PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
28316141-10	2017	Dasatinib markedly inhibited tyrosine phosphorylation of p130 Crk-associated substrate (p130cas), paxillin and vinculin.	Dasatinib	0-9	vinculin	Mus musculus	111-119
28126411-8	2017	Endocytosis-related genes were selected for qPCR analysis, with many found to be significantly changed after PFOA treatment, including epidermal growth factor receptor pathway substrate 8 (Eps8), Eps15, cortactin, cofilin, espin, vinculin, and zyxin.	perfluorooctanoic acid	109-113	vinculin	Mus musculus	230-238
28115390-7	2017	In subsequent coimmunostaining studies, Myo9b was colocalized with filamentous actin, cortactin, vinculin, and Tks5 in the podosomes of phorbol 12,13-dibutyrate-treated macrophages, indicating that Myo9b participates in podosome formation.	phorbol	136-143	vinculin	Mus musculus	97-105
28115390-7	2017	In subsequent coimmunostaining studies, Myo9b was colocalized with filamentous actin, cortactin, vinculin, and Tks5 in the podosomes of phorbol 12,13-dibutyrate-treated macrophages, indicating that Myo9b participates in podosome formation.	13-dibutyrate	147-160	vinculin	Mus musculus	97-105
23872053-4	2013	Vinculin is recruited early in IS formation, in parallel to a local phosphatidylinositol (4,5)-bisphosphate wave, and requires spleen tyrosine kinase activity.	Phosphatidylinositol 4,5-Diphosphate	68-107	vinculin	Mus musculus	0-8
28089450-0	2017	A Structural Model for Vinculin Insertion into PIP2-Containing Membranes and the Effect of Insertion on Vinculin Activation and Localization.	Phosphatidylinositol 4,5-Diphosphate	47-51	vinculin	Mus musculus	23-31
28089450-2	2017	While vinculin binds to a number of cytoskeletal proteins, it can also associate with phosphatidylinositol 4,5-bisphosphate (PIP2) to drive membrane association.	Phosphatidylinositol 4,5-Diphosphate	86-123	vinculin	Mus musculus	6-14
28089450-2	2017	While vinculin binds to a number of cytoskeletal proteins, it can also associate with phosphatidylinositol 4,5-bisphosphate (PIP2) to drive membrane association.	Phosphatidylinositol 4,5-Diphosphate	125-129	vinculin	Mus musculus	6-14
28089450-3	2017	To generate a structural model for PIP2-dependent interaction of vinculin with the lipid bilayer, we conducted lipid-association, nuclear magnetic resonance, and computational modeling experiments.	Phosphatidylinositol 4,5-Diphosphate	35-39	vinculin	Mus musculus	65-73
28089450-4	2017	We find that two basic patches on the vinculin tail drive membrane association: the basic collar specifically recognizes PIP2, while the basic ladder drives association with the lipid bilayer.	Phosphatidylinositol 4,5-Diphosphate	121-125	vinculin	Mus musculus	38-46
28089450-6	2017	Results from these analyses indicate that PIP2 binding is not required for localization of vinculin to FAs or FA strengthening, but is required for vinculin activation and turnover at FAs to promote its association with the force transduction FA nanodomain.	Phosphatidylinositol 4,5-Diphosphate	42-46	vinculin	Mus musculus	148-156
27524023-5	2016	Also, MC3T3-E1 cells on Ca-P-Ti expressed larger amount of vinculin, a focal adhesion protein, than those on other substrates, probably resulting in larger cell size as well as greater cell proliferation on Ca-P-Ti than those on other substrates.	ca-p	24-28	vinculin	Mus musculus	59-67
27524023-5	2016	Also, MC3T3-E1 cells on Ca-P-Ti expressed larger amount of vinculin, a focal adhesion protein, than those on other substrates, probably resulting in larger cell size as well as greater cell proliferation on Ca-P-Ti than those on other substrates.	ca-p	207-211	vinculin	Mus musculus	59-67
26963473-8	2016	Real-time PCR identified significant DHT-dependent changes in the concentrations of mRNAs encoded by genes implicated in the regulation of the cell cycle (Wee1, Ccnd1, Rb1) and stromal-epithelial interactions (Wnt4, Wnt5a, Wnt7a, Cdh1, Vcl, Igf1, Prl8, Prlr) as well as a striking effect on the number of endometrial glands.	Dihydrotestosterone	37-40	vinculin	Mus musculus	236-239
26370460-6	2015	Treatments with silymarin (5, 10, 20 mug/mL) did not significantly affect sperm motility under NG conditions, but decreased the HG-enhanced motility, VAP, and VCL at 120 min (p < 0.05).	Silymarin	16-25	vinculin	Mus musculus	159-162
25834823-4	2015	Phloretin allayed RANKL stimulated formation of actin podosomes with the concomitant retardation of the vinculin activation.	Phloretin	0-9	vinculin	Mus musculus	104-112
25834823-5	2015	Oral administration of phloretin suppressed the induction of femoral gelsolin and vinculin in OVX mice.	Phloretin	23-32	vinculin	Mus musculus	82-90
25488920-3	2014	Phosphatidylinositol 4,5-bisphosphate (PIP2) affects the functions of many targets, including vinculin.	Phosphatidylinositol 4,5-Diphosphate	0-37	vinculin	Mus musculus	94-102
25488920-3	2014	Phosphatidylinositol 4,5-bisphosphate (PIP2) affects the functions of many targets, including vinculin.	Phosphatidylinositol 4,5-Diphosphate	39-43	vinculin	Mus musculus	94-102
25488920-4	2014	Here we report the crystal structure of vinculin in complex with PIP2, which revealed that PIP2 binding alters vinculin structure to direct higher-order oligomerization and suggests that PIP2 and F-actin binding to vinculin are mutually permissive.	Phosphatidylinositol 4,5-Diphosphate	65-69	vinculin	Mus musculus	40-48
25488920-4	2014	Here we report the crystal structure of vinculin in complex with PIP2, which revealed that PIP2 binding alters vinculin structure to direct higher-order oligomerization and suggests that PIP2 and F-actin binding to vinculin are mutually permissive.	Phosphatidylinositol 4,5-Diphosphate	65-69	vinculin	Mus musculus	111-119
25488920-4	2014	Here we report the crystal structure of vinculin in complex with PIP2, which revealed that PIP2 binding alters vinculin structure to direct higher-order oligomerization and suggests that PIP2 and F-actin binding to vinculin are mutually permissive.	Phosphatidylinositol 4,5-Diphosphate	65-69	vinculin	Mus musculus	111-119
25488920-4	2014	Here we report the crystal structure of vinculin in complex with PIP2, which revealed that PIP2 binding alters vinculin structure to direct higher-order oligomerization and suggests that PIP2 and F-actin binding to vinculin are mutually permissive.	Phosphatidylinositol 4,5-Diphosphate	91-95	vinculin	Mus musculus	40-48
25488920-4	2014	Here we report the crystal structure of vinculin in complex with PIP2, which revealed that PIP2 binding alters vinculin structure to direct higher-order oligomerization and suggests that PIP2 and F-actin binding to vinculin are mutually permissive.	Phosphatidylinositol 4,5-Diphosphate	91-95	vinculin	Mus musculus	111-119
25488920-4	2014	Here we report the crystal structure of vinculin in complex with PIP2, which revealed that PIP2 binding alters vinculin structure to direct higher-order oligomerization and suggests that PIP2 and F-actin binding to vinculin are mutually permissive.	Phosphatidylinositol 4,5-Diphosphate	91-95	vinculin	Mus musculus	111-119
25488920-5	2014	Forced expression of PIP2-binding-deficient mutants of vinculin in vinculin-null mouse embryonic fibroblasts revealed that PIP2 binding is necessary for maintaining optimal FAs, for organization of actin stress fibers, and for cell migration and spreading.	Phosphatidylinositol 4,5-Diphosphate	21-25	vinculin	Mus musculus	55-63
25488920-5	2014	Forced expression of PIP2-binding-deficient mutants of vinculin in vinculin-null mouse embryonic fibroblasts revealed that PIP2 binding is necessary for maintaining optimal FAs, for organization of actin stress fibers, and for cell migration and spreading.	Phosphatidylinositol 4,5-Diphosphate	21-25	vinculin	Mus musculus	67-75
25488920-5	2014	Forced expression of PIP2-binding-deficient mutants of vinculin in vinculin-null mouse embryonic fibroblasts revealed that PIP2 binding is necessary for maintaining optimal FAs, for organization of actin stress fibers, and for cell migration and spreading.	Phosphatidylinositol 4,5-Diphosphate	123-127	vinculin	Mus musculus	55-63
25488920-6	2014	Finally, photobleaching experiments indicated that PIP2 binding is required for the control of vinculin dynamics and turnover in FAs.	Phosphatidylinositol 4,5-Diphosphate	51-55	vinculin	Mus musculus	95-103
25488920-7	2014	Thus, through oligomerization, PIP2 directs a transient vinculin sequestration at FAs that is necessary for proper FA function.	Phosphatidylinositol 4,5-Diphosphate	31-35	vinculin	Mus musculus	56-64
27358375-7	2016	Moreover, cells cultured on three-dimensional graphene/polydimethylsiloxane composite generated less ROS than the control at culture times of 3-6 h. The results of immunofluorescence staining demonstrated that fibroblast cells expressed adhesion protein (vinculin) and adhered well on three-dimensional graphene/polydimethylsiloxane surface.	Graphite	46-54	vinculin	Mus musculus	255-263
27358375-7	2016	Moreover, cells cultured on three-dimensional graphene/polydimethylsiloxane composite generated less ROS than the control at culture times of 3-6 h. The results of immunofluorescence staining demonstrated that fibroblast cells expressed adhesion protein (vinculin) and adhered well on three-dimensional graphene/polydimethylsiloxane surface.	baysilon	55-75	vinculin	Mus musculus	255-263
20213106-3	2010	Cells expressing beta(1)DN had reduced vinculin localization to focal contacts but no change in intracellular actin organization.	beta(1)dn	17-26	vinculin	Mus musculus	39-47
22759972-9	2012	Phosphorylation of vinculin was significantly enhanced in sgk1(-/-)platelets and was significantly reduced following treatment of platelets with Ca(2+) chelator BAPTA.	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	161-166	vinculin	Mus musculus	19-27
21273052-7	2011	Vinculin molecules expressed in cells cultured on the non-porous silica films showed many clear focal adhesions, whereas focal contacts were insufficiently formed in cells cultured on macroporous films.	Silicon Dioxide	65-71	vinculin	Mus musculus	0-8
20841379-0	2010	Rac controls PIP5K localisation and PtdIns(4,5)P2 synthesis, which modulates vinculin localisation and neurite dynamics.	Phosphatidylinositol 4,5-Diphosphate	36-49	vinculin	Mus musculus	77-85
20841379-8	2010	To clarify how increased levels of PtdIns(4,5)P2 induce neurite retraction, we show that mutants of vinculin that are unable to interact with PtdIns(4,5)P2, attenuate PIP5K- and LPA-induced neurite retraction.	Phosphatidylinositol 4,5-Diphosphate	35-48	vinculin	Mus musculus	100-108
20841379-9	2010	Our findings support a role for PtdIns(4,5)P2 synthesis in the regulation of vinculin localisation at focal complexes and ultimately in the regulation of neurite dynamics.	Phosphatidylinositol 4,5-Diphosphate	32-45	vinculin	Mus musculus	77-85
19580787-0	2009	Tyrosine phosphorylation of vinexin in v-Src-transformed cells attenuates the affinity for vinculin.	Tyrosine	0-8	vinculin	Mus musculus	91-99
20039876-11	2010	In the presence of blebbistatin, stellate cells became smaller, acquired a dendritic morphology and had less myosin IIA-containing stress fibres and vinculin-containing focal adhesions.	blebbistatin	19-31	vinculin	Mus musculus	149-157
19628583-10	2009	In parallel, caveolin-1, FAK, vinculin, and paxillin are phosphorylated on Tyr residues apparently by GnRH-activated c-Src.	Tyrosine	75-78	vinculin	Mus musculus	30-38
19580787-5	2009	In conclusion, vinexin alpha is tyrosine phosphorylated in v-Src-transformed cells, and this tyrosine phosphorylation of vinexin alpha attenuates the association of vinexin alpha with vinculin.	Tyrosine	32-40	vinculin	Mus musculus	184-192
19580787-5	2009	In conclusion, vinexin alpha is tyrosine phosphorylated in v-Src-transformed cells, and this tyrosine phosphorylation of vinexin alpha attenuates the association of vinexin alpha with vinculin.	Tyrosine	93-101	vinculin	Mus musculus	184-192
19542491-0	2009	Abl knockout differentially affects p130 Crk-associated substrate, vinculin, and paxillin in blood vessels of mice.	lauric acid	0-3	vinculin	Mus musculus	67-75
19542491-7	2009	The expression of vinculin and paxillin at protein and messenger levels was lower in arterial vessels from Abl knockout mice.	lauric acid	107-110	vinculin	Mus musculus	18-26
19542491-9	2009	These results indicate that Abl differentially regulates Crk-associated substrate, vinculin, and paxillin in arterial vessels.	lauric acid	28-31	vinculin	Mus musculus	83-91
10487892-8	1999	The metal salt order of toxicity from the highest was K(2)Cr(2)O(7), AgNO(3), VCl(3), SbCl(3), CuCl(2), CoCl(2), NiCl(2), ZnCl(2), Cr(NO(3))(3), FeCl(3), TiCl(4), and Al(NO(3))(3).	metal salt	4-14	vinculin	Mus musculus	78-81
17307336-5	2007	Removal of LPA results in slow retraction with loss of vinculin-rich adhesion complexes and prolonged activation of RhoA.	lysophosphatidic acid	11-14	vinculin	Mus musculus	55-63
11858705-8	2001	Sequence comparisons with other actin- and phosphoinositide-binding proteins (vinculin, ActA, MARCKS) suggested that the carboxyl-terminal segment of MBP could form an amphipathic alpha helix and was the phosphoinositide binding site.	Phosphatidylinositols	43-59	vinculin	Mus musculus	78-86
16584805-5	2006	Phosphatidylinositol 4,5-bisphosphate (PIP2) is thought to play a role in vinculin activation by relieving an intramolecular association between the vinculin head (Vh) and tail (Vt) that masks the ligand binding sites in Vh and Vt. To investigate the role of the vinculin/PIP2 interaction in FA dynamics, we used a vinculin mutant lacking the C-terminal arm (residues 1053-1066) and referred to as the deltaC mutation.	Phosphatidylinositol 4,5-Diphosphate	0-37	vinculin	Mus musculus	74-82
16584805-5	2006	Phosphatidylinositol 4,5-bisphosphate (PIP2) is thought to play a role in vinculin activation by relieving an intramolecular association between the vinculin head (Vh) and tail (Vt) that masks the ligand binding sites in Vh and Vt. To investigate the role of the vinculin/PIP2 interaction in FA dynamics, we used a vinculin mutant lacking the C-terminal arm (residues 1053-1066) and referred to as the deltaC mutation.	Phosphatidylinositol 4,5-Diphosphate	0-37	vinculin	Mus musculus	149-157
16584805-5	2006	Phosphatidylinositol 4,5-bisphosphate (PIP2) is thought to play a role in vinculin activation by relieving an intramolecular association between the vinculin head (Vh) and tail (Vt) that masks the ligand binding sites in Vh and Vt. To investigate the role of the vinculin/PIP2 interaction in FA dynamics, we used a vinculin mutant lacking the C-terminal arm (residues 1053-1066) and referred to as the deltaC mutation.	Phosphatidylinositol 4,5-Diphosphate	0-37	vinculin	Mus musculus	149-157
16584805-5	2006	Phosphatidylinositol 4,5-bisphosphate (PIP2) is thought to play a role in vinculin activation by relieving an intramolecular association between the vinculin head (Vh) and tail (Vt) that masks the ligand binding sites in Vh and Vt. To investigate the role of the vinculin/PIP2 interaction in FA dynamics, we used a vinculin mutant lacking the C-terminal arm (residues 1053-1066) and referred to as the deltaC mutation.	Phosphatidylinositol 4,5-Diphosphate	0-37	vinculin	Mus musculus	149-157
16584805-5	2006	Phosphatidylinositol 4,5-bisphosphate (PIP2) is thought to play a role in vinculin activation by relieving an intramolecular association between the vinculin head (Vh) and tail (Vt) that masks the ligand binding sites in Vh and Vt. To investigate the role of the vinculin/PIP2 interaction in FA dynamics, we used a vinculin mutant lacking the C-terminal arm (residues 1053-1066) and referred to as the deltaC mutation.	Phosphatidylinositol 4,5-Diphosphate	39-43	vinculin	Mus musculus	74-82
16584805-5	2006	Phosphatidylinositol 4,5-bisphosphate (PIP2) is thought to play a role in vinculin activation by relieving an intramolecular association between the vinculin head (Vh) and tail (Vt) that masks the ligand binding sites in Vh and Vt. To investigate the role of the vinculin/PIP2 interaction in FA dynamics, we used a vinculin mutant lacking the C-terminal arm (residues 1053-1066) and referred to as the deltaC mutation.	Phosphatidylinositol 4,5-Diphosphate	39-43	vinculin	Mus musculus	149-157
16584805-5	2006	Phosphatidylinositol 4,5-bisphosphate (PIP2) is thought to play a role in vinculin activation by relieving an intramolecular association between the vinculin head (Vh) and tail (Vt) that masks the ligand binding sites in Vh and Vt. To investigate the role of the vinculin/PIP2 interaction in FA dynamics, we used a vinculin mutant lacking the C-terminal arm (residues 1053-1066) and referred to as the deltaC mutation.	Phosphatidylinositol 4,5-Diphosphate	39-43	vinculin	Mus musculus	149-157
16584805-5	2006	Phosphatidylinositol 4,5-bisphosphate (PIP2) is thought to play a role in vinculin activation by relieving an intramolecular association between the vinculin head (Vh) and tail (Vt) that masks the ligand binding sites in Vh and Vt. To investigate the role of the vinculin/PIP2 interaction in FA dynamics, we used a vinculin mutant lacking the C-terminal arm (residues 1053-1066) and referred to as the deltaC mutation.	Phosphatidylinositol 4,5-Diphosphate	39-43	vinculin	Mus musculus	149-157
16584805-5	2006	Phosphatidylinositol 4,5-bisphosphate (PIP2) is thought to play a role in vinculin activation by relieving an intramolecular association between the vinculin head (Vh) and tail (Vt) that masks the ligand binding sites in Vh and Vt. To investigate the role of the vinculin/PIP2 interaction in FA dynamics, we used a vinculin mutant lacking the C-terminal arm (residues 1053-1066) and referred to as the deltaC mutation.	Phosphatidylinositol 4,5-Diphosphate	272-276	vinculin	Mus musculus	74-82
16584805-5	2006	Phosphatidylinositol 4,5-bisphosphate (PIP2) is thought to play a role in vinculin activation by relieving an intramolecular association between the vinculin head (Vh) and tail (Vt) that masks the ligand binding sites in Vh and Vt. To investigate the role of the vinculin/PIP2 interaction in FA dynamics, we used a vinculin mutant lacking the C-terminal arm (residues 1053-1066) and referred to as the deltaC mutation.	Phosphatidylinositol 4,5-Diphosphate	272-276	vinculin	Mus musculus	149-157
16584805-5	2006	Phosphatidylinositol 4,5-bisphosphate (PIP2) is thought to play a role in vinculin activation by relieving an intramolecular association between the vinculin head (Vh) and tail (Vt) that masks the ligand binding sites in Vh and Vt. To investigate the role of the vinculin/PIP2 interaction in FA dynamics, we used a vinculin mutant lacking the C-terminal arm (residues 1053-1066) and referred to as the deltaC mutation.	Phosphatidylinositol 4,5-Diphosphate	272-276	vinculin	Mus musculus	149-157
16584805-5	2006	Phosphatidylinositol 4,5-bisphosphate (PIP2) is thought to play a role in vinculin activation by relieving an intramolecular association between the vinculin head (Vh) and tail (Vt) that masks the ligand binding sites in Vh and Vt. To investigate the role of the vinculin/PIP2 interaction in FA dynamics, we used a vinculin mutant lacking the C-terminal arm (residues 1053-1066) and referred to as the deltaC mutation.	Phosphatidylinositol 4,5-Diphosphate	272-276	vinculin	Mus musculus	149-157
16371343-10	2005	Addition of Y-27632 to vinculin-null outgrowth cultures further stimulates migration an additional 2-fold, supporting the conclusion that Rho/ROCK and vinculin regulate parietal endoderm outgrowth by distinct pathways.	Y 27632	12-19	vinculin	Mus musculus	23-31
16371343-10	2005	Addition of Y-27632 to vinculin-null outgrowth cultures further stimulates migration an additional 2-fold, supporting the conclusion that Rho/ROCK and vinculin regulate parietal endoderm outgrowth by distinct pathways.	Y 27632	12-19	vinculin	Mus musculus	151-159
15261162-3	2004	Immunofluorescence staining for the integrin subunits alphav and beta1 and the focal contact protein vinculin revealed that cells growing on gold and platinum expressed many focal contacts.	Platinum	150-158	vinculin	Mus musculus	101-109
10429657-7	1999	bFGF induced actin reorganization and vinculin assembly in the focal adhesion plaque, both of which were inhibited by SB203580 but not by PD98059.	SB 203580	118-126	vinculin	Mus musculus	38-46
9660809-7	1998	The actin cytoskeleton and cellular localization of vinculin are disrupted by replacement of tyrosine 1251.	Tyrosine	93-101	vinculin	Mus musculus	52-60
9885244-6	1999	The interaction between vinexin and vinculin was mediated by two SH3 domains of vinexin and the proline-rich region of vinculin.	Proline	96-103	vinculin	Mus musculus	36-44
9885244-6	1999	The interaction between vinexin and vinculin was mediated by two SH3 domains of vinexin and the proline-rich region of vinculin.	Proline	96-103	vinculin	Mus musculus	119-127
8601420-6	1996	Formation of focal contacts along discontinuities in the substratum was accompanied by the phosphorylation of tyrosine colocalized with F-actin and vinculin.	Tyrosine	110-118	vinculin	Mus musculus	148-156
8928811-5	1996	After 8 h of TPA exposure, actin filaments reassembled and vinculin again localized to the cell periphery.	Tetradecanoylphorbol Acetate	13-16	vinculin	Mus musculus	59-67
8928811-8	1996	Both vinculin and talin concentrations increased with prolonged TPA treatment.	Tetradecanoylphorbol Acetate	64-67	vinculin	Mus musculus	5-13
9281437-6	1997	These antisense oligonucleotides suppressed vinculin protein expression at 43.5+/-26.8% and 48.7+/-20.9% when compared to myocytes that were not treated.	Oligonucleotides	16-32	vinculin	Mus musculus	44-52
9118237-2	1996	We found that all microtubule-disrupting drugs including colcemid and vinblastine rapidly and reversibly induce the formation of actin stress fibers and focal adhesions containing vinculin, accompanied by activated cell motility in serum-starved Balb/c 3T3 cells.	Vinblastine	70-81	vinculin	Mus musculus	180-188
7593207-7	1995	The increase in vinculin localization to focal adhesions appeared to be a post-transcriptional process, since 12(S)-HETE treatment did not alter the overall protein level of vinculin in tumor cells, but resulted in a specific enrichment of vinculin to focal adhesions.	Hydroxyeicosatetraenoic Acids	114-120	vinculin	Mus musculus	16-24
8852373-8	1996	The amount of vinculin in MTI-5 cells increased in parallel with increase in the level of drebrin.	mti-5	26-31	vinculin	Mus musculus	14-22
7593207-8	1995	Pretreatment of B16a cells with either calphostin C or genistein abolished 12(S)-HETE-increased formation of vinculin- and phosphotyrosine-containing focal adhesions.	Carbon	50-51	vinculin	Mus musculus	109-117
7593207-8	1995	Pretreatment of B16a cells with either calphostin C or genistein abolished 12(S)-HETE-increased formation of vinculin- and phosphotyrosine-containing focal adhesions.	Genistein	55-64	vinculin	Mus musculus	109-117
7593207-8	1995	Pretreatment of B16a cells with either calphostin C or genistein abolished 12(S)-HETE-increased formation of vinculin- and phosphotyrosine-containing focal adhesions.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	75-85	vinculin	Mus musculus	109-117
7518470-9	1994	In addition, phosphotyrosine staining colocalized with vinculin within structures in the lamellapodia of these cells.	Phosphotyrosine	13-28	vinculin	Mus musculus	55-63
7527052-1	1994	Mouse Swiss 3T3 fibroblasts cultured in serum-free medium lose their actin stress fibres and vinculin-containing focal adhesions, a process that can be reversed by the addition of serum, lysophosphatidic acid (LPA) or bombesin, and is mediated by rhoA (A. J. Ridley and A.	lysophosphatidic acid	187-208	vinculin	Mus musculus	93-101
7527052-1	1994	Mouse Swiss 3T3 fibroblasts cultured in serum-free medium lose their actin stress fibres and vinculin-containing focal adhesions, a process that can be reversed by the addition of serum, lysophosphatidic acid (LPA) or bombesin, and is mediated by rhoA (A. J. Ridley and A.	lysophosphatidic acid	210-213	vinculin	Mus musculus	93-101
7593175-3	1995	Immunofluorescence microscopy revealed that the NH2Cl-induced peeling off of WI-38 fibroblasts is accompanied by disorganization of integrin alpha 5 beta 1, vinculin, stress fibers, and phosphotyrosine (p-Tyr)-containing proteins.	chloramine	48-53	vinculin	Mus musculus	157-165
7669900-0	1995	Interaction of the 47-kDa talin fragment and the 32-kDa vinculin fragment with acidic phospholipids: a computer analysis.	Phospholipids	86-99	vinculin	Mus musculus	56-64
7669900-1	1995	In recent in vitro experiments, it has been demonstrated that the 47-kDa fragment of the talin molecule and the 32-kDa fragment of the vinculin molecule interact with acidic phospholipids.	Phospholipids	174-187	vinculin	Mus musculus	135-143
1589868-2	1992	After 1 hr of incubation with 2 microM rotenone (inhibitor of respiration) in glucose-free medium, when ATP level was 4% of the initial level, there were increases in triton-insoluble actin and vinculin levels (2.5-fold and 2.8-fold, respectively) and 44% of cells showed blebs; such treatment damaged cells irreversibly.	Rotenone	39-47	vinculin	Mus musculus	194-202
8422710-7	1993	Additionally, adriamycin treatment caused a dramatic increase in focal contact formation by these melanoma cells, as assessed by fluorescent microscopy of actin and vinculin.	Doxorubicin	14-24	vinculin	Mus musculus	165-173
8288618-6	1994	Similarly, PIP2 bound to vinculin is decreased upon stimulation with PDGF.	Phosphatidylinositol 4,5-Diphosphate	11-15	vinculin	Mus musculus	25-33
8288618-7	1994	By immunofluorescent staining, PIP2 was found to be present densely in the central areas around nuclei, microfilament bundles, and focal contacts, where alpha-actinin and vinculin are distributed.	Phosphatidylinositol 4,5-Diphosphate	31-35	vinculin	Mus musculus	171-179
8288618-9	1994	In this paper we suggest that tyrosine kinase-activated phospholipase C hydrolyzes PIP2 bound to alpha-actinin and vinculin, leading to the simultaneous generation of second messengers and reorganization of the cytoskeleton.	Phosphatidylinositol 4,5-Diphosphate	83-87	vinculin	Mus musculus	115-123
1400584-3	1992	Restoration of vinculin in these cells, up to the levels found in 3T3 cells, resulted in an apparent increase in substrate adhesiveness, a decrease in the ability to grow in soft agar, and suppression of their capacity to develop tumors after injection into syngeneic hosts or nude mice.	Agar	179-183	vinculin	Mus musculus	15-23
26240176-5	2015	Compared to cells expressing wild-type or constitutively active vinculin, we found reduced tractions, cytoskeletal stiffness, adhesion strength, and increased vinculin dynamics in cells expressing constitutively inactive vinculin or vinculin where Src-mediated phosphorylation was blocked by replacing tyrosine at position 100 and/or 1065 with a non-phosphorylatable phenylalanine residue.	Tyrosine	302-310	vinculin	Mus musculus	64-72
2123807-2	1990	In this study, we analyzed the interactions of vinculin and fibronectin with plasma membrane proteins separated by sodium dodecyl sulphate (SDS) polyacrylamide gel electrophoresis, and then transferred onto polyvinylidene-difluoride (PVDF) paper.	Sodium Dodecyl Sulfate	115-138	vinculin	Mus musculus	47-55
2123807-2	1990	In this study, we analyzed the interactions of vinculin and fibronectin with plasma membrane proteins separated by sodium dodecyl sulphate (SDS) polyacrylamide gel electrophoresis, and then transferred onto polyvinylidene-difluoride (PVDF) paper.	Sodium Dodecyl Sulfate	140-143	vinculin	Mus musculus	47-55
2123807-2	1990	In this study, we analyzed the interactions of vinculin and fibronectin with plasma membrane proteins separated by sodium dodecyl sulphate (SDS) polyacrylamide gel electrophoresis, and then transferred onto polyvinylidene-difluoride (PVDF) paper.	polyacrylamide	145-159	vinculin	Mus musculus	47-55
2123807-2	1990	In this study, we analyzed the interactions of vinculin and fibronectin with plasma membrane proteins separated by sodium dodecyl sulphate (SDS) polyacrylamide gel electrophoresis, and then transferred onto polyvinylidene-difluoride (PVDF) paper.	polyvinylidene fluoride	234-238	vinculin	Mus musculus	47-55
26240176-5	2015	Compared to cells expressing wild-type or constitutively active vinculin, we found reduced tractions, cytoskeletal stiffness, adhesion strength, and increased vinculin dynamics in cells expressing constitutively inactive vinculin or vinculin where Src-mediated phosphorylation was blocked by replacing tyrosine at position 100 and/or 1065 with a non-phosphorylatable phenylalanine residue.	Phenylalanine	367-380	vinculin	Mus musculus	64-72
26240176-6	2015	Replacing tyrosine residues with phospho-mimicking glutamic acid residues restored cellular tractions, stiffness and adhesion strength, as well as vinculin dynamics, and facilitated vinculin-actin binding.	Tyrosine	10-18	vinculin	Mus musculus	147-155
26240176-6	2015	Replacing tyrosine residues with phospho-mimicking glutamic acid residues restored cellular tractions, stiffness and adhesion strength, as well as vinculin dynamics, and facilitated vinculin-actin binding.	Tyrosine	10-18	vinculin	Mus musculus	182-190
26240176-6	2015	Replacing tyrosine residues with phospho-mimicking glutamic acid residues restored cellular tractions, stiffness and adhesion strength, as well as vinculin dynamics, and facilitated vinculin-actin binding.	Glutamic Acid	51-64	vinculin	Mus musculus	182-190
34180140-4	2021	Furthermore, ACY1215 pretreatment increased the level of ATM, gamma-H2AX, Chk2, p53, p21, F-actin and vinculin in ALF.	ricolinostat	13-20	vinculin	Mus musculus	102-110
34180140-6	2021	The ATM inhibitor KU55933 could decrease the level of ATM, gamma-H2AX, Chk2, p53, p21, F-actin and vinculin in ALF with ACY1215 pretreatment.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	18-25	vinculin	Mus musculus	99-107
34180140-6	2021	The ATM inhibitor KU55933 could decrease the level of ATM, gamma-H2AX, Chk2, p53, p21, F-actin and vinculin in ALF with ACY1215 pretreatment.	ricolinostat	120-127	vinculin	Mus musculus	99-107
34180140-7	2021	The F-actin inhibitor cytochalasin B decreased the level of F-actin and vinculin in ALF with ACY1215 pretreatment.	ricolinostat	93-100	vinculin	Mus musculus	72-80
3093072-3	1986	Prolonged incubation with TPA allowed P- cells to regain their original appearance and resulted in growth inhibition; however, the extended presence of TPA produced in P+ cells persistent alterations in the distribution of actin, vinculin, and fibronectin.	Tetradecanoylphorbol Acetate	152-155	vinculin	Mus musculus	230-238
3080438-3	1986	Removal of vinculin from adhesion plaques following exposure of cells to PDGF was temperature dependent, occurred in many fibroblast cell lines, and could be mimicked by 12-tetradecanoyl phorbol-13-acetate (TPA; 5-125 nM) or melittin (0.35 microM).	Tetradecanoylphorbol Acetate	170-205	vinculin	Mus musculus	11-19
3086110-11	1986	In contrast to the induction by NaCl buffer, treatment with Tween 80 induced numerous tiny actin rods at 4 degrees C, which became larger when further incubated at 37 degrees C. Double immunofluorescence staining with anti-actin antibody and anti-vinculin antibody showed that vinculin plaques remained at least in an early stage of the actin rod formation.	Polysorbates	60-68	vinculin	Mus musculus	247-255
3086110-11	1986	In contrast to the induction by NaCl buffer, treatment with Tween 80 induced numerous tiny actin rods at 4 degrees C, which became larger when further incubated at 37 degrees C. Double immunofluorescence staining with anti-actin antibody and anti-vinculin antibody showed that vinculin plaques remained at least in an early stage of the actin rod formation.	Polysorbates	60-68	vinculin	Mus musculus	277-285
3093257-0	1986	Reorganization of alpha-actinin and vinculin in living cells following ATP depletion and replenishment.	Adenosine Triphosphate	71-74	vinculin	Mus musculus	36-44
3083582-3	1986	The distribution of vinculin, alpha-actinin, actin, and surface fibronectin was studied, and, where appropriate, also the extent of phosphotyrosine modification of vinculin.	Phosphotyrosine	132-147	vinculin	Mus musculus	164-172
3083582-8	1986	Irrespective of cell morphology, the extent of tyrosine phosphorylation of vinculin was high in all cells transformed by viruses carrying the src gene, but low in those transformed by viruses expressing the fps gene.	Tyrosine	47-55	vinculin	Mus musculus	75-83
3080438-3	1986	Removal of vinculin from adhesion plaques following exposure of cells to PDGF was temperature dependent, occurred in many fibroblast cell lines, and could be mimicked by 12-tetradecanoyl phorbol-13-acetate (TPA; 5-125 nM) or melittin (0.35 microM).	Tetradecanoylphorbol Acetate	207-210	vinculin	Mus musculus	11-19
3080438-5	1986	The removal of vinculin from adhesion plaques was inhibited by trifluoroperazine (TFP; 2.5 microM).	Trifluoperazine	63-80	vinculin	Mus musculus	15-23
3080438-5	1986	The removal of vinculin from adhesion plaques was inhibited by trifluoroperazine (TFP; 2.5 microM).	Trifluoperazine	82-85	vinculin	Mus musculus	15-23
3080438-7	1986	Melittin disruption of vinculin was inhibited by (in order of decreasing effectiveness) mepacrine greater than TMB-8 greater than TFP greater than leupeptin greater than PMSF, whereas A23187 and amiloride had no effect.	Quinacrine	88-97	vinculin	Mus musculus	23-31
3080438-7	1986	Melittin disruption of vinculin was inhibited by (in order of decreasing effectiveness) mepacrine greater than TMB-8 greater than TFP greater than leupeptin greater than PMSF, whereas A23187 and amiloride had no effect.	8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate	111-116	vinculin	Mus musculus	23-31
3080438-7	1986	Melittin disruption of vinculin was inhibited by (in order of decreasing effectiveness) mepacrine greater than TMB-8 greater than TFP greater than leupeptin greater than PMSF, whereas A23187 and amiloride had no effect.	leupeptin	147-156	vinculin	Mus musculus	23-31
3080438-7	1986	Melittin disruption of vinculin was inhibited by (in order of decreasing effectiveness) mepacrine greater than TMB-8 greater than TFP greater than leupeptin greater than PMSF, whereas A23187 and amiloride had no effect.	Phenylmethylsulfonyl Fluoride	170-174	vinculin	Mus musculus	23-31
3080438-9	1986	The observation that both PDGF- and melittin-induced removal of vinculin from adhesion plaques is inhibited by mepacrine suggests that phospholipase activation may be an early and important step in PDGF-induced disruption of vinculin from adhesion plaques.	Quinacrine	111-120	vinculin	Mus musculus	64-72
3080438-9	1986	The observation that both PDGF- and melittin-induced removal of vinculin from adhesion plaques is inhibited by mepacrine suggests that phospholipase activation may be an early and important step in PDGF-induced disruption of vinculin from adhesion plaques.	Quinacrine	111-120	vinculin	Mus musculus	225-233
6325428-0	1984	Vinculin phosphorylation in response to calcium and phorbol esters in intact cells.	Calcium	40-47	vinculin	Mus musculus	0-8
3920222-6	1985	Other competence-inducing factors (fibroblast growth factor, calcium phosphate, and choleragen) and tumor growth factor produced similar alterations in vinculin and actin distribution as did PDGF, though not to the same extent.	calcium phosphate	61-78	vinculin	Mus musculus	152-160
6325428-0	1984	Vinculin phosphorylation in response to calcium and phorbol esters in intact cells.	Phorbol Esters	52-66	vinculin	Mus musculus	0-8
6325428-2	1984	Increased phosphorylation of vinculin was noted as early as 10 min following phorbol 12-myristate 13-acetate treatment and was maximal at about 1 h. Maximal increases in phosphorylation were noted at approximately 100 nM phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	77-108	vinculin	Mus musculus	29-37
6325428-2	1984	Increased phosphorylation of vinculin was noted as early as 10 min following phorbol 12-myristate 13-acetate treatment and was maximal at about 1 h. Maximal increases in phosphorylation were noted at approximately 100 nM phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	221-252	vinculin	Mus musculus	29-37
6325428-3	1984	Phorbol 12,13-dibutyrate (80 nM), a less potent phorbol ester, resulted in smaller increases in vinculin phosphorylation than phorbol 12-myristate 13-acetate at equimolar concentrations.	Phorbol 12,13-Dibutyrate	0-24	vinculin	Mus musculus	96-104
6325428-3	1984	Phorbol 12,13-dibutyrate (80 nM), a less potent phorbol ester, resulted in smaller increases in vinculin phosphorylation than phorbol 12-myristate 13-acetate at equimolar concentrations.	Phorbol Esters	48-61	vinculin	Mus musculus	96-104
6325428-6	1984	Tryptic peptide analysis of vinculin revealed multisite phosphorylation.	Peptides	8-15	vinculin	Mus musculus	28-36
29040955-8	2017	The EGCG restored arsenic induced decrements in epididymal sperm concentration, kinematic attributes (total motility, rapid, progressive motile, fast progressive, VSL, VAP, VCL, BCF, LIN, WOB, STR and Type A), structutal membrane integrity, functional membrane integrity and mitochondrial membrane potential.	epigallocatechin gallate	4-8	vinculin	Mus musculus	173-176
33573304-6	2021	To demonstrate the variability in focal contacts pattern, the effect of graphene on vinculin was examined, which revealed a significant increase in focal contact size comparing to control-glass slide.	Graphite	72-80	vinculin	Mus musculus	84-92
32777343-13	2020	Quantification of immunostaining for vinculin and integrinbeta1 adhesions revealed that Periostin is required for the formation of focal and fibrillar adhesions in mPFBs.	mpfbs	164-169	vinculin	Mus musculus	37-45
32863238-9	2020	Moreover, nHDL suppressed miR-24-3p expression to increase vinculin expression resulting in nitric oxide (NO) production, whereas dHDL delivered miR-24-3p to inhibit vinculin expression leading to superoxide anion (O2 -) generation via scavenger receptor class B type 1.	Nitric Oxide	92-104	vinculin	Mus musculus	59-67
29945484-7	2019	Moreover, quercetin inhibited the LPS-induced expression of p-FAK, p-paxillin, FAK, and paxillin as well as the cytoskeletal adapter proteins vinculin and Tensin-2.	Quercetin	10-19	vinculin	Mus musculus	142-150
30735289-5	2019	Vinculin staining demonstrated how the Sa value affected cellular attachment to the substrate.	2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine	39-41	vinculin	Mus musculus	0-8
30172934-5	2018	To demonstrate the diagnostic potential of these TiO2 NT imaging platforms, the focal adhesion protein vinculin and actin cytoskeletal filaments were fluorescently tagged in osteoblasts and real-time, high-resolution fluorescent microscopy of live-cell interactions with TiO2 NT substrates were observed.	tio2 nt	49-56	vinculin	Mus musculus	103-111
29677519-0	2018	Suspended graphene oxide nanosheets maintain the self-renewal of mouse embryonic stem cells via down-regulating the expression of Vinculin.	graphene oxide	10-24	vinculin	Mus musculus	130-138
29256438-6	2018	Compared with the CS and NP-CS coatings, the NW-CS coating possessed a larger surface area and pore volume, beneficial protein adsorption, up-regulated the expression levels of integrin beta1, Vinculin and focal adhesion kinase and promoted cell spreading.	Asn-Trp	45-47	vinculin	Mus musculus	193-201
31483951-6	2019	Eucalyptol induces focal adhesion proteins of paxillin, vinculin, talin1, FAK, and Src in glucose-exposed podocytes and diabetic kidneys.	Eucalyptol	0-10	vinculin	Mus musculus	56-64
31483833-8	2019	While both MVcn and Vcn were observed at FAs, MVcn-expressing cells had larger but fewer focal adhesions per cell compared to Vcn-expressing cells.	ammonium ferrous sulfate	41-44	vinculin	Mus musculus	11-15
31483833-8	2019	While both MVcn and Vcn were observed at FAs, MVcn-expressing cells had larger but fewer focal adhesions per cell compared to Vcn-expressing cells.	ammonium ferrous sulfate	41-44	vinculin	Mus musculus	12-15
31483833-8	2019	While both MVcn and Vcn were observed at FAs, MVcn-expressing cells had larger but fewer focal adhesions per cell compared to Vcn-expressing cells.	ammonium ferrous sulfate	41-44	vinculin	Mus musculus	20-23
31483833-10	2019	Magnetic tweezer measurements on Vcn-expressing cells show a typical cell stiffening phenotype in response to externally applied force; however, this was absent in Vcn-null and MVcn-expressing cells.	tweezer	9-16	vinculin	Mus musculus	33-36