PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
7623808-5	1995	DNA replication initiates within this region in the single-copy CAD gene in Syrian baby hamster kidney cells and in the large chromosomal amplicons that were generated after selection with N-phosphonacetyl-L-aspartate, a specific inhibitor of CAD.	sparfosic acid	189-217	CAD protein	Mesocricetus auratus	243-246
7623808-3	1995	The biochemical and functional evidence presented here demonstrates that an origin of bidirectional replication (OBR) resides within the constitutively expressed housekeeping gene CAD, which encodes the first three reactions of de novo uridine biosynthesis (carbamoyl-phosphate synthetase, aspartate carbamoyltransferase, and dihydroorotase).	Uridine	236-243	CAD protein	Mesocricetus auratus	180-183
8868464-1	1996	Cells often acquire resistance to the antiproliferative agents methotrexate (MTX) or N-phosphonacetyl-L-aspartate (PALA) through amplification of genes encoding the target enzymes dihydrofolate reductase or carbamylphosphate synthetase/aspartate transcarbamylase/dihydroorotase (CAD), respectively.	Methotrexate	63-75	CAD protein	Mesocricetus auratus	207-283
8868464-1	1996	Cells often acquire resistance to the antiproliferative agents methotrexate (MTX) or N-phosphonacetyl-L-aspartate (PALA) through amplification of genes encoding the target enzymes dihydrofolate reductase or carbamylphosphate synthetase/aspartate transcarbamylase/dihydroorotase (CAD), respectively.	Methotrexate	77-80	CAD protein	Mesocricetus auratus	207-283
8868464-1	1996	Cells often acquire resistance to the antiproliferative agents methotrexate (MTX) or N-phosphonacetyl-L-aspartate (PALA) through amplification of genes encoding the target enzymes dihydrofolate reductase or carbamylphosphate synthetase/aspartate transcarbamylase/dihydroorotase (CAD), respectively.	sparfosic acid	85-113	CAD protein	Mesocricetus auratus	207-283
7623808-6	1995	DNA synthesis also initiates within this OBR in autonomously replicating extrachromosomal amplicons (CAD episomes) located in an N-phosphonacetyl-L-aspartate-resistant clone (5P20) of CHOK1 cells.	sparfosic acid	129-157	CAD protein	Mesocricetus auratus	101-104
1681900-0	1991	Identification of the ATP binding sites of the carbamyl phosphate synthetase domain of the Syrian hamster multifunctional protein CAD by affinity labeling with 5"-[p-(fluorosulfonyl)benzoyl]adenosine.	Adenosine Triphosphate	22-25	CAD protein	Mesocricetus auratus	130-133
1681900-0	1991	Identification of the ATP binding sites of the carbamyl phosphate synthetase domain of the Syrian hamster multifunctional protein CAD by affinity labeling with 5"-[p-(fluorosulfonyl)benzoyl]adenosine.	5'-(4-fluorosulfonylbenzoyl)adenosine	160-199	CAD protein	Mesocricetus auratus	130-133
1681900-3	1991	ATP protected CAD against inactivation by FSBA whereas the presence of the allosteric effectors UTP and PRPP afforded little protection, which suggests that the ATP binding sites were specifically labeled.	Adenosine Triphosphate	0-3	CAD protein	Mesocricetus auratus	14-17
1681900-8	1991	Amino acid sequencing of the principal peaks resulting from tryptic digests of FSBA-modified CAD located the sites of FSBA modification in regions that exhibit high homology to ATP binding sites of other known proteins.	Adenosine Triphosphate	177-180	CAD protein	Mesocricetus auratus	93-96
1681900-9	1991	Thus CAD has two ATP binding sites, one in each of the two highly homologous halves of the carbamyl phosphate domain which catalyze distinct ATP-dependent partial reactions in carbamyl phosphate synthesis.	Adenosine Triphosphate	17-20	CAD protein	Mesocricetus auratus	5-8
1681900-9	1991	Thus CAD has two ATP binding sites, one in each of the two highly homologous halves of the carbamyl phosphate domain which catalyze distinct ATP-dependent partial reactions in carbamyl phosphate synthesis.	Carbamyl Phosphate	91-109	CAD protein	Mesocricetus auratus	5-8
1681900-9	1991	Thus CAD has two ATP binding sites, one in each of the two highly homologous halves of the carbamyl phosphate domain which catalyze distinct ATP-dependent partial reactions in carbamyl phosphate synthesis.	Adenosine Triphosphate	141-144	CAD protein	Mesocricetus auratus	5-8
1681900-9	1991	Thus CAD has two ATP binding sites, one in each of the two highly homologous halves of the carbamyl phosphate domain which catalyze distinct ATP-dependent partial reactions in carbamyl phosphate synthesis.	Carbamyl Phosphate	176-194	CAD protein	Mesocricetus auratus	5-8
2462483-1	1988	The enzymes in the pathway for de novo pyrimidine biosynthesis, including those associated with the tri-functional CAD protein, show a marked increase in activity in rapidly growing cells and tissues.	pyrimidine	39-49	CAD protein	Mesocricetus auratus	115-118
1982061-1	1990	The carbamoylphosphate synthetase-aspartate transcarbamylase-dihydroorotase (CAD) gene encodes a tri-functional protein catalyzing the first three steps in de novo pyrimidine biosynthesis.	pyrimidine	164-174	CAD protein	Mesocricetus auratus	4-75
1982061-1	1990	The carbamoylphosphate synthetase-aspartate transcarbamylase-dihydroorotase (CAD) gene encodes a tri-functional protein catalyzing the first three steps in de novo pyrimidine biosynthesis.	pyrimidine	164-174	CAD protein	Mesocricetus auratus	77-80
381311-1	1979	Mutant Syrian hamster cells resistant to N-(phosphonacetyl)-L-aspartate (PALA), a transition state analog inhibitor of aspartate transcarbamylase, overproduce CAD, a multifunctional protein which catalyzes the first three reactions of de novo UMP biosynthesis.	sparfosic acid	41-71	CAD protein	Mesocricetus auratus	159-162
6656763-1	1983	Syrian hamster cell lines selected in multiple steps for resistance to high levels of N-(phosphonacetyl)-L-aspartate (PALA) contain many copies of the gene coding for the pyrimidine pathway enzyme CAD.	sparfosic acid	86-116	CAD protein	Mesocricetus auratus	197-200
6656763-1	1983	Syrian hamster cell lines selected in multiple steps for resistance to high levels of N-(phosphonacetyl)-L-aspartate (PALA) contain many copies of the gene coding for the pyrimidine pathway enzyme CAD.	pyrimidine	171-181	CAD protein	Mesocricetus auratus	197-200
6896736-1	1982	Mutant Syrian hamster cell lines resistant to N-(phosphonacetyl)-L-aspartate, a potent and specific inhibitor of aspartate transcarbamylase, have amplified the gene coding for the multifunctional protein (CAD) that includes this activity.	sparfosic acid	46-76	CAD protein	Mesocricetus auratus	205-208
6180304-1	1982	Syrian hamster cells resistant to N-(phosphonacetyl)-L-aspartate (PALA), a specific inhibitor of the aspartate transcarbamylase activity of the multifunctional protein CAD, overproduce this protein as a result of amplification of the CAD gene.	sparfosic acid	34-64	CAD protein	Mesocricetus auratus	168-171
6180304-1	1982	Syrian hamster cells resistant to N-(phosphonacetyl)-L-aspartate (PALA), a specific inhibitor of the aspartate transcarbamylase activity of the multifunctional protein CAD, overproduce this protein as a result of amplification of the CAD gene.	sparfosic acid	34-64	CAD protein	Mesocricetus auratus	234-237
6180304-1	1982	Syrian hamster cells resistant to N-(phosphonacetyl)-L-aspartate (PALA), a specific inhibitor of the aspartate transcarbamylase activity of the multifunctional protein CAD, overproduce this protein as a result of amplification of the CAD gene.	sparfosic acid	66-70	CAD protein	Mesocricetus auratus	168-171
6180304-1	1982	Syrian hamster cells resistant to N-(phosphonacetyl)-L-aspartate (PALA), a specific inhibitor of the aspartate transcarbamylase activity of the multifunctional protein CAD, overproduce this protein as a result of amplification of the CAD gene.	sparfosic acid	66-70	CAD protein	Mesocricetus auratus	234-237
6180304-10	1982	Using recombinant DNA plasmids nick-translated with [125I]dCTP to high specific radioactivity, 10 CAD genes in a single chromosomal region were revealed after 1 week of autoradiographic exposure, and the position of the unique gene could be seen after 1 month.	2'-deoxycytidine 5'-triphosphate	58-62	CAD protein	Mesocricetus auratus	98-101