding protein (CREB); however, pretreatment with either WEPM or anti-oxidant N-acetyl-L-cysteine (NAC) resulted in the significant enhancement of levels of these proteins.	Acetylcysteine	255-258	cAMP responsive element binding protein 1	Mus musculus	172-176
26119951-5	2015	In addition, levels of mature BDNF expression and CREB phosphorylation were increased by combined treatment with WEPM, NAC, and intracellular Ca (2+) inhibitor BAPTA compared to other treatment groups.	Acetylcysteine	119-122	cAMP responsive element binding protein 1	Mus musculus	50-54
26119951-5	2015	In addition, levels of mature BDNF expression and CREB phosphorylation were increased by combined treatment with WEPM, NAC, and intracellular Ca (2+) inhibitor BAPTA compared to other treatment groups.	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	160-165	cAMP responsive element binding protein 1	Mus musculus	50-54
26424009-7	2015	Furthermore, osthole treatment upregulated expression of brain-derived neurotrophic factor (BDNF) and enhanced activation of the BDNF receptor tyrosine receptor kinase B (TrkB) following increased phosphorylation of cyclic AMP response element-binding protein (CREB), indicating that osthole improves neurogenesis via stimulating BDNF/TrkB/CREB signaling in APP/PS1 transgenic mice.	osthol	13-20	cAMP responsive element binding protein 1	Mus musculus	216-259
26424009-7	2015	Furthermore, osthole treatment upregulated expression of brain-derived neurotrophic factor (BDNF) and enhanced activation of the BDNF receptor tyrosine receptor kinase B (TrkB) following increased phosphorylation of cyclic AMP response element-binding protein (CREB), indicating that osthole improves neurogenesis via stimulating BDNF/TrkB/CREB signaling in APP/PS1 transgenic mice.	osthol	284-291	cAMP responsive element binding protein 1	Mus musculus	216-259
26424009-7	2015	Furthermore, osthole treatment upregulated expression of brain-derived neurotrophic factor (BDNF) and enhanced activation of the BDNF receptor tyrosine receptor kinase B (TrkB) following increased phosphorylation of cyclic AMP response element-binding protein (CREB), indicating that osthole improves neurogenesis via stimulating BDNF/TrkB/CREB signaling in APP/PS1 transgenic mice.	osthol	13-20	cAMP responsive element binding protein 1	Mus musculus	261-265
26424009-7	2015	Furthermore, osthole treatment upregulated expression of brain-derived neurotrophic factor (BDNF) and enhanced activation of the BDNF receptor tyrosine receptor kinase B (TrkB) following increased phosphorylation of cyclic AMP response element-binding protein (CREB), indicating that osthole improves neurogenesis via stimulating BDNF/TrkB/CREB signaling in APP/PS1 transgenic mice.	osthol	13-20	cAMP responsive element binding protein 1	Mus musculus	340-344
25334089-4	2015	The effects of pinacidil on the activation of phosphoinositide 3-kinase (PI3K), Akt and cyclic adenosine monophosphate-responsive element-binding protein (CREB) were also examined.	Pinacidil	15-24	cAMP responsive element binding protein 1	Mus musculus	155-159
23628005-8	2015	Moreover, BPS can induce cAMP response elements (CRE) binding to the iNOS promoter and phospho- cAMP response element binding protein (CREB) expression in a cyclic AMP-dependent manner.	Cyclic AMP	157-167	cAMP responsive element binding protein 1	Mus musculus	96-133
23628005-8	2015	Moreover, BPS can induce cAMP response elements (CRE) binding to the iNOS promoter and phospho- cAMP response element binding protein (CREB) expression in a cyclic AMP-dependent manner.	Cyclic AMP	157-167	cAMP responsive element binding protein 1	Mus musculus	135-139
23628005-10	2015	In conclusion, we demonstrated that BPS or adv-COX-1/PGIS increases PGI2 levels through iNOS expression and peroxynitrite production, via CREB protein phosphorylation; thereby aggravating DOX-mediated cardiotoxicity.	Prostaglandins I	53-57	cAMP responsive element binding protein 1	Mus musculus	138-142
24732144-0	2015	CREB/TRH pathway in the central nervous system regulates energy expenditure in response to deprivation of an essential amino acid.	Amino Acids, Essential	109-129	cAMP responsive element binding protein 1	Mus musculus	0-4
24732144-21	2015	Lastly, TRH expression was regulated by CREB, which was phosphorylated by ERK1/2 and dephosphorylated by PPP1R3C-containing protein Ser/Thr phosphatase type 1 (PP1) under leucine deprivation in vitro.	Leucine	171-178	cAMP responsive element binding protein 1	Mus musculus	40-44
26115221-2	2015	Phosphorylation of the transcription factor cAMP-responsive element binding protein (CREB) significantly increased in cells treated with high glucose (HG) compared to cell grown in normal glucose (NG).	Glucose	142-149	cAMP responsive element binding protein 1	Mus musculus	44-83
26115221-2	2015	Phosphorylation of the transcription factor cAMP-responsive element binding protein (CREB) significantly increased in cells treated with high glucose (HG) compared to cell grown in normal glucose (NG).	Glucose	142-149	cAMP responsive element binding protein 1	Mus musculus	85-89
26115221-2	2015	Phosphorylation of the transcription factor cAMP-responsive element binding protein (CREB) significantly increased in cells treated with high glucose (HG) compared to cell grown in normal glucose (NG).	Glucose	188-195	cAMP responsive element binding protein 1	Mus musculus	44-83
26115221-2	2015	Phosphorylation of the transcription factor cAMP-responsive element binding protein (CREB) significantly increased in cells treated with high glucose (HG) compared to cell grown in normal glucose (NG).	Glucose	188-195	cAMP responsive element binding protein 1	Mus musculus	85-89
26115221-3	2015	Cells pretreated with rapamycin before exposure to HG showed significant decrease phosphorylation of CREB, increase in AMPK activity and decrease protein/mRNA and promoter activity of fibronectin.	Sirolimus	22-31	cAMP responsive element binding protein 1	Mus musculus	101-105
26115221-7	2015	Furthermore, db/db mice treated with rapamycin showed significant increase in AMPK activity, decrease in expression of p-CREB and protein/mRNA of fibronectin.	Sirolimus	37-46	cAMP responsive element binding protein 1	Mus musculus	121-125
26202357-7	2015	RESULTS: THC administration 2h prior to the induction of hepatic I/R was associated with significant attenuated elevations of: serum liver transaminases ALT and AST, the hepatic oxidative stress (activation of the intracellular signaling CREB pathway), the acute proinflammatory response (TNF-alpha, IL-1alpha, IL-10 and c-FOS hepatic mRNA levels, and ERK signaling pathway activation).	Dronabinol	9-12	cAMP responsive element binding protein 1	Mus musculus	238-242
26202357-7	2015	RESULTS: THC administration 2h prior to the induction of hepatic I/R was associated with significant attenuated elevations of: serum liver transaminases ALT and AST, the hepatic oxidative stress (activation of the intracellular signaling CREB pathway), the acute proinflammatory response (TNF-alpha, IL-1alpha, IL-10 and c-FOS hepatic mRNA levels, and ERK signaling pathway activation).	Deuterium	28-30	cAMP responsive element binding protein 1	Mus musculus	238-242
25680961-5	2015	Attenuated cAMP-PKA signaling can lead to a reduced activity of the transcription factor cAMP response element binding protein (CREB) and ultimately affect the expression of genes and proteins involved in neuronal plasticity and memory formation.	Cyclic AMP	11-15	cAMP responsive element binding protein 1	Mus musculus	89-126
25680961-5	2015	Attenuated cAMP-PKA signaling can lead to a reduced activity of the transcription factor cAMP response element binding protein (CREB) and ultimately affect the expression of genes and proteins involved in neuronal plasticity and memory formation.	Cyclic AMP	11-15	cAMP responsive element binding protein 1	Mus musculus	128-132
25334089-7	2015	Pinacidil inhibited antimycin A-induced inactivation of PI3K and Akt as well as phosphorylation of CREB and TrxR.	Pinacidil	0-9	cAMP responsive element binding protein 1	Mus musculus	99-103
25334089-7	2015	Pinacidil inhibited antimycin A-induced inactivation of PI3K and Akt as well as phosphorylation of CREB and TrxR.	Antimycin A	20-31	cAMP responsive element binding protein 1	Mus musculus	99-103
25334089-9	2015	In conclusion, these results suggested that pinacidil may rescue osteoblastic cells from antimycin A-induced cellular damage, potentially via antioxidant activity and restoration of mitochondrial function, which are mediated in part by the PI3K/Akt/CREB signaling pathway.	Pinacidil	44-53	cAMP responsive element binding protein 1	Mus musculus	249-253
25334089-9	2015	In conclusion, these results suggested that pinacidil may rescue osteoblastic cells from antimycin A-induced cellular damage, potentially via antioxidant activity and restoration of mitochondrial function, which are mediated in part by the PI3K/Akt/CREB signaling pathway.	Antimycin A	89-100	cAMP responsive element binding protein 1	Mus musculus	249-253
25301235-7	2014	In addition, we confirmed that the expression of both cAMP responsive element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in the hippocampus of Abeta(1-42)-injected mice were markedly upregulated by the treatment of BPB-316.	bpb	240-243	cAMP responsive element binding protein 1	Mus musculus	54-93
25451330-7	2015	NPY showed suppression in a receptor-dependent manner, inhibition of endogenous cAMP production and cAMP-PKA-dependent pathways p38 MAPK and CREB phosphorylation were involved in the downstream mechanisms.	Cyclic AMP	100-104	cAMP responsive element binding protein 1	Mus musculus	141-145
25677772-5	2015	We have shown that nociceptin, known as a neuropeptide, is upregulated by FSH signaling through cAMP/PKA/CREB pathway in Sertoli cells of postnatal murine testes.	Cyclic AMP	96-100	cAMP responsive element binding protein 1	Mus musculus	105-109
23507145-4	2014	Here, we showed the elimination of reactive oxygen species (ROS) by antioxidants probucol or superoxide dismutase (SOD)/catalase blocks Abeta-mediated inactivation of protein kinase A (PKA)/cAMP regulatory-element-binding (CREB) signal transduction pathway and loss of synapse, suggesting the detrimental effects of oxidative stress on neuronal PKA/CREB activity.	Reactive Oxygen Species	35-58	cAMP responsive element binding protein 1	Mus musculus	223-227
23507145-4	2014	Here, we showed the elimination of reactive oxygen species (ROS) by antioxidants probucol or superoxide dismutase (SOD)/catalase blocks Abeta-mediated inactivation of protein kinase A (PKA)/cAMP regulatory-element-binding (CREB) signal transduction pathway and loss of synapse, suggesting the detrimental effects of oxidative stress on neuronal PKA/CREB activity.	Reactive Oxygen Species	35-58	cAMP responsive element binding protein 1	Mus musculus	349-353
23507145-4	2014	Here, we showed the elimination of reactive oxygen species (ROS) by antioxidants probucol or superoxide dismutase (SOD)/catalase blocks Abeta-mediated inactivation of protein kinase A (PKA)/cAMP regulatory-element-binding (CREB) signal transduction pathway and loss of synapse, suggesting the detrimental effects of oxidative stress on neuronal PKA/CREB activity.	Reactive Oxygen Species	60-63	cAMP responsive element binding protein 1	Mus musculus	223-227
23507145-4	2014	Here, we showed the elimination of reactive oxygen species (ROS) by antioxidants probucol or superoxide dismutase (SOD)/catalase blocks Abeta-mediated inactivation of protein kinase A (PKA)/cAMP regulatory-element-binding (CREB) signal transduction pathway and loss of synapse, suggesting the detrimental effects of oxidative stress on neuronal PKA/CREB activity.	Reactive Oxygen Species	60-63	cAMP responsive element binding protein 1	Mus musculus	349-353
23507145-4	2014	Here, we showed the elimination of reactive oxygen species (ROS) by antioxidants probucol or superoxide dismutase (SOD)/catalase blocks Abeta-mediated inactivation of protein kinase A (PKA)/cAMP regulatory-element-binding (CREB) signal transduction pathway and loss of synapse, suggesting the detrimental effects of oxidative stress on neuronal PKA/CREB activity.	Probucol	81-89	cAMP responsive element binding protein 1	Mus musculus	223-227
23507145-4	2014	Here, we showed the elimination of reactive oxygen species (ROS) by antioxidants probucol or superoxide dismutase (SOD)/catalase blocks Abeta-mediated inactivation of protein kinase A (PKA)/cAMP regulatory-element-binding (CREB) signal transduction pathway and loss of synapse, suggesting the detrimental effects of oxidative stress on neuronal PKA/CREB activity.	Probucol	81-89	cAMP responsive element binding protein 1	Mus musculus	349-353
23507145-4	2014	Here, we showed the elimination of reactive oxygen species (ROS) by antioxidants probucol or superoxide dismutase (SOD)/catalase blocks Abeta-mediated inactivation of protein kinase A (PKA)/cAMP regulatory-element-binding (CREB) signal transduction pathway and loss of synapse, suggesting the detrimental effects of oxidative stress on neuronal PKA/CREB activity.	Cyclic AMP	190-194	cAMP responsive element binding protein 1	Mus musculus	223-227
23507145-4	2014	Here, we showed the elimination of reactive oxygen species (ROS) by antioxidants probucol or superoxide dismutase (SOD)/catalase blocks Abeta-mediated inactivation of protein kinase A (PKA)/cAMP regulatory-element-binding (CREB) signal transduction pathway and loss of synapse, suggesting the detrimental effects of oxidative stress on neuronal PKA/CREB activity.	Cyclic AMP	190-194	cAMP responsive element binding protein 1	Mus musculus	349-353
25416030-9	2014	Furthermore, we found that sildenafil induced phosphorylated cAMP response element binding protein (CREB) and reduced CREB-binding protein 1 (CBP1) recruitment to Smad transcriptional complexes.	Sildenafil Citrate	27-37	cAMP responsive element binding protein 1	Mus musculus	61-98
25416030-9	2014	Furthermore, we found that sildenafil induced phosphorylated cAMP response element binding protein (CREB) and reduced CREB-binding protein 1 (CBP1) recruitment to Smad transcriptional complexes.	Sildenafil Citrate	27-37	cAMP responsive element binding protein 1	Mus musculus	100-104
25759053-9	2015	In cultured cells, nobiletin reversed the Abeta-induced inhibition of glutamate-induced increases in cAMP response element binding protein (CREB) phosphorylation and modulated gen expression of thioredoxin-interacting protein and NMDA resceptor subunits.	nobiletin	19-28	cAMP responsive element binding protein 1	Mus musculus	101-138
25759053-9	2015	In cultured cells, nobiletin reversed the Abeta-induced inhibition of glutamate-induced increases in cAMP response element binding protein (CREB) phosphorylation and modulated gen expression of thioredoxin-interacting protein and NMDA resceptor subunits.	nobiletin	19-28	cAMP responsive element binding protein 1	Mus musculus	140-144
25759053-9	2015	In cultured cells, nobiletin reversed the Abeta-induced inhibition of glutamate-induced increases in cAMP response element binding protein (CREB) phosphorylation and modulated gen expression of thioredoxin-interacting protein and NMDA resceptor subunits.	UNII-042A8N37WH	42-47	cAMP responsive element binding protein 1	Mus musculus	101-138
25759053-9	2015	In cultured cells, nobiletin reversed the Abeta-induced inhibition of glutamate-induced increases in cAMP response element binding protein (CREB) phosphorylation and modulated gen expression of thioredoxin-interacting protein and NMDA resceptor subunits.	UNII-042A8N37WH	42-47	cAMP responsive element binding protein 1	Mus musculus	140-144
25759053-9	2015	In cultured cells, nobiletin reversed the Abeta-induced inhibition of glutamate-induced increases in cAMP response element binding protein (CREB) phosphorylation and modulated gen expression of thioredoxin-interacting protein and NMDA resceptor subunits.	Glutamic Acid	70-79	cAMP responsive element binding protein 1	Mus musculus	101-138
25759053-9	2015	In cultured cells, nobiletin reversed the Abeta-induced inhibition of glutamate-induced increases in cAMP response element binding protein (CREB) phosphorylation and modulated gen expression of thioredoxin-interacting protein and NMDA resceptor subunits.	Glutamic Acid	70-79	cAMP responsive element binding protein 1	Mus musculus	140-144
25664020-0	2014	The cyclic AMP response element-binding protein antisense oligonucleotide induced anti-nociception and decreased the expression of KIF17 in spinal cord after peripheral nerve injury in mice.	Oligonucleotides	58-73	cAMP responsive element binding protein 1	Mus musculus	4-47
25664020-4	2014	This study is to investigate the role and mechanism of CREB antisense oligonucleotide (ODN) in neuropathic pain induced by chronic constriction injury (CCI) in mice.	Oligonucleotides	70-85	cAMP responsive element binding protein 1	Mus musculus	55-59
25664020-4	2014	This study is to investigate the role and mechanism of CREB antisense oligonucleotide (ODN) in neuropathic pain induced by chronic constriction injury (CCI) in mice.	odn	87-90	cAMP responsive element binding protein 1	Mus musculus	55-59
25664020-5	2014	RESULTS: CCI surgery decreased thresholds of mechanical allodynia and thermal hyperalgesia whereas CREB antisense oligonucleotide ODN significantly attenuated these pain behaviors (P &lt; 0.05).	Oligonucleotides	114-129	cAMP responsive element binding protein 1	Mus musculus	99-103
25664020-6	2014	CCI significantly induced the protein expression of phosphorylated CREB (pCREB) and KIF17, but not KIF5B, in the spinal cord of CCI mice (P &lt; 0.05).	CCI	0-3	cAMP responsive element binding protein 1	Mus musculus	67-71
25664020-9	2014	CONCLUSIONS: CREB antisense oligonucleotide ODN may reduce neuropathic pain through targeting CREB and decreasing the expression of pCREB and KIF17.	Oligonucleotides	28-43	cAMP responsive element binding protein 1	Mus musculus	13-17
25664020-9	2014	CONCLUSIONS: CREB antisense oligonucleotide ODN may reduce neuropathic pain through targeting CREB and decreasing the expression of pCREB and KIF17.	Oligonucleotides	28-43	cAMP responsive element binding protein 1	Mus musculus	94-98
25301235-7	2014	In addition, we confirmed that the expression of both cAMP responsive element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in the hippocampus of Abeta(1-42)-injected mice were markedly upregulated by the treatment of BPB-316.	bpb	240-243	cAMP responsive element binding protein 1	Mus musculus	95-99
25685661-6	2015	Piperine also decreased the phosphorylation of CREB, which is up-regulated by eugenol.	piperine	0-8	cAMP responsive element binding protein 1	Mus musculus	47-51
25685661-6	2015	Piperine also decreased the phosphorylation of CREB, which is up-regulated by eugenol.	Eugenol	78-85	cAMP responsive element binding protein 1	Mus musculus	47-51
25505876-1	2014	The cyclic AMP (cAMP)-response element binding protein (CREB) is an activity-dependent transcription factor playing a role in synaptic plasticity, learning and memory, and emotional behavior.	Cyclic AMP	4-14	cAMP responsive element binding protein 1	Mus musculus	56-60
25685661-7	2015	These results suggest that piperine inhibits the eugenol-induced signal transduction pathway through modulation of cAMP and calcium levels and phosphorylation of CREB in non-chemosensory cells.	piperine	27-35	cAMP responsive element binding protein 1	Mus musculus	162-166
25505876-1	2014	The cyclic AMP (cAMP)-response element binding protein (CREB) is an activity-dependent transcription factor playing a role in synaptic plasticity, learning and memory, and emotional behavior.	Cyclic AMP	16-20	cAMP responsive element binding protein 1	Mus musculus	56-60
25685661-7	2015	These results suggest that piperine inhibits the eugenol-induced signal transduction pathway through modulation of cAMP and calcium levels and phosphorylation of CREB in non-chemosensory cells.	Eugenol	49-56	cAMP responsive element binding protein 1	Mus musculus	162-166
25415296-11	2014	Moreover, 7,8-DHF increased brain-derived neurotrophic factor levels and promoted cAMP response element-binding protein (CREB) activation.	6,7-dihydroxyflavone	10-17	cAMP responsive element binding protein 1	Mus musculus	82-119
25415296-11	2014	Moreover, 7,8-DHF increased brain-derived neurotrophic factor levels and promoted cAMP response element-binding protein (CREB) activation.	6,7-dihydroxyflavone	10-17	cAMP responsive element binding protein 1	Mus musculus	121-125
25415296-15	2014	Our study demonstrates that activation of TrkB signaling by 7,8-DHF protects against TBI via the PI3K/Akt but not Erk pathway, and this protective effect may be amplified via the PI3K/Akt-CREB cascades.	6,7-dihydroxyflavone	60-67	cAMP responsive element binding protein 1	Mus musculus	188-192
25573318-4	2014	And the heat and mechanical hyperalgesia responses were used to examine the affect of ERK5 in CCI-induced neuropathic pain and the expression of p-CREB (cAMP response-element binding protein) in spinal cord.	Cyclic AMP	153-157	cAMP responsive element binding protein 1	Mus musculus	147-151
25128602-7	2014	Our study suggested that a chronic increase of NMDARs activation by NR2B overexpression in the forebrain may enhance the protein serine/threonine phosphorylation levels of MAPK/ERK-CREB and thereby regulated their signaling pathway.	Serine	129-135	cAMP responsive element binding protein 1	Mus musculus	181-185
25573318-6	2014	Compared with saline group, mechanical and thermal hyperalgesia significantly decreased and the expression of p-CREB protein decreased at spinal cord in oligonucleotide group.	Sodium Chloride	14-20	cAMP responsive element binding protein 1	Mus musculus	112-116
25573318-6	2014	Compared with saline group, mechanical and thermal hyperalgesia significantly decreased and the expression of p-CREB protein decreased at spinal cord in oligonucleotide group.	Oligonucleotides	153-168	cAMP responsive element binding protein 1	Mus musculus	112-116
24898145-1	2014	Cyclic AMP promotes chronic expression of target genes mainly by protein kinase A-dependent activation of CREB transcription factor machineries in the metabolic tissues.	Cyclic AMP	0-10	cAMP responsive element binding protein 1	Mus musculus	106-110
25049196-9	2014	GE administration also resulted in phosphorylation of extracellular-signal-regulated kinase (ERK) and cyclic AMP response element-binding protein (CREB), as revealed by Western blotting analysis.	Cyclic AMP	102-112	cAMP responsive element binding protein 1	Mus musculus	147-151
24906890-8	2014	Thus, our results indicate that mitochondrial H2O2 is a key culprit of age-associated cognitive impairment, and that a reduction of mitochondrial H2O2 could improve cognition by maintaining mitochondrial health and enhancing CREB signaling.	Hydrogen Peroxide	146-150	cAMP responsive element binding protein 1	Mus musculus	225-229
25609594-5	2014	We also found that ethanol inhibits cyclic adenosine monophosphate response element-binding protein (CREB) phosphorylation and activity-regulated cytoskeleton-associated protein (Arc) expression in neonatal and adult mice.	Ethanol	19-26	cAMP responsive element binding protein 1	Mus musculus	101-105
25609594-6	2014	The blockade or genetic deletion of CB1Rs prior to ethanol treatment at P7 rescued CREB phosphorylation and Arc expression.	Ethanol	51-58	cAMP responsive element binding protein 1	Mus musculus	83-87
25319707-6	2014	Ablating or silencing neurons overexpressing CREB (but not a similar number of random LA neurons) before testing disrupted the expression of a previously acquired cocaine memory, suggesting that neurons overexpressing CREB become a critical hub in what is likely a larger cocaine memory engram.	Cocaine	163-170	cAMP responsive element binding protein 1	Mus musculus	45-49
25319707-6	2014	Ablating or silencing neurons overexpressing CREB (but not a similar number of random LA neurons) before testing disrupted the expression of a previously acquired cocaine memory, suggesting that neurons overexpressing CREB become a critical hub in what is likely a larger cocaine memory engram.	Cocaine	163-170	cAMP responsive element binding protein 1	Mus musculus	218-222
25319707-6	2014	Ablating or silencing neurons overexpressing CREB (but not a similar number of random LA neurons) before testing disrupted the expression of a previously acquired cocaine memory, suggesting that neurons overexpressing CREB become a critical hub in what is likely a larger cocaine memory engram.	Cocaine	272-279	cAMP responsive element binding protein 1	Mus musculus	45-49
25319707-6	2014	Ablating or silencing neurons overexpressing CREB (but not a similar number of random LA neurons) before testing disrupted the expression of a previously acquired cocaine memory, suggesting that neurons overexpressing CREB become a critical hub in what is likely a larger cocaine memory engram.	Cocaine	272-279	cAMP responsive element binding protein 1	Mus musculus	218-222
25111229-11	2014	In vitro studies showed that asbestos-induced inflammasome/inflammation activation in mesothelial cells was CREB dependent, further supporting the role of CREB in inflammation-induced MM pathogenesis.	Asbestos	29-37	cAMP responsive element binding protein 1	Mus musculus	108-112
25111229-11	2014	In vitro studies showed that asbestos-induced inflammasome/inflammation activation in mesothelial cells was CREB dependent, further supporting the role of CREB in inflammation-induced MM pathogenesis.	Asbestos	29-37	cAMP responsive element binding protein 1	Mus musculus	155-159
25051446-13	2014	Chronic nicotine treatment enhanced PI-3-kinase activities and increased Akt and glycogen synthase kinase (GSK)-3beta phosphorylation in an nAChR-dependent manner coupled with decreased cAMP response element-binding protein (CREB) phosphorylation.	Nicotine	8-16	cAMP responsive element binding protein 1	Mus musculus	186-223
25051446-13	2014	Chronic nicotine treatment enhanced PI-3-kinase activities and increased Akt and glycogen synthase kinase (GSK)-3beta phosphorylation in an nAChR-dependent manner coupled with decreased cAMP response element-binding protein (CREB) phosphorylation.	Nicotine	8-16	cAMP responsive element binding protein 1	Mus musculus	225-229
25195769-8	2014	Attenuated photic phase shifts in buspirone-treated hamsters were accompanied by decreased phosphorylation of ERK and CREB.	Buspirone	34-43	cAMP responsive element binding protein 1	Mus musculus	118-122
25063812-9	2014	Furthermore, treatment with forskolin, an adenylyl cyclase agonist, rescued phospho-Creb in PCs and reversed the impairment in PF-PC LTD in Lgr4(-/-) cerebellar slices, indicating that Lgr4 is an upstream regulator of Creb signaling, which is underlying PF-PC LTD.	Colforsin	28-37	cAMP responsive element binding protein 1	Mus musculus	84-88
25129807-6	2014	To understand the underlying mechanism, we assessed changes in phosphorylated CREB at Ser(133) (pCREB) immunoreactivity in the dBNST and central nucleus of the amygdala (CeA).	Serine	86-89	cAMP responsive element binding protein 1	Mus musculus	78-82
25063812-9	2014	Furthermore, treatment with forskolin, an adenylyl cyclase agonist, rescued phospho-Creb in PCs and reversed the impairment in PF-PC LTD in Lgr4(-/-) cerebellar slices, indicating that Lgr4 is an upstream regulator of Creb signaling, which is underlying PF-PC LTD.	Colforsin	28-37	cAMP responsive element binding protein 1	Mus musculus	218-222
24994661-8	2014	Mechanistic investigations showed that kaempferol suppresses RSK2 and MSK1 kinase activities to attenuate SUV-induced phosphorylation of cAMP-responsive element binding protein (CREB) and histone H3 in mouse skin cells.	kaempferol	39-49	cAMP responsive element binding protein 1	Mus musculus	137-176
24952295-12	2014	Our findings suggests a neuroprotective potential of ABT-239 and its combinations with SVP and TDZD-8 against KA-induced neurotoxicity, possibly mediated through in part each by modulating Akt/GSK3beta and CREB pathways.	benzonitrile, 4-(2-(2-((2r)-2-methyl-1-pyrrolidinyl)ethyl)-5-benzofuranyl)-	53-60	cAMP responsive element binding protein 1	Mus musculus	206-210
24952295-12	2014	Our findings suggests a neuroprotective potential of ABT-239 and its combinations with SVP and TDZD-8 against KA-induced neurotoxicity, possibly mediated through in part each by modulating Akt/GSK3beta and CREB pathways.	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione	95-101	cAMP responsive element binding protein 1	Mus musculus	206-210
24994661-8	2014	Mechanistic investigations showed that kaempferol suppresses RSK2 and MSK1 kinase activities to attenuate SUV-induced phosphorylation of cAMP-responsive element binding protein (CREB) and histone H3 in mouse skin cells.	kaempferol	39-49	cAMP responsive element binding protein 1	Mus musculus	178-182
24994661-10	2014	Further analysis showed that skin from the kaempferol-treated group exhibited a substantial reduction in SUV-induced phosphorylation of CREB, c-Fos, and histone H3.	kaempferol	43-53	cAMP responsive element binding protein 1	Mus musculus	136-140
24722246-5	2014	IP deletion depressed cAMP-dependent CREB phosphorylation and elevated AKT phosphorylation by suppressing PI3K-gamma/PKC-zeta-mediated TRB3 expression, which subsequently downregulated the gluconeogenic genes for glucose-6-phosphatase (G6Pase) and phosphoenol pyruvate carboxykinase 1 in hepatocytes.	Cyclic AMP	22-26	cAMP responsive element binding protein 1	Mus musculus	37-41
25066354-0	2014	Extremely low frequency electromagnetic field exposure causes cognitive impairment associated with alteration of the glutamate level, MAPK pathway activation and decreased CREB phosphorylation in mice hippocampus: reversal by procyanidins extracted from the lotus seedpod.	Proanthocyanidins	226-238	cAMP responsive element binding protein 1	Mus musculus	172-176
24937021-0	2014	Benzyl butyl phthalate exposure impairs learning and memory and attenuates neurotransmission and CREB phosphorylation in mice.	butylbenzyl phthalate	0-22	cAMP responsive element binding protein 1	Mus musculus	97-101
24937021-7	2014	The modified levels of 5-HT in the hippocampus and the decreased levels of CREB phosphorylation after BBP exposure suggested a potential mechanism underlying BBP toxicity.	butylbenzyl phthalate	102-105	cAMP responsive element binding protein 1	Mus musculus	75-79
24937021-7	2014	The modified levels of 5-HT in the hippocampus and the decreased levels of CREB phosphorylation after BBP exposure suggested a potential mechanism underlying BBP toxicity.	butylbenzyl phthalate	158-161	cAMP responsive element binding protein 1	Mus musculus	75-79
24937021-8	2014	We hypothesize that BBP exposure causes a decrease in the number of neurotransmitters, which in turn down regulates the levels of CREB phosphorylation by the cAMP/protein kinase A (PKA)-mediated signaling.	butylbenzyl phthalate	20-23	cAMP responsive element binding protein 1	Mus musculus	130-134
25066354-9	2014	Thus, the results from the present study suggest that p-ERK1/2, p-JNK1/2, [Ca(2+)]i and p-CREB expression normalized, possibly via a NMDA receptor-channel through the changes of GABA, glutamate and NR2B, which might be responsible for the neuroprotective or memory enhancing effects of LSPCs.	gamma-Aminobutyric Acid	178-182	cAMP responsive element binding protein 1	Mus musculus	90-94
25066354-9	2014	Thus, the results from the present study suggest that p-ERK1/2, p-JNK1/2, [Ca(2+)]i and p-CREB expression normalized, possibly via a NMDA receptor-channel through the changes of GABA, glutamate and NR2B, which might be responsible for the neuroprotective or memory enhancing effects of LSPCs.	Glutamic Acid	184-193	cAMP responsive element binding protein 1	Mus musculus	90-94
24792671-0	2014	Inhibition of receptor activator of nuclear factor-kappaB ligand- or lipopolysaccharide-induced osteoclast formation by conophylline through downregulation of CREB.	conophylline	120-132	cAMP responsive element binding protein 1	Mus musculus	159-163
24705918-1	2014	Inhibition of phosphodiesterase-4 or 5 (PDE4 or PDE5) increases cyclic adenosine monophosphate (cAMP)- or cyclic guanosine monophosphate (cGMP), respectively, which activates cAMP response element-binding protein (CREB)/brain-derived neurotrophic factor (BDNF)/neuropeptide VGF (non-acryonimic) signaling and produces antidepressant-like effects on behavior.	Cyclic GMP	106-136	cAMP responsive element binding protein 1	Mus musculus	175-212
25079084-0	2014	BDNF-ERK-CREB signalling mediates the role of miR-132 in the regulation of the effects of oleanolic acid in male mice.	Oleanolic Acid	90-104	cAMP responsive element binding protein 1	Mus musculus	9-13
25079084-5	2014	Furthermore, we found that oleanolic acid led to the BDNF-related phosphorylation and activation of extracellular signal-regulated kinases (ERK) and cyclic adenosine monophosphate response element binding protein (CREB), which was associated with the upregulation of miR-132 and hippocampal neuronal proliferation.	Oleanolic Acid	27-41	cAMP responsive element binding protein 1	Mus musculus	214-218
25079084-9	2014	CONCLUSION: Our results show that oleanolic acid induces the upregulation of miR-132, which serves as an important regulator of neurotrophic actions, mainly through the activation of the hippocampal BDNF-ERK-CREB signalling pathways.	Oleanolic Acid	34-48	cAMP responsive element binding protein 1	Mus musculus	208-212
24705918-1	2014	Inhibition of phosphodiesterase-4 or 5 (PDE4 or PDE5) increases cyclic adenosine monophosphate (cAMP)- or cyclic guanosine monophosphate (cGMP), respectively, which activates cAMP response element-binding protein (CREB)/brain-derived neurotrophic factor (BDNF)/neuropeptide VGF (non-acryonimic) signaling and produces antidepressant-like effects on behavior.	Cyclic AMP	64-94	cAMP responsive element binding protein 1	Mus musculus	175-212
24705918-1	2014	Inhibition of phosphodiesterase-4 or 5 (PDE4 or PDE5) increases cyclic adenosine monophosphate (cAMP)- or cyclic guanosine monophosphate (cGMP), respectively, which activates cAMP response element-binding protein (CREB)/brain-derived neurotrophic factor (BDNF)/neuropeptide VGF (non-acryonimic) signaling and produces antidepressant-like effects on behavior.	Cyclic GMP	106-136	cAMP responsive element binding protein 1	Mus musculus	214-218
24705918-1	2014	Inhibition of phosphodiesterase-4 or 5 (PDE4 or PDE5) increases cyclic adenosine monophosphate (cAMP)- or cyclic guanosine monophosphate (cGMP), respectively, which activates cAMP response element-binding protein (CREB)/brain-derived neurotrophic factor (BDNF)/neuropeptide VGF (non-acryonimic) signaling and produces antidepressant-like effects on behavior.	Cyclic AMP	64-94	cAMP responsive element binding protein 1	Mus musculus	214-218
24705918-1	2014	Inhibition of phosphodiesterase-4 or 5 (PDE4 or PDE5) increases cyclic adenosine monophosphate (cAMP)- or cyclic guanosine monophosphate (cGMP), respectively, which activates cAMP response element-binding protein (CREB)/brain-derived neurotrophic factor (BDNF)/neuropeptide VGF (non-acryonimic) signaling and produces antidepressant-like effects on behavior.	Cyclic AMP	96-100	cAMP responsive element binding protein 1	Mus musculus	175-212
24705918-8	2014	The results suggest that inhibition of PDE4 by etazolate or PDE5 by sildenafil produced antidepressant-like effects in CUMS-treated animals via cAMP or cGMP signaling, which shares the common downstream signal pathway of CREB/BDNF/VGF.	Etazolate	47-56	cAMP responsive element binding protein 1	Mus musculus	221-225
24705918-1	2014	Inhibition of phosphodiesterase-4 or 5 (PDE4 or PDE5) increases cyclic adenosine monophosphate (cAMP)- or cyclic guanosine monophosphate (cGMP), respectively, which activates cAMP response element-binding protein (CREB)/brain-derived neurotrophic factor (BDNF)/neuropeptide VGF (non-acryonimic) signaling and produces antidepressant-like effects on behavior.	Cyclic AMP	96-100	cAMP responsive element binding protein 1	Mus musculus	214-218
24705918-8	2014	The results suggest that inhibition of PDE4 by etazolate or PDE5 by sildenafil produced antidepressant-like effects in CUMS-treated animals via cAMP or cGMP signaling, which shares the common downstream signal pathway of CREB/BDNF/VGF.	Sildenafil Citrate	68-78	cAMP responsive element binding protein 1	Mus musculus	221-225
24705918-8	2014	The results suggest that inhibition of PDE4 by etazolate or PDE5 by sildenafil produced antidepressant-like effects in CUMS-treated animals via cAMP or cGMP signaling, which shares the common downstream signal pathway of CREB/BDNF/VGF.	cums	119-123	cAMP responsive element binding protein 1	Mus musculus	221-225
24705918-8	2014	The results suggest that inhibition of PDE4 by etazolate or PDE5 by sildenafil produced antidepressant-like effects in CUMS-treated animals via cAMP or cGMP signaling, which shares the common downstream signal pathway of CREB/BDNF/VGF.	Cyclic AMP	144-148	cAMP responsive element binding protein 1	Mus musculus	221-225
24705918-8	2014	The results suggest that inhibition of PDE4 by etazolate or PDE5 by sildenafil produced antidepressant-like effects in CUMS-treated animals via cAMP or cGMP signaling, which shares the common downstream signal pathway of CREB/BDNF/VGF.	Cyclic GMP	152-156	cAMP responsive element binding protein 1	Mus musculus	221-225
25298661-7	2014	In addition, phosphorylation of PKA and CREB by alpha-MSH stimulation was efficiently blocked by MA128 pretreatment.	ma128	97-102	cAMP responsive element binding protein 1	Mus musculus	40-44
25379405-1	2014	OBJECTIVE: Glucagon-like peptide-1 (GLP-1) plays a major role in pancreatic beta-cell function and survival by increasing cytoplasmic cAMP levels, which are thought to affect transcription through activation of the basic leucine zipper (bZIP) transcription factor CREB.	Cyclic AMP	134-138	cAMP responsive element binding protein 1	Mus musculus	264-268
25379405-4	2014	RESULTS: By ablating CREB acutely in mature beta-cells in tamoxifen-treated Creb (loxP/loxP);Pdx1-CreERT2 mice, we show that CREB has little impact on beta-cell turnover, in contrast to what had been postulated previously.	Tamoxifen	58-67	cAMP responsive element binding protein 1	Mus musculus	21-25
25379405-4	2014	RESULTS: By ablating CREB acutely in mature beta-cells in tamoxifen-treated Creb (loxP/loxP);Pdx1-CreERT2 mice, we show that CREB has little impact on beta-cell turnover, in contrast to what had been postulated previously.	Tamoxifen	58-67	cAMP responsive element binding protein 1	Mus musculus	76-80
25379405-4	2014	RESULTS: By ablating CREB acutely in mature beta-cells in tamoxifen-treated Creb (loxP/loxP);Pdx1-CreERT2 mice, we show that CREB has little impact on beta-cell turnover, in contrast to what had been postulated previously.	Tamoxifen	58-67	cAMP responsive element binding protein 1	Mus musculus	125-129
25379405-5	2014	Rather, CREB is required for GLP-1 to elicit its full effects on stimulating glucose-induced insulin secretion and protection from cytokine-induced apoptosis.	Glucose	77-84	cAMP responsive element binding protein 1	Mus musculus	8-12
24903074-0	2014	miR-27 inhibits adipocyte differentiation via suppressing CREB expression.	mir-27	0-6	cAMP responsive element binding protein 1	Mus musculus	58-62
25047355-6	2014	Increased neuronal activity results in the calcium-mediated activation of CaM kinase IV, phosphorylation of CREB, increased expression of antiapoptotic and neurotrophic molecules and reduced apoptosis of cortical neurons following injury.	Calcium	43-50	cAMP responsive element binding protein 1	Mus musculus	108-112
24682499-10	2014	Further, repeated treatment with lobeline or 3-(pyridine-3-yl)-cytisine decreased immobility time in the FST and reduced withdrawal-induced increased BDNF and p-CREB expression in the hippocampus.	Lobeline	33-41	cAMP responsive element binding protein 1	Mus musculus	161-165
24682499-10	2014	Further, repeated treatment with lobeline or 3-(pyridine-3-yl)-cytisine decreased immobility time in the FST and reduced withdrawal-induced increased BDNF and p-CREB expression in the hippocampus.	3-(pyridine-3-yl)-cytisine	45-71	cAMP responsive element binding protein 1	Mus musculus	161-165
24550142-5	2014	Significantly, the activation of GPR40 provoked the phosphorylation of the cAMP response element-binding protein, CREB.	Cyclic AMP	75-79	cAMP responsive element binding protein 1	Mus musculus	114-118
24306628-0	2014	G protein-coupled estrogen receptor-protein kinase A-ERK-CREB signaling pathway is involved in the regulation of mouse gubernaculum testis cells by diethylstilbestrol.	Diethylstilbestrol	148-166	cAMP responsive element binding protein 1	Mus musculus	57-61
24306628-7	2014	In addition, we found that DES induced the activation of CREB downstream of PKA, Src, and ERK1/2 in these cells.	Diethylstilbestrol	27-30	cAMP responsive element binding protein 1	Mus musculus	57-61
24648181-8	2014	URB597 impaired CaMKIV and CREB phosphorylation in WT but not in KO mice.	cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester	0-6	cAMP responsive element binding protein 1	Mus musculus	27-31
24648181-10	2014	Our results indicate that pharmacologically elevated AEA impair LTP, learning and memory and inhibit CaMKIV and CREB phosphorylation, via the activation of CB1Rs.	anandamide	53-56	cAMP responsive element binding protein 1	Mus musculus	112-116
24306628-8	2014	These data suggest that the effects of DES on mouse gubernaculum testis cells are mediated at least partially by GPER-protein kinase A-ERK-CREB signaling pathway.	Diethylstilbestrol	39-42	cAMP responsive element binding protein 1	Mus musculus	139-143
24464529-5	2014	After behavioral assessment, brains of the mice were analyzed immunohistochemically to quantify the phosphorylation of cAMP-responsive element binding protein (CREB), a downstream component of the cAMP pathway.	Cyclic AMP	119-123	cAMP responsive element binding protein 1	Mus musculus	160-164
24464529-10	2014	Cilostazol also significantly increased the number of phosphorylated-CREB-positive cells in hippocampal dentate gyrus.	Cilostazol	0-10	cAMP responsive element binding protein 1	Mus musculus	69-73
24124769-4	2014	Furthermore, ubiquinol-10 may activate Sirt1 and PGC-1alpha by increasing cyclic adenosine monophosphate (cAMP) levels that, in turn, activate cAMP response element-binding protein (CREB) and AMP-activated protein kinase (AMPK).	ubiquinol-10	13-25	cAMP responsive element binding protein 1	Mus musculus	143-180
24124769-4	2014	Furthermore, ubiquinol-10 may activate Sirt1 and PGC-1alpha by increasing cyclic adenosine monophosphate (cAMP) levels that, in turn, activate cAMP response element-binding protein (CREB) and AMP-activated protein kinase (AMPK).	ubiquinol-10	13-25	cAMP responsive element binding protein 1	Mus musculus	182-186
24966820-0	2014	CREB activity in dopamine D1 receptor expressing neurons regulates cocaine-induced behavioral effects.	Cocaine	67-74	cAMP responsive element binding protein 1	Mus musculus	0-4
24966820-2	2014	To test the cell-specificity of this hypothesis we examined the effects of a dominant-negative CREB protein variant expressed in dopamine receptor D1 (D1R) neurons on cocaine-induced behaviors.	Cocaine	167-174	cAMP responsive element binding protein 1	Mus musculus	95-99
24657159-7	2014	Excessive intake of D-galactose not only impaired memory, which was indicated by passive avoidance, Y-maze, and Morris water-maze tasks, but also reduced the expression of brain-derived neurotrophic factor (BDNF) and hippocampal doublecortin (DCX) and the activation of cAMP response element-binding protein (CREB).	Galactose	20-31	cAMP responsive element binding protein 1	Mus musculus	270-307
24657159-7	2014	Excessive intake of D-galactose not only impaired memory, which was indicated by passive avoidance, Y-maze, and Morris water-maze tasks, but also reduced the expression of brain-derived neurotrophic factor (BDNF) and hippocampal doublecortin (DCX) and the activation of cAMP response element-binding protein (CREB).	Galactose	20-31	cAMP responsive element binding protein 1	Mus musculus	309-313
24124769-4	2014	Furthermore, ubiquinol-10 may activate Sirt1 and PGC-1alpha by increasing cyclic adenosine monophosphate (cAMP) levels that, in turn, activate cAMP response element-binding protein (CREB) and AMP-activated protein kinase (AMPK).	Cyclic AMP	74-104	cAMP responsive element binding protein 1	Mus musculus	143-180
24124769-4	2014	Furthermore, ubiquinol-10 may activate Sirt1 and PGC-1alpha by increasing cyclic adenosine monophosphate (cAMP) levels that, in turn, activate cAMP response element-binding protein (CREB) and AMP-activated protein kinase (AMPK).	Cyclic AMP	74-104	cAMP responsive element binding protein 1	Mus musculus	182-186
24124769-4	2014	Furthermore, ubiquinol-10 may activate Sirt1 and PGC-1alpha by increasing cyclic adenosine monophosphate (cAMP) levels that, in turn, activate cAMP response element-binding protein (CREB) and AMP-activated protein kinase (AMPK).	Cyclic AMP	106-110	cAMP responsive element binding protein 1	Mus musculus	143-180
24124769-4	2014	Furthermore, ubiquinol-10 may activate Sirt1 and PGC-1alpha by increasing cyclic adenosine monophosphate (cAMP) levels that, in turn, activate cAMP response element-binding protein (CREB) and AMP-activated protein kinase (AMPK).	Cyclic AMP	106-110	cAMP responsive element binding protein 1	Mus musculus	182-186
24632067-3	2014	Betulinic acid significantly attenuated 3-isobutyl-1-methylxanthine (IBMX)-induced melanin production by inhibiting tyrosinase, tyrosinase related protein (TRP)-1, and TRP-2 expression through the modulation of their corresponding transcription factors, microphthalamia associated transcription factor (MITF) and cAMP response element binding protein (CREB), in B16F10 cells.	betulinic acid	0-14	cAMP responsive element binding protein 1	Mus musculus	313-350
24632067-3	2014	Betulinic acid significantly attenuated 3-isobutyl-1-methylxanthine (IBMX)-induced melanin production by inhibiting tyrosinase, tyrosinase related protein (TRP)-1, and TRP-2 expression through the modulation of their corresponding transcription factors, microphthalamia associated transcription factor (MITF) and cAMP response element binding protein (CREB), in B16F10 cells.	1-Methyl-3-isobutylxanthine	40-67	cAMP responsive element binding protein 1	Mus musculus	352-356
24531539-9	2014	E6 cells also responded differentially from E8 neurons regarding cyclic AMP-responsive element-binding protein (CREB) activation in the retina in vivo.	Cyclic AMP	65-75	cAMP responsive element binding protein 1	Mus musculus	112-116
24595858-2	2014	The cAMP responsive transcription factor cAMP responsive element binding protein (CREB), thought to be a key activator of the hepatic gluconeogenic gene regulation programme, has been suggested as a therapeutic target to reduce glucose output by the liver.	Cyclic AMP	4-8	cAMP responsive element binding protein 1	Mus musculus	41-80
24595858-2	2014	The cAMP responsive transcription factor cAMP responsive element binding protein (CREB), thought to be a key activator of the hepatic gluconeogenic gene regulation programme, has been suggested as a therapeutic target to reduce glucose output by the liver.	Cyclic AMP	4-8	cAMP responsive element binding protein 1	Mus musculus	82-86
24595858-2	2014	The cAMP responsive transcription factor cAMP responsive element binding protein (CREB), thought to be a key activator of the hepatic gluconeogenic gene regulation programme, has been suggested as a therapeutic target to reduce glucose output by the liver.	Glucose	228-235	cAMP responsive element binding protein 1	Mus musculus	41-80
24595858-2	2014	The cAMP responsive transcription factor cAMP responsive element binding protein (CREB), thought to be a key activator of the hepatic gluconeogenic gene regulation programme, has been suggested as a therapeutic target to reduce glucose output by the liver.	Glucose	228-235	cAMP responsive element binding protein 1	Mus musculus	82-86
24632067-3	2014	Betulinic acid significantly attenuated 3-isobutyl-1-methylxanthine (IBMX)-induced melanin production by inhibiting tyrosinase, tyrosinase related protein (TRP)-1, and TRP-2 expression through the modulation of their corresponding transcription factors, microphthalamia associated transcription factor (MITF) and cAMP response element binding protein (CREB), in B16F10 cells.	1-Methyl-3-isobutylxanthine	69-73	cAMP responsive element binding protein 1	Mus musculus	313-350
24632067-3	2014	Betulinic acid significantly attenuated 3-isobutyl-1-methylxanthine (IBMX)-induced melanin production by inhibiting tyrosinase, tyrosinase related protein (TRP)-1, and TRP-2 expression through the modulation of their corresponding transcription factors, microphthalamia associated transcription factor (MITF) and cAMP response element binding protein (CREB), in B16F10 cells.	betulinic acid	0-14	cAMP responsive element binding protein 1	Mus musculus	352-356
24632067-3	2014	Betulinic acid significantly attenuated 3-isobutyl-1-methylxanthine (IBMX)-induced melanin production by inhibiting tyrosinase, tyrosinase related protein (TRP)-1, and TRP-2 expression through the modulation of their corresponding transcription factors, microphthalamia associated transcription factor (MITF) and cAMP response element binding protein (CREB), in B16F10 cells.	1-Methyl-3-isobutylxanthine	69-73	cAMP responsive element binding protein 1	Mus musculus	352-356
24632067-6	2014	As a result, betulinic acid inhibited melanin production by tyrosinase, TRP-1, and TRP-2 inhibition through the regulation of CREB and MITF, which was accompanied with MEK/ERK and PI3K/Akt inactivation in IBMX-stimulated B16F10 cells.	betulinic acid	13-27	cAMP responsive element binding protein 1	Mus musculus	126-130
24632067-6	2014	As a result, betulinic acid inhibited melanin production by tyrosinase, TRP-1, and TRP-2 inhibition through the regulation of CREB and MITF, which was accompanied with MEK/ERK and PI3K/Akt inactivation in IBMX-stimulated B16F10 cells.	Melanins	38-45	cAMP responsive element binding protein 1	Mus musculus	126-130
24632067-3	2014	Betulinic acid significantly attenuated 3-isobutyl-1-methylxanthine (IBMX)-induced melanin production by inhibiting tyrosinase, tyrosinase related protein (TRP)-1, and TRP-2 expression through the modulation of their corresponding transcription factors, microphthalamia associated transcription factor (MITF) and cAMP response element binding protein (CREB), in B16F10 cells.	1-Methyl-3-isobutylxanthine	40-67	cAMP responsive element binding protein 1	Mus musculus	313-350
24712702-0	2014	Effects of curcumin (Curcuma longa) on learning and spatial memory as well as cell proliferation and neuroblast differentiation in adult and aged mice by upregulating brain-derived neurotrophic factor and CREB signaling.	Curcumin	11-19	cAMP responsive element binding protein 1	Mus musculus	205-209
24550127-3	2014	Therefore, we analyzed initially in mouse hippocampus the daytime-dependent dynamics of parameters, known to be important for proper memory formation, like phosphorylation of the "memory molecule" cyclic adenosine monophosphate (cAMP) responsive element binding protein (CREB) and chromatin remodeling.	Cyclic AMP	197-227	cAMP responsive element binding protein 1	Mus musculus	271-275
24550127-3	2014	Therefore, we analyzed initially in mouse hippocampus the daytime-dependent dynamics of parameters, known to be important for proper memory formation, like phosphorylation of the "memory molecule" cyclic adenosine monophosphate (cAMP) responsive element binding protein (CREB) and chromatin remodeling.	Cyclic AMP	229-233	cAMP responsive element binding protein 1	Mus musculus	271-275
24356899-6	2014	Moreover, after EGCG treatment, TrkA signaling was activated by increasing the phosphorylation of TrkA following the increased phosphorylation of c-Raf, ERK1/2, and cAMP response element-binding protein (CREB), simultaneously the p75NTR signaling was significantly inhibited by decreasing the p75ICD expression, JNK2 phosphorylation, and cleaved-caspase 3 expression, so that the Abeta deposits and neuronal apoptosis in the hippocampus were inhibited.	epigallocatechin gallate	16-20	cAMP responsive element binding protein 1	Mus musculus	165-202
24356899-6	2014	Moreover, after EGCG treatment, TrkA signaling was activated by increasing the phosphorylation of TrkA following the increased phosphorylation of c-Raf, ERK1/2, and cAMP response element-binding protein (CREB), simultaneously the p75NTR signaling was significantly inhibited by decreasing the p75ICD expression, JNK2 phosphorylation, and cleaved-caspase 3 expression, so that the Abeta deposits and neuronal apoptosis in the hippocampus were inhibited.	epigallocatechin gallate	16-20	cAMP responsive element binding protein 1	Mus musculus	204-208
24855942-3	2014	Loss of TRPV1 inactivates a calcium-signaling cascade that ends in the nuclear exclusion of the CREB-regulated transcriptional coactivator CRTC1 within pain sensory neurons originating from the spinal cord.	Calcium	28-35	cAMP responsive element binding protein 1	Mus musculus	96-100
24606396-6	2014	Treatment with 5-HT significantly enhanced the ATRA-induced expression of nestin, a specific marker for NPC, and phosphorylation of cAMP response element-binding protein (CREB).	Tretinoin	47-51	cAMP responsive element binding protein 1	Mus musculus	132-169
24674967-3	2014	Here, we show that beta-agonists or catecholamines released during intense exercise induce Creb-mediated transcriptional programs through activation of its obligate coactivators Crtc2 and Crtc3.	Catecholamines	36-50	cAMP responsive element binding protein 1	Mus musculus	91-95
24556046-8	2014	Only Ass1 expression is induced by cAMP through PKA/p-Creb signaling pathway.	Cyclic AMP	35-39	cAMP responsive element binding protein 1	Mus musculus	54-58
24606396-6	2014	Treatment with 5-HT significantly enhanced the ATRA-induced expression of nestin, a specific marker for NPC, and phosphorylation of cAMP response element-binding protein (CREB).	Tretinoin	47-51	cAMP responsive element binding protein 1	Mus musculus	171-175
24606396-8	2014	These findings suggest that stimulation of 5-HT4 receptors may enhance ATRA-induced neural differentiation of mouse iPS cells through activation of PKA and CREB.	Tretinoin	71-75	cAMP responsive element binding protein 1	Mus musculus	156-160
24482397-9	2014	Bifenthrin-modified SCO rapidly enhanced the phosphorylation of cAMP response element-binding protein (CREB).	bifenthrin	0-10	cAMP responsive element binding protein 1	Mus musculus	64-101
24790206-6	2014	Using Designer Receptors Exclusively Activated by Designer Drugs (DREADD) technology, we showed that selectively increasing cAMP levels in VTA dopamine neurons increased phosphorylation of TH at Ser40 and CREB at Ser133 and reversed behavioral deficits induced by Cdk5 deletion.	Cyclic AMP	124-128	cAMP responsive element binding protein 1	Mus musculus	205-209
24790206-6	2014	Using Designer Receptors Exclusively Activated by Designer Drugs (DREADD) technology, we showed that selectively increasing cAMP levels in VTA dopamine neurons increased phosphorylation of TH at Ser40 and CREB at Ser133 and reversed behavioral deficits induced by Cdk5 deletion.	Dopamine	143-151	cAMP responsive element binding protein 1	Mus musculus	205-209
24678753-6	2014	Further, the phosphorylated CREB protein level of SAMP8 was markedly up-regulated by SP feeding.	sp	85-87	cAMP responsive element binding protein 1	Mus musculus	28-32
24695708-7	2014	The RIalphaB-expressing mice also exhibit decreased locomotor activity and decreased dopamine-regulated CREB phosphorylation and c-fos gene expression in the striatum.	Dopamine	85-93	cAMP responsive element binding protein 1	Mus musculus	104-108
24552231-6	2014	In addition, actein increased the phosphorylation of CREB (cAMP-response element-binding protein) inhibited by antimycin A and decreased the production of TNF-alpha induced by antimycin A.	Antimycin A	111-122	cAMP responsive element binding protein 1	Mus musculus	53-57
24552231-6	2014	In addition, actein increased the phosphorylation of CREB (cAMP-response element-binding protein) inhibited by antimycin A and decreased the production of TNF-alpha induced by antimycin A.	Antimycin A	111-122	cAMP responsive element binding protein 1	Mus musculus	59-96
24552231-6	2014	In addition, actein increased the phosphorylation of CREB (cAMP-response element-binding protein) inhibited by antimycin A and decreased the production of TNF-alpha induced by antimycin A.	Antimycin A	176-187	cAMP responsive element binding protein 1	Mus musculus	53-57
24552231-6	2014	In addition, actein increased the phosphorylation of CREB (cAMP-response element-binding protein) inhibited by antimycin A and decreased the production of TNF-alpha induced by antimycin A.	Antimycin A	176-187	cAMP responsive element binding protein 1	Mus musculus	59-96
24482397-9	2014	Bifenthrin-modified SCO rapidly enhanced the phosphorylation of cAMP response element-binding protein (CREB).	bifenthrin	0-10	cAMP responsive element binding protein 1	Mus musculus	103-107
24482397-11	2014	Bifenthrin-stimulated neurite outgrowth and CREB phosphorylation were dependent on mGluR5 activity since MPEP normalized both responses.	bifenthrin	0-10	cAMP responsive element binding protein 1	Mus musculus	44-48
24452697-8	2014	RESULTS: MPH + FLX, or cocaine exposure in juvenile mice increased mRNA expression of ERK2 and its downstream targets (CREB, cFos, and Zif268), and increased protein phosphorylation of ERK2 and CREB 2 months after drug exposure.	Fluoxetine	15-18	cAMP responsive element binding protein 1	Mus musculus	119-123
24333148-6	2014	Activation of the GPR39-Zn(2+)-sensing receptor (GPR39) triggers diverse neuronal pathways leading to a cAMP-responsive element binding the protein (CREB) expression, which then induces synthesis of the brain-derived neurotrophic factor and, in turn, activation of the Tropomyosin receptor kinase B (TrkB) receptor.	Cyclic AMP	104-108	cAMP responsive element binding protein 1	Mus musculus	149-153
24269543-8	2014	In DHC, the levels of VGLUT2, p-ERK1/2 and CREB expressions were reduced during the stress-induced reinstatement, which could be reversed by OT and further abolished by Ato.	dhc	3-6	cAMP responsive element binding protein 1	Mus musculus	43-47
24269543-8	2014	In DHC, the levels of VGLUT2, p-ERK1/2 and CREB expressions were reduced during the stress-induced reinstatement, which could be reversed by OT and further abolished by Ato.	Oxytocin	141-143	cAMP responsive element binding protein 1	Mus musculus	43-47
24269543-8	2014	In DHC, the levels of VGLUT2, p-ERK1/2 and CREB expressions were reduced during the stress-induced reinstatement, which could be reversed by OT and further abolished by Ato.	atosiban	169-172	cAMP responsive element binding protein 1	Mus musculus	43-47
24450802-8	2014	In addition, soyasaponins preserved brain-derived neurotrophic factor (BNDF) expression (F = 33.69, P &lt; 0.05) and cAMP response element-binding (CREB) protein phosphorylation (F = 91.62, P &lt; 0.05) in the hippocampus of scopolamine-treated mice.	soyasaponins	13-25	cAMP responsive element binding protein 1	Mus musculus	117-146
24495472-9	2014	Further analysis was performed in CFA-induced mice exploring various molecular and signaling pathways such as NF-kappaB, AP-1, and ERK-CREB involved in the persistent pain sensations.	3-chloro-4-fluoroaniline	34-37	cAMP responsive element binding protein 1	Mus musculus	135-139
24495472-12	2014	Further analysis was performed in CFA-induced mice exploring various molecular and signaling pathways such as NF-kappaB, AP-1 and ERK-CREB involved in the persistent of pain sensations.	3-chloro-4-fluoroaniline	34-37	cAMP responsive element binding protein 1	Mus musculus	134-138
24603712-8	2014	Using the IL-6 promoter as a model, we demonstrated that TNF-alpha/isoproterenol cotreatment provoked phosphorylation of histone H3 at serine 10, concomitant with enhanced promoter accessibility and recruitment of the NF-kappaB p65 subunit, cAMP-response element-binding protein (CREB), CREB-binding protein (CBP) and RNA polymerase II.	Isoproterenol	67-80	cAMP responsive element binding protein 1	Mus musculus	241-278
24603712-8	2014	Using the IL-6 promoter as a model, we demonstrated that TNF-alpha/isoproterenol cotreatment provoked phosphorylation of histone H3 at serine 10, concomitant with enhanced promoter accessibility and recruitment of the NF-kappaB p65 subunit, cAMP-response element-binding protein (CREB), CREB-binding protein (CBP) and RNA polymerase II.	Isoproterenol	67-80	cAMP responsive element binding protein 1	Mus musculus	280-284
24378735-3	2014	Dibutyryl cAMP activated PKA and enhanced the phosphorylation of cAMP response element (CRE)-binding protein (CREB).	Cyclic AMP	10-14	cAMP responsive element binding protein 1	Mus musculus	110-114
24378735-3	2014	Dibutyryl cAMP activated PKA and enhanced the phosphorylation of cAMP response element (CRE)-binding protein (CREB).	Cyclic AMP	65-69	cAMP responsive element binding protein 1	Mus musculus	110-114
24378735-6	2014	Furthermore, okadaic acid, a protein phosphatase (PP) 1/2A inhibitor, suppressed the progression of adipogenesis by preventing PP1/2A-mediated suppression of CREB-dependent COX-2 expression, thus resulting in increased production of anti-adipogenic PGE2 and PGF2alpha.	Okadaic Acid	13-25	cAMP responsive element binding protein 1	Mus musculus	158-162
24378735-6	2014	Furthermore, okadaic acid, a protein phosphatase (PP) 1/2A inhibitor, suppressed the progression of adipogenesis by preventing PP1/2A-mediated suppression of CREB-dependent COX-2 expression, thus resulting in increased production of anti-adipogenic PGE2 and PGF2alpha.	Dinoprostone	249-253	cAMP responsive element binding protein 1	Mus musculus	158-162
24378735-6	2014	Furthermore, okadaic acid, a protein phosphatase (PP) 1/2A inhibitor, suppressed the progression of adipogenesis by preventing PP1/2A-mediated suppression of CREB-dependent COX-2 expression, thus resulting in increased production of anti-adipogenic PGE2 and PGF2alpha.	Dinoprost	258-267	cAMP responsive element binding protein 1	Mus musculus	158-162
24378735-7	2014	These results indicate that CREB-dependent expression of COX-2 for the production of anti-adipogenic PGs is critical for the regulation of the early phase of adipogenesis.	Phosphatidylglycerols	101-104	cAMP responsive element binding protein 1	Mus musculus	28-32
24450802-8	2014	In addition, soyasaponins preserved brain-derived neurotrophic factor (BNDF) expression (F = 33.69, P &lt; 0.05) and cAMP response element-binding (CREB) protein phosphorylation (F = 91.62, P &lt; 0.05) in the hippocampus of scopolamine-treated mice.	soyasaponins	13-25	cAMP responsive element binding protein 1	Mus musculus	148-152
24450802-10	2014	On the basis of these findings, we suggest that soybean, particularly soyasaponins, may protect memory impairment by increasing BDNF expression and CREB phosphorylation.	soyasaponins	70-82	cAMP responsive element binding protein 1	Mus musculus	148-152
24634580-3	2014	Moreover, the effects of stress and agomelatine on brain-derived neurotrophic factor (BDNF) and cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) messenger ribonucleic acid (mRNA) levels in the hippocampus was also determined using quantitative real-time polymerase chain reaction (RT-PCR).	Cyclic AMP	96-126	cAMP responsive element binding protein 1	Mus musculus	168-172
24364879-7	2014	Further study demonstrated that the NRG-1beta-induced phosphorylation of CREB was required for cardiomyogenesis of mESCs.	1,2-Di(anthracen-9-yl)ethyne	40-45	cAMP responsive element binding protein 1	Mus musculus	73-77
24634580-3	2014	Moreover, the effects of stress and agomelatine on brain-derived neurotrophic factor (BDNF) and cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) messenger ribonucleic acid (mRNA) levels in the hippocampus was also determined using quantitative real-time polymerase chain reaction (RT-PCR).	Cyclic AMP	128-132	cAMP responsive element binding protein 1	Mus musculus	168-172
24634580-9	2014	Quantitative RT-PCR revealed that CREB and BDNF gene expression levels were downregulated in UCMS-exposed mice, and these alterations were reversed by chronic agomelatine or melatonin treatment.	Melatonin	174-183	cAMP responsive element binding protein 1	Mus musculus	34-38
24634580-9	2014	Quantitative RT-PCR revealed that CREB and BDNF gene expression levels were downregulated in UCMS-exposed mice, and these alterations were reversed by chronic agomelatine or melatonin treatment.	agomelatine	159-170	cAMP responsive element binding protein 1	Mus musculus	34-38
24380755-4	2014	R. rosea extract also inhibited gene and protein expression of melanocortin 1 receptor (MC1R) and inhibited c-AMP response element binding protein (CREB) phosphorylation, suppressed the activation of AKT and glycogen synthase kinase-3 beta (GSK3beta), and inhibited the expression of microphthalmia-associated transcription factor (MITF) and tyrosinase-related protein 1 (TRP-1).	c-amp	108-113	cAMP responsive element binding protein 1	Mus musculus	148-152
24716407-3	2014	Moreover, myriocin up-regulated microphthalmia-associated transcription factor (MITF) and tyrosinase expression via phosphorylation of CREB, but it did not directly activate tyrosinase, a rate-limiting melanogenic enzyme.	thermozymocidin	10-18	cAMP responsive element binding protein 1	Mus musculus	135-139
24418657-9	2014	In summary, eugenol effectively ameliorates hyperglycemia through inhibition of hepatic gluconeogenesis via modulating CAMKK-AMPK-CREB signaling pathway.	Eugenol	12-19	cAMP responsive element binding protein 1	Mus musculus	130-134
25566444-10	2014	Also, these behavioral changes were concurrent with the deficit of 5HT1A and cAMP/PKA/CREB cascade in hippocampus, which was coped with chronic exercise.	Cyclic AMP	77-81	cAMP responsive element binding protein 1	Mus musculus	86-90
25566444-11	2014	CONCLUSION: These results suggest that chronic exercise may improve the disturbance of hippocampal 5HT1A-regulated cAMP/PKA/CREB signaling in a depressed brain, thereby exerting an antidepressive action.	Cyclic AMP	115-119	cAMP responsive element binding protein 1	Mus musculus	124-128
24177210-3	2014	Wild-type mice received intracerebroventricular injection of Cav2.1 blocker (omega-agatoxin IVA, 4.0 pg/side) showed impaired extinction behavior and increased expression of CREB-dependent gene Arc in medial prefrontal cortex (mPFC).	omega-	77-83	cAMP responsive element binding protein 1	Mus musculus	174-178
24570487-1	2014	Fasting glucose homeostasis is maintained in part through cAMP (adenosine 3",5"-monophosphate)-dependent transcriptional control of hepatic gluconeogenesis by the transcription factor CREB (cAMP response element-binding protein) and its coactivator CRTC2 (CREB-regulated transcriptional coactivator 2).	Cyclic AMP	58-62	cAMP responsive element binding protein 1	Mus musculus	184-188
24570487-1	2014	Fasting glucose homeostasis is maintained in part through cAMP (adenosine 3",5"-monophosphate)-dependent transcriptional control of hepatic gluconeogenesis by the transcription factor CREB (cAMP response element-binding protein) and its coactivator CRTC2 (CREB-regulated transcriptional coactivator 2).	Cyclic AMP	58-62	cAMP responsive element binding protein 1	Mus musculus	190-227
24570487-1	2014	Fasting glucose homeostasis is maintained in part through cAMP (adenosine 3",5"-monophosphate)-dependent transcriptional control of hepatic gluconeogenesis by the transcription factor CREB (cAMP response element-binding protein) and its coactivator CRTC2 (CREB-regulated transcriptional coactivator 2).	Cyclic AMP	64-93	cAMP responsive element binding protein 1	Mus musculus	184-188
24570487-1	2014	Fasting glucose homeostasis is maintained in part through cAMP (adenosine 3",5"-monophosphate)-dependent transcriptional control of hepatic gluconeogenesis by the transcription factor CREB (cAMP response element-binding protein) and its coactivator CRTC2 (CREB-regulated transcriptional coactivator 2).	Cyclic AMP	64-93	cAMP responsive element binding protein 1	Mus musculus	190-227
24570487-4	2014	In cells, PRMT6 mediated asymmetric dimethylation of multiple arginine residues of CRTC2, which enhanced the association of CRTC2 with CREB on the promoters of gluconeogenic enzyme-encoding genes.	Arginine	62-70	cAMP responsive element binding protein 1	Mus musculus	135-139
24252179-4	2014	Upon entering the nucleus, alpha-SYN interacted with the DBH promoter region encompassing the CRE, which interfered with forskolin-induced CREB binding to the CRE region.	Colforsin	121-130	cAMP responsive element binding protein 1	Mus musculus	139-143
24265455-8	2014	Transcription of the StAR gene in response to atRA and dibutyrl-cAMP was influenced by several factors, its up-regulation being dependent on phosphorylation of cAMP response-element binding protein (CREB).	Cyclic AMP	64-68	cAMP responsive element binding protein 1	Mus musculus	160-197
24265455-8	2014	Transcription of the StAR gene in response to atRA and dibutyrl-cAMP was influenced by several factors, its up-regulation being dependent on phosphorylation of cAMP response-element binding protein (CREB).	Cyclic AMP	64-68	cAMP responsive element binding protein 1	Mus musculus	199-203
24067928-2	2014	By preventing cAMP breakdown, PDE4-Is can enhance intracellular signal transduction and increase the phosphorylation of cAMP response element-binding protein (CREB) and transcription of proteins related to synaptic plasticity and associated memory formation.	Cyclic AMP	14-18	cAMP responsive element binding protein 1	Mus musculus	120-157
24123667-6	2014	JWH-081 at higher dose impaired CaMKIV and CREB phosphorylation in a time-dependent manner in CB1 receptor WT mice but not in KO mice and failed to alter ERK1/2 phosphorylation.	(4-methoxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone	0-7	cAMP responsive element binding protein 1	Mus musculus	43-47
24123667-10	2014	Collectively our findings suggest that deleterious effects of JWH-081 on hippocampal function involves CB1 receptor mediated impairments in CaMKIV and CREB phosphorylation, LTP, learning and memory in mice.	(4-methoxy-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)methanone	62-69	cAMP responsive element binding protein 1	Mus musculus	151-155
24067928-2	2014	By preventing cAMP breakdown, PDE4-Is can enhance intracellular signal transduction and increase the phosphorylation of cAMP response element-binding protein (CREB) and transcription of proteins related to synaptic plasticity and associated memory formation.	Cyclic AMP	14-18	cAMP responsive element binding protein 1	Mus musculus	159-163
24295774-5	2014	We observed that subchronic peroral exposure to TiO2 NPs caused severe pathological changes, spatial recognition impairment, and resulted in significant LTP reduction and down-regulation of N-methyl-D-aspartate (NMDA) receptor subunits (NR2A and NR2B) expression associated with the simultaneous inhibition of CaMKIV, cyclic-AMP responsive element binding proteins (CREB-1, CREB-2), and FosB/DFosB in mouse hippocampal tissues.	titanium dioxide	48-52	cAMP responsive element binding protein 1	Mus musculus	366-372
24184387-5	2014	The increased p-ERK further phosphorylated the cAMP response element-binding protein (p-CREB) which in turn may have resulted in the increased mitogen activated protein kinase (MAPK) phosphatase 1 (MKP1), known to dephosphorylate MAPKs.	Cyclic AMP	47-51	cAMP responsive element binding protein 1	Mus musculus	88-92
24269729-7	2014	In YAC128 mice, memantine at 1mg/kg/day rescued CREB shut-off, while both doses suppressed p38 MAPK activation to WT levels.	Memantine	16-25	cAMP responsive element binding protein 1	Mus musculus	48-52
24338011-6	2014	Additionally, the Panx3 hemichannel inhibited cyclin D1 transcription and Rb phosphorylation through reduced cAMP/PKA/CREB signaling.	hemichannel	24-35	cAMP responsive element binding protein 1	Mus musculus	118-122
24338011-6	2014	Additionally, the Panx3 hemichannel inhibited cyclin D1 transcription and Rb phosphorylation through reduced cAMP/PKA/CREB signaling.	Cyclic AMP	109-113	cAMP responsive element binding protein 1	Mus musculus	118-122
24354358-3	2014	BA activated AMPK and suppressed the expression level of phosphorylated CREB.	betulinic acid	0-2	cAMP responsive element binding protein 1	Mus musculus	72-76
24354358-10	2014	In summary, BA effectively ameliorates hyperglycemia through inhibition of hepatic gluconeogenesis via modulating the CAMKK-AMPK-CREB signaling pathway.	betulinic acid	12-14	cAMP responsive element binding protein 1	Mus musculus	129-133
23682813-5	2014	Furthermore, NaHS also attenuated morphine/naloxone-elevated mRNA levels of AC isoform 1 and 8, production of cAMP, and phosphorylation of cAMP response element-binding protein (CREB) in mice striatum.	sodium bisulfide	13-17	cAMP responsive element binding protein 1	Mus musculus	139-176
24333333-8	2014	Cilostazol in fact enhanced expression of p-CREB, which was inhibited by H-89.	Cilostazol	0-10	cAMP responsive element binding protein 1	Mus musculus	44-48
24333333-9	2014	Moreover, this cilostazol-induced increase in expression of MITF was inhibited by downregulation of CREB using CREB siRNA.	Cilostazol	15-25	cAMP responsive element binding protein 1	Mus musculus	100-104
24333333-9	2014	Moreover, this cilostazol-induced increase in expression of MITF was inhibited by downregulation of CREB using CREB siRNA.	Cilostazol	15-25	cAMP responsive element binding protein 1	Mus musculus	111-115
24333333-10	2014	These data suggest that induction of MITF via the PKA/CREB pathway plays a critical role in cilostazol-induced production of melanin in B16-F10 melanoma cells.	Cilostazol	92-102	cAMP responsive element binding protein 1	Mus musculus	54-58
24333333-10	2014	These data suggest that induction of MITF via the PKA/CREB pathway plays a critical role in cilostazol-induced production of melanin in B16-F10 melanoma cells.	Melanins	125-132	cAMP responsive element binding protein 1	Mus musculus	54-58
24036107-7	2014	Co-administration of 9h of fasting and imipramine (30mg/kg, i.p) produced the additive antidepressant-like effects in the FST and increased the ratio of p-CREB/CREB.	Imipramine	39-49	cAMP responsive element binding protein 1	Mus musculus	155-159
24036107-7	2014	Co-administration of 9h of fasting and imipramine (30mg/kg, i.p) produced the additive antidepressant-like effects in the FST and increased the ratio of p-CREB/CREB.	Imipramine	39-49	cAMP responsive element binding protein 1	Mus musculus	160-164
23682813-5	2014	Furthermore, NaHS also attenuated morphine/naloxone-elevated mRNA levels of AC isoform 1 and 8, production of cAMP, and phosphorylation of cAMP response element-binding protein (CREB) in mice striatum.	sodium bisulfide	13-17	cAMP responsive element binding protein 1	Mus musculus	178-182
23682813-5	2014	Furthermore, NaHS also attenuated morphine/naloxone-elevated mRNA levels of AC isoform 1 and 8, production of cAMP, and phosphorylation of cAMP response element-binding protein (CREB) in mice striatum.	Morphine	34-42	cAMP responsive element binding protein 1	Mus musculus	139-176
23682813-5	2014	Furthermore, NaHS also attenuated morphine/naloxone-elevated mRNA levels of AC isoform 1 and 8, production of cAMP, and phosphorylation of cAMP response element-binding protein (CREB) in mice striatum.	Morphine	34-42	cAMP responsive element binding protein 1	Mus musculus	178-182
23682813-5	2014	Furthermore, NaHS also attenuated morphine/naloxone-elevated mRNA levels of AC isoform 1 and 8, production of cAMP, and phosphorylation of cAMP response element-binding protein (CREB) in mice striatum.	Naloxone	43-51	cAMP responsive element binding protein 1	Mus musculus	139-176
23682813-5	2014	Furthermore, NaHS also attenuated morphine/naloxone-elevated mRNA levels of AC isoform 1 and 8, production of cAMP, and phosphorylation of cAMP response element-binding protein (CREB) in mice striatum.	Naloxone	43-51	cAMP responsive element binding protein 1	Mus musculus	178-182
23682813-7	2014	Blockade of extracellular-regulated protein kinase 1/2 (ERK1/2) with its specific inhibitor attenuated naloxone-induced CREB phosphorylation.	Naloxone	103-111	cAMP responsive element binding protein 1	Mus musculus	120-124
24022402-1	2014	The transcription factors cAMP-responsive element binding protein (CREB) and cAMP-responsive element modulator (CREM) regulate gene transcription in response to elevated cAMP levels.	Cyclic AMP	26-30	cAMP responsive element binding protein 1	Mus musculus	67-71
25031604-7	2014	Interestingly, the level of CREB phosphorylation and BDNF expression in hippocampal tissue of scopolamine-treated mice was significantly increased by the administration of fermented C. lanceolata.	Scopolamine	94-105	cAMP responsive element binding protein 1	Mus musculus	28-32
24349326-10	2013	Our in vivo data demonstrate that sitagliptin treatment phosphorylated CREB and induced islet vascularization through VEGF-A/VEGFR-2 signaling pathway.	Sitagliptin Phosphate	34-45	cAMP responsive element binding protein 1	Mus musculus	71-75
24035379-13	2014	Thus, alpha-2a receptor agonism-induced CREB phosphorylation and contributes to dexmedetomidine"s protective mechanism in the spinal cord following ischemia.	Dexmedetomidine	80-95	cAMP responsive element binding protein 1	Mus musculus	40-44
24379765-3	2013	In the present work, we investigated the effects of acute and repeated ethanol administration on cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) DNA-binding activity using the electrophoretic mobility shift assay (EMSA) and the phosphorylated CREB (pCREB)/CREB ratio using immunoblotting in both the PFC and hippocampus in adolescent and adult mice.	Cyclic AMP	129-133	cAMP responsive element binding protein 1	Mus musculus	273-277
24379765-3	2013	In the present work, we investigated the effects of acute and repeated ethanol administration on cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) DNA-binding activity using the electrophoretic mobility shift assay (EMSA) and the phosphorylated CREB (pCREB)/CREB ratio using immunoblotting in both the PFC and hippocampus in adolescent and adult mice.	Cyclic AMP	129-133	cAMP responsive element binding protein 1	Mus musculus	273-277
24379765-6	2013	The present results indicate that ethanol exposure induces significant and differential neuroadaptive changes in CREB DNA-binding activity in the PFC and hippocampus in adolescent mice compared with adult mice.	Ethanol	34-41	cAMP responsive element binding protein 1	Mus musculus	113-117
24370585-5	2014	Rosi also increases the intracellular cAMP and expression of both protein kinase A (PKA) and cAMP response element binding protein (CREB).	Rosiglitazone	0-4	cAMP responsive element binding protein 1	Mus musculus	93-130
24370585-5	2014	Rosi also increases the intracellular cAMP and expression of both protein kinase A (PKA) and cAMP response element binding protein (CREB).	Rosiglitazone	0-4	cAMP responsive element binding protein 1	Mus musculus	132-136
24379765-0	2013	Changes in CREB activation in the prefrontal cortex and hippocampus blunt ethanol-induced behavioral sensitization in adolescent mice.	Ethanol	74-81	cAMP responsive element binding protein 1	Mus musculus	11-15
24379765-3	2013	In the present work, we investigated the effects of acute and repeated ethanol administration on cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) DNA-binding activity using the electrophoretic mobility shift assay (EMSA) and the phosphorylated CREB (pCREB)/CREB ratio using immunoblotting in both the PFC and hippocampus in adolescent and adult mice.	Ethanol	71-78	cAMP responsive element binding protein 1	Mus musculus	169-173
24379765-3	2013	In the present work, we investigated the effects of acute and repeated ethanol administration on cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) DNA-binding activity using the electrophoretic mobility shift assay (EMSA) and the phosphorylated CREB (pCREB)/CREB ratio using immunoblotting in both the PFC and hippocampus in adolescent and adult mice.	Ethanol	71-78	cAMP responsive element binding protein 1	Mus musculus	273-277
24379765-3	2013	In the present work, we investigated the effects of acute and repeated ethanol administration on cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) DNA-binding activity using the electrophoretic mobility shift assay (EMSA) and the phosphorylated CREB (pCREB)/CREB ratio using immunoblotting in both the PFC and hippocampus in adolescent and adult mice.	Ethanol	71-78	cAMP responsive element binding protein 1	Mus musculus	273-277
24379765-3	2013	In the present work, we investigated the effects of acute and repeated ethanol administration on cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) DNA-binding activity using the electrophoretic mobility shift assay (EMSA) and the phosphorylated CREB (pCREB)/CREB ratio using immunoblotting in both the PFC and hippocampus in adolescent and adult mice.	Cyclic AMP	97-127	cAMP responsive element binding protein 1	Mus musculus	169-173
24379765-3	2013	In the present work, we investigated the effects of acute and repeated ethanol administration on cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) DNA-binding activity using the electrophoretic mobility shift assay (EMSA) and the phosphorylated CREB (pCREB)/CREB ratio using immunoblotting in both the PFC and hippocampus in adolescent and adult mice.	Cyclic AMP	97-127	cAMP responsive element binding protein 1	Mus musculus	273-277
24379765-3	2013	In the present work, we investigated the effects of acute and repeated ethanol administration on cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) DNA-binding activity using the electrophoretic mobility shift assay (EMSA) and the phosphorylated CREB (pCREB)/CREB ratio using immunoblotting in both the PFC and hippocampus in adolescent and adult mice.	Cyclic AMP	97-127	cAMP responsive element binding protein 1	Mus musculus	273-277
24379765-3	2013	In the present work, we investigated the effects of acute and repeated ethanol administration on cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB) DNA-binding activity using the electrophoretic mobility shift assay (EMSA) and the phosphorylated CREB (pCREB)/CREB ratio using immunoblotting in both the PFC and hippocampus in adolescent and adult mice.	Cyclic AMP	129-133	cAMP responsive element binding protein 1	Mus musculus	169-173
24100253-8	2013	In HL-1 cells, pioglitazone suppressed AngII-induced ICa-L alpha1c expression and current density as well as CAMP responsive element binding protein (CREB) phosphorylation.	Pioglitazone	15-27	cAMP responsive element binding protein 1	Mus musculus	109-148
24340001-5	2013	In response to stimulation with the non-selective beta-AR agonist isoproterenol, we observed previously described phosphorylation events such as ERK1/2(T202/Y204) and CREB(S133), but also novel phosphorylation events such as Cdc2(Y15) and Pyk2(Y402).	Isoproterenol	66-79	cAMP responsive element binding protein 1	Mus musculus	167-171
24325567-7	2013	Moreover, our result also first found that norartocarpetin downregulated phospho-cAMP response element-binding (phospho-CREB) and microphthalmia-associated transcription factor (MITF) expression, which in turn decreased both synthesis of tyrosinases (TRP-1 and TRP-2) and cellular melanin content.	Norartocarpetin	43-58	cAMP responsive element binding protein 1	Mus musculus	120-124
24325567-7	2013	Moreover, our result also first found that norartocarpetin downregulated phospho-cAMP response element-binding (phospho-CREB) and microphthalmia-associated transcription factor (MITF) expression, which in turn decreased both synthesis of tyrosinases (TRP-1 and TRP-2) and cellular melanin content.	Cyclic AMP	81-85	cAMP responsive element binding protein 1	Mus musculus	120-124
24085036-6	2013	Mice treated with GLP-1(28-36)amide exhibited increased phosphorylation of PKA targets, including cAMP response element-binding protein (CREB), ATF-1, and beta-catenin.	Amides	30-35	cAMP responsive element binding protein 1	Mus musculus	98-135
24085036-6	2013	Mice treated with GLP-1(28-36)amide exhibited increased phosphorylation of PKA targets, including cAMP response element-binding protein (CREB), ATF-1, and beta-catenin.	Amides	30-35	cAMP responsive element binding protein 1	Mus musculus	137-141
24100253-11	2013	Moreover, pioglitazone also attenuates AngII-induced ICa-L remodeling in HL-1 cells, which might be at least in part associated with its inhibitory effect on CREB phosphorylation.	Pioglitazone	10-22	cAMP responsive element binding protein 1	Mus musculus	158-162
24100927-5	2013	Therefore, in this study we assessed whether phosphorylation levels of several MAPKs, Akt and CREB were differentially affected by PA in both wild-type (WT) and D 3 (-/-) mice hippocampi.	Protactinium	131-133	cAMP responsive element binding protein 1	Mus musculus	94-98
24123152-0	2013	Tyrosine phosphatase STEP61 negatively regulates amyloid beta-mediated ERK/CREB signaling pathways via alpha7 nicotinic acetylcholine receptors.	Acetylcholine	120-133	cAMP responsive element binding protein 1	Mus musculus	75-79
24100927-12	2013	In conclusion, these data supports the notion that D3Rs might modulate CREB phosphorylation after acquisition of PA, probably via activation of ERK signaling.	Protactinium	113-115	cAMP responsive element binding protein 1	Mus musculus	71-75
24126911-5	2013	Rapamycin treatment led to phosphorylation of CREB, transcription factor 1 (ATF1), and ATF2, three transcription factors that bind to the cyclic AMP-responsive elements on the Mkp-1 promoter.	Sirolimus	0-9	cAMP responsive element binding protein 1	Mus musculus	46-50
24225056-0	2013	Effects of carvedilol treatment on cardiac cAMP response element binding protein expression and phosphorylation in acute coxsackievirus B3-induced myocarditis.	Carvedilol	11-21	cAMP responsive element binding protein 1	Mus musculus	43-80
24126911-5	2013	Rapamycin treatment led to phosphorylation of CREB, transcription factor 1 (ATF1), and ATF2, three transcription factors that bind to the cyclic AMP-responsive elements on the Mkp-1 promoter.	Cyclic AMP	138-148	cAMP responsive element binding protein 1	Mus musculus	46-50
24225056-2	2013	Excess stimulation of beta-adrenergic receptors by catecholamines causes phosphorylation/activation of cAMP response element binding protein (CREB) by the cAMP signaling pathway.	Catecholamines	51-65	cAMP responsive element binding protein 1	Mus musculus	103-140
24225056-2	2013	Excess stimulation of beta-adrenergic receptors by catecholamines causes phosphorylation/activation of cAMP response element binding protein (CREB) by the cAMP signaling pathway.	Catecholamines	51-65	cAMP responsive element binding protein 1	Mus musculus	142-146
24225056-2	2013	Excess stimulation of beta-adrenergic receptors by catecholamines causes phosphorylation/activation of cAMP response element binding protein (CREB) by the cAMP signaling pathway.	Cyclic AMP	103-107	cAMP responsive element binding protein 1	Mus musculus	142-146
24225056-4	2013	However, the CREB expression and phosphorylation have not been studied, and the effects of carvedilol (a nonselective beta-adrenoceptor antagonist) on the CREB has not been investigated in the setting of acute viral myocarditis.	Carvedilol	91-101	cAMP responsive element binding protein 1	Mus musculus	155-159
24225056-5	2013	METHODS: This study was therefore designed to examine the effects of carvedilol on the transcriptional factor CREB in a murine model of acute viral myocarditis.	Carvedilol	69-79	cAMP responsive element binding protein 1	Mus musculus	110-114
24225056-9	2013	Carvedilol increased the cardiac CREB expression and phosphorylation and decreased the plasma catecholamine levels and the production of IL-6 and TNF-alpha with amelioration of acute viral myocarditis.	Carvedilol	0-10	cAMP responsive element binding protein 1	Mus musculus	33-37
24225056-10	2013	CONCLUSION: These results show that CREB may be involved in the pathophysiology of viral myocarditis and carvedilol exerts some of its beneficial effects by increasing the CREB expression and phosphorylation.	Carvedilol	105-115	cAMP responsive element binding protein 1	Mus musculus	172-176
23816950-1	2013	UNLABELLED: The effect of long-term administration of imipramine, a tricyclic antidepressant, on the phosphorylation status of cyclic adenosine monophosphate-responsive element-binding protein (CREB), mitogen-activated protein kinase family members, and phospholipase gamma-1 (PLCgamma-1) was investigated in the dorsal horn of the spinal cord following peripheral nerve lesion.	Imipramine	54-64	cAMP responsive element binding protein 1	Mus musculus	127-192
24147136-8	2013	CREB and its co-activator CRTC2, both activated by fasting stimuli, contribute to glucagon-stimulated Nedd4l-short expression in primary hepatocytes.	Glucagon	82-90	cAMP responsive element binding protein 1	Mus musculus	0-4
23973607-7	2013	In conclusion, our results suggested for the first time that tyrosine phosphorylation of PDK1 is required for PKB and CREB activation in KA-mediated excitotoxic lesion in mouse brain.	Tyrosine	61-69	cAMP responsive element binding protein 1	Mus musculus	118-122
24404337-8	2013	EUE also markedly increased brain-derived neurotrophic factor (BDNF) and phosphorylation of cAMP element binding protein (CREB) in the hippocampus of scopolamine-induced mice.	Cyclic AMP	92-96	cAMP responsive element binding protein 1	Mus musculus	122-126
24404337-8	2013	EUE also markedly increased brain-derived neurotrophic factor (BDNF) and phosphorylation of cAMP element binding protein (CREB) in the hippocampus of scopolamine-induced mice.	Scopolamine	150-161	cAMP responsive element binding protein 1	Mus musculus	122-126
24205196-0	2013	Enhancement of behavioral sensitization, anxiety-like behavior, and hippocampal and frontal cortical CREB levels following cocaine abstinence in mice exposed to cocaine during adolescence.	Cocaine	123-130	cAMP responsive element binding protein 1	Mus musculus	101-105
24205196-0	2013	Enhancement of behavioral sensitization, anxiety-like behavior, and hippocampal and frontal cortical CREB levels following cocaine abstinence in mice exposed to cocaine during adolescence.	Cocaine	161-168	cAMP responsive element binding protein 1	Mus musculus	101-105
24205196-2	2013	Decreases in cyclic adenosine monophosphate response element binding protein (CREB) and phosphorylated CREB (pCREB) have been reported after repeated cocaine administration in animal models.	Cyclic AMP	13-43	cAMP responsive element binding protein 1	Mus musculus	78-82
24205196-2	2013	Decreases in cyclic adenosine monophosphate response element binding protein (CREB) and phosphorylated CREB (pCREB) have been reported after repeated cocaine administration in animal models.	Cocaine	150-157	cAMP responsive element binding protein 1	Mus musculus	78-82
24205196-2	2013	Decreases in cyclic adenosine monophosphate response element binding protein (CREB) and phosphorylated CREB (pCREB) have been reported after repeated cocaine administration in animal models.	Cocaine	150-157	cAMP responsive element binding protein 1	Mus musculus	103-107
24205196-11	2013	Significant increases in CREB levels in the PFC and hippocampus and pCREB in the hippocampus were observed in cocaine-abstinent animals compared with the animals treated with cocaine in adulthood.	Cocaine	110-117	cAMP responsive element binding protein 1	Mus musculus	25-29
24205196-11	2013	Significant increases in CREB levels in the PFC and hippocampus and pCREB in the hippocampus were observed in cocaine-abstinent animals compared with the animals treated with cocaine in adulthood.	Cocaine	175-182	cAMP responsive element binding protein 1	Mus musculus	25-29
24205196-12	2013	Interestingly, significant negative correlations were observed between cocaine sensitization and CREB levels in both regions.	Cocaine	71-78	cAMP responsive element binding protein 1	Mus musculus	97-101
23812774-6	2013	Western blotting showed that tyrosinase inhibition by MHY498 partly resulted from the expressional modulations of tyrosinase and its transcription factor, microphthalmia-associated transcription factor, via the cAMP-PKA-CREB pathway.	(Z)-5-(2,4-dihydroxybenzylidene)thiazolidine-2,4-dione	54-60	cAMP responsive element binding protein 1	Mus musculus	220-224
23812774-6	2013	Western blotting showed that tyrosinase inhibition by MHY498 partly resulted from the expressional modulations of tyrosinase and its transcription factor, microphthalmia-associated transcription factor, via the cAMP-PKA-CREB pathway.	Cyclic AMP	211-215	cAMP responsive element binding protein 1	Mus musculus	220-224
23745716-5	2013	Morphine exposure induced an increase in CREB phosphorylated at Ser133 in the PVN and central amygdale (CeA), whereas mice exhibiting morphine CPP had higher levels of pCREB in the PVN, CeA and bed nucleus of the stria terminalis (BNST).	Morphine	0-8	cAMP responsive element binding protein 1	Mus musculus	41-45
24051374-2	2013	Glucagon triggering of the cAMP pathway upregulates the gluconeogenic program through the phosphorylation of cAMP response element-binding protein (CREB) and the dephosphorylation of the CREB coactivator CRTC2.	Cyclic AMP	27-31	cAMP responsive element binding protein 1	Mus musculus	109-146
24051374-2	2013	Glucagon triggering of the cAMP pathway upregulates the gluconeogenic program through the phosphorylation of cAMP response element-binding protein (CREB) and the dephosphorylation of the CREB coactivator CRTC2.	Cyclic AMP	27-31	cAMP responsive element binding protein 1	Mus musculus	148-152
24051374-2	2013	Glucagon triggering of the cAMP pathway upregulates the gluconeogenic program through the phosphorylation of cAMP response element-binding protein (CREB) and the dephosphorylation of the CREB coactivator CRTC2.	Cyclic AMP	27-31	cAMP responsive element binding protein 1	Mus musculus	187-191
23208771-6	2013	Furthermore, by evaluating the melanogenic proteins, we found that the cells treated with 4"-O-methylated flavonoids showed higher tyrosinase activity, as well as upregulation of tyrosinase expression, preceded by activation of cAMP response element binding protein (CREB) and extracellular signal-regulated kinases types 1 and 2 (ERK1/2).	4"-o	90-94	cAMP responsive element binding protein 1	Mus musculus	228-265
23208771-6	2013	Furthermore, by evaluating the melanogenic proteins, we found that the cells treated with 4"-O-methylated flavonoids showed higher tyrosinase activity, as well as upregulation of tyrosinase expression, preceded by activation of cAMP response element binding protein (CREB) and extracellular signal-regulated kinases types 1 and 2 (ERK1/2).	4"-o	90-94	cAMP responsive element binding protein 1	Mus musculus	267-271
23208771-6	2013	Furthermore, by evaluating the melanogenic proteins, we found that the cells treated with 4"-O-methylated flavonoids showed higher tyrosinase activity, as well as upregulation of tyrosinase expression, preceded by activation of cAMP response element binding protein (CREB) and extracellular signal-regulated kinases types 1 and 2 (ERK1/2).	Flavonoids	106-116	cAMP responsive element binding protein 1	Mus musculus	228-265
23208771-6	2013	Furthermore, by evaluating the melanogenic proteins, we found that the cells treated with 4"-O-methylated flavonoids showed higher tyrosinase activity, as well as upregulation of tyrosinase expression, preceded by activation of cAMP response element binding protein (CREB) and extracellular signal-regulated kinases types 1 and 2 (ERK1/2).	Flavonoids	106-116	cAMP responsive element binding protein 1	Mus musculus	267-271
23208771-7	2013	These results indicate that the 4"-O-methyl group of flavonoids plays an important role in the induction of melanogenesis by activating its major signal transduction pathway through the upregulation of phospho-CREB in murine B16F10 melanoma cells.	Flavonoids	53-63	cAMP responsive element binding protein 1	Mus musculus	210-214
23816950-1	2013	UNLABELLED: The effect of long-term administration of imipramine, a tricyclic antidepressant, on the phosphorylation status of cyclic adenosine monophosphate-responsive element-binding protein (CREB), mitogen-activated protein kinase family members, and phospholipase gamma-1 (PLCgamma-1) was investigated in the dorsal horn of the spinal cord following peripheral nerve lesion.	Imipramine	54-64	cAMP responsive element binding protein 1	Mus musculus	194-198
23816950-6	2013	Moreover, imipramine therapy reversed nerve injury-induced CREB and PLCgamma-1 phosphorylation but had no effect on ERK1,2, p38, and c-Jun N-terminal kinase activity.	Imipramine	10-20	cAMP responsive element binding protein 1	Mus musculus	59-63
23816950-9	2013	Our data also provide evidence that prolonged imipramine treatment may induce antinociception in neuropathic pain conditions because of its action on the PLCgamma-1/CREB-signaling pathway.	Imipramine	46-56	cAMP responsive element binding protein 1	Mus musculus	165-169
23712033-4	2013	Instead of directly interacting with PPARgamma, A2AR stimulated PPARgamma expression via protein kinase A (PKA)-cAMP response element binding protein (CREB) signaling by provoking the binding of CREB to a cAMP responsive element (CRE)-like site in PPARgamma gene promoter region.	Cyclic AMP	112-116	cAMP responsive element binding protein 1	Mus musculus	151-155
24045154-3	2013	ROS production led to the Syk-, Pyk2-, and mitogen-activated protein kinase (MAPK)-dependent production of the proinflammatory cytokine interleukin-17A (IL-17A) in a manner that required the transcription factor CREB (cyclic adenosine monophosphate response element-binding protein).	Reactive Oxygen Species	0-3	cAMP responsive element binding protein 1	Mus musculus	212-216
23712033-4	2013	Instead of directly interacting with PPARgamma, A2AR stimulated PPARgamma expression via protein kinase A (PKA)-cAMP response element binding protein (CREB) signaling by provoking the binding of CREB to a cAMP responsive element (CRE)-like site in PPARgamma gene promoter region.	Cyclic AMP	112-116	cAMP responsive element binding protein 1	Mus musculus	195-199
23712033-4	2013	Instead of directly interacting with PPARgamma, A2AR stimulated PPARgamma expression via protein kinase A (PKA)-cAMP response element binding protein (CREB) signaling by provoking the binding of CREB to a cAMP responsive element (CRE)-like site in PPARgamma gene promoter region.	Cyclic AMP	205-209	cAMP responsive element binding protein 1	Mus musculus	151-155
23712033-4	2013	Instead of directly interacting with PPARgamma, A2AR stimulated PPARgamma expression via protein kinase A (PKA)-cAMP response element binding protein (CREB) signaling by provoking the binding of CREB to a cAMP responsive element (CRE)-like site in PPARgamma gene promoter region.	Cyclic AMP	205-209	cAMP responsive element binding protein 1	Mus musculus	195-199
23912595-4	2013	Moreover, decreased A2AR function is associated with decreased CREB activity in the DMS, which enhances goal-oriented behaviors and contributes to excessive ethanol drinking in mice.	Ethanol	157-164	cAMP responsive element binding protein 1	Mus musculus	63-67
23746756-6	2013	Intraperitoneal administration of OMT decreased the mean IOD of NR2B in the dorsal horn and expression of NR2B, p-ERK and p-CREB protein.	omt	34-37	cAMP responsive element binding protein 1	Mus musculus	124-128
23972989-2	2013	Here, we provide evidence that PPARalpha is constitutively expressed in nuclei of hippocampal neurons and, surprisingly, controls calcium influx and the expression of various plasticity-related genes via direct transcriptional regulation of cyclic AMP response element binding (CREB).	Cyclic AMP	241-251	cAMP responsive element binding protein 1	Mus musculus	278-282
23966081-9	2013	In addition, apigenin restored neurotrophic ERK/CREB/BDNF pathway in the cerebral cortex.	Apigenin	13-21	cAMP responsive element binding protein 1	Mus musculus	48-52
23966081-10	2013	In conclusion, apigenin may ameliorate AD-associated learning and memory impairment through relieving Abeta burden, suppressing amyloidogenic process, inhibiting oxidative stress, and restoring ERK/CREB/BDNF pathway.	Apigenin	15-23	cAMP responsive element binding protein 1	Mus musculus	198-202
23746756-0	2013	Antinociceptive effects of oxymatrine from Sophora flavescens, through regulation of NR2B-containing NMDA receptor-ERK/CREB signaling in a mice model of neuropathic pain.	oxymatrine	27-37	cAMP responsive element binding protein 1	Mus musculus	119-123
23746756-1	2013	PURPOSE: In this study we investigated antinociceptive effects of oxymatrine through regulation of NR2B-containing NMDA receptor-ERK/CREB signaling in a chronic neuropathic pain model induced by chronic constrictive injury (CCI) of the sciatic nerve.	oxymatrine	66-76	cAMP responsive element binding protein 1	Mus musculus	133-137
23500140-6	2013	High glucose also increased UCHL5 protein expression, which was attenuated by LY294002, the dominant-negative p85 and the dominant-negative CREB.	Glucose	5-12	cAMP responsive element binding protein 1	Mus musculus	140-144
23624148-8	2013	Moreover, sciadopitysin increased phosphorylation of cAMP-response element-binding protein (CREB) inhibited by antimycin A.	Antimycin A	111-122	cAMP responsive element binding protein 1	Mus musculus	53-90
23624148-8	2013	Moreover, sciadopitysin increased phosphorylation of cAMP-response element-binding protein (CREB) inhibited by antimycin A.	Antimycin A	111-122	cAMP responsive element binding protein 1	Mus musculus	92-96
23760271-4	2013	Basal and NMDA-induced phosphorylation of the transcription factor cAMP-response element-binding protein (CREB) as well as NMDA target gene transcription are reduced in LRP1-deficient neurons.	N-Methylaspartate	10-14	cAMP responsive element binding protein 1	Mus musculus	67-104
23760271-4	2013	Basal and NMDA-induced phosphorylation of the transcription factor cAMP-response element-binding protein (CREB) as well as NMDA target gene transcription are reduced in LRP1-deficient neurons.	N-Methylaspartate	10-14	cAMP responsive element binding protein 1	Mus musculus	106-110
23967086-6	2013	In vitro studies using primary hepatocyte cultures treated with epinephrine or AR-agonists confirmed that hepatic AR/cAMP/PKA/CREB- and JNK-linked pathways are involved in PPARalpha and HNF4alpha regulation.	Epinephrine	64-75	cAMP responsive element binding protein 1	Mus musculus	126-130
23967086-6	2013	In vitro studies using primary hepatocyte cultures treated with epinephrine or AR-agonists confirmed that hepatic AR/cAMP/PKA/CREB- and JNK-linked pathways are involved in PPARalpha and HNF4alpha regulation.	Cyclic AMP	117-121	cAMP responsive element binding protein 1	Mus musculus	126-130
23855546-9	2013	Western blot analysis showed that QE increased the phosphorylations of Akt, CaMKII nNOS, eNOS, and CREB in brains of Pb-treated mice.	Lead	117-119	cAMP responsive element binding protein 1	Mus musculus	99-103
23688860-4	2013	Among its active flavonoids, fisetin exhibited not only inhibitory effect against lipopolysaccharide (LPS)-induced neuroinflammation by suppressing inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 but also memory enhancing effects via reactivation of cAMP responsive element binding protein (CREB)-brain derived neurotrophic factor (BDNF) pathway in memory-impaired mice by scopolamine.	fisetin	29-36	cAMP responsive element binding protein 1	Mus musculus	268-307
23688860-4	2013	Among its active flavonoids, fisetin exhibited not only inhibitory effect against lipopolysaccharide (LPS)-induced neuroinflammation by suppressing inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 but also memory enhancing effects via reactivation of cAMP responsive element binding protein (CREB)-brain derived neurotrophic factor (BDNF) pathway in memory-impaired mice by scopolamine.	fisetin	29-36	cAMP responsive element binding protein 1	Mus musculus	309-313
23826796-6	2013	Suppressing PDE4D activity with Rolipram in turn restores the down-stream phosphorylation of the "cAMP response element-binding protein" (CREB) that is defective in mouse mutant cells.	Rolipram	32-40	cAMP responsive element binding protein 1	Mus musculus	138-142
23826796-6	2013	Suppressing PDE4D activity with Rolipram in turn restores the down-stream phosphorylation of the "cAMP response element-binding protein" (CREB) that is defective in mouse mutant cells.	Cyclic AMP	98-102	cAMP responsive element binding protein 1	Mus musculus	138-142
23826796-9	2013	Based on our in vitro evidence we propose a model which links CC2D1A structure and function to cAMP homeostasis thereby affecting CREB phosphorylation.	Cyclic AMP	95-99	cAMP responsive element binding protein 1	Mus musculus	130-134
23523934-3	2013	Treatment with 1mM H2O2 increased the cellular melanin content; the expression of PAH, TYR, and MITF; and the phosphorylation of CREB in B16F10 and SK-Mel-2 cells.	Hydrogen Peroxide	19-23	cAMP responsive element binding protein 1	Mus musculus	129-133
23653362-6	2013	The activation of cAMP-response element-binding protein (CREB), but not NF-kappaB, by aspirin, the abrogation of aspirin-induced expression of CNTF by siRNA knockdown of CREB, the presence of a consensus cAMP-response element in the promoter of CNTF, and the recruitment of CREB and CREB-binding protein to the CNTF promoter by aspirin suggest that aspirin increases the expression of the Cntf gene via the activation of CREB.	Aspirin	113-120	cAMP responsive element binding protein 1	Mus musculus	170-174
23389690-8	2013	Furthermore, AG significantly inhibited the attenuating effects of McN on decreased NMDAR-dependent LTP, protein kinase C betaII, p-ERK, p-CREB, BDNF, and p-JAK2/p-STAT3-expression in klotho mutant mice.	mcn	67-70	cAMP responsive element binding protein 1	Mus musculus	139-143
23633027-7	2013	The increase of NR1 and NR2B subunits of the NMDAR was significantly diminished by intrathecal administration of the CREB antisense oligonucleotide against CREB and pCREB.	Oligonucleotides	132-147	cAMP responsive element binding protein 1	Mus musculus	117-121
23633027-7	2013	The increase of NR1 and NR2B subunits of the NMDAR was significantly diminished by intrathecal administration of the CREB antisense oligonucleotide against CREB and pCREB.	Oligonucleotides	132-147	cAMP responsive element binding protein 1	Mus musculus	156-160
23633027-8	2013	Additionally, nociceptive behavior induced by CCI was attenuated by intrathecal administration of the CREB antisense oligonucleotide during the period of injection, and the above effects of relieving pain lasted at least 12 days following the last injection.	CCI	46-49	cAMP responsive element binding protein 1	Mus musculus	102-106
23633027-8	2013	Additionally, nociceptive behavior induced by CCI was attenuated by intrathecal administration of the CREB antisense oligonucleotide during the period of injection, and the above effects of relieving pain lasted at least 12 days following the last injection.	Oligonucleotides	117-132	cAMP responsive element binding protein 1	Mus musculus	102-106
23653362-6	2013	The activation of cAMP-response element-binding protein (CREB), but not NF-kappaB, by aspirin, the abrogation of aspirin-induced expression of CNTF by siRNA knockdown of CREB, the presence of a consensus cAMP-response element in the promoter of CNTF, and the recruitment of CREB and CREB-binding protein to the CNTF promoter by aspirin suggest that aspirin increases the expression of the Cntf gene via the activation of CREB.	Aspirin	86-93	cAMP responsive element binding protein 1	Mus musculus	18-55
23653362-6	2013	The activation of cAMP-response element-binding protein (CREB), but not NF-kappaB, by aspirin, the abrogation of aspirin-induced expression of CNTF by siRNA knockdown of CREB, the presence of a consensus cAMP-response element in the promoter of CNTF, and the recruitment of CREB and CREB-binding protein to the CNTF promoter by aspirin suggest that aspirin increases the expression of the Cntf gene via the activation of CREB.	Aspirin	86-93	cAMP responsive element binding protein 1	Mus musculus	57-61
23653362-6	2013	The activation of cAMP-response element-binding protein (CREB), but not NF-kappaB, by aspirin, the abrogation of aspirin-induced expression of CNTF by siRNA knockdown of CREB, the presence of a consensus cAMP-response element in the promoter of CNTF, and the recruitment of CREB and CREB-binding protein to the CNTF promoter by aspirin suggest that aspirin increases the expression of the Cntf gene via the activation of CREB.	Aspirin	113-120	cAMP responsive element binding protein 1	Mus musculus	18-55
23653362-6	2013	The activation of cAMP-response element-binding protein (CREB), but not NF-kappaB, by aspirin, the abrogation of aspirin-induced expression of CNTF by siRNA knockdown of CREB, the presence of a consensus cAMP-response element in the promoter of CNTF, and the recruitment of CREB and CREB-binding protein to the CNTF promoter by aspirin suggest that aspirin increases the expression of the Cntf gene via the activation of CREB.	Cyclic AMP	18-22	cAMP responsive element binding protein 1	Mus musculus	57-61
23653362-6	2013	The activation of cAMP-response element-binding protein (CREB), but not NF-kappaB, by aspirin, the abrogation of aspirin-induced expression of CNTF by siRNA knockdown of CREB, the presence of a consensus cAMP-response element in the promoter of CNTF, and the recruitment of CREB and CREB-binding protein to the CNTF promoter by aspirin suggest that aspirin increases the expression of the Cntf gene via the activation of CREB.	Aspirin	113-120	cAMP responsive element binding protein 1	Mus musculus	57-61
23653362-6	2013	The activation of cAMP-response element-binding protein (CREB), but not NF-kappaB, by aspirin, the abrogation of aspirin-induced expression of CNTF by siRNA knockdown of CREB, the presence of a consensus cAMP-response element in the promoter of CNTF, and the recruitment of CREB and CREB-binding protein to the CNTF promoter by aspirin suggest that aspirin increases the expression of the Cntf gene via the activation of CREB.	Aspirin	113-120	cAMP responsive element binding protein 1	Mus musculus	170-174
23653362-6	2013	The activation of cAMP-response element-binding protein (CREB), but not NF-kappaB, by aspirin, the abrogation of aspirin-induced expression of CNTF by siRNA knockdown of CREB, the presence of a consensus cAMP-response element in the promoter of CNTF, and the recruitment of CREB and CREB-binding protein to the CNTF promoter by aspirin suggest that aspirin increases the expression of the Cntf gene via the activation of CREB.	Aspirin	113-120	cAMP responsive element binding protein 1	Mus musculus	18-55
23653362-6	2013	The activation of cAMP-response element-binding protein (CREB), but not NF-kappaB, by aspirin, the abrogation of aspirin-induced expression of CNTF by siRNA knockdown of CREB, the presence of a consensus cAMP-response element in the promoter of CNTF, and the recruitment of CREB and CREB-binding protein to the CNTF promoter by aspirin suggest that aspirin increases the expression of the Cntf gene via the activation of CREB.	Aspirin	113-120	cAMP responsive element binding protein 1	Mus musculus	170-174
23653362-6	2013	The activation of cAMP-response element-binding protein (CREB), but not NF-kappaB, by aspirin, the abrogation of aspirin-induced expression of CNTF by siRNA knockdown of CREB, the presence of a consensus cAMP-response element in the promoter of CNTF, and the recruitment of CREB and CREB-binding protein to the CNTF promoter by aspirin suggest that aspirin increases the expression of the Cntf gene via the activation of CREB.	Aspirin	113-120	cAMP responsive element binding protein 1	Mus musculus	57-61
23653362-6	2013	The activation of cAMP-response element-binding protein (CREB), but not NF-kappaB, by aspirin, the abrogation of aspirin-induced expression of CNTF by siRNA knockdown of CREB, the presence of a consensus cAMP-response element in the promoter of CNTF, and the recruitment of CREB and CREB-binding protein to the CNTF promoter by aspirin suggest that aspirin increases the expression of the Cntf gene via the activation of CREB.	Aspirin	113-120	cAMP responsive element binding protein 1	Mus musculus	170-174
23653362-6	2013	The activation of cAMP-response element-binding protein (CREB), but not NF-kappaB, by aspirin, the abrogation of aspirin-induced expression of CNTF by siRNA knockdown of CREB, the presence of a consensus cAMP-response element in the promoter of CNTF, and the recruitment of CREB and CREB-binding protein to the CNTF promoter by aspirin suggest that aspirin increases the expression of the Cntf gene via the activation of CREB.	Aspirin	113-120	cAMP responsive element binding protein 1	Mus musculus	170-174
23653362-6	2013	The activation of cAMP-response element-binding protein (CREB), but not NF-kappaB, by aspirin, the abrogation of aspirin-induced expression of CNTF by siRNA knockdown of CREB, the presence of a consensus cAMP-response element in the promoter of CNTF, and the recruitment of CREB and CREB-binding protein to the CNTF promoter by aspirin suggest that aspirin increases the expression of the Cntf gene via the activation of CREB.	Aspirin	113-120	cAMP responsive element binding protein 1	Mus musculus	170-174
23653362-6	2013	The activation of cAMP-response element-binding protein (CREB), but not NF-kappaB, by aspirin, the abrogation of aspirin-induced expression of CNTF by siRNA knockdown of CREB, the presence of a consensus cAMP-response element in the promoter of CNTF, and the recruitment of CREB and CREB-binding protein to the CNTF promoter by aspirin suggest that aspirin increases the expression of the Cntf gene via the activation of CREB.	Aspirin	113-120	cAMP responsive element binding protein 1	Mus musculus	18-55
23653362-6	2013	The activation of cAMP-response element-binding protein (CREB), but not NF-kappaB, by aspirin, the abrogation of aspirin-induced expression of CNTF by siRNA knockdown of CREB, the presence of a consensus cAMP-response element in the promoter of CNTF, and the recruitment of CREB and CREB-binding protein to the CNTF promoter by aspirin suggest that aspirin increases the expression of the Cntf gene via the activation of CREB.	Aspirin	113-120	cAMP responsive element binding protein 1	Mus musculus	57-61
23653362-6	2013	The activation of cAMP-response element-binding protein (CREB), but not NF-kappaB, by aspirin, the abrogation of aspirin-induced expression of CNTF by siRNA knockdown of CREB, the presence of a consensus cAMP-response element in the promoter of CNTF, and the recruitment of CREB and CREB-binding protein to the CNTF promoter by aspirin suggest that aspirin increases the expression of the Cntf gene via the activation of CREB.	Aspirin	113-120	cAMP responsive element binding protein 1	Mus musculus	170-174
23653362-6	2013	The activation of cAMP-response element-binding protein (CREB), but not NF-kappaB, by aspirin, the abrogation of aspirin-induced expression of CNTF by siRNA knockdown of CREB, the presence of a consensus cAMP-response element in the promoter of CNTF, and the recruitment of CREB and CREB-binding protein to the CNTF promoter by aspirin suggest that aspirin increases the expression of the Cntf gene via the activation of CREB.	Aspirin	113-120	cAMP responsive element binding protein 1	Mus musculus	170-174
23653362-6	2013	The activation of cAMP-response element-binding protein (CREB), but not NF-kappaB, by aspirin, the abrogation of aspirin-induced expression of CNTF by siRNA knockdown of CREB, the presence of a consensus cAMP-response element in the promoter of CNTF, and the recruitment of CREB and CREB-binding protein to the CNTF promoter by aspirin suggest that aspirin increases the expression of the Cntf gene via the activation of CREB.	Aspirin	113-120	cAMP responsive element binding protein 1	Mus musculus	170-174
23570577-5	2013	Treatment of NSCs with synaptamide at low nanomolar concentrations significantly increased the number of MAP2 and Tuj-1-positive neurons with concomitant induction of protein kinase A (PKA)/cAMP response element binding protein (CREB) phosphorylation.	synaptamide	23-34	cAMP responsive element binding protein 1	Mus musculus	229-233
23473877-0	2013	Oxcarbazepine and fluoxetine protect against mouse models of obsessive compulsive disorder through modulation of cortical serotonin and CREB pathway.	Oxcarbazepine	0-13	cAMP responsive element binding protein 1	Mus musculus	136-140
23473877-0	2013	Oxcarbazepine and fluoxetine protect against mouse models of obsessive compulsive disorder through modulation of cortical serotonin and CREB pathway.	Fluoxetine	18-28	cAMP responsive element binding protein 1	Mus musculus	136-140
23473877-9	2013	8-OHDPAT induced OCD was associated with a concomitant decrease in basal 5-HT levels (88%) and depletion of basal CREB (32%) in the frontal cortex.	8-Hydroxy-2-(di-n-propylamino)tetralin	0-8	cAMP responsive element binding protein 1	Mus musculus	114-118
23473877-10	2013	Chronic treatment with FLX and OXC effectively mitigated the lowering effects of 8-OHDPAT on cortical 5-HT, and enabled an efficient recovery in basal CREB levels.	Fluoxetine	23-26	cAMP responsive element binding protein 1	Mus musculus	151-155
23473877-10	2013	Chronic treatment with FLX and OXC effectively mitigated the lowering effects of 8-OHDPAT on cortical 5-HT, and enabled an efficient recovery in basal CREB levels.	Oxcarbazepine	31-34	cAMP responsive element binding protein 1	Mus musculus	151-155
23458740-2	2013	Cyclic AMP response element binding protein (CREB) is required for swim stress-induced reinstatement of cocaine conditioned place preference.	Cocaine	104-111	cAMP responsive element binding protein 1	Mus musculus	0-43
23458740-2	2013	Cyclic AMP response element binding protein (CREB) is required for swim stress-induced reinstatement of cocaine conditioned place preference.	Cocaine	104-111	cAMP responsive element binding protein 1	Mus musculus	45-49
23458740-6	2013	While CREB is necessary for swim stress-elicited zif268 expression within the nucleus accubmens (NAc) shell and prelimbic cortex (PrL), restraint-stress-elicited comparable increases in zif268 expression within these regions in both wild-type and CREBalphaDelta mutant mice.	nac	97-100	cAMP responsive element binding protein 1	Mus musculus	6-10
23475543-6	2013	Furthermore, activation of cAMP response element binding (CREB) protein, but not NF-kappaB, by NaB, abrogation of NaB-induced expression of neurotrophic factors by siRNA knockdown of CREB and the recruitment of CREB and CREB-binding protein to the BDNF promoter by NaB suggest that NaB exerts its neurotrophic effect through the activation of CREB.	Cyclic AMP	27-31	cAMP responsive element binding protein 1	Mus musculus	58-62
23475543-6	2013	Furthermore, activation of cAMP response element binding (CREB) protein, but not NF-kappaB, by NaB, abrogation of NaB-induced expression of neurotrophic factors by siRNA knockdown of CREB and the recruitment of CREB and CREB-binding protein to the BDNF promoter by NaB suggest that NaB exerts its neurotrophic effect through the activation of CREB.	nab	95-98	cAMP responsive element binding protein 1	Mus musculus	58-62
23475543-6	2013	Furthermore, activation of cAMP response element binding (CREB) protein, but not NF-kappaB, by NaB, abrogation of NaB-induced expression of neurotrophic factors by siRNA knockdown of CREB and the recruitment of CREB and CREB-binding protein to the BDNF promoter by NaB suggest that NaB exerts its neurotrophic effect through the activation of CREB.	nab	114-117	cAMP responsive element binding protein 1	Mus musculus	58-62
23475543-6	2013	Furthermore, activation of cAMP response element binding (CREB) protein, but not NF-kappaB, by NaB, abrogation of NaB-induced expression of neurotrophic factors by siRNA knockdown of CREB and the recruitment of CREB and CREB-binding protein to the BDNF promoter by NaB suggest that NaB exerts its neurotrophic effect through the activation of CREB.	nab	114-117	cAMP responsive element binding protein 1	Mus musculus	183-187
23475543-6	2013	Furthermore, activation of cAMP response element binding (CREB) protein, but not NF-kappaB, by NaB, abrogation of NaB-induced expression of neurotrophic factors by siRNA knockdown of CREB and the recruitment of CREB and CREB-binding protein to the BDNF promoter by NaB suggest that NaB exerts its neurotrophic effect through the activation of CREB.	nab	114-117	cAMP responsive element binding protein 1	Mus musculus	183-187
23475543-8	2013	These results highlight a novel neutrophic property of cinnamon and its metabolite NaB via PKA - CREB pathway, which may be of benefit for various neurodegenerative disorders.	nab	83-86	cAMP responsive element binding protein 1	Mus musculus	97-101
23685142-0	2013	Resveratrol improves learning and memory in normally aged mice through microRNA-CREB pathway.	Resveratrol	0-11	cAMP responsive element binding protein 1	Mus musculus	80-84
23685142-7	2013	Additional experiments suggest that RSV effects are likely to be mediated through reduced expressions of miR-134 and miR-124, which may in turn up-regulate CREB levels to subsequently promote BDNF synthesis.	Resveratrol	36-39	cAMP responsive element binding protein 1	Mus musculus	156-160
23685142-8	2013	These findings demonstrate a role for RSV in cognition and a microRNA-CREB-BDNF mechanism by which RSV regulates these processes, demonstrating its value as a potential therapeutic target against CNS disorders in aging.	Resveratrol	99-102	cAMP responsive element binding protein 1	Mus musculus	70-74
23799052-0	2013	Dopamine receptors modulate cytotoxicity of natural killer cells via cAMP-PKA-CREB signaling pathway.	Cyclic AMP	69-73	cAMP responsive element binding protein 1	Mus musculus	78-82
23799052-8	2013	Simultaneously, SKF38393 elevated D1R and D5R expression, cAMP content, and phosphorylated cAMP-response element-binding (CREB) level in NK cells, while quinpirole reduced D3R and D4R expression, cAMP content, and phosphorylated CREB level in NK cells.	Quinpirole	153-163	cAMP responsive element binding protein 1	Mus musculus	229-233
23799052-8	2013	Simultaneously, SKF38393 elevated D1R and D5R expression, cAMP content, and phosphorylated cAMP-response element-binding (CREB) level in NK cells, while quinpirole reduced D3R and D4R expression, cAMP content, and phosphorylated CREB level in NK cells.	Cyclic AMP	91-95	cAMP responsive element binding protein 1	Mus musculus	122-126
23799052-11	2013	These findings show that DA receptor subtypes are involved in modulation of NK cells and suggest that D1-like receptors facilitate NK cells by stimulating D1R/D5R-cAMP-PKA-CREB signaling pathway and D2-like receptors suppress NK cells by inhibiting D3R/D4R-cAMP-PKA-CREB signaling pathway.	Cyclic AMP	163-167	cAMP responsive element binding protein 1	Mus musculus	172-176
23429041-5	2013	Additionally, DHA decreased luciferase activity of COX-2 regulation-related transcription factors including NF-kappaB, AP-1, C/EBP and CREB.	artenimol	14-17	cAMP responsive element binding protein 1	Mus musculus	135-139
23429041-6	2013	DHA also remarkably reduced PMA-induced p65, C/EBPbeta, c-jun and CREB nuclear translocation.	artenimol	0-3	cAMP responsive element binding protein 1	Mus musculus	66-70
23429041-6	2013	DHA also remarkably reduced PMA-induced p65, C/EBPbeta, c-jun and CREB nuclear translocation.	Tetradecanoylphorbol Acetate	28-31	cAMP responsive element binding protein 1	Mus musculus	66-70
23504989-1	2013	The transcription factor cAMP response element binding protein (CREB) is a key protein implicated in memory, synaptic plasticity and structural plasticity in mammals.	Cyclic AMP	25-29	cAMP responsive element binding protein 1	Mus musculus	64-68
23570577-10	2013	These results suggest that endogenously produced synaptamide is a potent mediator for neurogenic differentiation of NSCs acting through PKA/CREB activation.	synaptamide	49-60	cAMP responsive element binding protein 1	Mus musculus	140-144
22695008-1	2013	Calcium-calmodulin dependent protein kinase IV (CaMKIV) is a protein kinase that has been suggested to participate in fluoxetine (FLX)-induced phosphorylation of cyclic AMP-response element binding protein (CREB).	Fluoxetine	118-128	cAMP responsive element binding protein 1	Mus musculus	162-205
22180388-5	2013	Moreover, deoxyactein increased the activation of PI3K (phosphoinositide 3-kinase), Akt (protein kinase B) and CREB (cAMP-response element-binding protein) inhibited by antimycin A.	Antimycin A	169-180	cAMP responsive element binding protein 1	Mus musculus	111-115
22180388-5	2013	Moreover, deoxyactein increased the activation of PI3K (phosphoinositide 3-kinase), Akt (protein kinase B) and CREB (cAMP-response element-binding protein) inhibited by antimycin A.	Antimycin A	169-180	cAMP responsive element binding protein 1	Mus musculus	117-154
23803537-9	2013	CONCLUSION: In the enriched environment, the learning and memory ability of manganese-exposed mice can be improved, which may be due to the increased expression of CREB in the hippocampus.	Manganese	76-85	cAMP responsive element binding protein 1	Mus musculus	164-168
23480967-2	2013	We used radioimmunoassays and quantitative PCR to evaluate the function and expression of the Leydig cell genes involved in the conversion of cholesterol to testosterone (Star, Cyp11a1, Hsd3b6, Cyp17a1 and Hsd17b3), androgen metabolism (Srda1 and Dhrs9), and four transcription factors (Creb1, Nr5a1, Nr4a1 and Nr0b1) that regulate the expression of steroidogenic genes.	Cholesterol	142-153	cAMP responsive element binding protein 1	Mus musculus	287-292
22695008-1	2013	Calcium-calmodulin dependent protein kinase IV (CaMKIV) is a protein kinase that has been suggested to participate in fluoxetine (FLX)-induced phosphorylation of cyclic AMP-response element binding protein (CREB).	Fluoxetine	118-128	cAMP responsive element binding protein 1	Mus musculus	207-211
22695008-1	2013	Calcium-calmodulin dependent protein kinase IV (CaMKIV) is a protein kinase that has been suggested to participate in fluoxetine (FLX)-induced phosphorylation of cyclic AMP-response element binding protein (CREB).	Fluoxetine	130-133	cAMP responsive element binding protein 1	Mus musculus	162-205
22695008-1	2013	Calcium-calmodulin dependent protein kinase IV (CaMKIV) is a protein kinase that has been suggested to participate in fluoxetine (FLX)-induced phosphorylation of cyclic AMP-response element binding protein (CREB).	Fluoxetine	130-133	cAMP responsive element binding protein 1	Mus musculus	207-211
22695008-9	2013	Phosphorylation of CaMKIV was up-regulated in WT mice and phosphorylation of CREB was impaired in CaMKIV KO mice after FLX treatment.	Fluoxetine	119-122	cAMP responsive element binding protein 1	Mus musculus	77-81
23805515-8	2013	CONCLUSIONS: The abnormal changes of expression of the signal molecules composing the cAMP/PKA-CREB signaling pathway were observed in the hippocampus of DiBP exposure mice.	Cyclic AMP	86-90	cAMP responsive element binding protein 1	Mus musculus	95-99
23324999-4	2013	Among these are, the cAMP response element binding (CREB) protein, extracellular signal-regulated kinase (ERK), both CREB and ERK-part of the mitogen-activated kinase pathway-were upregulated by lithium, downregulated by MPTP, and maintained in mice fed with lithium chloride (LiCl) supplemented diet and treated with MPTP.	Lithium Chloride	259-275	cAMP responsive element binding protein 1	Mus musculus	21-50
23637738-7	2013	In vitro studies using mouse MLE-15 epithelial cells showed that forskolin-mediated activation of Creb1 increased both Scd1 gene expression and protein synthesis.	Colforsin	65-74	cAMP responsive element binding protein 1	Mus musculus	98-103
23805515-0	2013	[Effects of DiBP on the cAMP/PKA-CREB-BDNF signaling pathway of hippocampus in mice].	diisobutyl phthalate	12-16	cAMP responsive element binding protein 1	Mus musculus	33-37
23805515-0	2013	[Effects of DiBP on the cAMP/PKA-CREB-BDNF signaling pathway of hippocampus in mice].	Cyclic AMP	24-28	cAMP responsive element binding protein 1	Mus musculus	33-37
23805515-1	2013	OBJECTIVE: To explore the effects of diisobutyl phthalate (DiBP) on the cAMP/PKA-CREB signaling pathway of hippocampus in mice.	diisobutyl phthalate	37-57	cAMP responsive element binding protein 1	Mus musculus	81-85
23805515-1	2013	OBJECTIVE: To explore the effects of diisobutyl phthalate (DiBP) on the cAMP/PKA-CREB signaling pathway of hippocampus in mice.	diisobutyl phthalate	59-63	cAMP responsive element binding protein 1	Mus musculus	81-85
23805515-1	2013	OBJECTIVE: To explore the effects of diisobutyl phthalate (DiBP) on the cAMP/PKA-CREB signaling pathway of hippocampus in mice.	Cyclic AMP	72-76	cAMP responsive element binding protein 1	Mus musculus	81-85
23805515-7	2013	RESULTS: The cAMP content and the p-PKA C protein of hippocampus in IV group was significantly less than control group (P&lt;0.05) and compared with control group, the p-CREB protein of hippocampus in 1I group decreased (P&lt;0.05), while the relative level of CREB, BDNF, c-fos and c-jun mRNA were down-regulated in all experimental groups.	Cyclic AMP	13-17	cAMP responsive element binding protein 1	Mus musculus	170-174
23370322-7	2013	The levels of acetylcholine (ACH) and choline acetyltransferase (ChAT), the degree of histone acetylation and the cAMP response element-binding protein (CREB) phosphorylation in the central cholinergic circuits were investigated by Western blot and immunofluorescence.	Cyclic AMP	114-118	cAMP responsive element binding protein 1	Mus musculus	153-157
23370322-10	2013	In conclusion, ICA can improve post-stroke dementia, and the mechanism is likely to enhance CREB phosphorylation in the central cholinergic circuits, thus improving the damage in cholinergic circuits histone acetylation homeostasis.	icariin	15-18	cAMP responsive element binding protein 1	Mus musculus	92-96
23324999-4	2013	Among these are, the cAMP response element binding (CREB) protein, extracellular signal-regulated kinase (ERK), both CREB and ERK-part of the mitogen-activated kinase pathway-were upregulated by lithium, downregulated by MPTP, and maintained in mice fed with lithium chloride (LiCl) supplemented diet and treated with MPTP.	Lithium	195-202	cAMP responsive element binding protein 1	Mus musculus	21-50
23324999-4	2013	Among these are, the cAMP response element binding (CREB) protein, extracellular signal-regulated kinase (ERK), both CREB and ERK-part of the mitogen-activated kinase pathway-were upregulated by lithium, downregulated by MPTP, and maintained in mice fed with lithium chloride (LiCl) supplemented diet and treated with MPTP.	Lithium	195-202	cAMP responsive element binding protein 1	Mus musculus	52-56
23324999-4	2013	Among these are, the cAMP response element binding (CREB) protein, extracellular signal-regulated kinase (ERK), both CREB and ERK-part of the mitogen-activated kinase pathway-were upregulated by lithium, downregulated by MPTP, and maintained in mice fed with lithium chloride (LiCl) supplemented diet and treated with MPTP.	Lithium	195-202	cAMP responsive element binding protein 1	Mus musculus	117-121
23324999-4	2013	Among these are, the cAMP response element binding (CREB) protein, extracellular signal-regulated kinase (ERK), both CREB and ERK-part of the mitogen-activated kinase pathway-were upregulated by lithium, downregulated by MPTP, and maintained in mice fed with lithium chloride (LiCl) supplemented diet and treated with MPTP.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	221-225	cAMP responsive element binding protein 1	Mus musculus	21-50
23324999-4	2013	Among these are, the cAMP response element binding (CREB) protein, extracellular signal-regulated kinase (ERK), both CREB and ERK-part of the mitogen-activated kinase pathway-were upregulated by lithium, downregulated by MPTP, and maintained in mice fed with lithium chloride (LiCl) supplemented diet and treated with MPTP.	Lithium Chloride	277-281	cAMP responsive element binding protein 1	Mus musculus	21-50
23324999-4	2013	Among these are, the cAMP response element binding (CREB) protein, extracellular signal-regulated kinase (ERK), both CREB and ERK-part of the mitogen-activated kinase pathway-were upregulated by lithium, downregulated by MPTP, and maintained in mice fed with lithium chloride (LiCl) supplemented diet and treated with MPTP.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	318-322	cAMP responsive element binding protein 1	Mus musculus	21-50
23159329-0	2013	Distinct roles of methamphetamine in modulating spatial memory consolidation, retrieval, reconsolidation and the accompanying changes of ERK and CREB activation in hippocampus and prefrontal cortex.	Methamphetamine	18-33	cAMP responsive element binding protein 1	Mus musculus	145-149
23493374-10	2013	Separate 5-aza-2"-deoxycytidine pretreatment or in combination with trichostatin A reduced (m)CpG and specific small interference RNAs targeting Mecp2 and Creb1 separately or together depleting Mecp2 and/or Creb1 binding of glut3-(m)CpGs reduced glut3 expression in HT22 cells.	Decitabine	9-31	cAMP responsive element binding protein 1	Mus musculus	207-212
23318871-4	2013	Phosphorylation of cAMP response element-binding protein (CREB) is also significantly increased in hypocretin neurons in cocaine-treated animals, suggesting that CREB-mediated pathways may contribute to synaptic potentiation in these cells.	Cocaine	121-128	cAMP responsive element binding protein 1	Mus musculus	19-56
23318871-4	2013	Phosphorylation of cAMP response element-binding protein (CREB) is also significantly increased in hypocretin neurons in cocaine-treated animals, suggesting that CREB-mediated pathways may contribute to synaptic potentiation in these cells.	Cocaine	121-128	cAMP responsive element binding protein 1	Mus musculus	58-62
23318871-4	2013	Phosphorylation of cAMP response element-binding protein (CREB) is also significantly increased in hypocretin neurons in cocaine-treated animals, suggesting that CREB-mediated pathways may contribute to synaptic potentiation in these cells.	Cocaine	121-128	cAMP responsive element binding protein 1	Mus musculus	162-166
23231807-10	2013	Our results demonstrate that quercetin treatment for Abeta(25-35)-induced amnesic mice improved the learning and memory capabilities and conferred robust neurovascular coupling protection, involving maintenance of the NVU integrity, reduction of neurovascular oxidation, modulation of microvascular function, improvement of cholinergic system, and regulation of neurovascular RAGE signaling pathway and ERK/CREB/BDNF pathway.	Quercetin	29-38	cAMP responsive element binding protein 1	Mus musculus	407-411
23159329-9	2013	In contrast, activation of both ERK and CREB in the PFC was found following memory retrieval but not other processes in METH-treated mouse groups.	Methamphetamine	120-124	cAMP responsive element binding protein 1	Mus musculus	40-44
23159329-11	2013	Moreover, activation of the ERK and CREB signaling pathway in the hippocampus might be involved in METH-induced spatial memory changes.	Methamphetamine	99-103	cAMP responsive element binding protein 1	Mus musculus	36-40
23313392-13	2013	CONCLUSIONS: Ginsenoside Rg5 and its metabolite ginsenoside Rh3 may protect memory deficit by inhibiting AChE activity and increasing BDNF expression and CREB activation.	ginsenoside Rh3	48-63	cAMP responsive element binding protein 1	Mus musculus	154-158
23360889-7	2013	Interestingly, we found that surfactin increased the level of cAMP and induced phosphorylation of cAMP responsive element binding protein (CREB) in microglial cells.	surfactin peptide	29-38	cAMP responsive element binding protein 1	Mus musculus	98-137
23360889-7	2013	Interestingly, we found that surfactin increased the level of cAMP and induced phosphorylation of cAMP responsive element binding protein (CREB) in microglial cells.	surfactin peptide	29-38	cAMP responsive element binding protein 1	Mus musculus	139-143
23313392-11	2013	These ginsenosides also reversed hippocampal brain-derived neurotrophic factor (BDNF) expression and cAMP response element-binding protein (CREB) phosphorylation reduced by scopolamine.	Ginsenosides	6-18	cAMP responsive element binding protein 1	Mus musculus	101-138
23313392-11	2013	These ginsenosides also reversed hippocampal brain-derived neurotrophic factor (BDNF) expression and cAMP response element-binding protein (CREB) phosphorylation reduced by scopolamine.	Ginsenosides	6-18	cAMP responsive element binding protein 1	Mus musculus	140-144
23467349-7	2013	Our results indicate that A2AR-mediated CREB signaling in the DMS is a key determinant in enhancing the development of goal-directed ethanol drinking in mice.	Ethanol	133-140	cAMP responsive element binding protein 1	Mus musculus	40-44
23313392-11	2013	These ginsenosides also reversed hippocampal brain-derived neurotrophic factor (BDNF) expression and cAMP response element-binding protein (CREB) phosphorylation reduced by scopolamine.	Scopolamine	173-184	cAMP responsive element binding protein 1	Mus musculus	101-138
23313392-11	2013	These ginsenosides also reversed hippocampal brain-derived neurotrophic factor (BDNF) expression and cAMP response element-binding protein (CREB) phosphorylation reduced by scopolamine.	Scopolamine	173-184	cAMP responsive element binding protein 1	Mus musculus	140-144
23313392-13	2013	CONCLUSIONS: Ginsenoside Rg5 and its metabolite ginsenoside Rh3 may protect memory deficit by inhibiting AChE activity and increasing BDNF expression and CREB activation.	Ginsenosides	13-24	cAMP responsive element binding protein 1	Mus musculus	154-158
23467349-4	2013	In the present study, we found that decreased A2AR-mediated CREB activity in the dorsomedial striatum (DMS) enhanced initial behavioral acquisition of goal-directed behaviors and the vulnerability to progress to excessive ethanol drinking during operant conditioning in mice lacking ethanol-sensitive adenosine transporter ENT1 (ENT1(-/-)).	Ethanol	222-229	cAMP responsive element binding protein 1	Mus musculus	60-64
23220172-7	2013	To verify whether the observed stimulating effects on mitochondrial biogenesis pathways are caused by selenoprotein H and mediated through CREB, we knocked down selenoprotein H mRNA level using siRNA and inhibited CREB with napthol AS-E phosphate in selenoprotein H transfected cells and repeated the measurements of the aforementioned biomarkers.	napthol	224-231	cAMP responsive element binding protein 1	Mus musculus	214-218
23467349-4	2013	In the present study, we found that decreased A2AR-mediated CREB activity in the dorsomedial striatum (DMS) enhanced initial behavioral acquisition of goal-directed behaviors and the vulnerability to progress to excessive ethanol drinking during operant conditioning in mice lacking ethanol-sensitive adenosine transporter ENT1 (ENT1(-/-)).	Ethanol	283-290	cAMP responsive element binding protein 1	Mus musculus	60-64
23174209-5	2013	Finally, sildenafil restored central cAMP responsive element-binding protein (CREB) phosphorylation, which is crucial for synaptic plasticity and memory.	Sildenafil Citrate	9-19	cAMP responsive element binding protein 1	Mus musculus	37-76
23174209-5	2013	Finally, sildenafil restored central cAMP responsive element-binding protein (CREB) phosphorylation, which is crucial for synaptic plasticity and memory.	Sildenafil Citrate	9-19	cAMP responsive element binding protein 1	Mus musculus	78-82
22508336-12	2013	As increases in striatal BDNF and CREB activity are well implicated in depressive behaviour and reward, we suggest these signalling molecules may mediate the effects of high-fat feeding and DIO to promote negative emotional states and depressive-like symptomology.	3,3'-Dioctadecyloxacarbocyanine perchlorate	190-193	cAMP responsive element binding protein 1	Mus musculus	34-38
23365234-8	2013	These findings suggest that post-training intra-CA1 TSA infusion promotes dynamic shift from striatum toward the hippocampal system in young but not aged animals, and support the possibility of a role for CREB in the TSA-mediated switch between these two memory systems.	trichostatin A	52-55	cAMP responsive element binding protein 1	Mus musculus	205-209
23085336-2	2013	A transcription factor fundamental for several plasticity mechanisms in various CNS areas is the cAMP response element-binding protein, CREB.	Cyclic AMP	97-101	cAMP responsive element binding protein 1	Mus musculus	136-140
23085336-5	2013	In the present work we studied by Western blot analysis the modulation of CREB expression and activation in the mouse superior colliculus in three models of neuronal plasticity: (1) developmental plasticity; (2) lesion-induced plasticity; (3) and fluoxetine-induced restored plasticity.	Fluoxetine	247-257	cAMP responsive element binding protein 1	Mus musculus	74-78
23085336-7	2013	The results showed that: (1) the expression and activation of CREB increase during the development of the superior colliculus in temporal correlation with the plastic process of refinement of retino-collicular projections; (2) the activation of CREB is induced by a monocular lesion performed during the critical period for plasticity in young animals but not when performed in less plastic juvenile mice; (3) the expression and activation of CREB increase in adult animals treated with fluoxetine, known to restore high levels of plasticity in adult animals.	Fluoxetine	487-497	cAMP responsive element binding protein 1	Mus musculus	62-66
23085336-7	2013	The results showed that: (1) the expression and activation of CREB increase during the development of the superior colliculus in temporal correlation with the plastic process of refinement of retino-collicular projections; (2) the activation of CREB is induced by a monocular lesion performed during the critical period for plasticity in young animals but not when performed in less plastic juvenile mice; (3) the expression and activation of CREB increase in adult animals treated with fluoxetine, known to restore high levels of plasticity in adult animals.	Fluoxetine	487-497	cAMP responsive element binding protein 1	Mus musculus	245-249
23085336-7	2013	The results showed that: (1) the expression and activation of CREB increase during the development of the superior colliculus in temporal correlation with the plastic process of refinement of retino-collicular projections; (2) the activation of CREB is induced by a monocular lesion performed during the critical period for plasticity in young animals but not when performed in less plastic juvenile mice; (3) the expression and activation of CREB increase in adult animals treated with fluoxetine, known to restore high levels of plasticity in adult animals.	Fluoxetine	487-497	cAMP responsive element binding protein 1	Mus musculus	245-249
23011268-8	2013	Bupropion induced the greatest effect on CREB in DISC1-Q31L mutants, whereas all studied ADs corrected the reduced levels of beta-arrestin-1,2 and modestly ameliorated deficient spine density in this brain region.	Bupropion	0-9	cAMP responsive element binding protein 1	Mus musculus	41-45
23182882-0	2013	Transcriptional regulation of mouse neuroglobin gene by cyclic AMP responsive element binding protein (CREB) in N2a cells.	Cyclic AMP	56-66	cAMP responsive element binding protein 1	Mus musculus	103-107
23182882-6	2013	Moreover, a cAMP response element (CRE) site located at -854 in the promoter region of mouse Ngb gene was found to be responsible for both basal and CREB-induced Ngb promoter activity.	Cyclic AMP	12-16	cAMP responsive element binding protein 1	Mus musculus	149-153
22226089-0	2013	The antidepressant hyperforin increases the phosphorylation of CREB and the expression of TrkB in a tissue-specific manner.	hyperforin	19-29	cAMP responsive element binding protein 1	Mus musculus	63-67
22226089-8	2013	Hyperforin stimulated the expression of TRPC6 channels and TrkB via SKF-96365-sensitive channels controlling a downstream signalling cascade involving Ca(2+), protein kinase A, CREB and p-CREB.	hyperforin	0-10	cAMP responsive element binding protein 1	Mus musculus	177-181
22226089-8	2013	Hyperforin stimulated the expression of TRPC6 channels and TrkB via SKF-96365-sensitive channels controlling a downstream signalling cascade involving Ca(2+), protein kinase A, CREB and p-CREB.	hyperforin	0-10	cAMP responsive element binding protein 1	Mus musculus	188-192
22980225-5	2013	RESULTS: In this study, we showed ATF4 to be a negative regulator of PGC1alpha expression through competitive binding with cAMP response element binding protein (CREB) at a cAMP response element (CRE) site in the PGC1alpha promoter.	Cyclic AMP	123-127	cAMP responsive element binding protein 1	Mus musculus	162-166
23340021-11	2013	These results suggest that BK-mediated reduction in microglial NO production depends on coupling to Gi protein and also involves inhibition of cAMP-PKA-CREB signaling.	Cyclic AMP	143-147	cAMP responsive element binding protein 1	Mus musculus	152-156
23292329-8	2013	For the protein expression, there was a significant increment of cAMP and CREB levels (p &lt; 0.05) in group treated with  5 mg/kg morphine but there was no significant change of these protein expressions when MG was combined with morphine.	Morphine	131-139	cAMP responsive element binding protein 1	Mus musculus	74-78
23018126-4	2013	OB caused significant increases in ERK1 and CREB (Ser(133)) phosphorylation and in the expression of BDNF immunocontent, all of which were prevented by fluoxetine administration.	Fluoxetine	152-162	cAMP responsive element binding protein 1	Mus musculus	44-48
23018126-8	2013	Conversely, fluoxetine prevented these OB-induced behavioral changes and avoided the activation of ERK1/CREB/BDNF in the hippocampus.	Fluoxetine	12-22	cAMP responsive element binding protein 1	Mus musculus	104-108
23665701-1	2013	Our previous study reported that thyroid-stimulating hormone (TSH) promotes cholesterol synthesis via the cyclic adenosine monophosphate/protein kinase A/cAMP regulatory element-binding protein (cAMP/PKA/CREB) pathway after binding to TSH receptors (TSHR) in the liver.	Cholesterol	76-87	cAMP responsive element binding protein 1	Mus musculus	204-208
23248313-5	2013	Therefore, the signal transduction of a chimeric trace-amine-associated receptor 1 (cTAAR1) was functionally rewired via cAMP and cAMP-dependent phosphokinase A (PKA)-mediated activation of the cAMP-response element binding protein (CREB1) to transcription of synthetic promoters containing CREB1-specific cAMP response elements.	Cyclic AMP	130-134	cAMP responsive element binding protein 1	Mus musculus	233-238
23248313-5	2013	Therefore, the signal transduction of a chimeric trace-amine-associated receptor 1 (cTAAR1) was functionally rewired via cAMP and cAMP-dependent phosphokinase A (PKA)-mediated activation of the cAMP-response element binding protein (CREB1) to transcription of synthetic promoters containing CREB1-specific cAMP response elements.	Cyclic AMP	121-125	cAMP responsive element binding protein 1	Mus musculus	233-238
23248313-5	2013	Therefore, the signal transduction of a chimeric trace-amine-associated receptor 1 (cTAAR1) was functionally rewired via cAMP and cAMP-dependent phosphokinase A (PKA)-mediated activation of the cAMP-response element binding protein (CREB1) to transcription of synthetic promoters containing CREB1-specific cAMP response elements.	Cyclic AMP	121-125	cAMP responsive element binding protein 1	Mus musculus	291-296
23248313-5	2013	Therefore, the signal transduction of a chimeric trace-amine-associated receptor 1 (cTAAR1) was functionally rewired via cAMP and cAMP-dependent phosphokinase A (PKA)-mediated activation of the cAMP-response element binding protein (CREB1) to transcription of synthetic promoters containing CREB1-specific cAMP response elements.	Cyclic AMP	130-134	cAMP responsive element binding protein 1	Mus musculus	233-238
23248313-5	2013	Therefore, the signal transduction of a chimeric trace-amine-associated receptor 1 (cTAAR1) was functionally rewired via cAMP and cAMP-dependent phosphokinase A (PKA)-mediated activation of the cAMP-response element binding protein (CREB1) to transcription of synthetic promoters containing CREB1-specific cAMP response elements.	Cyclic AMP	130-134	cAMP responsive element binding protein 1	Mus musculus	291-296
23248313-5	2013	Therefore, the signal transduction of a chimeric trace-amine-associated receptor 1 (cTAAR1) was functionally rewired via cAMP and cAMP-dependent phosphokinase A (PKA)-mediated activation of the cAMP-response element binding protein (CREB1) to transcription of synthetic promoters containing CREB1-specific cAMP response elements.	Cyclic AMP	130-134	cAMP responsive element binding protein 1	Mus musculus	291-296
23248313-5	2013	Therefore, the signal transduction of a chimeric trace-amine-associated receptor 1 (cTAAR1) was functionally rewired via cAMP and cAMP-dependent phosphokinase A (PKA)-mediated activation of the cAMP-response element binding protein (CREB1) to transcription of synthetic promoters containing CREB1-specific cAMP response elements.	Cyclic AMP	130-134	cAMP responsive element binding protein 1	Mus musculus	233-238
23248313-5	2013	Therefore, the signal transduction of a chimeric trace-amine-associated receptor 1 (cTAAR1) was functionally rewired via cAMP and cAMP-dependent phosphokinase A (PKA)-mediated activation of the cAMP-response element binding protein (CREB1) to transcription of synthetic promoters containing CREB1-specific cAMP response elements.	Cyclic AMP	130-134	cAMP responsive element binding protein 1	Mus musculus	291-296
23665701-1	2013	Our previous study reported that thyroid-stimulating hormone (TSH) promotes cholesterol synthesis via the cyclic adenosine monophosphate/protein kinase A/cAMP regulatory element-binding protein (cAMP/PKA/CREB) pathway after binding to TSH receptors (TSHR) in the liver.	Cyclic AMP	154-158	cAMP responsive element binding protein 1	Mus musculus	204-208
23665701-1	2013	Our previous study reported that thyroid-stimulating hormone (TSH) promotes cholesterol synthesis via the cyclic adenosine monophosphate/protein kinase A/cAMP regulatory element-binding protein (cAMP/PKA/CREB) pathway after binding to TSH receptors (TSHR) in the liver.	Cyclic AMP	195-199	cAMP responsive element binding protein 1	Mus musculus	204-208
23665701-2	2013	The hepatic cAMP/PKA/CREB pathway also plays an important role in maintaining fasting glucose homeostasis.	Cyclic AMP	12-16	cAMP responsive element binding protein 1	Mus musculus	21-25
23064259-0	2013	beta-Asarone inhibits neuronal apoptosis via the CaMKII/CREB/Bcl-2 signaling pathway in an in vitro model and AbetaPP/PS1 mice.	asarone	0-12	cAMP responsive element binding protein 1	Mus musculus	56-60
23064259-9	2013	A significant increase in CaMKII/CREB/Bcl-2 expression was observed in the cortex of the AbetaPP/PS1 mice treated with beta-asarone.	asarone	119-131	cAMP responsive element binding protein 1	Mus musculus	33-37
23064259-10	2013	In summary, our observations demonstrated that beta-asarone can inhibit neuronal apoptosis via the CaMKII/CREB/Bcl-2 signaling pathway in in vitro models and in AbetaPP/PS1 mice.	asarone	47-59	cAMP responsive element binding protein 1	Mus musculus	106-110
22980861-3	2012	The levels of oxidative stress, the amount of Na(+),K(+)-ATPase and extracellular signal-regulated kinases (ERK)-cyclic AMP response element binding protein (CREB) signaling pathway in hippocampus were also analysed.	Cyclic AMP	113-123	cAMP responsive element binding protein 1	Mus musculus	158-162
22771768-3	2013	Given their ability to prevent hydrolysis of cAMP and/or cGMP, they can stimulate the cAMP/protein kinase A (PKA)/cAMP element-binding protein (CREB) and cGMP/PKG/CREB pathway to enhance synaptic transmission by increasing CREB phosphorylation (pCREB) and brain-derived neurotrophic factor (BDNF) transcription.	Cyclic AMP	45-49	cAMP responsive element binding protein 1	Mus musculus	144-148
22771768-3	2013	Given their ability to prevent hydrolysis of cAMP and/or cGMP, they can stimulate the cAMP/protein kinase A (PKA)/cAMP element-binding protein (CREB) and cGMP/PKG/CREB pathway to enhance synaptic transmission by increasing CREB phosphorylation (pCREB) and brain-derived neurotrophic factor (BDNF) transcription.	Cyclic AMP	45-49	cAMP responsive element binding protein 1	Mus musculus	163-167
22771768-3	2013	Given their ability to prevent hydrolysis of cAMP and/or cGMP, they can stimulate the cAMP/protein kinase A (PKA)/cAMP element-binding protein (CREB) and cGMP/PKG/CREB pathway to enhance synaptic transmission by increasing CREB phosphorylation (pCREB) and brain-derived neurotrophic factor (BDNF) transcription.	Cyclic AMP	45-49	cAMP responsive element binding protein 1	Mus musculus	163-167
22771768-3	2013	Given their ability to prevent hydrolysis of cAMP and/or cGMP, they can stimulate the cAMP/protein kinase A (PKA)/cAMP element-binding protein (CREB) and cGMP/PKG/CREB pathway to enhance synaptic transmission by increasing CREB phosphorylation (pCREB) and brain-derived neurotrophic factor (BDNF) transcription.	Cyclic GMP	57-61	cAMP responsive element binding protein 1	Mus musculus	144-148
22771768-3	2013	Given their ability to prevent hydrolysis of cAMP and/or cGMP, they can stimulate the cAMP/protein kinase A (PKA)/cAMP element-binding protein (CREB) and cGMP/PKG/CREB pathway to enhance synaptic transmission by increasing CREB phosphorylation (pCREB) and brain-derived neurotrophic factor (BDNF) transcription.	Cyclic GMP	57-61	cAMP responsive element binding protein 1	Mus musculus	163-167
22771768-3	2013	Given their ability to prevent hydrolysis of cAMP and/or cGMP, they can stimulate the cAMP/protein kinase A (PKA)/cAMP element-binding protein (CREB) and cGMP/PKG/CREB pathway to enhance synaptic transmission by increasing CREB phosphorylation (pCREB) and brain-derived neurotrophic factor (BDNF) transcription.	Cyclic GMP	57-61	cAMP responsive element binding protein 1	Mus musculus	163-167
22771768-3	2013	Given their ability to prevent hydrolysis of cAMP and/or cGMP, they can stimulate the cAMP/protein kinase A (PKA)/cAMP element-binding protein (CREB) and cGMP/PKG/CREB pathway to enhance synaptic transmission by increasing CREB phosphorylation (pCREB) and brain-derived neurotrophic factor (BDNF) transcription.	Cyclic AMP	86-90	cAMP responsive element binding protein 1	Mus musculus	144-148
22771768-3	2013	Given their ability to prevent hydrolysis of cAMP and/or cGMP, they can stimulate the cAMP/protein kinase A (PKA)/cAMP element-binding protein (CREB) and cGMP/PKG/CREB pathway to enhance synaptic transmission by increasing CREB phosphorylation (pCREB) and brain-derived neurotrophic factor (BDNF) transcription.	Cyclic AMP	86-90	cAMP responsive element binding protein 1	Mus musculus	144-148
22771768-3	2013	Given their ability to prevent hydrolysis of cAMP and/or cGMP, they can stimulate the cAMP/protein kinase A (PKA)/cAMP element-binding protein (CREB) and cGMP/PKG/CREB pathway to enhance synaptic transmission by increasing CREB phosphorylation (pCREB) and brain-derived neurotrophic factor (BDNF) transcription.	Cyclic GMP	154-158	cAMP responsive element binding protein 1	Mus musculus	163-167
22771768-3	2013	Given their ability to prevent hydrolysis of cAMP and/or cGMP, they can stimulate the cAMP/protein kinase A (PKA)/cAMP element-binding protein (CREB) and cGMP/PKG/CREB pathway to enhance synaptic transmission by increasing CREB phosphorylation (pCREB) and brain-derived neurotrophic factor (BDNF) transcription.	Cyclic GMP	154-158	cAMP responsive element binding protein 1	Mus musculus	163-167
23577138-10	2013	Moreover, forskolin, a PKA activator, could facilitate the phosphorylation of CREB, which in turn heightens ORMDL3 expression.	Colforsin	10-19	cAMP responsive element binding protein 1	Mus musculus	78-82
24073333-0	2013	Alterations in phosphorylated CREB expression in different brain regions following short- and long-term morphine exposure: relationship to food intake.	Morphine	104-112	cAMP responsive element binding protein 1	Mus musculus	30-34
24073333-1	2013	BACKGROUND: Activation of the cyclic adenosine monophosphate (cAMP)/phosphorylated CREB (P-CREB) system in different brain regions has been implicated in mediating opioid tolerance and dependence, while alteration of this system in the lateral hypothalamus (LH) has been suggested to have a role in food intake and body weight.	Cyclic AMP	30-60	cAMP responsive element binding protein 1	Mus musculus	83-87
24073333-1	2013	BACKGROUND: Activation of the cyclic adenosine monophosphate (cAMP)/phosphorylated CREB (P-CREB) system in different brain regions has been implicated in mediating opioid tolerance and dependence, while alteration of this system in the lateral hypothalamus (LH) has been suggested to have a role in food intake and body weight.	Cyclic AMP	30-60	cAMP responsive element binding protein 1	Mus musculus	91-95
24073333-1	2013	BACKGROUND: Activation of the cyclic adenosine monophosphate (cAMP)/phosphorylated CREB (P-CREB) system in different brain regions has been implicated in mediating opioid tolerance and dependence, while alteration of this system in the lateral hypothalamus (LH) has been suggested to have a role in food intake and body weight.	Cyclic AMP	62-66	cAMP responsive element binding protein 1	Mus musculus	83-87
24073333-1	2013	BACKGROUND: Activation of the cyclic adenosine monophosphate (cAMP)/phosphorylated CREB (P-CREB) system in different brain regions has been implicated in mediating opioid tolerance and dependence, while alteration of this system in the lateral hypothalamus (LH) has been suggested to have a role in food intake and body weight.	Cyclic AMP	62-66	cAMP responsive element binding protein 1	Mus musculus	91-95
24073333-4	2013	Chronic morphine pellet implantation for 7 days raised P-CREB levels in the LH, VTA, and dorsomedial nucleus of the hypothalamus (DM) but not in the nucleus accumbens and amygdala.	Morphine	8-16	cAMP responsive element binding protein 1	Mus musculus	57-61
24073333-5	2013	Increased P-CREB levels in LH, VTA, and DM following 7-day treatment with morphine pellets and increased P-CREB levels in the VTA following escalating doses of morphine were associated with decreased food intake and body weight.	Morphine	74-82	cAMP responsive element binding protein 1	Mus musculus	12-16
24073333-5	2013	Increased P-CREB levels in LH, VTA, and DM following 7-day treatment with morphine pellets and increased P-CREB levels in the VTA following escalating doses of morphine were associated with decreased food intake and body weight.	Morphine	160-168	cAMP responsive element binding protein 1	Mus musculus	107-111
24073333-6	2013	CONCLUSION: The morphine regulation of P-CREB may explain some of the physiological sequelae of opioid exposure including altered food intake and body weight.	Morphine	16-24	cAMP responsive element binding protein 1	Mus musculus	41-45
22771460-4	2013	Using a CREB reporter gene cell line, we screened a library of small molecules structurally related to known HDAC inhibitors leading to the identification of a probe we termed crebinostat that produced robust activation of CREB-mediated transcription.	(7-(2-((1,1'-biphenyl)-4-ylmethylene)hydrazinyl)-N-hydroxy-7-oxoheptanamide)	176-187	cAMP responsive element binding protein 1	Mus musculus	8-12
22771460-4	2013	Using a CREB reporter gene cell line, we screened a library of small molecules structurally related to known HDAC inhibitors leading to the identification of a probe we termed crebinostat that produced robust activation of CREB-mediated transcription.	(7-(2-((1,1'-biphenyl)-4-ylmethylene)hydrazinyl)-N-hydroxy-7-oxoheptanamide)	176-187	cAMP responsive element binding protein 1	Mus musculus	223-227
22771460-6	2013	In cultured mouse primary neurons, crebinostat potently induced acetylation of both histone H3 and histone H4 as well as enhanced the expression of the CREB target gene Egr1 (early growth response 1).	(7-(2-((1,1'-biphenyl)-4-ylmethylene)hydrazinyl)-N-hydroxy-7-oxoheptanamide)	35-46	cAMP responsive element binding protein 1	Mus musculus	152-156
23565152-10	2013	Neuro2A neuroblastoma cells treated with ASCs-E showed increased expression of p-CREB and PGC1alpha.	ascs-e	41-47	cAMP responsive element binding protein 1	Mus musculus	81-85
22980861-4	2012	It was found that all the three dietary flavonols could ameliorate the oxidative stress, enhance the activity of Na(+),K(+)-ATPase and regulate the expression of ERK-CREB pathway in mice.	Flavonols	40-49	cAMP responsive element binding protein 1	Mus musculus	166-170
22936458-15	2012	The additive effects are associated with an increase in myocardial cAMP levels and PKA activity with downstream phosphorylation of Akt, eNOS, 5-lipoxygenase and CREB and downregulation of PTEN expression.	Cyclic AMP	67-71	cAMP responsive element binding protein 1	Mus musculus	161-165
23105098-11	2012	Our findings suggest that resveratrol, unlike DR, adversely affects hippocampal neurogenesis and cognitive function by a mechanism involving activation of AMPK and suppression of CREB and BDNF signaling.	Resveratrol	26-37	cAMP responsive element binding protein 1	Mus musculus	179-183
22324303-0	2012	The effects of dehydrocostus lactone on osteoblastic MC3T3-E1 cells in redox changes and PI3K/Akt/CREB.	Lactones	29-36	cAMP responsive element binding protein 1	Mus musculus	98-102
23079232-2	2012	The present study aimed to determine the effect of the standardized extract of B. platyphylla bark and its major diarylheptanoids in scopolamine-induced amnesic mice through cyclic AMP response element-binding protein (CREB) activation.	Scopolamine	133-144	cAMP responsive element binding protein 1	Mus musculus	174-217
23079232-2	2012	The present study aimed to determine the effect of the standardized extract of B. platyphylla bark and its major diarylheptanoids in scopolamine-induced amnesic mice through cyclic AMP response element-binding protein (CREB) activation.	Scopolamine	133-144	cAMP responsive element binding protein 1	Mus musculus	219-223
23079232-4	2012	CREB phosphorylation and brain-derived neurotrophic factor (BDNF) expression in the cortex and hippocampus of the scopolamine-treated mice were markedly increased by the treatment of the standardized extract of B. platyphylla bark and platyphylloside.	Scopolamine	114-125	cAMP responsive element binding protein 1	Mus musculus	0-4
23079232-4	2012	CREB phosphorylation and brain-derived neurotrophic factor (BDNF) expression in the cortex and hippocampus of the scopolamine-treated mice were markedly increased by the treatment of the standardized extract of B. platyphylla bark and platyphylloside.	platyphylloside	235-250	cAMP responsive element binding protein 1	Mus musculus	0-4
23079232-6	2012	The standardized extract of B. platyphylla bark and platyphylloside may ameliorate memory deficits by activating the CREB-BDNF pathway and prevent a neurodegeneration by inhibiting neuronal cell death.	platyphylloside	52-67	cAMP responsive element binding protein 1	Mus musculus	117-121
22658979-0	2012	PKA and cAMP stimulate proliferation of mouse embryonic stem cells by elevating GLUT1 expression mediated by the NF-kappaB and CREB/CBP signaling pathways.	Cyclic AMP	8-12	cAMP responsive element binding protein 1	Mus musculus	127-131
22658979-7	2012	6-Phenyl cAMP increased phosphorylation of nuclear factor-kappaB (NF-kappaB) and cAMP response element binding (CREB) and expression of the CREB protein (CBP) and transducer of regulated CREB activity 2 (TORC2) in sequence.	Cyclic AMP	9-13	cAMP responsive element binding protein 1	Mus musculus	112-116
22658979-7	2012	6-Phenyl cAMP increased phosphorylation of nuclear factor-kappaB (NF-kappaB) and cAMP response element binding (CREB) and expression of the CREB protein (CBP) and transducer of regulated CREB activity 2 (TORC2) in sequence.	Cyclic AMP	9-13	cAMP responsive element binding protein 1	Mus musculus	140-144
22658979-7	2012	6-Phenyl cAMP increased phosphorylation of nuclear factor-kappaB (NF-kappaB) and cAMP response element binding (CREB) and expression of the CREB protein (CBP) and transducer of regulated CREB activity 2 (TORC2) in sequence.	Cyclic AMP	9-13	cAMP responsive element binding protein 1	Mus musculus	140-144
22658979-7	2012	6-Phenyl cAMP increased phosphorylation of nuclear factor-kappaB (NF-kappaB) and cAMP response element binding (CREB) and expression of the CREB protein (CBP) and transducer of regulated CREB activity 2 (TORC2) in sequence.	Cyclic AMP	81-85	cAMP responsive element binding protein 1	Mus musculus	112-116
22658979-8	2012	6-Phenyl cAMP induced complex formation of NF-kappaB/CREB/CBP/TORC2, which are involved in the increase of gluconeogenic enzyme expression.	6-phenyl camp	0-13	cAMP responsive element binding protein 1	Mus musculus	53-57
22658979-11	2012	We conclude that PKA stimulated the complex formation of CREB/CBP/TORC2 via NF-kappaB, which induced effective coordination of glucose uptake as well as proliferation in ES cells.	Glucose	127-134	cAMP responsive element binding protein 1	Mus musculus	57-61
23122813-4	2012	FS in cold water also induced phosphorylation of mitogen-activated protein kinase kinase (MEK) as well as of cAMP response element-binding protein (CREB), or dephosphorylation of alpha isoform of Ca(2+)/calmodulin-dependent protein kinase II (alphaCaMKII) in the hippocampus.	phenylalanylserine	0-2	cAMP responsive element binding protein 1	Mus musculus	109-146
23122813-4	2012	FS in cold water also induced phosphorylation of mitogen-activated protein kinase kinase (MEK) as well as of cAMP response element-binding protein (CREB), or dephosphorylation of alpha isoform of Ca(2+)/calmodulin-dependent protein kinase II (alphaCaMKII) in the hippocampus.	phenylalanylserine	0-2	cAMP responsive element binding protein 1	Mus musculus	148-152
23122813-4	2012	FS in cold water also induced phosphorylation of mitogen-activated protein kinase kinase (MEK) as well as of cAMP response element-binding protein (CREB), or dephosphorylation of alpha isoform of Ca(2+)/calmodulin-dependent protein kinase II (alphaCaMKII) in the hippocampus.	Water	11-16	cAMP responsive element binding protein 1	Mus musculus	109-146
23122813-4	2012	FS in cold water also induced phosphorylation of mitogen-activated protein kinase kinase (MEK) as well as of cAMP response element-binding protein (CREB), or dephosphorylation of alpha isoform of Ca(2+)/calmodulin-dependent protein kinase II (alphaCaMKII) in the hippocampus.	Water	11-16	cAMP responsive element binding protein 1	Mus musculus	148-152
22592058-3	2012	The transcription factor cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) and the neurotrophin brain-derived neurotrophic factor (BDNF) have been implicated in rodent models of depression.	Cyclic AMP	25-55	cAMP responsive element binding protein 1	Mus musculus	97-101
22592058-3	2012	The transcription factor cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) and the neurotrophin brain-derived neurotrophic factor (BDNF) have been implicated in rodent models of depression.	Cyclic AMP	57-61	cAMP responsive element binding protein 1	Mus musculus	97-101
22324303-1	2012	Antimycin A (AMA) inhibits mitochondrial electron transport chain between cytochrome b and c. In the present study, we investigated the effects of dehydrocostus lactone on osteoblastic MC3T3-E1 cells in the presence of AMA with a focus on redox changes and PI3K/Akt/CREB signaling.	Antimycin A	0-11	cAMP responsive element binding protein 1	Mus musculus	266-270
22324303-1	2012	Antimycin A (AMA) inhibits mitochondrial electron transport chain between cytochrome b and c. In the present study, we investigated the effects of dehydrocostus lactone on osteoblastic MC3T3-E1 cells in the presence of AMA with a focus on redox changes and PI3K/Akt/CREB signaling.	Antimycin A	13-16	cAMP responsive element binding protein 1	Mus musculus	266-270
22324303-5	2012	These results suggest that antioxidant activity and PI3K/Akt/CREB activation are related to the protective effect of dehydrocostus lactone against osteoblast damage induced by AMA.	Lactones	131-138	cAMP responsive element binding protein 1	Mus musculus	61-65
22668780-9	2012	Moreover, both NMDAR-mediated apoptosis and CREB-off signaling are blocked by co-application of either memantine or the GluN2B subunit-selective antagonist ifenprodil in YAC128 MSNs.	Memantine	103-112	cAMP responsive element binding protein 1	Mus musculus	44-48
22945629-4	2012	We found that the transcription factor FOXO1 is a crucial determinant of the effects of duodenum-derived serotonin on bone formation We identified two key FOXO1 complexes in osteoblasts, one with the transcription factor cAMP-responsive element-binding protein 1 (CREB) and another with activating transcription factor 4 (ATF4).	Serotonin	105-114	cAMP responsive element binding protein 1	Mus musculus	221-262
22945629-4	2012	We found that the transcription factor FOXO1 is a crucial determinant of the effects of duodenum-derived serotonin on bone formation We identified two key FOXO1 complexes in osteoblasts, one with the transcription factor cAMP-responsive element-binding protein 1 (CREB) and another with activating transcription factor 4 (ATF4).	Serotonin	105-114	cAMP responsive element binding protein 1	Mus musculus	264-268
22945629-5	2012	Under normal levels of circulating serotonin, the proliferative activity of FOXO1 was promoted by a balance between its interaction with CREB and ATF4.	Serotonin	35-44	cAMP responsive element binding protein 1	Mus musculus	137-141
22945629-6	2012	However, high circulating serotonin levels prevented the association of FOXO1 with CREB, resulting in suppressed osteoblast proliferation.	Serotonin	26-35	cAMP responsive element binding protein 1	Mus musculus	83-87
22668780-9	2012	Moreover, both NMDAR-mediated apoptosis and CREB-off signaling are blocked by co-application of either memantine or the GluN2B subunit-selective antagonist ifenprodil in YAC128 MSNs.	ifenprodil	156-166	cAMP responsive element binding protein 1	Mus musculus	44-48
22766494-8	2012	Interestingly, we found that ar-turmerone induced phosphorylation of CREB by upregulating the cAMP level in microglial cells.	ar-turmerone	29-41	cAMP responsive element binding protein 1	Mus musculus	69-73
22766494-8	2012	Interestingly, we found that ar-turmerone induced phosphorylation of CREB by upregulating the cAMP level in microglial cells.	Cyclic AMP	94-98	cAMP responsive element binding protein 1	Mus musculus	69-73
22811469-0	2012	Sertoli-secreted FGF-2 induces PFKFB4 isozyme expression in mouse spermatogenic cells by activation of the MEK/ERK/CREB pathway.	sertoli	0-7	cAMP responsive element binding protein 1	Mus musculus	115-119
22742873-9	2012	Moreover, Ipt and Flx enhanced the phosphorylation of Akt and CREB in the hippocampus of Kir6.1(+/+) mice.	N-(1-methylethyl)-1,1,2-trimethylpropylamine	10-13	cAMP responsive element binding protein 1	Mus musculus	62-66
22811470-13	2012	We suggest that the weight-sparing benefit of d-INS in mice is related to its intestinal tissues preference that leads to profound stimulation of Gcg expression and enhanced GLP-1 secretion in intestinal L cells, potentially involving the activation of insulin/beta-catenin/CREB signaling pathways.	d-ins	46-51	cAMP responsive element binding protein 1	Mus musculus	274-278
22742873-9	2012	Moreover, Ipt and Flx enhanced the phosphorylation of Akt and CREB in the hippocampus of Kir6.1(+/+) mice.	Fluoxetine	18-21	cAMP responsive element binding protein 1	Mus musculus	62-66
22742873-11	2012	CONCLUSIONS: Our findings demonstrate that Ipt stimulates the adult hippocampal neurogenesis via activation of Akt and CREB signal following the opening of Kir6.1-composed K-ATP channels, which gives us an insight into the therapeutic implication of Ipt in the diseases with adult neurogenesis deficiency, such as major depression.	N-(1-methylethyl)-1,1,2-trimethylpropylamine	43-46	cAMP responsive element binding protein 1	Mus musculus	119-123
23282170-9	2012	Along with behavioral antidepressant-like effects on the ASC mice, BDNF increased hippocampal mRNA levels of Bdnf and Creb1 (cAMP response element-binding protein gene).	Cyclic AMP	125-129	cAMP responsive element binding protein 1	Mus musculus	118-123
22610792-7	2012	The addition of the protein kinase G (PKG) inhibitor, KT-5823, restored the VEGF-stimulated activation of MAPKs, AP-1, and CREB, demonstrating the integral role of cGMP/PKG signaling in NPRA-mediated effects.	Cyclic GMP	164-168	cAMP responsive element binding protein 1	Mus musculus	123-127
23028378-0	2012	TCF7L2 modulates glucose homeostasis by regulating CREB- and FoxO1-dependent transcriptional pathway in the liver.	Glucose	17-24	cAMP responsive element binding protein 1	Mus musculus	51-55
21538410-6	2012	Apocynin also induced the activation of PI3K (phosphoinositide 3-kinase), Akt (protein kinase B) and CREB (cAMP-response element-binding protein) inhibited by AMA.	acetovanillone	0-8	cAMP responsive element binding protein 1	Mus musculus	101-105
21538410-6	2012	Apocynin also induced the activation of PI3K (phosphoinositide 3-kinase), Akt (protein kinase B) and CREB (cAMP-response element-binding protein) inhibited by AMA.	acetovanillone	0-8	cAMP responsive element binding protein 1	Mus musculus	107-144
22895714-7	2012	In contrast, basal and postovariectomy LH levels were abnormal in GnRH-CREB KO/global-CREM KO mice.	Luteinizing Hormone	39-41	cAMP responsive element binding protein 1	Mus musculus	71-75
22388350-4	2012	We show that Mdm2 is required for cAMP-mediated induction of CCAAT/enhancer-binding protein delta (C/EBPdelta) expression by facilitating recruitment of the cAMP regulatory element-binding protein (CREB) coactivator, CREB-regulated transcription coactivator (Crtc2)/TORC2, to the c/ebpdelta promoter.	Cyclic AMP	34-38	cAMP responsive element binding protein 1	Mus musculus	157-196
22449479-7	2012	Further studies are needed to examine the effect of chronic fluoxetine treatment on the ERK-CREB system, and to determine whether there is a causal relationship between the disruption of the ERK-CREB system and the effect of this antidepressant on memory performance.	Fluoxetine	60-70	cAMP responsive element binding protein 1	Mus musculus	92-96
22388350-4	2012	We show that Mdm2 is required for cAMP-mediated induction of CCAAT/enhancer-binding protein delta (C/EBPdelta) expression by facilitating recruitment of the cAMP regulatory element-binding protein (CREB) coactivator, CREB-regulated transcription coactivator (Crtc2)/TORC2, to the c/ebpdelta promoter.	Cyclic AMP	34-38	cAMP responsive element binding protein 1	Mus musculus	198-202
22388350-4	2012	We show that Mdm2 is required for cAMP-mediated induction of CCAAT/enhancer-binding protein delta (C/EBPdelta) expression by facilitating recruitment of the cAMP regulatory element-binding protein (CREB) coactivator, CREB-regulated transcription coactivator (Crtc2)/TORC2, to the c/ebpdelta promoter.	Cyclic AMP	34-38	cAMP responsive element binding protein 1	Mus musculus	217-221
22815537-2	2012	The transcription factor CREB (cAMP response element binding protein) is required for memory formation and in vitro dendritic spine rearrangements, but its role in learning-induced remodeling of neurons remains elusive.	Cyclic AMP	31-35	cAMP responsive element binding protein 1	Mus musculus	25-29
22441938-3	2012	We found that PDE5 inhibitor (sildenafil or vardenafil) and the cGMP analog 8-CPT-cGMP stimulated CREB phosphorylation, leading to increased tyrosinase expression and melanin synthesis, which was counteracted by KT5823, a selective cGMP-dependent protein kinase (PKG) inhibitor.	Sildenafil Citrate	30-40	cAMP responsive element binding protein 1	Mus musculus	98-102
22441938-3	2012	We found that PDE5 inhibitor (sildenafil or vardenafil) and the cGMP analog 8-CPT-cGMP stimulated CREB phosphorylation, leading to increased tyrosinase expression and melanin synthesis, which was counteracted by KT5823, a selective cGMP-dependent protein kinase (PKG) inhibitor.	Vardenafil Dihydrochloride	44-54	cAMP responsive element binding protein 1	Mus musculus	98-102
22441938-3	2012	We found that PDE5 inhibitor (sildenafil or vardenafil) and the cGMP analog 8-CPT-cGMP stimulated CREB phosphorylation, leading to increased tyrosinase expression and melanin synthesis, which was counteracted by KT5823, a selective cGMP-dependent protein kinase (PKG) inhibitor.	Cyclic GMP	64-68	cAMP responsive element binding protein 1	Mus musculus	98-102
22441938-3	2012	We found that PDE5 inhibitor (sildenafil or vardenafil) and the cGMP analog 8-CPT-cGMP stimulated CREB phosphorylation, leading to increased tyrosinase expression and melanin synthesis, which was counteracted by KT5823, a selective cGMP-dependent protein kinase (PKG) inhibitor.	8-((4-chlorophenyl)thio)cyclic-3',5'-GMP	76-86	cAMP responsive element binding protein 1	Mus musculus	98-102
22441938-3	2012	We found that PDE5 inhibitor (sildenafil or vardenafil) and the cGMP analog 8-CPT-cGMP stimulated CREB phosphorylation, leading to increased tyrosinase expression and melanin synthesis, which was counteracted by KT5823, a selective cGMP-dependent protein kinase (PKG) inhibitor.	Melanins	167-174	cAMP responsive element binding protein 1	Mus musculus	98-102
22441938-3	2012	We found that PDE5 inhibitor (sildenafil or vardenafil) and the cGMP analog 8-CPT-cGMP stimulated CREB phosphorylation, leading to increased tyrosinase expression and melanin synthesis, which was counteracted by KT5823, a selective cGMP-dependent protein kinase (PKG) inhibitor.	KT 5823	212-218	cAMP responsive element binding protein 1	Mus musculus	98-102
22441938-5	2012	This is the first study to find that PDE5 inhibitor can promote melanin synthesis and reveal that PKG-dependent CREB phosphorylation and tyrosinase expression is involved in cGMP-induced melanin synthesis.	Cyclic GMP	174-178	cAMP responsive element binding protein 1	Mus musculus	112-116
22441938-5	2012	This is the first study to find that PDE5 inhibitor can promote melanin synthesis and reveal that PKG-dependent CREB phosphorylation and tyrosinase expression is involved in cGMP-induced melanin synthesis.	Melanins	187-194	cAMP responsive element binding protein 1	Mus musculus	112-116
22775220-11	2012	In the PGE(2)-stimulated melanocytes, mRNA expressions of EP-1, Tyr and Tyrp1 and phosphorylation of CREB protein were suppressed.	Dinoprostone	7-13	cAMP responsive element binding protein 1	Mus musculus	101-105
22815537-5	2012	Blocking mCREB expression with doxycycline rescued memory and restored a normal pattern of learning-induced spines, demonstrating that CREB controls structural adaptations of neurons selectively involved in memory formation.	Doxycycline	31-42	cAMP responsive element binding protein 1	Mus musculus	9-14
22815537-5	2012	Blocking mCREB expression with doxycycline rescued memory and restored a normal pattern of learning-induced spines, demonstrating that CREB controls structural adaptations of neurons selectively involved in memory formation.	Doxycycline	31-42	cAMP responsive element binding protein 1	Mus musculus	10-14
22706077-10	2012	Taken together, these results highlight the importance of the PI3K-Akt-CREB pathway in mediating gem-induced upregulation of IL-1Ra in neurons and suggest gem as a possible therapeutic treatment for propagating neuronal self-defense in neuroinflammatory and neurodegenerative disorders.	Gemfibrozil	97-100	cAMP responsive element binding protein 1	Mus musculus	71-75
22492943-10	2012	Phosphorylation of the cAMP-induced transcription factor CREB was decreased in PKC-alpha(-/-) mice in response to ANG II with no change in overall CREB abundance.	Cyclic AMP	23-27	cAMP responsive element binding protein 1	Mus musculus	57-61
22706077-7	2012	Gem also induced the activation of CREB via the PI3K-Akt pathway, and small interfering RNA attenuation of CREB abolished the gem-mediated increase in IL-1Ra.	Gemfibrozil	126-129	cAMP responsive element binding protein 1	Mus musculus	35-39
22706077-7	2012	Gem also induced the activation of CREB via the PI3K-Akt pathway, and small interfering RNA attenuation of CREB abolished the gem-mediated increase in IL-1Ra.	Gemfibrozil	126-129	cAMP responsive element binding protein 1	Mus musculus	107-111
22454534-4	2012	Previous studies with glioma cell lines such as NG108-15 cells attributed morphine-induced gene expression to the activation of the cAMP-responsive element binding protein (CREB).	Morphine	74-82	cAMP responsive element binding protein 1	Mus musculus	132-171
22610350-0	2012	Olprinone and colforsin daropate alleviate septic lung inflammation and apoptosis through CREB-independent activation of the Akt pathway.	olprinone	0-9	cAMP responsive element binding protein 1	Mus musculus	90-94
22610350-9	2012	In vivo transfection of cyclic AMP response element binding protein (CREB) decoy oligodeoxynucleotide failed to negate the abilities of these agents to increase Akt phosphorylation and to inhibit IkappaBalpha degradation in septic lungs.	Oligodeoxyribonucleotides	81-101	cAMP responsive element binding protein 1	Mus musculus	69-73
22610350-10	2012	These results demonstrate for the first time that CREB-independent Akt-mediated signaling is a critical mechanism contributing to the therapeutic effects of olprinone and corforsin daropate on septic ALI.	olprinone	157-166	cAMP responsive element binding protein 1	Mus musculus	50-54
22564151-0	2012	RGS10 exerts a neuroprotective role through the PKA/c-AMP response-element (CREB) pathway in dopaminergic neuron-like cells.	Adenosine Monophosphate	54-57	cAMP responsive element binding protein 1	Mus musculus	76-80
22454534-6	2012	In contrast to the CREB stimulation found in NG108-15 cells, we observed an inhibitory effect of morphine in F11 cells, indicating cell type-specific regulation of CREB by morphine.	Morphine	172-180	cAMP responsive element binding protein 1	Mus musculus	164-168
22454534-4	2012	Previous studies with glioma cell lines such as NG108-15 cells attributed morphine-induced gene expression to the activation of the cAMP-responsive element binding protein (CREB).	Morphine	74-82	cAMP responsive element binding protein 1	Mus musculus	173-177
22454534-5	2012	Thus, we also analyzed morphine-dependent activation of CREB in F11 and NG108-15 cells.	Morphine	23-31	cAMP responsive element binding protein 1	Mus musculus	56-60
22564436-10	2012	OT also increased cAMP response element-binding (CREB)/CREB-binding protein (CBP) expression in the nucleus and induced the formation of CREB1/NF-kappaB/CBP complexes, which was blocked by the NF-kappaB-specific small interfering RNA, NF-kappaB inhibitors, SN50, and bay11-7082.	3-(4-methylphenylsulfonyl)-2-propenenitrile	267-277	cAMP responsive element binding protein 1	Mus musculus	18-47
22564436-10	2012	OT also increased cAMP response element-binding (CREB)/CREB-binding protein (CBP) expression in the nucleus and induced the formation of CREB1/NF-kappaB/CBP complexes, which was blocked by the NF-kappaB-specific small interfering RNA, NF-kappaB inhibitors, SN50, and bay11-7082.	3-(4-methylphenylsulfonyl)-2-propenenitrile	267-277	cAMP responsive element binding protein 1	Mus musculus	49-53
22564436-10	2012	OT also increased cAMP response element-binding (CREB)/CREB-binding protein (CBP) expression in the nucleus and induced the formation of CREB1/NF-kappaB/CBP complexes, which was blocked by the NF-kappaB-specific small interfering RNA, NF-kappaB inhibitors, SN50, and bay11-7082.	3-(4-methylphenylsulfonyl)-2-propenenitrile	267-277	cAMP responsive element binding protein 1	Mus musculus	137-142
22484357-10	2012	These findings suggest that BPA exposure of pregnant mothers could adversely affect hippocampal neurogenesis and cognitive function in future generations by modulating the ERK and BDNF-CREB signaling cascades.	bisphenol A	28-31	cAMP responsive element binding protein 1	Mus musculus	185-189
22542942-3	2012	Here we show that nociceptin, known as a neuropeptide, is upregulated by FSH through cAMP/PKA/CREB pathway in Sertoli cells in murine testes.	Cyclic AMP	85-89	cAMP responsive element binding protein 1	Mus musculus	94-98
21903156-10	2012	However, the attenuation of IBMX-mediated up-regulations of phospho-CREB and phospho-PKA was readily observed with 60 min of QW treatment.	1-Methyl-3-isobutylxanthine	28-32	cAMP responsive element binding protein 1	Mus musculus	68-72
22290937-6	2012	Liver protection due to cAMP-PKA stimulation was accompanied by diminished neutrophil and macrophage infiltration/activation, reduced hepatocyte necrosis/apoptosis, and increased cAMP response element-binding protein (CREB) expression and augmented interleukin-10 (IL-10) expression.	Cyclic AMP	24-28	cAMP responsive element binding protein 1	Mus musculus	179-216
22290937-6	2012	Liver protection due to cAMP-PKA stimulation was accompanied by diminished neutrophil and macrophage infiltration/activation, reduced hepatocyte necrosis/apoptosis, and increased cAMP response element-binding protein (CREB) expression and augmented interleukin-10 (IL-10) expression.	Cyclic AMP	24-28	cAMP responsive element binding protein 1	Mus musculus	218-222
22281543-8	2012	Pretreatment with magnolol prior to antimycin A exposure significantly reduced antimycin A-induced osteoblast dysfunction by preventing MMP dissipation, ATP loss, and CREB inactivation.	magnolol	18-26	cAMP responsive element binding protein 1	Mus musculus	167-171
22649236-0	2012	Serum response factor and cAMP response element binding protein are both required for cocaine induction of DeltaFosB.	Cocaine	86-93	cAMP responsive element binding protein 1	Mus musculus	26-63
22649236-3	2012	CREB and SRF are both activated in NAc by cocaine and bind to the fosB gene promoter.	Cocaine	42-49	cAMP responsive element binding protein 1	Mus musculus	0-4
22649236-5	2012	Furthermore, deletion of both SRF and CREB from NAc renders animals less sensitive to the rewarding effects of moderate doses of cocaine when tested in the conditioned place preference (CPP) procedure and also blocks locomotor sensitization to higher doses of cocaine.	Cocaine	129-136	cAMP responsive element binding protein 1	Mus musculus	38-42
22649236-5	2012	Furthermore, deletion of both SRF and CREB from NAc renders animals less sensitive to the rewarding effects of moderate doses of cocaine when tested in the conditioned place preference (CPP) procedure and also blocks locomotor sensitization to higher doses of cocaine.	Cocaine	260-267	cAMP responsive element binding protein 1	Mus musculus	38-42
22649236-6	2012	Deletion of CREB alone has the opposite effect and enhances both cocaine CPP and locomotor sensitization.	Cocaine	65-72	cAMP responsive element binding protein 1	Mus musculus	12-16
22649236-9	2012	Our results also establish a complex mode of regulation of DeltaFosB induction in response to cocaine, which requires the concerted activities of both SRF and CREB.	Cocaine	94-101	cAMP responsive element binding protein 1	Mus musculus	159-163
22607375-3	2012	The function of CREB as a transcriptional activator is controlled by its phosphorylation on serine 133, which can be catalyzed by CaMKIV and leads to the recruitment of the co-activator, CREB binding protein (CBP).	Serine	92-98	cAMP responsive element binding protein 1	Mus musculus	16-20
22607375-5	2012	RESULTS: Here we used recombinant adeno-associated virus (rAAV) to increase the levels of wild type CREB or to overexpress a mutant version of CREB (mCREB) containing a serine to alanine mutation at position amino acid 133 in mouse hippocampal neurons.	Serine	169-175	cAMP responsive element binding protein 1	Mus musculus	143-147
22607375-5	2012	RESULTS: Here we used recombinant adeno-associated virus (rAAV) to increase the levels of wild type CREB or to overexpress a mutant version of CREB (mCREB) containing a serine to alanine mutation at position amino acid 133 in mouse hippocampal neurons.	Serine	169-175	cAMP responsive element binding protein 1	Mus musculus	149-154
22086359-0	2012	CREB involvement in the regulation of striatal prodynorphin by nicotine.	Nicotine	63-71	cAMP responsive element binding protein 1	Mus musculus	0-4
22607375-5	2012	RESULTS: Here we used recombinant adeno-associated virus (rAAV) to increase the levels of wild type CREB or to overexpress a mutant version of CREB (mCREB) containing a serine to alanine mutation at position amino acid 133 in mouse hippocampal neurons.	Alanine	179-186	cAMP responsive element binding protein 1	Mus musculus	143-147
22607375-5	2012	RESULTS: Here we used recombinant adeno-associated virus (rAAV) to increase the levels of wild type CREB or to overexpress a mutant version of CREB (mCREB) containing a serine to alanine mutation at position amino acid 133 in mouse hippocampal neurons.	Alanine	179-186	cAMP responsive element binding protein 1	Mus musculus	149-154
22607375-8	2012	The ratio of phospho(serine 133)CREB to CREB immunoreactivity in unstimulated hippocampal neurons was similar for endogenous CREB and overexpressed wild type CREB and, as expected, dramatically reduced for overexpressed mCREB.	Serine	21-27	cAMP responsive element binding protein 1	Mus musculus	32-36
22607375-12	2012	The observed degradation of CREB protein following NMDA treatment of hippocampal neurons suggests that the known CREB shut-off associated with extrasynaptic NMDA receptor-induced excitotoxicity is followed by CREB proteolysis.	N-Methylaspartate	51-55	cAMP responsive element binding protein 1	Mus musculus	28-32
22607375-12	2012	The observed degradation of CREB protein following NMDA treatment of hippocampal neurons suggests that the known CREB shut-off associated with extrasynaptic NMDA receptor-induced excitotoxicity is followed by CREB proteolysis.	N-Methylaspartate	51-55	cAMP responsive element binding protein 1	Mus musculus	113-117
22607375-12	2012	The observed degradation of CREB protein following NMDA treatment of hippocampal neurons suggests that the known CREB shut-off associated with extrasynaptic NMDA receptor-induced excitotoxicity is followed by CREB proteolysis.	N-Methylaspartate	51-55	cAMP responsive element binding protein 1	Mus musculus	113-117
22579288-3	2012	BMP8B is induced by nutritional and thermogenic factors in mature BAT, increasing the response to noradrenaline through enhanced p38MAPK/CREB signaling and increased lipase activity.	Norepinephrine	98-111	cAMP responsive element binding protein 1	Mus musculus	137-141
22427515-1	2012	The cAMP response element binding protein (CREB) belongs to the CREB/cAMP response element binding modulator/activating transcription factor 1 family of cAMP-dependent transcription factors mediating a regulation of gene transcription in response to cAMP.	Cyclic AMP	4-8	cAMP responsive element binding protein 1	Mus musculus	43-47
22427515-1	2012	The cAMP response element binding protein (CREB) belongs to the CREB/cAMP response element binding modulator/activating transcription factor 1 family of cAMP-dependent transcription factors mediating a regulation of gene transcription in response to cAMP.	Cyclic AMP	4-8	cAMP responsive element binding protein 1	Mus musculus	64-68
22427515-1	2012	The cAMP response element binding protein (CREB) belongs to the CREB/cAMP response element binding modulator/activating transcription factor 1 family of cAMP-dependent transcription factors mediating a regulation of gene transcription in response to cAMP.	Cyclic AMP	69-73	cAMP responsive element binding protein 1	Mus musculus	4-41
22427515-1	2012	The cAMP response element binding protein (CREB) belongs to the CREB/cAMP response element binding modulator/activating transcription factor 1 family of cAMP-dependent transcription factors mediating a regulation of gene transcription in response to cAMP.	Cyclic AMP	69-73	cAMP responsive element binding protein 1	Mus musculus	43-47
22427515-1	2012	The cAMP response element binding protein (CREB) belongs to the CREB/cAMP response element binding modulator/activating transcription factor 1 family of cAMP-dependent transcription factors mediating a regulation of gene transcription in response to cAMP.	Cyclic AMP	69-73	cAMP responsive element binding protein 1	Mus musculus	64-68
22427515-1	2012	The cAMP response element binding protein (CREB) belongs to the CREB/cAMP response element binding modulator/activating transcription factor 1 family of cAMP-dependent transcription factors mediating a regulation of gene transcription in response to cAMP.	Cyclic AMP	69-73	cAMP responsive element binding protein 1	Mus musculus	4-41
22427515-1	2012	The cAMP response element binding protein (CREB) belongs to the CREB/cAMP response element binding modulator/activating transcription factor 1 family of cAMP-dependent transcription factors mediating a regulation of gene transcription in response to cAMP.	Cyclic AMP	69-73	cAMP responsive element binding protein 1	Mus musculus	43-47
22427515-1	2012	The cAMP response element binding protein (CREB) belongs to the CREB/cAMP response element binding modulator/activating transcription factor 1 family of cAMP-dependent transcription factors mediating a regulation of gene transcription in response to cAMP.	Cyclic AMP	69-73	cAMP responsive element binding protein 1	Mus musculus	64-68
22427515-10	2012	Our results from mice with cardiomyocyte-specific inactivation of CREB definitively indicate that CREB critically regulates the AP shape and duration in the mouse ventricle, which might have an impact on ion channel remodeling in situations of altered cAMP-dependent signaling like heart failure.	Cyclic AMP	252-256	cAMP responsive element binding protein 1	Mus musculus	66-70
22427515-10	2012	Our results from mice with cardiomyocyte-specific inactivation of CREB definitively indicate that CREB critically regulates the AP shape and duration in the mouse ventricle, which might have an impact on ion channel remodeling in situations of altered cAMP-dependent signaling like heart failure.	Cyclic AMP	252-256	cAMP responsive element binding protein 1	Mus musculus	98-102
22375007-8	2012	Notably, expression of CREB target genes that regulate testosterone biosynthesis was reduced in Mrp4(-/-) Leydig cells in vivo.	Testosterone	55-67	cAMP responsive element binding protein 1	Mus musculus	23-27
22086359-2	2012	CREB phosphorylation at Ser133 is enhanced by drugs of abuse, including nicotine.	Nicotine	72-80	cAMP responsive element binding protein 1	Mus musculus	0-4
22086359-6	2012	RESULTS: Acute nicotine increased adenylyl cyclase activity, cAMP, and pCREB Ser133 levels in striatum and enhanced CREB binding to CRE elements (DynCREs) of the PD promoter, preferentially DynCRE3.	Nicotine	15-23	cAMP responsive element binding protein 1	Mus musculus	72-76
22086359-11	2012	CONCLUSIONS: Our findings suggest that nicotine regulates PD expression in striatum at the transcriptional level and CREB is involved.	Nicotine	39-47	cAMP responsive element binding protein 1	Mus musculus	117-121
22116937-6	2012	Finally, and consistent with a role of CBP in cognitive impairment in Hdh(Q7/Q111) mice, administration of the histone deacetylase inhibitor trichostatin A rescues recognition memory deficits and transcription of selective CREB/CBP target genes in Hdh(Q7/Q111) mice.	trichostatin A	141-155	cAMP responsive element binding protein 1	Mus musculus	223-227
22267179-3	2012	When transcribed in vitro, while Ser-133 phosphorylation of KID was maintained upon forskolin treatment, mutated CREB1 protein failed to associate with the KIX domain of co-activator CREBBP/EP300, and thereby, interrupted cAMP-dependent protein kinase A signal transduction as the dominant-negative form.	Cyclic AMP	222-226	cAMP responsive element binding protein 1	Mus musculus	113-118
22495310-2	2012	Triggering of the cyclic AMP pathway increases gluconeogenic gene expression via the de-phosphorylation of the CREB co-activator CRTC2 (ref.	Cyclic AMP	18-28	cAMP responsive element binding protein 1	Mus musculus	111-115
22172985-7	2012	In addition, nobiletin decreased the phosphorylation of cAMP-response element-binding protein (CREB) and strongly enhanced the phophorylation of signal transducer and activator of transcription (STAT) 5.	nobiletin	13-22	cAMP responsive element binding protein 1	Mus musculus	56-93
22172985-7	2012	In addition, nobiletin decreased the phosphorylation of cAMP-response element-binding protein (CREB) and strongly enhanced the phophorylation of signal transducer and activator of transcription (STAT) 5.	nobiletin	13-22	cAMP responsive element binding protein 1	Mus musculus	95-99
21665879-10	2012	The study also reveals that nomilin could inhibit the activation and nuclear translocation of antiapoptotic transcription factors such as nuclear factor (NF)-kappaB, CREB, and ATF-2 in B16F-10 cells.	nomilin	28-35	cAMP responsive element binding protein 1	Mus musculus	166-170
22315325-9	2012	Glucagon action was examined using glucagon tolerance tests and glucagon-stimulated HGP, cAMP-responsive element-binding (CREB) phosphorylation, and expression of gluconeogenic genes in the liver and primary hepatocytes.	Glucagon	0-8	cAMP responsive element binding protein 1	Mus musculus	122-126
22315325-9	2012	Glucagon action was examined using glucagon tolerance tests and glucagon-stimulated HGP, cAMP-responsive element-binding (CREB) phosphorylation, and expression of gluconeogenic genes in the liver and primary hepatocytes.	Glucagon	64-72	cAMP responsive element binding protein 1	Mus musculus	122-126
22315325-14	2012	In addition, TRAF2 overexpression significantly increased the ability of glucagon or a cAMP analog to stimulate CREB phosphorylation, gluconeogenic gene expression, and HGP in primary hepatocytes.	Glucagon	73-81	cAMP responsive element binding protein 1	Mus musculus	112-116
22266363-8	2012	Moreover, hesperetin stimulated the activation of mitogen-activated protein kinases (MAPKs), phosphorylation of cAMP-responsive element binding protein (CREB) and glycogen synthase kinase-3beta (GSK3beta), and subsequently induced the accumulation of beta-catenin.	hesperetin	10-20	cAMP responsive element binding protein 1	Mus musculus	112-151
22266363-8	2012	Moreover, hesperetin stimulated the activation of mitogen-activated protein kinases (MAPKs), phosphorylation of cAMP-responsive element binding protein (CREB) and glycogen synthase kinase-3beta (GSK3beta), and subsequently induced the accumulation of beta-catenin.	hesperetin	10-20	cAMP responsive element binding protein 1	Mus musculus	153-157
22173129-8	2012	In addition, the expression levels of phosphorylated ERK and CREB in the hippocampus were significantly increased by stigmasterol, which was blocked by tamoxifen or MK-801 with scopolamine.	Scopolamine	177-188	cAMP responsive element binding protein 1	Mus musculus	61-65
22279136-7	2012	Our results indicated that LI2 was sufficient to drive preadipocyte differentiation via modulating the phosphorylation level and transcriptional activity of CREB, coincident with expression of several adipogenic regulators and mature adipocyte markers, without insulin treatment.	li2	27-30	cAMP responsive element binding protein 1	Mus musculus	157-161
21913972-7	2012	We also demonstrate that melatonin treatment decreased CREB, ATF-1, and p38 phosphorylation in both mt1/2(-/-)  and WT mice, while p21 and JNK1/2 were reduced only in melatonin-treated WT animals in the ischemic hemisphere.	Melatonin	25-34	cAMP responsive element binding protein 1	Mus musculus	55-59
22197517-9	2012	Repeated cocaine reduced GluR1, GluR2 and CREB expression in the NAc, and reductions of GluR1 and GluR2 but not CREB were further enhanced by ICSS.	Cocaine	9-16	cAMP responsive element binding protein 1	Mus musculus	42-46
22173129-8	2012	In addition, the expression levels of phosphorylated ERK and CREB in the hippocampus were significantly increased by stigmasterol, which was blocked by tamoxifen or MK-801 with scopolamine.	Stigmasterol	117-129	cAMP responsive element binding protein 1	Mus musculus	61-65
22020741-11	2012	Using Western blotting, we found             that adenosine stimulated phosphorylation of ERK, CREB and AKT.	Adenosine	50-59	cAMP responsive element binding protein 1	Mus musculus	95-99
22173129-8	2012	In addition, the expression levels of phosphorylated ERK and CREB in the hippocampus were significantly increased by stigmasterol, which was blocked by tamoxifen or MK-801 with scopolamine.	Tamoxifen	152-161	cAMP responsive element binding protein 1	Mus musculus	61-65
22173129-8	2012	In addition, the expression levels of phosphorylated ERK and CREB in the hippocampus were significantly increased by stigmasterol, which was blocked by tamoxifen or MK-801 with scopolamine.	Dizocilpine Maleate	165-171	cAMP responsive element binding protein 1	Mus musculus	61-65
21955519-2	2012	We have shown that non-small cell lung cancer (NSCLC) cells in vitro are stimulated by the cyclic AMP (cAMP)-dependent activation of cAMP-responsive element binding protein (CREB) and extracellular signal-regulated kinase (ERK) downstream of beta-adrenergic receptors and that this pathway is inhibited by the neurotransmitter gamma-aminobutyric acid (GABA).	Cyclic AMP	91-101	cAMP responsive element binding protein 1	Mus musculus	133-172
21955519-2	2012	We have shown that non-small cell lung cancer (NSCLC) cells in vitro are stimulated by the cyclic AMP (cAMP)-dependent activation of cAMP-responsive element binding protein (CREB) and extracellular signal-regulated kinase (ERK) downstream of beta-adrenergic receptors and that this pathway is inhibited by the neurotransmitter gamma-aminobutyric acid (GABA).	Cyclic AMP	91-101	cAMP responsive element binding protein 1	Mus musculus	174-178
21955519-2	2012	We have shown that non-small cell lung cancer (NSCLC) cells in vitro are stimulated by the cyclic AMP (cAMP)-dependent activation of cAMP-responsive element binding protein (CREB) and extracellular signal-regulated kinase (ERK) downstream of beta-adrenergic receptors and that this pathway is inhibited by the neurotransmitter gamma-aminobutyric acid (GABA).	Cyclic AMP	103-107	cAMP responsive element binding protein 1	Mus musculus	133-172
21955519-2	2012	We have shown that non-small cell lung cancer (NSCLC) cells in vitro are stimulated by the cyclic AMP (cAMP)-dependent activation of cAMP-responsive element binding protein (CREB) and extracellular signal-regulated kinase (ERK) downstream of beta-adrenergic receptors and that this pathway is inhibited by the neurotransmitter gamma-aminobutyric acid (GABA).	Cyclic AMP	103-107	cAMP responsive element binding protein 1	Mus musculus	174-178
21955519-2	2012	We have shown that non-small cell lung cancer (NSCLC) cells in vitro are stimulated by the cyclic AMP (cAMP)-dependent activation of cAMP-responsive element binding protein (CREB) and extracellular signal-regulated kinase (ERK) downstream of beta-adrenergic receptors and that this pathway is inhibited by the neurotransmitter gamma-aminobutyric acid (GABA).	gamma-Aminobutyric Acid	327-350	cAMP responsive element binding protein 1	Mus musculus	133-172
21955519-2	2012	We have shown that non-small cell lung cancer (NSCLC) cells in vitro are stimulated by the cyclic AMP (cAMP)-dependent activation of cAMP-responsive element binding protein (CREB) and extracellular signal-regulated kinase (ERK) downstream of beta-adrenergic receptors and that this pathway is inhibited by the neurotransmitter gamma-aminobutyric acid (GABA).	gamma-Aminobutyric Acid	327-350	cAMP responsive element binding protein 1	Mus musculus	174-178
21955519-2	2012	We have shown that non-small cell lung cancer (NSCLC) cells in vitro are stimulated by the cyclic AMP (cAMP)-dependent activation of cAMP-responsive element binding protein (CREB) and extracellular signal-regulated kinase (ERK) downstream of beta-adrenergic receptors and that this pathway is inhibited by the neurotransmitter gamma-aminobutyric acid (GABA).	gamma-Aminobutyric Acid	352-356	cAMP responsive element binding protein 1	Mus musculus	133-172
21955519-2	2012	We have shown that non-small cell lung cancer (NSCLC) cells in vitro are stimulated by the cyclic AMP (cAMP)-dependent activation of cAMP-responsive element binding protein (CREB) and extracellular signal-regulated kinase (ERK) downstream of beta-adrenergic receptors and that this pathway is inhibited by the neurotransmitter gamma-aminobutyric acid (GABA).	gamma-Aminobutyric Acid	352-356	cAMP responsive element binding protein 1	Mus musculus	174-178
22814256-0	2012	Atorvastatin and simvastatin, but not pravastatin, up-regulate LPS-induced MMP-9 expression in macrophages by regulating phosphorylation of ERK and CREB.	Atorvastatin	0-12	cAMP responsive element binding protein 1	Mus musculus	148-152
22049513-4	2012	Here, we demonstrate that CREB maintains basal endothelial barrier function and suppresses endothelial permeability increase by diverse agonists such as thrombin, lipopolysaccharide, histamine, and VEGF.	Histamine	183-192	cAMP responsive element binding protein 1	Mus musculus	26-30
22088430-6	2012	Sildenafil increased the phosphorylation of cAMP response element-binding protein (CREB) in the hippocampus.	Sildenafil Citrate	0-10	cAMP responsive element binding protein 1	Mus musculus	44-81
22088430-6	2012	Sildenafil increased the phosphorylation of cAMP response element-binding protein (CREB) in the hippocampus.	Sildenafil Citrate	0-10	cAMP responsive element binding protein 1	Mus musculus	83-87
22088430-7	2012	The OTR antagonist inhibited sildenafil-induced CREB phosphorylation and sildenafil had no effect on CREB phosphorylation in OTR KO mice.	Sildenafil Citrate	29-39	cAMP responsive element binding protein 1	Mus musculus	48-52
22628303-2	2012	enhCRE binds the CRE-binding protein (CREB), which is the main transcription factor target of cAMP signaling.	Cyclic AMP	94-98	cAMP responsive element binding protein 1	Mus musculus	17-36
22628303-2	2012	enhCRE binds the CRE-binding protein (CREB), which is the main transcription factor target of cAMP signaling.	Cyclic AMP	94-98	cAMP responsive element binding protein 1	Mus musculus	38-42
22628303-7	2012	In addition, MG132 increased the DNA-binding of ATF2 as well as the ratio of bound ATF2 to CREB.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	13-18	cAMP responsive element binding protein 1	Mus musculus	91-95
22814256-0	2012	Atorvastatin and simvastatin, but not pravastatin, up-regulate LPS-induced MMP-9 expression in macrophages by regulating phosphorylation of ERK and CREB.	Simvastatin	17-28	cAMP responsive element binding protein 1	Mus musculus	148-152
22145808-8	2012	Further, berberine inhibited various transcription factors involved in tumor development and angiogenesis, such as NF-kB, c-Fos, CREB, and ATF-2.	Berberine	9-18	cAMP responsive element binding protein 1	Mus musculus	129-133
22419037-3	2012	We find that the basally-induced decrease in this phosphoprotein is the result of recruitment of the striatal dopamine D2 pathway, as evidenced by enhanced levels of D2 receptor (D2R) mRNA expression and D2R function as examined using the D2R antagonist, eticlopride, as well as alterations in the phosphorylation status of several downstream molecular targets of D2R"s, including CREB, DARPP-32, Akt and GSK3beta.	Dopamine	110-118	cAMP responsive element binding protein 1	Mus musculus	381-385
21972008-6	2012	In the             MITF pathway, the phosphorylation of cAMP related binding protein (CREB) activated             the transcription of MITF, resulting in increasing melanin synthesis.	Melanins	165-172	cAMP responsive element binding protein 1	Mus musculus	56-84
21972008-0	2012	Suppression of alpha-MSH and IBMX-induced melanogenesis by cordycepin via             inhibition of CREB and MITF, and activation of PI3K/Akt and ERK-dependent mechanisms.	1-Methyl-3-isobutylxanthine	29-33	cAMP responsive element binding protein 1	Mus musculus	100-104
21972008-6	2012	In the             MITF pathway, the phosphorylation of cAMP related binding protein (CREB) activated             the transcription of MITF, resulting in increasing melanin synthesis.	Melanins	165-172	cAMP responsive element binding protein 1	Mus musculus	86-90
23196901-8	2012	Further experiments showed that Fuzi total alkaloid enhanced the ratio of phospho-CREB/CREB (cAMP response element-binding) and BDNF (brain-derived neurotrophic factor) protein level in the frontal cortex and hippocampus in ovariectomized mice but not in normal mice.	Alkaloids	43-51	cAMP responsive element binding protein 1	Mus musculus	82-86
22116830-8	2012	Chromatin immunoprecipitation analysis demonstrated that adenosine induced CREB phosphorylation at the IL-10 promoter.	Adenosine	57-66	cAMP responsive element binding protein 1	Mus musculus	75-79
22116830-9	2012	Silencing CREB using lentivirally delivered short hairpin RNA blocked the enhancing effect of adenosine on IL-10 production, confirming a role for CREB in mediating the stimulatory effect of adenosine on IL-10 production.	Adenosine	94-103	cAMP responsive element binding protein 1	Mus musculus	10-14
22116830-9	2012	Silencing CREB using lentivirally delivered short hairpin RNA blocked the enhancing effect of adenosine on IL-10 production, confirming a role for CREB in mediating the stimulatory effect of adenosine on IL-10 production.	Adenosine	191-200	cAMP responsive element binding protein 1	Mus musculus	10-14
22116830-9	2012	Silencing CREB using lentivirally delivered short hairpin RNA blocked the enhancing effect of adenosine on IL-10 production, confirming a role for CREB in mediating the stimulatory effect of adenosine on IL-10 production.	Adenosine	191-200	cAMP responsive element binding protein 1	Mus musculus	147-151
22116830-7	2012	Using mutant IL-10 promoter constructs we showed that a CREB-binding region in the promoter mediated the augmenting effect of adenosine on IL-10 transcription.	Adenosine	126-135	cAMP responsive element binding protein 1	Mus musculus	56-60
23196901-8	2012	Further experiments showed that Fuzi total alkaloid enhanced the ratio of phospho-CREB/CREB (cAMP response element-binding) and BDNF (brain-derived neurotrophic factor) protein level in the frontal cortex and hippocampus in ovariectomized mice but not in normal mice.	Alkaloids	43-51	cAMP responsive element binding protein 1	Mus musculus	87-91
23196901-8	2012	Further experiments showed that Fuzi total alkaloid enhanced the ratio of phospho-CREB/CREB (cAMP response element-binding) and BDNF (brain-derived neurotrophic factor) protein level in the frontal cortex and hippocampus in ovariectomized mice but not in normal mice.	Cyclic AMP	93-97	cAMP responsive element binding protein 1	Mus musculus	87-91
21892690-0	2012	Inhibition of neuron-specific CREB dephosphorylation is involved in propofol and ketamine-induced neuroprotection against cerebral ischemic injuries of mice.	Propofol	68-76	cAMP responsive element binding protein 1	Mus musculus	30-34
21951632-3	2012	Using immunohistochemical analysis of phosphorylated and unphosphorylated cAMP response element-binding protein (CREB), the current set of experiments first showed that the prelimbic (PL) and infralimbic (IL) subregions of the mPFC exhibited dynamic responses in phosphorylation of CREB to a Pavlovian-conditioned, EtOH-paired cue.	Ethanol	315-319	cAMP responsive element binding protein 1	Mus musculus	113-117
21951632-4	2012	Interestingly, CREB phosphorylation within these regions was sensitive to manipulations of the EtOH-cue contingency-that is, the cue-induced increase of pCREB in both the PL and IL was absent following extinction.	Ethanol	95-99	cAMP responsive element binding protein 1	Mus musculus	15-19
21867753-5	2012	Here we show that mice with decreased CREB levels (CREB(alpha ) mutants) have a ~50% reduction in spontaneous seizures following pilocarpine induced status epilepticus (SE) and require more stimulation to electrically kindle.	Pilocarpine	129-140	cAMP responsive element binding protein 1	Mus musculus	38-42
21867753-5	2012	Here we show that mice with decreased CREB levels (CREB(alpha ) mutants) have a ~50% reduction in spontaneous seizures following pilocarpine induced status epilepticus (SE) and require more stimulation to electrically kindle.	Pilocarpine	129-140	cAMP responsive element binding protein 1	Mus musculus	51-55
21892690-0	2012	Inhibition of neuron-specific CREB dephosphorylation is involved in propofol and ketamine-induced neuroprotection against cerebral ischemic injuries of mice.	Ketamine	81-89	cAMP responsive element binding protein 1	Mus musculus	30-34
21892690-3	2012	The purpose of this study was to determine whether different dosages of propofol and ketamine could provide neuroprotection against permanent middle cerebral artery occlusion (MCAO)-induced ischemic injuries and the involvement of P-CREB.	Propofol	72-80	cAMP responsive element binding protein 1	Mus musculus	233-237
21892690-5	2012	We found that 50, 100 (not 25) mg/kg propofol, and 25 (not 50 and 100) mg/kg ketamine could significantly reduce the infarct volume, edema ratio and neurological deficit (n = 10 per group) as well as inhibit the decrease of P-CREB level in peri-infarct region when compared with that of MCAO + saline group (n = 6 per group).	Propofol	37-45	cAMP responsive element binding protein 1	Mus musculus	226-230
21892690-5	2012	We found that 50, 100 (not 25) mg/kg propofol, and 25 (not 50 and 100) mg/kg ketamine could significantly reduce the infarct volume, edema ratio and neurological deficit (n = 10 per group) as well as inhibit the decrease of P-CREB level in peri-infarct region when compared with that of MCAO + saline group (n = 6 per group).	Ketamine	77-85	cAMP responsive element binding protein 1	Mus musculus	226-230
21892690-6	2012	In addition, the results of double-labeled immunofluorescent staining showed that P-CREB co-localized with neuron-specific marker, NeuN, in the peri-infarct region of 50 mg/kg propofol and 25 mg/kg ketamine treated 6 h MCAO mice (n = 4 per group).	Propofol	176-184	cAMP responsive element binding protein 1	Mus musculus	84-88
21892690-6	2012	In addition, the results of double-labeled immunofluorescent staining showed that P-CREB co-localized with neuron-specific marker, NeuN, in the peri-infarct region of 50 mg/kg propofol and 25 mg/kg ketamine treated 6 h MCAO mice (n = 4 per group).	Ketamine	198-206	cAMP responsive element binding protein 1	Mus musculus	84-88
21892690-7	2012	These results suggested that inhibition of neuron-specific P-CREB dephosphorylation in the peri-infarct region is involved in high dose propofol and low dose ketamine-induced neuroprotection of 6 h MCAO mice.	Propofol	136-144	cAMP responsive element binding protein 1	Mus musculus	61-65
21892690-7	2012	These results suggested that inhibition of neuron-specific P-CREB dephosphorylation in the peri-infarct region is involved in high dose propofol and low dose ketamine-induced neuroprotection of 6 h MCAO mice.	Ketamine	158-166	cAMP responsive element binding protein 1	Mus musculus	61-65
22236576-6	2012	Activity-dependent CREB transcription induced by calcium/cAMP signals is disrupted through a mechanism involving deregulation of calcium/calcineurin-mediated dephosphorylation and activation of CRTC1.	Calcium	49-56	cAMP responsive element binding protein 1	Mus musculus	19-23
23226481-2	2012	The calcium activated protein, calcium/calmodulin-dependent protein kinase IV (CaMKIV) phosphorylates the downstream transcription factor cyclic AMP response element binding protein (CREB), which mediates nicotine responses; however the role of CaMKIV in nicotine dependence is unknown.	Nicotine	205-213	cAMP responsive element binding protein 1	Mus musculus	183-187
22236576-6	2012	Activity-dependent CREB transcription induced by calcium/cAMP signals is disrupted through a mechanism involving deregulation of calcium/calcineurin-mediated dephosphorylation and activation of CRTC1.	Cyclic AMP	57-61	cAMP responsive element binding protein 1	Mus musculus	19-23
22236576-6	2012	Activity-dependent CREB transcription induced by calcium/cAMP signals is disrupted through a mechanism involving deregulation of calcium/calcineurin-mediated dephosphorylation and activation of CRTC1.	Calcium	129-136	cAMP responsive element binding protein 1	Mus musculus	19-23
22292123-6	2012	Similar to findings in visual cortex, CREB is upregulated in dLGN after CDR and DDR.	cdr	72-75	cAMP responsive element binding protein 1	Mus musculus	38-42
23226481-2	2012	The calcium activated protein, calcium/calmodulin-dependent protein kinase IV (CaMKIV) phosphorylates the downstream transcription factor cyclic AMP response element binding protein (CREB), which mediates nicotine responses; however the role of CaMKIV in nicotine dependence is unknown.	Nicotine	255-263	cAMP responsive element binding protein 1	Mus musculus	138-181
23226481-2	2012	The calcium activated protein, calcium/calmodulin-dependent protein kinase IV (CaMKIV) phosphorylates the downstream transcription factor cyclic AMP response element binding protein (CREB), which mediates nicotine responses; however the role of CaMKIV in nicotine dependence is unknown.	Nicotine	205-213	cAMP responsive element binding protein 1	Mus musculus	138-181
23226481-2	2012	The calcium activated protein, calcium/calmodulin-dependent protein kinase IV (CaMKIV) phosphorylates the downstream transcription factor cyclic AMP response element binding protein (CREB), which mediates nicotine responses; however the role of CaMKIV in nicotine dependence is unknown.	Nicotine	255-263	cAMP responsive element binding protein 1	Mus musculus	183-187
23226481-3	2012	Given the proposed role of CaMKIV in CREB activation, we hypothesized that CaMKIV might be a crucial molecular component in the development of nicotine dependence.	Nicotine	143-151	cAMP responsive element binding protein 1	Mus musculus	37-41
22952890-11	2012	In addition, PI3-K inhibition partially abolished the inhibitory effect of resveratrol on the phosphorylation of cyclic AMP-responsive element-binding protein (CREB) and mitogen-activated protein kinases (MAPKs) cascades.	Resveratrol	75-86	cAMP responsive element binding protein 1	Mus musculus	113-158
23049845-2	2012	IRS-2 expression is stimulated by the transcription factor cAMP response element-binding protein (CREB) and we recently demonstrated that Ca(2+)/calmodulin dependent kinase 4 (CaMK4) is upstream of CREB activation in beta-cells.	Cyclic AMP	59-63	cAMP responsive element binding protein 1	Mus musculus	98-102
22952890-11	2012	In addition, PI3-K inhibition partially abolished the inhibitory effect of resveratrol on the phosphorylation of cyclic AMP-responsive element-binding protein (CREB) and mitogen-activated protein kinases (MAPKs) cascades.	Resveratrol	75-86	cAMP responsive element binding protein 1	Mus musculus	160-164
22952890-13	2012	CONCLUSION AND IMPLICATIONS: This investigation demonstrates that PI3-K/Akt activation is an important signaling in resveratrol-mediated activation of AMPK phosphorylation and SIRT1 expression, and inhibition of phosphorylation of CREB and MAPKs activation, proinflammatory mediators and cytokines production in response to LPS in RAW 264.7 cells.	Resveratrol	116-127	cAMP responsive element binding protein 1	Mus musculus	231-235
22057271-8	2011	Moreover, we identified a conserved cAMP-response element (CRE) in the murine RGS2 promoter that is critical for cAMP-response element-binding protein (CREB) binding and RGS2 promoter activation.	Cyclic AMP	36-40	cAMP responsive element binding protein 1	Mus musculus	113-150
22363816-11	2012	In addition, mTOR inhibition partially abolished the inhibitory effect of resveratrol on the phosphorylation of IkappaB-alpha, CREB, extracellular signal-regulated kinase 1/2 (ERK1/2), c-Jun N-terminal protein kinase (JNK), and p38 mitogen-activated protein kinase (p38 MAPK).	Resveratrol	74-85	cAMP responsive element binding protein 1	Mus musculus	127-131
22363816-12	2012	CONCLUSION AND IMPLICATIONS: This study indicates that resveratrol inhibited LPS-induced proinflammatory enzymes and proinflammatory cytokines via down-regulation phosphorylation of NF-kappaB, CREB and MAPKs family in a mTOR-dependent manner.	Resveratrol	55-66	cAMP responsive element binding protein 1	Mus musculus	193-197
22718613-3	2012	Mounting evidence has implicated the role of cyclic AMP (cAMP)-cAMP-dependent protein kinase (PKA)-ERK1/2-cAMP-responsive element-binding protein (CREB) cascade in numerous brain functions such as learning and memory.	Cyclic AMP	45-55	cAMP responsive element binding protein 1	Mus musculus	147-151
22718613-3	2012	Mounting evidence has implicated the role of cyclic AMP (cAMP)-cAMP-dependent protein kinase (PKA)-ERK1/2-cAMP-responsive element-binding protein (CREB) cascade in numerous brain functions such as learning and memory.	Cyclic AMP	57-61	cAMP responsive element binding protein 1	Mus musculus	147-151
22718613-3	2012	Mounting evidence has implicated the role of cyclic AMP (cAMP)-cAMP-dependent protein kinase (PKA)-ERK1/2-cAMP-responsive element-binding protein (CREB) cascade in numerous brain functions such as learning and memory.	Cyclic AMP	63-67	cAMP responsive element binding protein 1	Mus musculus	147-151
22718613-7	2012	Consistent with the current hypothesis, the Ca2+-stimulated cAMP production through AC1 and AC8 is required for the activity-dependent activation of the ERK1/2-CREB cascade.	Cyclic AMP	60-64	cAMP responsive element binding protein 1	Mus musculus	160-164
22057271-8	2011	Moreover, we identified a conserved cAMP-response element (CRE) in the murine RGS2 promoter that is critical for cAMP-response element-binding protein (CREB) binding and RGS2 promoter activation.	Cyclic AMP	36-40	cAMP responsive element binding protein 1	Mus musculus	152-156
21302281-5	2011	In contrast, CREB Ser(133) was transiently dephosphorylated upon osmotic shrinkage.	Serine	18-21	cAMP responsive element binding protein 1	Mus musculus	13-17
22078933-5	2011	We identify Lys136 is a substrate for SirT1-dependent deacetylation that affects Creb activity by preventing its cAMP-dependent phosphorylation, leading to reduced expression of glucogenic genes and promoting hepatic lipid accumulation and secretion.	Cyclic AMP	113-117	cAMP responsive element binding protein 1	Mus musculus	81-85
22078933-6	2011	Expression of constitutively acetylated Creb (K136Q) in SirBACO mice mimics Creb activation and abolishes the dyslipidemic and insulin-sensitizing effects of SirT1 gain of function.	k136q	46-51	cAMP responsive element binding protein 1	Mus musculus	40-44
22078933-6	2011	Expression of constitutively acetylated Creb (K136Q) in SirBACO mice mimics Creb activation and abolishes the dyslipidemic and insulin-sensitizing effects of SirT1 gain of function.	k136q	46-51	cAMP responsive element binding protein 1	Mus musculus	76-80
22078933-7	2011	We propose that SirT1-dependent Creb deacetylation regulates the balance between glucose and lipid metabolism, integrating fasting signals.	Glucose	81-88	cAMP responsive element binding protein 1	Mus musculus	32-36
22003853-8	2011	The protein network analysis suggests involvement of CREB and caspase-3 pathways in the DHA-dependent modulation of synaptic proteome.	Docosahexaenoic Acids	88-91	cAMP responsive element binding protein 1	Mus musculus	53-57
21813366-6	2011	BPA stimulated a rapid (15-min) phosphorylation of the transcription factor cAMP response element binding protein (CREB) and the cell cycle regulator retinoblastoma protein (Rb).	bisphenol A	0-3	cAMP responsive element binding protein 1	Mus musculus	115-119
21800176-5	2011	In addition, the effects of honokiol on the activation of PI3K (phosphoinositide 3-kinase) and CREB (cAMP-responsive element-binding protein) were examined in MC3T3-E1 cells.	honokiol	28-36	cAMP responsive element binding protein 1	Mus musculus	101-140
21800176-8	2011	Honokiol also induced the activation of PI3K and CREB inhibited by antimycin A, which demonstrates that honokiol utilizes the PI3K and CREB pathway to augment metabolic activity inhibited by antimycin A.	honokiol	0-8	cAMP responsive element binding protein 1	Mus musculus	49-53
21800176-8	2011	Honokiol also induced the activation of PI3K and CREB inhibited by antimycin A, which demonstrates that honokiol utilizes the PI3K and CREB pathway to augment metabolic activity inhibited by antimycin A.	honokiol	0-8	cAMP responsive element binding protein 1	Mus musculus	135-139
21800176-8	2011	Honokiol also induced the activation of PI3K and CREB inhibited by antimycin A, which demonstrates that honokiol utilizes the PI3K and CREB pathway to augment metabolic activity inhibited by antimycin A.	Antimycin A	67-78	cAMP responsive element binding protein 1	Mus musculus	49-53
21800176-8	2011	Honokiol also induced the activation of PI3K and CREB inhibited by antimycin A, which demonstrates that honokiol utilizes the PI3K and CREB pathway to augment metabolic activity inhibited by antimycin A.	Antimycin A	67-78	cAMP responsive element binding protein 1	Mus musculus	135-139
21800176-8	2011	Honokiol also induced the activation of PI3K and CREB inhibited by antimycin A, which demonstrates that honokiol utilizes the PI3K and CREB pathway to augment metabolic activity inhibited by antimycin A.	honokiol	104-112	cAMP responsive element binding protein 1	Mus musculus	49-53
21800176-8	2011	Honokiol also induced the activation of PI3K and CREB inhibited by antimycin A, which demonstrates that honokiol utilizes the PI3K and CREB pathway to augment metabolic activity inhibited by antimycin A.	honokiol	104-112	cAMP responsive element binding protein 1	Mus musculus	135-139
21800176-8	2011	Honokiol also induced the activation of PI3K and CREB inhibited by antimycin A, which demonstrates that honokiol utilizes the PI3K and CREB pathway to augment metabolic activity inhibited by antimycin A.	Antimycin A	191-202	cAMP responsive element binding protein 1	Mus musculus	135-139
22162970-4	2011	Basally, in the Str of PCOC treated mice there were significantly higher levels of (1) CREB and Ser133 P-CREB (2) Thr34 P-DARPP-32 and (3) GluA1 and Ser 845 P-GluA1 when compared to prenatal saline (PSAL) treated mice.	Serine	96-99	cAMP responsive element binding protein 1	Mus musculus	105-109
22162970-10	2011	In sharp contrast to the observations in the Str, in the NAc, acute administration of cocaine or D1 agonist significantly increased P-CREB and P-ERK2 in PSAL mice, a response that was not evident in PCOC mice.	Cocaine	86-93	cAMP responsive element binding protein 1	Mus musculus	134-138
21660443-0	2011	Aromatic-turmerone inhibits alpha-MSH and IBMX-induced melanogenesis by inactivating CREB and MITF signaling pathways.	ar-turmerone	0-18	cAMP responsive element binding protein 1	Mus musculus	85-89
21813366-6	2011	BPA stimulated a rapid (15-min) phosphorylation of the transcription factor cAMP response element binding protein (CREB) and the cell cycle regulator retinoblastoma protein (Rb).	bisphenol A	0-3	cAMP responsive element binding protein 1	Mus musculus	76-113
21723942-7	2011	In this study, NTN activation of GFRalpha2a and GFRalpha2c but not GFRalpha2b induced biphasic ERK1/2 activation and phosphorylation of the major cAMP target CREB.	Cyclic AMP	146-150	cAMP responsive element binding protein 1	Mus musculus	158-162
21302281-6	2011	The ERK1/2 effector ribosomal S kinase (RSK) and the ERK1/2- and p38 MAPK effector mitogen- stress-activated protein kinase 1 (MSK1) both phosphorylate CREB at Ser(133) .	Serine	160-163	cAMP responsive element binding protein 1	Mus musculus	152-156
21990347-5	2011	At the cellular level, we showed that intracellular OPN modulated the capacity of the beta2-adrenergic receptor to generate cAMP with a corresponding modulation of cAMP-response element binding (CREB) phosphorylation and associated transcriptional events inside the cell.	Cyclic AMP	124-128	cAMP responsive element binding protein 1	Mus musculus	195-199
21907331-6	2011	Caffeine treatment stimulated PKA activity, increased phospho-CREB levels, and decreased phospho-JNK and phospho-ERK expression in the striatum of APPswe mice, all of which are thought to be beneficial changes for brain function.	Caffeine	0-8	cAMP responsive element binding protein 1	Mus musculus	62-66
21782812-5	2011	PKA activation was measured by the phosphorylation of cAMP-response element binding protein (CREB) on serine 133 (S133).	Serine	102-108	cAMP responsive element binding protein 1	Mus musculus	54-91
21782812-5	2011	PKA activation was measured by the phosphorylation of cAMP-response element binding protein (CREB) on serine 133 (S133).	Serine	102-108	cAMP responsive element binding protein 1	Mus musculus	93-97
21782812-8	2011	PKA inhibitor, H-89, reduced CREB (S133) phosphorylation and mBAFF expression in control and LPS-stimulated macrophages.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	15-19	cAMP responsive element binding protein 1	Mus musculus	29-33
21896570-8	2011	Sesamin-mediated phosphorylation of CREB and induction of MITF and tyrosinase expression were also inhibited by H-89.	sesamin	0-7	cAMP responsive element binding protein 1	Mus musculus	36-40
21808064-7	2011	We demonstrate that nuclear JAK2 regulates the amount of active transcription factor CREB (cAMP response element-binding protein) through tyrosine phosphorylation and prevention of proteasomal degradation, which in turn leads to transcriptional activation of the rate-limiting steroidogenic Star gene.	Tyrosine	138-146	cAMP responsive element binding protein 1	Mus musculus	85-89
21896570-5	2011	Sesamin could activate cAMP response element (CRE) binding protein (CREB), but it had no effect on the phosphorylation of p38 mitogen-activated protein kinase (MAPK) or Akt.	sesamin	0-7	cAMP responsive element binding protein 1	Mus musculus	68-72
21808064-7	2011	We demonstrate that nuclear JAK2 regulates the amount of active transcription factor CREB (cAMP response element-binding protein) through tyrosine phosphorylation and prevention of proteasomal degradation, which in turn leads to transcriptional activation of the rate-limiting steroidogenic Star gene.	Tyrosine	138-146	cAMP responsive element binding protein 1	Mus musculus	91-128
21859486-4	2011	RESULTS: Here we show that exposure of mice to a mixture of odorants induced a significant increase in the levels of the transcription factor CREB phosphorylated at Ser-133 in the nuclei of both olfactory sensory neurons and sustentacular cells.	Serine	165-168	cAMP responsive element binding protein 1	Mus musculus	142-146
21569106-1	2011	Microphthalmia-associated transcription factor (MITF) is inducible in response to cAMP through the cAMP-responsive element-binding protein (CREB) and plays a pivotal role in the melanocyte-specific expression of tyrosinase or tyrosinase-related proteins (TRPs) for melanin biosynthesis.	Cyclic AMP	82-86	cAMP responsive element binding protein 1	Mus musculus	99-138
21569106-1	2011	Microphthalmia-associated transcription factor (MITF) is inducible in response to cAMP through the cAMP-responsive element-binding protein (CREB) and plays a pivotal role in the melanocyte-specific expression of tyrosinase or tyrosinase-related proteins (TRPs) for melanin biosynthesis.	Cyclic AMP	82-86	cAMP responsive element binding protein 1	Mus musculus	140-144
21569106-1	2011	Microphthalmia-associated transcription factor (MITF) is inducible in response to cAMP through the cAMP-responsive element-binding protein (CREB) and plays a pivotal role in the melanocyte-specific expression of tyrosinase or tyrosinase-related proteins (TRPs) for melanin biosynthesis.	Melanins	265-272	cAMP responsive element binding protein 1	Mus musculus	99-138
21569106-1	2011	Microphthalmia-associated transcription factor (MITF) is inducible in response to cAMP through the cAMP-responsive element-binding protein (CREB) and plays a pivotal role in the melanocyte-specific expression of tyrosinase or tyrosinase-related proteins (TRPs) for melanin biosynthesis.	Melanins	265-272	cAMP responsive element binding protein 1	Mus musculus	140-144
21569106-5	2011	Moreover, manassantin A suppressed MITF induction through IBMX-activated CREB pathway, directly inhibiting the Ser-133 phosphorylation of CREB.	Serine	111-114	cAMP responsive element binding protein 1	Mus musculus	73-77
21569106-5	2011	Moreover, manassantin A suppressed MITF induction through IBMX-activated CREB pathway, directly inhibiting the Ser-133 phosphorylation of CREB.	Serine	111-114	cAMP responsive element binding protein 1	Mus musculus	138-142
21621525-8	2011	Since phosphoinositide 3-kinase (PI3K) and cAMP-response element-binding protein (CREB) signaling is known to be pro-survival, we determined whether PI3K and CREB activation is associated with the cytoprotective effects of glabridin in the MC3T3-E1 cells.	glabridin	223-232	cAMP responsive element binding protein 1	Mus musculus	158-162
21621525-9	2011	Glabridin restored antimycin A-induced inactivation of PI3K and CREB, suggesting that PI3K and CREB-dependent pathways may be involved in glabridin-induced cytoprotective responses.	glabridin	0-9	cAMP responsive element binding protein 1	Mus musculus	64-68
21621525-9	2011	Glabridin restored antimycin A-induced inactivation of PI3K and CREB, suggesting that PI3K and CREB-dependent pathways may be involved in glabridin-induced cytoprotective responses.	glabridin	0-9	cAMP responsive element binding protein 1	Mus musculus	95-99
21621525-9	2011	Glabridin restored antimycin A-induced inactivation of PI3K and CREB, suggesting that PI3K and CREB-dependent pathways may be involved in glabridin-induced cytoprotective responses.	Antimycin A	19-30	cAMP responsive element binding protein 1	Mus musculus	64-68
21621525-9	2011	Glabridin restored antimycin A-induced inactivation of PI3K and CREB, suggesting that PI3K and CREB-dependent pathways may be involved in glabridin-induced cytoprotective responses.	Antimycin A	19-30	cAMP responsive element binding protein 1	Mus musculus	95-99
21621525-9	2011	Glabridin restored antimycin A-induced inactivation of PI3K and CREB, suggesting that PI3K and CREB-dependent pathways may be involved in glabridin-induced cytoprotective responses.	glabridin	138-147	cAMP responsive element binding protein 1	Mus musculus	64-68
21621525-9	2011	Glabridin restored antimycin A-induced inactivation of PI3K and CREB, suggesting that PI3K and CREB-dependent pathways may be involved in glabridin-induced cytoprotective responses.	glabridin	138-147	cAMP responsive element binding protein 1	Mus musculus	95-99
21910056-1	2011	Intracellular cAMP stimulates microphthalmia-associated transcription factor (MITF) induction in melanocytes through cAMP-responsive element binding protein (CREB), which plays a pivotal role in the gene expression of tyrosinase for melanin biosynthesis.	Cyclic AMP	14-18	cAMP responsive element binding protein 1	Mus musculus	117-156
21803292-3	2011	In one model, the main CBP interaction with the glucagon-responsive factor CREB is not limiting for liver gluconeogenesis, whereas a second model posits that Ser436 in the CH1 (TAZ1) domain of CBP is required for insulin and the antidiabetic drug metformin to inhibit CREB-mediated liver gluconeogenesis.	Glucagon	48-56	cAMP responsive element binding protein 1	Mus musculus	75-79
21722651-11	2011	Furthermore, treatment with NAC blocked the transcriptional activation of CREB, and the expression of dominant-negative mutants of CREB inhibited adipocyte differentiation.	Acetylcysteine	28-31	cAMP responsive element binding protein 1	Mus musculus	74-78
21722651-12	2011	SIGNIFICANCE: The findings suggest that the increase in the intracellular ROS level via Nox4 mediates adipocyte differentiation through CREB in MSC.	Reactive Oxygen Species	74-77	cAMP responsive element binding protein 1	Mus musculus	136-140
21910056-1	2011	Intracellular cAMP stimulates microphthalmia-associated transcription factor (MITF) induction in melanocytes through cAMP-responsive element binding protein (CREB), which plays a pivotal role in the gene expression of tyrosinase for melanin biosynthesis.	Melanins	233-240	cAMP responsive element binding protein 1	Mus musculus	117-156
21910056-1	2011	Intracellular cAMP stimulates microphthalmia-associated transcription factor (MITF) induction in melanocytes through cAMP-responsive element binding protein (CREB), which plays a pivotal role in the gene expression of tyrosinase for melanin biosynthesis.	Cyclic AMP	14-18	cAMP responsive element binding protein 1	Mus musculus	158-162
21910056-1	2011	Intracellular cAMP stimulates microphthalmia-associated transcription factor (MITF) induction in melanocytes through cAMP-responsive element binding protein (CREB), which plays a pivotal role in the gene expression of tyrosinase for melanin biosynthesis.	Melanins	233-240	cAMP responsive element binding protein 1	Mus musculus	158-162
21565246-5	2011	Kaempferol also induced the activation of PI3K (phosphoinositide 3-kinase), Akt (protein kinase B), and CREB (cAMP-response element-binding protein) inhibited by AMA, which result demonstrates that kaempferol utilizes the PI3K/Akt/CREB pathway to augment metabolic activity inhibited by AMA.	kaempferol	198-208	cAMP responsive element binding protein 1	Mus musculus	231-235
21910056-4	2011	As to the molecular basis of hypopigmenting action, saucerneol D inhibited alpha-MSH-induced phosphorylation of CREB in the cells, and sequentially suppressed MITF induction.	saucerneol D	52-64	cAMP responsive element binding protein 1	Mus musculus	112-116
21565246-5	2011	Kaempferol also induced the activation of PI3K (phosphoinositide 3-kinase), Akt (protein kinase B), and CREB (cAMP-response element-binding protein) inhibited by AMA, which result demonstrates that kaempferol utilizes the PI3K/Akt/CREB pathway to augment metabolic activity inhibited by AMA.	kaempferol	0-10	cAMP responsive element binding protein 1	Mus musculus	104-108
21565246-5	2011	Kaempferol also induced the activation of PI3K (phosphoinositide 3-kinase), Akt (protein kinase B), and CREB (cAMP-response element-binding protein) inhibited by AMA, which result demonstrates that kaempferol utilizes the PI3K/Akt/CREB pathway to augment metabolic activity inhibited by AMA.	kaempferol	0-10	cAMP responsive element binding protein 1	Mus musculus	110-147
21565246-5	2011	Kaempferol also induced the activation of PI3K (phosphoinositide 3-kinase), Akt (protein kinase B), and CREB (cAMP-response element-binding protein) inhibited by AMA, which result demonstrates that kaempferol utilizes the PI3K/Akt/CREB pathway to augment metabolic activity inhibited by AMA.	kaempferol	0-10	cAMP responsive element binding protein 1	Mus musculus	231-235
21565246-5	2011	Kaempferol also induced the activation of PI3K (phosphoinositide 3-kinase), Akt (protein kinase B), and CREB (cAMP-response element-binding protein) inhibited by AMA, which result demonstrates that kaempferol utilizes the PI3K/Akt/CREB pathway to augment metabolic activity inhibited by AMA.	kaempferol	198-208	cAMP responsive element binding protein 1	Mus musculus	110-147
21402151-7	2011	Phosphorylation of TRPC7 significantly suppressed carbachol-induced calcium influx and CREB phosphorylation.	Carbachol	50-59	cAMP responsive element binding protein 1	Mus musculus	87-91
21576335-8	2011	Because CREB and GSK-3 activity appeared to be important for ET-induced ANTXR expression, the impact of GSK-3 on ET-induced CREB activity was examined in RAW 264.7 cells possessing a CRE-luciferase reporter.	et	113-115	cAMP responsive element binding protein 1	Mus musculus	124-128
21644508-2	2011	Evidence for increased cAMP-mediated signaling in CF included increased phosphorylation of the cAMP response element binding protein (CREB) and elevated beta-arrestin-2 (betaarr2) expression.	Cyclic AMP	23-27	cAMP responsive element binding protein 1	Mus musculus	95-132
21644508-2	2011	Evidence for increased cAMP-mediated signaling in CF included increased phosphorylation of the cAMP response element binding protein (CREB) and elevated beta-arrestin-2 (betaarr2) expression.	Cyclic AMP	23-27	cAMP responsive element binding protein 1	Mus musculus	134-138
21668646-2	2011	In this study, we identified a novel suppression mechanism, operating in the early phase of adipogenesis, that increased the production of anti-adipogenic PGF(2alpha) and PGE(2) by enhancing cyclooxygenase (COX) 2 expression through the PGF(2alpha) -activated FP receptor/extracellular-signal-regulated kinase (ERK)/cyclic AMP response element binding protein (CREB) cascade.	Prostaglandins F	155-158	cAMP responsive element binding protein 1	Mus musculus	361-365
21668646-2	2011	In this study, we identified a novel suppression mechanism, operating in the early phase of adipogenesis, that increased the production of anti-adipogenic PGF(2alpha) and PGE(2) by enhancing cyclooxygenase (COX) 2 expression through the PGF(2alpha) -activated FP receptor/extracellular-signal-regulated kinase (ERK)/cyclic AMP response element binding protein (CREB) cascade.	Prostaglandins E	171-174	cAMP responsive element binding protein 1	Mus musculus	361-365
21668646-2	2011	In this study, we identified a novel suppression mechanism, operating in the early phase of adipogenesis, that increased the production of anti-adipogenic PGF(2alpha) and PGE(2) by enhancing cyclooxygenase (COX) 2 expression through the PGF(2alpha) -activated FP receptor/extracellular-signal-regulated kinase (ERK)/cyclic AMP response element binding protein (CREB) cascade.	Prostaglandins F	237-240	cAMP responsive element binding protein 1	Mus musculus	361-365
21668646-2	2011	In this study, we identified a novel suppression mechanism, operating in the early phase of adipogenesis, that increased the production of anti-adipogenic PGF(2alpha) and PGE(2) by enhancing cyclooxygenase (COX) 2 expression through the PGF(2alpha) -activated FP receptor/extracellular-signal-regulated kinase (ERK)/cyclic AMP response element binding protein (CREB) cascade.	Cyclic AMP	316-326	cAMP responsive element binding protein 1	Mus musculus	361-365
21668646-8	2011	Furthermore, promoter-luciferase and chromatin immunoprecipitation assays demonstrated that PGF(2alpha) -derived COX-2 expression was activated through binding of CREB to the promoter region of the COX-2 gene in 3T3-L1 cells.	Prostaglandins F	92-95	cAMP responsive element binding protein 1	Mus musculus	163-167
21668646-9	2011	These results indicate that PGF(2alpha) suppresses the progression of the early phase of adipogenesis by enhancing the binding of CREB to the COX-2 promoter via FP receptor activated MEK/ERK cascade.	Prostaglandins F	28-31	cAMP responsive element binding protein 1	Mus musculus	130-134
21620566-7	2011	Likewise, alpha,beta-amyrin prevented the activation of the transcriptional factors: nuclear factor kappaB (NF-kappaB) and cyclic adenosine monophosphate response element binding (CREB) and the expression of cyclooxygenase 2 in mice footpads and spinal cords.	alpha,beta-amyrin	10-27	cAMP responsive element binding protein 1	Mus musculus	180-184
21620566-7	2011	Likewise, alpha,beta-amyrin prevented the activation of the transcriptional factors: nuclear factor kappaB (NF-kappaB) and cyclic adenosine monophosphate response element binding (CREB) and the expression of cyclooxygenase 2 in mice footpads and spinal cords.	Cyclic AMP	123-153	cAMP responsive element binding protein 1	Mus musculus	180-184
21620566-8	2011	The present results demonstrated that alpha,beta-amyrin exhibits long-lasting antinociceptive and anti-inflammatory properties in 2 models of persistent nociception via activation of cannabinoid receptors and by inhibiting the production of cytokines and expression of NF-kappaB, CREB and cyclooxygenase 2.	alpha,beta-amyrin	38-55	cAMP responsive element binding protein 1	Mus musculus	280-284
21632535-9	2011	We conclude that PDE3A regulates VSMC growth via two complementary pathways, i.e. PKA-catalyzed inhibitory phosphorylation of Raf-1 with resulting inhibition of MAPK signaling and PKA/CREB-mediated induction of p21, leading to G0/G1 cell cycle arrest, as well as by increased accumulation of p53, which induces MKP-1, p21, and WIP1, leading to inhibition of G1 to S cell cycle progression.	vsmc	33-37	cAMP responsive element binding protein 1	Mus musculus	184-188
21607831-1	2011	Cyclic AMP (cAMP) response element-binding protein (CREB) is involved in memory, learning, and synaptic transmission.	Cyclic AMP	0-10	cAMP responsive element binding protein 1	Mus musculus	52-56
21458469-2	2011	The effects of cAMP are mediated through downstream effectors such as protein kinase A (PKA), Ca(2+) and cAMP-response element binding protein (CREB).	Cyclic AMP	15-19	cAMP responsive element binding protein 1	Mus musculus	105-142
21607831-1	2011	Cyclic AMP (cAMP) response element-binding protein (CREB) is involved in memory, learning, and synaptic transmission.	Cyclic AMP	12-16	cAMP responsive element binding protein 1	Mus musculus	52-56
21458469-2	2011	The effects of cAMP are mediated through downstream effectors such as protein kinase A (PKA), Ca(2+) and cAMP-response element binding protein (CREB).	Cyclic AMP	15-19	cAMP responsive element binding protein 1	Mus musculus	144-148
21232579-0	2011	Alterations in BDNF and phospho-CREB levels following chronic oral nicotine treatment and its withdrawal in dopaminergic brain areas of mice.	Nicotine	67-75	cAMP responsive element binding protein 1	Mus musculus	32-36
19577336-6	2011	Dietary vitamin E alleviated Prx II deficiency-related deficits, including mitochondrial decay and CREB signaling, resulting in restoration of the abrupt cognitive decline in aged Prx II(-/-) mice.	Vitamin E	8-17	cAMP responsive element binding protein 1	Mus musculus	99-103
21398611-6	2011	Mal-deficient cells also fail to express the CREB-responsive genes IL-10 and cyclooxygenase 2 in response to Pam(2)Cys-Ser-(Lys)4 and LPS.	(2)cys	112-118	cAMP responsive element binding protein 1	Mus musculus	45-49
21398611-6	2011	Mal-deficient cells also fail to express the CREB-responsive genes IL-10 and cyclooxygenase 2 in response to Pam(2)Cys-Ser-(Lys)4 and LPS.	Serine	119-122	cAMP responsive element binding protein 1	Mus musculus	45-49
21398611-8	2011	We also demonstrate the importance of p38 MAPK in this pathway with the p38 inhibitor SB203580 abolishing activation of CREB in murine macrophages.	SB 203580	86-94	cAMP responsive element binding protein 1	Mus musculus	120-124
21319221-8	2011	We identify that two mechanisms of GSK3beta inhibition are to stimulate cAMP response element binding (CREB) and decrease Notch1 signaling, which positively and negatively regulate OL differentiation and myelination, respectively.	Cyclic AMP	72-76	cAMP responsive element binding protein 1	Mus musculus	103-107
20949368-7	2011	CREB was implicated as shown by EMSA analysis and decoy-oligonucleotides scavenging CREB in RAW264.7 MPhis, which blocked ARG II expression.	decoy-oligonucleotides	50-72	cAMP responsive element binding protein 1	Mus musculus	0-4
20949368-7	2011	CREB was implicated as shown by EMSA analysis and decoy-oligonucleotides scavenging CREB in RAW264.7 MPhis, which blocked ARG II expression.	decoy-oligonucleotides	50-72	cAMP responsive element binding protein 1	Mus musculus	84-88
20949368-7	2011	CREB was implicated as shown by EMSA analysis and decoy-oligonucleotides scavenging CREB in RAW264.7 MPhis, which blocked ARG II expression.	Arginine	122-125	cAMP responsive element binding protein 1	Mus musculus	0-4
20949368-7	2011	CREB was implicated as shown by EMSA analysis and decoy-oligonucleotides scavenging CREB in RAW264.7 MPhis, which blocked ARG II expression.	Arginine	122-125	cAMP responsive element binding protein 1	Mus musculus	84-88
21301804-2	2011	Cyclic AMP response element-binding protein (CREB) stimulates beta cell Irs2 expression and is a major calcium/calmodulin-dependent kinase (CaMK)(IV) target in neurons.	Cyclic AMP	0-10	cAMP responsive element binding protein 1	Mus musculus	45-49
21301804-3	2011	We therefore hypothesised that CaMK(IV) mediates glucose-induced Irs2 expression in beta cells via CREB activation.	Glucose	49-56	cAMP responsive element binding protein 1	Mus musculus	99-103
21301804-7	2011	RESULTS: Increasing the glucose concentration from 2.5 to 25 mmol/l stimulated CREB phosphorylation on serine 133 and specifically stimulated Irs2 but not Irs1 expression.	Glucose	24-31	cAMP responsive element binding protein 1	Mus musculus	79-83
21301804-7	2011	RESULTS: Increasing the glucose concentration from 2.5 to 25 mmol/l stimulated CREB phosphorylation on serine 133 and specifically stimulated Irs2 but not Irs1 expression.	Serine	103-109	cAMP responsive element binding protein 1	Mus musculus	79-83
21301804-11	2011	Finally, overproduction of a dominant negative form of CREB completely suppressed glucose and CaMK(IV) stimulation of Irs2 expression.	Glucose	82-89	cAMP responsive element binding protein 1	Mus musculus	55-59
21499833-7	2011	Interestingly, the LPA-stimulated tau phosphorylation and neurite retraction were markedly prevented by the administration of H89, an inhibitor of both cyclic-AMP dependent protein kinase (PKA) and cyclic-AMP response element-binding protein (CREB).	lysophosphatidic acid	19-22	cAMP responsive element binding protein 1	Mus musculus	198-241
21499833-7	2011	Interestingly, the LPA-stimulated tau phosphorylation and neurite retraction were markedly prevented by the administration of H89, an inhibitor of both cyclic-AMP dependent protein kinase (PKA) and cyclic-AMP response element-binding protein (CREB).	lysophosphatidic acid	19-22	cAMP responsive element binding protein 1	Mus musculus	243-247
21333723-8	2011	TN-2 also markedly increased BNDF expression and activated the transcription factor CREB in the hippocampi of scopolamine-treated mice.	Scopolamine	110-121	cAMP responsive element binding protein 1	Mus musculus	84-88
21220406-11	2011	These results support the hypothesis that DHT can activate a pathway involving the sequential activation of MEK, ERK1/2, and CREB through the EGFR/IGF1R in an epididymal cell line.	Dihydrotestosterone	42-45	cAMP responsive element binding protein 1	Mus musculus	125-129
21232579-10	2011	In conclusion, the current results suggest the involvement of BDNF- and CREB-related neuronal processes in nicotine-induced neurochemical, behavioural, and neuroplastic changes in dopaminergic neurocircuits.	Nicotine	107-115	cAMP responsive element binding protein 1	Mus musculus	72-76
20809180-8	2011	Although the effect of the saturated FA was similar, the mechanism involved in each case seem to be distinct, as palmitic acid increased EGR-1 and CREB binding activity and stearic acid increased mRNA poly(A) tail.	Palmitic Acid	113-126	cAMP responsive element binding protein 1	Mus musculus	147-151
21408140-1	2011	The cAMP response element binding protein 1 (Creb1) transcription factor regulates cellular gene expression in response to elevated levels of intracellular cAMP.	Cyclic AMP	4-8	cAMP responsive element binding protein 1	Mus musculus	45-50
21289174-1	2011	Rubinstein-Taybi syndrome (RSTS) is an inheritable disease associated with mutations in the gene encoding the CREB (cAMP response element-binding protein)-binding protein (CBP) and characterized by growth impairment, learning disabilities, and distinctive facial and skeletal features.	Cyclic AMP	116-120	cAMP responsive element binding protein 1	Mus musculus	110-114
21073925-14	2011	The expression of CREB phosphorylation (Ser-133) was significantly higher in naive nNOS KO mice than in WT counterparts, and pharmacological modulators of NO had significant effects on levels of CREB phosphorylation and expression.	Serine	40-43	cAMP responsive element binding protein 1	Mus musculus	18-22
20888885-0	2011	The inhibitory effect of raloxifene on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells is mediated through a ROS/p38 MAPK/CREB pathway to the up-regulation of heme oxygenase-1 independent of estrogen receptor.	Raloxifene Hydrochloride	25-35	cAMP responsive element binding protein 1	Mus musculus	143-147
20803555-8	2011	The CB2-induced stimulation of CREB and cyclin D1 is inhibitable by pertussis toxin, the MEK-Erk1/2 inhibitors PD098059 and U0126, and Mapkapk2 siRNA.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	111-119	cAMP responsive element binding protein 1	Mus musculus	31-35
20888885-10	2011	Therefore, identification of ROS-p38 MAPK-CREB-linked cascade as cellular relays in raloxifene-mediated HO-1 expression defines the signaling events that could participate in raloxifene-mediated anti-inflammatory response.	Reactive Oxygen Species	29-32	cAMP responsive element binding protein 1	Mus musculus	42-46
20888885-10	2011	Therefore, identification of ROS-p38 MAPK-CREB-linked cascade as cellular relays in raloxifene-mediated HO-1 expression defines the signaling events that could participate in raloxifene-mediated anti-inflammatory response.	Raloxifene Hydrochloride	84-94	cAMP responsive element binding protein 1	Mus musculus	42-46
20888885-10	2011	Therefore, identification of ROS-p38 MAPK-CREB-linked cascade as cellular relays in raloxifene-mediated HO-1 expression defines the signaling events that could participate in raloxifene-mediated anti-inflammatory response.	Raloxifene Hydrochloride	175-185	cAMP responsive element binding protein 1	Mus musculus	42-46
20888885-0	2011	The inhibitory effect of raloxifene on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells is mediated through a ROS/p38 MAPK/CREB pathway to the up-regulation of heme oxygenase-1 independent of estrogen receptor.	Nitric Oxide	66-78	cAMP responsive element binding protein 1	Mus musculus	143-147
20888885-8	2011	Furthermore, the ROS-p38 MAPK cascade targeted the transcription factor cAMP-responsive element-binding protein (CREB).	Reactive Oxygen Species	17-20	cAMP responsive element binding protein 1	Mus musculus	72-111
20888885-8	2011	Furthermore, the ROS-p38 MAPK cascade targeted the transcription factor cAMP-responsive element-binding protein (CREB).	Reactive Oxygen Species	17-20	cAMP responsive element binding protein 1	Mus musculus	113-117
20803555-8	2011	The CB2-induced stimulation of CREB and cyclin D1 is inhibitable by pertussis toxin, the MEK-Erk1/2 inhibitors PD098059 and U0126, and Mapkapk2 siRNA.	U 0126	124-129	cAMP responsive element binding protein 1	Mus musculus	31-35
21701076-2	2011	We investigated whether the transcription factor cAMP response element (CRE)-binding protein (CREB) is involved in the regulation of cell proliferation of neural stem cells (NSCs) isolated from the SVZ of adult mice.	Cyclic AMP	49-53	cAMP responsive element binding protein 1	Mus musculus	94-98
21199900-9	2011	To our knowledge, our results are the first to show that CREB activation is involved in ICAM-1 upregulation and suggest that cPLA(2)alpha activated by NADPH oxidase is required for sequential phosphorylation of NF-kappaB by an undefined kinase and CREB activation by PGE(2)-mediated protein kinase A.	Prostaglandins E	267-270	cAMP responsive element binding protein 1	Mus musculus	57-61
21224411-2	2011	Chromatin-modifying enzymes, such as the histone acetyltransferase (HAT) CREB (cyclic-AMP response element binding) binding protein (CBP), are pivotal for the transcriptional regulation required for long-term memory.	Cyclic AMP	79-89	cAMP responsive element binding protein 1	Mus musculus	73-77
21597199-6	2011	Therefore, we suggest that CEFV induces downregulation of melanogenesis through decreased CREB phosphorylation and ERK activation.	cefv	27-31	cAMP responsive element binding protein 1	Mus musculus	90-94
20946259-7	2011	These data show that non-lethal concentrations of ET and ACT impose a prolonged block on the proliferation of J774 cells by impairment of the progression from G(1) /G(0) to S phase in a process involving cAMP-mediated increases in phospho-CREB and p27(Kip1) and reductions in phospho-ERK 1/2 and Cyclin D1.	Cyclic AMP	204-208	cAMP responsive element binding protein 1	Mus musculus	239-243
21044639-2	2011	Increased neurotransmitter (e.g. acetylcholine and histamine) release associated with this pharmacology may lead to activation of postsynaptic signaling pathways relevant to cognition and neuroprotection, such as increased phosphorylation of CREB, a transcription factor germane to cognitive function, and the inhibitory residue (Ser-9) of GSK3beta, a primary tau kinase associated with AD pathology.	Acetylcholine	33-46	cAMP responsive element binding protein 1	Mus musculus	242-246
21044639-2	2011	Increased neurotransmitter (e.g. acetylcholine and histamine) release associated with this pharmacology may lead to activation of postsynaptic signaling pathways relevant to cognition and neuroprotection, such as increased phosphorylation of CREB, a transcription factor germane to cognitive function, and the inhibitory residue (Ser-9) of GSK3beta, a primary tau kinase associated with AD pathology.	Histamine	51-60	cAMP responsive element binding protein 1	Mus musculus	242-246
21044639-2	2011	Increased neurotransmitter (e.g. acetylcholine and histamine) release associated with this pharmacology may lead to activation of postsynaptic signaling pathways relevant to cognition and neuroprotection, such as increased phosphorylation of CREB, a transcription factor germane to cognitive function, and the inhibitory residue (Ser-9) of GSK3beta, a primary tau kinase associated with AD pathology.	Serine	330-333	cAMP responsive element binding protein 1	Mus musculus	242-246
21044639-6	2011	Continuous (2-wk) s.c. infusion of ABT-239 (0.7 mg/kg/day) normalized reduced cortical CREB and hippocampal S(9)-GSK3beta phosphorylation observed in Tg2576 (APP) AD-transgenic mice.	benzonitrile, 4-(2-(2-((2r)-2-methyl-1-pyrrolidinyl)ethyl)-5-benzofuranyl)-	35-42	cAMP responsive element binding protein 1	Mus musculus	87-91
21187319-3	2011	Cell-specific gene deletion experiments and intracerebroventricular leptin infusions reveal that serotonin signals in arcuate nuclei of the hypothalamus through the Htr1a receptor to favor food intake and that this serotonin function requires the expression of Creb, which regulates the expression of several genes affecting appetite.	Serotonin	97-106	cAMP responsive element binding protein 1	Mus musculus	261-265
21220944-6	2011	As with cAMP-responsive CREB targets, we propose that the signal-responsive recruitment of CBP and p300 does not necessarily indicate a requirement for these coactivators at a locus.	Cyclic AMP	8-12	cAMP responsive element binding protein 1	Mus musculus	24-28
21220102-2	2011	We found that salt-inducible kinase 2 (SIK2) was abundantly expressed in neurons and suppressed CREB-mediated gene expression after oxygen-glucose deprivation (OGD).	oxygen-glucose	132-146	cAMP responsive element binding protein 1	Mus musculus	96-100
21113126-4	2011	Nicotine-mediated RyR2 upregulation was driven by CREB, and caused a long-lasting reinforcement of Ca2+ signalling via the process of Ca2+-induced Ca2+ release.	Nicotine	0-8	cAMP responsive element binding protein 1	Mus musculus	50-54
22022544-7	2011	The cAMP-CREB system is impaired in A(y)/a mice and these mice have yellow hair as a result of pheomelanogenesis, while Sik2(+/-); A(y)/a mice also have yellow hair, but activate eumelanogenesis when they are exposed to CREB stimulators.	Cyclic AMP	4-8	cAMP responsive element binding protein 1	Mus musculus	9-13
21280179-1	2011	Activating transcription factor 3 (ATF3) is a member of the ATF/CREB (CAMP responsive element binding protein) family of transcription factors.	Cyclic AMP	70-74	cAMP responsive element binding protein 1	Mus musculus	64-68
21297270-5	2011	Our results demonstrate that oral administration of apigenin for Abeta25-35-induced amnesic mice conferred robust neurovascular coupling protection, involving improvement of the learning and memory capabilities, maintenance of neurovascular unit integrity, modulation of microvascular function, reduction of neurovascular oxidative damage, increase of regional cerebral blood flow, improvement of cholinergic system involving the inhibition of AChE activity and elevation of ACh level, and modification of BNDF, TrkB, and phospho-CREB levels.	Apigenin	52-60	cAMP responsive element binding protein 1	Mus musculus	530-534
22022544-7	2011	The cAMP-CREB system is impaired in A(y)/a mice and these mice have yellow hair as a result of pheomelanogenesis, while Sik2(+/-); A(y)/a mice also have yellow hair, but activate eumelanogenesis when they are exposed to CREB stimulators.	Cyclic AMP	4-8	cAMP responsive element binding protein 1	Mus musculus	220-224
21765922-8	2011	In addition, gastrodin blocked LPS-induced phosphorylation of inhibitor kappaB-alpha (IkappaB-alpha) (and hence the activation of NF-kappaB) and of CREB, respectively.	gastrodin	13-22	cAMP responsive element binding protein 1	Mus musculus	148-152
21931637-8	2011	BPA also induced a marked activation of p38 and JNK MAP kinases (on the 30(th) day), glial cells, such as microglia and astrocytes, and the transcription factors CREB and NF-kappaB (at the 5(th) and 30(th) days) in the spinal cord.	bisphenol A	0-3	cAMP responsive element binding protein 1	Mus musculus	162-166
21738744-1	2011	BACKGROUND: The inducible cyclic adenosine monophosphate (cAMP) early repressor (ICER) is highly expressed in the central nervous system and functions as a repressor of cAMP response element-binding protein (CREB) transcription.	Cyclic AMP	26-56	cAMP responsive element binding protein 1	Mus musculus	169-206
21738744-1	2011	BACKGROUND: The inducible cyclic adenosine monophosphate (cAMP) early repressor (ICER) is highly expressed in the central nervous system and functions as a repressor of cAMP response element-binding protein (CREB) transcription.	Cyclic AMP	26-56	cAMP responsive element binding protein 1	Mus musculus	208-212
21738744-1	2011	BACKGROUND: The inducible cyclic adenosine monophosphate (cAMP) early repressor (ICER) is highly expressed in the central nervous system and functions as a repressor of cAMP response element-binding protein (CREB) transcription.	Cyclic AMP	58-62	cAMP responsive element binding protein 1	Mus musculus	169-206
21738744-1	2011	BACKGROUND: The inducible cyclic adenosine monophosphate (cAMP) early repressor (ICER) is highly expressed in the central nervous system and functions as a repressor of cAMP response element-binding protein (CREB) transcription.	Cyclic AMP	58-62	cAMP responsive element binding protein 1	Mus musculus	208-212
21738744-7	2011	Furthermore, Western blot analysis and quantitative real-time reverse transcription polymerase chain reaction demonstrated that ICER overexpression abolished the METH-induced increase in CREB expression and repressed cocaine- and amphetamine-regulated transcript (CART) and prodynorphin (Pdyn) expression in mice.	Methamphetamine	162-166	cAMP responsive element binding protein 1	Mus musculus	187-191
21135157-3	2010	In this study, we employed a tetracycline-inducible CREB repressor mouse strain, in which approximately 60% of the SCN neurons express the transgene, to test CREB functionality in the clock and its effects on overt rhythmicity.	Tetracycline	29-41	cAMP responsive element binding protein 1	Mus musculus	52-56
20978125-6	2010	In gain-of-function studies, adenoviral expression of SOCS3 in primary hepatocytes caused a 50% decrease in 8-br-cAMP-dependent PKA phosphorylation of the transcription factor CREB.	8-br	108-112	cAMP responsive element binding protein 1	Mus musculus	176-180
20978125-6	2010	In gain-of-function studies, adenoviral expression of SOCS3 in primary hepatocytes caused a 50% decrease in 8-br-cAMP-dependent PKA phosphorylation of the transcription factor CREB.	Cyclic AMP	113-117	cAMP responsive element binding protein 1	Mus musculus	176-180
21159975-4	2010	In contrast, in amphetamine- and cocaine-preexposed mice, an amphetamine or cocaine challenge no longer activates CREB unless Ca(v)1.2 LTCCs are blocked.	Amphetamine	16-27	cAMP responsive element binding protein 1	Mus musculus	114-118
21159975-4	2010	In contrast, in amphetamine- and cocaine-preexposed mice, an amphetamine or cocaine challenge no longer activates CREB unless Ca(v)1.2 LTCCs are blocked.	Cocaine	33-40	cAMP responsive element binding protein 1	Mus musculus	114-118
21159975-4	2010	In contrast, in amphetamine- and cocaine-preexposed mice, an amphetamine or cocaine challenge no longer activates CREB unless Ca(v)1.2 LTCCs are blocked.	Amphetamine	61-72	cAMP responsive element binding protein 1	Mus musculus	114-118
21159975-4	2010	In contrast, in amphetamine- and cocaine-preexposed mice, an amphetamine or cocaine challenge no longer activates CREB unless Ca(v)1.2 LTCCs are blocked.	Cocaine	76-83	cAMP responsive element binding protein 1	Mus musculus	114-118
20933581-3	2010	The present study assessed the in vivo effects of cilostazol, a type 3 phosphodiesterase inhibitor known to activate the cAMP-responsive element binding protein (CREB) signaling, on neurogenesis in the ipsilateral SVZ and peri-infarct area in a mouse model of transient middle cerebral artery occlusion.	Cilostazol	50-60	cAMP responsive element binding protein 1	Mus musculus	121-160
20933581-3	2010	The present study assessed the in vivo effects of cilostazol, a type 3 phosphodiesterase inhibitor known to activate the cAMP-responsive element binding protein (CREB) signaling, on neurogenesis in the ipsilateral SVZ and peri-infarct area in a mouse model of transient middle cerebral artery occlusion.	Cilostazol	50-60	cAMP responsive element binding protein 1	Mus musculus	162-166
20933581-9	2010	Cilostazol increased DCX-positive phosphorylated CREB (pCREB)-expressing neural progenitor cells, and increased brain derived neurotrophic factor (BDNF)-expressing astrocytes in the ipsilateral SVZ and peri-infarct area.	Cilostazol	0-10	cAMP responsive element binding protein 1	Mus musculus	49-53
20933581-10	2010	The results indicated that cilostazol enhanced neural progenitor cell generation in both ipsilateral SVZ and peri-infarct area through CREB-mediated signaling pathway after focal ischemia.	Cilostazol	27-37	cAMP responsive element binding protein 1	Mus musculus	135-139
20858484-7	2010	Moreover nuclear factor (NF)-kappaB and other transcription factors like CREB, ATF-2 involved in tumour development and angiogenesis were also inhibited by harmine.	Harmine	156-163	cAMP responsive element binding protein 1	Mus musculus	73-77
21135157-6	2010	However, under conditions of constant light, which typically leads to a lengthening of the circadian period, CREB repressor mice exhibited a dramatic arrhythmic phenotype, which could be reversed with doxycycline.	Doxycycline	201-212	cAMP responsive element binding protein 1	Mus musculus	109-113
20937713-8	2010	Formoterol increased CREB phosphorylation by ~30% (P &lt; 0.05) and PPARgamma coactivator-1alpha (PGC-1alpha) by 11-fold (P &lt; 0.05) on day 1 only.	Formoterol Fumarate	0-10	cAMP responsive element binding protein 1	Mus musculus	21-25
20478382-1	2010	We have previously reported in C2C12 murine skeletal muscle cells that 10(-8)M 17beta-estradiol promotes MAPKs stimulation which in turn mediates the activation of CREB and Elk-1 transcription factors.	Estradiol	79-95	cAMP responsive element binding protein 1	Mus musculus	164-168
20804784-4	2010	NR2B, CaMKIV and CREB1 mRNAs increased significantly in the hippocampus of mice exposed to 50ppm toluene on PND 2-6.	Toluene	97-104	cAMP responsive element binding protein 1	Mus musculus	17-22
20935515-2	2010	Treatment of NG108-15 cells with 1 mM dbcAMP resulted in induction of differentiation, including neurite outgrowth and varicosity formation, enhanced voltage-sensitive Ca2+ channel activity and expression of microtubule-associated protein 2, and these effects involved phosphorylation of cAMP-response element binding protein (CREB) and extracellular signal regulated kinase (ERK).	Bucladesine	38-44	cAMP responsive element binding protein 1	Mus musculus	288-325
20935515-2	2010	Treatment of NG108-15 cells with 1 mM dbcAMP resulted in induction of differentiation, including neurite outgrowth and varicosity formation, enhanced voltage-sensitive Ca2+ channel activity and expression of microtubule-associated protein 2, and these effects involved phosphorylation of cAMP-response element binding protein (CREB) and extracellular signal regulated kinase (ERK).	Bucladesine	38-44	cAMP responsive element binding protein 1	Mus musculus	327-331
20367754-3	2010	Here, we test whether the cAMP-dependent transcription factors cAMP responsive element binding protein (CREB) and cAMP-responsive element modulator (CREM) in noradrenergic neurons control the cellular markers and the physical signs of morphine withdrawal in mice.	Cyclic AMP	26-30	cAMP responsive element binding protein 1	Mus musculus	104-108
20367754-3	2010	Here, we test whether the cAMP-dependent transcription factors cAMP responsive element binding protein (CREB) and cAMP-responsive element modulator (CREM) in noradrenergic neurons control the cellular markers and the physical signs of morphine withdrawal in mice.	Morphine	235-243	cAMP responsive element binding protein 1	Mus musculus	63-102
20367754-3	2010	Here, we test whether the cAMP-dependent transcription factors cAMP responsive element binding protein (CREB) and cAMP-responsive element modulator (CREM) in noradrenergic neurons control the cellular markers and the physical signs of morphine withdrawal in mice.	Morphine	235-243	cAMP responsive element binding protein 1	Mus musculus	104-108
20847309-7	2010	beta-Adrenergic stimulation increased cAMP levels with increased phosphorylation of CREB, leading to increased expression of cAMP-responsive matrix metalloproteinases (MMPs), MMP2, MT1-MMP, and MMP13 in cardiomyocytes and cardiofibroblasts.	Cyclic AMP	125-129	cAMP responsive element binding protein 1	Mus musculus	84-88
20367754-3	2010	Here, we test whether the cAMP-dependent transcription factors cAMP responsive element binding protein (CREB) and cAMP-responsive element modulator (CREM) in noradrenergic neurons control the cellular markers and the physical signs of morphine withdrawal in mice.	Cyclic AMP	26-30	cAMP responsive element binding protein 1	Mus musculus	63-102
20952540-0	2010	CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons.	Serotonin	20-29	cAMP responsive element binding protein 1	Mus musculus	0-4
20952540-3	2010	The signal transduction events elicited by gut-derived serotonin once it binds to the Htr1b receptor present on osteoblasts have been identified and culminate in cAMP response element-binding protein (CREB) regulation of osteoblast proliferation.	Serotonin	55-64	cAMP responsive element binding protein 1	Mus musculus	162-199
20952540-3	2010	The signal transduction events elicited by gut-derived serotonin once it binds to the Htr1b receptor present on osteoblasts have been identified and culminate in cAMP response element-binding protein (CREB) regulation of osteoblast proliferation.	Serotonin	55-64	cAMP responsive element binding protein 1	Mus musculus	201-205
20952540-6	2010	We further show that the transcriptional mediator of these events is CREB, whose phosphorylation on Ser 133 is increased by CaMKIV following serotonin treatment of hypothalamic explants.	Serine	100-103	cAMP responsive element binding protein 1	Mus musculus	69-73
20952540-6	2010	We further show that the transcriptional mediator of these events is CREB, whose phosphorylation on Ser 133 is increased by CaMKIV following serotonin treatment of hypothalamic explants.	Serotonin	141-150	cAMP responsive element binding protein 1	Mus musculus	69-73
20691671-2	2010	Reports on baicalein-induced changes in memory-related biochemical parameters including extracellular signal-regulated kinases (ERK), Akt, cAMP response element-binding protein (CREB), and brain-derived neurotrophic factor (BDNF) have been scarce, and the action of baicalein is controversial.	baicalein	11-20	cAMP responsive element binding protein 1	Mus musculus	139-176
20691671-2	2010	Reports on baicalein-induced changes in memory-related biochemical parameters including extracellular signal-regulated kinases (ERK), Akt, cAMP response element-binding protein (CREB), and brain-derived neurotrophic factor (BDNF) have been scarce, and the action of baicalein is controversial.	baicalein	11-20	cAMP responsive element binding protein 1	Mus musculus	178-182
20478382-9	2010	Accordingly, PP2 and Ro318220 suppressed CREB and Elk-1 phosphorylation as well as c-Fos and c-Jun oncoprotein levels induced by 17beta-estradiol.	Ro 31-8220	21-29	cAMP responsive element binding protein 1	Mus musculus	41-45
20837544-0	2010	Essential role of the cAMP-cAMP response-element binding protein pathway in opiate-induced homeostatic adaptations of locus coeruleus neurons.	Cyclic AMP	22-26	cAMP responsive element binding protein 1	Mus musculus	27-64
20800101-7	2010	Furthermore, the electrophysiological assay showed that PG significantly rescued the long-term potentiation (LTP) impairment in mice hippocampus, and western blotting analysis indicated that the effects of PG on LTP might be attributed to the activation of cAMP-response element-binding protein (CREB).	pg	56-58	cAMP responsive element binding protein 1	Mus musculus	257-294
20800101-7	2010	Furthermore, the electrophysiological assay showed that PG significantly rescued the long-term potentiation (LTP) impairment in mice hippocampus, and western blotting analysis indicated that the effects of PG on LTP might be attributed to the activation of cAMP-response element-binding protein (CREB).	pg	56-58	cAMP responsive element binding protein 1	Mus musculus	296-300
20800101-7	2010	Furthermore, the electrophysiological assay showed that PG significantly rescued the long-term potentiation (LTP) impairment in mice hippocampus, and western blotting analysis indicated that the effects of PG on LTP might be attributed to the activation of cAMP-response element-binding protein (CREB).	pg	206-208	cAMP responsive element binding protein 1	Mus musculus	257-294
20800101-7	2010	Furthermore, the electrophysiological assay showed that PG significantly rescued the long-term potentiation (LTP) impairment in mice hippocampus, and western blotting analysis indicated that the effects of PG on LTP might be attributed to the activation of cAMP-response element-binding protein (CREB).	pg	206-208	cAMP responsive element binding protein 1	Mus musculus	296-300
20852621-2	2010	Elevations in circulating glucagon and epinephrine, two hormones that activate hepatic gluconeogenesis, trigger the cAMP-mediated phosphorylation of cAMP response element-binding protein (Creb) and dephosphorylation of the Creb-regulated transcription coactivator-2 (Crtc2)--two key transcriptional regulators of this process.	Glucagon	26-34	cAMP responsive element binding protein 1	Mus musculus	149-186
20852621-2	2010	Elevations in circulating glucagon and epinephrine, two hormones that activate hepatic gluconeogenesis, trigger the cAMP-mediated phosphorylation of cAMP response element-binding protein (Creb) and dephosphorylation of the Creb-regulated transcription coactivator-2 (Crtc2)--two key transcriptional regulators of this process.	Glucagon	26-34	cAMP responsive element binding protein 1	Mus musculus	188-192
20852621-2	2010	Elevations in circulating glucagon and epinephrine, two hormones that activate hepatic gluconeogenesis, trigger the cAMP-mediated phosphorylation of cAMP response element-binding protein (Creb) and dephosphorylation of the Creb-regulated transcription coactivator-2 (Crtc2)--two key transcriptional regulators of this process.	Epinephrine	39-50	cAMP responsive element binding protein 1	Mus musculus	149-186
20852621-2	2010	Elevations in circulating glucagon and epinephrine, two hormones that activate hepatic gluconeogenesis, trigger the cAMP-mediated phosphorylation of cAMP response element-binding protein (Creb) and dephosphorylation of the Creb-regulated transcription coactivator-2 (Crtc2)--two key transcriptional regulators of this process.	Epinephrine	39-50	cAMP responsive element binding protein 1	Mus musculus	188-192
20852621-2	2010	Elevations in circulating glucagon and epinephrine, two hormones that activate hepatic gluconeogenesis, trigger the cAMP-mediated phosphorylation of cAMP response element-binding protein (Creb) and dephosphorylation of the Creb-regulated transcription coactivator-2 (Crtc2)--two key transcriptional regulators of this process.	Cyclic AMP	116-120	cAMP responsive element binding protein 1	Mus musculus	149-186
20852621-2	2010	Elevations in circulating glucagon and epinephrine, two hormones that activate hepatic gluconeogenesis, trigger the cAMP-mediated phosphorylation of cAMP response element-binding protein (Creb) and dephosphorylation of the Creb-regulated transcription coactivator-2 (Crtc2)--two key transcriptional regulators of this process.	Cyclic AMP	116-120	cAMP responsive element binding protein 1	Mus musculus	188-192
20837544-6	2010	Overexpression of a dominant negative CREB mutant blocked the increase in LC excitability induced by morphine- or cAMP-pathway activation.	Morphine	101-109	cAMP responsive element binding protein 1	Mus musculus	38-42
20837544-6	2010	Overexpression of a dominant negative CREB mutant blocked the increase in LC excitability induced by morphine- or cAMP-pathway activation.	Cyclic AMP	114-118	cAMP responsive element binding protein 1	Mus musculus	38-42
20837544-8	2010	Furthermore, the ability of morphine or CREB overexpression to up-regulate LC firing was blocked by knockout of the CREB target adenylyl cyclase 8.	Morphine	28-36	cAMP responsive element binding protein 1	Mus musculus	116-120
20837544-9	2010	Together, these findings provide direct evidence that prolonged exposure to morphine induces homeostatic plasticity intrinsic to LC neurons, involving up-regulation of the cAMP-CREB signaling pathway, which then enhances LC neuronal excitability.	Morphine	76-84	cAMP responsive element binding protein 1	Mus musculus	177-181
20837544-9	2010	Together, these findings provide direct evidence that prolonged exposure to morphine induces homeostatic plasticity intrinsic to LC neurons, involving up-regulation of the cAMP-CREB signaling pathway, which then enhances LC neuronal excitability.	Cyclic AMP	172-176	cAMP responsive element binding protein 1	Mus musculus	177-181
20592469-6	2010	Further analysis in MIN6 cells demonstrated that TRB3 interacted with the transcription factor ATF4 and that this complex acted as a competitive inhibitor of cAMP response element-binding (CREB) transcription factor in the regulation of key exocytosis genes.	Cyclic AMP	158-162	cAMP responsive element binding protein 1	Mus musculus	189-193
20571078-10	2010	Moreover, [d-Ala(2),N-MePhe(4),Gly-ol(5)]enkephalin (DAMGO) treatment increased both reporter promoter activity and Sult4a1 levels in mu-opioid receptor expressing Neuro2a/mu-opioid receptor cells, and EMSAs showed this to be due to increased binding of CREB and ATF-2 to the Sult4a1 promoter.	n-mephe	20-27	cAMP responsive element binding protein 1	Mus musculus	254-258
20571078-10	2010	Moreover, [d-Ala(2),N-MePhe(4),Gly-ol(5)]enkephalin (DAMGO) treatment increased both reporter promoter activity and Sult4a1 levels in mu-opioid receptor expressing Neuro2a/mu-opioid receptor cells, and EMSAs showed this to be due to increased binding of CREB and ATF-2 to the Sult4a1 promoter.	Glycine	31-34	cAMP responsive element binding protein 1	Mus musculus	254-258
24278522-2	2010	C57BL/6 male mice were treated with rolipram (1.25 mg/kg, i.p., twice a day for 5 consecutive days) to activate the cAMP/CREB pathway against cranial irradiation (2 Gy) , and were euthanized at 24 h post-irradiation.	Rolipram	36-44	cAMP responsive element binding protein 1	Mus musculus	121-125
24278522-4	2010	However, the rolipram treatment protected from gamma-irradiation-induced decreases of CREB phosphorylation, and Ki-67 and DCX immunoreactivity in the hippocampal DG.	Rolipram	13-21	cAMP responsive element binding protein 1	Mus musculus	86-90
20739549-7	2010	The analysis of the intracellular signaling cascade that lay downstream the activated NMDA receptor revealed an unexpected reactivation of the CaMKII/AKT/CREB (cAMP response element-binding protein) pathway that induced an enhanced SMN expression.	Cyclic AMP	160-164	cAMP responsive element binding protein 1	Mus musculus	154-158
20691161-8	2010	These effects were coupled by an increased phosphorylation of cAMP-responsive element (CRE) binding protein (CREB).	Cyclic AMP	62-66	cAMP responsive element binding protein 1	Mus musculus	109-113
20551288-0	2010	Phosphorylation of the CREB-specific coactivator TORC2 at Ser(307) regulates its intracellular localization in COS-7 cells and in the mouse liver.	Serine	58-61	cAMP responsive element binding protein 1	Mus musculus	23-27
20551288-0	2010	Phosphorylation of the CREB-specific coactivator TORC2 at Ser(307) regulates its intracellular localization in COS-7 cells and in the mouse liver.	carbonyl sulfide	111-114	cAMP responsive element binding protein 1	Mus musculus	23-27
20493822-2	2010	Here we investigated the ability of caffeine to stimulate CREB-dependent gene transcription in primary cultures of developing mouse cortical neurons.	Caffeine	36-44	cAMP responsive element binding protein 1	Mus musculus	58-62
20403362-4	2010	This effect of cicaprost was unlikely to be mediated by inhibition of the Smad2/3 or mitogen-activated protein kinase (MAPK) activities, but was associated with cAMP elevation and phosphorylation of the transcription factor cAMP response element binding protein (CREB).	cicaprost	15-24	cAMP responsive element binding protein 1	Mus musculus	224-261
20403362-4	2010	This effect of cicaprost was unlikely to be mediated by inhibition of the Smad2/3 or mitogen-activated protein kinase (MAPK) activities, but was associated with cAMP elevation and phosphorylation of the transcription factor cAMP response element binding protein (CREB).	cicaprost	15-24	cAMP responsive element binding protein 1	Mus musculus	263-267
20403362-5	2010	Expression of a non-phosphorylated CREB mutant suppressed the inhibitory effect of cicaprost.	cicaprost	83-92	cAMP responsive element binding protein 1	Mus musculus	35-39
20403362-9	2010	Taken together, our results suggest that the prostacyclin/IP pathway suppresses cardiac fibrosis, at least partly, by inducing CREB phosphorylation.	Epoprostenol	45-57	cAMP responsive element binding protein 1	Mus musculus	127-131
20403362-9	2010	Taken together, our results suggest that the prostacyclin/IP pathway suppresses cardiac fibrosis, at least partly, by inducing CREB phosphorylation.	ip	58-60	cAMP responsive element binding protein 1	Mus musculus	127-131
21977292-8	2010	Moreover, in support of a role for carbamaze -pine as a beta-adrenergic antagonist via cAMP inhibition, a lower heart rate and a lower level of the activated phosphorylated form of the cAMP Response Element-Binding (CREB) were observed in heart extracts from mice treated with carbamazepine.	Carbamazepine	277-290	cAMP responsive element binding protein 1	Mus musculus	185-214
21977292-8	2010	Moreover, in support of a role for carbamaze -pine as a beta-adrenergic antagonist via cAMP inhibition, a lower heart rate and a lower level of the activated phosphorylated form of the cAMP Response Element-Binding (CREB) were observed in heart extracts from mice treated with carbamazepine.	Carbamazepine	277-290	cAMP responsive element binding protein 1	Mus musculus	216-220
20122921-0	2010	A common mechanism of action of the selective serotonin reuptake inhibitors citalopram and fluoxetine: reversal of chronic psychosocial stress-induced increase in CRE/CREB-directed gene transcription in transgenic reporter gene mice.	Citalopram	76-86	cAMP responsive element binding protein 1	Mus musculus	167-171
20613939-2	2010	We hypothesized that HSPTX exerts its anti-inflammatory effects by interfering with nuclear factor kappa B/cAMP response element-binding protein (NF-kappaB-CREB) competition for the coactivator CREB-binding protein (CBP) in lung tissue, thus affecting pro-inflammatory mediator production.	hsptx	21-26	cAMP responsive element binding protein 1	Mus musculus	156-160
20613939-2	2010	We hypothesized that HSPTX exerts its anti-inflammatory effects by interfering with nuclear factor kappa B/cAMP response element-binding protein (NF-kappaB-CREB) competition for the coactivator CREB-binding protein (CBP) in lung tissue, thus affecting pro-inflammatory mediator production.	Cyclic AMP	107-111	cAMP responsive element binding protein 1	Mus musculus	156-160
20613939-10	2010	NF-kappaB-CBP-binding activity was similar in both groups, whereas CREB-CBP-binding activity was significantly increased with HSPTX.	hsptx	126-131	cAMP responsive element binding protein 1	Mus musculus	67-71
20348015-11	2010	These results indicate that AR mediates LPS-induced glucose uptake and expression of glucose transporter-3 via cAMP/PKA/CREB pathway and thus represents a novel mechanism by which AR regulates LPS-induced inflammation.	Glucose	52-59	cAMP responsive element binding protein 1	Mus musculus	120-124
20348015-11	2010	These results indicate that AR mediates LPS-induced glucose uptake and expression of glucose transporter-3 via cAMP/PKA/CREB pathway and thus represents a novel mechanism by which AR regulates LPS-induced inflammation.	Cyclic AMP	111-115	cAMP responsive element binding protein 1	Mus musculus	120-124
20122921-0	2010	A common mechanism of action of the selective serotonin reuptake inhibitors citalopram and fluoxetine: reversal of chronic psychosocial stress-induced increase in CRE/CREB-directed gene transcription in transgenic reporter gene mice.	Fluoxetine	91-101	cAMP responsive element binding protein 1	Mus musculus	167-171
20122921-2	2010	Recently, chronic psychosocial stress as animal model of depression has been shown to stimulate CREB transcriptional activity in the brain; this stimulation was prevented by treatment with the antidepressant imipramine, which inhibits both noradrenaline and serotonin reuptake.	Imipramine	208-218	cAMP responsive element binding protein 1	Mus musculus	96-100
20122921-2	2010	Recently, chronic psychosocial stress as animal model of depression has been shown to stimulate CREB transcriptional activity in the brain; this stimulation was prevented by treatment with the antidepressant imipramine, which inhibits both noradrenaline and serotonin reuptake.	Norepinephrine	240-253	cAMP responsive element binding protein 1	Mus musculus	96-100
20122921-2	2010	Recently, chronic psychosocial stress as animal model of depression has been shown to stimulate CREB transcriptional activity in the brain; this stimulation was prevented by treatment with the antidepressant imipramine, which inhibits both noradrenaline and serotonin reuptake.	Serotonin	258-267	cAMP responsive element binding protein 1	Mus musculus	96-100
20122921-3	2010	However, it was unknown whether the selective inhibition of serotonin reuptake is sufficient for inhibition of stress-induced CREB activation, as it is for the clinical antidepressant effect.	Serotonin	60-69	cAMP responsive element binding protein 1	Mus musculus	126-130
20122921-8	2010	However, both citalopram and fluoxetine treatment completely abolished the increase in CRE/CREB-directed transcription induced by chronic psychosocial stress.	Citalopram	14-24	cAMP responsive element binding protein 1	Mus musculus	91-95
20122921-8	2010	However, both citalopram and fluoxetine treatment completely abolished the increase in CRE/CREB-directed transcription induced by chronic psychosocial stress.	Fluoxetine	29-39	cAMP responsive element binding protein 1	Mus musculus	91-95
20122921-9	2010	As indicated by Western blots, the changes in CRE/CREB-directed transcription were accompanied by corresponding changes in the phosphorylation of CREB at serine-119.	Serine	154-160	cAMP responsive element binding protein 1	Mus musculus	50-54
20122921-9	2010	As indicated by Western blots, the changes in CRE/CREB-directed transcription were accompanied by corresponding changes in the phosphorylation of CREB at serine-119.	Serine	154-160	cAMP responsive element binding protein 1	Mus musculus	146-150
20171263-7	2010	In the hippocampus, CREB phosphorylation increases following activation of NO/cGMP signalling contributing to the late phase of LTP.	Cyclic GMP	78-82	cAMP responsive element binding protein 1	Mus musculus	20-24
19902350-7	2010	The GraL GAD(67) level may be regulated by the activation of CREB, as the phosphorylated (p) CREB coexisted with GAD(67), and the percentage of GAD(67)-expressing pCREB neurons was decreased by the amphetamine exposure.	Amphetamine	198-209	cAMP responsive element binding protein 1	Mus musculus	61-65
20405001-12	2010	More importantly, an intravenous 4-d treatment with spadin not only induced a strong antidepressant effect but also enhanced hippocampal phosphorylation of CREB protein and neurogenesis, considered to be key markers of antidepressant action after chronic treatment with selective serotonin reuptake inhibitors.	4-d	33-36	cAMP responsive element binding protein 1	Mus musculus	156-160
20405001-12	2010	More importantly, an intravenous 4-d treatment with spadin not only induced a strong antidepressant effect but also enhanced hippocampal phosphorylation of CREB protein and neurogenesis, considered to be key markers of antidepressant action after chronic treatment with selective serotonin reuptake inhibitors.	Spadin	52-58	cAMP responsive element binding protein 1	Mus musculus	156-160
20163788-9	2010	Overexpressing mCREB within the orbitofrontal cortex blocked yohimbine"s effects on impulsivity, whereas overexpressing CREB in this region increased impulsive responding and potentiated the proimpulsive actions of yohimbine.	Yohimbine	61-70	cAMP responsive element binding protein 1	Mus musculus	15-20
20171263-9	2010	Supporting our hypothesis, marked CREB phosphorylation and CRE-mediated transcription was induced by cGMP in the lateral amygdala of control mice, but not in cGKI-deficient mice.	Cyclic GMP	101-105	cAMP responsive element binding protein 1	Mus musculus	34-38
19821778-4	2010	On electrophoretic mobility shift analysis, PTH stimulated binding of phosphorylated CREB to an oligonucleotide spanning the CRE and binding of NFATc1, c-Fos, and c-Jun to an oligonucleotide spanning the NFAT/AP-1 composite site.	Oligonucleotides	96-111	cAMP responsive element binding protein 1	Mus musculus	85-89
20003619-5	2010	Congruent with these data, we observed that short-term repeated administration of citalopram was accompanied by increased activation of cAMP response element-binding protein (CREB) in the hippocampus and desensitization of 5-HT1A receptors, two phenomena well associated with chronic rather than acute actions of antidepressants.	Citalopram	82-92	cAMP responsive element binding protein 1	Mus musculus	136-173
20003619-5	2010	Congruent with these data, we observed that short-term repeated administration of citalopram was accompanied by increased activation of cAMP response element-binding protein (CREB) in the hippocampus and desensitization of 5-HT1A receptors, two phenomena well associated with chronic rather than acute actions of antidepressants.	Citalopram	82-92	cAMP responsive element binding protein 1	Mus musculus	175-179
20003619-9	2010	These data demonstrate that behavioural responses to citalopram are dependent on the frequency of its administration, and that these responses are differentially dependent on CREB function.	Citalopram	53-63	cAMP responsive element binding protein 1	Mus musculus	175-179
19922425-0	2010	The ceramide-1-phosphate analogue PCERA-1 modulates tumour necrosis factor-alpha and interleukin-10 production in macrophages via the cAMP-PKA-CREB pathway in a GTP-dependent manner.	ceramide 1-phosphate	4-24	cAMP responsive element binding protein 1	Mus musculus	143-147
19908280-5	2010	Transient up-regulation of cAMP-CREB signaling partially inhibited apoptosis of mouse OPCs independently of the ERK pathway.	Cyclic AMP	27-31	cAMP responsive element binding protein 1	Mus musculus	32-36
20154710-9	2010	CONCLUSION: FLZ exerted neuroprotection at least partly through enhancing the BDNF/TrkB/CREB pathway and inhibiting neuronal apoptosis in APP/PS1 mice, which suggests that FLZ can be explored as a potential therapeutic agent in long-term Alzheimer"s disease therapy.	flz	172-175	cAMP responsive element binding protein 1	Mus musculus	88-92
20067582-9	2010	Transfecting H19-7 and b.End3 cells with a serine-133 phosphorylation mutant CREB also inhibited VEGF-A"s protection of both types of cells.	Serine	43-49	cAMP responsive element binding protein 1	Mus musculus	77-81
20154710-0	2010	The novel squamosamide derivative FLZ enhances BDNF/TrkB/CREB signaling and inhibits neuronal apoptosis in APP/PS1 mice.	squamosamide	10-22	cAMP responsive element binding protein 1	Mus musculus	57-61
20154710-0	2010	The novel squamosamide derivative FLZ enhances BDNF/TrkB/CREB signaling and inhibits neuronal apoptosis in APP/PS1 mice.	flz	34-37	cAMP responsive element binding protein 1	Mus musculus	57-61
20154710-1	2010	AIM: The aim of this study was to study the effects of compound FLZ, a novel cyclic derivative of squamosamide from Annona glabra, on brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B (TrkB)/cAMP response element-binding protein (CREB) signaling and neuronal apoptosis in the hippocampus of the amyloid precursor protein (APP)/presenilin-1 (PS1) double transgenic mice.	flz	64-67	cAMP responsive element binding protein 1	Mus musculus	251-255
20154710-7	2010	In addition, FLZ promoted BDNF high-affinity receptor TrkB phosphorylation and activated its downstream ERK, thus increasing phosphorylation of CREB at Ser133 in the hippocampus of APP/PS1 mice.	flz	13-16	cAMP responsive element binding protein 1	Mus musculus	144-148
20154710-9	2010	CONCLUSION: FLZ exerted neuroprotection at least partly through enhancing the BDNF/TrkB/CREB pathway and inhibiting neuronal apoptosis in APP/PS1 mice, which suggests that FLZ can be explored as a potential therapeutic agent in long-term Alzheimer"s disease therapy.	flz	12-15	cAMP responsive element binding protein 1	Mus musculus	88-92
19922425-0	2010	The ceramide-1-phosphate analogue PCERA-1 modulates tumour necrosis factor-alpha and interleukin-10 production in macrophages via the cAMP-PKA-CREB pathway in a GTP-dependent manner.	Cyclic AMP	134-138	cAMP responsive element binding protein 1	Mus musculus	143-147
19922425-0	2010	The ceramide-1-phosphate analogue PCERA-1 modulates tumour necrosis factor-alpha and interleukin-10 production in macrophages via the cAMP-PKA-CREB pathway in a GTP-dependent manner.	Guanosine Triphosphate	161-164	cAMP responsive element binding protein 1	Mus musculus	143-147
19922425-6	2010	Consistently, the PKA inhibitor H89 efficiently blocked PCERA-1-driven cytokine modulation as well as PCERA-1-stimulated phosphorylation of cAMP response element binding protein (CREB) on Ser-133.	Serine	188-191	cAMP responsive element binding protein 1	Mus musculus	140-177
19922425-6	2010	Consistently, the PKA inhibitor H89 efficiently blocked PCERA-1-driven cytokine modulation as well as PCERA-1-stimulated phosphorylation of cAMP response element binding protein (CREB) on Ser-133.	Serine	188-191	cAMP responsive element binding protein 1	Mus musculus	179-183
19922425-8	2010	Our results suggest that PCERA-1 activates a G(s) protein-coupled receptor, leading to elevation of cAMP, which acts via the PKA-CREB pathway to promote TNF-alpha suppression and IL-10 induction in LPS-stimulated macrophages.	Cyclic AMP	100-104	cAMP responsive element binding protein 1	Mus musculus	129-133
19776387-1	2010	The expression of two members of an important family of transcription factors, cAMP response element-binding protein (CREB) and cAMP-dependent transcription factor ATF1 (ATF1), is essential for normal preimplantation development.	Cyclic AMP	79-83	cAMP responsive element binding protein 1	Mus musculus	118-122
19968777-1	2010	BACKGROUND/AIMS: Transcription factors coupled to cyclic adenosine mono phosphate (cAMP) signalling in the cAMP-responsive elements binding (CREB)/ATF family constitute a family of activators or repressors that bind to cAMP-responsive promoter elements (CREs) in the regulatory regions of cAMP-inducible genes.	Cyclic AMP	50-81	cAMP responsive element binding protein 1	Mus musculus	107-139
19968777-1	2010	BACKGROUND/AIMS: Transcription factors coupled to cyclic adenosine mono phosphate (cAMP) signalling in the cAMP-responsive elements binding (CREB)/ATF family constitute a family of activators or repressors that bind to cAMP-responsive promoter elements (CREs) in the regulatory regions of cAMP-inducible genes.	Cyclic AMP	50-81	cAMP responsive element binding protein 1	Mus musculus	141-145
19968777-1	2010	BACKGROUND/AIMS: Transcription factors coupled to cyclic adenosine mono phosphate (cAMP) signalling in the cAMP-responsive elements binding (CREB)/ATF family constitute a family of activators or repressors that bind to cAMP-responsive promoter elements (CREs) in the regulatory regions of cAMP-inducible genes.	Cyclic AMP	83-87	cAMP responsive element binding protein 1	Mus musculus	107-139
19968777-1	2010	BACKGROUND/AIMS: Transcription factors coupled to cyclic adenosine mono phosphate (cAMP) signalling in the cAMP-responsive elements binding (CREB)/ATF family constitute a family of activators or repressors that bind to cAMP-responsive promoter elements (CREs) in the regulatory regions of cAMP-inducible genes.	Cyclic AMP	83-87	cAMP responsive element binding protein 1	Mus musculus	141-145
19968777-1	2010	BACKGROUND/AIMS: Transcription factors coupled to cyclic adenosine mono phosphate (cAMP) signalling in the cAMP-responsive elements binding (CREB)/ATF family constitute a family of activators or repressors that bind to cAMP-responsive promoter elements (CREs) in the regulatory regions of cAMP-inducible genes.	Cyclic AMP	107-111	cAMP responsive element binding protein 1	Mus musculus	141-145
19968777-1	2010	BACKGROUND/AIMS: Transcription factors coupled to cyclic adenosine mono phosphate (cAMP) signalling in the cAMP-responsive elements binding (CREB)/ATF family constitute a family of activators or repressors that bind to cAMP-responsive promoter elements (CREs) in the regulatory regions of cAMP-inducible genes.	Cyclic AMP	107-111	cAMP responsive element binding protein 1	Mus musculus	141-145
19968777-3	2010	CREB appears to be activated by the X protein of hepatitis B virus, which links to the unphosphorylated form of CREB and activates transcription, thus obviating an otherwise indispensable Ser-133 phosphorylation.	Serine	188-191	cAMP responsive element binding protein 1	Mus musculus	0-4
19968777-7	2010	We demonstrated that VTIP-P physically interacts with the activation domain (AD) of the transcription factors CREB/CREM and activates transcription by modifying their phosphorylation pattern in hepatoma cells.	vtip-p	21-27	cAMP responsive element binding protein 1	Mus musculus	110-114
19968777-8	2010	The data allowed the conclusion that VTIP-P binds the AD of CREB and CREM by stabilizing their phosphorylation.	vtip-p	37-43	cAMP responsive element binding protein 1	Mus musculus	60-64
20164327-9	2010	Additionally, NAN-190 decreased and 8-OH-DPAT increased phosphorylated cAMP response element-binding protein (CREB) levels in WT mice but not in KO mice.	8-Hydroxy-2-(di-n-propylamino)tetralin	36-45	cAMP responsive element binding protein 1	Mus musculus	71-108
20164327-9	2010	Additionally, NAN-190 decreased and 8-OH-DPAT increased phosphorylated cAMP response element-binding protein (CREB) levels in WT mice but not in KO mice.	8-Hydroxy-2-(di-n-propylamino)tetralin	36-45	cAMP responsive element binding protein 1	Mus musculus	110-114
20164327-10	2010	Blockade of hippocampal CREB phosphorylation by microinjection of H89 (5.19 microg/1.0 microl), a PKA (protein kinase A) inhibitor, abolished the anxiolytic-like effects of 7-NI (i.p., 30 mg/kg/d for 21 d).	7-nitroindazole	173-177	cAMP responsive element binding protein 1	Mus musculus	24-28
20209163-1	2010	Calcium-calmodulin dependent protein kinase IV (CaMKIV) is a protein kinase that activates the transcription factor CREB, the cyclic AMP-response element binding protein.	Cyclic AMP	126-136	cAMP responsive element binding protein 1	Mus musculus	116-120
20133702-1	2010	Under fasting conditions, increases in circulating concentrations of pancreatic glucagon maintain glucose homeostasis through induction of gluconeogenic genes by the CREB coactivator CRTC2.	Glucose	98-105	cAMP responsive element binding protein 1	Mus musculus	166-170
20133702-5	2010	Deletion of sequences encoding the CREB binding domain in CRTC2 (-/-) mice lowered circulating blood glucose concentrations and improved insulin sensitivity in the context of diet-induced obesity.	Glucose	101-108	cAMP responsive element binding protein 1	Mus musculus	35-39
19776387-4	2010	Activation of these transcription factors requires their phosphorylation, and this was only observed to occur for both transcription factors (serine 133 phosphorylation of CREB and serine 63 phosphorylation of ATF1) at the two-cell stage.	Serine	142-148	cAMP responsive element binding protein 1	Mus musculus	172-176
19776387-6	2010	The nuclear localization and phosphorylation of CREB showed a constitutive component that was further induced by the autocrine embryotropin Paf (1-o-alkyl-2-acetyl-sn-glycero-3-phosphocholine).	Platelet Activating Factor	145-191	cAMP responsive element binding protein 1	Mus musculus	48-52
19776387-7	2010	Activation of CREB by Paf was independent of cAMP but was dependent on calcium, calmodulin, and calmodulin-dependent kinase activity.	Cyclic AMP	45-49	cAMP responsive element binding protein 1	Mus musculus	14-18
19903493-8	2010	Further investigation confirmed that the effect of dbcAMP on production of TH-positive neurons was mediated through cyclic AMP (cAMP) responsive element binding protein (CREB) and it was antagonized by RA.	Bucladesine	51-57	cAMP responsive element binding protein 1	Mus musculus	170-174
19997843-2	2010	These systems converge on an intracellular signaling pathway that involves protein kinase A-dependent phosphorylation of different proteins including cyclic adenosine monophosphate response element binding (CREB).	Cyclic AMP	150-180	cAMP responsive element binding protein 1	Mus musculus	207-211
19997843-9	2010	Interestingly, the effect of PCP on phospho-S(133)-CREB but not on phospho-T(34)-DARPP32 was dependent on endogenous 5-HT.	Phencyclidine	29-32	cAMP responsive element binding protein 1	Mus musculus	51-55
19903493-8	2010	Further investigation confirmed that the effect of dbcAMP on production of TH-positive neurons was mediated through cyclic AMP (cAMP) responsive element binding protein (CREB) and it was antagonized by RA.	Cyclic AMP	116-126	cAMP responsive element binding protein 1	Mus musculus	170-174
19962768-8	2010	Clozapine also reversed some of the sensitization-induced biochemical changes, including increased phosphorylation of GSK-3beta and CREB, in the frontal cortex.	Clozapine	0-9	cAMP responsive element binding protein 1	Mus musculus	132-136
19903493-8	2010	Further investigation confirmed that the effect of dbcAMP on production of TH-positive neurons was mediated through cyclic AMP (cAMP) responsive element binding protein (CREB) and it was antagonized by RA.	Cyclic AMP	53-57	cAMP responsive element binding protein 1	Mus musculus	170-174
20070884-2	2010	Our previous study has shown that the induction of dynein light chain (DLC) by cAMP response element-binding protein (CREB) is required for cAMP-mediated inhibition of mitogen-activated protein kinase (MAPK) p38 activation in fibroblasts, which leads to suppression of NF-kappaB activity and promotion of tumor necrosis factor-alpha (TNF-alpha)-induced cell death.	Cyclic AMP	79-83	cAMP responsive element binding protein 1	Mus musculus	118-122
20070884-10	2010	RESULTS: Elevation of cAMP suppressed TNF-alpha-induced necrotic cell death in L929 fibroblastoma cells via CREB-mediated transcription.	Cyclic AMP	22-26	cAMP responsive element binding protein 1	Mus musculus	108-112
19861415-0	2010	Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression.	PQQ Cofactor	0-24	cAMP responsive element binding protein 1	Mus musculus	69-106
20157253-0	2010	Ginsenoside Rg1 attenuates amyloid-beta content, regulates PKA/CREB activity, and improves cognitive performance in SAMP8 mice.	ginsenoside Rg1	0-15	cAMP responsive element binding protein 1	Mus musculus	63-67
20157253-7	2010	In contrast, phospho-CREB and brain derived neurotrophic factor (BDNF) levels were dramatically increased in the hippocampus of SAMP8 treated with Rg1.	ginsenoside Rg1	147-150	cAMP responsive element binding protein 1	Mus musculus	21-25
20157253-9	2010	These data suggest that long-term consumption of ginsenoside Rg1 may delay cognitive decline, associated with significant effects on Abeta generation, PKA/CREB activity, as well as BDNF content in the brain.	ginsenoside Rg1	49-64	cAMP responsive element binding protein 1	Mus musculus	155-159
20023170-5	2010	Moreover, we identified a cAMP responsive element (Cre) motif located at -1307 to -1300 bp in the ERalpha promoter that is able to interact with Cre binding protein (Creb).	Cyclic AMP	26-30	cAMP responsive element binding protein 1	Mus musculus	145-164
20023170-5	2010	Moreover, we identified a cAMP responsive element (Cre) motif located at -1307 to -1300 bp in the ERalpha promoter that is able to interact with Cre binding protein (Creb).	Cyclic AMP	26-30	cAMP responsive element binding protein 1	Mus musculus	166-170
19861415-6	2010	PQQ exposure stimulated phosphorylation of CREB at serine 133, activated the promoter of PGC-1alpha, and increased PGC-1alpha mRNA and protein expression.	PQQ Cofactor	0-3	cAMP responsive element binding protein 1	Mus musculus	43-47
19861415-6	2010	PQQ exposure stimulated phosphorylation of CREB at serine 133, activated the promoter of PGC-1alpha, and increased PGC-1alpha mRNA and protein expression.	Serine	51-57	cAMP responsive element binding protein 1	Mus musculus	43-47
19932712-7	2010	Then, we also examined the expression of transcription factor, dopamine markers and oxidative stress marker in the hippocampus of sensitive strain C3H/HeN mice and found that the expression of CREB1 mRNA was significantly increased at 50 ppm toluene.	Dopamine	63-71	cAMP responsive element binding protein 1	Mus musculus	193-198
21196914-6	2010	Meanwhile, content of cAMP and phosphorylation of cAMP-response element-binding (CREB) in the lymphocytes were examined by 125I-cAMP radioimmunoassay and Western blot assay, respectively.	Cyclic AMP	50-54	cAMP responsive element binding protein 1	Mus musculus	81-85
21196914-6	2010	Meanwhile, content of cAMP and phosphorylation of cAMP-response element-binding (CREB) in the lymphocytes were examined by 125I-cAMP radioimmunoassay and Western blot assay, respectively.	Cyclic AMP	50-54	cAMP responsive element binding protein 1	Mus musculus	81-85
21196914-11	2010	Meanwhile, the quinpirole diminished the cAMP content and the phosphorylated CREB level in the lymphocytes.	Quinpirole	15-25	cAMP responsive element binding protein 1	Mus musculus	77-81
21196914-15	2010	D2-like receptors are involved in suppression of T helper 1 (Th1) cell function and enhancement of Th2 cell function through negative link to cAMP-CREB pathway.	Cyclic AMP	142-146	cAMP responsive element binding protein 1	Mus musculus	147-151
19932712-7	2010	Then, we also examined the expression of transcription factor, dopamine markers and oxidative stress marker in the hippocampus of sensitive strain C3H/HeN mice and found that the expression of CREB1 mRNA was significantly increased at 50 ppm toluene.	Toluene	242-249	cAMP responsive element binding protein 1	Mus musculus	193-198
19915593-5	2009	In contrast, stimulation of extrasynaptic NMDARs increases the vulnerability of mtHtt-containing neurons to cell death by impairing the neuroprotective cyclic AMP response element-binding protein (CREB)-peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) cascade and increasing the level of the small guanine nucleotide-binding protein Rhes, which is known to sumoylate and disaggregate mtHtt.	mthtt	80-85	cAMP responsive element binding protein 1	Mus musculus	152-195
19830406-7	2010	Basal expression of p-CREB (but not BDNF) was higher in D (1) (-/-) than D (1) (+/+) mice and was reduced after amphetamine treatment.	Amphetamine	112-123	cAMP responsive element binding protein 1	Mus musculus	22-26
19838724-7	2009	The levels of CREB in the SMG were increased by castration in males and decreased by repeated administration of testosterone to females or castrated males.	Testosterone	112-124	cAMP responsive element binding protein 1	Mus musculus	14-18
19838724-8	2009	From 3 h after a single administration of testosterone to females, many SD cells temporarily gained nuclear immunoreactivity for both t- and p-CREB, which was lost as the cells were converted to GCT cells by 24 h. These results suggest the involvement of CREB in the androgen-dependent differentiation of the duct system in the mouse SMG.	Testosterone	42-54	cAMP responsive element binding protein 1	Mus musculus	143-147
19838724-8	2009	From 3 h after a single administration of testosterone to females, many SD cells temporarily gained nuclear immunoreactivity for both t- and p-CREB, which was lost as the cells were converted to GCT cells by 24 h. These results suggest the involvement of CREB in the androgen-dependent differentiation of the duct system in the mouse SMG.	Testosterone	42-54	cAMP responsive element binding protein 1	Mus musculus	255-259
19880655-10	2009	Finally, mRLD6 was also a target for forskolin-induced cellular response element-binding protein (CREB) recruitment, which potentiated cytokine activity.	Colforsin	37-46	cAMP responsive element binding protein 1	Mus musculus	98-102
19915593-5	2009	In contrast, stimulation of extrasynaptic NMDARs increases the vulnerability of mtHtt-containing neurons to cell death by impairing the neuroprotective cyclic AMP response element-binding protein (CREB)-peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) cascade and increasing the level of the small guanine nucleotide-binding protein Rhes, which is known to sumoylate and disaggregate mtHtt.	mthtt	80-85	cAMP responsive element binding protein 1	Mus musculus	197-201
19915593-5	2009	In contrast, stimulation of extrasynaptic NMDARs increases the vulnerability of mtHtt-containing neurons to cell death by impairing the neuroprotective cyclic AMP response element-binding protein (CREB)-peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) cascade and increasing the level of the small guanine nucleotide-binding protein Rhes, which is known to sumoylate and disaggregate mtHtt.	Guanine Nucleotides	330-348	cAMP responsive element binding protein 1	Mus musculus	152-195
19915593-5	2009	In contrast, stimulation of extrasynaptic NMDARs increases the vulnerability of mtHtt-containing neurons to cell death by impairing the neuroprotective cyclic AMP response element-binding protein (CREB)-peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) cascade and increasing the level of the small guanine nucleotide-binding protein Rhes, which is known to sumoylate and disaggregate mtHtt.	Guanine Nucleotides	330-348	cAMP responsive element binding protein 1	Mus musculus	197-201
19915593-5	2009	In contrast, stimulation of extrasynaptic NMDARs increases the vulnerability of mtHtt-containing neurons to cell death by impairing the neuroprotective cyclic AMP response element-binding protein (CREB)-peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) cascade and increasing the level of the small guanine nucleotide-binding protein Rhes, which is known to sumoylate and disaggregate mtHtt.	mthtt	416-421	cAMP responsive element binding protein 1	Mus musculus	152-195
19915593-5	2009	In contrast, stimulation of extrasynaptic NMDARs increases the vulnerability of mtHtt-containing neurons to cell death by impairing the neuroprotective cyclic AMP response element-binding protein (CREB)-peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) cascade and increasing the level of the small guanine nucleotide-binding protein Rhes, which is known to sumoylate and disaggregate mtHtt.	mthtt	416-421	cAMP responsive element binding protein 1	Mus musculus	197-201
19812345-0	2009	Autocrine activation of neuronal NMDA receptors by aspartate mediates dopamine- and cAMP-induced CREB-dependent gene transcription.	Aspartic Acid	51-60	cAMP responsive element binding protein 1	Mus musculus	97-101
19632326-3	2009	In the 3-nitropropionic acid (3-NP) model, CREB phospho-activation in the striatum was potently repressed within the neurotoxic "core" region prior to cell death.	3-nitropropionic acid	7-28	cAMP responsive element binding protein 1	Mus musculus	43-47
19632326-3	2009	In the 3-nitropropionic acid (3-NP) model, CREB phospho-activation in the striatum was potently repressed within the neurotoxic "core" region prior to cell death.	3-nitropropionic acid	30-34	cAMP responsive element binding protein 1	Mus musculus	43-47
19632326-6	2009	3-NP-induced striatal lesion size and motor dysfunction were significantly increased in A-CREB mice compared to controls.	3-nitropropionic acid	0-4	cAMP responsive element binding protein 1	Mus musculus	90-94
19596052-5	2009	The activity of the protein kinase A/cAMP-response element binding protein (PKA/CREB) pathway, one of the molecular targets of Abeta oligomers which is crucial for late long-term potentiation and long-term memory formation, was significantly increased after GTC administration.	Cyclic AMP	37-41	cAMP responsive element binding protein 1	Mus musculus	80-84
19819979-8	2009	Furthermore, PI3K inhibition and DN Akt prevented association of the transcriptional coactivator, CREB (cAMP response element binding protein) binding protein (CBP), with Smads 1/5.	Cyclic AMP	104-108	cAMP responsive element binding protein 1	Mus musculus	98-102
19675537-2	2009	Previously, we have shown that a single exposure to forced swim (FS) reinstates extinguished conditioned place preference (CPP) to cocaine and that cAMP response element binding protein (CREB) is necessary for this response.	Cocaine	131-138	cAMP responsive element binding protein 1	Mus musculus	187-191
19675537-4	2009	The present experiments investigate whether changes in cocaine reward elicited by previous exposure to stress are mediated by CREB and/or CRF(R1).	Cocaine	55-62	cAMP responsive element binding protein 1	Mus musculus	126-130
19675537-7	2009	Furthermore, FS-induced increase in phosphorylated CREB (pCREB), specifically in the lateral septum (LS) and nucleus accumbens (NAc) is also blocked by antalarmin.	phenylalanylserine	13-15	cAMP responsive element binding protein 1	Mus musculus	51-55
19675537-7	2009	Furthermore, FS-induced increase in phosphorylated CREB (pCREB), specifically in the lateral septum (LS) and nucleus accumbens (NAc) is also blocked by antalarmin.	leucylserine	101-103	cAMP responsive element binding protein 1	Mus musculus	51-55
19646972-0	2009	Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation.	nobiletin	0-9	cAMP responsive element binding protein 1	Mus musculus	105-109
19646972-8	2009	The nobiletin treatment prevented the reduction in CaMKII, MAP2 and GluR1 protein levels in the hippocampal CA1 region, accompanied by restoration of both ERK and CREB phosphorylation and CaMKII autophosphorylation.	nobiletin	4-13	cAMP responsive element binding protein 1	Mus musculus	163-167
19812345-0	2009	Autocrine activation of neuronal NMDA receptors by aspartate mediates dopamine- and cAMP-induced CREB-dependent gene transcription.	Dopamine	70-78	cAMP responsive element binding protein 1	Mus musculus	97-101
19812345-0	2009	Autocrine activation of neuronal NMDA receptors by aspartate mediates dopamine- and cAMP-induced CREB-dependent gene transcription.	Cyclic AMP	84-88	cAMP responsive element binding protein 1	Mus musculus	97-101
19812345-1	2009	cAMP can stimulate the transcription of many activity-dependent genes via activation of the transcription factor, cAMP response element-binding protein (CREB).	Cyclic AMP	0-4	cAMP responsive element binding protein 1	Mus musculus	114-151
19812345-1	2009	cAMP can stimulate the transcription of many activity-dependent genes via activation of the transcription factor, cAMP response element-binding protein (CREB).	Cyclic AMP	0-4	cAMP responsive element binding protein 1	Mus musculus	153-157
19812345-4	2009	Aspartate was identified as the extracellular messenger: enzymatic scavenging of l-aspartate, but not glutamate, blocked stimulation of CREB-dependent gene transcription by cAMP; moreover, cAMP induced aspartate but not glutamate release.	Aspartic Acid	0-9	cAMP responsive element binding protein 1	Mus musculus	136-140
19812345-4	2009	Aspartate was identified as the extracellular messenger: enzymatic scavenging of l-aspartate, but not glutamate, blocked stimulation of CREB-dependent gene transcription by cAMP; moreover, cAMP induced aspartate but not glutamate release.	Aspartic Acid	81-92	cAMP responsive element binding protein 1	Mus musculus	136-140
19812345-4	2009	Aspartate was identified as the extracellular messenger: enzymatic scavenging of l-aspartate, but not glutamate, blocked stimulation of CREB-dependent gene transcription by cAMP; moreover, cAMP induced aspartate but not glutamate release.	Cyclic AMP	173-177	cAMP responsive element binding protein 1	Mus musculus	136-140
19812345-4	2009	Aspartate was identified as the extracellular messenger: enzymatic scavenging of l-aspartate, but not glutamate, blocked stimulation of CREB-dependent gene transcription by cAMP; moreover, cAMP induced aspartate but not glutamate release.	Cyclic AMP	189-193	cAMP responsive element binding protein 1	Mus musculus	136-140
19812345-4	2009	Aspartate was identified as the extracellular messenger: enzymatic scavenging of l-aspartate, but not glutamate, blocked stimulation of CREB-dependent gene transcription by cAMP; moreover, cAMP induced aspartate but not glutamate release.	Aspartic Acid	83-92	cAMP responsive element binding protein 1	Mus musculus	136-140
19775283-10	2009	Western blot analysis showed that tanshinone I reversed the diazepam- and MK-801-induced inhibitions of ERK and CREB activation in hippocampal tissues.	tanshinone	34-46	cAMP responsive element binding protein 1	Mus musculus	112-116
19775283-10	2009	Western blot analysis showed that tanshinone I reversed the diazepam- and MK-801-induced inhibitions of ERK and CREB activation in hippocampal tissues.	Diazepam	60-68	cAMP responsive element binding protein 1	Mus musculus	112-116
19775283-10	2009	Western blot analysis showed that tanshinone I reversed the diazepam- and MK-801-induced inhibitions of ERK and CREB activation in hippocampal tissues.	Dizocilpine Maleate	74-80	cAMP responsive element binding protein 1	Mus musculus	112-116
19605502-5	2009	Examination of the molecular mechanism of Gpr48 action in bone formation revealed that Gpr48 can activate the cAMP-PKA-CREB signaling pathway to regulate the expression level of Atf4 in osteoblasts.	Cyclic AMP	110-114	cAMP responsive element binding protein 1	Mus musculus	119-123
19621437-0	2009	Generation of a conditional CREB Ser133Ala knockin mouse.	ser133ala	33-42	cAMP responsive element binding protein 1	Mus musculus	28-32
19621437-3	2009	As CREB knockout is perinatal lethal, a minigene strategy was used to allow conditional knockin of the Ser133Ala mutation in adult mice using Cre recombinase.	ser133ala	103-112	cAMP responsive element binding protein 1	Mus musculus	3-7
19805389-3	2009	In the studies reported here we have asked whether the acute alterations in dendritic spines induced by Abeta, as well as the chronic loss of spine density seen in hAPP transgenic mice, are reversible by treatments that restore the cAMP/PKA/CREB signaling pathway or proteasome function to control levels.	Cyclic AMP	232-236	cAMP responsive element binding protein 1	Mus musculus	241-245
19826619-0	2009	Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses toward morphine--and morphine withdrawal-related cues.	Morphine	123-131	cAMP responsive element binding protein 1	Mus musculus	14-53
19826619-0	2009	Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses toward morphine--and morphine withdrawal-related cues.	Morphine	137-145	cAMP responsive element binding protein 1	Mus musculus	14-53
19826619-1	2009	To investigate the role of cAMP responsive element binding protein (CREB)-dependent gene expression in morphine induced behaviors, we examined bitransgenic mice expressing a dominant and strong inhibitor of the CREB family of transcription factors, A-CREB, in striatal neurons in a regulatable manner.	Morphine	103-111	cAMP responsive element binding protein 1	Mus musculus	68-72
19826619-2	2009	The expression of A-CREB in the striatum enhanced both morphine-induced conditioned place preference and morphine withdrawal-induced conditioned place avoidance.	Morphine	55-63	cAMP responsive element binding protein 1	Mus musculus	20-24
19826619-2	2009	The expression of A-CREB in the striatum enhanced both morphine-induced conditioned place preference and morphine withdrawal-induced conditioned place avoidance.	Morphine	105-113	cAMP responsive element binding protein 1	Mus musculus	20-24
19684611-7	2009	In primary hippocampal neurons, as well as in the hippocampus of maze-trained mice, PGS32 activated the mitogen-activated protein (MAP) kinase cascade by promoting phosphorylation of ERK, CREB and synapsin I.	pgs32	84-89	cAMP responsive element binding protein 1	Mus musculus	188-192
19576939-6	2009	Additionally, phloridzin stimulated cAMP production and phosphorylation of the cAMP-response element binding protein (CREB).	Phlorhizin	14-24	cAMP responsive element binding protein 1	Mus musculus	79-116
19576939-6	2009	Additionally, phloridzin stimulated cAMP production and phosphorylation of the cAMP-response element binding protein (CREB).	Phlorhizin	14-24	cAMP responsive element binding protein 1	Mus musculus	118-122
19447162-3	2009	We found that chronic treatment with sorafenib stimulated PKA and CREB phosphorylation and inhibited cRaf-1 and NF-kappaB in the brains of APPswe mice.	Sorafenib	37-46	cAMP responsive element binding protein 1	Mus musculus	66-70
19826621-4	2009	Here we show, in startling contrast, that inhibition of striatal CREB facilitates cocaine- and morphine-place conditioning and enhances locomotor sensitization to cocaine.	Cocaine	82-89	cAMP responsive element binding protein 1	Mus musculus	65-69
19826621-4	2009	Here we show, in startling contrast, that inhibition of striatal CREB facilitates cocaine- and morphine-place conditioning and enhances locomotor sensitization to cocaine.	Morphine	95-103	cAMP responsive element binding protein 1	Mus musculus	65-69
19826621-4	2009	Here we show, in startling contrast, that inhibition of striatal CREB facilitates cocaine- and morphine-place conditioning and enhances locomotor sensitization to cocaine.	Cocaine	163-170	cAMP responsive element binding protein 1	Mus musculus	65-69
19587094-5	2009	CAY treatment restored papilloma formation in TPA/Indo-treated mice and increased cyclic adenosine 3",5"-monophosphate and PKA activation as measured by p-CREB formation.	cay	0-3	cAMP responsive element binding protein 1	Mus musculus	155-159
19499975-5	2009	Isoproterenol, a strong CREB activator, prominently increased rAAV transduction and the increase was abrogated by silencing the CREB gene with small interfering RNA.	Isoproterenol	0-13	cAMP responsive element binding protein 1	Mus musculus	24-28
19499975-5	2009	Isoproterenol, a strong CREB activator, prominently increased rAAV transduction and the increase was abrogated by silencing the CREB gene with small interfering RNA.	Isoproterenol	0-13	cAMP responsive element binding protein 1	Mus musculus	128-132
19499975-6	2009	In addition, rAAV infection of muscle cells mildly but significantly induced CREB protein phosphorylation at serine-133, and was capable of stimulating CREB-dependent transcription from a reporter plasmid.	Serine	109-115	cAMP responsive element binding protein 1	Mus musculus	77-81
19601643-0	2009	4"-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade.	4'-demethylnobiletin	0-20	cAMP responsive element binding protein 1	Mus musculus	76-80
19601643-0	2009	4"-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade.	nobiletin	11-20	cAMP responsive element binding protein 1	Mus musculus	76-80
19427796-5	2009	This increase was abolished by SB203580 treatment, indicating that p38MAPK may activate CREB.	SB 203580	31-39	cAMP responsive element binding protein 1	Mus musculus	88-92
19491401-8	2009	Forskolin stimulation and C/EBPbeta overexpression in 3T3-L1 cells increased C/EBPbeta and CREB but displaced ATF-2 and CHOP10 binding to the Pgc-1alpha proximal CRE.	Colforsin	0-9	cAMP responsive element binding protein 1	Mus musculus	91-95
19341783-7	2009	Chronic administration of morphine made the expression of RACK1 and CREB mRNA increase in hippocampus and prefrontal cortex.	Morphine	26-34	cAMP responsive element binding protein 1	Mus musculus	68-72
19341783-8	2009	The expression of RACK1 and CREB protein was strongly positive in CA1, CA3 and dentate gyrus (DG) of the hippocampus of morphine-treated mice brain, especially the pyramidal neurons in the DG of the hippocampus.	Morphine	120-128	cAMP responsive element binding protein 1	Mus musculus	28-32
19341783-9	2009	Using the small interfering RNA technology, we determined that the expression of CREB mRNA was decreased in hippocampus and prefrontal cortex of morphine-treated mice.	Morphine	145-153	cAMP responsive element binding protein 1	Mus musculus	81-85
19341783-11	2009	These findings suggest that morphine reward can influence the expression of RACK1 in mouse hippocampus and prefrontal cortex through regulating CREB transcription.	Morphine	28-36	cAMP responsive element binding protein 1	Mus musculus	144-148
19505983-8	2009	Compared to results from sedentary mice, vascular Akt phosphorylation and eNOS phosphorylation at S617 during treadmill-running were prevented by wortmannin but not vehicle treatment, whereas exercise-related increases in AMPK and CREB phosphorylation were similar between groups.	Wortmannin	146-156	cAMP responsive element binding protein 1	Mus musculus	231-235
19508397-10	2009	The colonic expression of COX-2 at 24 h and that of phospho-NF-kappaB and phospho-CREB (peaking at 6 h) after colitis induction were consistently inhibited by both alpha,beta-amyrin and dexamethasone.	beta-amyrin	170-181	cAMP responsive element binding protein 1	Mus musculus	82-86
19508397-11	2009	CONCLUSIONS AND IMPLICATIONS: Systemic administration of alpha,beta-amyrin exerted a marked and rapid inhibition of TNBS-induced colitis, related to the local suppression of inflammatory cytokines and COX-2 levels, possibly via inhibition of NF-kappaB and CREB-signalling pathways.	alpha,beta-amyrin	57-74	cAMP responsive element binding protein 1	Mus musculus	256-260
19212318-0	2009	Nucleus accumbens CREB activity is necessary for nicotine conditioned place preference.	Nicotine	49-57	cAMP responsive element binding protein 1	Mus musculus	18-22
19282384-5	2009	Transcriptional activation of the StAR gene by PMA and (Bu)(2)cAMP was influenced by several factors, its up-regulation being dependent on phosphorylation of the cAMP response element binding protein (CREB).	Cyclic AMP	62-66	cAMP responsive element binding protein 1	Mus musculus	162-199
19282384-5	2009	Transcriptional activation of the StAR gene by PMA and (Bu)(2)cAMP was influenced by several factors, its up-regulation being dependent on phosphorylation of the cAMP response element binding protein (CREB).	Cyclic AMP	62-66	cAMP responsive element binding protein 1	Mus musculus	201-205
19282384-6	2009	An oligonucleotide probe containing a CREB/activating transcription factor binding region in the StAR promoter was found to bind nuclear proteins in PMA and (Bu)(2)cAMP-treated MA-10 and KK-1 cells.	Oligonucleotides	3-18	cAMP responsive element binding protein 1	Mus musculus	38-42
19282384-6	2009	An oligonucleotide probe containing a CREB/activating transcription factor binding region in the StAR promoter was found to bind nuclear proteins in PMA and (Bu)(2)cAMP-treated MA-10 and KK-1 cells.	Cyclic AMP	164-168	cAMP responsive element binding protein 1	Mus musculus	38-42
19212318-3	2009	Previous studies have implicated nucleus accumbens (NAc) CREB activity in the modulation of cocaine and morphine reward, and have shown that nicotine conditioned place preference (CPP) is associated with NAc CREB activation.	Cocaine	92-99	cAMP responsive element binding protein 1	Mus musculus	57-61
19212318-3	2009	Previous studies have implicated nucleus accumbens (NAc) CREB activity in the modulation of cocaine and morphine reward, and have shown that nicotine conditioned place preference (CPP) is associated with NAc CREB activation.	Morphine	104-112	cAMP responsive element binding protein 1	Mus musculus	57-61
19212318-3	2009	Previous studies have implicated nucleus accumbens (NAc) CREB activity in the modulation of cocaine and morphine reward, and have shown that nicotine conditioned place preference (CPP) is associated with NAc CREB activation.	Nicotine	141-149	cAMP responsive element binding protein 1	Mus musculus	57-61
19212318-3	2009	Previous studies have implicated nucleus accumbens (NAc) CREB activity in the modulation of cocaine and morphine reward, and have shown that nicotine conditioned place preference (CPP) is associated with NAc CREB activation.	Nicotine	141-149	cAMP responsive element binding protein 1	Mus musculus	208-212
19212318-8	2009	Taken together, these studies identify the NAc shell as a brain region where CREB activity is essential for nicotine CPP.	Nicotine	108-116	cAMP responsive element binding protein 1	Mus musculus	77-81
19553447-2	2009	Downregulation of the nitric oxide/cGMP/cGMP-dependent protein kinase/c-AMP responsive element-binding protein (CREB) cascade has been linked to the synaptic deficits after A beta elevation.	Cyclic GMP	35-39	cAMP responsive element binding protein 1	Mus musculus	63-110
19553447-2	2009	Downregulation of the nitric oxide/cGMP/cGMP-dependent protein kinase/c-AMP responsive element-binding protein (CREB) cascade has been linked to the synaptic deficits after A beta elevation.	Cyclic GMP	35-39	cAMP responsive element binding protein 1	Mus musculus	112-116
19553447-2	2009	Downregulation of the nitric oxide/cGMP/cGMP-dependent protein kinase/c-AMP responsive element-binding protein (CREB) cascade has been linked to the synaptic deficits after A beta elevation.	Nitric Oxide	22-34	cAMP responsive element binding protein 1	Mus musculus	63-110
19553447-2	2009	Downregulation of the nitric oxide/cGMP/cGMP-dependent protein kinase/c-AMP responsive element-binding protein (CREB) cascade has been linked to the synaptic deficits after A beta elevation.	Nitric Oxide	22-34	cAMP responsive element binding protein 1	Mus musculus	112-116
19553447-2	2009	Downregulation of the nitric oxide/cGMP/cGMP-dependent protein kinase/c-AMP responsive element-binding protein (CREB) cascade has been linked to the synaptic deficits after A beta elevation.	Cyclic GMP	40-44	cAMP responsive element binding protein 1	Mus musculus	63-110
19553447-2	2009	Downregulation of the nitric oxide/cGMP/cGMP-dependent protein kinase/c-AMP responsive element-binding protein (CREB) cascade has been linked to the synaptic deficits after A beta elevation.	Cyclic GMP	40-44	cAMP responsive element binding protein 1	Mus musculus	112-116
19553447-3	2009	Here, we report that the phosphodiesterase 5 inhibitor (PDE5) sildenafil (Viagra), a molecule that enhances phosphorylation of CREB, a molecule involved in memory, through elevation of cGMP levels, is beneficial against the AD phenotype in a mouse model of amyloid deposition.	Sildenafil Citrate	62-72	cAMP responsive element binding protein 1	Mus musculus	127-131
19553447-3	2009	Here, we report that the phosphodiesterase 5 inhibitor (PDE5) sildenafil (Viagra), a molecule that enhances phosphorylation of CREB, a molecule involved in memory, through elevation of cGMP levels, is beneficial against the AD phenotype in a mouse model of amyloid deposition.	Sildenafil Citrate	74-80	cAMP responsive element binding protein 1	Mus musculus	127-131
19553447-3	2009	Here, we report that the phosphodiesterase 5 inhibitor (PDE5) sildenafil (Viagra), a molecule that enhances phosphorylation of CREB, a molecule involved in memory, through elevation of cGMP levels, is beneficial against the AD phenotype in a mouse model of amyloid deposition.	Cyclic GMP	185-189	cAMP responsive element binding protein 1	Mus musculus	127-131
19447090-3	2009	Our findings reveal several interesting principles of gene regulation by cocaine and of the role of DeltaFosB and CREB, two prominent cocaine-induced transcription factors, in this brain region.	Cocaine	134-141	cAMP responsive element binding protein 1	Mus musculus	114-118
19490902-2	2009	(2009) shows how metformin circumvents a block between insulin and atypical protein kinase C in obese and diabetic mice to inhibit gluconeogenesis by stimulating the phosphorylation of CBP and the disassembly of the CREB transcriptional complex.	Metformin	17-26	cAMP responsive element binding protein 1	Mus musculus	216-220
19535594-4	2009	Our results demonstrate that chronic defeat stress causes widespread and long-lasting changes in gene regulation, including alterations in repressive histone methylation and in phospho-CREB (cAMP response element-binding protein) binding, in the NAc.	Cyclic AMP	191-195	cAMP responsive element binding protein 1	Mus musculus	185-189
19523204-5	2009	Intrathecal pretreatment of MK-801 or EphB2-Fc prevented LTP and significantly reduced upregulation of p-CaMKII, p-ERK, p-CREB and c-Fos.	Dizocilpine Maleate	28-34	cAMP responsive element binding protein 1	Mus musculus	122-126
19031446-2	2009	The effect, if any, of these Ca(2+) waves on the transcription of Ca(2+)/cAMP-regulatory element binding protein (CREB)-dependent genes is not known.	Cyclic AMP	73-77	cAMP responsive element binding protein 1	Mus musculus	114-118
19031446-4	2009	In contrast, both CREB phosphorylation and CREB-dependent transcription were robustly stimulated by increasing cAMP.	Cyclic AMP	111-115	cAMP responsive element binding protein 1	Mus musculus	18-22
19031446-4	2009	In contrast, both CREB phosphorylation and CREB-dependent transcription were robustly stimulated by increasing cAMP.	Cyclic AMP	111-115	cAMP responsive element binding protein 1	Mus musculus	43-47
19289113-8	2009	The results suggest potential links between the morphine-induced alteration of aldolase C and the regulation of CREB phosphorylation, a possible mechanism of morphine dependence.	Morphine	48-56	cAMP responsive element binding protein 1	Mus musculus	112-116
19279000-6	2009	Additionally, modification of histone H3 increased its association with the transcription factor, phosphorylated cAMP-response element-binding protein (phospho-CREB) and with cAMP-responsive CREB coactivator 2.	Cyclic AMP	113-117	cAMP responsive element binding protein 1	Mus musculus	160-164
19279000-6	2009	Additionally, modification of histone H3 increased its association with the transcription factor, phosphorylated cAMP-response element-binding protein (phospho-CREB) and with cAMP-responsive CREB coactivator 2.	Cyclic AMP	175-179	cAMP responsive element binding protein 1	Mus musculus	160-164
19279000-6	2009	Additionally, modification of histone H3 increased its association with the transcription factor, phosphorylated cAMP-response element-binding protein (phospho-CREB) and with cAMP-responsive CREB coactivator 2.	Cyclic AMP	175-179	cAMP responsive element binding protein 1	Mus musculus	191-195
19289113-0	2009	Chronic morphine administration induces over-expression of aldolase C with reduction of CREB phosphorylation in the mouse hippocampus.	Morphine	8-16	cAMP responsive element binding protein 1	Mus musculus	88-92
19289113-8	2009	The results suggest potential links between the morphine-induced alteration of aldolase C and the regulation of CREB phosphorylation, a possible mechanism of morphine dependence.	Morphine	158-166	cAMP responsive element binding protein 1	Mus musculus	112-116
19289113-5	2009	Naloxone pretreatment before morphine administration suppressed withdrawal jumping, weight loss, and overexpression of aldolase C. CREB is a transcription factor regulated through phosphorylation on Ser133, which is known to play a key role in the mechanism of morphine dependence.	Naloxone	0-8	cAMP responsive element binding protein 1	Mus musculus	131-135
19289113-5	2009	Naloxone pretreatment before morphine administration suppressed withdrawal jumping, weight loss, and overexpression of aldolase C. CREB is a transcription factor regulated through phosphorylation on Ser133, which is known to play a key role in the mechanism of morphine dependence.	Morphine	29-37	cAMP responsive element binding protein 1	Mus musculus	131-135
19289113-5	2009	Naloxone pretreatment before morphine administration suppressed withdrawal jumping, weight loss, and overexpression of aldolase C. CREB is a transcription factor regulated through phosphorylation on Ser133, which is known to play a key role in the mechanism of morphine dependence.	Morphine	261-269	cAMP responsive element binding protein 1	Mus musculus	131-135
19289113-6	2009	When detecting the expression of phosphorylated CREB (p-CREB) in the mouse hippocampus using Western blot and immunohistochemistry, we found CREB phosphorylation was clearly decreased following chronic morphine treatment.	Morphine	202-210	cAMP responsive element binding protein 1	Mus musculus	48-52
18602807-4	2009	Incubation with DON induced IL-6 expression in naive macrophages maximally at 3 h. Knockdown of the transcription factor cAMP response element-binding protein (CREB) or pharmacologic inhibition of the CREB kinases Akt1/2, MSK1 and RSK1 down-regulated this expression.	deoxynivalenol	16-19	cAMP responsive element binding protein 1	Mus musculus	121-158
19289113-6	2009	When detecting the expression of phosphorylated CREB (p-CREB) in the mouse hippocampus using Western blot and immunohistochemistry, we found CREB phosphorylation was clearly decreased following chronic morphine treatment.	Morphine	202-210	cAMP responsive element binding protein 1	Mus musculus	56-60
19289113-6	2009	When detecting the expression of phosphorylated CREB (p-CREB) in the mouse hippocampus using Western blot and immunohistochemistry, we found CREB phosphorylation was clearly decreased following chronic morphine treatment.	Morphine	202-210	cAMP responsive element binding protein 1	Mus musculus	56-60
18602807-4	2009	Incubation with DON induced IL-6 expression in naive macrophages maximally at 3 h. Knockdown of the transcription factor cAMP response element-binding protein (CREB) or pharmacologic inhibition of the CREB kinases Akt1/2, MSK1 and RSK1 down-regulated this expression.	deoxynivalenol	16-19	cAMP responsive element binding protein 1	Mus musculus	160-164
18602807-4	2009	Incubation with DON induced IL-6 expression in naive macrophages maximally at 3 h. Knockdown of the transcription factor cAMP response element-binding protein (CREB) or pharmacologic inhibition of the CREB kinases Akt1/2, MSK1 and RSK1 down-regulated this expression.	deoxynivalenol	16-19	cAMP responsive element binding protein 1	Mus musculus	201-205
18602807-6	2009	Phosphorylations of PKR, CREB kinases and CREB were markedly impaired in peritoneal macrophages isolated from mice that consumed DHA-enriched fish oil for 6 to 8 weeks.	Docosahexaenoic Acids	129-132	cAMP responsive element binding protein 1	Mus musculus	25-29
18602807-6	2009	Phosphorylations of PKR, CREB kinases and CREB were markedly impaired in peritoneal macrophages isolated from mice that consumed DHA-enriched fish oil for 6 to 8 weeks.	Docosahexaenoic Acids	129-132	cAMP responsive element binding protein 1	Mus musculus	42-46
18602807-10	2009	These data suggest that DON-induced IL-6 expression is CREB mediated and PKR dependent, and that requisite kinase activities for these pathways were suppressed in macrophages from mice fed DHA for an extended period.	deoxynivalenol	24-27	cAMP responsive element binding protein 1	Mus musculus	55-59
18602807-10	2009	These data suggest that DON-induced IL-6 expression is CREB mediated and PKR dependent, and that requisite kinase activities for these pathways were suppressed in macrophages from mice fed DHA for an extended period.	Docosahexaenoic Acids	189-192	cAMP responsive element binding protein 1	Mus musculus	55-59
19233146-10	2009	Taken together, in addition to CaMKII, CaMKI and CaMKIV activation mediated by nefiracetam treatment might mediate CREB phosphorylation following chronic nefiracetam treatment, thereby eliciting an anti-depressive and cognition-enhancing effect on OBX mice.	nefiracetam	79-90	cAMP responsive element binding protein 1	Mus musculus	115-119
19435810-1	2009	We used a double transgenic tetracycline system to conditionally express A-CREB, a dominant negative protein that prevents the DNA binding and function of cAMP-responsive element binding protein (CREB) family members, in mouse basal epidermis using the keratin 5 promoter.	Tetracycline	28-40	cAMP responsive element binding protein 1	Mus musculus	75-79
19435810-3	2009	However, following a 7,12-dimethylbenz(a)anthracene (DMBA)/phorbol-12-myristate-13-acetate two-stage skin carcinogenesis experiment, A-CREB-expressing epidermis develop 5-fold fewer papillomas than wild-type controls.	7,12-dimethylbenz	21-38	cAMP responsive element binding protein 1	Mus musculus	135-139
19435810-3	2009	However, following a 7,12-dimethylbenz(a)anthracene (DMBA)/phorbol-12-myristate-13-acetate two-stage skin carcinogenesis experiment, A-CREB-expressing epidermis develop 5-fold fewer papillomas than wild-type controls.	Tetradecanoylphorbol Acetate	59-90	cAMP responsive element binding protein 1	Mus musculus	135-139
19332462-9	2009	In addition, the ALDH2 transgene significantly attenuated chronic alcohol intake-induced myocardial fibrosis, protein carbonyl formation, apoptosis, enhanced NADPH oxidase p47(phox) and calcineurin expression, as well as phosphorylation of ASK-1, GSK-3beta, GATA4, and CREB.	Alcohols	66-73	cAMP responsive element binding protein 1	Mus musculus	269-273
19332462-10	2009	CONCLUSIONS: The present results suggest that transgenic overexpression of ALDH2 effectively antagonizes chronic alcohol intake-elicited myocardial hypertrophy and contractile defect through a mechanism that is associated, at least in part, with phosphorylation of ASK-1, GSK-3beta, GATA4, and CREB.	Alcohols	113-120	cAMP responsive element binding protein 1	Mus musculus	294-298
19233146-10	2009	Taken together, in addition to CaMKII, CaMKI and CaMKIV activation mediated by nefiracetam treatment might mediate CREB phosphorylation following chronic nefiracetam treatment, thereby eliciting an anti-depressive and cognition-enhancing effect on OBX mice.	nefiracetam	154-165	cAMP responsive element binding protein 1	Mus musculus	115-119
19189864-5	2009	The DNA-binding and specific reporter activity of cAMP response element-binding transcription factor (CREB), which is one of the key molecules regulating BDNF expression, were reduced by 1-BP in U251 and/or mouse primary astrocytes.	Cyclic AMP	50-54	cAMP responsive element binding protein 1	Mus musculus	102-106
19409206-7	2009	These results demonstrated that long-term 0.05% or 0.1% green tea catechin administration may prevent age-related spatial learning and memory decline of female C57BL/6 J mice by regulating hippocampal CREB signaling cascade.	Catechin	66-74	cAMP responsive element binding protein 1	Mus musculus	201-205
19248161-10	2009	TFA administration also attenuated PSD-induced neuronal death/losses, upregulated expression of BDNF both at mRNA and protein levels, as well as CREB mRNA levels.	Trifluoroacetic Acid	0-3	cAMP responsive element binding protein 1	Mus musculus	145-149
19401163-7	2009	Western blot analyses showed altered expressions of various cellular factors, such as up-regulation of transthyretin, phospho-ERK, and phospho-CREB in the brain treated with SK-PC-B70M.	sk-pc	174-179	cAMP responsive element binding protein 1	Mus musculus	143-147
18923397-5	2009	Meanwhile, AQP4 knockout abolished fluoxetine-induced enhancement of hippocampal cyclic AMP-responsive element binding protein (CREB) phosphorylation.	Fluoxetine	35-45	cAMP responsive element binding protein 1	Mus musculus	81-126
18923397-5	2009	Meanwhile, AQP4 knockout abolished fluoxetine-induced enhancement of hippocampal cyclic AMP-responsive element binding protein (CREB) phosphorylation.	Fluoxetine	35-45	cAMP responsive element binding protein 1	Mus musculus	128-132
19298258-8	2009	In addition, the inhibitory effect of torilin on NF-kappaB and CREB was shown by torilin-mediated recovery of LPS-induced degradation of inhibitor kappaB-alpha and suppression of LPS-induced phosphorylation of CREB respectively.	torilin	38-45	cAMP responsive element binding protein 1	Mus musculus	63-67
19298258-8	2009	In addition, the inhibitory effect of torilin on NF-kappaB and CREB was shown by torilin-mediated recovery of LPS-induced degradation of inhibitor kappaB-alpha and suppression of LPS-induced phosphorylation of CREB respectively.	torilin	38-45	cAMP responsive element binding protein 1	Mus musculus	210-214
19252502-3	2009	We found that the transcription of Ppargc1b, which encodes peroxisome proliferator-activated receptor-gamma coactivator 1beta (PGC-1beta), was induced during osteoclast differentiation by cAMP response element-binding protein (CREB) as a result of reactive oxygen species.	Reactive Oxygen Species	248-271	cAMP responsive element binding protein 1	Mus musculus	188-225
19141071-7	2009	Finally, the neuroprotective effect of brain-derived neurotrophic factor (BDNF) against ROS-mediated cell death was abrogated by disruption of CREB-mediated transcription.	Reactive Oxygen Species	88-91	cAMP responsive element binding protein 1	Mus musculus	143-147
19141071-8	2009	Together, these data both extend our understanding of CREB functionality and provide in vivo validation for a model in which CREB functions as a pivotal upstream integrator of neuroprotective signaling against ROS-mediated cell death.	Reactive Oxygen Species	210-213	cAMP responsive element binding protein 1	Mus musculus	54-58
19141071-8	2009	Together, these data both extend our understanding of CREB functionality and provide in vivo validation for a model in which CREB functions as a pivotal upstream integrator of neuroprotective signaling against ROS-mediated cell death.	Reactive Oxygen Species	210-213	cAMP responsive element binding protein 1	Mus musculus	125-129
19141071-3	2009	Here, we employed a transgenic approach in which cAMP-response element binding protein (CREB)-mediated transcription is repressed (via A-CREB) to examine the contribution of the CREB/cAMP response element pathway to neuroprotection and its potential role in limiting ROS toxicity.	Cyclic AMP	49-53	cAMP responsive element binding protein 1	Mus musculus	88-92
19141071-4	2009	Using the pilocarpine-evoked repetitive seizure model, we detected a marked enhancement of cell death in A-CREB transgenic mice.	Pilocarpine	10-21	cAMP responsive element binding protein 1	Mus musculus	107-111
19141071-5	2009	Paralleling this, there was a dramatic increase in tyrosine nitration (a marker of reactive species formation) in A-CREB transgenic mice.	Tyrosine	51-59	cAMP responsive element binding protein 1	Mus musculus	116-120
19181855-4	2009	Compared with WT mice, tPA-/- mice injected with cocaine displayed attenuated phosphorylation of ERK, cAMP response element binding protein (CREB), and dopamine and cAMP-regulated phosphoprotein 32 kDa (DARPP-32) and blunted induction of immediate early genes (IEGs) c-Fos, Egr-1, and Homer 1a in the amygdala and the nucleus accumbens (NAc).	Cocaine	49-56	cAMP responsive element binding protein 1	Mus musculus	102-139
19244515-10	2009	Our results demonstrate that the Ca(2+)-stimulated adenylyl cyclases regulate long-lasting cocaine-induced behavioral plasticity via activation of the ERK/MSK1/CREB signaling pathway in striatonigral MSNs.	Cocaine	91-98	cAMP responsive element binding protein 1	Mus musculus	160-164
19211892-6	2009	However, mCREB-expressing mice were more sensitive to the rewarding (threshold-lowering) effects of cocaine.	Cocaine	100-107	cAMP responsive element binding protein 1	Mus musculus	9-14
19181855-4	2009	Compared with WT mice, tPA-/- mice injected with cocaine displayed attenuated phosphorylation of ERK, cAMP response element binding protein (CREB), and dopamine and cAMP-regulated phosphoprotein 32 kDa (DARPP-32) and blunted induction of immediate early genes (IEGs) c-Fos, Egr-1, and Homer 1a in the amygdala and the nucleus accumbens (NAc).	Cocaine	49-56	cAMP responsive element binding protein 1	Mus musculus	141-145
18814142-4	2009	Exposure to adrenaline not only increased cAMP formation, phosphorylation of cAMP responsive element (CRE) binding protein (CREB) on serine133 and CRE reporter activity in a manner sensitive to propranolol, but also rendered C3H10T1/2 cells resistant to the cytotoxicity of hydrogen peroxide, but not of either 2,4-dinitirophenol or tunicamycin.	Epinephrine	12-22	cAMP responsive element binding protein 1	Mus musculus	124-128
18814142-4	2009	Exposure to adrenaline not only increased cAMP formation, phosphorylation of cAMP responsive element (CRE) binding protein (CREB) on serine133 and CRE reporter activity in a manner sensitive to propranolol, but also rendered C3H10T1/2 cells resistant to the cytotoxicity of hydrogen peroxide, but not of either 2,4-dinitirophenol or tunicamycin.	Cyclic AMP	42-46	cAMP responsive element binding protein 1	Mus musculus	124-128
18814142-4	2009	Exposure to adrenaline not only increased cAMP formation, phosphorylation of cAMP responsive element (CRE) binding protein (CREB) on serine133 and CRE reporter activity in a manner sensitive to propranolol, but also rendered C3H10T1/2 cells resistant to the cytotoxicity of hydrogen peroxide, but not of either 2,4-dinitirophenol or tunicamycin.	Cyclic AMP	77-81	cAMP responsive element binding protein 1	Mus musculus	124-128
18814142-4	2009	Exposure to adrenaline not only increased cAMP formation, phosphorylation of cAMP responsive element (CRE) binding protein (CREB) on serine133 and CRE reporter activity in a manner sensitive to propranolol, but also rendered C3H10T1/2 cells resistant to the cytotoxicity of hydrogen peroxide, but not of either 2,4-dinitirophenol or tunicamycin.	serine133	133-142	cAMP responsive element binding protein 1	Mus musculus	124-128
18814142-4	2009	Exposure to adrenaline not only increased cAMP formation, phosphorylation of cAMP responsive element (CRE) binding protein (CREB) on serine133 and CRE reporter activity in a manner sensitive to propranolol, but also rendered C3H10T1/2 cells resistant to the cytotoxicity of hydrogen peroxide, but not of either 2,4-dinitirophenol or tunicamycin.	Propranolol	194-205	cAMP responsive element binding protein 1	Mus musculus	124-128
18814142-4	2009	Exposure to adrenaline not only increased cAMP formation, phosphorylation of cAMP responsive element (CRE) binding protein (CREB) on serine133 and CRE reporter activity in a manner sensitive to propranolol, but also rendered C3H10T1/2 cells resistant to the cytotoxicity of hydrogen peroxide, but not of either 2,4-dinitirophenol or tunicamycin.	Hydrogen Peroxide	274-291	cAMP responsive element binding protein 1	Mus musculus	124-128
18814142-4	2009	Exposure to adrenaline not only increased cAMP formation, phosphorylation of cAMP responsive element (CRE) binding protein (CREB) on serine133 and CRE reporter activity in a manner sensitive to propranolol, but also rendered C3H10T1/2 cells resistant to the cytotoxicity of hydrogen peroxide, but not of either 2,4-dinitirophenol or tunicamycin.	2,4-dinitirophenol	311-329	cAMP responsive element binding protein 1	Mus musculus	124-128
18814142-4	2009	Exposure to adrenaline not only increased cAMP formation, phosphorylation of cAMP responsive element (CRE) binding protein (CREB) on serine133 and CRE reporter activity in a manner sensitive to propranolol, but also rendered C3H10T1/2 cells resistant to the cytotoxicity of hydrogen peroxide, but not of either 2,4-dinitirophenol or tunicamycin.	Tunicamycin	333-344	cAMP responsive element binding protein 1	Mus musculus	124-128
18783846-10	2009	Lentiviral-mediated expression of dominant-negative mutants of Elk-1 or CREB interfered with glucose-, tolbutamide- and KCl-induced upregulation of Egr-1 biosynthesis.	Potassium Chloride	120-123	cAMP responsive element binding protein 1	Mus musculus	72-76
19228458-5	2009	RESULTS: Acute cocaine injection significantly enhanced expressions of c-Fos, p-CREB and p-Elk-1 in the striatum.	Cocaine	15-22	cAMP responsive element binding protein 1	Mus musculus	80-84
19228458-8	2009	Blockade of this dopamine D1 receptor-dependent ERK1/2 activation by SL 327 could reduce cocaine-enhanced expressions of c-Fos, p-CREB and p-Elk-1 in the striatum.	Cocaine	89-96	cAMP responsive element binding protein 1	Mus musculus	130-134
19960054-6	2009	Additional research from other groups has shown that the expression of the cAMP early inducible repressor (ICER), a CREB repressor, is also deregulated in leukemias.	Cyclic AMP	75-79	cAMP responsive element binding protein 1	Mus musculus	116-120
18783846-0	2009	Calcium influx into MIN6 insulinoma cells induces expression of Egr-1 involving extracellular signal-regulated protein kinase and the transcription factors Elk-1 and CREB.	Calcium	0-7	cAMP responsive element binding protein 1	Mus musculus	166-170
19059431-8	2009	In the granule somata, Amph probably inhibits expression of GAD67 by decreasing phosphorylation of CREB (pCREB).	Amphetamine	23-27	cAMP responsive element binding protein 1	Mus musculus	99-103
18783846-8	2009	Stimulation of beta-cells by glucose, tolbutamide and KCl induced the phosphorylation of the transcription factors Elk-1 and CREB.	Glucose	29-36	cAMP responsive element binding protein 1	Mus musculus	125-129
18783846-8	2009	Stimulation of beta-cells by glucose, tolbutamide and KCl induced the phosphorylation of the transcription factors Elk-1 and CREB.	Tolbutamide	38-49	cAMP responsive element binding protein 1	Mus musculus	125-129
18783846-8	2009	Stimulation of beta-cells by glucose, tolbutamide and KCl induced the phosphorylation of the transcription factors Elk-1 and CREB.	Potassium Chloride	54-57	cAMP responsive element binding protein 1	Mus musculus	125-129
18783846-10	2009	Lentiviral-mediated expression of dominant-negative mutants of Elk-1 or CREB interfered with glucose-, tolbutamide- and KCl-induced upregulation of Egr-1 biosynthesis.	Glucose	93-100	cAMP responsive element binding protein 1	Mus musculus	72-76
18783846-10	2009	Lentiviral-mediated expression of dominant-negative mutants of Elk-1 or CREB interfered with glucose-, tolbutamide- and KCl-induced upregulation of Egr-1 biosynthesis.	Tolbutamide	103-114	cAMP responsive element binding protein 1	Mus musculus	72-76
19661619-6	2009	Bilobalide and quercetin also enhanced phosphorylation of cyclic-AMP Response Element Binding Protein (CREB) in these cells, and elevated the levels of pCREB and, brain-derived neurotrophic factor in mice brain.	bilobalide	0-10	cAMP responsive element binding protein 1	Mus musculus	58-101
19661619-6	2009	Bilobalide and quercetin also enhanced phosphorylation of cyclic-AMP Response Element Binding Protein (CREB) in these cells, and elevated the levels of pCREB and, brain-derived neurotrophic factor in mice brain.	bilobalide	0-10	cAMP responsive element binding protein 1	Mus musculus	103-107
19661619-6	2009	Bilobalide and quercetin also enhanced phosphorylation of cyclic-AMP Response Element Binding Protein (CREB) in these cells, and elevated the levels of pCREB and, brain-derived neurotrophic factor in mice brain.	Quercetin	15-24	cAMP responsive element binding protein 1	Mus musculus	58-101
19661619-6	2009	Bilobalide and quercetin also enhanced phosphorylation of cyclic-AMP Response Element Binding Protein (CREB) in these cells, and elevated the levels of pCREB and, brain-derived neurotrophic factor in mice brain.	Quercetin	15-24	cAMP responsive element binding protein 1	Mus musculus	103-107
19661619-9	2009	The present findings suggest that enhanced neurogenesis and synaptogenesis by bilobalide and quercetin may share a common final signaling pathway mediated by phosphorylation of CREB.	bilobalide	78-88	cAMP responsive element binding protein 1	Mus musculus	177-181
19661619-9	2009	The present findings suggest that enhanced neurogenesis and synaptogenesis by bilobalide and quercetin may share a common final signaling pathway mediated by phosphorylation of CREB.	Quercetin	93-102	cAMP responsive element binding protein 1	Mus musculus	177-181
18848971-0	2008	Additive effects of histone deacetylase inhibitors and amphetamine on histone H4 acetylation, cAMP responsive element binding protein phosphorylation and DeltaFosB expression in the striatum and locomotor sensitization in mice.	Amphetamine	55-66	cAMP responsive element binding protein 1	Mus musculus	94-133
18848971-5	2008	Furthermore, co-administration of BA or VPA with amphetamine produced additive effects on histone H4 acetylation as well as CREB phosphorylation in the striatum.	Butyric Acid	34-36	cAMP responsive element binding protein 1	Mus musculus	124-128
18848971-4	2008	Conversely, repeated treatment with BA or VPA produced amphetamine-like effects: enhanced cAMP responsive element binding protein (CREB) phosphorylation at Ser(133) position and increased DeltaFosB protein levels in the striatum.	Butyric Acid	36-38	cAMP responsive element binding protein 1	Mus musculus	90-129
18848971-5	2008	Furthermore, co-administration of BA or VPA with amphetamine produced additive effects on histone H4 acetylation as well as CREB phosphorylation in the striatum.	Valproic Acid	40-43	cAMP responsive element binding protein 1	Mus musculus	124-128
18848971-4	2008	Conversely, repeated treatment with BA or VPA produced amphetamine-like effects: enhanced cAMP responsive element binding protein (CREB) phosphorylation at Ser(133) position and increased DeltaFosB protein levels in the striatum.	Butyric Acid	36-38	cAMP responsive element binding protein 1	Mus musculus	131-135
18848971-5	2008	Furthermore, co-administration of BA or VPA with amphetamine produced additive effects on histone H4 acetylation as well as CREB phosphorylation in the striatum.	Amphetamine	49-60	cAMP responsive element binding protein 1	Mus musculus	124-128
18848971-4	2008	Conversely, repeated treatment with BA or VPA produced amphetamine-like effects: enhanced cAMP responsive element binding protein (CREB) phosphorylation at Ser(133) position and increased DeltaFosB protein levels in the striatum.	Valproic Acid	42-45	cAMP responsive element binding protein 1	Mus musculus	90-129
18848971-7	2008	Finally, the additive effect of VPA/BA and amphetamine on histone H4 acetylation, phosphorylated CREB, and DeltaFosB was associated with potentiated amphetamine-induced locomotor activity.	Valproic Acid	32-35	cAMP responsive element binding protein 1	Mus musculus	97-101
18848971-4	2008	Conversely, repeated treatment with BA or VPA produced amphetamine-like effects: enhanced cAMP responsive element binding protein (CREB) phosphorylation at Ser(133) position and increased DeltaFosB protein levels in the striatum.	Valproic Acid	42-45	cAMP responsive element binding protein 1	Mus musculus	131-135
18848971-7	2008	Finally, the additive effect of VPA/BA and amphetamine on histone H4 acetylation, phosphorylated CREB, and DeltaFosB was associated with potentiated amphetamine-induced locomotor activity.	Butyric Acid	36-38	cAMP responsive element binding protein 1	Mus musculus	97-101
18848971-4	2008	Conversely, repeated treatment with BA or VPA produced amphetamine-like effects: enhanced cAMP responsive element binding protein (CREB) phosphorylation at Ser(133) position and increased DeltaFosB protein levels in the striatum.	Amphetamine	55-66	cAMP responsive element binding protein 1	Mus musculus	90-129
18848971-7	2008	Finally, the additive effect of VPA/BA and amphetamine on histone H4 acetylation, phosphorylated CREB, and DeltaFosB was associated with potentiated amphetamine-induced locomotor activity.	Amphetamine	43-54	cAMP responsive element binding protein 1	Mus musculus	97-101
18848971-4	2008	Conversely, repeated treatment with BA or VPA produced amphetamine-like effects: enhanced cAMP responsive element binding protein (CREB) phosphorylation at Ser(133) position and increased DeltaFosB protein levels in the striatum.	Serine	156-159	cAMP responsive element binding protein 1	Mus musculus	90-129
18848971-4	2008	Conversely, repeated treatment with BA or VPA produced amphetamine-like effects: enhanced cAMP responsive element binding protein (CREB) phosphorylation at Ser(133) position and increased DeltaFosB protein levels in the striatum.	Serine	156-159	cAMP responsive element binding protein 1	Mus musculus	131-135
18784739-1	2008	The inducible cyclic AMP (cAMP) early repressor (ICER) and cAMP response element-binding protein (CREB) are transcriptional regulators of the cAMP-mediated signaling pathway.	Cyclic AMP	14-24	cAMP responsive element binding protein 1	Mus musculus	98-102
18784739-1	2008	The inducible cyclic AMP (cAMP) early repressor (ICER) and cAMP response element-binding protein (CREB) are transcriptional regulators of the cAMP-mediated signaling pathway.	Cyclic AMP	59-63	cAMP responsive element binding protein 1	Mus musculus	98-102
18299998-0	2008	Expression of phosphorylated cAMP response element binding protein (p-CREB) in bladder afferent pathways in VIP-/- mice with cyclophosphamide (CYP)-induced cystitis.	Cyclic AMP	29-33	cAMP responsive element binding protein 1	Mus musculus	70-74
19041748-6	2008	Serotonin acts on osteoblasts through the Htr1b receptor and CREB to inhibit their proliferation.	Serotonin	0-9	cAMP responsive element binding protein 1	Mus musculus	61-65
18299998-0	2008	Expression of phosphorylated cAMP response element binding protein (p-CREB) in bladder afferent pathways in VIP-/- mice with cyclophosphamide (CYP)-induced cystitis.	Cyclophosphamide	125-141	cAMP responsive element binding protein 1	Mus musculus	70-74
18299998-0	2008	Expression of phosphorylated cAMP response element binding protein (p-CREB) in bladder afferent pathways in VIP-/- mice with cyclophosphamide (CYP)-induced cystitis.	Cyclophosphamide	143-146	cAMP responsive element binding protein 1	Mus musculus	70-74
18299998-1	2008	The expression of phosphorylated cAMP response element binding protein (p-CREB) in dorsal root ganglia (DRG) with and without cyclophosphamide (CYP)-induced cystitis (150 mg/kg, i.p; 48 h) was determined in VIP(-/-) and wild-type (WT) mice.	Cyclic AMP	33-37	cAMP responsive element binding protein 1	Mus musculus	74-78
18810352-3	2008	Objective was to test whether cAMP-induced differentiation in a murine neuroblastoma cell line (NBP2) is partly mediated by CREB.	Cyclic AMP	30-34	cAMP responsive element binding protein 1	Mus musculus	124-128
18810352-5	2008	Real time PCR (RT-PCR) was performed to verify changes in the expression of cAMP/CREB responsive genes.	Cyclic AMP	76-80	cAMP responsive element binding protein 1	Mus musculus	81-85
18508907-0	2008	Small mouse cholangiocytes proliferate in response to H1 histamine receptor stimulation by activation of the IP3/CaMK I/CREB pathway.	Inositol 1,4,5-Trisphosphate	109-112	cAMP responsive element binding protein 1	Mus musculus	120-124
18775326-1	2008	Cyclic AMP-induced phosphorylation of the transcription factor CREB elicits expression of genes mediating diverse biological functions.	Cyclic AMP	0-10	cAMP responsive element binding protein 1	Mus musculus	63-67
18775326-2	2008	In lymphoid organs, the neurotransmitter norepinephrine stimulates beta(2)-adrenergic receptors on B lymphocytes to promote CREB-dependent expression of genes like the B cell Oct 2 coactivator (OCA-B).	Norepinephrine	41-55	cAMP responsive element binding protein 1	Mus musculus	124-128
18775326-5	2008	cAMP or Ca(2+) signaling promoted RGS13 accumulation in the nucleus, where it formed a complex with phosphorylated CREB and CBP/p300.	Cyclic AMP	0-4	cAMP responsive element binding protein 1	Mus musculus	115-119
18713928-5	2008	To demonstrate that nicotine reduced nociceptive input in this model, the lumbar spinal cords of a subgroup of these mice were stained for the phosphorylated form if CREB.	Nicotine	20-28	cAMP responsive element binding protein 1	Mus musculus	166-170
19160506-6	2008	These data suggest that the persistence of long-term memories may depend on reactivation of the cAMP/MAPK/CREB transcriptional pathway in the hippocampus during the circadian cycle.	Cyclic AMP	96-100	cAMP responsive element binding protein 1	Mus musculus	106-110
18577515-8	2008	Although the protein kinase A inhibitor H-89 abolished forskolin-stimulated CREB phosphorylation, it did not modify forskolin-induced GTP-Rap1 levels, excluding PKA participation.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	40-44	cAMP responsive element binding protein 1	Mus musculus	76-80
18577515-8	2008	Although the protein kinase A inhibitor H-89 abolished forskolin-stimulated CREB phosphorylation, it did not modify forskolin-induced GTP-Rap1 levels, excluding PKA participation.	Colforsin	55-64	cAMP responsive element binding protein 1	Mus musculus	76-80
18046304-0	2008	Chronic lithium salt treatment reduces CRE/CREB-directed gene transcription and reverses its upregulation by chronic psychosocial stress in transgenic reporter gene mice.	lithium salt	8-20	cAMP responsive element binding protein 1	Mus musculus	43-47
18046304-3	2008	We here investigated the effect of lithium on cAMP-responsive element (CRE)/CREB-mediated gene transcription in the brain, using transgenic reporter mice that express the luciferase reporter gene under the control of four copies of the rat somatostatin gene promoter CRE.	Lithium	35-42	cAMP responsive element binding protein 1	Mus musculus	76-80
18046304-4	2008	Chronic (21 days) but not acute (24 h) treatment with lithium (7.5 mmol/kg) significantly decreased CRE/CREB-directed gene expression in hippocampus, cortex, hypothalamus, and striatum to 60-70%, and likewise reduced CREB phosphorylation.	Lithium	54-61	cAMP responsive element binding protein 1	Mus musculus	104-108
18046304-4	2008	Chronic (21 days) but not acute (24 h) treatment with lithium (7.5 mmol/kg) significantly decreased CRE/CREB-directed gene expression in hippocampus, cortex, hypothalamus, and striatum to 60-70%, and likewise reduced CREB phosphorylation.	Lithium	54-61	cAMP responsive element binding protein 1	Mus musculus	217-221
18046304-7	2008	Treatment of stressed mice with lithium decreased stress-induced CRE/CREB-directed gene expression to control levels in nearly all brain regions and likewise reduced CREB phosphorylation.	Lithium	32-39	cAMP responsive element binding protein 1	Mus musculus	69-73
18046304-7	2008	Treatment of stressed mice with lithium decreased stress-induced CRE/CREB-directed gene expression to control levels in nearly all brain regions and likewise reduced CREB phosphorylation.	Lithium	32-39	cAMP responsive element binding protein 1	Mus musculus	166-170
18046304-8	2008	Chronic lithium treatment induced beta-catenin accumulation and decreased cAMP levels, indicating an inhibitory effect of lithium on glycogen synthase kinase 3 and the adenylate cyclase/protein kinase A signalling cascade, which are known to modulate CREB activity.	Lithium	8-15	cAMP responsive element binding protein 1	Mus musculus	251-255
18046304-8	2008	Chronic lithium treatment induced beta-catenin accumulation and decreased cAMP levels, indicating an inhibitory effect of lithium on glycogen synthase kinase 3 and the adenylate cyclase/protein kinase A signalling cascade, which are known to modulate CREB activity.	Lithium	122-129	cAMP responsive element binding protein 1	Mus musculus	251-255
18046304-9	2008	We here for the first time show that lithium regulates CRE/CREB-directed gene transcription in vivo and suggest CREB as a putative mediator of the neuronal adaptation after chronic lithium treatment.	Lithium	37-44	cAMP responsive element binding protein 1	Mus musculus	59-63
18046304-9	2008	We here for the first time show that lithium regulates CRE/CREB-directed gene transcription in vivo and suggest CREB as a putative mediator of the neuronal adaptation after chronic lithium treatment.	Lithium	37-44	cAMP responsive element binding protein 1	Mus musculus	112-116
18046304-9	2008	We here for the first time show that lithium regulates CRE/CREB-directed gene transcription in vivo and suggest CREB as a putative mediator of the neuronal adaptation after chronic lithium treatment.	Lithium	181-188	cAMP responsive element binding protein 1	Mus musculus	59-63
18046304-9	2008	We here for the first time show that lithium regulates CRE/CREB-directed gene transcription in vivo and suggest CREB as a putative mediator of the neuronal adaptation after chronic lithium treatment.	Lithium	181-188	cAMP responsive element binding protein 1	Mus musculus	112-116
18508907-6	2008	HRH1 agonists modulate small cholangiocyte proliferation by activation of IP(3)/Ca(2+)-dependent CaMK/CREB.	Inositol 1,4,5-Trisphosphate	74-79	cAMP responsive element binding protein 1	Mus musculus	102-106
18508907-16	2008	The IP(3)/Ca(2+)/CaMK I/CREB pathway is important in the regulation of small cholangiocyte function.	Inositol 1,4,5-Trisphosphate	4-9	cAMP responsive element binding protein 1	Mus musculus	24-28
18591870-5	2008	Moreover, we found that CM caused an increase in ceramide content in renal tubular cells, which leads to apoptosis by inhibiting the phosphorylation of Akt and cAMP responsive element binding protein (CREB) and the subsequent reduction in Bcl-2 expression.	Ceramides	49-57	cAMP responsive element binding protein 1	Mus musculus	160-199
18487450-10	2008	In hepatocyte cell lines, ROS induced phosphorylation of JNK and CREB, and the latter, together with PGC-1alpha expression, was inhibited by a JNK inhibitor.	Reactive Oxygen Species	26-29	cAMP responsive element binding protein 1	Mus musculus	65-69
18702734-1	2008	Elevation of intracellular cyclic adenosine monophosphate (cAMP) concentrations and subsequent regulation of downstream target gene expression through phosphorylation of cAMP-responsive element binding protein (CREB) is hypothesized to underlie the mechanism(s) of long-term memory (LTM) formation.	Cyclic AMP	27-57	cAMP responsive element binding protein 1	Mus musculus	170-209
18702734-1	2008	Elevation of intracellular cyclic adenosine monophosphate (cAMP) concentrations and subsequent regulation of downstream target gene expression through phosphorylation of cAMP-responsive element binding protein (CREB) is hypothesized to underlie the mechanism(s) of long-term memory (LTM) formation.	Cyclic AMP	27-57	cAMP responsive element binding protein 1	Mus musculus	211-215
18702734-1	2008	Elevation of intracellular cyclic adenosine monophosphate (cAMP) concentrations and subsequent regulation of downstream target gene expression through phosphorylation of cAMP-responsive element binding protein (CREB) is hypothesized to underlie the mechanism(s) of long-term memory (LTM) formation.	Cyclic AMP	59-63	cAMP responsive element binding protein 1	Mus musculus	170-209
18702734-1	2008	Elevation of intracellular cyclic adenosine monophosphate (cAMP) concentrations and subsequent regulation of downstream target gene expression through phosphorylation of cAMP-responsive element binding protein (CREB) is hypothesized to underlie the mechanism(s) of long-term memory (LTM) formation.	Cyclic AMP	59-63	cAMP responsive element binding protein 1	Mus musculus	211-215
18554320-0	2008	Enhanced CREB and DARPP-32 phosphorylation in the nucleus accumbens and CREB, ERK, and GluR1 phosphorylation in the dorsal hippocampus is associated with cocaine-conditioned place preference behavior.	Cocaine	154-161	cAMP responsive element binding protein 1	Mus musculus	9-13
18554320-0	2008	Enhanced CREB and DARPP-32 phosphorylation in the nucleus accumbens and CREB, ERK, and GluR1 phosphorylation in the dorsal hippocampus is associated with cocaine-conditioned place preference behavior.	Cocaine	154-161	cAMP responsive element binding protein 1	Mus musculus	72-76
18554320-4	2008	Our studies revealed that re-exposing mice to an environment in which they were previously given cocaine resulted in increased levels of Ser133 phospho-CREB and Thr34 phospho-DARPP-32 with a corresponding decrease in Thr75 phospho-DARPP-32 in the NAc.	Cocaine	97-104	cAMP responsive element binding protein 1	Mus musculus	152-156
18554320-5	2008	In DHC there were increased levels of phospho-CREB, Thr183/Tyr185 phospho-ERK, and Ser845 phospho-GluR1.	dhc	3-6	cAMP responsive element binding protein 1	Mus musculus	46-50
18554320-6	2008	These data suggest that the formation of contextual drug reward associations involves recruitment of the DHC-NAc circuit with activation of the DARPP-32/CREB pathway in the NAc and the ERK/CREB pathway in the DHC.	dhc	105-108	cAMP responsive element binding protein 1	Mus musculus	153-157
18554320-6	2008	These data suggest that the formation of contextual drug reward associations involves recruitment of the DHC-NAc circuit with activation of the DARPP-32/CREB pathway in the NAc and the ERK/CREB pathway in the DHC.	dhc	105-108	cAMP responsive element binding protein 1	Mus musculus	189-193
17957220-8	2008	In addition, morphine-induced ERK1/2 phosphorylation was increased in the VTA of both wild-type and GKO mice, but only the GKO mice showed increases in ERK1/2 and CREB phosphorylation in the amygdala or nucleus accumbens.	Morphine	13-21	cAMP responsive element binding protein 1	Mus musculus	163-167
18424767-0	2008	CREB has a context-dependent role in activity-regulated transcription and maintains neuronal cholesterol homeostasis.	Cholesterol	93-104	cAMP responsive element binding protein 1	Mus musculus	0-4
18467523-4	2008	Moreover, CYP51 and epidermal growth factor (EGF)-like factor [amphiregulin (AR)] expression were blocked by (2)-naphthol-AS-Ephosphate (KG-501) (a drug interrupting the formation of CREB functional complex).	(2)-naphthol-as-ephosphate	109-135	cAMP responsive element binding protein 1	Mus musculus	183-187
18467523-8	2008	Furthermore, type II PKA analog pairs, N(6)-monobutyryl-cAMP plus 8-bromo-cAMP, increased PKA RIIbeta level and mimicked the action of FSH, including CREB phosphorylation, AR and CYP51 expression, MAPK activation, and oocyte maturation.	monobutyryl cyclic AMP	39-60	cAMP responsive element binding protein 1	Mus musculus	150-154
18467523-8	2008	Furthermore, type II PKA analog pairs, N(6)-monobutyryl-cAMP plus 8-bromo-cAMP, increased PKA RIIbeta level and mimicked the action of FSH, including CREB phosphorylation, AR and CYP51 expression, MAPK activation, and oocyte maturation.	8-Bromo Cyclic Adenosine Monophosphate	66-78	cAMP responsive element binding protein 1	Mus musculus	150-154
18467523-8	2008	Furthermore, type II PKA analog pairs, N(6)-monobutyryl-cAMP plus 8-bromo-cAMP, increased PKA RIIbeta level and mimicked the action of FSH, including CREB phosphorylation, AR and CYP51 expression, MAPK activation, and oocyte maturation.	riibeta	94-101	cAMP responsive element binding protein 1	Mus musculus	150-154
18591870-5	2008	Moreover, we found that CM caused an increase in ceramide content in renal tubular cells, which leads to apoptosis by inhibiting the phosphorylation of Akt and cAMP responsive element binding protein (CREB) and the subsequent reduction in Bcl-2 expression.	Ceramides	49-57	cAMP responsive element binding protein 1	Mus musculus	201-205
18591870-7	2008	On the other hand, a prostacyclin analog beraprost prevented RCN in mice by the increase of endogenous cAMP and subsequent CREB phosphorylation resulted in enhancement of Bcl-2 expression.	Epoprostenol	21-33	cAMP responsive element binding protein 1	Mus musculus	123-127
18378685-1	2008	Many growth regulatory stimuli promote cAMP response element-binding protein (CREB) Ser(133) phosphorylation, but the physiologically relevant CREB-Ser(133) kinase(s) in the heart remains uncertain.	Serine	84-87	cAMP responsive element binding protein 1	Mus musculus	39-76
18378685-1	2008	Many growth regulatory stimuli promote cAMP response element-binding protein (CREB) Ser(133) phosphorylation, but the physiologically relevant CREB-Ser(133) kinase(s) in the heart remains uncertain.	Serine	84-87	cAMP responsive element binding protein 1	Mus musculus	78-82
18378685-7	2008	Pasteuralla multocida toxin (PMT), a direct Galpha(q) agonist that induces robust cardiomyocyte hypertrophy, also activates the PKD-CREB-Ser(133) phosphorylation pathway, leading to the accumulation of active PKD and Ser(133)-phosphorylated CREB in the nucleus, activation of a CRE-responsive promoter, and increased Bcl-2 (CREB target gene) expression in cardiomyocyte cultures.	Serine	137-140	cAMP responsive element binding protein 1	Mus musculus	241-245
18378685-3	2008	We show that thrombin activates a PKCdelta-PKD pathway leading to CREB-Ser(133) phosphorylation in cardiomyocytes and cardiac fibroblasts.	Serine	71-74	cAMP responsive element binding protein 1	Mus musculus	66-70
18378685-7	2008	Pasteuralla multocida toxin (PMT), a direct Galpha(q) agonist that induces robust cardiomyocyte hypertrophy, also activates the PKD-CREB-Ser(133) phosphorylation pathway, leading to the accumulation of active PKD and Ser(133)-phosphorylated CREB in the nucleus, activation of a CRE-responsive promoter, and increased Bcl-2 (CREB target gene) expression in cardiomyocyte cultures.	Serine	217-220	cAMP responsive element binding protein 1	Mus musculus	132-136
18378685-4	2008	alpha(1)-Adrenergic receptors also activate a PKCdelta-PKD-CREB-Ser(133) phosphorylation pathway in cardiomyocytes.	Serine	64-67	cAMP responsive element binding protein 1	Mus musculus	59-63
18378685-5	2008	Of note, while the epidermal growth factor (EGF) promotes CREB-Ser(133) phosphorylation via an ERK-RSK pathway in cardiac fibroblasts, the thrombin-dependent EGFR transactivation pathway leading to ERK-RSK activation does not lead to CREB-Ser(133) phosphorylation in this cell type.	Serine	63-66	cAMP responsive element binding protein 1	Mus musculus	58-62
18378685-9	2008	Collectively, these studies identify a novel Galpha(q)-PKCdelta-PKD-CREB-Ser(133) phosphorylation pathway that is predicted to contribute to cardiac remodeling and could be targeted for therapeutic advantage in the setting of heart failure phenotypes.	Serine	73-76	cAMP responsive element binding protein 1	Mus musculus	68-72
18378685-5	2008	Of note, while the epidermal growth factor (EGF) promotes CREB-Ser(133) phosphorylation via an ERK-RSK pathway in cardiac fibroblasts, the thrombin-dependent EGFR transactivation pathway leading to ERK-RSK activation does not lead to CREB-Ser(133) phosphorylation in this cell type.	Serine	239-242	cAMP responsive element binding protein 1	Mus musculus	58-62
18378685-7	2008	Pasteuralla multocida toxin (PMT), a direct Galpha(q) agonist that induces robust cardiomyocyte hypertrophy, also activates the PKD-CREB-Ser(133) phosphorylation pathway, leading to the accumulation of active PKD and Ser(133)-phosphorylated CREB in the nucleus, activation of a CRE-responsive promoter, and increased Bcl-2 (CREB target gene) expression in cardiomyocyte cultures.	Serine	137-140	cAMP responsive element binding protein 1	Mus musculus	132-136
18378685-7	2008	Pasteuralla multocida toxin (PMT), a direct Galpha(q) agonist that induces robust cardiomyocyte hypertrophy, also activates the PKD-CREB-Ser(133) phosphorylation pathway, leading to the accumulation of active PKD and Ser(133)-phosphorylated CREB in the nucleus, activation of a CRE-responsive promoter, and increased Bcl-2 (CREB target gene) expression in cardiomyocyte cultures.	Serine	137-140	cAMP responsive element binding protein 1	Mus musculus	241-245
17913473-14	2008	While papaverine treatment reduced CREB protein levels in the hippocampus and striatum, fluoxetine increased CREB in the hippocampus.	Papaverine	6-16	cAMP responsive element binding protein 1	Mus musculus	35-39
18567804-3	2008	In primary mouse keratinocyte cultures, PGE2 activated the epidermal growth factor receptor (EGFR) and its downstream signaling pathways as well as increased cyclic AMP (cAMP) production and activated the cAMP response element binding protein (CREB).	Dinoprostone	40-44	cAMP responsive element binding protein 1	Mus musculus	205-242
18567804-3	2008	In primary mouse keratinocyte cultures, PGE2 activated the epidermal growth factor receptor (EGFR) and its downstream signaling pathways as well as increased cyclic AMP (cAMP) production and activated the cAMP response element binding protein (CREB).	Dinoprostone	40-44	cAMP responsive element binding protein 1	Mus musculus	244-248
18567804-6	2008	In addition, these inhibitors attenuated the PGE2-induced proliferation, nuclear factor-kappa B, activator protein-1 (AP-1), and CREB binding to the promoter regions of the cyclin D1 and vascular endothelial growth factor (VEGF) genes and expression of cyclin D1 and VEGF in primary mouse keratinocytes.	Dinoprostone	45-49	cAMP responsive element binding protein 1	Mus musculus	129-133
18383274-3	2008	During embryoid body (EB) differentiation, the level of active cyclic AMP response element-binding protein (CREB) was relatively high when 5 microM RA treatment was performed.	Tretinoin	148-150	cAMP responsive element binding protein 1	Mus musculus	63-106
18383274-3	2008	During embryoid body (EB) differentiation, the level of active cyclic AMP response element-binding protein (CREB) was relatively high when 5 microM RA treatment was performed.	Tretinoin	148-150	cAMP responsive element binding protein 1	Mus musculus	108-112
18383274-4	2008	Inhibition of CREB activity committed EBs to becoming other germ layers, whereas increased expression of CREB enhanced NPC differentiation.	ethylbenzene	38-41	cAMP responsive element binding protein 1	Mus musculus	14-18
18383274-5	2008	Moreover, RA increased the expression of active CREB by enhancing the activity of JNK.	Tretinoin	10-12	cAMP responsive element binding protein 1	Mus musculus	48-52
18383274-6	2008	Our research suggests that CREB plays a role in RA-induced NPC differentiation by increasing the expression of active JNK.	Tretinoin	48-50	cAMP responsive element binding protein 1	Mus musculus	27-31
18567804-7	2008	Similarly, in vivo, we found that WT mice treated with PGE2 and untreated cyclooxygenase-2-overexpressing transgenic mice had higher levels of cell proliferation and expression of cyclin D1 and VEGF, as well as higher levels of activated EGFR, nuclear factor-kappa B, AP-1, and CREB, than vehicle-treated WT mice.	Dinoprostone	55-59	cAMP responsive element binding protein 1	Mus musculus	278-282
18424161-14	2008	Rolipram was effective in increasing significantly the levels of activated CREB and of BDNF the striatal spiny neurons, which might account for the beneficial effects observed in this model.	Rolipram	0-8	cAMP responsive element binding protein 1	Mus musculus	75-79
17913473-14	2008	While papaverine treatment reduced CREB protein levels in the hippocampus and striatum, fluoxetine increased CREB in the hippocampus.	Fluoxetine	88-98	cAMP responsive element binding protein 1	Mus musculus	109-113
17913473-15	2008	These data suggest that papaverine and fluoxetine may produce quite different effects on behavior; these behaviors may be linked to CREB expression in brain regions associated with motor and cognitive functions.	Papaverine	24-34	cAMP responsive element binding protein 1	Mus musculus	132-136
18328479-2	2008	It activates the cAMP-dependent protein kinase (PKA)/cAMP regulatory element-binding protein (CREB) signaling pathway and it inhibits inflammation.	Cyclic AMP	17-21	cAMP responsive element binding protein 1	Mus musculus	94-98
17913473-15	2008	These data suggest that papaverine and fluoxetine may produce quite different effects on behavior; these behaviors may be linked to CREB expression in brain regions associated with motor and cognitive functions.	Fluoxetine	39-49	cAMP responsive element binding protein 1	Mus musculus	132-136
18328479-2	2008	It activates the cAMP-dependent protein kinase (PKA)/cAMP regulatory element-binding protein (CREB) signaling pathway and it inhibits inflammation.	Cyclic AMP	53-57	cAMP responsive element binding protein 1	Mus musculus	94-98
18094030-0	2008	Restoration of CREB function ameliorates cisplatin cytotoxicity in renal tubular cells.	Cisplatin	41-50	cAMP responsive element binding protein 1	Mus musculus	15-19
18094030-3	2008	We now demonstrate that the cisplatin-induced activated EGFR/Ras/ERK signaling cascade fails to activate CREB-mediated transcription even in the presence of phosphorylated CREB.	Cisplatin	28-37	cAMP responsive element binding protein 1	Mus musculus	172-176
18850497-0	2008	Inhibition of Period1 gene attenuates the morphine-induced ERK-CREB activation in frontal cortex, hippocampus, and striatum in mice.	Morphine	42-50	cAMP responsive element binding protein 1	Mus musculus	63-67
18094030-4	2008	CREB-mediated transcription as well as survival was restored by the histone deacetylase (HDAC) inhibitor trichostatine A (TSA), an effective chemotherapeutic agent.	trichostatin A	105-120	cAMP responsive element binding protein 1	Mus musculus	0-4
18094030-4	2008	CREB-mediated transcription as well as survival was restored by the histone deacetylase (HDAC) inhibitor trichostatine A (TSA), an effective chemotherapeutic agent.	trichostatin A	122-125	cAMP responsive element binding protein 1	Mus musculus	0-4
18094030-5	2008	Similar to severe oxidant stress, TSA-mediated survival could be abrogated by inhibition of CREB-mediated transcription.	trichostatin A	34-37	cAMP responsive element binding protein 1	Mus musculus	92-96
18094030-6	2008	These studies confirm the importance of CREB-mediated transcription in the survival of renal cells subjected to either oxidant- or cisplatin-induced stress.	Cisplatin	131-140	cAMP responsive element binding protein 1	Mus musculus	40-44
18411703-5	2008	The influence of the cyclic AMP response element binding (CREB) protein expression following toluene inhalation was also examined.	Toluene	93-100	cAMP responsive element binding protein 1	Mus musculus	58-62
18411703-9	2008	Furthermore, repeated toluene inhalation increased the levels of CREB proteins in the limbic forebrain.	Toluene	22-29	cAMP responsive element binding protein 1	Mus musculus	65-69
17909078-8	2008	These results reveal a novel link between TLR4 and a calcium-dependent signaling cascade comprising CaMKIV-CREB-Bcl-2 that is essential for DC survival.	Calcium	53-60	cAMP responsive element binding protein 1	Mus musculus	107-111
18457359-0	2008	Inhibition of MITF and tyrosinase by paeonol-stimulated JNK/SAPK to reduction of phosphorylated CREB.	paeonol	37-44	cAMP responsive element binding protein 1	Mus musculus	96-100
18457359-4	2008	We also found that paeonol reduced phosphorylation of a cAMP responsive element binding protein (phospho-CREB), which binds and activates MITF.	paeonol	19-26	cAMP responsive element binding protein 1	Mus musculus	105-109
18457359-4	2008	We also found that paeonol reduced phosphorylation of a cAMP responsive element binding protein (phospho-CREB), which binds and activates MITF.	Cyclic AMP	56-60	cAMP responsive element binding protein 1	Mus musculus	105-109
18457359-7	2008	These results identify a mechanism in which paeonol induces the down-regulation of melanogenesis through inhibition of CREB phosphorylation, leading to the expression reduction of MITF and subsequently tyrosinase.	paeonol	44-51	cAMP responsive element binding protein 1	Mus musculus	119-123
18025410-6	2008	RESULTS: We identified four negative regulators of intracellular signaling that were rapidly and strongly activated by GLP-1: the regulator of G-protein-signaling RGS2; the cAMP response element-binding protein (CREB) antagonists cAMP response element modulator (CREM)-alpha and ICERI; and the dual specificity phosphatase DUSP14, a negative regulator of the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase 1/2 (ERK1/2) pathway.	Cyclic AMP	173-177	cAMP responsive element binding protein 1	Mus musculus	212-216
17123666-2	2008	One of the most robust assays for SCN melatonin receptor activation in mice is the inhibition of PACAP-induced phosphorylation of the transcription factor Ca(2+)/cAMP responsive element binding protein (CREB).	Cyclic AMP	162-166	cAMP responsive element binding protein 1	Mus musculus	203-207
17123666-5	2008	In SCN slices from young (2-4-month-old) mice, melatonin reduced the level of phospho-CREB immunoreactivity following PACAP treatment in a dose-dependent manner.	Melatonin	47-56	cAMP responsive element binding protein 1	Mus musculus	86-90
17962352-7	2008	Further studies showed that glucose induced CREB phosphorylation through Ca(2+)-PKA-ERK1/2 and Ca(2+)-PKC pathways.	Glucose	28-35	cAMP responsive element binding protein 1	Mus musculus	44-48
17962352-8	2008	Thus, the Ca(2+)-PKA-ERK1/2-CREB and Ca(2+)-PKC-CREB signaling pathways are involved in glucose-induced PANDER gene expression.	Glucose	88-95	cAMP responsive element binding protein 1	Mus musculus	28-32
17962352-8	2008	Thus, the Ca(2+)-PKA-ERK1/2-CREB and Ca(2+)-PKC-CREB signaling pathways are involved in glucose-induced PANDER gene expression.	Glucose	88-95	cAMP responsive element binding protein 1	Mus musculus	48-52
18850497-2	2008	We explored the effects of inhibiting expression in brain of Per1 on morphine conditioned place preference (CPP) and morphine-induced phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP-response element binding protein (CREB) in mice.	Morphine	117-125	cAMP responsive element binding protein 1	Mus musculus	201-238
18850497-2	2008	We explored the effects of inhibiting expression in brain of Per1 on morphine conditioned place preference (CPP) and morphine-induced phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP-response element binding protein (CREB) in mice.	Morphine	117-125	cAMP responsive element binding protein 1	Mus musculus	240-244
18850497-9	2008	Pretreatment with DRz164 significant attenuated the morphine-induced activation of ERK and CREB in the frontal cortex, hippocampus, and striatum.	drz164	18-24	cAMP responsive element binding protein 1	Mus musculus	91-95
18850497-9	2008	Pretreatment with DRz164 significant attenuated the morphine-induced activation of ERK and CREB in the frontal cortex, hippocampus, and striatum.	Morphine	52-60	cAMP responsive element binding protein 1	Mus musculus	91-95
17635106-8	2007	Moreover, ChIP (chromatin immunoprecipitation) assays were performed to show a decreased CREB binding to the G6Pase promoter in fasting wild-type mice after PCN treatment.	Pregnenolone Carbonitrile	157-160	cAMP responsive element binding protein 1	Mus musculus	89-93
18088278-8	2007	P-Ser133-CREB was reduced in the CA3 region of hippocampus in phosphomutant mice, and tianeptine decreased P-Ser133-CREB in this region in wild-type, but not in phosphomutant, mice.	tianeptine	86-96	cAMP responsive element binding protein 1	Mus musculus	107-120
18088278-9	2007	Tianeptine increased P-Ser133-CREB in the CA1 region in wild-type mice but not in phosphomutant GluR1 mice.	tianeptine	0-10	cAMP responsive element binding protein 1	Mus musculus	21-34
18758906-0	2008	Cyclic AMP enhances Smad-mediated BMP signaling through PKA-CREB pathway.	Cyclic AMP	0-10	cAMP responsive element binding protein 1	Mus musculus	60-64
18758906-6	2008	These data indicate that cAMP-PKA/CREB/CRE signaling potentially enhances BMP-induced transcription through the BRE in the promoter of the BMP-responsive gene through a PKA-mediated pathway.	Cyclic AMP	25-29	cAMP responsive element binding protein 1	Mus musculus	34-38
17996688-7	2007	Electrophoretic mobility shift assay (EMSA) verified that NF-kappaB, C/EBP, CREB and AP-1 were identified as responsible for the sulforaphane-mediated COX-2 down-regulation.	sulforaphane	129-141	cAMP responsive element binding protein 1	Mus musculus	76-80
17996688-9	2007	Taken together, these results demonstrate that sulforaphane effectively suppressed the LPS-induced COX-2 protein via modulation of multiple core promoter elements (NF-kappaB, C/EBP, CREB and AP-1) in the COX-2 transcriptional regulation.	sulforaphane	47-59	cAMP responsive element binding protein 1	Mus musculus	182-186
18003853-7	2007	Finally, MSK1 knock-out mice demonstrate a deficiency in cAMP response element-binding protein (CREB) phosphorylation after fear training, which persists after sodium butyrate injection.	Butyric Acid	160-175	cAMP responsive element binding protein 1	Mus musculus	96-100
17692820-2	2007	CREB phosphorylation occurs mainly at serine 133, but the phosphorylation site at serine 142 may also be important.	Serine	38-44	cAMP responsive element binding protein 1	Mus musculus	0-4
17965257-7	2007	Activation-state-specific antibodies showed serine 133 phosphorylated Creb1 localization was similar to Creb1 staining, except that there was no increase in staining at the eight-cell stage.	Serine	44-50	cAMP responsive element binding protein 1	Mus musculus	70-75
17965257-9	2007	Increased expression of phosphorylated Creb1 in the two-cell embryo was induced by brief exposure of embryos to ionomycin, but not by a dibutyryl cAMP.	Ionomycin	112-121	cAMP responsive element binding protein 1	Mus musculus	39-44
17965257-13	2007	The calmodulin antagonist, W-7, inhibited the ionomycin-induced localization of phosphorylated Creb1 in the nucleus.	Ionomycin	46-55	cAMP responsive element binding protein 1	Mus musculus	95-100
17965257-16	2007	The marked nuclear accumulation and phosphorylation of Creb1 at the two-cell stage occurred at the time of transcription from the embryonic genome and was regulated in a calcium- and calmodulin-dependent manner.	Calcium	170-177	cAMP responsive element binding protein 1	Mus musculus	55-60
17692820-2	2007	CREB phosphorylation occurs mainly at serine 133, but the phosphorylation site at serine 142 may also be important.	Serine	82-88	cAMP responsive element binding protein 1	Mus musculus	0-4
17692820-5	2007	After peripheral noxious stimulation CREB was phosphorylated in the spinal cord at serine 133 and 142 indicating a potential role of both residues in nociceptive processing.	Serine	83-89	cAMP responsive element binding protein 1	Mus musculus	37-41
17277233-7	2007	Cyclic AMP response element-binding protein (CREB) phosphorylation was elevated to a greater extent in keratinocytes from EP2 transgenic mice compared with those of WT mice following PGE2 treatment.	Dinoprostone	183-187	cAMP responsive element binding protein 1	Mus musculus	0-43
17651699-5	2007	Consistent with this, rosmarinic acid induced the phosphorylation of CRE-binding protein (CREB), but had no effect on the phosphorylation of p38(mapk) or the inhibition of Akt phosphorylation.	rosmarinic acid	22-37	cAMP responsive element binding protein 1	Mus musculus	69-88
17651699-5	2007	Consistent with this, rosmarinic acid induced the phosphorylation of CRE-binding protein (CREB), but had no effect on the phosphorylation of p38(mapk) or the inhibition of Akt phosphorylation.	rosmarinic acid	22-37	cAMP responsive element binding protein 1	Mus musculus	90-94
17651699-7	2007	This result was further confirmed by the fact that rosmarinic acid-induced phosphorylation of CREB was inhibited by H-89, but not by PD98059, a MEK1 inhibitor, or by LY294002, a phosphatidylinositol-3-kinase (PI3K) inhibitor.	rosmarinic acid	51-66	cAMP responsive element binding protein 1	Mus musculus	94-98
17651699-7	2007	This result was further confirmed by the fact that rosmarinic acid-induced phosphorylation of CREB was inhibited by H-89, but not by PD98059, a MEK1 inhibitor, or by LY294002, a phosphatidylinositol-3-kinase (PI3K) inhibitor.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	116-120	cAMP responsive element binding protein 1	Mus musculus	94-98
17277233-7	2007	Cyclic AMP response element-binding protein (CREB) phosphorylation was elevated to a greater extent in keratinocytes from EP2 transgenic mice compared with those of WT mice following PGE2 treatment.	Dinoprostone	183-187	cAMP responsive element binding protein 1	Mus musculus	45-49
17277233-8	2007	A protein kinase A (PKA) inhibitor reduced PGE2-mediated CREB phosphorylation in keratinocytes from EP2 transgenic mice.	Dinoprostone	43-47	cAMP responsive element binding protein 1	Mus musculus	57-61
17909266-6	2007	Treatment with the cAMP analog (Bu)(2)cAMP augmented phosphorylation of CREB (Ser(133)), cFos (Thr(325)), and cJun (ser(73)).	Cyclic AMP	19-23	cAMP responsive element binding protein 1	Mus musculus	72-76
17701055-2	2007	Our previous investigations have shown remarkable differences in retinae of melatonin-deficient (C57BL) and melatonin-proficient (C3H) mice with regard to the protein levels of PER1, CRY2, and phosphorylated (p) cyclic AMP response element binding protein (CREB).	Melatonin	76-85	cAMP responsive element binding protein 1	Mus musculus	212-255
17701055-2	2007	Our previous investigations have shown remarkable differences in retinae of melatonin-deficient (C57BL) and melatonin-proficient (C3H) mice with regard to the protein levels of PER1, CRY2, and phosphorylated (p) cyclic AMP response element binding protein (CREB).	Melatonin	76-85	cAMP responsive element binding protein 1	Mus musculus	257-261
17701055-2	2007	Our previous investigations have shown remarkable differences in retinae of melatonin-deficient (C57BL) and melatonin-proficient (C3H) mice with regard to the protein levels of PER1, CRY2, and phosphorylated (p) cyclic AMP response element binding protein (CREB).	Melatonin	108-117	cAMP responsive element binding protein 1	Mus musculus	212-255
17701055-2	2007	Our previous investigations have shown remarkable differences in retinae of melatonin-deficient (C57BL) and melatonin-proficient (C3H) mice with regard to the protein levels of PER1, CRY2, and phosphorylated (p) cyclic AMP response element binding protein (CREB).	Melatonin	108-117	cAMP responsive element binding protein 1	Mus musculus	257-261
17554073-10	2007	Pathway analyses demonstrated that diabetes-induced phosphorylation of p38 MAPK and its downstream target CREB was also inhibited by the ASO.	Oligonucleotides, Antisense	137-140	cAMP responsive element binding protein 1	Mus musculus	106-110
17909266-6	2007	Treatment with the cAMP analog (Bu)(2)cAMP augmented phosphorylation of CREB (Ser(133)), cFos (Thr(325)), and cJun (ser(73)).	Cyclic AMP	38-42	cAMP responsive element binding protein 1	Mus musculus	72-76
17909266-6	2007	Treatment with the cAMP analog (Bu)(2)cAMP augmented phosphorylation of CREB (Ser(133)), cFos (Thr(325)), and cJun (ser(73)).	Serine	78-81	cAMP responsive element binding protein 1	Mus musculus	72-76
17909266-7	2007	Chromatin immunoprecipitation studies revealed that the induction of CREB, cFos, and cJun by (Bu)(2)cAMP was correlated with protein-DNA interactions and recruitment of the coactivator CREB-binding protein (CBP) to the StAR promoter.	Cyclic AMP	100-104	cAMP responsive element binding protein 1	Mus musculus	69-73
17645870-5	2007	Treatment with H89, a PKA inhibitor, markedly decreased IL-4-induced AID expression, and over-expression of CREB enhanced it.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	15-18	cAMP responsive element binding protein 1	Mus musculus	108-112
17666045-3	2007	Although phosphorylation of CREB at Ser-133 is necessary for the stimulation of transcriptional activity, it is not sufficient.	Serine	36-39	cAMP responsive element binding protein 1	Mus musculus	28-32
17666045-4	2007	Here we demonstrate that in mouse cortical neurons, inhibition of the Ca(2+)-dependent protein phosphatase calcineurin by FK506 or cyclosporine A blocks CREB-dependent gene expression induced by depolarization without inhibiting depolarization-induced Ca(2+) influx or CREB Ser-133 phosphorylation.	Tacrolimus	122-127	cAMP responsive element binding protein 1	Mus musculus	153-157
17666045-4	2007	Here we demonstrate that in mouse cortical neurons, inhibition of the Ca(2+)-dependent protein phosphatase calcineurin by FK506 or cyclosporine A blocks CREB-dependent gene expression induced by depolarization without inhibiting depolarization-induced Ca(2+) influx or CREB Ser-133 phosphorylation.	Tacrolimus	122-127	cAMP responsive element binding protein 1	Mus musculus	269-273
17666045-4	2007	Here we demonstrate that in mouse cortical neurons, inhibition of the Ca(2+)-dependent protein phosphatase calcineurin by FK506 or cyclosporine A blocks CREB-dependent gene expression induced by depolarization without inhibiting depolarization-induced Ca(2+) influx or CREB Ser-133 phosphorylation.	Cyclosporine	131-145	cAMP responsive element binding protein 1	Mus musculus	153-157
17666045-4	2007	Here we demonstrate that in mouse cortical neurons, inhibition of the Ca(2+)-dependent protein phosphatase calcineurin by FK506 or cyclosporine A blocks CREB-dependent gene expression induced by depolarization without inhibiting depolarization-induced Ca(2+) influx or CREB Ser-133 phosphorylation.	Serine	274-277	cAMP responsive element binding protein 1	Mus musculus	153-157
17666045-6	2007	Stimulation of a CRE-luciferase reporter gene by depolarization was sensitive to FK506 throughout the entire time course of the transcriptional response, revealing that calcineurin activity is required to maintain CREB-dependent transcription.	Tacrolimus	81-86	cAMP responsive element binding protein 1	Mus musculus	214-218
17805301-3	2007	In response to pancreatic glucagon, TORC2 is de-phosphorylated at Ser 171 and transported to the nucleus, in which it stimulates the gluconeogenic programme by binding to CREB.	Serine	66-69	cAMP responsive element binding protein 1	Mus musculus	171-175
17616745-2	2007	Phosphorylation of cAMP response element binding protein (CREB) at serine-133 regulates gene expression in the heart.	Serine	67-73	cAMP responsive element binding protein 1	Mus musculus	19-56
17616745-2	2007	Phosphorylation of cAMP response element binding protein (CREB) at serine-133 regulates gene expression in the heart.	Serine	67-73	cAMP responsive element binding protein 1	Mus musculus	58-62
17616745-8	2007	Left ventricular contractile function was substantially reduced in CREB-S133A mice versus NTG mice and only modestly reduced in CREB-S133A-LZ mice (P &lt; 0.02).	lz	139-141	cAMP responsive element binding protein 1	Mus musculus	128-132
17596931-6	2007	This ovary-specific promoter contains response elements that bind cAMP-response element-binding protein (CREB) and the orphan nuclear receptors SF-1 and LRH-1, which are required for cAMP-mediated stimulation of CYP19 expression in granulosa and luteal cells during the estrous cycle and pregnancy.	Cyclic AMP	66-70	cAMP responsive element binding protein 1	Mus musculus	105-109
17687518-7	2007	CONCLUSION: These data suggest a newly recognised inhibitory role for histamine in CREB activity and draws attention to the potential role of histamine in adipocyte differentiation.	Histamine	70-79	cAMP responsive element binding protein 1	Mus musculus	83-87
18019427-4	2007	RESULTS: At a nontoxic dose, Flavin7 markedly reduced phosphorylation of ERK and inhibited activity of its downstream targets such as Elk1 and CREB via inhibition of the ERK-kinase MEK1.	Flavin7	29-36	cAMP responsive element binding protein 1	Mus musculus	143-147
17870172-6	2007	NMDA NR2A, calcium/calmodulin-dependent protein kinase IV (CaMKIV), cyclic AMP-responsive element binding protein 1 (CREB1), and BDNF were significantly up-regulated in the hippocampi of WT mice exposed to 9ppm of toluene, compared to the expressions observed in WT mice exposed to filtered air, but similar results were not observed in nude mice.	Toluene	214-221	cAMP responsive element binding protein 1	Mus musculus	117-122
17524392-8	2007	Whereas increased Stat3 phosphorylation occurs after LMO4 and cIAP2 induction, the rapid upregulated phosphorylation of ERK and CREB may account for increased LMO4 and cIAP2 by ATP.	Adenosine Triphosphate	177-180	cAMP responsive element binding protein 1	Mus musculus	128-132
17524392-9	2007	ATP signaling through ERK and CREB activated LMO4 promoters and ERK activation increased LMO4 protein stability in F11 cells.	Adenosine Triphosphate	0-3	cAMP responsive element binding protein 1	Mus musculus	30-34
17650175-12	2007	CONCLUSIONS: Our study shows that DMHF inhibits alpha-MSH-induced melanogenesis by suppressing CREB phosphorylation, which is induced by protein kinase A, and suggests that DMHF may be an effective inhibitor of hyperpigmentation.	furaneol	34-38	cAMP responsive element binding protein 1	Mus musculus	95-99
17687518-0	2007	Elevated CREB activity in embryonic fibroblasts of gene-targeted histamine deficient mice.	Histamine	65-74	cAMP responsive element binding protein 1	Mus musculus	9-13
17687518-1	2007	OBJECTIVES: Histamine is a known inducer of cAMP-responsive element binding protein (CREB), which plays a key role in initiation of adipogenesis.	Histamine	12-21	cAMP responsive element binding protein 1	Mus musculus	44-83
17687518-1	2007	OBJECTIVES: Histamine is a known inducer of cAMP-responsive element binding protein (CREB), which plays a key role in initiation of adipogenesis.	Histamine	12-21	cAMP responsive element binding protein 1	Mus musculus	85-89
17634380-3	2007	Here, we show that, at baseline, CREB(alpha delta) mutant mice exhibited increased hippocampal cell proliferation and neurogenesis compared with wild-type (WT) controls, effects similar to those observed in WT mice after chronic desipramine (DMI) administration.	Desipramine	229-240	cAMP responsive element binding protein 1	Mus musculus	33-37
17634380-3	2007	Here, we show that, at baseline, CREB(alpha delta) mutant mice exhibited increased hippocampal cell proliferation and neurogenesis compared with wild-type (WT) controls, effects similar to those observed in WT mice after chronic desipramine (DMI) administration.	Desipramine	242-245	cAMP responsive element binding protein 1	Mus musculus	33-37
17634380-5	2007	Serotonin depletion decreased neurogenesis in CREB(alpha delta) mutant mice to WT levels, which correlated with a reversal of the antidepressant phenotype in the TST.	Serotonin	0-9	cAMP responsive element binding protein 1	Mus musculus	46-50
17346696-6	2007	Magnolol effectively inhibited the NF-kappaB-dependent transcription, but no effect was observed with other inducible transcription factors such as activator protein-1 (AP-1) and cyclic-AMP responsive element-binding protein (CREB).	magnolol	0-8	cAMP responsive element binding protein 1	Mus musculus	226-230
17446183-6	2007	Kinetic studies of wild-type ovine FSHBLuc in LbetaT2 cells showed continuous induction by activin (4-fold) over 20 h. Most of this induction (78%) was blocked, beginning at 6 h. cAMP response element binding protein (CREB) was implicated in this inhibition because overexpression of its constitutively active mutant mimicked GnRH, and its inhibitor (inducible cAMP early repressor isoform II) reversed the inhibition caused by GnRH, forskolin, or PMA.	Cyclic AMP	179-183	cAMP responsive element binding protein 1	Mus musculus	218-222
17446183-6	2007	Kinetic studies of wild-type ovine FSHBLuc in LbetaT2 cells showed continuous induction by activin (4-fold) over 20 h. Most of this induction (78%) was blocked, beginning at 6 h. cAMP response element binding protein (CREB) was implicated in this inhibition because overexpression of its constitutively active mutant mimicked GnRH, and its inhibitor (inducible cAMP early repressor isoform II) reversed the inhibition caused by GnRH, forskolin, or PMA.	Colforsin	434-443	cAMP responsive element binding protein 1	Mus musculus	179-216
17446183-6	2007	Kinetic studies of wild-type ovine FSHBLuc in LbetaT2 cells showed continuous induction by activin (4-fold) over 20 h. Most of this induction (78%) was blocked, beginning at 6 h. cAMP response element binding protein (CREB) was implicated in this inhibition because overexpression of its constitutively active mutant mimicked GnRH, and its inhibitor (inducible cAMP early repressor isoform II) reversed the inhibition caused by GnRH, forskolin, or PMA.	Tetradecanoylphorbol Acetate	448-451	cAMP responsive element binding protein 1	Mus musculus	179-216
17446183-7	2007	In addition, GnRH, forskolin, or PMA increased the expression of a CREB-responsive reporter gene, 6xCRE-37PRL-Luc.	Colforsin	19-28	cAMP responsive element binding protein 1	Mus musculus	67-71
17446183-7	2007	In addition, GnRH, forskolin, or PMA increased the expression of a CREB-responsive reporter gene, 6xCRE-37PRL-Luc.	Tetradecanoylphorbol Acetate	33-36	cAMP responsive element binding protein 1	Mus musculus	67-71
17522299-3	2007	In a transgenic mouse model of ALS expressing the G86R mutant superoxide dismutase 1 (mSOD1), we demonstrated previously that CREB (cAMP response element-binding protein)-binding protein (CBP) and histone acetylation levels were specifically decreased in nuclei of degenerating MNs.	Cyclic AMP	132-136	cAMP responsive element binding protein 1	Mus musculus	126-130
17322281-0	2007	Asbestos-mediated CREB phosphorylation is regulated by protein kinase A and extracellular signal-regulated kinases 1/2.	Asbestos	0-8	cAMP responsive element binding protein 1	Mus musculus	18-22
17322281-3	2007	Because CREs (Ca(2+)/cAMP-response elements) are found in the promoters of many genes important for regulation of proliferation and apoptosis, CREB (CRE binding protein) is likely to play an important role in the development of asbestos-mediated lung injury.	Cyclic AMP	21-25	cAMP responsive element binding protein 1	Mus musculus	143-147
17322281-3	2007	Because CREs (Ca(2+)/cAMP-response elements) are found in the promoters of many genes important for regulation of proliferation and apoptosis, CREB (CRE binding protein) is likely to play an important role in the development of asbestos-mediated lung injury.	Cyclic AMP	21-25	cAMP responsive element binding protein 1	Mus musculus	149-168
17322281-4	2007	To explore this possibility, we tested the hypotheses that asbestos exposure leads to CREB phosphorylation in lung epithelial cells and that protein kinase A (PKA) and extracellular signal-regulated kinases 1/2 (ERK1/2) are central regulators of the CREB pathway.	Asbestos	59-67	cAMP responsive element binding protein 1	Mus musculus	86-90
17322281-8	2007	Silencing CREB protein dramatically reduced asbestos-mediated ERK1/2 phosphorylation, yet significantly increased the number of cells undergoing asbestos-induced apoptosis.	Asbestos	44-52	cAMP responsive element binding protein 1	Mus musculus	10-14
17322281-8	2007	Silencing CREB protein dramatically reduced asbestos-mediated ERK1/2 phosphorylation, yet significantly increased the number of cells undergoing asbestos-induced apoptosis.	Asbestos	145-153	cAMP responsive element binding protein 1	Mus musculus	10-14
17322281-9	2007	These data reveal a novel and selective role for CREB in asbestos-mediated signaling through pathways regulated by PKA and ERK1/2, further providing evidence that CREB is an important regulator of apoptosis in asbestos-induced responses of lung epithelial cells.	Asbestos	57-65	cAMP responsive element binding protein 1	Mus musculus	49-53
17322281-9	2007	These data reveal a novel and selective role for CREB in asbestos-mediated signaling through pathways regulated by PKA and ERK1/2, further providing evidence that CREB is an important regulator of apoptosis in asbestos-induced responses of lung epithelial cells.	Asbestos	57-65	cAMP responsive element binding protein 1	Mus musculus	163-167
17322281-9	2007	These data reveal a novel and selective role for CREB in asbestos-mediated signaling through pathways regulated by PKA and ERK1/2, further providing evidence that CREB is an important regulator of apoptosis in asbestos-induced responses of lung epithelial cells.	Asbestos	210-218	cAMP responsive element binding protein 1	Mus musculus	49-53
17322281-9	2007	These data reveal a novel and selective role for CREB in asbestos-mediated signaling through pathways regulated by PKA and ERK1/2, further providing evidence that CREB is an important regulator of apoptosis in asbestos-induced responses of lung epithelial cells.	Asbestos	210-218	cAMP responsive element binding protein 1	Mus musculus	163-167
17307839-1	2007	The transcription factor cAMP response element (CRE)-binding protein (CREB, Creb1) plays a critical role in regulating gene expression in response to activation of the cAMP-dependent signaling pathway, which is implicated in the pathophysiology of heart failure.	Cyclic AMP	25-29	cAMP responsive element binding protein 1	Mus musculus	70-74
17307839-1	2007	The transcription factor cAMP response element (CRE)-binding protein (CREB, Creb1) plays a critical role in regulating gene expression in response to activation of the cAMP-dependent signaling pathway, which is implicated in the pathophysiology of heart failure.	Cyclic AMP	25-29	cAMP responsive element binding protein 1	Mus musculus	76-81
17307839-1	2007	The transcription factor cAMP response element (CRE)-binding protein (CREB, Creb1) plays a critical role in regulating gene expression in response to activation of the cAMP-dependent signaling pathway, which is implicated in the pathophysiology of heart failure.	Cyclic AMP	168-172	cAMP responsive element binding protein 1	Mus musculus	70-74
17307839-1	2007	The transcription factor cAMP response element (CRE)-binding protein (CREB, Creb1) plays a critical role in regulating gene expression in response to activation of the cAMP-dependent signaling pathway, which is implicated in the pathophysiology of heart failure.	Cyclic AMP	168-172	cAMP responsive element binding protein 1	Mus musculus	76-81
17448895-7	2007	Significant inhibition of STAT3 &amp; CREB were also observed along with the inhibition of HO-1 mRNA.	Adenosine Monophosphate	33-36	cAMP responsive element binding protein 1	Mus musculus	38-42
17074386-0	2007	Calcium release by ryanodine receptors mediates hydrogen peroxide-induced activation of ERK and CREB phosphorylation in N2a cells and hippocampal neurons.	Calcium	0-7	cAMP responsive element binding protein 1	Mus musculus	96-100
17487276-8	2007	Treatment of the stressed mice with the antidepressant imipramine normalized luciferase expression to control levels in all brain regions and likewise reduced CREB-phosphorylation.	Imipramine	55-65	cAMP responsive element binding protein 1	Mus musculus	159-163
17074386-6	2007	In N2a cells in calcium-free media, 200 microM H2O2 stimulated ERK and CREB phosphorylation, while preincubation with thapsigargin prevented these enhancements.	Hydrogen Peroxide	47-51	cAMP responsive element binding protein 1	Mus musculus	71-75
17074386-7	2007	These combined results strongly suggest that H2O2 promotes ryanodine receptors redox modification; the resulting calcium release signals, by enhancing ERK activity, would increase CREB phosphorylation.	Hydrogen Peroxide	45-49	cAMP responsive element binding protein 1	Mus musculus	180-184
17074386-0	2007	Calcium release by ryanodine receptors mediates hydrogen peroxide-induced activation of ERK and CREB phosphorylation in N2a cells and hippocampal neurons.	Hydrogen Peroxide	48-65	cAMP responsive element binding protein 1	Mus musculus	96-100
17074386-7	2007	These combined results strongly suggest that H2O2 promotes ryanodine receptors redox modification; the resulting calcium release signals, by enhancing ERK activity, would increase CREB phosphorylation.	Calcium	113-120	cAMP responsive element binding protein 1	Mus musculus	180-184
17074386-8	2007	We propose that ryanodine receptor stimulation by activity-generated redox species produces calcium release signals that may contribute significantly to hippocampal synaptic plasticity, including plasticity that requires long-lasting ERK-dependent CREB phosphorylation.	Calcium	92-99	cAMP responsive element binding protein 1	Mus musculus	248-252
17074386-3	2007	In mouse hippocampal slices, H2O2 (1 microM) also stimulated ERK and CREB phosphorylation.	Hydrogen Peroxide	29-33	cAMP responsive element binding protein 1	Mus musculus	69-73
17074386-4	2007	Preincubation with ryanodine (50 microM) largely prevented the effects of H2O2 on calcium signals and ERK/CREB phosphorylation.	Ryanodine	19-28	cAMP responsive element binding protein 1	Mus musculus	106-110
17074386-5	2007	In N2a cells, the ERK kinase inhibitor U0126 suppressed ERK phosphorylation and abolished the stimulation of CREB phosphorylation produced by H2O2, suggesting that H2O2 enhanced CREB phosphorylation via ERK activation.	U 0126	39-44	cAMP responsive element binding protein 1	Mus musculus	109-113
17074386-5	2007	In N2a cells, the ERK kinase inhibitor U0126 suppressed ERK phosphorylation and abolished the stimulation of CREB phosphorylation produced by H2O2, suggesting that H2O2 enhanced CREB phosphorylation via ERK activation.	U 0126	39-44	cAMP responsive element binding protein 1	Mus musculus	178-182
17074386-5	2007	In N2a cells, the ERK kinase inhibitor U0126 suppressed ERK phosphorylation and abolished the stimulation of CREB phosphorylation produced by H2O2, suggesting that H2O2 enhanced CREB phosphorylation via ERK activation.	Hydrogen Peroxide	142-146	cAMP responsive element binding protein 1	Mus musculus	109-113
17074386-5	2007	In N2a cells, the ERK kinase inhibitor U0126 suppressed ERK phosphorylation and abolished the stimulation of CREB phosphorylation produced by H2O2, suggesting that H2O2 enhanced CREB phosphorylation via ERK activation.	Hydrogen Peroxide	142-146	cAMP responsive element binding protein 1	Mus musculus	178-182
17074386-5	2007	In N2a cells, the ERK kinase inhibitor U0126 suppressed ERK phosphorylation and abolished the stimulation of CREB phosphorylation produced by H2O2, suggesting that H2O2 enhanced CREB phosphorylation via ERK activation.	Hydrogen Peroxide	164-168	cAMP responsive element binding protein 1	Mus musculus	109-113
17074386-5	2007	In N2a cells, the ERK kinase inhibitor U0126 suppressed ERK phosphorylation and abolished the stimulation of CREB phosphorylation produced by H2O2, suggesting that H2O2 enhanced CREB phosphorylation via ERK activation.	Hydrogen Peroxide	164-168	cAMP responsive element binding protein 1	Mus musculus	178-182
17379823-5	2007	Thus, activation of cAMP-CREB signaling may provide a promising strategy for enhancing the survival of newborn neurons.	Cyclic AMP	20-24	cAMP responsive element binding protein 1	Mus musculus	25-29
17379823-11	2007	We examined whether the activation of cAMP-CREB signaling by rolipram enhanced the proliferation and survival of newborn neurons.	Cyclic AMP	38-42	cAMP responsive element binding protein 1	Mus musculus	43-47
17379823-11	2007	We examined whether the activation of cAMP-CREB signaling by rolipram enhanced the proliferation and survival of newborn neurons.	Rolipram	61-69	cAMP responsive element binding protein 1	Mus musculus	43-47
17379823-17	2007	Chronic pharmacological activation of cAMP-CREB signaling may be therapeutically useful for the enhancement of neurogenesis after ischemia.	Cyclic AMP	38-42	cAMP responsive element binding protein 1	Mus musculus	43-47
17446403-2	2007	To examine neuronal competition during memory formation, we conducted experiments with mice in which we manipulated the function of CREB (adenosine 3",5"-monophosphate response element-binding protein) in subsets of neurons.	Cyclic AMP	138-167	cAMP responsive element binding protein 1	Mus musculus	132-136
17244698-8	2007	Cotransfection of cells with a plasmid encoding the dominant-negative CRE binding protein (CREB) completely abolished the inducibility of the reporter gene activity by forskolin.	Colforsin	168-177	cAMP responsive element binding protein 1	Mus musculus	70-89
17043650-6	2007	LiCl, an inhibitor of GSK3beta, abolished inhibitory effect of PTEN on cyclin D2 expression, and TCF members could directly bind to the promoter of cyclin D2 and regulate its transcription in a CREB-dependent manner.	Lithium Chloride	0-4	cAMP responsive element binding protein 1	Mus musculus	194-198
17344422-7	2007	AngII stimulated phosphorylation of cAMP response element binding protein (CREB) on Ser-133 and assembly of p-CREB on the BdkrB2 promoter in vivo.	Serine	84-87	cAMP responsive element binding protein 1	Mus musculus	36-73
17344422-7	2007	AngII stimulated phosphorylation of cAMP response element binding protein (CREB) on Ser-133 and assembly of p-CREB on the BdkrB2 promoter in vivo.	Serine	84-87	cAMP responsive element binding protein 1	Mus musculus	75-79
17244698-8	2007	Cotransfection of cells with a plasmid encoding the dominant-negative CRE binding protein (CREB) completely abolished the inducibility of the reporter gene activity by forskolin.	Colforsin	168-177	cAMP responsive element binding protein 1	Mus musculus	91-95
17277356-0	2007	Glycogen synthase kinase-3 represses cyclic AMP response element-binding protein (CREB)-targeted immediate early genes in quiescent cells.	Cyclic AMP	37-47	cAMP responsive element binding protein 1	Mus musculus	82-86
17277356-6	2007	Binding sites predicted in 6 genes were confirmed by CREB chromatin immunoprecipitation and forskolin induction of CBP binding.	Colforsin	92-101	cAMP responsive element binding protein 1	Mus musculus	53-57
17277356-7	2007	Moreover, CREB siRNA substantially blocked induction of 5 genes by forskolin and of 3 genes following inhibition of GSK-3.	Colforsin	67-76	cAMP responsive element binding protein 1	Mus musculus	10-14
17382888-2	2007	Here we report that MAPK and CREB-mediated transcription are negatively regulated by SCOP (suprachiasmatic nucleus [SCN] circadian oscillatory protein) and that SCOP is proteolyzed by calpain when hippocampal neurons are stimulated by brain-derived neurotrophic factor (BDNF), KCl depolarization, or NMDA.	N-Methylaspartate	300-304	cAMP responsive element binding protein 1	Mus musculus	29-33
17197172-0	2007	Activation of MAPKs by 1alpha,25(OH)2-Vitamin D3 and 17beta-estradiol in skeletal muscle cells leads to phosphorylation of Elk-1 and CREB transcription factors.	25(oh)2-vitamin d3	30-48	cAMP responsive element binding protein 1	Mus musculus	133-137
17382888-2	2007	Here we report that MAPK and CREB-mediated transcription are negatively regulated by SCOP (suprachiasmatic nucleus [SCN] circadian oscillatory protein) and that SCOP is proteolyzed by calpain when hippocampal neurons are stimulated by brain-derived neurotrophic factor (BDNF), KCl depolarization, or NMDA.	Potassium Chloride	277-280	cAMP responsive element binding protein 1	Mus musculus	29-33
17197172-6	2007	1alpha,25(OH)(2)D(3) and 17beta-estradiol also induced the phosphorylation of CREB and Elk-1 transcription factors in an ERK1/2-dependent manner.	Estradiol	25-41	cAMP responsive element binding protein 1	Mus musculus	78-82
17197172-0	2007	Activation of MAPKs by 1alpha,25(OH)2-Vitamin D3 and 17beta-estradiol in skeletal muscle cells leads to phosphorylation of Elk-1 and CREB transcription factors.	Estradiol	53-69	cAMP responsive element binding protein 1	Mus musculus	133-137
17141199-7	2007	Furthermore, PAO dose-dependently inhibited the increased cAMP accumulation by either ISO or forskolin and suppressed the phosphorylation of CREB, an important transcriptional factor for IL-6 gene expression.	oxophenylarsine	13-16	cAMP responsive element binding protein 1	Mus musculus	141-145
17141199-0	2007	Phenylarsine oxide inhibited beta-adrenergic receptor-mediated IL-6 secretion: inhibition of cAMP accumulation and CREB activation in cardiac fibroblasts.	oxophenylarsine	0-18	cAMP responsive element binding protein 1	Mus musculus	115-119
17141199-10	2007	To our knowledge, this is the first report that PAO can inhibit ISO-induced IL-6 expression and CREB phosphorylation, demonstrating that PTPs may negatively regulate beta-AR-mediated IL-6 production.	oxophenylarsine	48-51	cAMP responsive element binding protein 1	Mus musculus	96-100
17404063-5	2007	We found that EGCG inhibited TPA-induced DNA binding of NF-kappaB and CREB in mouse skin in vivo.	epigallocatechin gallate	14-18	cAMP responsive element binding protein 1	Mus musculus	70-74
17027144-5	2007	Bisindolylmaleimide partially inhibited the CRF-mediated increase in CREB phosphorylation, but only in AtT-20 cells, suggesting that the protein kinase C pathway is involved in regulation of CREB phosphorylation via CRF1 receptor but not CRF2 receptor.	bisindolylmaleimide	0-19	cAMP responsive element binding protein 1	Mus musculus	69-73
17027144-5	2007	Bisindolylmaleimide partially inhibited the CRF-mediated increase in CREB phosphorylation, but only in AtT-20 cells, suggesting that the protein kinase C pathway is involved in regulation of CREB phosphorylation via CRF1 receptor but not CRF2 receptor.	bisindolylmaleimide	0-19	cAMP responsive element binding protein 1	Mus musculus	191-195
17404063-0	2007	Epigallocatechin gallate inhibits phorbol ester-induced activation of NF-kappa B and CREB in mouse skin: role of p38 MAPK.	epigallocatechin gallate	0-24	cAMP responsive element binding protein 1	Mus musculus	85-89
17404063-5	2007	We found that EGCG inhibited TPA-induced DNA binding of NF-kappaB and CREB in mouse skin in vivo.	Tetradecanoylphorbol Acetate	29-32	cAMP responsive element binding protein 1	Mus musculus	70-74
17404063-0	2007	Epigallocatechin gallate inhibits phorbol ester-induced activation of NF-kappa B and CREB in mouse skin: role of p38 MAPK.	Phorbol Esters	34-47	cAMP responsive element binding protein 1	Mus musculus	85-89
17404063-8	2007	Pretreatment with U0126 and SB203580, pharmacological inhibitors of ERK and p38 MAPK, respectively, showed that SB203580, but not U0126, attenuated TPA-induced CREB DNA binding in mouse skin.	SB 203580	112-120	cAMP responsive element binding protein 1	Mus musculus	160-164
17404063-8	2007	Pretreatment with U0126 and SB203580, pharmacological inhibitors of ERK and p38 MAPK, respectively, showed that SB203580, but not U0126, attenuated TPA-induced CREB DNA binding in mouse skin.	Tetradecanoylphorbol Acetate	148-151	cAMP responsive element binding protein 1	Mus musculus	160-164
17404063-9	2007	Taken together, EGCG inhibited TPA-induced DNA binding of NF-kappaB and CREB by blocking activation of p38 MAPK, which may provide a molecular basis of COX-2 inhibition by EGCG in mouse skin in vivo.	epigallocatechin gallate	16-20	cAMP responsive element binding protein 1	Mus musculus	72-76
17404063-9	2007	Taken together, EGCG inhibited TPA-induced DNA binding of NF-kappaB and CREB by blocking activation of p38 MAPK, which may provide a molecular basis of COX-2 inhibition by EGCG in mouse skin in vivo.	Tetradecanoylphorbol Acetate	31-34	cAMP responsive element binding protein 1	Mus musculus	72-76
17404063-9	2007	Taken together, EGCG inhibited TPA-induced DNA binding of NF-kappaB and CREB by blocking activation of p38 MAPK, which may provide a molecular basis of COX-2 inhibition by EGCG in mouse skin in vivo.	epigallocatechin gallate	172-176	cAMP responsive element binding protein 1	Mus musculus	72-76
17198542-3	2007	Here we investigated the expression of two clock genes (Per1, Cry2) and the level of phosphorylated (p) cyclic AMP response element binding protein (CREB) in retinae of melatonin-deficient (C57BL) with an intact retina and melatonin-proficient (C3H) mice with degenerated outer nuclear layer.	Melatonin	169-178	cAMP responsive element binding protein 1	Mus musculus	149-153
16905344-10	2007	We further found that intraaccumbal CREB antisense oligodeoxynucleotide infusion diminished cocaine-induced CPP, whereas did not affect the methamphetamine-induced CPP.	Oligodeoxyribonucleotides	51-71	cAMP responsive element binding protein 1	Mus musculus	36-40
17687191-9	2007	VDR, CRE-binding protein (CREB1) and NCOR1 were identified in the complex binding to the CRE-like domain by Western blot in the paricalcitol-treated cells.	paricalcitol	128-140	cAMP responsive element binding protein 1	Mus musculus	26-31
16905344-10	2007	We further found that intraaccumbal CREB antisense oligodeoxynucleotide infusion diminished cocaine-induced CPP, whereas did not affect the methamphetamine-induced CPP.	Cocaine	92-99	cAMP responsive element binding protein 1	Mus musculus	36-40
16905344-11	2007	Taken together, these data suggest that protein synthesis and accumbal CREB phosphorylation are essential for the learning and consolidation of the cocaine-induced CPP, whereas methamphetamine-induced CPP may be unrelated to the synthesis of new proteins.	Cocaine	148-155	cAMP responsive element binding protein 1	Mus musculus	71-75
17050165-2	2006	HT22 cells resistant to glutamate displayed increased phosphorylation of cAMP-response-element binding (CREB) and decreased ERK1/2 suggestive of differences in signal transmission.	Glutamic Acid	24-33	cAMP responsive element binding protein 1	Mus musculus	73-102
17029965-3	2007	One pathway that may couple SE to transcriptionally dependent alterations in CNS physiology is the CREB (cAMP response element-binding protein)/CRE (cAMP response element) cascade.	Cyclic AMP	105-109	cAMP responsive element binding protein 1	Mus musculus	99-103
17029965-4	2007	Here, we utilized the pilocarpine model of SE on a mouse strain transgenic for a CRE-reporter construct (beta-galactosidase) to begin to characterize how seizure activity regulates the activation state of the CREB/CRE pathway in both glia and neurons of the hippocampus.	Pilocarpine	22-33	cAMP responsive element binding protein 1	Mus musculus	209-213
16983645-0	2006	Differential effects of chronic amphetamine and baclofen administration on cAMP levels and phosphorylation of CREB in distinct brain regions of wild type and monoamine oxidase B-deficient mice.	Amphetamine	32-43	cAMP responsive element binding protein 1	Mus musculus	110-114
16983645-0	2006	Differential effects of chronic amphetamine and baclofen administration on cAMP levels and phosphorylation of CREB in distinct brain regions of wild type and monoamine oxidase B-deficient mice.	Baclofen	48-56	cAMP responsive element binding protein 1	Mus musculus	110-114
16983645-5	2006	After the last treatment, levels of cAMP and phosphorylated (p) cyclic-AMP response element binding protein (CREB) were up-regulated in the striatum and somatosensory cortex of Amph-treated WT mice, while similar to the saline-controls in the baclofen+Amph-treated group, indicating the blockade by baclofen to Amph.	Amphetamine	177-181	cAMP responsive element binding protein 1	Mus musculus	64-107
16983645-5	2006	After the last treatment, levels of cAMP and phosphorylated (p) cyclic-AMP response element binding protein (CREB) were up-regulated in the striatum and somatosensory cortex of Amph-treated WT mice, while similar to the saline-controls in the baclofen+Amph-treated group, indicating the blockade by baclofen to Amph.	Amphetamine	177-181	cAMP responsive element binding protein 1	Mus musculus	109-113
16983645-5	2006	After the last treatment, levels of cAMP and phosphorylated (p) cyclic-AMP response element binding protein (CREB) were up-regulated in the striatum and somatosensory cortex of Amph-treated WT mice, while similar to the saline-controls in the baclofen+Amph-treated group, indicating the blockade by baclofen to Amph.	Sodium Chloride	220-226	cAMP responsive element binding protein 1	Mus musculus	109-113
16983645-5	2006	After the last treatment, levels of cAMP and phosphorylated (p) cyclic-AMP response element binding protein (CREB) were up-regulated in the striatum and somatosensory cortex of Amph-treated WT mice, while similar to the saline-controls in the baclofen+Amph-treated group, indicating the blockade by baclofen to Amph.	Baclofen	243-251	cAMP responsive element binding protein 1	Mus musculus	109-113
16983645-5	2006	After the last treatment, levels of cAMP and phosphorylated (p) cyclic-AMP response element binding protein (CREB) were up-regulated in the striatum and somatosensory cortex of Amph-treated WT mice, while similar to the saline-controls in the baclofen+Amph-treated group, indicating the blockade by baclofen to Amph.	Amphetamine	252-256	cAMP responsive element binding protein 1	Mus musculus	109-113
16983645-5	2006	After the last treatment, levels of cAMP and phosphorylated (p) cyclic-AMP response element binding protein (CREB) were up-regulated in the striatum and somatosensory cortex of Amph-treated WT mice, while similar to the saline-controls in the baclofen+Amph-treated group, indicating the blockade by baclofen to Amph.	Baclofen	299-307	cAMP responsive element binding protein 1	Mus musculus	109-113
16983645-5	2006	After the last treatment, levels of cAMP and phosphorylated (p) cyclic-AMP response element binding protein (CREB) were up-regulated in the striatum and somatosensory cortex of Amph-treated WT mice, while similar to the saline-controls in the baclofen+Amph-treated group, indicating the blockade by baclofen to Amph.	Amphetamine	252-256	cAMP responsive element binding protein 1	Mus musculus	109-113
16737738-4	2007	We observed that chronic exposure of mice to 50 ppm toluene for a longer period (12 weeks) caused a significant up-regulation of NMDA receptor subunit 2B (NMDA NR2B) expression associated with a simultaneous induction of CaMKIV, CREB-1, and FosB/DeltaFosB in the same hippocampal tissues.	Toluene	52-59	cAMP responsive element binding protein 1	Mus musculus	229-235
17143503-7	2007	Finally, TPA stimulated the activation of CREB and AP-1, but 6-MITC did not block TPA-induced COX-2 expression.	Tetradecanoylphorbol Acetate	9-12	cAMP responsive element binding protein 1	Mus musculus	42-46
16935438-5	2006	Chromatin immunoprecipitation (ChIP) assays show that CREB is recruited to the promoter region upon treatment of NS20Y cells with dibutyryl cAMP.	Cyclic AMP	140-144	cAMP responsive element binding protein 1	Mus musculus	54-58
16935438-6	2006	In addition, the production of ppN/OFQ mRNA is regulated by histone acetylation, also through CREB, as the histone deacetylase (HDAC) inhibitor trichostatin A increases both CREB binding to the promoter and ppN/OFQ mRNA expression.	trichostatin A	144-158	cAMP responsive element binding protein 1	Mus musculus	94-98
16935438-6	2006	In addition, the production of ppN/OFQ mRNA is regulated by histone acetylation, also through CREB, as the histone deacetylase (HDAC) inhibitor trichostatin A increases both CREB binding to the promoter and ppN/OFQ mRNA expression.	trichostatin A	144-158	cAMP responsive element binding protein 1	Mus musculus	174-178
16845490-14	2006	In addiction, PKA inhibitor H89 also inhibits c-Fos induction in 3T3-AR7 cells by ACTH(39), implicating activation of the cAMP/PKA/CREB pathway in c-Fos induction by ACTH(39).	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	28-31	cAMP responsive element binding protein 1	Mus musculus	131-135
16845490-14	2006	In addiction, PKA inhibitor H89 also inhibits c-Fos induction in 3T3-AR7 cells by ACTH(39), implicating activation of the cAMP/PKA/CREB pathway in c-Fos induction by ACTH(39).	Cyclic AMP	122-126	cAMP responsive element binding protein 1	Mus musculus	131-135
17050165-2	2006	HT22 cells resistant to glutamate displayed increased phosphorylation of cAMP-response-element binding (CREB) and decreased ERK1/2 suggestive of differences in signal transmission.	Glutamic Acid	24-33	cAMP responsive element binding protein 1	Mus musculus	104-108
16914643-7	2006	Furthermore, the significant increase in phosphorylated cAMP-response element binding protein (CREB) staining in ventral tegmental area induced by long-term morphine treatment was not evident in DKO mice, suggesting that CREB activation by morphine requires cAMP generated by AC1 and AC8.	Morphine	157-165	cAMP responsive element binding protein 1	Mus musculus	56-93
16914643-7	2006	Furthermore, the significant increase in phosphorylated cAMP-response element binding protein (CREB) staining in ventral tegmental area induced by long-term morphine treatment was not evident in DKO mice, suggesting that CREB activation by morphine requires cAMP generated by AC1 and AC8.	Morphine	240-248	cAMP responsive element binding protein 1	Mus musculus	221-225
16914643-7	2006	Furthermore, the significant increase in phosphorylated cAMP-response element binding protein (CREB) staining in ventral tegmental area induced by long-term morphine treatment was not evident in DKO mice, suggesting that CREB activation by morphine requires cAMP generated by AC1 and AC8.	Cyclic AMP	56-60	cAMP responsive element binding protein 1	Mus musculus	95-99
16914643-7	2006	Furthermore, the significant increase in phosphorylated cAMP-response element binding protein (CREB) staining in ventral tegmental area induced by long-term morphine treatment was not evident in DKO mice, suggesting that CREB activation by morphine requires cAMP generated by AC1 and AC8.	Cyclic AMP	56-60	cAMP responsive element binding protein 1	Mus musculus	221-225
16914643-7	2006	Furthermore, the significant increase in phosphorylated cAMP-response element binding protein (CREB) staining in ventral tegmental area induced by long-term morphine treatment was not evident in DKO mice, suggesting that CREB activation by morphine requires cAMP generated by AC1 and AC8.	Morphine	157-165	cAMP responsive element binding protein 1	Mus musculus	95-99
16914643-7	2006	Furthermore, the significant increase in phosphorylated cAMP-response element binding protein (CREB) staining in ventral tegmental area induced by long-term morphine treatment was not evident in DKO mice, suggesting that CREB activation by morphine requires cAMP generated by AC1 and AC8.	Morphine	157-165	cAMP responsive element binding protein 1	Mus musculus	221-225
16914643-7	2006	Furthermore, the significant increase in phosphorylated cAMP-response element binding protein (CREB) staining in ventral tegmental area induced by long-term morphine treatment was not evident in DKO mice, suggesting that CREB activation by morphine requires cAMP generated by AC1 and AC8.	Morphine	240-248	cAMP responsive element binding protein 1	Mus musculus	56-93
16914643-7	2006	Furthermore, the significant increase in phosphorylated cAMP-response element binding protein (CREB) staining in ventral tegmental area induced by long-term morphine treatment was not evident in DKO mice, suggesting that CREB activation by morphine requires cAMP generated by AC1 and AC8.	Morphine	240-248	cAMP responsive element binding protein 1	Mus musculus	95-99
16908541-4	2006	CBP phosphorylation disrupts CREB-CBP interaction and thus reduces nuclear cAMP action.	Cyclic AMP	75-79	cAMP responsive element binding protein 1	Mus musculus	29-33
16996475-8	2006	Analyses of PKC isoforms suggest that CREB phosphorylation is mediated by PKC epsilon translocating into nucleus only with TPA stimulation.	Tetradecanoylphorbol Acetate	123-126	cAMP responsive element binding protein 1	Mus musculus	38-42
17174385-8	2006	Moreover, phosphorylated cAMP response element-binding protein (CREB) and brain derived neurotrophic factor (BDNF) positive cell numbers were markedly increased in animals treated with oroxylin A than in untreated 2VO controls.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	185-195	cAMP responsive element binding protein 1	Mus musculus	25-62
17174385-8	2006	Moreover, phosphorylated cAMP response element-binding protein (CREB) and brain derived neurotrophic factor (BDNF) positive cell numbers were markedly increased in animals treated with oroxylin A than in untreated 2VO controls.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	185-195	cAMP responsive element binding protein 1	Mus musculus	64-68
17174385-9	2006	These results suggest that oroxylin A dramatically attenuates the memory impairment induced by 2VO, and that this effect may be mediated by the neuroprotective effects of oroxylin A as supported oroxylin A induced reductions in activated microglia and increases in BDNF expression and CREB phosphorylation.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	27-37	cAMP responsive element binding protein 1	Mus musculus	285-289
17174385-9	2006	These results suggest that oroxylin A dramatically attenuates the memory impairment induced by 2VO, and that this effect may be mediated by the neuroprotective effects of oroxylin A as supported oroxylin A induced reductions in activated microglia and increases in BDNF expression and CREB phosphorylation.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	171-181	cAMP responsive element binding protein 1	Mus musculus	285-289
17174385-9	2006	These results suggest that oroxylin A dramatically attenuates the memory impairment induced by 2VO, and that this effect may be mediated by the neuroprotective effects of oroxylin A as supported oroxylin A induced reductions in activated microglia and increases in BDNF expression and CREB phosphorylation.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	171-181	cAMP responsive element binding protein 1	Mus musculus	285-289
16981198-1	2006	cAMP response element binding protein (CREB) and the related factors CREM (cAMP response element modulator) and ATF1 (activation transcription factor 1) are bZIP-domain-containing transcription factors activated through cAMP and other signaling pathways.	Cyclic AMP	0-4	cAMP responsive element binding protein 1	Mus musculus	39-43
16908541-6	2006	In these mice, the CREB-CBP interaction is enhanced in both the absence and presence of cAMP stimulation.	Cyclic AMP	88-92	cAMP responsive element binding protein 1	Mus musculus	19-23
16780899-7	2006	The effects of papaverine on striatal cGMP and CREB and ERK phosphorylation, as well as on conditioned avoidance responding, were absent in PDE10A knockout mice, indicating that the effects of the compound are the result of PDE10A inhibition.	Papaverine	15-25	cAMP responsive element binding protein 1	Mus musculus	47-51
16908541-13	2006	In these beta cells, however, glucose-stimulated insulin secretion was diminished, resulting from concomitant CREB-CBP-mediated pgc1a gene activation.	Glucose	30-37	cAMP responsive element binding protein 1	Mus musculus	110-114
16901926-9	2006	Furthermore, TGFalpha increased phosphorylation of extracellular signal-regulated kinases 1/2 (ERK1/2) and cAMP-response element-binding protein (CREB), processes inhibited by the mitogen-activated protein kinase/ERK inhibitor U0126 and by expression of non-phosphorylatable CREB-M1 respectively.	U 0126	227-232	cAMP responsive element binding protein 1	Mus musculus	107-144
16901926-9	2006	Furthermore, TGFalpha increased phosphorylation of extracellular signal-regulated kinases 1/2 (ERK1/2) and cAMP-response element-binding protein (CREB), processes inhibited by the mitogen-activated protein kinase/ERK inhibitor U0126 and by expression of non-phosphorylatable CREB-M1 respectively.	U 0126	227-232	cAMP responsive element binding protein 1	Mus musculus	146-150
16901926-9	2006	Furthermore, TGFalpha increased phosphorylation of extracellular signal-regulated kinases 1/2 (ERK1/2) and cAMP-response element-binding protein (CREB), processes inhibited by the mitogen-activated protein kinase/ERK inhibitor U0126 and by expression of non-phosphorylatable CREB-M1 respectively.	U 0126	227-232	cAMP responsive element binding protein 1	Mus musculus	275-279
16971539-4	2006	Permanent zinc sulfate lesion of the olfactory epithelium resulted in a selective loss of the NMDA receptor NR2B protein and mRNA expression in pyramidal cells in layer IIb of PC after 2-7 d. Regulatory elements affected by NR2B signaling, namely the phosphorylation of CREB, were also downregulated only in layer IIb neurons.	Zinc Sulfate	10-22	cAMP responsive element binding protein 1	Mus musculus	270-274
16873684-0	2006	ERK1/2 control phosphorylation and protein level of cAMP-responsive element-binding protein: a key role in glucose-mediated pancreatic beta-cell survival.	Glucose	107-114	cAMP responsive element binding protein 1	Mus musculus	52-91
16873684-3	2006	We observed that 10 mmol/l glucose-induced CREB phosphorylation was totally inhibited by the protein kinase A (PKA) inhibitor H89 (2 micromol/l) and reduced by 50% with the extracellular signal-regulated kinase (ERK)1/2 inhibitor PD98059 (20 micromol/l).	Glucose	27-34	cAMP responsive element binding protein 1	Mus musculus	43-47
16873684-3	2006	We observed that 10 mmol/l glucose-induced CREB phosphorylation was totally inhibited by the protein kinase A (PKA) inhibitor H89 (2 micromol/l) and reduced by 50% with the extracellular signal-regulated kinase (ERK)1/2 inhibitor PD98059 (20 micromol/l).	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	126-129	cAMP responsive element binding protein 1	Mus musculus	43-47
16873684-3	2006	We observed that 10 mmol/l glucose-induced CREB phosphorylation was totally inhibited by the protein kinase A (PKA) inhibitor H89 (2 micromol/l) and reduced by 50% with the extracellular signal-regulated kinase (ERK)1/2 inhibitor PD98059 (20 micromol/l).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	230-237	cAMP responsive element binding protein 1	Mus musculus	43-47
16873684-4	2006	This indicates that ERK1/2, reported to be located downstream of PKA, participates in the PKA-mediated CREB phosphorylation elicited by glucose.	Glucose	136-143	cAMP responsive element binding protein 1	Mus musculus	103-107
16873684-5	2006	In ERK1/2-downregulated MIN6 cells by siRNA, glucose-stimulated CREB phosphorylation was highly reduced and CREB protein content was decreased by 60%.	Glucose	45-52	cAMP responsive element binding protein 1	Mus musculus	64-68
16873684-6	2006	In MIN6 cells and islets cultured for 24-48 h in optimal glucose concentration (10 mmol/l), which promotes survival, blockade of ERK1/2 activity with PD98059 caused a significant decrease in CREB protein level, whereas CREB mRNA remained unaffected (measured by real-time quantitative PCR).	Glucose	57-64	cAMP responsive element binding protein 1	Mus musculus	191-195
16873684-6	2006	In MIN6 cells and islets cultured for 24-48 h in optimal glucose concentration (10 mmol/l), which promotes survival, blockade of ERK1/2 activity with PD98059 caused a significant decrease in CREB protein level, whereas CREB mRNA remained unaffected (measured by real-time quantitative PCR).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	150-157	cAMP responsive element binding protein 1	Mus musculus	191-195
16873684-8	2006	Our results indicate that ERK1 and -2 control the phosphorylation and protein level of CREB and play a key role in glucose-mediated pancreatic beta-cell survival.	Glucose	115-122	cAMP responsive element binding protein 1	Mus musculus	87-91
16893419-6	2006	Surprisingly, this domain does not contain GATA-3 binding sites but possesses a binding motif, a cAMP response element (CRE), for the transcription factor, CREB.	Cyclic AMP	97-101	cAMP responsive element binding protein 1	Mus musculus	156-160
16882863-0	2006	CREB antisense oligodeoxynucleotide administration into the dorsal hippocampal CA3 region impairs long- but not short-term spatial memory in mice.	Oligodeoxyribonucleotides	15-35	cAMP responsive element binding protein 1	Mus musculus	0-4
16702214-1	2006	Incubation of 3T3-L1 preadipocytes with isobutylmethylxanthine (IBMX), dexamethasone, and insulin, alone or in combination, demonstrated that IBMX, which increased cAMP-response element-binding protein (CREB) phosphorylation, was the predominant regulator of Pde3b expression.	1-Methyl-3-isobutylxanthine	40-62	cAMP responsive element binding protein 1	Mus musculus	164-201
16702214-1	2006	Incubation of 3T3-L1 preadipocytes with isobutylmethylxanthine (IBMX), dexamethasone, and insulin, alone or in combination, demonstrated that IBMX, which increased cAMP-response element-binding protein (CREB) phosphorylation, was the predominant regulator of Pde3b expression.	1-Methyl-3-isobutylxanthine	40-62	cAMP responsive element binding protein 1	Mus musculus	203-207
16702214-1	2006	Incubation of 3T3-L1 preadipocytes with isobutylmethylxanthine (IBMX), dexamethasone, and insulin, alone or in combination, demonstrated that IBMX, which increased cAMP-response element-binding protein (CREB) phosphorylation, was the predominant regulator of Pde3b expression.	Dexamethasone	71-84	cAMP responsive element binding protein 1	Mus musculus	164-201
16702214-1	2006	Incubation of 3T3-L1 preadipocytes with isobutylmethylxanthine (IBMX), dexamethasone, and insulin, alone or in combination, demonstrated that IBMX, which increased cAMP-response element-binding protein (CREB) phosphorylation, was the predominant regulator of Pde3b expression.	Dexamethasone	71-84	cAMP responsive element binding protein 1	Mus musculus	203-207
16684769-8	2006	Although these were previously shown to activate Ca(2+)/cAMP-response element-binding protein (CREB)-dependent transcription, we here show that CL1 and CL2 were unable to significantly phosphorylate CREB Ser-133 and rather inhibited CRE-dependent gene expression by a dominant mechanism that bypassed CREB and was mediated by phosphorylated TORC2.	Cyclic AMP	56-60	cAMP responsive element binding protein 1	Mus musculus	95-99
16399875-6	2006	Enhanced cAMP signaling in parietal cells was confirmed by observation of hyperphosphorylation of the protein kinase A-regulated proteins LASP-1 and CREB.	Cyclic AMP	9-13	cAMP responsive element binding protein 1	Mus musculus	149-153
16621793-10	2006	Instead, total CREB and phospho-CREB (pCREB) were increased in the cytoplasm and decreased in the nucleus of 6-OHDA-treated cells.	Oxidopamine	109-115	cAMP responsive element binding protein 1	Mus musculus	15-19
16621793-10	2006	Instead, total CREB and phospho-CREB (pCREB) were increased in the cytoplasm and decreased in the nucleus of 6-OHDA-treated cells.	Oxidopamine	109-115	cAMP responsive element binding protein 1	Mus musculus	32-36
16785762-2	2006	The PKA signaling pathway plays an important role in protein secretion through the activation of cAMP, in fluid secretion through the elevation of intracellular calcium and in the activation of cAMP response element-binding protein (CREB), which is involved in these signaling cascades.	Cyclic AMP	97-101	cAMP responsive element binding protein 1	Mus musculus	233-237
16630062-3	2006	The increase in phosphorylated CREB expression observed in wild-type mice after chronic morphine was absent in CaMKIV-KO mice, while there was no difference in the expression or phosphorylation of the micro-opioid receptor between groups.	Morphine	88-96	cAMP responsive element binding protein 1	Mus musculus	31-35
16537646-8	2006	We also demonstrate that overexpression of two dominant negative mutants of the cAMP-response element-binding protein CREB (K-CREB and M1-CREB) and siRNA transfection, which disrupt the factor activity and expression, respectively, inhibit antimycin-A-induced triglyceride accumulation.	Cyclic AMP	80-84	cAMP responsive element binding protein 1	Mus musculus	135-142
16537646-8	2006	We also demonstrate that overexpression of two dominant negative mutants of the cAMP-response element-binding protein CREB (K-CREB and M1-CREB) and siRNA transfection, which disrupt the factor activity and expression, respectively, inhibit antimycin-A-induced triglyceride accumulation.	Antimycin A	240-251	cAMP responsive element binding protein 1	Mus musculus	118-122
16537646-8	2006	We also demonstrate that overexpression of two dominant negative mutants of the cAMP-response element-binding protein CREB (K-CREB and M1-CREB) and siRNA transfection, which disrupt the factor activity and expression, respectively, inhibit antimycin-A-induced triglyceride accumulation.	Antimycin A	240-251	cAMP responsive element binding protein 1	Mus musculus	135-142
16537646-8	2006	We also demonstrate that overexpression of two dominant negative mutants of the cAMP-response element-binding protein CREB (K-CREB and M1-CREB) and siRNA transfection, which disrupt the factor activity and expression, respectively, inhibit antimycin-A-induced triglyceride accumulation.	Triglycerides	260-272	cAMP responsive element binding protein 1	Mus musculus	118-122
16537646-8	2006	We also demonstrate that overexpression of two dominant negative mutants of the cAMP-response element-binding protein CREB (K-CREB and M1-CREB) and siRNA transfection, which disrupt the factor activity and expression, respectively, inhibit antimycin-A-induced triglyceride accumulation.	Triglycerides	260-272	cAMP responsive element binding protein 1	Mus musculus	135-142
16537646-9	2006	Furthermore, CREB knockdown with siRNA also downregulates the expression of several genes that contain cAMP-response element (CRE) sites in their promoter, among them one that is potentially involved in synthesis of triglycerides such as SCD1.	Cyclic AMP	103-107	cAMP responsive element binding protein 1	Mus musculus	13-17
16537646-9	2006	Furthermore, CREB knockdown with siRNA also downregulates the expression of several genes that contain cAMP-response element (CRE) sites in their promoter, among them one that is potentially involved in synthesis of triglycerides such as SCD1.	Triglycerides	216-229	cAMP responsive element binding protein 1	Mus musculus	13-17
16537646-10	2006	These results highlight a new role for CREB in the control of triglyceride metabolism during the adaptative response of preadipocytes to mitochondrial dysfunction.	Triglycerides	62-74	cAMP responsive element binding protein 1	Mus musculus	39-43
16373613-0	2006	Identification of the cAMP-responsive enhancer of the murine ABCA1 gene: requirement for CREB1 and STAT3/4 elements.	Cyclic AMP	22-26	cAMP responsive element binding protein 1	Mus musculus	89-94
16373613-7	2006	A dominant-negative CREB expression vector inhibited the cAMP induction of ABCA1, demonstrating that CREB was required for cAMP induction of ABCA1 expression in RAW264.7 cells.	Cyclic AMP	57-61	cAMP responsive element binding protein 1	Mus musculus	20-24
16373613-7	2006	A dominant-negative CREB expression vector inhibited the cAMP induction of ABCA1, demonstrating that CREB was required for cAMP induction of ABCA1 expression in RAW264.7 cells.	Cyclic AMP	57-61	cAMP responsive element binding protein 1	Mus musculus	101-105
16373613-7	2006	A dominant-negative CREB expression vector inhibited the cAMP induction of ABCA1, demonstrating that CREB was required for cAMP induction of ABCA1 expression in RAW264.7 cells.	Cyclic AMP	123-127	cAMP responsive element binding protein 1	Mus musculus	20-24
16373613-7	2006	A dominant-negative CREB expression vector inhibited the cAMP induction of ABCA1, demonstrating that CREB was required for cAMP induction of ABCA1 expression in RAW264.7 cells.	Cyclic AMP	123-127	cAMP responsive element binding protein 1	Mus musculus	101-105
16188363-6	2006	Electrophoretic mobility shift assay experiments demonstrated that CLA (100 microM) dramatically reduced activation of nuclear factor-kappaB (NF-kappaB), activator protein-1 (AP-1) and cAMP response element binding protein (CREB) induced by LPS/IFN-gamma.	Linoleic Acids, Conjugated	67-70	cAMP responsive element binding protein 1	Mus musculus	185-222
16188363-6	2006	Electrophoretic mobility shift assay experiments demonstrated that CLA (100 microM) dramatically reduced activation of nuclear factor-kappaB (NF-kappaB), activator protein-1 (AP-1) and cAMP response element binding protein (CREB) induced by LPS/IFN-gamma.	Linoleic Acids, Conjugated	67-70	cAMP responsive element binding protein 1	Mus musculus	224-228
16188363-8	2006	In summary, inhibition of NF-kappaB, AP-1 and CREB activation by CLA may be associated with the molecular basis for which CLA suppresses iNOS expression and NO production in stimulated mesangial cells.	Linoleic Acids, Conjugated	65-68	cAMP responsive element binding protein 1	Mus musculus	46-50
16188363-8	2006	In summary, inhibition of NF-kappaB, AP-1 and CREB activation by CLA may be associated with the molecular basis for which CLA suppresses iNOS expression and NO production in stimulated mesangial cells.	Linoleic Acids, Conjugated	122-125	cAMP responsive element binding protein 1	Mus musculus	46-50
16424113-0	2006	Docosahexaenoic acid consumption inhibits deoxynivalenol-induced CREB/ATF1 activation and IL-6 gene transcription in mouse macrophages.	Docosahexaenoic Acids	0-20	cAMP responsive element binding protein 1	Mus musculus	65-69
16424113-0	2006	Docosahexaenoic acid consumption inhibits deoxynivalenol-induced CREB/ATF1 activation and IL-6 gene transcription in mouse macrophages.	deoxynivalenol	42-56	cAMP responsive element binding protein 1	Mus musculus	65-69
16424113-5	2006	DON upregulated binding activity of cAMP response element binding protein (CREB) and activator protein (AP-1) to their respective consensus sequences in nuclear extracts from control-fed mice, whereas both activities were suppressed in nuclear extracts from DHA-fed mice.	deoxynivalenol	0-3	cAMP responsive element binding protein 1	Mus musculus	36-73
16519925-6	2006	Repeated treatment with antidepressant drugs, imipramine (Imi) and fluoxetine (Flu), significantly reduced the plasma corticosterone concentration and enhanced the BDNF and CREB levels.	Imipramine	46-56	cAMP responsive element binding protein 1	Mus musculus	173-177
16519925-6	2006	Repeated treatment with antidepressant drugs, imipramine (Imi) and fluoxetine (Flu), significantly reduced the plasma corticosterone concentration and enhanced the BDNF and CREB levels.	Imipramine	58-61	cAMP responsive element binding protein 1	Mus musculus	173-177
16519925-6	2006	Repeated treatment with antidepressant drugs, imipramine (Imi) and fluoxetine (Flu), significantly reduced the plasma corticosterone concentration and enhanced the BDNF and CREB levels.	Fluoxetine	67-77	cAMP responsive element binding protein 1	Mus musculus	173-177
16519925-6	2006	Repeated treatment with antidepressant drugs, imipramine (Imi) and fluoxetine (Flu), significantly reduced the plasma corticosterone concentration and enhanced the BDNF and CREB levels.	Fluoxetine	79-82	cAMP responsive element binding protein 1	Mus musculus	173-177
16427017-0	2006	A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons.	Nitric Oxide	2-14	cAMP responsive element binding protein 1	Mus musculus	42-46
16427017-5	2006	Instead, BDNF regulates CREB binding by initiating a nitric oxide-dependent signaling pathway that leads to S-nitrosylation of nuclear proteins that associate with CREB target genes.	Nitric Oxide	53-65	cAMP responsive element binding protein 1	Mus musculus	24-28
16427017-5	2006	Instead, BDNF regulates CREB binding by initiating a nitric oxide-dependent signaling pathway that leads to S-nitrosylation of nuclear proteins that associate with CREB target genes.	Nitric Oxide	53-65	cAMP responsive element binding protein 1	Mus musculus	164-168
16169938-9	2006	Investigation for possible mechanisms responsible for PEPCK suppression indicated that phosphorylation of cAMP-responsive element transcription factor (CREB) at Ser(133) was reduced remarkably by L803-mts, which was also associated with reduced phosphorylation at Ser(129) and no change in total CREB.	Cyclic AMP	106-110	cAMP responsive element binding protein 1	Mus musculus	152-156
16169938-9	2006	Investigation for possible mechanisms responsible for PEPCK suppression indicated that phosphorylation of cAMP-responsive element transcription factor (CREB) at Ser(133) was reduced remarkably by L803-mts, which was also associated with reduced phosphorylation at Ser(129) and no change in total CREB.	Cyclic AMP	106-110	cAMP responsive element binding protein 1	Mus musculus	296-300
16169938-9	2006	Investigation for possible mechanisms responsible for PEPCK suppression indicated that phosphorylation of cAMP-responsive element transcription factor (CREB) at Ser(133) was reduced remarkably by L803-mts, which was also associated with reduced phosphorylation at Ser(129) and no change in total CREB.	Serine	161-164	cAMP responsive element binding protein 1	Mus musculus	152-156
16169938-9	2006	Investigation for possible mechanisms responsible for PEPCK suppression indicated that phosphorylation of cAMP-responsive element transcription factor (CREB) at Ser(133) was reduced remarkably by L803-mts, which was also associated with reduced phosphorylation at Ser(129) and no change in total CREB.	Serine	161-164	cAMP responsive element binding protein 1	Mus musculus	296-300
16169938-9	2006	Investigation for possible mechanisms responsible for PEPCK suppression indicated that phosphorylation of cAMP-responsive element transcription factor (CREB) at Ser(133) was reduced remarkably by L803-mts, which was also associated with reduced phosphorylation at Ser(129) and no change in total CREB.	Serine	264-267	cAMP responsive element binding protein 1	Mus musculus	152-156
16611827-2	2006	To study whether estrogen has a nonclassical effect on basal forebrain cholinergic system, we measured the intensity of cAMP response element-binding protein (CREB) phosphorylation (pCREB) in cholinergic neurons after administration of 17beta-estradiol to ovariectomized (OVX) mice.	Estradiol	236-252	cAMP responsive element binding protein 1	Mus musculus	120-157
16611827-2	2006	To study whether estrogen has a nonclassical effect on basal forebrain cholinergic system, we measured the intensity of cAMP response element-binding protein (CREB) phosphorylation (pCREB) in cholinergic neurons after administration of 17beta-estradiol to ovariectomized (OVX) mice.	Estradiol	236-252	cAMP responsive element binding protein 1	Mus musculus	159-163
16537646-0	2006	CREB activation induced by mitochondrial dysfunction triggers triglyceride accumulation in 3T3-L1 preadipocytes.	Triglycerides	62-74	cAMP responsive element binding protein 1	Mus musculus	0-4
16537646-4	2006	We also show that treatment with antimycin A triggers CREB activation in these cells.	Antimycin A	33-44	cAMP responsive element binding protein 1	Mus musculus	54-58
16537646-8	2006	We also demonstrate that overexpression of two dominant negative mutants of the cAMP-response element-binding protein CREB (K-CREB and M1-CREB) and siRNA transfection, which disrupt the factor activity and expression, respectively, inhibit antimycin-A-induced triglyceride accumulation.	Cyclic AMP	80-84	cAMP responsive element binding protein 1	Mus musculus	118-122
16537646-8	2006	We also demonstrate that overexpression of two dominant negative mutants of the cAMP-response element-binding protein CREB (K-CREB and M1-CREB) and siRNA transfection, which disrupt the factor activity and expression, respectively, inhibit antimycin-A-induced triglyceride accumulation.	Cyclic AMP	80-84	cAMP responsive element binding protein 1	Mus musculus	126-130
16581769-4	2006	Consequently, NF-kappaB inhibition led to a decrease in forskolin-induced CREB phosphorylation.	Colforsin	56-65	cAMP responsive element binding protein 1	Mus musculus	74-78
16373613-8	2006	CONCLUSIONS: Phospho-CREB1 controls the cAMP-mediated induction of murine ABCA1 gene expression through a CRE site acting in cooperation with a nearby STAT element.	Cyclic AMP	40-44	cAMP responsive element binding protein 1	Mus musculus	21-26
16466739-8	2006	Finally, multiple transcription factors (AP-1, C/EBP, NF-kappaB and CREB) regulating the IL-6 gene are activated in response to isoproterenol stimulation, which may provide essential linkage between upstream cAMP-p38 MAPK signaling cascade and downstream IL-6 gene transcription.	Isoproterenol	128-141	cAMP responsive element binding protein 1	Mus musculus	68-72
16466739-8	2006	Finally, multiple transcription factors (AP-1, C/EBP, NF-kappaB and CREB) regulating the IL-6 gene are activated in response to isoproterenol stimulation, which may provide essential linkage between upstream cAMP-p38 MAPK signaling cascade and downstream IL-6 gene transcription.	Cyclic AMP	208-212	cAMP responsive element binding protein 1	Mus musculus	68-72
16300803-5	2006	Interestingly, however, acute LiCl treatment significantly reduced the phosphorylation of cAMP related element binding protein (CREB), a major intracellular target of trkB, in the HC.	Lithium Chloride	30-34	cAMP responsive element binding protein 1	Mus musculus	90-126
16300803-5	2006	Interestingly, however, acute LiCl treatment significantly reduced the phosphorylation of cAMP related element binding protein (CREB), a major intracellular target of trkB, in the HC.	Lithium Chloride	30-34	cAMP responsive element binding protein 1	Mus musculus	128-132
16300803-9	2006	The activation of CREB is, however, significantly reduced in the HC after acute LiCl treatment.	Lithium Chloride	80-84	cAMP responsive element binding protein 1	Mus musculus	18-22
16378594-4	2006	Cyclic AMP (cAMP) response element binding protein (CREB), a selective nuclear transcriptional factor, plays a key role in the neuronal functions.	Cyclic AMP	0-10	cAMP responsive element binding protein 1	Mus musculus	52-56
16378594-4	2006	Cyclic AMP (cAMP) response element binding protein (CREB), a selective nuclear transcriptional factor, plays a key role in the neuronal functions.	Cyclic AMP	12-16	cAMP responsive element binding protein 1	Mus musculus	52-56
16378594-5	2006	Phosphorylation of CREB on Ser-133 may facilitate its transcriptional activity in response to various stresses.	Serine	27-30	cAMP responsive element binding protein 1	Mus musculus	19-23
16378594-6	2006	In the current study, we observed the changes in CREB phosphorylation (Ser-133) and protein expression in the brain of auto-hypoxia-induced HPC mice by using Western blot analysis.	Serine	71-74	cAMP responsive element binding protein 1	Mus musculus	49-53
16378594-7	2006	We found that the levels of phosphorylated CREB (Ser-133), but not protein expression of CREB, increased significantly (p&lt;0.05) in the hippocampus and the frontal cortex of mice after repetitive hypoxic exposure (H2-H4, n=6 for each group), when compared to that of the normoxic (H0, n=6) or hypoxic exposure once group (H1, n=6).	Serine	49-52	cAMP responsive element binding protein 1	Mus musculus	43-47
16378594-8	2006	In addition, a significant enhancement (p&lt;0.05) of CREB phosphorylation (Ser-133) could also be found in the nuclear extracts from the whole hippocampus of hypoxic preconditioned mice (H2-H4, n=6 for each group).	Serine	76-79	cAMP responsive element binding protein 1	Mus musculus	54-58
16417577-0	2006	Galanin attenuates cyclic AMP regulatory element-binding protein (CREB) phosphorylation induced by chronic morphine and naloxone challenge in Cath.a cells and primary striatal cultures.	Cyclic AMP	19-29	cAMP responsive element binding protein 1	Mus musculus	66-70
16417577-0	2006	Galanin attenuates cyclic AMP regulatory element-binding protein (CREB) phosphorylation induced by chronic morphine and naloxone challenge in Cath.a cells and primary striatal cultures.	Morphine	107-115	cAMP responsive element binding protein 1	Mus musculus	66-70
16417577-0	2006	Galanin attenuates cyclic AMP regulatory element-binding protein (CREB) phosphorylation induced by chronic morphine and naloxone challenge in Cath.a cells and primary striatal cultures.	Naloxone	120-128	cAMP responsive element binding protein 1	Mus musculus	66-70
16417577-4	2006	The current study demonstrates that acute galanin treatment blocks the consequences of increased cAMP signaling following chronic opiate administration and withdrawal in Cath.a cells and primary cultures of striatal neurons as measured by phosphorylation of the transcription factor cAMP regulatory element-binding protein (CREB).	Cyclic AMP	97-101	cAMP responsive element binding protein 1	Mus musculus	283-322
16417577-4	2006	The current study demonstrates that acute galanin treatment blocks the consequences of increased cAMP signaling following chronic opiate administration and withdrawal in Cath.a cells and primary cultures of striatal neurons as measured by phosphorylation of the transcription factor cAMP regulatory element-binding protein (CREB).	Cyclic AMP	97-101	cAMP responsive element binding protein 1	Mus musculus	324-328
16424113-5	2006	DON upregulated binding activity of cAMP response element binding protein (CREB) and activator protein (AP-1) to their respective consensus sequences in nuclear extracts from control-fed mice, whereas both activities were suppressed in nuclear extracts from DHA-fed mice.	deoxynivalenol	0-3	cAMP responsive element binding protein 1	Mus musculus	75-79
16424113-6	2006	DON induced phosphorylation of CREB at Ser-133 and ATF1 at Ser-63 as well as intranuclear binding of phospho-CREB/ATF1 to the cis element of the IL-6 promoter in control macrophages, whereas both activities were inhibited in macrophages from DHA-fed mice.	deoxynivalenol	0-3	cAMP responsive element binding protein 1	Mus musculus	31-35
16424113-6	2006	DON induced phosphorylation of CREB at Ser-133 and ATF1 at Ser-63 as well as intranuclear binding of phospho-CREB/ATF1 to the cis element of the IL-6 promoter in control macrophages, whereas both activities were inhibited in macrophages from DHA-fed mice.	deoxynivalenol	0-3	cAMP responsive element binding protein 1	Mus musculus	109-113
16424113-6	2006	DON induced phosphorylation of CREB at Ser-133 and ATF1 at Ser-63 as well as intranuclear binding of phospho-CREB/ATF1 to the cis element of the IL-6 promoter in control macrophages, whereas both activities were inhibited in macrophages from DHA-fed mice.	Serine	39-42	cAMP responsive element binding protein 1	Mus musculus	31-35
16424113-7	2006	DHA consumption blocked DON-induced phosphorylation of the CREB kinase AKT.	Docosahexaenoic Acids	0-3	cAMP responsive element binding protein 1	Mus musculus	59-63
16424113-7	2006	DHA consumption blocked DON-induced phosphorylation of the CREB kinase AKT.	deoxynivalenol	24-27	cAMP responsive element binding protein 1	Mus musculus	59-63
16424113-9	2006	These data suggest that DHA consumption suppresses DON-induced IL-6 transcription in macrophages in part by interfering with AKT-dependent phosphorylation and subsequent binding of CREB/ATF1 to the IL-6 promoter.	Docosahexaenoic Acids	24-27	cAMP responsive element binding protein 1	Mus musculus	181-185
16424113-9	2006	These data suggest that DHA consumption suppresses DON-induced IL-6 transcription in macrophages in part by interfering with AKT-dependent phosphorylation and subsequent binding of CREB/ATF1 to the IL-6 promoter.	deoxynivalenol	51-54	cAMP responsive element binding protein 1	Mus musculus	181-185
16355270-17	2006	Conversely, FHL2 stimulation of CREB activity was dependent on integrin function because it was inhibited by Gly-Arg-Gly-Asp-Ser (GRGDS) peptide.	Glycyl-Arginine	109-116	cAMP responsive element binding protein 1	Mus musculus	32-36
16355270-17	2006	Conversely, FHL2 stimulation of CREB activity was dependent on integrin function because it was inhibited by Gly-Arg-Gly-Asp-Ser (GRGDS) peptide.	Glycine	109-112	cAMP responsive element binding protein 1	Mus musculus	32-36
16355270-17	2006	Conversely, FHL2 stimulation of CREB activity was dependent on integrin function because it was inhibited by Gly-Arg-Gly-Asp-Ser (GRGDS) peptide.	Aspartic Acid	121-124	cAMP responsive element binding protein 1	Mus musculus	32-36
16355270-17	2006	Conversely, FHL2 stimulation of CREB activity was dependent on integrin function because it was inhibited by Gly-Arg-Gly-Asp-Ser (GRGDS) peptide.	Serine	125-128	cAMP responsive element binding protein 1	Mus musculus	32-36
16785762-4	2006	METHODS: We examined CREB activation by assessing phosphorylation at the serine-133 position using Western blotting.	Serine	73-79	cAMP responsive element binding protein 1	Mus musculus	21-25
16785762-5	2006	RESULTS: Carbachol (a muscarinic acetylcholine agonist) and isoproterenol (a beta-adrenergic agonist) markedly activated CREB in parotid acinar cells.	Carbachol	9-18	cAMP responsive element binding protein 1	Mus musculus	121-125
16785762-5	2006	RESULTS: Carbachol (a muscarinic acetylcholine agonist) and isoproterenol (a beta-adrenergic agonist) markedly activated CREB in parotid acinar cells.	Acetylcholine	33-46	cAMP responsive element binding protein 1	Mus musculus	121-125
16785762-5	2006	RESULTS: Carbachol (a muscarinic acetylcholine agonist) and isoproterenol (a beta-adrenergic agonist) markedly activated CREB in parotid acinar cells.	Isoproterenol	60-73	cAMP responsive element binding protein 1	Mus musculus	121-125
16785762-6	2006	Carbachol and isoproterenol-induced CREB phosphorylation was blocked by atropine (a muscarinic acetylcholine antagonist) and propranolol (a beta-adrenergic antagonist), respectively.	Carbachol	0-9	cAMP responsive element binding protein 1	Mus musculus	36-40
16785762-6	2006	Carbachol and isoproterenol-induced CREB phosphorylation was blocked by atropine (a muscarinic acetylcholine antagonist) and propranolol (a beta-adrenergic antagonist), respectively.	Isoproterenol	14-27	cAMP responsive element binding protein 1	Mus musculus	36-40
16785762-6	2006	Carbachol and isoproterenol-induced CREB phosphorylation was blocked by atropine (a muscarinic acetylcholine antagonist) and propranolol (a beta-adrenergic antagonist), respectively.	Atropine	72-80	cAMP responsive element binding protein 1	Mus musculus	36-40
16785762-6	2006	Carbachol and isoproterenol-induced CREB phosphorylation was blocked by atropine (a muscarinic acetylcholine antagonist) and propranolol (a beta-adrenergic antagonist), respectively.	Acetylcholine	95-108	cAMP responsive element binding protein 1	Mus musculus	36-40
16785762-6	2006	Carbachol and isoproterenol-induced CREB phosphorylation was blocked by atropine (a muscarinic acetylcholine antagonist) and propranolol (a beta-adrenergic antagonist), respectively.	Propranolol	125-136	cAMP responsive element binding protein 1	Mus musculus	36-40
16785762-7	2006	The PKA inhibitor H89 inhibited CREB activation, but the PLC inhibitor U73122 did not.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	18-21	cAMP responsive element binding protein 1	Mus musculus	32-36
16785762-8	2006	Moreover, carbachol- and isoproterenol-stimulated amylase secretion from parotid acinar cells was inhibited by H89 and adenoviral dominant-negative CREB.	Carbachol	10-19	cAMP responsive element binding protein 1	Mus musculus	148-152
16785762-8	2006	Moreover, carbachol- and isoproterenol-stimulated amylase secretion from parotid acinar cells was inhibited by H89 and adenoviral dominant-negative CREB.	Isoproterenol	25-38	cAMP responsive element binding protein 1	Mus musculus	148-152
16313514-9	2005	These results suggest that AP-1 is an active regulator of the NR2B transcription and ethanol-induced changes may result at multiple levels in the regulation including AP-1 proteins expression, CREB phosphorylation and perhaps reorganization of dimmers.	Ethanol	85-92	cAMP responsive element binding protein 1	Mus musculus	193-197
16380431-3	2005	Here, we show that histone acetylation by the cAMP-response element binding protein (CREB)-binding protein (CBP) mediates sensitivity to cocaine by regulating expression of the fosB gene and its splice variant, DeltafosB, a transcription factor previously implicated in addiction.	Cocaine	137-144	cAMP responsive element binding protein 1	Mus musculus	46-83
16380431-3	2005	Here, we show that histone acetylation by the cAMP-response element binding protein (CREB)-binding protein (CBP) mediates sensitivity to cocaine by regulating expression of the fosB gene and its splice variant, DeltafosB, a transcription factor previously implicated in addiction.	Cocaine	137-144	cAMP responsive element binding protein 1	Mus musculus	85-89
16339038-4	2005	Cocaine-induced phosphorylation of MSK1 threonine 581 and cAMP response element-binding protein (CREB) serine 133 (Ser133) were blocked by SL327, a drug that prevents ERK activation.	Cocaine	0-7	cAMP responsive element binding protein 1	Mus musculus	58-95
16339038-4	2005	Cocaine-induced phosphorylation of MSK1 threonine 581 and cAMP response element-binding protein (CREB) serine 133 (Ser133) were blocked by SL327, a drug that prevents ERK activation.	Cocaine	0-7	cAMP responsive element binding protein 1	Mus musculus	97-101
16339038-4	2005	Cocaine-induced phosphorylation of MSK1 threonine 581 and cAMP response element-binding protein (CREB) serine 133 (Ser133) were blocked by SL327, a drug that prevents ERK activation.	Serine	103-109	cAMP responsive element binding protein 1	Mus musculus	58-95
16339038-4	2005	Cocaine-induced phosphorylation of MSK1 threonine 581 and cAMP response element-binding protein (CREB) serine 133 (Ser133) were blocked by SL327, a drug that prevents ERK activation.	Serine	103-109	cAMP responsive element binding protein 1	Mus musculus	97-101
16339038-6	2005	In MSK1 knock-out (KO) mice CREB and H3 phosphorylation in response to cocaine (10 mg/kg) were blocked, and induction of c-Fos and dynorphin was prevented, whereas the induction of Egr-1 (early growth response-1)/zif268/Krox24 was unaltered.	Cocaine	71-78	cAMP responsive element binding protein 1	Mus musculus	28-32
16313514-6	2005	The AP-1 DNA-binding complex in control and ethanol-treated nuclear extract was composed of c-Fos, FosB, c-Jun, JunD, and phosphorylated CREB (p-CREB).	Ethanol	44-51	cAMP responsive element binding protein 1	Mus musculus	137-141
16313514-6	2005	The AP-1 DNA-binding complex in control and ethanol-treated nuclear extract was composed of c-Fos, FosB, c-Jun, JunD, and phosphorylated CREB (p-CREB).	Ethanol	44-51	cAMP responsive element binding protein 1	Mus musculus	145-149
16313514-8	2005	The DNA affinity precipitation assay indicated that FosB, p-CREB, and c-Jun increased in the AP-1 complex following ethanol treatment.	Ethanol	116-123	cAMP responsive element binding protein 1	Mus musculus	60-64
16223607-5	2005	Collectively, the data indicate that Nnat enhances CREB phosphorylation through increasing intracellular free calcium levels, which potentiates expression of adipogenic transcription factors resulting in heightened adipocyte differentiation.	Calcium	110-117	cAMP responsive element binding protein 1	Mus musculus	51-55
16177237-0	2005	Methoxychlor inhibits brain mitochondrial respiration and increases hydrogen peroxide production and CREB phosphorylation.	Methoxychlor	0-12	cAMP responsive element binding protein 1	Mus musculus	101-105
16150701-6	2005	Downstream of Mapkapk2, CREB is phosphorylated on Ser(133) leading to its enhanced transcriptional activity.	Serine	50-53	cAMP responsive element binding protein 1	Mus musculus	24-28
16125054-6	2005	Activated p38 stimulated CREB-mediated transcription and potentiated the transcriptional strength of CREB provoked by forskolin.	Colforsin	118-127	cAMP responsive element binding protein 1	Mus musculus	101-105
16125054-0	2005	The cAMP signalling pathway activates CREB through PKA, p38 and MSK1 in NIH 3T3 cells.	Cyclic AMP	4-8	cAMP responsive element binding protein 1	Mus musculus	38-42
16197514-0	2005	Deletion of dopamine D1 and D3 receptors differentially affects spontaneous behaviour and cocaine-induced locomotor activity, reward and CREB phosphorylation.	Cocaine	90-97	cAMP responsive element binding protein 1	Mus musculus	137-141
16125054-1	2005	Cyclic adenosine 3",5"-monophosphate (cAMP) was originally shown to induce gene transcription through activation of cAMP-dependent protein kinase (PKA), and subsequent phosphorylation of the transcription factor cAMP response element-binding protein, CREB, at serine-133.	Cyclic AMP	0-36	cAMP responsive element binding protein 1	Mus musculus	251-255
16125054-1	2005	Cyclic adenosine 3",5"-monophosphate (cAMP) was originally shown to induce gene transcription through activation of cAMP-dependent protein kinase (PKA), and subsequent phosphorylation of the transcription factor cAMP response element-binding protein, CREB, at serine-133.	Cyclic AMP	38-42	cAMP responsive element binding protein 1	Mus musculus	251-255
16125054-1	2005	Cyclic adenosine 3",5"-monophosphate (cAMP) was originally shown to induce gene transcription through activation of cAMP-dependent protein kinase (PKA), and subsequent phosphorylation of the transcription factor cAMP response element-binding protein, CREB, at serine-133.	Cyclic AMP	116-120	cAMP responsive element binding protein 1	Mus musculus	251-255
16125054-2	2005	However, elevated cAMP levels may activate multiple signalling pathways with protein kinases that can phosphorylate CREB at serine-133.	Cyclic AMP	18-22	cAMP responsive element binding protein 1	Mus musculus	116-120
16125054-2	2005	However, elevated cAMP levels may activate multiple signalling pathways with protein kinases that can phosphorylate CREB at serine-133.	Serine	124-130	cAMP responsive element binding protein 1	Mus musculus	116-120
16125054-3	2005	We analysed the pathways involved in CREB phosphorylation and activation in NIH 3T3 cells exposed to the cAMP elevating agent forskolin.	Cyclic AMP	105-109	cAMP responsive element binding protein 1	Mus musculus	37-41
16125054-3	2005	We analysed the pathways involved in CREB phosphorylation and activation in NIH 3T3 cells exposed to the cAMP elevating agent forskolin.	Colforsin	126-135	cAMP responsive element binding protein 1	Mus musculus	37-41
16125054-6	2005	Activated p38 stimulated CREB-mediated transcription and potentiated the transcriptional strength of CREB provoked by forskolin.	Colforsin	118-127	cAMP responsive element binding protein 1	Mus musculus	25-29
16125054-8	2005	Our results suggest that forskolin-induced CREB phosphorylation and activation in NIH 3T3 cells is mediated directly by PKA and by a time-delayed PKA-dependent p38/MSK-1 pathway.	Colforsin	25-34	cAMP responsive element binding protein 1	Mus musculus	43-47
16105841-3	2005	Tax both stimulates the HTLV-I long terminal repeat and deregulates the expression of select cellular genes by altering the activity of specific host transcription factors, including cyclic AMP-responsive element-binding protein (CREB)/activating transcription factor, NF-kappaB/Rel, and serum response factor.	Cyclic AMP	183-193	cAMP responsive element binding protein 1	Mus musculus	230-234
15814901-3	2005	These observations were corroborated in MA-10 and mLTC-1 Leydig tumor cell lines, in which activation of PKC by phorbol-12-myristate-13-acetate (PMA, 10 nM) increased CREB phosphorylation and total StAR (tot-StAR) protein expression.	Tetradecanoylphorbol Acetate	112-143	cAMP responsive element binding protein 1	Mus musculus	167-171
15979729-3	2005	Further, we demonstrate that the inhibitory effects of ATP on NO production occur within 30 min of exposure and correlate with activation of the transcription factor CREB.	Adenosine Triphosphate	55-58	cAMP responsive element binding protein 1	Mus musculus	166-170
15979729-4	2005	Together, these data suggest that ATP may exert neuroprotective effects in the brain via a mechanism involving augmented activation of the p38/CREB pathway.	Adenosine Triphosphate	34-37	cAMP responsive element binding protein 1	Mus musculus	143-147
15963474-5	2005	Western blotting analysis indicated that delphinidin inhibited the degradation of IkappaB-alpha, nuclear translocation of p65 and CCAAT/enhancer-binding protein (C/EBP)delta and phosphorylation of c-Jun, but not CRE-binding protein (CREB).	delphinidin	41-52	cAMP responsive element binding protein 1	Mus musculus	212-231
15963474-5	2005	Western blotting analysis indicated that delphinidin inhibited the degradation of IkappaB-alpha, nuclear translocation of p65 and CCAAT/enhancer-binding protein (C/EBP)delta and phosphorylation of c-Jun, but not CRE-binding protein (CREB).	delphinidin	41-52	cAMP responsive element binding protein 1	Mus musculus	233-237
16164634-9	2005	Inhibition of ERK and CREB abrogates survival after 0.5 mmol/L H(2)O(2) treatment, while overexpression of CREB ameliorates necrotic death caused by 1 mmol/L H(2)O(2).	Hydrogen Peroxide	158-166	cAMP responsive element binding protein 1	Mus musculus	107-111
16164634-11	2005	Binding of phosphorylated CREB to a CREB oligonucleotide was significantly increased after 0.5 mmol/L H(2)O(2) but decreased after 1 mmol/L H(2)O(2).	Oligonucleotides	41-56	cAMP responsive element binding protein 1	Mus musculus	26-30
16164634-11	2005	Binding of phosphorylated CREB to a CREB oligonucleotide was significantly increased after 0.5 mmol/L H(2)O(2) but decreased after 1 mmol/L H(2)O(2).	Oligonucleotides	41-56	cAMP responsive element binding protein 1	Mus musculus	36-40
16164634-11	2005	Binding of phosphorylated CREB to a CREB oligonucleotide was significantly increased after 0.5 mmol/L H(2)O(2) but decreased after 1 mmol/L H(2)O(2).	Hydrogen Peroxide	102-110	cAMP responsive element binding protein 1	Mus musculus	26-30
16164634-11	2005	Binding of phosphorylated CREB to a CREB oligonucleotide was significantly increased after 0.5 mmol/L H(2)O(2) but decreased after 1 mmol/L H(2)O(2).	Hydrogen Peroxide	102-110	cAMP responsive element binding protein 1	Mus musculus	36-40
16164634-11	2005	Binding of phosphorylated CREB to a CREB oligonucleotide was significantly increased after 0.5 mmol/L H(2)O(2) but decreased after 1 mmol/L H(2)O(2).	Water	102-107	cAMP responsive element binding protein 1	Mus musculus	26-30
16164634-11	2005	Binding of phosphorylated CREB to a CREB oligonucleotide was significantly increased after 0.5 mmol/L H(2)O(2) but decreased after 1 mmol/L H(2)O(2).	Water	102-107	cAMP responsive element binding protein 1	Mus musculus	36-40
16164634-12	2005	Similarly, CREB-mediated transcription was significantly increased after 0.5 mmol/L H(2)O(2) treatment, while 1 mmol/L H(2)O(2) inhibited it.	Hydrogen Peroxide	84-92	cAMP responsive element binding protein 1	Mus musculus	11-15
16164634-13	2005	Interestingly, transcription from the CREB-driven bcl-2 promoter was unchanged after 0.5 mmol/L but decreased after 1 mmol/L H(2)O(2) treatment in agreement with Western blot studies.	Hydrogen Peroxide	125-133	cAMP responsive element binding protein 1	Mus musculus	38-42
15936220-1	2005	X-box-binding protein 1 (XBP-1) is a basic-region leucine zipper protein in the cyclic AMP response element binding protein/activating transcription factor (CREB/ATF) family of transcription factors involved in different cell-differentiation processes.	Cyclic AMP	80-90	cAMP responsive element binding protein 1	Mus musculus	157-161
15590637-4	2005	These results suggest that Hal may increase CREB phosphorylation and mPer1 expression according to the activation of the NMDA receptor through the dopaminergic pathways.	Haloperidol	27-30	cAMP responsive element binding protein 1	Mus musculus	44-48
15931667-4	2005	Intracellular cAMP increased due to LPS stimulation and the cAMP modulators phosphorylate transcription factor CREB, which is enhanced in turn by posttreatment with dbcAMP.	Cyclic AMP	14-18	cAMP responsive element binding protein 1	Mus musculus	111-115
15931667-4	2005	Intracellular cAMP increased due to LPS stimulation and the cAMP modulators phosphorylate transcription factor CREB, which is enhanced in turn by posttreatment with dbcAMP.	Cyclic AMP	60-64	cAMP responsive element binding protein 1	Mus musculus	111-115
15931667-4	2005	Intracellular cAMP increased due to LPS stimulation and the cAMP modulators phosphorylate transcription factor CREB, which is enhanced in turn by posttreatment with dbcAMP.	Bucladesine	165-171	cAMP responsive element binding protein 1	Mus musculus	111-115
15931667-5	2005	In contrast, the Epac-specific cAMP analog 8-(4-chloro-phenylthio)-2"-O-methyladenosine-3",5"-cyclic monophosphate (8CPT-2Me-cAMP) activates Rap1 in the BV2 cells, but does not induce PKA activation, as judged by CREB phosphorylation.	Cyclic AMP	31-35	cAMP responsive element binding protein 1	Mus musculus	213-217
15931667-5	2005	In contrast, the Epac-specific cAMP analog 8-(4-chloro-phenylthio)-2"-O-methyladenosine-3",5"-cyclic monophosphate (8CPT-2Me-cAMP) activates Rap1 in the BV2 cells, but does not induce PKA activation, as judged by CREB phosphorylation.	8-(4-chloro-phenylthio)-2'-O-methyladenosine-3'-5'-cyclic monophosphate	43-114	cAMP responsive element binding protein 1	Mus musculus	213-217
15931667-5	2005	In contrast, the Epac-specific cAMP analog 8-(4-chloro-phenylthio)-2"-O-methyladenosine-3",5"-cyclic monophosphate (8CPT-2Me-cAMP) activates Rap1 in the BV2 cells, but does not induce PKA activation, as judged by CREB phosphorylation.	8cpt-2me-camp	116-129	cAMP responsive element binding protein 1	Mus musculus	213-217
15774772-0	2005	Potential role of cAMP response element-binding protein in ethanol-induced N-methyl-D-aspartate receptor 2B subunit gene transcription in fetal mouse cortical cells.	Ethanol	59-66	cAMP responsive element binding protein 1	Mus musculus	18-55
15774772-3	2005	We find a significant increase in phosphorylated CREB, without change in total CREB protein, in cells treated with ethanol for 5 days.	Ethanol	115-122	cAMP responsive element binding protein 1	Mus musculus	49-53
15774772-3	2005	We find a significant increase in phosphorylated CREB, without change in total CREB protein, in cells treated with ethanol for 5 days.	Ethanol	115-122	cAMP responsive element binding protein 1	Mus musculus	79-83
15774772-5	2005	CREB phosphorylation was increased by ethanol treatment in both media, irrespective of the presence of serum.	Ethanol	38-45	cAMP responsive element binding protein 1	Mus musculus	0-4
15831817-9	2005	Taken together, these results suggest that AdE4+ may play an important role in the regulation of Cx expression in ECs, and that these effects are mediated by both the PKA/CREB and PI3K signaling pathways.	ade4+	43-48	cAMP responsive element binding protein 1	Mus musculus	171-175
15653713-0	2005	Ethanol stimulates the expression of fibronectin in lung fibroblasts via kinase-dependent signals that activate CREB.	Ethanol	0-7	cAMP responsive element binding protein 1	Mus musculus	112-116
15855635-7	2005	In dominant-negative CREB-transfected cells, dibutyryl cAMP no longer prevented cell injury or inhibited changes in mRNA expression of Bcl-2 and Bax.	dibutyryl	45-54	cAMP responsive element binding protein 1	Mus musculus	21-25
15855635-7	2005	In dominant-negative CREB-transfected cells, dibutyryl cAMP no longer prevented cell injury or inhibited changes in mRNA expression of Bcl-2 and Bax.	Cyclic AMP	55-59	cAMP responsive element binding protein 1	Mus musculus	21-25
15855635-10	2005	These findings suggest that elevation of endogenous cAMP effectively prevents radiocontrast nephropathy through activation of A kinase/PI 3-kinase/Akt followed by CREB phosphorylation and enhanced expression of Bcl-2.	Cyclic AMP	52-56	cAMP responsive element binding protein 1	Mus musculus	163-167
15769622-6	2005	However, some effects of cGMP can be directly attributed to cGMP regulation of specific transcription factors such as CREB, TFII-I or c-Fos, and are mediated by cGMP-dependent protein kinases.	Cyclic GMP	25-29	cAMP responsive element binding protein 1	Mus musculus	118-122
15769622-6	2005	However, some effects of cGMP can be directly attributed to cGMP regulation of specific transcription factors such as CREB, TFII-I or c-Fos, and are mediated by cGMP-dependent protein kinases.	Cyclic GMP	60-64	cAMP responsive element binding protein 1	Mus musculus	118-122
15836624-2	2005	The phosphorylation of cAMP-responsive element binding protein (CREB) and induction of c-Fos in response to cAMP were strongly suppressed in Neuro2a cells expressing expanded polyglutamine.	Cyclic AMP	23-27	cAMP responsive element binding protein 1	Mus musculus	64-68
15836624-2	2005	The phosphorylation of cAMP-responsive element binding protein (CREB) and induction of c-Fos in response to cAMP were strongly suppressed in Neuro2a cells expressing expanded polyglutamine.	polyglutamine	175-188	cAMP responsive element binding protein 1	Mus musculus	23-62
15836624-2	2005	The phosphorylation of cAMP-responsive element binding protein (CREB) and induction of c-Fos in response to cAMP were strongly suppressed in Neuro2a cells expressing expanded polyglutamine.	polyglutamine	175-188	cAMP responsive element binding protein 1	Mus musculus	64-68
15836624-3	2005	The suppression of CREB-dependent transcriptional activation was reversibly rescued by increasing the concentration of cAMP.	Cyclic AMP	119-123	cAMP responsive element binding protein 1	Mus musculus	19-23
15836624-4	2005	Expanded polyglutamine-induced cytotoxicity was also substantially suppressed by augmenting CREB-dependent transcriptional activation with a high concentration of cAMP.	polyglutamine	9-22	cAMP responsive element binding protein 1	Mus musculus	92-96
15836624-4	2005	Expanded polyglutamine-induced cytotoxicity was also substantially suppressed by augmenting CREB-dependent transcriptional activation with a high concentration of cAMP.	Cyclic AMP	163-167	cAMP responsive element binding protein 1	Mus musculus	92-96
15836624-5	2005	FR901228, a histone deacetylase inhibitor, was also demonstrated as rescuing the expanded polyglutamine-induced suppression of CREB phosphorylation and c-Fos expression.	romidepsin	0-8	cAMP responsive element binding protein 1	Mus musculus	127-131
15836624-5	2005	FR901228, a histone deacetylase inhibitor, was also demonstrated as rescuing the expanded polyglutamine-induced suppression of CREB phosphorylation and c-Fos expression.	polyglutamine	90-103	cAMP responsive element binding protein 1	Mus musculus	127-131
15836624-7	2005	The co-expression of dominant-negative CREB vectors considerably abrogated the suppressive effect of cAMP and FR901228 on the expanded polyglutamine-induced nuclear fragmentation, suggesting that these compounds suppress polyglutamine-induced cytotoxicity, largely, via the enhancement of CREB-dependent transcriptional activation.	Cyclic AMP	101-105	cAMP responsive element binding protein 1	Mus musculus	39-43
15836624-7	2005	The co-expression of dominant-negative CREB vectors considerably abrogated the suppressive effect of cAMP and FR901228 on the expanded polyglutamine-induced nuclear fragmentation, suggesting that these compounds suppress polyglutamine-induced cytotoxicity, largely, via the enhancement of CREB-dependent transcriptional activation.	Cyclic AMP	101-105	cAMP responsive element binding protein 1	Mus musculus	289-293
15836624-7	2005	The co-expression of dominant-negative CREB vectors considerably abrogated the suppressive effect of cAMP and FR901228 on the expanded polyglutamine-induced nuclear fragmentation, suggesting that these compounds suppress polyglutamine-induced cytotoxicity, largely, via the enhancement of CREB-dependent transcriptional activation.	romidepsin	110-118	cAMP responsive element binding protein 1	Mus musculus	39-43
15836624-7	2005	The co-expression of dominant-negative CREB vectors considerably abrogated the suppressive effect of cAMP and FR901228 on the expanded polyglutamine-induced nuclear fragmentation, suggesting that these compounds suppress polyglutamine-induced cytotoxicity, largely, via the enhancement of CREB-dependent transcriptional activation.	romidepsin	110-118	cAMP responsive element binding protein 1	Mus musculus	289-293
15836624-7	2005	The co-expression of dominant-negative CREB vectors considerably abrogated the suppressive effect of cAMP and FR901228 on the expanded polyglutamine-induced nuclear fragmentation, suggesting that these compounds suppress polyglutamine-induced cytotoxicity, largely, via the enhancement of CREB-dependent transcriptional activation.	polyglutamine	135-148	cAMP responsive element binding protein 1	Mus musculus	39-43
15836624-7	2005	The co-expression of dominant-negative CREB vectors considerably abrogated the suppressive effect of cAMP and FR901228 on the expanded polyglutamine-induced nuclear fragmentation, suggesting that these compounds suppress polyglutamine-induced cytotoxicity, largely, via the enhancement of CREB-dependent transcriptional activation.	polyglutamine	135-148	cAMP responsive element binding protein 1	Mus musculus	289-293
15836624-7	2005	The co-expression of dominant-negative CREB vectors considerably abrogated the suppressive effect of cAMP and FR901228 on the expanded polyglutamine-induced nuclear fragmentation, suggesting that these compounds suppress polyglutamine-induced cytotoxicity, largely, via the enhancement of CREB-dependent transcriptional activation.	polyglutamine	221-234	cAMP responsive element binding protein 1	Mus musculus	39-43
15836624-7	2005	The co-expression of dominant-negative CREB vectors considerably abrogated the suppressive effect of cAMP and FR901228 on the expanded polyglutamine-induced nuclear fragmentation, suggesting that these compounds suppress polyglutamine-induced cytotoxicity, largely, via the enhancement of CREB-dependent transcriptional activation.	polyglutamine	221-234	cAMP responsive element binding protein 1	Mus musculus	289-293
15836624-8	2005	These findings suggest that the interference of CREB-dependent transcriptional activation by expanded polyglutamine stretches is involved in the pathogenetic mechanisms underlying neurodegeneration, and that the augmentation of CREB-dependent transcriptional activation is a potential strategy in treating polyglutamine diseases.	polyglutamine	102-115	cAMP responsive element binding protein 1	Mus musculus	48-52
15836624-8	2005	These findings suggest that the interference of CREB-dependent transcriptional activation by expanded polyglutamine stretches is involved in the pathogenetic mechanisms underlying neurodegeneration, and that the augmentation of CREB-dependent transcriptional activation is a potential strategy in treating polyglutamine diseases.	polyglutamine	102-115	cAMP responsive element binding protein 1	Mus musculus	228-232
15647252-5	2005	The activation of the Pkhd1 promoter by wild-type HNF-1beta is stimulated by sodium butyrate or coactivators CREB (cAMP-response element)-binding protein (CBP) and P/CAF.	Cyclic AMP	115-119	cAMP responsive element binding protein 1	Mus musculus	109-113
16046859-0	2005	Augmented constitutive CREB expression in the nucleus accumbens and striatum may contribute to the altered behavioral response to cocaine of adult mice exposed to cocaine in utero.	Cocaine	130-137	cAMP responsive element binding protein 1	Mus musculus	23-27
16046859-0	2005	Augmented constitutive CREB expression in the nucleus accumbens and striatum may contribute to the altered behavioral response to cocaine of adult mice exposed to cocaine in utero.	Cocaine	163-170	cAMP responsive element binding protein 1	Mus musculus	23-27
16046859-9	2005	Such alterations in constitutive CREB levels may contribute to some of the behavioral differences reported in adult mice exposed to cocaine in utero.	Cocaine	132-139	cAMP responsive element binding protein 1	Mus musculus	33-37
15569686-1	2005	The transcriptional activation mediated by cAMP-response element (CRE) and transcription factors of the CRE-binding protein (CREB)/CRE modulator (CREM) family represents an important mechanism of cAMP-dependent gene regulation possibly implicated in detrimental effects of chronic beta-adrenergic stimulation in end-stage heart failure.	Cyclic AMP	43-47	cAMP responsive element binding protein 1	Mus musculus	104-123
15569686-1	2005	The transcriptional activation mediated by cAMP-response element (CRE) and transcription factors of the CRE-binding protein (CREB)/CRE modulator (CREM) family represents an important mechanism of cAMP-dependent gene regulation possibly implicated in detrimental effects of chronic beta-adrenergic stimulation in end-stage heart failure.	Cyclic AMP	43-47	cAMP responsive element binding protein 1	Mus musculus	125-129
15569686-1	2005	The transcriptional activation mediated by cAMP-response element (CRE) and transcription factors of the CRE-binding protein (CREB)/CRE modulator (CREM) family represents an important mechanism of cAMP-dependent gene regulation possibly implicated in detrimental effects of chronic beta-adrenergic stimulation in end-stage heart failure.	Cyclic AMP	196-200	cAMP responsive element binding protein 1	Mus musculus	104-123
15569686-1	2005	The transcriptional activation mediated by cAMP-response element (CRE) and transcription factors of the CRE-binding protein (CREB)/CRE modulator (CREM) family represents an important mechanism of cAMP-dependent gene regulation possibly implicated in detrimental effects of chronic beta-adrenergic stimulation in end-stage heart failure.	Cyclic AMP	196-200	cAMP responsive element binding protein 1	Mus musculus	125-129
15953421-0	2005	Mu-opioid receptor and CREB activation are required for nicotine reward.	Nicotine	56-64	cAMP responsive element binding protein 1	Mus musculus	23-27
15953421-2	2005	Exposure to an environment previously associated with rewarding properties of nicotine results in an increase of CREB phosphorylation similar to that seen following nicotine administration, and this response is absent in MOR(-/-) mice.	Nicotine	78-86	cAMP responsive element binding protein 1	Mus musculus	113-117
15953421-3	2005	Moreover, a single administration of an opioid receptor antagonist, naloxone, blocks both the conditioned molecular response (CREB phosphorylation) and the conditioned behavioral response (nicotine reward) in a place preference paradigm.	Naloxone	68-76	cAMP responsive element binding protein 1	Mus musculus	126-130
15953421-5	2005	However, this effect, along with rewarding properties of nicotine, is blocked in mice with a targeted disruption in the CREB gene.	Nicotine	57-65	cAMP responsive element binding protein 1	Mus musculus	120-124
15953421-6	2005	Together, pharmacologic and genetic manipulations indicate that phosphorylation of CREB and upregulation of functional MORs are required for nicotine-conditioned reward.	Nicotine	141-149	cAMP responsive element binding protein 1	Mus musculus	83-87
15880467-1	2005	We have directed a polyclonal antibody against an oligo-peptide (123-136) of the transcription factor cyclic AMP responsive element-binding protein (CREB) including the serine residue at 133.	Serine	169-175	cAMP responsive element binding protein 1	Mus musculus	102-147
15880467-1	2005	We have directed a polyclonal antibody against an oligo-peptide (123-136) of the transcription factor cyclic AMP responsive element-binding protein (CREB) including the serine residue at 133.	Serine	169-175	cAMP responsive element binding protein 1	Mus musculus	149-153
15774772-9	2005	Our results indicate that CREB is probably involved in mediating ethanol-induced up-regulation of NR2B gene.	Ethanol	65-72	cAMP responsive element binding protein 1	Mus musculus	26-30
15855635-5	2005	Dibutyryl cAMP increased phosphorylation of Akt and CREB, both of which were reversed by H89, wortmannin and the Akt inhibitor SH-6.	Cyclic AMP	10-14	cAMP responsive element binding protein 1	Mus musculus	52-56
15855635-5	2005	Dibutyryl cAMP increased phosphorylation of Akt and CREB, both of which were reversed by H89, wortmannin and the Akt inhibitor SH-6.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	89-92	cAMP responsive element binding protein 1	Mus musculus	52-56
15855635-5	2005	Dibutyryl cAMP increased phosphorylation of Akt and CREB, both of which were reversed by H89, wortmannin and the Akt inhibitor SH-6.	Wortmannin	94-104	cAMP responsive element binding protein 1	Mus musculus	52-56
15855635-5	2005	Dibutyryl cAMP increased phosphorylation of Akt and CREB, both of which were reversed by H89, wortmannin and the Akt inhibitor SH-6.	sanguiin H 6	127-131	cAMP responsive element binding protein 1	Mus musculus	52-56
15836624-0	2005	Interference of CREB-dependent transcriptional activation by expanded polyglutamine stretches--augmentation of transcriptional activation as a potential therapeutic strategy for polyglutamine diseases.	polyglutamine	70-83	cAMP responsive element binding protein 1	Mus musculus	16-20
15731115-4	2005	Further analysis revealed that ROS promoted phosphorylation of cAMP response element-binding protein (CREB)/ATF2 and its binding to CRE-domain in the murine RANKL promoter region.	Reactive Oxygen Species	31-34	cAMP responsive element binding protein 1	Mus musculus	63-100
15731115-4	2005	Further analysis revealed that ROS promoted phosphorylation of cAMP response element-binding protein (CREB)/ATF2 and its binding to CRE-domain in the murine RANKL promoter region.	Reactive Oxygen Species	31-34	cAMP responsive element binding protein 1	Mus musculus	102-106
15731115-5	2005	Moreover, the results of protein kinase A (PKA) inhibitor KT5720 and CREB1 RNA interference transfection clearly showed that PKA-CREB signaling pathway was necessary for ROS stimulation of RANKL in mouse osteoblasts.	Reactive Oxygen Species	170-173	cAMP responsive element binding protein 1	Mus musculus	69-74
15731115-5	2005	Moreover, the results of protein kinase A (PKA) inhibitor KT5720 and CREB1 RNA interference transfection clearly showed that PKA-CREB signaling pathway was necessary for ROS stimulation of RANKL in mouse osteoblasts.	Reactive Oxygen Species	170-173	cAMP responsive element binding protein 1	Mus musculus	69-73
15731115-8	2005	These results demonstrate that ROS stimulates RANKL expression via ERKs and PKA-CREB pathway in mouse osteoblasts and via ERKs and HSF2 in human MG63 cells.	Reactive Oxygen Species	31-34	cAMP responsive element binding protein 1	Mus musculus	80-84
15550512-0	2005	Cyclic adenosine 3",5"-monophosphate (cAMP) enhances cAMP-responsive element binding (CREB) protein phosphorylation and phospho-CREB interaction with the mouse steroidogenic acute regulatory protein gene promoter.	Cyclic AMP	0-36	cAMP responsive element binding protein 1	Mus musculus	86-90
15550512-0	2005	Cyclic adenosine 3",5"-monophosphate (cAMP) enhances cAMP-responsive element binding (CREB) protein phosphorylation and phospho-CREB interaction with the mouse steroidogenic acute regulatory protein gene promoter.	Cyclic AMP	0-36	cAMP responsive element binding protein 1	Mus musculus	128-132
15550512-0	2005	Cyclic adenosine 3",5"-monophosphate (cAMP) enhances cAMP-responsive element binding (CREB) protein phosphorylation and phospho-CREB interaction with the mouse steroidogenic acute regulatory protein gene promoter.	Cyclic AMP	38-42	cAMP responsive element binding protein 1	Mus musculus	86-90
15550512-0	2005	Cyclic adenosine 3",5"-monophosphate (cAMP) enhances cAMP-responsive element binding (CREB) protein phosphorylation and phospho-CREB interaction with the mouse steroidogenic acute regulatory protein gene promoter.	Cyclic AMP	38-42	cAMP responsive element binding protein 1	Mus musculus	128-132
15550512-0	2005	Cyclic adenosine 3",5"-monophosphate (cAMP) enhances cAMP-responsive element binding (CREB) protein phosphorylation and phospho-CREB interaction with the mouse steroidogenic acute regulatory protein gene promoter.	Cyclic AMP	53-57	cAMP responsive element binding protein 1	Mus musculus	86-90
15550512-2	2005	Classically, binding of phosphorylated CREB to cis-acting cAMP-responsive elements (5"-TGACGTCA-3") within target gene promoters leads to recruitment of the coactivator CREB binding protein (CBP).	Cyclic AMP	58-62	cAMP responsive element binding protein 1	Mus musculus	39-43
15550512-6	2005	Using DNA-affinity chromatography, we now show that CREB and ATF-1, but not CREM, interact with the StAR promoter, and this interaction is dependent on the activator protein-1 (AP-1) cis-acting element within the cAMP-responsive region.	Cyclic AMP	213-217	cAMP responsive element binding protein 1	Mus musculus	52-56
15550512-9	2005	However, (Bu)2cAMP-treatment increased P-CREB and CBP interaction with the StAR promoter, demonstrating for the first time the physical role of P-CREB:DNA interactions in CBP recruitment to the StAR proximal promoter.	2camp	13-18	cAMP responsive element binding protein 1	Mus musculus	41-45
15550512-9	2005	However, (Bu)2cAMP-treatment increased P-CREB and CBP interaction with the StAR promoter, demonstrating for the first time the physical role of P-CREB:DNA interactions in CBP recruitment to the StAR proximal promoter.	2camp	13-18	cAMP responsive element binding protein 1	Mus musculus	146-150
15714041-0	2005	CREB gene transcription factors: role in molecular mechanisms of alcohol and drug addiction.	Alcohols	65-72	cAMP responsive element binding protein 1	Mus musculus	0-4
15714041-3	2005	The presentations were (1) Ethanol Modulation of CREB: Role in Dependence and Withdrawal, by Fulton Crews; (2) Effects of D1 Dopamine Receptor Activation During Withdrawal From Chronic Morphine: Enhanced CREB Activation and Decreased Conditioned Place Aversion, by Elena H. Chartoff; (3) CREB-Haplodeficient Mice: Role in Anxiety and Alcohol-Drinking Behaviors, by Subhash C. Pandey; and (4) A Role for CREB in Stress and Drug Addiction, by Julie A. Blendy.	Ethanol	27-34	cAMP responsive element binding protein 1	Mus musculus	49-53
15639337-10	2005	In another study, topical application of TPA induced DNA binding of cyclic AMP response element binding (CREB) protein in mouse skin in vivo, which was abrogated by pretreatment with either CB or DC.	Tetradecanoylphorbol Acetate	41-44	cAMP responsive element binding protein 1	Mus musculus	105-109
15639337-2	2005	on phorbol ester-induced COX-2 expression in mouse skin: AP-1 and CREB as potential upstream targets.	Phorbol Esters	3-16	cAMP responsive element binding protein 1	Mus musculus	66-70
15523052-5	2005	cAMP response element-binding protein (CREB)-binding protein (CBP) that interacts preferentially with the phosphorylated-CREB increased the cAMP-induced FUER.	Cyclic AMP	0-4	cAMP responsive element binding protein 1	Mus musculus	121-125
15639337-10	2005	In another study, topical application of TPA induced DNA binding of cyclic AMP response element binding (CREB) protein in mouse skin in vivo, which was abrogated by pretreatment with either CB or DC.	Cyclic AMP	68-78	cAMP responsive element binding protein 1	Mus musculus	105-109
15680959-5	2005	Morphine-induced thermoregulation is attenuated in CREB(alphaDelta) mutant mice at high doses of morphine compared to wild type animals.	Morphine	97-105	cAMP responsive element binding protein 1	Mus musculus	51-55
15680959-6	2005	The behavioral differences in response to morphine seen in CREB(alphaDelta) mutant mice are not due to changes in mu opioid receptor (MOR) mRNA expression, as the CREB deletion has no effect on baseline MOR mRNA in three of the brain regions involved in mediating these behaviors: the ventral tegmental area (VTA), nucleus accumbens (NAc), and hypothalamus.	Morphine	42-50	cAMP responsive element binding protein 1	Mus musculus	59-63
15680959-7	2005	These data demonstrate that at low doses, deficits in morphine-induced changes in CREB deficient mice are limited to reward and thermoregulation.	Morphine	54-62	cAMP responsive element binding protein 1	Mus musculus	82-86
15680959-0	2005	Alterations in morphine-induced reward, locomotor activity, and thermoregulation in CREB-deficient mice.	Morphine	15-23	cAMP responsive element binding protein 1	Mus musculus	84-88
15680959-8	2005	However, at higher doses, CREB mutant mice actually find morphine more rewarding and exhibit increased locomotor activity compared to their wild type littermates.	Morphine	57-65	cAMP responsive element binding protein 1	Mus musculus	26-30
15680959-1	2005	Previous studies in our lab have shown a robust decrease in the rewarding properties of morphine in CREB(alphaDelta) mutant mice.	Morphine	88-96	cAMP responsive element binding protein 1	Mus musculus	100-104
15680959-9	2005	Together, these results indicate that the role of CREB in dose-dependent changes in behaviors induced by morphine is different depending on the brain regions involved in mediating the behavior.	Morphine	105-113	cAMP responsive element binding protein 1	Mus musculus	50-54
15680959-3	2005	At low doses of morphine (5 and 10 mg/kg), CREB(alphaDelta) mutant mice show a reduction in reward yet similar locomotor activity in response to morphine compared to wild type littermates.	Morphine	16-24	cAMP responsive element binding protein 1	Mus musculus	43-47
15663480-0	2005	Role of basic region leucine zipper transcription factors cyclic AMP response element binding protein (CREB), CREB2, activating transcription factor 2 and CAAT/enhancer binding protein alpha in cyclic AMP response element-mediated transcription.	Cyclic AMP	194-204	cAMP responsive element binding protein 1	Mus musculus	103-107
15680959-3	2005	At low doses of morphine (5 and 10 mg/kg), CREB(alphaDelta) mutant mice show a reduction in reward yet similar locomotor activity in response to morphine compared to wild type littermates.	Morphine	145-153	cAMP responsive element binding protein 1	Mus musculus	43-47
15680959-5	2005	Morphine-induced thermoregulation is attenuated in CREB(alphaDelta) mutant mice at high doses of morphine compared to wild type animals.	Morphine	0-8	cAMP responsive element binding protein 1	Mus musculus	51-55
15589507-6	2005	In addition, DNA binding activities of nuclear factor-kappaB (NF-kappaB) and CREB in both brain regions and SP-1 in the hippocampus were more pronounced in mice injected with Tat plus EtOH as compared to the effects of Tat or EtOH alone.	Ethanol	184-188	cAMP responsive element binding protein 1	Mus musculus	77-81
15589507-6	2005	In addition, DNA binding activities of nuclear factor-kappaB (NF-kappaB) and CREB in both brain regions and SP-1 in the hippocampus were more pronounced in mice injected with Tat plus EtOH as compared to the effects of Tat or EtOH alone.	Ethanol	226-230	cAMP responsive element binding protein 1	Mus musculus	77-81
15663480-1	2005	The transcription factor cAMP response element binding protein (CREB), a member of the basic region leucine zipper (bZIP) family of proteins, is the major cAMP response element (CRE) binding.	Cyclic AMP	25-29	cAMP responsive element binding protein 1	Mus musculus	64-68
15878804-6	2005	However, N-methyl-d-aspartate stimulation- and depolarization-induced phosphorylation of cAMP-response element-binding protein (CREB) was significantly attenuated in -/- hippocampal neurons, suggesting an impairment in an activity-dependent gene expression cascade.	N-Methylaspartate	9-29	cAMP responsive element binding protein 1	Mus musculus	89-126
15878804-6	2005	However, N-methyl-d-aspartate stimulation- and depolarization-induced phosphorylation of cAMP-response element-binding protein (CREB) was significantly attenuated in -/- hippocampal neurons, suggesting an impairment in an activity-dependent gene expression cascade.	N-Methylaspartate	9-29	cAMP responsive element binding protein 1	Mus musculus	128-132
15531295-0	2004	Piperine is a potent inhibitor of nuclear factor-kappaB (NF-kappaB), c-Fos, CREB, ATF-2 and proinflammatory cytokine gene expression in B16F-10 melanoma cells.	piperine	0-8	cAMP responsive element binding protein 1	Mus musculus	76-80
15893884-3	2005	Considering whether FosB and adrenergic signaling might share a signaling pathway important for maternal behavior, we examined the role of a potential intermediary, cyclic AMP response element-binding protein (CREB).	Cyclic AMP	165-175	cAMP responsive element binding protein 1	Mus musculus	210-214
15893884-9	2005	Interestingly, the number of cells immunostaining for phospho-CREB (on Ser(133)) in the medial preoptic area of the hypothalamus, a key region for the expression of maternal behavior, increased nearly three-fold in wild-type mice following exposure to pups but not to novel objects.	Serine	71-74	cAMP responsive element binding protein 1	Mus musculus	62-66
15531295-7	2004	We found that the nuclear translocation of p65, p50, c-Rel subunits of NF-kappaB and other transcription factors such as ATF-2, c-Fos and CREB were inhibited by the treatment of piperine.	piperine	178-186	cAMP responsive element binding protein 1	Mus musculus	138-142
15213229-10	2004	We demonstrated that the transcription factors from RINm5F nuclear extracts specifically bound to oligonucleotides containing C/EBP, AhR, or CREB consensus sites.	Oligonucleotides	98-114	cAMP responsive element binding protein 1	Mus musculus	141-145
15659802-0	2004	Cooperative effects between protein kinase A and p44/p42 mitogen-activated protein kinase to promote cAMP-responsive element binding protein activation after beta cell stimulation by glucose and its alteration due to glucotoxicity.	Glucose	183-190	cAMP responsive element binding protein 1	Mus musculus	101-140
15659802-4	2004	The observation that glucose-induced CREB phosphorylation was totally inhibited by the PKA inhibitor H89 (2 microM) and reduced by 50% with the ERK1/2 inhibitor PD98059 (20 microM) indicates that ERK1/2, located downstream of PKA, cooperates with PKA and is responsible for half of the PKA-mediated CREB phosphorylation elicited by glucose in MIN6 beta cells.	Glucose	21-28	cAMP responsive element binding protein 1	Mus musculus	37-41
15659802-4	2004	The observation that glucose-induced CREB phosphorylation was totally inhibited by the PKA inhibitor H89 (2 microM) and reduced by 50% with the ERK1/2 inhibitor PD98059 (20 microM) indicates that ERK1/2, located downstream of PKA, cooperates with PKA and is responsible for half of the PKA-mediated CREB phosphorylation elicited by glucose in MIN6 beta cells.	Glucose	21-28	cAMP responsive element binding protein 1	Mus musculus	299-303
15659802-4	2004	The observation that glucose-induced CREB phosphorylation was totally inhibited by the PKA inhibitor H89 (2 microM) and reduced by 50% with the ERK1/2 inhibitor PD98059 (20 microM) indicates that ERK1/2, located downstream of PKA, cooperates with PKA and is responsible for half of the PKA-mediated CREB phosphorylation elicited by glucose in MIN6 beta cells.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	101-104	cAMP responsive element binding protein 1	Mus musculus	37-41
15659802-4	2004	The observation that glucose-induced CREB phosphorylation was totally inhibited by the PKA inhibitor H89 (2 microM) and reduced by 50% with the ERK1/2 inhibitor PD98059 (20 microM) indicates that ERK1/2, located downstream of PKA, cooperates with PKA and is responsible for half of the PKA-mediated CREB phosphorylation elicited by glucose in MIN6 beta cells.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	161-168	cAMP responsive element binding protein 1	Mus musculus	37-41
15659802-4	2004	The observation that glucose-induced CREB phosphorylation was totally inhibited by the PKA inhibitor H89 (2 microM) and reduced by 50% with the ERK1/2 inhibitor PD98059 (20 microM) indicates that ERK1/2, located downstream of PKA, cooperates with PKA and is responsible for half of the PKA-mediated CREB phosphorylation elicited by glucose in MIN6 beta cells.	Glucose	332-339	cAMP responsive element binding protein 1	Mus musculus	37-41
15659802-5	2004	We also found that exposure of mu cells for 24 h to high glucose (25 mM) induced a 70% decrease in cellular ERK1/2 and a 50% decrease in CREB content.	Glucose	57-64	cAMP responsive element binding protein 1	Mus musculus	137-141
15659802-6	2004	In high-glucose-treated, ERK1/2- and CREB-downregulated beta cells, there was a loss of glucose (10 mM, 5 min)-stimulated ERK1/2 and CREB phosphorylation that was associated with nuclear apoptotic characteristics.	Glucose	8-15	cAMP responsive element binding protein 1	Mus musculus	37-41
15578094-6	2004	This protective effect is possibly due to stabilization of synaptic circuitry via alterations in gene expression by activation of the cAMP-dependent protein kinase (PKA)/cAMP regulatory element-binding protein (CREB) signaling pathway that make the synapses more resistant to the insult inflicted by Abeta.	Cyclic AMP	134-138	cAMP responsive element binding protein 1	Mus musculus	211-215
15578094-6	2004	This protective effect is possibly due to stabilization of synaptic circuitry via alterations in gene expression by activation of the cAMP-dependent protein kinase (PKA)/cAMP regulatory element-binding protein (CREB) signaling pathway that make the synapses more resistant to the insult inflicted by Abeta.	Cyclic AMP	170-174	cAMP responsive element binding protein 1	Mus musculus	211-215
15578094-7	2004	Thus, agents that enhance the cAMP/PKA/CREB pathway have potential for the treatment of AD and other diseases associated with elevated Abeta42 levels.	Cyclic AMP	30-34	cAMP responsive element binding protein 1	Mus musculus	39-43
15470720-3	2004	Because one of the main downstream effectors of the cAMP signaling pathway is cAMP-response element binding (CREB), we reasoned that it might affect the expression of genes associated with differentiation and apoptotic events in NBP2 cells.	Cyclic AMP	52-56	cAMP responsive element binding protein 1	Mus musculus	109-113
15470720-3	2004	Because one of the main downstream effectors of the cAMP signaling pathway is cAMP-response element binding (CREB), we reasoned that it might affect the expression of genes associated with differentiation and apoptotic events in NBP2 cells.	Cyclic AMP	78-82	cAMP responsive element binding protein 1	Mus musculus	109-113
15470720-7	2004	Our data suggest that increased levels of cAMP function through not only CREB but also other signaling pathways that account for the additional cAMP-induced effects, including irreversible differentiation and onset of apoptosis during partial inhibition of proteasome in NBP2 cells.	Cyclic AMP	42-46	cAMP responsive element binding protein 1	Mus musculus	73-77
15557818-4	2004	Both plasminogen and gangliosides activated PKA and increased the DNA binding activity of the cAMP response element- binding protein (CREB).	Gangliosides	21-33	cAMP responsive element binding protein 1	Mus musculus	94-132
15557818-4	2004	Both plasminogen and gangliosides activated PKA and increased the DNA binding activity of the cAMP response element- binding protein (CREB).	Gangliosides	21-33	cAMP responsive element binding protein 1	Mus musculus	134-138
15299023-1	2004	We have shown that the two types of cAMP-dependent protein kinase (PKA) in NG108-15 cells differentially mediate forskolin- and ethanol-induced cAMP response element (CRE)-binding protein (CREB) phosphorylation and CRE-mediated gene transcription.	Cyclic AMP	36-40	cAMP responsive element binding protein 1	Mus musculus	189-193
15299023-1	2004	We have shown that the two types of cAMP-dependent protein kinase (PKA) in NG108-15 cells differentially mediate forskolin- and ethanol-induced cAMP response element (CRE)-binding protein (CREB) phosphorylation and CRE-mediated gene transcription.	Colforsin	113-122	cAMP responsive element binding protein 1	Mus musculus	189-193
15299023-1	2004	We have shown that the two types of cAMP-dependent protein kinase (PKA) in NG108-15 cells differentially mediate forskolin- and ethanol-induced cAMP response element (CRE)-binding protein (CREB) phosphorylation and CRE-mediated gene transcription.	Ethanol	128-135	cAMP responsive element binding protein 1	Mus musculus	189-193
15299023-1	2004	We have shown that the two types of cAMP-dependent protein kinase (PKA) in NG108-15 cells differentially mediate forskolin- and ethanol-induced cAMP response element (CRE)-binding protein (CREB) phosphorylation and CRE-mediated gene transcription.	Cyclic AMP	144-148	cAMP responsive element binding protein 1	Mus musculus	189-193
15240013-0	2004	Synergistic activation of CREB-mediated transcription by forskolin and phorbol ester requires PKC and depends on the glutamine-rich Q2 transactivation domain.	Colforsin	57-66	cAMP responsive element binding protein 1	Mus musculus	26-30
15240013-0	2004	Synergistic activation of CREB-mediated transcription by forskolin and phorbol ester requires PKC and depends on the glutamine-rich Q2 transactivation domain.	Phorbol Esters	71-84	cAMP responsive element binding protein 1	Mus musculus	26-30
15240013-0	2004	Synergistic activation of CREB-mediated transcription by forskolin and phorbol ester requires PKC and depends on the glutamine-rich Q2 transactivation domain.	Glutamine	117-126	cAMP responsive element binding protein 1	Mus musculus	26-30
15240013-1	2004	Recruitment of a RNA polymerase II complex by the glutamine-rich Q2 domain of cAMP response element-binding protein (CREB) allows basal transcriptional activity, while recruitment of CBP/p300 through signal-induced phosphorylation of the kinase-inducible domain at serine-133 enhances CREB-dependent transcription.	Serine	265-271	cAMP responsive element binding protein 1	Mus musculus	78-115
15240013-1	2004	Recruitment of a RNA polymerase II complex by the glutamine-rich Q2 domain of cAMP response element-binding protein (CREB) allows basal transcriptional activity, while recruitment of CBP/p300 through signal-induced phosphorylation of the kinase-inducible domain at serine-133 enhances CREB-dependent transcription.	Serine	265-271	cAMP responsive element binding protein 1	Mus musculus	117-121
15312676-1	2004	The expression of the transcriptional regulators activating transcription factor-1 (ATF-1) and cAMP-responsive element (CRE)-binding protein (CREB) is upregulated in metastatic melanoma cells.	Cyclic AMP	95-99	cAMP responsive element binding protein 1	Mus musculus	142-146
15659802-6	2004	In high-glucose-treated, ERK1/2- and CREB-downregulated beta cells, there was a loss of glucose (10 mM, 5 min)-stimulated ERK1/2 and CREB phosphorylation that was associated with nuclear apoptotic characteristics.	Glucose	8-15	cAMP responsive element binding protein 1	Mus musculus	133-137
15659802-6	2004	In high-glucose-treated, ERK1/2- and CREB-downregulated beta cells, there was a loss of glucose (10 mM, 5 min)-stimulated ERK1/2 and CREB phosphorylation that was associated with nuclear apoptotic characteristics.	Glucose	88-95	cAMP responsive element binding protein 1	Mus musculus	37-41
15659802-6	2004	In high-glucose-treated, ERK1/2- and CREB-downregulated beta cells, there was a loss of glucose (10 mM, 5 min)-stimulated ERK1/2 and CREB phosphorylation that was associated with nuclear apoptotic characteristics.	Glucose	88-95	cAMP responsive element binding protein 1	Mus musculus	133-137
15451364-0	2004	Colocalization of phosphorylated CREB with calcium/calmodulin-dependent protein kinase IV in hippocampal neurons induced by ohmfentanyl stereoisomers.	ohmfentanyl	124-135	cAMP responsive element binding protein 1	Mus musculus	33-37
15451364-1	2004	The transcription factor cAMP response element-binding protein (CREB) plays an important role in opioids dependence.	Cyclic AMP	25-29	cAMP responsive element binding protein 1	Mus musculus	64-68
15451364-4	2004	The results showed that F9202, F9204 or morphine, which could induce CPP, enhanced CREB phosphorylation and the expression of CaMKIV in hippocampus from CPP mice without affecting total CREB protein level.	Morphine	40-48	cAMP responsive element binding protein 1	Mus musculus	83-87
15451364-4	2004	The results showed that F9202, F9204 or morphine, which could induce CPP, enhanced CREB phosphorylation and the expression of CaMKIV in hippocampus from CPP mice without affecting total CREB protein level.	Morphine	40-48	cAMP responsive element binding protein 1	Mus musculus	186-190
15451364-5	2004	The CREB phosphorylation of cultured hippocampal neurons was also enhanced and reached its peak level at 30 min upon exposure to F9202 (100 nM), F9204 (100 nM) or morphine (1 microM), while the total CREB protein level was not altered.	Morphine	163-171	cAMP responsive element binding protein 1	Mus musculus	4-8
15451364-5	2004	The CREB phosphorylation of cultured hippocampal neurons was also enhanced and reached its peak level at 30 min upon exposure to F9202 (100 nM), F9204 (100 nM) or morphine (1 microM), while the total CREB protein level was not altered.	Morphine	163-171	cAMP responsive element binding protein 1	Mus musculus	200-204
15451364-6	2004	KN-62 (10 microM), an inhibitor of CaM kinases, prevented CREB phosphorylation induced by morphine, F9202, and F9204 without change of total CREB level.	KN 62	0-5	cAMP responsive element binding protein 1	Mus musculus	58-62
15451364-6	2004	KN-62 (10 microM), an inhibitor of CaM kinases, prevented CREB phosphorylation induced by morphine, F9202, and F9204 without change of total CREB level.	Morphine	90-98	cAMP responsive element binding protein 1	Mus musculus	58-62
15163620-13	2004	Thus CREB-1, binding to one or more CRE-like elements in the -86/-60 region, trans-activates the HKalpha(2) gene and may represent an important link between rapid and delayed effects of cAMP on HKalpha(2) activity.	Cyclic AMP	186-190	cAMP responsive element binding protein 1	Mus musculus	5-11
15542701-5	2004	In wild-type mice pretreated with PCP, the levels of cAMP, cAMP response element binding protein (CREB), and c-fos mRNA in the nucleus accumbens were increased.	Phencyclidine	34-37	cAMP responsive element binding protein 1	Mus musculus	59-96
15542701-5	2004	In wild-type mice pretreated with PCP, the levels of cAMP, cAMP response element binding protein (CREB), and c-fos mRNA in the nucleus accumbens were increased.	Phencyclidine	34-37	cAMP responsive element binding protein 1	Mus musculus	98-102
15213229-11	2004	Forskolin, an activator of adenyl cyclase, increased COX-2 promoter activity via the CREB site.	Colforsin	0-9	cAMP responsive element binding protein 1	Mus musculus	85-89
15138267-1	2004	The cAMP-response element-binding protein (CREB) is activated by phosphorylation on Ser-133 and plays a key role in the proliferative and survival responses of mature B cells to B cell receptor (BCR) signaling.	Serine	84-87	cAMP responsive element binding protein 1	Mus musculus	4-41
15258586-5	2004	These features are associated with a decrease in adenosine tone, as measured indirectly as a reduction in A(1) receptor-mediated inhibition of glutamate excitatory postsynaptic currents (EPSCs) in the nucleus accumbens, leading to increased phosphorylation of CRE-binding protein (CREB) in the striatum.	Adenosine	49-58	cAMP responsive element binding protein 1	Mus musculus	260-279
15258586-5	2004	These features are associated with a decrease in adenosine tone, as measured indirectly as a reduction in A(1) receptor-mediated inhibition of glutamate excitatory postsynaptic currents (EPSCs) in the nucleus accumbens, leading to increased phosphorylation of CRE-binding protein (CREB) in the striatum.	Adenosine	49-58	cAMP responsive element binding protein 1	Mus musculus	281-285
15258586-5	2004	These features are associated with a decrease in adenosine tone, as measured indirectly as a reduction in A(1) receptor-mediated inhibition of glutamate excitatory postsynaptic currents (EPSCs) in the nucleus accumbens, leading to increased phosphorylation of CRE-binding protein (CREB) in the striatum.	Glutamic Acid	143-152	cAMP responsive element binding protein 1	Mus musculus	260-279
15258586-5	2004	These features are associated with a decrease in adenosine tone, as measured indirectly as a reduction in A(1) receptor-mediated inhibition of glutamate excitatory postsynaptic currents (EPSCs) in the nucleus accumbens, leading to increased phosphorylation of CRE-binding protein (CREB) in the striatum.	Glutamic Acid	143-152	cAMP responsive element binding protein 1	Mus musculus	281-285
15282271-7	2004	The CREB(alphaDelta) mutant mice show deficits in FS-induced reinstatement of conditioned place preference.	phenylalanylserine	50-52	cAMP responsive element binding protein 1	Mus musculus	4-8
15138267-3	2004	We found the novel PKCdelta (nPKCdelta) activator bistratene A is sufficient to induce CREB phosphorylation in murine splenic B cells.	bistratene	50-60	cAMP responsive element binding protein 1	Mus musculus	87-91
15138267-4	2004	The pharmacological inhibitor Go6976, which targets conventional PKCs and PKCmu, has no effect on CREB phosphorylation, whereas the nPKCdelta inhibitor rottlerin blocks CREB phosphorylation following BCR cross-linking.	rottlerin	152-161	cAMP responsive element binding protein 1	Mus musculus	169-173
15138267-1	2004	The cAMP-response element-binding protein (CREB) is activated by phosphorylation on Ser-133 and plays a key role in the proliferative and survival responses of mature B cells to B cell receptor (BCR) signaling.	Serine	84-87	cAMP responsive element binding protein 1	Mus musculus	43-47
15138267-5	2004	Bryostatin 1 selectively prevents nPKCdelta depletion by phorbol 12-myristate 13-acetate when coapplied, coincident with protection of BCR-induced CREB phosphorylation.	bryostatin 1	0-12	cAMP responsive element binding protein 1	Mus musculus	147-151
15138267-2	2004	The signal link between the BCR and CREB activation depends on a phorbol ester (phorbol 12-myristate 13-acetate)-sensitive protein kinase C (PKC) activity and not protein kinase A or calmodulin kinase; however, the identity and role of the PKC(s) activity has not been elucidated.	Phorbol Esters	65-78	cAMP responsive element binding protein 1	Mus musculus	36-40
15138267-9	2004	We also found that p90 RSK directly phosphorylates CREB on Ser-133 following BCR cross-linking and is positioned downstream of nPKCdelta.	Serine	59-62	cAMP responsive element binding protein 1	Mus musculus	51-55
15138267-2	2004	The signal link between the BCR and CREB activation depends on a phorbol ester (phorbol 12-myristate 13-acetate)-sensitive protein kinase C (PKC) activity and not protein kinase A or calmodulin kinase; however, the identity and role of the PKC(s) activity has not been elucidated.	Tetradecanoylphorbol Acetate	80-111	cAMP responsive element binding protein 1	Mus musculus	36-40
15240803-5	2004	Our data further show that subunit gene expression in hippocampal neurons is mediated by the cAMP response element-binding protein (CREB) by binding to unique cAMP response elements in the alternative promoter regions.	Cyclic AMP	93-97	cAMP responsive element binding protein 1	Mus musculus	132-136
15176089-5	2004	We generated two independent strains of nestin-tTA transgenic animals and crossed founder mice from both lines to mice containing a tetracycline-regulated transgene (mCREB) whose expression served as a marker for the activity of the nestin-tTA transgene.	Tetracycline	132-144	cAMP responsive element binding protein 1	Mus musculus	166-171
15240803-8	2004	In addition, the CREB-related factor activating transcription factor-4 (ATF4) has been shown to interact directly with GABA(B)R1 in neurons, and we show that ATF4 differentially regulates GABA(B)R1a and GABA(B)R1b promoter activity.	gamma-Aminobutyric Acid	119-123	cAMP responsive element binding protein 1	Mus musculus	17-21
15240803-8	2004	In addition, the CREB-related factor activating transcription factor-4 (ATF4) has been shown to interact directly with GABA(B)R1 in neurons, and we show that ATF4 differentially regulates GABA(B)R1a and GABA(B)R1b promoter activity.	gamma-Aminobutyric Acid	188-192	cAMP responsive element binding protein 1	Mus musculus	17-21
15207912-7	2004	Additionally, forskolin-induced transcription was inhibited by a dominant-negative mutant of CRE-binding protein (CREB) in CATH.a cells.	Colforsin	14-23	cAMP responsive element binding protein 1	Mus musculus	93-112
15207912-7	2004	Additionally, forskolin-induced transcription was inhibited by a dominant-negative mutant of CRE-binding protein (CREB) in CATH.a cells.	Colforsin	14-23	cAMP responsive element binding protein 1	Mus musculus	114-118
15207912-9	2004	This study provides evidence that the CRE site in the CART proximal promoter is involved in cAMP/PKA/CREB regulation in cells having a neuronal phenotype.	Cyclic AMP	92-96	cAMP responsive element binding protein 1	Mus musculus	101-105
14976146-4	2004	Estrogen significantly (P &lt; 0.05) increased the numbers of phospho-cAMP response element binding protein (phospho-CREB)-immunoreactive cells in specific brain regions of wild-type mice in a time-dependent manner beginning within 15 min.	Cyclic AMP	70-74	cAMP responsive element binding protein 1	Mus musculus	117-121
15146178-4	2004	Here, we show in vitro and in "knock-in" mice that a mutant CBP (S436A) is aberrantly recruited to CREB protein, resulting in inappropriate activation of gluconeogenesis in the fed state and glucose intolerance resulting from increased hepatic glucose production.	Glucose	191-198	cAMP responsive element binding protein 1	Mus musculus	99-103
15212707-0	2004	IFN-gamma activates cAMP/PKA/CREB signaling pathway in murine peritoneal macrophages.	Cyclic AMP	20-24	cAMP responsive element binding protein 1	Mus musculus	29-33
15212707-2	2004	The present study establishes for the first time that cyclic adenosine monophosphate, protein kinase A, and cAMP response element-binding protein (cAMP/PKA/CREB) are coregulators of the IFN-gamma signaling pathway.	Cyclic AMP	54-84	cAMP responsive element binding protein 1	Mus musculus	156-160
15212707-2	2004	The present study establishes for the first time that cyclic adenosine monophosphate, protein kinase A, and cAMP response element-binding protein (cAMP/PKA/CREB) are coregulators of the IFN-gamma signaling pathway.	Cyclic AMP	108-112	cAMP responsive element binding protein 1	Mus musculus	156-160
15212707-2	2004	The present study establishes for the first time that cyclic adenosine monophosphate, protein kinase A, and cAMP response element-binding protein (cAMP/PKA/CREB) are coregulators of the IFN-gamma signaling pathway.	Cyclic AMP	147-151	cAMP responsive element binding protein 1	Mus musculus	156-160
15212707-5	2004	It appears that a novel cAMP/PKA/CREB signaling pathway is activated by IFN-gamma in macrophages, suggesting that an alternate signaling pathway exists in macrophages in response to IFN-gamma.	Cyclic AMP	24-28	cAMP responsive element binding protein 1	Mus musculus	33-37
15146178-4	2004	Here, we show in vitro and in "knock-in" mice that a mutant CBP (S436A) is aberrantly recruited to CREB protein, resulting in inappropriate activation of gluconeogenesis in the fed state and glucose intolerance resulting from increased hepatic glucose production.	Glucose	244-251	cAMP responsive element binding protein 1	Mus musculus	99-103
15163695-0	2004	Partial deletion of the cAMP response element-binding protein gene promotes alcohol-drinking behaviors.	Alcohols	76-83	cAMP responsive element binding protein 1	Mus musculus	24-61
15029152-0	2004	Modulation of anxiety-like behavior and morphine dependence in CREB-deficient mice.	Morphine	40-48	cAMP responsive element binding protein 1	Mus musculus	63-67
15163695-1	2004	The cAMP response element-binding protein (CREB) gene transcription factor has been shown to play a role in the synaptic plasticity associated with drug addictive behaviors; however, the causal role of the CREB gene in alcohol-drinking behaviors is unknown.	Alcohols	219-226	cAMP responsive element binding protein 1	Mus musculus	4-41
15163695-1	2004	The cAMP response element-binding protein (CREB) gene transcription factor has been shown to play a role in the synaptic plasticity associated with drug addictive behaviors; however, the causal role of the CREB gene in alcohol-drinking behaviors is unknown.	Alcohols	219-226	cAMP responsive element binding protein 1	Mus musculus	43-47
15163695-1	2004	The cAMP response element-binding protein (CREB) gene transcription factor has been shown to play a role in the synaptic plasticity associated with drug addictive behaviors; however, the causal role of the CREB gene in alcohol-drinking behaviors is unknown.	Alcohols	219-226	cAMP responsive element binding protein 1	Mus musculus	206-210
15163695-3	2004	It was found that CREB-haplodeficient (+/-) mice have higher preference for ethanol but not for sucrose solution than wild-type (+/+) littermates.	Ethanol	76-83	cAMP responsive element binding protein 1	Mus musculus	18-22
15163695-4	2004	The functional aspects of the CREB gene transcription factor were also investigated by measuring the protein levels of phosphorylated CREB (p-CREB) and the expression of cAMP-inducible genes such as neuropeptide Y (NPY) and brain-derived neurotrophic factor (BDNF).	Cyclic AMP	170-174	cAMP responsive element binding protein 1	Mus musculus	30-34
15163695-6	2004	It was also found that CREB-deficient (+/-) mice displayed more anxiety-like behaviors and that acute ethanol exposure produced anxiolytic effects and significantly increased protein levels of p-CREB and NPY in the central and medial but not in the basolateral amygdala of wild-type mice, but these effects are attenuated in CREB-deficient mice compared with wild-type mice.	Ethanol	102-109	cAMP responsive element binding protein 1	Mus musculus	23-27
15163695-7	2004	These results provide the first direct evidence that a haplodeficiency of the CREB gene is associated with increased alcohol-drinking behaviors.	Alcohols	117-124	cAMP responsive element binding protein 1	Mus musculus	78-82
15163695-8	2004	Furthermore, alcohol drinking and anxiety-like behaviors in CREB-haplodeficient mice may possibly be related to decreased expression of NPY and BDNF in the brains of these mice.	Alcohols	13-20	cAMP responsive element binding protein 1	Mus musculus	60-64
15135217-4	2004	Electrophoretic mobility shift assays revealed that the beta(2)AR agonist clenbuterol (CLE) or high levels of cAMP elicited a time-dependent increase in C/EBPdelta binding activity as well as phosphorylated CREB (P-CREB).	Clenbuterol	74-85	cAMP responsive element binding protein 1	Mus musculus	207-211
15135217-5	2004	When DEX, which per se showed little effect on these transcription factors, was combined with CLE, dibutyryl cAMP or isoproterenol, enhanced induction of P-CREB and C/EBP binding activity as well as NGF mRNA was observed.	Dexamethasone	5-8	cAMP responsive element binding protein 1	Mus musculus	156-160
15135217-4	2004	Electrophoretic mobility shift assays revealed that the beta(2)AR agonist clenbuterol (CLE) or high levels of cAMP elicited a time-dependent increase in C/EBPdelta binding activity as well as phosphorylated CREB (P-CREB).	Clenbuterol	74-85	cAMP responsive element binding protein 1	Mus musculus	215-219
15135217-5	2004	When DEX, which per se showed little effect on these transcription factors, was combined with CLE, dibutyryl cAMP or isoproterenol, enhanced induction of P-CREB and C/EBP binding activity as well as NGF mRNA was observed.	Bucladesine	99-113	cAMP responsive element binding protein 1	Mus musculus	156-160
15135217-4	2004	Electrophoretic mobility shift assays revealed that the beta(2)AR agonist clenbuterol (CLE) or high levels of cAMP elicited a time-dependent increase in C/EBPdelta binding activity as well as phosphorylated CREB (P-CREB).	Clenbuterol	87-90	cAMP responsive element binding protein 1	Mus musculus	207-211
15135217-5	2004	When DEX, which per se showed little effect on these transcription factors, was combined with CLE, dibutyryl cAMP or isoproterenol, enhanced induction of P-CREB and C/EBP binding activity as well as NGF mRNA was observed.	Isoproterenol	117-130	cAMP responsive element binding protein 1	Mus musculus	156-160
15135217-4	2004	Electrophoretic mobility shift assays revealed that the beta(2)AR agonist clenbuterol (CLE) or high levels of cAMP elicited a time-dependent increase in C/EBPdelta binding activity as well as phosphorylated CREB (P-CREB).	Clenbuterol	87-90	cAMP responsive element binding protein 1	Mus musculus	215-219
15135217-4	2004	Electrophoretic mobility shift assays revealed that the beta(2)AR agonist clenbuterol (CLE) or high levels of cAMP elicited a time-dependent increase in C/EBPdelta binding activity as well as phosphorylated CREB (P-CREB).	Cyclic AMP	110-114	cAMP responsive element binding protein 1	Mus musculus	207-211
15135217-4	2004	Electrophoretic mobility shift assays revealed that the beta(2)AR agonist clenbuterol (CLE) or high levels of cAMP elicited a time-dependent increase in C/EBPdelta binding activity as well as phosphorylated CREB (P-CREB).	Cyclic AMP	110-114	cAMP responsive element binding protein 1	Mus musculus	215-219
14988413-0	2004	Glucagon promotes cAMP-response element-binding protein phosphorylation via activation of ERK1/2 in MIN6 cell line and isolated islets of Langerhans.	Glucagon	0-8	cAMP responsive element binding protein 1	Mus musculus	18-55
14988413-9	2004	Our results uncover a novel mechanism by which the PKA/ERK1/2 signaling network engaged by glucagon, in situation of low glucose concentration, regulates phosphorylation of CREB, a transcription factor crucial for normal beta cell function and survival.	Glucagon	91-99	cAMP responsive element binding protein 1	Mus musculus	173-177
14988413-9	2004	Our results uncover a novel mechanism by which the PKA/ERK1/2 signaling network engaged by glucagon, in situation of low glucose concentration, regulates phosphorylation of CREB, a transcription factor crucial for normal beta cell function and survival.	Glucose	121-128	cAMP responsive element binding protein 1	Mus musculus	173-177
15080890-2	2004	In FVB/N nontransgenic mice, we observed that Purkinje cells showed low basal levels of Ser(133)-phosphorylated CREB protein yet displayed strong CRE-directed transcription.	Serine	88-91	cAMP responsive element binding protein 1	Mus musculus	112-116
14684744-7	2004	The protein kinase A (PKA) inhibitor H89 completely blocks the TCDD-dependent effect on C/EBPbeta promoter activity, indicating that TCDD activates CREB binding via a cAMP/PKA pathway, which is supported by the increased cAMP level and PKA activity observed after TCDD treatment.	Polychlorinated Dibenzodioxins	63-67	cAMP responsive element binding protein 1	Mus musculus	148-152
14684744-7	2004	The protein kinase A (PKA) inhibitor H89 completely blocks the TCDD-dependent effect on C/EBPbeta promoter activity, indicating that TCDD activates CREB binding via a cAMP/PKA pathway, which is supported by the increased cAMP level and PKA activity observed after TCDD treatment.	Polychlorinated Dibenzodioxins	133-137	cAMP responsive element binding protein 1	Mus musculus	148-152
14684744-7	2004	The protein kinase A (PKA) inhibitor H89 completely blocks the TCDD-dependent effect on C/EBPbeta promoter activity, indicating that TCDD activates CREB binding via a cAMP/PKA pathway, which is supported by the increased cAMP level and PKA activity observed after TCDD treatment.	Polychlorinated Dibenzodioxins	133-137	cAMP responsive element binding protein 1	Mus musculus	148-152
14684744-8	2004	Gel shift analyses demonstrated that CREB itself binds to the putative CREB motif that mediates the TCDD-dependent effect on C/EBPbeta gene transcription.	Polychlorinated Dibenzodioxins	100-104	cAMP responsive element binding protein 1	Mus musculus	37-41
14684744-8	2004	Gel shift analyses demonstrated that CREB itself binds to the putative CREB motif that mediates the TCDD-dependent effect on C/EBPbeta gene transcription.	Polychlorinated Dibenzodioxins	100-104	cAMP responsive element binding protein 1	Mus musculus	71-75
14684744-9	2004	Cotransfection experiments with CREB and PKA expression plasmids further supported our conclusions that the TCDD-dependent effect on C/EBPbeta transcription is mediated via PKA-dependent CREB activation.	Polychlorinated Dibenzodioxins	108-112	cAMP responsive element binding protein 1	Mus musculus	32-36
14684744-9	2004	Cotransfection experiments with CREB and PKA expression plasmids further supported our conclusions that the TCDD-dependent effect on C/EBPbeta transcription is mediated via PKA-dependent CREB activation.	Polychlorinated Dibenzodioxins	108-112	cAMP responsive element binding protein 1	Mus musculus	187-191
14687664-2	2004	Herein, we show that cadmium induces reactive oxygen species (ROS) that activate c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) and their substrates, activating transcription factor 2 (ATF-2), CRE-binding protein (CREB) and c-Jun.	Cadmium	21-28	cAMP responsive element binding protein 1	Mus musculus	224-243
14687664-2	2004	Herein, we show that cadmium induces reactive oxygen species (ROS) that activate c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) and their substrates, activating transcription factor 2 (ATF-2), CRE-binding protein (CREB) and c-Jun.	Cadmium	21-28	cAMP responsive element binding protein 1	Mus musculus	245-249
14687664-2	2004	Herein, we show that cadmium induces reactive oxygen species (ROS) that activate c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) and their substrates, activating transcription factor 2 (ATF-2), CRE-binding protein (CREB) and c-Jun.	Reactive Oxygen Species	37-60	cAMP responsive element binding protein 1	Mus musculus	224-243
14687664-2	2004	Herein, we show that cadmium induces reactive oxygen species (ROS) that activate c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) and their substrates, activating transcription factor 2 (ATF-2), CRE-binding protein (CREB) and c-Jun.	Reactive Oxygen Species	37-60	cAMP responsive element binding protein 1	Mus musculus	245-249
14687664-2	2004	Herein, we show that cadmium induces reactive oxygen species (ROS) that activate c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) and their substrates, activating transcription factor 2 (ATF-2), CRE-binding protein (CREB) and c-Jun.	Reactive Oxygen Species	62-65	cAMP responsive element binding protein 1	Mus musculus	224-243
14687664-2	2004	Herein, we show that cadmium induces reactive oxygen species (ROS) that activate c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) and their substrates, activating transcription factor 2 (ATF-2), CRE-binding protein (CREB) and c-Jun.	Reactive Oxygen Species	62-65	cAMP responsive element binding protein 1	Mus musculus	245-249
14985434-1	2004	The promoter for the kv3.1 potassium channel gene is regulated by a Ca2+-cAMP responsive element, which binds the transcription factor cAMP response element-binding protein (CREB).	Cyclic AMP	73-77	cAMP responsive element binding protein 1	Mus musculus	135-172
14985434-1	2004	The promoter for the kv3.1 potassium channel gene is regulated by a Ca2+-cAMP responsive element, which binds the transcription factor cAMP response element-binding protein (CREB).	Cyclic AMP	73-77	cAMP responsive element binding protein 1	Mus musculus	174-178
14743453-1	2004	Cyclic AMP response element binding protein (CREB) is a transcription factor expressed constitutively primarily in neurons and is activated by phosphorylation at Ser(133) residue.	Serine	162-165	cAMP responsive element binding protein 1	Mus musculus	0-43
14743453-1	2004	Cyclic AMP response element binding protein (CREB) is a transcription factor expressed constitutively primarily in neurons and is activated by phosphorylation at Ser(133) residue.	Serine	162-165	cAMP responsive element binding protein 1	Mus musculus	45-49
14764597-9	2004	These studies also showed a TZD-mediated inhibition of total and phospho-CREB(Ser133) levels, CREB promoter activity, and cAMP-response element-mediated transcription in PPARgamma hepatocytes.	tzd	28-31	cAMP responsive element binding protein 1	Mus musculus	73-77
14764597-9	2004	These studies also showed a TZD-mediated inhibition of total and phospho-CREB(Ser133) levels, CREB promoter activity, and cAMP-response element-mediated transcription in PPARgamma hepatocytes.	tzd	28-31	cAMP responsive element binding protein 1	Mus musculus	94-98
14764597-10	2004	Pretreatment of PPARgamma hepatocytes with okadaic acid, however, maintained higher total and phospho-CREB(Ser133) levels in the presence of TZD.	Okadaic Acid	43-55	cAMP responsive element binding protein 1	Mus musculus	102-106
15039316-7	2004	Cyclic AMP-dependent PKA activity was higher in macrophages infected with wild-type salmonellae compared to the spiC mutant, and Ser(132) phosphorylation of cyclic AMP response element-binding protein (CREB), which is an important mediator of PKA activation, correlated with the levels of PKA activity.	Cyclic AMP	0-10	cAMP responsive element binding protein 1	Mus musculus	157-200
15039316-7	2004	Cyclic AMP-dependent PKA activity was higher in macrophages infected with wild-type salmonellae compared to the spiC mutant, and Ser(132) phosphorylation of cyclic AMP response element-binding protein (CREB), which is an important mediator of PKA activation, correlated with the levels of PKA activity.	Cyclic AMP	0-10	cAMP responsive element binding protein 1	Mus musculus	202-206
15039316-7	2004	Cyclic AMP-dependent PKA activity was higher in macrophages infected with wild-type salmonellae compared to the spiC mutant, and Ser(132) phosphorylation of cyclic AMP response element-binding protein (CREB), which is an important mediator of PKA activation, correlated with the levels of PKA activity.	Serine	129-132	cAMP responsive element binding protein 1	Mus musculus	157-200
15039316-7	2004	Cyclic AMP-dependent PKA activity was higher in macrophages infected with wild-type salmonellae compared to the spiC mutant, and Ser(132) phosphorylation of cyclic AMP response element-binding protein (CREB), which is an important mediator of PKA activation, correlated with the levels of PKA activity.	Serine	129-132	cAMP responsive element binding protein 1	Mus musculus	202-206
14975676-10	2004	In contrast, chronic morphine treatment in mu-KO mice, but not in delta- or kappa-KO, resulted in a paradoxical upregulation of Galphai1/2 (12-19%), PKA (19-21%,) and phosphorylated CREB (21-73%), but not total CREB, in cortex and/or striatum.	Morphine	21-29	cAMP responsive element binding protein 1	Mus musculus	182-186
14975676-10	2004	In contrast, chronic morphine treatment in mu-KO mice, but not in delta- or kappa-KO, resulted in a paradoxical upregulation of Galphai1/2 (12-19%), PKA (19-21%,) and phosphorylated CREB (21-73%), but not total CREB, in cortex and/or striatum.	Morphine	21-29	cAMP responsive element binding protein 1	Mus musculus	211-215
14988413-7	2004	Miniglucagon, produced from glucagon and released together with the mother hormone from the alpha cells in low glucose situations, blocks the insulinotropic effect of glucagon, whereas it does not inhibit the glucagon-induced PKA/ERK1/2/CREB pathway.	Glucagon	4-12	cAMP responsive element binding protein 1	Mus musculus	237-241
14651966-7	2003	Furthermore, plasminogen stimulated CREB and NF-kappaB DNA binding activity, and this activation was also reduced by trolox and NAC.	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	117-123	cAMP responsive element binding protein 1	Mus musculus	36-40
15106839-2	2004	Nurr1 expression was induced by forskolin, an adenylate cyclase activator, via activation of CREB in both N2A and C6 cells.	Colforsin	32-41	cAMP responsive element binding protein 1	Mus musculus	93-97
14724230-1	2004	Previous studies have demonstrated that activation of the cAMP cascade, including the cAMP response element-binding protein (CREB), increases the proliferation and survival of newborn neurons in adult mouse hippocampus.	Cyclic AMP	58-62	cAMP responsive element binding protein 1	Mus musculus	86-123
14724230-1	2004	Previous studies have demonstrated that activation of the cAMP cascade, including the cAMP response element-binding protein (CREB), increases the proliferation and survival of newborn neurons in adult mouse hippocampus.	Cyclic AMP	58-62	cAMP responsive element binding protein 1	Mus musculus	125-129
14724230-2	2004	In the present study, we determined whether the cAMP-CREB cascade also influences the morphological maturation of newborn neurons in the subgranular zone of the hippocampus.	Cyclic AMP	48-52	cAMP responsive element binding protein 1	Mus musculus	53-57
14724230-8	2004	These findings indicate that the cAMP-CREB cascade plays an important role in the differentiation and maturation of newborn neurons in hippocampus.	Cyclic AMP	33-37	cAMP responsive element binding protein 1	Mus musculus	38-42
14680822-4	2003	In the present report, we show that the -92 to -40bp region is essential for the transcription of brca2 in murine mammary cells and that this nucleotide sequence contains one putative CREB/ATF consensus site (cAMP responsive element: CRE).	Cyclic AMP	209-213	cAMP responsive element binding protein 1	Mus musculus	184-188
14614508-2	2003	In response to pancreatic glucagon and adrenal cortisol, the cAMP-responsive transcription factor CREB activates gluconeogenic and fatty acid oxidation programmes by stimulating expression of the nuclear hormone receptor coactivator PGC-1 (refs 2-5).	Cyclic AMP	61-65	cAMP responsive element binding protein 1	Mus musculus	98-102
14648587-7	2003	On the other hand, inhibition of a mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway by a MAPK/ERK kinase (MEK) inhibitor (PD98059) suppressed both neuritogenesis and neurite outgrowth without CREB phosphorylation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	165-172	cAMP responsive element binding protein 1	Mus musculus	235-239
14622103-0	2003	Differential distribution of CREB in the mesolimbic dopamine reward pathway.	Dopamine	52-60	cAMP responsive element binding protein 1	Mus musculus	29-33
14622103-6	2003	Phospho-CREB levels are increased in the NAc of both wild-type and CREBalphaDelta mutant animals after cocaine.	Cocaine	103-110	cAMP responsive element binding protein 1	Mus musculus	8-12
14622103-7	2003	However, morphine-induced increases of phospho-CREB levels are seen in the VTA of wild-type mice but not CREBalphaDelta mutant mice.	Morphine	9-17	cAMP responsive element binding protein 1	Mus musculus	47-51
14614508-2	2003	In response to pancreatic glucagon and adrenal cortisol, the cAMP-responsive transcription factor CREB activates gluconeogenic and fatty acid oxidation programmes by stimulating expression of the nuclear hormone receptor coactivator PGC-1 (refs 2-5).	Fatty Acids	131-141	cAMP responsive element binding protein 1	Mus musculus	98-102
12958156-6	2003	We showed that its expression is dependent on CREB and p53 and is sensitive to calcium and tumor necrosis factor alpha.	Calcium	79-86	cAMP responsive element binding protein 1	Mus musculus	46-50
14531803-8	2003	Serum and angiotensin II (Ang II)-stimulated activities of p38 or ERK1/2 MAPKs, and cyclic adenosine monophosphate (cAMP)-responsive element binding protein (CREB) transcription factor were lower in 12/15-LO knockout relative to wild-type cells.	Cyclic AMP	116-120	cAMP responsive element binding protein 1	Mus musculus	158-162
12725729-9	2003	Additionally, we show that light induction of cfos and light-dependent phosphorylation of CREB at serine 133 are not affected in these animals.	Serine	98-104	cAMP responsive element binding protein 1	Mus musculus	90-94
14531803-8	2003	Serum and angiotensin II (Ang II)-stimulated activities of p38 or ERK1/2 MAPKs, and cyclic adenosine monophosphate (cAMP)-responsive element binding protein (CREB) transcription factor were lower in 12/15-LO knockout relative to wild-type cells.	Cyclic AMP	84-114	cAMP responsive element binding protein 1	Mus musculus	158-162
14566342-5	2003	Gene expression induced by short-term DeltaFosB and by CREB was strikingly similar, and both reduced the rewarding effects of cocaine, whereas prolonged DeltaFosB expression increased drug reward.	Cocaine	126-133	cAMP responsive element binding protein 1	Mus musculus	55-59
12930888-3	2003	A critical role for cAMP signaling during CREB-dependent long-term memory formation appears to be evolutionarily conserved.	Cyclic AMP	20-24	cAMP responsive element binding protein 1	Mus musculus	42-46
12930888-4	2003	From this observation, we reasoned that drugs that modulate CREB function by enhancing cAMP signaling might yield an effective treatment for the memory defect(s) of CBP+/- mice.	Cyclic AMP	87-91	cAMP responsive element binding protein 1	Mus musculus	60-64
12859982-5	2003	In Y-1 cells, which lack AhR, cAMP induction is totally dependent on the FUER, including absolute requirements for upstream and downstream halves of this region, and for CREB activity at a CRE sequence located at the 3(")-end.	Cyclic AMP	30-34	cAMP responsive element binding protein 1	Mus musculus	170-174
12887679-2	2003	We investigated the relationship between CREB and ischemic tolerance in gerbil hippocampal CA1 neurons using CRE decoy oligonucleotide.	Oligonucleotides	119-134	cAMP responsive element binding protein 1	Mus musculus	41-45
12887679-5	2003	The administration of CRE decoy oligonucleotide into gerbil cerebral ventricle decreased CREB-DNA binding activity to 38% of the control.	Oligonucleotides	32-47	cAMP responsive element binding protein 1	Mus musculus	89-93
12843281-3	2003	To examine whether estrogen may exert rapid actions on intracellular signaling within gonadotropin-releasing hormone (GnRH) neurons in vivo,we examined the phosphorylation status of cAMP response element-binding protein (CREB) in these cells after the administration of 17-beta-estradiol to ovariectomized (OVX) mice.	Estradiol	270-287	cAMP responsive element binding protein 1	Mus musculus	221-225
12842910-0	2003	cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.	Cyclic AMP	0-4	cAMP responsive element binding protein 1	Mus musculus	48-52
12807421-5	2003	Removal of Mg2+ also resulted in induction of the MAPK/ERK substrate mitogen- and stress-response kinase 1 (MSK1) and induced phosphorylation of the MSK1 substrate, the transcription factor cAMP response element binding protein (CREB).	magnesium ion	11-15	cAMP responsive element binding protein 1	Mus musculus	190-227
12807421-5	2003	Removal of Mg2+ also resulted in induction of the MAPK/ERK substrate mitogen- and stress-response kinase 1 (MSK1) and induced phosphorylation of the MSK1 substrate, the transcription factor cAMP response element binding protein (CREB).	magnesium ion	11-15	cAMP responsive element binding protein 1	Mus musculus	229-233
12871586-3	2003	Administration of the typical anti-psychotic haloperidol stimulated the phosphorylation of ERK1/2, CREB and Elk-1.	Haloperidol	45-56	cAMP responsive element binding protein 1	Mus musculus	99-103
12871586-5	2003	In contrast, the atypical anti-psychotic clozapine reduced ERK1/2, CREB and Elk-1 phosphorylation.	Clozapine	41-50	cAMP responsive element binding protein 1	Mus musculus	67-71
12871586-6	2003	This opposite regulation was specifically exerted by haloperidol and clozapine on ERK, CREB, and Elk-1 phosphorylation, as both anti-psychotic drugs increased the phosphorylation of the dopamine- and cyclic AMP-regulated phosphoprotein of 32 kDa (DARPP-32) at the cyclic AMP-dependent protein kinase (PKA) site.	Haloperidol	53-64	cAMP responsive element binding protein 1	Mus musculus	87-91
12871586-6	2003	This opposite regulation was specifically exerted by haloperidol and clozapine on ERK, CREB, and Elk-1 phosphorylation, as both anti-psychotic drugs increased the phosphorylation of the dopamine- and cyclic AMP-regulated phosphoprotein of 32 kDa (DARPP-32) at the cyclic AMP-dependent protein kinase (PKA) site.	Clozapine	69-78	cAMP responsive element binding protein 1	Mus musculus	87-91
12871586-7	2003	The activation of CREB and Elk-1 induced by haloperidol appeared to be achieved via different signalling pathways, as inhibition of ERK1/2 activation abolished the stimulation of Elk-1 phosphorylation without affecting CREB phosphorylation.	Haloperidol	44-55	cAMP responsive element binding protein 1	Mus musculus	18-22
12679364-7	2003	The active phospho form (serine 133) of CREB diminished significantly (p &lt; 0.01) in cells exposed to cytokines.	Serine	25-31	cAMP responsive element binding protein 1	Mus musculus	40-44
12790807-1	2003	Transcriptional induction by cAMP is mediated through the interaction of the cAMP response-element binding protein (CREB) with a cAMP response element (CRE) in the promoter of target genes.	Cyclic AMP	29-33	cAMP responsive element binding protein 1	Mus musculus	77-114
12790807-1	2003	Transcriptional induction by cAMP is mediated through the interaction of the cAMP response-element binding protein (CREB) with a cAMP response element (CRE) in the promoter of target genes.	Cyclic AMP	29-33	cAMP responsive element binding protein 1	Mus musculus	116-120
12790807-1	2003	Transcriptional induction by cAMP is mediated through the interaction of the cAMP response-element binding protein (CREB) with a cAMP response element (CRE) in the promoter of target genes.	Cyclic AMP	77-81	cAMP responsive element binding protein 1	Mus musculus	116-120
12790807-4	2003	Here we show that CREB and CREMtau (but not CREMalpha and CREMbeta) have qualitatively similar effects on StAR promoter activity in response to (Bu)(2)cAMP.	Cyclic AMP	151-155	cAMP responsive element binding protein 1	Mus musculus	18-22
12790807-5	2003	Studies on the effects of the functional integrity of the CRE half-sites on CREB-dependent (Bu)(2)cAMP-mediated StAR gene transcription demonstrated the greater importance of the CRE2 site in comparison with the CRE1 and CRE3 sites.	Cyclic AMP	98-102	cAMP responsive element binding protein 1	Mus musculus	76-80
12878189-0	2003	SP600125, an inhibitor of c-jun N-terminal kinase, activates CREB by a p38 MAPK-mediated pathway.	pyrazolanthrone	0-8	cAMP responsive element binding protein 1	Mus musculus	61-65
12878189-3	2003	SP600125 induced CREB-dependent promoter activation by 2.8-fold at 20 microM, the concentration at which it inhibited c-jun-dependent promoter activation by 51%.	pyrazolanthrone	0-8	cAMP responsive element binding protein 1	Mus musculus	17-21
12878189-4	2003	There was a significant (P&lt;0.01) increase in CREB phosphorylation (serine 133) at 5 min, which persisted for a period of 2h.	Serine	70-76	cAMP responsive element binding protein 1	Mus musculus	48-52
12878189-7	2003	SB203580, an inhibitor of p38 MAPK, partially blocked SP600125-mediated activation of CREB.	SB 203580	0-8	cAMP responsive element binding protein 1	Mus musculus	86-90
12878189-7	2003	SB203580, an inhibitor of p38 MAPK, partially blocked SP600125-mediated activation of CREB.	pyrazolanthrone	54-62	cAMP responsive element binding protein 1	Mus musculus	86-90
12878189-8	2003	These observations suggest that SP600125 could be used as a small molecular weight activator of CREB.	pyrazolanthrone	32-40	cAMP responsive element binding protein 1	Mus musculus	96-100
12966313-8	2003	The development of tolerance to the sedative effects of ethanol was accompanied by increased expression of phospho-CREB in the cerebellum, hippocampus, and frontal cortex.	Ethanol	56-63	cAMP responsive element binding protein 1	Mus musculus	115-119
12966313-12	2003	The mechanism through which cAMP/PKA signaling modulates the development of tolerance remains to be elucidated but may involve changes in phospho-CREB expression.	Cyclic AMP	28-32	cAMP responsive element binding protein 1	Mus musculus	146-150
12649327-8	2003	This study demonstrates that reduction of PTP1B protein using ASO reduces activation of p38 and its substrates TNFalpha and CREB in liver of diabetic mice, which correlates with decreased hyperglycemia and hyperinsulinemia.	Oligonucleotides, Antisense	62-65	cAMP responsive element binding protein 1	Mus musculus	124-128
12672056-3	2003	Stimulation through BCR resulted in dose-dependent induction of CREB-1 binding to the consensus cyclic AMP-responsive element.	Cyclic AMP	96-106	cAMP responsive element binding protein 1	Mus musculus	64-70
12670506-5	2003	The butyrate effect was shown to be dependent on caspase activation, once caspase inhibitors restored phosphorylation of ERK1/2 and CREB in 2C4 cells.	Butyrates	4-12	cAMP responsive element binding protein 1	Mus musculus	132-136
12670506-7	2003	In conclusion, butyrate induced apoptosis in 2C4 cells is regulated by the levels of ERK1/2 and CREB phosphorylation in a caspase dependent mechanism.	Butyrates	15-23	cAMP responsive element binding protein 1	Mus musculus	96-100
12689763-3	2003	A recent study using mice carrying a mutation in a specific tyrosine residue of trkB pinpoints a necessary role for the phospholipase-Cgamma (PLCgamma) pathway in CREB activation and LTP maintenance.	Tyrosine	60-68	cAMP responsive element binding protein 1	Mus musculus	163-167
12557267-1	2003	Previous work has demonstrated that acute and chronic administration of amphetamine causes phosphorylation of the transcription factor CREB, the cAMP response element (CRE) binding protein, in striatum, a brain region important for the behavioral actions of the drug.	Amphetamine	72-83	cAMP responsive element binding protein 1	Mus musculus	135-139
12557267-1	2003	Previous work has demonstrated that acute and chronic administration of amphetamine causes phosphorylation of the transcription factor CREB, the cAMP response element (CRE) binding protein, in striatum, a brain region important for the behavioral actions of the drug.	Cyclic AMP	145-149	cAMP responsive element binding protein 1	Mus musculus	135-139
12405989-7	2002	Further, activation of the ACVIII promoter by forskolin was potentiated by expression of a constitutively active form of CREB, CREB-VP16, whereas it was inhibited by expression of a dominant-negative form of CREB, A-CREB.	Colforsin	46-55	cAMP responsive element binding protein 1	Mus musculus	121-125
12614343-0	2003	In vivo nicotine treatment regulates mesocorticolimbic CREB and ERK signaling in C57Bl/6J mice.	Nicotine	8-16	cAMP responsive element binding protein 1	Mus musculus	55-59
12614343-4	2003	CREB phosphorylation was reduced in the nucleus accumbens following chronic nicotine, consistent with previous reports that decreased accumbens CREB activity increases drug reinforcement.	Nicotine	76-84	cAMP responsive element binding protein 1	Mus musculus	0-4
12614343-4	2003	CREB phosphorylation was reduced in the nucleus accumbens following chronic nicotine, consistent with previous reports that decreased accumbens CREB activity increases drug reinforcement.	Nicotine	76-84	cAMP responsive element binding protein 1	Mus musculus	144-148
12614343-5	2003	In contrast, CREB phosphorylation was increased in the prefrontal cortex following chronic nicotine exposure and in the ventral tegmental area during nicotine withdrawal.	Nicotine	91-99	cAMP responsive element binding protein 1	Mus musculus	13-17
12614343-5	2003	In contrast, CREB phosphorylation was increased in the prefrontal cortex following chronic nicotine exposure and in the ventral tegmental area during nicotine withdrawal.	Nicotine	150-158	cAMP responsive element binding protein 1	Mus musculus	13-17
12614343-8	2003	Overall, these results support a role for ERK and CREB activity in neural plasticity associated with nicotine dependence.	Nicotine	101-109	cAMP responsive element binding protein 1	Mus musculus	50-54
12643347-6	2003	Ketamine could suppress not only the place preference but also the phosphorylation of CREB produced by morphine, F9202 and F9204.	Ketamine	0-8	cAMP responsive element binding protein 1	Mus musculus	86-90
12643347-6	2003	Ketamine could suppress not only the place preference but also the phosphorylation of CREB produced by morphine, F9202 and F9204.	Morphine	103-111	cAMP responsive element binding protein 1	Mus musculus	86-90
12521295-9	2002	Both MK-801 and CNQX attenuated, in part, the increased p-ERK and the decreased p-CREB induced by KA.	Dizocilpine Maleate	5-11	cAMP responsive element binding protein 1	Mus musculus	82-86
12521295-9	2002	Both MK-801 and CNQX attenuated, in part, the increased p-ERK and the decreased p-CREB induced by KA.	6-Cyano-7-nitroquinoxaline-2,3-dione	16-20	cAMP responsive element binding protein 1	Mus musculus	82-86
12471138-5	2002	Similarly, selective inhibition of cAMP and NF-kappaB strongly down-regulated the induction of all chemokine transcripts as well as CREB and NF-kappaB activation, respectively.	Cyclic AMP	35-39	cAMP responsive element binding protein 1	Mus musculus	132-136
12471138-6	2002	Of interest, we detected a significant decrease of NF-kappaB, AP-1, and CREB DNA binding activities by reciprocal competition for these binding sites when either specific cold oligonucleotides (NF-kappaB, AP-1, and CREB) or Abs against various transcription factor subunits (p50, p65, c-Fos, Jun B, c-Jun, and CREB-1) were added.	Oligonucleotides	176-192	cAMP responsive element binding protein 1	Mus musculus	72-76
12471138-6	2002	Of interest, we detected a significant decrease of NF-kappaB, AP-1, and CREB DNA binding activities by reciprocal competition for these binding sites when either specific cold oligonucleotides (NF-kappaB, AP-1, and CREB) or Abs against various transcription factor subunits (p50, p65, c-Fos, Jun B, c-Jun, and CREB-1) were added.	Oligonucleotides	176-192	cAMP responsive element binding protein 1	Mus musculus	215-219
12471138-6	2002	Of interest, we detected a significant decrease of NF-kappaB, AP-1, and CREB DNA binding activities by reciprocal competition for these binding sites when either specific cold oligonucleotides (NF-kappaB, AP-1, and CREB) or Abs against various transcription factor subunits (p50, p65, c-Fos, Jun B, c-Jun, and CREB-1) were added.	Oligonucleotides	176-192	cAMP responsive element binding protein 1	Mus musculus	310-316
12374787-1	2002	The cAMP-response element-binding protein (CREB) is activated by phosphorylation on serine 133 and mediates the proliferative response to a number of different signals.	Serine	84-90	cAMP responsive element binding protein 1	Mus musculus	4-41
12374787-1	2002	The cAMP-response element-binding protein (CREB) is activated by phosphorylation on serine 133 and mediates the proliferative response to a number of different signals.	Serine	84-90	cAMP responsive element binding protein 1	Mus musculus	43-47
12658356-9	2002	CREB was detected in hepatocyte nuclei in autoclaved paraffin sections by Southwestern histochemistry.	Paraffin	53-61	cAMP responsive element binding protein 1	Mus musculus	0-4
12658356-12	2002	Because the PCNA gene has a cAMP-responsive element in its promoter, it can be suggested that CREB may activate the PCNA gene and lead to the induction of hepatocyte DNA synthesis.	Cyclic AMP	28-32	cAMP responsive element binding protein 1	Mus musculus	94-98
12670506-0	2003	Inhibition of ERK1/2 and CREB phosphorylation by caspase-dependent mechanism enhances apoptosis in a fibrosarcoma cell line treated with butyrate.	Butyrates	137-145	cAMP responsive element binding protein 1	Mus musculus	25-29
12670506-3	2003	Butyrate inhibited phosphorylation of ERK1/2 and CREB.	Butyrates	0-8	cAMP responsive element binding protein 1	Mus musculus	49-53
12670506-4	2003	Furthermore, the use of specific inhibitors PD98059 (MEK) and H89 (PKA), which block ERK1/2 and CREB phosphorylation, accelerated butyrate induced cell death in 2C4 cells.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	44-51	cAMP responsive element binding protein 1	Mus musculus	96-100
12464395-7	2003	Treatment of cells with forskolin, a stimulator of adenylate cyclase, increased the amount of phosphorylated CREB and CBP, but not the amount of phosphorylated Smad2 bound in a complex to the SBE.	Colforsin	24-33	cAMP responsive element binding protein 1	Mus musculus	109-113
12643347-0	2003	Ohmefentanyl stereoisomers induce changes of CREB phosphorylation in hippocampus of mice in conditioned place preference paradigm.	F 7302	0-12	cAMP responsive element binding protein 1	Mus musculus	45-49
12643347-1	2003	The present study was designed to determine the changes of phosphorylation of cAMP- response element binding protein (CREB) in hippocampus induced by ohmefentanyl stereoisomers (F9202 and F9204) in conditioned place preference (CPP) paradigm.	F 7302	150-162	cAMP responsive element binding protein 1	Mus musculus	78-116
12643347-1	2003	The present study was designed to determine the changes of phosphorylation of cAMP- response element binding protein (CREB) in hippocampus induced by ohmefentanyl stereoisomers (F9202 and F9204) in conditioned place preference (CPP) paradigm.	F 7302	150-162	cAMP responsive element binding protein 1	Mus musculus	118-122
12504868-6	2003	In addition, DNA-binding activities of NF-kappaB, AP-1, and CREB in the frontal cortex and hippocampus were more pronounced in mice injected with Tat plus METH compared to the effects of Tat or METH alone.	Methamphetamine	155-159	cAMP responsive element binding protein 1	Mus musculus	60-64
12388835-1	2002	Regulation of gene expression via the protein kinase A (PKA) pathway is mediated through Ser133 phosphorylation of the transcription factor (TF), cAMP response element (CRE) binding protein (CREB).	Cyclic AMP	146-150	cAMP responsive element binding protein 1	Mus musculus	191-195
12388835-2	2002	Secalonic acid D (SAD), a mycotoxin causing cleft palate (CP), induces phosphorylation of palatal CREB in vivo.	secalonic acid	0-16	cAMP responsive element binding protein 1	Mus musculus	98-102
12405989-7	2002	Further, activation of the ACVIII promoter by forskolin was potentiated by expression of a constitutively active form of CREB, CREB-VP16, whereas it was inhibited by expression of a dominant-negative form of CREB, A-CREB.	Colforsin	46-55	cAMP responsive element binding protein 1	Mus musculus	127-131
12405989-7	2002	Further, activation of the ACVIII promoter by forskolin was potentiated by expression of a constitutively active form of CREB, CREB-VP16, whereas it was inhibited by expression of a dominant-negative form of CREB, A-CREB.	Colforsin	46-55	cAMP responsive element binding protein 1	Mus musculus	127-131
12405989-7	2002	Further, activation of the ACVIII promoter by forskolin was potentiated by expression of a constitutively active form of CREB, CREB-VP16, whereas it was inhibited by expression of a dominant-negative form of CREB, A-CREB.	Colforsin	46-55	cAMP responsive element binding protein 1	Mus musculus	127-131
12237866-4	2002	Significant and dose-dependent inductions of AP-1 and CREB DNA-binding activities were observed in four different regions (striatum, frontal cortex, hippocampus, and cerebellum) isolated from the brains of mice injected with METH.	Methamphetamine	225-229	cAMP responsive element binding protein 1	Mus musculus	54-58
12237866-6	2002	These results suggest that METH-induced oxidative stress may trigger the molecular signaling pathways via specific and selective activation of AP-1 and CREB.	Methamphetamine	27-31	cAMP responsive element binding protein 1	Mus musculus	152-156
12114513-3	2002	We now report that a significant elevation of cAMP-response element-binding protein (CREB) occurs in alpha(2)M*-stimulated cells, and this effect is potentiated by isobutylmethylxanthine, dibutyryl-cAMP, or forskolin.	1-Methyl-3-isobutylxanthine	164-186	cAMP responsive element binding protein 1	Mus musculus	46-83
12114513-3	2002	We now report that a significant elevation of cAMP-response element-binding protein (CREB) occurs in alpha(2)M*-stimulated cells, and this effect is potentiated by isobutylmethylxanthine, dibutyryl-cAMP, or forskolin.	1-Methyl-3-isobutylxanthine	164-186	cAMP responsive element binding protein 1	Mus musculus	85-89
12114513-3	2002	We now report that a significant elevation of cAMP-response element-binding protein (CREB) occurs in alpha(2)M*-stimulated cells, and this effect is potentiated by isobutylmethylxanthine, dibutyryl-cAMP, or forskolin.	Bucladesine	188-202	cAMP responsive element binding protein 1	Mus musculus	46-83
12114513-3	2002	We now report that a significant elevation of cAMP-response element-binding protein (CREB) occurs in alpha(2)M*-stimulated cells, and this effect is potentiated by isobutylmethylxanthine, dibutyryl-cAMP, or forskolin.	Bucladesine	188-202	cAMP responsive element binding protein 1	Mus musculus	85-89
12114513-3	2002	We now report that a significant elevation of cAMP-response element-binding protein (CREB) occurs in alpha(2)M*-stimulated cells, and this effect is potentiated by isobutylmethylxanthine, dibutyryl-cAMP, or forskolin.	Colforsin	207-216	cAMP responsive element binding protein 1	Mus musculus	46-83
12114513-3	2002	We now report that a significant elevation of cAMP-response element-binding protein (CREB) occurs in alpha(2)M*-stimulated cells, and this effect is potentiated by isobutylmethylxanthine, dibutyryl-cAMP, or forskolin.	Colforsin	207-216	cAMP responsive element binding protein 1	Mus musculus	85-89
12114513-4	2002	An alpha(2)M* concentration-dependent rapid increase in phosphorylated CREB at Ser(133) also occurred, a necessary event in its activation.	Serine	79-82	cAMP responsive element binding protein 1	Mus musculus	71-75
12059784-6	2002	The phosphorylation of CREB, ATF1 and MAPKAP-K2 were inhibited by SB203580, a p38MAPK inhibitor, but not by PD98059, an ERK kinase inhibitor.	SB 203580	66-74	cAMP responsive element binding protein 1	Mus musculus	23-27
12084707-7	2002	Additionally, Western blot analysis for phospho-CREB/ATF1 shows an increase in phosphorylation of CREB/ATF1 in HIB-1B cells after norepinephrine treatment.	Norepinephrine	130-144	cAMP responsive element binding protein 1	Mus musculus	98-102
12220541-7	2002	Activation of a StRE-dependent luciferase gene by arsenite was inhibited to varying degrees by dominant-negative mutants of Nrf2, MafK, c-Fos, and CREB but most strongly with the latter.	arsenite	50-58	cAMP responsive element binding protein 1	Mus musculus	147-151
12175701-8	2002	Treatment of primary cultures of murine embryonic palate mesenchymal (MEPM) cells with forskolin (20 microM) to elevate intracellular cAMP levels, resulted in a time-dependent increase in CREB ser-133 phosphorylation and a corresponding time dependent decrease in PP-1 and PP-2A levels.	Colforsin	87-96	cAMP responsive element binding protein 1	Mus musculus	188-192
12175701-8	2002	Treatment of primary cultures of murine embryonic palate mesenchymal (MEPM) cells with forskolin (20 microM) to elevate intracellular cAMP levels, resulted in a time-dependent increase in CREB ser-133 phosphorylation and a corresponding time dependent decrease in PP-1 and PP-2A levels.	Cyclic AMP	134-138	cAMP responsive element binding protein 1	Mus musculus	188-192
12175701-8	2002	Treatment of primary cultures of murine embryonic palate mesenchymal (MEPM) cells with forskolin (20 microM) to elevate intracellular cAMP levels, resulted in a time-dependent increase in CREB ser-133 phosphorylation and a corresponding time dependent decrease in PP-1 and PP-2A levels.	Serine	193-196	cAMP responsive element binding protein 1	Mus musculus	188-192
12205148-4	2002	Both the potentiation and the increase in phospho-CREB immunofluorescence induced by multiple-train tetanization or 8-Br-cGMP paired with one-train tetanization are reduced by prolonged perfusion with ryanodine, which blocks Ca(2+) release from ryanodine-sensitive Ca(2+) stores.	Ryanodine	245-254	cAMP responsive element binding protein 1	Mus musculus	50-54
12193547-7	2002	In addition, phosphorylation of the cAMP responsive element binding protein (CREB) was not detected following 50 micro M cAMP exposure, a concentration sufficient for Cyp17 mRNA induction.	Cyclic AMP	36-40	cAMP responsive element binding protein 1	Mus musculus	77-81
12193547-8	2002	Moreover, CREB phosphorylation, which was observed with addition of 500 micro M cAMP, was not inhibited by coincubation with MIS.	Cyclic AMP	80-84	cAMP responsive element binding protein 1	Mus musculus	10-14
12205148-0	2002	Ryanodine receptors contribute to cGMP-induced late-phase LTP and CREB phosphorylation in the hippocampus.	Cyclic GMP	34-38	cAMP responsive element binding protein 1	Mus musculus	66-70
12205148-1	2002	We previously found that the nitric oxide (NO)-cGMP-cGMP-dependent protein kinase (PKG) signaling pathway acts in parallel with the cAMP-cAMP-dependent protein kinase (PKA) pathway to produce protein and RNA synthesis-dependent late-phase long-term potentiation (L-LTP) and cAMP response element-binding protein (CREB) phosphorylation in the CA1 region of mouse hippocampus.	Nitric Oxide	29-41	cAMP responsive element binding protein 1	Mus musculus	274-311
12205148-1	2002	We previously found that the nitric oxide (NO)-cGMP-cGMP-dependent protein kinase (PKG) signaling pathway acts in parallel with the cAMP-cAMP-dependent protein kinase (PKA) pathway to produce protein and RNA synthesis-dependent late-phase long-term potentiation (L-LTP) and cAMP response element-binding protein (CREB) phosphorylation in the CA1 region of mouse hippocampus.	Nitric Oxide	29-41	cAMP responsive element binding protein 1	Mus musculus	313-317
12205148-1	2002	We previously found that the nitric oxide (NO)-cGMP-cGMP-dependent protein kinase (PKG) signaling pathway acts in parallel with the cAMP-cAMP-dependent protein kinase (PKA) pathway to produce protein and RNA synthesis-dependent late-phase long-term potentiation (L-LTP) and cAMP response element-binding protein (CREB) phosphorylation in the CA1 region of mouse hippocampus.	Cyclic GMP	47-51	cAMP responsive element binding protein 1	Mus musculus	274-311
12205148-1	2002	We previously found that the nitric oxide (NO)-cGMP-cGMP-dependent protein kinase (PKG) signaling pathway acts in parallel with the cAMP-cAMP-dependent protein kinase (PKA) pathway to produce protein and RNA synthesis-dependent late-phase long-term potentiation (L-LTP) and cAMP response element-binding protein (CREB) phosphorylation in the CA1 region of mouse hippocampus.	Cyclic GMP	47-51	cAMP responsive element binding protein 1	Mus musculus	313-317
12205148-1	2002	We previously found that the nitric oxide (NO)-cGMP-cGMP-dependent protein kinase (PKG) signaling pathway acts in parallel with the cAMP-cAMP-dependent protein kinase (PKA) pathway to produce protein and RNA synthesis-dependent late-phase long-term potentiation (L-LTP) and cAMP response element-binding protein (CREB) phosphorylation in the CA1 region of mouse hippocampus.	Cyclic AMP	132-136	cAMP responsive element binding protein 1	Mus musculus	274-311
12205148-1	2002	We previously found that the nitric oxide (NO)-cGMP-cGMP-dependent protein kinase (PKG) signaling pathway acts in parallel with the cAMP-cAMP-dependent protein kinase (PKA) pathway to produce protein and RNA synthesis-dependent late-phase long-term potentiation (L-LTP) and cAMP response element-binding protein (CREB) phosphorylation in the CA1 region of mouse hippocampus.	Cyclic AMP	132-136	cAMP responsive element binding protein 1	Mus musculus	313-317
12205148-4	2002	Both the potentiation and the increase in phospho-CREB immunofluorescence induced by multiple-train tetanization or 8-Br-cGMP paired with one-train tetanization are reduced by prolonged perfusion with ryanodine, which blocks Ca(2+) release from ryanodine-sensitive Ca(2+) stores.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	116-125	cAMP responsive element binding protein 1	Mus musculus	50-54
12205148-4	2002	Both the potentiation and the increase in phospho-CREB immunofluorescence induced by multiple-train tetanization or 8-Br-cGMP paired with one-train tetanization are reduced by prolonged perfusion with ryanodine, which blocks Ca(2+) release from ryanodine-sensitive Ca(2+) stores.	Ryanodine	201-210	cAMP responsive element binding protein 1	Mus musculus	50-54
12198546-7	2002	The enhanced learning correlates with increased phosphorylation of cyclic AMP-dependent response element binding (CREB) protein, of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and of the GluR1 subunit of the AMPA receptor; it also correlates with CREB-dependent gene expression that, in control mice, occurs only with widely distributed training.	Cyclic AMP	67-77	cAMP responsive element binding protein 1	Mus musculus	114-118
12198546-7	2002	The enhanced learning correlates with increased phosphorylation of cyclic AMP-dependent response element binding (CREB) protein, of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and of the GluR1 subunit of the AMPA receptor; it also correlates with CREB-dependent gene expression that, in control mice, occurs only with widely distributed training.	Cyclic AMP	67-77	cAMP responsive element binding protein 1	Mus musculus	258-262
12165570-1	2002	The transcription factor cAMP response element (CRE)-binding protein (CREB) has been shown to regulate neural plasticity.	Cyclic AMP	25-29	cAMP responsive element binding protein 1	Mus musculus	70-74
12165570-2	2002	Drugs of abuse activate CREB in the nucleus accumbens, an important part of the brain"s reward pathways, and local manipulations of CREB activity have been shown to affect cocaine reward, suggesting an active role of CREB in adaptive processes that follow exposure to drugs of abuse.	Cocaine	172-179	cAMP responsive element binding protein 1	Mus musculus	132-136
12165570-2	2002	Drugs of abuse activate CREB in the nucleus accumbens, an important part of the brain"s reward pathways, and local manipulations of CREB activity have been shown to affect cocaine reward, suggesting an active role of CREB in adaptive processes that follow exposure to drugs of abuse.	Cocaine	172-179	cAMP responsive element binding protein 1	Mus musculus	132-136
12165570-4	2002	Using viral-mediated gene transfer to locally alter the activity of CREB, we show that this manipulation affects morphine reward, as well as the preference for sucrose, a more natural reward.	Morphine	113-121	cAMP responsive element binding protein 1	Mus musculus	68-72
12165570-4	2002	Using viral-mediated gene transfer to locally alter the activity of CREB, we show that this manipulation affects morphine reward, as well as the preference for sucrose, a more natural reward.	Sucrose	160-167	cAMP responsive element binding protein 1	Mus musculus	68-72
12163474-5	2002	In MAP2-deficient cultured neurons, the induction rate of phosphorylated CREB after forskolin stimulation was much lower than in wild-type neurons.	Colforsin	84-93	cAMP responsive element binding protein 1	Mus musculus	73-77
12130557-8	2002	In Ob/Ob mice (which demonstrate reduced aortic wall CREB content vs. Ob/- controls), treatment with the peroxisomal proliferator-activated receptor gamma rosiglitazone increases CREB content and decreases PDGFRalpha content in the aortic wall.	Rosiglitazone	155-168	cAMP responsive element binding protein 1	Mus musculus	53-57
12212777-2	2002	Experiments focused on the cAMP-responsive transcription factor, CREB, have established that neural activity-induced regulation of gene transcription promotes a synaptic growth process that strengthens the connections among active neurons.	Cyclic AMP	27-31	cAMP responsive element binding protein 1	Mus musculus	65-69
12205148-6	2002	These results suggest that NO, cGMP, and PKG cause release of Ca(2+) from ryanodine-sensitive stores, which in turn causes phosphorylation of CREB in parallel with PKA during the induction of L-LTP.	Cyclic GMP	31-35	cAMP responsive element binding protein 1	Mus musculus	142-146
12205148-6	2002	These results suggest that NO, cGMP, and PKG cause release of Ca(2+) from ryanodine-sensitive stores, which in turn causes phosphorylation of CREB in parallel with PKA during the induction of L-LTP.	Ryanodine	74-83	cAMP responsive element binding protein 1	Mus musculus	142-146
12190109-6	2002	The phosphorylation of the nuclear transcription factor CREB phosphorylation at Ser 133 was not significantly changed in either skeletal or cardiac muscle.	Serine	80-83	cAMP responsive element binding protein 1	Mus musculus	56-60
12084707-7	2002	Additionally, Western blot analysis for phospho-CREB/ATF1 shows an increase in phosphorylation of CREB/ATF1 in HIB-1B cells after norepinephrine treatment.	Norepinephrine	130-144	cAMP responsive element binding protein 1	Mus musculus	48-52
12021407-3	2002	Different patterns of CREB overexpression were found in striatum, nucleus accumbens, and cingulate cortex in different lines of bitransgenic mice, and CREB expression was blocked by addition of doxycycline, an analog of tetracycline.	Tetracycline	220-232	cAMP responsive element binding protein 1	Mus musculus	151-155
12113781-6	2002	Inducible transgenic mice that express either a dominant negative mutant form of the cAMP response element binding protein (mCREB) or CREB, in discrete brain regions, were used in this study.	Cyclic AMP	85-89	cAMP responsive element binding protein 1	Mus musculus	124-129
12021407-1	2002	To investigate the role of cAMP response element-binding protein (CREB) in the adaptive responses to psychotropic drugs, we have developed inducible, brain region-specific CREB transgenic mice using the tetracycline-regulated gene expression system.	Tetracycline	203-215	cAMP responsive element binding protein 1	Mus musculus	66-70
12021407-6	2002	Finally, there was a significant reduction in cocaine-induced locomotor activity in the CREB bitransgenic mice.	Cocaine	46-53	cAMP responsive element binding protein 1	Mus musculus	88-92
12021407-1	2002	To investigate the role of cAMP response element-binding protein (CREB) in the adaptive responses to psychotropic drugs, we have developed inducible, brain region-specific CREB transgenic mice using the tetracycline-regulated gene expression system.	Tetracycline	203-215	cAMP responsive element binding protein 1	Mus musculus	172-176
11886856-1	2002	We have shown that ethanol induces translocation of cAMP-dependent protein kinase (PKA) to the nucleus, cAMP response element-binding protein (CREB) phosphorylation, and cAMP response element-mediated gene transcription in NG108-15 cells.	Ethanol	19-26	cAMP responsive element binding protein 1	Mus musculus	104-141
12021407-3	2002	Different patterns of CREB overexpression were found in striatum, nucleus accumbens, and cingulate cortex in different lines of bitransgenic mice, and CREB expression was blocked by addition of doxycycline, an analog of tetracycline.	Doxycycline	194-205	cAMP responsive element binding protein 1	Mus musculus	22-26
12021407-3	2002	Different patterns of CREB overexpression were found in striatum, nucleus accumbens, and cingulate cortex in different lines of bitransgenic mice, and CREB expression was blocked by addition of doxycycline, an analog of tetracycline.	Doxycycline	194-205	cAMP responsive element binding protein 1	Mus musculus	151-155
12021407-3	2002	Different patterns of CREB overexpression were found in striatum, nucleus accumbens, and cingulate cortex in different lines of bitransgenic mice, and CREB expression was blocked by addition of doxycycline, an analog of tetracycline.	Tetracycline	220-232	cAMP responsive element binding protein 1	Mus musculus	22-26
11886856-6	2002	Our data suggest that forskolin- and ethanol-induced CREB phosphorylation and gene activation are differentially mediated by the two types of PKA.	Colforsin	22-31	cAMP responsive element binding protein 1	Mus musculus	53-57
12032351-9	2002	On the other hand, only mPer1 and mPer2 promoters contain bona fide cAMP-responsive elements (CREs) that bind CRE-binding protein (CREB) from suprachiasmatic nucleus protein extracts.	Cyclic AMP	68-72	cAMP responsive element binding protein 1	Mus musculus	110-129
12032351-9	2002	On the other hand, only mPer1 and mPer2 promoters contain bona fide cAMP-responsive elements (CREs) that bind CRE-binding protein (CREB) from suprachiasmatic nucleus protein extracts.	Cyclic AMP	68-72	cAMP responsive element binding protein 1	Mus musculus	131-135
11886856-6	2002	Our data suggest that forskolin- and ethanol-induced CREB phosphorylation and gene activation are differentially mediated by the two types of PKA.	Ethanol	37-44	cAMP responsive element binding protein 1	Mus musculus	53-57
11886856-1	2002	We have shown that ethanol induces translocation of cAMP-dependent protein kinase (PKA) to the nucleus, cAMP response element-binding protein (CREB) phosphorylation, and cAMP response element-mediated gene transcription in NG108-15 cells.	Ethanol	19-26	cAMP responsive element binding protein 1	Mus musculus	143-147
11886856-5	2002	However, only the type II PKA antagonist inhibits forskolin-induced Calpha and ethanol-induced Calpha and RIIbeta translocation to the nucleus and CREB phosphorylation; the type I antagonist is without effect.	Colforsin	50-59	cAMP responsive element binding protein 1	Mus musculus	147-151
11886856-5	2002	However, only the type II PKA antagonist inhibits forskolin-induced Calpha and ethanol-induced Calpha and RIIbeta translocation to the nucleus and CREB phosphorylation; the type I antagonist is without effect.	Ethanol	79-86	cAMP responsive element binding protein 1	Mus musculus	147-151
11988078-2	2002	We found that noradrenaline ("norepinephrine") stimulated CREB phosphorylation rapidly (maximum effect in &lt; or =5 min with slow decay) and efficiently (EC(50), 6 nM).	Norepinephrine	14-27	cAMP responsive element binding protein 1	Mus musculus	58-62
11988078-2	2002	We found that noradrenaline ("norepinephrine") stimulated CREB phosphorylation rapidly (maximum effect in &lt; or =5 min with slow decay) and efficiently (EC(50), 6 nM).	Norepinephrine	30-44	cAMP responsive element binding protein 1	Mus musculus	58-62
11988078-3	2002	The increase in CREB phosphorylation coincided with increased expression of an artificial cAMP-response-element-containing reporter construct.	Cyclic AMP	90-94	cAMP responsive element binding protein 1	Mus musculus	16-20
11988078-4	2002	CREB phosphorylation was partly inhibitable, both by the beta-adrenergic antagonist propranolol and by the alpha(1)-adrenergic antagonist prazosin.	Propranolol	84-95	cAMP responsive element binding protein 1	Mus musculus	0-4
11988078-4	2002	CREB phosphorylation was partly inhibitable, both by the beta-adrenergic antagonist propranolol and by the alpha(1)-adrenergic antagonist prazosin.	Prazosin	138-146	cAMP responsive element binding protein 1	Mus musculus	0-4
11988078-5	2002	Adenylate cyclase hyperactivation (by forskolin) could stimulate CREB phosphorylation to the same extent as noradrenaline.	Colforsin	38-47	cAMP responsive element binding protein 1	Mus musculus	65-69
11988078-6	2002	The alpha(1)-adrenergic agonist cirazoline also increased CREB phosphorylation.	cirazoline	32-42	cAMP responsive element binding protein 1	Mus musculus	58-62
11988078-8	2002	The cirazoline-stimulated (alpha(1)-adrenergic) CREB phosphorylation was inhibited by a desensitizing pretreatment with PMA, demonstrating that the alpha(1)-stimulation was mediated via protein kinase C activation; neither Src nor extracellular-signal-regulated kinases 1 and 2 activation was involved in the signalling process.	cirazoline	4-14	cAMP responsive element binding protein 1	Mus musculus	48-52
11988078-8	2002	The cirazoline-stimulated (alpha(1)-adrenergic) CREB phosphorylation was inhibited by a desensitizing pretreatment with PMA, demonstrating that the alpha(1)-stimulation was mediated via protein kinase C activation; neither Src nor extracellular-signal-regulated kinases 1 and 2 activation was involved in the signalling process.	Tetradecanoylphorbol Acetate	120-123	cAMP responsive element binding protein 1	Mus musculus	48-52
11988078-9	2002	We conclude that CREB phosphorylation in brown adipocytes is mediated not only through the classical beta-adrenergic/cAMP pathway but also through a novel alpha(1)-adrenergic/protein kinase C/CREB pathway, which has not been described previously in any tissue.	Cyclic AMP	117-121	cAMP responsive element binding protein 1	Mus musculus	17-21
11978843-1	2002	The cAMP cascade, including the cAMP response element-binding protein (CREB), is known to play an important role in neuronal survival and plasticity.	Cyclic AMP	4-8	cAMP responsive element binding protein 1	Mus musculus	71-75
11969286-1	2002	Transcriptional factors binding to cAMP-responsive elements (CREs) in the promoters of various genes belong to the basic domain-leucine zipper superfamily and are composed of three genes in mammals, CREB, CREM, and ATF-1.	Cyclic AMP	35-39	cAMP responsive element binding protein 1	Mus musculus	199-203
11978843-7	2002	The results suggest that the cAMP-CREB cascade could contribute to the actions of neurotransmitters and neurotrophic factors on adult neurogenesis.	Cyclic AMP	29-33	cAMP responsive element binding protein 1	Mus musculus	34-38
11988169-2	2002	Here we show that CREB is phosphorylated on its transcriptional regulatory site, Ser-133, in vivo in a neurotrophin-dependent manner.	Serine	81-84	cAMP responsive element binding protein 1	Mus musculus	18-22
11967539-6	2002	The striatal phenotype is reminiscent of Huntington disease and is consistent with the postulated role of CREB-mediated signaling in polyglutamine-triggered diseases.	polyglutamine	133-146	cAMP responsive element binding protein 1	Mus musculus	106-110
11943827-6	2002	Furthermore, the ability of DMI to suppress an acute corticosterone response after swim stress is maintained in CREB-deficient mice.	Desipramine	28-31	cAMP responsive element binding protein 1	Mus musculus	112-116
11943827-6	2002	Furthermore, the ability of DMI to suppress an acute corticosterone response after swim stress is maintained in CREB-deficient mice.	Corticosterone	53-67	cAMP responsive element binding protein 1	Mus musculus	112-116
11943827-7	2002	However, upregulation of a molecular target of CREB, BDNF, is abolished in the CREB-deficient mice after chronic administration of DMI.	Desipramine	131-134	cAMP responsive element binding protein 1	Mus musculus	47-51
11943827-7	2002	However, upregulation of a molecular target of CREB, BDNF, is abolished in the CREB-deficient mice after chronic administration of DMI.	Desipramine	131-134	cAMP responsive element binding protein 1	Mus musculus	79-83
11564732-7	2001	Electrophoretic mobility shift assays demonstrated that transcription factors CREB/CREM and USF1/USF2 in As4.1 cell nuclear extracts bind to oligonucleotides containing the Ren-1(c) CRE and E-box, respectively.	Oligonucleotides	141-157	cAMP responsive element binding protein 1	Mus musculus	78-82
11956331-6	2002	Antisense oligonucleotides against CREB, GATA-2 and SOX-5 significantly reduced charge movement in C2C12 cells.	Oligonucleotides	10-26	cAMP responsive element binding protein 1	Mus musculus	35-39
11907158-3	2002	We have shown in the NG108-15 neuroblastoma x glioma hybrid cell line that ethanol increases cellular cAMP levels via activation of adenosine A(2) receptors, leading to phosphorylation of the cAMP response element-binding protein (CREB).	Ethanol	75-82	cAMP responsive element binding protein 1	Mus musculus	192-229
11907158-3	2002	We have shown in the NG108-15 neuroblastoma x glioma hybrid cell line that ethanol increases cellular cAMP levels via activation of adenosine A(2) receptors, leading to phosphorylation of the cAMP response element-binding protein (CREB).	Ethanol	75-82	cAMP responsive element binding protein 1	Mus musculus	231-235
11907158-3	2002	We have shown in the NG108-15 neuroblastoma x glioma hybrid cell line that ethanol increases cellular cAMP levels via activation of adenosine A(2) receptors, leading to phosphorylation of the cAMP response element-binding protein (CREB).	Cyclic AMP	102-106	cAMP responsive element binding protein 1	Mus musculus	192-229
11907158-5	2002	Here we investigate whether ethanol increases CRE-mediated gene expression via endogenous CREB using a CRE-regulated luciferase reporter construct, transfected into NG108-15 cells.	Ethanol	28-35	cAMP responsive element binding protein 1	Mus musculus	90-94
11907158-7	2002	Coexpression of a dominant-negative CREB construct blocked ethanol-stimulated CRE-luciferase expression, further suggesting that CREB is required for this response.	Ethanol	59-66	cAMP responsive element binding protein 1	Mus musculus	36-40
11907158-7	2002	Coexpression of a dominant-negative CREB construct blocked ethanol-stimulated CRE-luciferase expression, further suggesting that CREB is required for this response.	Ethanol	59-66	cAMP responsive element binding protein 1	Mus musculus	129-133
11907158-11	2002	Our data suggest that ethanol induces cAMP-dependent gene expression regulated by CREB and PKA and that this signaling pathway may mediate some of the addictive behaviors underlying alcoholism.	Ethanol	22-29	cAMP responsive element binding protein 1	Mus musculus	82-86
11907158-11	2002	Our data suggest that ethanol induces cAMP-dependent gene expression regulated by CREB and PKA and that this signaling pathway may mediate some of the addictive behaviors underlying alcoholism.	Cyclic AMP	38-42	cAMP responsive element binding protein 1	Mus musculus	82-86
11889468-2	2002	To define the role of CREB in distinct memory processes, we derived transgenic mice with an inducible and reversible CREB repressor by fusing CREBS133A to a tamoxifen (TAM)-dependent mutant of an estrogen receptor ligand-binding domain (LBD).	Tamoxifen	157-166	cAMP responsive element binding protein 1	Mus musculus	117-121
11889468-2	2002	To define the role of CREB in distinct memory processes, we derived transgenic mice with an inducible and reversible CREB repressor by fusing CREBS133A to a tamoxifen (TAM)-dependent mutant of an estrogen receptor ligand-binding domain (LBD).	Tamoxifen	168-171	cAMP responsive element binding protein 1	Mus musculus	117-121
11979726-5	2002	In conclusion, the results of mutant mice suggest that the alternation of catecholamine biosynthesis and cAMP signal pathways may play a key role in development of latent learning and morphine dependence, and they furthermore show that the expression of genes mediated by phosphorylated CREB may be involved in the development of latent learning and morphine dependence.	Catecholamines	74-87	cAMP responsive element binding protein 1	Mus musculus	287-291
11979726-5	2002	In conclusion, the results of mutant mice suggest that the alternation of catecholamine biosynthesis and cAMP signal pathways may play a key role in development of latent learning and morphine dependence, and they furthermore show that the expression of genes mediated by phosphorylated CREB may be involved in the development of latent learning and morphine dependence.	Cyclic AMP	105-109	cAMP responsive element binding protein 1	Mus musculus	287-291
11979726-5	2002	In conclusion, the results of mutant mice suggest that the alternation of catecholamine biosynthesis and cAMP signal pathways may play a key role in development of latent learning and morphine dependence, and they furthermore show that the expression of genes mediated by phosphorylated CREB may be involved in the development of latent learning and morphine dependence.	Morphine	184-192	cAMP responsive element binding protein 1	Mus musculus	287-291
11979726-5	2002	In conclusion, the results of mutant mice suggest that the alternation of catecholamine biosynthesis and cAMP signal pathways may play a key role in development of latent learning and morphine dependence, and they furthermore show that the expression of genes mediated by phosphorylated CREB may be involved in the development of latent learning and morphine dependence.	Morphine	350-358	cAMP responsive element binding protein 1	Mus musculus	287-291
11806972-1	2002	Activating transcription factor (ATF) 4 is a ubiquitous basic leucine-zipper transcription factor that is a member of the ATF/cyclic adenosine monophosphate responsive element-binding (CREB) protein family.	Cyclic AMP	126-156	cAMP responsive element binding protein 1	Mus musculus	185-189
11963968-4	2002	The linkage between cAMP and expression of specific genes is mediated via activation of trans-acting deoxyribonucleic acid-binding proteins such as the nuclear CREB.	Cyclic AMP	20-24	cAMP responsive element binding protein 1	Mus musculus	160-164
11773448-2	2002	In many cases transcriptional induction by cAMP is mediated through the interaction of a cAMP response-element binding protein (CREB) family member with a consensus cAMP response element (CRE; 5"-TGACGTCA-3") found in the promoter of target genes.	Cyclic AMP	43-47	cAMP responsive element binding protein 1	Mus musculus	128-132
11773448-2	2002	In many cases transcriptional induction by cAMP is mediated through the interaction of a cAMP response-element binding protein (CREB) family member with a consensus cAMP response element (CRE; 5"-TGACGTCA-3") found in the promoter of target genes.	Cyclic AMP	89-93	cAMP responsive element binding protein 1	Mus musculus	128-132
11773448-2	2002	In many cases transcriptional induction by cAMP is mediated through the interaction of a cAMP response-element binding protein (CREB) family member with a consensus cAMP response element (CRE; 5"-TGACGTCA-3") found in the promoter of target genes.	Cyclic AMP	89-93	cAMP responsive element binding protein 1	Mus musculus	128-132
11978843-1	2002	The cAMP cascade, including the cAMP response element-binding protein (CREB), is known to play an important role in neuronal survival and plasticity.	Cyclic AMP	4-8	cAMP responsive element binding protein 1	Mus musculus	32-69
11865068-1	2002	Activating transcription factor 1 (ATF1), CREB, and the cyclic AMP (cAMP) response element modulatory protein (CREM), which constitute a subfamily of the basic leucine zipper transcription factors, activate gene expression by binding as homo- or heterodimers to the cAMP response element in regulatory regions of target genes.	Cyclic AMP	266-270	cAMP responsive element binding protein 1	Mus musculus	42-46
11908639-11	2002	Whether the effect of methoxychlor requires the AP1/CREB binding element has yet to be established; however, the present finding provides an alternative signaling pathway for the xenoestrogens.	Methoxychlor	22-34	cAMP responsive element binding protein 1	Mus musculus	52-56
15018806-0	2002	In vivo CREB phosphorylation mediated by dopamine and NMDA receptor activation in mouse hippocampus and caudate nucleus.	Dopamine	41-49	cAMP responsive element binding protein 1	Mus musculus	8-12
15018806-3	2002	Ten minutes after C57BL/6 J mice were injected with either the dopamine D1 receptor agonist SKF-38393 hydrobromide or NMDA, immunoreactivity of phosphorylated CREB (pCREB) was significantly increased in all parts of the caudate nucleus but not in hippocampal regions.	SKF 38393 hydrobromide	92-114	cAMP responsive element binding protein 1	Mus musculus	159-163
15018806-5	2002	Except for the D1 receptor antagonist SCH-23390, which induced CREB phosphorylation in the caudate nucleus, dopamine and NMDA receptor antagonists had little effect on pCREB levels by themselves.	SCH 23390	38-47	cAMP responsive element binding protein 1	Mus musculus	63-67
11717377-9	2001	We demonstrate that the aversive properties of morphine are still present in CREB mutant mice despite a reduction of physical withdrawal.	Morphine	47-55	cAMP responsive element binding protein 1	Mus musculus	77-81
11717377-11	2001	In contrast, CREB mutant mice demonstrate an enhanced response to the reinforcing properties of cocaine compared with their wild-type controls in both conditioned place preference and sensitization behaviors.	Cocaine	96-103	cAMP responsive element binding protein 1	Mus musculus	13-17
11717354-0	2001	Phosphorylation of cAMP response element-binding protein in hippocampal neurons as a protective response after exposure to glutamate in vitro and ischemia in vivo.	Glutamic Acid	123-132	cAMP responsive element binding protein 1	Mus musculus	19-56
11717354-3	2001	Our results suggest that CREB phosphorylation in neurons after ischemia and exposure to glutamate is induced by NMDA receptor-gated calcium influx and subsequent activation of CaMK II-IV and that CREB phosphorylation after metabolic stress might show a neuroprotective response through CRE-mediated gene induction.	Glutamic Acid	88-97	cAMP responsive element binding protein 1	Mus musculus	25-29
11689682-1	2001	The cyclic AMP (cAMP)-responsive factor CREB induces target gene expression via constitutive (Q2) and inducible (KID, for kinase-inducible domain) activation domains that function synergistically in response to cellular signals.	Cyclic AMP	4-14	cAMP responsive element binding protein 1	Mus musculus	40-44
11717354-3	2001	Our results suggest that CREB phosphorylation in neurons after ischemia and exposure to glutamate is induced by NMDA receptor-gated calcium influx and subsequent activation of CaMK II-IV and that CREB phosphorylation after metabolic stress might show a neuroprotective response through CRE-mediated gene induction.	Glutamic Acid	88-97	cAMP responsive element binding protein 1	Mus musculus	196-200
11717354-3	2001	Our results suggest that CREB phosphorylation in neurons after ischemia and exposure to glutamate is induced by NMDA receptor-gated calcium influx and subsequent activation of CaMK II-IV and that CREB phosphorylation after metabolic stress might show a neuroprotective response through CRE-mediated gene induction.	Calcium	132-139	cAMP responsive element binding protein 1	Mus musculus	25-29
11689682-1	2001	The cyclic AMP (cAMP)-responsive factor CREB induces target gene expression via constitutive (Q2) and inducible (KID, for kinase-inducible domain) activation domains that function synergistically in response to cellular signals.	Cyclic AMP	16-20	cAMP responsive element binding protein 1	Mus musculus	40-44
11689682-3	2001	Here we investigate the mechanism underlying cooperativity between the Q2 domain and KID in CREB by in vitro transcription assay with naked DNA and chromatin templates containing the cAMP-responsive somatostatin promoter.	Cyclic AMP	183-187	cAMP responsive element binding protein 1	Mus musculus	92-96
11689682-7	2001	Correspondingly, overexpression of hTAFII130 potentiated CREB activity in cells exposed to cAMP, but had no effect on reporter gene expression in unstimulated cells.	Cyclic AMP	91-95	cAMP responsive element binding protein 1	Mus musculus	57-61
11557984-3	2001	Here we show that mice carrying a targeted disruption of the cyclic AMP (cAMP) response element binding (CREB) protein gene, or overexpressing a dominant-negative CREB inhibitor, exhibit fasting hypoglycaemia [corrected] and reduced expression of gluconeogenic enzymes.	Cyclic AMP	61-71	cAMP responsive element binding protein 1	Mus musculus	105-109
12235796-9	2001	Hypothesizing that nuclear proteins interacting with expanded polyglutamine stretches are involved in the pathogenesis, we found that that expanded polyglutamine stretches preferentially bind to TAF130, a cofactor involved in CREB-dependent transcriptional activation, and strongly suppressed CREB-dependent transcriptional activation.	polyglutamine	62-75	cAMP responsive element binding protein 1	Mus musculus	226-230
12235796-9	2001	Hypothesizing that nuclear proteins interacting with expanded polyglutamine stretches are involved in the pathogenesis, we found that that expanded polyglutamine stretches preferentially bind to TAF130, a cofactor involved in CREB-dependent transcriptional activation, and strongly suppressed CREB-dependent transcriptional activation.	polyglutamine	62-75	cAMP responsive element binding protein 1	Mus musculus	293-297
12235796-9	2001	Hypothesizing that nuclear proteins interacting with expanded polyglutamine stretches are involved in the pathogenesis, we found that that expanded polyglutamine stretches preferentially bind to TAF130, a cofactor involved in CREB-dependent transcriptional activation, and strongly suppressed CREB-dependent transcriptional activation.	polyglutamine	148-161	cAMP responsive element binding protein 1	Mus musculus	226-230
12235796-9	2001	Hypothesizing that nuclear proteins interacting with expanded polyglutamine stretches are involved in the pathogenesis, we found that that expanded polyglutamine stretches preferentially bind to TAF130, a cofactor involved in CREB-dependent transcriptional activation, and strongly suppressed CREB-dependent transcriptional activation.	polyglutamine	148-161	cAMP responsive element binding protein 1	Mus musculus	293-297
12235796-10	2001	Taken together, these findings suggest that the interference of CREB-dependent transcription by expanded polyglutamine stretches is involved in the neuronal dysfunction in polyglutamine diseases.	polyglutamine	105-118	cAMP responsive element binding protein 1	Mus musculus	64-68
11746356-9	2001	Stimulation of B104 and Mes42 cells with GDNF, but not with NTN, for 10 min resulted in CREB phosphorylation.	mes42	24-29	cAMP responsive element binding protein 1	Mus musculus	88-92
11707519-7	2001	Within 30-60 seconds following depolarization, phosphorylation of both the kinases and CREB was evident and could be inhibited by 2-aminoethoxydiphenyl borate.	2-aminoethoxydiphenyl borate	130-158	cAMP responsive element binding protein 1	Mus musculus	87-91
11549750-3	2001	Rats treated with HSV-mCREB in place conditioning studies spent more time in environments associated with cocaine, indicating increased cocaine reward.	Cocaine	106-113	cAMP responsive element binding protein 1	Mus musculus	22-27
11549750-9	2001	Moreover, the kappa opioid receptor antagonist nor-Binaltorphimine decreased immobility in HSV-CREB- and HSV-mCREB-treated rats, suggesting that CREB-mediated induction of dynorphin (an endogenous kappa receptor ligand) contributes to immobility behavior in the FST.	norbinaltorphimine	47-66	cAMP responsive element binding protein 1	Mus musculus	109-114
11557984-3	2001	Here we show that mice carrying a targeted disruption of the cyclic AMP (cAMP) response element binding (CREB) protein gene, or overexpressing a dominant-negative CREB inhibitor, exhibit fasting hypoglycaemia [corrected] and reduced expression of gluconeogenic enzymes.	Cyclic AMP	73-77	cAMP responsive element binding protein 1	Mus musculus	105-109
11579146-5	2001	Mutation of the CRE in chimeric constructs containing 3.6 kb of the 5" flanking sequence of the mouse TH gene or coexpression of a dominant-negative mutant of CREB prevented the stimulation of TH promoter activity by forskolin.	Colforsin	217-226	cAMP responsive element binding protein 1	Mus musculus	159-163
11447268-0	2001	Prostaglandins are required for CREB activation and cellular proliferation during liver regeneration.	Prostaglandins	0-14	cAMP responsive element binding protein 1	Mus musculus	32-36
11466226-5	2001	A gel-mobility shift assay using a probe containing the cAMP response element showed the presence of two specific protein-DNA complexes that contain one or more members of the cAMP responsive element-binding (CREB) protein family.	Cyclic AMP	56-60	cAMP responsive element binding protein 1	Mus musculus	176-207
11466226-5	2001	A gel-mobility shift assay using a probe containing the cAMP response element showed the presence of two specific protein-DNA complexes that contain one or more members of the cAMP responsive element-binding (CREB) protein family.	Cyclic AMP	56-60	cAMP responsive element binding protein 1	Mus musculus	209-213
11466227-4	2001	The optimal activation of the mouse transferrin promoter (mTf) by FSH requires the synergistic actions of the cAMP response element-binding protein (CREB) binding to the cAMP response element-like proximal region II (PRII) and the basic helix-loop-helix (bHLH) binding to the E-box.	Cyclic AMP	110-114	cAMP responsive element binding protein 1	Mus musculus	149-153
11447268-7	2001	In contrast, indocin treatment prevents the activation of CREB by phosphorylation that occurs during hepatic regeneration.	Indomethacin	13-20	cAMP responsive element binding protein 1	Mus musculus	58-62
11447268-8	2001	These data indicate that prostaglandin signaling is required during liver regeneration, that COX-2 plays a particularly important role but COX-1 is also involved, and implicate the activation of CREB rather than STAT3 as the mediator of prostaglandin signaling during liver regeneration.	Prostaglandins	237-250	cAMP responsive element binding protein 1	Mus musculus	195-199
11642609-4	2001	Previously we demonstrated that quenching of CREB activity in metastatic melanoma cells by means of a dominant-negative form of CREB (KCREB) led to a decrease in their tumorigenicity and metastatic potential in nude mice.	kcreb	134-139	cAMP responsive element binding protein 1	Mus musculus	45-49
11416141-3	2001	Cyclic AMP (cAMP)-responsive element (CRE)-binding protein (CREB) was present in one major CBE complex of Ba/F3 and TF-1 cells, and both in vitro-translated and Escherichia coli-synthesized CREB bound to CBE.	Cyclic AMP	0-10	cAMP responsive element binding protein 1	Mus musculus	60-64
11416141-3	2001	Cyclic AMP (cAMP)-responsive element (CRE)-binding protein (CREB) was present in one major CBE complex of Ba/F3 and TF-1 cells, and both in vitro-translated and Escherichia coli-synthesized CREB bound to CBE.	Cyclic AMP	12-16	cAMP responsive element binding protein 1	Mus musculus	60-64
11416141-5	2001	Stimulation of Ba/F3 cells with interleukin-3 (IL-3) promptly induced phosphorylation of CREB at serine(133) partially via a PKA-dependent pathway.	Serine	97-103	cAMP responsive element binding protein 1	Mus musculus	89-93
11241017-4	2001	RESULTS: CREB(A133) mice displayed significantly lower values of LV fiber shortening velocities over a wide range of afterloads, and they displayed smaller dobutamine-induced shifts from baseline contractility relations.	Dobutamine	156-166	cAMP responsive element binding protein 1	Mus musculus	9-18
11642609-4	2001	Previously we demonstrated that quenching of CREB activity in metastatic melanoma cells by means of a dominant-negative form of CREB (KCREB) led to a decrease in their tumorigenicity and metastatic potential in nude mice.	kcreb	134-139	cAMP responsive element binding protein 1	Mus musculus	128-132
11121103-0	2001	CREB is involved in mouse annexin A1 regulation by cAMP and glucocorticoids.	Cyclic AMP	51-55	cAMP responsive element binding protein 1	Mus musculus	0-4
11173928-6	2001	Consistent with these results, DPAT and forskolin increased phosphorylation of the cAMP response element binding protein (CREB), which was also blocked by Rp-cAMPS.	dpat	31-35	cAMP responsive element binding protein 1	Mus musculus	83-120
11173928-6	2001	Consistent with these results, DPAT and forskolin increased phosphorylation of the cAMP response element binding protein (CREB), which was also blocked by Rp-cAMPS.	dpat	31-35	cAMP responsive element binding protein 1	Mus musculus	122-126
11173928-6	2001	Consistent with these results, DPAT and forskolin increased phosphorylation of the cAMP response element binding protein (CREB), which was also blocked by Rp-cAMPS.	Colforsin	40-49	cAMP responsive element binding protein 1	Mus musculus	83-120
11173928-6	2001	Consistent with these results, DPAT and forskolin increased phosphorylation of the cAMP response element binding protein (CREB), which was also blocked by Rp-cAMPS.	Colforsin	40-49	cAMP responsive element binding protein 1	Mus musculus	122-126
11354513-2	2000	cAMP relays its signals via the transcription factors (TF) such as cAMP response element (CRE) binding protein (CREB), CRE modulator (CREM) and activator transcription factor-1 (ATF-1) to CRE-containing genes.	Cyclic AMP	0-4	cAMP responsive element binding protein 1	Mus musculus	112-116
11145992-0	2001	Galanin receptor 1 gene expression is regulated by cyclic AMP through a CREB-dependent mechanism.	Cyclic AMP	51-61	cAMP responsive element binding protein 1	Mus musculus	72-76
11145992-8	2001	Gel shift and super-shift experiments demonstrate that the transcription factor CREB can bind to both sites and is likely to be responsible for the cAMP-mediated increase in GalR1 promoter activity.	Cyclic AMP	148-152	cAMP responsive element binding protein 1	Mus musculus	80-84
11354513-12	2000	These results show that the cAMP signaling pathway is functional in the palate and that SAD alters CREB phosphorylation and inhibits its binding to CRE.	Cyclic AMP	28-32	cAMP responsive element binding protein 1	Mus musculus	99-103
11038257-1	2000	Possible direct effects of methamphetamine (METH) on transcription factors AP-1 and cAMP response element-binding protein (CREB) in the nucleus were assessed by electrophoretic mobility-shift assay.	Methamphetamine	27-42	cAMP responsive element binding protein 1	Mus musculus	84-121
11038257-1	2000	Possible direct effects of methamphetamine (METH) on transcription factors AP-1 and cAMP response element-binding protein (CREB) in the nucleus were assessed by electrophoretic mobility-shift assay.	Methamphetamine	27-42	cAMP responsive element binding protein 1	Mus musculus	123-127
11038257-1	2000	Possible direct effects of methamphetamine (METH) on transcription factors AP-1 and cAMP response element-binding protein (CREB) in the nucleus were assessed by electrophoretic mobility-shift assay.	Methamphetamine	44-48	cAMP responsive element binding protein 1	Mus musculus	84-121
11038257-1	2000	Possible direct effects of methamphetamine (METH) on transcription factors AP-1 and cAMP response element-binding protein (CREB) in the nucleus were assessed by electrophoretic mobility-shift assay.	Methamphetamine	44-48	cAMP responsive element binding protein 1	Mus musculus	123-127
11038257-3	2000	In addition, injections of METH to mice induced increases in the binding of AP-1 and CREB, which were depleted by preincubating the nuclear extract with anti-METH antibody.	Methamphetamine	27-31	cAMP responsive element binding protein 1	Mus musculus	85-89
11038257-3	2000	In addition, injections of METH to mice induced increases in the binding of AP-1 and CREB, which were depleted by preincubating the nuclear extract with anti-METH antibody.	Methamphetamine	158-162	cAMP responsive element binding protein 1	Mus musculus	85-89
11108134-8	2000	To verify gene induction by cAMP in association with protection we established activation of cAMP response element binding protein (CREB) by gel-shift analysis and moreover, treated macrophages with oligonucleotides containing a cAMP-responsive element (CRE) in order to scavenge CREB.	Cyclic AMP	28-32	cAMP responsive element binding protein 1	Mus musculus	93-130
11108134-8	2000	To verify gene induction by cAMP in association with protection we established activation of cAMP response element binding protein (CREB) by gel-shift analysis and moreover, treated macrophages with oligonucleotides containing a cAMP-responsive element (CRE) in order to scavenge CREB.	Cyclic AMP	28-32	cAMP responsive element binding protein 1	Mus musculus	132-136
11108134-8	2000	To verify gene induction by cAMP in association with protection we established activation of cAMP response element binding protein (CREB) by gel-shift analysis and moreover, treated macrophages with oligonucleotides containing a cAMP-responsive element (CRE) in order to scavenge CREB.	Cyclic AMP	28-32	cAMP responsive element binding protein 1	Mus musculus	280-284
11108134-8	2000	To verify gene induction by cAMP in association with protection we established activation of cAMP response element binding protein (CREB) by gel-shift analysis and moreover, treated macrophages with oligonucleotides containing a cAMP-responsive element (CRE) in order to scavenge CREB.	Oligonucleotides	199-215	cAMP responsive element binding protein 1	Mus musculus	280-284
11108134-8	2000	To verify gene induction by cAMP in association with protection we established activation of cAMP response element binding protein (CREB) by gel-shift analysis and moreover, treated macrophages with oligonucleotides containing a cAMP-responsive element (CRE) in order to scavenge CREB.	Cyclic AMP	93-97	cAMP responsive element binding protein 1	Mus musculus	132-136
10748032-5	2000	We report here that the TGF-beta-induced transcription from this promoter requires DNA binding of cAMP-response element-binding protein (CREB) to the nearby ATF/cAMP-response element site and of Smads to a nearby Smad binding sequence.	Cyclic AMP	98-102	cAMP responsive element binding protein 1	Mus musculus	137-141
11079454-2	2000	The CREB and CREM transcription factors are activated by phosphorylation of a key serine residue by kinase stimulated by cyclic AMP, calcium, growth factors and stress signals.	Serine	82-88	cAMP responsive element binding protein 1	Mus musculus	4-8
11079454-2	2000	The CREB and CREM transcription factors are activated by phosphorylation of a key serine residue by kinase stimulated by cyclic AMP, calcium, growth factors and stress signals.	Cyclic AMP	121-131	cAMP responsive element binding protein 1	Mus musculus	4-8
11079454-2	2000	The CREB and CREM transcription factors are activated by phosphorylation of a key serine residue by kinase stimulated by cyclic AMP, calcium, growth factors and stress signals.	Calcium	133-140	cAMP responsive element binding protein 1	Mus musculus	4-8
11018520-3	2000	TPA and EGF induced the phosphorylation of cyclic AMP-responsive element binding protein (CREB) at Ser-133 and ATF1 at Ser-63 in wild type cells and this was abolished by inhibition of the mitogen-activated protein kinase cascade.	Tetradecanoylphorbol Acetate	0-3	cAMP responsive element binding protein 1	Mus musculus	43-88
11018520-3	2000	TPA and EGF induced the phosphorylation of cyclic AMP-responsive element binding protein (CREB) at Ser-133 and ATF1 at Ser-63 in wild type cells and this was abolished by inhibition of the mitogen-activated protein kinase cascade.	Tetradecanoylphorbol Acetate	0-3	cAMP responsive element binding protein 1	Mus musculus	90-94
11018520-3	2000	TPA and EGF induced the phosphorylation of cyclic AMP-responsive element binding protein (CREB) at Ser-133 and ATF1 at Ser-63 in wild type cells and this was abolished by inhibition of the mitogen-activated protein kinase cascade.	Serine	99-102	cAMP responsive element binding protein 1	Mus musculus	43-88
11018520-3	2000	TPA and EGF induced the phosphorylation of cyclic AMP-responsive element binding protein (CREB) at Ser-133 and ATF1 at Ser-63 in wild type cells and this was abolished by inhibition of the mitogen-activated protein kinase cascade.	Serine	99-102	cAMP responsive element binding protein 1	Mus musculus	90-94
11018520-3	2000	TPA and EGF induced the phosphorylation of cyclic AMP-responsive element binding protein (CREB) at Ser-133 and ATF1 at Ser-63 in wild type cells and this was abolished by inhibition of the mitogen-activated protein kinase cascade.	Serine	119-122	cAMP responsive element binding protein 1	Mus musculus	43-88
11018520-3	2000	TPA and EGF induced the phosphorylation of cyclic AMP-responsive element binding protein (CREB) at Ser-133 and ATF1 at Ser-63 in wild type cells and this was abolished by inhibition of the mitogen-activated protein kinase cascade.	Serine	119-122	cAMP responsive element binding protein 1	Mus musculus	90-94
11018520-4	2000	In contrast, the TPA- and EGF-induced phosphorylation of CREB/ATF1 was barely detectable in MSK1-/- cells.	Tetradecanoylphorbol Acetate	17-20	cAMP responsive element binding protein 1	Mus musculus	57-61
10976922-0	2000	A dominant negative CREB (cAMP response element-binding protein) isoform inhibits thyrocyte growth, thyroid-specific gene expression, differentiation, and function.	Cyclic AMP	26-30	cAMP responsive element binding protein 1	Mus musculus	20-24
10943725-0	2000	Blockade of cyclic AMP-responsive element DNA binding in the brain of CREB delta/alpha mutant mice.	Cyclic AMP	12-22	cAMP responsive element binding protein 1	Mus musculus	70-74
10936515-3	2000	Since the promoter in IL-1beta gene contains binding motifs for NF-kappaB/Rel, AP-1, NF-IL6, and CREB/ATF, which appear to be important in LPS-mediated IL-1beta induction, the effects of DEX on the activation of these transcription factors were examined.	Dexamethasone	187-190	cAMP responsive element binding protein 1	Mus musculus	97-101
10936515-4	2000	Treatment of DEX to RAW 264.7 cells induced a dose-related inhibition of NF-kappaB/Rel and AP-1 in chloramphenicol acetyltransferase activity, while neither NF-IL6 nor CREB/ATF activation was affected by DEX.	Dexamethasone	13-16	cAMP responsive element binding protein 1	Mus musculus	168-172
10884023-3	2000	As detected by immunohistochemistry in SCN slices from wild-type mice, melatonin completely blocked PACAP-stimulated CREB phosphorylation at low concentrations (1 nM).	Melatonin	71-80	cAMP responsive element binding protein 1	Mus musculus	117-121
10884023-4	2000	In Mel1a melatonin receptor-deficient mice, the PACAP-induced CREB phosphorylation was inhibited only at melatonin concentrations of 100 nM.	Melatonin	9-18	cAMP responsive element binding protein 1	Mus musculus	62-66
11354513-2	2000	cAMP relays its signals via the transcription factors (TF) such as cAMP response element (CRE) binding protein (CREB), CRE modulator (CREM) and activator transcription factor-1 (ATF-1) to CRE-containing genes.	Cyclic AMP	67-71	cAMP responsive element binding protein 1	Mus musculus	112-116
10764409-6	2000	Ryanodine, which inhibits RyRs, increased P-CREB staining and c-fos levels.	Ryanodine	0-9	cAMP responsive element binding protein 1	Mus musculus	44-48
10764409-7	2000	Forskolin, an activator of adenylyl cyclase, and sodium nitroprusside, an NO donor, increased P-CREB and c-fos levels.	Colforsin	0-9	cAMP responsive element binding protein 1	Mus musculus	96-100
10764409-7	2000	Forskolin, an activator of adenylyl cyclase, and sodium nitroprusside, an NO donor, increased P-CREB and c-fos levels.	Nitroprusside	49-69	cAMP responsive element binding protein 1	Mus musculus	96-100
10764409-8	2000	Nisoldipine, an inhibitor of VDCCs, reversed the effects of depolarization and ryanodine on P-CREB and c-fos levels, but not the effects of forskolin or sodium nitroprusside.	Nisoldipine	0-11	cAMP responsive element binding protein 1	Mus musculus	94-98
10764409-8	2000	Nisoldipine, an inhibitor of VDCCs, reversed the effects of depolarization and ryanodine on P-CREB and c-fos levels, but not the effects of forskolin or sodium nitroprusside.	Ryanodine	79-88	cAMP responsive element binding protein 1	Mus musculus	94-98
10679065-1	2000	The cAMP response element (CRE) binding protein (CREB) is emerging as a key regulatory factor of gene transcription in B lymphocytes; however, the postreceptor pathways that regulate CREB activity and CRE-dependent gene transcription remain largely undefined.	Cyclic AMP	4-8	cAMP responsive element binding protein 1	Mus musculus	49-53
10679065-1	2000	The cAMP response element (CRE) binding protein (CREB) is emerging as a key regulatory factor of gene transcription in B lymphocytes; however, the postreceptor pathways that regulate CREB activity and CRE-dependent gene transcription remain largely undefined.	Cyclic AMP	4-8	cAMP responsive element binding protein 1	Mus musculus	183-187
10629058-6	2000	Here we demonstrate that the transcription factor, CREB, is constitutively expressed in preadipocytes and throughout the differentiation process and that CREB is stimulated by conventional differentiation-inducing agents such as insulin, dexamethasone, and dibutyryl cAMP.	Dexamethasone	238-251	cAMP responsive element binding protein 1	Mus musculus	51-55
10679065-4	2000	Phosphorylation of CREB on serine 133, a modification that positively regulates its trans-activation, was concomitantly increased.	Serine	27-33	cAMP responsive element binding protein 1	Mus musculus	19-23
10679065-5	2000	Inhibition of p38 MAPK by pretreating CH31 B cells with the highly specific bicyclic imidazole inhibitor, SB203580, reduced BCR-induced CREB phosphorylation.	imidazole	85-94	cAMP responsive element binding protein 1	Mus musculus	136-140
10679065-5	2000	Inhibition of p38 MAPK by pretreating CH31 B cells with the highly specific bicyclic imidazole inhibitor, SB203580, reduced BCR-induced CREB phosphorylation.	SB 203580	106-114	cAMP responsive element binding protein 1	Mus musculus	136-140
10679065-6	2000	BCR cross-linking also led to increased MAPK-activated protein kinase-2 activity, an enzyme that lies immediately downstream from p38 MAPK; MAPK-activated protein kinase-2 immune complexes phosphorylated a peptide substrate containing the CREB serine 133 phosphoacceptor motif.	Serine	244-250	cAMP responsive element binding protein 1	Mus musculus	239-243
10708700-1	2000	A growing body of evidence supports an important role of the transcription factor cAMP responsive element binding protein (CREB) in mediating opioid-induced changes in the cAMP pathway.	Cyclic AMP	82-86	cAMP responsive element binding protein 1	Mus musculus	123-127
10708700-3	2000	The effect of morphine on the level of the transcription factor CREB, as well as CREB phosphorylation, was investigated in NG108-15 cells.	Morphine	14-22	cAMP responsive element binding protein 1	Mus musculus	64-68
10708700-4	2000	Morphine and the delta-opioid receptor agonist [D-Pen(2,5)]enkephalin (DPDPE) produced a dose-dependent increase in CREB phosphorylation.	Morphine	0-8	cAMP responsive element binding protein 1	Mus musculus	116-120
10708700-4	2000	Morphine and the delta-opioid receptor agonist [D-Pen(2,5)]enkephalin (DPDPE) produced a dose-dependent increase in CREB phosphorylation.	d-pen(2,5)]enkephalin	48-69	cAMP responsive element binding protein 1	Mus musculus	116-120
10708700-4	2000	Morphine and the delta-opioid receptor agonist [D-Pen(2,5)]enkephalin (DPDPE) produced a dose-dependent increase in CREB phosphorylation.	Enkephalin, D-Penicillamine (2,5)-	71-76	cAMP responsive element binding protein 1	Mus musculus	116-120
10629058-6	2000	Here we demonstrate that the transcription factor, CREB, is constitutively expressed in preadipocytes and throughout the differentiation process and that CREB is stimulated by conventional differentiation-inducing agents such as insulin, dexamethasone, and dibutyryl cAMP.	Dexamethasone	238-251	cAMP responsive element binding protein 1	Mus musculus	154-158
10629058-6	2000	Here we demonstrate that the transcription factor, CREB, is constitutively expressed in preadipocytes and throughout the differentiation process and that CREB is stimulated by conventional differentiation-inducing agents such as insulin, dexamethasone, and dibutyryl cAMP.	Cyclic AMP	267-271	cAMP responsive element binding protein 1	Mus musculus	51-55
10629058-6	2000	Here we demonstrate that the transcription factor, CREB, is constitutively expressed in preadipocytes and throughout the differentiation process and that CREB is stimulated by conventional differentiation-inducing agents such as insulin, dexamethasone, and dibutyryl cAMP.	Cyclic AMP	267-271	cAMP responsive element binding protein 1	Mus musculus	154-158
10629058-8	2000	Inducible expression of VP16-CREB alone was sufficient to initiate adipogenesis as determined by triacylglycerol storage, cell morphology, and the expression of two adipocyte marker genes, peroxisome proliferator activated receptor gamma 2, and fatty acid binding protein.	Triglycerides	97-112	cAMP responsive element binding protein 1	Mus musculus	24-33
10629058-8	2000	Inducible expression of VP16-CREB alone was sufficient to initiate adipogenesis as determined by triacylglycerol storage, cell morphology, and the expression of two adipocyte marker genes, peroxisome proliferator activated receptor gamma 2, and fatty acid binding protein.	Fatty Acids	245-255	cAMP responsive element binding protein 1	Mus musculus	24-33
10575022-0	1999	Nitric oxide signaling contributes to late-phase LTP and CREB phosphorylation in the hippocampus.	Nitric Oxide	0-12	cAMP responsive element binding protein 1	Mus musculus	57-61
10965152-6	2000	This switch in isoform composition just precedes the change in the extent of phosphorylation at serines 214 and 409, and occurs at a time when PKA phosphorylation of CREB is increasing.	Serine	96-103	cAMP responsive element binding protein 1	Mus musculus	166-170
10706216-9	2000	Furthermore, long-term, but not short-term social memory is dependent on protein synthesis and cyclic AMP responsive element binding protein (CREB) function.	Cyclic AMP	95-105	cAMP responsive element binding protein 1	Mus musculus	142-146
10066798-9	1999	pp60(v-src) induction of CREB was blocked by the p38 inhibitor SB203580 or by mutation of CREB at Ser133.	SB 203580	63-71	cAMP responsive element binding protein 1	Mus musculus	25-29
10406459-0	1999	A dominant role for the Raf-MEK pathway in forskolin, 12-O-tetradecanoyl-phorbol acetate, and platelet-derived growth factor-induced CREB (cAMP-responsive element-binding protein) activation, uncoupled from serine 133 phosphorylation in NIH 3T3 cells.	Tetradecanoylphorbol Acetate	54-88	cAMP responsive element binding protein 1	Mus musculus	133-137
10406459-0	1999	A dominant role for the Raf-MEK pathway in forskolin, 12-O-tetradecanoyl-phorbol acetate, and platelet-derived growth factor-induced CREB (cAMP-responsive element-binding protein) activation, uncoupled from serine 133 phosphorylation in NIH 3T3 cells.	Serine	207-213	cAMP responsive element binding protein 1	Mus musculus	133-137
10406459-1	1999	In this study we describe that platelet-derived growth factor (PDGF), 12-O-tetradecanoyl-phorbol-acetate (TPA), and forskolin induced CREB (cAMP-responsive element-binding protein) Ser-133 phosphorylation with comparable magnitude and kinetics in NIH 3T3 cells.	Tetradecanoylphorbol Acetate	70-104	cAMP responsive element binding protein 1	Mus musculus	134-138
10406459-1	1999	In this study we describe that platelet-derived growth factor (PDGF), 12-O-tetradecanoyl-phorbol-acetate (TPA), and forskolin induced CREB (cAMP-responsive element-binding protein) Ser-133 phosphorylation with comparable magnitude and kinetics in NIH 3T3 cells.	Tetradecanoylphorbol Acetate	70-104	cAMP responsive element binding protein 1	Mus musculus	140-179
10406459-1	1999	In this study we describe that platelet-derived growth factor (PDGF), 12-O-tetradecanoyl-phorbol-acetate (TPA), and forskolin induced CREB (cAMP-responsive element-binding protein) Ser-133 phosphorylation with comparable magnitude and kinetics in NIH 3T3 cells.	Tetradecanoylphorbol Acetate	106-109	cAMP responsive element binding protein 1	Mus musculus	134-138
10406459-1	1999	In this study we describe that platelet-derived growth factor (PDGF), 12-O-tetradecanoyl-phorbol-acetate (TPA), and forskolin induced CREB (cAMP-responsive element-binding protein) Ser-133 phosphorylation with comparable magnitude and kinetics in NIH 3T3 cells.	Tetradecanoylphorbol Acetate	106-109	cAMP responsive element binding protein 1	Mus musculus	140-179
10406459-1	1999	In this study we describe that platelet-derived growth factor (PDGF), 12-O-tetradecanoyl-phorbol-acetate (TPA), and forskolin induced CREB (cAMP-responsive element-binding protein) Ser-133 phosphorylation with comparable magnitude and kinetics in NIH 3T3 cells.	Colforsin	116-125	cAMP responsive element binding protein 1	Mus musculus	134-138
10406459-1	1999	In this study we describe that platelet-derived growth factor (PDGF), 12-O-tetradecanoyl-phorbol-acetate (TPA), and forskolin induced CREB (cAMP-responsive element-binding protein) Ser-133 phosphorylation with comparable magnitude and kinetics in NIH 3T3 cells.	Colforsin	116-125	cAMP responsive element binding protein 1	Mus musculus	140-179
10406459-1	1999	In this study we describe that platelet-derived growth factor (PDGF), 12-O-tetradecanoyl-phorbol-acetate (TPA), and forskolin induced CREB (cAMP-responsive element-binding protein) Ser-133 phosphorylation with comparable magnitude and kinetics in NIH 3T3 cells.	Serine	181-184	cAMP responsive element binding protein 1	Mus musculus	134-138
10406459-1	1999	In this study we describe that platelet-derived growth factor (PDGF), 12-O-tetradecanoyl-phorbol-acetate (TPA), and forskolin induced CREB (cAMP-responsive element-binding protein) Ser-133 phosphorylation with comparable magnitude and kinetics in NIH 3T3 cells.	Serine	181-184	cAMP responsive element binding protein 1	Mus musculus	140-179
10406459-2	1999	While forskolin was the most potent activator of CREB, TPA or PDGF modestly increased CREB activity.	Colforsin	6-15	cAMP responsive element binding protein 1	Mus musculus	49-53
10406459-2	1999	While forskolin was the most potent activator of CREB, TPA or PDGF modestly increased CREB activity.	Colforsin	6-15	cAMP responsive element binding protein 1	Mus musculus	86-90
10406459-2	1999	While forskolin was the most potent activator of CREB, TPA or PDGF modestly increased CREB activity.	Tetradecanoylphorbol Acetate	55-58	cAMP responsive element binding protein 1	Mus musculus	86-90
10406459-3	1999	The role of protein kinase C, protein kinase A, and the Raf-MEK kinase pathway in the activation and Ser-133 phosphorylation of CREB by these three stimuli was investigated.	Serine	101-104	cAMP responsive element binding protein 1	Mus musculus	128-132
10406459-6	1999	We further demonstrate that although inhibition of Raf-MEK represses forskolin-induced CREB activation, forskolin by itself failed to activate ERK1/2 and Elk-1 mediated transcription.	Colforsin	69-78	cAMP responsive element binding protein 1	Mus musculus	87-91
10406459-7	1999	These results suggest that a basal level of Raf-MEK activity is necessary for both PDGF- and forskolin-induced CREB activation, independent of CREB Ser-133 phosphorylation.	Colforsin	93-102	cAMP responsive element binding protein 1	Mus musculus	111-115
10330034-4	1999	Although hyperoxic exposure produced activation of both nuclear factor-kappaB and CREB in lung cell populations, only CREB activation was reduced in the mice treated with lisofylline.	lisofylline	171-182	cAMP responsive element binding protein 1	Mus musculus	82-86
10330034-4	1999	Although hyperoxic exposure produced activation of both nuclear factor-kappaB and CREB in lung cell populations, only CREB activation was reduced in the mice treated with lisofylline.	lisofylline	171-182	cAMP responsive element binding protein 1	Mus musculus	118-122
10330034-6	1999	These results suggest that lisofylline ameliorates hyperoxia-induced lung injury and mortality through inhibiting CREB activation, membrane oxidation, and proinflammatory cytokine expression in the lungs.	lisofylline	27-38	cAMP responsive element binding protein 1	Mus musculus	114-118
10480911-8	1999	cAMP-response element-binding protein (CREB) phosphorylation by Calpha is also increased in ethanol-treated cells.	Ethanol	92-99	cAMP responsive element binding protein 1	Mus musculus	0-37
10480911-8	1999	cAMP-response element-binding protein (CREB) phosphorylation by Calpha is also increased in ethanol-treated cells.	Ethanol	92-99	cAMP responsive element binding protein 1	Mus musculus	39-43
10480911-10	1999	These results suggest that ethanol affects a cascade of events allowing for sustained nuclear localization of Calpha and prolonged CREB phosphorylation.	Ethanol	27-34	cAMP responsive element binding protein 1	Mus musculus	131-135
10507546-3	1999	Western blots demonstrate a 1.9-fold increase in cyclic AMP response element binding protein (CREB) and a 2.4-fold increase phospho-CREB immunoreactivities in spinal cord homogenates from morphine tolerant animals.	Morphine	188-196	cAMP responsive element binding protein 1	Mus musculus	132-136
10406470-1	1999	Although Ca2+ and cAMP mediate their effects through distinct pathways, both signals converge upon the phosphorylation of the cAMP response element (CRE) binding protein, CREB, thereby activating transcription of CRE-regulated genes.	Cyclic AMP	18-22	cAMP responsive element binding protein 1	Mus musculus	171-175
10406470-1	1999	Although Ca2+ and cAMP mediate their effects through distinct pathways, both signals converge upon the phosphorylation of the cAMP response element (CRE) binding protein, CREB, thereby activating transcription of CRE-regulated genes.	Cyclic AMP	126-130	cAMP responsive element binding protein 1	Mus musculus	171-175
10397175-7	1999	Although the c-AMP-response element binding protein (CREB) could be the common target of both calcium-dependent and -independent dephosphorylation, our results do not support the involvement of CREB in the regulation of c-myb gene expression.	Calcium	94-101	cAMP responsive element binding protein 1	Mus musculus	13-51
10397175-7	1999	Although the c-AMP-response element binding protein (CREB) could be the common target of both calcium-dependent and -independent dephosphorylation, our results do not support the involvement of CREB in the regulation of c-myb gene expression.	Calcium	94-101	cAMP responsive element binding protein 1	Mus musculus	53-57
12110939-6	1999	3) In contrast the activation of cAMP/PKA mediated a significant inhibiton of the phosphorylation of ERK1/2 JNK and p38 MAPK and ATF-2 but it enhanced the phosphorylation of CREB.	Cyclic AMP	33-37	cAMP responsive element binding protein 1	Mus musculus	174-178
9990041-7	1999	ATF-2 is present in nuclear extracts from chondrogenic cell lines and binds, as a complex with a CRE-binding protein (CREB)/CRE modulator protein, to the cAMP response element (CRE) in the cyclin D1 promoter.	Cyclic AMP	154-158	cAMP responsive element binding protein 1	Mus musculus	118-122
9680121-3	1998	In the present study, the promoter of UL4 was examined and found to contain a cAMP-response element which bound the transcription factor CREB, and was strongly activated by cAMP.	Cyclic AMP	78-82	cAMP responsive element binding protein 1	Mus musculus	137-141
9748539-3	1998	Phosphorylated-CREB (P-CREB) immunoreactivity in response to the dopamine D1 agonist (+/-)SKF 38393 (15 mg/kg, i.p.)	Dopamine	65-73	cAMP responsive element binding protein 1	Mus musculus	15-19
9748539-3	1998	Phosphorylated-CREB (P-CREB) immunoreactivity in response to the dopamine D1 agonist (+/-)SKF 38393 (15 mg/kg, i.p.)	Dopamine	65-73	cAMP responsive element binding protein 1	Mus musculus	23-27
9727976-2	1998	The mouse pituitary cell line AtT20 was used to show that the CBP recruitment step (CREB phosphorylation on serine-133) can be uncoupled from CREB/CBP-activated transcription.	Serine	108-114	cAMP responsive element binding protein 1	Mus musculus	84-88
9773357-4	1998	Studies in vivo and in cultured cells indicate that the induction of BDNF and TrkB is mediated by the cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB), a transcription factor that is activated by cAMP and Ca2+ intracellular pathways.	Cyclic AMP	102-132	cAMP responsive element binding protein 1	Mus musculus	174-178
9852576-0	1998	CREB in the mouse SCN: a molecular interface coding the phase-adjusting stimuli light, glutamate, PACAP, and melatonin for clockwork access.	Glutamic Acid	87-96	cAMP responsive element binding protein 1	Mus musculus	0-4
9852576-0	1998	CREB in the mouse SCN: a molecular interface coding the phase-adjusting stimuli light, glutamate, PACAP, and melatonin for clockwork access.	Melatonin	109-118	cAMP responsive element binding protein 1	Mus musculus	0-4
9852576-5	1998	We analyzed immunocytochemically the inducible phosphorylation of the transcription factor Ca2+/cAMP response element-binding protein (CREB) in the SCN of a melatonin-proficient (C3H) and a melatonin-deficient (C57BL) mouse strain.	Melatonin	157-166	cAMP responsive element binding protein 1	Mus musculus	91-133
9852576-5	1998	We analyzed immunocytochemically the inducible phosphorylation of the transcription factor Ca2+/cAMP response element-binding protein (CREB) in the SCN of a melatonin-proficient (C3H) and a melatonin-deficient (C57BL) mouse strain.	Melatonin	157-166	cAMP responsive element binding protein 1	Mus musculus	135-139
9852576-5	1998	We analyzed immunocytochemically the inducible phosphorylation of the transcription factor Ca2+/cAMP response element-binding protein (CREB) in the SCN of a melatonin-proficient (C3H) and a melatonin-deficient (C57BL) mouse strain.	Melatonin	190-199	cAMP responsive element binding protein 1	Mus musculus	91-133
9852576-5	1998	We analyzed immunocytochemically the inducible phosphorylation of the transcription factor Ca2+/cAMP response element-binding protein (CREB) in the SCN of a melatonin-proficient (C3H) and a melatonin-deficient (C57BL) mouse strain.	Melatonin	190-199	cAMP responsive element binding protein 1	Mus musculus	135-139
9852576-8	1998	In vitro, PACAP and glutamate induced CREB phosphorylation in the SCN of both mouse strains, with PACAP being more effective during late subjective daytime and glutamate being more effective during subjective nighttime.	Glutamic Acid	20-29	cAMP responsive element binding protein 1	Mus musculus	38-42
9852576-8	1998	In vitro, PACAP and glutamate induced CREB phosphorylation in the SCN of both mouse strains, with PACAP being more effective during late subjective daytime and glutamate being more effective during subjective nighttime.	Glutamic Acid	160-169	cAMP responsive element binding protein 1	Mus musculus	38-42
9852576-9	1998	Melatonin suppressed PACAP- but not glutamate-induced phosphorylation of CREB.	Melatonin	0-9	cAMP responsive element binding protein 1	Mus musculus	73-77
9852576-10	1998	The distinct temporal domains during which glutamate and PACAP induce CREB phosphorylation imply that during the light/dark transition the SCN switches sensitivity between these two RHT transmitters.	Glutamic Acid	43-52	cAMP responsive element binding protein 1	Mus musculus	70-74
9798910-1	1998	Previous studies have shown that activation of the cyclic AMP (cAMP) pathway down-regulates CREB expression in CATH.a cells, an effect that appears to be mediated via inhibition of CREB gene transcription.	Cyclic AMP	51-61	cAMP responsive element binding protein 1	Mus musculus	92-96
9798910-1	1998	Previous studies have shown that activation of the cyclic AMP (cAMP) pathway down-regulates CREB expression in CATH.a cells, an effect that appears to be mediated via inhibition of CREB gene transcription.	Cyclic AMP	51-61	cAMP responsive element binding protein 1	Mus musculus	181-185
9798910-1	1998	Previous studies have shown that activation of the cyclic AMP (cAMP) pathway down-regulates CREB expression in CATH.a cells, an effect that appears to be mediated via inhibition of CREB gene transcription.	Cyclic AMP	63-67	cAMP responsive element binding protein 1	Mus musculus	92-96
9798910-1	1998	Previous studies have shown that activation of the cyclic AMP (cAMP) pathway down-regulates CREB expression in CATH.a cells, an effect that appears to be mediated via inhibition of CREB gene transcription.	Cyclic AMP	63-67	cAMP responsive element binding protein 1	Mus musculus	181-185
9798910-3	1998	In contrast to the findings in CATH.a cells, activation of the cAMP pathway up-regulates CREB expression in C6 glioma cells.	Cyclic AMP	63-67	cAMP responsive element binding protein 1	Mus musculus	89-93
9798910-12	1998	These findings demonstrate cell type-specific effects of the cAMP pathway on CREB expression, which appear to be mediated via differential regulation of the CREB promoter.	Cyclic AMP	61-65	cAMP responsive element binding protein 1	Mus musculus	77-81
9798910-12	1998	These findings demonstrate cell type-specific effects of the cAMP pathway on CREB expression, which appear to be mediated via differential regulation of the CREB promoter.	Cyclic AMP	61-65	cAMP responsive element binding protein 1	Mus musculus	157-161
9755049-6	1998	Because forskolin and calyculin A increase in vivo phosphorylation of cAMP binding response element (CREB), the inability of milrinone, genistein, CPX, and NS004 to increase CREB phosphorylation suggests that they do not stimulate protein kinase A or inhibit phosphatase activity.	Colforsin	8-17	cAMP responsive element binding protein 1	Mus musculus	101-105
9755049-6	1998	Because forskolin and calyculin A increase in vivo phosphorylation of cAMP binding response element (CREB), the inability of milrinone, genistein, CPX, and NS004 to increase CREB phosphorylation suggests that they do not stimulate protein kinase A or inhibit phosphatase activity.	Cyclic AMP	70-74	cAMP responsive element binding protein 1	Mus musculus	101-105
9773357-4	1998	Studies in vivo and in cultured cells indicate that the induction of BDNF and TrkB is mediated by the cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB), a transcription factor that is activated by cAMP and Ca2+ intracellular pathways.	Cyclic AMP	134-138	cAMP responsive element binding protein 1	Mus musculus	174-178
9773357-4	1998	Studies in vivo and in cultured cells indicate that the induction of BDNF and TrkB is mediated by the cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB), a transcription factor that is activated by cAMP and Ca2+ intracellular pathways.	Cyclic AMP	225-229	cAMP responsive element binding protein 1	Mus musculus	174-178
9539763-1	1998	CREB, the cAMP response element binding protein, is a key transcriptional regulator of a large number of genes containing a CRE consensus sequence in their upstream regulatory regions.	Cyclic AMP	10-14	cAMP responsive element binding protein 1	Mus musculus	0-4
9605932-0	1998	Transcriptional activation of the macrophage migration-inhibitory factor gene by the corticotropin-releasing factor is mediated by the cyclic adenosine 3",5"- monophosphate responsive element-binding protein CREB in pituitary cells.	Cyclic AMP	135-172	cAMP responsive element binding protein 1	Mus musculus	208-212
9575798-4	1998	Here, we investigate the circadian regulation of CREB and Ser-133-phospho-CREB (PCREB) in the mouse esophagus by immunocytochemical and biochemical methods.	Serine	58-61	cAMP responsive element binding protein 1	Mus musculus	74-78
9596555-2	1998	Binding of radiolabeled oligonucleotide probes for the "leucine-zipper" transcription factors, including activator protein-1 (AP1) and cyclic AMP response element binding protein (CREB), was markedly reduced in nuclear extracts of the adrenals from mice sacrificed 2 h after the subcutaneous injection of triamcinolone acetonide (TA), an agonist at glucocorticoid (GC) receptors which are also a transcription factor with "zinc-finger" motifs.	Oligonucleotides	24-39	cAMP responsive element binding protein 1	Mus musculus	135-178
9523559-9	1998	At the same time, they show that desensitization of cyclic AMP signaling not only fails to hamper, but actually amplifies PACAP-stimulated CREB-regulated transcription.	Cyclic AMP	52-62	cAMP responsive element binding protein 1	Mus musculus	139-143
9596555-2	1998	Binding of radiolabeled oligonucleotide probes for the "leucine-zipper" transcription factors, including activator protein-1 (AP1) and cyclic AMP response element binding protein (CREB), was markedly reduced in nuclear extracts of the adrenals from mice sacrificed 2 h after the subcutaneous injection of triamcinolone acetonide (TA), an agonist at glucocorticoid (GC) receptors which are also a transcription factor with "zinc-finger" motifs.	Triamcinolone Acetonide	330-332	cAMP responsive element binding protein 1	Mus musculus	180-184
11081181-8	1998	Further, expression of a dominant inhibitory mutant of CREB reduced cAMP stimulated transcription of the full length POMC promoter and the PTRE.	Cyclic AMP	68-72	cAMP responsive element binding protein 1	Mus musculus	55-59
9685213-0	1998	Cyclic AMP potentiates growth hormone-dependent differentiation of 3T3-F442A preadipocytes: possible involvement of the transcription factor CREB.	Cyclic AMP	0-10	cAMP responsive element binding protein 1	Mus musculus	141-145
9685213-6	1998	We analysed the stimulatory effects of cyclic AMP during GH priming and found that cyclic AMP induced phosphorylation of the cyclic AMP response element (CRE) binding protein CREB and activated transcription of a CRE-linked reporter gene.	Cyclic AMP	39-49	cAMP responsive element binding protein 1	Mus musculus	175-179
9685213-6	1998	We analysed the stimulatory effects of cyclic AMP during GH priming and found that cyclic AMP induced phosphorylation of the cyclic AMP response element (CRE) binding protein CREB and activated transcription of a CRE-linked reporter gene.	Cyclic AMP	83-93	cAMP responsive element binding protein 1	Mus musculus	175-179
9685213-6	1998	We analysed the stimulatory effects of cyclic AMP during GH priming and found that cyclic AMP induced phosphorylation of the cyclic AMP response element (CRE) binding protein CREB and activated transcription of a CRE-linked reporter gene.	Cyclic AMP	83-93	cAMP responsive element binding protein 1	Mus musculus	175-179
9685213-7	1998	Furthermore, GH also stimulated CREB phosphorylation and activation and this effect was potentiated by cyclic AMP.	Cyclic AMP	103-113	cAMP responsive element binding protein 1	Mus musculus	32-36
9538221-1	1998	The cAMP-responsive element (CRE) binding protein/activating transcription factor (CREB/ATF) family plays a major role in the expression of skeletal-specific genes and skeletal tissue development.	Cyclic AMP	4-8	cAMP responsive element binding protein 1	Mus musculus	83-87
9488481-3	1998	ZIP kinase physically binds to ATF4, a member of the activating transcription factor/cyclic AMP-responsive element-binding protein (ATF/CREB) family, through interaction between their leucine zippers.	Cyclic AMP	85-95	cAMP responsive element binding protein 1	Mus musculus	136-140
9601608-3	1998	Increases in nuclear calcium activate gene transcription by a mechanism that is distinct from gene regulation by cytoplasmic calcium signals and involves the cAMP response element (CRE) and the CRE binding protein, CREB.	Calcium	21-28	cAMP responsive element binding protein 1	Mus musculus	215-219
9601608-3	1998	Increases in nuclear calcium activate gene transcription by a mechanism that is distinct from gene regulation by cytoplasmic calcium signals and involves the cAMP response element (CRE) and the CRE binding protein, CREB.	Calcium	125-132	cAMP responsive element binding protein 1	Mus musculus	215-219
9601608-3	1998	Increases in nuclear calcium activate gene transcription by a mechanism that is distinct from gene regulation by cytoplasmic calcium signals and involves the cAMP response element (CRE) and the CRE binding protein, CREB.	Cyclic AMP	158-162	cAMP responsive element binding protein 1	Mus musculus	215-219
9596555-2	1998	Binding of radiolabeled oligonucleotide probes for the "leucine-zipper" transcription factors, including activator protein-1 (AP1) and cyclic AMP response element binding protein (CREB), was markedly reduced in nuclear extracts of the adrenals from mice sacrificed 2 h after the subcutaneous injection of triamcinolone acetonide (TA), an agonist at glucocorticoid (GC) receptors which are also a transcription factor with "zinc-finger" motifs.	Oligonucleotides	24-39	cAMP responsive element binding protein 1	Mus musculus	180-184
9596555-2	1998	Binding of radiolabeled oligonucleotide probes for the "leucine-zipper" transcription factors, including activator protein-1 (AP1) and cyclic AMP response element binding protein (CREB), was markedly reduced in nuclear extracts of the adrenals from mice sacrificed 2 h after the subcutaneous injection of triamcinolone acetonide (TA), an agonist at glucocorticoid (GC) receptors which are also a transcription factor with "zinc-finger" motifs.	Triamcinolone Acetonide	305-328	cAMP responsive element binding protein 1	Mus musculus	180-184
9280057-5	1997	Thus, while phosphorylation of cAMP response element binding protein (CREB) by the cAMP-dependent protein kinase A is the prerequisite for induction, it has been proposed that the following attenuation involves both CREB dephosphorylation and repression by the inducible repressor ICER.	Cyclic AMP	31-35	cAMP responsive element binding protein 1	Mus musculus	70-74
9597751-0	1998	Coupling gene expression to cAMP signalling: role of CREB and CREM.	Cyclic AMP	28-32	cAMP responsive element binding protein 1	Mus musculus	53-57
9597751-6	1998	Direct activation of gene expression by CREB requires phosphorylation by the cAMP-dependent PKA to serine 133.	Cyclic AMP	77-81	cAMP responsive element binding protein 1	Mus musculus	40-44
9597751-6	1998	Direct activation of gene expression by CREB requires phosphorylation by the cAMP-dependent PKA to serine 133.	Serine	99-105	cAMP responsive element binding protein 1	Mus musculus	40-44
9460650-3	1997	In the present study we have investigated the expression of the cAMP response-element binding protein (CREB) in mouse pituitary, and its regulation during a pharmacological paradigm that simulates activation of the CRF-ACTH axis.	Cyclic AMP	64-68	cAMP responsive element binding protein 1	Mus musculus	103-107
9460650-5	1997	Following treatment with the 11 beta-hydroxylase inhibitor metyrapone, CRE binding activity was increased at 1 and 2 h but levels of CREB protein were not found to be consistently elevated.	Metyrapone	59-69	cAMP responsive element binding protein 1	Mus musculus	133-137
9460650-6	1997	However, using a Ser133 phosphopeptide-specific antibody, that detects the functionally important phosphorylated form of CREB (P-CREB), we have shown that levels of pituitary P-CREB are markedly elevated following metyrapone.	Metyrapone	214-224	cAMP responsive element binding protein 1	Mus musculus	121-125
9460650-6	1997	However, using a Ser133 phosphopeptide-specific antibody, that detects the functionally important phosphorylated form of CREB (P-CREB), we have shown that levels of pituitary P-CREB are markedly elevated following metyrapone.	Metyrapone	214-224	cAMP responsive element binding protein 1	Mus musculus	127-133
9460650-6	1997	However, using a Ser133 phosphopeptide-specific antibody, that detects the functionally important phosphorylated form of CREB (P-CREB), we have shown that levels of pituitary P-CREB are markedly elevated following metyrapone.	Metyrapone	214-224	cAMP responsive element binding protein 1	Mus musculus	175-181
9366390-6	1997	Okadaic acid increased CREB1 phosphorylation at Ser133 and junB transcriptional activation, suggesting the action of protein phosphatase-1 (PP-1) or -2A (PP-2A).	Okadaic Acid	0-12	cAMP responsive element binding protein 1	Mus musculus	23-28
9295372-5	1997	Levels of the transcription factor cAMP-responsive element binding protein (CREB), phosphorylated at Ser-133, increased rapidly in response to brief action potential stimulation but remained at high levels several minutes after an action potential burst.	Serine	101-104	cAMP responsive element binding protein 1	Mus musculus	35-74
9295372-5	1997	Levels of the transcription factor cAMP-responsive element binding protein (CREB), phosphorylated at Ser-133, increased rapidly in response to brief action potential stimulation but remained at high levels several minutes after an action potential burst.	Serine	101-104	cAMP responsive element binding protein 1	Mus musculus	76-80
9280057-5	1997	Thus, while phosphorylation of cAMP response element binding protein (CREB) by the cAMP-dependent protein kinase A is the prerequisite for induction, it has been proposed that the following attenuation involves both CREB dephosphorylation and repression by the inducible repressor ICER.	Cyclic AMP	31-35	cAMP responsive element binding protein 1	Mus musculus	216-220
7740167-5	1995	In several cell types tested, elevated cAMP leads to the phosphorylation and activation of the transcription factor CREB by protein kinase A (Gonzalez and Montminy, 1989; Sheng et al., 1991), and one target gene for CREB action is the pituitary-specific transcription factor Pit-1 or GHF-1 (step 4) (Bodner et al., 1988; Ingraham et al., 1988; McCormick et al., 1990).	Cyclic AMP	39-43	cAMP responsive element binding protein 1	Mus musculus	216-220
9140073-8	1997	Following treatment with forskolin, thapsigargin, or dexamethasone, the CRE binding protein (CREB) was phosphorylated at levels correlating with the level of induced gene expression.	Colforsin	25-34	cAMP responsive element binding protein 1	Mus musculus	72-91
9140073-8	1997	Following treatment with forskolin, thapsigargin, or dexamethasone, the CRE binding protein (CREB) was phosphorylated at levels correlating with the level of induced gene expression.	Colforsin	25-34	cAMP responsive element binding protein 1	Mus musculus	93-97
9140073-8	1997	Following treatment with forskolin, thapsigargin, or dexamethasone, the CRE binding protein (CREB) was phosphorylated at levels correlating with the level of induced gene expression.	Thapsigargin	36-48	cAMP responsive element binding protein 1	Mus musculus	72-91
9140073-8	1997	Following treatment with forskolin, thapsigargin, or dexamethasone, the CRE binding protein (CREB) was phosphorylated at levels correlating with the level of induced gene expression.	Thapsigargin	36-48	cAMP responsive element binding protein 1	Mus musculus	93-97
9140073-8	1997	Following treatment with forskolin, thapsigargin, or dexamethasone, the CRE binding protein (CREB) was phosphorylated at levels correlating with the level of induced gene expression.	Dexamethasone	53-66	cAMP responsive element binding protein 1	Mus musculus	72-91
9140073-8	1997	Following treatment with forskolin, thapsigargin, or dexamethasone, the CRE binding protein (CREB) was phosphorylated at levels correlating with the level of induced gene expression.	Dexamethasone	53-66	cAMP responsive element binding protein 1	Mus musculus	93-97
9549403-3	1997	Following its phosphorylation by protein kinase A, CREB binds to the enhancer element CRE which is located in the upstream region of cAMP-responsive genes, thus triggering transcription.	Cyclic AMP	133-137	cAMP responsive element binding protein 1	Mus musculus	51-55
9549403-5	1997	In aplysia, CREB activation has been interfered with by microinjection of CRE containing oligonucleotides into cultured neurons.	Oligonucleotides	89-105	cAMP responsive element binding protein 1	Mus musculus	12-16
8885292-1	1996	Nuclear extracts of mouse brain contained binding of radiolabeled oligonucleotide probes for particular transcription factors with leucine-zipper motifs including activator protein-1 (AP1), cyclic AMP response element binding protein (CREB) and c-Myc.	Oligonucleotides	66-81	cAMP responsive element binding protein 1	Mus musculus	190-233
8769368-2	1996	The kinetics of protein kinase (PK-A)-dependent cAMP response element binding protein (CREB) phosphorylation closely parallel the changes in transcription of cAMP-responsive genes by run-on assay.	Cyclic AMP	48-52	cAMP responsive element binding protein 1	Mus musculus	87-91
8648100-1	1996	Transcription factors of the cAMP-responsive element (CRE) binding protein/activating transcription factor (CREB/ATF) family were implicated in the expression of T cell-specific genes and in the expression of oncogenic retroviruses associated with leukemia in T and B lymphocytes.	Cyclic AMP	29-33	cAMP responsive element binding protein 1	Mus musculus	108-112
8648100-10	1996	Taken collectively, these results suggest that recruitment of CREB and ATF2 to the promoter of genes is tightly regulated during activation of T and B lymphocytes and implicate a cross-talk of cAMP and non-cAMP pathways in the regulation of transcriptional processes at late stages of activation in T and B lymphocytes stimulated via the Ag receptor.	Cyclic AMP	193-197	cAMP responsive element binding protein 1	Mus musculus	62-66
8648100-10	1996	Taken collectively, these results suggest that recruitment of CREB and ATF2 to the promoter of genes is tightly regulated during activation of T and B lymphocytes and implicate a cross-talk of cAMP and non-cAMP pathways in the regulation of transcriptional processes at late stages of activation in T and B lymphocytes stimulated via the Ag receptor.	Cyclic AMP	206-210	cAMP responsive element binding protein 1	Mus musculus	62-66
8595201-0	1995	Cocaine-induced CREB phosphorylation and c-Fos expression are suppressed in Parkinsonism model mice.	Cocaine	0-7	cAMP responsive element binding protein 1	Mus musculus	16-20
8595201-3	1995	In MPTP-treated mice, in which dopaminergic neurones are degenerated and which show Parkinsonism-like behaviour, however, CREB phosphorylation is not induced by cocaine exposure and c-fos expression is significantly depressed in comparison with controls.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	3-7	cAMP responsive element binding protein 1	Mus musculus	122-126
7622577-6	1995	Western blot analysis of extracts of staged palatal shelves with an antibody specific for phospho-ser 133-CREB demonstrated a steady increase in CREB phosphorylation at this residue during palate development.	Serine	98-101	cAMP responsive element binding protein 1	Mus musculus	106-110
7622577-6	1995	Western blot analysis of extracts of staged palatal shelves with an antibody specific for phospho-ser 133-CREB demonstrated a steady increase in CREB phosphorylation at this residue during palate development.	Serine	98-101	cAMP responsive element binding protein 1	Mus musculus	145-149
7552295-0	1995	Effects of kainic acid induced seizures on immediate early gene expression in mice with a targeted mutation of the CREB gene.	Kainic Acid	11-22	cAMP responsive element binding protein 1	Mus musculus	115-119
7763238-7	1995	The induction of CREB mRNA by dibutyryl cAMP suggests that the up-regulation of dystrophin mRNA expression might occur via transcriptional activation.	dibutyryl	30-39	cAMP responsive element binding protein 1	Mus musculus	17-21
7763238-7	1995	The induction of CREB mRNA by dibutyryl cAMP suggests that the up-regulation of dystrophin mRNA expression might occur via transcriptional activation.	Cyclic AMP	40-44	cAMP responsive element binding protein 1	Mus musculus	17-21
7721872-10	1995	Using DNA binding gel mobility shift assay we demonstrated that rapamycin potently inhibited the binding of CREB/ATF transcription factors to CRE elements in the murine proximal PCNA promoter.	Sirolimus	64-73	cAMP responsive element binding protein 1	Mus musculus	108-112
7721872-11	1995	These results suggest that PCNA is a preferred target in a rapamycin-sensitive transduction pathway, and that the mechanism by which rampamycin inhibits PCNA gene expression may involve the inhibition of the interaction of CREB/ATF transcription factors with CRE elements in the proximal PCNA promoter.	rampamycin	133-143	cAMP responsive element binding protein 1	Mus musculus	223-227
7835696-4	1995	One essential cis-regulatory element within the enhancer-like sequence is an activating transcription factor/cAMP response element (CRE)-binding protein (ATF/CREB)-binding site, although the promoter is not cAMP responsive.	Cyclic AMP	109-113	cAMP responsive element binding protein 1	Mus musculus	158-162
7835696-5	1995	Electrophoretic mobility shift assays and mutational analyses suggest that the promoter site is bound by nuclear protein complexes containing cAMP-independent members of the ATF/CREB family of proteins and c-Jun, and are functionally distinct from the AP1-related TPA-response element (TRE) binding activity.	Cyclic AMP	142-146	cAMP responsive element binding protein 1	Mus musculus	178-182
7835696-5	1995	Electrophoretic mobility shift assays and mutational analyses suggest that the promoter site is bound by nuclear protein complexes containing cAMP-independent members of the ATF/CREB family of proteins and c-Jun, and are functionally distinct from the AP1-related TPA-response element (TRE) binding activity.	Tetradecanoylphorbol Acetate	264-267	cAMP responsive element binding protein 1	Mus musculus	178-182
7740167-5	1995	In several cell types tested, elevated cAMP leads to the phosphorylation and activation of the transcription factor CREB by protein kinase A (Gonzalez and Montminy, 1989; Sheng et al., 1991), and one target gene for CREB action is the pituitary-specific transcription factor Pit-1 or GHF-1 (step 4) (Bodner et al., 1988; Ingraham et al., 1988; McCormick et al., 1990).	Cyclic AMP	39-43	cAMP responsive element binding protein 1	Mus musculus	116-120
9150427-4	1997	The motif represents a half-site for binding of the cAMP response element (CRE) binding protein (CREB).	Cyclic AMP	52-56	cAMP responsive element binding protein 1	Mus musculus	97-101
9056415-4	1997	We thus examined the effects of TGF-beta on activation of the cAMP regulatory element binding protein CREB, a nuclear transcription factor which mediates transcription of genes containing CRE recognition sequences in their promoters.	Cyclic AMP	62-66	cAMP responsive element binding protein 1	Mus musculus	102-106
9056415-5	1997	We examined the ability of TGF-beta-treated murine embryonic palate mesenchymal (MEPM) cells to phosphorylate CREB on the amino acid residue serine 133, phosphorylation of which is indispensable for transcriptional activation.	Serine	141-147	cAMP responsive element binding protein 1	Mus musculus	110-114
9056415-6	1997	TGF-beta treatment led to increased phosphorylation of CREB ser-133 in a time- and dose-dependent manner.	Serine	60-63	cAMP responsive element binding protein 1	Mus musculus	55-59
9056415-12	1997	Together, these data suggest an alternative or novel CREB kinase in MEPM cells through which TGF-beta acts to induce CREB ser-133 phosphorylation and subsequent activation of CRE-containing genes.	Serine	122-125	cAMP responsive element binding protein 1	Mus musculus	53-57
9056415-12	1997	Together, these data suggest an alternative or novel CREB kinase in MEPM cells through which TGF-beta acts to induce CREB ser-133 phosphorylation and subsequent activation of CRE-containing genes.	Serine	122-125	cAMP responsive element binding protein 1	Mus musculus	117-121
9032121-6	1997	Inhibition of xanthine oxidase by prior feeding with either an allopurinol-supplemented or a tungsten-enriched diet prevented hemorrhage-induced activation of CREB, but not NF-kappaB.	Allopurinol	63-74	cAMP responsive element binding protein 1	Mus musculus	159-163
9032121-6	1997	Inhibition of xanthine oxidase by prior feeding with either an allopurinol-supplemented or a tungsten-enriched diet prevented hemorrhage-induced activation of CREB, but not NF-kappaB.	Tungsten	93-101	cAMP responsive element binding protein 1	Mus musculus	159-163
8999994-1	1997	BACKGROUND: The cAMP responsive element binding protein (CREB) is a transcription factor the activity of which is modulated by increases in the intracellular levels of cAMP and calcium.	Cyclic AMP	16-20	cAMP responsive element binding protein 1	Mus musculus	57-61
8999994-1	1997	BACKGROUND: The cAMP responsive element binding protein (CREB) is a transcription factor the activity of which is modulated by increases in the intracellular levels of cAMP and calcium.	Calcium	177-184	cAMP responsive element binding protein 1	Mus musculus	16-55
8999994-1	1997	BACKGROUND: The cAMP responsive element binding protein (CREB) is a transcription factor the activity of which is modulated by increases in the intracellular levels of cAMP and calcium.	Calcium	177-184	cAMP responsive element binding protein 1	Mus musculus	57-61
9238850-6	1997	Direct activation of gene expression by CREB requires phosphorylation by the cAMP-dependent protein kinase A to the serine-133 residue.	Serine	116-122	cAMP responsive element binding protein 1	Mus musculus	40-44
8662559-0	1996	Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB.	Morphine	13-21	cAMP responsive element binding protein 1	Mus musculus	78-82
8683108-6	1996	Binding activity was competed with unlabeled oligonucleotides that contained the junB CRE-like site or the somatostatin CRE consensus motif, the latter observation suggests that members of the activating transcription factor/CRE binding protein (CREB) family may mediate mIg-dependent junB transcription.	Oligonucleotides	45-61	cAMP responsive element binding protein 1	Mus musculus	246-250
8683108-9	1996	CRE-like nucleoprotein complexes from Bal17 B cells contained constitutively bound CREB-1, which was phosphorylated on serine 133 in response to mIg cross-linking.	Serine	119-125	cAMP responsive element binding protein 1	Mus musculus	83-89
8620554-5	1996	The differential responsiveness of CREB to forskolin in PC12 cells and BAL-17 B cells may relate to the more marked elevation of cAMP in the former as opposed to the latter; however, high concentrations of dbcAMP which should readily enter B cells and artificially increase cAMP levels still failed to induce CREB Ser133 phosphorylation, even in conjunction with a phosphodiesterase inhibitor.	Colforsin	43-52	cAMP responsive element binding protein 1	Mus musculus	309-313
8627337-1	1996	We have recently demonstrated that mRNA expression of cyclic AMP (cAMP) response element-binding protein (CREB) is down-regulated in CATH.a cells (a neural-derived cell line) by activation of the cAMP pathway.	Cyclic AMP	54-64	cAMP responsive element binding protein 1	Mus musculus	106-110
8627337-1	1996	We have recently demonstrated that mRNA expression of cyclic AMP (cAMP) response element-binding protein (CREB) is down-regulated in CATH.a cells (a neural-derived cell line) by activation of the cAMP pathway.	Cyclic AMP	66-70	cAMP responsive element binding protein 1	Mus musculus	106-110
8627337-1	1996	We have recently demonstrated that mRNA expression of cyclic AMP (cAMP) response element-binding protein (CREB) is down-regulated in CATH.a cells (a neural-derived cell line) by activation of the cAMP pathway.	Cyclic AMP	196-200	cAMP responsive element binding protein 1	Mus musculus	106-110
8627337-3	1996	It was found that cycloheximide, a protein synthesis inhibitor, prevented the forskolin-induced decrease in CREB mRNA levels in CATH.a cells.	Cycloheximide	18-31	cAMP responsive element binding protein 1	Mus musculus	108-112
8627337-3	1996	It was found that cycloheximide, a protein synthesis inhibitor, prevented the forskolin-induced decrease in CREB mRNA levels in CATH.a cells.	Colforsin	78-87	cAMP responsive element binding protein 1	Mus musculus	108-112
8627337-4	1996	Nuclear run-on assays demonstrated that forskolin decreased the rate of CREB transcription by close to 50%.	Colforsin	40-49	cAMP responsive element binding protein 1	Mus musculus	72-76
8627337-5	1996	Moreover, forskolin decreased chloramphenicol acetyltransferase (CAT) activity in CATH.a cells transiently transfected with a construct containing 1,240 bp of CREB promoter fused to a CAT reporter plasmid.	Colforsin	10-19	cAMP responsive element binding protein 1	Mus musculus	159-163
8627337-6	1996	Possible mechanisms by which activation of the cAMP pathway leads to a decrease in CREB gene transcription are discussed.	Cyclic AMP	47-51	cAMP responsive element binding protein 1	Mus musculus	83-87
8605879-1	1996	To define the role of cAMP signaling in gene control, we have generated mice with a mutation in the cAMP response element binding protein (CREB) gene.	Cyclic AMP	22-26	cAMP responsive element binding protein 1	Mus musculus	100-137
8605879-1	1996	To define the role of cAMP signaling in gene control, we have generated mice with a mutation in the cAMP response element binding protein (CREB) gene.	Cyclic AMP	22-26	cAMP responsive element binding protein 1	Mus musculus	139-143
7476883-3	1995	To determine whether this withdrawal-induced increase in cAMP modifies gene expression, we studied phosphorylation of the cAMP response element-binding protein (CREB) and expression of the c-fos gene, known to contain a cAMP response element, in NG108-15 cells after abrupt withdrawal from chronic treatment with carbachol.	Cyclic AMP	122-126	cAMP responsive element binding protein 1	Mus musculus	161-165
7476883-4	1995	Prostaglandin E1, which activates adenylyl cyclase, caused concentration-dependent increases in the phosphorylation of CREB and in the abundance of c-fos mRNA.	Alprostadil	0-16	cAMP responsive element binding protein 1	Mus musculus	119-123
7476883-6	1995	In cells treated with carbachol for 48 hr, induction of withdrawal with the muscarinic antagonist atropine led to a small increase in intracellular cAMP concentration but an 11.6-fold increase in the phosphorylation of CREB and a 3.4-fold increase in accumulation of c-fos mRNA.	Carbachol	22-31	cAMP responsive element binding protein 1	Mus musculus	219-223
7476883-6	1995	In cells treated with carbachol for 48 hr, induction of withdrawal with the muscarinic antagonist atropine led to a small increase in intracellular cAMP concentration but an 11.6-fold increase in the phosphorylation of CREB and a 3.4-fold increase in accumulation of c-fos mRNA.	Atropine	98-106	cAMP responsive element binding protein 1	Mus musculus	219-223
7476883-7	1995	The adenylyl cyclase inhibitor 2",5"-dideoxyadenosine, which attenuated the chronic carbachol-induced increase in cAMP concentration, prevented the increased phosphorylation of CREB and the enhanced accumulation of c-fos mRNA during atropine-induced withdrawal.	2',5'-dideoxyadenosine	31-53	cAMP responsive element binding protein 1	Mus musculus	177-181
7476883-7	1995	The adenylyl cyclase inhibitor 2",5"-dideoxyadenosine, which attenuated the chronic carbachol-induced increase in cAMP concentration, prevented the increased phosphorylation of CREB and the enhanced accumulation of c-fos mRNA during atropine-induced withdrawal.	Carbachol	84-93	cAMP responsive element binding protein 1	Mus musculus	177-181
7615829-7	1995	In AtT20 cells, electrophoretic mobility shift assays and factor-specific antibody supershifts showed that an oligonucleotide containing the chromogranin A CRE site formed a single, homogeneous protein-DNA complex containing the CRE-binding protein CREB.	Oligonucleotides	110-125	cAMP responsive element binding protein 1	Mus musculus	249-253
8202542-6	1994	These data demonstrate that CREB is not the sole mediator of cAMP-dependent transcriptional regulation and probably acts in concert with a specific subset of cAMP response element-binding proteins to transduce the cAMP signal and, in its absence, these same proteins can compensate for CREB function in vivo.	Cyclic AMP	158-162	cAMP responsive element binding protein 1	Mus musculus	28-32
8035176-2	1994	An injection of saline transiently increased binding of both probes for activator protein 1 (AP1) and cyclic AMP response element binding protein (CREB) 30 min after the injection, and NMDA was effective in inducing a more potent increment of binding of both probes 1-5 h after the injection than did saline.	Sodium Chloride	16-22	cAMP responsive element binding protein 1	Mus musculus	102-145
8035176-2	1994	An injection of saline transiently increased binding of both probes for activator protein 1 (AP1) and cyclic AMP response element binding protein (CREB) 30 min after the injection, and NMDA was effective in inducing a more potent increment of binding of both probes 1-5 h after the injection than did saline.	Sodium Chloride	16-22	cAMP responsive element binding protein 1	Mus musculus	147-151
8035176-2	1994	An injection of saline transiently increased binding of both probes for activator protein 1 (AP1) and cyclic AMP response element binding protein (CREB) 30 min after the injection, and NMDA was effective in inducing a more potent increment of binding of both probes 1-5 h after the injection than did saline.	Sodium Chloride	301-307	cAMP responsive element binding protein 1	Mus musculus	102-145
8035176-2	1994	An injection of saline transiently increased binding of both probes for activator protein 1 (AP1) and cyclic AMP response element binding protein (CREB) 30 min after the injection, and NMDA was effective in inducing a more potent increment of binding of both probes 1-5 h after the injection than did saline.	Sodium Chloride	301-307	cAMP responsive element binding protein 1	Mus musculus	147-151
8035176-5	1994	These results support the proposal that an intracerebroventricular injection of NMDA may selectively potentiate DNA binding activities of both AP1 and CREB through activation of the NMDA receptor complex in mouse brain.	N-Methylaspartate	80-84	cAMP responsive element binding protein 1	Mus musculus	151-155
7516466-1	1994	We have examined the activity and phosphorylation state of the cyclic AMP (cAMP) response element binding factor (CREB) in intact NIH 3T3 cells following microinjection of expression plasmids encoding regulatory proteins of type 1 (PP1) and 2A (PP2A) serine/threonine-specific protein phosphatases.	Cyclic AMP	63-73	cAMP responsive element binding protein 1	Mus musculus	114-118
7516466-1	1994	We have examined the activity and phosphorylation state of the cyclic AMP (cAMP) response element binding factor (CREB) in intact NIH 3T3 cells following microinjection of expression plasmids encoding regulatory proteins of type 1 (PP1) and 2A (PP2A) serine/threonine-specific protein phosphatases.	Cyclic AMP	75-79	cAMP responsive element binding protein 1	Mus musculus	114-118
7516466-2	1994	Changes in CREB phosphorylation in the injected cells were monitored by indirect immunofluorescence using an affinity-purified antiserum (Ab5322) which specifically recognizes CREB phosphorylated at Ser-133, and changes in transcriptional activity of CREB were monitored by expression of a reporter gene regulated by cAMP.	Serine	199-202	cAMP responsive element binding protein 1	Mus musculus	176-180
7516466-2	1994	Changes in CREB phosphorylation in the injected cells were monitored by indirect immunofluorescence using an affinity-purified antiserum (Ab5322) which specifically recognizes CREB phosphorylated at Ser-133, and changes in transcriptional activity of CREB were monitored by expression of a reporter gene regulated by cAMP.	Serine	199-202	cAMP responsive element binding protein 1	Mus musculus	176-180
7516466-3	1994	cAMP-stimulated phosphorylation in NIH 3T3 cells is normally transient, and as expected, after stimulation of cells with cell-permeable cAMP analogs, the level of phosphorylated CREB was found to initially increase and then return to a basal level within 4 h. Microinjection of an expression vector encoding a constitutively active form of inhibitor 1 (I-1), a PP1-specific inhibitor, by itself resulted in an apparent increase in phosphorylated CREB in unstimulated cells.	Cyclic AMP	0-4	cAMP responsive element binding protein 1	Mus musculus	178-182
7516466-3	1994	cAMP-stimulated phosphorylation in NIH 3T3 cells is normally transient, and as expected, after stimulation of cells with cell-permeable cAMP analogs, the level of phosphorylated CREB was found to initially increase and then return to a basal level within 4 h. Microinjection of an expression vector encoding a constitutively active form of inhibitor 1 (I-1), a PP1-specific inhibitor, by itself resulted in an apparent increase in phosphorylated CREB in unstimulated cells.	Cyclic AMP	0-4	cAMP responsive element binding protein 1	Mus musculus	446-450
7516466-3	1994	cAMP-stimulated phosphorylation in NIH 3T3 cells is normally transient, and as expected, after stimulation of cells with cell-permeable cAMP analogs, the level of phosphorylated CREB was found to initially increase and then return to a basal level within 4 h. Microinjection of an expression vector encoding a constitutively active form of inhibitor 1 (I-1), a PP1-specific inhibitor, by itself resulted in an apparent increase in phosphorylated CREB in unstimulated cells.	Cyclic AMP	136-140	cAMP responsive element binding protein 1	Mus musculus	178-182
7516466-3	1994	cAMP-stimulated phosphorylation in NIH 3T3 cells is normally transient, and as expected, after stimulation of cells with cell-permeable cAMP analogs, the level of phosphorylated CREB was found to initially increase and then return to a basal level within 4 h. Microinjection of an expression vector encoding a constitutively active form of inhibitor 1 (I-1), a PP1-specific inhibitor, by itself resulted in an apparent increase in phosphorylated CREB in unstimulated cells.	Cyclic AMP	136-140	cAMP responsive element binding protein 1	Mus musculus	446-450
7516466-4	1994	Moreover, injection of the I-1 vector resulted in the prolonged appearance of phosphorylated CREB in cells after cAMP stimulation.	Cyclic AMP	113-117	cAMP responsive element binding protein 1	Mus musculus	93-97
7516466-7	1994	These results provide further evidence for a role of a PP1 as the primary protein (Ser/Thr) phosphatase regulating the dephosphorylation of Ser-133 and thereby limiting the transcriptional activity of CREB.	Serine	83-86	cAMP responsive element binding protein 1	Mus musculus	201-205
7528210-1	1994	Activating transcription factor-1 (ATF1) and cAMP response element binding protein (CREB) have been implicated in cAMP-, calcium-, and virus-induced transcriptional alterations.	Cyclic AMP	45-49	cAMP responsive element binding protein 1	Mus musculus	84-88
7528210-1	1994	Activating transcription factor-1 (ATF1) and cAMP response element binding protein (CREB) have been implicated in cAMP-, calcium-, and virus-induced transcriptional alterations.	Calcium	121-128	cAMP responsive element binding protein 1	Mus musculus	45-82
7528210-1	1994	Activating transcription factor-1 (ATF1) and cAMP response element binding protein (CREB) have been implicated in cAMP-, calcium-, and virus-induced transcriptional alterations.	Calcium	121-128	cAMP responsive element binding protein 1	Mus musculus	84-88
7975930-2	1994	An injection of NMDA increased binding of both probes for activator protein 1 (AP1) and cyclic AMP response element binding protein (CREB) 1 to 5 h after the injection compared with that of saline, in a dose-dependent manner at doses from 0.05 to 0.4 micrograms.	N-Methylaspartate	16-20	cAMP responsive element binding protein 1	Mus musculus	88-131
7975930-2	1994	An injection of NMDA increased binding of both probes for activator protein 1 (AP1) and cyclic AMP response element binding protein (CREB) 1 to 5 h after the injection compared with that of saline, in a dose-dependent manner at doses from 0.05 to 0.4 micrograms.	N-Methylaspartate	16-20	cAMP responsive element binding protein 1	Mus musculus	133-137
7975930-7	1994	These results support the proposal that an intracerebroventricular injection of NMDA may selectively potentiate DNA binding activities of both AP1 and CREB through in vivo activation of the NMDA receptor complex in the murine brain.	N-Methylaspartate	80-84	cAMP responsive element binding protein 1	Mus musculus	151-155
8202542-6	1994	These data demonstrate that CREB is not the sole mediator of cAMP-dependent transcriptional regulation and probably acts in concert with a specific subset of cAMP response element-binding proteins to transduce the cAMP signal and, in its absence, these same proteins can compensate for CREB function in vivo.	Cyclic AMP	158-162	cAMP responsive element binding protein 1	Mus musculus	286-290
8202542-6	1994	These data demonstrate that CREB is not the sole mediator of cAMP-dependent transcriptional regulation and probably acts in concert with a specific subset of cAMP response element-binding proteins to transduce the cAMP signal and, in its absence, these same proteins can compensate for CREB function in vivo.	Cyclic AMP	158-162	cAMP responsive element binding protein 1	Mus musculus	28-32
8202542-6	1994	These data demonstrate that CREB is not the sole mediator of cAMP-dependent transcriptional regulation and probably acts in concert with a specific subset of cAMP response element-binding proteins to transduce the cAMP signal and, in its absence, these same proteins can compensate for CREB function in vivo.	Cyclic AMP	158-162	cAMP responsive element binding protein 1	Mus musculus	286-290
33974233-5	2021	RNA sequencing of phenotypically-isolated HSCs indicated that the molecular responses to dmPGE2 are similar in young and old, including CREB1 activation and increased cell survival and homeostasis.	16,16-Dimethylprostaglandin E2	89-95	cAMP responsive element binding protein 1	Mus musculus	136-141
8031468-3	1994	Western blot analysis revealed differential expression of some AP-1 (c-jun, jun-B, and jun-D) and ATF (43- and 47-kDa cyclic AMP-responsive element binding protein (CREB) family members) in the different subclones; while c-jun expression was noted in the subclones with the greater malignant potential, jun-D was expressed in those with the lesser malignant potential.	Cyclic AMP	118-128	cAMP responsive element binding protein 1	Mus musculus	165-169
8170480-8	1994	In contrast, CREB formed specific complexes with both the proenkephalin enhancer and a cAMP- and calcium-regulated element (CaRE) within the c-fos gene.	Cyclic AMP	87-91	cAMP responsive element binding protein 1	Mus musculus	13-17
8170480-8	1994	In contrast, CREB formed specific complexes with both the proenkephalin enhancer and a cAMP- and calcium-regulated element (CaRE) within the c-fos gene.	Calcium	97-104	cAMP responsive element binding protein 1	Mus musculus	13-17
8170480-9	1994	Moreover, we found that hypertonic saline induced CREB phosphorylation in cells that express the transgene within the paraventricular nucleus and supraoptic nucleus.	Sodium Chloride	35-41	cAMP responsive element binding protein 1	Mus musculus	50-54
7912684-9	1994	To assess the role of CREB in the in vivo transduction of cAMP signalling, mice deficient in CREB protein have been generated by homologous recombination in embryonic stem (ES) cells.	Cyclic AMP	58-62	cAMP responsive element binding protein 1	Mus musculus	22-26
7912684-11	1994	The cAMP-dependent LacZ transgenic mice in a CREB mutant genetic background also show perinatal activation of the reporter gene.	Cyclic AMP	4-8	cAMP responsive element binding protein 1	Mus musculus	45-49
2140898-4	1990	In NIH 3T3 cells stably expressing CREB, c-jun is no longer induced by serum, but this repression can be relieved by treatment of the cells with forskolin, an agonist of the adenylate cyclase pathway.	Colforsin	145-154	cAMP responsive element binding protein 1	Mus musculus	35-39
33794254-10	2021	HU210 enhanced amitriptyline-stimulated CREB phosphorylation and protection against TNF-alpha-induced apoptosis, whereas JWH133 had no effect.	HU 211	0-5	cAMP responsive element binding protein 1	Mus musculus	40-44
33794254-10	2021	HU210 enhanced amitriptyline-stimulated CREB phosphorylation and protection against TNF-alpha-induced apoptosis, whereas JWH133 had no effect.	Amitriptyline	15-28	cAMP responsive element binding protein 1	Mus musculus	40-44
8119898-2	1994	A mutation in the cAMP response element (CRE) (-87 to -74), which binds CCATT/enhancer-binding protein beta (C/EBP beta) and/or cAMP response element-binding protein (CREB), resulted in a 4- and 20-fold elevation in the level of bGH mRNA in the liver and kidney of transgenic mice, respectively.	Cyclic AMP	18-22	cAMP responsive element binding protein 1	Mus musculus	128-165
8119898-2	1994	A mutation in the cAMP response element (CRE) (-87 to -74), which binds CCATT/enhancer-binding protein beta (C/EBP beta) and/or cAMP response element-binding protein (CREB), resulted in a 4- and 20-fold elevation in the level of bGH mRNA in the liver and kidney of transgenic mice, respectively.	Cyclic AMP	18-22	cAMP responsive element binding protein 1	Mus musculus	167-171
8254739-6	1994	One sequence motif is shown to constitutively bind CREB- and Jun-related proteins in both keratinocytes and fibroblasts, whereas the other is a target for TPA-induced c-Rel/p65(NF-kappa B)-binding activity specifically in keratinocytes.	Tetradecanoylphorbol Acetate	155-158	cAMP responsive element binding protein 1	Mus musculus	51-56
8393039-8	1993	A phosphoprotein of appropriate molecular size for CREB was immunoprecipitated from anti-Ig plus forskolin treated BAL-17 B cells.	Colforsin	97-106	cAMP responsive element binding protein 1	Mus musculus	51-55
8393039-9	1993	These results suggest that CREB is present in primary B cells and that CRE-dependent gene expression is regulated by surface Ig either alone or in synergy with cAMP; the latter implies cross-talk between intracellular signaling pathways acting at the level of CREB.	Cyclic AMP	160-164	cAMP responsive element binding protein 1	Mus musculus	260-264
1532935-9	1992	Comparison of the CREB gene with the recently isolated CREM (cAMP responsive element modulator) cDNAs illustrates that the two genes have arisen by gene duplication and have diverged to encode transcriptional activators and repressors of the cAMP signal transduction pathway.	Cyclic AMP	61-65	cAMP responsive element binding protein 1	Mus musculus	18-22
1847666-1	1991	We isolated a gene from a mouse pituitary cDNA library that encodes a protein highly homologous to nuclear factor CREB, an activator of cAMP-responsive promoter elements (CREs).	Cyclic AMP	136-140	cAMP responsive element binding protein 1	Mus musculus	114-118
1847666-6	1991	CREM proteins reveal the same efficiency and specificity of binding to CRE sequences as CREB, but in contrast to CREB, CREM acts as a down-regulator of cAMP-induced transcription.	Cyclic AMP	152-156	cAMP responsive element binding protein 1	Mus musculus	88-92
1847666-6	1991	CREM proteins reveal the same efficiency and specificity of binding to CRE sequences as CREB, but in contrast to CREB, CREM acts as a down-regulator of cAMP-induced transcription.	Cyclic AMP	152-156	cAMP responsive element binding protein 1	Mus musculus	113-117
2140597-7	1990	Specifically, 50-70% structural similarity was observed between the basic domain of the DNA binding region of the nuclear proto-oncogene products c-fos and its related antigen fra-1, c-jun and the cAMP-responsive DNA binding protein CREB, with part of the N-terminal half region of helix 1b of vimentin.	Cyclic AMP	197-201	cAMP responsive element binding protein 1	Mus musculus	233-237
33972436-6	2021	Utilizing loss- and gain-of-function approaches in cultured epithelia and murine colonoids, we demonstrate that EA elicits prominent CREB phosphorylation through cyclic AMP-independent mechanisms that requires elements of the mitogen-activated protein kinase signaling pathway.	Cyclic AMP	162-172	cAMP responsive element binding protein 1	Mus musculus	133-137
33815562-9	2021	In addition, ChAT, mAchR, and CREB mRNA levels were increased in the hippocampus compared with the scopolamine group.	Scopolamine	99-110	cAMP responsive element binding protein 1	Mus musculus	30-34
33767622-9	2021	Alcohol altered the levels of several neurotransmitters and neurotrophic factors in the brain including gamma-Aminobutyric acid (GABA), corticotropin-releasing factor, cAMP response element-binding protein (CREB) and brain-derived neurotrophic factor.	Alcohols	0-7	cAMP responsive element binding protein 1	Mus musculus	168-205
33767622-9	2021	Alcohol altered the levels of several neurotransmitters and neurotrophic factors in the brain including gamma-Aminobutyric acid (GABA), corticotropin-releasing factor, cAMP response element-binding protein (CREB) and brain-derived neurotrophic factor.	Alcohols	0-7	cAMP responsive element binding protein 1	Mus musculus	207-211
34697992-10	2021	Mechanistically, Valsartan ameliorated high glucose-repressed endothelial cAMP-responsive element-binding protein (CREB) signaling activation.	Valsartan	17-26	cAMP responsive element binding protein 1	Mus musculus	74-113
33233731-7	2020	Carvedilol treatment led to the downregulation of phosphor-cAMP response element-binding protein (CREB).	Carvedilol	0-10	cAMP responsive element binding protein 1	Mus musculus	98-102
17147806-0	2006	Ethanol sensitivity: a central role for CREB transcription regulation in the cerebellum.	Ethanol	0-7	cAMP responsive element binding protein 1	Mus musculus	40-44
17147806-13	2006	CONCLUSION: These observations collectively suggest that ethanol sensitivity, as it relates to the cerebellum, may be associated with CREB transcription activity.	Ethanol	57-64	cAMP responsive element binding protein 1	Mus musculus	134-138
34838579-0	2022	Role of the cAMP-PKA-CREB-BDNF pathway in abnormal behaviours of serotonin transporter knockout mice.	Cyclic AMP	12-16	cAMP responsive element binding protein 1	Mus musculus	21-25
34838579-0	2022	Role of the cAMP-PKA-CREB-BDNF pathway in abnormal behaviours of serotonin transporter knockout mice.	Serotonin	65-74	cAMP responsive element binding protein 1	Mus musculus	21-25
34954642-10	2022	Oral administration of RQ-00490721 inhibited the CRHR2 agonist-induced phosphorylation of cAMP-response element binding protein (CREB) in the heart, which regulates a transcription activator involved in heart failure.	rq-00490721	23-34	cAMP responsive element binding protein 1	Mus musculus	90-127
34954642-10	2022	Oral administration of RQ-00490721 inhibited the CRHR2 agonist-induced phosphorylation of cAMP-response element binding protein (CREB) in the heart, which regulates a transcription activator involved in heart failure.	rq-00490721	23-34	cAMP responsive element binding protein 1	Mus musculus	129-133
34647651-0	2022	Modafinil rescues repeated morphine-induced synaptic and behavioural impairments via activation of D1R-ERK-CREB pathway in medial prefrontal cortex.	Modafinil	0-9	cAMP responsive element binding protein 1	Mus musculus	107-111
34647651-8	2022	Local infusion of D1R antagonist SCH-23390 reverses the morphine-induced synaptic abnormalities and activation of the D1R-ERK-CREB pathway in medial prefrontal cortex (mPFC).	SCH 23390	33-42	cAMP responsive element binding protein 1	Mus musculus	126-130
34647651-8	2022	Local infusion of D1R antagonist SCH-23390 reverses the morphine-induced synaptic abnormalities and activation of the D1R-ERK-CREB pathway in medial prefrontal cortex (mPFC).	Morphine	56-64	cAMP responsive element binding protein 1	Mus musculus	126-130
34774532-2	2022	Currently, besides to the monoaminergic system, the brain-derived neurotrophic factor (BDNF)-cAMP response element-binding protein (CREB) signaling is one of the most attractive signaling pathways for treating depression.	Cyclic AMP	93-97	cAMP responsive element binding protein 1	Mus musculus	132-136
34563511-8	2022	Additionally, thioperamide rescued the decrease of cyclic AMP response element-binding protein (CREB) phosphorylation and suppressed the phosphorylated P65 nuclear factor kappa B (p-P65 NF-kappaB) in APP/PS1 Tg mice.	thioperamide	14-26	cAMP responsive element binding protein 1	Mus musculus	51-94
34563511-8	2022	Additionally, thioperamide rescued the decrease of cyclic AMP response element-binding protein (CREB) phosphorylation and suppressed the phosphorylated P65 nuclear factor kappa B (p-P65 NF-kappaB) in APP/PS1 Tg mice.	thioperamide	14-26	cAMP responsive element binding protein 1	Mus musculus	96-100
34563511-9	2022	H89, an inhibitor of CREB signaling, abolished these effects of thioperamide to suppress gliosis and proinflammatory cytokine release.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	0-3	cAMP responsive element binding protein 1	Mus musculus	21-25
34563511-9	2022	H89, an inhibitor of CREB signaling, abolished these effects of thioperamide to suppress gliosis and proinflammatory cytokine release.	thioperamide	64-76	cAMP responsive element binding protein 1	Mus musculus	21-25
34563511-11	2022	Taken together, these results suggested the H3R antagonist thioperamide improved cognitive impairment in APP/PS1 Tg mice via modulation of the CREB-mediated gliosis and inflammation inhibiting, which contributed to Abeta clearance.	thioperamide	59-71	cAMP responsive element binding protein 1	Mus musculus	143-147
34563511-11	2022	Taken together, these results suggested the H3R antagonist thioperamide improved cognitive impairment in APP/PS1 Tg mice via modulation of the CREB-mediated gliosis and inflammation inhibiting, which contributed to Abeta clearance.	UNII-042A8N37WH	215-220	cAMP responsive element binding protein 1	Mus musculus	143-147
34606743-6	2022	Lowering O2 increases the responsiveness of the Star promoter towards cAMP and PKA mediates activation/phosphorylation (P) of several transcriptional factors, including cJUN and cAMP response element-binding protein (CREB), whose functionality is linked to HIF1 through utilization of CREB-binding protein (CBP).	Oxygen	9-11	cAMP responsive element binding protein 1	Mus musculus	178-215
34606743-6	2022	Lowering O2 increases the responsiveness of the Star promoter towards cAMP and PKA mediates activation/phosphorylation (P) of several transcriptional factors, including cJUN and cAMP response element-binding protein (CREB), whose functionality is linked to HIF1 through utilization of CREB-binding protein (CBP).	Oxygen	9-11	cAMP responsive element binding protein 1	Mus musculus	217-221
34606743-6	2022	Lowering O2 increases the responsiveness of the Star promoter towards cAMP and PKA mediates activation/phosphorylation (P) of several transcriptional factors, including cJUN and cAMP response element-binding protein (CREB), whose functionality is linked to HIF1 through utilization of CREB-binding protein (CBP).	Cyclic AMP	70-74	cAMP responsive element binding protein 1	Mus musculus	178-215
34606743-6	2022	Lowering O2 increases the responsiveness of the Star promoter towards cAMP and PKA mediates activation/phosphorylation (P) of several transcriptional factors, including cJUN and cAMP response element-binding protein (CREB), whose functionality is linked to HIF1 through utilization of CREB-binding protein (CBP).	Cyclic AMP	70-74	cAMP responsive element binding protein 1	Mus musculus	217-221
34280464-2	2022	Here we provide direct evidence that canonical cAMP/Creb signaling through adrenergic receptors can regulate HFSC activation and the hair cycle.	Cyclic AMP	47-51	cAMP responsive element binding protein 1	Mus musculus	52-56
34751416-0	2022	Polydatin protects neuronal cells from hydrogen peroxide damage by activating CREB/Ngb signaling.	polydatin	0-9	cAMP responsive element binding protein 1	Mus musculus	78-82
34751416-4	2022	The current study suggested that PD activates AKT/cAMP response element-binding protein (CREB) signaling and induces neuroglobin (Ngb) to protect neuronal cells from hydrogen peroxide (H2O2) in vitro.	Cyclic AMP	50-54	cAMP responsive element binding protein 1	Mus musculus	89-93
34751416-11	2022	The results indicated that PD protected neuronal cells from H2O2 by activating CREB/Ngb signaling in neuronal cells, indicating that PD has a neuroprotective effect against neurodegenerative diseases.	Hydrogen Peroxide	60-64	cAMP responsive element binding protein 1	Mus musculus	79-83
34965216-1	2021	This study sought to investigate whether repetitive transcranial magnetic stimulation (rTMS) could alleviate cognitive dysfunction in SAMP8 mice by reducing cell apoptosis and activating the cAMP/PKA/CREB signalling pathway.	Cyclic AMP	191-195	cAMP responsive element binding protein 1	Mus musculus	200-204
34965216-8	2021	Furthermore, rTMS activated the cAMP/PKA/CREB signalling pathway.	Cyclic AMP	32-36	cAMP responsive element binding protein 1	Mus musculus	41-45
34965216-9	2021	These results showed that rTMS could ameliorate cognitive deficits in AD mice by inhibiting apoptosis via activation the cAMP/PKA/CREB signalling pathway.	Cyclic AMP	121-125	cAMP responsive element binding protein 1	Mus musculus	130-134
34992716-4	2021	A set of processes leading to this outcome starts with the generation of ROS, attributed to the interaction of Pt with complex I of the mitochondrial respiratory chain, and spreads to involve Ca2+ mobilization from the ER/mitochondria pool, activation of CREB and AMPK, and inhibition of mTORC1.	ros	73-76	cAMP responsive element binding protein 1	Mus musculus	255-259
34987399-6	2021	The results showed that SA could alleviate the immunosuppression induced by cyclophosphamide in mice and regulate the protein expression of Jun, Trp53, and Creb1 in the spleen tissue of mice, together with the transcription factors Atf4 and E2f2.	schizandrin	24-26	cAMP responsive element binding protein 1	Mus musculus	156-161
34987399-6	2021	The results showed that SA could alleviate the immunosuppression induced by cyclophosphamide in mice and regulate the protein expression of Jun, Trp53, and Creb1 in the spleen tissue of mice, together with the transcription factors Atf4 and E2f2.	Cyclophosphamide	76-92	cAMP responsive element binding protein 1	Mus musculus	156-161
34966284-8	2021	The increased expression of PDE2A and PDE4 subtypes (PDE4A, PDE4B and PDE4D), and decreased levels of cAMP/cGMP, pCREB/CREB and BDNF induced by Abeta were also blocked by chronic treatment of baicalein for 14 days.	baicalein	192-201	cAMP responsive element binding protein 1	Mus musculus	119-123
34890760-8	2022	NaB treatment upregulated the expression of the growth factor-related factors PPARgamma, CREB, and BDNF in the brain tissues of HFD-fed mice.	nab	0-3	cAMP responsive element binding protein 1	Mus musculus	89-93
34864064-4	2022	KEY FINDINGS: Exposure to prednisone stimulated browning in 3 T3-L1 white adipocytes by increasing the expressions of core fat browning marker proteins (UCP1, PGC-1alpha and PRDM16) as well as beige-specific genes (Cd137, Cidea, Cited1, and Tbx1) via ATF2 and CREB activation mediated by p38 MAPK and ERK signaling, respectively.	Prednisone	26-36	cAMP responsive element binding protein 1	Mus musculus	260-264
34883151-11	2022	Hyperoside also inhibited the inflammasome activation by reducing the expression of NLRP3, apoptosis-associated speck-like protein containing caspases recruitment domain (ASC), and caspase-1 and increased PACAP content and CREB phosphorylation in the SNpc of the mice.	hyperoside	0-10	cAMP responsive element binding protein 1	Mus musculus	223-227
34946730-14	2021	Therefore, RF may have decreased melanin synthesis by increasing HSP70 and decreasing p53, thus decreasing MC1R/CREB/MITF and tyrosinase activity.	Melanins	33-40	cAMP responsive element binding protein 1	Mus musculus	112-116
34821902-6	2021	Moreover, GA could up-regulate the expression of neuronal survival and growth-related proteins, such as BDNF, p-ERK, p-CREB, p-Akt, p-GSK3beta, Nrf2, p-mTOR, and p-S6, in the hippocampi of 5-FU-treated mice.	Fluorouracil	189-193	cAMP responsive element binding protein 1	Mus musculus	119-123
34697992-10	2021	Mechanistically, Valsartan ameliorated high glucose-repressed endothelial cAMP-responsive element-binding protein (CREB) signaling activation.	Valsartan	17-26	cAMP responsive element binding protein 1	Mus musculus	115-119
34697992-10	2021	Mechanistically, Valsartan ameliorated high glucose-repressed endothelial cAMP-responsive element-binding protein (CREB) signaling activation.	Glucose	44-51	cAMP responsive element binding protein 1	Mus musculus	74-113
34697992-10	2021	Mechanistically, Valsartan ameliorated high glucose-repressed endothelial cAMP-responsive element-binding protein (CREB) signaling activation.	Glucose	44-51	cAMP responsive element binding protein 1	Mus musculus	115-119
34697992-11	2021	The blockage of CREB activation by PKA inhibitor H89 abolished the action of Valsartan, suggesting its dependence on CREB signaling.	Valsartan	77-86	cAMP responsive element binding protein 1	Mus musculus	16-20
34697992-11	2021	The blockage of CREB activation by PKA inhibitor H89 abolished the action of Valsartan, suggesting its dependence on CREB signaling.	Valsartan	77-86	cAMP responsive element binding protein 1	Mus musculus	117-121
34697992-13	2021	These effects of Valsartan require cellular CREB signaling in brain endothelial cells.	Valsartan	17-26	cAMP responsive element binding protein 1	Mus musculus	44-48
34650622-10	2021	In addition, the cAMP/ protein kinase A (PKA)/cAMP response element-binding protein (CREB) signaling pathway was also positively regulated by CD73 and Ado.	Cyclic AMP	17-21	cAMP responsive element binding protein 1	Mus musculus	85-89
34650622-10	2021	In addition, the cAMP/ protein kinase A (PKA)/cAMP response element-binding protein (CREB) signaling pathway was also positively regulated by CD73 and Ado.	Cyclic AMP	46-50	cAMP responsive element binding protein 1	Mus musculus	85-89
34650622-10	2021	In addition, the cAMP/ protein kinase A (PKA)/cAMP response element-binding protein (CREB) signaling pathway was also positively regulated by CD73 and Ado.	Adenosine	151-154	cAMP responsive element binding protein 1	Mus musculus	85-89
34650622-11	2021	In conclusion, CD73 could inhibit DRG neuronal apoptosis by promoting the Ado/cAMP/PKA/CREB pathway.	Adenosine	74-77	cAMP responsive element binding protein 1	Mus musculus	87-91
34865170-9	2022	Also, SOMCL-668 reversed chronic PCP-induced down-regulation in expression of frontal cortical p-AKT/AKT, p-CREB/CREB and BDNF in wide-type but not sigma-1 knockout mice.	3-methylphenyl-2,3,4,5-tetrahydro-1H-benzo(d)azepin-7-ol	6-15	cAMP responsive element binding protein 1	Mus musculus	108-112
34784780-10	2021	TBPH could significantly decrease the levels of BDNF, p-CREB, and PSD-95 in the hippocampus, and these TBPH-induced neurotoxic effects were attenuated by CUR.	bis(2-ethylhexyl) 2,3,4,5-tetrabromophthalate	0-4	cAMP responsive element binding protein 1	Mus musculus	56-60
34865170-9	2022	Also, SOMCL-668 reversed chronic PCP-induced down-regulation in expression of frontal cortical p-AKT/AKT, p-CREB/CREB and BDNF in wide-type but not sigma-1 knockout mice.	3-methylphenyl-2,3,4,5-tetrahydro-1H-benzo(d)azepin-7-ol	6-15	cAMP responsive element binding protein 1	Mus musculus	113-117
34865170-9	2022	Also, SOMCL-668 reversed chronic PCP-induced down-regulation in expression of frontal cortical p-AKT/AKT, p-CREB/CREB and BDNF in wide-type but not sigma-1 knockout mice.	Phencyclidine	33-36	cAMP responsive element binding protein 1	Mus musculus	108-112
34719258-3	2021	This study investigated the impact of CCR5 activation on neuronal pyroptosis and the underlying mechanism involving cAMP-dependent PKA (protein kinase A)/CREB (cAMP response element binding)/NLRP1 (nucleotide-binding domain leucine-rich repeat pyrin domain containing 1) pathway after experimental intracerebral hemorrhage (ICH).	Cyclic AMP	116-120	cAMP responsive element binding protein 1	Mus musculus	154-158
34719258-3	2021	This study investigated the impact of CCR5 activation on neuronal pyroptosis and the underlying mechanism involving cAMP-dependent PKA (protein kinase A)/CREB (cAMP response element binding)/NLRP1 (nucleotide-binding domain leucine-rich repeat pyrin domain containing 1) pathway after experimental intracerebral hemorrhage (ICH).	Cyclic AMP	160-164	cAMP responsive element binding protein 1	Mus musculus	154-158
34865170-9	2022	Also, SOMCL-668 reversed chronic PCP-induced down-regulation in expression of frontal cortical p-AKT/AKT, p-CREB/CREB and BDNF in wide-type but not sigma-1 knockout mice.	Phencyclidine	33-36	cAMP responsive element binding protein 1	Mus musculus	113-117
34819637-0	2022	Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine.	(R)-Ketamine	80-92	cAMP responsive element binding protein 1	Mus musculus	21-25
34650622-0	2021	Ecto-5"-nucleotidase (CD73) inhibits dorsal root ganglion neuronal apoptosis by promoting the Ado/cAMP/PKA/CREB pathway.	Adenosine	94-97	cAMP responsive element binding protein 1	Mus musculus	107-111
34650622-0	2021	Ecto-5"-nucleotidase (CD73) inhibits dorsal root ganglion neuronal apoptosis by promoting the Ado/cAMP/PKA/CREB pathway.	Cyclic AMP	98-102	cAMP responsive element binding protein 1	Mus musculus	107-111
34819637-5	2022	(R)-ketamine increased the expression of NRBP1, brain-derived neurotrophic factor (BDNF), and phosphorylated cAMP response element binding protein (p-CREB)/CREB ratio in primary microglia cultures thorough the extracellular signal-regulated kinase (ERK) activation.	(R)-Ketamine	0-12	cAMP responsive element binding protein 1	Mus musculus	150-154
34819637-5	2022	(R)-ketamine increased the expression of NRBP1, brain-derived neurotrophic factor (BDNF), and phosphorylated cAMP response element binding protein (p-CREB)/CREB ratio in primary microglia cultures thorough the extracellular signal-regulated kinase (ERK) activation.	(R)-Ketamine	0-12	cAMP responsive element binding protein 1	Mus musculus	156-160
34819637-5	2022	(R)-ketamine increased the expression of NRBP1, brain-derived neurotrophic factor (BDNF), and phosphorylated cAMP response element binding protein (p-CREB)/CREB ratio in primary microglia cultures thorough the extracellular signal-regulated kinase (ERK) activation.	Cyclic AMP	109-113	cAMP responsive element binding protein 1	Mus musculus	150-154
34819637-5	2022	(R)-ketamine increased the expression of NRBP1, brain-derived neurotrophic factor (BDNF), and phosphorylated cAMP response element binding protein (p-CREB)/CREB ratio in primary microglia cultures thorough the extracellular signal-regulated kinase (ERK) activation.	Cyclic AMP	109-113	cAMP responsive element binding protein 1	Mus musculus	156-160
34819637-6	2022	Furthermore, (R)-ketamine could activate BDNF transcription through activation of CREB as well as MeCP2 (methyl-CpG binding protein 2) suppression in microglia.	(R)-Ketamine	13-25	cAMP responsive element binding protein 1	Mus musculus	82-86
34819637-8	2022	injection of CREB-DNA/RNA heteroduplex oligonucleotides (CREB-HDO) or BDNF exon IV-HDO blocked the antidepressant-like effects of (R)-ketamine in CSDS susceptible mice.	Oligonucleotides	39-55	cAMP responsive element binding protein 1	Mus musculus	57-61
34819637-8	2022	injection of CREB-DNA/RNA heteroduplex oligonucleotides (CREB-HDO) or BDNF exon IV-HDO blocked the antidepressant-like effects of (R)-ketamine in CSDS susceptible mice.	(R)-Ketamine	130-142	cAMP responsive element binding protein 1	Mus musculus	57-61
34819637-13	2022	injection of CREB-HDO, BDNF exon IV-HDO or MCLs blocked the beneficial effects of (R)-ketamine on the reduced dendritic spine density in the mPFC of CSDS susceptible mice.	(R)-Ketamine	82-94	cAMP responsive element binding protein 1	Mus musculus	13-17
34819637-14	2022	These data suggest a novel ERK-NRBP1-CREB-BDNF pathways in microglia underlying antidepressant-like effects of (R)-ketamine.	(R)-Ketamine	111-123	cAMP responsive element binding protein 1	Mus musculus	37-41
34560247-10	2021	From the perspective of pigment production regulation pathways, western blot showed that the pigment accumulation caused by ermanin was closely related to the CREB-MITF pathways, it activated CREB, TYR, TRP-1, and DCT proteins.	ermanin	124-131	cAMP responsive element binding protein 1	Mus musculus	159-163
34560247-10	2021	From the perspective of pigment production regulation pathways, western blot showed that the pigment accumulation caused by ermanin was closely related to the CREB-MITF pathways, it activated CREB, TYR, TRP-1, and DCT proteins.	ermanin	124-131	cAMP responsive element binding protein 1	Mus musculus	192-196
34560247-10	2021	From the perspective of pigment production regulation pathways, western blot showed that the pigment accumulation caused by ermanin was closely related to the CREB-MITF pathways, it activated CREB, TYR, TRP-1, and DCT proteins.	Tyrosine	198-201	cAMP responsive element binding protein 1	Mus musculus	159-163
34560247-12	2021	Our findings revealed the potential mechanisms by which ermanin promoted the production of melanin through activated CREB-MITF signaling pathway and ROS function as signaling messengers are beneficial to melanin production and thereby will help develop novel therapeutic approaches for vitiligo.	ermanin	56-63	cAMP responsive element binding protein 1	Mus musculus	117-121
34560247-12	2021	Our findings revealed the potential mechanisms by which ermanin promoted the production of melanin through activated CREB-MITF signaling pathway and ROS function as signaling messengers are beneficial to melanin production and thereby will help develop novel therapeutic approaches for vitiligo.	Melanins	91-98	cAMP responsive element binding protein 1	Mus musculus	117-121
34812274-6	2021	Of the three tested compounds, (E)-3-(3-(4-(dimethylamino)phenyl)acryloyl)-4-hydroxy-2H-chromen-2-one (LM-021) was observed to increase CREB-mediated gene expression through protein kinase A (PKA), Ca2+/calmodulin-dependent protein kinase II (CaMKII), and extracellular signal-regulated kinase (ERK) in CRE-GFP reporter cells.	(e)-3-(3-(4-(dimethylamino)phenyl)acryloyl)-4-hydroxy-2h-chromen-2-one (lm-021	31-109	cAMP responsive element binding protein 1	Mus musculus	136-140
34956454-6	2021	RESULTS: MiR-433 was downregulated, and CREB1 was upregulated in the NSCLC tissues, and the methylating rate of the C-phosphate-G (CpG) island in the miR-433 promoter region was enhanced.	c-phosphate	116-127	cAMP responsive element binding protein 1	Mus musculus	40-45
34363644-7	2021	Oral spermidine promoted BAT activation and metabolic adaptation of skeletal muscle in HFD-fed mice, evidenced by UCP-1 induction and CREB activation in both tissues.	Spermidine	5-15	cAMP responsive element binding protein 1	Mus musculus	134-138
34815805-11	2021	Using primary bone marrow-derived macrophages, we showed that cholesterol sulfate could attenuate the pro-inflammatory polarization of macrophages under both normal and oxygen-glucose deprivation conditions by regulating the levels of nicotinamide adenine dinucleotide phosphate (NADPH), reactive oxygen species (ROS), and activating the AMP-activated protein kinase (AMPK) - cAMP responsive element-binding protein (CREB) signaling pathway.	cholesteryl sulfate	62-81	cAMP responsive element binding protein 1	Mus musculus	376-415
34815805-11	2021	Using primary bone marrow-derived macrophages, we showed that cholesterol sulfate could attenuate the pro-inflammatory polarization of macrophages under both normal and oxygen-glucose deprivation conditions by regulating the levels of nicotinamide adenine dinucleotide phosphate (NADPH), reactive oxygen species (ROS), and activating the AMP-activated protein kinase (AMPK) - cAMP responsive element-binding protein (CREB) signaling pathway.	cholesteryl sulfate	62-81	cAMP responsive element binding protein 1	Mus musculus	417-421
34607805-0	2021	Phosphorylation of CREB at Serine 142 and 143 is essential for visual cortex plasticity.	Serine	27-33	cAMP responsive element binding protein 1	Mus musculus	19-23
34607805-2	2021	For instance, the role of CREB via phosphorylation at the amino-acid residue Serine (Ser) 133 in expressing plasticity-related genes and activity-dependent neuronal plasticity processes has been extensively demonstrated.	Serine	77-83	cAMP responsive element binding protein 1	Mus musculus	26-30
34607805-2	2021	For instance, the role of CREB via phosphorylation at the amino-acid residue Serine (Ser) 133 in expressing plasticity-related genes and activity-dependent neuronal plasticity processes has been extensively demonstrated.	Serine	85-88	cAMP responsive element binding protein 1	Mus musculus	26-30
34607805-3	2021	However, much less is known about the role of CREB phosphorylation at Ser 142 and 143.	Serine	70-73	cAMP responsive element binding protein 1	Mus musculus	46-50
34607805-6	2021	We demonstrated by immunohistochemistry of cortical neuronal cultures that the expression of Arc, a known plasticity-related gene, requires triple phosphorylation of CREB at Ser 133, 142, and 143.	Serine	174-177	cAMP responsive element binding protein 1	Mus musculus	166-170
34607805-7	2021	Moreover, we recorded visually-evoked field potentials in awake mice before and after a 7-day period of monocular deprivation to show that, in addition to CREB phosphorylation at Ser 133, ocular dominance plasticity in the visual cortex also requires CREB phosphorylation at Ser 142/143.	Serine	179-182	cAMP responsive element binding protein 1	Mus musculus	155-159
34676557-5	2022	Mechanistically, we found copper, on the one hand, prevented phosphorylation of cAMP response element binding protein (CREB) to decrease expression its downstream target protein Brain-derived neurotrophic factor (BDNF), and to decrease mitochondrial membrane potential and Bcl-2/Bax ratio; on the other hand, copper-induced reactive oxygen species (ROS), promoted lipid peroxidation, reduced antioxidant enzyme activity of GSH-Px.	gsh-px	423-429	cAMP responsive element binding protein 1	Mus musculus	80-117
34676557-5	2022	Mechanistically, we found copper, on the one hand, prevented phosphorylation of cAMP response element binding protein (CREB) to decrease expression its downstream target protein Brain-derived neurotrophic factor (BDNF), and to decrease mitochondrial membrane potential and Bcl-2/Bax ratio; on the other hand, copper-induced reactive oxygen species (ROS), promoted lipid peroxidation, reduced antioxidant enzyme activity of GSH-Px.	gsh-px	423-429	cAMP responsive element binding protein 1	Mus musculus	119-123
34676557-6	2022	Copper-induced oxidative damage further decreased the phosphorylation of CREB, decreased expression of Bcl-2, enhanced expression of Bax, and accelerated the dissociation of keap1-Nrf2 complex, promoted the nuclear translocation of Nrf2, stimulate the expression of antioxidant molecules HO-1 and NQO1.	Copper	0-6	cAMP responsive element binding protein 1	Mus musculus	73-77
34676557-7	2022	In conclusion, we found copper inhibited pCREB/BDNF signaling pathway by prevent CREB from phosphorylation, further found that oxidative damage not only inhibited neuroprotective signaling pathways and induced apoptosis, but activated antioxidant protection signals Nrf2/HO-1/NQO1 signaling pathway.	Copper	24-30	cAMP responsive element binding protein 1	Mus musculus	81-85
34815795-1	2021	Background: Although CREB phosphorylation is known to be essential in UVB/cAMP-stimulated melanogenesis, CREB null mice did not show identifiable pigmentation phenotypes.	Cyclic AMP	74-78	cAMP responsive element binding protein 1	Mus musculus	21-25
34720870-10	2021	Lactate accumulation and abnormal lactate transport occurred in Pdha1 -/- mice, and the cyclic AMP-protein kinase A-cAMP response element-binding protein (cAMP/PKA/CREB) pathway was inhibited.	Cyclic AMP	116-120	cAMP responsive element binding protein 1	Mus musculus	164-168
34720870-11	2021	Conclusion: Lactate accumulation caused by PDHA1 deficiency in the hippocampus may impair cognitive function by inhibiting the cAMP/PKA/CREB pathway.	Lactic Acid	12-19	cAMP responsive element binding protein 1	Mus musculus	136-140
34720870-11	2021	Conclusion: Lactate accumulation caused by PDHA1 deficiency in the hippocampus may impair cognitive function by inhibiting the cAMP/PKA/CREB pathway.	Cyclic AMP	127-131	cAMP responsive element binding protein 1	Mus musculus	136-140
34289399-0	2021	Melatonin improves learning and memory of mice with chronic social isolation stress via an interaction between microglia polarization and BDNF/TrkB/CREB signaling pathway.	Melatonin	0-9	cAMP responsive element binding protein 1	Mus musculus	148-152
34289399-10	2021	Taken together, melatonin therapy could alleviate memory impairment through switching microglial polarization from M1 to M2 phenotype along with altered expression and function in the BDNF/TrkB/CREB signaling pathway.	Melatonin	16-25	cAMP responsive element binding protein 1	Mus musculus	194-198
34324855-0	2021	Diosgenin exerts anti-tumor effects through inactivation of cAMP/PKA/CREB signaling pathway in colorectal cancer.	Diosgenin	0-9	cAMP responsive element binding protein 1	Mus musculus	69-73
34324855-5	2021	Intriguingly, mechanistic study suggests those phenotypes involved DSG inhibited cAMP/PKA/CREB pathway in CRC cells, and result to inhibit the phosphorylation of CREB to regulate the transcription of genes above-mentioned.	Cyclic AMP	81-85	cAMP responsive element binding protein 1	Mus musculus	162-166
34606526-6	2021	Notably, the ISO treatment activated the CREB/BDNF pathway and increased neurotrophic factors in the brains of mice.	3-methylquercetin	13-16	cAMP responsive element binding protein 1	Mus musculus	41-45
34790800-0	2021	MiR-139-5p has an antidepressant-like effect by targeting phosphodiesterase 4D to activate the cAMP/PKA/CREB signaling pathway.	mir-139-5p	0-10	cAMP responsive element binding protein 1	Mus musculus	104-108
34790800-0	2021	MiR-139-5p has an antidepressant-like effect by targeting phosphodiesterase 4D to activate the cAMP/PKA/CREB signaling pathway.	Cyclic AMP	95-99	cAMP responsive element binding protein 1	Mus musculus	104-108
34790800-10	2021	Moreover, in experiments in vitro, miR-139-5p mimic repressed PDE4D expression in HT-22 cells, but promoted phosphorylated cyclic-AMP response element-binding protein (p-CREB) and brain-derived neurotrophic factor (BDNF) expression.	-139-5p	38-45	cAMP responsive element binding protein 1	Mus musculus	170-174
34790800-10	2021	Moreover, in experiments in vitro, miR-139-5p mimic repressed PDE4D expression in HT-22 cells, but promoted phosphorylated cyclic-AMP response element-binding protein (p-CREB) and brain-derived neurotrophic factor (BDNF) expression.	Cyclic AMP	123-133	cAMP responsive element binding protein 1	Mus musculus	170-174
34790800-13	2021	Conclusions: Our findings suggested that miR-139-5p acted like an antidepressant by targeting PDE4D, thereby regulating the cAMP/protein kinase A (PKA)/CREB/BDNF pathway to improve depression.	mir-139-5p	41-51	cAMP responsive element binding protein 1	Mus musculus	152-156
34790800-13	2021	Conclusions: Our findings suggested that miR-139-5p acted like an antidepressant by targeting PDE4D, thereby regulating the cAMP/protein kinase A (PKA)/CREB/BDNF pathway to improve depression.	Cyclic AMP	124-128	cAMP responsive element binding protein 1	Mus musculus	152-156
34416629-0	2021	Albendazole-loaded cubosomes interrupt the ERK1/2-HIF-1alpha-p300/CREB axis in mice intoxicated with diethylnitrosamine: A new paradigm in drug repurposing for the inhibition of hepatocellular carcinoma progression.	Albendazole	0-11	cAMP responsive element binding protein 1	Mus musculus	66-70
34416629-0	2021	Albendazole-loaded cubosomes interrupt the ERK1/2-HIF-1alpha-p300/CREB axis in mice intoxicated with diethylnitrosamine: A new paradigm in drug repurposing for the inhibition of hepatocellular carcinoma progression.	Diethylnitrosamine	101-119	cAMP responsive element binding protein 1	Mus musculus	66-70
34473369-9	2021	Inhibitors of ERK1/2 and CREB attenuated ISO-induced Per1 expression.	Isoproterenol	41-44	cAMP responsive element binding protein 1	Mus musculus	25-29
34302909-12	2021	These pharmacological studies indicate that NES-1 and NLP acts through the cAMP/PKA/CREB cellular pathway to stimulate POMC synthesis.	Cyclic AMP	75-79	cAMP responsive element binding protein 1	Mus musculus	84-88
34302909-15	2021	This stimulatory effect is mediated by an uncharacterized GPCR that utilizes the cAMP/PKA/CREB pathway.	Cyclic AMP	81-85	cAMP responsive element binding protein 1	Mus musculus	90-94
34363644-8	2021	Notably, oral spermidine upregulated tyrosine hydroxylase in hypothalamus of HFD-fed mice; spermidine treatment increased tyrosine hydroxylase expression and norepinephrine production in neurocytes, which led to CREB activation and UCP-1 induction in brown adipocytes and myotubes.	Spermidine	91-101	cAMP responsive element binding protein 1	Mus musculus	212-216
34363644-8	2021	Notably, oral spermidine upregulated tyrosine hydroxylase in hypothalamus of HFD-fed mice; spermidine treatment increased tyrosine hydroxylase expression and norepinephrine production in neurocytes, which led to CREB activation and UCP-1 induction in brown adipocytes and myotubes.	Norepinephrine	158-172	cAMP responsive element binding protein 1	Mus musculus	212-216
34749728-13	2021	5-MTP suppressed HFD-induced CREB activation in aortic tissues and Pam3-induced CREB and NF-kappaB activation in SMCs.	pam3	67-71	cAMP responsive element binding protein 1	Mus musculus	80-84
34607805-7	2021	Moreover, we recorded visually-evoked field potentials in awake mice before and after a 7-day period of monocular deprivation to show that, in addition to CREB phosphorylation at Ser 133, ocular dominance plasticity in the visual cortex also requires CREB phosphorylation at Ser 142/143.	Serine	275-278	cAMP responsive element binding protein 1	Mus musculus	251-255
34607805-8	2021	Our findings suggest that Ser 142/143 phosphorylation is an additional post-translational modification of CREB that triggers the expression of specific target genes and activity-dependent neuronal plasticity processes.SIGNIFICANCE STATEMENTThe transcription factor CREB triggers the expression of numerous different gene clusters in response to different cellular stimuli.	Serine	26-29	cAMP responsive element binding protein 1	Mus musculus	106-110
34607805-8	2021	Our findings suggest that Ser 142/143 phosphorylation is an additional post-translational modification of CREB that triggers the expression of specific target genes and activity-dependent neuronal plasticity processes.SIGNIFICANCE STATEMENTThe transcription factor CREB triggers the expression of numerous different gene clusters in response to different cellular stimuli.	Serine	26-29	cAMP responsive element binding protein 1	Mus musculus	265-269
34607805-9	2021	Previous studies have shown that CREB can be activated by phosphorylation at several of its serine residues.	Serine	92-98	cAMP responsive element binding protein 1	Mus musculus	33-37
34607805-10	2021	We discovered that ocular dominance plasticity, a type of activity-dependent plasticity in the visual cortex, requires the phosphorylation of three different serine residues on CREB (Ser133, Ser142, and Ser143).	Serine	158-164	cAMP responsive element binding protein 1	Mus musculus	177-181
34829525-7	2021	Furthermore, melittin treatment activated the Tropomyosin-related kinase receptor B (TrkB)/cAMP Response Element-Binding (CREB)/Brain-derived neurotrophic factor (BDNF), contributing to neuronal neurogenesis, and regulating the normal function of synapses in the brain.	Cyclic AMP	91-95	cAMP responsive element binding protein 1	Mus musculus	122-126
34676557-5	2022	Mechanistically, we found copper, on the one hand, prevented phosphorylation of cAMP response element binding protein (CREB) to decrease expression its downstream target protein Brain-derived neurotrophic factor (BDNF), and to decrease mitochondrial membrane potential and Bcl-2/Bax ratio; on the other hand, copper-induced reactive oxygen species (ROS), promoted lipid peroxidation, reduced antioxidant enzyme activity of GSH-Px.	Copper	26-32	cAMP responsive element binding protein 1	Mus musculus	80-117
34676557-5	2022	Mechanistically, we found copper, on the one hand, prevented phosphorylation of cAMP response element binding protein (CREB) to decrease expression its downstream target protein Brain-derived neurotrophic factor (BDNF), and to decrease mitochondrial membrane potential and Bcl-2/Bax ratio; on the other hand, copper-induced reactive oxygen species (ROS), promoted lipid peroxidation, reduced antioxidant enzyme activity of GSH-Px.	Copper	26-32	cAMP responsive element binding protein 1	Mus musculus	119-123
34676557-5	2022	Mechanistically, we found copper, on the one hand, prevented phosphorylation of cAMP response element binding protein (CREB) to decrease expression its downstream target protein Brain-derived neurotrophic factor (BDNF), and to decrease mitochondrial membrane potential and Bcl-2/Bax ratio; on the other hand, copper-induced reactive oxygen species (ROS), promoted lipid peroxidation, reduced antioxidant enzyme activity of GSH-Px.	Copper	309-315	cAMP responsive element binding protein 1	Mus musculus	80-117
34676557-5	2022	Mechanistically, we found copper, on the one hand, prevented phosphorylation of cAMP response element binding protein (CREB) to decrease expression its downstream target protein Brain-derived neurotrophic factor (BDNF), and to decrease mitochondrial membrane potential and Bcl-2/Bax ratio; on the other hand, copper-induced reactive oxygen species (ROS), promoted lipid peroxidation, reduced antioxidant enzyme activity of GSH-Px.	Copper	309-315	cAMP responsive element binding protein 1	Mus musculus	119-123
34684653-5	2021	CB significantly enhanced Ca2+/calmodulin-dependent protein kinase II (CaMKII) and brain-derived neurotrophic factor (BDNF) and reduced the phospho-cAMP response element-binding protein (p-CREB)/CREB ratio.	Cyclic AMP	148-152	cAMP responsive element binding protein 1	Mus musculus	189-193
34363644-8	2021	Notably, oral spermidine upregulated tyrosine hydroxylase in hypothalamus of HFD-fed mice; spermidine treatment increased tyrosine hydroxylase expression and norepinephrine production in neurocytes, which led to CREB activation and UCP-1 induction in brown adipocytes and myotubes.	Spermidine	14-24	cAMP responsive element binding protein 1	Mus musculus	212-216
34312767-5	2021	Intriguingly, REMSD-induced defects in L/M functions and FC-induced PKA/CREB activation were restored upon increasing O-GlcNAc cycling with glucosamine (GlcN) or Thiamet G. Furthermore, Thiamet G restored the REMSD-induced decrease in dendritic spine density.	o-glcnac	118-126	cAMP responsive element binding protein 1	Mus musculus	72-76
34312767-5	2021	Intriguingly, REMSD-induced defects in L/M functions and FC-induced PKA/CREB activation were restored upon increasing O-GlcNAc cycling with glucosamine (GlcN) or Thiamet G. Furthermore, Thiamet G restored the REMSD-induced decrease in dendritic spine density.	Glucosamine	140-151	cAMP responsive element binding protein 1	Mus musculus	72-76
34312767-5	2021	Intriguingly, REMSD-induced defects in L/M functions and FC-induced PKA/CREB activation were restored upon increasing O-GlcNAc cycling with glucosamine (GlcN) or Thiamet G. Furthermore, Thiamet G restored the REMSD-induced decrease in dendritic spine density.	Glucosamine	153-157	cAMP responsive element binding protein 1	Mus musculus	72-76
34312767-5	2021	Intriguingly, REMSD-induced defects in L/M functions and FC-induced PKA/CREB activation were restored upon increasing O-GlcNAc cycling with glucosamine (GlcN) or Thiamet G. Furthermore, Thiamet G restored the REMSD-induced decrease in dendritic spine density.	thiamet	162-169	cAMP responsive element binding protein 1	Mus musculus	72-76
34312767-5	2021	Intriguingly, REMSD-induced defects in L/M functions and FC-induced PKA/CREB activation were restored upon increasing O-GlcNAc cycling with glucosamine (GlcN) or Thiamet G. Furthermore, Thiamet G restored the REMSD-induced decrease in dendritic spine density.	thiamet	186-193	cAMP responsive element binding protein 1	Mus musculus	72-76
34312767-6	2021	Suppression of O-GlcNAcylation by the glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitor, 6-diazo-5-oxo-L-norleucine (DON), or OGT inhibitor, OSMI-1, impaired memory function, and inhibited FC-induced PKA/CREB activation.	o-glcnacylation	15-30	cAMP responsive element binding protein 1	Mus musculus	219-223
34312767-6	2021	Suppression of O-GlcNAcylation by the glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitor, 6-diazo-5-oxo-L-norleucine (DON), or OGT inhibitor, OSMI-1, impaired memory function, and inhibited FC-induced PKA/CREB activation.	Diazooxonorleucine	104-130	cAMP responsive element binding protein 1	Mus musculus	219-223
34312767-6	2021	Suppression of O-GlcNAcylation by the glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitor, 6-diazo-5-oxo-L-norleucine (DON), or OGT inhibitor, OSMI-1, impaired memory function, and inhibited FC-induced PKA/CREB activation.	Diazooxonorleucine	132-135	cAMP responsive element binding protein 1	Mus musculus	219-223
34382261-0	2021	Orcinol glucoside improves the depressive-like behaviors of perimenopausal depression mice through modulating activity of hypothalamic-pituitary-adrenal/ovary axis and activating BDNF- TrkB-CREB signaling pathway.	Glucosides	8-17	cAMP responsive element binding protein 1	Mus musculus	190-194
34280458-0	2021	Baicalin Ameliorates Chronic Unpredictable Mild Stress-Induced Depression through the BDNF/ERK/CREB Signaling Pathway.	baicalin	0-8	cAMP responsive element binding protein 1	Mus musculus	95-99
34280458-1	2021	Brain-derived neurotrophic factor (BDNF) can activate the extracellular regulated protein kinase (ERK)/cAMP response element binding protein (CREB) cascade revealing an important role in antidepressant effects.	Cyclic AMP	103-107	cAMP responsive element binding protein 1	Mus musculus	142-146
34280458-2	2021	Here, we studied the neuroprotective effect of baicalin (BA) in mice with chronic unpredictable mild stress (CUMS)-induced via a BDNF/ERK/CREB signaling pathway.	baicalin	47-55	cAMP responsive element binding protein 1	Mus musculus	138-142
34280458-2	2021	Here, we studied the neuroprotective effect of baicalin (BA) in mice with chronic unpredictable mild stress (CUMS)-induced via a BDNF/ERK/CREB signaling pathway.	baicalin	57-59	cAMP responsive element binding protein 1	Mus musculus	138-142
34280458-9	2021	The protein ratios of p-ERK/ERK, p-CREB/CREB and ERK mRNA, and CREB mRNA expression decreased in the CUMS group (p <  0.01) and markedly increased in the FLU and BA groups (p <  0.05, p <  0.01).	Fluoxetine	154-157	cAMP responsive element binding protein 1	Mus musculus	35-39
34280458-9	2021	The protein ratios of p-ERK/ERK, p-CREB/CREB and ERK mRNA, and CREB mRNA expression decreased in the CUMS group (p <  0.01) and markedly increased in the FLU and BA groups (p <  0.05, p <  0.01).	Fluoxetine	154-157	cAMP responsive element binding protein 1	Mus musculus	40-44
34280458-9	2021	The protein ratios of p-ERK/ERK, p-CREB/CREB and ERK mRNA, and CREB mRNA expression decreased in the CUMS group (p <  0.01) and markedly increased in the FLU and BA groups (p <  0.05, p <  0.01).	Fluoxetine	154-157	cAMP responsive element binding protein 1	Mus musculus	63-67
34280458-9	2021	The protein ratios of p-ERK/ERK, p-CREB/CREB and ERK mRNA, and CREB mRNA expression decreased in the CUMS group (p <  0.01) and markedly increased in the FLU and BA groups (p <  0.05, p <  0.01).	baicalin	162-164	cAMP responsive element binding protein 1	Mus musculus	35-39
34280458-9	2021	The protein ratios of p-ERK/ERK, p-CREB/CREB and ERK mRNA, and CREB mRNA expression decreased in the CUMS group (p <  0.01) and markedly increased in the FLU and BA groups (p <  0.05, p <  0.01).	baicalin	162-164	cAMP responsive element binding protein 1	Mus musculus	40-44
34280458-9	2021	The protein ratios of p-ERK/ERK, p-CREB/CREB and ERK mRNA, and CREB mRNA expression decreased in the CUMS group (p <  0.01) and markedly increased in the FLU and BA groups (p <  0.05, p <  0.01).	baicalin	162-164	cAMP responsive element binding protein 1	Mus musculus	63-67
34280458-10	2021	The IOD value of the p-ERK and p-CREB in the CUMS group was decreased versus the CON group (p <  0.01), and these changes were improved via BA and FLU treatment (p <  0.05, p <  0.01).	baicalin	140-142	cAMP responsive element binding protein 1	Mus musculus	33-37
34685508-8	2021	Finally, Ex-4 pretreatment stimulated hippocampal expression of phosphorylated cyclic adenosine monophosphate (cAMP) response element-binding protein (p-CREB), a known target of GLP-1/GLP-1R signaling.	Adenosine	86-95	cAMP responsive element binding protein 1	Mus musculus	153-157
34280458-10	2021	The IOD value of the p-ERK and p-CREB in the CUMS group was decreased versus the CON group (p <  0.01), and these changes were improved via BA and FLU treatment (p <  0.05, p <  0.01).	Fluoxetine	147-150	cAMP responsive element binding protein 1	Mus musculus	33-37
34685508-8	2021	Finally, Ex-4 pretreatment stimulated hippocampal expression of phosphorylated cyclic adenosine monophosphate (cAMP) response element-binding protein (p-CREB), a known target of GLP-1/GLP-1R signaling.	Cyclic AMP	111-115	cAMP responsive element binding protein 1	Mus musculus	153-157
34280458-11	2021	This study indicated that BA can improve cognitive functions and has antidepressant effects in mice, which may be associated with activation of the BDNF/ERK/CREB signaling pathway in the hippocampus.	baicalin	26-28	cAMP responsive element binding protein 1	Mus musculus	157-161
34681303-4	2021	SHQA also suppressed alpha-MSH-induced cellular production of cyclic adenosine monophosphate (cAMP), which inhibited protein kinase A (PKA)-dependent cAMP-responsive element-binding protein (CREB) activation.	Adenosine	69-78	cAMP responsive element binding protein 1	Mus musculus	191-195
34681303-4	2021	SHQA also suppressed alpha-MSH-induced cellular production of cyclic adenosine monophosphate (cAMP), which inhibited protein kinase A (PKA)-dependent cAMP-responsive element-binding protein (CREB) activation.	Cyclic AMP	94-98	cAMP responsive element binding protein 1	Mus musculus	191-195
34681303-4	2021	SHQA also suppressed alpha-MSH-induced cellular production of cyclic adenosine monophosphate (cAMP), which inhibited protein kinase A (PKA)-dependent cAMP-responsive element-binding protein (CREB) activation.	Cyclic AMP	150-154	cAMP responsive element binding protein 1	Mus musculus	191-195
34545607-0	2022	Neuroprotective effect of Sumatriptan in Pentylenetetrazole-induced seizure is mediated through NMDA/Nitric oxide and CREB signaling pathway.	Sumatriptan	26-37	cAMP responsive element binding protein 1	Mus musculus	118-122
34545607-4	2022	OBJECTIVES: In the current study, we tried to investigate the possible interaction of sumatriptan with NMDA/NO and CREB signaling pathway in PTZ induced seizure.	Sumatriptan	86-97	cAMP responsive element binding protein 1	Mus musculus	115-119
34545607-10	2022	Furthermore, sumatriptan significantly inhibited the PTZ-induced mRNA expression of NR2A (P<0.0001), NR2B (P<0.05), and CREB (P<0.01).	Pentylenetetrazole	53-56	cAMP responsive element binding protein 1	Mus musculus	120-124
34545607-4	2022	OBJECTIVES: In the current study, we tried to investigate the possible interaction of sumatriptan with NMDA/NO and CREB signaling pathway in PTZ induced seizure.	Pentylenetetrazole	141-144	cAMP responsive element binding protein 1	Mus musculus	115-119
34545607-12	2022	CONCLUSION: Hence, current findings suggest that the anticonvulsant effect of sumatriptan was due to down regulation of NMDA/NO and CREB signaling pathway.	Sumatriptan	78-89	cAMP responsive element binding protein 1	Mus musculus	132-136
34545607-10	2022	Furthermore, sumatriptan significantly inhibited the PTZ-induced mRNA expression of NR2A (P<0.0001), NR2B (P<0.05), and CREB (P<0.01).	Sumatriptan	13-24	cAMP responsive element binding protein 1	Mus musculus	120-124
34588991-6	2021	Corresponding expression level changes of GPR81, P-PKA/PKA, P-CREB/cAMP-response element binding protein (CREB), and proteins related to lipid metabolism suggest that lactate could induce intramuscular triglyceride accumulation partly through the inhibition of the cAMP-PKA pathway.	Cyclic AMP	67-71	cAMP responsive element binding protein 1	Mus musculus	106-110
34469122-0	2021	Quercitrin Rapidly Alleviated Depression-like Behaviors in Lipopolysaccharide-Treated Mice: The Involvement of PI3K/AKT/NF-kappaB Signaling Suppression and CREB/BDNF Signaling Restoration in the Hippocampus.	quercitrin	0-10	cAMP responsive element binding protein 1	Mus musculus	156-160
34588991-6	2021	Corresponding expression level changes of GPR81, P-PKA/PKA, P-CREB/cAMP-response element binding protein (CREB), and proteins related to lipid metabolism suggest that lactate could induce intramuscular triglyceride accumulation partly through the inhibition of the cAMP-PKA pathway.	Lactic Acid	167-174	cAMP responsive element binding protein 1	Mus musculus	62-66
34588991-6	2021	Corresponding expression level changes of GPR81, P-PKA/PKA, P-CREB/cAMP-response element binding protein (CREB), and proteins related to lipid metabolism suggest that lactate could induce intramuscular triglyceride accumulation partly through the inhibition of the cAMP-PKA pathway.	Lactic Acid	167-174	cAMP responsive element binding protein 1	Mus musculus	106-110
34571935-0	2021	Schisandrae chinensis Fructus Extract Ameliorates Muscle Atrophy in Streptozotocin-Induced Diabetic Mice by Downregulation of the CREB-KLF15 and Autophagy-Lysosomal Pathways.	Streptozocin	68-82	cAMP responsive element binding protein 1	Mus musculus	130-134
34571935-10	2021	Our results suggest that SFe ameliorated muscle wasting in STZ-induced diabetic mice by decreasing protein degradation via downregulation of the CREB-KLF15-mediated UPS system and the p62/SQSTM1-mediated autophagy-lysosomal pathway.	Streptozocin	59-62	cAMP responsive element binding protein 1	Mus musculus	145-149
34119603-6	2021	Forced expression of VP16-CREB, a constitutively active mutant, rescued Nurr1 expression and showed prominent neuroprotection in MPTP-intoxicated mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	129-133	cAMP responsive element binding protein 1	Mus musculus	26-30
34314818-11	2021	Moreover, EAA also down-regulated MC1R, TRP-1/-2, tyrosinase expressions, and melanin synthesis by suppressing the cAMP-CREB-mediated MITF expression in B16F10 cells stimulated with alpha-MSH.	3-O-ethylascorbic acid	10-13	cAMP responsive element binding protein 1	Mus musculus	120-124
34314818-11	2021	Moreover, EAA also down-regulated MC1R, TRP-1/-2, tyrosinase expressions, and melanin synthesis by suppressing the cAMP-CREB-mediated MITF expression in B16F10 cells stimulated with alpha-MSH.	Cyclic AMP	115-119	cAMP responsive element binding protein 1	Mus musculus	120-124
34161892-9	2021	DOXY caused a marked increase in the hippocampal expression of phospho-CREB and GSH concentrations.	Doxycycline	0-4	cAMP responsive element binding protein 1	Mus musculus	71-75
34283253-9	2021	STZ mice showed high p-Tau levels, reduced p-CREB, and accumulation of beta-amyloid (Abeta) plaque in hippocampal areas and corpus callosum.	Streptozocin	0-3	cAMP responsive element binding protein 1	Mus musculus	45-49
34512242-0	2021	Effect of Electro-Acupuncture at ST36 and SP6 on the cAMP -CREB Pathway and mRNA Expression Profile in the Brainstem of Morphine Tolerant Mice.	Morphine	120-128	cAMP responsive element binding protein 1	Mus musculus	59-63
34512242-10	2021	Due to the well described relevance of cyclic adenosine monophosphate (cAMP), protein kinase A (PKA), extracellular regulated protein kinases (ERK), and cAMP response element-binding (CREB) in brainstem (BS) to analgesia tolerance, the cAMP-PKA/ERK-CREB signaling was deeply concerned in this study.	Cyclic AMP	236-240	cAMP responsive element binding protein 1	Mus musculus	249-253
34512242-12	2021	Similarly, western blot revealed the phosphorylation levels of PKA, ERK, and CREB were up-regulated in morphine tolerant mice, whereas the EA group showed a significantly reduced expression level instead.	Morphine	103-111	cAMP responsive element binding protein 1	Mus musculus	77-81
34512242-13	2021	This study observed an attenuating effect of the EA at ST36 and SP6 on morphine tolerance in mice, and suggested several potential biological targets by RNA-seq, which include the cAMP-PKA/ERK-CREB signaling pathway, strongly supporting a useful treatment for combatting the opioid epidemic, and opioid-tolerant patients.	Cyclic AMP	180-184	cAMP responsive element binding protein 1	Mus musculus	193-197
34432186-12	2022	Our finding revealed the improving effects of tPBM and EE on depressive and anxiety-like behaviors induced by noise stress, possibly by augmenting the BDNF/TrkB/CREB signaling pathway.	TPBM	46-50	cAMP responsive element binding protein 1	Mus musculus	161-165
34380377-0	2021	Ghrelin improves cognition via activation of the cAMP- CREB signalling pathway in depressed male C57BL/6J mice.	Cyclic AMP	49-53	cAMP responsive element binding protein 1	Mus musculus	55-59
34380377-2	2021	Ghrelin affects the level of Brain-derived nerve growth factor (BDNF) through the cAMP-CREB signalling pathway, and lower BDNF levels lead to cognitive decline.	Cyclic AMP	82-86	cAMP responsive element binding protein 1	Mus musculus	87-91
34380377-7	2021	Supplementation of ghrelin+(D-lys3))-GHRP-6 resulted in more significant positive changes in all comparison indexes than those of ghrelin alone.Conclusions: In the depression model, lower ghrelin causes hippocampal BDNF to decrease and results in cognitive decline via the cAMP-CREB signalling pathway.	(d-lys3))	27-36	cAMP responsive element binding protein 1	Mus musculus	278-282
34380377-7	2021	Supplementation of ghrelin+(D-lys3))-GHRP-6 resulted in more significant positive changes in all comparison indexes than those of ghrelin alone.Conclusions: In the depression model, lower ghrelin causes hippocampal BDNF to decrease and results in cognitive decline via the cAMP-CREB signalling pathway.	ghrp-	37-42	cAMP responsive element binding protein 1	Mus musculus	278-282
34380377-7	2021	Supplementation of ghrelin+(D-lys3))-GHRP-6 resulted in more significant positive changes in all comparison indexes than those of ghrelin alone.Conclusions: In the depression model, lower ghrelin causes hippocampal BDNF to decrease and results in cognitive decline via the cAMP-CREB signalling pathway.	Cyclic AMP	273-277	cAMP responsive element binding protein 1	Mus musculus	278-282
34175423-3	2021	The transcriptional factor cAMP response element binding protein (CREB), and deacetylases isozymes sirtuins 1 and 2 (SIRT-1 and SIRT-2) have a complex interplay and both play a role in the rewarding effects of ethanol.	Ethanol	210-217	cAMP responsive element binding protein 1	Mus musculus	27-64
34175423-3	2021	The transcriptional factor cAMP response element binding protein (CREB), and deacetylases isozymes sirtuins 1 and 2 (SIRT-1 and SIRT-2) have a complex interplay and both play a role in the rewarding effects of ethanol.	Ethanol	210-217	cAMP responsive element binding protein 1	Mus musculus	66-70
34175423-8	2021	VPA, ethanol and the combination of both inhibited pCREB and pCREB/CREB ratio in the NAc, suggesting that both reward stimuli can share similar patterns of CREB activation.	VALPROIC ACID	0-3	cAMP responsive element binding protein 1	Mus musculus	67-71
34175423-8	2021	VPA, ethanol and the combination of both inhibited pCREB and pCREB/CREB ratio in the NAc, suggesting that both reward stimuli can share similar patterns of CREB activation.	VALPROIC ACID	0-3	cAMP responsive element binding protein 1	Mus musculus	156-160
34175423-8	2021	VPA, ethanol and the combination of both inhibited pCREB and pCREB/CREB ratio in the NAc, suggesting that both reward stimuli can share similar patterns of CREB activation.	Ethanol	5-12	cAMP responsive element binding protein 1	Mus musculus	67-71
34175423-8	2021	VPA, ethanol and the combination of both inhibited pCREB and pCREB/CREB ratio in the NAc, suggesting that both reward stimuli can share similar patterns of CREB activation.	Ethanol	5-12	cAMP responsive element binding protein 1	Mus musculus	156-160
34175423-9	2021	However, we have also found that ethanol-induced increased CREB levels was prevented by VPA.	Ethanol	33-40	cAMP responsive element binding protein 1	Mus musculus	59-63
34175423-9	2021	However, we have also found that ethanol-induced increased CREB levels was prevented by VPA.	VALPROIC ACID	88-91	cAMP responsive element binding protein 1	Mus musculus	59-63
34119603-7	2021	Collectively, our results demonstrate that Nurr1 downregulation in the MPTP-induced PD mouse model is caused by CREB inactivation, which may provide a new target for neuroprotective therapy in PD.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	71-75	cAMP responsive element binding protein 1	Mus musculus	112-116
34175423-11	2021	Thus, exposure to running wheels prevented ethanol-rewarding effects and ethanol-induced increases in CREB in the NAc.	Ethanol	73-80	cAMP responsive element binding protein 1	Mus musculus	102-106
34175423-12	2021	The molecular alterations underlying CPP prevention may be related to a lower expression of CREB in the NAc of Ethanol-VPA compared to the respective Sedentary group, given the positive correlation between CPP and CREB levels in the Ethanol-Sedentary group.	Ethanol	111-118	cAMP responsive element binding protein 1	Mus musculus	92-96
34175423-12	2021	The molecular alterations underlying CPP prevention may be related to a lower expression of CREB in the NAc of Ethanol-VPA compared to the respective Sedentary group, given the positive correlation between CPP and CREB levels in the Ethanol-Sedentary group.	VALPROIC ACID	119-122	cAMP responsive element binding protein 1	Mus musculus	92-96
34175423-12	2021	The molecular alterations underlying CPP prevention may be related to a lower expression of CREB in the NAc of Ethanol-VPA compared to the respective Sedentary group, given the positive correlation between CPP and CREB levels in the Ethanol-Sedentary group.	Ethanol	111-118	cAMP responsive element binding protein 1	Mus musculus	214-218
34175423-12	2021	The molecular alterations underlying CPP prevention may be related to a lower expression of CREB in the NAc of Ethanol-VPA compared to the respective Sedentary group, given the positive correlation between CPP and CREB levels in the Ethanol-Sedentary group.	VALPROIC ACID	119-122	cAMP responsive element binding protein 1	Mus musculus	214-218
34348143-6	2021	Finally, we show that varied upregulation of hippocampal miR-466f-3p results from randomized phosphorylation of hippocampal cyclic AMP (cAMP)-response element binding (CREB) in individuals.	Cyclic AMP	124-134	cAMP responsive element binding protein 1	Mus musculus	168-172
34348143-6	2021	Finally, we show that varied upregulation of hippocampal miR-466f-3p results from randomized phosphorylation of hippocampal cyclic AMP (cAMP)-response element binding (CREB) in individuals.	Cyclic AMP	136-140	cAMP responsive element binding protein 1	Mus musculus	168-172
34087694-0	2021	Baicalein alleviates depression-like behavior in rotenone- induced Parkinson"s disease model in mice through activating the BDNF/TrkB/CREB pathway.	baicalein	0-9	cAMP responsive element binding protein 1	Mus musculus	134-138
34087694-10	2021	Moreover, we found that baicalein treatment could remarkably protect the synaptic plasticity and activate the BDNF/TrkB/CREB pathway in the PD-related depression mice model.	baicalein	24-33	cAMP responsive element binding protein 1	Mus musculus	120-124
34333859-9	2021	CONCLUSION: MiR-199a-5p can target WNT2 to enhance the development of depression through regulation of the CREB/BDNF signaling.	-199a-5p	15-23	cAMP responsive element binding protein 1	Mus musculus	107-111
34329394-13	2021	CONCLUSIONS: Our data show that ANP and BNP act in a non-redundant fashion to maintain myocardial cGMP levels to regulate cardiomyocyte p38 MAPK and CREB activity.	Cyclic GMP	98-102	cAMP responsive element binding protein 1	Mus musculus	149-153
34329394-16	2021	We discovered that ANP and BNP act in a non-redundant fashion to maintain myocardial cGMP levels and uncovered a unique role for these peptides in regulating cardiomyocyte p38 MAPK and CREB signaling through a cGMP-PKG1 pathway.	Cyclic GMP	210-214	cAMP responsive element binding protein 1	Mus musculus	185-189
34393775-8	2021	In scopolamine-treated mice, PA increased the concentrations of neurotransmitters in the hippocampus, activated the brain-derived neurotrophic factor (BDNF)/extracellular signal-regulated kinase (ERK)/cAMP response element binding protein (CREB) signaling pathway, and increased the expression of p90 ribosomal S6 kinase (p90RSK) and postsynaptic density (PSD)95 proteins.	Protactinium	29-31	cAMP responsive element binding protein 1	Mus musculus	240-244
34393775-8	2021	In scopolamine-treated mice, PA increased the concentrations of neurotransmitters in the hippocampus, activated the brain-derived neurotrophic factor (BDNF)/extracellular signal-regulated kinase (ERK)/cAMP response element binding protein (CREB) signaling pathway, and increased the expression of p90 ribosomal S6 kinase (p90RSK) and postsynaptic density (PSD)95 proteins.	Cyclic AMP	201-205	cAMP responsive element binding protein 1	Mus musculus	240-244
34060828-8	2021	Further investigation from both in vivo and in vitro experiments indicated that the antidepressant mechanism of theacrine was associated with promoting adult hippocampal neurogenesis, via the modulation of the phosphodiesterase-4 (PDE4)/cyclic adenosine monophosphate (cAMP)/cAMP response-element binding (CREB)/brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) pathway.	1,3,7,9-tetramethyluric acid	112-121	cAMP responsive element binding protein 1	Mus musculus	306-310
34060828-8	2021	Further investigation from both in vivo and in vitro experiments indicated that the antidepressant mechanism of theacrine was associated with promoting adult hippocampal neurogenesis, via the modulation of the phosphodiesterase-4 (PDE4)/cyclic adenosine monophosphate (cAMP)/cAMP response-element binding (CREB)/brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) pathway.	Adenosine	244-253	cAMP responsive element binding protein 1	Mus musculus	306-310
34060828-8	2021	Further investigation from both in vivo and in vitro experiments indicated that the antidepressant mechanism of theacrine was associated with promoting adult hippocampal neurogenesis, via the modulation of the phosphodiesterase-4 (PDE4)/cyclic adenosine monophosphate (cAMP)/cAMP response-element binding (CREB)/brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) pathway.	Cyclic AMP	269-273	cAMP responsive element binding protein 1	Mus musculus	306-310
34060828-8	2021	Further investigation from both in vivo and in vitro experiments indicated that the antidepressant mechanism of theacrine was associated with promoting adult hippocampal neurogenesis, via the modulation of the phosphodiesterase-4 (PDE4)/cyclic adenosine monophosphate (cAMP)/cAMP response-element binding (CREB)/brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) pathway.	Cyclic AMP	275-279	cAMP responsive element binding protein 1	Mus musculus	306-310
34257818-0	2021	Pentoxifylline Enhances Antioxidative Capability and Promotes Mitochondrial Biogenesis in D-Galactose-Induced Aging Mice by Increasing Nrf2 and PGC-1alpha through the cAMP-CREB Pathway.	Pentoxifylline	0-14	cAMP responsive element binding protein 1	Mus musculus	172-176
34257818-0	2021	Pentoxifylline Enhances Antioxidative Capability and Promotes Mitochondrial Biogenesis in D-Galactose-Induced Aging Mice by Increasing Nrf2 and PGC-1alpha through the cAMP-CREB Pathway.	Cyclic AMP	167-171	cAMP responsive element binding protein 1	Mus musculus	172-176
34142658-7	2021	Collectively, this study provides direct proof for an essential role of the CRTC-CREB activation in promoting the malignant phenotypes of LKB1-null lung cancer and proposes the CRTC-CREB interaction interface as a novel therapeutic target.	crtc	76-80	cAMP responsive element binding protein 1	Mus musculus	81-85
34142658-7	2021	Collectively, this study provides direct proof for an essential role of the CRTC-CREB activation in promoting the malignant phenotypes of LKB1-null lung cancer and proposes the CRTC-CREB interaction interface as a novel therapeutic target.	crtc	76-80	cAMP responsive element binding protein 1	Mus musculus	182-186
34142658-7	2021	Collectively, this study provides direct proof for an essential role of the CRTC-CREB activation in promoting the malignant phenotypes of LKB1-null lung cancer and proposes the CRTC-CREB interaction interface as a novel therapeutic target.	crtc	177-181	cAMP responsive element binding protein 1	Mus musculus	81-85
34142658-7	2021	Collectively, this study provides direct proof for an essential role of the CRTC-CREB activation in promoting the malignant phenotypes of LKB1-null lung cancer and proposes the CRTC-CREB interaction interface as a novel therapeutic target.	crtc	177-181	cAMP responsive element binding protein 1	Mus musculus	182-186
34512242-0	2021	Effect of Electro-Acupuncture at ST36 and SP6 on the cAMP -CREB Pathway and mRNA Expression Profile in the Brainstem of Morphine Tolerant Mice.	Cyclic AMP	53-57	cAMP responsive element binding protein 1	Mus musculus	59-63
34361022-5	2021	We also clarify that the GABA-mediated antimelanogenic properties were related to the direct inhibition of microphthalmia-associated transcription factor (MITF) and tyrosinase expression by inhibiting cyclic adenosine monophosphate (cAMP) and cAMP response element-binding protein (CREB).	gamma-Aminobutyric Acid	25-29	cAMP responsive element binding protein 1	Mus musculus	243-280
34361022-5	2021	We also clarify that the GABA-mediated antimelanogenic properties were related to the direct inhibition of microphthalmia-associated transcription factor (MITF) and tyrosinase expression by inhibiting cyclic adenosine monophosphate (cAMP) and cAMP response element-binding protein (CREB).	gamma-Aminobutyric Acid	25-29	cAMP responsive element binding protein 1	Mus musculus	282-286
34321593-1	2021	Homophily for membrane-associated PDE11A-cAMP-CREB signaling in CA1 of hippocampus dictates mutual social preference in male and female mice.	Cyclic AMP	41-45	cAMP responsive element binding protein 1	Mus musculus	46-50
34321593-8	2021	Stereotactic delivery of an isolated PDE11A GAF-B domain to the mouse hippocampus revealed the membrane-associated pool of PDE11A-cAMP-CREB signaling specifically within the CA1 subfield of hippocampus is most critical for regulating social preference.	Cyclic AMP	130-134	cAMP responsive element binding protein 1	Mus musculus	135-139
34400899-7	2021	AYC-P-E inhibited melanogenesis in alpha-MSH-treated B16F10 cells, accompanied by decreased mRNA and protein expression of melanin biosynthesis inducers, including cyclic AMP response element-binding protein (CREB), tyrosinase, microphthalmia-associated transcription factor (MITF), tyrosinase related protein-1 (TRP-1), and TRP-2.	ayc-p-e	0-7	cAMP responsive element binding protein 1	Mus musculus	164-207
34400899-7	2021	AYC-P-E inhibited melanogenesis in alpha-MSH-treated B16F10 cells, accompanied by decreased mRNA and protein expression of melanin biosynthesis inducers, including cyclic AMP response element-binding protein (CREB), tyrosinase, microphthalmia-associated transcription factor (MITF), tyrosinase related protein-1 (TRP-1), and TRP-2.	ayc-p-e	0-7	cAMP responsive element binding protein 1	Mus musculus	209-213
34400899-7	2021	AYC-P-E inhibited melanogenesis in alpha-MSH-treated B16F10 cells, accompanied by decreased mRNA and protein expression of melanin biosynthesis inducers, including cyclic AMP response element-binding protein (CREB), tyrosinase, microphthalmia-associated transcription factor (MITF), tyrosinase related protein-1 (TRP-1), and TRP-2.	Melanins	123-130	cAMP responsive element binding protein 1	Mus musculus	164-207
34400899-7	2021	AYC-P-E inhibited melanogenesis in alpha-MSH-treated B16F10 cells, accompanied by decreased mRNA and protein expression of melanin biosynthesis inducers, including cyclic AMP response element-binding protein (CREB), tyrosinase, microphthalmia-associated transcription factor (MITF), tyrosinase related protein-1 (TRP-1), and TRP-2.	Melanins	123-130	cAMP responsive element binding protein 1	Mus musculus	209-213
34135002-7	2021	Our data demonstrated that depleting PDE7A promoted, whereas forcing PDE7A suppressed the activation of cAMP/CREB signaling as well as cell proliferation and neuronal differentiation of NSCs.	Cyclic AMP	104-108	cAMP responsive element binding protein 1	Mus musculus	109-113
34356311-6	2021	Furthermore, compound 2 downregulated the protein kinase A (PKA)/cAMP response element-binding protein (CREB) and mitogen-activated protein kinase (MAPK) signaling pathways, which led to a reduction in microphthalmia-associated transcription factor (MITF) expression, and decreased tyrosinase, tyrosinase related protein 1 (TRP1), and TRP2 expression, resulting in anti-melanogenesis activity.	Cyclic AMP	65-69	cAMP responsive element binding protein 1	Mus musculus	104-108
34171357-2	2021	CREB is activated through phosphorylation of an evolutionarily conserved Ser residue (S133) within its intrinsically disordered kinase-inducible domain (KID).	Serine	73-76	cAMP responsive element binding protein 1	Mus musculus	0-4
34211563-9	2021	In addition, HPTQ restored DCD-induced decline of p-CREB, BDNF, TrkB, and p-Akt in the hippocampus.	hptq	13-17	cAMP responsive element binding protein 1	Mus musculus	52-56
34073796-2	2021	The dysfunctions of the cognitive and memory battery are closely related to inhibitions of neurotrophic factor (BDNF) and brain-derived cAMP response element-binding protein (CREB) to associate with the cholinergic system and long-term potentiation.	Cyclic AMP	136-140	cAMP responsive element binding protein 1	Mus musculus	175-179
34073796-9	2021	In conclusion, the central administration of ampelopsin A contributes to increasing neurocognitive and neuroprotective effects on intrinsic neuronal excitability and behaviors, partly through elevated BDNF/CREB-related signaling.	Ampelopsin A	45-57	cAMP responsive element binding protein 1	Mus musculus	206-210