PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 22419270-0 2012 Chemical analysis and acetylcholinesterase inhibitory effect of anthocyanin-rich red leaf tea (cv. anthocyanin-rich red leaf tea 64-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 22818849-1 2012 New tacrine derivatives 5a-d, 6a-d with piperazino-ethyl spacer linked with corresponding secondary amines and tacrine homodimer 8 were synthesized and tested as cholinesterase inhibitors on human acetylcholinesterase (hAChE) and human plasmatic butyrylcholinesterase (hBChE). Tacrine 4-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 219-224 22818849-2 2012 In most cases the majority of synthesized derivatives exhibit a high AChE and BChE inhibitory activity with IC(50) values in the low-nanomolar range, being clearly more potent than the reference standard tacrine (9-amino-1,2,3,4-tetrahydroacridine, 1) and 7-MEOTA (7-methoxy-9-amino-1,2,3,4-tetrahydroacridine). Tacrine 204-211 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 22805525-3 2012 In human erythrocytes, AChE(H) is a glycophosphatidylinositol-linked dimer on the plasma membrane. glycophosphatidylinositol 36-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 22691879-1 2012 To study prospectively influences of donepezil, an acetylcholinesterase inhibitor against Alzheimer disease, on cardiovascular system, we evaluated cardiovascular changes occurring during new initialized treatment with donepezil in 49 dementia patients over 6 months. Donepezil 37-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 23073222-5 2012 The models revealed the importance of protonated pyridine nitrogen of tacrine moiety for anti AChE activity, and recognized HBA and HBD interactions as highly important for the potency. Tacrine 70-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 23073222-7 2012 MIFs calculated with the N1 (pyridinium nitrogen) and the DRY GRID probes in the AChE active site enabled us to establish the relationship between amino acid residues within AChE active site and the variables having high impact on models. 4-(2-(4-isopropylbenzamido)ethoxy)benzoic acid 25-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 23073222-7 2012 MIFs calculated with the N1 (pyridinium nitrogen) and the DRY GRID probes in the AChE active site enabled us to establish the relationship between amino acid residues within AChE active site and the variables having high impact on models. pyridine 29-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 23073222-7 2012 MIFs calculated with the N1 (pyridinium nitrogen) and the DRY GRID probes in the AChE active site enabled us to establish the relationship between amino acid residues within AChE active site and the variables having high impact on models. pyridine 29-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 23073222-7 2012 MIFs calculated with the N1 (pyridinium nitrogen) and the DRY GRID probes in the AChE active site enabled us to establish the relationship between amino acid residues within AChE active site and the variables having high impact on models. Nitrogen 40-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 23073222-7 2012 MIFs calculated with the N1 (pyridinium nitrogen) and the DRY GRID probes in the AChE active site enabled us to establish the relationship between amino acid residues within AChE active site and the variables having high impact on models. Nitrogen 40-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 22915447-2 2012 This report presents an efficacy and safety study of the acetylcholinesterase inhibitor donepezil hydrochloride in PDD. Donepezil 88-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 22238217-0 2012 Toxicity and efficacy of the acetylcholinesterase (AChe) inhibitor donepezil in childhood brain tumor survivors: a pilot study. Donepezil 67-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 22238217-0 2012 Toxicity and efficacy of the acetylcholinesterase (AChe) inhibitor donepezil in childhood brain tumor survivors: a pilot study. Donepezil 67-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 22238217-2 2012 We evaluated the feasibility, tolerance, and impact of a pilot pharmacologic intervention with the acetylcholinesterase (AChe) inhibitor, donepezil, in pediatric brain tumor (BT) survivors at risk for neurocognitive dysfunction. Donepezil 138-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 22238217-2 2012 We evaluated the feasibility, tolerance, and impact of a pilot pharmacologic intervention with the acetylcholinesterase (AChe) inhibitor, donepezil, in pediatric brain tumor (BT) survivors at risk for neurocognitive dysfunction. Donepezil 138-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 22542756-1 2012 Organophosphates (OPs), which are widely used as pesticides, are acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 22542756-1 2012 Organophosphates (OPs), which are widely used as pesticides, are acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 22542756-1 2012 Organophosphates (OPs), which are widely used as pesticides, are acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. Organophosphates 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 22542756-1 2012 Organophosphates (OPs), which are widely used as pesticides, are acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. Organophosphates 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 22542756-2 2012 The inactivation of AChE results in the accumulation of acetylcholine at cholinergic receptor sites, causing a cholinergic crisis that can lead to death. Acetylcholine 56-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 22542756-7 2012 Molecular docking was used to predict the mechanism of IBTC interactions with the AChE active site. ibtc 55-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 22542756-9 2012 IBTC protected and reactivated both AChE and BChE activities. ibtc 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 22542756-10 2012 Molecular docking predicted that IBTC is positioned at the peripheral anionic site and in the acyl binding pocket of AChE and can interact with methamidophos, releasing the enzyme"s active site. ibtc 33-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 22542756-10 2012 Molecular docking predicted that IBTC is positioned at the peripheral anionic site and in the acyl binding pocket of AChE and can interact with methamidophos, releasing the enzyme"s active site. methamidophos 144-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 23293463-1 2012 OBJECTIVES: Retrospective analysis of the utility of serial measurements of serum acetylcholinesterase (AChE) in predicting the duration of stay in the intensive care unit (ICU), duration of mechanical ventilation (MV) and outcome of the patient from MV in organophosphate (OP) compound poisoning patients. Organophosphates 257-272 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 22419270-7 2012 The suppressive effect of "Sunrouge" water extract on AChE activity in human neuroblastoma SK-N-SH cells was the strongest among the three tea cultivars ("Sunrouge", "Yabukita" and "Benifuuki"). Water 37-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 22732728-12 2012 The methanolic and water extracts of the same plant exhibited high inhibitory effects towards AChE with IC(50) values of 0.22 and 0.26mg/ml, respectively. methanolic 4-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 22732728-12 2012 The methanolic and water extracts of the same plant exhibited high inhibitory effects towards AChE with IC(50) values of 0.22 and 0.26mg/ml, respectively. Water 19-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 22831800-2 2012 In order to further expand SAR study for inhibitions of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), the methyl group at the 3a-position of phenserine was replaced with an alkyl or alkenyl group, and its phenylcarbamoyl moiety was substituted at the o- or p-position. phenserine 158-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 22503707-0 2012 Comments to the Editor concerning the cholinergic response to manganese-induced neurotoxicity, based on the paper entitled "The inhibitory effect of manganese on acetylcholinesterase activity enhances oxidative stress and neuroinflammation in the brain" by Santos et al. Manganese 62-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-182 22503707-0 2012 Comments to the Editor concerning the cholinergic response to manganese-induced neurotoxicity, based on the paper entitled "The inhibitory effect of manganese on acetylcholinesterase activity enhances oxidative stress and neuroinflammation in the brain" by Santos et al. Manganese 149-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-182 22831800-2 2012 In order to further expand SAR study for inhibitions of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), the methyl group at the 3a-position of phenserine was replaced with an alkyl or alkenyl group, and its phenylcarbamoyl moiety was substituted at the o- or p-position. phenserine 158-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 22831800-4 2012 The bulkiness of the substituent at 3a-position of phenserine derivatives tends to reduce the inhibitory effect on AChE activity in the following order: methyl > ethyl > vinyl > propyl allyl > reverse-prenyl groups. phenserine 51-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 22817559-4 2012 The aim of our study was to investigate inhibition of human BChE and acetylcholinesterase (AChE) with metaproterenol, isoproterenol, and newly synthesized racemic bisdimethylcarbamate derivatives of metaproterenol (metacarb) and isoproterenol (isocarb) and their (R)-enantiomers to see if their bioconversion is affected by BChE inhibition in the same way as that for bambuterol. Metaproterenol 102-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 22817559-4 2012 The aim of our study was to investigate inhibition of human BChE and acetylcholinesterase (AChE) with metaproterenol, isoproterenol, and newly synthesized racemic bisdimethylcarbamate derivatives of metaproterenol (metacarb) and isoproterenol (isocarb) and their (R)-enantiomers to see if their bioconversion is affected by BChE inhibition in the same way as that for bambuterol. Metaproterenol 102-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 22817559-4 2012 The aim of our study was to investigate inhibition of human BChE and acetylcholinesterase (AChE) with metaproterenol, isoproterenol, and newly synthesized racemic bisdimethylcarbamate derivatives of metaproterenol (metacarb) and isoproterenol (isocarb) and their (R)-enantiomers to see if their bioconversion is affected by BChE inhibition in the same way as that for bambuterol. Isoproterenol 118-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 22817559-4 2012 The aim of our study was to investigate inhibition of human BChE and acetylcholinesterase (AChE) with metaproterenol, isoproterenol, and newly synthesized racemic bisdimethylcarbamate derivatives of metaproterenol (metacarb) and isoproterenol (isocarb) and their (R)-enantiomers to see if their bioconversion is affected by BChE inhibition in the same way as that for bambuterol. Isoproterenol 118-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 22817559-4 2012 The aim of our study was to investigate inhibition of human BChE and acetylcholinesterase (AChE) with metaproterenol, isoproterenol, and newly synthesized racemic bisdimethylcarbamate derivatives of metaproterenol (metacarb) and isoproterenol (isocarb) and their (R)-enantiomers to see if their bioconversion is affected by BChE inhibition in the same way as that for bambuterol. Metaproterenol 199-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 22817559-4 2012 The aim of our study was to investigate inhibition of human BChE and acetylcholinesterase (AChE) with metaproterenol, isoproterenol, and newly synthesized racemic bisdimethylcarbamate derivatives of metaproterenol (metacarb) and isoproterenol (isocarb) and their (R)-enantiomers to see if their bioconversion is affected by BChE inhibition in the same way as that for bambuterol. Metaproterenol 199-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 22817559-4 2012 The aim of our study was to investigate inhibition of human BChE and acetylcholinesterase (AChE) with metaproterenol, isoproterenol, and newly synthesized racemic bisdimethylcarbamate derivatives of metaproterenol (metacarb) and isoproterenol (isocarb) and their (R)-enantiomers to see if their bioconversion is affected by BChE inhibition in the same way as that for bambuterol. metacarb 215-223 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 22817559-4 2012 The aim of our study was to investigate inhibition of human BChE and acetylcholinesterase (AChE) with metaproterenol, isoproterenol, and newly synthesized racemic bisdimethylcarbamate derivatives of metaproterenol (metacarb) and isoproterenol (isocarb) and their (R)-enantiomers to see if their bioconversion is affected by BChE inhibition in the same way as that for bambuterol. Isoproterenol 229-242 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 22817559-4 2012 The aim of our study was to investigate inhibition of human BChE and acetylcholinesterase (AChE) with metaproterenol, isoproterenol, and newly synthesized racemic bisdimethylcarbamate derivatives of metaproterenol (metacarb) and isoproterenol (isocarb) and their (R)-enantiomers to see if their bioconversion is affected by BChE inhibition in the same way as that for bambuterol. Propoxur 244-251 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 22817559-4 2012 The aim of our study was to investigate inhibition of human BChE and acetylcholinesterase (AChE) with metaproterenol, isoproterenol, and newly synthesized racemic bisdimethylcarbamate derivatives of metaproterenol (metacarb) and isoproterenol (isocarb) and their (R)-enantiomers to see if their bioconversion is affected by BChE inhibition in the same way as that for bambuterol. bambuterol 368-378 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 22817559-5 2012 Metacarb and isocarb proved to be selective BChE inhibitors, as they progressively inhibited AChE 960 to 80 times more slowly than BChE(UU). metacarb 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 22817559-5 2012 Metacarb and isocarb proved to be selective BChE inhibitors, as they progressively inhibited AChE 960 to 80 times more slowly than BChE(UU). Propoxur 13-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 22732870-1 2012 We demonstrate a facile procedure to efficiently prepare Prussian blue nanocubes/reduced graphene oxide (PBNCs/rGO) nanocomposite by directly mixing Fe(3+) and [Fe(CN)(6)]((3)-) in the presence of GO in polyethyleneimine aqueous solution, resulting in a novel acetylcholinesterase (AChE) biosensor for detection of organophosphorus pesticides (OPs). ferric ferrocyanide 57-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 260-280 22732870-1 2012 We demonstrate a facile procedure to efficiently prepare Prussian blue nanocubes/reduced graphene oxide (PBNCs/rGO) nanocomposite by directly mixing Fe(3+) and [Fe(CN)(6)]((3)-) in the presence of GO in polyethyleneimine aqueous solution, resulting in a novel acetylcholinesterase (AChE) biosensor for detection of organophosphorus pesticides (OPs). ferric ferrocyanide 57-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 282-286 22421347-0 2012 The stabilization of Au NP-AChE nanocomposites by biosilica encapsulation for the development of a thiocholine biosensor. Gold 21-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 22421347-0 2012 The stabilization of Au NP-AChE nanocomposites by biosilica encapsulation for the development of a thiocholine biosensor. Thiocholine 99-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 22421347-8 2012 It is thus shown that the biosilica nanocomposites doped with Au NPs-AChE conjugates create a system that provides both signal mediation and significant enzyme stabilization over the existing AChE biosensor. Gold 62-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 22421347-8 2012 It is thus shown that the biosilica nanocomposites doped with Au NPs-AChE conjugates create a system that provides both signal mediation and significant enzyme stabilization over the existing AChE biosensor. Gold 62-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 22431227-8 2012 Propidium, an acetylcholinesterase inhibitor, was able to reverse the effects elicited by Abeta. Propidium 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 22768972-3 2012 AChE is a target of several toxins such as insecticide carbofuran, nerve agents, sarin, soman, tabun and VX. Carbofuran 55-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 22768972-3 2012 AChE is a target of several toxins such as insecticide carbofuran, nerve agents, sarin, soman, tabun and VX. Sarin 81-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 22768972-3 2012 AChE is a target of several toxins such as insecticide carbofuran, nerve agents, sarin, soman, tabun and VX. Soman 88-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 22726956-2 2012 It can accommodate larger substrates or inhibitors than acetylcholinesterase (AChE), the enzyme responsible for hydrolysis of the neurotransmitter acetylcholine in the central nervous system and neuromuscular junctions. Acetylcholine 56-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 22726956-3 2012 AChE is the specific target of organophosphorous pesticides and warfare nerve agents, and BChE is a stoichiometric bioscavenger. organophosphorous 31-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 22587993-3 2012 To address the functionality of this non-neuronal ACh machinery, we used cholinesterase inhibitors and a siRNA targeted to AChE (acetylcholinesterase) as a way to increase the availability of ACh secreted by cardiac cells. Acetylcholine 50-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 22587993-3 2012 To address the functionality of this non-neuronal ACh machinery, we used cholinesterase inhibitors and a siRNA targeted to AChE (acetylcholinesterase) as a way to increase the availability of ACh secreted by cardiac cells. Acetylcholine 50-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-149 22587993-3 2012 To address the functionality of this non-neuronal ACh machinery, we used cholinesterase inhibitors and a siRNA targeted to AChE (acetylcholinesterase) as a way to increase the availability of ACh secreted by cardiac cells. Acetylcholine 123-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-149 22211487-0 2012 Galantamine-based hybrid molecules with acetylcholinesterase, butyrylcholinesterase and gamma-secretase inhibition activities. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 22633691-0 2012 Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents. indacrinone 37-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 22633691-2 2012 Among them, compound 6a, with a piperidine group linked to indone by a two-carbon spacer, exhibited the most potent inhibitor activity, with an IC(50) of 0.0018 muM for AChE; the inhibitory activity of this compound was 14-fold more potent than that of donepezil. 1H-inden-1-one 59-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 22751086-3 2012 This study examined the effects of rivastigmine, a selective central nervous system acetylcholinesterase inhibitor, with benefits on cognition in Alzheimer disease, on memory performance in patients with schizophrenia treated with ECT. Rivastigmine 35-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 23117946-6 2012 Acetylcholinesterase inhibitors are often the first modality of therapy for MG. As an immune-mediated disorder, MG can respond to several immunosuppressive agents, such as corticosteroids, azathioprine, mycophenolate mofetil, and cyclosporin. Azathioprine 189-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 23117946-6 2012 Acetylcholinesterase inhibitors are often the first modality of therapy for MG. As an immune-mediated disorder, MG can respond to several immunosuppressive agents, such as corticosteroids, azathioprine, mycophenolate mofetil, and cyclosporin. Mycophenolic Acid 203-224 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 23117946-6 2012 Acetylcholinesterase inhibitors are often the first modality of therapy for MG. As an immune-mediated disorder, MG can respond to several immunosuppressive agents, such as corticosteroids, azathioprine, mycophenolate mofetil, and cyclosporin. Cyclosporine 230-241 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 22649796-0 2012 Reactivation kinetics of a series of related bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase--Structure-activity relationships. bispyridinium oximes 45-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 22649796-0 2012 Reactivation kinetics of a series of related bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase--Structure-activity relationships. Organophosphates 71-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 22649796-2 2012 However, numerous in vitro and in vivo studies demonstrated a limited ability of these oximes to reactivate acetylcholinesterase (AChE) inhibited by different OP pesticides and nerve agents. Oximes 87-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 22649796-2 2012 However, numerous in vitro and in vivo studies demonstrated a limited ability of these oximes to reactivate acetylcholinesterase (AChE) inhibited by different OP pesticides and nerve agents. Oximes 87-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 22649796-3 2012 New oximes were mostly tested for their therapeutic efficacy by using different animal models and for their reactivating potency with AChE from different species. Oximes 4-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 22649796-5 2012 Now, we found it tempting to determine the reactivation kinetics of a series of bispyridinium oximes bearing one or two oxime groups at different positions and having an oxybismethylene or a trimethylene linker under identical conditions with human AChE inhibited by structurally different OP. bispyridinium oximes 80-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 249-253 22649796-5 2012 Now, we found it tempting to determine the reactivation kinetics of a series of bispyridinium oximes bearing one or two oxime groups at different positions and having an oxybismethylene or a trimethylene linker under identical conditions with human AChE inhibited by structurally different OP. Oximes 94-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 249-253 22649796-7 2012 Hence, these and previous data emphasize the necessity for thorough kinetic investigations of OP-oxime-AChE interactions and underline the difficulty to develop a broad spectrum oxime reactivator which is efficient against structurally different OP inhibitors. op-oxime 94-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 22649796-7 2012 Hence, these and previous data emphasize the necessity for thorough kinetic investigations of OP-oxime-AChE interactions and underline the difficulty to develop a broad spectrum oxime reactivator which is efficient against structurally different OP inhibitors. Oximes 97-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 22539182-7 2012 Pharmacological studies showed that the complexes present a moderate inhibition of AChE with an IC(50) of 21 mumol L(-1) (referred to risvagtini, IC(50) 181 mumol L(-1) and galantamine IC(50) 0.006 mumol L(-1)) with no appreciable cytotoxicity toward to the HeLa cells (50% cell viability at 925 mumol L(-1)). risvagtini 134-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 22539182-7 2012 Pharmacological studies showed that the complexes present a moderate inhibition of AChE with an IC(50) of 21 mumol L(-1) (referred to risvagtini, IC(50) 181 mumol L(-1) and galantamine IC(50) 0.006 mumol L(-1)) with no appreciable cytotoxicity toward to the HeLa cells (50% cell viability at 925 mumol L(-1)). Galantamine 173-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 22692245-0 2012 Synthesis and biological evaluation of thiophene derivatives as acetylcholinesterase inhibitors. Thiophenes 39-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 22692245-2 2012 The acetylcholinesterase inhibition activity was assayed according to Ellman"s method using donepezil as reference. Donepezil 92-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 23227542-2 2012 The inhibitory effect of icariin on the activity of AChE was investigated by inhibition kinetics. icariin 25-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 23227542-4 2012 The results showed that icariin could potently inhibit the activity of AChE, the IC50 value was determined to be 3.50 x 10(-8) mol x L(-1), and the determined IC50 value to tacrine was 0.75 x 10(-8) mol x L(-1). icariin 24-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 23227542-4 2012 The results showed that icariin could potently inhibit the activity of AChE, the IC50 value was determined to be 3.50 x 10(-8) mol x L(-1), and the determined IC50 value to tacrine was 0.75 x 10(-8) mol x L(-1). Tacrine 173-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 23227542-5 2012 Kinetic analyses showed that icariin is a reversible and mixed type AChE inhibitor. icariin 29-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 23227542-7 2012 Icariin binds selectively to the AChE peripheral anionic site via hydrogen bonds and Van der Waals forces. icariin 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 23227542-7 2012 Icariin binds selectively to the AChE peripheral anionic site via hydrogen bonds and Van der Waals forces. Hydrogen 66-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 22738634-0 2012 Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase. aryl methylcarbamates 15-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-133 22738634-2 2012 Compounds bearing a beta-branched 2-alkoxy or 2-thioalkyl group were found to possess good selectivity for inhibition of Anopheles gambiae AChE over human AChE; up to 530-fold selectivity was achieved with carbamate 11d. Carbamates 206-215 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 22738634-2 2012 Compounds bearing a beta-branched 2-alkoxy or 2-thioalkyl group were found to possess good selectivity for inhibition of Anopheles gambiae AChE over human AChE; up to 530-fold selectivity was achieved with carbamate 11d. Carbamates 206-215 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 22561105-0 2012 Kinetic interactions of a homologous series of bispyridinium monooximes (HGG oximes) with native and phosphonylated human acetylcholinesterase. bispyridinium monooximes 47-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 22561105-0 2012 Kinetic interactions of a homologous series of bispyridinium monooximes (HGG oximes) with native and phosphonylated human acetylcholinesterase. Oximes 65-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 22561105-1 2012 Inhibition of acetylcholinesterase (AChE) is the main toxic mechanism of organophosphorus compounds (OP) and reactivation of OP-inhibited AChE by oximes is a mainstay of antidotal treatment. Organophosphorus Compounds 73-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 22561105-1 2012 Inhibition of acetylcholinesterase (AChE) is the main toxic mechanism of organophosphorus compounds (OP) and reactivation of OP-inhibited AChE by oximes is a mainstay of antidotal treatment. Organophosphorus Compounds 73-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 22561105-1 2012 Inhibition of acetylcholinesterase (AChE) is the main toxic mechanism of organophosphorus compounds (OP) and reactivation of OP-inhibited AChE by oximes is a mainstay of antidotal treatment. Oximes 146-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 22561105-1 2012 Inhibition of acetylcholinesterase (AChE) is the main toxic mechanism of organophosphorus compounds (OP) and reactivation of OP-inhibited AChE by oximes is a mainstay of antidotal treatment. Oximes 146-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 22561105-4 2012 In the present study we investigated the kinetic interactions of a homologous series of bispyridinium monoximes bearing C1 to C12 alkylketone groups on the second pyridinium ring with native and cyclosarin-inhibited human AChE. bispyridinium 88-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 222-226 22561105-4 2012 In the present study we investigated the kinetic interactions of a homologous series of bispyridinium monoximes bearing C1 to C12 alkylketone groups on the second pyridinium ring with native and cyclosarin-inhibited human AChE. cyclohexyl methylphosphonofluoridate 195-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 222-226 22624144-0 2012 Ionic liquid-functionalized graphene for fabricating an amperometric acetylcholinesterase biosensor. Graphite 28-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 22624144-1 2012 This work reports a sensitive amperometric biosensor for organophosphate pesticides (OPs) fabricated by modifying a glassy carbon electrode with acetylcholinesterase (AChE) immobilized on ionic liquid-functionalized graphene (IL-G). Organophosphates 57-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 22624144-1 2012 This work reports a sensitive amperometric biosensor for organophosphate pesticides (OPs) fabricated by modifying a glassy carbon electrode with acetylcholinesterase (AChE) immobilized on ionic liquid-functionalized graphene (IL-G). Organophosphates 57-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 22624144-1 2012 This work reports a sensitive amperometric biosensor for organophosphate pesticides (OPs) fabricated by modifying a glassy carbon electrode with acetylcholinesterase (AChE) immobilized on ionic liquid-functionalized graphene (IL-G). Graphite 216-224 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 22467516-0 2012 Design, synthesis and evaluation of novel 2-(aminoalkyl)-isoindoline-1,3-dione derivatives as dual-binding site acetylcholinesterase inhibitors. 2-(aminoalkyl)-isoindoline-1,3-dione 42-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 22467516-1 2012 A new series of 2-(diethylaminoalkyl)-isoindoline-1,3-dione derivatives intended as dual binding site cholinesterase inhibitors were designed using molecular modeling and evaluated as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and the formation of the beta-amyloid (Abeta) plaques. 2-(diethylaminoalkyl)-isoindoline-1,3-dione 16-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-218 22467516-1 2012 A new series of 2-(diethylaminoalkyl)-isoindoline-1,3-dione derivatives intended as dual binding site cholinesterase inhibitors were designed using molecular modeling and evaluated as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and the formation of the beta-amyloid (Abeta) plaques. 2-(diethylaminoalkyl)-isoindoline-1,3-dione 16-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 220-224 22467516-4 2012 These results support the outcome of docking studies which tested compounds targeting both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. Aminosalicylic Acid 156-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 22527006-7 2012 Among the targeted chemicals APs (0.66), PCBs (0.64), PAHs (0.61) and DDT (0.49) correlated well with the AChE bioassay. Adenosine Phosphosulfate 29-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 22527006-7 2012 Among the targeted chemicals APs (0.66), PCBs (0.64), PAHs (0.61) and DDT (0.49) correlated well with the AChE bioassay. Polychlorinated Biphenyls 41-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 22527006-7 2012 Among the targeted chemicals APs (0.66), PCBs (0.64), PAHs (0.61) and DDT (0.49) correlated well with the AChE bioassay. Polycyclic Aromatic Hydrocarbons 54-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 22527006-7 2012 Among the targeted chemicals APs (0.66), PCBs (0.64), PAHs (0.61) and DDT (0.49) correlated well with the AChE bioassay. DDT 70-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 22908593-0 2012 Acetylcholinesterase inhibition within the lycorine series of Amaryllidaceae alkaloids. lycorine 43-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 22908593-0 2012 Acetylcholinesterase inhibition within the lycorine series of Amaryllidaceae alkaloids. Amaryllidaceae Alkaloids 62-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 22908593-4 2012 The lycorine series of compounds within the family have recently emerged as novel inhibitors of AChE, in some instances with higher levels of activity compared with the commercial drug galanthamine, making them attractive targets for natural product and synthetically-driven structure-activity relationship studies. lycorine 4-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 22655699-1 2012 Inhibitors of acetylcholine breakdown by acetylcholinesterase (AChE) constitute the main therapeutic modality for Alzheimer"s disease. Acetylcholine 14-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 22655699-1 2012 Inhibitors of acetylcholine breakdown by acetylcholinesterase (AChE) constitute the main therapeutic modality for Alzheimer"s disease. Acetylcholine 14-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 22655699-6 2012 Safranal interacts only with the binding site of the AChE, but crocetin and dimethylcrocetin bind simultaneously to the catalytic and peripheral anionic sites. safranal 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 22211487-4 2012 Strikingly, two of the galantamine amides that displayed low activity towards acetylcholinesterase exhibited the highest inhibitory potency towards butyrylcholinesterase (106 to 133 times more active than galantamine). galantamine amides 23-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 22211487-4 2012 Strikingly, two of the galantamine amides that displayed low activity towards acetylcholinesterase exhibited the highest inhibitory potency towards butyrylcholinesterase (106 to 133 times more active than galantamine). Galantamine 23-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 29243607-3 2012 The active components were identified as prenylated flavonols (2-4) that inhibited two related human cholinesterases in a dose-dependent manner, with IC50"s ranging between 0.8 and 3.1muM and between 0.5 and 24.7muM against human acetylcholinesterase (hAChE) and butylcholinesterase (BChE), respectively. Flavonols 52-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 252-257 22503231-1 2012 The synthesis, pharmacological evaluation and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amines 1-7 of type I, and 9-12 of type II, designed as multipotent inhibitors able to simultaneously inhibit monoamine oxidases (MAO-A/B) as well as cholinesterase (AChE/BuChE) enzymes, as potential drugs for the treatment of Alzheimer"s disease, are described. cycloalkyl propargyl amines 103-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 289-293 22503231-2 2012 Indole derivatives 1-7 of type I are well known MAO inhibitors whose capacity to inhibit AChE and BuChE was here investigated for the first time. indole 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 22503231-4 2012 Conversely, the new and readily available 5-amino-7-(prop-2-yn-1-yl)-6,7,8,9-tetrahydropyrido[2,3-b][1,6]naphthyridine derivatives 9-13 of type II are poor MAO inhibitors, but showed AChE selective inhibition, compound 12 being the most attractive as it acts as a non-competitive inhibitor on EeAChE (IC(50) = 25 +- 3 nM, K(i) = 65 nM). 5-amino-7-(prop-2-yn-1-yl)-6,7,8,9-tetrahydropyrido[2,3-b][1,6]naphthyridine 42-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-187 22157329-1 2012 OBJECTIVE: To determine the efficacy of acotiamide, an acetylcholinesterase inhibitor, in patients with functional dyspepsia (FD) in a 4-week trial. Z 338 40-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 29243607-5 2012 Flavonols (2-4) showed mixed inhibition kinetics as well as slow and time-dependent reversible inhibition toward hAChE. Flavonols 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-118 22561476-0 2012 Successful treatment of musical hallucinations with the acetylcholinesterase inhibitor donepezil. Donepezil 87-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 22342984-1 2012 Organophosphorus (OP) nerve agents and pesticides inhibit acetylcholinesterase (AChE), and this is thought to be a primary mechanism mediating the neurotoxicity of these compounds. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 22816286-0 2012 A novel isopimarane diterpenoid with acetylcholinesterase inhibitory activity from Nepeta sorgerae, an endemic species to the Nemrut Mountain. ent-isopimarane 8-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 22816286-0 2012 A novel isopimarane diterpenoid with acetylcholinesterase inhibitory activity from Nepeta sorgerae, an endemic species to the Nemrut Mountain. Diterpenes 20-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 22816286-4 2012 Although the antioxidant activity results were low, the AChE enzyme inhibition of the extracts and terpenoids was very promising. Terpenes 99-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 22342984-1 2012 Organophosphorus (OP) nerve agents and pesticides inhibit acetylcholinesterase (AChE), and this is thought to be a primary mechanism mediating the neurotoxicity of these compounds. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 22503679-0 2012 Screen-printed acetylcholinesterase-based biosensors for inhibitive determination of permethrin. Permethrin 85-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 22498093-1 2012 Organophosphate (OP)-induced brain damage is defined as progressive damage to the brain, resulting from the cholinergic neuronal excitotoxicity and dysfunction induced by OP-induced irreversible AChE inhibition. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 22503679-1 2012 An amperometric assay based on acetylcholinesterase (AChE) inactivation has been developed for the monitoring of permethrin using a screen-printed three-electrode system. Permethrin 113-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 22503679-1 2012 An amperometric assay based on acetylcholinesterase (AChE) inactivation has been developed for the monitoring of permethrin using a screen-printed three-electrode system. Permethrin 113-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 22503679-2 2012 The enzyme AChE catalyzes the hydrolysis of acetylthiocholine to thiocholine, which can be electrochemically oxidized. Acetylthiocholine 44-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-15 22503679-2 2012 The enzyme AChE catalyzes the hydrolysis of acetylthiocholine to thiocholine, which can be electrochemically oxidized. Thiocholine 50-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-15 22503679-3 2012 The presence of permethrin inhibits the AChE activity, resulting in a lower thiocholine production and thus, a decrease in the amperometric oxidation current. Permethrin 16-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 22503679-3 2012 The presence of permethrin inhibits the AChE activity, resulting in a lower thiocholine production and thus, a decrease in the amperometric oxidation current. Thiocholine 76-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 22360473-0 2012 Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents. organophosphorus 50-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 22360473-4 2012 The acute toxicity of OPNAs results from the irreversible inhibition of acetylcholinesterase (AChE, EC 3.1.1.7) via the formation of a covalent P-O bond at the serine hydroxyl group in the enzyme active site. serine hydroxyl 160-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 22360473-4 2012 The acute toxicity of OPNAs results from the irreversible inhibition of acetylcholinesterase (AChE, EC 3.1.1.7) via the formation of a covalent P-O bond at the serine hydroxyl group in the enzyme active site. serine hydroxyl 160-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 22360473-5 2012 AChE breaks down the neurotransmitter acetylcholine at neuronal synapses and neuromuscular junctions. Acetylcholine 38-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 22360473-7 2012 The current treatment for OPNA poisoning combines an antimuscarinic drug (e.g., atropine), an anticonvulsant drug (e.g., diazepam), and an AChE reactivator of the pyridinium aldoxime family (pralidoxime, trimedoxime, obidoxime, HI-6, HLo-7). opna 26-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 22360473-7 2012 The current treatment for OPNA poisoning combines an antimuscarinic drug (e.g., atropine), an anticonvulsant drug (e.g., diazepam), and an AChE reactivator of the pyridinium aldoxime family (pralidoxime, trimedoxime, obidoxime, HI-6, HLo-7). pyridinium aldoxime 163-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 22360473-7 2012 The current treatment for OPNA poisoning combines an antimuscarinic drug (e.g., atropine), an anticonvulsant drug (e.g., diazepam), and an AChE reactivator of the pyridinium aldoxime family (pralidoxime, trimedoxime, obidoxime, HI-6, HLo-7). pralidoxime 191-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 22360473-7 2012 The current treatment for OPNA poisoning combines an antimuscarinic drug (e.g., atropine), an anticonvulsant drug (e.g., diazepam), and an AChE reactivator of the pyridinium aldoxime family (pralidoxime, trimedoxime, obidoxime, HI-6, HLo-7). Trimedoxime 204-215 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 22360473-7 2012 The current treatment for OPNA poisoning combines an antimuscarinic drug (e.g., atropine), an anticonvulsant drug (e.g., diazepam), and an AChE reactivator of the pyridinium aldoxime family (pralidoxime, trimedoxime, obidoxime, HI-6, HLo-7). Obidoxime Chloride 217-226 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 22360473-7 2012 The current treatment for OPNA poisoning combines an antimuscarinic drug (e.g., atropine), an anticonvulsant drug (e.g., diazepam), and an AChE reactivator of the pyridinium aldoxime family (pralidoxime, trimedoxime, obidoxime, HI-6, HLo-7). asoxime chloride 228-232 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 22360473-7 2012 The current treatment for OPNA poisoning combines an antimuscarinic drug (e.g., atropine), an anticonvulsant drug (e.g., diazepam), and an AChE reactivator of the pyridinium aldoxime family (pralidoxime, trimedoxime, obidoxime, HI-6, HLo-7). HLo 7 234-239 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 22381367-1 2012 Two microplate spectroscopic methods for determination of organophosphates, based on inhibition of acetylcholinesterase (AChE) activity, were further improved and evaluated for determination of the chemical weapon agent Russian VX (RVX) in aqueous solutions. Organophosphates 58-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 22381367-1 2012 Two microplate spectroscopic methods for determination of organophosphates, based on inhibition of acetylcholinesterase (AChE) activity, were further improved and evaluated for determination of the chemical weapon agent Russian VX (RVX) in aqueous solutions. Organophosphates 58-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 22381367-6 2012 A major product of RVX degradation, 2,2"-dithiobis(N,N-diethylethanamine), caused significant inhibition of AChE at concentrations of >=0.1 mM (P<0.01) and had a false positive effect at higher concentrations (>=2 mM). S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate 19-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 22381367-6 2012 A major product of RVX degradation, 2,2"-dithiobis(N,N-diethylethanamine), caused significant inhibition of AChE at concentrations of >=0.1 mM (P<0.01) and had a false positive effect at higher concentrations (>=2 mM). 2,2"-dithiobis 36-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 22381367-6 2012 A major product of RVX degradation, 2,2"-dithiobis(N,N-diethylethanamine), caused significant inhibition of AChE at concentrations of >=0.1 mM (P<0.01) and had a false positive effect at higher concentrations (>=2 mM). triethylamine 51-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 22430667-6 2012 The reaction kinetic parameters for AChE were successfully estimated with the silica particles and 2. Silicon Dioxide 78-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 22430667-7 2012 These results reveal that the ensemble of the silica particles and 2 can be utilized for AChE assay. Silicon Dioxide 46-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 22430667-8 2012 Moreover, the fluorescence spectra of the ensemble of the silica particles and 2 containing AChE were also measured after further addition of either neostigmine or tacrine which are typical inhibitors of AChE. Silicon Dioxide 58-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-208 22430667-9 2012 The results manifest that the ensemble of the emissive silica particles and 2 is also useful for screening the inhibitors of AChE. Silicon Dioxide 55-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 22594259-1 2012 A series of novel N-benzyl substituted amides of 1H-indole-5-carboxylic acid were synthesized and evaluated for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). n-benzyl substituted amides 18-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 22446730-0 2012 Acetylcholinesterase inhibition dose-response modeling for chlorpyrifos and chlorpyrifos-oxon. Chlorpyrifos 59-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 22446730-0 2012 Acetylcholinesterase inhibition dose-response modeling for chlorpyrifos and chlorpyrifos-oxon. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 76-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21850569-0 2012 Assessing the reactivation efficacy of hydroxylamine anion towards VX-inhibited AChE: a computational study. hydroxylamine anion 39-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 21937528-0 2012 Effects of dichlorvos and carbaryl on the activity of free and immobilized acetylcholinesterase. Dichlorvos 11-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 21937528-0 2012 Effects of dichlorvos and carbaryl on the activity of free and immobilized acetylcholinesterase. Carbaryl 26-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 21937528-1 2012 Acetylcholinesterase (AChE) is responsible for the rapid hydrolytic degradation of the neurotransmitter acetylcholine into inactive products choline and acetic acid. Acetylcholine 104-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21937528-1 2012 Acetylcholinesterase (AChE) is responsible for the rapid hydrolytic degradation of the neurotransmitter acetylcholine into inactive products choline and acetic acid. Acetylcholine 104-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 21937528-1 2012 Acetylcholinesterase (AChE) is responsible for the rapid hydrolytic degradation of the neurotransmitter acetylcholine into inactive products choline and acetic acid. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 21937528-1 2012 Acetylcholinesterase (AChE) is responsible for the rapid hydrolytic degradation of the neurotransmitter acetylcholine into inactive products choline and acetic acid. Acetic Acid 153-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21937528-1 2012 Acetylcholinesterase (AChE) is responsible for the rapid hydrolytic degradation of the neurotransmitter acetylcholine into inactive products choline and acetic acid. Acetic Acid 153-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 21937528-2 2012 The purpose of this study was to examine the effect of carbaryl and dichlorvos on the activity of AChE. Carbaryl 55-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 21937528-12 2012 AChE activity of free form is more affected by Dichlorvos (0.09 +- 0.03 mM/ml/min) than immobilized form (0.19 +- 0.02 mM/ml/min). Dichlorvos 47-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 21937528-13 2012 AChE activity of free form is more affected by carbaryl (0.11 +- 0.01 mM/ml/min) than immobilized form (0.1 +- 0.04 mM/ml/min). Carbaryl 47-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 21937528-14 2012 Comparison of mean AChE activity showed that the activity of the enzyme in presence of dichlorvos and carbaryl was significantly lower compared to controls. Dichlorvos 87-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 21937528-14 2012 Comparison of mean AChE activity showed that the activity of the enzyme in presence of dichlorvos and carbaryl was significantly lower compared to controls. Carbaryl 102-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 21937528-16 2012 The results of our study indicate that dichlorvos and carbaryl cause decrease in AChE activity for both free and immobilization form of enzyme. Dichlorvos 39-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 21937528-16 2012 The results of our study indicate that dichlorvos and carbaryl cause decrease in AChE activity for both free and immobilization form of enzyme. Carbaryl 54-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 21937528-17 2012 It is therefore concluded that measuring AChE activity is a way to evaluate poisoning with carbaryl and dichlorvos. Carbaryl 91-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 22534665-0 2012 Synthesis of new indole derivatives structurally related to donepezil and their biological evaluation as acetylcholinesterase inhibitors. indole 17-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 22534665-0 2012 Synthesis of new indole derivatives structurally related to donepezil and their biological evaluation as acetylcholinesterase inhibitors. Donepezil 60-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 22534665-1 2012 New series of indole derivatives analogous to donepezil, a well known anti-Alzheimer and acetylcholinesterase inhibitor drug, was synthesized. indole 14-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 22534665-1 2012 New series of indole derivatives analogous to donepezil, a well known anti-Alzheimer and acetylcholinesterase inhibitor drug, was synthesized. Donepezil 46-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 22534665-4 2012 Most of the compounds were found to have potent acetylcholinesterase inhibitor activity compared to donepezil as standard. Donepezil 100-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 22520752-4 2012 Our selection for prevention of acetylcholinesterase inhibition also resulted in the complete reversion of PON1"s stereospecificity, from an enantiomeric ratio (E) < 6.3 x 10(-4) in favor of the R(P) isomer of a cyclosarin analog in wild-type PON1, to E > 2,500 for the S(P) isomer in an evolved variant. cyclohexyl methylphosphonofluoridate 215-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 22425563-0 2012 Prospective acetylcholinesterase inhibitory activity of indole and its analogs. indole 56-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 22425563-1 2012 Acetylcholinesterase (AChE) inhibitory activity is one of the proposed targets for indole analogs. indole 83-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 22425563-1 2012 Acetylcholinesterase (AChE) inhibitory activity is one of the proposed targets for indole analogs. indole 83-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 22425563-2 2012 Simple indoles with substitution of methoxy, carboxy or hydroxy at the benzene ring showed a low percent of inhibitory activity in eel-AChE. Benzene 71-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 22425563-5 2012 The result of inhibition in human-AChE of serotonin, beta-carbolines and quinolines showed similar profile as eel-AChE with lower magnitude. Serotonin 42-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 22425563-5 2012 The result of inhibition in human-AChE of serotonin, beta-carbolines and quinolines showed similar profile as eel-AChE with lower magnitude. Serotonin 42-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 22425563-5 2012 The result of inhibition in human-AChE of serotonin, beta-carbolines and quinolines showed similar profile as eel-AChE with lower magnitude. Carbolines 53-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 22425563-5 2012 The result of inhibition in human-AChE of serotonin, beta-carbolines and quinolines showed similar profile as eel-AChE with lower magnitude. Quinolines 73-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 22444876-0 2012 Design, synthesis and evaluation of isaindigotone derivatives as dual inhibitors for acetylcholinesterase and amyloid beta aggregation. isaindigotone 36-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 22444876-2 2012 The synthetic compounds had IC(50) values at micro or nano molar range for cholinesterase inhibition, and some compounds exhibited strong inhibitory activity for AChE and high selectivity for AChE over BuChE, which were much better than the isaindigotone derivatives previously reported by our group. isaindigotone 241-254 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-166 22444876-2 2012 The synthetic compounds had IC(50) values at micro or nano molar range for cholinesterase inhibition, and some compounds exhibited strong inhibitory activity for AChE and high selectivity for AChE over BuChE, which were much better than the isaindigotone derivatives previously reported by our group. isaindigotone 241-254 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 22445674-3 2012 Purification of the methanol extract of Paulownia tomentosa fruits yielded potent hAChE and BChE inhibitory flavonoids (1-9). Methanol 20-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-87 22445674-6 2012 IC(50)s of diplacone (8) were 7.2 muM for hAChE and 1.4 muM for BChE. diplacone 11-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-47 22404254-3 2012 Moreover, the spherical aggregates can be disassembled triggered by acetylcholinesterase, an enzyme which can cut off the ester linkage of myristoylcholine chloride. Myristoylcholine chloride 139-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 22404254-4 2012 Nile red can be loaded into the spherical aggregates and released in several hours upon the treatment of acetylcholinesterase. nile red 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 22343626-1 2012 We present a systematic structural optimization of uncharged but ionizable N-substituted 2-hydroxyiminoacetamido alkylamine reactivators of phosphylated human acetylcholinesterase (hAChE) intended to catalyze the hydrolysis of organophosphate (OP)-inhibited hAChE in the CNS. Nitrogen 75-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-186 22343626-1 2012 We present a systematic structural optimization of uncharged but ionizable N-substituted 2-hydroxyiminoacetamido alkylamine reactivators of phosphylated human acetylcholinesterase (hAChE) intended to catalyze the hydrolysis of organophosphate (OP)-inhibited hAChE in the CNS. Nitrogen 75-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 258-263 22343626-1 2012 We present a systematic structural optimization of uncharged but ionizable N-substituted 2-hydroxyiminoacetamido alkylamine reactivators of phosphylated human acetylcholinesterase (hAChE) intended to catalyze the hydrolysis of organophosphate (OP)-inhibited hAChE in the CNS. substituted 2-hydroxyiminoacetamido alkylamine 77-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-186 22343626-1 2012 We present a systematic structural optimization of uncharged but ionizable N-substituted 2-hydroxyiminoacetamido alkylamine reactivators of phosphylated human acetylcholinesterase (hAChE) intended to catalyze the hydrolysis of organophosphate (OP)-inhibited hAChE in the CNS. substituted 2-hydroxyiminoacetamido alkylamine 77-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 258-263 22343626-1 2012 We present a systematic structural optimization of uncharged but ionizable N-substituted 2-hydroxyiminoacetamido alkylamine reactivators of phosphylated human acetylcholinesterase (hAChE) intended to catalyze the hydrolysis of organophosphate (OP)-inhibited hAChE in the CNS. Organophosphates 227-242 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-186 22343626-2 2012 Starting with the initial lead oxime RS41A identified in our earlier study and extending to the azepine analog RS194B, reactivation rates for OP-hAChE conjugates formed by sarin, cyclosarin, VX, paraoxon, and tabun are enhanced severalfold in vitro. Oximes 31-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-150 22343626-2 2012 Starting with the initial lead oxime RS41A identified in our earlier study and extending to the azepine analog RS194B, reactivation rates for OP-hAChE conjugates formed by sarin, cyclosarin, VX, paraoxon, and tabun are enhanced severalfold in vitro. Azepines 96-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-150 22343626-2 2012 Starting with the initial lead oxime RS41A identified in our earlier study and extending to the azepine analog RS194B, reactivation rates for OP-hAChE conjugates formed by sarin, cyclosarin, VX, paraoxon, and tabun are enhanced severalfold in vitro. cyclohexyl methylphosphonofluoridate 179-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-150 22343626-2 2012 Starting with the initial lead oxime RS41A identified in our earlier study and extending to the azepine analog RS194B, reactivation rates for OP-hAChE conjugates formed by sarin, cyclosarin, VX, paraoxon, and tabun are enhanced severalfold in vitro. VX 191-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-150 22343626-2 2012 Starting with the initial lead oxime RS41A identified in our earlier study and extending to the azepine analog RS194B, reactivation rates for OP-hAChE conjugates formed by sarin, cyclosarin, VX, paraoxon, and tabun are enhanced severalfold in vitro. Paraoxon 195-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-150 22343626-2 2012 Starting with the initial lead oxime RS41A identified in our earlier study and extending to the azepine analog RS194B, reactivation rates for OP-hAChE conjugates formed by sarin, cyclosarin, VX, paraoxon, and tabun are enhanced severalfold in vitro. tabun 209-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-150 22245641-1 2012 Acetylcholinesterase inhibitors (AChEIs), such as donepezil, have been shown to improve cognition in mild to moderate Alzheimer"s disease (AD) patients. Donepezil 50-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21666432-0 2012 Greater responsiveness to donepezil in Alzheimer patients with higher levels of acetylcholinesterase based on attention task scores and a donepezil PET study. Donepezil 26-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 21666432-0 2012 Greater responsiveness to donepezil in Alzheimer patients with higher levels of acetylcholinesterase based on attention task scores and a donepezil PET study. Donepezil 138-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 22475016-2 2012 The detection mechanism is based on the fact that these pesticides can inhibit the activity of acetylcholinesterase (AChE), thus preventing the generation of thiocholine (which turns the RB-AuNP solutions blue and unquenches the fluorescence of RB simultaneously). Thiocholine 158-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 22475016-2 2012 The detection mechanism is based on the fact that these pesticides can inhibit the activity of acetylcholinesterase (AChE), thus preventing the generation of thiocholine (which turns the RB-AuNP solutions blue and unquenches the fluorescence of RB simultaneously). Thiocholine 158-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 22475016-2 2012 The detection mechanism is based on the fact that these pesticides can inhibit the activity of acetylcholinesterase (AChE), thus preventing the generation of thiocholine (which turns the RB-AuNP solutions blue and unquenches the fluorescence of RB simultaneously). rb-aunp 187-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 22475016-2 2012 The detection mechanism is based on the fact that these pesticides can inhibit the activity of acetylcholinesterase (AChE), thus preventing the generation of thiocholine (which turns the RB-AuNP solutions blue and unquenches the fluorescence of RB simultaneously). rb-aunp 187-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 22475016-2 2012 The detection mechanism is based on the fact that these pesticides can inhibit the activity of acetylcholinesterase (AChE), thus preventing the generation of thiocholine (which turns the RB-AuNP solutions blue and unquenches the fluorescence of RB simultaneously). Rubidium 187-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 22475016-2 2012 The detection mechanism is based on the fact that these pesticides can inhibit the activity of acetylcholinesterase (AChE), thus preventing the generation of thiocholine (which turns the RB-AuNP solutions blue and unquenches the fluorescence of RB simultaneously). Rubidium 187-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 22472046-2 2012 Compound 44b, tacrine linked with phenyl-benzothiazole by 3-carbon spacers, was the most potent AChE inhibitor with an IC(50) value of 0.017 muM. Tacrine 14-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 22472693-2 2012 Previously our group has reported a series of tacrine-based hybrids as potent AChE inhibitors (AChEI). Tacrine 46-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 21850569-2 2012 We have demonstrated the process of reactivating the VX-AChE adduct with formoximate and hydroxylamine anions by applying the DFT approach at the B3LYP/6-311 G(d,p) level of theory. formoximate 73-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 21850569-2 2012 We have demonstrated the process of reactivating the VX-AChE adduct with formoximate and hydroxylamine anions by applying the DFT approach at the B3LYP/6-311 G(d,p) level of theory. Hydroxylamine 89-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 21850569-3 2012 The calculated results suggest that the hydroxylamine anion is more efficient than the formoximate anion at reactivating VX-inhibited AChE. hydroxylamine anion 40-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 21850569-3 2012 The calculated results suggest that the hydroxylamine anion is more efficient than the formoximate anion at reactivating VX-inhibited AChE. formoximate anion 87-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 21850569-4 2012 The reaction of formoximate anion and the VX-AChE adduct is a three-step process, while the reaction of hydroxylamine anion with the VX-AChE adduct seems to be a two-step process. formoximate anion 16-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 21850569-4 2012 The reaction of formoximate anion and the VX-AChE adduct is a three-step process, while the reaction of hydroxylamine anion with the VX-AChE adduct seems to be a two-step process. hydroxylamine anion 104-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 21850569-7 2012 The potential energy surface (PES) for the reaction of the VX-AChE adduct with hydroxylamine anion reveals that the reactivation process is facilitated by the lower free energy of activation (by a factor of 1.7 kcal mol(-1)) than that of the formoximate anion at the B3LYP/6-311 G(d,p) level of theory. hydroxylamine anion 79-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 21850569-7 2012 The potential energy surface (PES) for the reaction of the VX-AChE adduct with hydroxylamine anion reveals that the reactivation process is facilitated by the lower free energy of activation (by a factor of 1.7 kcal mol(-1)) than that of the formoximate anion at the B3LYP/6-311 G(d,p) level of theory. formoximate anion 242-259 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 21850569-9 2012 The activation barriers calculated in solvent using the polarizable continuum model (PCM) for the reactivation of the VX-AChE adduct with hydroxylamine anion were also found to be low. hydroxylamine anion 138-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 22280344-5 2012 This review summarizes the literature data that support the hypothesis that an insect-specific cysteine residue located at the opening of the acetylcholinesterase active site is a promising target site for developing new insecticides with reduced off-target toxicity and low propensity for insect resistance. Cysteine 95-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 22280344-6 2012 These data are used to discuss the differences between targeting the insect-specific cysteine residue and targeting the ubiquitous catalytic serine residue of acetylcholinesterase from the perspective of reducing off-target toxicity and insect resistance. Serine 141-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 22280346-1 2012 Acetylcholinesterase (AChE; EC 3.1.1.7) is a primary target of many insecticides including organophosphates (OP) and carbamates (CB). Organophosphates 91-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 22280346-1 2012 Acetylcholinesterase (AChE; EC 3.1.1.7) is a primary target of many insecticides including organophosphates (OP) and carbamates (CB). Organophosphates 91-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 22280346-1 2012 Acetylcholinesterase (AChE; EC 3.1.1.7) is a primary target of many insecticides including organophosphates (OP) and carbamates (CB). Carbamates 117-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 22280346-1 2012 Acetylcholinesterase (AChE; EC 3.1.1.7) is a primary target of many insecticides including organophosphates (OP) and carbamates (CB). Carbamates 117-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 22594259-1 2012 A series of novel N-benzyl substituted amides of 1H-indole-5-carboxylic acid were synthesized and evaluated for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). n-benzyl substituted amides 18-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 22594259-1 2012 A series of novel N-benzyl substituted amides of 1H-indole-5-carboxylic acid were synthesized and evaluated for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Indole-5-carboxylic acid 49-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 22594259-1 2012 A series of novel N-benzyl substituted amides of 1H-indole-5-carboxylic acid were synthesized and evaluated for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Indole-5-carboxylic acid 49-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 22245562-2 2012 It aims to compensate for the deficit in cholinergic neurotransmission by blocking acetylcholinesterase (AChE) and thus increases the concentration of extracellular acetylcholine. Acetylcholine 83-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 22339669-3 2012 We describe a method using acetylcholinesterase (AChE) to modulate the distance between a gold nanoparticle (AuNP) and the fluorophore 7-hydroxy-9H-(1,3-dichloro-9,9-dimethylacridin-2-one) (DDAO). 7-hydroxy-9h-(1,3-dichloro-9,9-dimethylacridin-2-one 135-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 22247004-4 2012 NEMP, PIMP, and NIMP were potent inhibitors of rat brain, skeletal muscle, diaphragm, and serum AChE as well as human erythrocyte AChE and serum BuChE in vitro. nemp 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 22247004-4 2012 NEMP, PIMP, and NIMP were potent inhibitors of rat brain, skeletal muscle, diaphragm, and serum AChE as well as human erythrocyte AChE and serum BuChE in vitro. pimp 6-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 22247004-4 2012 NEMP, PIMP, and NIMP were potent inhibitors of rat brain, skeletal muscle, diaphragm, and serum AChE as well as human erythrocyte AChE and serum BuChE in vitro. nimp 16-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 22339669-3 2012 We describe a method using acetylcholinesterase (AChE) to modulate the distance between a gold nanoparticle (AuNP) and the fluorophore 7-hydroxy-9H-(1,3-dichloro-9,9-dimethylacridin-2-one) (DDAO). 7-hydroxy-9h-(1,3-dichloro-9,9-dimethylacridin-2-one 135-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 22339669-3 2012 We describe a method using acetylcholinesterase (AChE) to modulate the distance between a gold nanoparticle (AuNP) and the fluorophore 7-hydroxy-9H-(1,3-dichloro-9,9-dimethylacridin-2-one) (DDAO). DDAO 190-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 22339669-3 2012 We describe a method using acetylcholinesterase (AChE) to modulate the distance between a gold nanoparticle (AuNP) and the fluorophore 7-hydroxy-9H-(1,3-dichloro-9,9-dimethylacridin-2-one) (DDAO). DDAO 190-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 22339669-4 2012 We found that DDAO is a reversible mixed type-I AChE inhibitor. DDAO 14-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 22339669-5 2012 DDAO binds to the peripheral anionic site and penetrates into the active gorge site of AChE via inhibition kinetics test and molecular docking study. DDAO 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 22339669-6 2012 The affinity ligand DDAO bound to AChE which was immobilized onto AuNPs, and its fluorescence was sharply enhanced due to MEF. DDAO 20-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 22339669-7 2012 The fluorescence was reduced by distance variations between the AuNP and DDAO, which resulted from other inhibitors competitively binding with AChE and partly or completely displacing DDAO. DDAO 73-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 22448158-5 2012 This signaling process is terminated when ACh is hydrolyzed by acetylcholinesterase (AChE). Acetylcholine 42-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 22448158-5 2012 This signaling process is terminated when ACh is hydrolyzed by acetylcholinesterase (AChE). Acetylcholine 42-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 22448158-7 2012 Intriguingly, the effects of stress and AChE variants on hematopoietic development and inflammation in health and disease are both subject to small molecule as well as oligonucleotide-mediated manipulations in vitro and in vivo. Oligonucleotides 168-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 22341944-0 2012 Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. oxoisoaporphine 6-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 22230694-0 2012 Amperometric acetylcholine biosensor based on self-assembly of gold nanoparticles and acetylcholinesterase on the sol-gel/multi-walled carbon nanotubes/choline oxidase composite-modified platinum electrode. Acetylcholine 13-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 22230694-0 2012 Amperometric acetylcholine biosensor based on self-assembly of gold nanoparticles and acetylcholinesterase on the sol-gel/multi-walled carbon nanotubes/choline oxidase composite-modified platinum electrode. Carbon 135-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 22230694-0 2012 Amperometric acetylcholine biosensor based on self-assembly of gold nanoparticles and acetylcholinesterase on the sol-gel/multi-walled carbon nanotubes/choline oxidase composite-modified platinum electrode. Platinum 187-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 22230694-1 2012 A novel acetylcholinesterase (AChE)/choline oxidase (ChOx) bienzyme amperometric acetylcholine biosensor based on gold nanoparticles (AuNPs) and multi-walled carbon nanotubes (MWCNTs) has been successfully developed by self-assembly process in combination of sol-gel technique. Acetylcholine 8-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 22230694-1 2012 A novel acetylcholinesterase (AChE)/choline oxidase (ChOx) bienzyme amperometric acetylcholine biosensor based on gold nanoparticles (AuNPs) and multi-walled carbon nanotubes (MWCNTs) has been successfully developed by self-assembly process in combination of sol-gel technique. Carbon 158-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-28 22230694-1 2012 A novel acetylcholinesterase (AChE)/choline oxidase (ChOx) bienzyme amperometric acetylcholine biosensor based on gold nanoparticles (AuNPs) and multi-walled carbon nanotubes (MWCNTs) has been successfully developed by self-assembly process in combination of sol-gel technique. Carbon 158-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 22230694-3 2012 Finally, the alternate deposition of poly (diallyldimethylammonium chloride) (PDDA) and AChE was repeated to assemble different layers of PDDA-AChE on the electrode for optimizing AChE loading. poly-N,N-dimethyl-N,N-diallylammonium chloride 37-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 22230694-3 2012 Finally, the alternate deposition of poly (diallyldimethylammonium chloride) (PDDA) and AChE was repeated to assemble different layers of PDDA-AChE on the electrode for optimizing AChE loading. poly-N,N-dimethyl-N,N-diallylammonium chloride 37-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 22341944-1 2012 A series of novel oxoisoaporphine-based inhibitors (10-aminoalkylamino-1-azabenzanthrone Ar-NH(CH(2))(n)NR(1)R(2)) of acetylcholinesterase (AChE) has been designed, synthesized, and tested for their ability to inhibit AChE, butyrylcholinesterase (BChE) and AChE-induced beta-amyloid (Abeta) aggregation. oxoisoaporphine 18-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 22341944-1 2012 A series of novel oxoisoaporphine-based inhibitors (10-aminoalkylamino-1-azabenzanthrone Ar-NH(CH(2))(n)NR(1)R(2)) of acetylcholinesterase (AChE) has been designed, synthesized, and tested for their ability to inhibit AChE, butyrylcholinesterase (BChE) and AChE-induced beta-amyloid (Abeta) aggregation. oxoisoaporphine 18-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 22230694-3 2012 Finally, the alternate deposition of poly (diallyldimethylammonium chloride) (PDDA) and AChE was repeated to assemble different layers of PDDA-AChE on the electrode for optimizing AChE loading. 1,3-Propanediol diacrylate 78-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 22341944-1 2012 A series of novel oxoisoaporphine-based inhibitors (10-aminoalkylamino-1-azabenzanthrone Ar-NH(CH(2))(n)NR(1)R(2)) of acetylcholinesterase (AChE) has been designed, synthesized, and tested for their ability to inhibit AChE, butyrylcholinesterase (BChE) and AChE-induced beta-amyloid (Abeta) aggregation. oxoisoaporphine 18-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 218-222 22230694-3 2012 Finally, the alternate deposition of poly (diallyldimethylammonium chloride) (PDDA) and AChE was repeated to assemble different layers of PDDA-AChE on the electrode for optimizing AChE loading. 1,3-Propanediol diacrylate 78-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 22341944-1 2012 A series of novel oxoisoaporphine-based inhibitors (10-aminoalkylamino-1-azabenzanthrone Ar-NH(CH(2))(n)NR(1)R(2)) of acetylcholinesterase (AChE) has been designed, synthesized, and tested for their ability to inhibit AChE, butyrylcholinesterase (BChE) and AChE-induced beta-amyloid (Abeta) aggregation. 10-aminoalkylamino-1-azabenzanthrone 52-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 22341944-1 2012 A series of novel oxoisoaporphine-based inhibitors (10-aminoalkylamino-1-azabenzanthrone Ar-NH(CH(2))(n)NR(1)R(2)) of acetylcholinesterase (AChE) has been designed, synthesized, and tested for their ability to inhibit AChE, butyrylcholinesterase (BChE) and AChE-induced beta-amyloid (Abeta) aggregation. 10-aminoalkylamino-1-azabenzanthrone 52-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 22341944-1 2012 A series of novel oxoisoaporphine-based inhibitors (10-aminoalkylamino-1-azabenzanthrone Ar-NH(CH(2))(n)NR(1)R(2)) of acetylcholinesterase (AChE) has been designed, synthesized, and tested for their ability to inhibit AChE, butyrylcholinesterase (BChE) and AChE-induced beta-amyloid (Abeta) aggregation. 10-aminoalkylamino-1-azabenzanthrone 52-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 218-222 22483282-0 2012 Molecular interaction of the antineoplastic drug, methotrexate with human brain acetylcholinesterase: a docking study. Methotrexate 50-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 22230262-0 2012 Comparative kinetics of organophosphates and oximes with erythrocyte, muscle and brain acetylcholinesterase. Organophosphates 24-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 22230262-0 2012 Comparative kinetics of organophosphates and oximes with erythrocyte, muscle and brain acetylcholinesterase. Oximes 45-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 22230262-1 2012 There is an ongoing debate whether oximes can effectively counteract the effects of organophosphorus compounds (OP) on brain acetylcholinesterase (AChE) activity and whether there are differences in the kinetic properties of brain and erythrocyte AChE. Oximes 35-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 22230262-1 2012 There is an ongoing debate whether oximes can effectively counteract the effects of organophosphorus compounds (OP) on brain acetylcholinesterase (AChE) activity and whether there are differences in the kinetic properties of brain and erythrocyte AChE. Oximes 35-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 22230262-7 2012 These data support the view that AChE from different tissue has similar kinetic properties and that brain AChE is comparably susceptible toward reactivation by oximes. Oximes 160-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 21989769-0 2012 Synthesis and acetylcholinesterase and butyrylcholinesterase inhibitory activities of 7-alkoxyl substituted indolizinoquinoline-5,12-dione derivatives. 7-alkoxyl substituted indolizinoquinoline-5,12-dione 86-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 21989769-4 2012 Kinetic study of AChE indicated that a mixed type of inhibition pattern existed for these indolizinoquinoline-5,12-dione derivatives. indolizinoquinoline-5,12-dione 90-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 22483282-1 2012 This study describes molecular interactions between human brain acetylcholinesterase (AChE) and the well known anti-neoplastic drug, methotrexate (MTX) and its comparison to "AChE-cyclophosphamide (CP) interactions" that we reported previously. Methotrexate 133-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 22483282-1 2012 This study describes molecular interactions between human brain acetylcholinesterase (AChE) and the well known anti-neoplastic drug, methotrexate (MTX) and its comparison to "AChE-cyclophosphamide (CP) interactions" that we reported previously. Methotrexate 133-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 22483282-1 2012 This study describes molecular interactions between human brain acetylcholinesterase (AChE) and the well known anti-neoplastic drug, methotrexate (MTX) and its comparison to "AChE-cyclophosphamide (CP) interactions" that we reported previously. Methotrexate 147-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 22483282-1 2012 This study describes molecular interactions between human brain acetylcholinesterase (AChE) and the well known anti-neoplastic drug, methotrexate (MTX) and its comparison to "AChE-cyclophosphamide (CP) interactions" that we reported previously. Methotrexate 147-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 22483282-1 2012 This study describes molecular interactions between human brain acetylcholinesterase (AChE) and the well known anti-neoplastic drug, methotrexate (MTX) and its comparison to "AChE-cyclophosphamide (CP) interactions" that we reported previously. Cyclophosphamide 180-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 175-179 22483282-2 2012 Docking between MTX and AChE was performed using "Autodock4.2". Methotrexate 16-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 22483282-5 2012 Such information may aid in the design of versatile AChE-inhibitors, and is expected to aid in safe clinical use of MTX. Methotrexate 116-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 22483282-6 2012 Scope still remains in the determination of the three-dimensional structure of AChE-MTX complex by X-ray crystallography to validate the described data. Methotrexate 84-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 22483282-7 2012 The current computational study supports our previous experimental study which concluded a mixed inhibition model for AChE-inhibition by MTX. Methotrexate 137-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 22483282-8 2012 Furthermore, the present report confirms that MTX is a more efficient inhibitor of human brain AChE compared to CP with reference to K(i) and DeltaG values. Methotrexate 46-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 21998030-0 2012 Determination of acetylcholinesterase activity by the Ellman assay: a versatile tool for in vitro research on medical countermeasures against organophosphate poisoning. Organophosphates 142-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 21998030-1 2012 Inhibition of acetylcholinesterase (AChE) is the main mechanism of action of organophosphorus compounds (OP), and AChE reactivators (oximes) are at present the only causal therapeutic approach. Organophosphorus Compounds 77-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 21998030-1 2012 Inhibition of acetylcholinesterase (AChE) is the main mechanism of action of organophosphorus compounds (OP), and AChE reactivators (oximes) are at present the only causal therapeutic approach. Organophosphorus Compounds 77-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 21998030-2 2012 Being the key target of OP toxicity, AChE may serve as a valuable tool for diagnosis of OP exposure as well as for the investigation of the kinetics of interactions between OP and oximes. Oximes 180-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 22447833-1 2012 Oxime HI-6 is an efficient reactivator of the acetylcholinesterase inhibited by organophosphorous nerve agents. Oximes 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 22447833-1 2012 Oxime HI-6 is an efficient reactivator of the acetylcholinesterase inhibited by organophosphorous nerve agents. asoxime chloride 6-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 22427467-4 2012 The goal of our study was to examine donepezil - an acetylcholinesterase inhibitor (AChEI) currently used in AD therapy -, and to what degree it influences the serum adipokine levels and metabolic parameters of AD patients. Donepezil 37-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 22309910-1 2012 We earlier reported an in silico pharmacophore model for reactivation of oximes to tabun-inhibited AChE. Oximes 73-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 22309910-2 2012 Since DFP (diisopropylfluorophosphate) like tabun is a G-agent simulator, we utilized the model as a rational strategy to discover non-oxime reactivators of DFP-inhibited AChE in this study. Isoflurophate 11-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 22309910-2 2012 Since DFP (diisopropylfluorophosphate) like tabun is a G-agent simulator, we utilized the model as a rational strategy to discover non-oxime reactivators of DFP-inhibited AChE in this study. Oximes 135-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 22309910-4 2012 The procedure led us to identify several potent non-oxime compounds that reactivate DFP-inhibited AChE. Oximes 52-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 22160193-2 2012 Taxifolin inhibits the production of lipopolysaccharide-induced prostaglandin E, and fustin suppresses the activity of acetylcholinesterase. fustin 97-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 21922192-1 2012 Chlorpyrifos (CPF), an organophosphate pesticide inhibits acetylcholinesterase (AChE) and causes neuromuscular incoordination among children and elderly. Chlorpyrifos 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 21922192-1 2012 Chlorpyrifos (CPF), an organophosphate pesticide inhibits acetylcholinesterase (AChE) and causes neuromuscular incoordination among children and elderly. Chlorpyrifos 14-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 21530001-7 2012 This study is the first direct evidence of a modulatory effect of P-tau on brain AChE expression. p-tau 66-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 21621296-3 2012 Treatment of SH-SY5Y cells with the AChE-inhibitor tacrine decreased PS1 levels, in parallel with increase in the secretion of amyloid precursor protein APPalpha, whereas the cholinergic agonist carbachol had no effect on PS1. Tacrine 51-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 21901320-2 2012 OBJECTIVE: Preclinical and clinical experiments were designed to examine the utility of the scopolamine-induced cognitive impairment model in predicting pharmacodynamic signals of putatively procognitive compounds, utilizing the acetylcholinesterase inhibitor donepezil for illustration. Donepezil 260-269 acetylcholinesterase (Cartwright blood group) Homo sapiens 229-249 20641273-3 2004 Acetylcholinesterase (AChE) is the enzyme that terminates cholinergic actions through the rapid hydrolysis of acetylcholine to choline and acetate. Acetylcholine 110-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 20641273-3 2004 Acetylcholinesterase (AChE) is the enzyme that terminates cholinergic actions through the rapid hydrolysis of acetylcholine to choline and acetate. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 20641273-3 2004 Acetylcholinesterase (AChE) is the enzyme that terminates cholinergic actions through the rapid hydrolysis of acetylcholine to choline and acetate. Acetates 139-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 20641273-3 2004 Acetylcholinesterase (AChE) is the enzyme that terminates cholinergic actions through the rapid hydrolysis of acetylcholine to choline and acetate. Acetates 139-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 20641273-9 2004 [(11)C]PMP is specifically hydrolyzed by AChE (86-95% specificity) and yields a hydrophilic metabolite, N-[(11)C]methylpiperidinol ([(11)C]MP4OH), which is trapped in the brain because it cannot cross the BBB. pmp 7-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 20641273-9 2004 [(11)C]PMP is specifically hydrolyzed by AChE (86-95% specificity) and yields a hydrophilic metabolite, N-[(11)C]methylpiperidinol ([(11)C]MP4OH), which is trapped in the brain because it cannot cross the BBB. n-[(11)c]methylpiperidinol 104-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 20641273-9 2004 [(11)C]PMP is specifically hydrolyzed by AChE (86-95% specificity) and yields a hydrophilic metabolite, N-[(11)C]methylpiperidinol ([(11)C]MP4OH), which is trapped in the brain because it cannot cross the BBB. mp4oh 139-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 20641273-11 2004 [(11)C]PMP is being developed as a PET agent for the non-invasive study of brain AChE activity in patients with AD and PD. pmp 7-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 22177963-1 2012 Acute organophosphate (OP) intoxication is important because of its high morbidity and mortality and occurrence of muscular paralysis associated by inhibition of acetylcholinesterase (AChE) activity at the neuromuscular junction. Organophosphates 6-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-182 20641273-3 2004 Acetylcholinesterase (AChE) is the enzyme that terminates cholinergic actions through the rapid hydrolysis of acetylcholine to choline and acetate. Acetylcholine 110-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 22374313-0 2012 Synthesis, characterization, X-ray crystallography, acetyl cholinesterase inhibition and antioxidant activities of some novel ketone derivatives of gallic hydrazide-derived Schiff bases. Ketones 126-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-73 22374313-0 2012 Synthesis, characterization, X-ray crystallography, acetyl cholinesterase inhibition and antioxidant activities of some novel ketone derivatives of gallic hydrazide-derived Schiff bases. gallic hydrazide-derived schiff bases 148-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-73 22374313-6 2012 N-(1-(5-bromo-2-hydroxyphenyl)-ethylidene)-3,4,5-trihydroxybenzohydrazide (2) was the most potent inhibitor of human acetyl cholinesterase, giving an inhibition rate of 77% at 100 muM. n-(1-(5-bromo-2-hydroxyphenyl)-ethylidene)-3,4,5-trihydroxybenzohydrazide 0-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-138 22198100-4 2012 This work aimed to evaluate, in blood and brain samples from hens, human blood, and human cell culture samples, the potential of the enantiomeric forms of methamidophos to induce acetylcholinesterase (AChE) inhibition and/or delayed neurotoxicity. methamidophos 155-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 179-199 22198100-4 2012 This work aimed to evaluate, in blood and brain samples from hens, human blood, and human cell culture samples, the potential of the enantiomeric forms of methamidophos to induce acetylcholinesterase (AChE) inhibition and/or delayed neurotoxicity. methamidophos 155-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 201-205 20641824-3 2004 Acetylcholinesterase (AChE) is the enzyme that terminates cholinergic actions through the rapid hydrolysis of acetylcholine to choline and acetate. Acetylcholine 110-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 20641824-3 2004 Acetylcholinesterase (AChE) is the enzyme that terminates cholinergic actions through the rapid hydrolysis of acetylcholine to choline and acetate. Acetylcholine 110-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 20641824-3 2004 Acetylcholinesterase (AChE) is the enzyme that terminates cholinergic actions through the rapid hydrolysis of acetylcholine to choline and acetate. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 20641824-3 2004 Acetylcholinesterase (AChE) is the enzyme that terminates cholinergic actions through the rapid hydrolysis of acetylcholine to choline and acetate. Acetates 139-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 20641824-3 2004 Acetylcholinesterase (AChE) is the enzyme that terminates cholinergic actions through the rapid hydrolysis of acetylcholine to choline and acetate. Acetates 139-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 20641824-6 2004 Radiolabeled AChE inhibitors and acetylcholine analog substrates are the two major approaches to mapping AChE in vivo in the human brain. Acetylcholine 33-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 20641824-10 2004 [(11)C]MP4A is specifically hydrolyzed by AChE (99% specificity) and yields a hydrophilic metabolite, N-[(11)C]methylpiperidinol ([(11)C]MP4OH), which is trapped in the brain because it is too polar to cross the BBB. n-[(11)c]methylpiperidinol 102-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 22200647-3 2012 The question of whether ibogaine inhibits acetylcholinesterase (AChE) is of pharmacological and toxicological significance. Ibogaine 24-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 22200647-3 2012 The question of whether ibogaine inhibits acetylcholinesterase (AChE) is of pharmacological and toxicological significance. Ibogaine 24-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 22200647-4 2012 MATERIALS AND METHODS: AChE activity was evaluated utilizing reaction with Ellman"s reagent with physostigmine as a control. Physostigmine 97-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 22200647-5 2012 RESULTS: Ibogaine inhibited AChE with an IC(50) of 520+-40 muM. Ibogaine 9-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 22200647-6 2012 CONCLUSIONS: Ibogaine"s inhibition of AChE is physiologically negligible, and does not appear to account for observations of functional effects in animals and humans that might otherwise suggest the possible involvement of pathways linked to muscarinic acetylcholine transmission. Ibogaine 13-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 26596618-1 2012 Acetylcholinesterase is an enzyme with a very high turnover rate; it quenches the neurotransmitter, acetylcholine, at the synapse. Acetylcholine 100-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 22208309-0 2012 Highly sensitive and selective immuno-capture/electrochemical assay of acetylcholinesterase activity in red blood cells: a biomarker of exposure to organophosphorus pesticides and nerve agents. organophosphorus 148-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 22208309-1 2012 Acetylcholinesterase (AChE) enzyme activity in red blood cells (RBCs) is a useful biomarker for biomonitoring of exposures to organophosphorus (OP) pesticides and chemical nerve agents. organophosphorus 126-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 22037292-3 2012 The response was linear over an ACh concentration range of 1x10(-6) to 1x10(-3) M with a slope of 59.1+-0.1 and a detection limit of 1.5x10(-7)+-1.2x10(-8) M. The electrode was used to monitor enzymatic ACh hydrolysis catalyzed by acetylcholinesterase (AChE) at different substrate and enzyme concentrations. Acetylcholine 32-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 231-251 22037292-3 2012 The response was linear over an ACh concentration range of 1x10(-6) to 1x10(-3) M with a slope of 59.1+-0.1 and a detection limit of 1.5x10(-7)+-1.2x10(-8) M. The electrode was used to monitor enzymatic ACh hydrolysis catalyzed by acetylcholinesterase (AChE) at different substrate and enzyme concentrations. Acetylcholine 32-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 253-257 21880553-2 2012 An acetylcholinesterase (AChE) based amperometric biosensor was developed by silica sol-gel film immobilization of the enzyme onto the carbon paste electrode. Silicon Dioxide 77-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 21880553-2 2012 An acetylcholinesterase (AChE) based amperometric biosensor was developed by silica sol-gel film immobilization of the enzyme onto the carbon paste electrode. Carbon 135-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 22037997-7 2012 Often, acetylcholinesterase inhibitors such as pyridostigmine and neostigmine are also employed to help control symptoms. Pyridostigmine Bromide 47-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 7-27 22037997-7 2012 Often, acetylcholinesterase inhibitors such as pyridostigmine and neostigmine are also employed to help control symptoms. Neostigmine 66-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 7-27 22037997-8 2012 When steroids are contraindicated, acetylcholinesterase inhibitors can be tried as the primary therapy. Steroids 5-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 22451057-1 2012 A capillary zone electrophoresis-electrospray ionization-mass spectrometry (CZE-ESI-MS) method was developed for the analysis of the acetylcholinesterase inhibitor rivastigmine. Rivastigmine 164-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 22379573-1 2012 BACKGROUND: Soman, a potent irreversible acetylcholinesterase (AChE) inhibitor, induces delayed neuronal injury by reactive oxygen species (ROS). Reactive Oxygen Species 115-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 22379573-1 2012 BACKGROUND: Soman, a potent irreversible acetylcholinesterase (AChE) inhibitor, induces delayed neuronal injury by reactive oxygen species (ROS). Reactive Oxygen Species 140-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 22032870-3 2012 The structure of tacrine, an acetylcholinesterase (AChE) inhibitor (AChEI), has been widely used as scaffold to provide new MTDLs. Tacrine 17-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 22032870-3 2012 The structure of tacrine, an acetylcholinesterase (AChE) inhibitor (AChEI), has been widely used as scaffold to provide new MTDLs. Tacrine 17-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 22032870-6 2012 In this study we demonstrated that the cystamine-tacrine dimer is endowed with a lower toxicity in comparison to bis(7)tacrine, it is able to inhibit AChE, butyrylcholinesterase (BChE), self- and AChE-induced beta-amyloid aggregation in the same range of the reference compound and exerts a neuroprotective action on SH-SY5Y cell line against H(2)O(2)-induced oxidative injury. Cystamine 39-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 22032870-6 2012 In this study we demonstrated that the cystamine-tacrine dimer is endowed with a lower toxicity in comparison to bis(7)tacrine, it is able to inhibit AChE, butyrylcholinesterase (BChE), self- and AChE-induced beta-amyloid aggregation in the same range of the reference compound and exerts a neuroprotective action on SH-SY5Y cell line against H(2)O(2)-induced oxidative injury. Cystamine 39-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 196-200 22032870-6 2012 In this study we demonstrated that the cystamine-tacrine dimer is endowed with a lower toxicity in comparison to bis(7)tacrine, it is able to inhibit AChE, butyrylcholinesterase (BChE), self- and AChE-induced beta-amyloid aggregation in the same range of the reference compound and exerts a neuroprotective action on SH-SY5Y cell line against H(2)O(2)-induced oxidative injury. Tacrine 49-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 22032870-6 2012 In this study we demonstrated that the cystamine-tacrine dimer is endowed with a lower toxicity in comparison to bis(7)tacrine, it is able to inhibit AChE, butyrylcholinesterase (BChE), self- and AChE-induced beta-amyloid aggregation in the same range of the reference compound and exerts a neuroprotective action on SH-SY5Y cell line against H(2)O(2)-induced oxidative injury. Tacrine 49-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 196-200 21933122-1 2012 Acetylcholinesterase (AChE), a member of the alpha/beta-hydrolase fold superfamily of proteins, is a serine hydrolase responsible for the hydrolysis of the well studied neurotransmitter acetylcholine (ACh). Acetylcholine 186-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21933122-1 2012 Acetylcholinesterase (AChE), a member of the alpha/beta-hydrolase fold superfamily of proteins, is a serine hydrolase responsible for the hydrolysis of the well studied neurotransmitter acetylcholine (ACh). Acetylcholine 186-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 21933122-1 2012 Acetylcholinesterase (AChE), a member of the alpha/beta-hydrolase fold superfamily of proteins, is a serine hydrolase responsible for the hydrolysis of the well studied neurotransmitter acetylcholine (ACh). Acetylcholine 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 22461927-5 2012 DISCUSSION: Atropine causes anticholinergic toxicity; physostigmine reverses this by inhibiting acetylcholinesterase. Physostigmine 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 22006836-4 2012 Each amide derivative was evaluated for its ability to inhibit AChE and BuChE using a modification of Ellman"s spectrophotometric method. Amides 5-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 22257528-0 2012 A review on coumarins as acetylcholinesterase inhibitors for Alzheimer"s disease. Coumarins 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 22257528-2 2012 Coumarins are the phytochemicals with wide range of biological activities including AChE inhibition. Coumarins 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 22257528-3 2012 The scientists have attempted to explore the coumarin template for synthesizing novel AChE inhibitors with additional pharmacological activities including decrease in beta-amyloid (Abeta) deposition and beta-secretase inhibition that are also important for AD management. coumarin 45-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 22257528-5 2012 The present review describes these differently synthesized coumarin derivatives as AChE inhibitors for management of AD. coumarin 59-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 22177963-1 2012 Acute organophosphate (OP) intoxication is important because of its high morbidity and mortality and occurrence of muscular paralysis associated by inhibition of acetylcholinesterase (AChE) activity at the neuromuscular junction. Organophosphates 6-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-188 22148672-0 2012 Acetylcholinesterase liquid crystal biosensor based on modulated growth of gold nanoparticles for amplified detection of acetylcholine and inhibitor. Acetylcholine 121-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 22323348-2 2012 This study was designed to determine the interaction between inhibition of both butyrylcholinesterase (BuChE) and acetylcholinesterase (AChE) with rivastigmine and peripheral insulin resistance (IR) in LOAD. Rivastigmine 147-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 22323348-2 2012 This study was designed to determine the interaction between inhibition of both butyrylcholinesterase (BuChE) and acetylcholinesterase (AChE) with rivastigmine and peripheral insulin resistance (IR) in LOAD. Rivastigmine 147-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 22323348-8 2012 CONCLUSION: In conclusion, inhibition of both BuChE and AChE with rivastigmine was improved the cognition without affecting on the peripheral IR in the elderly patients with LOAD by HOMA. Rivastigmine 66-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 22154168-1 2012 The electrochemical biosensors based on poly(o-phenylenediamine) (PoPD) and acetylcholinesterase (AChE) and choline oxidase (ChO) enzymes were fabricated on carbon fibre (CF) substrate. Carbon 157-163 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 22154168-1 2012 The electrochemical biosensors based on poly(o-phenylenediamine) (PoPD) and acetylcholinesterase (AChE) and choline oxidase (ChO) enzymes were fabricated on carbon fibre (CF) substrate. Carbon 157-163 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 22148672-1 2012 A novel acetylcholinesterase (AChE) liquid crystal (LC) biosensor based on enzymatic growth of gold nanoparticles (Au NPs) has been developed for amplified detection of acetylcholine (ACh) and AChE inhibitor. Acetylcholine 8-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 22148672-1 2012 A novel acetylcholinesterase (AChE) liquid crystal (LC) biosensor based on enzymatic growth of gold nanoparticles (Au NPs) has been developed for amplified detection of acetylcholine (ACh) and AChE inhibitor. Acetylcholine 8-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-197 22148672-1 2012 A novel acetylcholinesterase (AChE) liquid crystal (LC) biosensor based on enzymatic growth of gold nanoparticles (Au NPs) has been developed for amplified detection of acetylcholine (ACh) and AChE inhibitor. Acetylcholine 30-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-28 22148672-1 2012 A novel acetylcholinesterase (AChE) liquid crystal (LC) biosensor based on enzymatic growth of gold nanoparticles (Au NPs) has been developed for amplified detection of acetylcholine (ACh) and AChE inhibitor. Acetylcholine 30-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-197 22148672-2 2012 In this method, AChE mediates the hydrolysis of acetylthiocholine (ATCl) to form thiocholine, and the latter further reduces AuCl(4)(-) to Au NPs without Au nanoseeds. Acetylthiocholine 48-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 22148672-2 2012 In this method, AChE mediates the hydrolysis of acetylthiocholine (ATCl) to form thiocholine, and the latter further reduces AuCl(4)(-) to Au NPs without Au nanoseeds. Acetylthiocholine 67-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 22148672-2 2012 In this method, AChE mediates the hydrolysis of acetylthiocholine (ATCl) to form thiocholine, and the latter further reduces AuCl(4)(-) to Au NPs without Au nanoseeds. Thiocholine 54-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 22148672-4 2012 On the other hand, the hydrolysis of ATCl is inhibited in the presence of ACh or organophosphate pesticides (OPs, a AChE inhibitor), which will decrease the catalytic growth of Au NPs and, as a result, reduce the orientational response of LCs. Acetylthiocholine 37-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 22148672-4 2012 On the other hand, the hydrolysis of ATCl is inhibited in the presence of ACh or organophosphate pesticides (OPs, a AChE inhibitor), which will decrease the catalytic growth of Au NPs and, as a result, reduce the orientational response of LCs. Acetylcholine 74-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 22148672-4 2012 On the other hand, the hydrolysis of ATCl is inhibited in the presence of ACh or organophosphate pesticides (OPs, a AChE inhibitor), which will decrease the catalytic growth of Au NPs and, as a result, reduce the orientational response of LCs. Organophosphates 81-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 22148672-5 2012 On the basis of such an inhibition mechanism, the AChE LC biosensor can be used as an effective way to realize the detection of ACh and AChE inhibitors. Acetylcholine 50-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 22240379-3 2012 Accordingly, the expression of acetylcholinesterase (AChE), the enzyme responsible for ACh hydrolysis, has been observed to be modulated in inflammation. Acetylcholine 53-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 22153708-0 2012 Facile synthesis of oxo-/thioxopyrimidines and tetrazoles C-C linked to sugars as novel non-toxic antioxidant acetylcholinesterase inhibitors. oxo-/thioxopyrimidines 20-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 22153708-0 2012 Facile synthesis of oxo-/thioxopyrimidines and tetrazoles C-C linked to sugars as novel non-toxic antioxidant acetylcholinesterase inhibitors. Tetrazoles 47-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 22153708-0 2012 Facile synthesis of oxo-/thioxopyrimidines and tetrazoles C-C linked to sugars as novel non-toxic antioxidant acetylcholinesterase inhibitors. Sugars 72-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 22379477-4 2012 As hypoglossal nerve activity has been reported to be especially susceptible to cholinergic stimulation and irinotecan can cause cholinergic side effects by binding to and inactivating acetylcholinesterase, we suspect this mechanism to be responsible for irinotecan-induced dysarthria. Irinotecan 108-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 185-205 22379477-4 2012 As hypoglossal nerve activity has been reported to be especially susceptible to cholinergic stimulation and irinotecan can cause cholinergic side effects by binding to and inactivating acetylcholinesterase, we suspect this mechanism to be responsible for irinotecan-induced dysarthria. Irinotecan 255-265 acetylcholinesterase (Cartwright blood group) Homo sapiens 185-205 22729048-4 2012 In the current study, the influence of several common organic solvents (methanol, ethanol, isopropanol, acetone, acetonitrile) on enzymatic activity (hen egg white lysozyme, chitinase, alpha-chymotrypsin, elastase from human neutrophils and porcine pancreas, acetylcholinesterase) was tested. acetonitrile 113-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 259-279 23030612-2 2012 Their mechanism of action is reactivation of acetylcholinesterase (AChE) inhibited by organophosphorus agents. organophosphorus 86-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 22414107-4 2012 Shortage of the neurotransmitters, acetylcholine and butyrylcholine has been demonstrated, and therefore, inhibition of the enzymes; acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) that break down acetylcholine and butyrylcholine has become a standard approach for AD treatment. Acetylcholine 35-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 22414107-4 2012 Shortage of the neurotransmitters, acetylcholine and butyrylcholine has been demonstrated, and therefore, inhibition of the enzymes; acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) that break down acetylcholine and butyrylcholine has become a standard approach for AD treatment. Acetylcholine 35-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 22414107-4 2012 Shortage of the neurotransmitters, acetylcholine and butyrylcholine has been demonstrated, and therefore, inhibition of the enzymes; acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) that break down acetylcholine and butyrylcholine has become a standard approach for AD treatment. butyrylcholine 53-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 22414107-4 2012 Shortage of the neurotransmitters, acetylcholine and butyrylcholine has been demonstrated, and therefore, inhibition of the enzymes; acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) that break down acetylcholine and butyrylcholine has become a standard approach for AD treatment. butyrylcholine 53-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 22414107-4 2012 Shortage of the neurotransmitters, acetylcholine and butyrylcholine has been demonstrated, and therefore, inhibition of the enzymes; acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) that break down acetylcholine and butyrylcholine has become a standard approach for AD treatment. Acetylcholine 133-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 23030612-2 2012 Their mechanism of action is reactivation of acetylcholinesterase (AChE) inhibited by organophosphorus agents. organophosphorus 86-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 23030612-5 2012 The mechanism of OPC poisoning involves phosphorylation of the serine hydroxyl group at the active site of AChE leading to the inactivation of this essential enzyme, which has an important role in neurotransmission. serine hydroxyl 63-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 23030612-6 2012 AChE inhibition results in the accumulation of acetylcholine at cholinergic receptor sites, producing continuous stimulation of cholinergic fibers throughout the central and peripheral nervous systems. Acetylcholine 47-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 23030612-7 2012 Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the standard pyridinium oximes (pralidoxime, trimedoxime, obidoxime, HI-6) and diazepam are used for the treatment of organophosphate poisoning in humans. pyridinium oximes 113-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 23030612-7 2012 Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the standard pyridinium oximes (pralidoxime, trimedoxime, obidoxime, HI-6) and diazepam are used for the treatment of organophosphate poisoning in humans. Obidoxime Chloride 158-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 23030612-7 2012 Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the standard pyridinium oximes (pralidoxime, trimedoxime, obidoxime, HI-6) and diazepam are used for the treatment of organophosphate poisoning in humans. asoxime chloride 169-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 23030612-7 2012 Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the standard pyridinium oximes (pralidoxime, trimedoxime, obidoxime, HI-6) and diazepam are used for the treatment of organophosphate poisoning in humans. Diazepam 179-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 23030612-7 2012 Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the standard pyridinium oximes (pralidoxime, trimedoxime, obidoxime, HI-6) and diazepam are used for the treatment of organophosphate poisoning in humans. Organophosphates 218-233 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 23030618-0 2012 3D MI-DRAGON: new model for the reconstruction of US FDA drug- target network and theoretical-experimental studies of inhibitors of rasagiline derivatives for AChE. rasagiline 132-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 23030618-17 2012 First, we have reported the prediction and pharmacological assay of 22 different rasagiline derivatives with possible AChE inhibitory activity. rasagiline 81-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 22596267-4 2012 Here we assessed AChE activity with [11C]-MP4A and PET by a maximum a posteriori Bayesian method (MAPB) based on a 2-tissue compartment-3-rate-constant reference region model. Carbon-11 37-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 22273496-6 2012 Exposure to organophosphates significantly reduced AChE activity across season, but was not sufficient enough to claim clinical symptoms whereas exposure to the pyrethroid insecticides and fungicides were sufficient enough to claim acute symptoms of poisoning. Organophosphates 12-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 22832236-1 2012 BACKGROUND: Although donepezil, an acetylcholinesterase inhibitor, has been proved to be effective in ameliorating cognitive impairment in Parkinson"s disease with dementia (PDD), the responsiveness of patients to donepezil therapy varies. Donepezil 21-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 22832236-2 2012 [5-(11)C-methoxy]donepezil, the radiolabeled form of donepezil, is a ligand for positron emission tomography (PET), which can be exploited for the quantitative analysis of donepezil binding to acetylcholinesterase and for cholinergic imaging. (5-methoxy)donepezil 0-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-213 22832236-2 2012 [5-(11)C-methoxy]donepezil, the radiolabeled form of donepezil, is a ligand for positron emission tomography (PET), which can be exploited for the quantitative analysis of donepezil binding to acetylcholinesterase and for cholinergic imaging. Donepezil 17-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-213 22832236-2 2012 [5-(11)C-methoxy]donepezil, the radiolabeled form of donepezil, is a ligand for positron emission tomography (PET), which can be exploited for the quantitative analysis of donepezil binding to acetylcholinesterase and for cholinergic imaging. Donepezil 53-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-213 22832236-8 2012 CONCLUSION: The results suggest that donepezil therapy is more effective in patients with less decrease in acetylcholinesterase, a binding site of donepezil, at least in the specific cognitive domain. Donepezil 37-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 22832236-8 2012 CONCLUSION: The results suggest that donepezil therapy is more effective in patients with less decrease in acetylcholinesterase, a binding site of donepezil, at least in the specific cognitive domain. Donepezil 147-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 22949848-0 2012 2,3-dihydro-1H-cyclopenta[b]quinoline derivatives as acetylcholinesterase inhibitors-synthesis, radiolabeling and biodistribution. 2,3-dihydro-1h-cyclopenta 0-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 22949848-0 2012 2,3-dihydro-1H-cyclopenta[b]quinoline derivatives as acetylcholinesterase inhibitors-synthesis, radiolabeling and biodistribution. quinoline 28-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 22949848-1 2012 In the present study we describe the synthesis and biological assessment of new tacrine analogs in the course of inhibition of acetylcholinesterase. Tacrine 80-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 22387411-0 2012 From anti-Parkinson"s drug rasagiline to novel multitarget iron chelators with acetylcholinesterase and monoamine oxidase inhibitory and neuroprotective properties for Alzheimer"s disease. Iron 59-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 22596267-9 2012 The comparable AChE reductions in pAD and aMCI converters indicate the presence of a widespread impairment of the cholinergic system already in the MCI phase. amci 42-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 22731788-1 2012 We have applied a theoretical methodology, previously developed to evaluate the association and kinetic reactivation constants of oximes, comparing theoretical data obtained for human acetylcholinesterase (HsAChE) with in vitro results from Mus musculus AChE (MmAChE) previously reported in the literature. Oximes 130-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-204 21972196-2 2012 Recent research shows that pyridostigmine bromide protects a significant percentage of acetylcholinesterase in isolated human intercostal muscle. Pyridostigmine Bromide 27-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 22360668-1 2012 Highly toxic organophosphorus inhibitors of acetylcholinesterase referred as nerve agents are considered to be among the most dangerous chemical warfare agents. organophosphorus 13-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 21761139-0 2012 Effects of acetylcholinesterase inhibitor paraoxon denote the possibility of non-quantal acetylcholine release in myocardium of different vertebrates. Paraoxon 42-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 21761139-3 2012 These effects were abolished by muscarinic blocker atropine and therefore are caused by acetylcholine, which accumulates in the myocardium due to acetylcholinesterase inhibition even in the absence of vagal input. Atropine 51-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-166 21761139-3 2012 These effects were abolished by muscarinic blocker atropine and therefore are caused by acetylcholine, which accumulates in the myocardium due to acetylcholinesterase inhibition even in the absence of vagal input. Acetylcholine 88-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-166 22360668-6 2012 The review describes the evaluation of the potency of newly developed oximes (especially the oxime K203) or combinations of oximes to reactivate nerve agent-inhibited acetylcholinesterase and to counteract the acute toxicity of nerve agents in comparison with single commonly used oxime (obidoxime, trimedoxime or HI-6). Oximes 70-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-187 22360668-6 2012 The review describes the evaluation of the potency of newly developed oximes (especially the oxime K203) or combinations of oximes to reactivate nerve agent-inhibited acetylcholinesterase and to counteract the acute toxicity of nerve agents in comparison with single commonly used oxime (obidoxime, trimedoxime or HI-6). oxime k203 93-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-187 22360668-6 2012 The review describes the evaluation of the potency of newly developed oximes (especially the oxime K203) or combinations of oximes to reactivate nerve agent-inhibited acetylcholinesterase and to counteract the acute toxicity of nerve agents in comparison with single commonly used oxime (obidoxime, trimedoxime or HI-6). Oximes 124-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-187 22360668-6 2012 The review describes the evaluation of the potency of newly developed oximes (especially the oxime K203) or combinations of oximes to reactivate nerve agent-inhibited acetylcholinesterase and to counteract the acute toxicity of nerve agents in comparison with single commonly used oxime (obidoxime, trimedoxime or HI-6). Oximes 70-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-187 23233806-2 2012 Galantamine is an acetylcholinesterase inhibitor that may also act via allosteric modulation of nicotinic acetylcholine receptors. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 22808117-0 2012 Energetics of Ortho-7 (oxime drug) translocation through the active-site gorge of tabun conjugated acetylcholinesterase. Oximes 23-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 22808117-1 2012 Oxime drugs translocate through the 20 A active-site gorge of acetylcholinesterase in order to liberate the enzyme from organophosphorus compounds" (such as tabun) conjugation. Oximes 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 22808117-1 2012 Oxime drugs translocate through the 20 A active-site gorge of acetylcholinesterase in order to liberate the enzyme from organophosphorus compounds" (such as tabun) conjugation. organophosphorus 120-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 22808117-1 2012 Oxime drugs translocate through the 20 A active-site gorge of acetylcholinesterase in order to liberate the enzyme from organophosphorus compounds" (such as tabun) conjugation. tabun 157-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 21799476-4 2011 The main toxic mechanism of OPCs is the inhibition of the enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), resulting in accumulation of acetylcholine (ACh) at the synapse with cholinergic crisis and possible death. Acetylcholine 66-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 21937214-0 2011 Site-specific immobilization of a (His)6-tagged acetylcholinesterase on nickel nanoparticles for highly sensitive toxicity biosensors. Nickel 72-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 21937214-1 2011 This paper reports site-specific affinity immobilization of (His)6-tagged acetylcholinesterase (AChE) onto Ni/NiO nanoparticles for the development of an electrochemical screen-printed biosensor for the detection of organophosphate pesticides. Organophosphates 216-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 21937214-1 2011 This paper reports site-specific affinity immobilization of (His)6-tagged acetylcholinesterase (AChE) onto Ni/NiO nanoparticles for the development of an electrochemical screen-printed biosensor for the detection of organophosphate pesticides. Organophosphates 216-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 21600321-0 2011 An acetylcholinesterase biosensor for determination of low concentrations of Paraoxon and Dichlorvos. Paraoxon 77-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 3-23 21600321-1 2011 The characterization of an economic and ease-to-use carbon paste acetylcholinesterase (AChE) based biosensor to determine the concentration of pesticides Paraoxon and Dichlorvos is discussed. Paraoxon 154-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 21600321-1 2011 The characterization of an economic and ease-to-use carbon paste acetylcholinesterase (AChE) based biosensor to determine the concentration of pesticides Paraoxon and Dichlorvos is discussed. Paraoxon 154-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 21600321-2 2011 AChE hydrolyses acetylthiocholine (ATCh) in thiocoline (TC) and acetic acid (AA). Acetylthiocholine 16-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 21600321-2 2011 AChE hydrolyses acetylthiocholine (ATCh) in thiocoline (TC) and acetic acid (AA). Acetylthiocholine 35-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 21600321-2 2011 AChE hydrolyses acetylthiocholine (ATCh) in thiocoline (TC) and acetic acid (AA). thiocoline 44-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 21600321-2 2011 AChE hydrolyses acetylthiocholine (ATCh) in thiocoline (TC) and acetic acid (AA). Technetium 36-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 21600321-2 2011 AChE hydrolyses acetylthiocholine (ATCh) in thiocoline (TC) and acetic acid (AA). Acetic Acid 64-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 21600321-3 2011 When AChE is immobilized into a paste carbon working electrode kept at +410 mV vs. Ag/AgCl electrode, the enzyme reaction rate using acetylthiocholine chloride (ATCl) as substrate is monitored as a current intensity. Carbon 38-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 21600321-3 2011 When AChE is immobilized into a paste carbon working electrode kept at +410 mV vs. Ag/AgCl electrode, the enzyme reaction rate using acetylthiocholine chloride (ATCl) as substrate is monitored as a current intensity. silver chloride 86-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 21600321-3 2011 When AChE is immobilized into a paste carbon working electrode kept at +410 mV vs. Ag/AgCl electrode, the enzyme reaction rate using acetylthiocholine chloride (ATCl) as substrate is monitored as a current intensity. Acetylthiocholine chloride 133-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 21600321-3 2011 When AChE is immobilized into a paste carbon working electrode kept at +410 mV vs. Ag/AgCl electrode, the enzyme reaction rate using acetylthiocholine chloride (ATCl) as substrate is monitored as a current intensity. atcl 161-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 21600321-4 2011 Because Paraoxon and Dichlorvos inhibit the AChE reaction, the decrease of the current intensity, at fixed ATCl concentration, is a measure of their concentration. Paraoxon 8-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 21600321-4 2011 Because Paraoxon and Dichlorvos inhibit the AChE reaction, the decrease of the current intensity, at fixed ATCl concentration, is a measure of their concentration. Dichlorvos 21-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 21600321-4 2011 Because Paraoxon and Dichlorvos inhibit the AChE reaction, the decrease of the current intensity, at fixed ATCl concentration, is a measure of their concentration. atcl 107-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 22152059-1 2011 BACKGROUND: Berberine (BER), the major alkaloidal component of Rhizoma coptidis, has multiple pharmacological effects including inhibition of acetylcholinesterase, reduction of cholesterol and glucose levels, anti-inflammatory, neuroprotective and neurotrophic effects. Berberine 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 22152059-1 2011 BACKGROUND: Berberine (BER), the major alkaloidal component of Rhizoma coptidis, has multiple pharmacological effects including inhibition of acetylcholinesterase, reduction of cholesterol and glucose levels, anti-inflammatory, neuroprotective and neurotrophic effects. Berberine 23-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 21872646-4 2011 In AD brain, AChE is diminished while BuChE is not, suggesting BuChE inhibition may be important in raising acetylcholine levels. Acetylcholine 108-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 22465999-1 2012 Alzheimer"s disease (AD) is a neurodegenerative disorder often treated with donepezil, an acetylcholinesterase inhibitor. Donepezil 76-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 22075233-2 2011 The lead structures (5-benzylidenerhodanine 4a and 5-benzylidene-2,4-thiazolidinedione 4b) were identified in an in-house screening and these inhibited CEase with some selectivity over another serine hydrolase, acetylcholinesterase (AChE) (4a, CEase IC(50)=1.76 muM vs AChE IC(50)=5.14 muM and 4b, CEase IC(50)=5.89 muM vs AChE IC(50) >100 muM). 5-benzylidenerhodanine 4a 21-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-231 22075233-2 2011 The lead structures (5-benzylidenerhodanine 4a and 5-benzylidene-2,4-thiazolidinedione 4b) were identified in an in-house screening and these inhibited CEase with some selectivity over another serine hydrolase, acetylcholinesterase (AChE) (4a, CEase IC(50)=1.76 muM vs AChE IC(50)=5.14 muM and 4b, CEase IC(50)=5.89 muM vs AChE IC(50) >100 muM). 5-benzylidenerhodanine 4a 21-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-237 22075233-2 2011 The lead structures (5-benzylidenerhodanine 4a and 5-benzylidene-2,4-thiazolidinedione 4b) were identified in an in-house screening and these inhibited CEase with some selectivity over another serine hydrolase, acetylcholinesterase (AChE) (4a, CEase IC(50)=1.76 muM vs AChE IC(50)=5.14 muM and 4b, CEase IC(50)=5.89 muM vs AChE IC(50) >100 muM). 5-benzylidenerhodanine 4a 21-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 269-273 22075233-2 2011 The lead structures (5-benzylidenerhodanine 4a and 5-benzylidene-2,4-thiazolidinedione 4b) were identified in an in-house screening and these inhibited CEase with some selectivity over another serine hydrolase, acetylcholinesterase (AChE) (4a, CEase IC(50)=1.76 muM vs AChE IC(50)=5.14 muM and 4b, CEase IC(50)=5.89 muM vs AChE IC(50) >100 muM). 5-benzylidenerhodanine 4a 21-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 269-273 22075233-2 2011 The lead structures (5-benzylidenerhodanine 4a and 5-benzylidene-2,4-thiazolidinedione 4b) were identified in an in-house screening and these inhibited CEase with some selectivity over another serine hydrolase, acetylcholinesterase (AChE) (4a, CEase IC(50)=1.76 muM vs AChE IC(50)=5.14 muM and 4b, CEase IC(50)=5.89 muM vs AChE IC(50) >100 muM). 5-benzylidene thiazolidine-2,4-dione 51-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-231 22075233-2 2011 The lead structures (5-benzylidenerhodanine 4a and 5-benzylidene-2,4-thiazolidinedione 4b) were identified in an in-house screening and these inhibited CEase with some selectivity over another serine hydrolase, acetylcholinesterase (AChE) (4a, CEase IC(50)=1.76 muM vs AChE IC(50)=5.14 muM and 4b, CEase IC(50)=5.89 muM vs AChE IC(50) >100 muM). 5-benzylidene thiazolidine-2,4-dione 51-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-237 22099654-2 2011 The assay principle is based on catalytic hydrolysis of acetylthiocholine into thiocholine by acetylcholinesterase, which induces the aggregation of Au nanoparticles and the color change from claret-red to purple or even grey. Acetylthiocholine 56-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 22099654-2 2011 The assay principle is based on catalytic hydrolysis of acetylthiocholine into thiocholine by acetylcholinesterase, which induces the aggregation of Au nanoparticles and the color change from claret-red to purple or even grey. Thiocholine 62-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 22099654-2 2011 The assay principle is based on catalytic hydrolysis of acetylthiocholine into thiocholine by acetylcholinesterase, which induces the aggregation of Au nanoparticles and the color change from claret-red to purple or even grey. Gold 149-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 22099654-4 2011 The irreversible inhibition of organophosphorus pesticides on acetylcholinesterase prevents aggregation of Au nanoparticles. organophosphorus 31-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 21994917-0 2011 An electrochemical platform for acetylcholinesterase activity assay and inhibitors screening based on Michael addition reaction between thiocholine and catechol-terminated SAMs. Thiocholine 136-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 21994917-0 2011 An electrochemical platform for acetylcholinesterase activity assay and inhibitors screening based on Michael addition reaction between thiocholine and catechol-terminated SAMs. catechol 152-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 21994917-1 2011 An electrochemical platform for acetylcholinesterase (AChE) activity assay and its inhibitors screening is developed based on the Michael addition reaction of thiocholine, the hydrolysis product of acetylthiocholine (AsCh) in the presence of AChE, with the electrogenerated o-quinone of catechol-terminated SAMs on a gold electrode. Thiocholine 159-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 21994917-1 2011 An electrochemical platform for acetylcholinesterase (AChE) activity assay and its inhibitors screening is developed based on the Michael addition reaction of thiocholine, the hydrolysis product of acetylthiocholine (AsCh) in the presence of AChE, with the electrogenerated o-quinone of catechol-terminated SAMs on a gold electrode. Thiocholine 159-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 21994917-1 2011 An electrochemical platform for acetylcholinesterase (AChE) activity assay and its inhibitors screening is developed based on the Michael addition reaction of thiocholine, the hydrolysis product of acetylthiocholine (AsCh) in the presence of AChE, with the electrogenerated o-quinone of catechol-terminated SAMs on a gold electrode. Thiocholine 159-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 242-246 21994917-1 2011 An electrochemical platform for acetylcholinesterase (AChE) activity assay and its inhibitors screening is developed based on the Michael addition reaction of thiocholine, the hydrolysis product of acetylthiocholine (AsCh) in the presence of AChE, with the electrogenerated o-quinone of catechol-terminated SAMs on a gold electrode. Acetylthiocholine 198-215 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 21994917-1 2011 An electrochemical platform for acetylcholinesterase (AChE) activity assay and its inhibitors screening is developed based on the Michael addition reaction of thiocholine, the hydrolysis product of acetylthiocholine (AsCh) in the presence of AChE, with the electrogenerated o-quinone of catechol-terminated SAMs on a gold electrode. Acetylthiocholine 198-215 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 21994917-1 2011 An electrochemical platform for acetylcholinesterase (AChE) activity assay and its inhibitors screening is developed based on the Michael addition reaction of thiocholine, the hydrolysis product of acetylthiocholine (AsCh) in the presence of AChE, with the electrogenerated o-quinone of catechol-terminated SAMs on a gold electrode. Acetylthiocholine 198-215 acetylcholinesterase (Cartwright blood group) Homo sapiens 242-246 21994917-1 2011 An electrochemical platform for acetylcholinesterase (AChE) activity assay and its inhibitors screening is developed based on the Michael addition reaction of thiocholine, the hydrolysis product of acetylthiocholine (AsCh) in the presence of AChE, with the electrogenerated o-quinone of catechol-terminated SAMs on a gold electrode. asch 217-221 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 21994917-1 2011 An electrochemical platform for acetylcholinesterase (AChE) activity assay and its inhibitors screening is developed based on the Michael addition reaction of thiocholine, the hydrolysis product of acetylthiocholine (AsCh) in the presence of AChE, with the electrogenerated o-quinone of catechol-terminated SAMs on a gold electrode. asch 217-221 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 21994917-1 2011 An electrochemical platform for acetylcholinesterase (AChE) activity assay and its inhibitors screening is developed based on the Michael addition reaction of thiocholine, the hydrolysis product of acetylthiocholine (AsCh) in the presence of AChE, with the electrogenerated o-quinone of catechol-terminated SAMs on a gold electrode. asch 217-221 acetylcholinesterase (Cartwright blood group) Homo sapiens 242-246 21994917-1 2011 An electrochemical platform for acetylcholinesterase (AChE) activity assay and its inhibitors screening is developed based on the Michael addition reaction of thiocholine, the hydrolysis product of acetylthiocholine (AsCh) in the presence of AChE, with the electrogenerated o-quinone of catechol-terminated SAMs on a gold electrode. 2-benzoquinone 274-283 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 21994917-1 2011 An electrochemical platform for acetylcholinesterase (AChE) activity assay and its inhibitors screening is developed based on the Michael addition reaction of thiocholine, the hydrolysis product of acetylthiocholine (AsCh) in the presence of AChE, with the electrogenerated o-quinone of catechol-terminated SAMs on a gold electrode. 2-benzoquinone 274-283 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 21994917-1 2011 An electrochemical platform for acetylcholinesterase (AChE) activity assay and its inhibitors screening is developed based on the Michael addition reaction of thiocholine, the hydrolysis product of acetylthiocholine (AsCh) in the presence of AChE, with the electrogenerated o-quinone of catechol-terminated SAMs on a gold electrode. catechol 287-295 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 21994917-1 2011 An electrochemical platform for acetylcholinesterase (AChE) activity assay and its inhibitors screening is developed based on the Michael addition reaction of thiocholine, the hydrolysis product of acetylthiocholine (AsCh) in the presence of AChE, with the electrogenerated o-quinone of catechol-terminated SAMs on a gold electrode. catechol 287-295 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 21994917-3 2011 The enzyme kinetics and the inhibition effects of three types of AChE inhibitors, which are tacrine, carbofuran and parathion-methyl, have been investigated using an amperometric method. Tacrine 92-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 21994917-3 2011 The enzyme kinetics and the inhibition effects of three types of AChE inhibitors, which are tacrine, carbofuran and parathion-methyl, have been investigated using an amperometric method. Carbofuran 101-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 21994917-3 2011 The enzyme kinetics and the inhibition effects of three types of AChE inhibitors, which are tacrine, carbofuran and parathion-methyl, have been investigated using an amperometric method. Methyl Parathion 116-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 22098995-2 2011 The Test-mate ChE 400 is a portable field kit designed for detecting occupational organophosphorus exposure that measures RBC AChE and plasma cholinesterase (PChE) within 4 minutes. organophosphorus 82-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 22019465-0 2011 Searching for the Multi-Target-Directed Ligands against Alzheimer"s disease: discovery of quinoxaline-based hybrid compounds with AChE, H3R and BACE 1 inhibitory activities. Quinoxalines 90-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 22019465-1 2011 A novel series of quinoxaline derivatives, as Multi-Target-Directed Ligands (MTDLs) for AD treatment, were designed by lending the core structural elements required for H(3)R antagonists and hybridizing BACE 1 inhibitor 1 with AChE inhibitor BYYT-25. Quinoxalines 18-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 227-231 22019465-2 2011 A virtual database consisting of quinoxaline derivatives was first screened on a pharmacophore model of BACE 1 inhibitors, and then filtered by a molecular docking model of AChE. Quinoxalines 33-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-177 22229321-0 2011 Human platelet acetylcholinesterase inhibition by cyclophosphamide: a combined experimental and computational approach. Cyclophosphamide 50-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 22229321-2 2011 In the present study, a comparative multiple 4 dimensional (4D)-approach was applied to analyze human platelet AChE-inhibition by cyclophosphamide (CP). Cyclophosphamide 130-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 22229321-3 2011 AChE activity was assessed by measuring the hydrolysis of acetylthiocholine iodide (ASChI). acetylthiocholine iodide 58-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 22229321-3 2011 AChE activity was assessed by measuring the hydrolysis of acetylthiocholine iodide (ASChI). aschi 84-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 22229321-9 2011 CP displayed variable docking poses with the peripheral anionic site (PAS) of human AChE. Aminosalicylic Acid 70-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 22161694-1 2011 OBJECTIVES: To identify tasks that were sensitive to a temporary decline in cognitive performance after sleep deprivation and to investigate the ability of the acetylcholinesterase inhibitor donepezil to reverse any sleep deprivation-induced impairment. Donepezil 191-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-180 21952774-2 2011 First, model enzyme acetylcholinesterase (AChE) was immobilized onto the 3-glycidoxypropyltrimethoxysilane (GLYMO)-modified magnetic carbonaceous (MC) microspheres, displaying a high enzyme activity and stability, and also facilitating the separation of enzyme from substrate and product. 3-glycidoxypropyltrimethoxysilane 73-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 21952774-2 2011 First, model enzyme acetylcholinesterase (AChE) was immobilized onto the 3-glycidoxypropyltrimethoxysilane (GLYMO)-modified magnetic carbonaceous (MC) microspheres, displaying a high enzyme activity and stability, and also facilitating the separation of enzyme from substrate and product. 3-glycidoxypropyltrimethoxysilane 73-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 21952774-2 2011 First, model enzyme acetylcholinesterase (AChE) was immobilized onto the 3-glycidoxypropyltrimethoxysilane (GLYMO)-modified magnetic carbonaceous (MC) microspheres, displaying a high enzyme activity and stability, and also facilitating the separation of enzyme from substrate and product. 3-glycidoxypropyltrimethoxysilane 108-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 21952774-2 2011 First, model enzyme acetylcholinesterase (AChE) was immobilized onto the 3-glycidoxypropyltrimethoxysilane (GLYMO)-modified magnetic carbonaceous (MC) microspheres, displaying a high enzyme activity and stability, and also facilitating the separation of enzyme from substrate and product. 3-glycidoxypropyltrimethoxysilane 108-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 21952774-3 2011 The efficiency of immobilized AChE was monitored by biochemical assay, which was carried out by mixing enzyme-immobilized MC microspheres with model substrate acetylcholine (ACh), and subsequent quantitative determination of substrate ACh and product choline using graphene oxide-based MALDI-TOF-MS with no background inference. Methylcholanthrene 122-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 21952774-3 2011 The efficiency of immobilized AChE was monitored by biochemical assay, which was carried out by mixing enzyme-immobilized MC microspheres with model substrate acetylcholine (ACh), and subsequent quantitative determination of substrate ACh and product choline using graphene oxide-based MALDI-TOF-MS with no background inference. Acetylcholine 159-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 21952774-3 2011 The efficiency of immobilized AChE was monitored by biochemical assay, which was carried out by mixing enzyme-immobilized MC microspheres with model substrate acetylcholine (ACh), and subsequent quantitative determination of substrate ACh and product choline using graphene oxide-based MALDI-TOF-MS with no background inference. Acetylcholine 174-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 21952774-3 2011 The efficiency of immobilized AChE was monitored by biochemical assay, which was carried out by mixing enzyme-immobilized MC microspheres with model substrate acetylcholine (ACh), and subsequent quantitative determination of substrate ACh and product choline using graphene oxide-based MALDI-TOF-MS with no background inference. Choline 165-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 21952774-3 2011 The efficiency of immobilized AChE was monitored by biochemical assay, which was carried out by mixing enzyme-immobilized MC microspheres with model substrate acetylcholine (ACh), and subsequent quantitative determination of substrate ACh and product choline using graphene oxide-based MALDI-TOF-MS with no background inference. graphene oxide 265-279 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 21799476-4 2011 The main toxic mechanism of OPCs is the inhibition of the enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), resulting in accumulation of acetylcholine (ACh) at the synapse with cholinergic crisis and possible death. Acetylcholine 88-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 21799476-6 2011 Standard treatment involves the administration of intravenous atropine and an oxime to counteract acetylcholinesterase inhibition at the synapse, but the usefulness of oximes is still debated. Oximes 78-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-118 21723318-11 2011 This indicates that peripheral and central AChE activities are not necessarily correlated after the treatment of OP compounds and/or oximes, which should be taken into account in the diagnosis and management of OP-exposed humans. Oximes 133-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 21983245-0 2011 Potential of two new oximes in reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by organophosphate compounds: an in vitro study. Oximes 21-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 21983245-3 2011 In this study, we compared the in vitro reactivation potency of two new oximes (oxime 1: butane-2,3-dionethiosemicarbazone; oxime 2: 3-(phenylhydrazono) butan-2-one) against the inhibition on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities induced by chlorpyrifos, diazinon and malathion. Oximes 72-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-212 21983245-3 2011 In this study, we compared the in vitro reactivation potency of two new oximes (oxime 1: butane-2,3-dionethiosemicarbazone; oxime 2: 3-(phenylhydrazono) butan-2-one) against the inhibition on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities induced by chlorpyrifos, diazinon and malathion. Oximes 72-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-218 21983245-7 2011 Results demonstrated that obidoxime was more effective in reactivate the AChE inhibition induced by OP compounds. Obidoxime Chloride 26-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 21983245-8 2011 However, both newly developed oximes achieved similar reactivations rates that pralidoxime for chlorpyrifos and diazinon-inhibited AChE. Oximes 30-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 21983245-8 2011 However, both newly developed oximes achieved similar reactivations rates that pralidoxime for chlorpyrifos and diazinon-inhibited AChE. pralidoxime 79-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 21983245-8 2011 However, both newly developed oximes achieved similar reactivations rates that pralidoxime for chlorpyrifos and diazinon-inhibited AChE. Diazinon 112-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 21983245-10 2011 We conclude that both newly developed oximes seem to be promising reactivators of OP-inhibited AChE. Oximes 38-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 21930118-0 2011 Reactivation of organophosphate-inhibited human acetylcholinesterase by isonitrosoacetone (MINA): a kinetic analysis. Organophosphates 16-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 21930118-0 2011 Reactivation of organophosphate-inhibited human acetylcholinesterase by isonitrosoacetone (MINA): a kinetic analysis. isonitrosoacetone 72-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 21930118-0 2011 Reactivation of organophosphate-inhibited human acetylcholinesterase by isonitrosoacetone (MINA): a kinetic analysis. isonitrosoacetone 91-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 21930118-1 2011 Treatment of poisoning by highly toxic organophosphorus compounds (OP) with atropine and an acetylcholinesterase (AChE) reactivator (oxime) is of limited effectiveness in case of different nerve agents and pesticides. Organophosphorus Compounds 39-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 21930118-1 2011 Treatment of poisoning by highly toxic organophosphorus compounds (OP) with atropine and an acetylcholinesterase (AChE) reactivator (oxime) is of limited effectiveness in case of different nerve agents and pesticides. Oximes 133-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 21930118-1 2011 Treatment of poisoning by highly toxic organophosphorus compounds (OP) with atropine and an acetylcholinesterase (AChE) reactivator (oxime) is of limited effectiveness in case of different nerve agents and pesticides. Oximes 133-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 21930118-4 2011 Now, an in vitro study was performed to determine the reactivation kinetics of MINA with tabun-, sarin-, cyclosarin-, VX- and paraoxon-inhibited human AChE. cyclohexyl methylphosphonofluoridate 105-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 21930118-4 2011 Now, an in vitro study was performed to determine the reactivation kinetics of MINA with tabun-, sarin-, cyclosarin-, VX- and paraoxon-inhibited human AChE. Paraoxon 126-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 22064271-0 2011 Synthesis, characterization, acetylcholinesterase inhibition, molecular modeling and antioxidant activities of some novel Schiff bases derived from 1-(2-ketoiminoethyl)piperazines. Schiff Bases 122-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 22064271-0 2011 Synthesis, characterization, acetylcholinesterase inhibition, molecular modeling and antioxidant activities of some novel Schiff bases derived from 1-(2-ketoiminoethyl)piperazines. 1-(2-ketoiminoethyl)piperazines 148-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 22064271-5 2011 This high activity of DHP was checked by molecular modeling which showed that DHP could not be considered as a bivalent ligand due to its incapability to occupy the esteratic site (ES) region of the 3D crystal structure of hAChE. Einsteinium 181-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 223-228 21999734-0 2011 Interaction of human brain acetylcholinesterase with cyclophosphamide: a molecular modeling and docking study. Cyclophosphamide 53-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 21999734-1 2011 This study describes the interaction between human acetylcholinesterase (AChE), a key regulator of central and peripheral cholinergic function, and the widely used nitrogen mustard alkylating agent, cyclophosphamide (CP). Nitrogen 164-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 21999734-1 2011 This study describes the interaction between human acetylcholinesterase (AChE), a key regulator of central and peripheral cholinergic function, and the widely used nitrogen mustard alkylating agent, cyclophosphamide (CP). Nitrogen 164-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 21999734-1 2011 This study describes the interaction between human acetylcholinesterase (AChE), a key regulator of central and peripheral cholinergic function, and the widely used nitrogen mustard alkylating agent, cyclophosphamide (CP). Cyclophosphamide 199-215 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 21999734-1 2011 This study describes the interaction between human acetylcholinesterase (AChE), a key regulator of central and peripheral cholinergic function, and the widely used nitrogen mustard alkylating agent, cyclophosphamide (CP). Cyclophosphamide 199-215 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 21999734-8 2011 Apart from other interaction-types, six carbon atoms of CP (C1, C2, C3, C4, C6 and C7) were determined to be involved in hydrophobic interactions with amino acid residues Y121, W233, L323, F331, F335 and Y338 of the "acyl pocket" within AChE. Carbon 40-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 237-241 22085162-1 2011 We used a hypothesis-based weight-of-evidence (HBWoE) approach to analyze the evidence regarding the hypothesis that chlorpyrifos can cause neurodevelopmental effects below the threshold for inhibition of acetylcholinesterase activity in the nervous system, which is an established mode of action for chlorpyrifos neurotoxicity. Chlorpyrifos 117-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 205-225 22039876-1 2011 The occurrence of orthosteric and allosteric binding sites is a characteristic common feature of several acetylcholine- binding proteins, like acetylcholinesterase or the nicotinic and muscarinic acetylcholine receptors. Acetylcholine 105-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 22039876-5 2011 Especially, the development of a hydrazide linker for tacrine-derived heterodimers is highlighted by applications in the inhibition of cholinesterases, the bivalent binding to nicotinic and muscarinic acetylcholine receptors, as well as the histochemical imaging of acetylcholinesterase and amyloid-beta. Isoniazid 33-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 266-286 21924801-2 2011 Its structure was previously combined with that of the acetylcholinesterase inhibitor tacrine to give lipocrine (1), a lead compound multitargeted against Alzheimer"s disease (AD). lipocrine 102-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 21871694-0 2011 Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation inhibitors. oxoisoaporphine 11-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 21668653-1 2011 Protection of the enzyme acetylcholinesterase (AChE) from the toxic effects of organophosphate insecticides and chemical warfare agents (OPs) may be provided by inhibitors that bind at the peripheral binding site (P-site) near the mouth of the active-site gorge. Organophosphates 79-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 21668653-1 2011 Protection of the enzyme acetylcholinesterase (AChE) from the toxic effects of organophosphate insecticides and chemical warfare agents (OPs) may be provided by inhibitors that bind at the peripheral binding site (P-site) near the mouth of the active-site gorge. Organophosphates 79-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 21815707-4 2011 This review focuses on treatment of MG, mainly on the use of the AChE inhibitor pyridostigmine. Pyridostigmine Bromide 80-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 21815707-5 2011 Despite a lack of data from well controlled clinical trials to support their use, AChE inhibitors, of which pyridostigmine is the most commonly used, are recommended as first-line therapy for MG. Pyridostigmine has been used as a treatment for MG for over 50 years and is generally considered safe. Pyridostigmine Bromide 108-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 21815707-5 2011 Despite a lack of data from well controlled clinical trials to support their use, AChE inhibitors, of which pyridostigmine is the most commonly used, are recommended as first-line therapy for MG. Pyridostigmine has been used as a treatment for MG for over 50 years and is generally considered safe. Pyridostigmine Bromide 196-210 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 21815707-7 2011 Novel AChE inhibitors with oral antisense oligonucleotides have been developed and preliminary results appear to be promising. Oligonucleotides 42-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 21815707-8 2011 In general, however, AChE inhibitors provide only partial benefit and most patients eventually switch to long-term immunosuppressive therapies, most frequently corticosteroids and/or azathioprine. Azathioprine 183-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 21737173-1 2011 The aim of the present study was to investigate the effects of Syzygium cumini leaf extract (ASc), on Adenosine deaminase (ADA) and Acetylcholinesterase (AChE) activities, and also on oxidative stress parameters in erythrocytes hemolysates (RBCs) and erythrocytes membranes (ghosts) from type 2 diabetics patients (Type 2 DM) under in vitro conditions. cumini leaf extract 72-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-158 22019228-1 2011 A series of 9-N-substituted berberine derivatives were synthesized and biologically evaluated as antioxidant and inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase and amyloid-beta aggregation. 9-n-substituted berberine 12-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 22019228-3 2011 Among them, compound 8d, (o-methylphenethyl)amino linked at the 9-position of berberine, was found to be a good antioxidant (with 4.05 muM of Trolox equivalents), potent inhibitor of AChE (an IC(50) value of 0.027 muM), and high active inhibitor of amyloid-beta aggregation (an IC(50) value of 2.73 muM). Berberine 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-187 21381051-5 2011 ToxCast assay endpoints related to acetylcholinesterase (AChE) inhibition had low sensitivity for detecting organophosphate pesticides but good sensitivity for detecting N-methyl carbamates. Organophosphates 109-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 21381051-5 2011 ToxCast assay endpoints related to acetylcholinesterase (AChE) inhibition had low sensitivity for detecting organophosphate pesticides but good sensitivity for detecting N-methyl carbamates. Organophosphates 109-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 21381051-5 2011 ToxCast assay endpoints related to acetylcholinesterase (AChE) inhibition had low sensitivity for detecting organophosphate pesticides but good sensitivity for detecting N-methyl carbamates. N-methylcarbamate 171-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 21381051-5 2011 ToxCast assay endpoints related to acetylcholinesterase (AChE) inhibition had low sensitivity for detecting organophosphate pesticides but good sensitivity for detecting N-methyl carbamates. N-methylcarbamate 171-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 21865354-7 2011 MAIN OUTCOME MEASURE: We measured cholinergic activity (acetylcholinesterase) in the hippocampus and posterior cingulate brain regions as measured by N-[(11)C]methylpiperidin-4-yl propionate and positron emission tomography as a marker of cholinergic function. n-[(11)c]methylpiperidin-4-yl propionate 150-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 22003926-3 2011 Studies in agricultural workers from several regions of the country reported moderate to severe cholinergic symptoms, including decreased acetylcholinesterase (AChE) activity (the main acute OP toxic effect that causes an over accumulation of the neurotransmitter acetylcholine), revealing the potential risk of intoxication of Mexican farmers. Acetylcholine 138-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 21916483-0 2011 Novel water-soluble red-emitting poly(p-phenylenevinylene) derivative: synthesis, characterization, and fluorescent acetylcholinesterase assays. Water 6-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 21916483-0 2011 Novel water-soluble red-emitting poly(p-phenylenevinylene) derivative: synthesis, characterization, and fluorescent acetylcholinesterase assays. poly(4-phenylenevinylene) 33-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 21916483-6 2011 Making use of the charge reversal of dinitrobenzene-modified substrate, a "turn-on" method is developed for AChE activity assay with the new polymer as a fluorophore. Dinitrobenzenes 37-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 21916483-6 2011 Making use of the charge reversal of dinitrobenzene-modified substrate, a "turn-on" method is developed for AChE activity assay with the new polymer as a fluorophore. Polymers 141-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 21889639-2 2011 Acetylcholinesterase (AChE) mediated the hydrolysis of acetylthiocholine to produce thiocholine, which interacted with the silver nanoparticles to give a specific SERS spectrum. Acetylthiocholine 55-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21889639-2 2011 Acetylcholinesterase (AChE) mediated the hydrolysis of acetylthiocholine to produce thiocholine, which interacted with the silver nanoparticles to give a specific SERS spectrum. Acetylthiocholine 55-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 21889639-2 2011 Acetylcholinesterase (AChE) mediated the hydrolysis of acetylthiocholine to produce thiocholine, which interacted with the silver nanoparticles to give a specific SERS spectrum. Thiocholine 61-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21889639-2 2011 Acetylcholinesterase (AChE) mediated the hydrolysis of acetylthiocholine to produce thiocholine, which interacted with the silver nanoparticles to give a specific SERS spectrum. Thiocholine 61-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 21889639-2 2011 Acetylcholinesterase (AChE) mediated the hydrolysis of acetylthiocholine to produce thiocholine, which interacted with the silver nanoparticles to give a specific SERS spectrum. sers 163-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21889639-2 2011 Acetylcholinesterase (AChE) mediated the hydrolysis of acetylthiocholine to produce thiocholine, which interacted with the silver nanoparticles to give a specific SERS spectrum. sers 163-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 21889639-4 2011 The method was demonstrated for the detection of paraoxon as reference AChE inhibitor. Paraoxon 49-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 21842444-6 2011 The immobilization efficiency of the chitosan-coated microplate was demonstrated to be far superior to that of a conventional microplate when tested using acetylcholinesterase (AChE) and beta-glucosidase as model biomolecules, and the chitosan-coated microplate may thus have potential applications in biosensing and bioreactor systems. Chitosan 37-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-175 21842444-6 2011 The immobilization efficiency of the chitosan-coated microplate was demonstrated to be far superior to that of a conventional microplate when tested using acetylcholinesterase (AChE) and beta-glucosidase as model biomolecules, and the chitosan-coated microplate may thus have potential applications in biosensing and bioreactor systems. Chitosan 37-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-181 22006717-6 2011 Acetylcholinesterase (AChE) inhibition and cytotoxicity tests against five human cancer cell lines showed that only rhodanthenone D (4) and mangiferin (12) exhibited 18.4 and 13.4% of AChE inhibitory effects at a concentration of 10(-4) M, respectively, while compounds 1-5 and the known xanthones lancerin (11), mangiferin (12), and neomangiferin (13) displayed no cytotoxicity at a concentration of 40 muM. rhodanthenone d 116-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-188 21871694-0 2011 Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation inhibitors. oxoisoaporphine 11-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 21871694-0 2011 Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation inhibitors. Tacrine 27-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 21871694-4 2011 Moreover, five out of the 12 hybrids of this series, particularly those bearing a tetrahydroacridine moiety, exhibit a significant in vitro inhibitory activity toward the AChE-induced and self-induced Abeta aggregation, which makes them promising anti-Alzheimer drug candidates. 1,2,3,4-Tetrahydroacridine 82-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 21414391-0 2011 In vitro kinetic interactions of pyridostigmine, physostigmine and soman with erythrocyte and muscle acetylcholinesterase from different species. Pyridostigmine Bromide 33-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 21899553-2 2011 In this study selected components of essential oils, which carry a variety of important functional groups, were tested for their in-vitro anti-acetylcholinesterase activity. Oils, Volatile 37-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 21899553-4 2011 KEY FINDINGS: 1,8-cineole, carvacrol, myrtenal and verbenone apparently inhibited AChE; the highest inhibitory activity was observed for myrtenal (IC50 = 0.17 mm). Eucalyptol 14-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 21899553-4 2011 KEY FINDINGS: 1,8-cineole, carvacrol, myrtenal and verbenone apparently inhibited AChE; the highest inhibitory activity was observed for myrtenal (IC50 = 0.17 mm). carvacrol 27-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 21899553-4 2011 KEY FINDINGS: 1,8-cineole, carvacrol, myrtenal and verbenone apparently inhibited AChE; the highest inhibitory activity was observed for myrtenal (IC50 = 0.17 mm). myrtenal 38-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 21899553-4 2011 KEY FINDINGS: 1,8-cineole, carvacrol, myrtenal and verbenone apparently inhibited AChE; the highest inhibitory activity was observed for myrtenal (IC50 = 0.17 mm). verbenone 51-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 21899553-6 2011 CONCLUSIONS: Our investigations provided evidence for the efficacy of monoterpenes as inhibitors of AChE. Monoterpenes 70-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 21569834-1 2011 Many neurotoxic organophosphates (OPs) inhibit acetylcholinesterase (AChE) and as a result can cause a life threatening cholinergic crisis. Organophosphates 16-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 21569834-1 2011 Many neurotoxic organophosphates (OPs) inhibit acetylcholinesterase (AChE) and as a result can cause a life threatening cholinergic crisis. Organophosphates 16-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 21569834-1 2011 Many neurotoxic organophosphates (OPs) inhibit acetylcholinesterase (AChE) and as a result can cause a life threatening cholinergic crisis. Organophosphates 34-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 21569834-1 2011 Many neurotoxic organophosphates (OPs) inhibit acetylcholinesterase (AChE) and as a result can cause a life threatening cholinergic crisis. Organophosphates 34-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 21569834-8 2011 Pralidoxime partially regenerated AChE activity and protected against POX inhibition of PSs. pralidoxime 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 21414391-0 2011 In vitro kinetic interactions of pyridostigmine, physostigmine and soman with erythrocyte and muscle acetylcholinesterase from different species. Physostigmine 49-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 21414391-6 2011 It was possible to show that with erythrocyte and muscle AChE a similar level of protection by carbamates and reactivation after discontinuation of the carbamates and soman could be observed. Carbamates 95-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 21414391-6 2011 It was possible to show that with erythrocyte and muscle AChE a similar level of protection by carbamates and reactivation after discontinuation of the carbamates and soman could be observed. Carbamates 152-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 21414391-7 2011 Thus, these data indicate that carbamate pre-treatment is expected to protect a critical level of muscle AChE and confirm the presumption that erythrocyte AChE may serve as a surrogate for synaptic AChE. Carbamates 31-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 21504785-0 2011 Peripheral site ligand conjugation to a non-quaternary oxime enhances reactivation of nerve agent-inhibited human acetylcholinesterase. Oximes 55-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 21504785-1 2011 Commonly employed pyridinium-oxime (charged) reactivators of nerve agent inhibited acetylcholinesterase (AChE) do not readily pass the blood brain barrier (BBB) because of the presence of charge(s). pyridinium-oxime 18-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 21504785-1 2011 Commonly employed pyridinium-oxime (charged) reactivators of nerve agent inhibited acetylcholinesterase (AChE) do not readily pass the blood brain barrier (BBB) because of the presence of charge(s). pyridinium-oxime 18-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 21504785-2 2011 Conversely, non-ionic oxime reactivators often suffer from a lack of reactivating potency due to a low affinity for the active site of AChE. Oximes 22-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 21726608-1 2011 The standard treatment of intoxication with organophosphorus (OP) compounds includes the administration of oximes acting as acetylcholinesterase (AChE) reactivating antidotes. organophosphorus 44-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 21726608-1 2011 The standard treatment of intoxication with organophosphorus (OP) compounds includes the administration of oximes acting as acetylcholinesterase (AChE) reactivating antidotes. organophosphorus 44-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 21726608-1 2011 The standard treatment of intoxication with organophosphorus (OP) compounds includes the administration of oximes acting as acetylcholinesterase (AChE) reactivating antidotes. Oximes 107-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 21726608-1 2011 The standard treatment of intoxication with organophosphorus (OP) compounds includes the administration of oximes acting as acetylcholinesterase (AChE) reactivating antidotes. Oximes 107-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 21726608-7 2011 In vitro testing of the nanoparticulate oxime formulations in primary porcine brain capillary endothelial cells (pBCEC) demonstrated an up to two times higher reactivation of OP-inhibited AChE than the free oximes. Oximes 40-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-192 21771644-9 2011 Only when RBC-AChE was completely inhibited, therapy of cholinergic crisis required atropine doses up to 0.06 mg h-1 kg-1. Atropine 84-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 21795704-4 2011 Here, several lines of evidence indicate that the N-linked glycosylation of AChE(T) plays a major role for acquisition of AChE full enzymatic activity but does not affect its oligomerization. Nitrogen 50-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 21795704-4 2011 Here, several lines of evidence indicate that the N-linked glycosylation of AChE(T) plays a major role for acquisition of AChE full enzymatic activity but does not affect its oligomerization. Nitrogen 50-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 21795704-5 2011 The expression of the AChE(T) mutant, in which all N-glycosylation sites were deleted, together with PRiMA in HEK293T cells produced a glycan-depleted PRiMA-linked AChE tetramer but with a much higher K(m) value as compared with the wild type. Nitrogen 51-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 21795704-5 2011 The expression of the AChE(T) mutant, in which all N-glycosylation sites were deleted, together with PRiMA in HEK293T cells produced a glycan-depleted PRiMA-linked AChE tetramer but with a much higher K(m) value as compared with the wild type. Nitrogen 51-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 21795704-5 2011 The expression of the AChE(T) mutant, in which all N-glycosylation sites were deleted, together with PRiMA in HEK293T cells produced a glycan-depleted PRiMA-linked AChE tetramer but with a much higher K(m) value as compared with the wild type. Polysaccharides 135-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 21795704-5 2011 The expression of the AChE(T) mutant, in which all N-glycosylation sites were deleted, together with PRiMA in HEK293T cells produced a glycan-depleted PRiMA-linked AChE tetramer but with a much higher K(m) value as compared with the wild type. Polysaccharides 135-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 21803135-2 2011 To achieve this goal, oximes are administered for reactivation of inhibited acetylcholinesterase (AChE). Oximes 22-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 21803135-2 2011 To achieve this goal, oximes are administered for reactivation of inhibited acetylcholinesterase (AChE). Oximes 22-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 21803135-6 2011 30 muM HI 6 resulted in an almost complete recovery of sarin blocked muscle force and in an increase of completely inhibited muscle AChE activity to approx. asoxime chloride 7-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 21752626-0 2011 Controlled immobilization of acetylcholinesterase on improved hydrophobic gold nanoparticle/Prussian blue modified surface for ultra-trace organophosphate pesticide detection. ferric ferrocyanide 92-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 21872033-1 2011 This work describes the use of layered double hydroxides (LDHs) for the immobilisation of acetylcholinesterase (AChE) on insulator/semiconductor solid supports. layered double hydroxides 31-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 21872033-1 2011 This work describes the use of layered double hydroxides (LDHs) for the immobilisation of acetylcholinesterase (AChE) on insulator/semiconductor solid supports. layered double hydroxides 31-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 21949501-1 2011 Acetylcholinesterase (AChE; EC 3.1.1.7) plays a crucial role in the rapid hydrolysis of the neurotransmitter acetylcholine, in the central and peripheral nervous system and might also participate in non-cholinergic mechanism related to neurodegenerative diseases. Acetylcholine 109-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21949501-1 2011 Acetylcholinesterase (AChE; EC 3.1.1.7) plays a crucial role in the rapid hydrolysis of the neurotransmitter acetylcholine, in the central and peripheral nervous system and might also participate in non-cholinergic mechanism related to neurodegenerative diseases. Acetylcholine 109-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 21292041-3 2011 While the etiology of BPSD has not been clearly delineated, studies assessing the benefits of acetylcholinesterase inhibitors on BPSD suggest that some of the neuropsychiatric symptoms of dementia such as agitation, apathy and psychosis may represent a specific central cholinergic deficiency syndrome. bpsd 129-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 21286734-0 2011 Captopril modulates acetylcholinesterase in human keratinocytes. Captopril 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 21286734-2 2011 The keratinocyte acetylcholine axis is composed of the enzymes mediating acetylcholine synthesis (acetyltransferase) and degradation (acetylcholinesterase), and two classes of acetylcholine receptors. Acetylcholine 17-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 21286734-3 2011 In this study we investigated the effect of captopril, an ACE-inhibitor, on acetylcholinesterase and acetylcholine secretion in human keratinocytes. Captopril 44-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 21286734-5 2011 In addition, the effect of captopril on AChE activity was evaluated. Captopril 27-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 21286734-6 2011 We found that captopril induces a strong AChE up-regulation leading to ACh degradation and reduced secretion. Captopril 14-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 21864069-6 2011 Promising findings were provided in a monocentric randomized trial on donepezil - a reversible inhibitor of acetylcholinesterase - for the treatment of MS-related memory impairment. donepezil - a 70-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 21752626-0 2011 Controlled immobilization of acetylcholinesterase on improved hydrophobic gold nanoparticle/Prussian blue modified surface for ultra-trace organophosphate pesticide detection. Organophosphates 139-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 21752626-1 2011 An ultrasensitive amperometric acetylcholinesterase (AChE) biosensor was fabricated by controlled immobilization of AChE on gold nanoparticles/poly(dimethyldiallylammonium chloride) protected Prussian blue (Au-PDDA-PB) nanocomposite modified electrode surface for the detection of organophorous pesticide. poly-N,N-dimethyl-N,N-diallylammonium chloride 143-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 21752626-1 2011 An ultrasensitive amperometric acetylcholinesterase (AChE) biosensor was fabricated by controlled immobilization of AChE on gold nanoparticles/poly(dimethyldiallylammonium chloride) protected Prussian blue (Au-PDDA-PB) nanocomposite modified electrode surface for the detection of organophorous pesticide. poly-N,N-dimethyl-N,N-diallylammonium chloride 143-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 21752626-1 2011 An ultrasensitive amperometric acetylcholinesterase (AChE) biosensor was fabricated by controlled immobilization of AChE on gold nanoparticles/poly(dimethyldiallylammonium chloride) protected Prussian blue (Au-PDDA-PB) nanocomposite modified electrode surface for the detection of organophorous pesticide. ferric ferrocyanide 192-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 21752626-1 2011 An ultrasensitive amperometric acetylcholinesterase (AChE) biosensor was fabricated by controlled immobilization of AChE on gold nanoparticles/poly(dimethyldiallylammonium chloride) protected Prussian blue (Au-PDDA-PB) nanocomposite modified electrode surface for the detection of organophorous pesticide. ferric ferrocyanide 192-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 21752626-1 2011 An ultrasensitive amperometric acetylcholinesterase (AChE) biosensor was fabricated by controlled immobilization of AChE on gold nanoparticles/poly(dimethyldiallylammonium chloride) protected Prussian blue (Au-PDDA-PB) nanocomposite modified electrode surface for the detection of organophorous pesticide. ferric ferrocyanide 192-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 21752626-1 2011 An ultrasensitive amperometric acetylcholinesterase (AChE) biosensor was fabricated by controlled immobilization of AChE on gold nanoparticles/poly(dimethyldiallylammonium chloride) protected Prussian blue (Au-PDDA-PB) nanocomposite modified electrode surface for the detection of organophorous pesticide. au-pdda-pb 207-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 21752626-1 2011 An ultrasensitive amperometric acetylcholinesterase (AChE) biosensor was fabricated by controlled immobilization of AChE on gold nanoparticles/poly(dimethyldiallylammonium chloride) protected Prussian blue (Au-PDDA-PB) nanocomposite modified electrode surface for the detection of organophorous pesticide. au-pdda-pb 207-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 21752626-1 2011 An ultrasensitive amperometric acetylcholinesterase (AChE) biosensor was fabricated by controlled immobilization of AChE on gold nanoparticles/poly(dimethyldiallylammonium chloride) protected Prussian blue (Au-PDDA-PB) nanocomposite modified electrode surface for the detection of organophorous pesticide. au-pdda-pb 207-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 21752626-5 2011 Benefit from the advantages of the Au-PDDA-PB nanocomposite and the good activity and stability of AChE, the biosensor shows significantly improved sensitivity to monocrotophos, a typical highly toxic organophorous pesticide, with wide linear range (1.0-1000 pg/mL and 1.0-10 ng/mL) and an ultra-low detection limit of 0.8 pg/mL. au-pdda-pb 35-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 22058656-0 2011 Oxidative stress biomarkers and acetylcholinesterase activity in human erythrocytes exposed to clomazone (in vitro). clomazone 95-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 22058656-1 2011 The aim of this study was to investigate the effect of clomazone herbicide on oxidative stress biomarkers and acetylcholinesterase activity in human erythrocytes in in vitro conditions. clomazone 55-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 22058656-6 2011 These results clearly showed clomazone to induce oxidative stress and AChE inhibition in human erythrocytes (in vitro). clomazone 29-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 21941892-3 2011 Plants of the Amaryllidaceae family are known to synthesize a particular type of bioactive compounds, named Amaryllidaceae alkaloids, which have shown AChE inhibitory activity. Amaryllidaceae Alkaloids 108-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 21624391-3 2011 Thus, this study sought to determine whether rivastigmine, an acetylcholinesterase inhibitor and cognition enhancing agent, could improve neurocognitive performance in a sample of long-term, high-dose methamphetamine addicts who were not seeking treatment at the time of enrollment in the study. Rivastigmine 45-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 21470076-1 2011 For the diagnosis and therapy monitoring of intoxications with organophosphorus compounds, the determination of acetylcholinesterase (AChE) activity in whole blood is crucial. Organophosphorus Compounds 63-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 21470076-1 2011 For the diagnosis and therapy monitoring of intoxications with organophosphorus compounds, the determination of acetylcholinesterase (AChE) activity in whole blood is crucial. Organophosphorus Compounds 63-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 21470076-6 2011 A slightly higher whole blood AChE activity was recorded in DTNB samples. DTNB 60-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 21730071-0 2011 Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging. Oximes 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 21730071-0 2011 Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging. Organophosphates 60-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 21730071-1 2011 The cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase, are primary targets of organophosphates (OPs). Organophosphates 99-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 21730071-1 2011 The cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase, are primary targets of organophosphates (OPs). Organophosphates 99-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 21738917-0 2011 TiO2-decorated graphene nanohybrids for fabricating an amperometric acetylcholinesterase biosensor. titanium dioxide 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 21738917-0 2011 TiO2-decorated graphene nanohybrids for fabricating an amperometric acetylcholinesterase biosensor. Graphite 15-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 21738917-1 2011 This work describes a highly sensitive and rapid amperometric biosensor for organophosphate compounds (OPs) based on immobilization of acetylcholinesterase (AChE) on a novel TiO(2)-decorated graphene (TiO(2)-G) nanohybrid, which was constructed by in situ growth of TiO(2) nanoparticles (NPs) on the graphene sheet. organophosphate compounds 76-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 21738917-1 2011 This work describes a highly sensitive and rapid amperometric biosensor for organophosphate compounds (OPs) based on immobilization of acetylcholinesterase (AChE) on a novel TiO(2)-decorated graphene (TiO(2)-G) nanohybrid, which was constructed by in situ growth of TiO(2) nanoparticles (NPs) on the graphene sheet. organophosphate compounds 76-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 21738917-1 2011 This work describes a highly sensitive and rapid amperometric biosensor for organophosphate compounds (OPs) based on immobilization of acetylcholinesterase (AChE) on a novel TiO(2)-decorated graphene (TiO(2)-G) nanohybrid, which was constructed by in situ growth of TiO(2) nanoparticles (NPs) on the graphene sheet. OPS 103-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 21738917-1 2011 This work describes a highly sensitive and rapid amperometric biosensor for organophosphate compounds (OPs) based on immobilization of acetylcholinesterase (AChE) on a novel TiO(2)-decorated graphene (TiO(2)-G) nanohybrid, which was constructed by in situ growth of TiO(2) nanoparticles (NPs) on the graphene sheet. OPS 103-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 21738917-1 2011 This work describes a highly sensitive and rapid amperometric biosensor for organophosphate compounds (OPs) based on immobilization of acetylcholinesterase (AChE) on a novel TiO(2)-decorated graphene (TiO(2)-G) nanohybrid, which was constructed by in situ growth of TiO(2) nanoparticles (NPs) on the graphene sheet. titanium dioxide 174-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 21738917-1 2011 This work describes a highly sensitive and rapid amperometric biosensor for organophosphate compounds (OPs) based on immobilization of acetylcholinesterase (AChE) on a novel TiO(2)-decorated graphene (TiO(2)-G) nanohybrid, which was constructed by in situ growth of TiO(2) nanoparticles (NPs) on the graphene sheet. titanium dioxide 174-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 21738917-1 2011 This work describes a highly sensitive and rapid amperometric biosensor for organophosphate compounds (OPs) based on immobilization of acetylcholinesterase (AChE) on a novel TiO(2)-decorated graphene (TiO(2)-G) nanohybrid, which was constructed by in situ growth of TiO(2) nanoparticles (NPs) on the graphene sheet. Graphite 191-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 21738917-1 2011 This work describes a highly sensitive and rapid amperometric biosensor for organophosphate compounds (OPs) based on immobilization of acetylcholinesterase (AChE) on a novel TiO(2)-decorated graphene (TiO(2)-G) nanohybrid, which was constructed by in situ growth of TiO(2) nanoparticles (NPs) on the graphene sheet. Graphite 191-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 21738917-1 2011 This work describes a highly sensitive and rapid amperometric biosensor for organophosphate compounds (OPs) based on immobilization of acetylcholinesterase (AChE) on a novel TiO(2)-decorated graphene (TiO(2)-G) nanohybrid, which was constructed by in situ growth of TiO(2) nanoparticles (NPs) on the graphene sheet. titanium dioxide 201-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 21738917-1 2011 This work describes a highly sensitive and rapid amperometric biosensor for organophosphate compounds (OPs) based on immobilization of acetylcholinesterase (AChE) on a novel TiO(2)-decorated graphene (TiO(2)-G) nanohybrid, which was constructed by in situ growth of TiO(2) nanoparticles (NPs) on the graphene sheet. titanium dioxide 201-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 21738917-1 2011 This work describes a highly sensitive and rapid amperometric biosensor for organophosphate compounds (OPs) based on immobilization of acetylcholinesterase (AChE) on a novel TiO(2)-decorated graphene (TiO(2)-G) nanohybrid, which was constructed by in situ growth of TiO(2) nanoparticles (NPs) on the graphene sheet. Graphite 300-308 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 21730071-1 2011 The cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase, are primary targets of organophosphates (OPs). Organophosphates 117-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 21738917-1 2011 This work describes a highly sensitive and rapid amperometric biosensor for organophosphate compounds (OPs) based on immobilization of acetylcholinesterase (AChE) on a novel TiO(2)-decorated graphene (TiO(2)-G) nanohybrid, which was constructed by in situ growth of TiO(2) nanoparticles (NPs) on the graphene sheet. Graphite 300-308 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 21730071-1 2011 The cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase, are primary targets of organophosphates (OPs). Organophosphates 117-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 21738917-4 2011 Further, based on the inhibition of OPs on the enzymatic activity of the immobilized AChE, and using carbaryl as a model compound, the inhibition of carbaryl was proportional to its concentration ranging from 0.001 to 0.015 and 0.015 to 2 mug mL(-1) with a detection limit of 0.3 ng mL(-1) (S/N = 3). Carbaryl 101-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 21738917-4 2011 Further, based on the inhibition of OPs on the enzymatic activity of the immobilized AChE, and using carbaryl as a model compound, the inhibition of carbaryl was proportional to its concentration ranging from 0.001 to 0.015 and 0.015 to 2 mug mL(-1) with a detection limit of 0.3 ng mL(-1) (S/N = 3). Carbaryl 149-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 21730071-5 2011 Here, we characterize 10 human (h) AChE mutants that, when coupled with an oxime, give rise to catalytic reactivation and aging resistance of the soman conjugate. Oximes 75-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 21605992-0 2011 Probing the reactivation process of sarin-inhibited acetylcholinesterase with alpha-nucleophiles: hydroxylamine anion is predicted to be a better antidote with DFT calculations. hydroxylamine anion 98-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 21730071-6 2011 With the most efficient human AChE mutant Y337A/F338A, we show enhanced reactivation rates for several OP-hAChE conjugates compared with wild-type hAChE when reactivated with HI-6 (1-(2"-hydroxyiminomethyl-1"-pyridinium)-3-(4"-carbamoyl-1-pyridinium)). asoxime chloride 175-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 22006717-6 2011 Acetylcholinesterase (AChE) inhibition and cytotoxicity tests against five human cancer cell lines showed that only rhodanthenone D (4) and mangiferin (12) exhibited 18.4 and 13.4% of AChE inhibitory effects at a concentration of 10(-4) M, respectively, while compounds 1-5 and the known xanthones lancerin (11), mangiferin (12), and neomangiferin (13) displayed no cytotoxicity at a concentration of 40 muM. mangiferin 140-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-188 21115064-5 2011 During the active phase, the activity of the ACh synthesizing enzyme Choline Acetyltransferase (ChAT) is enhanced, and the activity of the ACh degrading enzyme Acetylcholinesterase (AChE) is reduced. Acetylcholine 45-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-186 21115064-5 2011 During the active phase, the activity of the ACh synthesizing enzyme Choline Acetyltransferase (ChAT) is enhanced, and the activity of the ACh degrading enzyme Acetylcholinesterase (AChE) is reduced. Acetylcholine 139-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-180 21115064-5 2011 During the active phase, the activity of the ACh synthesizing enzyme Choline Acetyltransferase (ChAT) is enhanced, and the activity of the ACh degrading enzyme Acetylcholinesterase (AChE) is reduced. Acetylcholine 139-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-186 21829148-4 2011 In the present paper, we review the multiple activities of berberine, including antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitory, monoamine oxidase inhibitory, amyloid-b peptide level-reducing and cholesterol-lowering activities, which suggest that berberine may act as a promising multipotent agent to combat AD. Berberine 59-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 20880294-4 2011 RESULTS: Donepezil and galantamine groups showed a significant increase in CSF AChE activity at follow-up, while no changes for BChE activity were observed; in donepezil group, a positive correlation between plasma concentration and AChE activity was documented. Donepezil 9-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 20880294-4 2011 RESULTS: Donepezil and galantamine groups showed a significant increase in CSF AChE activity at follow-up, while no changes for BChE activity were observed; in donepezil group, a positive correlation between plasma concentration and AChE activity was documented. Donepezil 9-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-237 20880294-4 2011 RESULTS: Donepezil and galantamine groups showed a significant increase in CSF AChE activity at follow-up, while no changes for BChE activity were observed; in donepezil group, a positive correlation between plasma concentration and AChE activity was documented. Galantamine 23-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 20880294-4 2011 RESULTS: Donepezil and galantamine groups showed a significant increase in CSF AChE activity at follow-up, while no changes for BChE activity were observed; in donepezil group, a positive correlation between plasma concentration and AChE activity was documented. Galantamine 23-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-237 20880294-4 2011 RESULTS: Donepezil and galantamine groups showed a significant increase in CSF AChE activity at follow-up, while no changes for BChE activity were observed; in donepezil group, a positive correlation between plasma concentration and AChE activity was documented. Donepezil 160-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-237 21621811-0 2011 Synthesis and biological activity of derivatives of tetrahydroacridine as acetylcholinesterase inhibitors. 1,2,3,4-Tetrahydroacridine 52-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 21621811-3 2011 The main class of medicines which are applied in AD is acetylcholinesterase inhibitors (AChEIs) like tacrine, donepezil, galantamine and rivastigmine that do not contribute to significant and long-term improvement in cognitive and behavioural functions. Tacrine 101-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 21621811-3 2011 The main class of medicines which are applied in AD is acetylcholinesterase inhibitors (AChEIs) like tacrine, donepezil, galantamine and rivastigmine that do not contribute to significant and long-term improvement in cognitive and behavioural functions. Donepezil 110-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 21621811-3 2011 The main class of medicines which are applied in AD is acetylcholinesterase inhibitors (AChEIs) like tacrine, donepezil, galantamine and rivastigmine that do not contribute to significant and long-term improvement in cognitive and behavioural functions. Galantamine 121-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 21570751-0 2011 Synthesis, biological activity and HPLC validation of 1,2,3,4-tetrahydroacridine derivatives as acetylcholinesterase inhibitors. 1,2,3,4-Tetrahydroacridine 54-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 21570751-1 2011 The synthesis and biochemical evaluation of new hybrids of tacrine (THA) and 4-fluorobenzoic acid (4-FBA) possessing activity towards acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition are presented. Tacrine 59-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 21570751-1 2011 The synthesis and biochemical evaluation of new hybrids of tacrine (THA) and 4-fluorobenzoic acid (4-FBA) possessing activity towards acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition are presented. Tacrine 68-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 21570751-1 2011 The synthesis and biochemical evaluation of new hybrids of tacrine (THA) and 4-fluorobenzoic acid (4-FBA) possessing activity towards acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition are presented. 4-fluorobenzoic acid 77-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 21570751-1 2011 The synthesis and biochemical evaluation of new hybrids of tacrine (THA) and 4-fluorobenzoic acid (4-FBA) possessing activity towards acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition are presented. 4-fluorobenzoic acid 99-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 21067438-0 2011 Bifunctional phenolic-choline conjugates as anti-oxidants and acetylcholinesterase inhibitors. Choline 22-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 21067438-4 2011 Specifically, a series of naturally occurring phenolic acids with recognized anti-oxidant properties (derivatives of caffeic acid, rosmarinic acid, and trolox) have been conjugated with choline to account for the recognition by acetylcholinesterase (AChE). phenolic acid 46-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 228-248 21067438-4 2011 Specifically, a series of naturally occurring phenolic acids with recognized anti-oxidant properties (derivatives of caffeic acid, rosmarinic acid, and trolox) have been conjugated with choline to account for the recognition by acetylcholinesterase (AChE). phenolic acid 46-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 250-254 21067438-4 2011 Specifically, a series of naturally occurring phenolic acids with recognized anti-oxidant properties (derivatives of caffeic acid, rosmarinic acid, and trolox) have been conjugated with choline to account for the recognition by acetylcholinesterase (AChE). caffeic acid 117-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 228-248 21067438-4 2011 Specifically, a series of naturally occurring phenolic acids with recognized anti-oxidant properties (derivatives of caffeic acid, rosmarinic acid, and trolox) have been conjugated with choline to account for the recognition by acetylcholinesterase (AChE). rosmarinic acid 131-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 228-248 21067438-4 2011 Specifically, a series of naturally occurring phenolic acids with recognized anti-oxidant properties (derivatives of caffeic acid, rosmarinic acid, and trolox) have been conjugated with choline to account for the recognition by acetylcholinesterase (AChE). 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 152-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 228-248 21067438-4 2011 Specifically, a series of naturally occurring phenolic acids with recognized anti-oxidant properties (derivatives of caffeic acid, rosmarinic acid, and trolox) have been conjugated with choline to account for the recognition by acetylcholinesterase (AChE). Choline 186-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 228-248 21067438-4 2011 Specifically, a series of naturally occurring phenolic acids with recognized anti-oxidant properties (derivatives of caffeic acid, rosmarinic acid, and trolox) have been conjugated with choline to account for the recognition by acetylcholinesterase (AChE). Choline 186-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 250-254 21570330-1 2011 The acetylcholinesterase (AChE) is important to terminate acetylcholine-mediated neurotransmission at cholinergic synapses. Acetylcholine 4-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 21570330-4 2011 The hCyt c was bound to peripheral anionic site (PAS) on hAChE and binding mode of the docked conformation was very similar to the reported crystal structure of the AChE and fasciculin-II (Fas-II) complex. hcyt c 4-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-62 21570330-4 2011 The hCyt c was bound to peripheral anionic site (PAS) on hAChE and binding mode of the docked conformation was very similar to the reported crystal structure of the AChE and fasciculin-II (Fas-II) complex. hcyt c 4-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 21570330-4 2011 The hCyt c was bound to peripheral anionic site (PAS) on hAChE and binding mode of the docked conformation was very similar to the reported crystal structure of the AChE and fasciculin-II (Fas-II) complex. Aminosalicylic Acid 49-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-62 21570330-4 2011 The hCyt c was bound to peripheral anionic site (PAS) on hAChE and binding mode of the docked conformation was very similar to the reported crystal structure of the AChE and fasciculin-II (Fas-II) complex. Aminosalicylic Acid 49-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 21605992-1 2011 Inactivation of acetylcholinesterase (AChE) due to inhibition by organophosphorus (OP) compounds is a major threat to human since AChE is a key enzyme in neurotransmission process. organophosphorus 65-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 21605992-1 2011 Inactivation of acetylcholinesterase (AChE) due to inhibition by organophosphorus (OP) compounds is a major threat to human since AChE is a key enzyme in neurotransmission process. organophosphorus 65-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 21605992-1 2011 Inactivation of acetylcholinesterase (AChE) due to inhibition by organophosphorus (OP) compounds is a major threat to human since AChE is a key enzyme in neurotransmission process. organophosphorus 65-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 21605992-2 2011 Oximes are used as potential reactivators of OP-inhibited AChE due to their alpha-effect nucleophilic reactivity. Oximes 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 21605992-4 2011 We report the importance of alpha-effect of nucleophilic reactivity towards the reactivation of OP-inhibited AChE with hydroxylamine anion. hydroxylamine anion 119-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 21605992-6 2011 The superiority of hydroxylamine anion to reactivate the sarin-inhibited AChE with sarin-serine adducts 3 and 4 compared to formoximate anion was observed in the presence and absence of hydrogen bonding interactions of Gly121 and Gly122. hydroxylamine anion 19-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 21605992-6 2011 The superiority of hydroxylamine anion to reactivate the sarin-inhibited AChE with sarin-serine adducts 3 and 4 compared to formoximate anion was observed in the presence and absence of hydrogen bonding interactions of Gly121 and Gly122. Serine 89-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 21605992-6 2011 The superiority of hydroxylamine anion to reactivate the sarin-inhibited AChE with sarin-serine adducts 3 and 4 compared to formoximate anion was observed in the presence and absence of hydrogen bonding interactions of Gly121 and Gly122. formoximate anion 124-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 20937617-5 2011 The essential oil was a potent inhibitor of human acetylcholinesterase (AChE) and consisted almost exclusively of monoterpenoids. Oils, Volatile 4-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 20937617-5 2011 The essential oil was a potent inhibitor of human acetylcholinesterase (AChE) and consisted almost exclusively of monoterpenoids. Oils, Volatile 4-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 21645691-0 2011 Acetylcholinesterase biosensor based on single-walled carbon nanotubes--Co phtalocyanine for organophosphorus pesticides detection. Carbon 54-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21645691-0 2011 Acetylcholinesterase biosensor based on single-walled carbon nanotubes--Co phtalocyanine for organophosphorus pesticides detection. co phtalocyanine 72-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21645691-0 2011 Acetylcholinesterase biosensor based on single-walled carbon nanotubes--Co phtalocyanine for organophosphorus pesticides detection. organophosphorus 93-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21645691-1 2011 A simple and reliable technique has been developed for the construction of an amperometric acetylcholinesterase biosensor based on screen-printed carbon electrodes. Carbon 146-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 21682268-2 2011 In this study we compared the active sites of monomers and tetramers of human BChE and human AChE after performing molecular dynamics (MD) simulations in water-solvated systems. Water 154-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 21514354-6 2011 PBPK/PD model simulations estimated that a 4-fold increase or decrease in relative CYP2B6 and CYP2C19 content would produce a 9-22% inhibition in blood AChE activity following exposure of an adult to chlorpyrifos (1000 mug/kg). Chlorpyrifos 200-212 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 21514354-7 2011 Similar model simulation produced an 18-22% inhibition in blood AChE activity following exposure of an adult to parathion (25 mug/kg). Parathion 112-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 21591743-3 2011 This is the first report of AChE encapsulated in monolithic silica for use as an immobilized enzyme reactor (IMER), and the first use of such IMERs for mixture screening. Silicon Dioxide 60-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 21286943-2 2011 Zirconia (ZrO(2)) was added in microwell for adsorption of acetylcholinesterase (AChE). zirconium oxide 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 21286943-2 2011 Zirconia (ZrO(2)) was added in microwell for adsorption of acetylcholinesterase (AChE). zirconium oxide 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 21286943-2 2011 Zirconia (ZrO(2)) was added in microwell for adsorption of acetylcholinesterase (AChE). zro(2) 10-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 21286943-2 2011 Zirconia (ZrO(2)) was added in microwell for adsorption of acetylcholinesterase (AChE). zro(2) 10-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 21747136-9 2011 Acetylcholinesterase is inhibited by the nerve gas sarin and by organophosphate pesticides. Organophosphates 64-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21570330-6 2011 The key hydrogen bonding residues between hAChE and hCyt c proteins were found in Apo and Holo systems, as well as each Tyr341 and Trp286 residue of hAChE was participated in cation-pi (pi) interactions with Lys79 of hCyt c in Apo and Holo systems, respectively. Hydrogen 8-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-47 20027669-0 2011 Design, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides. organophosphorus 96-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 21570330-6 2011 The key hydrogen bonding residues between hAChE and hCyt c proteins were found in Apo and Holo systems, as well as each Tyr341 and Trp286 residue of hAChE was participated in cation-pi (pi) interactions with Lys79 of hCyt c in Apo and Holo systems, respectively. Hydrogen 8-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-154 21570330-6 2011 The key hydrogen bonding residues between hAChE and hCyt c proteins were found in Apo and Holo systems, as well as each Tyr341 and Trp286 residue of hAChE was participated in cation-pi (pi) interactions with Lys79 of hCyt c in Apo and Holo systems, respectively. hcyt c 52-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-154 21493754-10 2011 Protein expression of ACHE nonsynonymous variant D134H (SNP6) is impaired: this variant shows compromised stability and altered rates of organophosphate inhibition and oxime-assisted reactivation. Organophosphates 137-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 21493754-10 2011 Protein expression of ACHE nonsynonymous variant D134H (SNP6) is impaired: this variant shows compromised stability and altered rates of organophosphate inhibition and oxime-assisted reactivation. Oximes 168-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 20027669-5 2011 Commercial AChE reactivators (e.g. pralidoxime, HI-6, obidoxime, trimedoxime, methoxime) were originally developed for other members of the organophosphate family, such as nerve agents (e.g. sarin, soman, tabun, VX). pralidoxime 35-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-15 20027669-5 2011 Commercial AChE reactivators (e.g. pralidoxime, HI-6, obidoxime, trimedoxime, methoxime) were originally developed for other members of the organophosphate family, such as nerve agents (e.g. sarin, soman, tabun, VX). asoxime chloride 48-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-15 20027669-5 2011 Commercial AChE reactivators (e.g. pralidoxime, HI-6, obidoxime, trimedoxime, methoxime) were originally developed for other members of the organophosphate family, such as nerve agents (e.g. sarin, soman, tabun, VX). Obidoxime Chloride 54-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-15 20027669-5 2011 Commercial AChE reactivators (e.g. pralidoxime, HI-6, obidoxime, trimedoxime, methoxime) were originally developed for other members of the organophosphate family, such as nerve agents (e.g. sarin, soman, tabun, VX). Trimedoxime 65-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-15 20027669-5 2011 Commercial AChE reactivators (e.g. pralidoxime, HI-6, obidoxime, trimedoxime, methoxime) were originally developed for other members of the organophosphate family, such as nerve agents (e.g. sarin, soman, tabun, VX). N,N'-monomethylenebis(pyridiniumaldoxime) 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-15 20027669-5 2011 Commercial AChE reactivators (e.g. pralidoxime, HI-6, obidoxime, trimedoxime, methoxime) were originally developed for other members of the organophosphate family, such as nerve agents (e.g. sarin, soman, tabun, VX). Organophosphates 140-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-15 20027669-6 2011 Pralidoxime, HI-6, and methoxime were found to be weak reactivators of OPP-inhibited AChE. pralidoxime 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 20027669-6 2011 Pralidoxime, HI-6, and methoxime were found to be weak reactivators of OPP-inhibited AChE. asoxime chloride 13-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 20027669-6 2011 Pralidoxime, HI-6, and methoxime were found to be weak reactivators of OPP-inhibited AChE. N,N'-monomethylenebis(pyridiniumaldoxime) 23-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 21438623-3 2011 Human butyrylcholinesterase (BChE; EC 3.1.1.8) and human acetylcholinesterase (AChE; EC 3.1.1.7) are irreversibly inhibited by CBDP. CBDP 127-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 21438623-3 2011 Human butyrylcholinesterase (BChE; EC 3.1.1.8) and human acetylcholinesterase (AChE; EC 3.1.1.7) are irreversibly inhibited by CBDP. CBDP 127-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 21671540-8 2011 Memantine can also be used in combination with acetylcholinesterase inhibitors. Memantine 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 21601034-1 2011 This work reports a rapid and sensitive organophosphates (OPs) amperometric biosensor based on acetylcholinesterase (AChE) immobilized on CdS-decorated graphene (CdS-G) nanocomposite. Organophosphates 40-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 21514816-0 2011 Oxidative desorption of thiocholine assembled on core-shell Fe3O4/AuNPs magnetic nanocomposites for highly sensitive determination of acetylcholinesterase activity: an exposure biomarker of organophosphates. Thiocholine 24-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 21514816-0 2011 Oxidative desorption of thiocholine assembled on core-shell Fe3O4/AuNPs magnetic nanocomposites for highly sensitive determination of acetylcholinesterase activity: an exposure biomarker of organophosphates. ferryl iron 60-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 21514816-0 2011 Oxidative desorption of thiocholine assembled on core-shell Fe3O4/AuNPs magnetic nanocomposites for highly sensitive determination of acetylcholinesterase activity: an exposure biomarker of organophosphates. Organophosphates 190-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 21514816-1 2011 Acetylcholinesterase (AChE) activity is a well established biomarker for biomonitoring of exposures to organophosphates (OPs) pesticides and chemical nerve agents. Organophosphates 103-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21514816-1 2011 Acetylcholinesterase (AChE) activity is a well established biomarker for biomonitoring of exposures to organophosphates (OPs) pesticides and chemical nerve agents. Organophosphates 103-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 21514816-1 2011 Acetylcholinesterase (AChE) activity is a well established biomarker for biomonitoring of exposures to organophosphates (OPs) pesticides and chemical nerve agents. Organophosphates 121-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21514816-1 2011 Acetylcholinesterase (AChE) activity is a well established biomarker for biomonitoring of exposures to organophosphates (OPs) pesticides and chemical nerve agents. Organophosphates 121-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 21514816-2 2011 In this work, we described a novel electrochemical oxidative desorption-process of thiocholine, the product of enzymatic reaction, for rapid and highly sensitive determination of AChE activity in human serum. Thiocholine 83-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 179-183 21601034-1 2011 This work reports a rapid and sensitive organophosphates (OPs) amperometric biosensor based on acetylcholinesterase (AChE) immobilized on CdS-decorated graphene (CdS-G) nanocomposite. Organophosphates 40-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 21601034-1 2011 This work reports a rapid and sensitive organophosphates (OPs) amperometric biosensor based on acetylcholinesterase (AChE) immobilized on CdS-decorated graphene (CdS-G) nanocomposite. Organophosphates 58-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 21601034-1 2011 This work reports a rapid and sensitive organophosphates (OPs) amperometric biosensor based on acetylcholinesterase (AChE) immobilized on CdS-decorated graphene (CdS-G) nanocomposite. Organophosphates 58-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 21601034-1 2011 This work reports a rapid and sensitive organophosphates (OPs) amperometric biosensor based on acetylcholinesterase (AChE) immobilized on CdS-decorated graphene (CdS-G) nanocomposite. Cadmium 138-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 21601034-1 2011 This work reports a rapid and sensitive organophosphates (OPs) amperometric biosensor based on acetylcholinesterase (AChE) immobilized on CdS-decorated graphene (CdS-G) nanocomposite. Cadmium 138-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 21601034-1 2011 This work reports a rapid and sensitive organophosphates (OPs) amperometric biosensor based on acetylcholinesterase (AChE) immobilized on CdS-decorated graphene (CdS-G) nanocomposite. Graphite 152-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 21601034-1 2011 This work reports a rapid and sensitive organophosphates (OPs) amperometric biosensor based on acetylcholinesterase (AChE) immobilized on CdS-decorated graphene (CdS-G) nanocomposite. Graphite 152-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 21601034-1 2011 This work reports a rapid and sensitive organophosphates (OPs) amperometric biosensor based on acetylcholinesterase (AChE) immobilized on CdS-decorated graphene (CdS-G) nanocomposite. cds-g 162-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 21601034-1 2011 This work reports a rapid and sensitive organophosphates (OPs) amperometric biosensor based on acetylcholinesterase (AChE) immobilized on CdS-decorated graphene (CdS-G) nanocomposite. cds-g 162-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 21601034-4 2011 Based on the inhibition of OPs on the enzymatic activity of the immobilized AChE, and used carbaryl as the model compound, the resulting biosensor exhibits excellent performance for OPs detection including good reproducibility, acceptable stability, and a reliable linear relationship between the inhibition and log[carbaryl] from 2 ng mL-1 up to 2 mug mL-1 with a detection limit of 0.7 ng mL-1,which provides a new promising tool for analysis of enzyme inhibitors. Carbaryl 91-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 21601034-4 2011 Based on the inhibition of OPs on the enzymatic activity of the immobilized AChE, and used carbaryl as the model compound, the resulting biosensor exhibits excellent performance for OPs detection including good reproducibility, acceptable stability, and a reliable linear relationship between the inhibition and log[carbaryl] from 2 ng mL-1 up to 2 mug mL-1 with a detection limit of 0.7 ng mL-1,which provides a new promising tool for analysis of enzyme inhibitors. Organophosphates 27-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 21601034-4 2011 Based on the inhibition of OPs on the enzymatic activity of the immobilized AChE, and used carbaryl as the model compound, the resulting biosensor exhibits excellent performance for OPs detection including good reproducibility, acceptable stability, and a reliable linear relationship between the inhibition and log[carbaryl] from 2 ng mL-1 up to 2 mug mL-1 with a detection limit of 0.7 ng mL-1,which provides a new promising tool for analysis of enzyme inhibitors. Carbaryl 316-324 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 21464125-4 2011 Reactivation capacities of novel oximes are rank ordered by their relative reactivation rate constants at 0.67 mm compared with 2-pyridinealdoxime methiodide for reactivation of four organophosphate (sarin, cyclosarin, VX, and paraoxon) conjugates of human acetylcholinesterase (hAChE). Oximes 33-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 279-284 21315693-2 2011 In this study, the neuroprotective properties of bis(12)-hupyridone (B12H), a novel dimeric acetylcholinesterase (AChE) inhibitor modified from a naturally occurring monomeric analogue, huperzine A, on H2O2-induced neurotoxicity were investigated in cerebellar granule neurons (CGNs). bis(12)-hupyridone 49-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 21315693-2 2011 In this study, the neuroprotective properties of bis(12)-hupyridone (B12H), a novel dimeric acetylcholinesterase (AChE) inhibitor modified from a naturally occurring monomeric analogue, huperzine A, on H2O2-induced neurotoxicity were investigated in cerebellar granule neurons (CGNs). bis(12)-hupyridone 69-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 21464125-6 2011 The 10 best reactivating oximes, predominantly hydroxyimino acetamide derivatives (for hAChE) and imidazole-containing aldoximes (for hBChE) also exhibited reasonable activity in the reactivation of tabun conjugates. Oximes 25-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-92 21464125-6 2011 The 10 best reactivating oximes, predominantly hydroxyimino acetamide derivatives (for hAChE) and imidazole-containing aldoximes (for hBChE) also exhibited reasonable activity in the reactivation of tabun conjugates. hydroxyimino acetamide 47-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-92 21464125-7 2011 Reactivation kinetics of the lead hydroxyimino acetamide reactivator of hAChE, when analyzed in terms of apparent affinity (1/K(ox)) and maximum reactivation rate (k(2)), is superior to the reference uncharged reactivators monoisonitrosoacetone and 2,3-butanedione monoxime and shows potential for further refinement. hydroxyimino acetamide 34-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-77 21464125-7 2011 Reactivation kinetics of the lead hydroxyimino acetamide reactivator of hAChE, when analyzed in terms of apparent affinity (1/K(ox)) and maximum reactivation rate (k(2)), is superior to the reference uncharged reactivators monoisonitrosoacetone and 2,3-butanedione monoxime and shows potential for further refinement. isonitrosoacetone 223-244 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-77 21464125-7 2011 Reactivation kinetics of the lead hydroxyimino acetamide reactivator of hAChE, when analyzed in terms of apparent affinity (1/K(ox)) and maximum reactivation rate (k(2)), is superior to the reference uncharged reactivators monoisonitrosoacetone and 2,3-butanedione monoxime and shows potential for further refinement. diacetylmonoxime 249-273 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-77 21838142-0 2011 The inhibition activity of selected beta-carboline alkaloids on enzymes of acetylcholinesterase and butyrylcholinesterase. beta-carboline alkaloids 36-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 21838142-1 2011 This thesis deals with testing of inhibition activity beta-carboline alkaloids on activity of enzymes acetylcholinesterase (ACHE) and butyrylcholinesterase (BUCHE) using test "Fast Blue B salt" at TLC desk and Ellman"s test using spectrophotometer. beta-carboline alkaloids 54-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 21838142-1 2011 This thesis deals with testing of inhibition activity beta-carboline alkaloids on activity of enzymes acetylcholinesterase (ACHE) and butyrylcholinesterase (BUCHE) using test "Fast Blue B salt" at TLC desk and Ellman"s test using spectrophotometer. beta-carboline alkaloids 54-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 21838142-3 2011 Results show harmine in form of base and salt in water and in mixture of DMSO and water has the hightest inhibition activity on ACHE using eserine as reference substance. Harmine 13-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 21838142-3 2011 Results show harmine in form of base and salt in water and in mixture of DMSO and water has the hightest inhibition activity on ACHE using eserine as reference substance. Salts 41-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 21838142-3 2011 Results show harmine in form of base and salt in water and in mixture of DMSO and water has the hightest inhibition activity on ACHE using eserine as reference substance. Water 49-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 21838142-3 2011 Results show harmine in form of base and salt in water and in mixture of DMSO and water has the hightest inhibition activity on ACHE using eserine as reference substance. Dimethyl Sulfoxide 73-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 21838142-3 2011 Results show harmine in form of base and salt in water and in mixture of DMSO and water has the hightest inhibition activity on ACHE using eserine as reference substance. Water 82-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 21224175-8 2011 We observed a statistically significant inverse correlation between urinary TCPy and blood BuChE and AChE activities. 3,5,6-trichloro-2-pyridinol 76-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 21224175-10 2011 CONCLUSIONS: Our findings demonstrate a dose-effect relationship between urinary TCPy and both plasma BuChE and red blood cell AChE in humans exposed occupationally to CPF. 3,5,6-trichloro-2-pyridinol 81-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 21707398-2 2011 One pharmacological approach is to restore acetylcholine level by inhibiting acetylcholinesterase (AChE) with reversible inhibitors, such as galanthamine, thus helping to improve the cognitive symptoms of the disease. Acetylcholine 43-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 21435752-0 2011 New potent human acetylcholinesterase inhibitors in the tetracyclic triterpene series with inhibitory potency on amyloid beta aggregation. Triterpenes 68-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 21435752-1 2011 New acetylcholinesterase inhibitors in the tetracyclic triterpene series were synthesized, tested in vitro for the inhibition of cholinesterases (different sources of AChE and BuChE) and for the ability to prevent AChE-induced Abeta aggregation. Triterpenes 55-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 20807084-0 2011 Hyperbolic mixed-type inhibition of acetylcholinesterase by tetracyclic thienopyrimidines. thienopyrimidine 72-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 20807084-1 2011 A series of tetracyclic thienopyrimidines (7-14) was prepared and investigated as inhibitors of acetylcholinesterase from Electrophorus electricus acetylcholinesterase (EeAChE), as well as human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE). tetracyclic thienopyrimidines 12-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 20807084-1 2011 A series of tetracyclic thienopyrimidines (7-14) was prepared and investigated as inhibitors of acetylcholinesterase from Electrophorus electricus acetylcholinesterase (EeAChE), as well as human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE). tetracyclic thienopyrimidines 12-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 20807084-1 2011 A series of tetracyclic thienopyrimidines (7-14) was prepared and investigated as inhibitors of acetylcholinesterase from Electrophorus electricus acetylcholinesterase (EeAChE), as well as human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE). tetracyclic thienopyrimidines 12-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 20807085-1 2011 The standard treatment of poisoning by organophosphorus compounds (OP) includes the reversible muscarine receptor antagonist atropine and oximes for the reactivation of OP-inhibited acetylcholinesterase (AChE). Organophosphorus Compounds 39-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-208 20807085-1 2011 The standard treatment of poisoning by organophosphorus compounds (OP) includes the reversible muscarine receptor antagonist atropine and oximes for the reactivation of OP-inhibited acetylcholinesterase (AChE). Atropine 125-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-208 20807085-1 2011 The standard treatment of poisoning by organophosphorus compounds (OP) includes the reversible muscarine receptor antagonist atropine and oximes for the reactivation of OP-inhibited acetylcholinesterase (AChE). Oximes 138-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-208 20807085-4 2011 These constants can be used to calculate reactivation velocities and oxime concentrations necessary for the reactivation of a desired fraction of inhibited AChE. Oximes 69-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-160 20807085-7 2011 Hereby, it has to be taken into account that an increase of affinity to OP-inhibited AChE is generally accompanied by an increased affinity to native AChE and subsequent reduction in oxime tolerance. Oximes 183-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 20807085-8 2011 Hence, future developments of more effective oximes should consider kinetic demands by attempting to achieve a certain level of reactivity and affinity, preferentially towards OP-inhibited AChE. Oximes 45-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-193 20839017-2 2011 The energies of the frontier orbitals and the distances between the more acidic hydrogen species were investigated to determine their contributions to the activity of a group of acetylcholinesterase inhibitors. Hydrogen 80-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-198 20839017-7 2011 Desirable features for acetylcholinesterase inhibitor molecules include aromatic systems or groups that simulate the surface electrostatic potential of aromatic systems and the presence of a sufficient number of hydrogen acceptors and few hydrogen donors. Hydrogen 212-220 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 20839017-7 2011 Desirable features for acetylcholinesterase inhibitor molecules include aromatic systems or groups that simulate the surface electrostatic potential of aromatic systems and the presence of a sufficient number of hydrogen acceptors and few hydrogen donors. Hydrogen 239-247 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 21185313-3 2011 Huperzine A is a reversible acetylcholinesterase (AChE) inhibitor, its administration results in regionally specific increases in acetylcholine levels in the brain. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 21185313-3 2011 Huperzine A is a reversible acetylcholinesterase (AChE) inhibitor, its administration results in regionally specific increases in acetylcholine levels in the brain. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 21185313-3 2011 Huperzine A is a reversible acetylcholinesterase (AChE) inhibitor, its administration results in regionally specific increases in acetylcholine levels in the brain. Acetylcholine 28-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 21699076-6 2011 Compound 3e showed stronger activity than the standard tacrine, and compound 3a showed activity similar to that of tacrine for AChE. Tacrine 115-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 21699076-7 2011 Compounds 3a, 3b, 3c, and 3e showed stronger activity than the standard donepezil towards the inhibition of BChE, and the compound 3e showed stronger activity than donepezil towards AChE. Donepezil 164-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-186 21669165-7 2011 In the AChE assay, Ac.Cr showed significant AChE inhibitory activity with almost complete inhibition of the enzyme. Chromium 22-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 7-11 21669165-7 2011 In the AChE assay, Ac.Cr showed significant AChE inhibitory activity with almost complete inhibition of the enzyme. Chromium 22-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 21575287-1 2011 INTRODUCTION: Acetylcholinesterase inhibition by organophosphorus pesticides or organophosphate nerve agents can cause acute parasympathetic system dysfunction, muscle weakness, seizures, coma, and respiratory failure. organophosphorus 49-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 21575287-1 2011 INTRODUCTION: Acetylcholinesterase inhibition by organophosphorus pesticides or organophosphate nerve agents can cause acute parasympathetic system dysfunction, muscle weakness, seizures, coma, and respiratory failure. Organophosphates 80-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 21481580-0 2011 Nanoparticle-based immunosensor with apoferritin templated metallic phosphate label for quantification of phosphorylated acetylcholinesterase. Phosphates 68-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 21481580-1 2011 A new sandwich-like electrochemical immunosensor has been developed for quantification of organophosphorylated acetylcholinesterase (OP-AChE), an exposure biomarker of organophosphate pesticides and nerve agents. Organophosphates 168-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 21481580-1 2011 A new sandwich-like electrochemical immunosensor has been developed for quantification of organophosphorylated acetylcholinesterase (OP-AChE), an exposure biomarker of organophosphate pesticides and nerve agents. Organophosphates 168-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 21481580-2 2011 Zirconia nanoparticles (ZrO2 NPs) were anchored on a screen printed electrode (SPE) to preferably capture OP-AChE adducts by metal chelation with phospho-moieties, which was selectively recognized by lead phosphate-apoferritin labeled anti-AChE antibody (LPA-anti-AChE). Metals 125-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 21402092-0 2011 Pre- and post-treatment effect of physostigmine on soman-inhibited human erythrocyte and muscle acetylcholinesterase in vitro. Physostigmine 34-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 21402092-2 2011 However, successful oxime treatment in soman poisoning is limited due to rapid aging of phosphylated acetylcholinesterase (AChE). Oximes 20-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 21402092-2 2011 However, successful oxime treatment in soman poisoning is limited due to rapid aging of phosphylated acetylcholinesterase (AChE). Oximes 20-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 21402092-5 2011 The present study was performed to investigate a possible pre- and post-treatment effect of physostigmine on soman-inhibited human AChE given at different time intervals before or after perfusion with soman by using a well-established dynamically working in vitro model for real-time analysis of erythrocyte and muscle AChE. Physostigmine 92-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 21402092-6 2011 The major findings were that prophylactic physostigmine prevented complete inhibition of AChE by soman and resulted in partial spontaneous recovery of the enzyme by de-carbamylation. Physostigmine 42-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 21402092-7 2011 Physostigmine given as post-treatment resulted in a time-dependent reduction of the protection from soman inhibition and recovery of AChE. Physostigmine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 21451868-1 2011 Nerve agents are highly toxic organophosphorus compounds with strong inhibition potency against acetylcholinesterase (AChE). Organophosphorus Compounds 30-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 21451868-1 2011 Nerve agents are highly toxic organophosphorus compounds with strong inhibition potency against acetylcholinesterase (AChE). Organophosphorus Compounds 30-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 21451868-2 2011 Herein, we describe two first extremely promising uncharged reactivators for poisoned human AChE with a superior or similar in vitro ability to reactivate the enzyme as compared to that of HI-6, obidoxime, TMB-4 and HLo-7. asoxime chloride 189-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 21454498-1 2011 Nerve agents are chiral organophosphate compounds (OPs) that exert their acute toxicity by phosphorylating the catalytic serine of acetylcholinesterase (AChE). organophosphate compounds 24-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-151 21454498-1 2011 Nerve agents are chiral organophosphate compounds (OPs) that exert their acute toxicity by phosphorylating the catalytic serine of acetylcholinesterase (AChE). organophosphate compounds 24-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 21454498-1 2011 Nerve agents are chiral organophosphate compounds (OPs) that exert their acute toxicity by phosphorylating the catalytic serine of acetylcholinesterase (AChE). OPS 51-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-151 21454498-1 2011 Nerve agents are chiral organophosphate compounds (OPs) that exert their acute toxicity by phosphorylating the catalytic serine of acetylcholinesterase (AChE). OPS 51-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 21344648-0 2011 New huprine derivatives functionalized at position 9 as highly potent acetylcholinesterase inhibitors. huprine 4-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 21344648-1 2011 A series of 24 huprine derivatives diversely functionalized at position 9 have been synthesized and evaluated for their inhibitory activity against human recombinant acetylcholinesterase (AChE). huprine 15-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-186 21344648-1 2011 A series of 24 huprine derivatives diversely functionalized at position 9 have been synthesized and evaluated for their inhibitory activity against human recombinant acetylcholinesterase (AChE). huprine 15-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-192 21216144-0 2011 (+)-Arisugacin A--computational evidence of a dual binding site covalent inhibitor of acetylcholinesterase. arisugacin A 4-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 21216144-2 2011 The model suggests that (+)-arisugacin A is a dual binding site covalent inhibitor of AChE. arisugacin A 28-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 21397996-4 2011 These dual binding inhibitors, being able to interact both with the peripheral anionic site (PAS) of AChE and the catalytic subsite, proved to be able to inhibit the AChE-induced Abeta aggregation. Aminosalicylic Acid 93-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 21397996-4 2011 These dual binding inhibitors, being able to interact both with the peripheral anionic site (PAS) of AChE and the catalytic subsite, proved to be able to inhibit the AChE-induced Abeta aggregation. Aminosalicylic Acid 93-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 21707398-2 2011 One pharmacological approach is to restore acetylcholine level by inhibiting acetylcholinesterase (AChE) with reversible inhibitors, such as galanthamine, thus helping to improve the cognitive symptoms of the disease. Acetylcholine 43-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 21707398-2 2011 One pharmacological approach is to restore acetylcholine level by inhibiting acetylcholinesterase (AChE) with reversible inhibitors, such as galanthamine, thus helping to improve the cognitive symptoms of the disease. Galantamine 141-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 21707398-2 2011 One pharmacological approach is to restore acetylcholine level by inhibiting acetylcholinesterase (AChE) with reversible inhibitors, such as galanthamine, thus helping to improve the cognitive symptoms of the disease. Galantamine 141-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 21354413-5 2011 The determination of the inhibition kinetics of pyridostigmine, malaoxon and chlorpyrifos oxon with hAChE in the presence of 5mM DEET resulted in a moderate reduction of the inhibition rate constant k(i). Chlorpyrifos 77-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-105 21553703-1 2011 Drugs currently approved by the U.S. Food and Drug Administration (FDA) for the treatment of Alzheimer"s disease include acetylcholinesterase inhibitor (i.e., tacrine, donepezil, rivastigmine, and galantamine) and glutamate-modulating (i.e., memantine) drugs. Tacrine 159-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 21397406-0 2011 Combining carbamazepine, neuroleptics and acetylcholinesterase inhibitors with methylphenidate only reduces adverse side effects, but is less effective than a combination with atomoxetine. Methylphenidate 79-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 21730071-6 2011 With the most efficient human AChE mutant Y337A/F338A, we show enhanced reactivation rates for several OP-hAChE conjugates compared with wild-type hAChE when reactivated with HI-6 (1-(2"-hydroxyiminomethyl-1"-pyridinium)-3-(4"-carbamoyl-1-pyridinium)). 1-(2"-hydroxyiminomethyl-1"-pyridinium)-3-(4"-carbamoyl-1-pyridinium 181-249 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 21354413-6 2011 The decarbamoylation velocity of pyridostigmine-inhibited hAChE was not affected by DEET. Pyridostigmine Bromide 33-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-63 21354413-7 2011 In conclusion, the in vitro investigation of interactions between human cholinesterases, DEET, pyridostigmine, malaoxon and chlorpyrifos oxon showed a weak inhibition of hAChE and hBChE by DEET. Pyridostigmine Bromide 95-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-175 21354413-7 2011 In conclusion, the in vitro investigation of interactions between human cholinesterases, DEET, pyridostigmine, malaoxon and chlorpyrifos oxon showed a weak inhibition of hAChE and hBChE by DEET. malaoxon 111-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-175 21354413-7 2011 In conclusion, the in vitro investigation of interactions between human cholinesterases, DEET, pyridostigmine, malaoxon and chlorpyrifos oxon showed a weak inhibition of hAChE and hBChE by DEET. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 124-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-175 21397501-1 2011 This paper describes the preparation and in vitro evaluation of 18 newly prepared bis-quinolinium inhibitors on human recombinant acetylcholinesterase (AChE) and human plasmatic butyrylcholinesterase (BChE). bis-quinolinium 82-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 21354413-2 2011 However, human in vitro data on interactions of DEET with other compounds are scarce and provoked the present in vitro study scrutinizing the interactions of DEET, pyridostigmine and pesticides with human acetylcholinesterase (hAChE) and butyrylcholinesterase (hBChE). Pyridostigmine Bromide 164-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 227-232 21354413-5 2011 The determination of the inhibition kinetics of pyridostigmine, malaoxon and chlorpyrifos oxon with hAChE in the presence of 5mM DEET resulted in a moderate reduction of the inhibition rate constant k(i). Pyridostigmine Bromide 48-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-105 21354413-5 2011 The determination of the inhibition kinetics of pyridostigmine, malaoxon and chlorpyrifos oxon with hAChE in the presence of 5mM DEET resulted in a moderate reduction of the inhibition rate constant k(i). malaoxon 64-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-105 21397501-1 2011 This paper describes the preparation and in vitro evaluation of 18 newly prepared bis-quinolinium inhibitors on human recombinant acetylcholinesterase (AChE) and human plasmatic butyrylcholinesterase (BChE). bis-quinolinium 82-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 21397501-3 2011 One novel compound was found to be a promising inhibitor of hAChE (in nM range) and was better than edrophonium chloride or BW284c51, but was worse than ambenonium chloride. Edrophonium 100-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-65 21615017-5 2011 (+)-Canadaline inhibited acetylcholinesterase as well as butyrylcholinesterase in a dose-dependent manner with IC50 values of 20.1 +/- 1.1 microM and 85.2 +/- 3.2 microM, respectively. (+)-canadaline 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 21376964-2 2011 Under the catalytic effect of acetylcholinesterase (AChE), acetylthiocholine (ATCh) hydrolysis released thiocholine (TCh) which could react with N-(7-dimethylamino-4-methylcoumarin-3-yl) maleimide (DACM) to produce a blue fluorescence compound. Acetylthiocholine 59-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 21615017-6 2011 (+)-Canadine, with an IC50 value of 12.4 +/- 0.9 microM, was the most potent inhibitor of acetylcholinesterase, whilst (+/-)-corycavidine and (+)-bulbocapnine were effective inhibitors of butyrylcholinesterase with IC50 values of 46.2 +/- 2.4 microM and 67.0 +/- 2.1 microM, respectively. canadine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 21376964-2 2011 Under the catalytic effect of acetylcholinesterase (AChE), acetylthiocholine (ATCh) hydrolysis released thiocholine (TCh) which could react with N-(7-dimethylamino-4-methylcoumarin-3-yl) maleimide (DACM) to produce a blue fluorescence compound. Acetylthiocholine 59-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 21376964-2 2011 Under the catalytic effect of acetylcholinesterase (AChE), acetylthiocholine (ATCh) hydrolysis released thiocholine (TCh) which could react with N-(7-dimethylamino-4-methylcoumarin-3-yl) maleimide (DACM) to produce a blue fluorescence compound. Acetylthiocholine 78-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 21376964-2 2011 Under the catalytic effect of acetylcholinesterase (AChE), acetylthiocholine (ATCh) hydrolysis released thiocholine (TCh) which could react with N-(7-dimethylamino-4-methylcoumarin-3-yl) maleimide (DACM) to produce a blue fluorescence compound. Acetylthiocholine 78-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 21376964-2 2011 Under the catalytic effect of acetylcholinesterase (AChE), acetylthiocholine (ATCh) hydrolysis released thiocholine (TCh) which could react with N-(7-dimethylamino-4-methylcoumarin-3-yl) maleimide (DACM) to produce a blue fluorescence compound. Thiocholine 65-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 21376964-2 2011 Under the catalytic effect of acetylcholinesterase (AChE), acetylthiocholine (ATCh) hydrolysis released thiocholine (TCh) which could react with N-(7-dimethylamino-4-methylcoumarin-3-yl) maleimide (DACM) to produce a blue fluorescence compound. Thiocholine 65-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 21376964-2 2011 Under the catalytic effect of acetylcholinesterase (AChE), acetylthiocholine (ATCh) hydrolysis released thiocholine (TCh) which could react with N-(7-dimethylamino-4-methylcoumarin-3-yl) maleimide (DACM) to produce a blue fluorescence compound. Thiocholine 79-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 21376964-2 2011 Under the catalytic effect of acetylcholinesterase (AChE), acetylthiocholine (ATCh) hydrolysis released thiocholine (TCh) which could react with N-(7-dimethylamino-4-methylcoumarin-3-yl) maleimide (DACM) to produce a blue fluorescence compound. Thiocholine 79-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 21376964-2 2011 Under the catalytic effect of acetylcholinesterase (AChE), acetylthiocholine (ATCh) hydrolysis released thiocholine (TCh) which could react with N-(7-dimethylamino-4-methylcoumarin-3-yl) maleimide (DACM) to produce a blue fluorescence compound. N-(7-dimethylamino-4-methylcoumarinyl)maleimide 145-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 21376964-2 2011 Under the catalytic effect of acetylcholinesterase (AChE), acetylthiocholine (ATCh) hydrolysis released thiocholine (TCh) which could react with N-(7-dimethylamino-4-methylcoumarin-3-yl) maleimide (DACM) to produce a blue fluorescence compound. N-(7-dimethylamino-4-methylcoumarinyl)maleimide 145-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 21376964-2 2011 Under the catalytic effect of acetylcholinesterase (AChE), acetylthiocholine (ATCh) hydrolysis released thiocholine (TCh) which could react with N-(7-dimethylamino-4-methylcoumarin-3-yl) maleimide (DACM) to produce a blue fluorescence compound. N-(7-dimethylamino-4-methylcoumarinyl)maleimide 198-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 21376964-2 2011 Under the catalytic effect of acetylcholinesterase (AChE), acetylthiocholine (ATCh) hydrolysis released thiocholine (TCh) which could react with N-(7-dimethylamino-4-methylcoumarin-3-yl) maleimide (DACM) to produce a blue fluorescence compound. N-(7-dimethylamino-4-methylcoumarinyl)maleimide 198-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 21376964-3 2011 Subsequently, AChE catalytic activity was inhibited with the addition of paraoxon, which caused TCh decreased, leading to a significant decrease of the blue fluorescent compound. Paraoxon 73-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 21376964-3 2011 Subsequently, AChE catalytic activity was inhibited with the addition of paraoxon, which caused TCh decreased, leading to a significant decrease of the blue fluorescent compound. Thiocholine 96-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 21438627-0 2011 Colorimetric assays for acetylcholinesterase activity and inhibitor screening based on the disassembly-assembly of a water-soluble polythiophene derivative. Water 117-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 21438627-0 2011 Colorimetric assays for acetylcholinesterase activity and inhibitor screening based on the disassembly-assembly of a water-soluble polythiophene derivative. polythiophene 131-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 21438627-3 2011 It was confirmed that the introduction of myristoylcholine into PT-COO(-) phosphate buffer solution resulted in the disassembly of PT-COO(-) aggregates, and further addition of AChE into the above solution led to the reassembly of PT-COO(-) due to the catalyzed hydrolysis of myristoylcholine and the collapse of the complex. myristoylcholine 276-292 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-181 21438627-1 2011 A complex between an anionic polythiophene derivative (PT-COO(-)) and a cationic surfactant, myristoylcholine, has been prepared and applied to be colorimetric probe for acetylcholinesterase (AChE) assays. polythiophene 29-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-190 21438627-1 2011 A complex between an anionic polythiophene derivative (PT-COO(-)) and a cationic surfactant, myristoylcholine, has been prepared and applied to be colorimetric probe for acetylcholinesterase (AChE) assays. polythiophene 29-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 21438627-1 2011 A complex between an anionic polythiophene derivative (PT-COO(-)) and a cationic surfactant, myristoylcholine, has been prepared and applied to be colorimetric probe for acetylcholinesterase (AChE) assays. pt-coo(-) 55-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-190 21438627-1 2011 A complex between an anionic polythiophene derivative (PT-COO(-)) and a cationic surfactant, myristoylcholine, has been prepared and applied to be colorimetric probe for acetylcholinesterase (AChE) assays. pt-coo(-) 55-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 21438627-1 2011 A complex between an anionic polythiophene derivative (PT-COO(-)) and a cationic surfactant, myristoylcholine, has been prepared and applied to be colorimetric probe for acetylcholinesterase (AChE) assays. myristoylcholine 93-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-190 21438627-1 2011 A complex between an anionic polythiophene derivative (PT-COO(-)) and a cationic surfactant, myristoylcholine, has been prepared and applied to be colorimetric probe for acetylcholinesterase (AChE) assays. myristoylcholine 93-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 21397508-0 2011 Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and beta-amyloid aggregation inhibitors. Triazoles 65-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 21594999-4 2011 Treatment with the NChR allosteric modulator and acetylcholinesterase (AChE) inhibitor, galantamine, led to a dramatic decline in the frequency and intensity of rage outbursts, suggesting that enhancement of alpha7 NChR function can ameliorate 15q13.3DS-associated rage outbursts. Galantamine 88-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 21594999-4 2011 Treatment with the NChR allosteric modulator and acetylcholinesterase (AChE) inhibitor, galantamine, led to a dramatic decline in the frequency and intensity of rage outbursts, suggesting that enhancement of alpha7 NChR function can ameliorate 15q13.3DS-associated rage outbursts. Galantamine 88-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 21397508-0 2011 Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and beta-amyloid aggregation inhibitors. Berberine 85-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 21429752-2 2011 In vitro screening identified N-(naphth-1-ylmethyl)-2-(pyrrolidin-1-yl)pyrimidin-4-amine (9a) as the most potent AChE inhibitor (IC(50)=5.5 muM). n-(naphth-1-ylmethyl)-2-(pyrrolidin-1-yl)pyrimidin-4-amine 30-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 21397508-3 2011 Among them, compound 16d, which featured a diisopropylamino substitution at the 4-position of triazole ring, was found to be a potent inhibitor of AChE, with IC(50) value of 0.044 muM. diisopropylamino 43-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 21429752-4 2011 In addition, the selective AChE inhibitor N-benzyl-2-(4-methylpiperazin-1-yl)pyrimidin-4-amine (7d), exhibited good inhibition of hAChE-induced aggregation of Abeta(1-40) fibrils (59% inhibition). CHEMBL1084808 42-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 21397508-3 2011 Among them, compound 16d, which featured a diisopropylamino substitution at the 4-position of triazole ring, was found to be a potent inhibitor of AChE, with IC(50) value of 0.044 muM. Triazoles 94-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 21429752-5 2011 Furthermore, molecular modeling studies indicate that a central pyrimidine ring serves as a suitable template to develop dual inhibitors of cholinesterase and AChE-induced Abeta aggregation thereby targeting multiple pathological routes in AD. pyrimidine 64-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 21397508-5 2011 Molecular modeling studies indicated that the triazole moiety of berberine derivatives displayed a face-to-face pi-pi stacking interaction in a "sandwich" form with the Trp84 (4.09 A) and Phe330 (4.33 A) in catalytic sites of AChE. Triazoles 46-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-230 21397508-5 2011 Molecular modeling studies indicated that the triazole moiety of berberine derivatives displayed a face-to-face pi-pi stacking interaction in a "sandwich" form with the Trp84 (4.09 A) and Phe330 (4.33 A) in catalytic sites of AChE. Berberine 65-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-230 21772691-4 2011 After ruling out other causes of resistance to non-depolarizing muscle relaxants, we concluded that acetylcholinesterase inhibitor donepezil was primarily responsible for inadequate muscle relaxation and delayed post-operative neuromuscular recovery. Donepezil 131-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 24800340-0 2011 Effect of doxorubicin and daunorubicin on the activity of acetylcholinesterase in acute lymphoblastic leukamia. Doxorubicin 10-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 24800340-0 2011 Effect of doxorubicin and daunorubicin on the activity of acetylcholinesterase in acute lymphoblastic leukamia. Daunorubicin 26-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 20669006-1 2011 Acetylcholinesterase (AChE) is the primary target of organophosphorus compounds (OP). Organophosphorus Compounds 53-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21377346-0 2011 A novel, sensitive, reusable and low potential acetylcholinesterase biosensor for chlorpyrifos based on 1-butyl-3-methylimidazolium tetrafluoroborate/multiwalled carbon nanotubes gel. Chlorpyrifos 82-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 21377346-0 2011 A novel, sensitive, reusable and low potential acetylcholinesterase biosensor for chlorpyrifos based on 1-butyl-3-methylimidazolium tetrafluoroborate/multiwalled carbon nanotubes gel. 1-butyl-3-methylimidazolium tetrafluoroborate 104-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 21377346-0 2011 A novel, sensitive, reusable and low potential acetylcholinesterase biosensor for chlorpyrifos based on 1-butyl-3-methylimidazolium tetrafluoroborate/multiwalled carbon nanotubes gel. Carbon 162-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 21377346-1 2011 A novel, low potential and highly sensitive acetylcholinesterase (AChE) biosensor was developed based on 1-butyl-3-methylimidazolium tetrafluoroborate/multiwalled carbon nanotube composite gel thiocholine sensor. 1-butyl-3-methylimidazolium tetrafluoroborate 105-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 21377346-1 2011 A novel, low potential and highly sensitive acetylcholinesterase (AChE) biosensor was developed based on 1-butyl-3-methylimidazolium tetrafluoroborate/multiwalled carbon nanotube composite gel thiocholine sensor. 1-butyl-3-methylimidazolium tetrafluoroborate 105-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 21377346-1 2011 A novel, low potential and highly sensitive acetylcholinesterase (AChE) biosensor was developed based on 1-butyl-3-methylimidazolium tetrafluoroborate/multiwalled carbon nanotube composite gel thiocholine sensor. Carbon 163-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 21377346-1 2011 A novel, low potential and highly sensitive acetylcholinesterase (AChE) biosensor was developed based on 1-butyl-3-methylimidazolium tetrafluoroborate/multiwalled carbon nanotube composite gel thiocholine sensor. Carbon 163-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 21377346-1 2011 A novel, low potential and highly sensitive acetylcholinesterase (AChE) biosensor was developed based on 1-butyl-3-methylimidazolium tetrafluoroborate/multiwalled carbon nanotube composite gel thiocholine sensor. Thiocholine 193-204 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 21377346-1 2011 A novel, low potential and highly sensitive acetylcholinesterase (AChE) biosensor was developed based on 1-butyl-3-methylimidazolium tetrafluoroborate/multiwalled carbon nanotube composite gel thiocholine sensor. Thiocholine 193-204 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 21381712-1 2011 Acetylcholinesterase inhibitor (-)-homogalanthamine 3 was synthesized from mu opioid antagonist naltrexone (2) in 16% total yield. (-)-homogalanthamine 3 31-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21381712-1 2011 Acetylcholinesterase inhibitor (-)-homogalanthamine 3 was synthesized from mu opioid antagonist naltrexone (2) in 16% total yield. Naltrexone 96-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21404290-0 2011 Protection of human muscle acetylcholinesterase from soman by pyridostigmine bromide. Pyridostigmine Bromide 62-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 21404290-1 2011 INTRODUCTION: Pretreatment with pyridostigmine bromide (PB) of human intercostal muscle fibers exposed to the irreversible acetylcholinesterase (AChE) inhibitor soman was investigated. Pyridostigmine Bromide 56-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 21404290-4 2011 In contrast, PB pretreatment of soman-exposed bundles protected 20% of AChE activity. Pyridostigmine Bromide 13-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 21404290-5 2011 AChE of bundles exposed to PB alone recovered after 4 hours, but bundles exposed to both PB and soman did not. Pyridostigmine Bromide 27-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 21404290-7 2011 CONCLUSIONS: In vitro pretreatment of human muscles with PB protected up to 20% of muscle AChE and ameliorated some deleterious effects on endplate physiology induced by soman. Pyridostigmine Bromide 57-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 20669006-1 2011 Acetylcholinesterase (AChE) is the primary target of organophosphorus compounds (OP). Organophosphorus Compounds 53-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 20669006-4 2011 Compared to phosphate buffer, the inhibition and reactivation kinetics of human erythrocyte AChE were markedly changed by TRIS and in part by MOPS, whereas Tyrode showed similar results to phosphate buffer. Phosphates 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 20669006-4 2011 Compared to phosphate buffer, the inhibition and reactivation kinetics of human erythrocyte AChE were markedly changed by TRIS and in part by MOPS, whereas Tyrode showed similar results to phosphate buffer. Tromethamine 122-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 20669006-4 2011 Compared to phosphate buffer, the inhibition and reactivation kinetics of human erythrocyte AChE were markedly changed by TRIS and in part by MOPS, whereas Tyrode showed similar results to phosphate buffer. Phosphates 189-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 20669006-6 2011 In view of the comparability of human in vitro kinetic data determined with phosphate buffer with data from human OP poisoning, it seems to be a suitable buffer for the investigation into interactions between AChE, OP and oximes. Phosphates 76-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-213 21239059-7 2011 Levels of Cd and Cr were associated with the inhibition of AChE and with the enhancement of GST. Cadmium 10-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 21239059-7 2011 Levels of Cd and Cr were associated with the inhibition of AChE and with the enhancement of GST. Chromium 17-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 21298709-1 2011 Organophosphorus pesticide (OPP) toxicity is believed to be mediated through inhibition of acetylcholinesterase (AChE). organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 21298709-1 2011 Organophosphorus pesticide (OPP) toxicity is believed to be mediated through inhibition of acetylcholinesterase (AChE). organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 21298709-1 2011 Organophosphorus pesticide (OPP) toxicity is believed to be mediated through inhibition of acetylcholinesterase (AChE). opp 28-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 21298709-1 2011 Organophosphorus pesticide (OPP) toxicity is believed to be mediated through inhibition of acetylcholinesterase (AChE). opp 28-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 21328273-2 2011 Standard treatment involves administration of intravenous atropine and oxime to reactivate inhibited acetylcholinesterase. Oximes 71-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 21851044-1 2011 The influence of cationic detergent cetyltrimethylammonium on the human blood cholinesterases activity (erythrocyte acetylcholinesterase and plasma butyrylcholinesterase) in reactions of hydrolysis of alpha-thionaphthylacetat and acetylthiocholine is studied. Cetrimonium 36-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 21851044-1 2011 The influence of cationic detergent cetyltrimethylammonium on the human blood cholinesterases activity (erythrocyte acetylcholinesterase and plasma butyrylcholinesterase) in reactions of hydrolysis of alpha-thionaphthylacetat and acetylthiocholine is studied. alpha-thionaphthylacetat 201-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 21851044-3 2011 This compound competitively inhibited enzymatic hydrolysis of acetylthiocholine by both cholinesterases, and in the reactions of enzymatic hydrolysis alpha-thionaphthylacetat display as the synergistic activator--in experiments with butyrylcholinesterase, and as the reversible inhibitor--in experiments with acetylcholinesterase. alpha-thionaphthylacetat 150-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 309-329 21851044-4 2011 Kinetic constants in reaction of acetylcholinesterase inhibition by cetyltrimethylammonium defined by means of different substrates--alpha-thionaphthylacetat and acetylthiocholin. Cetrimonium 68-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 21851044-4 2011 Kinetic constants in reaction of acetylcholinesterase inhibition by cetyltrimethylammonium defined by means of different substrates--alpha-thionaphthylacetat and acetylthiocholin. alpha-thionaphthylacetat 133-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 21851044-4 2011 Kinetic constants in reaction of acetylcholinesterase inhibition by cetyltrimethylammonium defined by means of different substrates--alpha-thionaphthylacetat and acetylthiocholin. acetylthiocholin 162-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 21352527-1 2011 INTRODUCTION: Neostigmine is a frequently used acetylcholinesterase inhibitor administered to reverse muscular relaxation caused by nondepolarizing neuromuscular relaxants in patients recovering from general anesthesia. Neostigmine 14-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 21152577-0 2011 Clicked tacrine conjugates as acetylcholinesterase and beta-amyloid directed compounds. Tacrine 8-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 21152577-1 2011 The multifaceted nature of Alzheimer"s disease (AD) has led to the development of multi-targeted compounds based on the classical AD drug, tacrine, first known to inhibit the acetylcholine-degrading enzyme acetylcholinesterase (AChE). Tacrine 139-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 206-226 21152577-1 2011 The multifaceted nature of Alzheimer"s disease (AD) has led to the development of multi-targeted compounds based on the classical AD drug, tacrine, first known to inhibit the acetylcholine-degrading enzyme acetylcholinesterase (AChE). Tacrine 139-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 228-232 21152577-1 2011 The multifaceted nature of Alzheimer"s disease (AD) has led to the development of multi-targeted compounds based on the classical AD drug, tacrine, first known to inhibit the acetylcholine-degrading enzyme acetylcholinesterase (AChE). Acetylcholine 175-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 206-226 21152577-1 2011 The multifaceted nature of Alzheimer"s disease (AD) has led to the development of multi-targeted compounds based on the classical AD drug, tacrine, first known to inhibit the acetylcholine-degrading enzyme acetylcholinesterase (AChE). Acetylcholine 175-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 228-232 21152577-6 2011 Moreover, they have the capacity to bind to Abeta(40) fibrils (SPR assays) while retaining the AChE inhibitory activity of the parent tacrine. Tacrine 134-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 21343890-1 2011 A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazole with beta-ketoesters using tin(IV) chloride as catalyst. Tacrine 76-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 21343890-1 2011 A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazole with beta-ketoesters using tin(IV) chloride as catalyst. Tacrine 76-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 21343890-1 2011 A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazole with beta-ketoesters using tin(IV) chloride as catalyst. tramiprosate 94-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 21343890-1 2011 A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazole with beta-ketoesters using tin(IV) chloride as catalyst. tramiprosate 94-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 21343890-1 2011 A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazole with beta-ketoesters using tin(IV) chloride as catalyst. 1-aryl-4-cyano-5-aminopyrazole 153-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 21343890-1 2011 A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazole with beta-ketoesters using tin(IV) chloride as catalyst. 1-aryl-4-cyano-5-aminopyrazole 153-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 21343890-1 2011 A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazole with beta-ketoesters using tin(IV) chloride as catalyst. stannic chloride 211-227 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 21343890-1 2011 A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazole with beta-ketoesters using tin(IV) chloride as catalyst. stannic chloride 211-227 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 21152493-1 2011 A novel and versatile processing method was developed for the formation of gel scaffolds with in situ AChE-AuNPs immobilization for biosensing of organophosphorus compounds. organophosphorus 146-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 21196108-0 2011 Highly-sensitive organophosphorous pesticide biosensors based on nanostructured films of acetylcholinesterase and CdTe quantum dots. organophosphorous 17-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 21196108-1 2011 The optical transducer of CdTe semiconductor quantum dots (QDs) has been integrated with acetylcholinesterase enzyme (AChE) by the layer-by-layer (LbL) assembly technique, resulting in a highly sensitive biosensor for detection of organophosphorus pesticides (OPs) in vegetables and fruits based on enzyme inhibition mechanism. cadmium telluride 26-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-116 21196108-1 2011 The optical transducer of CdTe semiconductor quantum dots (QDs) has been integrated with acetylcholinesterase enzyme (AChE) by the layer-by-layer (LbL) assembly technique, resulting in a highly sensitive biosensor for detection of organophosphorus pesticides (OPs) in vegetables and fruits based on enzyme inhibition mechanism. cadmium telluride 26-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 21196108-1 2011 The optical transducer of CdTe semiconductor quantum dots (QDs) has been integrated with acetylcholinesterase enzyme (AChE) by the layer-by-layer (LbL) assembly technique, resulting in a highly sensitive biosensor for detection of organophosphorus pesticides (OPs) in vegetables and fruits based on enzyme inhibition mechanism. organophosphorus 231-247 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-116 21196108-1 2011 The optical transducer of CdTe semiconductor quantum dots (QDs) has been integrated with acetylcholinesterase enzyme (AChE) by the layer-by-layer (LbL) assembly technique, resulting in a highly sensitive biosensor for detection of organophosphorus pesticides (OPs) in vegetables and fruits based on enzyme inhibition mechanism. organophosphorus 231-247 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 21175195-4 2011 Notably, despite the fact that acetylcholinesterase (AChE) and BChE are very similar enzymes, the acylation of BChE with ACh is rate-determining, which is remarkably different from the AChE-catalyzed hydrolysis of ACh, in which the deacylation is rate-determining. Acetylcholine 53-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 21175195-4 2011 Notably, despite the fact that acetylcholinesterase (AChE) and BChE are very similar enzymes, the acylation of BChE with ACh is rate-determining, which is remarkably different from the AChE-catalyzed hydrolysis of ACh, in which the deacylation is rate-determining. Acetylcholine 121-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 21175195-4 2011 Notably, despite the fact that acetylcholinesterase (AChE) and BChE are very similar enzymes, the acylation of BChE with ACh is rate-determining, which is remarkably different from the AChE-catalyzed hydrolysis of ACh, in which the deacylation is rate-determining. Acetylcholine 121-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 21299848-4 2011 Symptomatic treatments for moderate to severe Alzheimer"s disease are approved in the United States and include the acetylcholinesterase inhibitor donepezil and the glutamate receptor antagonist memantine. Donepezil 147-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 21217689-6 2011 We also developed a direct screen for protection of acetylcholinesterase from inactivation by nerve agents and used it to isolate variants that degrade the toxic isomer of the coumarin analog and cyclosarin itself with k(cat)/K(M) ~ 10(7) M(-1) min(-1). coumarin 176-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 21274871-5 2011 Further study showed that ACHE suppressed cell proliferation via its enzymatic activity of acetylcholine catalysis and degradation. Acetylcholine 91-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 21274871-7 2011 In addition, increased ACHE expression could remarkably sensitize HCC cells to chemotherapeutic drugs (i.e., adriamycin and etoposide). Doxorubicin 109-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 21274871-7 2011 In addition, increased ACHE expression could remarkably sensitize HCC cells to chemotherapeutic drugs (i.e., adriamycin and etoposide). Etoposide 124-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 20851778-1 2011 UNLABELLED: Binding energy calculations of huperzine A (HUP A) and galanthamine (GAL) to the binding pocket of the acetylcholinesterase enzyme (AChE) were studied. huperzine A 43-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-142 20851778-1 2011 UNLABELLED: Binding energy calculations of huperzine A (HUP A) and galanthamine (GAL) to the binding pocket of the acetylcholinesterase enzyme (AChE) were studied. huperzine A 43-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 20851778-1 2011 UNLABELLED: Binding energy calculations of huperzine A (HUP A) and galanthamine (GAL) to the binding pocket of the acetylcholinesterase enzyme (AChE) were studied. Huperzine A 56-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-142 21217689-6 2011 We also developed a direct screen for protection of acetylcholinesterase from inactivation by nerve agents and used it to isolate variants that degrade the toxic isomer of the coumarin analog and cyclosarin itself with k(cat)/K(M) ~ 10(7) M(-1) min(-1). cyclohexyl methylphosphonofluoridate 196-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 20851778-1 2011 UNLABELLED: Binding energy calculations of huperzine A (HUP A) and galanthamine (GAL) to the binding pocket of the acetylcholinesterase enzyme (AChE) were studied. Huperzine A 56-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 20851778-1 2011 UNLABELLED: Binding energy calculations of huperzine A (HUP A) and galanthamine (GAL) to the binding pocket of the acetylcholinesterase enzyme (AChE) were studied. Galantamine 67-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-142 20851778-1 2011 UNLABELLED: Binding energy calculations of huperzine A (HUP A) and galanthamine (GAL) to the binding pocket of the acetylcholinesterase enzyme (AChE) were studied. Galantamine 67-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 20851778-1 2011 UNLABELLED: Binding energy calculations of huperzine A (HUP A) and galanthamine (GAL) to the binding pocket of the acetylcholinesterase enzyme (AChE) were studied. Galantamine 81-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-142 20851778-1 2011 UNLABELLED: Binding energy calculations of huperzine A (HUP A) and galanthamine (GAL) to the binding pocket of the acetylcholinesterase enzyme (AChE) were studied. Galantamine 81-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 21425688-1 2011 This study aimed to investigate for the first time the chemical composition, the antioxidant properties and the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity of the essential oil from the leaves of Cordia gilletii De Wild (Boraginaceae). Oils, Volatile 200-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 21425688-1 2011 This study aimed to investigate for the first time the chemical composition, the antioxidant properties and the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity of the essential oil from the leaves of Cordia gilletii De Wild (Boraginaceae). Oils, Volatile 200-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 20641061-1 2011 Corynoline, an isoquinoline alkaloid isolated from the genus Corydalis, has been demonstrated to show multiple pharmacological effects including inhibition of acetylcholinesterase, inhibition of cell adhesion, fungitoxic and cytotoxic activity. corynoline 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 20688148-0 2011 In vitro reactivation of sarin-inhibited human acetylcholinesterase (AChE) by bis-pyridinium oximes connected by xylene linkers. bis-pyridinium oximes 78-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 20688148-0 2011 In vitro reactivation of sarin-inhibited human acetylcholinesterase (AChE) by bis-pyridinium oximes connected by xylene linkers. Xylenes 113-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 20888407-1 2011 Although organophosphate (OP)-induced acetylcholinesterase (AChE) inhibition is the critical mechanism causing toxicities that follow exposure, other biochemical events, including oxidative stress, have been reported to contribute to OP toxicity. Organophosphates 9-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 20688148-1 2011 A series of bis-pyridinium oximes connected by xylene linkers were synthesized and their in vitro reactivation potential was evaluated against human acetylcholinesterase (hAChE) inhibited by nerve agent sarin and the data were compared with 2-PAM and obidoxime. bis-pyridinium oximes 12-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-176 20888407-5 2011 Activities of brain and SH-SY5Y AChE with OP compounds alone ranged from 55-83% lower than non-treated controls after paraoxon and from 60-92% lower than non-treated controls after DFP. Paraoxon 118-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 20688148-2 2011 Among the synthesized compounds, N,N"-p-xylene-bis-[(2,2"-hydroxyiminomethyl)pyridinium] dibromide (3c) was found to be the most potent reactivator for hAChE inhibited by sarin. N,N'-p-xylene-bis-((2,2'-hydroxyiminomethyl)pyridinium) dibromide 33-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-157 20888407-6 2011 Most incubations containing 1 and 10 muM fullerene derivatives brought AChE activity closer to untreated controls, with improvements in AChE activity often >20%. Fullerenes 41-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 20888407-6 2011 Most incubations containing 1 and 10 muM fullerene derivatives brought AChE activity closer to untreated controls, with improvements in AChE activity often >20%. Fullerenes 41-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 20888407-9 2011 These studies suggest that derivatized fullerene nanomaterials have potential capability to ameliorate OP-induced AChE inhibition resulting in toxicities. Fullerenes 39-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 20688148-3 2011 The oxime 3c exhibited 45% regeneration of inhibited hAChE, in comparison to 34% and 24% regeneration by 2-PAM and obidoxime, respectively, at a concentration of 10(-3) M within 10 min. Oximes 4-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-58 20688148-6 2011 This method involving the in vitro reactivation of inhibited hAChE may be useful for the screening of new oximes as reactivators. Oximes 106-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-66 21215642-5 2011 These compounds were synthesized, evaluated in vitro on human AChE (hAChE) inhibited by tabun, paraoxon, methylparaoxon and DFP and then compared to commercial hAChE reactivators (pralidoxime, HI-6, trimedoxime, obidoxime, methoxime) or previously prepared compounds (K027, K203). Paraoxon 95-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 21168544-2 2011 The capability of IMS in the determination of enzyme kinetics and inhibition studies by the analysis of substrate depletion and/or product formation using only a few microliters of solution has been successfully demonstrated on the example of acetylcholine hydrolysis catalyzed by acetylcholinesterase (AChE) and inhibited by neostigmine and galanthamine. Acetylcholine 243-256 acetylcholinesterase (Cartwright blood group) Homo sapiens 281-301 21168544-2 2011 The capability of IMS in the determination of enzyme kinetics and inhibition studies by the analysis of substrate depletion and/or product formation using only a few microliters of solution has been successfully demonstrated on the example of acetylcholine hydrolysis catalyzed by acetylcholinesterase (AChE) and inhibited by neostigmine and galanthamine. Acetylcholine 243-256 acetylcholinesterase (Cartwright blood group) Homo sapiens 303-307 21168544-2 2011 The capability of IMS in the determination of enzyme kinetics and inhibition studies by the analysis of substrate depletion and/or product formation using only a few microliters of solution has been successfully demonstrated on the example of acetylcholine hydrolysis catalyzed by acetylcholinesterase (AChE) and inhibited by neostigmine and galanthamine. Neostigmine 326-337 acetylcholinesterase (Cartwright blood group) Homo sapiens 281-301 21168544-2 2011 The capability of IMS in the determination of enzyme kinetics and inhibition studies by the analysis of substrate depletion and/or product formation using only a few microliters of solution has been successfully demonstrated on the example of acetylcholine hydrolysis catalyzed by acetylcholinesterase (AChE) and inhibited by neostigmine and galanthamine. Neostigmine 326-337 acetylcholinesterase (Cartwright blood group) Homo sapiens 303-307 21168544-2 2011 The capability of IMS in the determination of enzyme kinetics and inhibition studies by the analysis of substrate depletion and/or product formation using only a few microliters of solution has been successfully demonstrated on the example of acetylcholine hydrolysis catalyzed by acetylcholinesterase (AChE) and inhibited by neostigmine and galanthamine. Galantamine 342-354 acetylcholinesterase (Cartwright blood group) Homo sapiens 281-301 21168544-2 2011 The capability of IMS in the determination of enzyme kinetics and inhibition studies by the analysis of substrate depletion and/or product formation using only a few microliters of solution has been successfully demonstrated on the example of acetylcholine hydrolysis catalyzed by acetylcholinesterase (AChE) and inhibited by neostigmine and galanthamine. Galantamine 342-354 acetylcholinesterase (Cartwright blood group) Homo sapiens 303-307 20849808-4 2011 AChE was immobilized on the gold surface of an SPR sensor through covalent attachment to a self-assembled monolayer (SAM) of a COOH-terminated alkanethiol. Carbonic Acid 127-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 20849808-4 2011 AChE was immobilized on the gold surface of an SPR sensor through covalent attachment to a self-assembled monolayer (SAM) of a COOH-terminated alkanethiol. alkanethiol 143-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 21211982-2 2011 All the synthesized compounds had high acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activity with IC50 values at the nanomolar range, which were much better than tacrine alone. Tacrine 190-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 21211982-3 2011 A Lineweaver-Burk plot and molecular modeling study showed that these hybrids targeted both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. cas 119-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 21211982-3 2011 A Lineweaver-Burk plot and molecular modeling study showed that these hybrids targeted both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. Aminosalicylic Acid 157-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 21215642-0 2011 Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage-Preparation, in vitro screening and molecular docking. mono-oxime 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 21215642-5 2011 These compounds were synthesized, evaluated in vitro on human AChE (hAChE) inhibited by tabun, paraoxon, methylparaoxon and DFP and then compared to commercial hAChE reactivators (pralidoxime, HI-6, trimedoxime, obidoxime, methoxime) or previously prepared compounds (K027, K203). Paraoxon 95-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-73 21215642-1 2011 The treatment of organophosphorus (OP) poisoning consists of the administration of a parasympatholytic agent (e.g., atropine), an anticonvulsant (e.g., diazepam) and an acetylcholinesterase (AChE) reactivator (e.g., obidoxime). organophosphorus 17-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-189 21215642-1 2011 The treatment of organophosphorus (OP) poisoning consists of the administration of a parasympatholytic agent (e.g., atropine), an anticonvulsant (e.g., diazepam) and an acetylcholinesterase (AChE) reactivator (e.g., obidoxime). organophosphorus 17-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 191-195 21215642-5 2011 These compounds were synthesized, evaluated in vitro on human AChE (hAChE) inhibited by tabun, paraoxon, methylparaoxon and DFP and then compared to commercial hAChE reactivators (pralidoxime, HI-6, trimedoxime, obidoxime, methoxime) or previously prepared compounds (K027, K203). methylparaoxon 105-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 21215642-5 2011 These compounds were synthesized, evaluated in vitro on human AChE (hAChE) inhibited by tabun, paraoxon, methylparaoxon and DFP and then compared to commercial hAChE reactivators (pralidoxime, HI-6, trimedoxime, obidoxime, methoxime) or previously prepared compounds (K027, K203). methylparaoxon 105-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-73 21215642-5 2011 These compounds were synthesized, evaluated in vitro on human AChE (hAChE) inhibited by tabun, paraoxon, methylparaoxon and DFP and then compared to commercial hAChE reactivators (pralidoxime, HI-6, trimedoxime, obidoxime, methoxime) or previously prepared compounds (K027, K203). Isoflurophate 124-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 21215642-5 2011 These compounds were synthesized, evaluated in vitro on human AChE (hAChE) inhibited by tabun, paraoxon, methylparaoxon and DFP and then compared to commercial hAChE reactivators (pralidoxime, HI-6, trimedoxime, obidoxime, methoxime) or previously prepared compounds (K027, K203). Isoflurophate 124-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-73 21215642-8 2011 The docking results confirmed the apparent influence of pi-pi or cation-pi interactions and hydrogen bonding for reactivator binding within the hAChE active site cleft. Hydrogen 92-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-149 22238531-6 2011 Among the nine compounds investigated, one exhibited remarkable activity, completely preventing acetylcholinesterase inhibition by the (-)-enantiomer of cyclosarin within seconds under the conditions of the assay. cyclohexyl methylphosphonofluoridate 153-163 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 20971170-1 2011 Previous in vitro studies showed marked species differences in the reactivating efficiency of oximes between human and animal acetylcholinesterase (AChE) inhibited by organophosphorus (OP) nerve agents. Oximes 94-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 20971170-1 2011 Previous in vitro studies showed marked species differences in the reactivating efficiency of oximes between human and animal acetylcholinesterase (AChE) inhibited by organophosphorus (OP) nerve agents. Oximes 94-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 20971170-1 2011 Previous in vitro studies showed marked species differences in the reactivating efficiency of oximes between human and animal acetylcholinesterase (AChE) inhibited by organophosphorus (OP) nerve agents. organophosphorus 167-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 20971170-1 2011 Previous in vitro studies showed marked species differences in the reactivating efficiency of oximes between human and animal acetylcholinesterase (AChE) inhibited by organophosphorus (OP) nerve agents. organophosphorus 167-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 20927440-1 2011 A resorufin derivative with a DBS group (probe 1) was designed and investigated for the detection of acetylcholinesterase (AChE) and inhibitor screening. resorufin 2-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 20927440-1 2011 A resorufin derivative with a DBS group (probe 1) was designed and investigated for the detection of acetylcholinesterase (AChE) and inhibitor screening. resorufin 2-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 21666889-1 2011 A conjugate of pyridine-4-aldoxime and atropine (ATR-4-OX) was synthesized and its antidotal efficiency was tested in vitro on tabun- or paraoxon-inhibited acetylcholinesterase (AChE) of human erythrocytes as well as in vivo using soman-, tabun- or paraoxon-poisoned mice. pyridine-4-aldoxime 15-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-182 21666889-1 2011 A conjugate of pyridine-4-aldoxime and atropine (ATR-4-OX) was synthesized and its antidotal efficiency was tested in vitro on tabun- or paraoxon-inhibited acetylcholinesterase (AChE) of human erythrocytes as well as in vivo using soman-, tabun- or paraoxon-poisoned mice. Atropine 39-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-182 21666889-1 2011 A conjugate of pyridine-4-aldoxime and atropine (ATR-4-OX) was synthesized and its antidotal efficiency was tested in vitro on tabun- or paraoxon-inhibited acetylcholinesterase (AChE) of human erythrocytes as well as in vivo using soman-, tabun- or paraoxon-poisoned mice. 8-(4-(4-(-(hydroxyimino)methyl)-1-pyridiniumyl)butyl)-3-((3-hydroxy-2-phenylpropanoyl)oxy)-8-methyl-8-azoniabicyclo(3.2.1)octane 49-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-182 21666889-7 2011 It appears that ATR-4-OX has a therapeutic effect related to the reactivation of phosphylated AChE, but not to receptor antagonization. 8-(4-(4-(-(hydroxyimino)methyl)-1-pyridiniumyl)butyl)-3-((3-hydroxy-2-phenylpropanoyl)oxy)-8-methyl-8-azoniabicyclo(3.2.1)octane 16-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 21355440-0 2011 Synthesis of novel 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(substituted/-nonsubstituted benzal)hydrazone derivatives and acetylcholinesterase and butyrylcholinesterase inhibitory activities in vitro. 6-substituted-3(2h)-pyridazinone-2-acetyl-2-(substituted/-nonsubstituted benzal)hydrazone 19-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 21355440-1 2011 In this study thirteen 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(substituted/nonsubstituted benzal)hydrazone V derivatives were synthesized as acetylcholinesterase and butyrylcholinesterase inhibitors. 6-substituted-3(2h)-pyridazinone-2-acetyl-2-(substituted/nonsubstituted benzal)hydrazone v 23-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-166 21355440-5 2011 While some of the 6-substituted-3(2H)-pyridazinone-2-propyl-3-(substituted/-nonsubstituted benzal)hydrazone V derivatives exhibited significant AChE inhibitory activity, none of the compoundsshowed BChE inhibitory activity. 6-substituted-3(2h)-pyridazinone-2-propyl-3-(substituted/-nonsubstituted benzal)hydrazone v 18-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 21111617-0 2011 Silanetriols as in vitro inhibitors for AChE. silanetriols 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 21111617-2 2011 For all tested silanetriols we found reversible inhibition of the AChE activity at a 100 muM concentration. silanetriols 15-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 21112787-0 2011 Peripheral site ligand-oxime conjugates: A novel concept towards reactivation of nerve agent-inhibited human acetylcholinesterase. Oximes 23-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-129 21144749-2 2011 They work by blocking acetylcholinesterase"s (AChE) native function and thus protect AChE against irreversible inhibition by organophosphorus compounds. Organophosphorus Compounds 125-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-43 21144749-2 2011 They work by blocking acetylcholinesterase"s (AChE) native function and thus protect AChE against irreversible inhibition by organophosphorus compounds. Organophosphorus Compounds 125-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 21144749-2 2011 They work by blocking acetylcholinesterase"s (AChE) native function and thus protect AChE against irreversible inhibition by organophosphorus compounds. Organophosphorus Compounds 125-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 21144749-3 2011 However, carbamate inhibitors are known for many undesirable side-effects related to the carbamylation of AChE. Carbamates 9-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 21163662-5 2011 The biological evaluation showed that some of these molecules were good AChE inhibitors, in the nanomolar range, and quite selective regarding the inhibition of BuChE, the most potent being 5-amino-2-(dimethylamino)-6,7,8,9-tetrahydrobenzo[1,8-b]-naphthyridine-3-carbonitrile (11) [IC(50) (EeAChE: 14nM); IC(50) (eqBuChE: 5.2muM]. CHEMBL1644721 190-275 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 21516778-0 2011 [Molecular modeling of acetylcholinesterase interaction with irreversible and reversible organophosphorous inhibitors]. organophosphorous 89-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 22087826-0 2011 Flavonoids as acetylcholinesterase inhibitors. Flavonoids 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 22087826-3 2011 Flavonoids with AChE inhibitory activity and due to their well known antioxidant activity could be new multipotent drugs for AD treatment. Flavonoids 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 22087826-4 2011 This work focuses on natural and synthetic flavonoids inhibitors of the enzyme acetylcholinesterase (AChE). Flavonoids 43-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 22087826-4 2011 This work focuses on natural and synthetic flavonoids inhibitors of the enzyme acetylcholinesterase (AChE). Flavonoids 43-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 21291371-2 2011 ACh is a neurotransmitter hydrolyzed by acetylcholinesterase (AChE). Acetylcholine 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 21291371-2 2011 ACh is a neurotransmitter hydrolyzed by acetylcholinesterase (AChE). Acetylcholine 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 21787676-4 2011 Further, the paraoxon-induced modulatory effects were comparable despite different cell types, including over-expression of N-terminus acetylcholinesterase (N-AChE) protein, a marker of apoptosis, down-regulations of mRNA encoding M1, M2, and M3 muscarinic acetylcholine receptors (mAChRs), and induction in expression of c-Fos gene, an indication of certain mAChR subtype(s) activation. Paraoxon 13-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-155 21787676-4 2011 Further, the paraoxon-induced modulatory effects were comparable despite different cell types, including over-expression of N-terminus acetylcholinesterase (N-AChE) protein, a marker of apoptosis, down-regulations of mRNA encoding M1, M2, and M3 muscarinic acetylcholine receptors (mAChRs), and induction in expression of c-Fos gene, an indication of certain mAChR subtype(s) activation. Paraoxon 13-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-163 21787676-5 2011 Furthermore, the non-selective cholinergic antagonist atropine partially attenuated the paraoxon-induced N-AChE and c-Fos activations in both types of cells. Atropine 54-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-111 21787676-5 2011 Furthermore, the non-selective cholinergic antagonist atropine partially attenuated the paraoxon-induced N-AChE and c-Fos activations in both types of cells. Paraoxon 88-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-111 21074294-0 2011 Receptor-dependent (RD) 3D-QSAR approach of a series of benzylpiperidine inhibitors of human acetylcholinesterase (HuAChE). 1-benzylpiperidine 56-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 21074294-2 2011 In this work, we developed a receptor-dependent 3D-QSAR (RD-3D-QSAR) models based on a series of 60 benzylpiperidine inhibitors of human acetylcholinesterase to support the design of new AChEIs. 1-benzylpiperidine 100-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 21647289-0 2011 Evaluation of acetylcholinesterase biosensor based on carbon nanotube paste in the determination of chlorphenvinphos. Carbon 54-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 21647289-1 2011 An amperometric biosensor for chlorphenvinphos (organophosphorus pesticide) based on carbon nanotube paste and acetylcholinesterase enzyme (CNTs-AChE biosensor) is described herein. Chlorfenvinphos 30-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 21647289-1 2011 An amperometric biosensor for chlorphenvinphos (organophosphorus pesticide) based on carbon nanotube paste and acetylcholinesterase enzyme (CNTs-AChE biosensor) is described herein. Chlorfenvinphos 30-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 21647289-1 2011 An amperometric biosensor for chlorphenvinphos (organophosphorus pesticide) based on carbon nanotube paste and acetylcholinesterase enzyme (CNTs-AChE biosensor) is described herein. organophosphorus 48-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 21647289-1 2011 An amperometric biosensor for chlorphenvinphos (organophosphorus pesticide) based on carbon nanotube paste and acetylcholinesterase enzyme (CNTs-AChE biosensor) is described herein. organophosphorus 48-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 21673941-1 2011 We have in vitro tested the ability of common, commercially available, cholinesterase reactivators (pralidoxime, obidoxime, methoxime, trimedoxime and HI-6) to reactivate human acetylcholinesterase (AChE), inhibited by five structurally different organophosphate pesticides and inhibitors (paraoxon, dichlorvos, DFP, leptophos-oxon and methamidophos). Paraoxon 290-298 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-197 21673941-0 2011 In vitro ability of currently available oximes to reactivate organophosphate pesticide-inhibited human acetylcholinesterase and butyrylcholinesterase. Oximes 40-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 21673941-0 2011 In vitro ability of currently available oximes to reactivate organophosphate pesticide-inhibited human acetylcholinesterase and butyrylcholinesterase. Organophosphates 61-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 21673941-1 2011 We have in vitro tested the ability of common, commercially available, cholinesterase reactivators (pralidoxime, obidoxime, methoxime, trimedoxime and HI-6) to reactivate human acetylcholinesterase (AChE), inhibited by five structurally different organophosphate pesticides and inhibitors (paraoxon, dichlorvos, DFP, leptophos-oxon and methamidophos). pralidoxime 100-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-197 21673941-1 2011 We have in vitro tested the ability of common, commercially available, cholinesterase reactivators (pralidoxime, obidoxime, methoxime, trimedoxime and HI-6) to reactivate human acetylcholinesterase (AChE), inhibited by five structurally different organophosphate pesticides and inhibitors (paraoxon, dichlorvos, DFP, leptophos-oxon and methamidophos). Obidoxime Chloride 113-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-197 21673941-1 2011 We have in vitro tested the ability of common, commercially available, cholinesterase reactivators (pralidoxime, obidoxime, methoxime, trimedoxime and HI-6) to reactivate human acetylcholinesterase (AChE), inhibited by five structurally different organophosphate pesticides and inhibitors (paraoxon, dichlorvos, DFP, leptophos-oxon and methamidophos). N,N'-monomethylenebis(pyridiniumaldoxime) 124-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-197 21673941-1 2011 We have in vitro tested the ability of common, commercially available, cholinesterase reactivators (pralidoxime, obidoxime, methoxime, trimedoxime and HI-6) to reactivate human acetylcholinesterase (AChE), inhibited by five structurally different organophosphate pesticides and inhibitors (paraoxon, dichlorvos, DFP, leptophos-oxon and methamidophos). Trimedoxime 135-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-197 21673941-1 2011 We have in vitro tested the ability of common, commercially available, cholinesterase reactivators (pralidoxime, obidoxime, methoxime, trimedoxime and HI-6) to reactivate human acetylcholinesterase (AChE), inhibited by five structurally different organophosphate pesticides and inhibitors (paraoxon, dichlorvos, DFP, leptophos-oxon and methamidophos). asoxime chloride 151-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-197 21673941-1 2011 We have in vitro tested the ability of common, commercially available, cholinesterase reactivators (pralidoxime, obidoxime, methoxime, trimedoxime and HI-6) to reactivate human acetylcholinesterase (AChE), inhibited by five structurally different organophosphate pesticides and inhibitors (paraoxon, dichlorvos, DFP, leptophos-oxon and methamidophos). asoxime chloride 151-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-203 21673941-1 2011 We have in vitro tested the ability of common, commercially available, cholinesterase reactivators (pralidoxime, obidoxime, methoxime, trimedoxime and HI-6) to reactivate human acetylcholinesterase (AChE), inhibited by five structurally different organophosphate pesticides and inhibitors (paraoxon, dichlorvos, DFP, leptophos-oxon and methamidophos). Organophosphates 247-262 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-197 21673941-1 2011 We have in vitro tested the ability of common, commercially available, cholinesterase reactivators (pralidoxime, obidoxime, methoxime, trimedoxime and HI-6) to reactivate human acetylcholinesterase (AChE), inhibited by five structurally different organophosphate pesticides and inhibitors (paraoxon, dichlorvos, DFP, leptophos-oxon and methamidophos). Dichlorvos 300-310 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-197 21120745-1 2011 Organophosphate (OP) nerve agents such as sarin, soman, tabun, and O-ethyl S-[2-(diisopropylamino) ethyl] methylphosphonothioate (VX) do not react solely with acetylcholinesterase (AChE). VX 130-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 21120745-1 2011 Organophosphate (OP) nerve agents such as sarin, soman, tabun, and O-ethyl S-[2-(diisopropylamino) ethyl] methylphosphonothioate (VX) do not react solely with acetylcholinesterase (AChE). VX 130-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 20617372-2 2011 The enzyme array has been constructed by spotting of pH sensitive fluorophore 2-phenyl-4-[4-(1,4,7,10-tetraoxa-13-azacycloopentadecyl)benzylidene]oxazol-5-one and acetylcholinesterase doped in tetraethoxysilane/chitosan matrix via a microarrayer. tetraethoxysilane 193-210 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-183 20617372-2 2011 The enzyme array has been constructed by spotting of pH sensitive fluorophore 2-phenyl-4-[4-(1,4,7,10-tetraoxa-13-azacycloopentadecyl)benzylidene]oxazol-5-one and acetylcholinesterase doped in tetraethoxysilane/chitosan matrix via a microarrayer. Chitosan 211-219 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-183 21673941-1 2011 We have in vitro tested the ability of common, commercially available, cholinesterase reactivators (pralidoxime, obidoxime, methoxime, trimedoxime and HI-6) to reactivate human acetylcholinesterase (AChE), inhibited by five structurally different organophosphate pesticides and inhibitors (paraoxon, dichlorvos, DFP, leptophos-oxon and methamidophos). Isoflurophate 312-315 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-197 21673941-1 2011 We have in vitro tested the ability of common, commercially available, cholinesterase reactivators (pralidoxime, obidoxime, methoxime, trimedoxime and HI-6) to reactivate human acetylcholinesterase (AChE), inhibited by five structurally different organophosphate pesticides and inhibitors (paraoxon, dichlorvos, DFP, leptophos-oxon and methamidophos). leptophos oxon 317-331 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-197 21673941-1 2011 We have in vitro tested the ability of common, commercially available, cholinesterase reactivators (pralidoxime, obidoxime, methoxime, trimedoxime and HI-6) to reactivate human acetylcholinesterase (AChE), inhibited by five structurally different organophosphate pesticides and inhibitors (paraoxon, dichlorvos, DFP, leptophos-oxon and methamidophos). methamidophos 336-349 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-197 21673941-4 2011 According to our results, the best broad-spectrum AChE reactivators were trimedoxime and obidoxime in the case of paraoxon, leptophos-oxon, and methamidophos-inhibited AChE. Trimedoxime 73-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 21673941-4 2011 According to our results, the best broad-spectrum AChE reactivators were trimedoxime and obidoxime in the case of paraoxon, leptophos-oxon, and methamidophos-inhibited AChE. Trimedoxime 73-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-172 21673941-4 2011 According to our results, the best broad-spectrum AChE reactivators were trimedoxime and obidoxime in the case of paraoxon, leptophos-oxon, and methamidophos-inhibited AChE. Obidoxime Chloride 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 21673941-4 2011 According to our results, the best broad-spectrum AChE reactivators were trimedoxime and obidoxime in the case of paraoxon, leptophos-oxon, and methamidophos-inhibited AChE. Obidoxime Chloride 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-172 21673941-4 2011 According to our results, the best broad-spectrum AChE reactivators were trimedoxime and obidoxime in the case of paraoxon, leptophos-oxon, and methamidophos-inhibited AChE. Paraoxon 114-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 21673941-4 2011 According to our results, the best broad-spectrum AChE reactivators were trimedoxime and obidoxime in the case of paraoxon, leptophos-oxon, and methamidophos-inhibited AChE. leptophos oxon 124-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 21673941-4 2011 According to our results, the best broad-spectrum AChE reactivators were trimedoxime and obidoxime in the case of paraoxon, leptophos-oxon, and methamidophos-inhibited AChE. methamidophos 144-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 21673941-4 2011 According to our results, the best broad-spectrum AChE reactivators were trimedoxime and obidoxime in the case of paraoxon, leptophos-oxon, and methamidophos-inhibited AChE. methamidophos 144-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-172 21673941-6 2011 In the case of methamidophos-inhibited AChE, the lower oxime concentration (10(-5) M) had higher reactivation ability than the 10(-4) M concentration. methamidophos 15-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 21673941-6 2011 In the case of methamidophos-inhibited AChE, the lower oxime concentration (10(-5) M) had higher reactivation ability than the 10(-4) M concentration. Oximes 55-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 21673941-7 2011 Therefore, we evaluated the reactivation ability of obidoxime in a concentration range of 10(-3)-10(-7) M. The reactivation of methamidophos-inhibited AChE with different obidoxime concentrations resulted in a bell shaped curve with maximum reactivation at 10(-5) M. In the case of BChE, no reactivator exceeded 15% reactivation ability and therefore none of the oximes can be recommended as a candidate for "pseudocatalytic" bioscavengers with BChE. Obidoxime Chloride 52-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 21673941-7 2011 Therefore, we evaluated the reactivation ability of obidoxime in a concentration range of 10(-3)-10(-7) M. The reactivation of methamidophos-inhibited AChE with different obidoxime concentrations resulted in a bell shaped curve with maximum reactivation at 10(-5) M. In the case of BChE, no reactivator exceeded 15% reactivation ability and therefore none of the oximes can be recommended as a candidate for "pseudocatalytic" bioscavengers with BChE. methamidophos 127-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 21673941-7 2011 Therefore, we evaluated the reactivation ability of obidoxime in a concentration range of 10(-3)-10(-7) M. The reactivation of methamidophos-inhibited AChE with different obidoxime concentrations resulted in a bell shaped curve with maximum reactivation at 10(-5) M. In the case of BChE, no reactivator exceeded 15% reactivation ability and therefore none of the oximes can be recommended as a candidate for "pseudocatalytic" bioscavengers with BChE. Obidoxime Chloride 171-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 21673941-7 2011 Therefore, we evaluated the reactivation ability of obidoxime in a concentration range of 10(-3)-10(-7) M. The reactivation of methamidophos-inhibited AChE with different obidoxime concentrations resulted in a bell shaped curve with maximum reactivation at 10(-5) M. In the case of BChE, no reactivator exceeded 15% reactivation ability and therefore none of the oximes can be recommended as a candidate for "pseudocatalytic" bioscavengers with BChE. Oximes 363-369 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 21432054-3 2011 Because of its physiological role, Ache has long been considered a highly specific biomarker for organisms exposed to anticholinesterasic agents, primarily agro-chemicals (organophosphate and carbamate pesticides). Organophosphates 172-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 21432054-3 2011 Because of its physiological role, Ache has long been considered a highly specific biomarker for organisms exposed to anticholinesterasic agents, primarily agro-chemicals (organophosphate and carbamate pesticides). Carbamates 192-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 21087026-1 2010 Human red blood cell acetylcholinesterase was incorporated into planar lipid membranes deposited on alkanethiol self-assembled monolayers (SAMs) on gold substrates. alkanethiol 100-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 21087026-1 2010 Human red blood cell acetylcholinesterase was incorporated into planar lipid membranes deposited on alkanethiol self-assembled monolayers (SAMs) on gold substrates. SAMS Peptide 139-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 21087026-6 2010 In this work, we report acetylcholinesterase immobilization in lipid membranes deposited on SAMs formed on the gold surface and compare its activity to enzyme in solution. SAMS Peptide 92-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 21156143-1 2010 A molecular dynamics study of traffic of thiocholine within the active-site gorge of acetylcholinesterase. Thiocholine 41-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 21156143-2 2010 The principal role of acetylcholinesterase is termination of nerve impulse transmission at cholinergic synapses, by rapid hydrolysis of the neurotransmitter acetylcholine to acetate and choline. Acetates 174-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 21156143-6 2010 Here, multiple conventional molecular dynamics simulations have been performed to investigate the clearance of the product, thiocholine, from the active-site gorge of acetylcholinesterase. Thiocholine 124-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-187 20888357-5 2010 By applying a modified kinetic approach, allowing the use of necessary high MMB-4 concentrations, it was possible to determine the reactivation constants with sarin-, cyclosarin-, VX-, VR- and tabun-inhibited AChE. cyclohexyl methylphosphonofluoridate 167-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-213 20888357-8 2010 Due to the high reactivity of MMB-4 a rapid reactivation of inhibited AChE can be anticipated at adequate oxime concentrations which are substantially higher compared to HI-6. Oximes 106-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 20888357-8 2010 Due to the high reactivity of MMB-4 a rapid reactivation of inhibited AChE can be anticipated at adequate oxime concentrations which are substantially higher compared to HI-6. asoxime chloride 170-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 21058637-5 2010 In particular, acetylcholinesterase inhibition (IC(50) of 7.1 +- 1.3 mg mL(-1)) implies the conjugate"s usefulness in the chemoprevention of Alzheimer"s disease, while the inhibition of alpha-amylase (IC(50) of 9.8 +- 1.1 mg mL(-1)) suggests that the conjugate can be a preferred alternative for inhibition of carbohydrate breakdown and control of glycemic index of food products. Carbohydrates 310-322 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 21052939-0 2010 Synthesis and biological evaluation of 3,6-diaryl-7H-thiazolo[3,2-b] [1,2,4]triazin-7-one derivatives as acetylcholinesterase inhibitors. 3,6-diaryl-7h-thiazolo[3,2-b] [1,2,4]triazin-7-one 39-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 20949898-1 2010 A fluorimetric acetylcholinesterase (AChE) assay was developed and characterized both in solution and with the enzyme entrapped in sol-gel-derived silica. Silicon Dioxide 147-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 20949898-2 2010 The assay is based on a disulfide-thiol interchange reaction between the intramolecularly quenched dimeric dye BODIPY FL l-cystine and thiocholine generated by the AChE-catalyzed hydrolysis of acetylthiocholine (ATCh), which results in a brightly fluorescent monomeric product owing to the cleavage of the disulfide-coupled form of the dye. Disulfides 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 20949898-2 2010 The assay is based on a disulfide-thiol interchange reaction between the intramolecularly quenched dimeric dye BODIPY FL l-cystine and thiocholine generated by the AChE-catalyzed hydrolysis of acetylthiocholine (ATCh), which results in a brightly fluorescent monomeric product owing to the cleavage of the disulfide-coupled form of the dye. Sulfhydryl Compounds 34-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 20949898-2 2010 The assay is based on a disulfide-thiol interchange reaction between the intramolecularly quenched dimeric dye BODIPY FL l-cystine and thiocholine generated by the AChE-catalyzed hydrolysis of acetylthiocholine (ATCh), which results in a brightly fluorescent monomeric product owing to the cleavage of the disulfide-coupled form of the dye. BODIPY-FL L-cystine 111-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 20949898-2 2010 The assay is based on a disulfide-thiol interchange reaction between the intramolecularly quenched dimeric dye BODIPY FL l-cystine and thiocholine generated by the AChE-catalyzed hydrolysis of acetylthiocholine (ATCh), which results in a brightly fluorescent monomeric product owing to the cleavage of the disulfide-coupled form of the dye. Thiocholine 135-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 20949898-2 2010 The assay is based on a disulfide-thiol interchange reaction between the intramolecularly quenched dimeric dye BODIPY FL l-cystine and thiocholine generated by the AChE-catalyzed hydrolysis of acetylthiocholine (ATCh), which results in a brightly fluorescent monomeric product owing to the cleavage of the disulfide-coupled form of the dye. Acetylthiocholine 193-210 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 20949898-2 2010 The assay is based on a disulfide-thiol interchange reaction between the intramolecularly quenched dimeric dye BODIPY FL l-cystine and thiocholine generated by the AChE-catalyzed hydrolysis of acetylthiocholine (ATCh), which results in a brightly fluorescent monomeric product owing to the cleavage of the disulfide-coupled form of the dye. Acetylthiocholine 212-216 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 20949898-2 2010 The assay is based on a disulfide-thiol interchange reaction between the intramolecularly quenched dimeric dye BODIPY FL l-cystine and thiocholine generated by the AChE-catalyzed hydrolysis of acetylthiocholine (ATCh), which results in a brightly fluorescent monomeric product owing to the cleavage of the disulfide-coupled form of the dye. Disulfides 306-315 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 20949898-4 2010 The assay was extended to the fabrication of functional AChE microarrays using contact pin-printing of sol-gel-derived silica. Silicon Dioxide 119-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 20880702-2 2010 Compound 10b, with a cyclohexylamino group linked to berberine by a three carbon spacer, gave the most potent inhibitor activity with an IC(50) of 0.020 muM for AChE. Berberine 53-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-165 20943395-0 2010 4-Phenylcoumarins from Mesua elegans with acetylcholinesterase inhibitory activity. 4-phenylcoumarin 0-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 20943395-1 2010 A significant acetylcholinesterase (AChE) inhibitory activity was observed for the hexane extract from the bark of Mesua elegans (Clusiaceae). Hexanes 83-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 20943395-1 2010 A significant acetylcholinesterase (AChE) inhibitory activity was observed for the hexane extract from the bark of Mesua elegans (Clusiaceae). Hexanes 83-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 20466502-0 2010 Production and on-line acetylcholinesterase bioactivity profiling of chemical and biological degradation products of tacrine. Tacrine 117-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 20655881-1 2010 The toxicity of organophosphorus (OP) nerve agents is manifested through irreversible inhibition of acetylcholinesterase (AChE) at the cholinergic synapses, which stops nerve signal transmission, resulting in a cholinergic crisis and eventually death of the poisoned person. organophosphorus 16-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 20655881-1 2010 The toxicity of organophosphorus (OP) nerve agents is manifested through irreversible inhibition of acetylcholinesterase (AChE) at the cholinergic synapses, which stops nerve signal transmission, resulting in a cholinergic crisis and eventually death of the poisoned person. organophosphorus 16-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 20655881-6 2010 A homology model for wild-type Bo AChE was built using the recently published crystal structure of human AChE and used to generate models of 2-PAM and HI-6 bound to the active-sites of GF- and VR-inhibited Bo AChEs before nucleophilic attack. pralidoxime 141-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 20655881-6 2010 A homology model for wild-type Bo AChE was built using the recently published crystal structure of human AChE and used to generate models of 2-PAM and HI-6 bound to the active-sites of GF- and VR-inhibited Bo AChEs before nucleophilic attack. asoxime chloride 151-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 20739347-11 2010 In patients there was significant decline in N-acetyl-aspartate:creatine/phosphocreatine (mean: 2.2%/year; 95% confidence interval: 0.9-3.5) and N-acetyl-aspartate:myo-inositol (mean: 3.7%/year; 95% confidence interval: 1.7-5.7), with no evidence for influence by age, disease severity or acetylcholinesterase inhibitor use. N-acetylaspartate 45-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 289-309 20663605-1 2010 INTRODUCTION: For more than 50 years the acetylcholinesterase inhibitor pyridostigmine bromide has been the drug of choice in the symptomatic therapy for myasthenia gravis. Pyridostigmine Bromide 72-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 21787660-6 2010 The results showed that AChE activity was significantly inhibited by omethoate, but was not altered by GSH treatment. dimethoxon 69-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 20883446-6 2010 Glycosylphosphatidylinositol-linked acetylcholinesterase dimers and hydrophilic butyrylcholinesterase tetramers predominated in control and cancerous kidney. Glycosylphosphatidylinositols 0-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 20837887-4 2010 Alternatively, the acetylcholinesterase inhibitor, pyridostigmine, can increase sympathetic tone by improving ganglionic cholinergic neurotransmission. Pyridostigmine Bromide 51-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 20635332-6 2010 It seems obvious that oximes are weakly penetrating the BBB, with minimal brain AChE reactivation (<5%) in important functional areas, such as the ponto-medullar. Oximes 22-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 21151975-4 2010 The standard treatment of OP poisoning includes a combination of a muscarinic antagonist and an AChE reactivator (oxime). Oximes 114-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 21151975-8 2010 In general, the nanoparticulate transported oximes achieved a better reactivation of OP-inhibited AChE than free oximes. Oximes 44-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 21151975-8 2010 In general, the nanoparticulate transported oximes achieved a better reactivation of OP-inhibited AChE than free oximes. Oximes 113-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 21127466-1 2010 A new tacrine based cholinesterase inhibitor, N-(bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine (1), was designed and synthesized to interact with specific regions of human acetylcholinesterase and human butyrylcholinesterase. Tacrine 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 190-242 21127466-1 2010 A new tacrine based cholinesterase inhibitor, N-(bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine (1), was designed and synthesized to interact with specific regions of human acetylcholinesterase and human butyrylcholinesterase. N-(bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine 46-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 190-242 20951037-1 2010 Series of pyrolidine analogues were synthesized and examined as acetylcholinesterase (AChE) inhibitors. pyrrolidine 10-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 20926161-3 2010 Derivatives of N-benzylpiperazine (16-25) were selective BuChE inhibitors with 3-(2-(4-benzylpiperazin-1-yl)-2-oxoethyl)-phenyl butylcarbamate (22) being the most potent compound (pIC50=5.00) while a series of carbamate derivatives of N-benzylpiperidine (5-14) displayed non-selective BuChE/AChE inhibitory activity. N-benzylpiperazine 15-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 291-295 20353344-9 2010 The results showed that the electronic changes have ignorable effects, steric influence is important in some cases, but the lipophilicity parameter is the most significant factor in hAChE inhibition by bisphosphonates. Diphosphonates 202-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-187 21116228-3 2010 All of the benzofuran derivatives have weak anti-AChE activities compared with the reference compound, donepezil. benzofuran 11-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 21116228-3 2010 All of the benzofuran derivatives have weak anti-AChE activities compared with the reference compound, donepezil. Donepezil 103-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 21052939-3 2010 The study of AChE inhibitory activity was carried out using the Ellman colorimetric assay with huperzine-A as the positive control drug. huperzine A 95-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 20510679-1 2010 The therapeutic approach of organophosphorus compound (OP) intoxications is to reactivate the inhibited enzyme acetylcholinesterase (AChE). organophosphorus 28-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 22778810-3 2010 The identified lead, HLA20A, exhibits little affinity for metal (Fe, Cu, and Zn) ions but can be activated following inhibition of AChE to liberate an active chelator, HLA20. Iron 65-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 22778810-3 2010 The identified lead, HLA20A, exhibits little affinity for metal (Fe, Cu, and Zn) ions but can be activated following inhibition of AChE to liberate an active chelator, HLA20. Copper 69-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 22778810-3 2010 The identified lead, HLA20A, exhibits little affinity for metal (Fe, Cu, and Zn) ions but can be activated following inhibition of AChE to liberate an active chelator, HLA20. Zinc 77-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 22778810-5 2010 HLA20A inhibited AChE in a time and concentration dependent manner with an HLA20A-AChE complex constant (K(i)) of 9.66 x 10(-6) M, a carbamylation rate (k(+2)) of 0.14 min(-1), and a second-order rate (k(i)) of 1.45 x 10 (4) M(-1) min(-1), comparable to those of rivastigmine. Rivastigmine 263-275 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 22778810-5 2010 HLA20A inhibited AChE in a time and concentration dependent manner with an HLA20A-AChE complex constant (K(i)) of 9.66 x 10(-6) M, a carbamylation rate (k(+2)) of 0.14 min(-1), and a second-order rate (k(i)) of 1.45 x 10 (4) M(-1) min(-1), comparable to those of rivastigmine. Rivastigmine 263-275 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 20882513-1 2010 Poisoning with organophosphorus compounds (OP), e.g. pesticides and nerve agents, causes inhibition of acetylcholinesterase (AChE) by phosphylation of the active site serine residue. Organophosphorus Compounds 15-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 20882513-1 2010 Poisoning with organophosphorus compounds (OP), e.g. pesticides and nerve agents, causes inhibition of acetylcholinesterase (AChE) by phosphylation of the active site serine residue. Organophosphorus Compounds 15-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 20882513-1 2010 Poisoning with organophosphorus compounds (OP), e.g. pesticides and nerve agents, causes inhibition of acetylcholinesterase (AChE) by phosphylation of the active site serine residue. Serine 167-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 20882513-1 2010 Poisoning with organophosphorus compounds (OP), e.g. pesticides and nerve agents, causes inhibition of acetylcholinesterase (AChE) by phosphylation of the active site serine residue. Serine 167-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 20719927-8 2010 Application of the acetylcholinesterase inhibitor neostigmine significantly decreased the amplitude of glutamatergic neurotransmission to CVNs on stimulation of trigeminal fibers. Neostigmine 50-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 29255395-6 2010 Increased lipid peroxidation, surge in reactive oxygen species (ROS), depressed antioxidant defense, increased accumulation of cadmium, differential alterations in trace elements and decreased activity of AChE were the features of cadmium toxicity. Cadmium 231-238 acetylcholinesterase (Cartwright blood group) Homo sapiens 205-209 20655346-3 2010 Galantamine is an acetylcholinesterase (AChE) inhibitor widely used for patients with AD. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 20655346-3 2010 Galantamine is an acetylcholinesterase (AChE) inhibitor widely used for patients with AD. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 20510679-1 2010 The therapeutic approach of organophosphorus compound (OP) intoxications is to reactivate the inhibited enzyme acetylcholinesterase (AChE). organophosphorus 28-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 20510679-4 2010 In the present study, reactivation kinetics of tabun-, sarin-, cyclosarin-, VX- or paraoxon-ethyl-inhibited human AChE (hAChE) with a homologous series of bis-ortho-pyridiniumaldoximes, Ortho-4 - Ortho-9, was investigated with a robot-assisted setting, allowing determination of second-order reactivation rate constants as well as model calculations. cyclohexyl methylphosphonofluoridate 63-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 20510679-4 2010 In the present study, reactivation kinetics of tabun-, sarin-, cyclosarin-, VX- or paraoxon-ethyl-inhibited human AChE (hAChE) with a homologous series of bis-ortho-pyridiniumaldoximes, Ortho-4 - Ortho-9, was investigated with a robot-assisted setting, allowing determination of second-order reactivation rate constants as well as model calculations. cyclohexyl methylphosphonofluoridate 63-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-125 20510679-7 2010 Reactivity increased from Ortho-4 to Ortho-6 for PXE- and VX-inhibited hAChE and from Ortho-4 to Ortho-7 for GA-inhibited hAChE and decreased again with Ortho-8 and Ortho-9. Gallium 109-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-127 20510679-8 2010 In contrast, k(r) decreased with increasing linker length for sarin- and cyclosarin-inhibited hAChE. cyclohexyl methylphosphonofluoridate 73-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-99 20510679-10 2010 Hence, the ratios of K(I)/K(D) and of K(I)/k(r2) showed that in almost all cases the affinity of Ortho-N to the native hAChE was higher than to OP-inhibited enzyme. Orthon 97-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-124 20510679-11 2010 Model calculations indicated that Ortho-6 - Ortho-9 could be superior to obidoxime in reactivating tabun-inhibited hAChE. Obidoxime Chloride 73-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-120 20510679-12 2010 Finally, these data emphasize the need to develop oximes with a higher selective affinity towards OP-inhibited hAChE in order to minimize possible side effects. Oximes 50-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-116 20684567-2 2010 The predictive pharmacophore model (correlation = 0.955) with one H-bond donor and three hydrophobic features was developed using HypoGen on a training set of 24 carbamates as AChE inhibitors. Carbamates 162-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 20684567-4 2010 The pharmacophore-based VS of virtual library led to the identification of novel carbamates as potent AChE inhibitors. Carbamates 81-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 19883634-1 2010 It is generally accepted that inhibition of acetylcholinesterase (AChE) is the most important acute toxic action of organophosphorus compounds, leading to accumulation of acetylcholine followed by a dysfunction of cholinergic signaling. Organophosphorus Compounds 116-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 19883634-1 2010 It is generally accepted that inhibition of acetylcholinesterase (AChE) is the most important acute toxic action of organophosphorus compounds, leading to accumulation of acetylcholine followed by a dysfunction of cholinergic signaling. Organophosphorus Compounds 116-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 19883634-1 2010 It is generally accepted that inhibition of acetylcholinesterase (AChE) is the most important acute toxic action of organophosphorus compounds, leading to accumulation of acetylcholine followed by a dysfunction of cholinergic signaling. Acetylcholine 44-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 19883634-8 2010 Also oxime therapy in organophosphorus poisoning apparently gives perplexing results: Oximes are usually able to reactivate diethylphosphorylated AChE, but the efficiency may be occasionally markedly smaller than expected from kinetic data. Oximes 5-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 19883634-8 2010 Also oxime therapy in organophosphorus poisoning apparently gives perplexing results: Oximes are usually able to reactivate diethylphosphorylated AChE, but the efficiency may be occasionally markedly smaller than expected from kinetic data. Oximes 86-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 19883634-9 2010 Dimethylphosphorylated AChE is in general less amenable to oxime therapy, which largely fails in some cases of dimethoate poisoning where aging was much faster than expected from a dimethylphosphorylated enzyme. Oximes 59-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 19917271-2 2010 The presently established acetylcholinesterase (AChE) reactivators (oximes), e.g. obidoxime and pralidoxime, are insufficient against a number of nerve agents and there is ongoing debate on the benefit of oxime treatment in human OP pesticide poisoning. Oximes 68-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 19917271-2 2010 The presently established acetylcholinesterase (AChE) reactivators (oximes), e.g. obidoxime and pralidoxime, are insufficient against a number of nerve agents and there is ongoing debate on the benefit of oxime treatment in human OP pesticide poisoning. Oximes 68-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 19917271-2 2010 The presently established acetylcholinesterase (AChE) reactivators (oximes), e.g. obidoxime and pralidoxime, are insufficient against a number of nerve agents and there is ongoing debate on the benefit of oxime treatment in human OP pesticide poisoning. Obidoxime Chloride 82-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 19917271-2 2010 The presently established acetylcholinesterase (AChE) reactivators (oximes), e.g. obidoxime and pralidoxime, are insufficient against a number of nerve agents and there is ongoing debate on the benefit of oxime treatment in human OP pesticide poisoning. Obidoxime Chloride 82-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 19917271-2 2010 The presently established acetylcholinesterase (AChE) reactivators (oximes), e.g. obidoxime and pralidoxime, are insufficient against a number of nerve agents and there is ongoing debate on the benefit of oxime treatment in human OP pesticide poisoning. Oximes 68-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 19917271-2 2010 The presently established acetylcholinesterase (AChE) reactivators (oximes), e.g. obidoxime and pralidoxime, are insufficient against a number of nerve agents and there is ongoing debate on the benefit of oxime treatment in human OP pesticide poisoning. Oximes 68-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 19917271-5 2010 Kinetic studies on the various interactions between erythrocyte AChE from various species, structurally different OP and different oximes provided a basis for the initial assessment of the ability of oximes to reactivate inhibited AChE. Oximes 200-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 19917271-5 2010 Kinetic studies on the various interactions between erythrocyte AChE from various species, structurally different OP and different oximes provided a basis for the initial assessment of the ability of oximes to reactivate inhibited AChE. Oximes 200-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 231-235 19917271-6 2010 In the present study, in vitro enzyme-kinetic and pharmacokinetic data from a minipig model of dimethoate poisoning and oxime treatment were used to calculate dynamic changes of AChE activities. Dimethoate 95-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-182 19917271-6 2010 In the present study, in vitro enzyme-kinetic and pharmacokinetic data from a minipig model of dimethoate poisoning and oxime treatment were used to calculate dynamic changes of AChE activities. Oximes 120-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-182 20005217-1 2010 We have shown previously that conjugation of polyethylene glycol (PEG) chains to recombinant human acetylcholinesterase (rHuAChE) results in the extension of its residence time in the circulation of mice and monkeys [1,2]. Polyethylene Glycols 45-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 20005217-1 2010 We have shown previously that conjugation of polyethylene glycol (PEG) chains to recombinant human acetylcholinesterase (rHuAChE) results in the extension of its residence time in the circulation of mice and monkeys [1,2]. Polyethylene Glycols 66-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 20005217-2 2010 By profiling the pharmacokinetic behavior of an array of well-defined hypolysine human mutant AChE molecules following PEGylation, we now determine that the duration of these enzyme forms in the circulation of rhesus macaques correlates with their number of appended PEG moieties, and is influenced by the actual location of the PEG chains at the molecule surface, as well. Polyethylene Glycols 119-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 20005217-2 2010 By profiling the pharmacokinetic behavior of an array of well-defined hypolysine human mutant AChE molecules following PEGylation, we now determine that the duration of these enzyme forms in the circulation of rhesus macaques correlates with their number of appended PEG moieties, and is influenced by the actual location of the PEG chains at the molecule surface, as well. Polyethylene Glycols 267-270 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 20005217-5 2010 Thus, an inverse relationship between anti-AChE antibody production and PEG loading was observed following repeated administration of the different PEGylated hypolysine human AChEs to mice. Polyethylene Glycols 72-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 20005217-5 2010 Thus, an inverse relationship between anti-AChE antibody production and PEG loading was observed following repeated administration of the different PEGylated hypolysine human AChEs to mice. hypolysine 158-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 20005217-10 2010 This selected 4-PEG F338A-AChE can serve as a paradigm for new generation OP-bioscavengers, specifically tailored for prophylactic treatment against toxic OP-agents. 4-peg 14-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 20036651-8 2010 In this model neostigmine and VX affected neuromuscular transmission as anticipated from their known actions on AChE. Neostigmine 14-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 20036651-8 2010 In this model neostigmine and VX affected neuromuscular transmission as anticipated from their known actions on AChE. VX 30-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 20036651-12 2010 The results obtained with paraoxon favourably correlate with data from clinical findings of parathion-poisoned patients where the correlation of neuromuscular transmission with the activity of erythrocyte AChE could be established. Parathion 92-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 205-209 20105433-4 2010 Beside atropine as competitive antagonist of ACh at muscarinic ACh receptors oximes as reactivators of OP-inhibited AChE are a mainstay of standard antidotal treatment. Atropine 7-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 20105433-4 2010 Beside atropine as competitive antagonist of ACh at muscarinic ACh receptors oximes as reactivators of OP-inhibited AChE are a mainstay of standard antidotal treatment. Acetylcholine 45-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 20105433-5 2010 However, human AChE inhibited by certain OP is rather resistant to oxime-induced reactivation. Oximes 67-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 20105433-8 2010 Rate constants for the inhibition of human AChE by OPs, spontaneous dealkylation and reactivation as well as reactivation by obidoxime and HI 6 of OP-inhibited human AChE were determined. Obidoxime Chloride 125-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 20109441-3 2010 We previously reported a free cysteine (Cys) residue at the entrance to the AChE active site in some insects but not higher vertebrates. Cysteine 30-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 20109441-3 2010 We previously reported a free cysteine (Cys) residue at the entrance to the AChE active site in some insects but not higher vertebrates. Cysteine 40-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 20109441-4 2010 We also reported Cys-targeting methanethiosulfonate molecules (AMTSn), which, under conditions that spared human AChE, caused total irreversible inhibition of aphid AChE, 95% inhibition of AChE from the malaria vector mosquito (Anopheles gambia), and >80% inhibition of activity from the yellow fever mosquito (Aedes aegypti) and northern house mosquito (Culex pipiens). Cysteine 17-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 20109441-4 2010 We also reported Cys-targeting methanethiosulfonate molecules (AMTSn), which, under conditions that spared human AChE, caused total irreversible inhibition of aphid AChE, 95% inhibition of AChE from the malaria vector mosquito (Anopheles gambia), and >80% inhibition of activity from the yellow fever mosquito (Aedes aegypti) and northern house mosquito (Culex pipiens). Cysteine 17-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 20109441-4 2010 We also reported Cys-targeting methanethiosulfonate molecules (AMTSn), which, under conditions that spared human AChE, caused total irreversible inhibition of aphid AChE, 95% inhibition of AChE from the malaria vector mosquito (Anopheles gambia), and >80% inhibition of activity from the yellow fever mosquito (Aedes aegypti) and northern house mosquito (Culex pipiens). Cysteine 17-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 20109441-4 2010 We also reported Cys-targeting methanethiosulfonate molecules (AMTSn), which, under conditions that spared human AChE, caused total irreversible inhibition of aphid AChE, 95% inhibition of AChE from the malaria vector mosquito (Anopheles gambia), and >80% inhibition of activity from the yellow fever mosquito (Aedes aegypti) and northern house mosquito (Culex pipiens). methanethiosulfonate 31-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 20109441-4 2010 We also reported Cys-targeting methanethiosulfonate molecules (AMTSn), which, under conditions that spared human AChE, caused total irreversible inhibition of aphid AChE, 95% inhibition of AChE from the malaria vector mosquito (Anopheles gambia), and >80% inhibition of activity from the yellow fever mosquito (Aedes aegypti) and northern house mosquito (Culex pipiens). methanethiosulfonate 31-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 20109441-4 2010 We also reported Cys-targeting methanethiosulfonate molecules (AMTSn), which, under conditions that spared human AChE, caused total irreversible inhibition of aphid AChE, 95% inhibition of AChE from the malaria vector mosquito (Anopheles gambia), and >80% inhibition of activity from the yellow fever mosquito (Aedes aegypti) and northern house mosquito (Culex pipiens). methanethiosulfonate 31-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 20138030-1 2010 By rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase terminates neurotransmission at cholinergic synapses. Acetylcholine 45-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 20138030-3 2010 The powerful toxicity of organophosphate poisons is attributed primarily to their potent inhibition of acetylcholinesterase. Organophosphates 25-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 20138030-5 2010 Many organophosphates and carbamates serve as potent insecticides, by selectively inhibiting insect acetylcholinesterase. Organophosphates 5-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 20138030-5 2010 Many organophosphates and carbamates serve as potent insecticides, by selectively inhibiting insect acetylcholinesterase. Carbamates 26-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 20144593-0 2010 Synthesis and evaluation of novel analogues of vitamin B6 as reactivators of tabun and paraoxon inhibited acetylcholinesterase. Vitamin B 6 47-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 20144593-4 2010 However, tested oximes were not efficient in reactivation of either tabun or paraoxon inhibited AChE. Paraoxon 77-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 20153305-2 2010 One of these molecules is acetylcholinesterase (AChE) that regulates acetylcholine levels. Acetylcholine 26-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 20156428-1 2010 The phosphonylation mechanism of AChE and the S203C mutation by sarin (GB) is evaluated using two reaction schemes: a small model nucleophile (ethoxide, CH(3)CH(2)O(-)) and quantum mechanical/molecular mechanical (QM/MM) simulations. ethoxyd 143-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 20156428-6 2010 Hydrogen-bonding interactions between the fluoride leaving group of GB with Y124 in AChE are observed throughout the reaction profile. Hydrogen 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 20156428-6 2010 Hydrogen-bonding interactions between the fluoride leaving group of GB with Y124 in AChE are observed throughout the reaction profile. Fluorides 42-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 20156428-6 2010 Hydrogen-bonding interactions between the fluoride leaving group of GB with Y124 in AChE are observed throughout the reaction profile. y124 76-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 20156428-7 2010 The S203C mutation alters the relative energetics of the reaction, increasing the energy barrier for formation of the penta-coordinate intermediate to a value of 4.5 kcal/mol; moreover, the penta-coordinate intermediate (as product) is stabilized by an additional 6 kcal/mol when compared to wild-type AChE. PENTA 118-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 302-306 20156428-7 2010 The S203C mutation alters the relative energetics of the reaction, increasing the energy barrier for formation of the penta-coordinate intermediate to a value of 4.5 kcal/mol; moreover, the penta-coordinate intermediate (as product) is stabilized by an additional 6 kcal/mol when compared to wild-type AChE. PENTA 190-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 302-306 20156431-2 2010 The C-terminal region of AChE has been shown to be responsible for non-cholinergic actions of AChE by binding to an allosteric site on the alpha 7-nicotinic acetylcholine receptor, thereby causing calcium influx; the resultant signal has trophic effects in immature neurons, but toxic effects in mature neurons. Calcium 197-204 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 20156431-2 2010 The C-terminal region of AChE has been shown to be responsible for non-cholinergic actions of AChE by binding to an allosteric site on the alpha 7-nicotinic acetylcholine receptor, thereby causing calcium influx; the resultant signal has trophic effects in immature neurons, but toxic effects in mature neurons. Calcium 197-204 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 20178777-1 2010 Acetylcholinesterase (AChE), a highly polymorphic enzyme with various splicing variants and molecular isoforms, plays an essential role in the cholinergic neurotransmission by hydrolyzing acetylcholine into choline and acetate. Acetylcholine 188-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 20178777-1 2010 Acetylcholinesterase (AChE), a highly polymorphic enzyme with various splicing variants and molecular isoforms, plays an essential role in the cholinergic neurotransmission by hydrolyzing acetylcholine into choline and acetate. Acetylcholine 188-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 20178777-1 2010 Acetylcholinesterase (AChE), a highly polymorphic enzyme with various splicing variants and molecular isoforms, plays an essential role in the cholinergic neurotransmission by hydrolyzing acetylcholine into choline and acetate. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 20178777-1 2010 Acetylcholinesterase (AChE), a highly polymorphic enzyme with various splicing variants and molecular isoforms, plays an essential role in the cholinergic neurotransmission by hydrolyzing acetylcholine into choline and acetate. Acetates 219-226 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 20178777-1 2010 Acetylcholinesterase (AChE), a highly polymorphic enzyme with various splicing variants and molecular isoforms, plays an essential role in the cholinergic neurotransmission by hydrolyzing acetylcholine into choline and acetate. Acetates 219-226 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 20178777-2 2010 The AChE(T) variant is expressed in the brain and muscle: this subunit forms non-amphiphilic tetramers with a collagen tail (ColQ) as asymmetric AChE (A(12) AChE) in muscle, and amphiphilic tetramers with a proline-rich membrane anchor (PRiMA) as globular AChE (G(4) AChE) in the brain and muscle. Proline 207-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 20227398-1 2010 The US Army utilizes pralidoxime (2-PAM) for the reactivation of OP-inhibited AChE. pralidoxime 21-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 20227398-3 2010 To address this problem of central nervous system AChE reactivation, novel sugar-oxime conjugates were utilized. sugar-oxime 75-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 20227398-5 2010 Eight previously reported, but understudied sugar-oximes, as well as six novel sugar-oximes were synthesized, and their ability to reactivate both human red blood cell AChE and plasma butyrylcholinesterase poisoned with DFP, paraoxon, sarin and VX were tested. sugar-oximes 44-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-172 20227398-5 2010 Eight previously reported, but understudied sugar-oximes, as well as six novel sugar-oximes were synthesized, and their ability to reactivate both human red blood cell AChE and plasma butyrylcholinesterase poisoned with DFP, paraoxon, sarin and VX were tested. sugar-oximes 79-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-172 20303930-1 2010 Fluorogenic organophosphate inhibitors of acetylcholinesterase (AChE) homologous in structure to nerve agents provide useful probes for high throughput screening of mammalian paraoxonase (PON1) libraries generated by directed evolution of an engineered PON1 variant with wild-type like specificity (rePON1). Organophosphates 12-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 20338153-15 2010 Determination of the three-dimensional structure of BChE and AChE conjugated to different OPs showed that aged adducts form a salt bridge with the protonated catalytic histidine. Histidine 168-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 20338155-7 2010 Decreased apoptosis in siRNA AChE silenced myoblasts and increased AChE expression in staurosporine-treated myoblasts confirmed AChE involvement in apoptosis. Staurosporine 86-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 20338155-7 2010 Decreased apoptosis in siRNA AChE silenced myoblasts and increased AChE expression in staurosporine-treated myoblasts confirmed AChE involvement in apoptosis. Staurosporine 86-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 20338155-8 2010 The three AChE splice variants were differently affected by staurosporine-induced apoptosis. Staurosporine 60-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-14 20338155-10 2010 In the light of these findings AChE appears to be a potential therapeutic target at muscle injuries including organophosphate myopathy. Organophosphates 110-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 20338157-2 2010 Its property to express a whole set of molecules related to the cholinergic neurotransmission system, including active acetylcholinesterase (AChE, EC 3.1.1.7) makes it a good alternative model for testing the effects of neurotoxic compounds, such as organophosphorus (OP) insecticides, whose primary target is the inhibition of AChE activity. organophosphorus 250-266 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 20338157-2 2010 Its property to express a whole set of molecules related to the cholinergic neurotransmission system, including active acetylcholinesterase (AChE, EC 3.1.1.7) makes it a good alternative model for testing the effects of neurotoxic compounds, such as organophosphorus (OP) insecticides, whose primary target is the inhibition of AChE activity. organophosphorus 250-266 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 20347727-2 2010 To investigate the ChE interaction with organophosphorus inhibitors (OPIs) in more detail, we have performed in silico docking of the series of O,O-dialkylfluorophosphates into active center of different ChEs - both from mammals (human and mouse AChEs and horse BChE), and from insects (spring grain aphid AChE belonging to AChE-1 type, and housefly AChE belonging to AChE-2 type). o,o-dialkylfluorophosphates 144-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 246-250 20347727-4 2010 In addition to well-known residues 288 and 290 (Torpedo AChE sequence numbering), we showed an essential influence of residue 400 - a short alkyl residue in mammalian ChEs and phenylalanine in insect ChEs. Phenylalanine 176-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 20350537-0 2010 Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and kinetic analysis. Diterpenes 25-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 20350537-0 2010 Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and kinetic analysis. cryptotanshinone 37-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 20350537-0 2010 Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and kinetic analysis. DIHYDROTANSHINONE 58-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 20350537-2 2010 Current therapeutic intervention for AD is primarily based on the inhibition of brain acetylcholinesterase (AChE) to restore the brain acetylcholine level. Acetylcholine 86-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 20350537-5 2010 Here we characterized the inhibition property of these two diterpenoids towards human AChE and butyrylcholinesterase (BChE). Diterpenes 59-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 20350537-6 2010 Both CT and DT were found to be mixed non-competitive inhibitors for human AChE and an uncompetitive inhibitor for human BChE. cryptotanshinone 5-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 20350537-6 2010 Both CT and DT were found to be mixed non-competitive inhibitors for human AChE and an uncompetitive inhibitor for human BChE. Thymidine 12-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 20382137-0 2010 Investigating the structural influence of surface mutations on acetylcholinesterase inhibition by organophosphorus compounds and oxime reactivation. organophosphorus 98-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 20382137-1 2010 Organophosphates (OPs) exert their toxicity by inhibiting primarily acetylcholinesterase (AChE) and to a lesser extent butyrylcholinesterase (BChE). Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 20382137-1 2010 Organophosphates (OPs) exert their toxicity by inhibiting primarily acetylcholinesterase (AChE) and to a lesser extent butyrylcholinesterase (BChE). Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 20382137-1 2010 Organophosphates (OPs) exert their toxicity by inhibiting primarily acetylcholinesterase (AChE) and to a lesser extent butyrylcholinesterase (BChE). Organophosphates 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 20382137-1 2010 Organophosphates (OPs) exert their toxicity by inhibiting primarily acetylcholinesterase (AChE) and to a lesser extent butyrylcholinesterase (BChE). Organophosphates 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 20382137-3 2010 In this study wild type human AChE and human AChE with residue mutations D134H, D134H_E202Q and D134H_F338A were characterized and investigated for inhibition by OPs and consequent oxime reactivation of phosphylated enzymes. d134h 73-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 20398640-1 2010 The combined quantum mechanical-molecular mechanical (QM/MM) based computational scheme for modeling the structure-reaction rate correlations was elaborated for the hydrolysis of the set of neutral esters in the active site of acetylcholinesterase (AChE). Esters 198-204 acetylcholinesterase (Cartwright blood group) Homo sapiens 227-247 20398640-1 2010 The combined quantum mechanical-molecular mechanical (QM/MM) based computational scheme for modeling the structure-reaction rate correlations was elaborated for the hydrolysis of the set of neutral esters in the active site of acetylcholinesterase (AChE). Esters 198-204 acetylcholinesterase (Cartwright blood group) Homo sapiens 249-253 20412789-0 2010 Interaction kinetics of oximes with native, phosphylated and aged human acetylcholinesterase. Oximes 24-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 20412789-1 2010 Oximes are commonly used nucleophilic reactivators of alkyl phosphorylated and alkyl methylphosphonylated acetylcholinesterase (AChE) and butyrylcholinesterase. Oximes 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 20412789-1 2010 Oximes are commonly used nucleophilic reactivators of alkyl phosphorylated and alkyl methylphosphonylated acetylcholinesterase (AChE) and butyrylcholinesterase. Oximes 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 20412789-3 2010 In this study we determined kinetic constants for interaction of three triazole containing oximes with native human AChE, enzyme diethylphosphorylated by paraoxon, enzyme phosphonylated by VX and cyclosarin as well as enzyme aged upon phosphonylation by soman. Triazoles 71-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 20412789-3 2010 In this study we determined kinetic constants for interaction of three triazole containing oximes with native human AChE, enzyme diethylphosphorylated by paraoxon, enzyme phosphonylated by VX and cyclosarin as well as enzyme aged upon phosphonylation by soman. Oximes 91-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 20412789-4 2010 Stopped-flow kinetics of oxime interaction was monitored using quenching of intrinsic tryptophan fluorescence of AChE as an indicator of oxime binding. Oximes 25-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 20412789-4 2010 Stopped-flow kinetics of oxime interaction was monitored using quenching of intrinsic tryptophan fluorescence of AChE as an indicator of oxime binding. Tryptophan 86-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 20412789-4 2010 Stopped-flow kinetics of oxime interaction was monitored using quenching of intrinsic tryptophan fluorescence of AChE as an indicator of oxime binding. Oximes 137-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 20417629-0 2010 Interactions of pyridinium oximes with acetylcholinesterase. pyridinium oximes 16-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 20417629-1 2010 Catalytic activity of acetylcholinesterase (AChE; EC 3.1.1.7) was studied in the presence of oximes HI-6, K114, K127 and K203, and inhibition constants were determined for the reversible enzyme-inhibitor complex (K(I)). Oximes 93-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 20417629-1 2010 Catalytic activity of acetylcholinesterase (AChE; EC 3.1.1.7) was studied in the presence of oximes HI-6, K114, K127 and K203, and inhibition constants were determined for the reversible enzyme-inhibitor complex (K(I)). Oximes 93-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 20417629-1 2010 Catalytic activity of acetylcholinesterase (AChE; EC 3.1.1.7) was studied in the presence of oximes HI-6, K114, K127 and K203, and inhibition constants were determined for the reversible enzyme-inhibitor complex (K(I)). asoxime chloride 100-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 20417629-1 2010 Catalytic activity of acetylcholinesterase (AChE; EC 3.1.1.7) was studied in the presence of oximes HI-6, K114, K127 and K203, and inhibition constants were determined for the reversible enzyme-inhibitor complex (K(I)). asoxime chloride 100-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 20417629-1 2010 Catalytic activity of acetylcholinesterase (AChE; EC 3.1.1.7) was studied in the presence of oximes HI-6, K114, K127 and K203, and inhibition constants were determined for the reversible enzyme-inhibitor complex (K(I)). K114 106-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 20417629-1 2010 Catalytic activity of acetylcholinesterase (AChE; EC 3.1.1.7) was studied in the presence of oximes HI-6, K114, K127 and K203, and inhibition constants were determined for the reversible enzyme-inhibitor complex (K(I)). K114 106-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 20417629-1 2010 Catalytic activity of acetylcholinesterase (AChE; EC 3.1.1.7) was studied in the presence of oximes HI-6, K114, K127 and K203, and inhibition constants were determined for the reversible enzyme-inhibitor complex (K(I)). 4-(Bromomethyl)phenylboronic acid 112-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 20417629-1 2010 Catalytic activity of acetylcholinesterase (AChE; EC 3.1.1.7) was studied in the presence of oximes HI-6, K114, K127 and K203, and inhibition constants were determined for the reversible enzyme-inhibitor complex (K(I)). 4-(Bromomethyl)phenylboronic acid 112-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 20417629-1 2010 Catalytic activity of acetylcholinesterase (AChE; EC 3.1.1.7) was studied in the presence of oximes HI-6, K114, K127 and K203, and inhibition constants were determined for the reversible enzyme-inhibitor complex (K(I)). 2-Methyl-5-phenylbenzothiazole 121-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 20417629-1 2010 Catalytic activity of acetylcholinesterase (AChE; EC 3.1.1.7) was studied in the presence of oximes HI-6, K114, K127 and K203, and inhibition constants were determined for the reversible enzyme-inhibitor complex (K(I)). 2-Methyl-5-phenylbenzothiazole 121-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 20417629-3 2010 Molecular modelling of AChE-oxime complexes was used to determine amino acid residues of the active site involved in the interactions. Oximes 28-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 20417629-6 2010 The weakest inhibitor, K127, also formed several hydrogen bonds with the active site residues, but due to its long linker it was more likely stabilized at the peripheral site (Tyr124), which could explain lower AChE affinity for this oxime. 4-(Bromomethyl)phenylboronic acid 23-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-215 20417629-6 2010 The weakest inhibitor, K127, also formed several hydrogen bonds with the active site residues, but due to its long linker it was more likely stabilized at the peripheral site (Tyr124), which could explain lower AChE affinity for this oxime. Oximes 234-239 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-215 20433814-13 2010 To examine directly how these differences affect oxime-mediated reactivation of AChE after inhibition by OPs, human and guinea pig red blood cell ghosts were prepared and used as sources of AChE, and the relative capacity of several different oximes to reactivate each OP-inhibited AChE were determined. Oximes 49-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 20452336-0 2010 Non-productive binding of butyryl(thio)choline in the active site of vertebrate acetylcholinesterase. Butyrylthiocholine 26-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 20452336-4 2010 However, with the hydrolysis of butyryl(thio)choline by vertebrate acetylcholinesterase, there are time-dependent and substrate-concentration-dependent decreases in catalytic activity. Butyrylthiocholine 32-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 20452337-0 2010 Galangin, a flavonol derived from Rhizoma Alpiniae Officinarum, inhibits acetylcholinesterase activity in vitro. galangin 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 20452337-0 2010 Galangin, a flavonol derived from Rhizoma Alpiniae Officinarum, inhibits acetylcholinesterase activity in vitro. 3-hydroxyflavone 12-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 20452337-2 2010 Several AChE inhibitors, e.g. rivastigmine, galantamine and huperzine are originating from plants, suggesting that herbs could potentially serve as sources for novel AChE inhibitors. Rivastigmine 30-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-12 20452337-2 2010 Several AChE inhibitors, e.g. rivastigmine, galantamine and huperzine are originating from plants, suggesting that herbs could potentially serve as sources for novel AChE inhibitors. Rivastigmine 30-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 20452337-2 2010 Several AChE inhibitors, e.g. rivastigmine, galantamine and huperzine are originating from plants, suggesting that herbs could potentially serve as sources for novel AChE inhibitors. Galantamine 44-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-12 20452337-2 2010 Several AChE inhibitors, e.g. rivastigmine, galantamine and huperzine are originating from plants, suggesting that herbs could potentially serve as sources for novel AChE inhibitors. Galantamine 44-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 20452337-2 2010 Several AChE inhibitors, e.g. rivastigmine, galantamine and huperzine are originating from plants, suggesting that herbs could potentially serve as sources for novel AChE inhibitors. huperzine A 60-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-12 20452337-2 2010 Several AChE inhibitors, e.g. rivastigmine, galantamine and huperzine are originating from plants, suggesting that herbs could potentially serve as sources for novel AChE inhibitors. huperzine A 60-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 20452337-3 2010 Here, we searched potential AChE inhibitors from flavonoids, a group of naturally occurring compounds in plants or traditional Chinese medicines (TCM). Flavonoids 49-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 20452337-4 2010 Twenty-one flavonoids, covered different subclasses, were tested for their potential function in inhibiting AChE activity from the brain in vitro. Flavonoids 11-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 20452337-6 2010 showed an inhibitory effect on AChE activity with the highest inhibition by over 55% and an IC(50) of 120 microM and an enzyme-flavonoid inhibition constant (K(i)) of 74 microM. Flavonoids 127-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 20677317-0 2010 Design, synthesis, and biological evaluation of coumarin derivatives tethered to an edrophonium-like fragment as highly potent and selective dual binding site acetylcholinesterase inhibitors. coumarin 48-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 20677317-1 2010 A large series of substituted coumarins linked through an appropriate spacer to 3-hydroxy-N,N-dimethylanilino or 3-hydroxy-N,N,N-trialkylbenzaminium moieties were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. Coumarins 30-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-212 20677317-1 2010 A large series of substituted coumarins linked through an appropriate spacer to 3-hydroxy-N,N-dimethylanilino or 3-hydroxy-N,N,N-trialkylbenzaminium moieties were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. Coumarins 30-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-218 20677317-2 2010 The highest AChE inhibitory potency in the 3-hydroxy-N,N-dimethylanilino series was observed with a 6,7-dimethoxy-3-substituted coumarin derivative, which, along with an outstanding affinity (IC(50)=0.236 nM) exhibits excellent AChE/BChE selectivity (SI>300 000). 3-hydroxy-n,n-dimethylanilino 43-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-16 20677317-2 2010 The highest AChE inhibitory potency in the 3-hydroxy-N,N-dimethylanilino series was observed with a 6,7-dimethoxy-3-substituted coumarin derivative, which, along with an outstanding affinity (IC(50)=0.236 nM) exhibits excellent AChE/BChE selectivity (SI>300 000). 3-hydroxy-n,n-dimethylanilino 43-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 228-232 20677317-2 2010 The highest AChE inhibitory potency in the 3-hydroxy-N,N-dimethylanilino series was observed with a 6,7-dimethoxy-3-substituted coumarin derivative, which, along with an outstanding affinity (IC(50)=0.236 nM) exhibits excellent AChE/BChE selectivity (SI>300 000). 6,7-dimethoxy-3 100-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-16 20677317-2 2010 The highest AChE inhibitory potency in the 3-hydroxy-N,N-dimethylanilino series was observed with a 6,7-dimethoxy-3-substituted coumarin derivative, which, along with an outstanding affinity (IC(50)=0.236 nM) exhibits excellent AChE/BChE selectivity (SI>300 000). 6,7-dimethoxy-3 100-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 228-232 20677317-2 2010 The highest AChE inhibitory potency in the 3-hydroxy-N,N-dimethylanilino series was observed with a 6,7-dimethoxy-3-substituted coumarin derivative, which, along with an outstanding affinity (IC(50)=0.236 nM) exhibits excellent AChE/BChE selectivity (SI>300 000). coumarin 128-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-16 20677317-2 2010 The highest AChE inhibitory potency in the 3-hydroxy-N,N-dimethylanilino series was observed with a 6,7-dimethoxy-3-substituted coumarin derivative, which, along with an outstanding affinity (IC(50)=0.236 nM) exhibits excellent AChE/BChE selectivity (SI>300 000). coumarin 128-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 228-232 20677317-3 2010 Most of the synthesized 3-hydroxy-N,N,N-trialkylbenzaminium salts display an AChE affinity in the sub-nanomolar to picomolar range along with excellent AChE/BChE selectivities (SI values up to 138 333). 3-hydroxy-n,n,n-trialkylbenzaminium salts 24-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 20677317-3 2010 Most of the synthesized 3-hydroxy-N,N,N-trialkylbenzaminium salts display an AChE affinity in the sub-nanomolar to picomolar range along with excellent AChE/BChE selectivities (SI values up to 138 333). 3-hydroxy-n,n,n-trialkylbenzaminium salts 24-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 20406208-2 2010 Human malathion poisoning has been treated with oximes (mainly pralidoxime) in an attempt to reactivate OP-inhibited acetylcholinesterase (AChE). Oximes 48-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 20406208-2 2010 Human malathion poisoning has been treated with oximes (mainly pralidoxime) in an attempt to reactivate OP-inhibited acetylcholinesterase (AChE). pralidoxime 63-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 20655219-0 2010 Structure-activity studies on acetylcholinesterase inhibition in the lycorine series of Amaryllidaceae alkaloids. lycorine 69-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 20655219-0 2010 Structure-activity studies on acetylcholinesterase inhibition in the lycorine series of Amaryllidaceae alkaloids. Amaryllidaceae Alkaloids 88-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 20655219-1 2010 The synthesis of differentially functionalized analogs of the Amaryllidaceae alkaloid lycorine, accessed via a concise chemoselective silylation strategy, is described uncovering two of the most potent inhibitors of acetylcholinesterase (AChE) identified to date in this series. Amaryllidaceae Alkaloids 62-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 216-236 20655219-1 2010 The synthesis of differentially functionalized analogs of the Amaryllidaceae alkaloid lycorine, accessed via a concise chemoselective silylation strategy, is described uncovering two of the most potent inhibitors of acetylcholinesterase (AChE) identified to date in this series. Amaryllidaceae Alkaloids 62-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 238-242 20655219-1 2010 The synthesis of differentially functionalized analogs of the Amaryllidaceae alkaloid lycorine, accessed via a concise chemoselective silylation strategy, is described uncovering two of the most potent inhibitors of acetylcholinesterase (AChE) identified to date in this series. lycorine 86-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 216-236 20655219-1 2010 The synthesis of differentially functionalized analogs of the Amaryllidaceae alkaloid lycorine, accessed via a concise chemoselective silylation strategy, is described uncovering two of the most potent inhibitors of acetylcholinesterase (AChE) identified to date in this series. lycorine 86-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 238-242 20823602-1 2010 A series of difunctionalized 4-hydroxybenzaldehyde derivatives were designed, synthesized and evaluated as cholinesterase (acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)) inhibitors. 4-hydroxybenzaldehyde 29-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-143 20823602-1 2010 A series of difunctionalized 4-hydroxybenzaldehyde derivatives were designed, synthesized and evaluated as cholinesterase (acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)) inhibitors. 4-hydroxybenzaldehyde 29-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 20823602-3 2010 The inhibition mechanism revealed that the best active compound 4e displayed a mix-type mode of AChE and BChE by its dual-site interactions with the catalytic triad active center and the peripheral anionic site (PAS) of enzyme. Aminosalicylic Acid 212-215 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 21034627-8 2010 Acetylcholinesterase antibody occurred more frequently in acetylcholine receptor antibody negative patients with adverse reactions to neostigmine test. Acetylcholine 58-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21034627-8 2010 Acetylcholinesterase antibody occurred more frequently in acetylcholine receptor antibody negative patients with adverse reactions to neostigmine test. Neostigmine 134-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 20664535-1 2010 The acetylcholinesterase inhibitor donepezil hydrochloride improves cognitive function in patients with Alzheimer"s disease and vascular dementia. Donepezil 35-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 20361801-5 2010 While connecting beta-carboline units by alkylene spacers in two different series of compounds and subsequent evaluation of their AChE/BChE-inhibitory potential, we found that several of these bivalent beta-carbolines were potent NR blockers. Carbolines 202-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 20945563-10 2004 [(11)C]MP4A is specifically hydrolyzed by AChE (99% specificity) and yields a hydrophilic metabolite, N-[(11)C]methylpiperidinol ([(11)C]MP4OH), which is trapped in the brain because it is too polar to cross the BBB. n-[(11)c]methylpiperidinol 102-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 20560995-4 2010 This has led to the development of drugs able to prevent acetylcholine hydrolysis (acetylcholinesterase inhibitors). Acetylcholine 57-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 21120082-14 2010 The high frequency of neurologic symptoms observed in the study may be due to parasympathetic hyperactivity due to the accumulated ACh resulting from AChE inhibition. Acetylcholine 131-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 20192902-0 2010 Oxime K027: novel low-toxic candidate for the universal reactivator of nerve agent- and pesticide-inhibited acetylcholinesterase. Oximes 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 20192902-1 2010 Oxime K027 is a low-toxic bisquaternary compound originally developed as a reactivator of acetylcholinesterase (AChE) inhibited by nerve agents. oxime k027 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 20192902-1 2010 Oxime K027 is a low-toxic bisquaternary compound originally developed as a reactivator of acetylcholinesterase (AChE) inhibited by nerve agents. oxime k027 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 20192902-3 2010 The results show that oxime K027 reactivated AChE inhibited by almost all tested inhibitors to more than 10%, which is believed to be enough for saving the lives of intoxicated organisms. oxime k027 22-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 20192902-4 2010 In the case of cyclosarin- and soman-inhibited AChE, oxime K027 did not reach sufficient reactivation potency. cyclohexyl methylphosphonofluoridate 15-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 20192902-4 2010 In the case of cyclosarin- and soman-inhibited AChE, oxime K027 did not reach sufficient reactivation potency. Soman 31-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 20192902-4 2010 In the case of cyclosarin- and soman-inhibited AChE, oxime K027 did not reach sufficient reactivation potency. oxime k027 53-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 20202777-5 2010 Oxime-type compounds used as acetylcholinesterase (AChE, E.C.3.1.1.7) reactivators have been considered for the retention study. Oximes 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 20202777-5 2010 Oxime-type compounds used as acetylcholinesterase (AChE, E.C.3.1.1.7) reactivators have been considered for the retention study. Oximes 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 20472422-0 2010 Acetylcholinesterase biosensor design based on carbon nanotube-encapsulated polypyrrole and polyaniline copolymer for amperometric detection of organophosphates. Carbon 47-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 20472422-0 2010 Acetylcholinesterase biosensor design based on carbon nanotube-encapsulated polypyrrole and polyaniline copolymer for amperometric detection of organophosphates. polypyrrole and 76-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 20472422-0 2010 Acetylcholinesterase biosensor design based on carbon nanotube-encapsulated polypyrrole and polyaniline copolymer for amperometric detection of organophosphates. polyaniline copolymer 92-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 20472422-0 2010 Acetylcholinesterase biosensor design based on carbon nanotube-encapsulated polypyrrole and polyaniline copolymer for amperometric detection of organophosphates. Organophosphates 144-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 20472422-1 2010 A simple method to immobilize acetylcholinesterase (AChE) on polypyrrole (PPy) and polyaniline (PANI) copolymer doped with multi-walled carbon nanotubes (MWCNTs) was proposed. polypyrrole 61-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 20472422-1 2010 A simple method to immobilize acetylcholinesterase (AChE) on polypyrrole (PPy) and polyaniline (PANI) copolymer doped with multi-walled carbon nanotubes (MWCNTs) was proposed. polypyrrole 61-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 20472422-1 2010 A simple method to immobilize acetylcholinesterase (AChE) on polypyrrole (PPy) and polyaniline (PANI) copolymer doped with multi-walled carbon nanotubes (MWCNTs) was proposed. polypyrrole 74-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 20472422-1 2010 A simple method to immobilize acetylcholinesterase (AChE) on polypyrrole (PPy) and polyaniline (PANI) copolymer doped with multi-walled carbon nanotubes (MWCNTs) was proposed. polypyrrole 74-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 20472422-1 2010 A simple method to immobilize acetylcholinesterase (AChE) on polypyrrole (PPy) and polyaniline (PANI) copolymer doped with multi-walled carbon nanotubes (MWCNTs) was proposed. polyaniline (pani) copolymer 83-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 20472422-1 2010 A simple method to immobilize acetylcholinesterase (AChE) on polypyrrole (PPy) and polyaniline (PANI) copolymer doped with multi-walled carbon nanotubes (MWCNTs) was proposed. polyaniline (pani) copolymer 83-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 20472422-1 2010 A simple method to immobilize acetylcholinesterase (AChE) on polypyrrole (PPy) and polyaniline (PANI) copolymer doped with multi-walled carbon nanotubes (MWCNTs) was proposed. Carbon 136-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 20472422-1 2010 A simple method to immobilize acetylcholinesterase (AChE) on polypyrrole (PPy) and polyaniline (PANI) copolymer doped with multi-walled carbon nanotubes (MWCNTs) was proposed. Carbon 136-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 20472422-3 2010 Due to the biocompatible microenvironment provided by the copolymer network, the obtained composite was devised for AChE attachment, resulting in a stable AChE biosensor for screening of organophosphates (OPs) exposure. copolymer 58-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 20472422-3 2010 Due to the biocompatible microenvironment provided by the copolymer network, the obtained composite was devised for AChE attachment, resulting in a stable AChE biosensor for screening of organophosphates (OPs) exposure. copolymer 58-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 20472422-3 2010 Due to the biocompatible microenvironment provided by the copolymer network, the obtained composite was devised for AChE attachment, resulting in a stable AChE biosensor for screening of organophosphates (OPs) exposure. Organophosphates 187-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 20472422-3 2010 Due to the biocompatible microenvironment provided by the copolymer network, the obtained composite was devised for AChE attachment, resulting in a stable AChE biosensor for screening of organophosphates (OPs) exposure. Organophosphates 187-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 20472422-3 2010 Due to the biocompatible microenvironment provided by the copolymer network, the obtained composite was devised for AChE attachment, resulting in a stable AChE biosensor for screening of organophosphates (OPs) exposure. Organophosphates 205-208 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 20472422-3 2010 Due to the biocompatible microenvironment provided by the copolymer network, the obtained composite was devised for AChE attachment, resulting in a stable AChE biosensor for screening of organophosphates (OPs) exposure. Organophosphates 205-208 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 20472422-5 2010 Based on the inhibition of OPs on the AChE activity, using malathion as a model compound, the inhibition of malathion was proportional to its concentration ranging from 0.01 to 0.5 microg/mL and from 1 to 25 microg/mL, with a detection limit of 1.0 ng/mL. Malathion 59-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 20472422-5 2010 Based on the inhibition of OPs on the AChE activity, using malathion as a model compound, the inhibition of malathion was proportional to its concentration ranging from 0.01 to 0.5 microg/mL and from 1 to 25 microg/mL, with a detection limit of 1.0 ng/mL. Malathion 108-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 20580236-0 2010 Morphinans and isoquinolines: acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors. Morphinans 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 20737911-0 2010 Acetylcholinesterase inhibitory activity of uleine from Himatanthus lancifolius. uleine 44-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 20737911-2 2010 Alkaloids, such as physostigmine, galanthamine, and huperzine A, play an important role as AChE inhibitors. Alkaloids 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 20737911-2 2010 Alkaloids, such as physostigmine, galanthamine, and huperzine A, play an important role as AChE inhibitors. Physostigmine 19-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 20737911-2 2010 Alkaloids, such as physostigmine, galanthamine, and huperzine A, play an important role as AChE inhibitors. Galantamine 34-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 20737911-2 2010 Alkaloids, such as physostigmine, galanthamine, and huperzine A, play an important role as AChE inhibitors. huperzine A 52-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 20737911-9 2010 The ethyl acetate fraction exhibited the highest level of AChE inhibition, followed by the dichloromethane fraction. ethyl acetate 4-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 20471843-0 2010 Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase. Berberine 55-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 20471843-1 2010 A series of novel berberine derivatives were designed, synthesized, and biologically evaluated as inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Berberine 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 20471843-1 2010 A series of novel berberine derivatives were designed, synthesized, and biologically evaluated as inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Berberine 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 20471843-2 2010 Among these derivatives, compound 48a, berberine linked with 3-methylpyridinium by a 2-carbon spacer, was found to be a potent inhibitor of AChE, with an IC(50) value of 0.048 microM and compound 40c, berberine linked with 2-thionaphthol by a 4-carbon spacer, acted as the most potent inhibitor for BuChE with an IC(50) value of 0.078 microM. Berberine 39-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 20471843-3 2010 Kinetic studies and molecular modeling simulations of the AChE-inhibitor complex indicated that a mixed-competitive binding mode existed for these berberine derivatives. Berberine 147-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 20472431-3 2010 The structure-activity relationship (SAR) studies identified N-benzyl-2-thiomorpholinopyrimidin-4-amine (7c) as the most potent cholinesterase inhibitor (ChEI) with an IC(50)=0.33 microM (acetylcholinesterase, AChE) and 2.30muM (butyrylcholinesterase, BuChE). CHEMBL1086014 61-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-214 20472431-3 2010 The structure-activity relationship (SAR) studies identified N-benzyl-2-thiomorpholinopyrimidin-4-amine (7c) as the most potent cholinesterase inhibitor (ChEI) with an IC(50)=0.33 microM (acetylcholinesterase, AChE) and 2.30muM (butyrylcholinesterase, BuChE). 7C 105-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-214 20472431-4 2010 The molecular modeling studies indicate that within the AChE active site, the C-2 thiomorpholine substituent was oriented toward the cationic active site region (Trp84 and Phe330) whereas within the BuChE active site, it was oriented toward a hydrophobic region closer to the active site gorge entrance (Ala277). thiamorpholine 82-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 20510904-3 2010 The inhibition of AChE activity at varying insecticide concentrations was detected with low detection limits of 10 ppb (36 nM) for paraoxon and 8 ppb (18 nM) for carbofuran. Paraoxon 131-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 20510904-3 2010 The inhibition of AChE activity at varying insecticide concentrations was detected with low detection limits of 10 ppb (36 nM) for paraoxon and 8 ppb (18 nM) for carbofuran. Carbofuran 162-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 20347021-3 2010 Reactivators (oximes) of inhibited AChE are a mainstay of treatment. Oximes 14-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 20462209-5 2010 Biological evaluation of the synthesized compounds confirmed the reported acetylcholinesterase inhibitory activity of hopeahainol A (3) but not the reported cytotoxic potencies of hopeanol (2). hopeahainol A 118-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 20452769-0 2010 Synthesis of 4-[(diethylamino)methyl]-phenol derivatives as novel cholinesterase inhibitors with selectivity towards butyrylcholinesterase. 4-[(diethylamino)methyl]-phenol 13-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-80 20452769-1 2010 A series of novel cholinesterase inhibitors, being composed of 4-[(diethylamino)methyl]-phenoxy and secondary amine which were linked with a different length alkyl chain, were designed and synthesized from the starting material p-hydroxybenzaldehyde. 4-[(diethylamino)methyl]-phenoxy and secondary amine 63-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-32 20452769-1 2010 A series of novel cholinesterase inhibitors, being composed of 4-[(diethylamino)methyl]-phenoxy and secondary amine which were linked with a different length alkyl chain, were designed and synthesized from the starting material p-hydroxybenzaldehyde. 4-hydroxybenzaldehyde 228-249 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-32 20452769-3 2010 Compounds 25-31 having a secondary amine moiety connected to the phenyl ring via eight CH(2) units spacer were found to be the most potent inhibitors with IC(50) value lower than 220nM and 48nM against AChE and BChE, respectively. Amines 35-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-206 20945563-3 2004 Acetylcholinesterase (AChE) is the enzyme that terminates cholinergic actions through the rapid hydrolysis of acetylcholine to choline and acetate. Acetylcholine 110-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 20945563-3 2004 Acetylcholinesterase (AChE) is the enzyme that terminates cholinergic actions through the rapid hydrolysis of acetylcholine to choline and acetate. Acetylcholine 110-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 20945563-3 2004 Acetylcholinesterase (AChE) is the enzyme that terminates cholinergic actions through the rapid hydrolysis of acetylcholine to choline and acetate. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 20945563-3 2004 Acetylcholinesterase (AChE) is the enzyme that terminates cholinergic actions through the rapid hydrolysis of acetylcholine to choline and acetate. Acetates 139-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 20945563-3 2004 Acetylcholinesterase (AChE) is the enzyme that terminates cholinergic actions through the rapid hydrolysis of acetylcholine to choline and acetate. Acetates 139-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 20945563-6 2004 Radiolabeled AChE inhibitors and acetylcholine analog substrates are the two major approaches to mapping AChE in vivo in the human brain. Acetylcholine 33-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 20865840-1 2010 BACKGROUND: It was found that acetylcholine concentration increased with a significantly reduced expression of acetylcholinesterase in vitiliginous patches that return to normal upon repigmentation. Acetylcholine 30-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 21133088-0 2010 Detection of organophosphate pesticide using polyaniline and carbon nanotubes composite based on acetylcholinesterase inhibition. Organophosphates 13-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 21133088-0 2010 Detection of organophosphate pesticide using polyaniline and carbon nanotubes composite based on acetylcholinesterase inhibition. polyaniline 45-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 21133088-0 2010 Detection of organophosphate pesticide using polyaniline and carbon nanotubes composite based on acetylcholinesterase inhibition. Carbon 61-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 21133088-1 2010 Acetylcholinesterase (AChE) activity may be useful biomarker for detecting of organophosphate pesticides (OP). Organophosphates 78-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 21133088-1 2010 Acetylcholinesterase (AChE) activity may be useful biomarker for detecting of organophosphate pesticides (OP). Organophosphates 78-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 21133088-4 2010 The immobilized AChE catalyzed the hydrolysis of acetylthiocholine chloride to produce thiocholine, which engendered an irreversible oxidation peak. Acetylthiocholine chloride 49-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 21133088-4 2010 The immobilized AChE catalyzed the hydrolysis of acetylthiocholine chloride to produce thiocholine, which engendered an irreversible oxidation peak. Thiocholine 55-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 21133092-4 2010 The immobilized acetylcholinesterase (AChE), as a model, showed excellent activity to its substrate and provided a quantitative measurement of organophosphate pesticide. Organophosphates 143-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 21133092-4 2010 The immobilized acetylcholinesterase (AChE), as a model, showed excellent activity to its substrate and provided a quantitative measurement of organophosphate pesticide. Organophosphates 143-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 21133188-15 2010 Pyridostigmine is the most widely used acetylcholinesterase inhibitor. Pyridostigmine Bromide 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 20542100-1 2010 OBJECTIVES: Reactivation of inhibited acetylcholinesterase (AChE) with oximes is a causal therapy of intoxication with organophosphorus compounds (OPs). Oximes 71-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 20542100-1 2010 OBJECTIVES: Reactivation of inhibited acetylcholinesterase (AChE) with oximes is a causal therapy of intoxication with organophosphorus compounds (OPs). Oximes 71-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 20542100-1 2010 OBJECTIVES: Reactivation of inhibited acetylcholinesterase (AChE) with oximes is a causal therapy of intoxication with organophosphorus compounds (OPs). Organophosphorus Compounds 119-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 20542100-1 2010 OBJECTIVES: Reactivation of inhibited acetylcholinesterase (AChE) with oximes is a causal therapy of intoxication with organophosphorus compounds (OPs). Organophosphorus Compounds 119-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 20542100-1 2010 OBJECTIVES: Reactivation of inhibited acetylcholinesterase (AChE) with oximes is a causal therapy of intoxication with organophosphorus compounds (OPs). Organophosphorus Compounds 147-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 20542100-1 2010 OBJECTIVES: Reactivation of inhibited acetylcholinesterase (AChE) with oximes is a causal therapy of intoxication with organophosphorus compounds (OPs). Organophosphorus Compounds 147-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 20546883-5 2010 The location of groups on the pyridine ring also influences passive transport into the brain; the optimum position of the oxime group was found to be position four (para) and substitution of the oxime group on the pyridine ring by carbamoyl or amidoxime group markedly decreased penetration of AChE reactivators into the CNS. pyridine 30-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 294-298 20546883-5 2010 The location of groups on the pyridine ring also influences passive transport into the brain; the optimum position of the oxime group was found to be position four (para) and substitution of the oxime group on the pyridine ring by carbamoyl or amidoxime group markedly decreased penetration of AChE reactivators into the CNS. Oximes 122-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 294-298 20600799-1 2010 A series of bis-pyridinium oximes connected by methoxy alkane linkers were synthesized and their in vitro reactivation efficacy was evaluated against sarin-inhibited human AChE, and data were compared with 2-PAM and obidoxime. bis-pyridinium oximes 12-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-176 20600799-2 2010 Among the synthesized compounds, 1,2-dimethoxy ethylene bis-[4,4"-(hydroxyiminomethyl) pyridinium] dichloride (4P-2) and 1,2-dimethoxy ethylene bis-[3,3"-(hydroxyiminomethyl) pyridinium] dichloride (3P-2) were found to be the most potent reactivators of human AChE inhibited by nerve agent sarin. 1,2-dimethoxy ethylene bis-[3,3"-(hydroxyiminomethyl) pyridinium] dichloride 121-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 260-264 20600799-6 2010 Overall, the study reveals that the oxime 4P-2 may have therapeutic potential in the reactivation of human AChE inhibited by sarin. Oximes 36-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 20466535-0 2010 Acetylcholinesterase biosensor based on Prussian blue-modified electrode for detecting organophosphorous pesticides. ferric ferrocyanide 40-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 20466535-0 2010 Acetylcholinesterase biosensor based on Prussian blue-modified electrode for detecting organophosphorous pesticides. organophosphorous 87-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 20466535-1 2010 In this study, a novel acetylcholinesterase (AChE) biosensor was developed based on dual-layer membranes (chitosan membrane and prussian blue membrane) modifying glassy carbon electrode (GCE). ferric ferrocyanide 128-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 20466535-1 2010 In this study, a novel acetylcholinesterase (AChE) biosensor was developed based on dual-layer membranes (chitosan membrane and prussian blue membrane) modifying glassy carbon electrode (GCE). ferric ferrocyanide 128-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 20466535-1 2010 In this study, a novel acetylcholinesterase (AChE) biosensor was developed based on dual-layer membranes (chitosan membrane and prussian blue membrane) modifying glassy carbon electrode (GCE). Carbon 169-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 20466535-1 2010 In this study, a novel acetylcholinesterase (AChE) biosensor was developed based on dual-layer membranes (chitosan membrane and prussian blue membrane) modifying glassy carbon electrode (GCE). Carbon 169-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 20678652-1 2010 This work describes the use of a PEDOT:PSS-based conductive polymer for designing AChE-based biosensors. Polymers 60-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 20678652-4 2010 The PEDOT:PSS polymer was shown to be suitable for thiocholine oxidation, allowing the measurement of AChE activity at 100 mV vs Ag/AgCl. Thiocholine 51-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 20678652-4 2010 The PEDOT:PSS polymer was shown to be suitable for thiocholine oxidation, allowing the measurement of AChE activity at 100 mV vs Ag/AgCl. silver chloride 132-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 21152278-0 2010 Reactivation of human acetylcholinesterase and butyrylcholinesterase inhibited by leptophos-oxon with different oxime reactivators in vitro. leptophos oxon 82-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 21152278-0 2010 Reactivation of human acetylcholinesterase and butyrylcholinesterase inhibited by leptophos-oxon with different oxime reactivators in vitro. Oximes 112-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 21152278-1 2010 We have evaluated in vitro the potency of 23 oximes to reactivate human erythrocyte acetylcholinesterase (AChE) and plasma butyrylcholinesterase (BChE) inhibited by racemic leptophos-oxon (O-[4-bromo-2,5-dichlorophenyl]-O-methyl phenyl-phosphonate), a toxic metabolite of the pesticide leptophos. Oximes 45-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 21152278-1 2010 We have evaluated in vitro the potency of 23 oximes to reactivate human erythrocyte acetylcholinesterase (AChE) and plasma butyrylcholinesterase (BChE) inhibited by racemic leptophos-oxon (O-[4-bromo-2,5-dichlorophenyl]-O-methyl phenyl-phosphonate), a toxic metabolite of the pesticide leptophos. Oximes 45-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 21152278-3 2010 In case of leptophos-oxon inhibited AChE, the best reactivation potency was achieved with methoxime, trimedoxime, obidoxime and oxime K027. leptophos oxon 11-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 21152278-3 2010 In case of leptophos-oxon inhibited AChE, the best reactivation potency was achieved with methoxime, trimedoxime, obidoxime and oxime K027. N,N'-monomethylenebis(pyridiniumaldoxime) 90-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 21152278-3 2010 In case of leptophos-oxon inhibited AChE, the best reactivation potency was achieved with methoxime, trimedoxime, obidoxime and oxime K027. Trimedoxime 101-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 21152278-3 2010 In case of leptophos-oxon inhibited AChE, the best reactivation potency was achieved with methoxime, trimedoxime, obidoxime and oxime K027. Obidoxime Chloride 114-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 21152278-3 2010 In case of leptophos-oxon inhibited AChE, the best reactivation potency was achieved with methoxime, trimedoxime, obidoxime and oxime K027. Oximes 94-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 20593080-1 2010 A bioactive paper-based colorimetric "dipstick" bioassay is reported that is based on acetylcholinesterase (AChE) catalyzed enlargement of gold nanoparticles that are co-entrapped with the enzyme in a sol-gel based silica material that is coated on a functionalized paper substrate. Silicon Dioxide 215-221 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 20593080-1 2010 A bioactive paper-based colorimetric "dipstick" bioassay is reported that is based on acetylcholinesterase (AChE) catalyzed enlargement of gold nanoparticles that are co-entrapped with the enzyme in a sol-gel based silica material that is coated on a functionalized paper substrate. Silicon Dioxide 215-221 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 20593080-3 2010 Biocatalyzed hydrolysis of ATCh via AChE leads to formation of thiocholine, which in turn reduces the Au(III) onto the entrapped nanoparticles, producing particle growth and a concomitant increase in color intensity that can be correlated to the amount of substrate or inhibitor present in test solutions. Thiocholine 63-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 20593080-3 2010 Biocatalyzed hydrolysis of ATCh via AChE leads to formation of thiocholine, which in turn reduces the Au(III) onto the entrapped nanoparticles, producing particle growth and a concomitant increase in color intensity that can be correlated to the amount of substrate or inhibitor present in test solutions. au(iii) 102-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 20550161-8 2010 In comparison with previous theoretical investigations of the AChE catalytic mechanism, our current study clearly demonstrates the power and advantages of employing Born-Oppenheimer ab initio QM/MM MD simulations in characterizing enzyme reaction mechanisms. oppenheimer 170-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 21567838-4 2010 Students carry out the computational modeling of the interaction of acetylcholinesterase and its inhibitor, tacrine, and learn about the concepts of protein structure, enzyme-inhibitor interactions, intermolecular forces, and role of molecular design in drug-development. Tacrine 108-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 20332199-4 2010 Human butyrylcholinesterase was identified as the most important esterase responsible for the enzymatic hydrolysis of aclidinium from inhibition studies in human plasma with selective paraoxonase, arylesterase, carboxylesterase, acetylcholinesterase, and butyrylcholinesterase chemical inhibitors, as well as from incubations with pure human cholinesterases. aclidinium bromide 118-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 229-249 20332199-7 2010 Aclidinium was shown to inhibit competitively both human butyrylcholinesterase (K(i), 2.7 microM) and acetylcholinesterase (6.3 microM) but did not have any effect on the activity of other human esterases, as well as its hydrolysis metabolites. aclidinium bromide 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 21787634-0 2010 Reactivation of VX-inhibited AChE by novel oximes having two oxygen atoms in the linker. Oximes 43-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 21787634-0 2010 Reactivation of VX-inhibited AChE by novel oximes having two oxygen atoms in the linker. Oxygen 61-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 21787634-1 2010 Two newly developed AChE reactivators possessing two oxime groups in 4-position of the pyridinium rings with linkers CH(2)O(CH(2))(2)OCH(2) and CH(2)O(CH(2))(4)OCH(2) were tested for their potency to reactivate VX-inhibited AChE. Oximes 53-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 21787634-1 2010 Two newly developed AChE reactivators possessing two oxime groups in 4-position of the pyridinium rings with linkers CH(2)O(CH(2))(2)OCH(2) and CH(2)O(CH(2))(4)OCH(2) were tested for their potency to reactivate VX-inhibited AChE. pyridine 87-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 20929049-5 2010 Although new oximes that can reactivate both peripheral and cerebral AChE and other prophylactic agents such as human serum butyrylcholinesterase (Hu BChE), sodium bicarbonate, huperzine A (a reversible ChE inhibitor) with imidazenil (a GABAA receptor modulator) have been proved effective in animal models, systematic clinical trials in patients are warranted. Oximes 13-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 19969445-0 2010 Effect of isoquinoline alkaloids from two Hippeastrum species on in vitro acetylcholinesterase activity. isoquinoline alkaloids 10-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 19969445-1 2010 The treatment of neurological disorders and neurodegenerative diseases is related to the levels of acetylcholine (ACh) through the inhibition of acetylcholinesterase (AChE). Acetylcholine 99-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 19969445-1 2010 The treatment of neurological disorders and neurodegenerative diseases is related to the levels of acetylcholine (ACh) through the inhibition of acetylcholinesterase (AChE). Acetylcholine 99-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 19969445-1 2010 The treatment of neurological disorders and neurodegenerative diseases is related to the levels of acetylcholine (ACh) through the inhibition of acetylcholinesterase (AChE). Acetylcholine 114-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 19969445-1 2010 The treatment of neurological disorders and neurodegenerative diseases is related to the levels of acetylcholine (ACh) through the inhibition of acetylcholinesterase (AChE). Acetylcholine 114-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 19969445-2 2010 Galanthamine, an important alkaloid isolated from the Amaryllidaceae family, is approved for the pharmacological treatment of Alzheimer"s disease (AD) and acts by inhibiting the acetylcholinesterase (AChE) activity. Galantamine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-198 19969445-2 2010 Galanthamine, an important alkaloid isolated from the Amaryllidaceae family, is approved for the pharmacological treatment of Alzheimer"s disease (AD) and acts by inhibiting the acetylcholinesterase (AChE) activity. Galantamine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-204 19969445-3 2010 In the present study, Ellman"s method was used to verify the inhibition of AChE activity of some isoquinolines alkaloids such as galanthamine, montanine, hippeastrine and pretazettine. isoquinolines alkaloids 97-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 19969445-3 2010 In the present study, Ellman"s method was used to verify the inhibition of AChE activity of some isoquinolines alkaloids such as galanthamine, montanine, hippeastrine and pretazettine. Galantamine 129-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 19969445-3 2010 In the present study, Ellman"s method was used to verify the inhibition of AChE activity of some isoquinolines alkaloids such as galanthamine, montanine, hippeastrine and pretazettine. montanine 143-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 19969445-3 2010 In the present study, Ellman"s method was used to verify the inhibition of AChE activity of some isoquinolines alkaloids such as galanthamine, montanine, hippeastrine and pretazettine. hippeastrine 154-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 19969445-3 2010 In the present study, Ellman"s method was used to verify the inhibition of AChE activity of some isoquinolines alkaloids such as galanthamine, montanine, hippeastrine and pretazettine. pretazettine 171-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 19969445-4 2010 At the concentrations 1mM, 500 microm and 100 microm, galanthamine presented an AChE inhibition higher than 90%. Galantamine 54-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 19969445-8 2010 The results demonstrate that montanine significantly inhibits AChE activity at the tested concentrations, suggesting the necessity of further investigations on this alkaloid use in treating neurological disorders. montanine 29-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 20059698-2 2010 BACKGROUND: Acotiamide is a selective acetylcholinesterase inhibitor and enhances the actions of cholinergic neurons localized in the stomach. Z 338 12-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 20193764-2 2010 Of known interventions, psychopharmacology provides readily available options, such as the anti-dementia drugs, e.g. acetylcholinesterase inhibitors (donepezil, galantamine, rivastigmine) and memantine. Donepezil 150-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 20193764-2 2010 Of known interventions, psychopharmacology provides readily available options, such as the anti-dementia drugs, e.g. acetylcholinesterase inhibitors (donepezil, galantamine, rivastigmine) and memantine. Galantamine 161-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 20193764-2 2010 Of known interventions, psychopharmacology provides readily available options, such as the anti-dementia drugs, e.g. acetylcholinesterase inhibitors (donepezil, galantamine, rivastigmine) and memantine. Rivastigmine 174-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 20562785-2 2010 She was diagnosed with non-familial early-onset Alzheimer"s Disease (EOAD) and started on 8mg daily of the acetylcholinesterase inhibitor Galantamine. Galantamine 138-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 20370537-1 2010 Reactivation efficacy of three homologous and three isomeric series of pralidoxime-type reactivators with aldoxime group in position 2, 3 and 4 of the heterocycle was tested in reactivation of tabun-inhibited AChE. pralidoxime 71-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-213 20370537-1 2010 Reactivation efficacy of three homologous and three isomeric series of pralidoxime-type reactivators with aldoxime group in position 2, 3 and 4 of the heterocycle was tested in reactivation of tabun-inhibited AChE. acetaldehyde oxime 106-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-213 20408548-1 2010 Tabun is a warfare agent that inhibits human acetylcholinesterase (hAChE) by rapid phosphylation of the catalytic serine. tabun 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-72 20408548-1 2010 Tabun is a warfare agent that inhibits human acetylcholinesterase (hAChE) by rapid phosphylation of the catalytic serine. Serine 114-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-72 20439843-3 2010 METHODS: We used PET with [(11)C]PMP to measure acetylcholinesterase (AChE) activity in multiple cerebral cortical and subcortical regions. 2-(4-methoxyphenoxy)propanoic acid 33-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 20156534-0 2010 Comparative study of oxime-induced reactivation of erythrocyte and muscle AChE from different animal species following inhibition by sarin or paraoxon. Oximes 21-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 20156534-1 2010 Standard treatment of acute poisoning by organophosphorus compounds (OP) includes administration of an antimuscarinic (e.g. atropine) and of an oxime-based reactivator of OP-inhibited acetylcholinesterase (AChE). Organophosphorus Compounds 41-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 206-210 20156534-1 2010 Standard treatment of acute poisoning by organophosphorus compounds (OP) includes administration of an antimuscarinic (e.g. atropine) and of an oxime-based reactivator of OP-inhibited acetylcholinesterase (AChE). Oximes 144-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 206-210 20156534-2 2010 A recently introduced dynamically working in vitro model with real-time determination of membrane-bound AChE activity was shown to be a very versatile and promising model to investigate oxime-induced reactivation kinetics of OP-inhibited enzyme. Oximes 186-191 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 20156534-6 2010 In addition, the basic kinetic constants of inhibition, aging, spontaneous- and oxime-induced-reactivation of erythrocyte AChE from these species were determined with a standard static model. Oximes 80-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 20361801-6 2010 The most promising compound was a N(9)-homobivalent beta-carboline with a nonylene spacer, which displayed IC(50) values of 0.5 nM for AChE, 5.7 nM for BChE, and 1.4 microM for NR, respectively. norharman 52-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 20361801-6 2010 The most promising compound was a N(9)-homobivalent beta-carboline with a nonylene spacer, which displayed IC(50) values of 0.5 nM for AChE, 5.7 nM for BChE, and 1.4 microM for NR, respectively. 1-NONENE 74-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 20188972-3 2010 The principle of the assay is based on enzymatic hydrolysis of acetylcholine into acetic acid and choline by acetylcholinesterase. Acetylcholine 63-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-129 20347302-2 2010 The most potent AChEIs disclosed contain an aromatic alkyl-aryl linker between an NSAID and a lipophilic choline mimic and they inhibit acetylcholinesterase (AChE) in the submicromolar range. Choline 105-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 20188890-2 2010 Coumaphos is a phosphotionate insecticide requiring transformation in the corresponding oxo-form to act as an effective AChE inhibitor. Coumaphos 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 20188890-3 2010 The inhibition assay was based on the electrochemical detection of the product of AChE, choline, via a choline oxidase biosensors obtained using prussian-blue modified screen printed electrodes. Choline 88-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 20188890-4 2010 A simple procedure for the oxidation of coumaphos via N-bromosuccinimide (NBS) and AChE inhibition was optimised. Coumaphos 40-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 20447848-1 2010 Acetylcholinesterase (AChE) plays a crucial role in nerve impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine (ACh). Acetylcholine 147-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 20447848-1 2010 Acetylcholinesterase (AChE) plays a crucial role in nerve impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine (ACh). Acetylcholine 147-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 20447848-1 2010 Acetylcholinesterase (AChE) plays a crucial role in nerve impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine (ACh). Acetylcholine 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 20447848-2 2010 AChE has become an important drug target because partial inhibition of AChE results in modest increase in ACh levels that can have therapeutic benefits, thus AChE inhibitors have proved useful in the symptomatic treatment of Alzheimer"s disease. Acetylcholine 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 20447848-2 2010 AChE has become an important drug target because partial inhibition of AChE results in modest increase in ACh levels that can have therapeutic benefits, thus AChE inhibitors have proved useful in the symptomatic treatment of Alzheimer"s disease. Acetylcholine 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 20147288-5 2010 In NG108-15 neuroblastoma cells transfected with cDNAs encoding AChE(T) and PRiMA, PRiMA-linked G(4) AChE was found in membrane rafts and showed the same sensitivity to cold Triton X-100 extraction as in the brain. Octoxynol 174-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 20147288-8 2010 The cytoplasmic domain of PRiMA, which differs between PRiMA I and PRiMA II, appeared to play some role in stabilizing the raft localization of G(4) AChE, because the Triton X-100-resistant fraction was smaller with the shorter PRiMA II isoform than that with the longer PRiMA I isoform. Octoxynol 167-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 20401964-0 2010 Use of a novel radiometric method to assess the inhibitory effect of donepezil on acetylcholinesterase activity in minimally diluted tissue samples. Donepezil 69-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 20401964-9 2010 The IC(50) values of specific AChE and BChE inhibitors, donepezil and ethopropazine, in 1.2-fold diluted human whole blood were much higher than those in 120-fold diluted blood. Donepezil 56-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 20401964-9 2010 The IC(50) values of specific AChE and BChE inhibitors, donepezil and ethopropazine, in 1.2-fold diluted human whole blood were much higher than those in 120-fold diluted blood. profenamine 70-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 20079560-0 2010 Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors. rutecarpine 34-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 20079560-0 2010 Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors. Alkaloids 71-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 19962381-0 2010 Donepezil, an acetylcholinesterase inhibitor against Alzheimer"s dementia, promotes angiogenesis in an ischemic hindlimb model. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 19962381-3 2010 Therefore, we assessed the hypothesis that the cholinergic modulator donepezil, an acetylcholinesterase inhibitor utilized in Alzheimer"s disease, exhibits beneficial effects, especially on the acceleration of angiogenesis. Donepezil 69-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 20352203-4 2010 The widespread expression of nonneuronal acetylcholine is accompanied by the ubiquitous presence of acetylcholinesterase and nicotinic/muscarinic receptors. Acetylcholine 41-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 20096330-1 2010 The main action of organophosphorous insecticides is generally believed to be the inhibition of acetylcholinesterase (AChE). organophosphorous 19-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 20096330-1 2010 The main action of organophosphorous insecticides is generally believed to be the inhibition of acetylcholinesterase (AChE). organophosphorous 19-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 20196555-4 2010 In vitro tests on AChE showed that one of those compounds presented a very good inhibition activity, of the same order as Donepezil. Donepezil 122-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 19899797-2 2010 As a model system, immobilization of acetylcholinesterase (AChE) was investigated using biomagnetic glasses composed of a magnetic core with a size tunable porous silica shell. Silicon Dioxide 163-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 19899797-2 2010 As a model system, immobilization of acetylcholinesterase (AChE) was investigated using biomagnetic glasses composed of a magnetic core with a size tunable porous silica shell. Silicon Dioxide 163-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 20176490-1 2010 Inhibition of acetylcholinesterase (AChE) and therefore prevention of acetylcholine degradation is one of the most accepted therapy opportunities for Alzheimer s disease (AD), today. Acetylcholine 14-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 20189400-0 2010 Synthesis and kinetic analysis of some phosphonate analogs of cyclophostin as inhibitors of human acetylcholinesterase. Organophosphonates 39-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-118 20189400-0 2010 Synthesis and kinetic analysis of some phosphonate analogs of cyclophostin as inhibitors of human acetylcholinesterase. cyclophostin 62-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-118 20189400-2 2010 The potencies and mechanisms of inhibition of the bicyclic and monocyclic enol phosphonates and the exocyclic enol phosphates toward human AChE are examined. bicyclic and 50-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 20189400-2 2010 The potencies and mechanisms of inhibition of the bicyclic and monocyclic enol phosphonates and the exocyclic enol phosphates toward human AChE are examined. exocyclic enol phosphates 100-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 20143889-4 2010 Acetylcholinesterase was used as the labeling enzyme to convert acetylthiocholine to thiocholine. Acetylthiocholine 64-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 20143889-4 2010 Acetylcholinesterase was used as the labeling enzyme to convert acetylthiocholine to thiocholine. Thiocholine 70-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 20188972-3 2010 The principle of the assay is based on enzymatic hydrolysis of acetylcholine into acetic acid and choline by acetylcholinesterase. Acetic Acid 82-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-129 20188972-3 2010 The principle of the assay is based on enzymatic hydrolysis of acetylcholine into acetic acid and choline by acetylcholinesterase. Choline 69-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-129 20188972-6 2010 Presence of an organophosphate pesticide or a nerve agent results in irreversible inhibition of acetylcholinesterase intercepted on the dipstick. Organophosphates 15-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 19957265-0 2010 Circadian variation in salivary testosterone across age classes in Ache Amerindian males of Paraguay. Testosterone 32-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 19957265-4 2010 Because many nonindustrialized populations, such as Ache Amerindians of Paraguay, exhibit testosterone levels that are lower than what is commonly reported in the clinical literature and lack age-associated variation in testosterone, it was hypothesized that Ache men would not show age-related variation in testosterone circadian rhythms. Testosterone 90-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 19957265-4 2010 Because many nonindustrialized populations, such as Ache Amerindians of Paraguay, exhibit testosterone levels that are lower than what is commonly reported in the clinical literature and lack age-associated variation in testosterone, it was hypothesized that Ache men would not show age-related variation in testosterone circadian rhythms. Testosterone 90-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 259-263 19957265-4 2010 Because many nonindustrialized populations, such as Ache Amerindians of Paraguay, exhibit testosterone levels that are lower than what is commonly reported in the clinical literature and lack age-associated variation in testosterone, it was hypothesized that Ache men would not show age-related variation in testosterone circadian rhythms. Testosterone 220-232 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 19957265-4 2010 Because many nonindustrialized populations, such as Ache Amerindians of Paraguay, exhibit testosterone levels that are lower than what is commonly reported in the clinical literature and lack age-associated variation in testosterone, it was hypothesized that Ache men would not show age-related variation in testosterone circadian rhythms. Testosterone 220-232 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 20144867-2 2010 Most of them showed potent inhibition activities against AChE, in which compound 17 especially exhibited significantly higher selectivity over BChE than phenserine, a compound currently on clinical trial. phenserine 153-163 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 20149667-5 2010 In contrast to DUO3 the new bisphenyl-substituted pyridinylidene hydrazones 5 are appropriate to cross the blood-brain barrier due to their pK(a) values and lipophilicity, and to inhibit both the AChE and BuChE. bisphenyl-substituted pyridinylidene hydrazones 28-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 196-200 20531478-1 2010 The effect of electrostatic interactions on the absorption of the positively charged reversible inhibitor tetramethylammonium, its neutral structural analogue neopentane C(CH(3))(4), and the natural substrate acethylcholine to the active sites of acetylcholinesterase and butyrylcholinesterase has been studied by molecular modeling methods. tetramethylammonium 106-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 247-267 20531478-1 2010 The effect of electrostatic interactions on the absorption of the positively charged reversible inhibitor tetramethylammonium, its neutral structural analogue neopentane C(CH(3))(4), and the natural substrate acethylcholine to the active sites of acetylcholinesterase and butyrylcholinesterase has been studied by molecular modeling methods. neopentane c 159-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 247-267 20190429-4 2010 Such dual inhibitors were designed by the hybridization of rivastigmine and fluoxetine based on a hypothetical model of the AChE active site. Rivastigmine 59-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 20531478-1 2010 The effect of electrostatic interactions on the absorption of the positively charged reversible inhibitor tetramethylammonium, its neutral structural analogue neopentane C(CH(3))(4), and the natural substrate acethylcholine to the active sites of acetylcholinesterase and butyrylcholinesterase has been studied by molecular modeling methods. acethylcholine 209-223 acetylcholinesterase (Cartwright blood group) Homo sapiens 247-267 20190429-4 2010 Such dual inhibitors were designed by the hybridization of rivastigmine and fluoxetine based on a hypothetical model of the AChE active site. Fluoxetine 76-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 19935404-0 2010 Estimation of plasma IC50 of donepezil for cerebral acetylcholinesterase inhibition in patients with Alzheimer disease using positron emission tomography. Donepezil 29-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 19935404-1 2010 OBJECTIVES: Estimate the value of in vivo plasma IC50 of donepezil, the concentration of donepezil in plasma that inhibits brain acetylcholinesterase (AChE) activity by 50% at the steady-state conditions of donepezil between the plasma and the brain. Donepezil 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-149 19935404-1 2010 OBJECTIVES: Estimate the value of in vivo plasma IC50 of donepezil, the concentration of donepezil in plasma that inhibits brain acetylcholinesterase (AChE) activity by 50% at the steady-state conditions of donepezil between the plasma and the brain. Donepezil 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 19935404-3 2010 The plasma IC50 value of donepezil was estimated from plasma donepezil concentrations and cerebral cortical mean AChE inhibition rates measured by positron emission tomography, using one-parameter model. Donepezil 25-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 19935404-4 2010 RESULTS: Donepezil reduced AChE activity uniformly in the cerebral cortex compared with the baseline in each AD patient, and the mean reduction rate in the cerebral cortex was 34.6%. Donepezil 9-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 19935404-7 2010 CONCLUSIONS: Once the plasma IC50 of donepezil is determined, the brain AChE inhibition rate could be estimated from the plasma concentration of donepezil in each subject based on the plasma IC50. Donepezil 37-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 19935404-7 2010 CONCLUSIONS: Once the plasma IC50 of donepezil is determined, the brain AChE inhibition rate could be estimated from the plasma concentration of donepezil in each subject based on the plasma IC50. Donepezil 145-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 19650071-9 2010 Subsequently, HSMD was applied to mobile loops of the enzymes porcine pancreatic alpha-amylase and acetylcholinesterase in explicit water, where the difference in F between the bound and free states of the loop was calculated. Water 132-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 19935404-1 2010 OBJECTIVES: Estimate the value of in vivo plasma IC50 of donepezil, the concentration of donepezil in plasma that inhibits brain acetylcholinesterase (AChE) activity by 50% at the steady-state conditions of donepezil between the plasma and the brain. Donepezil 57-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-149 19935404-1 2010 OBJECTIVES: Estimate the value of in vivo plasma IC50 of donepezil, the concentration of donepezil in plasma that inhibits brain acetylcholinesterase (AChE) activity by 50% at the steady-state conditions of donepezil between the plasma and the brain. Donepezil 57-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 19935404-1 2010 OBJECTIVES: Estimate the value of in vivo plasma IC50 of donepezil, the concentration of donepezil in plasma that inhibits brain acetylcholinesterase (AChE) activity by 50% at the steady-state conditions of donepezil between the plasma and the brain. Donepezil 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-149 19935404-1 2010 OBJECTIVES: Estimate the value of in vivo plasma IC50 of donepezil, the concentration of donepezil in plasma that inhibits brain acetylcholinesterase (AChE) activity by 50% at the steady-state conditions of donepezil between the plasma and the brain. Donepezil 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 19948211-3 2010 Dose-dependent AChE and Na(+)/K(+)-ATPase inhibition by diazinon was obtained for all investigated cells. Diazinon 56-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 21120165-2 2010 Neostigmine, an acetylcholinesterase inhibitor, has been used in patients in whom supportive therapy failed to resolve ACPO. Neostigmine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 20138518-1 2010 Reversible inhibitors (e.g., pyridostigmine bromide, neostigmine bromide) of carbamate origin are used in the early treatment of Myasthenia gravis (MG) to block acetylcholinesterase (AChE) native function and conserve efficient amount of acetylcholine for decreasing number of nicotinic receptors. Pyridostigmine Bromide 29-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-181 20138518-1 2010 Reversible inhibitors (e.g., pyridostigmine bromide, neostigmine bromide) of carbamate origin are used in the early treatment of Myasthenia gravis (MG) to block acetylcholinesterase (AChE) native function and conserve efficient amount of acetylcholine for decreasing number of nicotinic receptors. Pyridostigmine Bromide 29-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-187 20138518-1 2010 Reversible inhibitors (e.g., pyridostigmine bromide, neostigmine bromide) of carbamate origin are used in the early treatment of Myasthenia gravis (MG) to block acetylcholinesterase (AChE) native function and conserve efficient amount of acetylcholine for decreasing number of nicotinic receptors. Neostigmine 53-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-181 20138518-1 2010 Reversible inhibitors (e.g., pyridostigmine bromide, neostigmine bromide) of carbamate origin are used in the early treatment of Myasthenia gravis (MG) to block acetylcholinesterase (AChE) native function and conserve efficient amount of acetylcholine for decreasing number of nicotinic receptors. Neostigmine 53-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-187 20138518-1 2010 Reversible inhibitors (e.g., pyridostigmine bromide, neostigmine bromide) of carbamate origin are used in the early treatment of Myasthenia gravis (MG) to block acetylcholinesterase (AChE) native function and conserve efficient amount of acetylcholine for decreasing number of nicotinic receptors. Carbamates 77-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-181 20138518-1 2010 Reversible inhibitors (e.g., pyridostigmine bromide, neostigmine bromide) of carbamate origin are used in the early treatment of Myasthenia gravis (MG) to block acetylcholinesterase (AChE) native function and conserve efficient amount of acetylcholine for decreasing number of nicotinic receptors. Carbamates 77-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-187 20138518-1 2010 Reversible inhibitors (e.g., pyridostigmine bromide, neostigmine bromide) of carbamate origin are used in the early treatment of Myasthenia gravis (MG) to block acetylcholinesterase (AChE) native function and conserve efficient amount of acetylcholine for decreasing number of nicotinic receptors. Acetylcholine 161-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-187 20138518-2 2010 Carbamate inhibitors are known for many undesirable side effects related to the reversible inhibition of AChE. Carbamates 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 19948211-5 2010 Results obtained for reference commercially purified target enzymes indicate similar sensitivity of AChE towards diazinon (IC(50) (20 min)-7.8x10(-5)M), while diazinon concentrations below 10mM did not noticeably affect Na(+)/K(+)-ATPase activity. Diazinon 113-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 20026393-1 2010 Acetylcholinesterase and butyrylcholinesterase (BChE) activities in blood are widely used as the biomarkers for organophosphorus insecticide (OP) exposure. organophosphorus 112-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 20113735-0 2010 AChE biosensor based on zinc oxide sol-gel for the detection of pesticides. Zinc Oxide 24-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 20113735-1 2010 Zinc oxide has been used as a matrix for immobilization of acetylcholinesterase (AChE) and detection of the pesticide paraoxon. Zinc Oxide 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 20113735-1 2010 Zinc oxide has been used as a matrix for immobilization of acetylcholinesterase (AChE) and detection of the pesticide paraoxon. Zinc Oxide 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 20113735-3 2010 The biosensor detected paraoxon in the range 0.035-1.38 ppm and can be used to detect other AChE inhibiting organophosphate pesticides. Paraoxon 23-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 20113735-3 2010 The biosensor detected paraoxon in the range 0.035-1.38 ppm and can be used to detect other AChE inhibiting organophosphate pesticides. Organophosphates 108-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 20004171-6 2010 OP-inhibited butyrylcholinesterase and acetylcholinesterase can be reactivated with oximes provided the OP has not aged. Oximes 84-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 20047331-2 2010 On the basis of their extended CB(1) antagonist pharmacophore, hybrid molecules exhibiting cannabinoid CB(1) receptor antagonistic as well as acetylcholinesterase (AChE) inhibiting activities were designed. cb(1) 31-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 20047331-2 2010 On the basis of their extended CB(1) antagonist pharmacophore, hybrid molecules exhibiting cannabinoid CB(1) receptor antagonistic as well as acetylcholinesterase (AChE) inhibiting activities were designed. cb(1) 31-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 20047331-4 2010 The imidazole-based 20 showed high CB(1) receptor affinity (48 nM) in combination with high CB(1)/CB(2) receptor subtype selectivity (>20-fold) and elicited equipotent AChE inhibitory activity as 1. imidazole 4-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 20047331-5 2010 Molecular modeling studies revealed the presence of a binding pocket in the AChE enzyme which nicely accommodates the CB(1) pharmacophores of the target compounds 12, 13, 20, and 21. cb(1) 118-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 20103101-3 2010 A bienzyme system containing co-immobilized acetylcholinesterase and choline oxidase was used for the evaluation of enzyme inhibition induced by malaoxon, eserine and methomyl analytes. malaoxon 145-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 19733130-1 2010 In this paper, an acetylcholinesterase (AChE)/dendrimers polyamidoamine (PAMAM)-Au/Carbon nanotubes (CNTs) multilayer modified electrode based on LbL self-assembled technique was employed in the detection of carbofuran in samples. Poly(amidoamine) 57-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 19733130-1 2010 In this paper, an acetylcholinesterase (AChE)/dendrimers polyamidoamine (PAMAM)-Au/Carbon nanotubes (CNTs) multilayer modified electrode based on LbL self-assembled technique was employed in the detection of carbofuran in samples. Poly(amidoamine) 57-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 19733130-1 2010 In this paper, an acetylcholinesterase (AChE)/dendrimers polyamidoamine (PAMAM)-Au/Carbon nanotubes (CNTs) multilayer modified electrode based on LbL self-assembled technique was employed in the detection of carbofuran in samples. Poly(amidoamine) 73-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 19733130-1 2010 In this paper, an acetylcholinesterase (AChE)/dendrimers polyamidoamine (PAMAM)-Au/Carbon nanotubes (CNTs) multilayer modified electrode based on LbL self-assembled technique was employed in the detection of carbofuran in samples. Poly(amidoamine) 73-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 19733130-1 2010 In this paper, an acetylcholinesterase (AChE)/dendrimers polyamidoamine (PAMAM)-Au/Carbon nanotubes (CNTs) multilayer modified electrode based on LbL self-assembled technique was employed in the detection of carbofuran in samples. Gold 80-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 19733130-1 2010 In this paper, an acetylcholinesterase (AChE)/dendrimers polyamidoamine (PAMAM)-Au/Carbon nanotubes (CNTs) multilayer modified electrode based on LbL self-assembled technique was employed in the detection of carbofuran in samples. Gold 80-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 19733130-1 2010 In this paper, an acetylcholinesterase (AChE)/dendrimers polyamidoamine (PAMAM)-Au/Carbon nanotubes (CNTs) multilayer modified electrode based on LbL self-assembled technique was employed in the detection of carbofuran in samples. Carbon 83-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 19733130-1 2010 In this paper, an acetylcholinesterase (AChE)/dendrimers polyamidoamine (PAMAM)-Au/Carbon nanotubes (CNTs) multilayer modified electrode based on LbL self-assembled technique was employed in the detection of carbofuran in samples. Carbon 83-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 19733130-1 2010 In this paper, an acetylcholinesterase (AChE)/dendrimers polyamidoamine (PAMAM)-Au/Carbon nanotubes (CNTs) multilayer modified electrode based on LbL self-assembled technique was employed in the detection of carbofuran in samples. Carbofuran 208-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 19733130-1 2010 In this paper, an acetylcholinesterase (AChE)/dendrimers polyamidoamine (PAMAM)-Au/Carbon nanotubes (CNTs) multilayer modified electrode based on LbL self-assembled technique was employed in the detection of carbofuran in samples. Carbofuran 208-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 20056426-0 2010 Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors. Berberine 60-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 20056426-1 2010 By targeting the dual active sites of acetylcholinesterase (AChE), a new series of berberine derivatives was designed, synthesized, and evaluated as AChE inhibitors. Berberine 83-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 20056426-1 2010 By targeting the dual active sites of acetylcholinesterase (AChE), a new series of berberine derivatives was designed, synthesized, and evaluated as AChE inhibitors. Berberine 83-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 20056426-1 2010 By targeting the dual active sites of acetylcholinesterase (AChE), a new series of berberine derivatives was designed, synthesized, and evaluated as AChE inhibitors. Berberine 83-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 20056426-3 2010 Compound 8c, berberine linked with phenol by a 4-carbon spacer, showed the most potent inhibition of AChE. Berberine 13-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 20056426-3 2010 Compound 8c, berberine linked with phenol by a 4-carbon spacer, showed the most potent inhibition of AChE. Phenol 35-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 20056426-3 2010 Compound 8c, berberine linked with phenol by a 4-carbon spacer, showed the most potent inhibition of AChE. Carbon 49-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 20056426-4 2010 A kinetic study of AChE and BuChE indicated that a mix-competitive binding mode existed for these berberine derivatives. Berberine 98-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 20056426-5 2010 Molecular modeling studies confirmed that these hybrids target both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. Aminosalicylic Acid 133-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 20056426-6 2010 This is the first report where AChE inhibitory activity has been associated with berberine as a lead molecule. Berberine 81-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 20061157-3 2010 Simple substituent variation on aroyl moiety changes anti-AChE activity for two orders of magnitude; also substitution and type of hetero(ali)cycle in position 2 of butanoic moiety govern AChE/BChE selectivity. butanoic 165-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 20061157-3 2010 Simple substituent variation on aroyl moiety changes anti-AChE activity for two orders of magnitude; also substitution and type of hetero(ali)cycle in position 2 of butanoic moiety govern AChE/BChE selectivity. butanoic 165-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-192 20084332-1 2010 The cardiovascular electrophysiologic basis for the action of pyridostigmine, an acetylcholinesterase inhibitor, has not been investigated. Pyridostigmine Bromide 62-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 20058292-0 2010 Monooxime-monocarbamoyl Bispyridinium Xylene-Linked Reactivators of Acetylcholinesterase-Synthesis, In vitro and Toxicity Evaluation, and Docking Studies. monooxime 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 20058292-0 2010 Monooxime-monocarbamoyl Bispyridinium Xylene-Linked Reactivators of Acetylcholinesterase-Synthesis, In vitro and Toxicity Evaluation, and Docking Studies. monocarbamoyl bispyridinium xylene 10-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 20058292-1 2010 Acetylcholinesterase (AChE) reactivators are crucial antidotes to organophosphate intoxication. Organophosphates 66-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 20058292-1 2010 Acetylcholinesterase (AChE) reactivators are crucial antidotes to organophosphate intoxication. Organophosphates 66-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 19496158-0 2010 Synthesis of enantiomers of exo-2-norbornyl-N-n-butylcarbamate and endo-2-norbornyl-N-n-butylcarbamate for stereoselective inhibition of acetylcholinesterase. exo-2-norbornyl-n-n-butylcarbamate 28-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 19496158-0 2010 Synthesis of enantiomers of exo-2-norbornyl-N-n-butylcarbamate and endo-2-norbornyl-N-n-butylcarbamate for stereoselective inhibition of acetylcholinesterase. endo-2-norbornyl-n-n-butylcarbamate 67-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 19496158-1 2010 The acetylcholinesterase inhibition by enantiomers of exo- and endo-2-norbornyl-N-n-butylcarbamates shows high stereoselelectivity. -norbornyl-n-n-butylcarbamates 69-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 19496158-2 2010 For the acetylcholinesterase inhibitions by (R)-(+)- and (S)-(-)-exo-2-norbornyl-N-n-butylcarbamates, the R-enantiomer is more potent than the S-enantiomer. (r)-(+)- 44-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-28 19496158-2 2010 For the acetylcholinesterase inhibitions by (R)-(+)- and (S)-(-)-exo-2-norbornyl-N-n-butylcarbamates, the R-enantiomer is more potent than the S-enantiomer. (s)-(-)-exo-2-norbornyl-n-n-butylcarbamates 57-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-28 19496158-3 2010 But, for the acetylcholinesterase inhibitions by (R)-(+)- and (S)-(-)-endo-2-norbornyl-N-n-butylcarbamates, the S-enantiomer is more potent than the R-enantiomer. (r)-(+)- 49-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-33 19496158-3 2010 But, for the acetylcholinesterase inhibitions by (R)-(+)- and (S)-(-)-endo-2-norbornyl-N-n-butylcarbamates, the S-enantiomer is more potent than the R-enantiomer. (s)-(-)-endo-2-norbornyl-n-n-butylcarbamates 62-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-33 19836169-1 2010 Acetylcholinesterase (AChE) inhibitors increase synaptic levels of acetylcholine (ACh) by inhibiting its breakdown. Acetylcholine 67-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 19836169-1 2010 Acetylcholinesterase (AChE) inhibitors increase synaptic levels of acetylcholine (ACh) by inhibiting its breakdown. Acetylcholine 67-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 19836169-1 2010 Acetylcholinesterase (AChE) inhibitors increase synaptic levels of acetylcholine (ACh) by inhibiting its breakdown. Acetylcholine 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 19836169-2 2010 Donepezil is a reversible AChE inhibitor that is clinically available and relatively selective for inhibiting AChE but not other cholinesterases. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 19836169-2 2010 Donepezil is a reversible AChE inhibitor that is clinically available and relatively selective for inhibiting AChE but not other cholinesterases. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 19836169-3 2010 Because AChE inhibitors have been shown to decrease the reinforcing effects of cocaine in animals, our hypothesis was that pretreatment with donepezil would attenuate the perceived value and other positive subjective effects of cocaine. Cocaine 79-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-12 19836169-3 2010 Because AChE inhibitors have been shown to decrease the reinforcing effects of cocaine in animals, our hypothesis was that pretreatment with donepezil would attenuate the perceived value and other positive subjective effects of cocaine. Donepezil 141-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-12 20104942-3 2010 Memantine has a distinct mode of action compared with that of acetylcholinesterase (AChE) inhibitors, and in a well designed study, combination therapy with memantine plus donepezil improved outcomes more than donepezil plus placebo in all four domains (function, cognition, behaviour and global change). Memantine 157-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 20104942-3 2010 Memantine has a distinct mode of action compared with that of acetylcholinesterase (AChE) inhibitors, and in a well designed study, combination therapy with memantine plus donepezil improved outcomes more than donepezil plus placebo in all four domains (function, cognition, behaviour and global change). Memantine 157-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 19954865-0 2010 Synthesis and AChE inhibitory activity of new chiral tetrahydroacridine analogues from terpenic cyclanones. 1,2,3,4-Tetrahydroacridine 53-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 20005727-0 2010 Bisquaternary pyridinium oximes: Comparison of in vitro reactivation potency of compounds bearing aliphatic linkers and heteroaromatic linkers for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase. bisquaternary pyridinium oximes 0-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 201-221 20005727-2 2010 The purpose of the present study was to evaluate new oxime compounds to reactivate acetylcholinesterase (AChE) inhibited by the OP paraoxon. Oximes 53-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 20005727-2 2010 The purpose of the present study was to evaluate new oxime compounds to reactivate acetylcholinesterase (AChE) inhibited by the OP paraoxon. Oximes 53-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 20005727-7 2010 Interestingly, oximes with a heterocyclic linker inhibited AChE at higher concentration (10(-3)M), whereas their ability to reactivate was increased at lower concentrations (10(-4)M and 10(-5)M). Oximes 15-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 19838684-11 2010 Acetaminophen exposure significantly increased hepatic LPO levels and inhibited AChE activity in gill (10-day NOEC and LOEC of 23 and 403 microg/L, respectively), whereas propranolol (11 microg/L) enhanced gill GST. Acetaminophen 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 20147000-2 2010 Eight farmers had 30% to 50% baseline AChE activity, which suggests chronic organophosphate insecticide poisoning. Organophosphates 76-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 20422942-2 2010 BACKGROUND: Donepezil hydrochloride (CAS 120014-06-4) is a piperidine-based, reversible inhibitor of the enzyme acetylcholinesterase (AChE). Donepezil 12-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 20422942-2 2010 BACKGROUND: Donepezil hydrochloride (CAS 120014-06-4) is a piperidine-based, reversible inhibitor of the enzyme acetylcholinesterase (AChE). Donepezil 12-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 20422942-2 2010 BACKGROUND: Donepezil hydrochloride (CAS 120014-06-4) is a piperidine-based, reversible inhibitor of the enzyme acetylcholinesterase (AChE). piperidine 59-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 20422942-2 2010 BACKGROUND: Donepezil hydrochloride (CAS 120014-06-4) is a piperidine-based, reversible inhibitor of the enzyme acetylcholinesterase (AChE). piperidine 59-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 20422942-4 2010 This is accomplished by increasing the concentration of acetylcholine (ACh) through reversible inhibition of its hydrolysis by AChE. Acetylcholine 56-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 20422942-4 2010 This is accomplished by increasing the concentration of acetylcholine (ACh) through reversible inhibition of its hydrolysis by AChE. Acetylcholine 71-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 20712136-0 2010 Synthesis and antimicrobial, acetylcholinesterase and butyrylcholinesterase inhibitory activities of novel ester and hydrazide derivatives of 3(2H)-pyridazinone. 2-phenyl-3(2H)-pyridazinone 142-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 20712136-1 2010 In the current study, some novel ethyl 6- [(substituted-phenylpiperazine]-3(2H)-pyridazinone-2-yl propionate III and 6-[(substituted-phenylpiperazine]-3(2H)-pyridazinone-2-yl propionohydrazide IV derivatives were synthesized as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. ethyl 6- [(substituted-phenylpiperazine]-3(2h)-pyridazinone-2-yl propionate 33-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 228-248 20712136-1 2010 In the current study, some novel ethyl 6- [(substituted-phenylpiperazine]-3(2H)-pyridazinone-2-yl propionate III and 6-[(substituted-phenylpiperazine]-3(2H)-pyridazinone-2-yl propionohydrazide IV derivatives were synthesized as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. ethyl 6- [(substituted-phenylpiperazine]-3(2h)-pyridazinone-2-yl propionate 33-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 250-254 20712136-1 2010 In the current study, some novel ethyl 6- [(substituted-phenylpiperazine]-3(2H)-pyridazinone-2-yl propionate III and 6-[(substituted-phenylpiperazine]-3(2H)-pyridazinone-2-yl propionohydrazide IV derivatives were synthesized as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. 6-[(substituted-phenylpiperazine]-3(2h)-pyridazinone-2-yl propionohydrazide 117-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 228-248 20712136-1 2010 In the current study, some novel ethyl 6- [(substituted-phenylpiperazine]-3(2H)-pyridazinone-2-yl propionate III and 6-[(substituted-phenylpiperazine]-3(2H)-pyridazinone-2-yl propionohydrazide IV derivatives were synthesized as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. 6-[(substituted-phenylpiperazine]-3(2h)-pyridazinone-2-yl propionohydrazide 117-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 250-254 20410609-0 2010 Piperidine-4-methanthiol ester derivatives for a selective acetylcholinesterase assay. piperidine-4-methanthiol ester 0-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 20410609-5 2010 The hydrolysis rate of the novel compounds by human AChE was one order of magnitude lower than that of the traditional substrates, acetylthiocholine and acetyl-beta-methylthiocholine, whereas the hydrolysis rate using human butyrylcholinesterase was two orders of magnitude lower than that of the traditional substrates. Acetylthiocholine 131-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 20410609-5 2010 The hydrolysis rate of the novel compounds by human AChE was one order of magnitude lower than that of the traditional substrates, acetylthiocholine and acetyl-beta-methylthiocholine, whereas the hydrolysis rate using human butyrylcholinesterase was two orders of magnitude lower than that of the traditional substrates. acetyl-beta-(methylthio)choline 153-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 20522977-0 2010 Donepezil, a potent acetylcholinesterase inhibitor, induces caspase-dependent apoptosis in human promyelocytic leukemia HL-60 cells. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 20522977-1 2010 Although donepezil, a potent acetylcholinesterase (AChE) inhibitor, has been used to treat Alzheimer"s disease (AD) due to its neuroprotective effects, its mode of action to inhibit the growth of cancer cells is poorly understood. Donepezil 9-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 20522977-1 2010 Although donepezil, a potent acetylcholinesterase (AChE) inhibitor, has been used to treat Alzheimer"s disease (AD) due to its neuroprotective effects, its mode of action to inhibit the growth of cancer cells is poorly understood. Donepezil 9-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 19877295-3 2010 Enzymatic hydrolysis of acetylcholine in the synaptic cleft is fast and quickly metabolizes to choline and acetate by acetylcholinesterase. Acetylcholine 24-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 19877295-3 2010 Enzymatic hydrolysis of acetylcholine in the synaptic cleft is fast and quickly metabolizes to choline and acetate by acetylcholinesterase. Choline 30-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 19877295-3 2010 Enzymatic hydrolysis of acetylcholine in the synaptic cleft is fast and quickly metabolizes to choline and acetate by acetylcholinesterase. Acetates 107-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 20890554-2 2010 OBJECTIVE: The acetylcholinesterase activity was determined in study participants with a history of organophosphate and carbamate exposure and the most commonly used pesticides were identified in each study area. Organophosphates 100-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 20890554-2 2010 OBJECTIVE: The acetylcholinesterase activity was determined in study participants with a history of organophosphate and carbamate exposure and the most commonly used pesticides were identified in each study area. Carbamates 120-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 20028185-10 2010 The in silico pharmacophore model of oxime affinity for binding to GA-inhibited AChE was found to require a hydrogen bond acceptor, a hydrogen bond donor at the two terminal regions, and an aromatic ring in the central region of the oximes. Hydrogen 108-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 20028185-1 2010 Organophosphorus (OP) nerve agents that inhibit acetylcholinesterase (AChE; EC 3.1.1.7) function in the nervous system, causing acute intoxication. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 20028185-1 2010 Organophosphorus (OP) nerve agents that inhibit acetylcholinesterase (AChE; EC 3.1.1.7) function in the nervous system, causing acute intoxication. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 20028185-3 2010 Inhibited AChE can be reactivated by oximes, antidotes for OP exposure. Oximes 37-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-14 20028185-4 2010 However, OP intoxication caused by the nerve agent tabun (GA) is particularly resistant to oximes, which poorly reactivate GA-inhibited AChE. Oximes 91-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 20028185-5 2010 In an attempt to develop a rational strategy for the discovery and design of novel reactivators with lower toxicity and increased efficacy in reactivating GA-inhibited AChE, we developed the first in silico pharmacophore model for binding affinity of GA-inhibited AChE from a set of 11 oximes. Gallium 155-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-172 20028185-5 2010 In an attempt to develop a rational strategy for the discovery and design of novel reactivators with lower toxicity and increased efficacy in reactivating GA-inhibited AChE, we developed the first in silico pharmacophore model for binding affinity of GA-inhibited AChE from a set of 11 oximes. Gallium 155-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 264-268 20028185-5 2010 In an attempt to develop a rational strategy for the discovery and design of novel reactivators with lower toxicity and increased efficacy in reactivating GA-inhibited AChE, we developed the first in silico pharmacophore model for binding affinity of GA-inhibited AChE from a set of 11 oximes. Oximes 286-292 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-172 20028185-5 2010 In an attempt to develop a rational strategy for the discovery and design of novel reactivators with lower toxicity and increased efficacy in reactivating GA-inhibited AChE, we developed the first in silico pharmacophore model for binding affinity of GA-inhibited AChE from a set of 11 oximes. Oximes 286-292 acetylcholinesterase (Cartwright blood group) Homo sapiens 264-268 20028185-7 2010 Quantum chemical methods were sequentially used from semiempirical AM1 to hierarchical ab initio calculations to determine the stereoelectronic properties of nine oximes exhibiting affinity for binding to GA-inhibited AChE in vivo. Oximes 163-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 218-222 20028185-7 2010 Quantum chemical methods were sequentially used from semiempirical AM1 to hierarchical ab initio calculations to determine the stereoelectronic properties of nine oximes exhibiting affinity for binding to GA-inhibited AChE in vivo. Gallium 205-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 218-222 20028185-10 2010 The in silico pharmacophore model of oxime affinity for binding to GA-inhibited AChE was found to require a hydrogen bond acceptor, a hydrogen bond donor at the two terminal regions, and an aromatic ring in the central region of the oximes. Oximes 37-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 20028185-10 2010 The in silico pharmacophore model of oxime affinity for binding to GA-inhibited AChE was found to require a hydrogen bond acceptor, a hydrogen bond donor at the two terminal regions, and an aromatic ring in the central region of the oximes. Hydrogen 134-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 20028185-10 2010 The in silico pharmacophore model of oxime affinity for binding to GA-inhibited AChE was found to require a hydrogen bond acceptor, a hydrogen bond donor at the two terminal regions, and an aromatic ring in the central region of the oximes. Oximes 233-239 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 20028185-11 2010 The model was found to be well-correlated (R = 0.9) with experimental oxime affinity for binding to GA-inhibited AChE. Oximes 70-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 20028185-11 2010 The model was found to be well-correlated (R = 0.9) with experimental oxime affinity for binding to GA-inhibited AChE. Gallium 100-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 20028185-13 2010 These results provided the first predictive pharmacophore model of oxime affinity for binding toward GA-inhibited AChE. Oximes 67-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 20028185-13 2010 These results provided the first predictive pharmacophore model of oxime affinity for binding toward GA-inhibited AChE. Gallium 101-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 20214575-5 2010 Finally, in vitro testing of selected compounds led to the identification of forsythoside A and (+)-sesamolin as novel AChE inhibitors. forsythiaside 77-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 20214575-5 2010 Finally, in vitro testing of selected compounds led to the identification of forsythoside A and (+)-sesamolin as novel AChE inhibitors. sesamolin 96-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 20345341-9 2010 This review will focus on and summarize the last two years of research into the development of tacrine derivatives able to hit AD targets beyond simple AChE inhibition. Tacrine 95-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 20345342-10 2010 Among data found in the literature, many compounds have shown promising inhibition of AChE when compared to commercial standards (pyridostigmine, neostigmine). Pyridostigmine Bromide 130-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 20345342-10 2010 Among data found in the literature, many compounds have shown promising inhibition of AChE when compared to commercial standards (pyridostigmine, neostigmine). Neostigmine 146-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 20345348-4 2010 It also focuses on the organophosphorus nerve agents, their properties, effects and a large part describes various possibilities in treatments, mainly traditional oxime therapies based on reactivation of AChE. organophosphorus 23-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-208 20345348-4 2010 It also focuses on the organophosphorus nerve agents, their properties, effects and a large part describes various possibilities in treatments, mainly traditional oxime therapies based on reactivation of AChE. Oximes 163-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-208 20698824-5 2010 Some dual binding site AChE inhibitors take on added value a significant ability to additionally inhibit the enzymes butyrylcholinesterase and BACE-1, involved in the co-regulation of the hydrolysis of the neurotransmitter acetylcholine and in Abeta formation, respectively. Acetylcholine 223-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 19954865-0 2010 Synthesis and AChE inhibitory activity of new chiral tetrahydroacridine analogues from terpenic cyclanones. terpenic cyclanones 87-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 19954865-3 2010 The 9-aminotetrahydroacridine analogues were tested as acetylcholinesterase (AChE) inhibitors. 9-aminotetrahydroacridine 4-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 19954865-3 2010 The 9-aminotetrahydroacridine analogues were tested as acetylcholinesterase (AChE) inhibitors. 9-aminotetrahydroacridine 4-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 19680821-2 2010 Proline-rich membrane anchor (PRiMA)-linked tetrameric globular AChE (G4 AChE) is mainly found in the vertebrate brain; however, recent studies from our laboratory have suggested its existence at neuromuscular junctions (nmjs). Proline 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 19680821-2 2010 Proline-rich membrane anchor (PRiMA)-linked tetrameric globular AChE (G4 AChE) is mainly found in the vertebrate brain; however, recent studies from our laboratory have suggested its existence at neuromuscular junctions (nmjs). Proline 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 19757206-1 2010 Acetylcholinesterase (AChE) hydrolyzes its physiological substrate acetylcholine at one of the highest known catalytic rates. Acetylcholine 67-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 19757206-1 2010 Acetylcholinesterase (AChE) hydrolyzes its physiological substrate acetylcholine at one of the highest known catalytic rates. Acetylcholine 67-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 20402654-1 2010 A novel acetylcholinesterase (AChE) reactivator, a bispyridinium aldoxime named K048, was first synthesized in 2003. bispyridinium aldoxime 51-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-28 20402654-1 2010 A novel acetylcholinesterase (AChE) reactivator, a bispyridinium aldoxime named K048, was first synthesized in 2003. bispyridinium aldoxime 51-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 20402654-1 2010 A novel acetylcholinesterase (AChE) reactivator, a bispyridinium aldoxime named K048, was first synthesized in 2003. (-)-Carvone 80-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-28 20402654-1 2010 A novel acetylcholinesterase (AChE) reactivator, a bispyridinium aldoxime named K048, was first synthesized in 2003. (-)-Carvone 80-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 20402654-6 2010 Our results showed that oxime K048 reached promising reactivation activity in case of all tested AChE inhibitors, except cyclosarin, at oxime concentration 10(-3) M. At a concentration of 10(-5) M, which is more common for human use, only methylchlorpyrifos-inhibited AChE was reactivated. oxime k048 24-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 20402654-6 2010 Our results showed that oxime K048 reached promising reactivation activity in case of all tested AChE inhibitors, except cyclosarin, at oxime concentration 10(-3) M. At a concentration of 10(-5) M, which is more common for human use, only methylchlorpyrifos-inhibited AChE was reactivated. oxime k048 24-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 268-272 20402654-6 2010 Our results showed that oxime K048 reached promising reactivation activity in case of all tested AChE inhibitors, except cyclosarin, at oxime concentration 10(-3) M. At a concentration of 10(-5) M, which is more common for human use, only methylchlorpyrifos-inhibited AChE was reactivated. Oximes 24-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 20402654-6 2010 Our results showed that oxime K048 reached promising reactivation activity in case of all tested AChE inhibitors, except cyclosarin, at oxime concentration 10(-3) M. At a concentration of 10(-5) M, which is more common for human use, only methylchlorpyrifos-inhibited AChE was reactivated. Oximes 24-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 268-272 20173328-2 2010 Here, we report that modified composition, localization and properties of alternative splice variants encoding the acetylcholine-hydrolyzing enzyme acetylcholinesterase (AChE) may be variably involved in disease progression or in systemic efforts to attenuate its progression. Acetylcholine 115-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-168 20173328-2 2010 Here, we report that modified composition, localization and properties of alternative splice variants encoding the acetylcholine-hydrolyzing enzyme acetylcholinesterase (AChE) may be variably involved in disease progression or in systemic efforts to attenuate its progression. Acetylcholine 115-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 22294918-2 2010 Enzymatic amperometric procedures for measuring arsenic, based on the inhibitive action of this metal on acetylcholinesterase enzyme activity, have been developed. Arsenic 48-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 22294918-2 2010 Enzymatic amperometric procedures for measuring arsenic, based on the inhibitive action of this metal on acetylcholinesterase enzyme activity, have been developed. Metals 96-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 22294918-3 2010 Screen-printed carbon electrodes (SPCEs) were used with acetylcholinesterase covalently bonded directly to its surface. Carbon 15-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 22294918-4 2010 The amperometric response of acetylcholinesterase was affected by the presence of arsenic ions, which caused a decrease in the current intensity. Arsenic 82-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 21389938-2 2010 Given this conception, we conducted a controlled study of efficacy and safety of acetylcholinesterase inhibitor rivastigmine in patients developed a delirium in the acute phase of ischemic stroke. Rivastigmine 112-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 19924840-0 2009 Reaction pathway and free-energy barrier for reactivation of dimethylphosphoryl-inhibited human acetylcholinesterase. dimethylphosphoryl 61-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 19924840-1 2009 The dephosphorylation/reactivation mechanism and the corresponding free-energy profile of the dimethylphosphoryl-inhibited conjugate of human acetylcholinesterase (AChE) has been studied by performing first-principles quantum mechanical/molecular mechanical free-energy (QM/MM-FE) calculations. dimethylphosphoryl 94-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 19924840-1 2009 The dephosphorylation/reactivation mechanism and the corresponding free-energy profile of the dimethylphosphoryl-inhibited conjugate of human acetylcholinesterase (AChE) has been studied by performing first-principles quantum mechanical/molecular mechanical free-energy (QM/MM-FE) calculations. dimethylphosphoryl 94-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 20641589-15 2004 The esterase activity of BChE plays an important role in scavenging anti-AChE compounds such as cocaine, heroin, and organophosphate before they reach AChE at physiologically important sites. Cocaine 96-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 19642642-7 2009 Furthermore, the crystal structure of the ternary complex of the aged conjugate with 2-PAM revealed that the orientation of the oxime function does not permit nucleophilic attack on the phosphorus atom, thus providing a plausible explanation for its failure to reactivate the aged soman/AChE conjugate. Oximes 128-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 287-291 19663821-5 2009 Both HI-6 and irinotecan inhibited ChE/AChE activity but showed different levels of ChE inhibition in plasma and AChE inhibition in the liver and brain tissue. asoxime chloride 5-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 19663821-5 2009 Both HI-6 and irinotecan inhibited ChE/AChE activity but showed different levels of ChE inhibition in plasma and AChE inhibition in the liver and brain tissue. asoxime chloride 5-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 19663821-5 2009 Both HI-6 and irinotecan inhibited ChE/AChE activity but showed different levels of ChE inhibition in plasma and AChE inhibition in the liver and brain tissue. Irinotecan 14-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 19663821-5 2009 Both HI-6 and irinotecan inhibited ChE/AChE activity but showed different levels of ChE inhibition in plasma and AChE inhibition in the liver and brain tissue. Irinotecan 14-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 19843075-0 2009 Ligand-based 3D-QSAR studies of physostigmine analogues as acetylcholinesterase inhibitors. Physostigmine 32-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 19843075-1 2009 Natural alkaloid Physostigmine is one of the most potent pseudo-irreversible inhibitor of Acetylcholinesterase. Physostigmine 17-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 19843075-7 2009 Furthermore, the analysis of comparative molecular field analysis and comparative molecular similarity indices analysis contour maps within the active site of AChE were conducted in order to understand the interactions between the receptor and the Physostigmine derivatives. Physostigmine 248-261 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 19761810-1 2009 The nerve agent tabun inhibits the essential enzyme acetylcholinesterase (AChE) by a rapid phosphoramidation of the catalytic serine residue. Serine 126-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 19761810-1 2009 The nerve agent tabun inhibits the essential enzyme acetylcholinesterase (AChE) by a rapid phosphoramidation of the catalytic serine residue. Serine 126-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 19761810-2 2009 Oximes, such as K027 and HLo-7, can reactivate tabun-inhibited human AChE (tabun-hAChE) whereas the activity of their close structural analogue HI-6 is notably low. Oximes 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 19761810-2 2009 Oximes, such as K027 and HLo-7, can reactivate tabun-inhibited human AChE (tabun-hAChE) whereas the activity of their close structural analogue HI-6 is notably low. Oximes 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-86 19761810-3 2009 To investigate HI-6, K027 and HLo-7, residues lining the active-site gorge of hAChE were substituted and the effects on kinetic parameters for reactivation were determined. asoxime chloride 15-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-83 19856923-3 2009 At submicromolar concentration, they inhibit AChE and butyrylcholinesterase (BuChE) of human origin, displace the binding of propidium iodide from the PAS of AChE, and could thus inhibit Abeta aggregation promoted by AChE. Propidium 125-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 19856923-3 2009 At submicromolar concentration, they inhibit AChE and butyrylcholinesterase (BuChE) of human origin, displace the binding of propidium iodide from the PAS of AChE, and could thus inhibit Abeta aggregation promoted by AChE. Propidium 125-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 19699261-2 2009 We previously reported that BT-11, extracted from the roots of the plant, improved memory impairments in rats, enhanced memory in normal humans, and inhibited acetylcholinesterase activities in vitro. BT-11 28-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 19596285-3 2009 The in vitro results showed that quercetin and macluraxanthone displayed a concentration-dependant inhibition of AChE and BChE. Quercetin 33-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 19596285-3 2009 The in vitro results showed that quercetin and macluraxanthone displayed a concentration-dependant inhibition of AChE and BChE. Macluraxanthone 47-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 19596285-5 2009 The enzyme kinetic studies revealed that quercetin inhibited both the enzymes in competitive manner, whereas the mode of inhibition of macluraxanthone was non-competitive against AChE and competitive against BChE. Macluraxanthone 135-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 179-183 19596285-6 2009 The inhibitory profiles of the compounds have been compared with standard AChE inhibitor galanthamine. Galantamine 89-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 19651196-4 2009 AChE inhibition results in the accumulation of acetylcholine at cholinergic receptor sites, producing continuous stimulation of cholinergic fibers throughout the nervous systems. Acetylcholine 47-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 19752726-6 2009 Acetylcholinesterase inhibitor reversal can cause respiratory side effects, so the lowest efficacious dose should be used: as little as 0.015-0.025 mg kg(-1) of neostigmine is required at a train-of-four count of four with minimal fade. Neostigmine 161-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 20032868-0 2009 Novel bisquaternary oximes--reactivation of acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon. Oximes 20-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 20032868-0 2009 Novel bisquaternary oximes--reactivation of acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon. Paraoxon 104-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 20032868-4 2009 As it resulted, none of the prepared compounds surpassed obidoxime, which is considered to be the most potent compound if used for reactivation of AChE inhibited by paraoxon. Obidoxime Chloride 57-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 20032868-4 2009 As it resulted, none of the prepared compounds surpassed obidoxime, which is considered to be the most potent compound if used for reactivation of AChE inhibited by paraoxon. Paraoxon 165-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 19902122-4 2009 In HEK293T cells, RanBPM and AChE were heterogeneously expressed in the cisplatin-untreated cytoplasmic extracts and in the cisplatin-treated cytoplasmic or nuclear extracts. Cisplatin 72-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 19902122-4 2009 In HEK293T cells, RanBPM and AChE were heterogeneously expressed in the cisplatin-untreated cytoplasmic extracts and in the cisplatin-treated cytoplasmic or nuclear extracts. Cisplatin 124-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 19580698-5 2009 In the present study we investigated the impact of a 15-month treatment with the AChE inhibitor donepezil on blood levels of the HGFs stem cell factor (SCF), stromal cell-derived factor 1 (SDF-1), granulocyte colony- stimulating factor (G-CSF) and vascular endothelial growth factor (VEGF) in 19 patients with AD and 45 age-matched healthy controls. Donepezil 96-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 18716607-1 2009 The objective of this study was to evaluate the quantitative relation between measured red blood cell acetylcholinesterase (RBC AChE) and plasma butyrylcholinesterase (BuChE) activities with exposure to chlorpyrifos (CPF) as assessed by measurement of urinary 3,5,6-trichloro-2-pyridinol (TCPy) in a study group of workers occupationally exposed in the manufacture of CPF and a referent group of chemical manufacturing workers. Chlorpyrifos 203-215 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 18716607-1 2009 The objective of this study was to evaluate the quantitative relation between measured red blood cell acetylcholinesterase (RBC AChE) and plasma butyrylcholinesterase (BuChE) activities with exposure to chlorpyrifos (CPF) as assessed by measurement of urinary 3,5,6-trichloro-2-pyridinol (TCPy) in a study group of workers occupationally exposed in the manufacture of CPF and a referent group of chemical manufacturing workers. Chlorpyrifos 217-220 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 18716607-1 2009 The objective of this study was to evaluate the quantitative relation between measured red blood cell acetylcholinesterase (RBC AChE) and plasma butyrylcholinesterase (BuChE) activities with exposure to chlorpyrifos (CPF) as assessed by measurement of urinary 3,5,6-trichloro-2-pyridinol (TCPy) in a study group of workers occupationally exposed in the manufacture of CPF and a referent group of chemical manufacturing workers. 3,5,6-trichloro-2-pyridinol 260-287 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 18716607-1 2009 The objective of this study was to evaluate the quantitative relation between measured red blood cell acetylcholinesterase (RBC AChE) and plasma butyrylcholinesterase (BuChE) activities with exposure to chlorpyrifos (CPF) as assessed by measurement of urinary 3,5,6-trichloro-2-pyridinol (TCPy) in a study group of workers occupationally exposed in the manufacture of CPF and a referent group of chemical manufacturing workers. 3,5,6-trichloro-2-pyridinol 289-293 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 18716607-1 2009 The objective of this study was to evaluate the quantitative relation between measured red blood cell acetylcholinesterase (RBC AChE) and plasma butyrylcholinesterase (BuChE) activities with exposure to chlorpyrifos (CPF) as assessed by measurement of urinary 3,5,6-trichloro-2-pyridinol (TCPy) in a study group of workers occupationally exposed in the manufacture of CPF and a referent group of chemical manufacturing workers. Chlorpyrifos 368-371 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 19565307-2 2009 Inhibitors of acetylcholinesterase (AChE) are used in the treatment of myasthenia gravis, Alzheimer"s disease, and in the prophylaxis of poisoning with organophosphates. Organophosphates 152-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 19565307-2 2009 Inhibitors of acetylcholinesterase (AChE) are used in the treatment of myasthenia gravis, Alzheimer"s disease, and in the prophylaxis of poisoning with organophosphates. Organophosphates 152-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 19737786-2 2009 This chemical structure affects their responsiveness to oxime-induced acetylcholinesterase (AChE) reactivation after poisoning. Oximes 56-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 20641589-15 2004 The esterase activity of BChE plays an important role in scavenging anti-AChE compounds such as cocaine, heroin, and organophosphate before they reach AChE at physiologically important sites. Heroin 105-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 20641589-15 2004 The esterase activity of BChE plays an important role in scavenging anti-AChE compounds such as cocaine, heroin, and organophosphate before they reach AChE at physiologically important sites. Organophosphates 117-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 20641589-27 2004 N-methylpiperidinyl esters are a group of synthetic AChE substrates; of them, 1-(11)C-methyl-4-piperidinyl acetate ((11)C-MP4A) and 1-(11)C-methyl-4-piperidinyl propionate ((11)C-MP4P) have already been used in the clinic as PET tracers for in vivo assessment of AChE activity associated with AD. n-methylpiperidinyl esters 0-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 20641589-27 2004 N-methylpiperidinyl esters are a group of synthetic AChE substrates; of them, 1-(11)C-methyl-4-piperidinyl acetate ((11)C-MP4A) and 1-(11)C-methyl-4-piperidinyl propionate ((11)C-MP4P) have already been used in the clinic as PET tracers for in vivo assessment of AChE activity associated with AD. n-methylpiperidinyl esters 0-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 263-267 20641589-27 2004 N-methylpiperidinyl esters are a group of synthetic AChE substrates; of them, 1-(11)C-methyl-4-piperidinyl acetate ((11)C-MP4A) and 1-(11)C-methyl-4-piperidinyl propionate ((11)C-MP4P) have already been used in the clinic as PET tracers for in vivo assessment of AChE activity associated with AD. 1-(11)c-methyl-4-piperidinyl acetate 78-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 20641589-27 2004 N-methylpiperidinyl esters are a group of synthetic AChE substrates; of them, 1-(11)C-methyl-4-piperidinyl acetate ((11)C-MP4A) and 1-(11)C-methyl-4-piperidinyl propionate ((11)C-MP4P) have already been used in the clinic as PET tracers for in vivo assessment of AChE activity associated with AD. 1-(11)c-methyl-4-piperidinyl acetate 78-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 263-267 20641589-27 2004 N-methylpiperidinyl esters are a group of synthetic AChE substrates; of them, 1-(11)C-methyl-4-piperidinyl acetate ((11)C-MP4A) and 1-(11)C-methyl-4-piperidinyl propionate ((11)C-MP4P) have already been used in the clinic as PET tracers for in vivo assessment of AChE activity associated with AD. c-methyl-4-piperidinyl propionate 138-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 20641589-27 2004 N-methylpiperidinyl esters are a group of synthetic AChE substrates; of them, 1-(11)C-methyl-4-piperidinyl acetate ((11)C-MP4A) and 1-(11)C-methyl-4-piperidinyl propionate ((11)C-MP4P) have already been used in the clinic as PET tracers for in vivo assessment of AChE activity associated with AD. c-methyl-4-piperidinyl propionate 138-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 263-267 20641640-15 2004 The esterase activity of BChE plays an important role in scavenging anti-AChE compounds such as cocaine, heroin, and organophosphate before they reach AChE at physiologically important sites. Cocaine 96-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 20641640-15 2004 The esterase activity of BChE plays an important role in scavenging anti-AChE compounds such as cocaine, heroin, and organophosphate before they reach AChE at physiologically important sites. Heroin 105-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 20641640-15 2004 The esterase activity of BChE plays an important role in scavenging anti-AChE compounds such as cocaine, heroin, and organophosphate before they reach AChE at physiologically important sites. Organophosphates 117-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 19726199-0 2009 Rational design and synthesis of highly potent anti-acetylcholinesterase activity huperzine A derivatives. huperzine A 82-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 19726199-1 2009 By targeting multi-active sites of acetylcholinesterase (AChE), a series of huperzine A (Hup A) derivatives with various aromatic ring groups were designed and synthesized by Schiff reaction. huperzine A 76-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 19726199-1 2009 By targeting multi-active sites of acetylcholinesterase (AChE), a series of huperzine A (Hup A) derivatives with various aromatic ring groups were designed and synthesized by Schiff reaction. huperzine A 76-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 19726199-1 2009 By targeting multi-active sites of acetylcholinesterase (AChE), a series of huperzine A (Hup A) derivatives with various aromatic ring groups were designed and synthesized by Schiff reaction. schiff 175-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 19726199-1 2009 By targeting multi-active sites of acetylcholinesterase (AChE), a series of huperzine A (Hup A) derivatives with various aromatic ring groups were designed and synthesized by Schiff reaction. schiff 175-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 19726199-5 2009 In the docking model, we confirmed that aromatic ring of Hup A derivatives played the pi-pi stacking against aminophenol residues of AChE, and the structure-activity relationship (SAR) was discussed. Aminophenols 109-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 19715346-5 2009 Inhibition kinetic studies of the thiomethyl- and thiocholine-substituted series of nerve agent model compounds revealed that the S(p) enantiomers of both series of compounds showed greater inhibition potency toward AChE and BChE. thiomethyl 34-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 216-220 19715346-5 2009 Inhibition kinetic studies of the thiomethyl- and thiocholine-substituted series of nerve agent model compounds revealed that the S(p) enantiomers of both series of compounds showed greater inhibition potency toward AChE and BChE. Thiocholine 50-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 216-220 19678754-2 2009 Symptomatic effects are mediated by the inhibition of acetyl- and/or butyryl-cholinesterase (AChE and/or BuChE) - the enzymes that degrade acetylcholine (ACh) in the synapse. Acetylcholine 139-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 19739697-3 2009 Memantine has a distinct mode of action compared with that of acetylcholinesterase (AChE) inhibitors, and in a well designed study, combination therapy with memantine plus donepezil improved outcomes more than donepezil plus placebo in all four domains (function, cognition, behaviour and global change). Memantine 157-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 19739697-3 2009 Memantine has a distinct mode of action compared with that of acetylcholinesterase (AChE) inhibitors, and in a well designed study, combination therapy with memantine plus donepezil improved outcomes more than donepezil plus placebo in all four domains (function, cognition, behaviour and global change). Memantine 157-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 19757435-1 2009 The hydrolysis of acetylcholine and acetylthiocholine as catalyzed by the enzyme acetylcholinesterase was monitored by CE with contactless conductivity detection by determining the acetate produced in the reaction. Acetylcholine 18-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 19757435-1 2009 The hydrolysis of acetylcholine and acetylthiocholine as catalyzed by the enzyme acetylcholinesterase was monitored by CE with contactless conductivity detection by determining the acetate produced in the reaction. Acetylthiocholine 36-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 19757435-1 2009 The hydrolysis of acetylcholine and acetylthiocholine as catalyzed by the enzyme acetylcholinesterase was monitored by CE with contactless conductivity detection by determining the acetate produced in the reaction. Acetates 181-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 19555175-1 2009 Molecular Dynamics (MD) simulations were carried out for human acetylcholinesterase (hAChE) and its complex with Axillaridine-A, in order to dynamically explore the active site of the protein and the behaviour of the ligand at the peripheral binding site. axillaridine-A 113-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-90 19555175-3 2009 The complexation of AChE with Axillaridine-A, results in the reduction of gorge size due to interaction between the ligand and the active site residues. axillaridine-A 30-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 19555175-9 2009 The MD results clearly provide an explanation for the binding pattern of bulky steroidal alkaloids at the active site of AChE. Alkaloids 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 19497294-4 2009 However, a fluorescently tagged potent inhibitor of AChE, TZ2PIQ-A6 with a K(d) of 33 fM, did not distinguish between the active and OP-inhibited RBC-AChE, nor did three different biotinylated OP compounds. tz2piq-a6 58-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 19692250-0 2009 Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors. Flavonoids 36-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 19692250-1 2009 A new series of flavonoid derivatives have been designed, synthesized and evaluated as potent AChE inhibitors. Flavonoids 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 19692250-3 2009 The most potent inhibitor isoflavone derivative 10d inhibit AChE with a IC(50) of 4 nM and showed high BChE/AChE inhibition ratio (4575-fold), superior to donepezil (IC(50)=12 nM, 389-fold). Isoflavones 26-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 19692250-3 2009 The most potent inhibitor isoflavone derivative 10d inhibit AChE with a IC(50) of 4 nM and showed high BChE/AChE inhibition ratio (4575-fold), superior to donepezil (IC(50)=12 nM, 389-fold). Isoflavones 26-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 19465093-1 2009 Oximes, including 2-pyridinealdoxime methiodide (2-PAM), are reactivators of acetylcholinesterase (AChE) inhibited by organophosphate poisoning. Oximes 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 19465093-1 2009 Oximes, including 2-pyridinealdoxime methiodide (2-PAM), are reactivators of acetylcholinesterase (AChE) inhibited by organophosphate poisoning. Oximes 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 19465093-1 2009 Oximes, including 2-pyridinealdoxime methiodide (2-PAM), are reactivators of acetylcholinesterase (AChE) inhibited by organophosphate poisoning. pralidoxime iodide 18-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 19465093-1 2009 Oximes, including 2-pyridinealdoxime methiodide (2-PAM), are reactivators of acetylcholinesterase (AChE) inhibited by organophosphate poisoning. pralidoxime iodide 18-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 19465093-1 2009 Oximes, including 2-pyridinealdoxime methiodide (2-PAM), are reactivators of acetylcholinesterase (AChE) inhibited by organophosphate poisoning. Organophosphates 118-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 19465093-1 2009 Oximes, including 2-pyridinealdoxime methiodide (2-PAM), are reactivators of acetylcholinesterase (AChE) inhibited by organophosphate poisoning. Organophosphates 118-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 19708709-1 2009 By making use of the aggregation-induced emission feature of compound 1 and the cascade reactions among acetylthiocholine iodide (ATC), AChE, and compound 2, a new fluorescence "turn-on" method is developed for AChE assay and inhibitor-screening. acetylthiocholine iodide 104-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-215 19708709-1 2009 By making use of the aggregation-induced emission feature of compound 1 and the cascade reactions among acetylthiocholine iodide (ATC), AChE, and compound 2, a new fluorescence "turn-on" method is developed for AChE assay and inhibitor-screening. acetylthiocholine iodide 130-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 19708709-1 2009 By making use of the aggregation-induced emission feature of compound 1 and the cascade reactions among acetylthiocholine iodide (ATC), AChE, and compound 2, a new fluorescence "turn-on" method is developed for AChE assay and inhibitor-screening. acetylthiocholine iodide 130-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-215 19540550-4 2009 A modified Ellman assay was used to measure AChE activity because nanoparticles could adsorb the yellowish product, 5"-mercapto-2"-nitrobenzoic acid (5-MNBA) during the color development. thionitrobenzoic acid 116-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 19651196-9 2009 Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the recommended pyridinium oximes (pralidoxime, trimedoxime, obidoxime and HI-6) and diazepam are used for the treatment of OP poisoning in humans. pyridinium oximes 116-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 19651196-9 2009 Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the recommended pyridinium oximes (pralidoxime, trimedoxime, obidoxime and HI-6) and diazepam are used for the treatment of OP poisoning in humans. pralidoxime 135-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 19651196-9 2009 Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the recommended pyridinium oximes (pralidoxime, trimedoxime, obidoxime and HI-6) and diazepam are used for the treatment of OP poisoning in humans. Obidoxime Chloride 161-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 19651196-9 2009 Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the recommended pyridinium oximes (pralidoxime, trimedoxime, obidoxime and HI-6) and diazepam are used for the treatment of OP poisoning in humans. asoxime chloride 175-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 19651196-9 2009 Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the recommended pyridinium oximes (pralidoxime, trimedoxime, obidoxime and HI-6) and diazepam are used for the treatment of OP poisoning in humans. Diazepam 185-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 19640713-0 2009 New series of monoquaternary pyridinium oximes: Synthesis and reactivation potency for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase. monoquaternary pyridinium oximes 14-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 19640713-0 2009 New series of monoquaternary pyridinium oximes: Synthesis and reactivation potency for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase. Paraoxon 87-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 19640713-1 2009 The preparation of a series of monoquaternary pyridinium oximes bearing either a heterocyclic side chain or a functionalized aliphatic side chain and the corresponding in vitro evaluation for reactivation of paraoxon-inhibited electric eel acetylcholinesterase (EeAChE) and recombinant human acetylcholinesterase (rHuAChE) are reported. monoquaternary pyridinium oximes 31-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 240-260 19640713-1 2009 The preparation of a series of monoquaternary pyridinium oximes bearing either a heterocyclic side chain or a functionalized aliphatic side chain and the corresponding in vitro evaluation for reactivation of paraoxon-inhibited electric eel acetylcholinesterase (EeAChE) and recombinant human acetylcholinesterase (rHuAChE) are reported. monoquaternary pyridinium oximes 31-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 292-312 19643609-2 2009 All the newly synthesized compounds were showing moderate to high AChE inhibitory activities, with compound 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenyl-3,4,5-trimethoxyphenylmethanone (5f) produced significant activities with 2.7+/-0.01 micromol/L. 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenyl-3,4,5-trimethoxyphenylmethanone 108-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 19433070-2 2009 Chlorpyrifos oxon (CPO) is the active metabolite of CPF that inhibits acetylcholinesterase. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 0-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 19433070-2 2009 Chlorpyrifos oxon (CPO) is the active metabolite of CPF that inhibits acetylcholinesterase. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 19-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 19433070-10 2009 CPO was present in sufficient quantities to explain any observed acetylcholinesterase inhibitory activity. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 19433070-11 2009 The effectiveness of pralidoxime in reactivating the inhibited acetylcholinesterase is strongly dependent on the CPO concentration. pralidoxime 21-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 19433070-11 2009 The effectiveness of pralidoxime in reactivating the inhibited acetylcholinesterase is strongly dependent on the CPO concentration. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 113-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 19540550-6 2009 Carbon nanotubes had high affinity for AChE adsorption, the highest being SWCNT (94%). Carbon 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 19540550-9 2009 However, Cu(2+) release in Cu and Cu-C nanoparticle suspensions caused 40% and 45% of AChE activity reduction, respectively. cupric ion 9-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 19540550-9 2009 However, Cu(2+) release in Cu and Cu-C nanoparticle suspensions caused 40% and 45% of AChE activity reduction, respectively. Copper 9-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 19540550-9 2009 However, Cu(2+) release in Cu and Cu-C nanoparticle suspensions caused 40% and 45% of AChE activity reduction, respectively. cu-c 34-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 19540550-10 2009 AChE inhibition by bulk Cu and activated carbon particles was also measured for comparison, showing that the inhibition by bulk particles was lower than their counterpart nanoparticles. Copper 24-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 19540550-10 2009 AChE inhibition by bulk Cu and activated carbon particles was also measured for comparison, showing that the inhibition by bulk particles was lower than their counterpart nanoparticles. Carbon 41-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 19540550-11 2009 For bulk Cu particles, AChE inhibition was primarily caused by dissolved ions, but mainly by adsorption for activated carbon. Copper 9-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 19540550-11 2009 For bulk Cu particles, AChE inhibition was primarily caused by dissolved ions, but mainly by adsorption for activated carbon. Carbon 118-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 19540550-12 2009 AChE inhibition by Cu, Cu-C, MWCNT and SWCNT had dose-response relationships, and their median inhibitory concentrations (IC(50)) were 4, 17, 156 and 96mgL(-1), respectively, showing that these nanoparticles may have neurotoxicity and AChE may have potential to be used as a biomarker for nanoparticles. Copper 19-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 19540550-12 2009 AChE inhibition by Cu, Cu-C, MWCNT and SWCNT had dose-response relationships, and their median inhibitory concentrations (IC(50)) were 4, 17, 156 and 96mgL(-1), respectively, showing that these nanoparticles may have neurotoxicity and AChE may have potential to be used as a biomarker for nanoparticles. Copper 19-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 235-239 19540550-12 2009 AChE inhibition by Cu, Cu-C, MWCNT and SWCNT had dose-response relationships, and their median inhibitory concentrations (IC(50)) were 4, 17, 156 and 96mgL(-1), respectively, showing that these nanoparticles may have neurotoxicity and AChE may have potential to be used as a biomarker for nanoparticles. cu-c 23-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 19540550-12 2009 AChE inhibition by Cu, Cu-C, MWCNT and SWCNT had dose-response relationships, and their median inhibitory concentrations (IC(50)) were 4, 17, 156 and 96mgL(-1), respectively, showing that these nanoparticles may have neurotoxicity and AChE may have potential to be used as a biomarker for nanoparticles. Carbon 39-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 19540550-12 2009 AChE inhibition by Cu, Cu-C, MWCNT and SWCNT had dose-response relationships, and their median inhibitory concentrations (IC(50)) were 4, 17, 156 and 96mgL(-1), respectively, showing that these nanoparticles may have neurotoxicity and AChE may have potential to be used as a biomarker for nanoparticles. Carbon 39-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 235-239 19778190-7 2009 CONCLUSIONS: Intense monitoring of organophosphate-poisoned patients allowed assessment of why a given obidoxime concentration was, or was not, able to counteract the re-inhibition of the RBC-AChE. Obidoxime Chloride 103-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 19778190-8 2009 RBC-AChE activity mirrors the function of n-receptor- and m-receptor-mediated cholinergic signaling as measured by neuromuscular transmission and atropine requirements. Atropine 146-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 19778163-5 2009 We measured the AChE activity in blood and related it to clinical features of organophosphate poisoning. Organophosphates 78-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 19778163-6 2009 RESULTS: Patients poisoned with parathion responded promptly to obidoxime (250 mg bolus followed by continuous infusion at 750 mg/day up to 1 week) with improvement of neuromuscular transmission and increased AChE activity. Parathion 32-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-213 19573265-1 2009 The acetylcholinesterase (AChE) inhibitor donepezil is also a sigma1 receptor agonist. Donepezil 42-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 19778163-6 2009 RESULTS: Patients poisoned with parathion responded promptly to obidoxime (250 mg bolus followed by continuous infusion at 750 mg/day up to 1 week) with improvement of neuromuscular transmission and increased AChE activity. Obidoxime Chloride 64-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-213 19778163-9 2009 CONCLUSIONS: Obidoxime appeared safe and reactivated AChE in parathion poisoning. Obidoxime Chloride 13-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 19764241-0 2009 Selective detection of hypertoxic organophosphates pesticides via PDMS composite based acetylcholinesterase-inhibition biosensor. Organophosphates 34-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 19764241-1 2009 We report on a pair of highly sensitive amperometric biosensors for organophosphate pesticides (OPs) based on assembling acetylcholinesterase (AChE) on poly(dimethylsiloxane) (PDMS)-poly(diallydimethylemmonium) (PDDA)/gold nanoparticles (AuNPs) composite film. Organophosphates 68-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 19764241-1 2009 We report on a pair of highly sensitive amperometric biosensors for organophosphate pesticides (OPs) based on assembling acetylcholinesterase (AChE) on poly(dimethylsiloxane) (PDMS)-poly(diallydimethylemmonium) (PDDA)/gold nanoparticles (AuNPs) composite film. Organophosphates 68-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 19764241-1 2009 We report on a pair of highly sensitive amperometric biosensors for organophosphate pesticides (OPs) based on assembling acetylcholinesterase (AChE) on poly(dimethylsiloxane) (PDMS)-poly(diallydimethylemmonium) (PDDA)/gold nanoparticles (AuNPs) composite film. OPS 96-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 19764241-1 2009 We report on a pair of highly sensitive amperometric biosensors for organophosphate pesticides (OPs) based on assembling acetylcholinesterase (AChE) on poly(dimethylsiloxane) (PDMS)-poly(diallydimethylemmonium) (PDDA)/gold nanoparticles (AuNPs) composite film. OPS 96-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 19764241-1 2009 We report on a pair of highly sensitive amperometric biosensors for organophosphate pesticides (OPs) based on assembling acetylcholinesterase (AChE) on poly(dimethylsiloxane) (PDMS)-poly(diallydimethylemmonium) (PDDA)/gold nanoparticles (AuNPs) composite film. baysilon 152-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 19764241-1 2009 We report on a pair of highly sensitive amperometric biosensors for organophosphate pesticides (OPs) based on assembling acetylcholinesterase (AChE) on poly(dimethylsiloxane) (PDMS)-poly(diallydimethylemmonium) (PDDA)/gold nanoparticles (AuNPs) composite film. baysilon 152-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 19764241-1 2009 We report on a pair of highly sensitive amperometric biosensors for organophosphate pesticides (OPs) based on assembling acetylcholinesterase (AChE) on poly(dimethylsiloxane) (PDMS)-poly(diallydimethylemmonium) (PDDA)/gold nanoparticles (AuNPs) composite film. poly( 152-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 19764241-1 2009 We report on a pair of highly sensitive amperometric biosensors for organophosphate pesticides (OPs) based on assembling acetylcholinesterase (AChE) on poly(dimethylsiloxane) (PDMS)-poly(diallydimethylemmonium) (PDDA)/gold nanoparticles (AuNPs) composite film. poly( 152-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 19764241-2 2009 Two AChE immobilization strategies are proposed based on the composite film with hydrophobic and hydrophilic surface tailored by oxygen plasma. Oxygen 129-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 19764241-4 2009 The hydrophobic surface based PDMS-PDDAN AuNPs/choline oxidase (ChO)/AChE biosensor (biosensor-1) shows excellent stability and unique selectivity to hypertoxic organophosphate. Organophosphates 161-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 19573265-1 2009 The acetylcholinesterase (AChE) inhibitor donepezil is also a sigma1 receptor agonist. Donepezil 42-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 19827033-1 2009 We have reported that benzene-1,2-, 1,3-, and 1,4-di-N-substituted carbamates (1-15) are characterized as the conformationally constrained inhibitors of acetylcholinesterase and mimic gauche, eclipsed, and anti-conformations of acetylcholine, respectively (J Biochem Mol Toxicol 2007;21:348-353). benzene-1,2-, 1,3-, and 1,4-di-n-substituted carbamates 22-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-173 19827033-3 2009 Carbamates 1-15 are also characterized as the pseudosubstrate inhibitors of butyrylcholinesterase as in the acetylcholinesterase catalysis. carbamates 1-15 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 19928287-5 2009 Inhibition of AChE by paraoxon is determined by the decrease in catalytic activity of AChE. Paraoxon 22-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 19928287-5 2009 Inhibition of AChE by paraoxon is determined by the decrease in catalytic activity of AChE. Paraoxon 22-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 19703368-9 2009 The maximum red blood cell AChE activity decrease (E(max)) and plasma pyridostigmine concentration producing 50% of this reduction (EC50) were estimated to be 9.32 AChE units per gram haemoglobin and 51.9 ng/ml, respectively. Pyridostigmine Bromide 70-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 19703368-12 2009 CONCLUSIONS: The pharmacokinetics and the effects of pyridostigmine on red blood cell AChE activity were described using a mixed effects model. Pyridostigmine Bromide 53-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 19603258-1 2009 PURPOSE: Acetylcholinesterase (AChE) is both a therapeutic target for Alzheimer"s disease and a target for organophosphorus, carbamates and chemical warfare agents. organophosphorus 107-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 19603258-1 2009 PURPOSE: Acetylcholinesterase (AChE) is both a therapeutic target for Alzheimer"s disease and a target for organophosphorus, carbamates and chemical warfare agents. organophosphorus 107-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 19603258-1 2009 PURPOSE: Acetylcholinesterase (AChE) is both a therapeutic target for Alzheimer"s disease and a target for organophosphorus, carbamates and chemical warfare agents. Carbamates 125-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 19603258-1 2009 PURPOSE: Acetylcholinesterase (AChE) is both a therapeutic target for Alzheimer"s disease and a target for organophosphorus, carbamates and chemical warfare agents. Carbamates 125-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 19603258-3 2009 MATERIALS AND METHODS: Support vector machine classification and regression models with molecular descriptors derived from Shape Signatures and the Molecular Operating Environment (MOE) application software were built and tested using a set of piperidine AChE inhibitors (N = 110). piperidine 244-254 acetylcholinesterase (Cartwright blood group) Homo sapiens 255-259 20046396-3 2009 Therefore, we investigated the alterations in stress hormones such as cortisol and dehydroepiandrosterone sulfate (DHEAS) in CFS patients before and after 4-week administration of galantamine hydrobromide, a selective acetylcholinesterase inhibitor, and aimed to investigate whether there are any relationships between the probable hormonal changes and cholinergic treatment. Galantamine 180-204 acetylcholinesterase (Cartwright blood group) Homo sapiens 218-238 19714254-2 2009 We previously reported the finding of a free cysteine (Cys) residue at the entrance of the active site of acetylcholinesterase (AChE) in some insects but not in mammals, birds, and fish. Cysteine 45-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 19714254-2 2009 We previously reported the finding of a free cysteine (Cys) residue at the entrance of the active site of acetylcholinesterase (AChE) in some insects but not in mammals, birds, and fish. Cysteine 55-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 19714254-3 2009 These insects have two AChE genes (AP and AO), and only AP-AChE carries the Cys residue. Cysteine 76-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 19714254-5 2009 Recently we reported a Cys-targeting small molecule that irreversibly inhibited all AChE activity extracted from aphids while an identical exposure caused no effect on the human AChE. Cysteine 23-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 19714254-6 2009 Full inhibition of AChE in aphids indicates that AP-AChE contributes most of the enzymatic activity and suggests that the Cys residue might serve as a target for developing better aphicides. Cysteine 122-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 19714254-6 2009 Full inhibition of AChE in aphids indicates that AP-AChE contributes most of the enzymatic activity and suggests that the Cys residue might serve as a target for developing better aphicides. Cysteine 122-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 19714254-8 2009 Herein, we report that, under conditions that spare the human AChE, a methanethiosulfonate-containing molecule at 6 microM irreversibly inhibited 95% of the AChE activity extracted from An. methanethiosulfonate 70-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 19714254-8 2009 Herein, we report that, under conditions that spare the human AChE, a methanethiosulfonate-containing molecule at 6 microM irreversibly inhibited 95% of the AChE activity extracted from An. methanethiosulfonate 70-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 19714254-11 2009 This type of inhibition is fast ( approximately 30 min) and due to conjugation of the inhibitor to the active-site Cys of mosquito AP-AChE, according to our observed reactivation of the methanethiosulfonate-inhibited AChE by 2-mercaptoethanol. Cysteine 115-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 19714254-11 2009 This type of inhibition is fast ( approximately 30 min) and due to conjugation of the inhibitor to the active-site Cys of mosquito AP-AChE, according to our observed reactivation of the methanethiosulfonate-inhibited AChE by 2-mercaptoethanol. Cysteine 115-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 217-221 19714254-11 2009 This type of inhibition is fast ( approximately 30 min) and due to conjugation of the inhibitor to the active-site Cys of mosquito AP-AChE, according to our observed reactivation of the methanethiosulfonate-inhibited AChE by 2-mercaptoethanol. methanethiosulfonate 186-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 19714254-11 2009 This type of inhibition is fast ( approximately 30 min) and due to conjugation of the inhibitor to the active-site Cys of mosquito AP-AChE, according to our observed reactivation of the methanethiosulfonate-inhibited AChE by 2-mercaptoethanol. methanethiosulfonate 186-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 217-221 19714254-11 2009 This type of inhibition is fast ( approximately 30 min) and due to conjugation of the inhibitor to the active-site Cys of mosquito AP-AChE, according to our observed reactivation of the methanethiosulfonate-inhibited AChE by 2-mercaptoethanol. Mercaptoethanol 225-242 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 19714254-11 2009 This type of inhibition is fast ( approximately 30 min) and due to conjugation of the inhibitor to the active-site Cys of mosquito AP-AChE, according to our observed reactivation of the methanethiosulfonate-inhibited AChE by 2-mercaptoethanol. Mercaptoethanol 225-242 acetylcholinesterase (Cartwright blood group) Homo sapiens 217-221 19539805-1 2009 Substances K-48 and HI-6, oxime-type acetylcholinesterase (AChE) reactivators, were tested for their potential to inhibit the activities of human liver microsomal cytochromes P450 (CYP). Histidine 20-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 19576448-0 2009 Magnesium effect on the acetylcholinesterase inhibition mechanism: a molecular chromatographic approach. Magnesium 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 19576448-1 2009 The acetylcholinesterase enzyme (AChE) was immobilized on a chromatographic support to study the effect of magnesium on the binding mechanism of five AChE inhibitors (donepezil, tacrine, galanthamine, physostigmine and huperzine). Magnesium 107-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 19651048-3 2009 A classic example of a diffusion-controlled biological reaction catalyzed by an oligomeric enzyme is the hydrolysis of synaptic acetylcholine (ACh) by tetrameric acetylcholinesterase (AChEt). Acetylcholine 128-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-182 19651048-3 2009 A classic example of a diffusion-controlled biological reaction catalyzed by an oligomeric enzyme is the hydrolysis of synaptic acetylcholine (ACh) by tetrameric acetylcholinesterase (AChEt). Acetylcholine 128-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-189 19651048-3 2009 A classic example of a diffusion-controlled biological reaction catalyzed by an oligomeric enzyme is the hydrolysis of synaptic acetylcholine (ACh) by tetrameric acetylcholinesterase (AChEt). Acetylcholine 143-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-182 19651048-3 2009 A classic example of a diffusion-controlled biological reaction catalyzed by an oligomeric enzyme is the hydrolysis of synaptic acetylcholine (ACh) by tetrameric acetylcholinesterase (AChEt). Acetylcholine 143-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-189 19505825-3 2009 The RR stereoisomer 2 resulted more effective than 1 in reverting two important effects mediated by acetylcholinesterase (AChE), that is, acetylcholine hydrolysis and AChE-induced amyloid-beta aggregation. Acetylcholine 100-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 19308922-6 2009 At sub-micromolar concentrations they efficiently displace the binding of propidium iodide from the PAS and could thus inhibit A beta peptide aggregation promoted by AChE. Propidium 74-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 19827033-0 2009 Comparison of active sites of butyrylcholinesterase and acetylcholinesterase based on inhibition by geometric isomers of benzene-di-N-substituted carbamates. benzene-di-n-substituted carbamates 121-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 19569635-1 2009 Dysfunction of acetylcholinesterase (AChE) due to inhibition by organophosphorus (OP) compounds is a major threat since AChE is a key enzyme in neurotransmission. organophosphorus 64-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 19569635-1 2009 Dysfunction of acetylcholinesterase (AChE) due to inhibition by organophosphorus (OP) compounds is a major threat since AChE is a key enzyme in neurotransmission. organophosphorus 64-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 19569635-1 2009 Dysfunction of acetylcholinesterase (AChE) due to inhibition by organophosphorus (OP) compounds is a major threat since AChE is a key enzyme in neurotransmission. organophosphorus 64-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 19520578-3 2009 The nucleosides as well as their sugar precursors were screened for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition. Nucleosides 4-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 19520578-3 2009 The nucleosides as well as their sugar precursors were screened for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition. Nucleosides 4-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 19492815-6 2009 AChE inhibitors, including paraoxon and aflatoxin B1, were detected successfully using this sensor by measuring the residual activity of AChE on paper, using Ellman"s colorimetric assay, with capture of the 5-thio-2-nitrobenzoate (TNB(-)) product on the PVAm layer. Trinitrobenzenesulfonic Acid 231-234 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 19492815-6 2009 AChE inhibitors, including paraoxon and aflatoxin B1, were detected successfully using this sensor by measuring the residual activity of AChE on paper, using Ellman"s colorimetric assay, with capture of the 5-thio-2-nitrobenzoate (TNB(-)) product on the PVAm layer. Trinitrobenzenesulfonic Acid 231-234 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 19492815-6 2009 AChE inhibitors, including paraoxon and aflatoxin B1, were detected successfully using this sensor by measuring the residual activity of AChE on paper, using Ellman"s colorimetric assay, with capture of the 5-thio-2-nitrobenzoate (TNB(-)) product on the PVAm layer. polyvinylamine 254-258 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 19492815-6 2009 AChE inhibitors, including paraoxon and aflatoxin B1, were detected successfully using this sensor by measuring the residual activity of AChE on paper, using Ellman"s colorimetric assay, with capture of the 5-thio-2-nitrobenzoate (TNB(-)) product on the PVAm layer. polyvinylamine 254-258 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 19468687-0 2009 Calcium signaling-induced Smad3 nuclear accumulation induces acetylcholinesterase transcription in apoptotic HeLa cells. Calcium 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 19468687-2 2009 We previously showed that cellular calcium mobilization upregulated AChE expression by modulating promoter activity and mRNA stability. Calcium 35-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 19468687-3 2009 In this study, we have identified a potential Smad3/4 binding element, TGCCAGACA, located within the -601 to -571 bp fragment of the AChE promoter, as an important calcium response motif. Calcium 164-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 19468687-7 2009 Calcium-induced AChE transcriptional activation was significantly blocked when the nuclear localization signal of Smad3 was destroyed. Calcium 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 19468687-8 2009 Taken together, our data suggest Smad3 can regulate AChE transcriptional activation following calcium-induced nuclear accumulation. Calcium 94-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 19586353-0 2009 In vitro oxime-assisted reactivation of paraoxon-inhibited human acetylcholinesterase and butyrylcholinesterase. Oximes 9-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-111 19586353-0 2009 In vitro oxime-assisted reactivation of paraoxon-inhibited human acetylcholinesterase and butyrylcholinesterase. Paraoxon 40-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-111 19586353-1 2009 INTRODUCTION: Organophosphorus pesticides and nerve agents are highly toxic to humans and other living organisms, primarily because of their interaction with enzyme acetylcholinesterase. organophosphorus 14-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-185 19586353-3 2009 METHODS: Eighteen structurally different oxime reactivators were tested for their in vitro ability to reactivate paraoxon-inhibited human erythrocyte acetylcholinesterase and human plasma butyrylcholinesterase to find out structure-activity relationship within this set of compounds. Oximes 41-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 19586353-3 2009 METHODS: Eighteen structurally different oxime reactivators were tested for their in vitro ability to reactivate paraoxon-inhibited human erythrocyte acetylcholinesterase and human plasma butyrylcholinesterase to find out structure-activity relationship within this set of compounds. Paraoxon 113-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 19351555-0 2009 Acetylcholinesterase and butyrylcholinesterase inhibition of ethanolic extract and monoterpenes from Pimpinella anisoides V Brig. Monoterpenes 83-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 19351555-2 2009 Ethanolic extract from the fruits of Pimpinella anisoides, an aromatic plant and a spice, exhibited activity against AChE and BChE, with IC(50) values of 227.5 and 362.1 microg/ml, respectively. pimpinella anisoides 37-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 19351555-4 2009 trans-Anethole exhibited the highest activity against AChE and BChE with IC(50) values of 134.7 and 209.6 microg/ml, respectively. anethole 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 19351555-5 2009 The bicyclic monoterpene (+)-sabinene exhibited a promising activity against AChE (IC(50) of 176.5 microg/ml) and BChE (IC(50) of 218.6 microg/ml). Monoterpenes 13-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 19351555-5 2009 The bicyclic monoterpene (+)-sabinene exhibited a promising activity against AChE (IC(50) of 176.5 microg/ml) and BChE (IC(50) of 218.6 microg/ml). sabinene 25-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 19148665-3 2009 An 80-year-old woman died of an intoxication with methiocarb (mercaptodimethur), a carbamate type pesticide and as such a reversible inhibitor of the acetylcholinesterase. Methiocarb 50-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 19148665-3 2009 An 80-year-old woman died of an intoxication with methiocarb (mercaptodimethur), a carbamate type pesticide and as such a reversible inhibitor of the acetylcholinesterase. Methiocarb 62-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 19286462-0 2009 Quantitative analysis of donepezil binding to acetylcholinesterase using positron emission tomography and [5-(11)C-methoxy]donepezil. Donepezil 25-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 19286462-0 2009 Quantitative analysis of donepezil binding to acetylcholinesterase using positron emission tomography and [5-(11)C-methoxy]donepezil. (5-methoxy)donepezil 106-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 19286462-1 2009 The aim of this study was to establish kinetic analysis of [5-(11)C-methoxy]donepezil ([(11)C]donepezil), which was developed for the in-vivo visualization of donepezil binding to acetylcholinesterase (AChE) using positron emission tomography (PET). (5-methoxy)donepezil 59-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-200 19286462-1 2009 The aim of this study was to establish kinetic analysis of [5-(11)C-methoxy]donepezil ([(11)C]donepezil), which was developed for the in-vivo visualization of donepezil binding to acetylcholinesterase (AChE) using positron emission tomography (PET). (5-methoxy)donepezil 59-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-206 19286462-1 2009 The aim of this study was to establish kinetic analysis of [5-(11)C-methoxy]donepezil ([(11)C]donepezil), which was developed for the in-vivo visualization of donepezil binding to acetylcholinesterase (AChE) using positron emission tomography (PET). Donepezil 76-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-200 19286462-1 2009 The aim of this study was to establish kinetic analysis of [5-(11)C-methoxy]donepezil ([(11)C]donepezil), which was developed for the in-vivo visualization of donepezil binding to acetylcholinesterase (AChE) using positron emission tomography (PET). Donepezil 76-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-206 19286462-1 2009 The aim of this study was to establish kinetic analysis of [5-(11)C-methoxy]donepezil ([(11)C]donepezil), which was developed for the in-vivo visualization of donepezil binding to acetylcholinesterase (AChE) using positron emission tomography (PET). Donepezil 94-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-200 19286462-1 2009 The aim of this study was to establish kinetic analysis of [5-(11)C-methoxy]donepezil ([(11)C]donepezil), which was developed for the in-vivo visualization of donepezil binding to acetylcholinesterase (AChE) using positron emission tomography (PET). Donepezil 94-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-206 19286462-2 2009 Donepezil is an AChE inhibitor that is widely prescribed to ameliorate the cognitive impairment of patients with dementia. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 19526299-1 2009 Recently, several experimental K-oximes with two functional aldoxime groups have been synthesized that show excellent in vitro efficacy in protecting acetylcholinesterase (AChE) from inhibition by a broad variety of organophosphorus compounds (OPCs). k-oximes 31-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 19526299-1 2009 Recently, several experimental K-oximes with two functional aldoxime groups have been synthesized that show excellent in vitro efficacy in protecting acetylcholinesterase (AChE) from inhibition by a broad variety of organophosphorus compounds (OPCs). k-oximes 31-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-176 19526299-1 2009 Recently, several experimental K-oximes with two functional aldoxime groups have been synthesized that show excellent in vitro efficacy in protecting acetylcholinesterase (AChE) from inhibition by a broad variety of organophosphorus compounds (OPCs). Organophosphorus Compounds 216-242 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 19526299-1 2009 Recently, several experimental K-oximes with two functional aldoxime groups have been synthesized that show excellent in vitro efficacy in protecting acetylcholinesterase (AChE) from inhibition by a broad variety of organophosphorus compounds (OPCs). Organophosphorus Compounds 216-242 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-176 19526299-1 2009 Recently, several experimental K-oximes with two functional aldoxime groups have been synthesized that show excellent in vitro efficacy in protecting acetylcholinesterase (AChE) from inhibition by a broad variety of organophosphorus compounds (OPCs). Organophosphorus Compounds 244-248 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 19526299-1 2009 Recently, several experimental K-oximes with two functional aldoxime groups have been synthesized that show excellent in vitro efficacy in protecting acetylcholinesterase (AChE) from inhibition by a broad variety of organophosphorus compounds (OPCs). Organophosphorus Compounds 244-248 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-176 19526299-2 2009 However, oximes themselves are also AChE inhibitors, albeit at higher concentrations, which is a major cause of their toxicity and may be a dose-limiting factor in oxime therapy. Oximes 9-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 19526299-2 2009 However, oximes themselves are also AChE inhibitors, albeit at higher concentrations, which is a major cause of their toxicity and may be a dose-limiting factor in oxime therapy. Oximes 9-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 20387632-0 2009 [Hydrogen peroxide inhibits acetylcholinesterase of myometrium sarcolemma]. Hydrogen Peroxide 1-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 20387632-1 2009 The action of hydrogen peroxide on acetylcholinesterase enzymatic activity in myometrium sarcolemma fraction is investigated. Hydrogen Peroxide 14-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 20387632-3 2009 Acetylcholinesterase proved to be highly sensitive to the action of H2O2, making Ki = 2.4 +/- 0.4 microM, nH = 0.65 +/- 0.08 (n = 4-5). Hydrogen Peroxide 68-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 19564902-8 2009 Pralidoxime produced substantial and moderate red cell acetylcholinesterase reactivation in patients poisoned by diethyl and dimethyl compounds, respectively. pralidoxime 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 19564902-8 2009 Pralidoxime produced substantial and moderate red cell acetylcholinesterase reactivation in patients poisoned by diethyl and dimethyl compounds, respectively. diethyl and 113-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 19564902-8 2009 Pralidoxime produced substantial and moderate red cell acetylcholinesterase reactivation in patients poisoned by diethyl and dimethyl compounds, respectively. dimethyl compounds 125-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 19564902-10 2009 Incorporating the baseline amount of acetylcholinesterase already aged and plasma OP concentration into the analysis increased the HR for patients receiving pralidoxime compared to placebo, further decreasing the likelihood that pralidoxime is beneficial. pralidoxime 157-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 19564902-10 2009 Incorporating the baseline amount of acetylcholinesterase already aged and plasma OP concentration into the analysis increased the HR for patients receiving pralidoxime compared to placebo, further decreasing the likelihood that pralidoxime is beneficial. pralidoxime 229-240 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 19564902-13 2009 CONCLUSIONS: Despite clear reactivation of red cell acetylcholinesterase in diethyl organophosphorus pesticide poisoned patients, we found no evidence that this regimen improves survival or reduces need for intubation in patients with organophosphorus insecticide poisoning. diethyl organophosphorus 76-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 19564902-13 2009 CONCLUSIONS: Despite clear reactivation of red cell acetylcholinesterase in diethyl organophosphorus pesticide poisoned patients, we found no evidence that this regimen improves survival or reduces need for intubation in patients with organophosphorus insecticide poisoning. organophosphorus 84-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 19449818-4 2009 We have concluded that oximes reactivate AChE by a three-step mechanism in opposition to the four-step processes of the other modeled nucleophiles. Oximes 23-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 19449818-5 2009 In addition, our model suggests that oximes react with AChE in the deprotonated form (oximate). Oximes 37-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 19536291-1 2009 Organophosphonates such as isopropyl metylphosphonofluoridate (sarin) are extremely toxic as they phosphonylate the catalytic serine residue of acetylcholinesterase (AChE), an enzyme essential to humans and other species. Organophosphonates 0-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-164 19536291-1 2009 Organophosphonates such as isopropyl metylphosphonofluoridate (sarin) are extremely toxic as they phosphonylate the catalytic serine residue of acetylcholinesterase (AChE), an enzyme essential to humans and other species. Organophosphonates 0-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 19536291-1 2009 Organophosphonates such as isopropyl metylphosphonofluoridate (sarin) are extremely toxic as they phosphonylate the catalytic serine residue of acetylcholinesterase (AChE), an enzyme essential to humans and other species. isopropyl metylphosphonofluoridate 27-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-164 19536291-1 2009 Organophosphonates such as isopropyl metylphosphonofluoridate (sarin) are extremely toxic as they phosphonylate the catalytic serine residue of acetylcholinesterase (AChE), an enzyme essential to humans and other species. isopropyl metylphosphonofluoridate 27-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 19536291-1 2009 Organophosphonates such as isopropyl metylphosphonofluoridate (sarin) are extremely toxic as they phosphonylate the catalytic serine residue of acetylcholinesterase (AChE), an enzyme essential to humans and other species. Sarin 63-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-164 19536291-1 2009 Organophosphonates such as isopropyl metylphosphonofluoridate (sarin) are extremely toxic as they phosphonylate the catalytic serine residue of acetylcholinesterase (AChE), an enzyme essential to humans and other species. Sarin 63-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 19536291-1 2009 Organophosphonates such as isopropyl metylphosphonofluoridate (sarin) are extremely toxic as they phosphonylate the catalytic serine residue of acetylcholinesterase (AChE), an enzyme essential to humans and other species. Serine 126-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-164 19536291-1 2009 Organophosphonates such as isopropyl metylphosphonofluoridate (sarin) are extremely toxic as they phosphonylate the catalytic serine residue of acetylcholinesterase (AChE), an enzyme essential to humans and other species. Serine 126-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 19536291-2 2009 Design of effective AChE reactivators as antidotes to various organophosphonates requires information on how the reactivators interact with the phosphonylated AChEs. Organophosphonates 62-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 19446058-2 2009 The acetylcholinesterase enzyme (AChE) was immobilized by adsorption into the nanostructured PbO2/TiO2/Ti, which also acted as the working electrode. titanium dioxide 98-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-31 19446058-2 2009 The acetylcholinesterase enzyme (AChE) was immobilized by adsorption into the nanostructured PbO2/TiO2/Ti, which also acted as the working electrode. titanium dioxide 98-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 19446058-3 2009 This strategy was found to catalyze the oxidative reaction of thiocholine effectively, make the AChE/PbO2/TiO2/Ti biosensor detect the substrate at 0.30 V (vs. SCE), hundreds milli-volts lower than others reported. Thiocholine 62-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 19446058-3 2009 This strategy was found to catalyze the oxidative reaction of thiocholine effectively, make the AChE/PbO2/TiO2/Ti biosensor detect the substrate at 0.30 V (vs. SCE), hundreds milli-volts lower than others reported. titanium dioxide 106-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 19194797-0 2009 Protection of PMS777, a new AChE inhibitor with PAF antagonism, against amyloid-beta-induced neuronal apoptosis and neuroinflammation. PMS 777 14-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 19194797-2 2009 In the previous study, we reported that PMS777, a novel bis-interacting ligand for acetylcholinesterase (AChE) inhibition and platelet-activating factor (PAF) receptor antagonism, could significantly attenuate PAF-induced neurotoxicity. PMS 777 40-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 19665386-1 2009 A series of fluorinated oxime compounds was designed and synthesized in order to probe the effect of fluorine substitution on reactivation of inhibited acetylcholinesterase (AChE) by organophosphorus agents. fluorinated oxime 12-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 19665386-1 2009 A series of fluorinated oxime compounds was designed and synthesized in order to probe the effect of fluorine substitution on reactivation of inhibited acetylcholinesterase (AChE) by organophosphorus agents. fluorinated oxime 12-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 19665386-1 2009 A series of fluorinated oxime compounds was designed and synthesized in order to probe the effect of fluorine substitution on reactivation of inhibited acetylcholinesterase (AChE) by organophosphorus agents. Fluorine 101-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 19665386-1 2009 A series of fluorinated oxime compounds was designed and synthesized in order to probe the effect of fluorine substitution on reactivation of inhibited acetylcholinesterase (AChE) by organophosphorus agents. Fluorine 101-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 19665386-3 2009 Among the compounds explored in this study, the mono-fluorinated carbamoyl aldoxime 4b was the most potent reactivator for paraoxon-inhibited red blood cell (RBC) AChE. carbamoyl aldoxime 4b 65-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 19665386-3 2009 Among the compounds explored in this study, the mono-fluorinated carbamoyl aldoxime 4b was the most potent reactivator for paraoxon-inhibited red blood cell (RBC) AChE. Paraoxon 123-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 19622237-1 2009 The green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) was investigated for its enhancement effect of huperzine A on inhibiting acetylcholinesterase (AChE). polyphenol (-)-epigallocatechin-3-gallate 14-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 19622237-1 2009 The green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) was investigated for its enhancement effect of huperzine A on inhibiting acetylcholinesterase (AChE). epigallocatechin gallate 57-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 19622237-1 2009 The green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) was investigated for its enhancement effect of huperzine A on inhibiting acetylcholinesterase (AChE). huperzine A 110-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 19622237-3 2009 EGCG hardly inhibits the AChE activity within the range 10-300 mg/kg. epigallocatechin gallate 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 19485411-2 2009 The novel prochelator HLA20A with improved cytotoxicity shows little affinity for metal ions until it is activated by binding and inhibiting acetylcholinesterase (AChE), releasing an active chelator HLA20 that modulates amyloid precursor protein (APP) regulation and beta-amyloid (Abeta) reduction, suppresses oxidative stress, and passivates excess metal ions (Fe, Cu, and Zn) in the brain. Metals 350-355 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 19485411-2 2009 The novel prochelator HLA20A with improved cytotoxicity shows little affinity for metal ions until it is activated by binding and inhibiting acetylcholinesterase (AChE), releasing an active chelator HLA20 that modulates amyloid precursor protein (APP) regulation and beta-amyloid (Abeta) reduction, suppresses oxidative stress, and passivates excess metal ions (Fe, Cu, and Zn) in the brain. Metals 350-355 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 19485411-2 2009 The novel prochelator HLA20A with improved cytotoxicity shows little affinity for metal ions until it is activated by binding and inhibiting acetylcholinesterase (AChE), releasing an active chelator HLA20 that modulates amyloid precursor protein (APP) regulation and beta-amyloid (Abeta) reduction, suppresses oxidative stress, and passivates excess metal ions (Fe, Cu, and Zn) in the brain. Iron 362-364 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 19485411-2 2009 The novel prochelator HLA20A with improved cytotoxicity shows little affinity for metal ions until it is activated by binding and inhibiting acetylcholinesterase (AChE), releasing an active chelator HLA20 that modulates amyloid precursor protein (APP) regulation and beta-amyloid (Abeta) reduction, suppresses oxidative stress, and passivates excess metal ions (Fe, Cu, and Zn) in the brain. Iron 362-364 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 19485411-2 2009 The novel prochelator HLA20A with improved cytotoxicity shows little affinity for metal ions until it is activated by binding and inhibiting acetylcholinesterase (AChE), releasing an active chelator HLA20 that modulates amyloid precursor protein (APP) regulation and beta-amyloid (Abeta) reduction, suppresses oxidative stress, and passivates excess metal ions (Fe, Cu, and Zn) in the brain. Copper 366-368 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 19485411-2 2009 The novel prochelator HLA20A with improved cytotoxicity shows little affinity for metal ions until it is activated by binding and inhibiting acetylcholinesterase (AChE), releasing an active chelator HLA20 that modulates amyloid precursor protein (APP) regulation and beta-amyloid (Abeta) reduction, suppresses oxidative stress, and passivates excess metal ions (Fe, Cu, and Zn) in the brain. Copper 366-368 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 19485411-2 2009 The novel prochelator HLA20A with improved cytotoxicity shows little affinity for metal ions until it is activated by binding and inhibiting acetylcholinesterase (AChE), releasing an active chelator HLA20 that modulates amyloid precursor protein (APP) regulation and beta-amyloid (Abeta) reduction, suppresses oxidative stress, and passivates excess metal ions (Fe, Cu, and Zn) in the brain. Zinc 374-376 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 19485411-2 2009 The novel prochelator HLA20A with improved cytotoxicity shows little affinity for metal ions until it is activated by binding and inhibiting acetylcholinesterase (AChE), releasing an active chelator HLA20 that modulates amyloid precursor protein (APP) regulation and beta-amyloid (Abeta) reduction, suppresses oxidative stress, and passivates excess metal ions (Fe, Cu, and Zn) in the brain. Zinc 374-376 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 19492815-2 2009 As an example, the detection of acetylcholinesterase (AChE) inhibitors such as neurotoxins and organophosphates has implications for neuroscience, drug assessment, pharmaceutical development, and environmental monitoring. Organophosphates 95-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 19492815-2 2009 As an example, the detection of acetylcholinesterase (AChE) inhibitors such as neurotoxins and organophosphates has implications for neuroscience, drug assessment, pharmaceutical development, and environmental monitoring. Organophosphates 95-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 19492815-6 2009 AChE inhibitors, including paraoxon and aflatoxin B1, were detected successfully using this sensor by measuring the residual activity of AChE on paper, using Ellman"s colorimetric assay, with capture of the 5-thio-2-nitrobenzoate (TNB(-)) product on the PVAm layer. Paraoxon 27-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 19492815-6 2009 AChE inhibitors, including paraoxon and aflatoxin B1, were detected successfully using this sensor by measuring the residual activity of AChE on paper, using Ellman"s colorimetric assay, with capture of the 5-thio-2-nitrobenzoate (TNB(-)) product on the PVAm layer. Paraoxon 27-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 19492815-6 2009 AChE inhibitors, including paraoxon and aflatoxin B1, were detected successfully using this sensor by measuring the residual activity of AChE on paper, using Ellman"s colorimetric assay, with capture of the 5-thio-2-nitrobenzoate (TNB(-)) product on the PVAm layer. Aflatoxin B1 40-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 19492815-6 2009 AChE inhibitors, including paraoxon and aflatoxin B1, were detected successfully using this sensor by measuring the residual activity of AChE on paper, using Ellman"s colorimetric assay, with capture of the 5-thio-2-nitrobenzoate (TNB(-)) product on the PVAm layer. Aflatoxin B1 40-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 19492815-6 2009 AChE inhibitors, including paraoxon and aflatoxin B1, were detected successfully using this sensor by measuring the residual activity of AChE on paper, using Ellman"s colorimetric assay, with capture of the 5-thio-2-nitrobenzoate (TNB(-)) product on the PVAm layer. 5-thio-2-nitrobenzoate 207-229 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 19473849-0 2009 Synthesis and structure-activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors. huprine 49-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 19473849-1 2009 New series of Huprine (12-amino-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinolines) derivatives have been synthesized and their inhibiting activities toward recombinant human acetylcholinesterase (rh-AChE) are reported. huprine 14-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-200 19473849-1 2009 New series of Huprine (12-amino-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinolines) derivatives have been synthesized and their inhibiting activities toward recombinant human acetylcholinesterase (rh-AChE) are reported. huprine 14-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 205-209 19473849-1 2009 New series of Huprine (12-amino-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinolines) derivatives have been synthesized and their inhibiting activities toward recombinant human acetylcholinesterase (rh-AChE) are reported. 12-amino-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinolines 23-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-200 19473849-1 2009 New series of Huprine (12-amino-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinolines) derivatives have been synthesized and their inhibiting activities toward recombinant human acetylcholinesterase (rh-AChE) are reported. 12-amino-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinolines 23-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 205-209 19449818-1 2009 Oximes have been used as reactivators for organophosphorus-inhibited acetylcholinesterase (AChE). Oximes 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 18780301-0 2009 Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer"s disease and relationships with response to treatment with Donepezil and Rivastigmine. Donepezil 138-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 18780301-0 2009 Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer"s disease and relationships with response to treatment with Donepezil and Rivastigmine. Rivastigmine 152-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 18780301-9 2009 Carrying an allele or a genotype of these SNPs does not seem to play a relevant role in the response to treatment with the two cholinesterase inhibitors, though some significant results were found associated with the AChE A/A genotype that had the best response when treated with Rivastigmine. Rivastigmine 280-292 acetylcholinesterase (Cartwright blood group) Homo sapiens 217-221 19435302-1 2009 The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP). Isoleucine 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 19435302-1 2009 The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP). Isoleucine 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 19435302-1 2009 The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP). Isoleucine 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 19435302-1 2009 The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP). Phenylalanine 23-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 19435302-1 2009 The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP). Phenylalanine 23-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 19435302-1 2009 The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP). Phenylalanine 23-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 19435302-1 2009 The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP). Arginine 28-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 19435302-1 2009 The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP). Arginine 28-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 19435302-1 2009 The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP). Arginine 28-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 19435302-1 2009 The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP). Phenylalanine 37-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 19435302-1 2009 The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP). Phenylalanine 37-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 19435302-1 2009 The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP). Phenylalanine 37-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 19435302-1 2009 The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP). Isoflurophate 137-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 19435302-1 2009 The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP). Isoflurophate 137-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 19435302-1 2009 The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP). Isoflurophate 137-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 19435302-1 2009 The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP). Isoflurophate 169-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 19435302-1 2009 The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP). Isoflurophate 169-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 19435302-1 2009 The loop 287-290 (Ile, Phe, Arg, and Phe) of the protein acetylcholinesterase (AChE) changes its structure upon interaction of AChE with diisopropylphosphorofluoridate (DFP). Isoflurophate 169-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 19374428-1 2009 A new convenient and continuous fluorometric assay method for acetylcholinesterase (AChE) and its inhibitor screening is successfully established with the ensemble of 1 [a TPE (tetraphenylethylene) compound with two sulfonate (-SO(3)(-)) units] and myristoylcholine (an amphiphilic compound as a good substrate of AChE). tetraphenylethylene 177-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 19374428-1 2009 A new convenient and continuous fluorometric assay method for acetylcholinesterase (AChE) and its inhibitor screening is successfully established with the ensemble of 1 [a TPE (tetraphenylethylene) compound with two sulfonate (-SO(3)(-)) units] and myristoylcholine (an amphiphilic compound as a good substrate of AChE). tetraphenylethylene 177-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 19374428-1 2009 A new convenient and continuous fluorometric assay method for acetylcholinesterase (AChE) and its inhibitor screening is successfully established with the ensemble of 1 [a TPE (tetraphenylethylene) compound with two sulfonate (-SO(3)(-)) units] and myristoylcholine (an amphiphilic compound as a good substrate of AChE). sulfonate 216-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 19374428-1 2009 A new convenient and continuous fluorometric assay method for acetylcholinesterase (AChE) and its inhibitor screening is successfully established with the ensemble of 1 [a TPE (tetraphenylethylene) compound with two sulfonate (-SO(3)(-)) units] and myristoylcholine (an amphiphilic compound as a good substrate of AChE). sulfonate 216-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 19374428-1 2009 A new convenient and continuous fluorometric assay method for acetylcholinesterase (AChE) and its inhibitor screening is successfully established with the ensemble of 1 [a TPE (tetraphenylethylene) compound with two sulfonate (-SO(3)(-)) units] and myristoylcholine (an amphiphilic compound as a good substrate of AChE). sulfonate 216-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 314-318 19374428-1 2009 A new convenient and continuous fluorometric assay method for acetylcholinesterase (AChE) and its inhibitor screening is successfully established with the ensemble of 1 [a TPE (tetraphenylethylene) compound with two sulfonate (-SO(3)(-)) units] and myristoylcholine (an amphiphilic compound as a good substrate of AChE). myristoylcholine 249-265 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 19374428-1 2009 A new convenient and continuous fluorometric assay method for acetylcholinesterase (AChE) and its inhibitor screening is successfully established with the ensemble of 1 [a TPE (tetraphenylethylene) compound with two sulfonate (-SO(3)(-)) units] and myristoylcholine (an amphiphilic compound as a good substrate of AChE). myristoylcholine 249-265 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 19374428-5 2009 The results also clearly demonstrate the usefulness of this convenient assay method for kinetic study of AChE-catalyzed myristoylcholine hydrolysis and screening inhibitors of AChE. myristoylcholine 120-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 19374428-5 2009 The results also clearly demonstrate the usefulness of this convenient assay method for kinetic study of AChE-catalyzed myristoylcholine hydrolysis and screening inhibitors of AChE. myristoylcholine 120-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 19441865-1 2009 In view of the nonavailability of complete X-ray structure of carbamates cocrystallized with AChE enzyme, the 3D-QSAR model development based on cocrystallized conformer (CCBA) as well as docked conformer-based alignment (DCBA) is not feasible. Carbamates 62-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 18825528-3 2009 The presented study is aimed at reactivation of trichlorfon-inhibited butyrylcholinesterase since this enzyme play an important role in Alzheimer"s disease as deputy for acetylcholinesterase and furthermore it could be applied as a scavenger in case of overdosing. Trichlorfon 48-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-190 19429253-0 2009 Interaction of pentylsarin analogues with human acetylcholinesterase: a kinetic study. pentylsarin 15-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 19429253-1 2009 Previous kinetic studies investigating the interactions between human acetylcholinesterase (AChE), structurally different organophosphorus compounds (OP) and oximes did not reveal a conclusive structure-activity relationship of the different reactions. Oximes 158-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 19429253-4 2009 The rate constants for the inhibition of human erythrocyte AChE by four pentylsarin compounds (k(i)), for the spontaneous dealkylation (aging, k(a)) and reactivation (k(s)) of inhibited AChE as well as for the oxime-induced reactivation of inhibited AChE by obidoxime and HI 6 reflected by the dissociation constant (K(D)) and the reactivity constant (k(r)) were determined. pentylsarin 72-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 19429253-5 2009 All pentylsarin analogues had a high inhibitory potency towards AChE. pentylsarin 4-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 19429253-7 2009 Pentylsarin-inhibited AChE could be reactivated by oximes, HI 6 being more potent than obidoxime. pentylsarin 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 19429253-7 2009 Pentylsarin-inhibited AChE could be reactivated by oximes, HI 6 being more potent than obidoxime. Oximes 51-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 19429253-7 2009 Pentylsarin-inhibited AChE could be reactivated by oximes, HI 6 being more potent than obidoxime. asoxime chloride 59-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 19429253-7 2009 Pentylsarin-inhibited AChE could be reactivated by oximes, HI 6 being more potent than obidoxime. Obidoxime Chloride 87-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 19429253-8 2009 The determination of inhibition, reactivation and aging kinetics of pentylsarin analogues with human AChE extends the database on interactions between AChE and methylphosphonofluoridate homologues with C1-C4 n- and i-alkyl residues demonstrating a structure-activity relationship depending on the chain length with certain differences regarding inhibition and post-inhibitory reactions. pentylsarin 68-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 19429253-8 2009 The determination of inhibition, reactivation and aging kinetics of pentylsarin analogues with human AChE extends the database on interactions between AChE and methylphosphonofluoridate homologues with C1-C4 n- and i-alkyl residues demonstrating a structure-activity relationship depending on the chain length with certain differences regarding inhibition and post-inhibitory reactions. pentylsarin 68-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 19429253-8 2009 The determination of inhibition, reactivation and aging kinetics of pentylsarin analogues with human AChE extends the database on interactions between AChE and methylphosphonofluoridate homologues with C1-C4 n- and i-alkyl residues demonstrating a structure-activity relationship depending on the chain length with certain differences regarding inhibition and post-inhibitory reactions. methylphosphonofluoridate 160-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 19429253-9 2009 Unfortunately, no structure-activity relationship could be observed for the oxime-induced reactivation of inhibited AChE. Oximes 76-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 19532920-1 2009 The integration of Au-doped TiO(2) nanotubes with biomolecule acetylcholinesterase (AChE) yields a novel AChE-Au-TiO(2) hybrid system, which provides a new rapid and valid photoelectrochemical approach to the determination of AChE inhibition induced by endogenous neurotoxin. Gold 19-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 19532920-1 2009 The integration of Au-doped TiO(2) nanotubes with biomolecule acetylcholinesterase (AChE) yields a novel AChE-Au-TiO(2) hybrid system, which provides a new rapid and valid photoelectrochemical approach to the determination of AChE inhibition induced by endogenous neurotoxin. Gold 19-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 19532920-1 2009 The integration of Au-doped TiO(2) nanotubes with biomolecule acetylcholinesterase (AChE) yields a novel AChE-Au-TiO(2) hybrid system, which provides a new rapid and valid photoelectrochemical approach to the determination of AChE inhibition induced by endogenous neurotoxin. Gold 19-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 19532920-1 2009 The integration of Au-doped TiO(2) nanotubes with biomolecule acetylcholinesterase (AChE) yields a novel AChE-Au-TiO(2) hybrid system, which provides a new rapid and valid photoelectrochemical approach to the determination of AChE inhibition induced by endogenous neurotoxin. Gold 19-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 19532920-1 2009 The integration of Au-doped TiO(2) nanotubes with biomolecule acetylcholinesterase (AChE) yields a novel AChE-Au-TiO(2) hybrid system, which provides a new rapid and valid photoelectrochemical approach to the determination of AChE inhibition induced by endogenous neurotoxin. titanium dioxide 28-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 19532920-1 2009 The integration of Au-doped TiO(2) nanotubes with biomolecule acetylcholinesterase (AChE) yields a novel AChE-Au-TiO(2) hybrid system, which provides a new rapid and valid photoelectrochemical approach to the determination of AChE inhibition induced by endogenous neurotoxin. titanium dioxide 28-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 19532920-1 2009 The integration of Au-doped TiO(2) nanotubes with biomolecule acetylcholinesterase (AChE) yields a novel AChE-Au-TiO(2) hybrid system, which provides a new rapid and valid photoelectrochemical approach to the determination of AChE inhibition induced by endogenous neurotoxin. titanium dioxide 28-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 19532920-1 2009 The integration of Au-doped TiO(2) nanotubes with biomolecule acetylcholinesterase (AChE) yields a novel AChE-Au-TiO(2) hybrid system, which provides a new rapid and valid photoelectrochemical approach to the determination of AChE inhibition induced by endogenous neurotoxin. titanium dioxide 28-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 19269805-0 2009 Electrochemical biosensor for pesticides based on acetylcholinesterase immobilized on polyaniline deposited on vertically assembled carbon nanotubes wrapped with ssDNA. polyaniline 86-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 19269805-0 2009 Electrochemical biosensor for pesticides based on acetylcholinesterase immobilized on polyaniline deposited on vertically assembled carbon nanotubes wrapped with ssDNA. Carbon 132-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 19269805-2 2009 The self-assembled monolayers (SAMs) of single walled carbon nanotubes (SWCNT) wrapped by thiol terminated single strand oligonucleotide (ssDNA) on gold was utilized to prepare nano size polyaniline matrix for acetylcholinesterase (AChE) enzyme immobilization. Oligonucleotides 121-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-230 19269805-2 2009 The self-assembled monolayers (SAMs) of single walled carbon nanotubes (SWCNT) wrapped by thiol terminated single strand oligonucleotide (ssDNA) on gold was utilized to prepare nano size polyaniline matrix for acetylcholinesterase (AChE) enzyme immobilization. polyaniline 187-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-230 19269805-2 2009 The self-assembled monolayers (SAMs) of single walled carbon nanotubes (SWCNT) wrapped by thiol terminated single strand oligonucleotide (ssDNA) on gold was utilized to prepare nano size polyaniline matrix for acetylcholinesterase (AChE) enzyme immobilization. polyaniline 187-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 232-236 19269805-3 2009 The key step of this biosensor was AChE-acetylcholine enzymatic reaction which causes the small changes of local pH in the vicinity of an electrode surface. Acetylcholine 40-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 19428953-3 2009 A mainstay of standard antidotal treatment is atropine for antagonizing effects mediated by over stimulation of muscarinic ACh-receptors and oxime to reactivate OP-inhibited AChE. Atropine 46-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 19428953-4 2009 For therapeutic monitoring of oxime treatment in OP poisoning, measurement of erythrocyte AChE is suitable because erythrocyte AChE is an easily accessible surrogate for synaptic AChE. Oximes 30-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 19269469-1 2009 The article presents a novel strategy for a sensitive investigation of the interaction between acetylcholinesterase (AChE) and its small molecular carbamate inhibitors. Carbamates 147-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 19269469-1 2009 The article presents a novel strategy for a sensitive investigation of the interaction between acetylcholinesterase (AChE) and its small molecular carbamate inhibitors. Carbamates 147-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 19269469-3 2009 With the signal amplification of AuNPs, the specific interactions between the AuNPs labeled carbamate inhibitors (ALC1 and ALC2) and the immobilized AChE on sensor chip surface were readily examined. Carbamates 92-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 19269469-5 2009 The association/dissociation constants for the binding interaction between carbamate inhibitors and AChE were reported for the first time. Carbamates 75-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 19374444-1 2009 Tacripyrines (1-14) have been designed by combining an AChE inhibitor (tacrine) with a calcium antagonist such as nimodipine and are targeted to develop a multitarget therapeutic strategy to confront AD. tacripyrines 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 19374444-1 2009 Tacripyrines (1-14) have been designed by combining an AChE inhibitor (tacrine) with a calcium antagonist such as nimodipine and are targeted to develop a multitarget therapeutic strategy to confront AD. Tacrine 71-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 19374444-2 2009 Tacripyrines are selective and potent AChE inhibitors in the nanomolar range. tacripyrines 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 19374444-4 2009 Molecular modeling indicates that binding of compound 11 to the AChE PAS mainly involves the (R)-11 enantiomer, which also agrees with the noncompetitive inhibition mechanism exhibited by p-methoxytacripyrine 11. p-methoxytacripyrine 188-208 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 19388874-3 2009 Donepezil is a drug that been proven to be effective in the treatment of dementia, including Alzheimer"s; it has been used for affective disorders and its mechanism of action is to inhibit the acetylcholinesterase enzyme to increase acetylcholine. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-213 19428464-0 2009 Immobilization of acetylcholinesterase on nanostructure polyacrylonitrile membranes. polyacrylonitrile 56-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 19428464-6 2009 AChE was covalently immobilized onto nanostructured membranes using 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide hydrochloride. 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride 68-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 19238297-4 2009 The PQQ electrode was then utilized as a thiol-specific sensor for the real-time monitoring of thiocholine generated from the hydrolysis of acetylthiocholine (ASCh) by acetylcholinesterase (AChE). Sulfhydryl Compounds 41-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-188 19051205-9 2009 The non-catalytic antibodies, AE-2 and the Ab2, recognized AChE"s peripheral anionic site (PAS), in particular, the sequence (70)YQYVD, which contains two of the site"s residues. Aminosalicylic Acid 91-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 19416629-6 2009 In addition, McN-A-343, by activating the facilitatory M(1) receptors and physostigmine by inhibiting the acetylcholinesterase may induce the release of this factor through endogenous acetylcholine in the coaxial bioassay system. Physostigmine 74-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 19428926-1 2009 Recently, a dynamically working in vitro model with real-time determination of membrane-bound human acetylcholinesterase (AChE) activity was shown to be a versatile model to investigate oxime-induced reactivation kinetics of organophosphate- (OP) inhibited enzyme. Oximes 186-191 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 19428926-1 2009 Recently, a dynamically working in vitro model with real-time determination of membrane-bound human acetylcholinesterase (AChE) activity was shown to be a versatile model to investigate oxime-induced reactivation kinetics of organophosphate- (OP) inhibited enzyme. Organophosphates 225-240 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 19428926-7 2009 Hence, this dynamic model offers the possibility to investigate highly reproducible interactions between AChE, OP and oximes with human and animal AChE. Oximes 118-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 19380700-6 2009 [11C]methyl-4-piperidinyl propionate AChE PET imaging was used to assess cortical AChE activity. Carbon-11 1-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 19380700-6 2009 [11C]methyl-4-piperidinyl propionate AChE PET imaging was used to assess cortical AChE activity. methyl-4-piperidinyl propionate 5-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 19135350-0 2009 EQCM immunoassay for phosphorylated acetylcholinesterase as a biomarker for organophosphate exposures based on selective zirconia adsorption and enzyme-catalytic precipitation. Organophosphates 76-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 19135350-0 2009 EQCM immunoassay for phosphorylated acetylcholinesterase as a biomarker for organophosphate exposures based on selective zirconia adsorption and enzyme-catalytic precipitation. zirconium oxide 121-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 19135350-1 2009 A zirconia (ZrO(2)) adsorption-based immunoassay by electrochemical quartz crystal microbalance (EQCM) has been initially developed, aiming at the detection of phosphorylated acetylcholinesterase (Phospho-AChE) as a potential biomarker for bio-monitoring exposures to organophosphate (OP) pesticides and chemical warfare agents. zro(2) 12-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 175-195 19135350-1 2009 A zirconia (ZrO(2)) adsorption-based immunoassay by electrochemical quartz crystal microbalance (EQCM) has been initially developed, aiming at the detection of phosphorylated acetylcholinesterase (Phospho-AChE) as a potential biomarker for bio-monitoring exposures to organophosphate (OP) pesticides and chemical warfare agents. zro(2) 12-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 205-209 19135350-3 2009 The resulting ZrO(2) film was utilized to selectively capture Phospho-AChE from the sample media. zro(2) 14-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 19368807-0 2009 Transcriptional regulation of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase in neuron: an inductive effect of neuron differentiation. Proline 30-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 19368807-1 2009 The transcriptional regulation of proline-rich membrane anchor (PRiMA), an anchoring protein of tetrameric globular form of acetylcholinesterase (G(4) AChE), was revealed in cultured cortical neurons during differentiation. Proline 34-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 19368807-1 2009 The transcriptional regulation of proline-rich membrane anchor (PRiMA), an anchoring protein of tetrameric globular form of acetylcholinesterase (G(4) AChE), was revealed in cultured cortical neurons during differentiation. Proline 34-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 19222043-0 2009 Structure-activity relationships and binding mode in the human acetylcholinesterase active site of pseudo-irreversible inhibitors related to xanthostigmine. xanthostigmine 141-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 19222043-1 2009 Structure-activity relationship studies on acetylcholinesterase (AChE) inhibitors were extended to newly synthesized compounds derived from the lead compound xantostigmine (1). xantostigmine 158-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 19222043-1 2009 Structure-activity relationship studies on acetylcholinesterase (AChE) inhibitors were extended to newly synthesized compounds derived from the lead compound xantostigmine (1). xantostigmine 158-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 19292875-0 2009 Hydrolysis of acetylthiocoline, o-nitroacetanilide and o-nitrotrifluoroacetanilide by fetal bovine serum acetylcholinesterase. acetylthiocoline 14-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 19292875-0 2009 Hydrolysis of acetylthiocoline, o-nitroacetanilide and o-nitrotrifluoroacetanilide by fetal bovine serum acetylcholinesterase. 2-nitroacetanilide 32-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 19292875-0 2009 Hydrolysis of acetylthiocoline, o-nitroacetanilide and o-nitrotrifluoroacetanilide by fetal bovine serum acetylcholinesterase. 2-nitrotrifluoroacetanilide 55-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 19292875-1 2009 Besides esterase activity, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) hydrolyze o-nitroacetanilides through aryl acylamidase activity. 2-nitroacetanilide 99-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 19292875-1 2009 Besides esterase activity, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) hydrolyze o-nitroacetanilides through aryl acylamidase activity. 2-nitroacetanilide 99-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 18825527-0 2009 Acetylcholinesterase/butyrylcholinesterase inhibition activity of some new carbacylamidophosphate derivatives. carbacylamidophosphate 75-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 18830885-0 2009 Synthesis and biological evaluation of novel flavonoid derivatives as dual binding acetylcholinesterase inhibitors. Flavonoids 45-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 18830885-1 2009 A new series of flavonoid derivatives have been designed, synthesised and evaluated as acetylcholinesterase inhibitors that could bind simultaneously to the peripheral and catalytic sites of the enzyme. Flavonoids 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 18830885-4 2009 Preliminary structure-activity relationships and a molecular modeling study for 9a have revealed that the isoflavone moiety plays a key role in the interaction of this series of derivatives with AChE by acting as an anchor in its peripheral anionic site. Isoflavones 106-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 19437977-0 2009 Acetylcholinesterase biosensor based on gold nanoparticles and cysteamine self assembled monolayer for determination of monocrotophos. Cysteamine 63-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 19437977-1 2009 In this paper, a simple method for immobilization of acetylcholinesterase (AChE) on cysteamine assembled glassy carbon electrode coupled with gold nanoparticles (GNPs) was proposed and thus a sensitive, fast and stable amperometric biosensor for quantitative determination of monocrotophos was developed. Cysteamine 84-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 19437977-1 2009 In this paper, a simple method for immobilization of acetylcholinesterase (AChE) on cysteamine assembled glassy carbon electrode coupled with gold nanoparticles (GNPs) was proposed and thus a sensitive, fast and stable amperometric biosensor for quantitative determination of monocrotophos was developed. Cysteamine 84-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 19437977-1 2009 In this paper, a simple method for immobilization of acetylcholinesterase (AChE) on cysteamine assembled glassy carbon electrode coupled with gold nanoparticles (GNPs) was proposed and thus a sensitive, fast and stable amperometric biosensor for quantitative determination of monocrotophos was developed. Carbon 112-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 19437977-1 2009 In this paper, a simple method for immobilization of acetylcholinesterase (AChE) on cysteamine assembled glassy carbon electrode coupled with gold nanoparticles (GNPs) was proposed and thus a sensitive, fast and stable amperometric biosensor for quantitative determination of monocrotophos was developed. Carbon 112-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 19371631-0 2009 Toxicodynamic analysis of the inhibition of isolated human acetylcholinesterase by combinations of methamidophos and methomyl in vitro. methamidophos 99-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 19371631-2 2009 In the present study, the inhibition of AChE by combinations of methamidophos (an OP-ester) and methomyl (a carbamate) was examined in vitro. methamidophos 64-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 19371631-2 2009 In the present study, the inhibition of AChE by combinations of methamidophos (an OP-ester) and methomyl (a carbamate) was examined in vitro. op-ester 82-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 19371631-2 2009 In the present study, the inhibition of AChE by combinations of methamidophos (an OP-ester) and methomyl (a carbamate) was examined in vitro. Methomyl 96-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 19371631-2 2009 In the present study, the inhibition of AChE by combinations of methamidophos (an OP-ester) and methomyl (a carbamate) was examined in vitro. Carbamates 108-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 19472276-2 2009 The progress of the enzymatic reaction of the hydrolysis of acetylthiocholine at pH 8 in the presence of AChE and the inhibitor studied is determined by measuring at 230 nm the peak area of the reaction product thiocholine (TCh). Acetylthiocholine 60-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 19472276-2 2009 The progress of the enzymatic reaction of the hydrolysis of acetylthiocholine at pH 8 in the presence of AChE and the inhibitor studied is determined by measuring at 230 nm the peak area of the reaction product thiocholine (TCh). Thiocholine 66-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 19472276-2 2009 The progress of the enzymatic reaction of the hydrolysis of acetylthiocholine at pH 8 in the presence of AChE and the inhibitor studied is determined by measuring at 230 nm the peak area of the reaction product thiocholine (TCh). Thiocholine 224-227 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 19221692-0 2009 Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer"s disease: an updated meta-analysis. huperzine A 62-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 19111456-0 2009 Electrochemical biosensing of methyl parathion pesticide based on acetylcholinesterase immobilized onto Au-polypyrrole interlaced network-like nanocomposite. Methyl Parathion 30-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 19111456-0 2009 Electrochemical biosensing of methyl parathion pesticide based on acetylcholinesterase immobilized onto Au-polypyrrole interlaced network-like nanocomposite. au-polypyrrole 104-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 19111456-1 2009 We developed a simple strategy for designing a highly sensitive electrochemical biosensor for organophosphate pesticides (OPs) based on acetylcholinesterase (AChE) immobilized onto Au nanoparticles-polypyrrole nanowires composite film modifid glassy carbon electrode (labeled as AChE-Au-PPy/GCE). Organophosphates 94-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 19111456-1 2009 We developed a simple strategy for designing a highly sensitive electrochemical biosensor for organophosphate pesticides (OPs) based on acetylcholinesterase (AChE) immobilized onto Au nanoparticles-polypyrrole nanowires composite film modifid glassy carbon electrode (labeled as AChE-Au-PPy/GCE). Organophosphates 94-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 19111456-1 2009 We developed a simple strategy for designing a highly sensitive electrochemical biosensor for organophosphate pesticides (OPs) based on acetylcholinesterase (AChE) immobilized onto Au nanoparticles-polypyrrole nanowires composite film modifid glassy carbon electrode (labeled as AChE-Au-PPy/GCE). Organophosphates 94-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 279-283 19111456-1 2009 We developed a simple strategy for designing a highly sensitive electrochemical biosensor for organophosphate pesticides (OPs) based on acetylcholinesterase (AChE) immobilized onto Au nanoparticles-polypyrrole nanowires composite film modifid glassy carbon electrode (labeled as AChE-Au-PPy/GCE). OPS 122-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 19111456-1 2009 We developed a simple strategy for designing a highly sensitive electrochemical biosensor for organophosphate pesticides (OPs) based on acetylcholinesterase (AChE) immobilized onto Au nanoparticles-polypyrrole nanowires composite film modifid glassy carbon electrode (labeled as AChE-Au-PPy/GCE). OPS 122-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 19111456-1 2009 We developed a simple strategy for designing a highly sensitive electrochemical biosensor for organophosphate pesticides (OPs) based on acetylcholinesterase (AChE) immobilized onto Au nanoparticles-polypyrrole nanowires composite film modifid glassy carbon electrode (labeled as AChE-Au-PPy/GCE). OPS 122-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 279-283 19111456-1 2009 We developed a simple strategy for designing a highly sensitive electrochemical biosensor for organophosphate pesticides (OPs) based on acetylcholinesterase (AChE) immobilized onto Au nanoparticles-polypyrrole nanowires composite film modifid glassy carbon electrode (labeled as AChE-Au-PPy/GCE). Gold 181-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 19111456-1 2009 We developed a simple strategy for designing a highly sensitive electrochemical biosensor for organophosphate pesticides (OPs) based on acetylcholinesterase (AChE) immobilized onto Au nanoparticles-polypyrrole nanowires composite film modifid glassy carbon electrode (labeled as AChE-Au-PPy/GCE). Gold 181-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 19111456-1 2009 We developed a simple strategy for designing a highly sensitive electrochemical biosensor for organophosphate pesticides (OPs) based on acetylcholinesterase (AChE) immobilized onto Au nanoparticles-polypyrrole nanowires composite film modifid glassy carbon electrode (labeled as AChE-Au-PPy/GCE). Gold 181-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 279-283 19111456-1 2009 We developed a simple strategy for designing a highly sensitive electrochemical biosensor for organophosphate pesticides (OPs) based on acetylcholinesterase (AChE) immobilized onto Au nanoparticles-polypyrrole nanowires composite film modifid glassy carbon electrode (labeled as AChE-Au-PPy/GCE). polypyrrole 198-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 19111456-1 2009 We developed a simple strategy for designing a highly sensitive electrochemical biosensor for organophosphate pesticides (OPs) based on acetylcholinesterase (AChE) immobilized onto Au nanoparticles-polypyrrole nanowires composite film modifid glassy carbon electrode (labeled as AChE-Au-PPy/GCE). polypyrrole 198-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 19111456-1 2009 We developed a simple strategy for designing a highly sensitive electrochemical biosensor for organophosphate pesticides (OPs) based on acetylcholinesterase (AChE) immobilized onto Au nanoparticles-polypyrrole nanowires composite film modifid glassy carbon electrode (labeled as AChE-Au-PPy/GCE). polypyrrole 198-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 279-283 19111456-1 2009 We developed a simple strategy for designing a highly sensitive electrochemical biosensor for organophosphate pesticides (OPs) based on acetylcholinesterase (AChE) immobilized onto Au nanoparticles-polypyrrole nanowires composite film modifid glassy carbon electrode (labeled as AChE-Au-PPy/GCE). Carbon 250-256 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 19111456-1 2009 We developed a simple strategy for designing a highly sensitive electrochemical biosensor for organophosphate pesticides (OPs) based on acetylcholinesterase (AChE) immobilized onto Au nanoparticles-polypyrrole nanowires composite film modifid glassy carbon electrode (labeled as AChE-Au-PPy/GCE). Carbon 250-256 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 19111456-1 2009 We developed a simple strategy for designing a highly sensitive electrochemical biosensor for organophosphate pesticides (OPs) based on acetylcholinesterase (AChE) immobilized onto Au nanoparticles-polypyrrole nanowires composite film modifid glassy carbon electrode (labeled as AChE-Au-PPy/GCE). Gold 284-286 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 19111456-1 2009 We developed a simple strategy for designing a highly sensitive electrochemical biosensor for organophosphate pesticides (OPs) based on acetylcholinesterase (AChE) immobilized onto Au nanoparticles-polypyrrole nanowires composite film modifid glassy carbon electrode (labeled as AChE-Au-PPy/GCE). Gold 284-286 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 19111456-5 2009 On the basis of the inhibition of OPs on the enzymatic activity of AChE, the conditions for OPs detection were optimized by using methyl parathion as a model OP compound. OPS 34-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 19111456-5 2009 On the basis of the inhibition of OPs on the enzymatic activity of AChE, the conditions for OPs detection were optimized by using methyl parathion as a model OP compound. OPS 92-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 19111456-5 2009 On the basis of the inhibition of OPs on the enzymatic activity of AChE, the conditions for OPs detection were optimized by using methyl parathion as a model OP compound. Methyl Parathion 130-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 19238297-4 2009 The PQQ electrode was then utilized as a thiol-specific sensor for the real-time monitoring of thiocholine generated from the hydrolysis of acetylthiocholine (ASCh) by acetylcholinesterase (AChE). Sulfhydryl Compounds 41-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 190-194 19238297-4 2009 The PQQ electrode was then utilized as a thiol-specific sensor for the real-time monitoring of thiocholine generated from the hydrolysis of acetylthiocholine (ASCh) by acetylcholinesterase (AChE). Thiocholine 95-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-188 19238297-4 2009 The PQQ electrode was then utilized as a thiol-specific sensor for the real-time monitoring of thiocholine generated from the hydrolysis of acetylthiocholine (ASCh) by acetylcholinesterase (AChE). Thiocholine 95-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 190-194 19238297-4 2009 The PQQ electrode was then utilized as a thiol-specific sensor for the real-time monitoring of thiocholine generated from the hydrolysis of acetylthiocholine (ASCh) by acetylcholinesterase (AChE). Acetylthiocholine 140-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-188 19238297-4 2009 The PQQ electrode was then utilized as a thiol-specific sensor for the real-time monitoring of thiocholine generated from the hydrolysis of acetylthiocholine (ASCh) by acetylcholinesterase (AChE). Acetylthiocholine 140-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 190-194 19238297-5 2009 The rapid and sensitive detection of thiocholine allowed monitoring the inhibition of acetylcholinesterase in the presence of the pesticide, carbofuran. Thiocholine 37-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 19238297-5 2009 The rapid and sensitive detection of thiocholine allowed monitoring the inhibition of acetylcholinesterase in the presence of the pesticide, carbofuran. Carbofuran 141-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 19238297-6 2009 These measurements demonstrated the versatility of this sensor for the detection of thiols and potentially for the development of assays to evaluate the enzymatic activity of acetylcholinesterase. Sulfhydryl Compounds 84-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 175-195 19329372-1 2009 We studied bispyridinium oxime K203 [(E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide] with tabun-inhibited human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in vitro, and its antidotal effect on tabun-poisoned mice and rats in vivo. bispyridinium oxime k203 11-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 19329372-1 2009 We studied bispyridinium oxime K203 [(E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide] with tabun-inhibited human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in vitro, and its antidotal effect on tabun-poisoned mice and rats in vivo. bispyridinium oxime k203 11-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-176 19329372-1 2009 We studied bispyridinium oxime K203 [(E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide] with tabun-inhibited human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in vitro, and its antidotal effect on tabun-poisoned mice and rats in vivo. BDBM50333783 37-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 19329372-1 2009 We studied bispyridinium oxime K203 [(E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide] with tabun-inhibited human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in vitro, and its antidotal effect on tabun-poisoned mice and rats in vivo. BDBM50333783 37-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-176 19224517-9 2009 Controlled clinical trials have shown that the acetylcholinesterase inhibitor neostigmine is an effective treatment with initial response rates of 60-90 per cent; other drugs for use in this area are in evolution. Neostigmine 78-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 19101643-1 2009 We assessed the redox thiol status influence on nitric oxide (NO) metabolism and efflux in erythrocytes stimulated with acetylcholinesterase substrate (acetylcholine, ACh) and inhibitor (velnacrine maleate, VM). Sulfhydryl Compounds 22-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 19101643-1 2009 We assessed the redox thiol status influence on nitric oxide (NO) metabolism and efflux in erythrocytes stimulated with acetylcholinesterase substrate (acetylcholine, ACh) and inhibitor (velnacrine maleate, VM). Nitric Oxide 48-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 19101643-7 2009 We concluded that dithiothreitol-induced activation of erythrocyte thiol status decreases NO efflux and allows greater intracellular NO mobilization onto different derivative molecules, both in the absence and presence of acetylcholinesterase substrate and inhibitor. Dithiothreitol 18-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 222-242 19101643-7 2009 We concluded that dithiothreitol-induced activation of erythrocyte thiol status decreases NO efflux and allows greater intracellular NO mobilization onto different derivative molecules, both in the absence and presence of acetylcholinesterase substrate and inhibitor. Sulfhydryl Compounds 67-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 222-242 19319863-0 2009 3-Fluoro-2,4-dioxa-3-phosphadecalins as inhibitors of acetylcholinesterase. 3-fluoro-2,4-dioxa-3-phosphadecalins 0-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 19319863-2 2009 A systematic survey of the acetylcholine-mimetic 2,4-dioxa-3-phosphadecalins as irreversible inhibitors of acetylcholinesterase revealed hitherto overlooked properties as far as the kinetic mechanisms of interaction are concerned. Acetylcholine 27-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 19319863-2 2009 A systematic survey of the acetylcholine-mimetic 2,4-dioxa-3-phosphadecalins as irreversible inhibitors of acetylcholinesterase revealed hitherto overlooked properties as far as the kinetic mechanisms of interaction are concerned. 2,4-dioxa-3-phosphadecalins 49-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 19319864-0 2009 Synthesis and characterization of the enantiomerically pure cis- and trans-2,4-dioxa-3-fluoro-3-phosphadecalins as inhibitors of acetylcholinesterase. -2,4-dioxa-3-fluoro-3-phosphadecalins 74-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-149 18396353-0 2009 Synthesis and evaluation of novel bis-pyridinium oximes as reactivators of DFP-inhibited acetylcholinesterase. bis-pyridinium oximes 34-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 18396353-1 2009 A series of novel bis-pyridinium oximes connected by bis-methoxymethyl benzene, 1,4-bis-methoxymethyl (cis)-but-2-ene and 1,4-bis-methoxymethyl but-2-yne linkers were synthesized and their in vitro reactivation efficacy was evaluated against diisopropyl phosphorofluoridate (DFP) inhibited acetylcholinesterase (AChE) and compared with the established antidote 2-PAM and obidoxime. bis-pyridinium oximes 18-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 290-310 18396353-1 2009 A series of novel bis-pyridinium oximes connected by bis-methoxymethyl benzene, 1,4-bis-methoxymethyl (cis)-but-2-ene and 1,4-bis-methoxymethyl but-2-yne linkers were synthesized and their in vitro reactivation efficacy was evaluated against diisopropyl phosphorofluoridate (DFP) inhibited acetylcholinesterase (AChE) and compared with the established antidote 2-PAM and obidoxime. bis-pyridinium oximes 18-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 312-316 18937214-1 2009 Carbofuran is a pesticide whose acute toxicity is due to inhibition of acetylcholinesterase. Carbofuran 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 18987553-3 2009 It has been also shown that an acetylcholinesterase inhibitor, the short-acting drug edrophonium administered intravenously caused a greater increase in the esophageal contraction amplitude and duration than bethanechol. Edrophonium 85-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 18987553-3 2009 It has been also shown that an acetylcholinesterase inhibitor, the short-acting drug edrophonium administered intravenously caused a greater increase in the esophageal contraction amplitude and duration than bethanechol. Bethanechol 208-219 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 18987553-5 2009 The use of another acetylcholinesterase inhibitor pyridostygmine with longer duration of action has not been studied. pyridostygmine 50-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 19294450-1 2009 Circulating acetylcholine, substrate of membrane acetylcholinesterase (AChE), is known to enhance the band 3 protein degree of phosphorylation. Acetylcholine 12-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 19294450-1 2009 Circulating acetylcholine, substrate of membrane acetylcholinesterase (AChE), is known to enhance the band 3 protein degree of phosphorylation. Acetylcholine 12-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 19262966-2 2009 To demonstrate this approach we examined the cognitive effects of a single acute dose administration of an acetylcholinesterase inhibitor, donepezil, in healthy older adults and in older adults with mild Alzheimer"s disease (AD). Donepezil 139-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 19240946-1 2009 Alkaloids from the plants of Amaryllidaceae family consists of an unique class of nitrogen-containing compounds showing diverse and significant biological activities, including anticancer and acetylcholinesterase (AChE) inhibitory activities. Alkaloids 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-212 19240946-1 2009 Alkaloids from the plants of Amaryllidaceae family consists of an unique class of nitrogen-containing compounds showing diverse and significant biological activities, including anticancer and acetylcholinesterase (AChE) inhibitory activities. Alkaloids 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-218 19240946-1 2009 Alkaloids from the plants of Amaryllidaceae family consists of an unique class of nitrogen-containing compounds showing diverse and significant biological activities, including anticancer and acetylcholinesterase (AChE) inhibitory activities. Nitrogen 82-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-212 19240946-1 2009 Alkaloids from the plants of Amaryllidaceae family consists of an unique class of nitrogen-containing compounds showing diverse and significant biological activities, including anticancer and acetylcholinesterase (AChE) inhibitory activities. Nitrogen 82-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-218 19150463-5 2009 This implies that the main beneficial effect of oximes may result from reactivation of AChE activity in respiratory muscles rather than in the brain. Oximes 48-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 19122189-0 2009 Salivary acetylcholinesterase as a biomarker for organophosphate exposure. Organophosphates 49-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 19101888-0 2009 Acetylcholinesterase activity of alkaloids from the leaves of Waltheria brachypetala. Alkaloids 33-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 19101888-2 2009 The inhibition of activity of acetylcholinesterase (AChE) by the alkaloids was evaluated. Alkaloids 65-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 19150463-7 2009 Albeit the concentration of oximes in the central nervous system is significantly lower than in the plasma, they do gain access into the brain and are able to reactivate inhibited local AChE. Oximes 28-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 19150463-9 2009 In this review, we focus on the ability of oximes to act in the brain and protect the central nervous system from OP-induced injury, either by direct reactivation of AChE or by other pharmacological mechanisms. Oximes 43-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 19154124-1 2009 We report herein a new colorimetric assay method for acetylcholinesterase (AChE) activity and its inhibitor screening by making use of the following facts: (1) the aggregation of gold nanoparticles (Au-NPs) results in the red-shift of the plasmon absorption due to interparticle plasmon interactions and (2) AChE can catalyze the hydrolysis of acetylthiocholine into thiocholine which can induce the aggregation of Au-NPs. Acetylthiocholine 344-361 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 19101888-2 2009 The inhibition of activity of acetylcholinesterase (AChE) by the alkaloids was evaluated. Alkaloids 65-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 19154124-1 2009 We report herein a new colorimetric assay method for acetylcholinesterase (AChE) activity and its inhibitor screening by making use of the following facts: (1) the aggregation of gold nanoparticles (Au-NPs) results in the red-shift of the plasmon absorption due to interparticle plasmon interactions and (2) AChE can catalyze the hydrolysis of acetylthiocholine into thiocholine which can induce the aggregation of Au-NPs. Acetylthiocholine 344-361 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 19154124-1 2009 We report herein a new colorimetric assay method for acetylcholinesterase (AChE) activity and its inhibitor screening by making use of the following facts: (1) the aggregation of gold nanoparticles (Au-NPs) results in the red-shift of the plasmon absorption due to interparticle plasmon interactions and (2) AChE can catalyze the hydrolysis of acetylthiocholine into thiocholine which can induce the aggregation of Au-NPs. Thiocholine 350-361 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 19154124-1 2009 We report herein a new colorimetric assay method for acetylcholinesterase (AChE) activity and its inhibitor screening by making use of the following facts: (1) the aggregation of gold nanoparticles (Au-NPs) results in the red-shift of the plasmon absorption due to interparticle plasmon interactions and (2) AChE can catalyze the hydrolysis of acetylthiocholine into thiocholine which can induce the aggregation of Au-NPs. Thiocholine 350-361 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 19103181-1 2009 Galantamine is an acetylcholinesterase inhibitor and memantine is a non competitive antagonist of NMDA receptors that are being used to treat Alzheimer"s disease (AD) patients. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 19007306-1 2009 Acetylcholinesterase (AChE) plays a central role in the development of Alzheimer"s disease: AChE inhibition for preventing the characteristic dwindling of acetylcholine levels constitutes the current standard treatment for the disorder. Acetylcholine 155-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 19199870-7 2009 Rivastigmine was associated with decreased AChE activity by 42.6% and decreased AChE protein levels by 9.3%, and decreased BuChE activity by 45.6% and decreased BuChE protein levels by 21.8%. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 19199870-7 2009 Rivastigmine was associated with decreased AChE activity by 42.6% and decreased AChE protein levels by 9.3%, and decreased BuChE activity by 45.6% and decreased BuChE protein levels by 21.8%. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 19199870-8 2009 Galantamine decreased AChE activity by 2.1% and BuChE activity by 0.5%, but increased AChE protein levels by 51.2% and BuChE protein levels by 10.5%. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 19199870-8 2009 Galantamine decreased AChE activity by 2.1% and BuChE activity by 0.5%, but increased AChE protein levels by 51.2% and BuChE protein levels by 10.5%. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 19199870-9 2009 Donepezil increased AChE and BuChE activities by 11.8% and 2.8%, respectively. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 19199870-10 2009 Donepezil caused a 215.2% increase in AChE and 0.4% increase in BuChE protein levels. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 19199870-11 2009 Changes in mean AChE-Readthrough/Synaptic ratios, which might reflect underlying neurodegenerative processes, were 1.4, 0.6, and 0.4 for rivastigmine, donepezil and galantamine, respectively. Rivastigmine 137-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 19199870-11 2009 Changes in mean AChE-Readthrough/Synaptic ratios, which might reflect underlying neurodegenerative processes, were 1.4, 0.6, and 0.4 for rivastigmine, donepezil and galantamine, respectively. Donepezil 151-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 19199870-11 2009 Changes in mean AChE-Readthrough/Synaptic ratios, which might reflect underlying neurodegenerative processes, were 1.4, 0.6, and 0.4 for rivastigmine, donepezil and galantamine, respectively. Galantamine 165-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 19199870-13 2009 Rivastigmine provides sustained inhibition of AChE and BuChE, while donepezil and galantamine do not inhibit BuChE and are associated with increases in CSF AChE protein levels. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 19170055-1 2009 A simple and sensitive MEKC with UV detection was developed and validated for the simultaneous determination of acetylcholinesterase inhibitors including galantamine, rivastigmine and major metabolite NAP 226-90 in plasma. Galantamine 154-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 18550228-2 2009 All of the new compounds prepared showed high AChE inhibitory activities, with compound 3e that has an N-hexyl-benzyl piperidine substituent on the nitrogen atom reaching the best inhibitory activity for AChE (IC(50)=5.62 nM). n-hexyl-benzyl piperidine 103-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-208 18550228-2 2009 All of the new compounds prepared showed high AChE inhibitory activities, with compound 3e that has an N-hexyl-benzyl piperidine substituent on the nitrogen atom reaching the best inhibitory activity for AChE (IC(50)=5.62 nM). Nitrogen 148-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-208 19130375-2 2009 This paper reports the construction of the gold/mercaptobenzothiazole/polyaniline/acetylcholinesterase/polyvinylacetate (Au/ MBT/PANI/AChE/PVAc) thick-film biosensor for the determination of certain organophosphate pesticide solutions in selected aqueous organic solvent solutions. polyvinyl acetate 139-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 19130375-3 2009 The Au/MBT/PANI/AChE/PVAc electrocatalytic biosensor device was constructed by encapsulating acetylcholinesterase (AChE) enzyme in the PANI polymer composite, followed by the coating of poly(vinyl acetate) (PVAc) on top to secure the biosensor film from disintegration in the organic solvents evaluated. polyvinyl acetate 21-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 19130375-3 2009 The Au/MBT/PANI/AChE/PVAc electrocatalytic biosensor device was constructed by encapsulating acetylcholinesterase (AChE) enzyme in the PANI polymer composite, followed by the coating of poly(vinyl acetate) (PVAc) on top to secure the biosensor film from disintegration in the organic solvents evaluated. polyvinyl acetate 21-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 19130375-3 2009 The Au/MBT/PANI/AChE/PVAc electrocatalytic biosensor device was constructed by encapsulating acetylcholinesterase (AChE) enzyme in the PANI polymer composite, followed by the coating of poly(vinyl acetate) (PVAc) on top to secure the biosensor film from disintegration in the organic solvents evaluated. pani polymer 135-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 19130375-3 2009 The Au/MBT/PANI/AChE/PVAc electrocatalytic biosensor device was constructed by encapsulating acetylcholinesterase (AChE) enzyme in the PANI polymer composite, followed by the coating of poly(vinyl acetate) (PVAc) on top to secure the biosensor film from disintegration in the organic solvents evaluated. polyvinyl acetate 186-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 19130375-3 2009 The Au/MBT/PANI/AChE/PVAc electrocatalytic biosensor device was constructed by encapsulating acetylcholinesterase (AChE) enzyme in the PANI polymer composite, followed by the coating of poly(vinyl acetate) (PVAc) on top to secure the biosensor film from disintegration in the organic solvents evaluated. polyvinyl acetate 207-211 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 19130375-5 2009 The voltammetric results have shown that the current shifts more anodically as the Au/MBT/PANI/AChE/PVAc biosensor responded to successive acetylthiocholine (ATCh) substrate addition under anaerobic conditions in 0.1 M phosphate buffer, KCl (pH 7.2) solution and aqueous organic solvent solutions. polyvinyl acetate 100-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 19130375-5 2009 The voltammetric results have shown that the current shifts more anodically as the Au/MBT/PANI/AChE/PVAc biosensor responded to successive acetylthiocholine (ATCh) substrate addition under anaerobic conditions in 0.1 M phosphate buffer, KCl (pH 7.2) solution and aqueous organic solvent solutions. Acetylthiocholine 139-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 19130375-5 2009 The voltammetric results have shown that the current shifts more anodically as the Au/MBT/PANI/AChE/PVAc biosensor responded to successive acetylthiocholine (ATCh) substrate addition under anaerobic conditions in 0.1 M phosphate buffer, KCl (pH 7.2) solution and aqueous organic solvent solutions. Acetylthiocholine 158-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 19130375-5 2009 The voltammetric results have shown that the current shifts more anodically as the Au/MBT/PANI/AChE/PVAc biosensor responded to successive acetylthiocholine (ATCh) substrate addition under anaerobic conditions in 0.1 M phosphate buffer, KCl (pH 7.2) solution and aqueous organic solvent solutions. Phosphates 219-228 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 19130375-5 2009 The voltammetric results have shown that the current shifts more anodically as the Au/MBT/PANI/AChE/PVAc biosensor responded to successive acetylthiocholine (ATCh) substrate addition under anaerobic conditions in 0.1 M phosphate buffer, KCl (pH 7.2) solution and aqueous organic solvent solutions. Potassium Chloride 237-240 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 18729824-0 2009 Accommodation of physostigmine and its analogues by acetylcholinesterase is dominated by hydrophobic interactions. Physostigmine 17-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 18729824-1 2009 The role of the functional architecture of the HuAChE (human acetylcholinesterase) in reactivity toward the carbamates pyridostigmine, rivastigmine and several analogues of physostigmine, that are currently used or considered for use as drugs for Alzheimer"s disease, was analysed using over 20 mutants of residues that constitute the interaction subsites in the active centre. Carbamates 108-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 18729824-1 2009 The role of the functional architecture of the HuAChE (human acetylcholinesterase) in reactivity toward the carbamates pyridostigmine, rivastigmine and several analogues of physostigmine, that are currently used or considered for use as drugs for Alzheimer"s disease, was analysed using over 20 mutants of residues that constitute the interaction subsites in the active centre. Pyridostigmine Bromide 119-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 18729824-1 2009 The role of the functional architecture of the HuAChE (human acetylcholinesterase) in reactivity toward the carbamates pyridostigmine, rivastigmine and several analogues of physostigmine, that are currently used or considered for use as drugs for Alzheimer"s disease, was analysed using over 20 mutants of residues that constitute the interaction subsites in the active centre. Rivastigmine 135-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 18729824-1 2009 The role of the functional architecture of the HuAChE (human acetylcholinesterase) in reactivity toward the carbamates pyridostigmine, rivastigmine and several analogues of physostigmine, that are currently used or considered for use as drugs for Alzheimer"s disease, was analysed using over 20 mutants of residues that constitute the interaction subsites in the active centre. Physostigmine 173-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 19007306-1 2009 Acetylcholinesterase (AChE) plays a central role in the development of Alzheimer"s disease: AChE inhibition for preventing the characteristic dwindling of acetylcholine levels constitutes the current standard treatment for the disorder. Acetylcholine 155-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 19007306-1 2009 Acetylcholinesterase (AChE) plays a central role in the development of Alzheimer"s disease: AChE inhibition for preventing the characteristic dwindling of acetylcholine levels constitutes the current standard treatment for the disorder. Acetylcholine 155-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 19007306-2 2009 Amongst the diverse risk factors contributing to the degenerative process, high cholesterol causes a reduction in the effectiveness of the otherwise therapeutic inhibitors of AChE. Cholesterol 80-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 175-179 19007306-5 2009 Additional experiments using AChE inhibitors (amphiphilic procaine hydrochloride, hydrophobic tetrabutylammonium bromide) in the absence or presence of detergent further illustrate the detergent-enzyme-solvent interactions. Procaine 58-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 19007306-5 2009 Additional experiments using AChE inhibitors (amphiphilic procaine hydrochloride, hydrophobic tetrabutylammonium bromide) in the absence or presence of detergent further illustrate the detergent-enzyme-solvent interactions. tetrabutylammonium 94-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 19007306-8 2009 This model may also be used to assess and predict the effectiveness of AChE inhibitors, which are traditionally used for the treatment of cognitive impairment, under pathological (high-cholesterol) conditions. Cholesterol 185-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 19526145-1 2009 Fluorescence intensity of thioflavin T fluorogenic label increased significantly as a result of formation of enzyme-inhibitory complex with acetylcholinesterase of human blood erythrocytes. thioflavin T 26-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-160 19526145-2 2009 Thioflavin T is a reversible inhibitor, selectively reacting with acetylcholinesterase. thioflavin T 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 19526145-3 2009 Thioflavin T fluorescence intensity is proportional to acetylcholinesterase activity for the studied interval of enzyme activities. thioflavin T 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 19519385-3 2009 Their mechanism of action is reactivation of acetylcholinesterase (AChE) inhibited by organophosphorus agents. organophosphorus 86-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 19199985-3 2009 Our first rationally designed MTDL was the polyamine caproctamine (1), which provided a synergistic cholinergic action against AD by antagonizing muscarinic M(2) autoreceptors and inhibiting acetylcholinesterase (AChE). Polyamines 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 191-211 19199985-3 2009 Our first rationally designed MTDL was the polyamine caproctamine (1), which provided a synergistic cholinergic action against AD by antagonizing muscarinic M(2) autoreceptors and inhibiting acetylcholinesterase (AChE). Polyamines 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-217 19199985-3 2009 Our first rationally designed MTDL was the polyamine caproctamine (1), which provided a synergistic cholinergic action against AD by antagonizing muscarinic M(2) autoreceptors and inhibiting acetylcholinesterase (AChE). caproctamine 53-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 191-211 19199985-3 2009 Our first rationally designed MTDL was the polyamine caproctamine (1), which provided a synergistic cholinergic action against AD by antagonizing muscarinic M(2) autoreceptors and inhibiting acetylcholinesterase (AChE). caproctamine 53-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-217 19519385-3 2009 Their mechanism of action is reactivation of acetylcholinesterase (AChE) inhibited by organophosphorus agents. organophosphorus 86-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 19519385-6 2009 The mechanism of OPC poisoning involves phosphorylation of the serine hydroxyl group at the active site of AChE leading to the inactivation of this essential enzyme, which has an important role in neurotransmission. serine hydroxyl 63-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 19519385-7 2009 AChE inhibition results in the accumulation of acetylcholine at cholinergic receptor sites, producing continuous stimulation of cholinergic fibers throughout the central and peripheral nervous systems. Acetylcholine 47-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 19519385-8 2009 Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the standard pyridinium oximes (pralidoxime, trimedoxime, obidoxime, HI-6) and diazepam has been used for the treatment of organophosphate poisoning in humans. pyridinium oximes 113-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 19519385-8 2009 Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the standard pyridinium oximes (pralidoxime, trimedoxime, obidoxime, HI-6) and diazepam has been used for the treatment of organophosphate poisoning in humans. Obidoxime Chloride 158-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 19689278-1 2009 Prophylactic approaches against intoxication with organophosphates (OP)/nerve agents can be based on following principles: keeping acetylcholinesterase (AChE), the key enzyme for toxic action of OP/nerve agents, intact (protection of cholinesterases) is a basic requirement for effective prophylaxis. Organophosphates 50-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-151 19689278-1 2009 Prophylactic approaches against intoxication with organophosphates (OP)/nerve agents can be based on following principles: keeping acetylcholinesterase (AChE), the key enzyme for toxic action of OP/nerve agents, intact (protection of cholinesterases) is a basic requirement for effective prophylaxis. Organophosphates 50-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 19519385-8 2009 Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the standard pyridinium oximes (pralidoxime, trimedoxime, obidoxime, HI-6) and diazepam has been used for the treatment of organophosphate poisoning in humans. asoxime chloride 169-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 19689278-2 2009 It can be reached using simple chemicals such as reversible inhibitors (preferably carbamates), which are able to inhibit AChE reversibly. Carbamates 83-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 19689278-3 2009 AChE inhibited by carbamates is resistant to OP/nerve agent inhibition. Carbamates 18-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 19519385-8 2009 Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the standard pyridinium oximes (pralidoxime, trimedoxime, obidoxime, HI-6) and diazepam has been used for the treatment of organophosphate poisoning in humans. Diazepam 179-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 19519385-8 2009 Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the standard pyridinium oximes (pralidoxime, trimedoxime, obidoxime, HI-6) and diazepam has been used for the treatment of organophosphate poisoning in humans. Organophosphates 223-238 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 19356117-0 2009 Study of efficacy of reactivator HI 6 in reactivation of immobilized acetylcholinesterase, inhibited by organophosphorus chemical warfare agents of the "G" series. asoxime chloride 33-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 19356117-0 2009 Study of efficacy of reactivator HI 6 in reactivation of immobilized acetylcholinesterase, inhibited by organophosphorus chemical warfare agents of the "G" series. organophosphorus 104-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 21383875-5 2009 When surface AChE was tagged with FITC-conjugated Fasciculin II (FasII), fluorescence gradually accumulated in intracellular particles. Fluorescein-5-isothiocyanate 34-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 19145051-2 2009 Organophosphate compounds cause poisoning, inhibiting acetylcholinesterase at the cholinergic synapses. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 19494441-1 2009 Although clinical and experimental research has demonstrated that acetylcholinesterase inhibitors, such as donepezil, are able to enhance cognitive functioning in intact subjects as well as in patients affected by different degrees of dementia, no morphological study has ever analyzed whether donepezil treatment is able to modify neocortical neuronal morphology in the intact brain and in response to cholinergic depletion. Donepezil 107-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 19363262-1 2009 Donepezil, an acetylcholinesterase (AChE) inhibitor used for treating Alzheimer"s disease patients, is thought to act by increasing brain extracellular acetylcholine (ACh), and ACh binding to cholinergic receptors. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 19363262-1 2009 Donepezil, an acetylcholinesterase (AChE) inhibitor used for treating Alzheimer"s disease patients, is thought to act by increasing brain extracellular acetylcholine (ACh), and ACh binding to cholinergic receptors. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 19363262-1 2009 Donepezil, an acetylcholinesterase (AChE) inhibitor used for treating Alzheimer"s disease patients, is thought to act by increasing brain extracellular acetylcholine (ACh), and ACh binding to cholinergic receptors. Acetylcholine 14-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 19363262-1 2009 Donepezil, an acetylcholinesterase (AChE) inhibitor used for treating Alzheimer"s disease patients, is thought to act by increasing brain extracellular acetylcholine (ACh), and ACh binding to cholinergic receptors. Acetylcholine 36-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 19363262-1 2009 Donepezil, an acetylcholinesterase (AChE) inhibitor used for treating Alzheimer"s disease patients, is thought to act by increasing brain extracellular acetylcholine (ACh), and ACh binding to cholinergic receptors. Acetylcholine 167-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 19363262-1 2009 Donepezil, an acetylcholinesterase (AChE) inhibitor used for treating Alzheimer"s disease patients, is thought to act by increasing brain extracellular acetylcholine (ACh), and ACh binding to cholinergic receptors. Acetylcholine 167-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 19159094-6 2009 In particular, a method based on the inhibition of the enzyme acetylcholinesterase (AChE) for the detection of organophosphorus and carbamate pesticides will be described in detail. organophosphorus 111-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 19159094-6 2009 In particular, a method based on the inhibition of the enzyme acetylcholinesterase (AChE) for the detection of organophosphorus and carbamate pesticides will be described in detail. organophosphorus 111-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 19159094-6 2009 In particular, a method based on the inhibition of the enzyme acetylcholinesterase (AChE) for the detection of organophosphorus and carbamate pesticides will be described in detail. Carbamates 132-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 19159094-6 2009 In particular, a method based on the inhibition of the enzyme acetylcholinesterase (AChE) for the detection of organophosphorus and carbamate pesticides will be described in detail. Carbamates 132-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 19194505-1 2009 Aphids, among the most destructive insects to world agriculture, are mainly controlled by organophosphate insecticides that disable the catalytic serine residue of acetylcholinesterase (AChE). Organophosphates 90-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-184 19194505-1 2009 Aphids, among the most destructive insects to world agriculture, are mainly controlled by organophosphate insecticides that disable the catalytic serine residue of acetylcholinesterase (AChE). Organophosphates 90-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 19194505-1 2009 Aphids, among the most destructive insects to world agriculture, are mainly controlled by organophosphate insecticides that disable the catalytic serine residue of acetylcholinesterase (AChE). Serine 146-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-184 19194505-1 2009 Aphids, among the most destructive insects to world agriculture, are mainly controlled by organophosphate insecticides that disable the catalytic serine residue of acetylcholinesterase (AChE). Serine 146-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 19194505-3 2009 We previously reported that a cysteine residue (Cys), found at the AChE active site in aphids and other insects but not mammals, might serve as a target for insect-selective pesticides. Cysteine 30-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 19194505-3 2009 We previously reported that a cysteine residue (Cys), found at the AChE active site in aphids and other insects but not mammals, might serve as a target for insect-selective pesticides. Cysteine 48-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 19194505-5 2009 The absence of the active-site Cys in AO-AChE might raise concerns about the utility of targeting that residue. Cysteine 31-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 19194505-6 2009 Herein we report the development of a methanethiosulfonate-containing small molecule that, at 6.0 microM, irreversibly inhibits 99% of all AChE activity extracted from the greenbug aphid (Schizaphis graminum) without any measurable inhibition of the human AChE. methanethiosulfonate 38-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 19194505-6 2009 Herein we report the development of a methanethiosulfonate-containing small molecule that, at 6.0 microM, irreversibly inhibits 99% of all AChE activity extracted from the greenbug aphid (Schizaphis graminum) without any measurable inhibition of the human AChE. methanethiosulfonate 38-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 256-260 19194505-9 2009 More importantly, by demonstrating that the Cys-targeting inhibitor can abolish AChE activity in aphids, we can conclude that the unique Cys may be a viable target for species-selective agents to control aphids without causing human toxicity and resistance problems. Cysteine 44-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 19194505-9 2009 More importantly, by demonstrating that the Cys-targeting inhibitor can abolish AChE activity in aphids, we can conclude that the unique Cys may be a viable target for species-selective agents to control aphids without causing human toxicity and resistance problems. Cysteine 137-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 19149713-4 2009 Therefore, the most important therapeutic approach has emerged as inhibition of acetylcholinesterase (AChE), which is the key enzyme in the breakdown of acetylcholine. Acetylcholine 80-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 18651722-6 2009 MEA-induced bronchoconstriction was not enhanced by premedication with an intravenous injection of neostigmine (0.1 mg kg(-1)), an acetylcholinesterase inhibitor. Ethanolamine 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-151 19921590-0 2009 Synthesis, phytotoxic, cytotoxic, acetylcholinesterase and butrylcholinesterase activities of N,N"-diaryl unsymmetrically substituted thioureas. n,n"-diaryl 94-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 19921590-0 2009 Synthesis, phytotoxic, cytotoxic, acetylcholinesterase and butrylcholinesterase activities of N,N"-diaryl unsymmetrically substituted thioureas. Thiourea 134-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 19921590-1 2009 Fourteen N,N"-diaryl unsymmetrically substituted thioureas were synthesised and their cytotoxic (in vitro), phytotoxic (in vitro), acetylcholinesterase and butrylcholinesterase activities were determined. Thiourea 49-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-151 19110209-6 2009 Over the past decade, our group has developed several series of dimeric acetylcholinesterase (AChE) inhibitors derived from tacrine and huperzine A, a unique anti-Alzheimer"s drug originally discovered from a traditional Chinese medicinal plant. Tacrine 124-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 19110209-6 2009 Over the past decade, our group has developed several series of dimeric acetylcholinesterase (AChE) inhibitors derived from tacrine and huperzine A, a unique anti-Alzheimer"s drug originally discovered from a traditional Chinese medicinal plant. huperzine A 136-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 19110209-7 2009 Bis(7)-Cognitin, one of our novel dimers, through inhibition of AChE, N-methyl-D-aspartate receptor, nitric oxide synthase, and amyloid precursor protein/beta-amyloid cascade concurrently, possesses remarkable neuroprotective activities. 1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydroacridine 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 22408512-0 2009 Nanomaterials - acetylcholinesterase enzyme matrices for organophosphorus pesticides electrochemical sensors: a review. organophosphorus 57-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 22408512-3 2009 This catalytic activity of AChE is drastically inhibited by trace amounts of organophosphorus (OP) pesticides present in the environment. organophosphorus 77-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 22408512-5 2009 In such sensors, the enzyme AChE has been immobilized onto nanomaterials like multiwalled carbon nanotubes, gold nanoparticles, zirconia nanoparticles, cadmium sulphide nano particles or quantum dots. Carbon 90-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 22408512-5 2009 In such sensors, the enzyme AChE has been immobilized onto nanomaterials like multiwalled carbon nanotubes, gold nanoparticles, zirconia nanoparticles, cadmium sulphide nano particles or quantum dots. zirconium oxide 128-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 22408512-5 2009 In such sensors, the enzyme AChE has been immobilized onto nanomaterials like multiwalled carbon nanotubes, gold nanoparticles, zirconia nanoparticles, cadmium sulphide nano particles or quantum dots. cadmium sulfide 152-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 19006330-0 2008 Analysis of the reaction of carbachol with acetylcholinesterase using thioflavin T as a coupled fluorescence reporter. Carbachol 28-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 19006330-0 2008 Analysis of the reaction of carbachol with acetylcholinesterase using thioflavin T as a coupled fluorescence reporter. thioflavin T 70-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 19006330-3 2008 Carbamates are very poor substrates that, like other AChE substrates, form an initial enzyme-substrate complex with free AChE (E) and proceed to an acylated enzyme intermediate (EC), which is then hydrolyzed. Carbamates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 19006330-3 2008 Carbamates are very poor substrates that, like other AChE substrates, form an initial enzyme-substrate complex with free AChE (E) and proceed to an acylated enzyme intermediate (EC), which is then hydrolyzed. Carbamates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 19006330-5 2008 Here, we focus on the reaction of carbachol (carbamoylcholine) with AChE. Carbachol 34-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 19006330-5 2008 Here, we focus on the reaction of carbachol (carbamoylcholine) with AChE. Carbachol 45-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 19006330-8 2008 The fluorescence of thioflavin T is strongly enhanced when it binds to the P-site of AChE, and this fluorescence is partially quenched when a second ligand binds to the A-site to form a ternary complex. thioflavin T 20-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 19094390-6 2008 Enzymatic hydrolysis of ACh by AChE was directly monitored as it took place in the flow-through sensor. Acetylcholine 24-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 19094390-7 2008 The inhibition effect of tacrine was calculated from the reaction-induced spectral changes, revealing an important decrease in the activity of AChE, approaching zero when the inhibitor concentration is high enough. Tacrine 25-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 19031285-7 2008 Atropine was given to about 30% of the individuals, including to some with no cholinergic symptoms or exposed to non-acetylcholinesterase inhibitors. Atropine 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 18789720-4 2008 For Huperzine A, the linear mixed inhibition of AChE reflected the presence of competitive and noncompetitive components. huperzine A 4-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 18615283-0 2008 Photometric microplate assay for estimation of the efficacy of paraoxon-inhibited acetylcholinesterase reactivation. Paraoxon 63-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 18615283-1 2008 Photometric microplate assay was performed for testing of paraoxon-inhibited acetylcholinesterase (AChE) using three reactivators for reactivation purposes: obidoxime, pralidoxime, and HI-6. Paraoxon 58-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 18615283-1 2008 Photometric microplate assay was performed for testing of paraoxon-inhibited acetylcholinesterase (AChE) using three reactivators for reactivation purposes: obidoxime, pralidoxime, and HI-6. Paraoxon 58-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 18789720-5 2008 The half maximal inhibitory concentration (IC(50)) value of galantamine obtained for AChE was 2.39 micromol L(-1). Galantamine 60-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 18844288-8 2008 Spasm of the gut induced by the acetylcholinesterase inhibitor, physostigmine, was antagonized by ascorbigen with an IC50 of 286 microM. Physostigmine 64-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 18844288-8 2008 Spasm of the gut induced by the acetylcholinesterase inhibitor, physostigmine, was antagonized by ascorbigen with an IC50 of 286 microM. ascorbigen 98-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 18975951-2 2008 Organophosphates (OPs) exert their acute toxicity through inhibition of acetylcholinesterase (AChE) by phosphorylation of the catalytic serine. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 18975951-2 2008 Organophosphates (OPs) exert their acute toxicity through inhibition of acetylcholinesterase (AChE) by phosphorylation of the catalytic serine. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 18975951-2 2008 Organophosphates (OPs) exert their acute toxicity through inhibition of acetylcholinesterase (AChE) by phosphorylation of the catalytic serine. Organophosphates 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 18975951-2 2008 Organophosphates (OPs) exert their acute toxicity through inhibition of acetylcholinesterase (AChE) by phosphorylation of the catalytic serine. Organophosphates 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 18975951-2 2008 Organophosphates (OPs) exert their acute toxicity through inhibition of acetylcholinesterase (AChE) by phosphorylation of the catalytic serine. Serine 136-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 18975951-2 2008 Organophosphates (OPs) exert their acute toxicity through inhibition of acetylcholinesterase (AChE) by phosphorylation of the catalytic serine. Serine 136-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 18855408-1 2008 A new magnetic electrochemical immunoassay has been developed as a tool for biomonitoring exposures to organophosphate (OP) compounds, e.g., insecticides and chemical nerve agents, by directly detecting organophosphorylated acetylcholinesterase (OP-AChE). Organophosphates 103-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 224-244 18855408-1 2008 A new magnetic electrochemical immunoassay has been developed as a tool for biomonitoring exposures to organophosphate (OP) compounds, e.g., insecticides and chemical nerve agents, by directly detecting organophosphorylated acetylcholinesterase (OP-AChE). Organophosphates 103-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 249-253 18855408-3 2008 A pair of antibodies was used to achieve the specific recognition of OP-AChE that was prepared with paraoxon as an OP model agent. Paraoxon 100-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 18855408-4 2008 Antiphosphoserine polyclonal antibodies were anchored on amorphous magnetic particles preferably chosen to capture OP-AChE from the sample matrixes by binding their phosphoserine moieties that were exposed through unfolding the protein adducts. Phosphoserine 4-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 18855408-6 2008 Furthermore, antihuman AChE monoclonal antibodies were labeled with cadmium-source QDs to selectively recognize the captured OP-AChE, as characterized by transmission electron microscopy. Cadmium 68-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 18855408-6 2008 Furthermore, antihuman AChE monoclonal antibodies were labeled with cadmium-source QDs to selectively recognize the captured OP-AChE, as characterized by transmission electron microscopy. Cadmium 68-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 18821801-1 2008 Two diastereomers of a phosphonate analog 6 of the AChE inhibitor cyclophostin were synthesized. Organophosphonates 23-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 18821801-1 2008 Two diastereomers of a phosphonate analog 6 of the AChE inhibitor cyclophostin were synthesized. cyclophostin 66-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 18821801-5 2008 The trans phosphonate isomer was more active than the cis isomer against AChE from two sources. trans phosphonate 4-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 18772221-3 2008 An increase (~30%) in the activity of the acetylcholine-hydrolyzing enzyme, acetylcholinesterase (AChE) is observed in the brain cortex from patients deceased from hepatic coma, while the activity of the acetylcholine-synthesizing enzyme, choline acetyltransferase, remains unaffected. Acetylcholine 42-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 18772221-3 2008 An increase (~30%) in the activity of the acetylcholine-hydrolyzing enzyme, acetylcholinesterase (AChE) is observed in the brain cortex from patients deceased from hepatic coma, while the activity of the acetylcholine-synthesizing enzyme, choline acetyltransferase, remains unaffected. Acetylcholine 42-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 18772221-7 2008 A selective increase of tetrameric AChE, the major AChE species involved in hydrolysis of acetylcholine in the brain, was detected in both cirrhotic humans and BDL rats. Acetylcholine 90-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 18772221-7 2008 A selective increase of tetrameric AChE, the major AChE species involved in hydrolysis of acetylcholine in the brain, was detected in both cirrhotic humans and BDL rats. Acetylcholine 90-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 18675298-1 2008 Acetylcholinesterase (AChE) was immobilized on two different composite membranes constituted by a chemically modified poly-acrylonitrile (PAN) membrane plus a layer of tethered chitosan of different molecular weight, 10 kDa or 400 kDa. polyacrylonitrile 118-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 18675298-1 2008 Acetylcholinesterase (AChE) was immobilized on two different composite membranes constituted by a chemically modified poly-acrylonitrile (PAN) membrane plus a layer of tethered chitosan of different molecular weight, 10 kDa or 400 kDa. polyacrylonitrile 118-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 18675298-2 2008 AChE was also directly immobilized on a chemically modified PAN membrane with NaOH and ethylenediamine (EDA) without chitosan. Sodium Hydroxide 78-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 18675298-2 2008 AChE was also directly immobilized on a chemically modified PAN membrane with NaOH and ethylenediamine (EDA) without chitosan. ethylenediamine 87-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 18675298-2 2008 AChE was also directly immobilized on a chemically modified PAN membrane with NaOH and ethylenediamine (EDA) without chitosan. ethylenediamine 104-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 18675298-2 2008 AChE was also directly immobilized on a chemically modified PAN membrane with NaOH and ethylenediamine (EDA) without chitosan. Chitosan 117-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 18675298-5 2008 The results concerning the AChE inhibition by methyl-paraoxon and the subsequent reactivation by pyridine-2-aldoxime methochloride (2-PAM) are presented and discussed. methylparaoxon 46-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 18675298-5 2008 The results concerning the AChE inhibition by methyl-paraoxon and the subsequent reactivation by pyridine-2-aldoxime methochloride (2-PAM) are presented and discussed. pralidoxime 97-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 18804623-0 2008 Alumina sol-gel/sonogel-carbon electrode based on acetylcholinesterase for detection of organophosphorus pesticides. Aluminum Oxide 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 18211261-5 2008 The results show that the fluid secreted by human lung cells contains enough AChE (acetylcholinesterase) activity to control ACh levels. Acetylcholine 77-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 18548743-1 2008 In search for more efficacious reactivators of acetylcholinesterase (AChE) inhibited by organophosphorus compounds, experimental K-oximes have been synthesized which show good in vitro efficacy. organophosphorus 88-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 18548743-1 2008 In search for more efficacious reactivators of acetylcholinesterase (AChE) inhibited by organophosphorus compounds, experimental K-oximes have been synthesized which show good in vitro efficacy. organophosphorus 88-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 18548743-1 2008 In search for more efficacious reactivators of acetylcholinesterase (AChE) inhibited by organophosphorus compounds, experimental K-oximes have been synthesized which show good in vitro efficacy. k-oximes 129-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 18548743-1 2008 In search for more efficacious reactivators of acetylcholinesterase (AChE) inhibited by organophosphorus compounds, experimental K-oximes have been synthesized which show good in vitro efficacy. k-oximes 129-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 18548743-2 2008 However, AChE inhibition by oximes themselves (as quantified by their intrinsic IC50) is the major cause of oxime toxicity and the dose-limiting factor. Oximes 28-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 18548743-2 2008 However, AChE inhibition by oximes themselves (as quantified by their intrinsic IC50) is the major cause of oxime toxicity and the dose-limiting factor. Oximes 28-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 18821258-0 2008 Synthesis and biological evaluation of new donepezil-like Thiaindanones as AChE inhibitors. Donepezil 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 18821258-0 2008 Synthesis and biological evaluation of new donepezil-like Thiaindanones as AChE inhibitors. thiaindanones 58-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 18821258-1 2008 Pharmacomodulations of previously reported thiaindanones related to donepezil were achieved with the aim to enhance their AChE inhibitory activity. thiaindanones 43-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 18821258-1 2008 Pharmacomodulations of previously reported thiaindanones related to donepezil were achieved with the aim to enhance their AChE inhibitory activity. Donepezil 68-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 19079407-4 2008 The toxicity of these OP pesticides is due to the irreversible inhibition of acetylcholinesterase (AChE) enzyme leading to accumulation of acetylcholine and subsequent over-activation of cholinergic receptors in various parts of the body. Acetylcholine 77-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 18855728-9 2008 The potency of all newly synthesized oximes to reactivate tabun-inhibited AChE is comparable with obidoxime with the exception of K074 that is significantly more efficacious in the brain. Oximes 37-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 18671198-0 2008 Acylphenols from Myristica crassa as new acetylcholinesterase inhibitors. acylphenols 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 18671198-1 2008 A significant acetylcholinesterase inhibitory activity was observed for the ethyl acetate and methanol extracts from the leaves and the fruits of MYRISTICA CRASSA. ethyl acetate 76-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 18671198-1 2008 A significant acetylcholinesterase inhibitory activity was observed for the ethyl acetate and methanol extracts from the leaves and the fruits of MYRISTICA CRASSA. Methanol 94-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 18452905-6 2008 To understand the dynamical properties of acetylcholinesterase (AChE) in rapid termination of cationic neurotransmitter, acetylcholine at neurosynaptic junctions, multiple molecular dynamics (MD) trajectories of AChE in the presence and absence of its inhibitors [J.M. Acetylcholine 42-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 18452905-6 2008 To understand the dynamical properties of acetylcholinesterase (AChE) in rapid termination of cationic neurotransmitter, acetylcholine at neurosynaptic junctions, multiple molecular dynamics (MD) trajectories of AChE in the presence and absence of its inhibitors [J.M. Acetylcholine 42-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 212-216 18457821-1 2008 The rate and duration of inhibition of recombinant human acetylcholinesterase (AChE) and human butyrylcholinesterase (BuChE) by nine N-methyl,N-alkyl derivatives of (R)-3-prop-2-ynylamino-indan, designed as potential treatment of Alzheimer"s disease, was obtained from measurement of the carbamylation k(i) and decarbamylation k(3) rate constants. n-methyl,n-alkyl 133-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 18457821-1 2008 The rate and duration of inhibition of recombinant human acetylcholinesterase (AChE) and human butyrylcholinesterase (BuChE) by nine N-methyl,N-alkyl derivatives of (R)-3-prop-2-ynylamino-indan, designed as potential treatment of Alzheimer"s disease, was obtained from measurement of the carbamylation k(i) and decarbamylation k(3) rate constants. n-methyl,n-alkyl 133-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 18457821-1 2008 The rate and duration of inhibition of recombinant human acetylcholinesterase (AChE) and human butyrylcholinesterase (BuChE) by nine N-methyl,N-alkyl derivatives of (R)-3-prop-2-ynylamino-indan, designed as potential treatment of Alzheimer"s disease, was obtained from measurement of the carbamylation k(i) and decarbamylation k(3) rate constants. (r)-3-prop-2-ynylamino-indan 165-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 18457821-1 2008 The rate and duration of inhibition of recombinant human acetylcholinesterase (AChE) and human butyrylcholinesterase (BuChE) by nine N-methyl,N-alkyl derivatives of (R)-3-prop-2-ynylamino-indan, designed as potential treatment of Alzheimer"s disease, was obtained from measurement of the carbamylation k(i) and decarbamylation k(3) rate constants. (r)-3-prop-2-ynylamino-indan 165-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 18482720-5 2008 Incubation with PIPLC revealed glycosylphosphatidylinositol in AChE forms. Glycosylphosphatidylinositols 31-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 18501341-0 2008 Oximes: Reactivators of phosphorylated acetylcholinesterase and antidotes in therapy against tabun poisoning. Oximes 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 18501341-0 2008 Oximes: Reactivators of phosphorylated acetylcholinesterase and antidotes in therapy against tabun poisoning. tabun 93-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 18501341-1 2008 One of the therapeutic approaches to organophosphate poisoning is to reactivate AChE with site-directed nucleophiles such as oximes. Organophosphates 37-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 18501341-1 2008 One of the therapeutic approaches to organophosphate poisoning is to reactivate AChE with site-directed nucleophiles such as oximes. Oximes 125-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 18501341-3 2008 We tested oximes varying in the type of ring (pyridinium and/or imidazolium), the length and type of the linker between rings, and in the position of the oxime group on the ring to find more effective oximes to reactivate tabun-inhibited human erythrocyte AChE. Oximes 201-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 256-260 18501341-4 2008 Three of our tested pyridinium oximes K027, K048, K074, along with TMB-4, were the most promising for AChE reactivation. pyridinium oximes 20-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 18501341-4 2008 Three of our tested pyridinium oximes K027, K048, K074, along with TMB-4, were the most promising for AChE reactivation. Trimedoxime 67-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 18501341-7 2008 Since the reactivating efficacy of the oximes in vitro corresponded to their therapeutic efficacy in vivo, it seems that pharmacological effect of these oximes is indeed primarily related to the reactivation of tabun-phosphorylated AChE. Oximes 39-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 232-236 18501341-7 2008 Since the reactivating efficacy of the oximes in vitro corresponded to their therapeutic efficacy in vivo, it seems that pharmacological effect of these oximes is indeed primarily related to the reactivation of tabun-phosphorylated AChE. Oximes 153-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 232-236 18501885-3 2008 Both cholinesterases showed the highest affinity for K114 (K(i) was 0.01 mM for AChE and 0.06 mM for BChE). K114 53-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 18501885-6 2008 The reactivation of tabun-inhibited AChE assisted by K114 was slow and reached 90% after 20 h. Since the aldoxime binding affinity of tabun-inhibited AChE was similar for all tested aldoximes (and corresponded to their K(i)), the rate of the nucleophilic displacement of the phosphoryl-moiety from the active site serine was the limiting factor for AChE reactivation. K114 53-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 18501885-6 2008 The reactivation of tabun-inhibited AChE assisted by K114 was slow and reached 90% after 20 h. Since the aldoxime binding affinity of tabun-inhibited AChE was similar for all tested aldoximes (and corresponded to their K(i)), the rate of the nucleophilic displacement of the phosphoryl-moiety from the active site serine was the limiting factor for AChE reactivation. acetaldehyde oxime 105-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 18501885-6 2008 The reactivation of tabun-inhibited AChE assisted by K114 was slow and reached 90% after 20 h. Since the aldoxime binding affinity of tabun-inhibited AChE was similar for all tested aldoximes (and corresponded to their K(i)), the rate of the nucleophilic displacement of the phosphoryl-moiety from the active site serine was the limiting factor for AChE reactivation. acetaldehyde oxime 105-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 18501885-6 2008 The reactivation of tabun-inhibited AChE assisted by K114 was slow and reached 90% after 20 h. Since the aldoxime binding affinity of tabun-inhibited AChE was similar for all tested aldoximes (and corresponded to their K(i)), the rate of the nucleophilic displacement of the phosphoryl-moiety from the active site serine was the limiting factor for AChE reactivation. acetaldehyde oxime 105-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 18501885-6 2008 The reactivation of tabun-inhibited AChE assisted by K114 was slow and reached 90% after 20 h. Since the aldoxime binding affinity of tabun-inhibited AChE was similar for all tested aldoximes (and corresponded to their K(i)), the rate of the nucleophilic displacement of the phosphoryl-moiety from the active site serine was the limiting factor for AChE reactivation. Serine 314-320 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 18508040-17 2008 According to the putative water-activation mechanism of G117H BChE, a new histidine/aspartate dyad was introduced into the active center of human AChE at the optimum location for hydrolysis of the OP adduct. Water 26-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 18508040-17 2008 According to the putative water-activation mechanism of G117H BChE, a new histidine/aspartate dyad was introduced into the active center of human AChE at the optimum location for hydrolysis of the OP adduct. Histidine 74-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 18508040-17 2008 According to the putative water-activation mechanism of G117H BChE, a new histidine/aspartate dyad was introduced into the active center of human AChE at the optimum location for hydrolysis of the OP adduct. Aspartic Acid 84-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 18514177-4 2008 The AChE(H) variant produces a GPI-anchored dimer that is mainly expressed in blood cells, while AChE(T) variant is largely predominant in the brain and muscle. Glycosylphosphatidylinositols 31-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 18514177-5 2008 AChE(T) subunits associate with a collagen tail subunit (ColQ) forming asymmetric AChE species (A(4), A(8), and A(12) AChE) in muscle, and also form amphiphilic tetramers associated with a proline-rich membrane anchor (PRiMA) as globular AChE (G(4) AChE) in brain and muscle. Proline 189-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 18538755-1 2008 The classical function of acetylcholinesterase (AChE) is to terminate synaptic transmission at cholinergic synapses by rapidly hydrolyzing the neurotransmitter acetylcholine (ACh). Acetylcholine 26-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 18538755-1 2008 The classical function of acetylcholinesterase (AChE) is to terminate synaptic transmission at cholinergic synapses by rapidly hydrolyzing the neurotransmitter acetylcholine (ACh). Acetylcholine 48-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 18547553-2 2008 This study investigated the interactions of four bispyridinium oximes with human erythrocyte acetylcholinesterase (AChE) and their effects on soman- and tabun-poisoned mice. bispyridinium oximes 49-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 18547553-4 2008 These oximes inhibited AchE with inhibitory potency (IC(50)) ranging from 0.02 to 1.0 mM. Oximes 6-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 18547553-6 2008 The protective potency (P(50)) of all oximes in human erythrocyte AChE inhibited by soman and tabun could not be determined. Oximes 38-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 18554581-6 2008 We also recently analysed whether long-term exposure to the cholinesterase inhibitor (ChE-I) donepezil influences the AChE species found in AD CSF. Donepezil 93-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 18554581-7 2008 The marked increase in CSF-AChE activity in AD patients following long-term treatment with donepezil was not paralleled by a rise in this subset of light variants. Donepezil 91-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 18555979-6 2008 To examine whether the introduction of a Cys in the C-terminal region of other alpha/beta-hydrolase fold proteins could promote the same cellular phenotype, we made homologous mutations in acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) and found a similar processing deficiency and intracellular retention (De Jaco et al., J Biol Chem. Cysteine 41-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-209 18555979-6 2008 To examine whether the introduction of a Cys in the C-terminal region of other alpha/beta-hydrolase fold proteins could promote the same cellular phenotype, we made homologous mutations in acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) and found a similar processing deficiency and intracellular retention (De Jaco et al., J Biol Chem. Cysteine 41-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-215 18555980-10 2008 Preliminary results with human and animal whole blood suggest that 20 microM ethopropazine and 500 nM (-) huperzine A can be used for measuring AChE and BChE activities across species. profenamine 77-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 18555980-10 2008 Preliminary results with human and animal whole blood suggest that 20 microM ethopropazine and 500 nM (-) huperzine A can be used for measuring AChE and BChE activities across species. huperzine A 102-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 18555982-2 2008 It has been demonstrated that the efficacy of an oxime primarily depends on its ability to reactivate nerve agent-inhibited acetylcholinesterase (AChE). Oximes 49-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 18555982-3 2008 If the in vitro oxime reactivation of nerve agent-inhibited animal AChE is similar to that of human AChE, it is likely that the results of an in vivo animal study will reliably extrapolate to humans. Oximes 16-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 18555982-6 2008 Results indicate that oxime reactivation of all three monkey AChEs was very similar to human AChE. Oximes 22-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 18555982-8 2008 Aging rate constants of GF-, GD-, and VR-inhibited monkey AChEs were very similar to human AChE except for GF-inhibited monkey AChEs, which aged 2-3 times faster than the human enzyme. Gadolinium 29-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 18555982-8 2008 Aging rate constants of GF-, GD-, and VR-inhibited monkey AChEs were very similar to human AChE except for GF-inhibited monkey AChEs, which aged 2-3 times faster than the human enzyme. glycylphenylalanine 24-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 18565503-1 2008 Exposure to the organophosphorus nerve agents such as sarin, soman, cyclosarin, and VX causes acute intoxication by inhibiting acetylcholinesterase (AChE), where the serine residue of the active site can attack the phosphorous atom of the organophosphorus agents to form a strong P-O bond. organophosphorus 16-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 18565503-1 2008 Exposure to the organophosphorus nerve agents such as sarin, soman, cyclosarin, and VX causes acute intoxication by inhibiting acetylcholinesterase (AChE), where the serine residue of the active site can attack the phosphorous atom of the organophosphorus agents to form a strong P-O bond. organophosphorus 16-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 18565503-1 2008 Exposure to the organophosphorus nerve agents such as sarin, soman, cyclosarin, and VX causes acute intoxication by inhibiting acetylcholinesterase (AChE), where the serine residue of the active site can attack the phosphorous atom of the organophosphorus agents to form a strong P-O bond. Soman 61-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 18565503-1 2008 Exposure to the organophosphorus nerve agents such as sarin, soman, cyclosarin, and VX causes acute intoxication by inhibiting acetylcholinesterase (AChE), where the serine residue of the active site can attack the phosphorous atom of the organophosphorus agents to form a strong P-O bond. Soman 61-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 18565503-1 2008 Exposure to the organophosphorus nerve agents such as sarin, soman, cyclosarin, and VX causes acute intoxication by inhibiting acetylcholinesterase (AChE), where the serine residue of the active site can attack the phosphorous atom of the organophosphorus agents to form a strong P-O bond. cyclohexyl methylphosphonofluoridate 68-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 18565503-1 2008 Exposure to the organophosphorus nerve agents such as sarin, soman, cyclosarin, and VX causes acute intoxication by inhibiting acetylcholinesterase (AChE), where the serine residue of the active site can attack the phosphorous atom of the organophosphorus agents to form a strong P-O bond. cyclohexyl methylphosphonofluoridate 68-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 18565503-1 2008 Exposure to the organophosphorus nerve agents such as sarin, soman, cyclosarin, and VX causes acute intoxication by inhibiting acetylcholinesterase (AChE), where the serine residue of the active site can attack the phosphorous atom of the organophosphorus agents to form a strong P-O bond. Serine 166-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 18565503-1 2008 Exposure to the organophosphorus nerve agents such as sarin, soman, cyclosarin, and VX causes acute intoxication by inhibiting acetylcholinesterase (AChE), where the serine residue of the active site can attack the phosphorous atom of the organophosphorus agents to form a strong P-O bond. Serine 166-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 18565503-1 2008 Exposure to the organophosphorus nerve agents such as sarin, soman, cyclosarin, and VX causes acute intoxication by inhibiting acetylcholinesterase (AChE), where the serine residue of the active site can attack the phosphorous atom of the organophosphorus agents to form a strong P-O bond. Phosphinidene 215-226 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 18565503-1 2008 Exposure to the organophosphorus nerve agents such as sarin, soman, cyclosarin, and VX causes acute intoxication by inhibiting acetylcholinesterase (AChE), where the serine residue of the active site can attack the phosphorous atom of the organophosphorus agents to form a strong P-O bond. Phosphinidene 215-226 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 18565503-1 2008 Exposure to the organophosphorus nerve agents such as sarin, soman, cyclosarin, and VX causes acute intoxication by inhibiting acetylcholinesterase (AChE), where the serine residue of the active site can attack the phosphorous atom of the organophosphorus agents to form a strong P-O bond. organophosphorus 239-255 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 18565503-1 2008 Exposure to the organophosphorus nerve agents such as sarin, soman, cyclosarin, and VX causes acute intoxication by inhibiting acetylcholinesterase (AChE), where the serine residue of the active site can attack the phosphorous atom of the organophosphorus agents to form a strong P-O bond. organophosphorus 239-255 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 18565503-2 2008 The purpose of the present study was to evaluate new oxime antidotes to reactivate the inhibited AChE. Oximes 53-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 18565503-5 2008 The reactivation potencies of the bis-pyridinium oximes connected with a (CH(2))(n) linker between the two quaternary nitrogen atoms were evaluated with housefly (HF) AChE inhibited by diisopropyl fluorophosphates (DFP) and by paraoxon. bis-pyridinium oximes 34-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 18565503-5 2008 The reactivation potencies of the bis-pyridinium oximes connected with a (CH(2))(n) linker between the two quaternary nitrogen atoms were evaluated with housefly (HF) AChE inhibited by diisopropyl fluorophosphates (DFP) and by paraoxon. Isoflurophate 185-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 18571631-0 2008 Novel isosorbide di-ester compounds as inhibitors of acetylcholinesterase. isosorbide di-ester 6-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 18571631-1 2008 We report herein that a variety of isosorbide di-esters, previously reported to be novel substrates for butyrylcholinesterase (BuChE, EC 3.1.1.8), are in fact inhibitors of the homologous enzyme acetylcholinesterase (AChE), with IC(50) values in the micromolar range. isosorbide di-esters 35-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-215 18571631-1 2008 We report herein that a variety of isosorbide di-esters, previously reported to be novel substrates for butyrylcholinesterase (BuChE, EC 3.1.1.8), are in fact inhibitors of the homologous enzyme acetylcholinesterase (AChE), with IC(50) values in the micromolar range. isosorbide di-esters 35-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 217-221 18572153-0 2008 Protection of red blood cell acetylcholinesterase by oral huperzine A against ex vivo soman exposure: next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase. huperzine A 58-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 18572153-1 2008 As part of a phase Ib clinical trial to determine the tolerability and safety of the highly specific acetylcholinesterase (AChE) inhibitor huperzine A, twelve (12) healthy elderly individuals received an escalating dose regimen of huperzine A (100, 200, 300, and 400 microg doses, twice daily for a week at each dose), with three (3) individuals as controls receiving a placebo. huperzine A 139-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 18572153-8 2008 Eluted blood was diluted in buffer, and aliquots taken at various time intervals for AChE and BChE activity measurement to determine the time taken to achieve full return in activity of the free enzyme (dissociation from the active site of AChE by huperzine A), and thus the proportion of AChE that can be protected from soman exposure. huperzine A 248-259 acetylcholinesterase (Cartwright blood group) Homo sapiens 240-244 18572153-8 2008 Eluted blood was diluted in buffer, and aliquots taken at various time intervals for AChE and BChE activity measurement to determine the time taken to achieve full return in activity of the free enzyme (dissociation from the active site of AChE by huperzine A), and thus the proportion of AChE that can be protected from soman exposure. huperzine A 248-259 acetylcholinesterase (Cartwright blood group) Homo sapiens 240-244 18572153-9 2008 Huperzine A-inhibited red blood cell (RBC) AChE activity was restored almost to the level that was initially inhibited by the drug. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 18572153-10 2008 The increased doses of huperzine A used were well tolerated by these patients and in this ex vivo study sequestered more red blood cell AChE than has been previously demonstrated for pyridostigmine bromide (PB), indicating the potential improved prophylaxis against organophosphate (OP) poisoning. huperzine A 23-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 18573242-9 2008 Ethanol and aqueous extracts of six herbs were found to have high AChE inhibitory activities in a dose-dependent manner. Ethanol 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 18582854-2 2008 In order to relate bambuterol selectivity and stereoselectivity of BChE and acetylcholinesterase (AChE, EC 3.1.1.7) of different species, we studied the inhibition of human, mouse, and horse BChE, as well as AChE of human and mouse by (R)- and (S)-bambuterol. bambuterol 19-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 18582854-3 2008 AChE and BChE of all studied species were progressively inhibited by both bambuterol enantiomers, with a preference for the (R)-bambuterol whose inhibition rate constants were about five times higher than that of (S)-bambuterol. (R)-bambuterol 124-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 18582854-3 2008 AChE and BChE of all studied species were progressively inhibited by both bambuterol enantiomers, with a preference for the (R)-bambuterol whose inhibition rate constants were about five times higher than that of (S)-bambuterol. bambuterol 213-227 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 18585370-2 2008 Compounds with triethylpentylammoniumalkyl groups behaved as typical reversible inhibitors of acetylcholinesterase (AChE) (pI(50) 3.20-6.22) and butyrylcholinesterase (BuChE) (pI(50) 3.05-5.71). triethylpentylammoniumalkyl 15-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 18585370-2 2008 Compounds with triethylpentylammoniumalkyl groups behaved as typical reversible inhibitors of acetylcholinesterase (AChE) (pI(50) 3.20-6.22) and butyrylcholinesterase (BuChE) (pI(50) 3.05-5.71). triethylpentylammoniumalkyl 15-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 18586019-1 2008 In accordance with its biological role, termination of neurotransmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase is one of nature"s most efficient enzymes. Acetylcholine 142-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-177 18588863-7 2008 AChE was 90-95% inhibited by all Flu-OPs (0.36-0.9(M) and then was reactivated by either 2-PAM or TOX. flu-ops 33-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 18588863-7 2008 AChE was 90-95% inhibited by all Flu-OPs (0.36-0.9(M) and then was reactivated by either 2-PAM or TOX. Obidoxime Chloride 98-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 18588863-9 2008 TOX was also shown to be a better reactivator than 2-PAM for AChE inhibited by the nerve agents VX and cyclosarin. Obidoxime Chloride 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 18588863-9 2008 TOX was also shown to be a better reactivator than 2-PAM for AChE inhibited by the nerve agents VX and cyclosarin. cyclohexyl methylphosphonofluoridate 103-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 18588863-10 2008 PMP-AChE could not be reactivated by either TOX or 2-PAM, similarly to aging of PMP-AChE formed by inhibition with soman. pmp 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 18602908-0 2008 Monitoring the reaction of carbachol with acetylcholinesterase by thioflavin T fluorescence and acetylthiocholine hydrolysis. Carbachol 27-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 18602908-0 2008 Monitoring the reaction of carbachol with acetylcholinesterase by thioflavin T fluorescence and acetylthiocholine hydrolysis. thioflavin T 66-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 18602908-0 2008 Monitoring the reaction of carbachol with acetylcholinesterase by thioflavin T fluorescence and acetylthiocholine hydrolysis. Acetylthiocholine 96-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 18602908-3 2008 Carbamates are very poor substrates that, like other AChE substrates, form an initial enzyme-substrate complex and proceed to an acylated enzyme intermediate which is then hydrolyzed. Carbamates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 18602908-5 2008 Here we show that the reaction of carbachol (carbamoylcholine) with AChE can be monitored both with acetylthiocholine as a reporter substrate and with thioflavin T as a fluorescent reporter group. Carbachol 34-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 18602908-5 2008 Here we show that the reaction of carbachol (carbamoylcholine) with AChE can be monitored both with acetylthiocholine as a reporter substrate and with thioflavin T as a fluorescent reporter group. Carbachol 45-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 18602908-5 2008 Here we show that the reaction of carbachol (carbamoylcholine) with AChE can be monitored both with acetylthiocholine as a reporter substrate and with thioflavin T as a fluorescent reporter group. Acetylthiocholine 100-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 18602908-5 2008 Here we show that the reaction of carbachol (carbamoylcholine) with AChE can be monitored both with acetylthiocholine as a reporter substrate and with thioflavin T as a fluorescent reporter group. thioflavin T 151-163 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 18602908-6 2008 The fluorescence of thioflavin T is strongly enhanced when it binds to the P-site of AChE, and this fluorescence is partially quenched when a second ligand binds to the A-site to form a ternary complex. thioflavin T 20-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 18617161-0 2008 Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro. Oximes 19-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 18617161-0 2008 Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro. Paraoxon 106-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 18617161-1 2008 Organophosphorus pesticides (e.g. chlorpyrifos, malathion, and parathion) and nerve agents (sarin, tabun, and VX) are highly toxic organophosphorus compounds with strong inhibition potency against two key enzymes in the human body-acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8). organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-251 18617161-1 2008 Organophosphorus pesticides (e.g. chlorpyrifos, malathion, and parathion) and nerve agents (sarin, tabun, and VX) are highly toxic organophosphorus compounds with strong inhibition potency against two key enzymes in the human body-acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8). organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 253-257 18617161-1 2008 Organophosphorus pesticides (e.g. chlorpyrifos, malathion, and parathion) and nerve agents (sarin, tabun, and VX) are highly toxic organophosphorus compounds with strong inhibition potency against two key enzymes in the human body-acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8). Chlorpyrifos 34-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-251 18617161-1 2008 Organophosphorus pesticides (e.g. chlorpyrifos, malathion, and parathion) and nerve agents (sarin, tabun, and VX) are highly toxic organophosphorus compounds with strong inhibition potency against two key enzymes in the human body-acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8). Chlorpyrifos 34-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 253-257 18617161-1 2008 Organophosphorus pesticides (e.g. chlorpyrifos, malathion, and parathion) and nerve agents (sarin, tabun, and VX) are highly toxic organophosphorus compounds with strong inhibition potency against two key enzymes in the human body-acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8). Malathion 48-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-251 18617161-1 2008 Organophosphorus pesticides (e.g. chlorpyrifos, malathion, and parathion) and nerve agents (sarin, tabun, and VX) are highly toxic organophosphorus compounds with strong inhibition potency against two key enzymes in the human body-acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8). Malathion 48-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 253-257 18617161-1 2008 Organophosphorus pesticides (e.g. chlorpyrifos, malathion, and parathion) and nerve agents (sarin, tabun, and VX) are highly toxic organophosphorus compounds with strong inhibition potency against two key enzymes in the human body-acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8). Parathion 63-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-251 18617161-1 2008 Organophosphorus pesticides (e.g. chlorpyrifos, malathion, and parathion) and nerve agents (sarin, tabun, and VX) are highly toxic organophosphorus compounds with strong inhibition potency against two key enzymes in the human body-acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8). Parathion 63-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 253-257 18617161-1 2008 Organophosphorus pesticides (e.g. chlorpyrifos, malathion, and parathion) and nerve agents (sarin, tabun, and VX) are highly toxic organophosphorus compounds with strong inhibition potency against two key enzymes in the human body-acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8). organophosphorus 131-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-251 18617161-1 2008 Organophosphorus pesticides (e.g. chlorpyrifos, malathion, and parathion) and nerve agents (sarin, tabun, and VX) are highly toxic organophosphorus compounds with strong inhibition potency against two key enzymes in the human body-acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BuChE; EC 3.1.1.8). organophosphorus 131-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 253-257 18617161-3 2008 For the recovery of inhibited AChE, derivatives from the group of pyridinium or bispyridinium aldoximes (called oximes) are used. pyridine 66-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 18617161-3 2008 For the recovery of inhibited AChE, derivatives from the group of pyridinium or bispyridinium aldoximes (called oximes) are used. bispyridinium aldoximes 80-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 18617161-3 2008 For the recovery of inhibited AChE, derivatives from the group of pyridinium or bispyridinium aldoximes (called oximes) are used. Oximes 97-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 18617161-5 2008 In this study, we have tested potency of selected cholinesterase reactivators (pralidoxime, obidoxime, trimedoxime, methoxime and H-oxime HI-6) to reactivate human erythrocyte AChE and human plasma BuChE inhibited by pesticide paraoxon. pralidoxime 79-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 18617161-7 2008 Results demonstrated that obidoxime (96.8%) and trimedoxime (86%) only reached sufficient reactivation efficacy in case of paraoxon-inhibited AChE. Obidoxime Chloride 26-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 18617161-7 2008 Results demonstrated that obidoxime (96.8%) and trimedoxime (86%) only reached sufficient reactivation efficacy in case of paraoxon-inhibited AChE. Trimedoxime 48-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 18617161-7 2008 Results demonstrated that obidoxime (96.8%) and trimedoxime (86%) only reached sufficient reactivation efficacy in case of paraoxon-inhibited AChE. Paraoxon 123-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 19227834-0 2008 Inhibition of acetylcholinesterase activity by dihydro-beta-agarofuran sesquiterpenes isolated from Chilean Celastraceae. dihydro-beta-agarofuran sesquiterpenes 47-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 18971479-1 2008 Using 24 h of total sleep deprivation to perturb normal cognitive function, we conducted a double-blind, placebo-controlled crossover study to evaluate the effect of the acetylcholinesterase inhibitor, donepezil, on behavioral performance and task-related brain activation in 28 healthy, young, adult volunteers. Donepezil 202-211 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-190 18817366-6 2008 The most potent and selective compound was isosorbide-2-benzyl carbamate-5-benzoate with an IC 50 of 4.3 nM for BuChE and >50000 fold selectivity over human erythrocyte AChE. isosorbide-2-benzyl carbamate-5-benzoate 43-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-176 18804659-8 2008 The most significant identification was based on methamidophos inhibited AChE reactivation by HI-6 or pralidoxime and paraoxon-ethyl inhibited AChE by obidoxime; moreover, identification of trichlorfon and paraoxon-methyl was possible, too. Paraoxon 118-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 18804659-8 2008 The most significant identification was based on methamidophos inhibited AChE reactivation by HI-6 or pralidoxime and paraoxon-ethyl inhibited AChE by obidoxime; moreover, identification of trichlorfon and paraoxon-methyl was possible, too. Obidoxime Chloride 151-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 18804659-8 2008 The most significant identification was based on methamidophos inhibited AChE reactivation by HI-6 or pralidoxime and paraoxon-ethyl inhibited AChE by obidoxime; moreover, identification of trichlorfon and paraoxon-methyl was possible, too. Obidoxime Chloride 151-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 18804659-8 2008 The most significant identification was based on methamidophos inhibited AChE reactivation by HI-6 or pralidoxime and paraoxon-ethyl inhibited AChE by obidoxime; moreover, identification of trichlorfon and paraoxon-methyl was possible, too. Trichlorfon 190-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 18692909-0 2008 Suppression of neuroinflammation and immunomodulation by the acetylcholinesterase inhibitor rivastigmine. Rivastigmine 92-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 18692909-1 2008 In this study we determined the influence of cholinergic up-regulation by rivastigmine, an acetylcholinesterase inhibitor, on central nervous system inflammation. Rivastigmine 74-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 18804623-0 2008 Alumina sol-gel/sonogel-carbon electrode based on acetylcholinesterase for detection of organophosphorus pesticides. Carbon 24-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 18804623-0 2008 Alumina sol-gel/sonogel-carbon electrode based on acetylcholinesterase for detection of organophosphorus pesticides. organophosphorus 88-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 18804623-1 2008 Two new amperometric biosensors based on immobilization of acetylcholinesterase on a sonogel-carbon electrode for detection of organophosphorous compounds are proposed. Carbon 93-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 18804623-1 2008 Two new amperometric biosensors based on immobilization of acetylcholinesterase on a sonogel-carbon electrode for detection of organophosphorous compounds are proposed. organophosphorous compounds 127-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 18804623-3 2008 The first biosensor was obtained by simple entrapping acetylcholinesterase in Al(2)O(3) sol-gel matrix on the sonogel-carbon. Aluminum Oxide 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 18804623-3 2008 The first biosensor was obtained by simple entrapping acetylcholinesterase in Al(2)O(3) sol-gel matrix on the sonogel-carbon. Carbon 118-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 18804659-0 2008 Improvement of acetylcholinesterase-based assay for organophosphates in way of identification by reactivators. Organophosphates 52-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 18804659-2 2008 Detection of organophosphates is frequently based on following acetylcholinesterase (AChE) inhibition. Organophosphates 13-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 18804659-2 2008 Detection of organophosphates is frequently based on following acetylcholinesterase (AChE) inhibition. Organophosphates 13-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 18804659-6 2008 Reactivation was realized in the 96-wells photometric microplates and activity of human recombinant AChE was followed by reaction of Ellman"s reagent with one of enzyme digestion product: thiocholine. Thiocholine 188-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 18804659-8 2008 The most significant identification was based on methamidophos inhibited AChE reactivation by HI-6 or pralidoxime and paraoxon-ethyl inhibited AChE by obidoxime; moreover, identification of trichlorfon and paraoxon-methyl was possible, too. methamidophos 49-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 18804659-8 2008 The most significant identification was based on methamidophos inhibited AChE reactivation by HI-6 or pralidoxime and paraoxon-ethyl inhibited AChE by obidoxime; moreover, identification of trichlorfon and paraoxon-methyl was possible, too. methamidophos 49-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 18804659-8 2008 The most significant identification was based on methamidophos inhibited AChE reactivation by HI-6 or pralidoxime and paraoxon-ethyl inhibited AChE by obidoxime; moreover, identification of trichlorfon and paraoxon-methyl was possible, too. asoxime chloride 94-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 18639532-7 2008 Additionally, NO donor spermine NONOate could inhibit the AChE activity in brain homogenates in a concentration-dependent manner, which further substantiate that nitric oxide produced during post hypoxia re-oxygenation, primarily contributes to the observed inhibition of cortical AChE activity. spermine nitric oxide complex 23-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 18639532-7 2008 Additionally, NO donor spermine NONOate could inhibit the AChE activity in brain homogenates in a concentration-dependent manner, which further substantiate that nitric oxide produced during post hypoxia re-oxygenation, primarily contributes to the observed inhibition of cortical AChE activity. spermine nitric oxide complex 23-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 281-285 18639532-7 2008 Additionally, NO donor spermine NONOate could inhibit the AChE activity in brain homogenates in a concentration-dependent manner, which further substantiate that nitric oxide produced during post hypoxia re-oxygenation, primarily contributes to the observed inhibition of cortical AChE activity. Nitric Oxide 162-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 18639532-7 2008 Additionally, NO donor spermine NONOate could inhibit the AChE activity in brain homogenates in a concentration-dependent manner, which further substantiate that nitric oxide produced during post hypoxia re-oxygenation, primarily contributes to the observed inhibition of cortical AChE activity. Nitric Oxide 162-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 281-285 18468882-0 2008 Development of a bifunctional sensor using haptenized acetylcholinesterase and application for the detection of cocaine and organophosphates. Cocaine 112-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 18468882-0 2008 Development of a bifunctional sensor using haptenized acetylcholinesterase and application for the detection of cocaine and organophosphates. Organophosphates 124-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 18468882-1 2008 We developed a dual piezoelectric/amperometric sensor for the detection of two unrelated analytes in one experiment that uses propidium to anchor acetylcholinesterases (AChE) at the surface. Propidium 126-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 18468882-4 2008 For this reason the cocaine derivative benzoylecgonine (BZE) was coupled via a 10A long hydrophilic linker - 1,8-diamino-3,4-dioxaoctane - to carboxylic groups of the AChE after EDC/NHS activation. Cocaine 20-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 18468882-4 2008 For this reason the cocaine derivative benzoylecgonine (BZE) was coupled via a 10A long hydrophilic linker - 1,8-diamino-3,4-dioxaoctane - to carboxylic groups of the AChE after EDC/NHS activation. benzoylecgonine 39-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 18468882-4 2008 For this reason the cocaine derivative benzoylecgonine (BZE) was coupled via a 10A long hydrophilic linker - 1,8-diamino-3,4-dioxaoctane - to carboxylic groups of the AChE after EDC/NHS activation. benzoylecgonine 56-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 18468882-4 2008 For this reason the cocaine derivative benzoylecgonine (BZE) was coupled via a 10A long hydrophilic linker - 1,8-diamino-3,4-dioxaoctane - to carboxylic groups of the AChE after EDC/NHS activation. 1,8-diamino-3,4-dioxaoctane 109-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 18468882-8 2008 Furthermore it was also shown that other cocaine-binding enzymes, e.g., butyrylcholinesterase, can bind to the modified BZE-AChE. Cocaine 41-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-128 18803156-3 2008 CASE REPORTS: Four patients with CADASIL and dementia were treated with the acetylcholinesterase inhibitor galantamine and we assessed cognitive, behavioral, functional and the caregiver burden aspects. Galantamine 107-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 18758020-1 2008 The title compound, C(14)H(14)ClN, is a chloro analogue of tacrine, an acetylcholinesterase inhibitor. Sodium Hypochlorite 40-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 18758020-1 2008 The title compound, C(14)H(14)ClN, is a chloro analogue of tacrine, an acetylcholinesterase inhibitor. Tacrine 59-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 18653726-6 2008 In contrast, two acetylcholinesterase inhibitors (eserine-hemisulfate and bis-9-amino-1,2,3,4-tetrahydroacridine) increased proliferation by 2.5- and 2-fold, respectively (P<0.005). eserine-hemisulfate 50-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 18653726-6 2008 In contrast, two acetylcholinesterase inhibitors (eserine-hemisulfate and bis-9-amino-1,2,3,4-tetrahydroacridine) increased proliferation by 2.5- and 2-fold, respectively (P<0.005). bis-9-amino-1,2,3,4-tetrahydroacridine 74-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 18781015-4 2008 The FET-based immunoassay was constructed by combining the 11-FUT modified-FET sensor with the enzyme-linked immunosorbent assay (ELISA), in which the enzyme chemistry of acetylcholinesterase (AChE) was used to generate a thiol compound. Sulfhydryl Compounds 222-227 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-191 18781015-4 2008 The FET-based immunoassay was constructed by combining the 11-FUT modified-FET sensor with the enzyme-linked immunosorbent assay (ELISA), in which the enzyme chemistry of acetylcholinesterase (AChE) was used to generate a thiol compound. Sulfhydryl Compounds 222-227 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-197 18781015-5 2008 The 11-FUT modified FET sensor with an AC voltage at 1 MHz superimposed onto the reference electrode detected the AChE-catalyzed product corresponding to a serum concentration of interleukin 1beta from 10 to 5000 pg/mL. 11-fut 4-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 18676153-0 2008 Monoquaternary pyridinium salts with modified side chain-synthesis and evaluation on model of tabun- and paraoxon-inhibited acetylcholinesterase. monoquaternary pyridinium salts 0-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 18676153-1 2008 Acetylcholinesterase reactivators are crucial antidotes for the treatment of organophosphate intoxication. Organophosphates 77-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 18676153-2 2008 Eighteen monoquaternary reactivators of acetylcholinesterase with modified side chain were developed in an effort to extend the properties of pralidoxime. pralidoxime 142-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 18248689-3 2008 We conducted this study in order to determine the safety (adverse events, mood changes, cardiovascular effects) and preliminary efficacy (subjective effects) of the AChE inhibitor rivastigmine (Riv) when tested in combination with Meth. Rivastigmine 180-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 18818443-1 2008 To determine if donepezil, an acetylcholinesterase (AChE) inhibitor, improved the assimilation of cognitive training by older adults with memory complaints, we gave 168 nondemented, community-dwelling volunteers with memory complaints either 5 mg of donepezil (Aricept) or placebo daily for 6 weeks in a randomized, double-blind, placebo-controlled trial. Donepezil 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 18818443-1 2008 To determine if donepezil, an acetylcholinesterase (AChE) inhibitor, improved the assimilation of cognitive training by older adults with memory complaints, we gave 168 nondemented, community-dwelling volunteers with memory complaints either 5 mg of donepezil (Aricept) or placebo daily for 6 weeks in a randomized, double-blind, placebo-controlled trial. Donepezil 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 18818443-6 2008 Physiological tolerance may occur with chronic donepezil treatment and may increase AChE levels; this may be why short-term studies have shown the benefit of AChE inhibitor use in nondemented participants whereas chronic use has failed to enhance cognition. Donepezil 47-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 18515163-0 2008 An investigation of structurally diverse carbamates for acetylcholinesterase (AChE) inhibition using 3D-QSAR analysis. Carbamates 41-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 18515163-0 2008 An investigation of structurally diverse carbamates for acetylcholinesterase (AChE) inhibition using 3D-QSAR analysis. Carbamates 41-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 18515163-1 2008 In order to identify the essential structural features and physicochemical properties for acetylcholinesterase (AChE) inhibitory activity in some carbamate derivatives, the systematic QSAR (Quantitative Structure Activity Relationship) studies (CoMFA, advance CoMFA and CoMSIA) have been carried out on a series of (total 78 molecules) taking 52 and 26 molecules in training and test set, respectively. Carbamates 146-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 18515163-1 2008 In order to identify the essential structural features and physicochemical properties for acetylcholinesterase (AChE) inhibitory activity in some carbamate derivatives, the systematic QSAR (Quantitative Structure Activity Relationship) studies (CoMFA, advance CoMFA and CoMSIA) have been carried out on a series of (total 78 molecules) taking 52 and 26 molecules in training and test set, respectively. Carbamates 146-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 18581151-0 2008 Interpretation of the mechanism of acetylcholinesterase inhibition ability by organophosphorus compounds through a new conformational descriptor. organophosphorus 78-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 18778776-0 2008 Inhibition of acetylcholinesterase by coumarins: the case of coumarin 106. Coumarins 38-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 18778776-0 2008 Inhibition of acetylcholinesterase by coumarins: the case of coumarin 106. coumarin 38-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 18778776-1 2008 In this contribution, from a coumarin library consisting of 29 compounds including natural and synthetic derivatives, an active acetylcholinesterase (AChE) inhibitor (coumarin 106) was found. coumarin 29-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 18778776-1 2008 In this contribution, from a coumarin library consisting of 29 compounds including natural and synthetic derivatives, an active acetylcholinesterase (AChE) inhibitor (coumarin 106) was found. coumarin 29-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 18778776-1 2008 In this contribution, from a coumarin library consisting of 29 compounds including natural and synthetic derivatives, an active acetylcholinesterase (AChE) inhibitor (coumarin 106) was found. coumarin 167-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 18778776-1 2008 In this contribution, from a coumarin library consisting of 29 compounds including natural and synthetic derivatives, an active acetylcholinesterase (AChE) inhibitor (coumarin 106) was found. coumarin 167-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 18778776-5 2008 The follow-up analysis using kinetic studies demonstrated that coumarin 106 displays mixed-type AChE inhibition with a pIC(50)=4.97+/-0.09 and K(i)=2.36+/-0.17 microM. coumarin 63-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 18778776-9 2008 This is the first report where AChE inhibitory activity has been associated with coumarin 106, and proof has been given of its convenience as a lead molecule. coumarin 81-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 27873815-1 2008 An amperometric biosensor based on acetylcholinesterase (AChE) immobilized in gelatin was used to develop an assay for the organophosphate paraoxon. organophosphate paraoxon 123-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 27873815-1 2008 An amperometric biosensor based on acetylcholinesterase (AChE) immobilized in gelatin was used to develop an assay for the organophosphate paraoxon. organophosphate paraoxon 123-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 18662884-1 2008 As a part of our project aimed at developing new agents of potential application in AD, a new series of 2-phenoxy-indan-1-one derivatives which possess alkylamine side chain were designed, synthesized, and evaluated for their inhibitory activity against AChE and BuChE. 2-phenoxy-indan-1-one 104-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 254-258 18662884-1 2008 As a part of our project aimed at developing new agents of potential application in AD, a new series of 2-phenoxy-indan-1-one derivatives which possess alkylamine side chain were designed, synthesized, and evaluated for their inhibitory activity against AChE and BuChE. alkylamine 152-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 254-258 19662147-1 2008 In this study we investigated the structure-activity relationships by using the Electron- Topological Method (ETM) for a class of AChE inhibitors related to tacrine (9-amino-1,2,3,4-tetrahydroacridine) and 11 H-Indeno-[1,2-b]-quinolin-10-ylamine that tetracyclic tacrine analogues, a drug currently in use for the treatment of the AD. Tacrine 157-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 19662147-1 2008 In this study we investigated the structure-activity relationships by using the Electron- Topological Method (ETM) for a class of AChE inhibitors related to tacrine (9-amino-1,2,3,4-tetrahydroacridine) and 11 H-Indeno-[1,2-b]-quinolin-10-ylamine that tetracyclic tacrine analogues, a drug currently in use for the treatment of the AD. Tacrine 166-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 19662147-1 2008 In this study we investigated the structure-activity relationships by using the Electron- Topological Method (ETM) for a class of AChE inhibitors related to tacrine (9-amino-1,2,3,4-tetrahydroacridine) and 11 H-Indeno-[1,2-b]-quinolin-10-ylamine that tetracyclic tacrine analogues, a drug currently in use for the treatment of the AD. h-indeno-[1,2-b]-quinolin-10-ylamine 209-245 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 19662147-1 2008 In this study we investigated the structure-activity relationships by using the Electron- Topological Method (ETM) for a class of AChE inhibitors related to tacrine (9-amino-1,2,3,4-tetrahydroacridine) and 11 H-Indeno-[1,2-b]-quinolin-10-ylamine that tetracyclic tacrine analogues, a drug currently in use for the treatment of the AD. Tacrine 263-270 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 27873775-2 2008 Cyclic voltammetric experiments performed with the SAM-AchE biosensor in phosphate buffer solutions (pH = 7.2) containing acetylthiocholine confirmed the formation of thiocholine and its electrochemical oxidation at Ep = 0.28 V vs Ag/AgCl. Phosphates 73-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 27873775-2 2008 Cyclic voltammetric experiments performed with the SAM-AchE biosensor in phosphate buffer solutions (pH = 7.2) containing acetylthiocholine confirmed the formation of thiocholine and its electrochemical oxidation at Ep = 0.28 V vs Ag/AgCl. Acetylthiocholine 122-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 27873775-2 2008 Cyclic voltammetric experiments performed with the SAM-AchE biosensor in phosphate buffer solutions (pH = 7.2) containing acetylthiocholine confirmed the formation of thiocholine and its electrochemical oxidation at Ep = 0.28 V vs Ag/AgCl. Thiocholine 128-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 27873775-2 2008 Cyclic voltammetric experiments performed with the SAM-AchE biosensor in phosphate buffer solutions (pH = 7.2) containing acetylthiocholine confirmed the formation of thiocholine and its electrochemical oxidation at Ep = 0.28 V vs Ag/AgCl. silver chloride 234-238 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 18242923-5 2008 This report discusses the utilization of neostigmine, an acetylcholinesterase inhibitor, for patients with colonic pseudo-obstruction. Neostigmine 41-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 17379359-1 2008 The effect of galantamine treatment on cortical acetylcholinesterase (AChE) activity and nicotinic receptor binding was investigated by positron emission tomography (PET) in 18 patients with mild Alzheimer"s disease (AD) in relation to galantamine concentration and the patients" cognitive performances. Galantamine 14-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 17379359-1 2008 The effect of galantamine treatment on cortical acetylcholinesterase (AChE) activity and nicotinic receptor binding was investigated by positron emission tomography (PET) in 18 patients with mild Alzheimer"s disease (AD) in relation to galantamine concentration and the patients" cognitive performances. Galantamine 14-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 17379359-5 2008 Inhibition (30-40%) of cortical AChE activity was observed after 3 weeks to 12 months of galantamine treatment. Galantamine 89-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 17379359-9 2008 In conclusion, galantamine caused sustained AChE inhibition for up to 12 months. Galantamine 15-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 18550339-2 2008 Galantamine is an acetylcholinesterase inhibitor that acts as a positive allosteric modulator of nicotine acetylcholine receptors including both the alpha4beta2 and alpha7 subunits. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 18631301-1 2008 This article demonstrates statistical models to quantify the interaction between a carbamate insecticide and acetylcholinesterase. Carbamates 83-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-129 18631301-2 2008 Carbamates are a class of chemicals that inhibit the activity of acetylcholinesterase in humans, an enzyme involved in the regulation of the neurotransmitter acetylcholine. Carbamates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 18511416-9 2008 Complexes with PQ or with PRiMA contained heavy components, which migrated abnormally in SDS-PAGE but probably resulted from disulfide bonding of four AChE(T) subunits with the four upstream cysteines of the associated protein. Disulfides 125-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 18617161-11 2008 From the data obtained, it is clear that only two from currently available oximes (obidoxime and trimedoxime) are good reactivators of paraoxon-inhibited AChE. Oximes 75-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-158 18617161-11 2008 From the data obtained, it is clear that only two from currently available oximes (obidoxime and trimedoxime) are good reactivators of paraoxon-inhibited AChE. Obidoxime Chloride 83-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-158 18617161-11 2008 From the data obtained, it is clear that only two from currently available oximes (obidoxime and trimedoxime) are good reactivators of paraoxon-inhibited AChE. Trimedoxime 97-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-158 18617161-11 2008 From the data obtained, it is clear that only two from currently available oximes (obidoxime and trimedoxime) are good reactivators of paraoxon-inhibited AChE. Paraoxon 135-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-158 18769671-7 2008 Moreover, inherent N-AChE-S was upregulated by stressors inducing protein misfolding and calcium imbalances, both characteristic of AD; and in cortical tissues from AD patients, N-AChE-S overexpression coincides with Tau hyper-phosphorylation. Calcium 89-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 18769671-8 2008 CONCLUSIONS: Together, these findings attribute an apoptogenic role to N-AChE-S and outline a potential value to AChE inhibitor therapeutics in early AD. Nitrogen 2-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 18769671-8 2008 CONCLUSIONS: Together, these findings attribute an apoptogenic role to N-AChE-S and outline a potential value to AChE inhibitor therapeutics in early AD. Nitrogen 2-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 18640842-0 2008 New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties. Tacrine 4-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 18640842-0 2008 New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties. 1,4-dihydropyridine 12-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 18585045-0 2008 Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors. Edrophonium 26-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 18585045-0 2008 Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors. ammonium salts 43-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 18756104-3 2008 Although a number of proteins including protein kinase C, androgen receptor, and acetylcholinesterase were proposed as molecular targets responsible for the activities of decursinol, they are not enough to explain such a diverse biological activity mentioned above. decursin 171-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-101 18483726-1 2008 INTRODUCTION: Donepezil, an acetylcholinesterase inhibitor, has been reported to have an effect that improves cerebral blood flow (CBF) alongside its primary effect on memory function. Donepezil 14-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 18423506-0 2008 Altered binding of thioflavin t to the peripheral anionic site of acetylcholinesterase after phosphorylation of the active site by chlorpyrifos oxon or dichlorvos. thioflavin T 19-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 18423506-0 2008 Altered binding of thioflavin t to the peripheral anionic site of acetylcholinesterase after phosphorylation of the active site by chlorpyrifos oxon or dichlorvos. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 131-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 18423506-2 2008 The current report utilized the peripheral anionic site specific fluorogenic probe thioflavin t to determine if the organophosphates chlorpyrifos oxon and dichlorvos bind to the peripheral anionic site of human recombinant acetylcholinesterase, since certain organophosphates display concentration-dependent kinetics when inhibiting this enzyme. thioflavin T 83-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 223-243 18423506-2 2008 The current report utilized the peripheral anionic site specific fluorogenic probe thioflavin t to determine if the organophosphates chlorpyrifos oxon and dichlorvos bind to the peripheral anionic site of human recombinant acetylcholinesterase, since certain organophosphates display concentration-dependent kinetics when inhibiting this enzyme. Organophosphates 116-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 223-243 18423506-2 2008 The current report utilized the peripheral anionic site specific fluorogenic probe thioflavin t to determine if the organophosphates chlorpyrifos oxon and dichlorvos bind to the peripheral anionic site of human recombinant acetylcholinesterase, since certain organophosphates display concentration-dependent kinetics when inhibiting this enzyme. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 133-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 223-243 18423506-2 2008 The current report utilized the peripheral anionic site specific fluorogenic probe thioflavin t to determine if the organophosphates chlorpyrifos oxon and dichlorvos bind to the peripheral anionic site of human recombinant acetylcholinesterase, since certain organophosphates display concentration-dependent kinetics when inhibiting this enzyme. Organophosphates 259-275 acetylcholinesterase (Cartwright blood group) Homo sapiens 223-243 18423506-3 2008 Incubation of 3 nM acetylcholinesterase active sites with 50 nM or 2000 nM inhibitor altered both the B(max) and K(d) for thioflavin t binding to the peripheral anionic site. thioflavin T 122-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 18248689-3 2008 We conducted this study in order to determine the safety (adverse events, mood changes, cardiovascular effects) and preliminary efficacy (subjective effects) of the AChE inhibitor rivastigmine (Riv) when tested in combination with Meth. Rivastigmine 194-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 18524585-2 2008 Results showed that the novel class of isaindigotone derivatives could inhibit both cholinesterases and the selectivity of AChE over BuChE inhibition was related to the aromatic, the species and length of the alkyl amino side chain of compounds. isaindigotone 39-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 18454940-1 2008 UNLABELLED: Free radical production and high catecholamine levels are implicated with the modulation of acetylcholinesterase (AChE) activity. Free Radicals 12-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 18454940-1 2008 UNLABELLED: Free radical production and high catecholamine levels are implicated with the modulation of acetylcholinesterase (AChE) activity. Free Radicals 12-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 18454940-1 2008 UNLABELLED: Free radical production and high catecholamine levels are implicated with the modulation of acetylcholinesterase (AChE) activity. Catecholamines 45-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 18454940-1 2008 UNLABELLED: Free radical production and high catecholamine levels are implicated with the modulation of acetylcholinesterase (AChE) activity. Catecholamines 45-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 18463882-7 2008 Hirschsprung"s disease was found in 47 (7.2%) patients with characteristic features of absence of ganglion cells, increased AChE activity in the lamina propria and muscularis mucosae, thick nerve fibers in the submucosa, and a lack of NADPH-d-positive fibers in muscularis mucosae. Deuterium 15-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 18463882-8 2008 RSB in 59 (9%) patients presented features of intestinal neuronal dysplasia such as submucosal hyperganglionosis, giant ganglia, ectopic ganglia and increased AChE activity in lamina propria. (1S,5S,6R)-10-(benzo[d]thiazol-6-ylsulfonyl)-5-(methoxymethyl)-3-(pyridin-2-ylethyl)-3,10-diazabicyclo[4.3.1]decan-2-one 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 18438759-1 2008 Galanthamine, an acetylcholinesterase inhibitor used for the treatment of Alzheimer"s disease, and galanthamine-type alkaloids are synthesised in different plants of the family Amaryllidaceae. Galantamine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 18511416-1 2008 Acetylcholinesterase tetramers are inserted in the basal lamina of neuromuscular junctions or anchored in cell membranes through the interaction of four C-terminal t peptides with proline-rich attachment domains (PRADs) of cholinesterase-associated collagen Q (ColQ) or of the transmembrane protein PRiMA (proline-rich membrane anchor). Proline 180-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 18511416-9 2008 Complexes with PQ or with PRiMA contained heavy components, which migrated abnormally in SDS-PAGE but probably resulted from disulfide bonding of four AChE(T) subunits with the four upstream cysteines of the associated protein. Primaquine 15-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 18517184-0 2008 Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. Donepezil 6-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 18517184-1 2008 A novel series of donepezil-tacrine hybrids designed to simultaneously interact with the active, peripheral and midgorge binding sites of acetylcholinesterase (AChE) have been synthesized and tested for their ability to inhibit AChE, butyrylcholinesterase (BChE), and AChE-induced A beta aggregation. Donepezil 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 18517184-1 2008 A novel series of donepezil-tacrine hybrids designed to simultaneously interact with the active, peripheral and midgorge binding sites of acetylcholinesterase (AChE) have been synthesized and tested for their ability to inhibit AChE, butyrylcholinesterase (BChE), and AChE-induced A beta aggregation. Donepezil 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 18517184-1 2008 A novel series of donepezil-tacrine hybrids designed to simultaneously interact with the active, peripheral and midgorge binding sites of acetylcholinesterase (AChE) have been synthesized and tested for their ability to inhibit AChE, butyrylcholinesterase (BChE), and AChE-induced A beta aggregation. Donepezil 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 228-232 18517184-1 2008 A novel series of donepezil-tacrine hybrids designed to simultaneously interact with the active, peripheral and midgorge binding sites of acetylcholinesterase (AChE) have been synthesized and tested for their ability to inhibit AChE, butyrylcholinesterase (BChE), and AChE-induced A beta aggregation. Donepezil 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 228-232 18517184-1 2008 A novel series of donepezil-tacrine hybrids designed to simultaneously interact with the active, peripheral and midgorge binding sites of acetylcholinesterase (AChE) have been synthesized and tested for their ability to inhibit AChE, butyrylcholinesterase (BChE), and AChE-induced A beta aggregation. Tacrine 28-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 18517184-1 2008 A novel series of donepezil-tacrine hybrids designed to simultaneously interact with the active, peripheral and midgorge binding sites of acetylcholinesterase (AChE) have been synthesized and tested for their ability to inhibit AChE, butyrylcholinesterase (BChE), and AChE-induced A beta aggregation. Tacrine 28-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 18517184-1 2008 A novel series of donepezil-tacrine hybrids designed to simultaneously interact with the active, peripheral and midgorge binding sites of acetylcholinesterase (AChE) have been synthesized and tested for their ability to inhibit AChE, butyrylcholinesterase (BChE), and AChE-induced A beta aggregation. Tacrine 28-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 228-232 18517184-1 2008 A novel series of donepezil-tacrine hybrids designed to simultaneously interact with the active, peripheral and midgorge binding sites of acetylcholinesterase (AChE) have been synthesized and tested for their ability to inhibit AChE, butyrylcholinesterase (BChE), and AChE-induced A beta aggregation. Tacrine 28-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 228-232 18517184-2 2008 These compounds consist of a unit of tacrine or 6-chlorotacrine, which occupies the same position as tacrine at the AChE active site, and the 5,6-dimethoxy-2-[(4-piperidinyl)methyl]-1-indanone moiety of donepezil (or the indane derivative thereof), whose position along the enzyme gorge and the peripheral site can be modulated by a suitable tether that connects tacrine and donepezil fragments. 6-chlorotacrine 48-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 18373338-0 2008 Solid-phase synthesis of tris-heteroleptic ruthenium(II) complexes and application to acetylcholinesterase inhibition. Tromethamine 25-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 18373338-0 2008 Solid-phase synthesis of tris-heteroleptic ruthenium(II) complexes and application to acetylcholinesterase inhibition. Ruthenium(II) 43-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 18373338-2 2008 As an application we report the identification of a nanomolar acetylcholinesterase inhibitor from a small ruthenium complex library synthesized on Lanterns. Ruthenium 106-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 18412283-3 2008 Brain AChE activity was measured by [(11)C] N-methylpiperidin-4-yl propionate PET in all subjects. [(11)c] n-methylpiperidin-4-yl propionate 36-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 18560127-9 2008 Acetylcholinesterase inhibitor pyridostigmine bromide (AChEI)-therapy reduced CCR2, CCR5, RANTES and IFNgamma expression and production in AD patients. Pyridostigmine Bromide 31-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 18346819-1 2008 Previous experiments demonstrated that second-based transient increases in choline concentrations measured by electrodes coated with choline oxidase (ChOx) and the amperometric detection of hydrogen peroxide validly indicate the depolarization-dependent release of acetylcholine (ACh) and its hydrolysis by endogenous acetylcholinesterase (AChE). Choline 75-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 318-338 18346819-1 2008 Previous experiments demonstrated that second-based transient increases in choline concentrations measured by electrodes coated with choline oxidase (ChOx) and the amperometric detection of hydrogen peroxide validly indicate the depolarization-dependent release of acetylcholine (ACh) and its hydrolysis by endogenous acetylcholinesterase (AChE). Choline 75-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 340-344 18346819-1 2008 Previous experiments demonstrated that second-based transient increases in choline concentrations measured by electrodes coated with choline oxidase (ChOx) and the amperometric detection of hydrogen peroxide validly indicate the depolarization-dependent release of acetylcholine (ACh) and its hydrolysis by endogenous acetylcholinesterase (AChE). Hydrogen Peroxide 190-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 318-338 18346819-1 2008 Previous experiments demonstrated that second-based transient increases in choline concentrations measured by electrodes coated with choline oxidase (ChOx) and the amperometric detection of hydrogen peroxide validly indicate the depolarization-dependent release of acetylcholine (ACh) and its hydrolysis by endogenous acetylcholinesterase (AChE). Hydrogen Peroxide 190-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 340-344 18346819-1 2008 Previous experiments demonstrated that second-based transient increases in choline concentrations measured by electrodes coated with choline oxidase (ChOx) and the amperometric detection of hydrogen peroxide validly indicate the depolarization-dependent release of acetylcholine (ACh) and its hydrolysis by endogenous acetylcholinesterase (AChE). Acetylcholine 265-278 acetylcholinesterase (Cartwright blood group) Homo sapiens 318-338 18346819-1 2008 Previous experiments demonstrated that second-based transient increases in choline concentrations measured by electrodes coated with choline oxidase (ChOx) and the amperometric detection of hydrogen peroxide validly indicate the depolarization-dependent release of acetylcholine (ACh) and its hydrolysis by endogenous acetylcholinesterase (AChE). Acetylcholine 265-278 acetylcholinesterase (Cartwright blood group) Homo sapiens 340-344 18346819-1 2008 Previous experiments demonstrated that second-based transient increases in choline concentrations measured by electrodes coated with choline oxidase (ChOx) and the amperometric detection of hydrogen peroxide validly indicate the depolarization-dependent release of acetylcholine (ACh) and its hydrolysis by endogenous acetylcholinesterase (AChE). Acetylcholine 280-283 acetylcholinesterase (Cartwright blood group) Homo sapiens 318-338 18346819-1 2008 Previous experiments demonstrated that second-based transient increases in choline concentrations measured by electrodes coated with choline oxidase (ChOx) and the amperometric detection of hydrogen peroxide validly indicate the depolarization-dependent release of acetylcholine (ACh) and its hydrolysis by endogenous acetylcholinesterase (AChE). Acetylcholine 280-283 acetylcholinesterase (Cartwright blood group) Homo sapiens 340-344 18346819-4 2008 If newly released ACh is not completely hydrolyzed by endogenous AChE and capable of reaching the extracellular space, currents recorded via sites equipped with both enzymes should be greater when compared with sites coated with ChOx only. Acetylcholine 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 18587286-0 2008 Prolonged treatment with donepezil increases acetylcholinesterase expression in the central nervous system. Donepezil 25-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 18587286-1 2008 OBJECTIVE: Acetylcholinesterase (AChE), an enzyme catalysing rapid hydrolysis of acetylcholine is the major enzyme in the metabolism of this neurotransmitter in the central nervous system and in the skeletal and smooth muscles. Acetylcholine 81-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 18587286-1 2008 OBJECTIVE: Acetylcholinesterase (AChE), an enzyme catalysing rapid hydrolysis of acetylcholine is the major enzyme in the metabolism of this neurotransmitter in the central nervous system and in the skeletal and smooth muscles. Acetylcholine 81-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 18587286-2 2008 Donepezil is a reversible, primarily non-competitive, selective inhibitor of AChE used in patients with Alzheimer"s disease for the improvement of cognitive deficits. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 18587286-3 2008 We hypothesized that prolonged treatment with donepezil could increase AChE mRNA levels and AChE activity in the central nervous system. Donepezil 46-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 18587286-3 2008 We hypothesized that prolonged treatment with donepezil could increase AChE mRNA levels and AChE activity in the central nervous system. Donepezil 46-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 18587286-4 2008 METHODS: The levels of AChE mRNA and AChE activity in the brain sections of 6 animals treated for 28 days with donepezil (2 mg/kg s.c.) were visualized by an autoradiographic method of in situ hybridization and by Koelle histochemical staining, respectively, and compared with 6 control animals treated with physiologic saline. Donepezil 111-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 18587286-4 2008 METHODS: The levels of AChE mRNA and AChE activity in the brain sections of 6 animals treated for 28 days with donepezil (2 mg/kg s.c.) were visualized by an autoradiographic method of in situ hybridization and by Koelle histochemical staining, respectively, and compared with 6 control animals treated with physiologic saline. Donepezil 111-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 18587286-6 2008 RESULTS: We observed that 28-day treatment with donepezil in comparison to control treatment increased hippocampal AChE mRNA levels and AChE activity. Donepezil 48-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 18587286-6 2008 RESULTS: We observed that 28-day treatment with donepezil in comparison to control treatment increased hippocampal AChE mRNA levels and AChE activity. Donepezil 48-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 18587286-8 2008 Further preclinical and clinical data are needed to evaluate the relative impact of the up-regulation of AChE activity on the outcome of prolonged treatment of AD patients with donepezil. Donepezil 177-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 18363334-4 2008 This PDMS-PDDA/AuNPs film shows different adsorption sites to choline oxidase (ChO) and AChE; after incubation with ChO, the polymer-gold nanocomposite film also shows excellent adsorption ability to AChE. Polymers 125-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 18363334-4 2008 This PDMS-PDDA/AuNPs film shows different adsorption sites to choline oxidase (ChO) and AChE; after incubation with ChO, the polymer-gold nanocomposite film also shows excellent adsorption ability to AChE. Polymers 125-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-204 18384757-0 2008 Reactions of isodimethoate with human red cell acetylcholinesterase. Isodimethoate 13-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 18384757-3 2008 Isodimethoate shows an inhibition rate constant towards human red blood cell acetylcholinesterase (AChE) of 2.3x10(3) M(-1) min(-1) (pH 7.4, 37 degrees C), indicating a somewhat higher potency than found with omethoate, the CYP450-mediated active metabolite of pure dimethoate. Isodimethoate 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 18384757-3 2008 Isodimethoate shows an inhibition rate constant towards human red blood cell acetylcholinesterase (AChE) of 2.3x10(3) M(-1) min(-1) (pH 7.4, 37 degrees C), indicating a somewhat higher potency than found with omethoate, the CYP450-mediated active metabolite of pure dimethoate. Isodimethoate 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 18384757-3 2008 Isodimethoate shows an inhibition rate constant towards human red blood cell acetylcholinesterase (AChE) of 2.3x10(3) M(-1) min(-1) (pH 7.4, 37 degrees C), indicating a somewhat higher potency than found with omethoate, the CYP450-mediated active metabolite of pure dimethoate. dimethoxon 209-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 18384757-3 2008 Isodimethoate shows an inhibition rate constant towards human red blood cell acetylcholinesterase (AChE) of 2.3x10(3) M(-1) min(-1) (pH 7.4, 37 degrees C), indicating a somewhat higher potency than found with omethoate, the CYP450-mediated active metabolite of pure dimethoate. dimethoxon 209-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 18384757-3 2008 Isodimethoate shows an inhibition rate constant towards human red blood cell acetylcholinesterase (AChE) of 2.3x10(3) M(-1) min(-1) (pH 7.4, 37 degrees C), indicating a somewhat higher potency than found with omethoate, the CYP450-mediated active metabolite of pure dimethoate. Dimethoate 3-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 18384757-3 2008 Isodimethoate shows an inhibition rate constant towards human red blood cell acetylcholinesterase (AChE) of 2.3x10(3) M(-1) min(-1) (pH 7.4, 37 degrees C), indicating a somewhat higher potency than found with omethoate, the CYP450-mediated active metabolite of pure dimethoate. Dimethoate 3-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 18384757-4 2008 Isodimethoate-inhibited AChE shows fast spontaneous reactivation and aging kinetics (half-life 2.3 and 25 min, respectively). Isodimethoate 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 18384757-8 2008 These properties make isodimethoate a hit-and-run agent that renders part of AChE non-reactivatable within a short period of time. Isodimethoate 22-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 18384757-9 2008 The clinical consequences of exposure to or intentional ingestion of isodimethoate-containing dimethoate formulations are a partly untractable AChE shortly after incorporation. Isodimethoate 69-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 18384757-9 2008 The clinical consequences of exposure to or intentional ingestion of isodimethoate-containing dimethoate formulations are a partly untractable AChE shortly after incorporation. Dimethoate 72-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 18384757-10 2008 In fact, aging of AChE in dimethoate-poisoned patients on admission was much more advanced than expected from the reaction with omethoate. Dimethoate 26-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 18384757-10 2008 In fact, aging of AChE in dimethoate-poisoned patients on admission was much more advanced than expected from the reaction with omethoate. dimethoxon 128-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 18470725-4 2008 Finally, our observations suggest that NaBT-induced differentiation of intestinal cells involves AChE-induced cell cycle arrest. NABT 39-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 18235987-6 2008 The novel compound, tetrahydrofurobenzofuran cymserine (THFBFC), is derived from our effort to produce a potent and BuChE-selective inhibitor as a candidate to test the hypothesis that BuChE-Is would be efficacious and better tolerated than AChE-Is in AD. tetrahydrofurobenzofuran cymserine 20-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 241-245 18235987-6 2008 The novel compound, tetrahydrofurobenzofuran cymserine (THFBFC), is derived from our effort to produce a potent and BuChE-selective inhibitor as a candidate to test the hypothesis that BuChE-Is would be efficacious and better tolerated than AChE-Is in AD. tetrahydrofurobenzofuran cymserine 56-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 241-245 18438759-1 2008 Galanthamine, an acetylcholinesterase inhibitor used for the treatment of Alzheimer"s disease, and galanthamine-type alkaloids are synthesised in different plants of the family Amaryllidaceae. galanthamine-type alkaloids 99-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 18396898-5 2008 We report the inhibitory potency of fluorogenic organophosphorus compounds with three different leaving groups [3-chloro-7-oxy-4-methylcoumarin, 7-oxy-4-methylcoumarin, 7-oxy-4-(trifluoromethyl)coumarin] toward human acetylcholinesterase (AChE) and report kinetic data for the enzymatic hydrolysis of these compounds by PON1 and DFPase. organophosphorus 48-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 217-237 18396898-5 2008 We report the inhibitory potency of fluorogenic organophosphorus compounds with three different leaving groups [3-chloro-7-oxy-4-methylcoumarin, 7-oxy-4-methylcoumarin, 7-oxy-4-(trifluoromethyl)coumarin] toward human acetylcholinesterase (AChE) and report kinetic data for the enzymatic hydrolysis of these compounds by PON1 and DFPase. organophosphorus 48-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 239-243 18564794-3 2008 The morbidity and mortality with organophosphate poisoning is relatively high despite the use of atropine as specific antidotal therapy and oximes to reactivate acetylcholinesterase. Organophosphates 33-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-181 18564794-3 2008 The morbidity and mortality with organophosphate poisoning is relatively high despite the use of atropine as specific antidotal therapy and oximes to reactivate acetylcholinesterase. Oximes 140-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-181 18385943-1 2008 We show that H2O2 increases acetylcholinesterase (AChE) expression via transcriptional activation through c-Jun N-terminal kinase (JNK), since the JNK inhibitor SP600125, but not the extracellular signal-regulated kinase (ERK) pathway inhibitor PD98059 or p38 kinase inhibitor SB203580, attenuated H2O2-induced AChE expression and its promoter activity. Hydrogen Peroxide 13-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 18385943-1 2008 We show that H2O2 increases acetylcholinesterase (AChE) expression via transcriptional activation through c-Jun N-terminal kinase (JNK), since the JNK inhibitor SP600125, but not the extracellular signal-regulated kinase (ERK) pathway inhibitor PD98059 or p38 kinase inhibitor SB203580, attenuated H2O2-induced AChE expression and its promoter activity. Hydrogen Peroxide 13-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 311-315 18385943-1 2008 We show that H2O2 increases acetylcholinesterase (AChE) expression via transcriptional activation through c-Jun N-terminal kinase (JNK), since the JNK inhibitor SP600125, but not the extracellular signal-regulated kinase (ERK) pathway inhibitor PD98059 or p38 kinase inhibitor SB203580, attenuated H2O2-induced AChE expression and its promoter activity. pyrazolanthrone 161-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 18385943-1 2008 We show that H2O2 increases acetylcholinesterase (AChE) expression via transcriptional activation through c-Jun N-terminal kinase (JNK), since the JNK inhibitor SP600125, but not the extracellular signal-regulated kinase (ERK) pathway inhibitor PD98059 or p38 kinase inhibitor SB203580, attenuated H2O2-induced AChE expression and its promoter activity. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 245-252 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 18385943-1 2008 We show that H2O2 increases acetylcholinesterase (AChE) expression via transcriptional activation through c-Jun N-terminal kinase (JNK), since the JNK inhibitor SP600125, but not the extracellular signal-regulated kinase (ERK) pathway inhibitor PD98059 or p38 kinase inhibitor SB203580, attenuated H2O2-induced AChE expression and its promoter activity. SB 203580 277-285 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 18385943-1 2008 We show that H2O2 increases acetylcholinesterase (AChE) expression via transcriptional activation through c-Jun N-terminal kinase (JNK), since the JNK inhibitor SP600125, but not the extracellular signal-regulated kinase (ERK) pathway inhibitor PD98059 or p38 kinase inhibitor SB203580, attenuated H2O2-induced AChE expression and its promoter activity. Hydrogen Peroxide 298-302 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 18385943-2 2008 Overexpression of hemagglutinin (HA)-JNK increases H2O2-induced AChE expression and its promoter activity, whereas the dominant negative mutant form of JNK suppressed H2O2-induced AChE expression and promoter activity. Hydrogen Peroxide 51-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 18385943-2 2008 Overexpression of hemagglutinin (HA)-JNK increases H2O2-induced AChE expression and its promoter activity, whereas the dominant negative mutant form of JNK suppressed H2O2-induced AChE expression and promoter activity. Hydrogen Peroxide 167-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 18385943-5 2008 Taken together, our results strongly suggest that H2O2 induces AChE expression via the JNK/AP1/ ATF2 signaling pathway. Hydrogen Peroxide 50-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 18344198-1 2008 Oximes are enzyme reactivators used in treating poisoning with organophosphorus cholinesterase (AChE) inhibitors. Oximes 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 18344198-2 2008 The oxime dose which can be safely administered is limited by the intrinsic toxicity of the substances such as their own AChE-inhibiting tendency. Oximes 4-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 18343962-1 2008 The reaction mechanism of acetylcholine hydrolysis by acetylcholinesterase, including both acylation and deacylation stages from the enzyme-substrate (ES) to the enzyme-product (EP) molecular complexes, is examined by using an ab initio type quantum mechanical - molecular mechanical (QM/MM) approach. Acetylcholine 26-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 18194150-1 2008 5-Hydroxytryptamine (5-HT4) receptor agonists increase gastrointestinal (GI) motility by enhancing enteric acetylcholine release which is then metabolized by acetylcholinesterase (AChE) to inactive metabolites. Acetylcholine 107-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-178 18363334-5 2008 Moreover the adsorption sites of AChE would not be blocked by bovine serum albumin (BSA) which provides a good platform for the quantitative amperometric determination of AChE via the oxidation of the enzymatically generated H 2O 2 in the bienzyme system in the presence of acetylcholine. Hydrogen Peroxide 225-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 18363334-5 2008 Moreover the adsorption sites of AChE would not be blocked by bovine serum albumin (BSA) which provides a good platform for the quantitative amperometric determination of AChE via the oxidation of the enzymatically generated H 2O 2 in the bienzyme system in the presence of acetylcholine. Hydrogen Peroxide 225-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 18363334-5 2008 Moreover the adsorption sites of AChE would not be blocked by bovine serum albumin (BSA) which provides a good platform for the quantitative amperometric determination of AChE via the oxidation of the enzymatically generated H 2O 2 in the bienzyme system in the presence of acetylcholine. Acetylcholine 274-287 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 18363334-5 2008 Moreover the adsorption sites of AChE would not be blocked by bovine serum albumin (BSA) which provides a good platform for the quantitative amperometric determination of AChE via the oxidation of the enzymatically generated H 2O 2 in the bienzyme system in the presence of acetylcholine. Acetylcholine 274-287 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 18155915-0 2008 Facile synthesis of new carbon-11 labeled conformationally restricted rivastigmine analogues as potential PET agents for imaging AChE and BChE enzymes. Carbon-11 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 18155915-0 2008 Facile synthesis of new carbon-11 labeled conformationally restricted rivastigmine analogues as potential PET agents for imaging AChE and BChE enzymes. Rivastigmine 70-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 18155915-1 2008 Rivastigmine is a newer-generation inhibitor with a dual inhibitory action on both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes, and is used for the treatment of AChE- and BChE-related diseases such as brain Alzheimer"s disease and cardiovascular disease. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 18155915-1 2008 Rivastigmine is a newer-generation inhibitor with a dual inhibitory action on both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes, and is used for the treatment of AChE- and BChE-related diseases such as brain Alzheimer"s disease and cardiovascular disease. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 18155915-1 2008 Rivastigmine is a newer-generation inhibitor with a dual inhibitory action on both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes, and is used for the treatment of AChE- and BChE-related diseases such as brain Alzheimer"s disease and cardiovascular disease. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-191 18281016-0 2008 Effects of oximes on rate of decarbamylation of human red blood cell AChE measured with two different methods. Oximes 11-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 18281016-2 2008 The treatment options in soman poisoning are very limited due to rapid aging of the inhibited acetylcholinesterase (AChE), when the enzyme species is considered as irreversibly inhibited and resistant towards reactivation by oximes. Oximes 225-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 18281016-2 2008 The treatment options in soman poisoning are very limited due to rapid aging of the inhibited acetylcholinesterase (AChE), when the enzyme species is considered as irreversibly inhibited and resistant towards reactivation by oximes. Oximes 225-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 18281016-5 2008 One means of protecting against soman poisoning is the prophylactic use of certain reversible inhibitors (carbamates) of AChE. Carbamates 106-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 18281016-6 2008 The question whether there is a possibility of an interaction between pre-treating carbamates and oximes at AChE arises. Carbamates 83-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 18281016-6 2008 The question whether there is a possibility of an interaction between pre-treating carbamates and oximes at AChE arises. Oximes 98-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 18281016-7 2008 Therefore we studied the effects of the oximes obidoxime, HI 6 and MMB-4 on the rate of decarbamylation for physostigmine- and pyridostigmine-inhibited human erythrocyte AChE both in a dynamically working in vitro model and a static cuvette system. Physostigmine 108-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 18281016-7 2008 Therefore we studied the effects of the oximes obidoxime, HI 6 and MMB-4 on the rate of decarbamylation for physostigmine- and pyridostigmine-inhibited human erythrocyte AChE both in a dynamically working in vitro model and a static cuvette system. Pyridostigmine Bromide 127-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 18281016-10 2008 MMB-4 applied to pyridostigmine-inhibited AChE in the static system only showed no difference to the experiments made in absence of oxime. N,N'-monomethylenebis(pyridiniumaldoxime) 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 18281016-10 2008 MMB-4 applied to pyridostigmine-inhibited AChE in the static system only showed no difference to the experiments made in absence of oxime. Pyridostigmine Bromide 17-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 18070217-2 2008 * Donepezil hydrochloride exhibits selective inhibition of acetylcholinesterase (AChE) and is widely used for the treatment of AD. Donepezil 2-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 18070217-2 2008 * Donepezil hydrochloride exhibits selective inhibition of acetylcholinesterase (AChE) and is widely used for the treatment of AD. Donepezil 2-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 18070217-4 2008 * There is no method to measure the amount of binding of orally administered donepezil to AChE. Donepezil 77-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 18070217-7 2008 * This study provides methodology to measure the AChE binding occupancy of orally administered donepezil and provides a new surrogate marker for evaluation and prediction of response to donepezil treatment. Donepezil 95-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 18070217-7 2008 * This study provides methodology to measure the AChE binding occupancy of orally administered donepezil and provides a new surrogate marker for evaluation and prediction of response to donepezil treatment. Donepezil 186-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 18070217-8 2008 AIMS: The aims of this study were to visualize in vivo binding of donepezil to acetylcholinesterase (AChE) in the brain and to establish a method for measuring the amount of binding of orally administered donepezil. Donepezil 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 18070217-8 2008 AIMS: The aims of this study were to visualize in vivo binding of donepezil to acetylcholinesterase (AChE) in the brain and to establish a method for measuring the amount of binding of orally administered donepezil. Donepezil 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 18070217-12 2008 RESULTS: [(11)C]-donepezil-PET images demonstrated high densities of tracer distribution in AChE-rich brain regions such as the striatum, thalamus, and cerebellum. Donepezil 17-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 18070217-18 2008 Longitudinal evaluation by this technique enables determination of AChE binding occupancy of orally administered donepezil. Donepezil 113-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 18258603-2 2008 Our previous study demonstrated that silencing of the AChE gene blocked the interaction between cytochrome c and apoptotic protease-activating factor-1 (Apaf-1) in etoposide-induced apoptosis of HT-29 cells. Etoposide 164-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 18343905-0 2008 Structural insight into the inhibition of acetylcholinesterase by 2,3,4, 5-tetrahydro-1, 5-benzothiazepines. 2,3,4, 5-tetrahydro-1, 5-benzothiazepines 66-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 18343905-8 2008 The results indicated that substitution of halogen and methyl groups by hydrogen at aromatic ring of the benzothiazepine decreased the affinity of these molecules towards enzyme that may be due to the polar non-polar repulsions of these moieties with the amino acid residues in the active site of AChE. Halogens 43-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 297-301 18343905-8 2008 The results indicated that substitution of halogen and methyl groups by hydrogen at aromatic ring of the benzothiazepine decreased the affinity of these molecules towards enzyme that may be due to the polar non-polar repulsions of these moieties with the amino acid residues in the active site of AChE. Hydrogen 72-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 297-301 18343905-8 2008 The results indicated that substitution of halogen and methyl groups by hydrogen at aromatic ring of the benzothiazepine decreased the affinity of these molecules towards enzyme that may be due to the polar non-polar repulsions of these moieties with the amino acid residues in the active site of AChE. benzothiazepine 105-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 297-301 18343905-9 2008 The observed binding modes of benzothiazepines 1-3 in the active site of AChE explain the affinities of benzothiazepines and provide a rational basis for the structure-based drug design of benzothiazepines with improved pharmacological properties. benzothiazepines 30-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 18343905-9 2008 The observed binding modes of benzothiazepines 1-3 in the active site of AChE explain the affinities of benzothiazepines and provide a rational basis for the structure-based drug design of benzothiazepines with improved pharmacological properties. benzothiazepines 104-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 18343905-9 2008 The observed binding modes of benzothiazepines 1-3 in the active site of AChE explain the affinities of benzothiazepines and provide a rational basis for the structure-based drug design of benzothiazepines with improved pharmacological properties. benzothiazepines 104-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 18343906-1 2008 The anti-AChE activity of phosphoramidates has been noticed for many years. phosphoramidic acid 26-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 18207225-0 2008 The acetylcholinesterase inhibitor rivastigmine does not alter total choices for methamphetamine, but may reduce positive subjective effects, in a laboratory model of intravenous self-administration in human volunteers. Rivastigmine 35-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 18207225-2 2008 We conducted a double-blind, placebo-controlled, between groups investigation of the acetylcholinesterase (AChE) inhibitor rivastigmine in non-treatment-seeking volunteers who met criteria for methamphetamine abuse or dependence. Rivastigmine 123-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 18076960-0 2008 Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase. Chlorpyrifos 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 18076960-0 2008 Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 17-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 18076960-1 2008 A primary role of acetylcholinesterase (AChE) is regulation of cholinergic neurotransmission by hydrolysis of synaptic acetylcholine. Acetylcholine 18-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 18076960-3 2008 This raises the question of whether organophosphorus pesticides (OPs) that are known to selectively bind to and inactivate the enzymatic function of AChE also interfere with its morphogenic function to perturb axonogenesis. organophosphorus 36-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 18076960-3 2008 This raises the question of whether organophosphorus pesticides (OPs) that are known to selectively bind to and inactivate the enzymatic function of AChE also interfere with its morphogenic function to perturb axonogenesis. OPS 65-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 18332428-1 2008 Increasing evidence suggests excess illness in Persian Gulf War veterans (GWV) can be explained in part by exposure of GWV to organophosphate and carbamate acetylcholinesterase inhibitors (AChEis), including pyridostigmine bromide (PB), pesticides, and nerve agents. N1,N1-Dimethyl-4-[(Isopropylamino)Methyl]Aniline 74-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-176 18350169-11 2008 Consistently with the experimental observations and assembly models for other amyloid systems, we propose a model for AChE(586-599) assembly in which a steric-zipper formed through specific interactions (hydrophobic, electrostatic, cation-pi, SH-aromatic, metal chelation and polar-polar) would maintain the beta-sheets together. Metals 256-261 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 18465019-1 2008 A photoenolization reaction is shown to be the key reaction step in the preparation of substituted indan-1-ones as convenient precursors for the synthesis of donepezil, a well-known acetylcholinesterase inhibitor. indan-1-ones 99-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-202 18465019-1 2008 A photoenolization reaction is shown to be the key reaction step in the preparation of substituted indan-1-ones as convenient precursors for the synthesis of donepezil, a well-known acetylcholinesterase inhibitor. Donepezil 158-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-202 18370398-7 2008 Then, activity and toxicity of CP influenced by the encapsulated process of beta-CD were evaluated by an in vitro acetylcholinesterase (AChE) inhibition assay and an acute aquatic toxicity assay, respectively. betadex 76-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 18370398-7 2008 Then, activity and toxicity of CP influenced by the encapsulated process of beta-CD were evaluated by an in vitro acetylcholinesterase (AChE) inhibition assay and an acute aquatic toxicity assay, respectively. betadex 76-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 18304715-1 2008 The efficacy of oxime treatment in soman poisoning is limited due to rapid aging of inhibited acetylcholinesterase (AChE). Oximes 16-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 18304715-1 2008 The efficacy of oxime treatment in soman poisoning is limited due to rapid aging of inhibited acetylcholinesterase (AChE). Oximes 16-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 18304715-3 2008 Recently, by using a dynamically working in vitro model with real-time determination of membrane-bound AChE activity, we were able to demonstrate that pre-inhibition of human erythrocyte AChE with pyridostigmine or physostigmine resulted in a markedly higher residual AChE activity after inhibition by soman or paraoxon than in the absence of reversible inhibitors. Pyridostigmine Bromide 197-211 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 18304715-3 2008 Recently, by using a dynamically working in vitro model with real-time determination of membrane-bound AChE activity, we were able to demonstrate that pre-inhibition of human erythrocyte AChE with pyridostigmine or physostigmine resulted in a markedly higher residual AChE activity after inhibition by soman or paraoxon than in the absence of reversible inhibitors. Pyridostigmine Bromide 197-211 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 18304715-3 2008 Recently, by using a dynamically working in vitro model with real-time determination of membrane-bound AChE activity, we were able to demonstrate that pre-inhibition of human erythrocyte AChE with pyridostigmine or physostigmine resulted in a markedly higher residual AChE activity after inhibition by soman or paraoxon than in the absence of reversible inhibitors. Pyridostigmine Bromide 197-211 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 18304715-3 2008 Recently, by using a dynamically working in vitro model with real-time determination of membrane-bound AChE activity, we were able to demonstrate that pre-inhibition of human erythrocyte AChE with pyridostigmine or physostigmine resulted in a markedly higher residual AChE activity after inhibition by soman or paraoxon than in the absence of reversible inhibitors. Physostigmine 215-228 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 18304715-3 2008 Recently, by using a dynamically working in vitro model with real-time determination of membrane-bound AChE activity, we were able to demonstrate that pre-inhibition of human erythrocyte AChE with pyridostigmine or physostigmine resulted in a markedly higher residual AChE activity after inhibition by soman or paraoxon than in the absence of reversible inhibitors. Physostigmine 215-228 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 18304715-3 2008 Recently, by using a dynamically working in vitro model with real-time determination of membrane-bound AChE activity, we were able to demonstrate that pre-inhibition of human erythrocyte AChE with pyridostigmine or physostigmine resulted in a markedly higher residual AChE activity after inhibition by soman or paraoxon than in the absence of reversible inhibitors. Physostigmine 215-228 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 18304715-3 2008 Recently, by using a dynamically working in vitro model with real-time determination of membrane-bound AChE activity, we were able to demonstrate that pre-inhibition of human erythrocyte AChE with pyridostigmine or physostigmine resulted in a markedly higher residual AChE activity after inhibition by soman or paraoxon than in the absence of reversible inhibitors. Soman 302-307 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 18304715-3 2008 Recently, by using a dynamically working in vitro model with real-time determination of membrane-bound AChE activity, we were able to demonstrate that pre-inhibition of human erythrocyte AChE with pyridostigmine or physostigmine resulted in a markedly higher residual AChE activity after inhibition by soman or paraoxon than in the absence of reversible inhibitors. Soman 302-307 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 18304715-3 2008 Recently, by using a dynamically working in vitro model with real-time determination of membrane-bound AChE activity, we were able to demonstrate that pre-inhibition of human erythrocyte AChE with pyridostigmine or physostigmine resulted in a markedly higher residual AChE activity after inhibition by soman or paraoxon than in the absence of reversible inhibitors. Soman 302-307 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 18304715-3 2008 Recently, by using a dynamically working in vitro model with real-time determination of membrane-bound AChE activity, we were able to demonstrate that pre-inhibition of human erythrocyte AChE with pyridostigmine or physostigmine resulted in a markedly higher residual AChE activity after inhibition by soman or paraoxon than in the absence of reversible inhibitors. Paraoxon 311-319 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 18304715-3 2008 Recently, by using a dynamically working in vitro model with real-time determination of membrane-bound AChE activity, we were able to demonstrate that pre-inhibition of human erythrocyte AChE with pyridostigmine or physostigmine resulted in a markedly higher residual AChE activity after inhibition by soman or paraoxon than in the absence of reversible inhibitors. Paraoxon 311-319 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 18304715-3 2008 Recently, by using a dynamically working in vitro model with real-time determination of membrane-bound AChE activity, we were able to demonstrate that pre-inhibition of human erythrocyte AChE with pyridostigmine or physostigmine resulted in a markedly higher residual AChE activity after inhibition by soman or paraoxon than in the absence of reversible inhibitors. Paraoxon 311-319 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 18304715-4 2008 The purpose of the present study was to compare the effect of carbamate pre-treatment and soman challenge with human erythrocyte and muscle homogenate AChE. Carbamates 62-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 18304715-7 2008 Pre-inhibition of AChE with pyridostigmine or physostigmine resulted in a concentration-dependent increase in carbamylation, residual activity after soman inhibition and fraction of decarbamylation AChE after discontinuation of the inhibitors without differences between human erythrocyte and muscle AChE. Pyridostigmine Bromide 28-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 18304715-7 2008 Pre-inhibition of AChE with pyridostigmine or physostigmine resulted in a concentration-dependent increase in carbamylation, residual activity after soman inhibition and fraction of decarbamylation AChE after discontinuation of the inhibitors without differences between human erythrocyte and muscle AChE. Pyridostigmine Bromide 28-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-202 18304715-7 2008 Pre-inhibition of AChE with pyridostigmine or physostigmine resulted in a concentration-dependent increase in carbamylation, residual activity after soman inhibition and fraction of decarbamylation AChE after discontinuation of the inhibitors without differences between human erythrocyte and muscle AChE. Pyridostigmine Bromide 28-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-202 18304715-7 2008 Pre-inhibition of AChE with pyridostigmine or physostigmine resulted in a concentration-dependent increase in carbamylation, residual activity after soman inhibition and fraction of decarbamylation AChE after discontinuation of the inhibitors without differences between human erythrocyte and muscle AChE. Physostigmine 46-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 18304715-7 2008 Pre-inhibition of AChE with pyridostigmine or physostigmine resulted in a concentration-dependent increase in carbamylation, residual activity after soman inhibition and fraction of decarbamylation AChE after discontinuation of the inhibitors without differences between human erythrocyte and muscle AChE. Physostigmine 46-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-202 18304715-7 2008 Pre-inhibition of AChE with pyridostigmine or physostigmine resulted in a concentration-dependent increase in carbamylation, residual activity after soman inhibition and fraction of decarbamylation AChE after discontinuation of the inhibitors without differences between human erythrocyte and muscle AChE. Physostigmine 46-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-202 18343673-2 2008 Depending on the length of the alkylene spacer the amide hybrids are inhibitors of acetylcholinesterase (AChE) with inhibitory activities of 0.5-4.6microM and inhibitors of butyrylcholinesterase (BChE) with activities down to 5.7nM, therefore greatly exceeding the inhibitory activities of the parent quinazolinimines by factors of up to 1000. alkylene 31-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 18343673-2 2008 Depending on the length of the alkylene spacer the amide hybrids are inhibitors of acetylcholinesterase (AChE) with inhibitory activities of 0.5-4.6microM and inhibitors of butyrylcholinesterase (BChE) with activities down to 5.7nM, therefore greatly exceeding the inhibitory activities of the parent quinazolinimines by factors of up to 1000. alkylene 31-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 18343673-2 2008 Depending on the length of the alkylene spacer the amide hybrids are inhibitors of acetylcholinesterase (AChE) with inhibitory activities of 0.5-4.6microM and inhibitors of butyrylcholinesterase (BChE) with activities down to 5.7nM, therefore greatly exceeding the inhibitory activities of the parent quinazolinimines by factors of up to 1000. Amides 51-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 18343673-2 2008 Depending on the length of the alkylene spacer the amide hybrids are inhibitors of acetylcholinesterase (AChE) with inhibitory activities of 0.5-4.6microM and inhibitors of butyrylcholinesterase (BChE) with activities down to 5.7nM, therefore greatly exceeding the inhibitory activities of the parent quinazolinimines by factors of up to 1000. Amides 51-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 18343673-2 2008 Depending on the length of the alkylene spacer the amide hybrids are inhibitors of acetylcholinesterase (AChE) with inhibitory activities of 0.5-4.6microM and inhibitors of butyrylcholinesterase (BChE) with activities down to 5.7nM, therefore greatly exceeding the inhibitory activities of the parent quinazolinimines by factors of up to 1000. quinazolinimine 301-317 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 18343673-2 2008 Depending on the length of the alkylene spacer the amide hybrids are inhibitors of acetylcholinesterase (AChE) with inhibitory activities of 0.5-4.6microM and inhibitors of butyrylcholinesterase (BChE) with activities down to 5.7nM, therefore greatly exceeding the inhibitory activities of the parent quinazolinimines by factors of up to 1000. quinazolinimine 301-317 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 18333606-2 2008 Their acetylcholinesterase (AChE) inhibitory activities were more greatly influenced by the length of the alkylene chain than butyrylcholinesterase (BChE) inhibition. alkylene 106-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-26 18333606-2 2008 Their acetylcholinesterase (AChE) inhibitory activities were more greatly influenced by the length of the alkylene chain than butyrylcholinesterase (BChE) inhibition. alkylene 106-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 18333606-4 2008 Molecular docking elucidated that 5h simultaneously bound to the catalytic and peripheral sites in AChE via hydrophobic interactions with Trp86 and Trp286. 5h 34-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 18333606-6 2008 Furthermore, 5h and 5i markedly prevented the AChE-induced Abeta aggregation with IC 50 values of 16.6 and 5.8 microM, similar to that of propidium (IC 50 = 12.8 microM), which suggests promising disease-modifying agents for the treatment of AD patients. 5h 13-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 18333606-6 2008 Furthermore, 5h and 5i markedly prevented the AChE-induced Abeta aggregation with IC 50 values of 16.6 and 5.8 microM, similar to that of propidium (IC 50 = 12.8 microM), which suggests promising disease-modifying agents for the treatment of AD patients. carvone 20-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 18358865-5 2008 Immobilisation of enzymes including glucose oxidase, acetylcholinesterase and choline oxidase was achieved through their multi-contact electrostatic interaction with polyethyleneimine (PEI) which was electrodeposited on the surface of CoPc-doped electrodes in one step from ethanolic solution. aziridine 166-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 18358865-5 2008 Immobilisation of enzymes including glucose oxidase, acetylcholinesterase and choline oxidase was achieved through their multi-contact electrostatic interaction with polyethyleneimine (PEI) which was electrodeposited on the surface of CoPc-doped electrodes in one step from ethanolic solution. pei 185-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 18194150-1 2008 5-Hydroxytryptamine (5-HT4) receptor agonists increase gastrointestinal (GI) motility by enhancing enteric acetylcholine release which is then metabolized by acetylcholinesterase (AChE) to inactive metabolites. Acetylcholine 107-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 17990049-10 2008 A treatment with the AChE-inhibitor donepezil is accompanied with an increase of BDNF serum concentration in AD patients reaching the level of healthy controls. Donepezil 36-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 18436979-3 2008 One outcome of the present model is that the variable part of AChE activity is zero at the moment of acetylcholine (Ach) release and then increases. Acetylcholine 101-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 18436979-3 2008 One outcome of the present model is that the variable part of AChE activity is zero at the moment of acetylcholine (Ach) release and then increases. Acetylcholine 116-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 18287260-2 2008 The neurotransmitter acetylcholine is hydrolyzed in the synaptic clefts by 2 enzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Acetylcholine 21-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 18287260-2 2008 The neurotransmitter acetylcholine is hydrolyzed in the synaptic clefts by 2 enzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Acetylcholine 21-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 18191456-1 2008 Galantamine, an acetylcholinesterase inhibitor used to enhance memory in AD patients by acetylcholinesterase inhibition, has been tested for its protective properties on an in vitro model of H(2)O(2)-induced oxidative stress. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 18191456-1 2008 Galantamine, an acetylcholinesterase inhibitor used to enhance memory in AD patients by acetylcholinesterase inhibition, has been tested for its protective properties on an in vitro model of H(2)O(2)-induced oxidative stress. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 18191456-7 2008 Galantamine also concentration-dependently inhibited AChE activity (28-88%) in H(2)O(2)-SK-N-SH cells after 24h. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 17729290-4 2008 In this respect, molecular dynamics simulations and our recently developed metadynamics method were applied to study the entrance of the three cations in the gorge of hAChE, and their effect on the dynamical motion of a ligand (tetramethylammonium) from the bulk of the solvent into the deep narrow enzyme gorge. tetramethylammonium 228-247 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-172 18371787-6 2008 Under the optimal experimental conditions, the inhibition of malathion on AChE biosensor was proportional to its concentration in two ranges, from 0.001 to 0.1 microg mL(-1) and from 0.1 to 25 microg mL(-1), with detection limit of 0.001 microg mL(-1). Malathion 61-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 19029645-3 2008 Velnacrine maleate is a well-known AChE inhibitor which plays a competitive role by decreasing NO-mediated erythrocyte responses. velnacrine 0-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 18082383-7 2008 They might be explained by the interaction of either AChE or test compounds with the silica of the TLC plates, resulting in an altered affinity of the enzyme for the compounds. Silicon Dioxide 85-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 17977518-0 2008 Comparison of the oxime-induced reactivation of erythrocyte and muscle acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity. Oximes 18-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 17977518-1 2008 The purpose of these experiments was to compare oxime-induced reactivation rate constants of acetylcholinesterase from different human tissue sources inhibited by organophosphorus compounds. Oximes 48-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 17977518-1 2008 The purpose of these experiments was to compare oxime-induced reactivation rate constants of acetylcholinesterase from different human tissue sources inhibited by organophosphorus compounds. organophosphorus 163-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 17977518-8 2008 We detected no decrease of acetylcholinesterase activity within 2.5h and we reproducibly determined reactivation rate constants for reactivation with obidoxime (10 microM) or HI 6 (30 microM) of sarin-inhibited human muscle acetylcholinesterase (0.142+/-0.004 min(-1) and 0.166+/-0.008 min(-1), respectively). Obidoxime Chloride 150-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 224-244 17657601-3 2008 Huperzine A, a potent and reversible inhibitor of acetylcholinesterase that was initially isolated from a Chinese herb, has been found to improve cognitive deficits in a broad range of animal models and has been used for Alzheimer"s disease treatment in China. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 18205833-2 2008 Acetylcholinesterase is indispensable for terminating acetylcholine-mediated neurotransmission at cholinergic synapses. Acetylcholine 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 18341256-1 2008 Six AChE monooxime-monocarbamoyl reactivators with an (E)-but-2-ene linker were synthesized using modification of currently known synthetic pathways. monooxime 9-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 18341256-1 2008 Six AChE monooxime-monocarbamoyl reactivators with an (E)-but-2-ene linker were synthesized using modification of currently known synthetic pathways. monocarbamoyl 19-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 18341256-1 2008 Six AChE monooxime-monocarbamoyl reactivators with an (E)-but-2-ene linker were synthesized using modification of currently known synthetic pathways. 2-butene 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 18341256-4 2008 According to the results obtained, one reactivator seems to be promising against tabun-inhibited AChE and two reactivators against paraoxon-inhibited AChE. Paraoxon 131-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 17196712-0 2008 Inhibition of acetylcholinesterase in CSF versus brain assessed by 11C-PMP PET in AD patients treated with galantamine. 11c-pmp 67-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 17196712-0 2008 Inhibition of acetylcholinesterase in CSF versus brain assessed by 11C-PMP PET in AD patients treated with galantamine. Galantamine 107-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 17196712-1 2008 The relationship between acetylcholinesterase (AChE) activity in the CSF and brain of patients with Alzheimer"s disease (AD) was investigated in 18 mild AD patients following galantamine treatment. Galantamine 175-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 17196712-1 2008 The relationship between acetylcholinesterase (AChE) activity in the CSF and brain of patients with Alzheimer"s disease (AD) was investigated in 18 mild AD patients following galantamine treatment. Galantamine 175-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 18052268-0 2008 Continuum simulations of acetylcholine consumption by acetylcholinesterase: a Poisson-Nernst-Planck approach. Acetylcholine 25-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 18052268-1 2008 The Poisson-Nernst-Planck (PNP) equation provides a continuum description of electrostatic-driven diffusion and is used here to model the diffusion and reaction of acetylcholine (ACh) with acetylcholinesterase (AChE) enzymes. Acetylcholine 164-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-209 18052268-1 2008 The Poisson-Nernst-Planck (PNP) equation provides a continuum description of electrostatic-driven diffusion and is used here to model the diffusion and reaction of acetylcholine (ACh) with acetylcholinesterase (AChE) enzymes. Acetylcholine 164-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-215 18052268-1 2008 The Poisson-Nernst-Planck (PNP) equation provides a continuum description of electrostatic-driven diffusion and is used here to model the diffusion and reaction of acetylcholine (ACh) with acetylcholinesterase (AChE) enzymes. Acetylcholine 179-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-209 18052268-1 2008 The Poisson-Nernst-Planck (PNP) equation provides a continuum description of electrostatic-driven diffusion and is used here to model the diffusion and reaction of acetylcholine (ACh) with acetylcholinesterase (AChE) enzymes. Acetylcholine 179-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-215 18942695-0 2008 Nanoparticle-based electrochemical immunosensor for the detection of phosphorylated acetylcholinesterase: an exposure biomarker of organophosphate pesticides and nerve agents. Organophosphates 131-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 18942695-1 2008 A nanoparticle-based electrochemical immunosensor has been developed for the detection of phosphorylated acetylcholinesterase (AChE), which is a potential biomarker of exposure to organophosphate (OP) pesticides and chemical warfare nerve agents. Organophosphates 180-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 18942695-1 2008 A nanoparticle-based electrochemical immunosensor has been developed for the detection of phosphorylated acetylcholinesterase (AChE), which is a potential biomarker of exposure to organophosphate (OP) pesticides and chemical warfare nerve agents. Organophosphates 180-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 18194084-0 2008 The in vivo and in vitro effects of L-carnitine supplementation on the erythrocyte membrane acetylcholinesterase, Na+, K+-ATPase and Mg2+-ATPase activities in basketball players. Carnitine 36-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 18194084-7 2008 In vitro incubation of the modulated AChE and Na+, K+-ATPase with L-C (25 microM) from group B and group D resulted in a non-significant reduction of the enzymes in group B and complete restoration of their activities in group D. CONCLUSIONS: The increase of AChE and Na+, K+-ATPase activities may be due to the elevation of catecholamines in group B. Catecholamines 325-339 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 18612832-4 2008 Several AChE inhibitors dose-dependently suppressed colony formation of HTB-38 cells in soft agar. Agar 93-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-12 18503146-5 2008 Our results showed that erythrocyte deformability was significantly (i) decreased by inhibition of PKC, in absence and presence of AChE inhibitor velnacrine (ii) increased with PMA in absence and presence of ACh and (iii) decreased in presence of calpeptin in absence and presence of either chelerythrine or PMA. velnacrine 146-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 19029635-8 2008 Upon intracellular thiol stimulation, the presence of AChE effectors (either acetylcholine or velnacrine) decreases erythrocyte aggregation and elongation indexes. Sulfhydryl Compounds 19-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 19029635-8 2008 Upon intracellular thiol stimulation, the presence of AChE effectors (either acetylcholine or velnacrine) decreases erythrocyte aggregation and elongation indexes. Acetylcholine 77-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 19029635-8 2008 Upon intracellular thiol stimulation, the presence of AChE effectors (either acetylcholine or velnacrine) decreases erythrocyte aggregation and elongation indexes. velnacrine 94-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 19029635-10 2008 However, upon acetylcholinesterase modulation by its substrate or inhibitor, changes on the hemorheological parameters are triggered by DTT. Dithiothreitol 136-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 18371683-0 2008 An optical fiber biosensor for chlorpyrifos using a single sol-gel film containing acetylcholinesterase and bromothymol blue. Chlorpyrifos 31-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 18371683-1 2008 An optical fiber biosensor consisting of acetylcholinesterase (AChE) and bromothymol blue (BTB) doped sol-gel film was employed to detect organophosphate pesticide chlorpyrifos. Organophosphates 138-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 18371683-1 2008 An optical fiber biosensor consisting of acetylcholinesterase (AChE) and bromothymol blue (BTB) doped sol-gel film was employed to detect organophosphate pesticide chlorpyrifos. Organophosphates 138-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 18371683-1 2008 An optical fiber biosensor consisting of acetylcholinesterase (AChE) and bromothymol blue (BTB) doped sol-gel film was employed to detect organophosphate pesticide chlorpyrifos. Chlorpyrifos 164-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 18371683-1 2008 An optical fiber biosensor consisting of acetylcholinesterase (AChE) and bromothymol blue (BTB) doped sol-gel film was employed to detect organophosphate pesticide chlorpyrifos. Chlorpyrifos 164-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 18371683-6 2008 In the presence of a constant AChE, a color change of the BTB and the measured reflected signal at wavelength 622nm could be related to the pesticide concentration in the sample solutions. Bromthymol Blue 58-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 18371683-9 2008 A linear calibration curve of chlorpyrifos against the percentage inhibition of AChE was obtained from 0.05 to 2.0mg/L of chlorpyrifos (18-80% inhibition, R(2)=0.9869, n=6). Chlorpyrifos 30-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 18371683-9 2008 A linear calibration curve of chlorpyrifos against the percentage inhibition of AChE was obtained from 0.05 to 2.0mg/L of chlorpyrifos (18-80% inhibition, R(2)=0.9869, n=6). Chlorpyrifos 122-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 17980356-0 2008 alpha,beta-Dehydrophenylalanine choline esters, a new class of reversible inhibitors of human acetylcholinesterase and butyrylcholinesterase. alpha,beta-dehydrophenylalanine choline esters 0-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-140 17980356-3 2008 The potency of the amino acid ester derivatives was tested by measuring K(i) values for inhibition of human red cell acetylcholinesterase and human plasma butyrylcholinesterase. amino acid ester 19-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 17986678-3 2008 The current study was designed to examine the efficacy and safety of galantamine, an acetylcholinesterase inhibitor that also acts as an allosteric modulator at the alpha(4)beta(2) and alpha(7) nicotinic receptors, for the treatment of these impairments. Galantamine 69-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 17998161-0 2008 Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds. coumarin 22-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-49 17712622-0 2008 PMS777, a bis-interacting ligand for PAF receptor antagonism and AChE inhibition, attenuates PAF-induced neurocytotoxicity in SH-SY5Y cells. PMS 777 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 19029645-9 2008 As to NO/NOx quantification, in the presence of PTKi we reported higher levels with velnacrine-AChE, as opposed to acetylcholine-AChE. velnacrine 84-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 19029645-12 2008 CONCLUSION: Changes on human erythrocyte NOx mobilization and metabolic fluxes occur under influence of non-neuronal ACh/AChE, in turn dependent on the degree of band 3-phosphorylation. Acetylcholine 117-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 18393843-10 2008 Oximes, by reactivating acetylcholinesterase, are important adjunct therapeutics in organophosphate poisoning. Oximes 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 18393843-10 2008 Oximes, by reactivating acetylcholinesterase, are important adjunct therapeutics in organophosphate poisoning. Organophosphates 84-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 18473814-4 2008 AD and other forms of dementia could be treated by the use of agents which restore the level of acetylcholine through inhibition of both two major forms of cholinesterase: acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Acetylcholine 96-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-192 18473814-4 2008 AD and other forms of dementia could be treated by the use of agents which restore the level of acetylcholine through inhibition of both two major forms of cholinesterase: acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Acetylcholine 96-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 194-198 18161504-1 2008 Class of monoquaternary pyridinium oximes was in vitro tested as potential reactivators of acetylcholinesterase (AChE; EC 3.1.1.7) inhibited by nerve agent sarin. monoquaternary 9-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 18161504-1 2008 Class of monoquaternary pyridinium oximes was in vitro tested as potential reactivators of acetylcholinesterase (AChE; EC 3.1.1.7) inhibited by nerve agent sarin. monoquaternary 9-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 18161504-1 2008 Class of monoquaternary pyridinium oximes was in vitro tested as potential reactivators of acetylcholinesterase (AChE; EC 3.1.1.7) inhibited by nerve agent sarin. pyridinium oximes 24-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 18161504-1 2008 Class of monoquaternary pyridinium oximes was in vitro tested as potential reactivators of acetylcholinesterase (AChE; EC 3.1.1.7) inhibited by nerve agent sarin. pyridinium oximes 24-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 23480140-3 2008 OBJECTIVE: This article reviews the development of novel classes of high affinity AChE inhibitors following a design strategy based on molecular hybridization by stepwise incorporation of different fragments of the known AChE inhibitors (-)-huperzine A and tacrine. huperzine A 237-252 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 23480140-3 2008 OBJECTIVE: This article reviews the development of novel classes of high affinity AChE inhibitors following a design strategy based on molecular hybridization by stepwise incorporation of different fragments of the known AChE inhibitors (-)-huperzine A and tacrine. huperzine A 237-252 acetylcholinesterase (Cartwright blood group) Homo sapiens 221-225 23480140-3 2008 OBJECTIVE: This article reviews the development of novel classes of high affinity AChE inhibitors following a design strategy based on molecular hybridization by stepwise incorporation of different fragments of the known AChE inhibitors (-)-huperzine A and tacrine. Tacrine 257-264 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 23480140-3 2008 OBJECTIVE: This article reviews the development of novel classes of high affinity AChE inhibitors following a design strategy based on molecular hybridization by stepwise incorporation of different fragments of the known AChE inhibitors (-)-huperzine A and tacrine. Tacrine 257-264 acetylcholinesterase (Cartwright blood group) Homo sapiens 221-225 23480140-5 2008 RESULTS/CONCLUSION: Three novel classes of AChE inhibitors of increasing structural complexity and affinity have been developed, namely huprines, 13-amidohuprines and huprine-tacrine heterodimers. huprines 136-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 23480140-5 2008 RESULTS/CONCLUSION: Three novel classes of AChE inhibitors of increasing structural complexity and affinity have been developed, namely huprines, 13-amidohuprines and huprine-tacrine heterodimers. 13-amidohuprines 146-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 17945434-2 2007 We investigated the effects of the acetylcholinesterase inhibitor, huperzine A (Hup A), on APP processing and Abeta generation in human neuroblastoma SK-N-SH cells overexpressing wild-type human APP695. huperzine A 67-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 17986217-2 2008 The enzyme is involved in the terminal breakdown of the neurotransmitter acetylcholine, but non-enzymatic roles have also been described for the entire AChE molecule and its isolated C-terminal sequences. Acetylcholine 73-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 17384975-0 2008 Photodynamic inhibition of acetylcholinesterase after two-photon excitation of copper tetrasulfophthalocyanine. copper tetrasulfophthalocyanine 79-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 17384975-1 2008 Sequential two-photon (2-gamma) activated copper tetrasulfophthalocyanine (CuPcS(4)) was shown capable of inactivating acetylcholinesterase (ACE). copper tetrasulfophthalocyanine 42-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 17384975-1 2008 Sequential two-photon (2-gamma) activated copper tetrasulfophthalocyanine (CuPcS(4)) was shown capable of inactivating acetylcholinesterase (ACE). copper tetrasulfophthalocyanine 42-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-144 17384975-1 2008 Sequential two-photon (2-gamma) activated copper tetrasulfophthalocyanine (CuPcS(4)) was shown capable of inactivating acetylcholinesterase (ACE). cupcs 75-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 17384975-1 2008 Sequential two-photon (2-gamma) activated copper tetrasulfophthalocyanine (CuPcS(4)) was shown capable of inactivating acetylcholinesterase (ACE). cupcs 75-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-144 17384975-5 2008 We conclude that the photoinactivation of ACE with sequential 2-gamma irradiation involves reactive oxygen species produced by the interaction of the upper excited T(n) state of CuPcS(4) with molecular oxygen. Reactive Oxygen Species 91-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-45 17384975-5 2008 We conclude that the photoinactivation of ACE with sequential 2-gamma irradiation involves reactive oxygen species produced by the interaction of the upper excited T(n) state of CuPcS(4) with molecular oxygen. Oxygen 100-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-45 17587508-4 2008 By nature, the precise ACh levels and responses from receptors must be controlled and regulated by its degrading enzymes, the cholinesterases (ChEs), namely, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Acetylcholine 23-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-178 20020898-1 2008 ABSTRACT This study describes the evaluation of the in vitro ability of two acetylcholinesterase (EC 3.1.1.7) reactivators, HI-6 and HLo-7, very promising at present, to reactivate human brain cholinesterases inhibited by the nerve agent cyclosarin. asoxime chloride 124-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 20020898-1 2008 ABSTRACT This study describes the evaluation of the in vitro ability of two acetylcholinesterase (EC 3.1.1.7) reactivators, HI-6 and HLo-7, very promising at present, to reactivate human brain cholinesterases inhibited by the nerve agent cyclosarin. cyclohexyl methylphosphonofluoridate 238-248 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 18047264-3 2007 The multifunctional compounds show activity against human AChE, are able to inhibit the AChE-induced amyloid-beta aggregation, and chelate metals, such as iron and copper. Iron 155-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 18047264-3 2007 The multifunctional compounds show activity against human AChE, are able to inhibit the AChE-induced amyloid-beta aggregation, and chelate metals, such as iron and copper. Copper 164-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 17932038-0 2007 Controlled concealment of exposed clearance and immunogenic domains by site-specific polyethylene glycol attachment to acetylcholinesterase hypolysine mutants. Polyethylene Glycols 85-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 18031622-0 2007 Molecular docking and 3D-QSAR studies of 2-substituted 1-indanone derivatives as acetylcholinesterase inhibitors. 2-substituted 1-indanone 41-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 18031622-1 2007 AIM: To explore the binding mode of 2-substituted 1-indanone derivatives with acetylcholinesterase (AChE) and provide hints for the future design of new derivatives with higher potency and specificity. 2-substituted 1-indanone 36-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 18031622-1 2007 AIM: To explore the binding mode of 2-substituted 1-indanone derivatives with acetylcholinesterase (AChE) and provide hints for the future design of new derivatives with higher potency and specificity. 2-substituted 1-indanone 36-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 17852161-6 2007 CASE REPORT AND RESULTS: A 29-year-old male ingested 50 to 100mL (12 to 24 g) of methyl parathion causing delayed and prolonged suppression of acetylcholinesterase but almost no clinical effects. Methyl Parathion 81-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 18220560-1 2007 Understanding the mechanism of action of organophosphates (OP)/nerve agents -- irreversible acetylcholinesterase (AChE, EC 3.1.1.7) inhibition at the cholinergic synapses followed by metabolic dysbalance of the organism -- two therapeutic principles for antidotal treatment are derived. Organophosphates 41-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 18220560-2 2007 The main drugs are anticholinergics that antagonize the effects of accumulated acetylcholine at the cholinergic synapses and cholinesterase reactivators (oximes) reactivating inhibited AChE. Oximes 154-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 185-189 18220560-9 2007 An universality of oximes able to reactivate AChE inhibited by all OP is questioned and therefore, needs of development of new oximes is underlined. Oximes 19-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 18042006-3 2007 The acetylcholinesterase inhibitors used to treat AD patients at present are donepezil, rivastigmine and galantamine. Donepezil 77-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 18042006-3 2007 The acetylcholinesterase inhibitors used to treat AD patients at present are donepezil, rivastigmine and galantamine. Rivastigmine 88-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 18042006-3 2007 The acetylcholinesterase inhibitors used to treat AD patients at present are donepezil, rivastigmine and galantamine. Galantamine 105-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 18042006-4 2007 This review summarises the current state of the art concerning the pharmacology of galantamine, focusing on the most important details of its possibilities as an acetylcholinesterase inhibitor, an allosteric potentiator of neuronal nicotinic receptors for acetylcholine, a modulator of neurotransmitter release, and an agent causing neuroprotection through an antiapoptotic action. Galantamine 83-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-182 18049927-1 2007 Organophosphate pesticides have been classically described as inhibitors of acetylcholinesterase (AChE) activity in insects and invertebrates. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 17932038-3 2007 Series of multiple Lys-Ala mutants of human acetylcholinesterase were prepared allowing the generation of homogenous and well defined polyethylene-glycol conjugated AChEs with either one, two, three, four, or five appended polyethylene glycol (PEG) moieties/molecule. L-lysyl-L-alanine 19-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 17932038-3 2007 Series of multiple Lys-Ala mutants of human acetylcholinesterase were prepared allowing the generation of homogenous and well defined polyethylene-glycol conjugated AChEs with either one, two, three, four, or five appended polyethylene glycol (PEG) moieties/molecule. Polyethylene Glycols 134-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 17932038-3 2007 Series of multiple Lys-Ala mutants of human acetylcholinesterase were prepared allowing the generation of homogenous and well defined polyethylene-glycol conjugated AChEs with either one, two, three, four, or five appended polyethylene glycol (PEG) moieties/molecule. Polyethylene Glycols 223-242 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 17932038-3 2007 Series of multiple Lys-Ala mutants of human acetylcholinesterase were prepared allowing the generation of homogenous and well defined polyethylene-glycol conjugated AChEs with either one, two, three, four, or five appended polyethylene glycol (PEG) moieties/molecule. Polyethylene Glycols 244-247 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 17932038-5 2007 Hypolysine acetylcholinesterases (AChEs) carrying the same number of PEGs, and therefore with identical masses, allowed us to demonstrate that circulatory longevity correlates with the predicted extent of concealment of the AChE surface. Polyethylene Glycols 69-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 17932038-6 2007 Furthermore, circulatory profiles of high number and low number PEG-AChEs differing in their sialic acid contents demonstrate a direct relationship between PEG loading and the effective seclusion of AChE from the hepatic asialoglycoprotein receptor clearance system. Polyethylene Glycols 64-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 17932038-6 2007 Furthermore, circulatory profiles of high number and low number PEG-AChEs differing in their sialic acid contents demonstrate a direct relationship between PEG loading and the effective seclusion of AChE from the hepatic asialoglycoprotein receptor clearance system. N-Acetylneuraminic Acid 93-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 17932038-6 2007 Furthermore, circulatory profiles of high number and low number PEG-AChEs differing in their sialic acid contents demonstrate a direct relationship between PEG loading and the effective seclusion of AChE from the hepatic asialoglycoprotein receptor clearance system. Polyethylene Glycols 156-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 17932038-7 2007 Finally, an inverse relationship is found between the extent of PEG loading and the ability of the human acetylcholinesterase to elicit specific anti-HuAChE antibodies. Polyethylene Glycols 64-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 17639556-4 2007 Hydroalcohol extracts of six herbs, Andrographis paniculata, Centella asiatica, Evalvulus alsinoides, Nardostachys jatamansi, Nelumbo nucifera, Myristica fragrans used in Indian systems of medicine, were tested for in vitro acetylcholinesterase inhibitory activity based on Ellman"s method in 96-well microplates using AChE obtained from bovine erythrocytes. hydroalcohol 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 319-323 17639556-5 2007 The results showed that the hydroalcohol extract from Centella asiatica, Nardostachys jatamansi, Myristica fragrans, Evalvulus alsinoides inhibited 50% of AChE activity at concentrations of 100-150 microg/mL. hydroalcohol 28-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 17914643-2 2007 A screening model of AChE inhibitor was used to evaluate the inhibition of a series of phenyl pentenone derivatives. phenyl pentenone 87-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 17897769-2 2007 It is characterized by low-to-moderate acute mammalian toxicity; similarly to the other OPT pesticides, its mode of action is mediated by the inhibition of acetylcholinesterase (AChE), exerted by its toxic metabolite dimethoate-oxon or omethoate (OME), which is also used as a direct acting pesticide. dimethoxon 217-232 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-176 17897769-2 2007 It is characterized by low-to-moderate acute mammalian toxicity; similarly to the other OPT pesticides, its mode of action is mediated by the inhibition of acetylcholinesterase (AChE), exerted by its toxic metabolite dimethoate-oxon or omethoate (OME), which is also used as a direct acting pesticide. dimethoxon 217-232 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-182 17897769-2 2007 It is characterized by low-to-moderate acute mammalian toxicity; similarly to the other OPT pesticides, its mode of action is mediated by the inhibition of acetylcholinesterase (AChE), exerted by its toxic metabolite dimethoate-oxon or omethoate (OME), which is also used as a direct acting pesticide. dimethoxon 236-245 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-176 17897769-2 2007 It is characterized by low-to-moderate acute mammalian toxicity; similarly to the other OPT pesticides, its mode of action is mediated by the inhibition of acetylcholinesterase (AChE), exerted by its toxic metabolite dimethoate-oxon or omethoate (OME), which is also used as a direct acting pesticide. dimethoxon 236-245 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-182 17897769-2 2007 It is characterized by low-to-moderate acute mammalian toxicity; similarly to the other OPT pesticides, its mode of action is mediated by the inhibition of acetylcholinesterase (AChE), exerted by its toxic metabolite dimethoate-oxon or omethoate (OME), which is also used as a direct acting pesticide. dimethoxon 247-250 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-176 17897769-2 2007 It is characterized by low-to-moderate acute mammalian toxicity; similarly to the other OPT pesticides, its mode of action is mediated by the inhibition of acetylcholinesterase (AChE), exerted by its toxic metabolite dimethoate-oxon or omethoate (OME), which is also used as a direct acting pesticide. dimethoxon 247-250 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-182 17897769-3 2007 Human hepatic DIM bioactivation to the toxic metabolite OME has been characterized by using c-DNA expressed human CYPs and human liver microsomes (HLM) also in the presence of CYP-specific chemical inhibitors, with a method based on AChE inhibition. dimethoxon 56-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-237 17714697-1 2007 The potential of the most active pyridinium-4-aldoximes, such as obidoxime and trimedoxime, to reactivate phosphorylated acetylcholinesterase is not fully exploited because of inevitable formation of phosphoryloximes (POXs) with extremely high anticholinesterase activity. Obidoxime Chloride 65-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 17714697-1 2007 The potential of the most active pyridinium-4-aldoximes, such as obidoxime and trimedoxime, to reactivate phosphorylated acetylcholinesterase is not fully exploited because of inevitable formation of phosphoryloximes (POXs) with extremely high anticholinesterase activity. Trimedoxime 79-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 17714697-4 2007 Their inhibition rate of acetylcholinesterase from human red cell membranes was by a factor of 2250, 480 and 600 higher than that observed with paraoxon-methyl, paraoxon-ethyl, and diisopropyl phosphorofluoridate, respectively. methylparaoxon 144-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 17714697-4 2007 Their inhibition rate of acetylcholinesterase from human red cell membranes was by a factor of 2250, 480 and 600 higher than that observed with paraoxon-methyl, paraoxon-ethyl, and diisopropyl phosphorofluoridate, respectively. paraoxon-ethyl, and diisopropyl phosphorofluoridate 161-212 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 17764957-0 2007 Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase. monooxime 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 17764957-0 2007 Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase. monooxime 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 17764957-0 2007 Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase. 2-butene 52-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 17764957-0 2007 Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase. 2-butene 52-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 17764957-0 2007 Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase. Paraoxon 117-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 17764957-0 2007 Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase. Paraoxon 117-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 17764957-1 2007 Acetylcholinesterase reactivators are crucial antidotes for the treatment of organophosphate intoxication. Organophosphates 77-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 17764957-2 2007 Fifteen new monooxime reactivators of acetylcholinesterase with a (E)-but-2-ene linker were developed in an effort to extend the properties of K-oxime (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203). monooxime 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 17764957-2 2007 Fifteen new monooxime reactivators of acetylcholinesterase with a (E)-but-2-ene linker were developed in an effort to extend the properties of K-oxime (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203). 2-butene 66-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 17764957-2 2007 Fifteen new monooxime reactivators of acetylcholinesterase with a (E)-but-2-ene linker were developed in an effort to extend the properties of K-oxime (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203). k-oxime 143-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 17764957-2 2007 Fifteen new monooxime reactivators of acetylcholinesterase with a (E)-but-2-ene linker were developed in an effort to extend the properties of K-oxime (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203). BDBM50333783 151-235 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 17764957-2 2007 Fifteen new monooxime reactivators of acetylcholinesterase with a (E)-but-2-ene linker were developed in an effort to extend the properties of K-oxime (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203). 2-Methyl-5-phenylbenzothiazole 237-241 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 17764957-3 2007 The known reactivators (pralidoxime, HI-6, obidoxime, K075, K203) and the new compounds were tested in vitro on a model of tabun- and paraoxon-inhibited AChE. Paraoxon 134-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 17370251-0 2007 Reactivation of organophosphate-inhibited human AChE by combinations of obidoxime and HI 6 in vitro. Organophosphates 16-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 17370251-0 2007 Reactivation of organophosphate-inhibited human AChE by combinations of obidoxime and HI 6 in vitro. Obidoxime Chloride 72-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 17370251-0 2007 Reactivation of organophosphate-inhibited human AChE by combinations of obidoxime and HI 6 in vitro. asoxime chloride 86-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 17370251-2 2007 The standard treatment with atropine and acetylcholinesterase (AChE) reactivators (oximes) is considered to be ineffective with certain nerve agents due to low oxime efficacy. Oximes 83-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 17370251-2 2007 The standard treatment with atropine and acetylcholinesterase (AChE) reactivators (oximes) is considered to be ineffective with certain nerve agents due to low oxime efficacy. Oximes 83-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 17370251-2 2007 The standard treatment with atropine and acetylcholinesterase (AChE) reactivators (oximes) is considered to be ineffective with certain nerve agents due to low oxime efficacy. Oximes 83-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 17370251-2 2007 The standard treatment with atropine and acetylcholinesterase (AChE) reactivators (oximes) is considered to be ineffective with certain nerve agents due to low oxime efficacy. Oximes 83-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 17370251-4 2007 The prospective oxime HI 6 is a weak reactivator of tabun- and pesticide-inhibited AChE, while the established oxime obidoxime mainly lacks efficacy with cyclosarin-inhibited enzyme. Oximes 16-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 17370251-5 2007 In order to investigate the feasibility of combining obidoxime and HI 6, human AChE inhibited by sarin, cyclosarin, VX, tabun and paraoxon was reactivated by these oximes either alone or in combination. Obidoxime Chloride 53-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 17370251-5 2007 In order to investigate the feasibility of combining obidoxime and HI 6, human AChE inhibited by sarin, cyclosarin, VX, tabun and paraoxon was reactivated by these oximes either alone or in combination. asoxime chloride 67-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 17370251-5 2007 In order to investigate the feasibility of combining obidoxime and HI 6, human AChE inhibited by sarin, cyclosarin, VX, tabun and paraoxon was reactivated by these oximes either alone or in combination. cyclohexyl methylphosphonofluoridate 104-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 17370251-5 2007 In order to investigate the feasibility of combining obidoxime and HI 6, human AChE inhibited by sarin, cyclosarin, VX, tabun and paraoxon was reactivated by these oximes either alone or in combination. tabun 120-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 17370251-5 2007 In order to investigate the feasibility of combining obidoxime and HI 6, human AChE inhibited by sarin, cyclosarin, VX, tabun and paraoxon was reactivated by these oximes either alone or in combination. Paraoxon 130-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 17902635-0 2007 New potent acetylcholinesterase inhibitors in the tetracyclic triterpene series. Triterpenes 62-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 17924614-0 2007 Design of a potent reactivator of tabun-inhibited acetylcholinesterase--synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203). tabun 34-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 17924614-0 2007 Design of a potent reactivator of tabun-inhibited acetylcholinesterase--synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203). BDBM50333783 100-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 17924614-0 2007 Design of a potent reactivator of tabun-inhibited acetylcholinesterase--synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203). 2-Methyl-5-phenylbenzothiazole 186-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 17924614-1 2007 Acetylcholinesterase reactivators are crucial antidotes for the treatment of organophosphate intoxication. Organophosphates 77-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 18049927-4 2007 This enzyme is more sensitive than AChE to some organophosphates (OP), including dichlorvos, which is the parent compound for metrifonate, a therapeutic agent used in the treatment of cognitive impairment associated to Alzheimer"s disease. Dichlorvos 81-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 18049445-3 2007 As a result of this increase in the activities of enzymes acetylcholinesterase and butyrylcholinesterase, the plasma and tissue levels of acetylcholine (ACh) will be low. Acetylcholine 153-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 17944454-1 2007 Gallamine and tacrine are allosteric antagonists at muscarinic M2 acetylcholine receptors and inhibitors of acetylcholinesterase. Gallamine Triethiodide 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 17944454-1 2007 Gallamine and tacrine are allosteric antagonists at muscarinic M2 acetylcholine receptors and inhibitors of acetylcholinesterase. Tacrine 14-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 17944454-2 2007 At both acetylcholine-binding proteins, gallamine and tacrine are known to occupy two different binding sites: in M2 receptors within the allosteric binding area and in acetylcholinesterase at its catalytic and its peripheral site. Gallamine Triethiodide 40-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-189 17944454-2 2007 At both acetylcholine-binding proteins, gallamine and tacrine are known to occupy two different binding sites: in M2 receptors within the allosteric binding area and in acetylcholinesterase at its catalytic and its peripheral site. Tacrine 54-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-189 18463730-5 2007 The kinetics of acetylcholinesterase inhibition by poly-APS in vitro is complex and comprises several successive phases ending in irreversible inhibition of the enzyme. poly-aps 51-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 18463730-8 2007 Monitoring of the basic vital functions and histopathological analysis showed that the effects directly ascribable to acetylcholinesterase inhibition are only observed after application of lower concentrations of poly-APS. poly-aps 213-221 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 18007027-0 2007 Use of a "caged" analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography. Choline 50-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 18007027-3 2007 Here, a kinetic crystallography strategy aimed at structurally addressing the issue of product traffic in acetylcholinesterase is presented, in which UV-laser-induced cleavage of a photolabile precursor of the enzymatic product analogue arsenocholine, "caged" arsenocholine, is performed in a temperature-controlled X-ray crystallography regime. arsenocholine 237-250 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 18007027-3 2007 Here, a kinetic crystallography strategy aimed at structurally addressing the issue of product traffic in acetylcholinesterase is presented, in which UV-laser-induced cleavage of a photolabile precursor of the enzymatic product analogue arsenocholine, "caged" arsenocholine, is performed in a temperature-controlled X-ray crystallography regime. arsenocholine 260-273 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 18007027-4 2007 The "caged" arsenocholine was shown to bind at both the active and peripheral sites of acetylcholinesterase. arsenocholine 12-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 18049927-1 2007 Organophosphate pesticides have been classically described as inhibitors of acetylcholinesterase (AChE) activity in insects and invertebrates. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 18049927-4 2007 This enzyme is more sensitive than AChE to some organophosphates (OP), including dichlorvos, which is the parent compound for metrifonate, a therapeutic agent used in the treatment of cognitive impairment associated to Alzheimer"s disease. Organophosphates 48-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 18049927-4 2007 This enzyme is more sensitive than AChE to some organophosphates (OP), including dichlorvos, which is the parent compound for metrifonate, a therapeutic agent used in the treatment of cognitive impairment associated to Alzheimer"s disease. Trichlorfon 126-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 18210807-1 2007 Carbon-11 labeled N-methylpiperidin-4-yl acetate ([11C]MP4A) and carbon-11 labeled N-methylpiperidin-4-yl propionate ([11C]MP4P) are acetylcholine analogues and have been successfully used for measurement of brain acetylcholinesterase (AChE) activity in vivo in humans. Carbon-11 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-234 18210807-1 2007 Carbon-11 labeled N-methylpiperidin-4-yl acetate ([11C]MP4A) and carbon-11 labeled N-methylpiperidin-4-yl propionate ([11C]MP4P) are acetylcholine analogues and have been successfully used for measurement of brain acetylcholinesterase (AChE) activity in vivo in humans. Carbon-11 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 236-240 18210807-1 2007 Carbon-11 labeled N-methylpiperidin-4-yl acetate ([11C]MP4A) and carbon-11 labeled N-methylpiperidin-4-yl propionate ([11C]MP4P) are acetylcholine analogues and have been successfully used for measurement of brain acetylcholinesterase (AChE) activity in vivo in humans. N-methylpiperidin-4-yl propionate 83-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-234 18210807-1 2007 Carbon-11 labeled N-methylpiperidin-4-yl acetate ([11C]MP4A) and carbon-11 labeled N-methylpiperidin-4-yl propionate ([11C]MP4P) are acetylcholine analogues and have been successfully used for measurement of brain acetylcholinesterase (AChE) activity in vivo in humans. N-methylpiperidin-4-yl propionate 83-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 236-240 18210807-1 2007 Carbon-11 labeled N-methylpiperidin-4-yl acetate ([11C]MP4A) and carbon-11 labeled N-methylpiperidin-4-yl propionate ([11C]MP4P) are acetylcholine analogues and have been successfully used for measurement of brain acetylcholinesterase (AChE) activity in vivo in humans. Acetylcholine 133-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-234 18210807-1 2007 Carbon-11 labeled N-methylpiperidin-4-yl acetate ([11C]MP4A) and carbon-11 labeled N-methylpiperidin-4-yl propionate ([11C]MP4P) are acetylcholine analogues and have been successfully used for measurement of brain acetylcholinesterase (AChE) activity in vivo in humans. Acetylcholine 133-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 236-240 17698511-1 2007 Some organophosphorus compounds are toxic because they inhibit acetylcholinesterase (AChE) by phosphylation of the active site serine, forming a stable conjugate: Ser-O-P(O)-(Y)-(XR) (where X can be O, N, or S and Y can be methyl, OR, or SR). organophosphorus 5-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 17698511-1 2007 Some organophosphorus compounds are toxic because they inhibit acetylcholinesterase (AChE) by phosphylation of the active site serine, forming a stable conjugate: Ser-O-P(O)-(Y)-(XR) (where X can be O, N, or S and Y can be methyl, OR, or SR). organophosphorus 5-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 17698511-1 2007 Some organophosphorus compounds are toxic because they inhibit acetylcholinesterase (AChE) by phosphylation of the active site serine, forming a stable conjugate: Ser-O-P(O)-(Y)-(XR) (where X can be O, N, or S and Y can be methyl, OR, or SR). Serine 127-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 17698511-1 2007 Some organophosphorus compounds are toxic because they inhibit acetylcholinesterase (AChE) by phosphylation of the active site serine, forming a stable conjugate: Ser-O-P(O)-(Y)-(XR) (where X can be O, N, or S and Y can be methyl, OR, or SR). Serine 127-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 17698511-1 2007 Some organophosphorus compounds are toxic because they inhibit acetylcholinesterase (AChE) by phosphylation of the active site serine, forming a stable conjugate: Ser-O-P(O)-(Y)-(XR) (where X can be O, N, or S and Y can be methyl, OR, or SR). ser-o-p 163-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 17698511-1 2007 Some organophosphorus compounds are toxic because they inhibit acetylcholinesterase (AChE) by phosphylation of the active site serine, forming a stable conjugate: Ser-O-P(O)-(Y)-(XR) (where X can be O, N, or S and Y can be methyl, OR, or SR). ser-o-p 163-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 17702992-0 2007 Concentration-dependent binding of chlorpyrifos oxon to acetylcholinesterase. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 35-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 17702992-1 2007 The organophosphorus insecticides have been known for many years to cause cholinergic crisis in humans as a result of the inhibition of the critical enzyme acetylcholinesterase. organophosphorus 4-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-176 17702992-3 2007 However, more recent studies have suggested that the interactions of certain anticholinesterase organophosphates with acetylcholinesterase are more complex than previously thought since their inhibitory capacity has been noted to change as a function of inhibitor concentration. Organophosphates 96-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 17702992-4 2007 In the present report, chlorpyrifos oxon (O,O-diethyl O-(3,5,6-trichloro-2-pyridyl) phosphate) was incubated with human recombinant acetylcholinesterase in the presence of p-nitrophenyl acetate in order to better characterize kinetically the interactions of this oxon with enzyme. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 23-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-152 17702992-4 2007 In the present report, chlorpyrifos oxon (O,O-diethyl O-(3,5,6-trichloro-2-pyridyl) phosphate) was incubated with human recombinant acetylcholinesterase in the presence of p-nitrophenyl acetate in order to better characterize kinetically the interactions of this oxon with enzyme. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 42-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-152 17702992-4 2007 In the present report, chlorpyrifos oxon (O,O-diethyl O-(3,5,6-trichloro-2-pyridyl) phosphate) was incubated with human recombinant acetylcholinesterase in the presence of p-nitrophenyl acetate in order to better characterize kinetically the interactions of this oxon with enzyme. 4-nitrophenyl acetate 172-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-152 17702992-4 2007 In the present report, chlorpyrifos oxon (O,O-diethyl O-(3,5,6-trichloro-2-pyridyl) phosphate) was incubated with human recombinant acetylcholinesterase in the presence of p-nitrophenyl acetate in order to better characterize kinetically the interactions of this oxon with enzyme. oxon 36-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-152 17702992-8 2007 These results suggest that the concentration-dependent interactions of chlorpyrifos oxon with acetylcholinesterase resulted from a different mechanism than the concentration-dependent interactions of acetylthiocholine. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 71-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 17702992-8 2007 These results suggest that the concentration-dependent interactions of chlorpyrifos oxon with acetylcholinesterase resulted from a different mechanism than the concentration-dependent interactions of acetylthiocholine. Acetylthiocholine 200-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 17702992-9 2007 In the latter case, substrate bound to the peripheral anionic site of acetylcholinesterase has been shown to reduce enzyme activity by blocking the release of the product thiocholine from the active site gorge. Thiocholine 171-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 17624398-9 2007 The formation of malaoxon, isomalathion or trimethyl phosphate esters correlated well with the induced toxicity (inhibition of acetylcholinesterase), which was observed in photocatalysis of malathion and Radotion, and in photolysis of malaoxon and Radotion. malaoxon 17-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 17624398-9 2007 The formation of malaoxon, isomalathion or trimethyl phosphate esters correlated well with the induced toxicity (inhibition of acetylcholinesterase), which was observed in photocatalysis of malathion and Radotion, and in photolysis of malaoxon and Radotion. isomalathion 27-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 17624398-9 2007 The formation of malaoxon, isomalathion or trimethyl phosphate esters correlated well with the induced toxicity (inhibition of acetylcholinesterase), which was observed in photocatalysis of malathion and Radotion, and in photolysis of malaoxon and Radotion. trimethyl phosphate esters 43-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 17624398-9 2007 The formation of malaoxon, isomalathion or trimethyl phosphate esters correlated well with the induced toxicity (inhibition of acetylcholinesterase), which was observed in photocatalysis of malathion and Radotion, and in photolysis of malaoxon and Radotion. malaoxon 235-243 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 18274286-5 2007 Among them, only quercetin showed a substantial inhibition (76.2%) against AChE, while genistein (65.7%), luteolin-7-O-rutinoside (54.9%), and silibinin (51.4%) exerted a moderate inhibition on BChE. Quercetin 17-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 17900152-1 2007 The reactivation of nerve agent-inhibited acetylcholinesterase (AChE) by oxime is the most important step in the treatment of nerve agent poisoning. Oximes 73-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 17900152-4 2007 Several investigations have demonstrated that the efficacy of an oxime primarily depends on its ability to reactivate nerve agent-inhibited AChE. Oximes 65-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 17900152-5 2007 If the in vitro oxime reactivation of nerve agent-inhibited animal AChE is similar to that of human AChE, it is likely that the results of an in vivo animal study will reliably extrapolate to humans. Oximes 16-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 17900152-7 2007 Reactivation kinetic studies with five mono- and bis-pyridinium oximes showed that oxime reactivation of nerve agent-inhibited human AChE in most cases was faster than guinea pig AChE. mono- and bis-pyridinium oximes 39-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 17900152-7 2007 Reactivation kinetic studies with five mono- and bis-pyridinium oximes showed that oxime reactivation of nerve agent-inhibited human AChE in most cases was faster than guinea pig AChE. Oximes 64-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 17900152-8 2007 The most significant enhancement was observed in the reactivation of human AChE inhibited by nerve agents containing bulky side chains GF, GD, and VR, by H-series oximes HLo-7, HI-6, and ICD-585. Gadolinium 139-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 17900152-8 2007 The most significant enhancement was observed in the reactivation of human AChE inhibited by nerve agents containing bulky side chains GF, GD, and VR, by H-series oximes HLo-7, HI-6, and ICD-585. h-series oximes 154-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 17900152-8 2007 The most significant enhancement was observed in the reactivation of human AChE inhibited by nerve agents containing bulky side chains GF, GD, and VR, by H-series oximes HLo-7, HI-6, and ICD-585. asoxime chloride 177-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 17681794-0 2007 Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer"s disease therapeutics. piperidine 57-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 17681794-1 2007 With the goal of developing Alzheimer"s disease therapeutics, we have designed and synthesized new piperidine derivatives having dual action of acetylcholinesterase (AChE) and beta-amyloid peptide (Abeta) aggregation inhibition. piperidine 99-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-164 17681794-1 2007 With the goal of developing Alzheimer"s disease therapeutics, we have designed and synthesized new piperidine derivatives having dual action of acetylcholinesterase (AChE) and beta-amyloid peptide (Abeta) aggregation inhibition. piperidine 99-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 17681794-2 2007 For binding with the catalytic site of AChE, an ester with aromatic group was designed, and for the peripheral site, another aromatic group was considered. Esters 48-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 17681794-8 2007 In the docking model, we confirmed that 4-chlorobenzene of 12 plays the parallel pi-pi stacking against the indole ring of Trp84 in the bottom gorge of AChE. chlorobenzene 40-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 17681794-9 2007 Because the benzyhydryl moiety of 12 covered the peripheral site of AChE in a funnel-like shape, 12 showed good inhibitory potency against AChE and could inhibit AChE-induced Abeta(1-42) peptide aggregation. benzyhydryl 12-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 17681794-9 2007 Because the benzyhydryl moiety of 12 covered the peripheral site of AChE in a funnel-like shape, 12 showed good inhibitory potency against AChE and could inhibit AChE-induced Abeta(1-42) peptide aggregation. benzyhydryl 12-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 17681794-9 2007 Because the benzyhydryl moiety of 12 covered the peripheral site of AChE in a funnel-like shape, 12 showed good inhibitory potency against AChE and could inhibit AChE-induced Abeta(1-42) peptide aggregation. benzyhydryl 12-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 17728068-0 2007 The CCAAT-binding factor CBF/NF-Y regulates the human acetylcholinesterase promoter activity during calcium ionophore A23187-induced cell apoptosis. Calcium 100-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 17728068-0 2007 The CCAAT-binding factor CBF/NF-Y regulates the human acetylcholinesterase promoter activity during calcium ionophore A23187-induced cell apoptosis. Calcimycin 118-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 17728068-1 2007 We previously reported that the expression of acetylcholinesterase during A23187-induced apoptosis of HeLa cells is regulated by Ca(2+) mobilization through the modulation of mRNA stability and acetylcholinesterase promoter activity. Calcimycin 74-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 17728068-1 2007 We previously reported that the expression of acetylcholinesterase during A23187-induced apoptosis of HeLa cells is regulated by Ca(2+) mobilization through the modulation of mRNA stability and acetylcholinesterase promoter activity. Calcimycin 74-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 194-214 17728068-2 2007 Transactivation of the human acetylcholinesterase promoter by A23187 was partially mediated by the distal CCAAT motif within the -1270 to -1248 fragment of the human acetylcholinesterase promoter, which was bound by the CCAAT binding factor (CBF/NF-Y). Calcimycin 62-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 17728068-2 2007 Transactivation of the human acetylcholinesterase promoter by A23187 was partially mediated by the distal CCAAT motif within the -1270 to -1248 fragment of the human acetylcholinesterase promoter, which was bound by the CCAAT binding factor (CBF/NF-Y). Calcimycin 62-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-186 17728068-3 2007 In the present study, we investigated the molecular mechanisms by which CBF/NF-Y regulates A23187-induced activation of the human acetylcholinesterase promoter. Calcimycin 91-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 17728068-6 2007 Our results suggest that acetylcholinesterase promoter activation during A23187-induced HeLa cell apoptosis may result partly from the dissociation of CBF/NF-Y from the distal CCAAT motif in the acetylcholinesterase promoter, reversing this suppression. Calcimycin 73-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 17728068-6 2007 Our results suggest that acetylcholinesterase promoter activation during A23187-induced HeLa cell apoptosis may result partly from the dissociation of CBF/NF-Y from the distal CCAAT motif in the acetylcholinesterase promoter, reversing this suppression. Calcimycin 73-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-215 17654703-4 2007 We report that, in astroglia and in an immortalized cell line, GH4-halpha7, acute oxidative stress causes influx of extracellular calcium through L-type voltage-gated calcium channels (L-VGCC), followed by increased release of AChE into the extracellular medium. GH4 63-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 227-231 17654703-4 2007 We report that, in astroglia and in an immortalized cell line, GH4-halpha7, acute oxidative stress causes influx of extracellular calcium through L-type voltage-gated calcium channels (L-VGCC), followed by increased release of AChE into the extracellular medium. halpha7 67-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 227-231 17654703-4 2007 We report that, in astroglia and in an immortalized cell line, GH4-halpha7, acute oxidative stress causes influx of extracellular calcium through L-type voltage-gated calcium channels (L-VGCC), followed by increased release of AChE into the extracellular medium. Calcium 130-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 227-231 17572053-5 2007 Acetylcholinesterase inhibitors may be useful in both these types of dementia: rivastigmine is approved for treating Parkinson disease dementia and clozapine for reducing hallucinations. Rivastigmine 79-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 17572053-5 2007 Acetylcholinesterase inhibitors may be useful in both these types of dementia: rivastigmine is approved for treating Parkinson disease dementia and clozapine for reducing hallucinations. Clozapine 148-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 17590326-4 2007 Four pesticides of carbaryl, malathion, dimethoate and monocrotophos were selected to discuss their inhibition efficiencies to AChE. Carbaryl 19-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 17590326-4 2007 Four pesticides of carbaryl, malathion, dimethoate and monocrotophos were selected to discuss their inhibition efficiencies to AChE. Malathion 29-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 17590326-4 2007 Four pesticides of carbaryl, malathion, dimethoate and monocrotophos were selected to discuss their inhibition efficiencies to AChE. Dimethoate 40-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 17590326-4 2007 Four pesticides of carbaryl, malathion, dimethoate and monocrotophos were selected to discuss their inhibition efficiencies to AChE. Monocrotophos 55-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 17590326-6 2007 Ninety-five percent reactivation of the inhibited AChE could be regenerated using pralidoxime iodide within 8 min. pralidoxime 82-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 18070496-0 2007 [Different therapeutic efficacy of pralidoxime chloride PAM-Cl on AChE against acute toxicity of methamidophos, dichlorvos and omethoate]. methamidophos 97-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 18070496-0 2007 [Different therapeutic efficacy of pralidoxime chloride PAM-Cl on AChE against acute toxicity of methamidophos, dichlorvos and omethoate]. Dichlorvos 112-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 18070496-0 2007 [Different therapeutic efficacy of pralidoxime chloride PAM-Cl on AChE against acute toxicity of methamidophos, dichlorvos and omethoate]. dimethoxon 127-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 18070496-8 2007 CONCLUSION: After the treatment of PAM-Cl, the AChE activities of the patients with acute methamidophos poisoning could be continuously reactivated, the AChE activities of the patients with acute DDV/DEP poisoning could also be reactivated in 12 hours, and then keep stable, but the AChE activities of the patients with acute omethoate/dimethoate poisoning could not be reactivated. methamidophos 90-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 17955784-1 2007 The efficacy of the acetylcholinesterase inhibitors donepezil, galantamine and rivastigmine for Alzheimer"s disease is well-documented by a number of studies. Donepezil 52-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 17955784-1 2007 The efficacy of the acetylcholinesterase inhibitors donepezil, galantamine and rivastigmine for Alzheimer"s disease is well-documented by a number of studies. Galantamine 63-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 17955784-1 2007 The efficacy of the acetylcholinesterase inhibitors donepezil, galantamine and rivastigmine for Alzheimer"s disease is well-documented by a number of studies. Rivastigmine 79-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 19662135-4 2007 In view of this, we have synthesized novel 3-aryl-N-methyl-1,2,5,6-tetrahydropyridine derivatives 5a-k by Suzuki coupling and screened the efficacy of these derivatives for their AChE inhibitor activity. 3-aryl-n-methyl-1,2,5,6-tetrahydropyridine 43-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 179-183 17436196-8 2007 In conclusion, the stimulation of AChE and Na (+),K (+)-ATPase by the training may be due to the rise of blood catecholamine oxidation contributing to TAS decrease and/or the increase of serotonin levels. Catecholamines 111-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 17913689-6 2007 Second, through a novel chemistry, termed freeze-frame, click chemistry, we have used organophosphate conjugates of acetylcholinesterase as templates for the synthesis of novel nucleophilic reactivating agents. Organophosphates 86-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 17913689-7 2007 Finally, acetylcholinesterase can be modified through cysteine substitution mutagenesis and attachment of fluorophores at the substitution positions. Cysteine 54-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 17913689-8 2007 When linked at certain locations in the molecule, the attached fluorophore is sensitive to organophosphate conjugation with acetylcholinesterase, and thus the very target of insecticide or nerve agent action becomes a detection molecule for organophosphate exposure. Organophosphates 91-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 17913689-8 2007 When linked at certain locations in the molecule, the attached fluorophore is sensitive to organophosphate conjugation with acetylcholinesterase, and thus the very target of insecticide or nerve agent action becomes a detection molecule for organophosphate exposure. Organophosphates 241-256 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 17913691-0 2007 Red blood cell acetylcholinesterase and plasma butyrylcholinesterase status: important indicators for the treatment of patients poisoned by organophosphorus compounds. Organophosphorus Compounds 140-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 17913691-1 2007 Inhibition of acetylcholinesterase (AChE) is regarded as the primary toxic mechanism of organophosphorus compounds (OP). Organophosphorus Compounds 88-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 17913691-1 2007 Inhibition of acetylcholinesterase (AChE) is regarded as the primary toxic mechanism of organophosphorus compounds (OP). Organophosphorus Compounds 88-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 17913691-2 2007 Therapeutic strategies are directed to antagonise overstimulation of muscarinic receptors with atropine and to reactivate inhibited AChE with oximes. Oximes 142-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 17913691-8 2007 After administration of HI-6, RBC-AChE activity increased rapidly. asoxime chloride 24-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 17913691-11 2007 Oxime administration can be stopped when AChE is aged completely, but has to be continued as long as poison is present in the body and reactivation is possible. Oximes 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 17601647-0 2007 Interactions of Lycopodium alkaloids with acetylcholinesterase investigated by 1H NMR relaxation rate. lycopodium alkaloids 16-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 17601647-0 2007 Interactions of Lycopodium alkaloids with acetylcholinesterase investigated by 1H NMR relaxation rate. Hydrogen 79-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 17601647-5 2007 The results indicate that investigation of 1H NMR relaxation data is a useful method to locate the new Lycopodium alkaloids as AchE inhibitors. Hydrogen 43-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 17601647-5 2007 The results indicate that investigation of 1H NMR relaxation data is a useful method to locate the new Lycopodium alkaloids as AchE inhibitors. lycopodium alkaloids 103-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 18320105-2 2007 OBJECTIVE: Exposure to organophosphorus and carbamate pesticides and carbamates was established in the agricultural population of Putumayo by determining acetylcholinesterase levels. organophosphorus 23-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-174 18320105-2 2007 OBJECTIVE: Exposure to organophosphorus and carbamate pesticides and carbamates was established in the agricultural population of Putumayo by determining acetylcholinesterase levels. Carbamates 44-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-174 17443135-1 2007 Organophosphorus compound-based nerve agents inhibit the essential enzyme acetylcholinesterase (AChE) causing acute toxicity and death. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 17443135-1 2007 Organophosphorus compound-based nerve agents inhibit the essential enzyme acetylcholinesterase (AChE) causing acute toxicity and death. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 17443135-2 2007 Clinical treatment of nerve-agent poisoning is to use oxime-based antidotes to reactivate the inhibited AChE. Oximes 54-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 17443135-4 2007 To design improved oximes, crystal structures of a tabun-conjugated AChE in complex with different oximes are needed to guide the structural modifications of known antidotes. Oximes 19-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 17443135-4 2007 To design improved oximes, crystal structures of a tabun-conjugated AChE in complex with different oximes are needed to guide the structural modifications of known antidotes. Oximes 99-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 17475919-2 2007 A relevant example is that of the stress-induced, normally rare, and naturally unstable "read-through" human acetylcholinesterase variant, AChE-R. AChE-R shares its active site with the synaptic AChE-S variant, which is the target of poisonous organophosphate anticholinesterase insecticides such as the parathion metabolite paraoxon. Parathion 304-313 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 17475919-2 2007 A relevant example is that of the stress-induced, normally rare, and naturally unstable "read-through" human acetylcholinesterase variant, AChE-R. AChE-R shares its active site with the synaptic AChE-S variant, which is the target of poisonous organophosphate anticholinesterase insecticides such as the parathion metabolite paraoxon. Parathion 304-313 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 17475919-2 2007 A relevant example is that of the stress-induced, normally rare, and naturally unstable "read-through" human acetylcholinesterase variant, AChE-R. AChE-R shares its active site with the synaptic AChE-S variant, which is the target of poisonous organophosphate anticholinesterase insecticides such as the parathion metabolite paraoxon. Parathion 304-313 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 17475919-2 2007 A relevant example is that of the stress-induced, normally rare, and naturally unstable "read-through" human acetylcholinesterase variant, AChE-R. AChE-R shares its active site with the synaptic AChE-S variant, which is the target of poisonous organophosphate anticholinesterase insecticides such as the parathion metabolite paraoxon. Paraoxon 325-333 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 17475919-2 2007 A relevant example is that of the stress-induced, normally rare, and naturally unstable "read-through" human acetylcholinesterase variant, AChE-R. AChE-R shares its active site with the synaptic AChE-S variant, which is the target of poisonous organophosphate anticholinesterase insecticides such as the parathion metabolite paraoxon. Paraoxon 325-333 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 17475919-2 2007 A relevant example is that of the stress-induced, normally rare, and naturally unstable "read-through" human acetylcholinesterase variant, AChE-R. AChE-R shares its active site with the synaptic AChE-S variant, which is the target of poisonous organophosphate anticholinesterase insecticides such as the parathion metabolite paraoxon. Paraoxon 325-333 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 17475919-3 2007 Inherent AChE-R overproduction under organophosphate intoxication confers both short-term protection (as a bioscavenger) and long-term neuromuscular damages (as a regulator). Organophosphates 37-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 17475919-5 2007 AChE-R(ER) purified to homogeneity showed indistinguishable biochemical properties, with IC50 = 10(-7) M for the organophosphate paraoxon, similar to mammalian cell culture-derived AChE. Organophosphates 113-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 17475919-5 2007 AChE-R(ER) purified to homogeneity showed indistinguishable biochemical properties, with IC50 = 10(-7) M for the organophosphate paraoxon, similar to mammalian cell culture-derived AChE. Paraoxon 129-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 17475919-8 2007 Our findings present plant-produced AChE-R(ER) as a bimodal agent, conferring both short- and long-term protection from organophosphate intoxication. Organophosphates 120-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 17920128-4 2007 In fact, a number of cholinergic synaptic mechanisms are putative targets for manganese activity: presynaptic choline uptake, quantal release of acetylcholine into the synaptic cleft, postsynaptic binding of acetylcholine to receptors and its synaptic degradation by acetylcholinesterase. Manganese 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 267-287 18069241-2 2007 Among the alkaloids tested, only capsaicin exerted a remarkable inhibitory effect towards both AChE and BChE [(62.7 +/- 0.79)% and (75.3 +/- 0.98)%, respectively]. Alkaloids 10-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 18069241-2 2007 Among the alkaloids tested, only capsaicin exerted a remarkable inhibitory effect towards both AChE and BChE [(62.7 +/- 0.79)% and (75.3 +/- 0.98)%, respectively]. Capsaicin 33-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 17499494-0 2007 Immobilization of acetylcholinesterase on gold nanoparticles embedded in sol-gel film for amperometric detection of organophosphorous insecticide. organophosphorous 116-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 17499494-1 2007 A simple method to immobilize acetylcholinesterase (AChE) on silica sol-gel (SiSG) film assembling gold nanoparticles (AuNPs) was proposed, thus a sensitive, fast and stable amperometric sensor for quantitative determination of organophosphorous insecticide was developed. Silicon Dioxide 61-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 17499494-1 2007 A simple method to immobilize acetylcholinesterase (AChE) on silica sol-gel (SiSG) film assembling gold nanoparticles (AuNPs) was proposed, thus a sensitive, fast and stable amperometric sensor for quantitative determination of organophosphorous insecticide was developed. Silicon Dioxide 61-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 17499494-1 2007 A simple method to immobilize acetylcholinesterase (AChE) on silica sol-gel (SiSG) film assembling gold nanoparticles (AuNPs) was proposed, thus a sensitive, fast and stable amperometric sensor for quantitative determination of organophosphorous insecticide was developed. organophosphorous 228-245 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 17499494-1 2007 A simple method to immobilize acetylcholinesterase (AChE) on silica sol-gel (SiSG) film assembling gold nanoparticles (AuNPs) was proposed, thus a sensitive, fast and stable amperometric sensor for quantitative determination of organophosphorous insecticide was developed. organophosphorous 228-245 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 17499494-3 2007 The immobilized AChE could catalyze the hydrolysis of acetylthiocholine chloride (ATCl) with a Kmapp value of 450 microM to form thiocholine, which was then oxidized to produce detectable single with a linear range of 10-1000 microM. Acetylthiocholine chloride 54-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 17499494-3 2007 The immobilized AChE could catalyze the hydrolysis of acetylthiocholine chloride (ATCl) with a Kmapp value of 450 microM to form thiocholine, which was then oxidized to produce detectable single with a linear range of 10-1000 microM. atcl 82-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 17499494-3 2007 The immobilized AChE could catalyze the hydrolysis of acetylthiocholine chloride (ATCl) with a Kmapp value of 450 microM to form thiocholine, which was then oxidized to produce detectable single with a linear range of 10-1000 microM. Thiocholine 60-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 17499494-5 2007 Based on the inhibition of organophosphorous insecticide on the enzymatic activity of AChE, using monocrotophos as a model compound, the conditions for detection of the insecticide were optimized. organophosphorous 27-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 17499494-5 2007 Based on the inhibition of organophosphorous insecticide on the enzymatic activity of AChE, using monocrotophos as a model compound, the conditions for detection of the insecticide were optimized. Monocrotophos 98-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 17436196-8 2007 In conclusion, the stimulation of AChE and Na (+),K (+)-ATPase by the training may be due to the rise of blood catecholamine oxidation contributing to TAS decrease and/or the increase of serotonin levels. Serotonin 187-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 17847708-1 2007 Nine potential non-symmetrical xylene-bridged AChE reactivators were synthesized using modifications of currently known synthetic pathways. Xylenes 31-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 17847708-2 2007 Their potency to reactivate AChE inhibited by the nerve agent tabun and the insecticide paraoxon together with nine symmetrical xylene-bridged compounds, was tested in vitro. Paraoxon 88-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 17847708-3 2007 Seven compounds were promising against paraoxon-inhibited AChE. Paraoxon 39-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 17653364-1 2007 A great number of natural products, especially alkaloids, which exhibit a range of biological activities including acetylcholinesterase inhibition and antineoplastic, cardiovascular and immunostimulatory activities, have been isolated from the plants of the Amaryllidaceae family. Alkaloids 47-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 17532308-7 2007 The results demonstrated that AChE activity in both high (345.5 microkat/gHb) and low exposure periods (496.9 microkat/gHb) of the exposed group were significantly different from control group (649.7 microkat/gHb, p<0.01). 4-hydroxybutyric acid 73-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 17960099-2 2007 This compound represents a new acetylcholinesterase (AChE) reactivator, which has no substituents on the second pyridinium ring as found in other commonly used AChE reactivators. pyridine 112-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 17960099-2 2007 This compound represents a new acetylcholinesterase (AChE) reactivator, which has no substituents on the second pyridinium ring as found in other commonly used AChE reactivators. pyridine 112-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 17960099-3 2007 The reactivation ability of this reactivator was tested on tabun- and cyclosarin-inhibited AChE. cyclohexyl methylphosphonofluoridate 70-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 17960099-4 2007 According to the results obtained, the new compound (without substitution and with decreased molecule size) showed increased reactivation potency in case of cyclosarin inhibited AChE. cyclohexyl methylphosphonofluoridate 157-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-182 17532308-7 2007 The results demonstrated that AChE activity in both high (345.5 microkat/gHb) and low exposure periods (496.9 microkat/gHb) of the exposed group were significantly different from control group (649.7 microkat/gHb, p<0.01). 4-hydroxybutyric acid 119-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 17929660-0 2007 Effect of a tetraalkylammonium derivative of 6-methyluracil from a new class of acetylcholinesterase inhibitors on the endplate potential amplitude in muscles of different function types under high-frequency nerve stimulation. tetraalkylammonium 12-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 17929660-0 2007 Effect of a tetraalkylammonium derivative of 6-methyluracil from a new class of acetylcholinesterase inhibitors on the endplate potential amplitude in muscles of different function types under high-frequency nerve stimulation. 6-methyluracil 45-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 17654339-0 2007 Molecular modelling and enzymatic studies of acetylcholinesterase and butyrylcholinesterase recognition with paraquat and related compounds. Paraquat 109-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 17532308-7 2007 The results demonstrated that AChE activity in both high (345.5 microkat/gHb) and low exposure periods (496.9 microkat/gHb) of the exposed group were significantly different from control group (649.7 microkat/gHb, p<0.01). 4-hydroxybutyric acid 119-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 17555296-9 2007 On the basis of measured sensitivities, phenyl valerate was the preferred substrate for NEST and BChE, whereas phenyl acetate was better for AChE. phenyl acetate 111-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 17322413-2 2007 We utilized pyridostigmine, an acetylcholinesterase inhibitor that selectively augments the parasympathetic efferent signal, to further characterize parasympathetic regulation of rest and postexercise heart rate. Pyridostigmine Bromide 12-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 17451950-0 2007 Derivatives of oxoisoaporphine alkaloids: a novel class of selective acetylcholinesterase inhibitors. oxoisoaporphine alkaloids 15-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 17627484-3 2007 Cholinesterase inhibitors has been purported to enhance cognitive function, and previous clinical trials consistently showed that donepezil, a reversible inhibitor of acetylcholinesterase (AChE), led to statistically significant improvements in cognition and patient function. Donepezil 130-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-187 17627484-3 2007 Cholinesterase inhibitors has been purported to enhance cognitive function, and previous clinical trials consistently showed that donepezil, a reversible inhibitor of acetylcholinesterase (AChE), led to statistically significant improvements in cognition and patient function. Donepezil 130-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-193 17484756-1 2007 PURPOSE: To determine whether an acetylcholinesterase inhibitor, such as donepezil, would improve memory or other cognitive/psychological functions in epilepsy patients with subjective memory complaints. Donepezil 73-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 17656829-2 2007 The mechanism of action that is most generally recognized as underlying the clinical benefits of galantamine is inhibition of brain acetylcholinesterase (AChE). Galantamine 97-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-152 17656829-2 2007 The mechanism of action that is most generally recognized as underlying the clinical benefits of galantamine is inhibition of brain acetylcholinesterase (AChE). Galantamine 97-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-158 17656829-5 2007 In general, these studies provide evidence of effects beyond those of AChE inhibition alone, most notably in comparisons with other AChE inhibitors, in which galantamine produced similar or greater effects at doses that provided lower levels of brain AChE inhibition. Galantamine 158-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 17656829-5 2007 In general, these studies provide evidence of effects beyond those of AChE inhibition alone, most notably in comparisons with other AChE inhibitors, in which galantamine produced similar or greater effects at doses that provided lower levels of brain AChE inhibition. Galantamine 158-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 18085124-3 2007 Organophosphate compounds inhibit acetylcholinesterase resulting in acute toxicity. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 17324568-3 2007 To construct an electrochemical enzyme immunoassay system by using the sensor, the enzyme chemistry of acetylcholinesterase (AChE) to generate a thiol compound was used and combined with the enzyme-linked immunosorbent assays (ELISA). Sulfhydryl Compounds 145-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 17324568-3 2007 To construct an electrochemical enzyme immunoassay system by using the sensor, the enzyme chemistry of acetylcholinesterase (AChE) to generate a thiol compound was used and combined with the enzyme-linked immunosorbent assays (ELISA). Sulfhydryl Compounds 145-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 17324568-4 2007 After the AChE-catalyzed reaction, the amount of the antigen was obtained by detecting the adsorbing rate of the generated thiol compound on the gold electrode using the FET sensor. Sulfhydryl Compounds 123-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-14 17562604-3 2007 Tabun-inhibited human erythrocyte acetylcholinesterase was completely reactivated only by the most flexible bispyridinium aldoxime - TMB-4 with a propylene chain between two rings. tabun 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 17562604-3 2007 Tabun-inhibited human erythrocyte acetylcholinesterase was completely reactivated only by the most flexible bispyridinium aldoxime - TMB-4 with a propylene chain between two rings. bispyridinium aldoxime - tmb-4 108-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 17562604-3 2007 Tabun-inhibited human erythrocyte acetylcholinesterase was completely reactivated only by the most flexible bispyridinium aldoxime - TMB-4 with a propylene chain between two rings. propylene 146-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 17679544-1 2007 The hexane extract of the fruit of Schizandra chinensis (Schisandraceae) was found to show significant inhibition of the activity of acetylcholinesterase enzyme (AChE). Hexanes 4-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-166 17679544-2 2007 In further studies, fourteen lignans were isolated, and evaluated for their inhibitory effect on AChE. Lignans 29-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 17382909-0 2007 Kinetic analysis of reactivation and aging of human acetylcholinesterase inhibited by different phosphoramidates. phosphoramidic acid 96-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 17382909-3 2007 Reactivators (oximes) of inhibited AChE are a mainstay of treatment. Oximes 14-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 17382909-4 2007 However, human AChE inhibited by certain OP, e.g. the phosphoramidates tabun and fenamiphos, is rather resistant towards reactivation by oximes while AChE inhibited by others, e.g. the phosphoramidate methamidophos is easily reactivated by oximes. phosphoramidates tabun 54-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 17382909-4 2007 However, human AChE inhibited by certain OP, e.g. the phosphoramidates tabun and fenamiphos, is rather resistant towards reactivation by oximes while AChE inhibited by others, e.g. the phosphoramidate methamidophos is easily reactivated by oximes. phosphoramidates tabun 54-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 17382909-4 2007 However, human AChE inhibited by certain OP, e.g. the phosphoramidates tabun and fenamiphos, is rather resistant towards reactivation by oximes while AChE inhibited by others, e.g. the phosphoramidate methamidophos is easily reactivated by oximes. fenamiphos 81-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 17382909-4 2007 However, human AChE inhibited by certain OP, e.g. the phosphoramidates tabun and fenamiphos, is rather resistant towards reactivation by oximes while AChE inhibited by others, e.g. the phosphoramidate methamidophos is easily reactivated by oximes. fenamiphos 81-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 17382909-4 2007 However, human AChE inhibited by certain OP, e.g. the phosphoramidates tabun and fenamiphos, is rather resistant towards reactivation by oximes while AChE inhibited by others, e.g. the phosphoramidate methamidophos is easily reactivated by oximes. Oximes 137-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 17382909-4 2007 However, human AChE inhibited by certain OP, e.g. the phosphoramidates tabun and fenamiphos, is rather resistant towards reactivation by oximes while AChE inhibited by others, e.g. the phosphoramidate methamidophos is easily reactivated by oximes. phosphoramidate methamidophos 185-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 17382909-4 2007 However, human AChE inhibited by certain OP, e.g. the phosphoramidates tabun and fenamiphos, is rather resistant towards reactivation by oximes while AChE inhibited by others, e.g. the phosphoramidate methamidophos is easily reactivated by oximes. Oximes 240-246 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 17382909-5 2007 To get more insight into a potential structure-activity relationship human AChE was inhibited by 16 different tabun analogues and the time-dependent reactivation by 1mM obidoxime, TMB-4, MMB-4, HI 6 or HLo 7, the reactivation kinetics of obidoxime and the kinetics of aging and spontaneous reactivation were investigated. Obidoxime Chloride 169-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 17382909-5 2007 To get more insight into a potential structure-activity relationship human AChE was inhibited by 16 different tabun analogues and the time-dependent reactivation by 1mM obidoxime, TMB-4, MMB-4, HI 6 or HLo 7, the reactivation kinetics of obidoxime and the kinetics of aging and spontaneous reactivation were investigated. Trimedoxime 180-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 17382909-5 2007 To get more insight into a potential structure-activity relationship human AChE was inhibited by 16 different tabun analogues and the time-dependent reactivation by 1mM obidoxime, TMB-4, MMB-4, HI 6 or HLo 7, the reactivation kinetics of obidoxime and the kinetics of aging and spontaneous reactivation were investigated. Obidoxime Chloride 238-247 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 17382909-6 2007 A clear structure-activity relationship of aging, spontaneous and oxime-induced reactivation kinetics could be determined with AChE inhibited by N-monoalkyl tabun analogues depending on the chain length of the N-alkyl residue. Oximes 66-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 17382909-6 2007 A clear structure-activity relationship of aging, spontaneous and oxime-induced reactivation kinetics could be determined with AChE inhibited by N-monoalkyl tabun analogues depending on the chain length of the N-alkyl residue. n-monoalkyl tabun 145-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 17382909-8 2007 AChE inhibited by phosphonoamidate analogues of tabun, bearing a N,N-dimethyl and N,N-diethyl group, could be reactivated and had comparable reactivation kinetics with obidoxime. phosphonoamidate 18-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 17382909-8 2007 AChE inhibited by phosphonoamidate analogues of tabun, bearing a N,N-dimethyl and N,N-diethyl group, could be reactivated and had comparable reactivation kinetics with obidoxime. Obidoxime Chloride 168-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 17382909-9 2007 These results in conjunction with previous data with organophosphates and organophosphonates emphasizes the necessity for kinetic studies as basis for future work on structural analysis with human AChE and for the development of effective broad-spectrum oximes. Organophosphates 53-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-201 17382909-9 2007 These results in conjunction with previous data with organophosphates and organophosphonates emphasizes the necessity for kinetic studies as basis for future work on structural analysis with human AChE and for the development of effective broad-spectrum oximes. Organophosphonates 74-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-201 17504354-1 2007 Organophosphates cause poisoning as a result of the excessive accumulation of acetylcholine at the cholinergic synapses due to inhibition of acetylcholinesterase (ChE). Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 17679544-4 2007 These results indicate that the lignans could potentially be a potent class of AChE inhibitors. Lignans 32-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 17516995-10 2007 Inhibitory effects of irinotecan on enzyme acetylcholinesterase (AChE) were studied in erythrocytes. Irinotecan 22-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 17516995-10 2007 Inhibitory effects of irinotecan on enzyme acetylcholinesterase (AChE) were studied in erythrocytes. Irinotecan 22-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 17516995-12 2007 Irinotecan was found to be strong inhibitor of the acetylcholine hydrolysis and to cause a continuous decrease of catalytic activity of AChE. Irinotecan 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 17383875-1 2007 Six novel AChE reactivators with a (Z)-but-2-ene linker were synthesized using the known synthetic pathways. 2-butene 35-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-14 17383875-2 2007 Their ability to reactivate AChE, which had been previously inhibited by nerve agent tabun or pesticide paraoxon, was tested in vitro and compared to pralidoxime, HI-6, obidoxime, and K075. Paraoxon 104-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 17383875-3 2007 The novel synthesized compounds were found to be ineffective against GA-inhibited AChE but the ability of (Z)-1,4-bis(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide to reactivate paraoxon-inhibited AChE was comparable with that of oxime K075. (z)-1,4-bis(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide 106-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 203-207 17383875-4 2007 Notably, the oxime group in position four substantially increased the ability of the novel compounds to reactivate paraoxon-inhibited AChE. Oximes 13-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 17383875-4 2007 Notably, the oxime group in position four substantially increased the ability of the novel compounds to reactivate paraoxon-inhibited AChE. Paraoxon 115-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 17503257-0 2007 Potency of five structurally different acetylcholinesterase reactivators to reactivate human brain cholinesterases inhibited by cyclosarin. cyclohexyl methylphosphonofluoridate 128-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 17503257-1 2007 Acetylcholinesterase (AChE; EC 3.1.1.7) reactivators are used as a part of the antidotal therapy of organophosphorus pesticide and nerve agent intoxications. organophosphorus 100-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 17503257-1 2007 Acetylcholinesterase (AChE; EC 3.1.1.7) reactivators are used as a part of the antidotal therapy of organophosphorus pesticide and nerve agent intoxications. organophosphorus 100-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 17503257-3 2007 In this article, we compared the reactivation potency of five structurally different AChE reactivators (pralidoxime, trimedoxime, methoxime, HS-6, and BI-6) to reactivate cyclosarin-inhibited cholinesterases of human brain. pralidoxime 104-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 17503257-3 2007 In this article, we compared the reactivation potency of five structurally different AChE reactivators (pralidoxime, trimedoxime, methoxime, HS-6, and BI-6) to reactivate cyclosarin-inhibited cholinesterases of human brain. Trimedoxime 117-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 17503257-3 2007 In this article, we compared the reactivation potency of five structurally different AChE reactivators (pralidoxime, trimedoxime, methoxime, HS-6, and BI-6) to reactivate cyclosarin-inhibited cholinesterases of human brain. N,N'-monomethylenebis(pyridiniumaldoxime) 130-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 17503257-3 2007 In this article, we compared the reactivation potency of five structurally different AChE reactivators (pralidoxime, trimedoxime, methoxime, HS-6, and BI-6) to reactivate cyclosarin-inhibited cholinesterases of human brain. HS 6 141-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 17503257-3 2007 In this article, we compared the reactivation potency of five structurally different AChE reactivators (pralidoxime, trimedoxime, methoxime, HS-6, and BI-6) to reactivate cyclosarin-inhibited cholinesterases of human brain. BI 6 151-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 17503257-3 2007 In this article, we compared the reactivation potency of five structurally different AChE reactivators (pralidoxime, trimedoxime, methoxime, HS-6, and BI-6) to reactivate cyclosarin-inhibited cholinesterases of human brain. cyclohexyl methylphosphonofluoridate 171-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 17504354-1 2007 Organophosphates cause poisoning as a result of the excessive accumulation of acetylcholine at the cholinergic synapses due to inhibition of acetylcholinesterase (ChE). Acetylcholine 78-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 17508773-2 2007 Many drugs currently used for the treatment of the AD are based on the improvement of cholinergic neurotransmission achieved by Acetylcholinesterase (AChE) inhibition, the enzyme responsible for acetylcholine hydrolysis. Acetylcholine 195-208 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 17326766-1 2007 We analyzed whether donepezil differently influences acetylcholinesterase (AChE) variants from cerebrospinal fluid (CSF) in patients with Alzheimer"s disease (AD) after long-term treatment. Donepezil 20-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 17326766-4 2007 When patients were re-examined after 12 months treatment with donepezil, there was a remarkable increase in both the G(4) and the lighter species of CSF AChE. Donepezil 62-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 17326766-5 2007 As compared with placebo, donepezil caused decreases in the percentage of AChE that failed to bind to the lectin concanavalin A and the antibody AE1. Donepezil 26-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 17326766-8 2007 Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis showed that a 77-kDa band, attributed in part to inactive AChE, was lower in AD patients than in controls. sodium dodecyl sulfate-polyacrylamide 0-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 17679544-0 2007 Acetylcholinesterase inhibitory effect of lignans isolated from Schizandra chinensis. Lignans 42-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 17679544-1 2007 The hexane extract of the fruit of Schizandra chinensis (Schisandraceae) was found to show significant inhibition of the activity of acetylcholinesterase enzyme (AChE). Hexanes 4-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-160 17374745-0 2007 The acetylcholinesterase inhibitor galantamine inhibits d-amphetamine-induced psychotic-like behavior in Cebus monkeys. Galantamine 35-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 17374745-0 2007 The acetylcholinesterase inhibitor galantamine inhibits d-amphetamine-induced psychotic-like behavior in Cebus monkeys. Dextroamphetamine 56-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 17374745-2 2007 Centrally acting selective muscarinic receptor agonists are currently not available for clinical use, but acetylcholinesterase (AChE) inhibitors, which indirectly stimulate AChR by blocking the breakdown of acetylcholine by AChE, are widely used in the clinic against Alzheimer"s disease. Acetylcholine 106-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 17508773-2 2007 Many drugs currently used for the treatment of the AD are based on the improvement of cholinergic neurotransmission achieved by Acetylcholinesterase (AChE) inhibition, the enzyme responsible for acetylcholine hydrolysis. Acetylcholine 195-208 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 17289401-4 2007 Acetylcholinesterase and gamma-cyclodextrin induced a characteristic ThT fluorescence similar to that with amyloid fibrils, whereas beta-cyclodextrin and the beta-sheet-rich transthyretin did not. thioflavin T 69-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 17289401-5 2007 The cavities of acetylcholinesterase and gamma-cyclodextrin were of similar diameter and only these cavities could accommodate two ThT ions according to molecular modelling. thioflavin T 131-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 17508773-3 2007 We have focused in this work on the usage of computer-aided molecular design by virtual screening, molecular dynamics with implicit and explicit water solvation, density functional, molecular interaction field studies, docking procedures, ADMET predictions in order to propose novel potential AChE inhibitor for the treatment of Alzheimer"s disease. Water 145-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 293-297 17724973-2 2007 Presently three AChE inhibitors are approved for the treatment of mild to moderately severe Alzheimer dementia: donepezil, rivastigmine and galantamine. Donepezil 112-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 17300836-3 2007 Acetylthiocholine and butyrylthiocholine (identified in mammalian studies as diagnostic substrates for AChE and BChE respectively) were hydrolyzed mainly, but not exclusively, by these enzymes. Acetylthiocholine 0-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 17300836-3 2007 Acetylthiocholine and butyrylthiocholine (identified in mammalian studies as diagnostic substrates for AChE and BChE respectively) were hydrolyzed mainly, but not exclusively, by these enzymes. Butyrylthiocholine 22-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 17300836-4 2007 The inhibitors BW284C51 and iso-OMPA (identified in mammalian studies as diagnostic inhibitors of AChE and BChE respectively) were not specific for these enzymes in marbled sole. Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide 15-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 17300836-4 2007 The inhibitors BW284C51 and iso-OMPA (identified in mammalian studies as diagnostic inhibitors of AChE and BChE respectively) were not specific for these enzymes in marbled sole. Tetraisopropylpyrophosphamide 28-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 17300836-9 2007 Brain AChE was relatively insensitive to IBP, but muscle AChE and BChE were sensitive to IBP concentrations in the high nM range. O,O-diisopropyl-S-benzylthiophosphate 89-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 19300564-5 2007 Some potential effects of donepezil on the AD brain, leading to reduced cortico-hippocampal atrophy, include the following: AChE inhibition, enhancement of cholinergic neurotransmission and putative modulation of other neurotransmitter systems, protection against glutamate-induced excitotoxicity, activation of neurotrophic mechanisms, promotion of non-amyloidodgenic pathways for APP processing, and indirect effects on cerebrovascular function improving brain perfusion. Donepezil 26-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 17467020-0 2007 Concentration-dependent interactions of the organophosphates chlorpyrifos oxon and methyl paraoxon with human recombinant acetylcholinesterase. Organophosphates 44-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 17467020-0 2007 Concentration-dependent interactions of the organophosphates chlorpyrifos oxon and methyl paraoxon with human recombinant acetylcholinesterase. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 61-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 17467020-0 2007 Concentration-dependent interactions of the organophosphates chlorpyrifos oxon and methyl paraoxon with human recombinant acetylcholinesterase. methylparaoxon 83-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 17467020-1 2007 For many decades it has been thought that oxygen analogs (oxons) of organophosphorus insecticides phosphorylate the catalytic site of acetylcholinesterase by a mechanism that follows simple Michaelis-Menten kinetics. Oxygen 42-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 17467020-1 2007 For many decades it has been thought that oxygen analogs (oxons) of organophosphorus insecticides phosphorylate the catalytic site of acetylcholinesterase by a mechanism that follows simple Michaelis-Menten kinetics. organophosphorus 68-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 17467020-3 2007 The current study has investigated the interactions of chlorpyrifos oxon and methyl paraoxon with human recombinant acetylcholinesterase. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 55-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 17467020-3 2007 The current study has investigated the interactions of chlorpyrifos oxon and methyl paraoxon with human recombinant acetylcholinesterase. methylparaoxon 77-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 17467020-7 2007 Collectively, these results demonstrate that the interactions of chlorpyrifos oxon and methyl paraoxon with acetylcholinesterase cannot be described by simple Michaelis-Menten kinetics but instead support the hypothesis that these oxons bind to a secondary site on acetylcholinesterase, leading to activation/inhibition of the catalytic site, depending on the nature of the substrate and inhibitor. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 65-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 17467020-7 2007 Collectively, these results demonstrate that the interactions of chlorpyrifos oxon and methyl paraoxon with acetylcholinesterase cannot be described by simple Michaelis-Menten kinetics but instead support the hypothesis that these oxons bind to a secondary site on acetylcholinesterase, leading to activation/inhibition of the catalytic site, depending on the nature of the substrate and inhibitor. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 65-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 265-285 17467020-7 2007 Collectively, these results demonstrate that the interactions of chlorpyrifos oxon and methyl paraoxon with acetylcholinesterase cannot be described by simple Michaelis-Menten kinetics but instead support the hypothesis that these oxons bind to a secondary site on acetylcholinesterase, leading to activation/inhibition of the catalytic site, depending on the nature of the substrate and inhibitor. Paraoxon 94-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 17467020-7 2007 Collectively, these results demonstrate that the interactions of chlorpyrifos oxon and methyl paraoxon with acetylcholinesterase cannot be described by simple Michaelis-Menten kinetics but instead support the hypothesis that these oxons bind to a secondary site on acetylcholinesterase, leading to activation/inhibition of the catalytic site, depending on the nature of the substrate and inhibitor. Paraoxon 94-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 265-285 17229443-10 2007 Therefore, we examined AChE activity in A549 cells upon induction of apoptosis by SM (100-500 microM). Mustard Gas 82-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 17724973-2 2007 Presently three AChE inhibitors are approved for the treatment of mild to moderately severe Alzheimer dementia: donepezil, rivastigmine and galantamine. Rivastigmine 123-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 17724973-2 2007 Presently three AChE inhibitors are approved for the treatment of mild to moderately severe Alzheimer dementia: donepezil, rivastigmine and galantamine. Galantamine 140-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 17428437-5 2007 The complexity of the BChE inhibitory effect of phenoxazine/phenothiazine dyes contrasted with that of conventional ChE inhibitors which cause single-occupancy (n=1), competitive or mixed inhibition in both AChE and BChE and signaled novel modes of ligand interaction at (or remote from) the active site gorge of the latter enzyme. phenoxazine 48-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-211 17660172-2 2007 The purpose of this study was to detect brain perfusion changes and the effects of rivastigmine, an acetylcholinesterase inhibitor on single photon emission computed tomography (SPECT) before and after treatment. Rivastigmine 83-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 17142036-6 2007 The leaching rate of the enzyme AChE from the 30 nm polymer beads was found to be 1.1 times higher than that from the 10nm beads. Polymers 52-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 17359933-7 2007 The peripheral anionic site (PAS) is encoded by invariant exons and represents the domain involved in non-cholinergic functions of AChE. Aminosalicylic Acid 29-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 17359933-8 2007 Masking of PAS with fasciculin results in a significant decrease of neurite outgrowth in all clones overexpressing AChE. Aminosalicylic Acid 11-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 17359933-13 2007 Our results indicate that PAS could directly or indirectly mediate AChE/fibronectin interactions. Aminosalicylic Acid 26-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 17504181-3 2007 Oximes hydrolytically cleave the organophosphates from acetylcholinesterase (AChE), restoring enzymatic function. Oximes 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 17504181-3 2007 Oximes hydrolytically cleave the organophosphates from acetylcholinesterase (AChE), restoring enzymatic function. Oximes 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 17504181-3 2007 Oximes hydrolytically cleave the organophosphates from acetylcholinesterase (AChE), restoring enzymatic function. Organophosphates 33-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 17504181-3 2007 Oximes hydrolytically cleave the organophosphates from acetylcholinesterase (AChE), restoring enzymatic function. Organophosphates 33-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 17504181-9 2007 An universality of oximes able to reactivate AChE inhibited by all OP is questioned and trends (molecular modelling using neural network, structure-activity relationship, combination of reactivation and anticholinergic properties in one molecule) for future research are characterized. Oximes 19-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 17492522-10 2007 DISCUSSION: Acetylcholinesterase inhibition by pyridostigmine seems to enhance ganglionic sympathetic transmission and consequently leads to an increase in peripheral resistances that resulted in blood pressure, above all in the upright position. Pyridostigmine Bromide 47-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 17321052-4 2007 Cultures were exposed to CPO (0.1-10 microM) in cell culture medium for 1-7 days, a regimen producing progressive reductions in AChE activity of 15-60%. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 25-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 17335779-0 2007 Calcium-activated butyrylcholinesterase in human skin protects acetylcholinesterase against suicide inhibition by neurotoxic organophosphates. Organophosphates 125-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 17335779-5 2007 Considering the large size of the human skin with 1.8m(2) surface area with its calcium gradient in the 10(-3)M range, our results implicate calcium-activated BuchE as a major protective mechanism against suicide inhibition of AchE by organophosphates in this non-neuronal tissue. Calcium 141-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 227-231 17335779-5 2007 Considering the large size of the human skin with 1.8m(2) surface area with its calcium gradient in the 10(-3)M range, our results implicate calcium-activated BuchE as a major protective mechanism against suicide inhibition of AchE by organophosphates in this non-neuronal tissue. Organophosphates 235-251 acetylcholinesterase (Cartwright blood group) Homo sapiens 227-231 16904807-2 2007 Standard treatment with atropine and the established acetylcholinesterase (AChE) reactivators, obidoxime and pralidoxime, is considered to be ineffective with certain nerve agents due to low oxime effectiveness. Obidoxime Chloride 95-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 16904807-2 2007 Standard treatment with atropine and the established acetylcholinesterase (AChE) reactivators, obidoxime and pralidoxime, is considered to be ineffective with certain nerve agents due to low oxime effectiveness. Obidoxime Chloride 95-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 16904807-2 2007 Standard treatment with atropine and the established acetylcholinesterase (AChE) reactivators, obidoxime and pralidoxime, is considered to be ineffective with certain nerve agents due to low oxime effectiveness. pralidoxime 109-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 16904807-2 2007 Standard treatment with atropine and the established acetylcholinesterase (AChE) reactivators, obidoxime and pralidoxime, is considered to be ineffective with certain nerve agents due to low oxime effectiveness. pralidoxime 109-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 16904807-2 2007 Standard treatment with atropine and the established acetylcholinesterase (AChE) reactivators, obidoxime and pralidoxime, is considered to be ineffective with certain nerve agents due to low oxime effectiveness. Oximes 99-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 16904807-2 2007 Standard treatment with atropine and the established acetylcholinesterase (AChE) reactivators, obidoxime and pralidoxime, is considered to be ineffective with certain nerve agents due to low oxime effectiveness. Oximes 99-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 16904807-5 2007 Since reactivation of OP-inhibited AChE is considered to be the main mechanism of action of oximes, human erythrocyte AChE can be exploited to test the efficacy of new oximes. Oximes 92-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 16904807-6 2007 Recently, a dynamic computer model was developed which allows the calculation of AChE activities at different scenarios by combining enzyme kinetics (inhibition, reactivation, aging) with OP toxicokinetics and oxime pharmacokinetics. Oximes 210-215 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 16904807-9 2007 The model presented may serve as a tool for evaluating the impact of carbamate pretreatment on oxime-induced reactivation of inhibited AChE, for defining effective oxime concentrations and for optimizing oxime treatment. Carbamates 69-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 16904807-9 2007 The model presented may serve as a tool for evaluating the impact of carbamate pretreatment on oxime-induced reactivation of inhibited AChE, for defining effective oxime concentrations and for optimizing oxime treatment. Oximes 95-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 16904807-9 2007 The model presented may serve as a tool for evaluating the impact of carbamate pretreatment on oxime-induced reactivation of inhibited AChE, for defining effective oxime concentrations and for optimizing oxime treatment. Oximes 164-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 16904807-9 2007 The model presented may serve as a tool for evaluating the impact of carbamate pretreatment on oxime-induced reactivation of inhibited AChE, for defining effective oxime concentrations and for optimizing oxime treatment. Oximes 164-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 16904808-2 2007 Presently, standard treatment includes administration of an antimuscarinic agent (e.g. atropine) and a reactivator of inhibited AChE (oxime), but is considered to be rather ineffective with certain nerve agents due to low oxime effectiveness of the currently available oximes, obidoxime and pralidoxime. Oximes 134-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 16904808-5 2007 A dynamic in vitro model, which allows the calculation of AChE activities at different scenarios was developed to facilitate the definition of effective oxime concentrations and the optimization of oxime treatment of OP poisoning of humans and may furthermore be helpful by designing animal experiments. Oximes 153-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 16904808-5 2007 A dynamic in vitro model, which allows the calculation of AChE activities at different scenarios was developed to facilitate the definition of effective oxime concentrations and the optimization of oxime treatment of OP poisoning of humans and may furthermore be helpful by designing animal experiments. Oximes 198-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 16904808-6 2007 The model is based on a combination of enzyme kinetics (inhibition, reactivation, aging) of AChE with OP, toxicokinetics and oxime pharmacokinetics. Oximes 125-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 16904809-2 2007 OP inhibit acetylcholinesterase (AChE) and therefore standard treatment of respective poisoning includes AChE reactivators (oximes) in combination with antimuscarinic agents. Oximes 124-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 16904809-5 2007 Recently, we studied the reactivating potency of several oximes with human AChE inhibited by structurally different OP and observed remarkable differences depending on the OP and oxime. Oximes 57-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 16904809-5 2007 Recently, we studied the reactivating potency of several oximes with human AChE inhibited by structurally different OP and observed remarkable differences depending on the OP and oxime. Oximes 57-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 16904809-10 2007 In contrast, no structure-activity dependence could be observed for the oxime-induced reactivation of AChE and BChE inhibited by the compounds tested. Oximes 72-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 16904809-11 2007 In general, OP-inhibited AChE and BChE were susceptible towards reactivation by oximes. Oximes 80-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 16962227-0 2007 Evaluation of monoquaternary pyridinium oximes potency to reactivate tabun-inhibited human acetylcholinesterase. pyridinium oximes 29-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 16962227-1 2007 Monoquaternary N-benzyl-4-hydroxyiminomethylpyridinium bromide (Py-4-H) and its analogous with diverse substituents introduced into the phenyl ring (Py-4-CH(3), Py-4-Br, Py-4-Cl and Py-4-NO(2)) were synthesized in order to examine their potency as reactivators of tabun-inhibited human erythrocyte acetylcholinesterase (AChE; EC 3.1.1.7). n-benzyl-4-hydroxyiminomethylpyridinium bromide 15-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 298-318 16962227-1 2007 Monoquaternary N-benzyl-4-hydroxyiminomethylpyridinium bromide (Py-4-H) and its analogous with diverse substituents introduced into the phenyl ring (Py-4-CH(3), Py-4-Br, Py-4-Cl and Py-4-NO(2)) were synthesized in order to examine their potency as reactivators of tabun-inhibited human erythrocyte acetylcholinesterase (AChE; EC 3.1.1.7). n-benzyl-4-hydroxyiminomethylpyridinium bromide 15-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 320-324 16962227-1 2007 Monoquaternary N-benzyl-4-hydroxyiminomethylpyridinium bromide (Py-4-H) and its analogous with diverse substituents introduced into the phenyl ring (Py-4-CH(3), Py-4-Br, Py-4-Cl and Py-4-NO(2)) were synthesized in order to examine their potency as reactivators of tabun-inhibited human erythrocyte acetylcholinesterase (AChE; EC 3.1.1.7). py-4-h 64-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 298-318 16962227-1 2007 Monoquaternary N-benzyl-4-hydroxyiminomethylpyridinium bromide (Py-4-H) and its analogous with diverse substituents introduced into the phenyl ring (Py-4-CH(3), Py-4-Br, Py-4-Cl and Py-4-NO(2)) were synthesized in order to examine their potency as reactivators of tabun-inhibited human erythrocyte acetylcholinesterase (AChE; EC 3.1.1.7). py-4-h 64-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 320-324 16962227-1 2007 Monoquaternary N-benzyl-4-hydroxyiminomethylpyridinium bromide (Py-4-H) and its analogous with diverse substituents introduced into the phenyl ring (Py-4-CH(3), Py-4-Br, Py-4-Cl and Py-4-NO(2)) were synthesized in order to examine their potency as reactivators of tabun-inhibited human erythrocyte acetylcholinesterase (AChE; EC 3.1.1.7). py-4-ch 149-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 298-318 16962227-1 2007 Monoquaternary N-benzyl-4-hydroxyiminomethylpyridinium bromide (Py-4-H) and its analogous with diverse substituents introduced into the phenyl ring (Py-4-CH(3), Py-4-Br, Py-4-Cl and Py-4-NO(2)) were synthesized in order to examine their potency as reactivators of tabun-inhibited human erythrocyte acetylcholinesterase (AChE; EC 3.1.1.7). py-4-ch 149-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 320-324 16962227-2 2007 Within 24h, the reactivation of tabun-inhibited AChE reached 80% with Py-4-CH(3), Py-4-Br and Py-4-Cl, 40% with Py-4-NO(2), and 30% with Py-4-H. py-4-ch 70-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 16962227-2 2007 Within 24h, the reactivation of tabun-inhibited AChE reached 80% with Py-4-CH(3), Py-4-Br and Py-4-Cl, 40% with Py-4-NO(2), and 30% with Py-4-H. py-4-br 82-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 16962227-2 2007 Within 24h, the reactivation of tabun-inhibited AChE reached 80% with Py-4-CH(3), Py-4-Br and Py-4-Cl, 40% with Py-4-NO(2), and 30% with Py-4-H. py-4-cl 94-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 16962227-2 2007 Within 24h, the reactivation of tabun-inhibited AChE reached 80% with Py-4-CH(3), Py-4-Br and Py-4-Cl, 40% with Py-4-NO(2), and 30% with Py-4-H. py-4-no 112-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 16962227-2 2007 Within 24h, the reactivation of tabun-inhibited AChE reached 80% with Py-4-CH(3), Py-4-Br and Py-4-Cl, 40% with Py-4-NO(2), and 30% with Py-4-H. py-4-h 137-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 16962227-4 2007 All oximes inhibited human AChE reversibly, and the inhibition potency increased in the following order Py-4-Br<Py-4-Cl<Py-4-CH(3)<Py-4-H<Py-4-NO(2). Oximes 4-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 16962227-4 2007 All oximes inhibited human AChE reversibly, and the inhibition potency increased in the following order Py-4-Br<Py-4-Cl<Py-4-CH(3)<Py-4-H<Py-4-NO(2). py-4-br 104-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 16962227-4 2007 All oximes inhibited human AChE reversibly, and the inhibition potency increased in the following order Py-4-Br<Py-4-Cl<Py-4-CH(3)<Py-4-H<Py-4-NO(2). py-4-cl 115-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 16962227-4 2007 All oximes inhibited human AChE reversibly, and the inhibition potency increased in the following order Py-4-Br<Py-4-Cl<Py-4-CH(3)<Py-4-H<Py-4-NO(2). py-4-ch 126-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 16962227-5 2007 Although oximes Py-4-H and Py-4-NO(2) did not show significant reactivation ability, these oximes might be of interest as pre-treatment drugs due to their high affinity for the native AChE. Oximes 91-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-188 16962227-7 2007 The orientations of all studied oximes in the active site of human AChE have been proposed by flexible ligand docking with AutoDock 3.0. Oximes 32-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 16962227-9 2007 Final docked energies predicted correctly the relative order of the inhibition potency of compounds (except in the case of Py-4-CH(3)) as well as the most probable orientation of the best reactivator, Py-4-Br, which can result in an attack on the phosphorus atom of the tabun-phosphorylated human AChE. py-4-br 201-208 acetylcholinesterase (Cartwright blood group) Homo sapiens 297-301 16962227-9 2007 Final docked energies predicted correctly the relative order of the inhibition potency of compounds (except in the case of Py-4-CH(3)) as well as the most probable orientation of the best reactivator, Py-4-Br, which can result in an attack on the phosphorus atom of the tabun-phosphorylated human AChE. Phosphorus 247-257 acetylcholinesterase (Cartwright blood group) Homo sapiens 297-301 17010492-1 2007 According to current knowledge, inhibition of acetylcholinesterase (AChE) is a very important toxic action of organphosphorus compounds (OP). organphosphorus compounds 110-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 17010492-1 2007 According to current knowledge, inhibition of acetylcholinesterase (AChE) is a very important toxic action of organphosphorus compounds (OP). organphosphorus compounds 110-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 17010492-10 2007 This oxime concentration reactivated RBC-AChE>20% of normal in most cases of OP poisoning by diethylphosphoryl compounds within a few hours. Oximes 5-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 17010492-10 2007 This oxime concentration reactivated RBC-AChE>20% of normal in most cases of OP poisoning by diethylphosphoryl compounds within a few hours. diethylphosphoryl compounds 96-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 17030394-2 2007 Organophosphate compounds produce excessive cholinergic overstimulation in the CNS via blocking acetylcholinesterase activity. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 17045722-0 2007 Polyethylene-glycol conjugated recombinant human acetylcholinesterase serves as an efficacious bioscavenger against soman intoxication. Polyethylene Glycols 0-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 17097792-0 2007 Reversible inhibition of acetylcholinesterase by carbamates or huperzine A increases residual activity of the enzyme upon soman challenge. Carbamates 49-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 17097792-0 2007 Reversible inhibition of acetylcholinesterase by carbamates or huperzine A increases residual activity of the enzyme upon soman challenge. huperzine A 63-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 17097792-6 2007 In previous experiments with carbamate pre-treatment and paraoxon challenge we noticed an increased residual activity of erythrocyte acetylcholinesterase compared to non-pre-treatment. Carbamates 29-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 17097792-6 2007 In previous experiments with carbamate pre-treatment and paraoxon challenge we noticed an increased residual activity of erythrocyte acetylcholinesterase compared to non-pre-treatment. Paraoxon 57-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 17097792-8 2007 Immobilized human erythrocytes were continuously perfused for real-time measurement of acetylcholinesterase activity by a modified Ellman method using 0.45mM acetylthiocholine. Acetylthiocholine 158-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 17129656-14 2007 The bimolecular rate constant k(i) for human AChE inhibition by the isolated P(-) isomer of CMP-MeCyC is five-fold larger than that of its P(+) isomer. cmp-mecyc 92-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 17196318-2 2007 We discuss here how acetylcholinesterase (AChE), through appropriate mutations, becomes more susceptible to oxime reactivation. Oximes 108-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 17196318-2 2007 We discuss here how acetylcholinesterase (AChE), through appropriate mutations, becomes more susceptible to oxime reactivation. Oximes 108-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 17196318-4 2007 Accordingly, "Oxime-assisted Catalysis" by AChE provides a potential means for catalyzing the hydrolysis of organophosphates in plasma prior to their reaching the cellular target site. Oximes 14-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 17196318-4 2007 Accordingly, "Oxime-assisted Catalysis" by AChE provides a potential means for catalyzing the hydrolysis of organophosphates in plasma prior to their reaching the cellular target site. Organophosphates 108-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 17196318-5 2007 In turn, AChE, when conjugated with organophosphate, is employed as a template for "click-chemistry, freeze-frame" synthesis of new nucleophilic reactivating agents that could potentially prove useful in AChE reactivation at the target site as well as in catalytic scavenging of organophosphates in plasma. Organophosphates 36-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 17196318-5 2007 In turn, AChE, when conjugated with organophosphate, is employed as a template for "click-chemistry, freeze-frame" synthesis of new nucleophilic reactivating agents that could potentially prove useful in AChE reactivation at the target site as well as in catalytic scavenging of organophosphates in plasma. Organophosphates 36-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-208 17196318-5 2007 In turn, AChE, when conjugated with organophosphate, is employed as a template for "click-chemistry, freeze-frame" synthesis of new nucleophilic reactivating agents that could potentially prove useful in AChE reactivation at the target site as well as in catalytic scavenging of organophosphates in plasma. Organophosphates 279-295 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 17196318-5 2007 In turn, AChE, when conjugated with organophosphate, is employed as a template for "click-chemistry, freeze-frame" synthesis of new nucleophilic reactivating agents that could potentially prove useful in AChE reactivation at the target site as well as in catalytic scavenging of organophosphates in plasma. Organophosphates 279-295 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-208 17196318-6 2007 Finally, substituted AChE molecules can be conjugated to fluorophores giving rise to shifts in emission spectra for detection of dispersed organophosphates. Organophosphates 139-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 17317172-0 2007 Methyl 2-(2-(4-formylphenoxy)acetamido)-2-substituted acetate derivatives: a new class of acetylcholinesterase inhibitors. methyl 2-(2-(4-formylphenoxy)acetamido)-2-substituted acetate 0-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 17317172-1 2007 A new class of inhibitors of acetylcholinesterase (methyl 2-(2-(4-formylphenoxy)acetamido)-2-substituted acetate derivatives) is described. methyl 2-(2-(4-formylphenoxy)acetamido)-2-substituted acetate 51-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 17208293-2 2007 In this work, the catalytic activity of acetylcholinesterase (AChE) immobilized on these materials was investigated, using neostigmina as AChE inhibitor. neostigmina 123-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 17208293-2 2007 In this work, the catalytic activity of acetylcholinesterase (AChE) immobilized on these materials was investigated, using neostigmina as AChE inhibitor. neostigmina 123-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 17208293-2 2007 In this work, the catalytic activity of acetylcholinesterase (AChE) immobilized on these materials was investigated, using neostigmina as AChE inhibitor. neostigmina 123-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 17208293-5 2007 Therefore, FSM-16-TIPB was the best material, considering also that when neostigmine was applied to AChE immobilized on FSM-16-TIPB, the activity of AChE decreased as occurs in its free from. Neostigmine 73-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 17208293-5 2007 Therefore, FSM-16-TIPB was the best material, considering also that when neostigmine was applied to AChE immobilized on FSM-16-TIPB, the activity of AChE decreased as occurs in its free from. Neostigmine 73-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 17300287-1 2007 Itopride, a dopamine D2 antagonist and acetylcholinesterase inhibitor, significantly improved symptoms in patients with functional dyspepsia in one phase II randomized trial. itopride 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-59 17374745-2 2007 Centrally acting selective muscarinic receptor agonists are currently not available for clinical use, but acetylcholinesterase (AChE) inhibitors, which indirectly stimulate AChR by blocking the breakdown of acetylcholine by AChE, are widely used in the clinic against Alzheimer"s disease. Acetylcholine 106-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 224-228 17374745-5 2007 We wanted to investigate the antipsychotic potential of the AChE inhibitor galantamine, which also allosterically potentiates nicotinic receptor stimulation. Galantamine 75-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 17320203-0 2007 Calcineurin mediates acetylcholinesterase expression during calcium ionophore A23187-induced HeLa cell apoptosis. Calcium 60-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 17320203-0 2007 Calcineurin mediates acetylcholinesterase expression during calcium ionophore A23187-induced HeLa cell apoptosis. Calcimycin 78-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 17320203-3 2007 The calpain inhibitor, calpeptin, and the calcineurin inhibitors, FK506 and cyclosporine A, inhibited acetylcholinesterase expression at both mRNA and protein levels and suppressed the activity of the human acetylcholinesterase promoter. Tacrolimus 66-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 17320203-3 2007 The calpain inhibitor, calpeptin, and the calcineurin inhibitors, FK506 and cyclosporine A, inhibited acetylcholinesterase expression at both mRNA and protein levels and suppressed the activity of the human acetylcholinesterase promoter. Tacrolimus 66-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-227 17320203-3 2007 The calpain inhibitor, calpeptin, and the calcineurin inhibitors, FK506 and cyclosporine A, inhibited acetylcholinesterase expression at both mRNA and protein levels and suppressed the activity of the human acetylcholinesterase promoter. Cyclosporine 76-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 17320203-3 2007 The calpain inhibitor, calpeptin, and the calcineurin inhibitors, FK506 and cyclosporine A, inhibited acetylcholinesterase expression at both mRNA and protein levels and suppressed the activity of the human acetylcholinesterase promoter. Cyclosporine 76-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-227 17320203-6 2007 Overexpression of human NFATc3 and NFATc4 greatly increased the acetylcholinesterase promoter activity in HeLa cells treated with A23187. Calcimycin 130-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 17005066-1 2007 BACKGROUND: There is general consensus regarding the benefit of acetylcholinesterase inhibitors (e.g. donepezil) in Alzheimer"s disease (AD). Donepezil 102-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 17346955-1 2007 Inhibition of acetylcholinesterase (AChE), the key enzyme in the breakdown of acetylcholine, is considered as a promising strategy for the treatment of neurological disorders such as Alzheimer"s disease, senile dementia, ataxia and myasthenia gravis. Acetylcholine 14-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 17303332-2 2007 Alterations of cortical excitability, induced by acute and repeated administration of the acetylcholinesterase inhibitor rivastigmine were investigated with transcranial magnetic stimulation in healthy volunteers. Rivastigmine 121-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 16905305-2 2007 When an inhibition study with the developed sensor was undertaken at the optimized AChE immobilization with varying concentrations of a model organophosphorus pesticide EPN and carbamate one carbofuran, a sensitive detection for them was possible with the limit of detection corresponding to 1.55 x 10(-8) and 1.30 x 10(-9)M, respectively. organophosphorus 142-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 16905305-2 2007 When an inhibition study with the developed sensor was undertaken at the optimized AChE immobilization with varying concentrations of a model organophosphorus pesticide EPN and carbamate one carbofuran, a sensitive detection for them was possible with the limit of detection corresponding to 1.55 x 10(-8) and 1.30 x 10(-9)M, respectively. Carbamates 177-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 16905305-2 2007 When an inhibition study with the developed sensor was undertaken at the optimized AChE immobilization with varying concentrations of a model organophosphorus pesticide EPN and carbamate one carbofuran, a sensitive detection for them was possible with the limit of detection corresponding to 1.55 x 10(-8) and 1.30 x 10(-9)M, respectively. Carbofuran 191-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 17134713-2 2007 For this application, human recombinant AChE was covalently immobilized onto an ethylenediamine (EDA) monolithic Convective Interaction Media (CIM) disk and on-line studies were performed by inserting this IMER into a HPLC system. ethylenediamine 80-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 17134713-2 2007 For this application, human recombinant AChE was covalently immobilized onto an ethylenediamine (EDA) monolithic Convective Interaction Media (CIM) disk and on-line studies were performed by inserting this IMER into a HPLC system. ethylenediamine 97-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 17134713-2 2007 For this application, human recombinant AChE was covalently immobilized onto an ethylenediamine (EDA) monolithic Convective Interaction Media (CIM) disk and on-line studies were performed by inserting this IMER into a HPLC system. cim 143-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 17134713-3 2007 Short analysis time, absence of backpressure, low nonspecific matrix interactions and immediate recovery of enzyme activity were the best characteristics of this AChE-CIM-IMER. cim 167-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-166 17134713-7 2007 Moreover, noteworthy results were obtained in the application of the AChE-CIM-IMER to the characterization of the carbamoylation and decarbamoylation steps in pseudo-irreversible binding of carbamate derivatives (physostigmine and rivastigmine). cim 74-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 17134713-7 2007 Moreover, noteworthy results were obtained in the application of the AChE-CIM-IMER to the characterization of the carbamoylation and decarbamoylation steps in pseudo-irreversible binding of carbamate derivatives (physostigmine and rivastigmine). Carbamates 190-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 17134713-7 2007 Moreover, noteworthy results were obtained in the application of the AChE-CIM-IMER to the characterization of the carbamoylation and decarbamoylation steps in pseudo-irreversible binding of carbamate derivatives (physostigmine and rivastigmine). Physostigmine 213-226 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 17134713-7 2007 Moreover, noteworthy results were obtained in the application of the AChE-CIM-IMER to the characterization of the carbamoylation and decarbamoylation steps in pseudo-irreversible binding of carbamate derivatives (physostigmine and rivastigmine). Rivastigmine 231-243 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 17134713-10 2007 Furthermore, after inactivation by carbamates, activity could be fully recovered and the AChE-CIM-IMER could be reused for further studies. Carbamates 35-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 17134713-10 2007 Furthermore, after inactivation by carbamates, activity could be fully recovered and the AChE-CIM-IMER could be reused for further studies. cim 94-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 17298091-0 2007 Oxime-induced reactivation of sarin-inhibited AChE: a theoretical mechanisms study. Oximes 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 17298091-1 2007 Oximes (especially oximate anions) are used as potential reactivators of OP-inhibited AChE due to their unique alpha-effect nucleophilic reactivity. oximes 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 17298091-2 2007 In the present study, by applying the DFT approach at the B3LYP/6-311G(d,p) level and the Moller-Plesset perturbation theory at the MP2/6-311G(d,p) level, the formoximate-induced reactivation patterns of the sarin-AChE adduct and the corresponding reaction mechanism have been investigated. formoximate 159-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-218 17298091-3 2007 The potential energy surface along the pathway of the reactivation reaction of sarin-inhibited AChE by oxime reveals that the reaction can occur quickly due to the relatively low energy barriers. Oximes 103-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 17298091-5 2007 Through the nucleophilic attack, the oximate first binds to the sarin-AChE adduct to form a relatively stable phosphorus complex. Phosphorus 110-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 17298091-9 2007 The results derived from both the gas-phase model and the aqueous solvation model suggest that the studied oximate anion is an efficient antidote reagent for sarin-inhibited AChE. oximate anion 107-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 17590134-1 2007 Acute organophosphate poisoning leads to a cholinergic crisis secondary to an acetylcholine rise, developed by an acetylcholinesterase inhibition. Organophosphates 6-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 17590134-1 2007 Acute organophosphate poisoning leads to a cholinergic crisis secondary to an acetylcholine rise, developed by an acetylcholinesterase inhibition. Acetylcholine 78-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 17242930-1 2007 A new method for immobilization of acetylcholinesterase (AChE) to alginate gel beads by activating the carbonyl groups of alginate using carbodiimide coupling agent has been successfully developed. Alginates 66-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 17242930-1 2007 A new method for immobilization of acetylcholinesterase (AChE) to alginate gel beads by activating the carbonyl groups of alginate using carbodiimide coupling agent has been successfully developed. Alginates 66-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 17242930-1 2007 A new method for immobilization of acetylcholinesterase (AChE) to alginate gel beads by activating the carbonyl groups of alginate using carbodiimide coupling agent has been successfully developed. Alginates 122-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 17242930-1 2007 A new method for immobilization of acetylcholinesterase (AChE) to alginate gel beads by activating the carbonyl groups of alginate using carbodiimide coupling agent has been successfully developed. Alginates 122-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 17242930-1 2007 A new method for immobilization of acetylcholinesterase (AChE) to alginate gel beads by activating the carbonyl groups of alginate using carbodiimide coupling agent has been successfully developed. Carbodiimides 137-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 17242930-1 2007 A new method for immobilization of acetylcholinesterase (AChE) to alginate gel beads by activating the carbonyl groups of alginate using carbodiimide coupling agent has been successfully developed. Carbodiimides 137-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 17323978-3 2007 However, recent evidence has shown that acetylcholinesterase (AChE) and the catalytic domain of human neuropathy target esterase (NEST) undergo aging by alternative mechanisms following their inhibition with N,N"-diisopropylphosphorodiamidofluoridate (mipafox, MIP). n,n"-diisopropylphosphorodiamidofluoridate 208-250 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 17323978-3 2007 However, recent evidence has shown that acetylcholinesterase (AChE) and the catalytic domain of human neuropathy target esterase (NEST) undergo aging by alternative mechanisms following their inhibition with N,N"-diisopropylphosphorodiamidofluoridate (mipafox, MIP). n,n"-diisopropylphosphorodiamidofluoridate 208-250 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 17323978-3 2007 However, recent evidence has shown that acetylcholinesterase (AChE) and the catalytic domain of human neuropathy target esterase (NEST) undergo aging by alternative mechanisms following their inhibition with N,N"-diisopropylphosphorodiamidofluoridate (mipafox, MIP). mipafox 252-259 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 17323978-3 2007 However, recent evidence has shown that acetylcholinesterase (AChE) and the catalytic domain of human neuropathy target esterase (NEST) undergo aging by alternative mechanisms following their inhibition with N,N"-diisopropylphosphorodiamidofluoridate (mipafox, MIP). mipafox 252-259 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 17456837-2 2007 Organophosphorus compounds share a common mode of action, exerting their toxic effects primarily via acetylcholinesterase (AChE) inhibition. Organophosphorus Compounds 0-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 17456837-2 2007 Organophosphorus compounds share a common mode of action, exerting their toxic effects primarily via acetylcholinesterase (AChE) inhibition. Organophosphorus Compounds 0-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 17456837-6 2007 Oximes, as a part of antidotal therapy, ensure the recovery of phosphylated enzymes via a process denoted as reactivation of inhibited AChE. Oximes 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 17456837-10 2007 TMB-4 and LuH-6 may reactivate tabun-inhibited AChE, whereas HI-6 possesses the ability to reactivate the soman-inhibited enzyme. Trimedoxime 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 17456837-10 2007 TMB-4 and LuH-6 may reactivate tabun-inhibited AChE, whereas HI-6 possesses the ability to reactivate the soman-inhibited enzyme. luh-6 10-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 17456837-11 2007 An oxime HLo-7 seems to be an efficient reactivator of AChE inhibited by any of the four organophosphorus warfare agents. Oximes 3-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 17456837-11 2007 An oxime HLo-7 seems to be an efficient reactivator of AChE inhibited by any of the four organophosphorus warfare agents. HLo 7 9-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 17456837-11 2007 An oxime HLo-7 seems to be an efficient reactivator of AChE inhibited by any of the four organophosphorus warfare agents. organophosphorus 89-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 17456837-12 2007 According to the available literature, the oximes LuH-6 and TMB-4, although relatively toxic, are the most potent to induce reactivation of AChE inhibited by the majority of organophosphorus pesticides. Oximes 43-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 17456837-12 2007 According to the available literature, the oximes LuH-6 and TMB-4, although relatively toxic, are the most potent to induce reactivation of AChE inhibited by the majority of organophosphorus pesticides. luh-6 50-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 17456837-12 2007 According to the available literature, the oximes LuH-6 and TMB-4, although relatively toxic, are the most potent to induce reactivation of AChE inhibited by the majority of organophosphorus pesticides. Trimedoxime 60-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 17456837-12 2007 According to the available literature, the oximes LuH-6 and TMB-4, although relatively toxic, are the most potent to induce reactivation of AChE inhibited by the majority of organophosphorus pesticides. organophosphorus 174-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 17355738-2 2007 Acetylcholinesterase (AChE) inhibitors, such as rivastigmine, have been shown to improve cognition in other disorders, particularly Alzheimer"s disease. Rivastigmine 48-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 17355738-2 2007 Acetylcholinesterase (AChE) inhibitors, such as rivastigmine, have been shown to improve cognition in other disorders, particularly Alzheimer"s disease. Rivastigmine 48-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 17675917-0 2007 [Effects of the association of sulbutiamine with an acetylcholinesterase inhibitor in early stage and moderate Alzheimer disease]. sulbutiamine 31-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 17265452-0 2007 In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxon. Oximes 9-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 17265452-0 2007 In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxon. methylparaoxon 80-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 17174965-1 2007 Relocation of a glycosylphosphatidylinositol (GPI)-anchored protein acetylcholinesterase (AChE) in its enzymatically active form from proteovesicles containing human erythrocyte ghost membrane proteins onto a liposome-gel conjugate was examined. Glycosylphosphatidylinositols 16-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 17174965-1 2007 Relocation of a glycosylphosphatidylinositol (GPI)-anchored protein acetylcholinesterase (AChE) in its enzymatically active form from proteovesicles containing human erythrocyte ghost membrane proteins onto a liposome-gel conjugate was examined. Glycosylphosphatidylinositols 16-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 17174965-1 2007 Relocation of a glycosylphosphatidylinositol (GPI)-anchored protein acetylcholinesterase (AChE) in its enzymatically active form from proteovesicles containing human erythrocyte ghost membrane proteins onto a liposome-gel conjugate was examined. Glycosylphosphatidylinositols 46-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 17174965-1 2007 Relocation of a glycosylphosphatidylinositol (GPI)-anchored protein acetylcholinesterase (AChE) in its enzymatically active form from proteovesicles containing human erythrocyte ghost membrane proteins onto a liposome-gel conjugate was examined. Glycosylphosphatidylinositols 46-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 17158047-0 2007 Quantitative structure-activity relationship (QSAR) of tacrine derivatives against acetylcholinesterase (AChE) activity using variable selections. Tacrine 55-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 16971898-0 2007 Scopolamine induces disruption of latent inhibition which is prevented by antipsychotic drugs and an acetylcholinesterase inhibitor. Scopolamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 16971898-4 2007 Here, we tested whether the muscarinic antagonist scopolamine would disrupt LI and whether such disruption would be reversed by APDs and by the acetylcholinesterase inhibitor physostigmine. Physostigmine 175-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-164 17112559-3 2007 Reactivators (oximes) of inhibited AChE are a mainstay of treatment, however, the commercially available compounds, obidoxime and pralidoxime, are considered to be rather ineffective against various nerve agents, e.g. soman and cyclosarin. Oximes 14-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 17112559-3 2007 Reactivators (oximes) of inhibited AChE are a mainstay of treatment, however, the commercially available compounds, obidoxime and pralidoxime, are considered to be rather ineffective against various nerve agents, e.g. soman and cyclosarin. Obidoxime Chloride 116-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 17112559-3 2007 Reactivators (oximes) of inhibited AChE are a mainstay of treatment, however, the commercially available compounds, obidoxime and pralidoxime, are considered to be rather ineffective against various nerve agents, e.g. soman and cyclosarin. cyclohexyl methylphosphonofluoridate 228-238 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 17112559-5 2007 Reactivation of OP-inhibited AChE is considered to be the most important reaction of oximes. Oximes 85-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 17112559-6 2007 Clinical data from studies with pesticide-poisoned patients support the assumption that the various reactions between AChE, OP and oxime, i.e. inhibition, reactivation and aging, can be investigated in vitro with human AChE. Oximes 131-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 219-223 17188496-0 2007 Carinatumins A-C, new alkaloids from Lycopodium carinatum inhibiting acetylcholinesterase. carinatumins a-c 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 17188496-0 2007 Carinatumins A-C, new alkaloids from Lycopodium carinatum inhibiting acetylcholinesterase. Alkaloids 22-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 17188496-3 2007 Carinatumins A (1) and B (2) exhibited a potent inhibitory activity against acetylcholinesterase. carinatumin A 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 17188496-3 2007 Carinatumins A (1) and B (2) exhibited a potent inhibitory activity against acetylcholinesterase. and b 19-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 17158047-0 2007 Quantitative structure-activity relationship (QSAR) of tacrine derivatives against acetylcholinesterase (AChE) activity using variable selections. Tacrine 55-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 17158047-1 2007 A diverse approach to the quantitative structure-activity relationship (QSAR) of tacrine derivatives against acetylcholinesterase (AChE) activity was studied using variable selections of stepwise multiple linear regression (MLR), genetic algorithm (GA)-MLR, and simulated annealing (SA)-MLR. Tacrine 81-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-129 17158047-1 2007 A diverse approach to the quantitative structure-activity relationship (QSAR) of tacrine derivatives against acetylcholinesterase (AChE) activity was studied using variable selections of stepwise multiple linear regression (MLR), genetic algorithm (GA)-MLR, and simulated annealing (SA)-MLR. Tacrine 81-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 17158047-2 2007 AChE activity (logRA) of tacrine derivatives was expressed with acceptable explanation (95.5-95.9%) and good predictive power (94.5-95.2%), respectively, in the models. Tacrine 25-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 17158452-0 2007 Assembly of acetylcholinesterase tetramers by peptidic motifs from the proline-rich membrane anchor, PRiMA: competition between degradation and secretion pathways of heteromeric complexes. Proline 71-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 17158452-6 2007 We confirmed the importance of the polyproline stretches and defined a peptidic motif (RP4LP10RL), which induces the assembly and secretion of a heteromeric complex with four AChE(T) subunits, nearly as efficiently as the entire extracellular domain of PRiMA. polyproline 35-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 175-179 17158452-8 2007 Interestingly, short PRiMA mutants, truncated within the proline-rich motif, reduced both cellular and secreted AChE activity, suggesting that their interaction with AChE(T) subunits induces their intracellular degradation. Proline 57-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 17158452-8 2007 Interestingly, short PRiMA mutants, truncated within the proline-rich motif, reduced both cellular and secreted AChE activity, suggesting that their interaction with AChE(T) subunits induces their intracellular degradation. Proline 57-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 17186224-0 2007 An amperometric acetylthiocholine sensor based on immobilization of acetylcholinesterase on a multiwall carbon nanotube-cross-linked chitosan composite. Acetylthiocholine 16-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 17186224-0 2007 An amperometric acetylthiocholine sensor based on immobilization of acetylcholinesterase on a multiwall carbon nanotube-cross-linked chitosan composite. Carbon 104-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 17186224-1 2007 A simple method has been devised for immobilization of acetylcholinesterase (AChE)--covalent bonding to a multiwall carbon nanotube (MWNT)--cross-linked chitosan composite (CMC)-and a sensitive amperometric sensor for rapid detection of acetylthiocholine (ATCl) has been based on this. Carbon 116-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 17186224-1 2007 A simple method has been devised for immobilization of acetylcholinesterase (AChE)--covalent bonding to a multiwall carbon nanotube (MWNT)--cross-linked chitosan composite (CMC)-and a sensitive amperometric sensor for rapid detection of acetylthiocholine (ATCl) has been based on this. Carbon 116-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 17186224-1 2007 A simple method has been devised for immobilization of acetylcholinesterase (AChE)--covalent bonding to a multiwall carbon nanotube (MWNT)--cross-linked chitosan composite (CMC)-and a sensitive amperometric sensor for rapid detection of acetylthiocholine (ATCl) has been based on this. Acetylthiocholine 237-254 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 17186224-1 2007 A simple method has been devised for immobilization of acetylcholinesterase (AChE)--covalent bonding to a multiwall carbon nanotube (MWNT)--cross-linked chitosan composite (CMC)-and a sensitive amperometric sensor for rapid detection of acetylthiocholine (ATCl) has been based on this. Acetylthiocholine 237-254 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 17186224-1 2007 A simple method has been devised for immobilization of acetylcholinesterase (AChE)--covalent bonding to a multiwall carbon nanotube (MWNT)--cross-linked chitosan composite (CMC)-and a sensitive amperometric sensor for rapid detection of acetylthiocholine (ATCl) has been based on this. Acetylthiocholine 256-260 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 17186224-1 2007 A simple method has been devised for immobilization of acetylcholinesterase (AChE)--covalent bonding to a multiwall carbon nanotube (MWNT)--cross-linked chitosan composite (CMC)-and a sensitive amperometric sensor for rapid detection of acetylthiocholine (ATCl) has been based on this. Acetylthiocholine 256-260 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 17186224-3 2007 Glutaraldehyde was used as cross-linker to covalently bond the AChE, and efficiently prevented leakage of the enzyme from the film. Glutaral 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 17186224-4 2007 Because of the inherent conductive properties of the MWNT, the immobilized AChE had greater affinity for ATCl and excellent catalytic effect in the hydrolysis of ATCl, with a K(app)(m) value of 132 micromol L(-1), forming thiocholine, which was then oxidized to produce a detectable and rapid response. Acetylthiocholine 105-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 17186224-4 2007 Because of the inherent conductive properties of the MWNT, the immobilized AChE had greater affinity for ATCl and excellent catalytic effect in the hydrolysis of ATCl, with a K(app)(m) value of 132 micromol L(-1), forming thiocholine, which was then oxidized to produce a detectable and rapid response. Acetylthiocholine 162-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 17186224-4 2007 Because of the inherent conductive properties of the MWNT, the immobilized AChE had greater affinity for ATCl and excellent catalytic effect in the hydrolysis of ATCl, with a K(app)(m) value of 132 micromol L(-1), forming thiocholine, which was then oxidized to produce a detectable and rapid response. Thiocholine 222-233 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 16955366-6 2007 Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) are serine hydrolase enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine, a key process in the regulation of the cholinergic system. Acetylcholine 144-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 17126020-0 2007 Study on dual-site inhibitors of acetylcholinesterase: Highly potent derivatives of bis- and bifunctional huperzine B. huperzine B 106-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 17126020-1 2007 Natural (-)-huperzine B (HupB), isolated from Chinese medicinal herb, displayed moderate inhibitory activity of acetylcholinesterase (AChE). huperzine B 8-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 17126020-1 2007 Natural (-)-huperzine B (HupB), isolated from Chinese medicinal herb, displayed moderate inhibitory activity of acetylcholinesterase (AChE). huperzine B 8-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 17126020-4 2007 Among bis-HupB derivatives, 12h exhibited the most potent in the AChE inhibition and has been evaluated for its pharmacological actions in vivo on ChE inhibition, cognitive enhancement, and neuroprotection. 12-hydroxydodecanoic acid 28-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 16955366-6 2007 Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) are serine hydrolase enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine, a key process in the regulation of the cholinergic system. Acetylcholine 144-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 17097717-0 2007 Photodegradation of organophosphorus insecticides - investigations of products and their toxicity using gas chromatography-mass spectrometry and AChE-thermal lens spectrometric bioassay. organophosphorus 20-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 17097717-9 2007 Several other photoproducts including trimethyl phosphate esters, which are known to be AChE inhibitors and 1,2,3-benzotriazin-4(3H)-one as a member of triazine compounds were identified in photodegraded samples of malathion, malaoxon, and azinphos-methyl. trimethyl phosphate esters 38-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 16955366-14 2007 Homocysteine thiolactone, the cyclic metabolite of homocysteine, slowly and irreversibly inhibited the activity of human AChE. Homocysteine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 16955366-14 2007 Homocysteine thiolactone, the cyclic metabolite of homocysteine, slowly and irreversibly inhibited the activity of human AChE. Thiolactone 13-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 16955366-14 2007 Homocysteine thiolactone, the cyclic metabolite of homocysteine, slowly and irreversibly inhibited the activity of human AChE. Homocysteine 51-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 17227232-2 2007 Thus, the aim of many treatment regimens is to support this system either by means of muscarinic agonists or by inhibitors of acetylcholinesterase (AChE), the latter being able to increase the concentration of acetylcholine. Acetylcholine 126-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 17253727-0 2007 Synthesis of fenthion sulfoxide and fenoxon sulfoxide enantiomers: effect of sulfur chirality on acetylcholinesterase activity. Mesulfenfos 13-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 17253727-0 2007 Synthesis of fenthion sulfoxide and fenoxon sulfoxide enantiomers: effect of sulfur chirality on acetylcholinesterase activity. fenoxon sulfoxide 36-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 17253727-9 2007 Although the stereoselective sulfoxidation of fenthion to (R)-(+)-fenthion sulfoxide by FMO represents a detoxification pathway, the results of this study support the notion that subsequent oxidative desulfuration of (R)-(+)-fenthion sulfoxide (in vivo) may represent a critical bioactivation pathway, resulting in the production of (R)-(+)-fenoxon sulfoxide, a potent AChE inhibitor. Fenthion 46-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 369-373 17253727-9 2007 Although the stereoselective sulfoxidation of fenthion to (R)-(+)-fenthion sulfoxide by FMO represents a detoxification pathway, the results of this study support the notion that subsequent oxidative desulfuration of (R)-(+)-fenthion sulfoxide (in vivo) may represent a critical bioactivation pathway, resulting in the production of (R)-(+)-fenoxon sulfoxide, a potent AChE inhibitor. fmo 88-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 369-373 17425139-1 2007 A simple, rapid, sensitive, and selective liquid chromatography-tandem mass spectrometry method is developed and validated for the quantitation of galantamine, an acetylcholinesterase inhibitor in human plasma, using a commercially available compound, loratadine, as the internal standard. Galantamine 147-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-183 17141935-4 2007 Organophosphates block acetylcholinesterase activity, thereby inducing excessive cholinergic overstimulation in the central nervous system. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 17406998-6 2007 The seleno compounds show lower affinities for hAChE relative to the thino compounds. seleno 4-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-52 17085051-0 2007 Preparation of secolycorines against acetylcholinesterase. secolycorines 15-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 17085051-2 2007 Several secolycorine derivatives showed potent inhibitory activity against acetylcholinesterase with the IC(50) value at micromolar range and are more potent than galanthamine. secolycorine 8-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 17085051-2 2007 Several secolycorine derivatives showed potent inhibitory activity against acetylcholinesterase with the IC(50) value at micromolar range and are more potent than galanthamine. Galantamine 163-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 17713603-0 2007 Evaluation of HI-6 oxime: potential use in protection of human acetylcholinesterase inhibited by antineoplastic drug irinotecan and its cyto/genotoxicity in vitro. hi-6 oxime 14-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 17713603-0 2007 Evaluation of HI-6 oxime: potential use in protection of human acetylcholinesterase inhibited by antineoplastic drug irinotecan and its cyto/genotoxicity in vitro. Irinotecan 117-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 17713603-1 2007 The function of acetylcholinesterase (AChE) is the rapid hydrolysis of the neurotransmitter acetylcholine (ACh), which is involved in the numerous cholinergic pathways in both the central and the peripheral nervous system. Acetylcholine 16-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 17713603-1 2007 The function of acetylcholinesterase (AChE) is the rapid hydrolysis of the neurotransmitter acetylcholine (ACh), which is involved in the numerous cholinergic pathways in both the central and the peripheral nervous system. Acetylcholine 38-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 17713603-4 2007 Since their adverse effects are not well elucidated, in this study the efficiency of HI-6 oxime in protection and/or reactivation of human erythrocyte AChE inhibited by the antineoplastic drug irinotecan as well as its cyto/genotoxicity in vitro were investigated. hi-6 oxime 85-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 17713603-4 2007 Since their adverse effects are not well elucidated, in this study the efficiency of HI-6 oxime in protection and/or reactivation of human erythrocyte AChE inhibited by the antineoplastic drug irinotecan as well as its cyto/genotoxicity in vitro were investigated. Irinotecan 193-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 17713603-5 2007 HI-6 was effective in protection of AChE and increased its activity up to 30%; the residual activity after irinotecan inhibition was 7%. asoxime chloride 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 18254274-0 2007 Evaluation of potency of known oximes (pralidoxime, trimedoxime, HI-6, methoxime, obidoxime) to in vitro reactivate acetylcholinesterase inhibited by pesticides (chlorpyrifos and methylchlorpyrifos) and nerve agent (Russian VX). Oximes 31-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 18254274-0 2007 Evaluation of potency of known oximes (pralidoxime, trimedoxime, HI-6, methoxime, obidoxime) to in vitro reactivate acetylcholinesterase inhibited by pesticides (chlorpyrifos and methylchlorpyrifos) and nerve agent (Russian VX). asoxime chloride 65-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 18254274-0 2007 Evaluation of potency of known oximes (pralidoxime, trimedoxime, HI-6, methoxime, obidoxime) to in vitro reactivate acetylcholinesterase inhibited by pesticides (chlorpyrifos and methylchlorpyrifos) and nerve agent (Russian VX). Obidoxime Chloride 82-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 18254274-0 2007 Evaluation of potency of known oximes (pralidoxime, trimedoxime, HI-6, methoxime, obidoxime) to in vitro reactivate acetylcholinesterase inhibited by pesticides (chlorpyrifos and methylchlorpyrifos) and nerve agent (Russian VX). Chlorpyrifos 162-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 18254274-5 2007 In this study, five commonly used AChE reactivators (pralidoxime, methoxime, HI-6, obidoxime, trimedoxime) for the reactivation of AChE inhibited by two pesticides (chlorpyrifos and methylchlorpyrifos) were used. pralidoxime 53-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 18254274-5 2007 In this study, five commonly used AChE reactivators (pralidoxime, methoxime, HI-6, obidoxime, trimedoxime) for the reactivation of AChE inhibited by two pesticides (chlorpyrifos and methylchlorpyrifos) were used. pralidoxime 53-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 18254274-5 2007 In this study, five commonly used AChE reactivators (pralidoxime, methoxime, HI-6, obidoxime, trimedoxime) for the reactivation of AChE inhibited by two pesticides (chlorpyrifos and methylchlorpyrifos) were used. N,N'-monomethylenebis(pyridiniumaldoxime) 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 18254274-5 2007 In this study, five commonly used AChE reactivators (pralidoxime, methoxime, HI-6, obidoxime, trimedoxime) for the reactivation of AChE inhibited by two pesticides (chlorpyrifos and methylchlorpyrifos) were used. N,N'-monomethylenebis(pyridiniumaldoxime) 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 18254274-5 2007 In this study, five commonly used AChE reactivators (pralidoxime, methoxime, HI-6, obidoxime, trimedoxime) for the reactivation of AChE inhibited by two pesticides (chlorpyrifos and methylchlorpyrifos) were used. asoxime chloride 77-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 18254274-5 2007 In this study, five commonly used AChE reactivators (pralidoxime, methoxime, HI-6, obidoxime, trimedoxime) for the reactivation of AChE inhibited by two pesticides (chlorpyrifos and methylchlorpyrifos) were used. asoxime chloride 77-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 18254274-5 2007 In this study, five commonly used AChE reactivators (pralidoxime, methoxime, HI-6, obidoxime, trimedoxime) for the reactivation of AChE inhibited by two pesticides (chlorpyrifos and methylchlorpyrifos) were used. Obidoxime Chloride 83-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 18254274-5 2007 In this study, five commonly used AChE reactivators (pralidoxime, methoxime, HI-6, obidoxime, trimedoxime) for the reactivation of AChE inhibited by two pesticides (chlorpyrifos and methylchlorpyrifos) were used. Obidoxime Chloride 83-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 18254274-5 2007 In this study, five commonly used AChE reactivators (pralidoxime, methoxime, HI-6, obidoxime, trimedoxime) for the reactivation of AChE inhibited by two pesticides (chlorpyrifos and methylchlorpyrifos) were used. Trimedoxime 94-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 18254274-5 2007 In this study, five commonly used AChE reactivators (pralidoxime, methoxime, HI-6, obidoxime, trimedoxime) for the reactivation of AChE inhibited by two pesticides (chlorpyrifos and methylchlorpyrifos) were used. Trimedoxime 94-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 18254274-5 2007 In this study, five commonly used AChE reactivators (pralidoxime, methoxime, HI-6, obidoxime, trimedoxime) for the reactivation of AChE inhibited by two pesticides (chlorpyrifos and methylchlorpyrifos) were used. Chlorpyrifos 165-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 18254274-5 2007 In this study, five commonly used AChE reactivators (pralidoxime, methoxime, HI-6, obidoxime, trimedoxime) for the reactivation of AChE inhibited by two pesticides (chlorpyrifos and methylchlorpyrifos) were used. Chlorpyrifos 165-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 18254274-5 2007 In this study, five commonly used AChE reactivators (pralidoxime, methoxime, HI-6, obidoxime, trimedoxime) for the reactivation of AChE inhibited by two pesticides (chlorpyrifos and methylchlorpyrifos) were used. chlorpyrifos-methyl 182-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 18254274-5 2007 In this study, five commonly used AChE reactivators (pralidoxime, methoxime, HI-6, obidoxime, trimedoxime) for the reactivation of AChE inhibited by two pesticides (chlorpyrifos and methylchlorpyrifos) were used. chlorpyrifos-methyl 182-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 18254274-8 2007 Especially, methylchlorpyrifos-inhibited AChE was found to be poorly reactivated by the compounds used. chlorpyrifos-methyl 12-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 18290547-1 2007 Amperometric biosensor based on enzyme acetylcholinesterase (AChE; EC 3.1.1.7) was tested for pesticide methamidophos assay. methamidophos 104-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 18290547-1 2007 Amperometric biosensor based on enzyme acetylcholinesterase (AChE; EC 3.1.1.7) was tested for pesticide methamidophos assay. methamidophos 104-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 18290547-4 2007 The measuring principle was based on the inhibition of AChE activity in the presence of methamidophos. methamidophos 88-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 17194818-1 2007 OBJECTIVE: The objective of this study was to evaluate donepezil, an acetylcholinesterase inhibitor, in the treatment of frontotemporal dementia (FTD). Donepezil 55-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 17449453-4 2007 As resulted, oxime K074 appears to be the most potent reactivator of tabun-inhibited AChE, with reactivation potency comparable to that of obidoxime. oxime k074 13-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 17181144-0 2006 Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer"s disease. Tacrine 18-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 17181144-0 2006 Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer"s disease. 1,4-dihydropyridine 26-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 17181144-2 2006 These multipotent molecules are the result of the juxtaposition of an acetylcholinesterase inhibitor (AChEI) such as tacrine (1) and a 1,4-DHP such as nimodipine (2). Tacrine 117-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 17005406-4 2006 In addition, the propidium displacement experiments showed that these compounds bind AChE to the peripheral anionic site (PAS) of AChE and, consequently, are potential agents that can prevent the aggregation of beta-amyloid. Propidium 17-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 17005406-4 2006 In addition, the propidium displacement experiments showed that these compounds bind AChE to the peripheral anionic site (PAS) of AChE and, consequently, are potential agents that can prevent the aggregation of beta-amyloid. Propidium 17-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 17005406-4 2006 In addition, the propidium displacement experiments showed that these compounds bind AChE to the peripheral anionic site (PAS) of AChE and, consequently, are potential agents that can prevent the aggregation of beta-amyloid. Aminosalicylic Acid 122-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 17005406-4 2006 In addition, the propidium displacement experiments showed that these compounds bind AChE to the peripheral anionic site (PAS) of AChE and, consequently, are potential agents that can prevent the aggregation of beta-amyloid. Aminosalicylic Acid 122-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 16529923-0 2006 Acetylcholinesterase-ISFET based system for the detection of acetylcholine and acetylcholinesterase inhibitors. Acetylcholine 61-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 17149883-3 2006 The compounds were evaluated as cholinesterase inhibitors, and trimethoxybenzoic acid derivatives with 11- or 12-atom spacers were the most potent inhibitors of human acetylcholinesterase. 2,3,4-TRIMETHOXYBENZOIC ACID 63-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-187 17597908-1 2006 The enzyme acetylcholinesterase (AChE) which belongs to the family of alpha/beta hydrolases is well known for hydrolyzing the neurotransmitter acetylcholine (ACh). Acetylcholine 11-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 17597908-1 2006 The enzyme acetylcholinesterase (AChE) which belongs to the family of alpha/beta hydrolases is well known for hydrolyzing the neurotransmitter acetylcholine (ACh). Acetylcholine 33-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 17454383-0 2007 Acetylcholinesterase-polyaniline biosensor investigation of organophosphate pesticides in selected organic solvents. polyaniline 21-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 17454383-0 2007 Acetylcholinesterase-polyaniline biosensor investigation of organophosphate pesticides in selected organic solvents. Organophosphates 60-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 17454383-1 2007 The behavior of an amperometric organic-phase biosensor consisting of a gold electrode modified first with a mercaptobenzothiazole self-assembled monolayer, followed by electropolymerization of polyaniline in which acetylcholinesterase as enzyme was immobilized, has been developed and evaluated for organophosphorous pesticide detection. polyaniline 194-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 215-235 17454383-2 2007 The voltammetric results have shown that the formal potential shifts anodically as the Au/MBT/PANI/AChE/PVAc thick-film biosensor responded to acetylthiocholine substrate addition under anaerobic conditions in selected organic solvent media containing 2% v/v 0.05 M phosphate buffer, 0.1 M KCl (pH 7.2) solution. polyvinyl acetate 104-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 17454383-2 2007 The voltammetric results have shown that the formal potential shifts anodically as the Au/MBT/PANI/AChE/PVAc thick-film biosensor responded to acetylthiocholine substrate addition under anaerobic conditions in selected organic solvent media containing 2% v/v 0.05 M phosphate buffer, 0.1 M KCl (pH 7.2) solution. Acetylthiocholine 143-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 17454383-2 2007 The voltammetric results have shown that the formal potential shifts anodically as the Au/MBT/PANI/AChE/PVAc thick-film biosensor responded to acetylthiocholine substrate addition under anaerobic conditions in selected organic solvent media containing 2% v/v 0.05 M phosphate buffer, 0.1 M KCl (pH 7.2) solution. Phosphates 266-275 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 17454383-2 2007 The voltammetric results have shown that the formal potential shifts anodically as the Au/MBT/PANI/AChE/PVAc thick-film biosensor responded to acetylthiocholine substrate addition under anaerobic conditions in selected organic solvent media containing 2% v/v 0.05 M phosphate buffer, 0.1 M KCl (pH 7.2) solution. Potassium Chloride 290-293 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 17096373-5 2007 Patient"s acetylcholinesterase (ACE) level was 3,319 IU/L in presentation and pralidoxim use was seen unnecessary for the treatment. pralidoxime 78-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-30 17080497-1 2007 Huperzine A is a potent, reversible acetylcholinesterase inhibitor. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 17008100-3 2007 Some new 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-one analogs were designed, synthesized, and evaluated for their inhibitory activity against both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-one 9-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-171 17008100-3 2007 Some new 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-one analogs were designed, synthesized, and evaluated for their inhibitory activity against both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-one 9-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-177 17243918-0 2007 L-cysteine supplementation prevents exercise-induced alterations in human erythrocyte membrane acetylcholinesterase and Na+,K+-ATPase activities. Cysteine 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 17243918-2 2007 The aim of this study was to investigate whether L-Cys supplementation prevents modulation of the activities of erythrocyte membrane acetylcholinesterase (AChE), Na(+),K(+)-ATPase and Mg(2+)-ATPase induced by free radicals in basketball players during training. Cysteine 49-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 17243918-2 2007 The aim of this study was to investigate whether L-Cys supplementation prevents modulation of the activities of erythrocyte membrane acetylcholinesterase (AChE), Na(+),K(+)-ATPase and Mg(2+)-ATPase induced by free radicals in basketball players during training. Cysteine 49-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 17243918-9 2007 When the players were supplemented with L-Cys, both AChE and Na(+),K(+)-ATPase activities remained unaltered post-exercise. Cysteine 40-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 17272964-1 2007 The objective of this study was to examine the effects of adjunctive treatment with the acetylcholinesterase inhibitor, donepezil, on cognitive deficits and psychopathology in schizophrenic patients treated with the antipsychotic, ziprasidone. Donepezil 120-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 17272964-1 2007 The objective of this study was to examine the effects of adjunctive treatment with the acetylcholinesterase inhibitor, donepezil, on cognitive deficits and psychopathology in schizophrenic patients treated with the antipsychotic, ziprasidone. ziprasidone 231-242 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 18044073-7 2007 Rivastigmine (Exelon, Novartis Basel-Switzerland) is a slowly reversible inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), while donepezil (Aricept, Pfizer, New York, USA) and galantamine (Reminyl, Janssen, New Jersey, USA) show no functional inhibition of BuChE, and are considered AChE-selective, rapidly-reversible inhibitors. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 18044073-7 2007 Rivastigmine (Exelon, Novartis Basel-Switzerland) is a slowly reversible inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), while donepezil (Aricept, Pfizer, New York, USA) and galantamine (Reminyl, Janssen, New Jersey, USA) show no functional inhibition of BuChE, and are considered AChE-selective, rapidly-reversible inhibitors. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 18044073-7 2007 Rivastigmine (Exelon, Novartis Basel-Switzerland) is a slowly reversible inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), while donepezil (Aricept, Pfizer, New York, USA) and galantamine (Reminyl, Janssen, New Jersey, USA) show no functional inhibition of BuChE, and are considered AChE-selective, rapidly-reversible inhibitors. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 309-313 18044073-7 2007 Rivastigmine (Exelon, Novartis Basel-Switzerland) is a slowly reversible inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), while donepezil (Aricept, Pfizer, New York, USA) and galantamine (Reminyl, Janssen, New Jersey, USA) show no functional inhibition of BuChE, and are considered AChE-selective, rapidly-reversible inhibitors. Rivastigmine 14-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 18044073-7 2007 Rivastigmine (Exelon, Novartis Basel-Switzerland) is a slowly reversible inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), while donepezil (Aricept, Pfizer, New York, USA) and galantamine (Reminyl, Janssen, New Jersey, USA) show no functional inhibition of BuChE, and are considered AChE-selective, rapidly-reversible inhibitors. Rivastigmine 14-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 18044073-7 2007 Rivastigmine (Exelon, Novartis Basel-Switzerland) is a slowly reversible inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), while donepezil (Aricept, Pfizer, New York, USA) and galantamine (Reminyl, Janssen, New Jersey, USA) show no functional inhibition of BuChE, and are considered AChE-selective, rapidly-reversible inhibitors. Rivastigmine 14-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 309-313 18044073-7 2007 Rivastigmine (Exelon, Novartis Basel-Switzerland) is a slowly reversible inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), while donepezil (Aricept, Pfizer, New York, USA) and galantamine (Reminyl, Janssen, New Jersey, USA) show no functional inhibition of BuChE, and are considered AChE-selective, rapidly-reversible inhibitors. Donepezil 155-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 309-313 17979787-4 2007 [(11)C]physostigmine, [(11)C]CP126,998 and 2-[(18)F]fluoro-CP118,954 were distributed corresponding well to the regional AChE activity in animals, and also former two probes were successfully applied to clinical PET trial. Physostigmine 7-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 17979787-4 2007 [(11)C]physostigmine, [(11)C]CP126,998 and 2-[(18)F]fluoro-CP118,954 were distributed corresponding well to the regional AChE activity in animals, and also former two probes were successfully applied to clinical PET trial. cp118 59-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 17979787-5 2007 The other approach is measuring cerebral AChE activity with radiolabeled acetylcholine analogue substrates. Acetylcholine 73-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 17979787-6 2007 We have developed the principle for measuring cerebral enzyme activity by PET and radiolabeled N-methylpiperidinyl esters for quantitative measurement of cerebral AChE activity. n-methylpiperidinyl esters 95-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 17979787-7 2007 N-[(11)C]methylipiperidin-4-yl acetate (MP4A) and N-[(11)C]methylpiperidin-4-yl propionate (MP4P) have been used for clinical studies of other demented disorders including Alzheimer"s disease (AD), and the probes have demonstrated not only the reduction of AChE activity in the cerebral cortex of patients with AD but also the inhibitory effects of donepezil and rivastigmine on AChE activity in the brain of AD patients. n-[(11)c]methylipiperidin-4-yl acetate 0-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 257-261 17979787-7 2007 N-[(11)C]methylipiperidin-4-yl acetate (MP4A) and N-[(11)C]methylpiperidin-4-yl propionate (MP4P) have been used for clinical studies of other demented disorders including Alzheimer"s disease (AD), and the probes have demonstrated not only the reduction of AChE activity in the cerebral cortex of patients with AD but also the inhibitory effects of donepezil and rivastigmine on AChE activity in the brain of AD patients. n-[(11)c]methylipiperidin-4-yl acetate 0-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 379-383 17979787-7 2007 N-[(11)C]methylipiperidin-4-yl acetate (MP4A) and N-[(11)C]methylpiperidin-4-yl propionate (MP4P) have been used for clinical studies of other demented disorders including Alzheimer"s disease (AD), and the probes have demonstrated not only the reduction of AChE activity in the cerebral cortex of patients with AD but also the inhibitory effects of donepezil and rivastigmine on AChE activity in the brain of AD patients. mp4a 40-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 257-261 17979787-7 2007 N-[(11)C]methylipiperidin-4-yl acetate (MP4A) and N-[(11)C]methylpiperidin-4-yl propionate (MP4P) have been used for clinical studies of other demented disorders including Alzheimer"s disease (AD), and the probes have demonstrated not only the reduction of AChE activity in the cerebral cortex of patients with AD but also the inhibitory effects of donepezil and rivastigmine on AChE activity in the brain of AD patients. mp4a 40-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 379-383 17979787-7 2007 N-[(11)C]methylipiperidin-4-yl acetate (MP4A) and N-[(11)C]methylpiperidin-4-yl propionate (MP4P) have been used for clinical studies of other demented disorders including Alzheimer"s disease (AD), and the probes have demonstrated not only the reduction of AChE activity in the cerebral cortex of patients with AD but also the inhibitory effects of donepezil and rivastigmine on AChE activity in the brain of AD patients. mp4p 92-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 257-261 17979787-7 2007 N-[(11)C]methylipiperidin-4-yl acetate (MP4A) and N-[(11)C]methylpiperidin-4-yl propionate (MP4P) have been used for clinical studies of other demented disorders including Alzheimer"s disease (AD), and the probes have demonstrated not only the reduction of AChE activity in the cerebral cortex of patients with AD but also the inhibitory effects of donepezil and rivastigmine on AChE activity in the brain of AD patients. mp4p 92-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 379-383 18045198-2 2007 Recent treatment of intoxications by organophosphorus compounds, such as nerve agents or pesticides, consists of rapid administration of anticholinergics and AChE reactivators. organophosphorus 37-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 18045198-6 2007 In this review, we would like to discuss relationship between structure of currently available AChE reactivators and their potency to reactivate cyclosarin-inhibited AChE. cyclohexyl methylphosphonofluoridate 145-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 18045198-6 2007 In this review, we would like to discuss relationship between structure of currently available AChE reactivators and their potency to reactivate cyclosarin-inhibited AChE. cyclohexyl methylphosphonofluoridate 145-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 18045198-7 2007 All outlined structural factors presented in this work should be helpful for the design of new generation of reactivators of cyclosarin-inhibited AChE. cyclohexyl methylphosphonofluoridate 125-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 17366821-1 2007 BACKGROUND: Organophosphate pesticides affect mammalian brain development through mechanisms separable from the inhibition of acetylcholinesterase (AChE) enzymatic activity and resultant cholinergic hyperstimulation. Organophosphates 12-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 17366821-1 2007 BACKGROUND: Organophosphate pesticides affect mammalian brain development through mechanisms separable from the inhibition of acetylcholinesterase (AChE) enzymatic activity and resultant cholinergic hyperstimulation. Organophosphates 12-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 17055616-4 2007 The results showed that all compounds act inside the AChE gorge, making pi-pi interactions and hydrogen bonds with Trp86 and Ser203 and by high HOMO energies of Ser2003 and high LUMO energies of N-aryl derivatives. Hydrogen 95-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 17000130-0 2007 Regulation of acetylcholinesterase expression by calcium signaling during calcium ionophore A23187- and thapsigargin-induced apoptosis. Calcium 49-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 17000130-0 2007 Regulation of acetylcholinesterase expression by calcium signaling during calcium ionophore A23187- and thapsigargin-induced apoptosis. Calcium 74-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 17000130-0 2007 Regulation of acetylcholinesterase expression by calcium signaling during calcium ionophore A23187- and thapsigargin-induced apoptosis. Calcimycin 92-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 17000130-0 2007 Regulation of acetylcholinesterase expression by calcium signaling during calcium ionophore A23187- and thapsigargin-induced apoptosis. Thapsigargin 104-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 17000130-3 2007 During apoptosis, treatment of HeLa and MDA-MB-435s cells with the calcium ionophore A23187 resulted in a significant increase in acetylcholinesterase mRNA and protein levels. Calcium 67-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 17000130-3 2007 During apoptosis, treatment of HeLa and MDA-MB-435s cells with the calcium ionophore A23187 resulted in a significant increase in acetylcholinesterase mRNA and protein levels. Calcimycin 85-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 17000130-4 2007 Chelation of intracellular Ca(2+) by BAPTA-AM (1,2-bis-(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid-acetoxymethyl ester), an intracellular Ca(2+) chelator, inhibited acetylcholinesterase expression. 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 37-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-191 17000130-4 2007 Chelation of intracellular Ca(2+) by BAPTA-AM (1,2-bis-(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid-acetoxymethyl ester), an intracellular Ca(2+) chelator, inhibited acetylcholinesterase expression. 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 47-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-191 17000130-5 2007 A23187 also enhanced the stability of acetylcholinesterase mRNA and increased the activity of acetylcholinesterase promoter, effects that were blocked by BAPTA-AM. Calcimycin 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 17000130-5 2007 A23187 also enhanced the stability of acetylcholinesterase mRNA and increased the activity of acetylcholinesterase promoter, effects that were blocked by BAPTA-AM. Calcimycin 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 17000130-5 2007 A23187 also enhanced the stability of acetylcholinesterase mRNA and increased the activity of acetylcholinesterase promoter, effects that were blocked by BAPTA-AM. 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 154-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 17000130-5 2007 A23187 also enhanced the stability of acetylcholinesterase mRNA and increased the activity of acetylcholinesterase promoter, effects that were blocked by BAPTA-AM. 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 154-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 17000130-6 2007 Perturbations of cellular Ca(2+) homeostasis by thapsigargin resulted in the increase of acetylcholinesterase expression as well as acetylcholinesterase promoter activity during thapsigargin induced apoptosis in HeLa and MDA-MB-435s cells, effects that were also inhibited by BAPTA-AM. Thapsigargin 48-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 17000130-6 2007 Perturbations of cellular Ca(2+) homeostasis by thapsigargin resulted in the increase of acetylcholinesterase expression as well as acetylcholinesterase promoter activity during thapsigargin induced apoptosis in HeLa and MDA-MB-435s cells, effects that were also inhibited by BAPTA-AM. Thapsigargin 48-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-152 17000130-6 2007 Perturbations of cellular Ca(2+) homeostasis by thapsigargin resulted in the increase of acetylcholinesterase expression as well as acetylcholinesterase promoter activity during thapsigargin induced apoptosis in HeLa and MDA-MB-435s cells, effects that were also inhibited by BAPTA-AM. Thapsigargin 178-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-152 17000130-7 2007 We further demonstrated that the transactivation of the human acetylcholinesterase promoter by A23187 and thapsigargin was partially mediated by a CCAAT motif within the -1270 to -1248 fragment of the human acetylcholinesterase promoter. Calcimycin 95-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 17000130-7 2007 We further demonstrated that the transactivation of the human acetylcholinesterase promoter by A23187 and thapsigargin was partially mediated by a CCAAT motif within the -1270 to -1248 fragment of the human acetylcholinesterase promoter. Calcimycin 95-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-227 17000130-7 2007 We further demonstrated that the transactivation of the human acetylcholinesterase promoter by A23187 and thapsigargin was partially mediated by a CCAAT motif within the -1270 to -1248 fragment of the human acetylcholinesterase promoter. Thapsigargin 106-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 17000130-7 2007 We further demonstrated that the transactivation of the human acetylcholinesterase promoter by A23187 and thapsigargin was partially mediated by a CCAAT motif within the -1270 to -1248 fragment of the human acetylcholinesterase promoter. Thapsigargin 106-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-227 17000130-9 2007 These results strongly suggest that cytosolic Ca(2+) plays a key role in acetylcholinesterase regulation during apoptosis induced by A23187 and thapsigargin. Calcimycin 133-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 17000130-9 2007 These results strongly suggest that cytosolic Ca(2+) plays a key role in acetylcholinesterase regulation during apoptosis induced by A23187 and thapsigargin. Thapsigargin 144-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 17994573-0 2007 Benzene-1,2-, 1,3-, and 1,4-di-N-substituted carbamates as conformationally constrained inhibitors of acetylcholinesterase. benzene-1,2-, 1,3-, and 1,4-di-n-substituted carbamates 0-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 17994573-1 2007 Benzene-1,2-, 1,3-, and 1,4-di-N-substituted carbamates (1-15) are synthesized as the conformationally constrained inhibitors of acetylcholinesterase and mimic gauche, eclipsed, and anti-conformations of acetylcholine, respectively. benzene-1,2-, 1,3-, and 1,4-di-n-substituted carbamates 0-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-149 17994573-2 2007 All carbamates 1-15 are characterized as the pseudo substrate inhibitors of acetylcholinesterase. carbamates 1-15 4-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 17994573-4 2007 Therefore, benzene-1,4-di-N-substituted carbamates (para compounds), with the angle of 180 degrees between two C(benzene)-O bonds, mimic the preferable anti C-O/C-N conformers of acetylcholine for the choline ethylene backbone in the acetylcholinesterase catalysis. benzene-1,4-di-n-substituted carbamates 11-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 234-254 17994573-4 2007 Therefore, benzene-1,4-di-N-substituted carbamates (para compounds), with the angle of 180 degrees between two C(benzene)-O bonds, mimic the preferable anti C-O/C-N conformers of acetylcholine for the choline ethylene backbone in the acetylcholinesterase catalysis. Benzene 11-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 234-254 17994573-4 2007 Therefore, benzene-1,4-di-N-substituted carbamates (para compounds), with the angle of 180 degrees between two C(benzene)-O bonds, mimic the preferable anti C-O/C-N conformers of acetylcholine for the choline ethylene backbone in the acetylcholinesterase catalysis. Acetylcholine 179-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 234-254 17994573-4 2007 Therefore, benzene-1,4-di-N-substituted carbamates (para compounds), with the angle of 180 degrees between two C(benzene)-O bonds, mimic the preferable anti C-O/C-N conformers of acetylcholine for the choline ethylene backbone in the acetylcholinesterase catalysis. Choline 185-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 234-254 17003227-4 2007 A selective acetylcholinesterase inhibitor, phenserine, in current human trials lowers both APP and Abeta. phenserine 44-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 17265683-5 2006 The search for an "omnipotent" oxime, effective in reactivation of AChE inhibited with both nerve agents and organophosphorus insecticides, is still ongoing. organophosphorus 109-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 17265684-4 2006 Acute toxicity of organophosphorus compounds is due to the inhibition of acetylcholinesterase, the critical enzyme in neurotransmission. organophosphorus 18-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 17265684-7 2006 Biotransformation reactions of organophosphorus compounds involve a large number of enzymatic reactions that can make them more or less toxic, or even non-toxic for acetylcholinesterase. organophosphorus 31-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-185 17030484-2 2006 We have found that these compounds inhibit AChE with a mild potency, mitigates the [Ca(2+)](c) triggered by high K(+), and cause neuroprotection against Ca(2+) overloading and free radical-induced neuronal death. Free Radicals 176-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 16797936-0 2006 Acetylcholinesterase inhibitor donepezil in the treatment of cognitive deficit in schizophrenia. Donepezil 31-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 17190371-2 2006 Galantamine is an acetylcholinesterase inhibitor that increases the effect of acetylcholine (ACh). Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 17190371-2 2006 Galantamine is an acetylcholinesterase inhibitor that increases the effect of acetylcholine (ACh). Acetylcholine 93-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 17252937-0 2006 Modeling of acetylcholinesterase inhibition by tacrine analogues using Bayesian-regularized Genetic Neural Networks and ensemble averaging. Tacrine 47-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 17252937-1 2006 Acetylcholinesterase inhibition was modeled for a set of 136 tacrine analogues using Bayesian-regularized Genetic Neural Networks (BRGNNs). Tacrine 61-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 17252938-1 2006 Antidotes currently used for organophosphorus pesticide and nerve agent intoxications consist of anticholinergics (atropine mainly) and acetylcholinesterase (AChE, EC 3.1.1.7) reactivators called oximes. organophosphorus 29-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 17252938-1 2006 Antidotes currently used for organophosphorus pesticide and nerve agent intoxications consist of anticholinergics (atropine mainly) and acetylcholinesterase (AChE, EC 3.1.1.7) reactivators called oximes. organophosphorus 29-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 17252938-1 2006 Antidotes currently used for organophosphorus pesticide and nerve agent intoxications consist of anticholinergics (atropine mainly) and acetylcholinesterase (AChE, EC 3.1.1.7) reactivators called oximes. Oximes 196-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 17252938-1 2006 Antidotes currently used for organophosphorus pesticide and nerve agent intoxications consist of anticholinergics (atropine mainly) and acetylcholinesterase (AChE, EC 3.1.1.7) reactivators called oximes. Oximes 196-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 17252938-9 2006 Two AChE reactivators, K027 and K033, achieved comparable reactivation potency as HI-6. asoxime chloride 82-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 17108904-4 2006 Computer modelling predicts that enzyme active sites are altered by H(2)O(2)-mediated oxidation in thioredoxin reductase (TR) and acetylcholinesterase (AchE), whereas cofactor nicotinamide adenine dinucleotide phosphate (reduced form) binding is affected in both catalase and TR but not in glutathione peroxidase. Hydrogen Peroxide 68-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 17108904-4 2006 Computer modelling predicts that enzyme active sites are altered by H(2)O(2)-mediated oxidation in thioredoxin reductase (TR) and acetylcholinesterase (AchE), whereas cofactor nicotinamide adenine dinucleotide phosphate (reduced form) binding is affected in both catalase and TR but not in glutathione peroxidase. Hydrogen Peroxide 68-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 18072133-6 2006 However, oxime HI-6 (33%) and obidoxime (23%) seem to be the best AChE reactivators for human relevant doses (10(-4) M and lower). Oximes 9-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 18072133-6 2006 However, oxime HI-6 (33%) and obidoxime (23%) seem to be the best AChE reactivators for human relevant doses (10(-4) M and lower). asoxime chloride 15-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 18072133-6 2006 However, oxime HI-6 (33%) and obidoxime (23%) seem to be the best AChE reactivators for human relevant doses (10(-4) M and lower). Obidoxime Chloride 30-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 17096183-0 2006 New safe method for preparation of sarin-exposed human erythrocytes acetylcholinesterase using non-toxic and stable sarin analogue isopropyl p-nitrophenyl methylphosphonate and its application to evaluation of nerve agent antidotes. Sarin 35-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 17096183-0 2006 New safe method for preparation of sarin-exposed human erythrocytes acetylcholinesterase using non-toxic and stable sarin analogue isopropyl p-nitrophenyl methylphosphonate and its application to evaluation of nerve agent antidotes. Sarin 116-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 17096183-0 2006 New safe method for preparation of sarin-exposed human erythrocytes acetylcholinesterase using non-toxic and stable sarin analogue isopropyl p-nitrophenyl methylphosphonate and its application to evaluation of nerve agent antidotes. 4-Nitrophenyl 2-propylmethylphosphonate 131-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 17096183-1 2006 INTRODUCTION: A non-toxic and stable sarin analogue, isopropyl p-nitrophenyl methylphosphonate (INMP), was synthesized for safe preparation of sarin-exposed acetylcholinesterase (AChE). 4-Nitrophenyl 2-propylmethylphosphonate 53-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-177 17096183-1 2006 INTRODUCTION: A non-toxic and stable sarin analogue, isopropyl p-nitrophenyl methylphosphonate (INMP), was synthesized for safe preparation of sarin-exposed acetylcholinesterase (AChE). 4-Nitrophenyl 2-propylmethylphosphonate 53-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 179-183 17096183-1 2006 INTRODUCTION: A non-toxic and stable sarin analogue, isopropyl p-nitrophenyl methylphosphonate (INMP), was synthesized for safe preparation of sarin-exposed acetylcholinesterase (AChE). inmp 96-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-177 17096183-1 2006 INTRODUCTION: A non-toxic and stable sarin analogue, isopropyl p-nitrophenyl methylphosphonate (INMP), was synthesized for safe preparation of sarin-exposed acetylcholinesterase (AChE). inmp 96-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 179-183 16942853-2 2006 We investigated in vitro interactions of TCP and its adamantane derivative--TAMORF with human erythrocyte acetylcholinesterase (AChE). Adamantane 53-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 16960032-3 2006 Organophosphate (OP) and carbamate pesticides, which are used in large amounts in agriculture to control insects, are designed to disrupt acetylcholine signaling by inhibiting the enzyme acetylcholinesterase (AChE). Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-207 16960032-3 2006 Organophosphate (OP) and carbamate pesticides, which are used in large amounts in agriculture to control insects, are designed to disrupt acetylcholine signaling by inhibiting the enzyme acetylcholinesterase (AChE). Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-213 16960032-3 2006 Organophosphate (OP) and carbamate pesticides, which are used in large amounts in agriculture to control insects, are designed to disrupt acetylcholine signaling by inhibiting the enzyme acetylcholinesterase (AChE). Carbamates 25-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-207 16960032-3 2006 Organophosphate (OP) and carbamate pesticides, which are used in large amounts in agriculture to control insects, are designed to disrupt acetylcholine signaling by inhibiting the enzyme acetylcholinesterase (AChE). Carbamates 25-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-213 16960032-3 2006 Organophosphate (OP) and carbamate pesticides, which are used in large amounts in agriculture to control insects, are designed to disrupt acetylcholine signaling by inhibiting the enzyme acetylcholinesterase (AChE). Acetylcholine 138-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-207 16960032-3 2006 Organophosphate (OP) and carbamate pesticides, which are used in large amounts in agriculture to control insects, are designed to disrupt acetylcholine signaling by inhibiting the enzyme acetylcholinesterase (AChE). Acetylcholine 138-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-213 17056129-3 2006 Huperzine A (HupA), a novel alkaloid isolated from a Chinese herb, has neuroprotective effects that go beyond the inhibition of AChE. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 17056129-3 2006 Huperzine A (HupA), a novel alkaloid isolated from a Chinese herb, has neuroprotective effects that go beyond the inhibition of AChE. huperzine A 13-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 17026971-6 2006 mAChR-mediated enhancements of AChE activity by carbachol were impaired following pre-exposure of SH-SY5Y cells with IL-1beta, already detectable at a concentration of 1 ng/ml and 1 h of exposure time. Carbachol 48-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 17723768-5 2006 AChE-based biosensors have demonstrated a higher sensitivity towards aldicarb (50% inhibition with 50 ppb) and carbaryl (50% inhibition with 85 ppb) while BChE biosensors have shown a higher affinity towards paraoxon (50% inhibition with 4 ppb) and chlorpyrifos-methyl oxon (50% inhibition with 1 ppb). Aldicarb 69-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 17723768-5 2006 AChE-based biosensors have demonstrated a higher sensitivity towards aldicarb (50% inhibition with 50 ppb) and carbaryl (50% inhibition with 85 ppb) while BChE biosensors have shown a higher affinity towards paraoxon (50% inhibition with 4 ppb) and chlorpyrifos-methyl oxon (50% inhibition with 1 ppb). Carbaryl 111-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 17723768-5 2006 AChE-based biosensors have demonstrated a higher sensitivity towards aldicarb (50% inhibition with 50 ppb) and carbaryl (50% inhibition with 85 ppb) while BChE biosensors have shown a higher affinity towards paraoxon (50% inhibition with 4 ppb) and chlorpyrifos-methyl oxon (50% inhibition with 1 ppb). Paraoxon 208-216 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 17723768-5 2006 AChE-based biosensors have demonstrated a higher sensitivity towards aldicarb (50% inhibition with 50 ppb) and carbaryl (50% inhibition with 85 ppb) while BChE biosensors have shown a higher affinity towards paraoxon (50% inhibition with 4 ppb) and chlorpyrifos-methyl oxon (50% inhibition with 1 ppb). fospirate 249-273 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 17154513-0 2006 Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole. 13-amidohuprines 11-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 17154513-1 2006 The acetylcholinesterase (AChE) inhibitory activity of a series of 13-amido derivatives of huprine Y, designed to enlarge the occupancy of the catalytic binding site by mimicking the piridone moiety present in (-)-huperzine A, has been assessed. 13-amido 67-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 17154513-1 2006 The acetylcholinesterase (AChE) inhibitory activity of a series of 13-amido derivatives of huprine Y, designed to enlarge the occupancy of the catalytic binding site by mimicking the piridone moiety present in (-)-huperzine A, has been assessed. 13-amido 67-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 17154513-1 2006 The acetylcholinesterase (AChE) inhibitory activity of a series of 13-amido derivatives of huprine Y, designed to enlarge the occupancy of the catalytic binding site by mimicking the piridone moiety present in (-)-huperzine A, has been assessed. huprine Y 91-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 17154513-1 2006 The acetylcholinesterase (AChE) inhibitory activity of a series of 13-amido derivatives of huprine Y, designed to enlarge the occupancy of the catalytic binding site by mimicking the piridone moiety present in (-)-huperzine A, has been assessed. huprine Y 91-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 16945529-2 2006 6-Oxygenated beta-carboline and beta-carbolinium derivatives based on the serotonin template were synthesized and tested in vitro for their ability to inhibit AChE and BChE, respectively. norharman 13-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 16945529-2 2006 6-Oxygenated beta-carboline and beta-carbolinium derivatives based on the serotonin template were synthesized and tested in vitro for their ability to inhibit AChE and BChE, respectively. beta-carbolinium 32-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 16945529-2 2006 6-Oxygenated beta-carboline and beta-carbolinium derivatives based on the serotonin template were synthesized and tested in vitro for their ability to inhibit AChE and BChE, respectively. Serotonin 74-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 16715131-1 2006 It has been shown that acetylcholinesterase (AChE) expression was induced during apoptosis and the anti-sense oligonucleotides and siRNA of AChE may prevent apoptosis in various cell types. Oligonucleotides 110-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 16715131-1 2006 It has been shown that acetylcholinesterase (AChE) expression was induced during apoptosis and the anti-sense oligonucleotides and siRNA of AChE may prevent apoptosis in various cell types. Oligonucleotides 110-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 16715131-7 2006 The induced AChE mRNA and protein expression could be blocked by SP600125, a specific inhibitor of SAPK/JNK, and small interfering RNA directed against JNK1/2. pyrazolanthrone 65-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-16 16982122-5 2006 In addition, since butyrylcholinesterase (BChE; EC 3.1.1.8) is considered an endogenous bioscavenger of anticholinesterase compounds and its interactions with oximes could be masked by AChE interactions, we evaluated kinetic parameters for interactions of tested oximes with native and tabun-inhibited human plasma BChE and compared them with results obtained previously for human erythrocyte acetylcholinesterase (AChE; EC 3.1.1.7). Oximes 159-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 185-189 16802134-2 2006 This unique termination mechanism makes acetylcholinesterase (AChE), the enzyme in charge of executing acetylcholine breakdown, a key component of cholinergic signaling. Acetylcholine 40-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 16868793-1 2006 OBJECTIVES: To evaluate long-term changes in acetylcholinesterase (AChE) activity in CSF and blood following donepezil treatment in relation to the concentration of donepezil and cognition in AD patients. Donepezil 109-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 16868793-1 2006 OBJECTIVES: To evaluate long-term changes in acetylcholinesterase (AChE) activity in CSF and blood following donepezil treatment in relation to the concentration of donepezil and cognition in AD patients. Donepezil 165-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 17124641-3 2006 RESULTS: The present study indicates that in the elderly persons, donepezil, an acetylcholinesterase inhibitor also exerts a marked effect on REM sleep parameters: REM density was increased whereas REM latency was reduced, thus, confirming the findings of our pilot study described earlier. Donepezil 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 16971069-1 2006 Pralidoxime iodide (2-PAM), an antidote approved for the reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning, dose-dependently hydrolyzed an acetylthiocholine iodide (ASCh). pralidoxime 0-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 16971069-1 2006 Pralidoxime iodide (2-PAM), an antidote approved for the reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning, dose-dependently hydrolyzed an acetylthiocholine iodide (ASCh). pralidoxime 0-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 16971069-1 2006 Pralidoxime iodide (2-PAM), an antidote approved for the reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning, dose-dependently hydrolyzed an acetylthiocholine iodide (ASCh). Organophosphates 114-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 16971069-1 2006 Pralidoxime iodide (2-PAM), an antidote approved for the reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning, dose-dependently hydrolyzed an acetylthiocholine iodide (ASCh). Organophosphates 114-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 16971069-1 2006 Pralidoxime iodide (2-PAM), an antidote approved for the reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning, dose-dependently hydrolyzed an acetylthiocholine iodide (ASCh). acetylthiocholine iodide 172-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 16971069-1 2006 Pralidoxime iodide (2-PAM), an antidote approved for the reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning, dose-dependently hydrolyzed an acetylthiocholine iodide (ASCh). acetylthiocholine iodide 172-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 16971069-1 2006 Pralidoxime iodide (2-PAM), an antidote approved for the reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning, dose-dependently hydrolyzed an acetylthiocholine iodide (ASCh). asch 198-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 16971069-1 2006 Pralidoxime iodide (2-PAM), an antidote approved for the reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning, dose-dependently hydrolyzed an acetylthiocholine iodide (ASCh). asch 198-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 16971069-6 2006 Next, we tried to compare this esterase-like activity of 2-PAM with that of obidoxime, which is known as a strong reactivator of inhibited AChE, and with diacetylmonoxime, known as a weak reactivator. Obidoxime Chloride 76-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 16971069-7 2006 All of these oximes showed esterase-like activity, and their strengths were consistent with those of known reactivators of inhibited AChE. Oximes 13-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 16971069-10 2006 We therefore strongly caution that the method of determining AChE activity with ASCh is not suitable for examining the effects of oximes. asch 80-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 17034128-0 2006 In-situ synthesis of a tacrine-triazole-based inhibitor of acetylcholinesterase: configurational selection imposed by steric interactions. Tacrine 23-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 17034128-0 2006 In-situ synthesis of a tacrine-triazole-based inhibitor of acetylcholinesterase: configurational selection imposed by steric interactions. Triazoles 31-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 17034128-2 2006 Thus, 1 (syn-TZ2PA6), a femtomolar AChE inhibitor, which is formed in a 1:1 mixture with its anti-isomer by solution phase reaction from 3 (TZ2) and 4 (PA6), can be synthesized exclusively inside the AChE gorge. syn-tz2pa6 9-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 17034128-2 2006 Thus, 1 (syn-TZ2PA6), a femtomolar AChE inhibitor, which is formed in a 1:1 mixture with its anti-isomer by solution phase reaction from 3 (TZ2) and 4 (PA6), can be synthesized exclusively inside the AChE gorge. syn-tz2pa6 9-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-204 17034128-4 2006 Ab initio QM/MM results show that the reaction in the AChE gorge occurs when 3/azide and 4/acetylene are extended in a parallel orientation. Azides 79-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 17034128-4 2006 Ab initio QM/MM results show that the reaction in the AChE gorge occurs when 3/azide and 4/acetylene are extended in a parallel orientation. Acetylene 91-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 17034128-9 2006 All of these results, thus, imply that inside the AChE gorge, the azide group of 3 and the acetylene group of 4 always remain parallel, with the consequence that 1 is the only product. Azides 66-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 17034128-9 2006 All of these results, thus, imply that inside the AChE gorge, the azide group of 3 and the acetylene group of 4 always remain parallel, with the consequence that 1 is the only product. Acetylene 91-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 17265683-5 2006 The search for an "omnipotent" oxime, effective in reactivation of AChE inhibited with both nerve agents and organophosphorus insecticides, is still ongoing. omnipotent" oxime 19-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 16934462-1 2006 Three asymmetrical AChE reactivators with cyano-moiety and propane linker were synthesized using modification of currently known synthetic pathways. Propane 59-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 16934462-2 2006 Their potency to reactivate AChE inhibited by nerve agent tabun and insecticide paraoxon was tested in vitro and compared to pralidoxime, HI-6, obidoxime, K027, and K048. Paraoxon 80-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 16934462-3 2006 According to the results, three compounds seem to be promising against paraoxon-inhibited AChE. Paraoxon 71-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 17047484-11 2006 These differences may reflect rivastigmine"s ability to inhibit BuChE and AChE. Rivastigmine 30-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 16962996-4 2006 Moreover, we show that BchE is subject to regulation by H(2)O(2) in a concentration-dependent manner as it was recently described for AchE. Hydrogen Peroxide 56-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 16982122-5 2006 In addition, since butyrylcholinesterase (BChE; EC 3.1.1.8) is considered an endogenous bioscavenger of anticholinesterase compounds and its interactions with oximes could be masked by AChE interactions, we evaluated kinetic parameters for interactions of tested oximes with native and tabun-inhibited human plasma BChE and compared them with results obtained previously for human erythrocyte acetylcholinesterase (AChE; EC 3.1.1.7). Oximes 159-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 415-419 16982122-8 2006 Therefore, BChE could scavenge tabun prior to AChE inhibition, but fast oxime-assisted reactivation of tabun-inhibited AChE or protection of AChE by oxime against inhibition with tabun would not be obstructed by interaction between BChE and oximes. Oximes 72-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 16982122-8 2006 Therefore, BChE could scavenge tabun prior to AChE inhibition, but fast oxime-assisted reactivation of tabun-inhibited AChE or protection of AChE by oxime against inhibition with tabun would not be obstructed by interaction between BChE and oximes. Oximes 72-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 17286103-0 2006 The effect of ionic strength on the reversible inhibition of acetylcholinesterase under the influence of thionephosphonates of different hydrophobicity. thionephosphonates 105-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 17105484-0 2006 Ensembles of Bayesian-regularized genetic neural networks for modeling of acetylcholinesterase inhibition by huprines. huprines 109-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 17194020-0 2006 New group of xylene linker-containing acetylcholinesterase reactivators as antidotes against the nerve agent cyclosarin. Xylenes 13-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 17194020-0 2006 New group of xylene linker-containing acetylcholinesterase reactivators as antidotes against the nerve agent cyclosarin. cyclohexyl methylphosphonofluoridate 109-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 17194020-1 2006 Nerve agents such as sarin, cyclosarin and tabun are organophosphorus substances able to inhibit the enzyme acetylcholinesterase (AChE; EC 3.1.1.7). cyclohexyl methylphosphonofluoridate 28-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 17194020-1 2006 Nerve agents such as sarin, cyclosarin and tabun are organophosphorus substances able to inhibit the enzyme acetylcholinesterase (AChE; EC 3.1.1.7). cyclohexyl methylphosphonofluoridate 28-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 17194020-1 2006 Nerve agents such as sarin, cyclosarin and tabun are organophosphorus substances able to inhibit the enzyme acetylcholinesterase (AChE; EC 3.1.1.7). tabun 43-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 17194020-1 2006 Nerve agents such as sarin, cyclosarin and tabun are organophosphorus substances able to inhibit the enzyme acetylcholinesterase (AChE; EC 3.1.1.7). tabun 43-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 17194020-1 2006 Nerve agents such as sarin, cyclosarin and tabun are organophosphorus substances able to inhibit the enzyme acetylcholinesterase (AChE; EC 3.1.1.7). organophosphorus 53-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 17194020-1 2006 Nerve agents such as sarin, cyclosarin and tabun are organophosphorus substances able to inhibit the enzyme acetylcholinesterase (AChE; EC 3.1.1.7). organophosphorus 53-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 17194020-4 2006 In this work, reactivation potency of nine newly developed AChE reactivators with an incorporated xylene ring in their structure was measured in vitro. Xylenes 98-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 16413803-3 2006 It is achieved by acetylcholinesterase (AChE) inhibition, the enzyme responsible for acetylcholine hydrolysis. Acetylcholine 18-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 16413803-6 2006 In this work we proposed molecular hybrids of tacrine with donepezil (fusion of these structures), in order to suggest new proposals of AChE inhibitors for future treatment of AD. Tacrine 46-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 16413803-6 2006 In this work we proposed molecular hybrids of tacrine with donepezil (fusion of these structures), in order to suggest new proposals of AChE inhibitors for future treatment of AD. Donepezil 59-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 16909309-6 2006 In addition, activities of neuropathy target esterase and acetylcholinesterase were significantly reduced after exposure to 5 mM TOCP for 12 hr. Tri-o-tolyl phosphate 129-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 16901641-4 2006 A single oral dose (3mg) of donepezil, an acetylcholinesterase inhibitor that is commonly used to treat Alzheimer"s disease (AD), improved SAI in DAI patients with wide individual variations that ranged from an increase of 77-18% of test size. Donepezil 28-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 17723708-0 2006 Organophosphorus insecticides extraction and heterogeneous oxidation on column for analysis with an acetylcholinesterase (AChE) biosensor. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 17723708-0 2006 Organophosphorus insecticides extraction and heterogeneous oxidation on column for analysis with an acetylcholinesterase (AChE) biosensor. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 17723708-1 2006 This paper presents an analysis method for organophosphorus insecticides based on AChE biosensors coupled with a preconcentration and oxidation on a solid phase column. organophosphorus 43-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 17723708-7 2006 The LODs of the AChE biosensor without sample preconcentration were 8 x 10(-8) M for paraoxon and 1 x 10(-7) M dichlorvos and the LOD obtained after the preconcentration step were 2.5 x 10(-8) M for paraoxon and 2.5 x 10(-8) M for dichlorvos. Paraoxon 85-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 17723708-7 2006 The LODs of the AChE biosensor without sample preconcentration were 8 x 10(-8) M for paraoxon and 1 x 10(-7) M dichlorvos and the LOD obtained after the preconcentration step were 2.5 x 10(-8) M for paraoxon and 2.5 x 10(-8) M for dichlorvos. Paraoxon 199-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 17723708-7 2006 The LODs of the AChE biosensor without sample preconcentration were 8 x 10(-8) M for paraoxon and 1 x 10(-7) M dichlorvos and the LOD obtained after the preconcentration step were 2.5 x 10(-8) M for paraoxon and 2.5 x 10(-8) M for dichlorvos. Dichlorvos 111-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 16828550-1 2006 New bis-pyridinium oxime reactivators connected with CH2O(CH2)n OCH2 linkers between two pyridinium rings were designed and synthesized, and their reactivation potency was evaluated for AChE inhibited by organophosphorus VX agent. bis-pyridinium oxime 4-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 16828550-1 2006 New bis-pyridinium oxime reactivators connected with CH2O(CH2)n OCH2 linkers between two pyridinium rings were designed and synthesized, and their reactivation potency was evaluated for AChE inhibited by organophosphorus VX agent. pyridine 8-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 16828550-1 2006 New bis-pyridinium oxime reactivators connected with CH2O(CH2)n OCH2 linkers between two pyridinium rings were designed and synthesized, and their reactivation potency was evaluated for AChE inhibited by organophosphorus VX agent. organophosphorus 204-220 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 16828550-2 2006 Among the prepared compounds, 1,2-dimethoxy-ethylene-bis-N,N"-4-pyridiumaldoxime dichloride 5a was the most potent and appeared to be the most promising compound as a potential reactivator for AChE inhibited by organophosphorus VX agent. 1,2-dimethoxy-ethylene-bis-N,N'-4-pyridiumaldoxime dichloride 30-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-197 16828550-2 2006 Among the prepared compounds, 1,2-dimethoxy-ethylene-bis-N,N"-4-pyridiumaldoxime dichloride 5a was the most potent and appeared to be the most promising compound as a potential reactivator for AChE inhibited by organophosphorus VX agent. organophosphorus 211-227 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-197 16989609-3 2006 AChE activity was determined by the colorimetric Ellman"s method and [Ca2(+)](int) using the fluorescent fura-2 acetoxymethyl ester. fura-2-am 105-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 16397771-2 2006 Twenty-two positive transformants were obtained by Mut(+)/Mut(s) phenotypes screening in MD/MM medium and polymerase chain reaction amplification, and four recombinant P. pastoris strains that could secrete active AChE at high level were identified by simple and specific development reaction with indoxyl acetate as the chromogenic substrate. indoxyl acetate 298-313 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-218 16397771-3 2006 In shake-flask culture induced with methanol, the recombinant human AChE (rhAChE) content was about 76% of the total secreted proteins, and rhAChE activity in supernatant was 40 U/ml. Methanol 36-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 16909200-2 2006 The study of 55 paired specimens of healthy (HG) and cancerous gut (CG) showed that acetylcholinesterase (AChE) activity fell by 32% and butyrylcholinesterase (BuChE) activity by 58% in CG. cg 68-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 16909200-2 2006 The study of 55 paired specimens of healthy (HG) and cancerous gut (CG) showed that acetylcholinesterase (AChE) activity fell by 32% and butyrylcholinesterase (BuChE) activity by 58% in CG. cg 68-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 16909200-4 2006 The high level of the AChE-H mRNA explains the abundance of AChE-H subunits in HG, which as glycosylphosphatidylinositol (GPI)-anchored amphiphilic AChE dimers (G2(A)) and monomers (G1(A)) account for 69% of AChE activity. Glycosylphosphatidylinositols 92-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 16909200-4 2006 The high level of the AChE-H mRNA explains the abundance of AChE-H subunits in HG, which as glycosylphosphatidylinositol (GPI)-anchored amphiphilic AChE dimers (G2(A)) and monomers (G1(A)) account for 69% of AChE activity. Glycosylphosphatidylinositols 92-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 16909200-4 2006 The high level of the AChE-H mRNA explains the abundance of AChE-H subunits in HG, which as glycosylphosphatidylinositol (GPI)-anchored amphiphilic AChE dimers (G2(A)) and monomers (G1(A)) account for 69% of AChE activity. Glycosylphosphatidylinositols 92-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 16909200-4 2006 The high level of the AChE-H mRNA explains the abundance of AChE-H subunits in HG, which as glycosylphosphatidylinositol (GPI)-anchored amphiphilic AChE dimers (G2(A)) and monomers (G1(A)) account for 69% of AChE activity. Glycosylphosphatidylinositols 92-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 16909200-4 2006 The high level of the AChE-H mRNA explains the abundance of AChE-H subunits in HG, which as glycosylphosphatidylinositol (GPI)-anchored amphiphilic AChE dimers (G2(A)) and monomers (G1(A)) account for 69% of AChE activity. Glycosylphosphatidylinositols 122-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 16909200-4 2006 The high level of the AChE-H mRNA explains the abundance of AChE-H subunits in HG, which as glycosylphosphatidylinositol (GPI)-anchored amphiphilic AChE dimers (G2(A)) and monomers (G1(A)) account for 69% of AChE activity. Glycosylphosphatidylinositols 122-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 16909200-4 2006 The high level of the AChE-H mRNA explains the abundance of AChE-H subunits in HG, which as glycosylphosphatidylinositol (GPI)-anchored amphiphilic AChE dimers (G2(A)) and monomers (G1(A)) account for 69% of AChE activity. Glycosylphosphatidylinositols 122-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 16909200-4 2006 The high level of the AChE-H mRNA explains the abundance of AChE-H subunits in HG, which as glycosylphosphatidylinositol (GPI)-anchored amphiphilic AChE dimers (G2(A)) and monomers (G1(A)) account for 69% of AChE activity. Glycosylphosphatidylinositols 122-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 16769211-3 2006 Here, we applied the localized surface plasmon resonance (LSPR) of gold nanoparticles covalently coupled with acetylcholinesterase (AChE) to create a biosensor for detecting an example of serial signals responding to paraoxon in the range of 1-100 ppb by an AChE modified LSPR sensor immersing in a 0.05 mM ACh solution. Paraoxon 217-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 16769211-3 2006 Here, we applied the localized surface plasmon resonance (LSPR) of gold nanoparticles covalently coupled with acetylcholinesterase (AChE) to create a biosensor for detecting an example of serial signals responding to paraoxon in the range of 1-100 ppb by an AChE modified LSPR sensor immersing in a 0.05 mM ACh solution. Paraoxon 217-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 16769211-3 2006 Here, we applied the localized surface plasmon resonance (LSPR) of gold nanoparticles covalently coupled with acetylcholinesterase (AChE) to create a biosensor for detecting an example of serial signals responding to paraoxon in the range of 1-100 ppb by an AChE modified LSPR sensor immersing in a 0.05 mM ACh solution. Paraoxon 217-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 258-262 16769211-3 2006 Here, we applied the localized surface plasmon resonance (LSPR) of gold nanoparticles covalently coupled with acetylcholinesterase (AChE) to create a biosensor for detecting an example of serial signals responding to paraoxon in the range of 1-100 ppb by an AChE modified LSPR sensor immersing in a 0.05 mM ACh solution. Acetylcholine 132-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 16769211-3 2006 Here, we applied the localized surface plasmon resonance (LSPR) of gold nanoparticles covalently coupled with acetylcholinesterase (AChE) to create a biosensor for detecting an example of serial signals responding to paraoxon in the range of 1-100 ppb by an AChE modified LSPR sensor immersing in a 0.05 mM ACh solution. Acetylcholine 132-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 258-262 16769211-4 2006 The underlying mechanism is that paraoxon prevents acetylcholine chloride (ACh) reacting with AChE by destroying the OH bond of serine in AChE. Paraoxon 33-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 16769211-4 2006 The underlying mechanism is that paraoxon prevents acetylcholine chloride (ACh) reacting with AChE by destroying the OH bond of serine in AChE. Paraoxon 33-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 16769211-4 2006 The underlying mechanism is that paraoxon prevents acetylcholine chloride (ACh) reacting with AChE by destroying the OH bond of serine in AChE. Acetylcholine 51-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 16769211-4 2006 The underlying mechanism is that paraoxon prevents acetylcholine chloride (ACh) reacting with AChE by destroying the OH bond of serine in AChE. Acetylcholine 51-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 16769211-4 2006 The underlying mechanism is that paraoxon prevents acetylcholine chloride (ACh) reacting with AChE by destroying the OH bond of serine in AChE. Acetylcholine 75-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 16769211-4 2006 The underlying mechanism is that paraoxon prevents acetylcholine chloride (ACh) reacting with AChE by destroying the OH bond of serine in AChE. Acetylcholine 75-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 16769211-4 2006 The underlying mechanism is that paraoxon prevents acetylcholine chloride (ACh) reacting with AChE by destroying the OH bond of serine in AChE. Serine 128-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 16769211-4 2006 The underlying mechanism is that paraoxon prevents acetylcholine chloride (ACh) reacting with AChE by destroying the OH bond of serine in AChE. Serine 128-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 16769211-5 2006 We found that the AChE modified LSPR sensors prepared by incubation with 12.5 mU/mL of AChE in phosphate buffer solution at pH 8.5 room temperature for 14 h have the best linear inhibition response with a 0.234 ppb limit of paraoxon detection. Phosphates 95-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 16769211-5 2006 We found that the AChE modified LSPR sensors prepared by incubation with 12.5 mU/mL of AChE in phosphate buffer solution at pH 8.5 room temperature for 14 h have the best linear inhibition response with a 0.234 ppb limit of paraoxon detection. Phosphates 95-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 16769211-5 2006 We found that the AChE modified LSPR sensors prepared by incubation with 12.5 mU/mL of AChE in phosphate buffer solution at pH 8.5 room temperature for 14 h have the best linear inhibition response with a 0.234 ppb limit of paraoxon detection. Paraoxon 224-232 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 16769211-5 2006 We found that the AChE modified LSPR sensors prepared by incubation with 12.5 mU/mL of AChE in phosphate buffer solution at pH 8.5 room temperature for 14 h have the best linear inhibition response with a 0.234 ppb limit of paraoxon detection. Paraoxon 224-232 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 16769211-7 2006 The sensor remained 94% of its original activity after six cycles of inhibition with 500 ppb paraoxon followed with reactivation of AChE by 0.5 mM 2-pyriding-aldoxime methoiodide (2-PAM). 2-pyriding-aldoxime methoiodide 147-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 16769211-7 2006 The sensor remained 94% of its original activity after six cycles of inhibition with 500 ppb paraoxon followed with reactivation of AChE by 0.5 mM 2-pyriding-aldoxime methoiodide (2-PAM). Pralidoxime Compounds 180-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 16769211-9 2006 In conclusion, we demonstrated that the AChE modified LSPR sensors can be used to determine the concentration of paraoxon biosensor with high sensitive and stable characteristics. Paraoxon 113-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 17415417-0 2006 Interaction of acetylcholinesterase inhibitor donepezil with ionic channels of the neuronal membrane. Donepezil 46-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 16862548-3 2006 In this study, we investigated the effects of an acetylcholinesterase inhibitor, huperzine A (Hup A), on APP processing and Abeta generation in human embryonic kidney 293 cells transfected with human APP bearing the Swedish mutation (HEK293 APPsw). huperzine A 81-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 16771827-2 2006 In the current study, we investigated the effects of bis(7)-tacrine, a novel dimeric AChE inhibitor, on Abeta-induced neurotoxicity in primary cortical neurons. 1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydroacridine 53-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 16946590-10 2006 It is believed that the plasma concentration of Ach is elevated by ranitidine and nizatidine, which possesses an anti-AchE activity, and that the increased the plasma concentration of Ach facilitated release of motilin, elevating the plasma concentration of motilin. Acetylcholine 48-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 16801396-0 2006 Comparison of polyethylene glycol-conjugated recombinant human acetylcholinesterase and serum human butyrylcholinesterase as bioscavengers of organophosphate compounds. Polyethylene Glycols 14-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 16801396-0 2006 Comparison of polyethylene glycol-conjugated recombinant human acetylcholinesterase and serum human butyrylcholinesterase as bioscavengers of organophosphate compounds. Organophosphates 142-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 16801396-1 2006 Comparative protection studies in mice demonstrate that on a molar basis, recombinant human acetylcholinesterase (rHuAChE) confers higher levels of protection than native human butyrylcholinesterase (HuBChE) against organophosphate (OP) compound intoxication. Organophosphates 216-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 16762377-0 2006 Acetylcholinesterase inhibitors used in treatment of Alzheimer"s disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade. Acetylcholine 119-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 16762377-1 2006 We show here that donepezil, galanathamine and tacrine, therapeutic acetylcholinesterase inhibitors currently being used for treatment of Alzheimer"s disease, protect neuronal cells in a time- and concentration-dependent manner from glutamate neurotoxicity that involves apoptosis. Donepezil 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 16762377-1 2006 We show here that donepezil, galanathamine and tacrine, therapeutic acetylcholinesterase inhibitors currently being used for treatment of Alzheimer"s disease, protect neuronal cells in a time- and concentration-dependent manner from glutamate neurotoxicity that involves apoptosis. galanathamine 29-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 16762377-1 2006 We show here that donepezil, galanathamine and tacrine, therapeutic acetylcholinesterase inhibitors currently being used for treatment of Alzheimer"s disease, protect neuronal cells in a time- and concentration-dependent manner from glutamate neurotoxicity that involves apoptosis. Tacrine 47-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 16762377-1 2006 We show here that donepezil, galanathamine and tacrine, therapeutic acetylcholinesterase inhibitors currently being used for treatment of Alzheimer"s disease, protect neuronal cells in a time- and concentration-dependent manner from glutamate neurotoxicity that involves apoptosis. Glutamic Acid 233-242 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 16946590-10 2006 It is believed that the plasma concentration of Ach is elevated by ranitidine and nizatidine, which possesses an anti-AchE activity, and that the increased the plasma concentration of Ach facilitated release of motilin, elevating the plasma concentration of motilin. Ranitidine 67-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 16946590-10 2006 It is believed that the plasma concentration of Ach is elevated by ranitidine and nizatidine, which possesses an anti-AchE activity, and that the increased the plasma concentration of Ach facilitated release of motilin, elevating the plasma concentration of motilin. Nizatidine 82-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 16751247-2 2006 Changes in DEFET from variously charged Tb3+ -chelates revealed net potentials of -20 mV at the nAChR agonist sites and -14 mV at the entrance to the AChE active site, in physiological ionic strength conditions. tb3+ 40-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 16807370-1 2006 Organophosphate pesticides (OPs), known inhibitors of acetylcholinesterase (AChE), are used extensively throughout the world. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 16735118-0 2006 Synthesis and efficacy of 1-[bis(4-fluorophenyl)-methyl]piperazine derivatives for acetylcholinesterase inhibition, as a stimulant of central cholinergic neurotransmission in Alzheimer"s disease. 1-(bis(4-fluorophenyl)methyl)piperazine 26-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 16807370-1 2006 Organophosphate pesticides (OPs), known inhibitors of acetylcholinesterase (AChE), are used extensively throughout the world. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 16807370-1 2006 Organophosphate pesticides (OPs), known inhibitors of acetylcholinesterase (AChE), are used extensively throughout the world. OPS 28-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 16807370-1 2006 Organophosphate pesticides (OPs), known inhibitors of acetylcholinesterase (AChE), are used extensively throughout the world. OPS 28-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 16766477-5 2006 The anti-AChE activity of paraoxon (maximum 3 muM) and anti-NTE activity of mipafox (250 muM) in SY5Y cells were prevented by biodegradation with OPH. Paraoxon 26-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 17194020-8 2006 Moreover, from the obtained results it could be deduced that AChE reactivators with a functional oxime group in position-2 are the most potent AChE reactivators in the case of cyclosarin intoxications. Oximes 97-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 17194020-8 2006 Moreover, from the obtained results it could be deduced that AChE reactivators with a functional oxime group in position-2 are the most potent AChE reactivators in the case of cyclosarin intoxications. Oximes 97-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 17194020-8 2006 Moreover, from the obtained results it could be deduced that AChE reactivators with a functional oxime group in position-2 are the most potent AChE reactivators in the case of cyclosarin intoxications. cyclohexyl methylphosphonofluoridate 176-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 17194020-8 2006 Moreover, from the obtained results it could be deduced that AChE reactivators with a functional oxime group in position-2 are the most potent AChE reactivators in the case of cyclosarin intoxications. cyclohexyl methylphosphonofluoridate 176-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 17194021-6 2006 Furthermore effects of two conventional oximes paralidoxime (A) and obidoxime (B) on reactivation of the inhibited hAChE were studied but low reactivity was shown by both the oximes. Oximes 40-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-120 17194021-6 2006 Furthermore effects of two conventional oximes paralidoxime (A) and obidoxime (B) on reactivation of the inhibited hAChE were studied but low reactivity was shown by both the oximes. paralidoxime 47-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-120 17194021-6 2006 Furthermore effects of two conventional oximes paralidoxime (A) and obidoxime (B) on reactivation of the inhibited hAChE were studied but low reactivity was shown by both the oximes. Obidoxime Chloride 68-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-120 16780806-0 2006 Kinetic analysis of the protection afforded by reversible inhibitors against irreversible inhibition of acetylcholinesterase by highly toxic organophosphorus compounds. Organophosphorus Compounds 141-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 16600641-1 2006 Acetylcholinesterase inhibitors (AChEI) such as donepezil act in mild Alzheimer"s disease (AD) by increasing cholinergic tone. Donepezil 48-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 16766477-6 2006 Anti-AChE activities of mipafox, methyl parathion, and demeton-S were partially ameliorated, depending on OP concentration. mipafox 24-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 16766477-6 2006 Anti-AChE activities of mipafox, methyl parathion, and demeton-S were partially ameliorated, depending on OP concentration. Methyl Parathion 33-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 16766477-6 2006 Anti-AChE activities of mipafox, methyl parathion, and demeton-S were partially ameliorated, depending on OP concentration. Disulfoton 55-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 16791318-0 2006 Design and activity of cationic fullerene derivatives as inhibitors of acetylcholinesterase. Fullerenes 32-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 16791318-1 2006 Four different regioisomers of cationic bis-N,N-dimethylfulleropyrrolidinium salts have been prepared and evaluated as inhibitors of the enzymatic activity of acetylcholinesterase. bis-n,n-dimethylfulleropyrrolidinium salts 40-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 16821887-3 2006 The ACHE...sarin and ACHE...acetylcholine (Ach) structures have been optimized using DFT based two-layer ONIOM hybrid calculations. Acetylcholine 28-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 16821887-3 2006 The ACHE...sarin and ACHE...acetylcholine (Ach) structures have been optimized using DFT based two-layer ONIOM hybrid calculations. Acetylcholine 43-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 16821887-3 2006 The ACHE...sarin and ACHE...acetylcholine (Ach) structures have been optimized using DFT based two-layer ONIOM hybrid calculations. Acetylcholine 43-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 16821887-6 2006 An inhibition mechanism during the uptake of sarin inside the ACHE cavity has been proposed from the comparison of the energetics of the ACHE...sarin and ACHE...Ach complexes. Acetylcholine 161-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 16720069-2 2006 OP inhibit acetylcholinesterase (AChE), therefore, standard treatment includes AChE reactivators (oximes) in combination with antimuscarinic agents. Oximes 98-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 16740352-2 2006 Presently, standard treatment of poisoning by OP includes administration of atropine as an antimuscarinic agent and of oximes, e.g. obidoxime or pralidoxime, as reactivators of OP-inhibited acetylcholinesterase (AChE), but is considered to be rather ineffective with certain nerve agents. Oximes 119-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 212-216 16740352-4 2006 A computer simulation based on combination of AChE kinetic data (inhibition, reactivation, aging) with OP toxicokinetics and oxime pharmacokinetics allows the calculation of AChE activities at different scenarios and may facilitate to define effective oxime concentrations and to optimize oxime dosage in OP poisoning. Oximes 125-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 16740352-4 2006 A computer simulation based on combination of AChE kinetic data (inhibition, reactivation, aging) with OP toxicokinetics and oxime pharmacokinetics allows the calculation of AChE activities at different scenarios and may facilitate to define effective oxime concentrations and to optimize oxime dosage in OP poisoning. Oximes 252-257 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 16740352-4 2006 A computer simulation based on combination of AChE kinetic data (inhibition, reactivation, aging) with OP toxicokinetics and oxime pharmacokinetics allows the calculation of AChE activities at different scenarios and may facilitate to define effective oxime concentrations and to optimize oxime dosage in OP poisoning. Oximes 252-257 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 16740352-4 2006 A computer simulation based on combination of AChE kinetic data (inhibition, reactivation, aging) with OP toxicokinetics and oxime pharmacokinetics allows the calculation of AChE activities at different scenarios and may facilitate to define effective oxime concentrations and to optimize oxime dosage in OP poisoning. Oximes 252-257 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 16740352-4 2006 A computer simulation based on combination of AChE kinetic data (inhibition, reactivation, aging) with OP toxicokinetics and oxime pharmacokinetics allows the calculation of AChE activities at different scenarios and may facilitate to define effective oxime concentrations and to optimize oxime dosage in OP poisoning. Oximes 252-257 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 16740352-5 2006 On the base of species-specific kinetic data this model was used to calculate AChE activities in humans and pigs after percutaneous exposure to 5 x LD50 VX and treatment with HI 6. asoxime chloride 175-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 16788077-0 2006 Acetylcholinesterase inhibitors for Alzheimer"s disease: anti-inflammatories in acetylcholine clothing! Acetylcholine 80-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 16881015-4 2006 The effects of the five alkaloids on human red blood cell (RBC) acetylcholinesterase (AChE) and human plasma butyrylcholinesterase (BChE) were further studied, and their IC (50) values for human RBC AChE were 6.4 +/- 0.003 microM, 16.9 +/- 0.018 microM, 5.7 +/- 0.004 microM, 6.5 +/- 0.013 microM and 7.7 +/- 0.001 microM, respectively, and the IC50 values for human plasma BChE were 12.5 +/- 0.026 microM, 2.1 +/- 0.005 microM, 5.2 +/- 0.002 microM, 7.3 +/- 0.005 microM and 0.7 +/- 0.001 microM, respectively. Alkaloids 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 16881015-5 2006 These data suggest, therefore, that N-demethylpuqietinone, hupeheninoside, ebeiedinone, yibeinoside A and chuanbeinone have both anti-RBC AChE and anti-plasma BChE activities, N-demethylpuqietinone is a selective inhibitor of AChE, whereas hupeheninoside and chuanbeinone are the selective inhibitors of BChE. N-demethylpuqietinone 36-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 16881015-5 2006 These data suggest, therefore, that N-demethylpuqietinone, hupeheninoside, ebeiedinone, yibeinoside A and chuanbeinone have both anti-RBC AChE and anti-plasma BChE activities, N-demethylpuqietinone is a selective inhibitor of AChE, whereas hupeheninoside and chuanbeinone are the selective inhibitors of BChE. N-demethylpuqietinone 36-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-230 16881015-5 2006 These data suggest, therefore, that N-demethylpuqietinone, hupeheninoside, ebeiedinone, yibeinoside A and chuanbeinone have both anti-RBC AChE and anti-plasma BChE activities, N-demethylpuqietinone is a selective inhibitor of AChE, whereas hupeheninoside and chuanbeinone are the selective inhibitors of BChE. hupeheninoside 59-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 16881015-5 2006 These data suggest, therefore, that N-demethylpuqietinone, hupeheninoside, ebeiedinone, yibeinoside A and chuanbeinone have both anti-RBC AChE and anti-plasma BChE activities, N-demethylpuqietinone is a selective inhibitor of AChE, whereas hupeheninoside and chuanbeinone are the selective inhibitors of BChE. hupeheninoside 59-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-230 16881015-5 2006 These data suggest, therefore, that N-demethylpuqietinone, hupeheninoside, ebeiedinone, yibeinoside A and chuanbeinone have both anti-RBC AChE and anti-plasma BChE activities, N-demethylpuqietinone is a selective inhibitor of AChE, whereas hupeheninoside and chuanbeinone are the selective inhibitors of BChE. Ebeiedinone 75-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 16881015-5 2006 These data suggest, therefore, that N-demethylpuqietinone, hupeheninoside, ebeiedinone, yibeinoside A and chuanbeinone have both anti-RBC AChE and anti-plasma BChE activities, N-demethylpuqietinone is a selective inhibitor of AChE, whereas hupeheninoside and chuanbeinone are the selective inhibitors of BChE. Ebeiedinone 75-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-230 16881015-5 2006 These data suggest, therefore, that N-demethylpuqietinone, hupeheninoside, ebeiedinone, yibeinoside A and chuanbeinone have both anti-RBC AChE and anti-plasma BChE activities, N-demethylpuqietinone is a selective inhibitor of AChE, whereas hupeheninoside and chuanbeinone are the selective inhibitors of BChE. yibeinoside A 88-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 16881015-5 2006 These data suggest, therefore, that N-demethylpuqietinone, hupeheninoside, ebeiedinone, yibeinoside A and chuanbeinone have both anti-RBC AChE and anti-plasma BChE activities, N-demethylpuqietinone is a selective inhibitor of AChE, whereas hupeheninoside and chuanbeinone are the selective inhibitors of BChE. yibeinoside A 88-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-230 16881015-5 2006 These data suggest, therefore, that N-demethylpuqietinone, hupeheninoside, ebeiedinone, yibeinoside A and chuanbeinone have both anti-RBC AChE and anti-plasma BChE activities, N-demethylpuqietinone is a selective inhibitor of AChE, whereas hupeheninoside and chuanbeinone are the selective inhibitors of BChE. chuanbeinone 106-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 16881015-5 2006 These data suggest, therefore, that N-demethylpuqietinone, hupeheninoside, ebeiedinone, yibeinoside A and chuanbeinone have both anti-RBC AChE and anti-plasma BChE activities, N-demethylpuqietinone is a selective inhibitor of AChE, whereas hupeheninoside and chuanbeinone are the selective inhibitors of BChE. chuanbeinone 106-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-230 16797163-3 2006 Acetylcholinesterase inhibitors, such as Physostigmine and Rivastigmine, are considered effective treatments for cognitive decline in Alzheimer"s Disease, where the loss of cholinergic neurons is thought to be responsible for various cognitive deficits. Physostigmine 41-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 16797163-3 2006 Acetylcholinesterase inhibitors, such as Physostigmine and Rivastigmine, are considered effective treatments for cognitive decline in Alzheimer"s Disease, where the loss of cholinergic neurons is thought to be responsible for various cognitive deficits. Rivastigmine 59-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 16730341-6 2006 The time course of ACh-dependent facilitation overlaps the developmental maturation of acetylcholinesterase (AChE), suggesting a close relationship between ACh action and AChE activity. Acetylcholine 19-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 16730341-6 2006 The time course of ACh-dependent facilitation overlaps the developmental maturation of acetylcholinesterase (AChE), suggesting a close relationship between ACh action and AChE activity. Acetylcholine 19-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 16730341-6 2006 The time course of ACh-dependent facilitation overlaps the developmental maturation of acetylcholinesterase (AChE), suggesting a close relationship between ACh action and AChE activity. Acetylcholine 19-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 16730341-6 2006 The time course of ACh-dependent facilitation overlaps the developmental maturation of acetylcholinesterase (AChE), suggesting a close relationship between ACh action and AChE activity. Acetylcholine 109-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 16730341-6 2006 The time course of ACh-dependent facilitation overlaps the developmental maturation of acetylcholinesterase (AChE), suggesting a close relationship between ACh action and AChE activity. Acetylcholine 109-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 16456188-6 2006 Eosinophils also induced the expression of several cholinergic genes involved in the synthesis, storage, and metabolism of acetylcholine, including the enzymes choline acetyltransferase, vesicular acetylcholine transferase, and acetylcholinesterase. Acetylcholine 123-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-248 16574369-4 2006 In contrast, a significant decrease in (125)I-alphaBTX binding was detected in the adrenal medulla of 10 months old APP(SWE)/hAChE-Tg. alphabtx 46-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-130 16639719-2 2006 In this review, the most important enzymes (e.g., paraoxonase, carboxylesterase, acetylcholinesterase, cholinesterase) involved in the bioconversion of ester-based prodrugs will be discussed in terms of their biology and biochemistry. Esters 71-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 16623863-10 2006 The similarity in reactivation was caused by analogous chemical structure of either nerve agent; and that oxime HI-6 seems to be the most effective reactivator tested, which confirms that HI-6 is currently the most potent reactivator of AChE inhibited by nerve agents. oxime hi-6 106-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 237-241 16599539-4 2006 It is also revealed that the catalytic triad of acetylcholinesterase plays the catalytic role in the reaction by speeding up the phosphonylation process, as it does in the acylation reaction of ACh and AChE. Acetylcholine 194-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 16772751-1 2006 Inhibitors of the enzyme acetylcholinesterase (AChE) are presently used as long-term symptomatic treatments for patients with Alzheimer disease (AD), as they enhance central levels of synaptic acetylcholine. Acetylcholine 25-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 16789426-0 2006 Inhibition of acetylcholinesterase by two arylderivatives: 3a-Acetoxy-5H-pyrrolo (1,2-a) (3, 1)benzoxazin- 1,5-(3aH)-dione and cis-N-p-Acetoxy-phenylisomaleimide. 3a-acetoxy-5H-pyrrolo(1,2-a)(3,1)benzoxazin-1,5-(3aH)-dione 59-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 16789426-0 2006 Inhibition of acetylcholinesterase by two arylderivatives: 3a-Acetoxy-5H-pyrrolo (1,2-a) (3, 1)benzoxazin- 1,5-(3aH)-dione and cis-N-p-Acetoxy-phenylisomaleimide. cis-n-p-acetoxy-phenylisomaleimide 127-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 16631094-6 2006 This method could be applied to the analysis of [11C]MP4A, useful PET radiopharmaceutical for measuring acetylcholinesterase activity in the brain with no available UV absorbance. Carbon-11 49-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 16403852-0 2006 Concentration-dependent kinetics of acetylcholinesterase inhibition by the organophosphate paraoxon. organophosphate paraoxon 75-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 16403852-1 2006 For decades the interaction of the anticholinesterase organophosphorus compounds with acetylcholinesterase has been characterized as a straightforward phosphylation of the active site serine (Ser-203) which can be described kinetically by the inhibitory rate constant k(i). organophosphorus 54-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 16403852-1 2006 For decades the interaction of the anticholinesterase organophosphorus compounds with acetylcholinesterase has been characterized as a straightforward phosphylation of the active site serine (Ser-203) which can be described kinetically by the inhibitory rate constant k(i). Serine 184-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 16403852-1 2006 For decades the interaction of the anticholinesterase organophosphorus compounds with acetylcholinesterase has been characterized as a straightforward phosphylation of the active site serine (Ser-203) which can be described kinetically by the inhibitory rate constant k(i). Serine 192-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 16403852-2 2006 However, more recently certain kinetic complexities in the inhibition of acetylcholinesterase by organophosphates such as paraoxon (O,O-diethyl O-(p-nitrophenyl) phosphate) and chlorpyrifos oxon (O,O-diethyl O-(3,5,6-trichloro-2-pyridyl) phosphate) have raised questions regarding the adequacy of the kinetic scheme on which k(i) is based. Organophosphates 97-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 16403852-2 2006 However, more recently certain kinetic complexities in the inhibition of acetylcholinesterase by organophosphates such as paraoxon (O,O-diethyl O-(p-nitrophenyl) phosphate) and chlorpyrifos oxon (O,O-diethyl O-(3,5,6-trichloro-2-pyridyl) phosphate) have raised questions regarding the adequacy of the kinetic scheme on which k(i) is based. paraoxon (o,o-diethyl o-(p-nitrophenyl) phosphate) 122-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 16403852-2 2006 However, more recently certain kinetic complexities in the inhibition of acetylcholinesterase by organophosphates such as paraoxon (O,O-diethyl O-(p-nitrophenyl) phosphate) and chlorpyrifos oxon (O,O-diethyl O-(3,5,6-trichloro-2-pyridyl) phosphate) have raised questions regarding the adequacy of the kinetic scheme on which k(i) is based. chlorpyrifos oxon (o,o-diethyl o-(3,5,6-trichloro-2-pyridyl) phosphate 177-247 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 16403852-3 2006 The present article documents conditions in which the inhibitory capacity of paraoxon towards human recombinant acetylcholinesterase appears to change as a function of oxon concentration (as evidenced by a changing k(i)), with the inhibitory capacity of individual oxon molecules increasing at lower oxon concentrations. Paraoxon 77-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 16549835-1 2006 PURPOSE: A prospective, open-label phase II study was conducted to determine whether donepezil, a US Food and Drug Administration-approved reversible acetylcholinesterase inhibitor used to treat mild to moderate Alzheimer"s type dementia, improved cognitive functioning, mood, and quality of life (QOL) in irradiated brain tumor patients. Donepezil 85-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 16549835-10 2006 CONCLUSION: Cognitive functioning, mood, and health-related QOL were significantly improved following a 24-week course of the acetylcholinesterase inhibitor donepezil. Donepezil 157-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 16169212-3 2006 Acetylcholinesterase (AChE) and choline oxidase (ChO) were immobilized by glutaraldehyde co-crosslinking with bovine serum albumin. Glutaral 74-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 16169212-3 2006 Acetylcholinesterase (AChE) and choline oxidase (ChO) were immobilized by glutaraldehyde co-crosslinking with bovine serum albumin. Glutaral 74-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 16169212-9 2006 100 nM for both ACh and Ch at the ChO-AChE electrode and ca. Acetylcholine 16-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 16289855-1 2006 Tetracyclic nitrogen bridgehead compounds, dibenzodiazecines and tricyclic quinazolinimines, in which the size of the alicyclic ring system and the length of the alkyl chain between the quinazolinimine moiety and a phenyl ring connected to the imine nitrogen atom were changed systematically, were synthesized and their ability to inhibit acetyl- and butyrylcholinesterase (AChE/BChE), respectively, was evaluated. Nitrogen 12-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 374-378 16574032-16 2006 Analysis of response by BuChE genotype suggests that this differential effect may be due to the inhibition of BuChE, in addition to AChE, by rivastigmine. Rivastigmine 141-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 16838488-0 2006 [Synthesis of reactivators of phosphorylated acetylcholinesterase of bis-pyridiniumdialdoxime type with a 3-oxapentane connecting chain and their testing in vitro on a model of the enzyme inhibited by chlorpyrifos and methylchlorpyrifos]. bis-pyridiniumdialdoxime 69-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 16838488-0 2006 [Synthesis of reactivators of phosphorylated acetylcholinesterase of bis-pyridiniumdialdoxime type with a 3-oxapentane connecting chain and their testing in vitro on a model of the enzyme inhibited by chlorpyrifos and methylchlorpyrifos]. Ether 106-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 16838488-0 2006 [Synthesis of reactivators of phosphorylated acetylcholinesterase of bis-pyridiniumdialdoxime type with a 3-oxapentane connecting chain and their testing in vitro on a model of the enzyme inhibited by chlorpyrifos and methylchlorpyrifos]. Chlorpyrifos 201-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 16838488-0 2006 [Synthesis of reactivators of phosphorylated acetylcholinesterase of bis-pyridiniumdialdoxime type with a 3-oxapentane connecting chain and their testing in vitro on a model of the enzyme inhibited by chlorpyrifos and methylchlorpyrifos]. chlorpyrifos-methyl 218-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 16838488-6 2006 On the other hand, the known reactivators surpass new substances in the case of chlorpyrifos-inhibited AChE at both concentrations. Chlorpyrifos 80-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 16307468-1 2006 Acetylcholinesterase (AChE) reactivators are employed for the prophylaxis and treatment of intoxications with organophosphorus AChE inhibitors, including nerve agents and pesticides. organophosphorus 110-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 16307468-1 2006 Acetylcholinesterase (AChE) reactivators are employed for the prophylaxis and treatment of intoxications with organophosphorus AChE inhibitors, including nerve agents and pesticides. organophosphorus 110-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 16307468-1 2006 Acetylcholinesterase (AChE) reactivators are employed for the prophylaxis and treatment of intoxications with organophosphorus AChE inhibitors, including nerve agents and pesticides. organophosphorus 110-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 16579834-1 2006 Because brain extracellular acetylcholine (ACh) levels are near detection limits in microdialysis samples, an acetylcholinesterase (AChE) inhibitor such as neostigmine is often added to microdialysis perfusates to increase ACh levels in the dialysate, a practice that raises concerns that the inhibitor might alter the results. Neostigmine 156-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 16579834-1 2006 Because brain extracellular acetylcholine (ACh) levels are near detection limits in microdialysis samples, an acetylcholinesterase (AChE) inhibitor such as neostigmine is often added to microdialysis perfusates to increase ACh levels in the dialysate, a practice that raises concerns that the inhibitor might alter the results. Neostigmine 156-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 16579834-1 2006 Because brain extracellular acetylcholine (ACh) levels are near detection limits in microdialysis samples, an acetylcholinesterase (AChE) inhibitor such as neostigmine is often added to microdialysis perfusates to increase ACh levels in the dialysate, a practice that raises concerns that the inhibitor might alter the results. Acetylcholine 132-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 16249029-3 2006 Here, we report that thapsigargin-induced intracellular Ca(++) release suppressed pre-miR-181a levels in human promegakaryotic Meg-01 cells, induced differentiation-associated nuclear endoreduplication and caspase-3 activation and replaced the acetylcholinesterase 3" splice variant AChE-S with AChE-R. AChE, PKC and PKA inhibitors all attenuated the pre-miR-181a decline and the induced differentiation. Thapsigargin 21-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 283-287 16249029-3 2006 Here, we report that thapsigargin-induced intracellular Ca(++) release suppressed pre-miR-181a levels in human promegakaryotic Meg-01 cells, induced differentiation-associated nuclear endoreduplication and caspase-3 activation and replaced the acetylcholinesterase 3" splice variant AChE-S with AChE-R. AChE, PKC and PKA inhibitors all attenuated the pre-miR-181a decline and the induced differentiation. Thapsigargin 21-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 295-299 16249029-3 2006 Here, we report that thapsigargin-induced intracellular Ca(++) release suppressed pre-miR-181a levels in human promegakaryotic Meg-01 cells, induced differentiation-associated nuclear endoreduplication and caspase-3 activation and replaced the acetylcholinesterase 3" splice variant AChE-S with AChE-R. AChE, PKC and PKA inhibitors all attenuated the pre-miR-181a decline and the induced differentiation. Thapsigargin 21-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 295-299 16516896-2 2006 AChE activity of sample components is monitored by a post-column biochemical assay that is based on the separate, sequential mixing of AChE and acetylcholine, respectively, with the HPLC eluate. Acetylcholine 144-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 16516896-3 2006 AChE inhibitors are detected by measuring a decrease of product formation using electrospray MS. Ammonium bicarbonate was used as buffer in order to achieve optimum compatibility between biochemical assay and MS detection conditions. ammonium bicarbonate 97-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 16483771-1 2006 Several bisbenzylisoquinoline alkaloid derivatives showed the inhibitory activity at acetylcholinesterase enzyme (AChE) in micromolar range. bisbenzylisoquinoline alkaloid 8-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-112 16483771-1 2006 Several bisbenzylisoquinoline alkaloid derivatives showed the inhibitory activity at acetylcholinesterase enzyme (AChE) in micromolar range. bisbenzylisoquinoline alkaloid 8-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 16483771-2 2006 It is possible that monomeric moiety of bisbenzylisoquinoline alkaloid might be required for acetylcholinesterase enzyme inhibition. bisbenzylisoquinoline alkaloid 40-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-120 16483771-3 2006 AChE inhibitory activity of related monomeric 1-benzylisoquinolines was examined by using Ellman colorimetric assay with galanthamine as a reference standard. 1-benzylisoquinolines 46-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 16483771-3 2006 AChE inhibitory activity of related monomeric 1-benzylisoquinolines was examined by using Ellman colorimetric assay with galanthamine as a reference standard. Galantamine 121-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 16683594-9 2006 The pH change is sufficient explanation for the observed inhibition of acetylcholinesterase that was previously attributed to hexafluorosilicate hydrolysis intermediates. hexafluorosilicate 126-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 16570913-5 2006 In addition, a probable transition-state model was established according to the known X-ray structure of a transition-state complex of Torpedo californica AChE-m-(N,N,N-trimethylammonio)-2,2,2-trifluoroacetophenone (TcAChE-TMTFA). tcache-tmtfa 216-228 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 16680189-6 2006 AchE levels were found to be significantly lower in organophosphorus (OP) and carbamated (CB) insecticide poisoning groups in comparison with the control group (p<0.001), while the pyrethroid (PY) group was not statistically different for the AchE effect (p>0.05). organophosphorus 52-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 16680189-6 2006 AchE levels were found to be significantly lower in organophosphorus (OP) and carbamated (CB) insecticide poisoning groups in comparison with the control group (p<0.001), while the pyrethroid (PY) group was not statistically different for the AchE effect (p>0.05). carbamated 78-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 16623863-3 2006 Oximes counteract acetylcholine increase, resulting from AChE inhibition. Oximes 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 16623863-3 2006 Oximes counteract acetylcholine increase, resulting from AChE inhibition. Acetylcholine 18-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 16623863-6 2006 The usefulness of oxime in the reactivation process depends on its chemical structure and on the nerve agent whereby AChE is inhibited. Oximes 18-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 16633145-1 2006 BACKGROUND: Galantamine hydrogen bromide (HBr) is a competitive and reversible inhibitor of acetylcholinesterase. galantamine hydrogen bromide 12-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 16633145-1 2006 BACKGROUND: Galantamine hydrogen bromide (HBr) is a competitive and reversible inhibitor of acetylcholinesterase. Hydrobromic Acid 42-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 16515465-2 2006 These compounds inhibit enzyme acetylcholinesterase (AChE, EC 3.1.1.7) via its phosphorylation or phosphonylation at the serine hydroxy group in its active site. Serine 121-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 16515465-2 2006 These compounds inhibit enzyme acetylcholinesterase (AChE, EC 3.1.1.7) via its phosphorylation or phosphonylation at the serine hydroxy group in its active site. Serine 121-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 16515465-5 2006 Anticholinergic drugs block effects of accumulated neurotransmitter acetylcholine at nicotinic and muscarinic receptor sites, while oximes reactivate AChE inhibited by OPCs. Oximes 132-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 16515465-7 2006 Therefore, to find new oximes able to sufficiently reactivate inhibited AChE (regardless of the type of OPCs) is still very important task for medicinal chemistry with the aim to improve the efficacy of antidotal treatment of the acute poisonings mentioned. Oximes 23-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 15982786-1 2006 Using the in vivo enzyme protection-enzyme inhibition method, we visualized the distribution of the intraventricularly and cisternally (cisterna magna) injected ambenonium chloride (Am) bound reversibly to the extracellular acetylcholinesterase enzyme (AChE) in the rabbit brain in order to describe the extracellular flow pathways from the cerebrospinal fluid (CSF). Ambenonium Chloride 161-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 253-257 16518518-5 2006 In addition, during the course of these excitatory processes and inhibition of AChE, a high rate of ATP consumption, coupled with the inhibition of oxidative phosphorylation, compromise the cell"s ability to maintain its energy levels and excessive amounts of ROS and RNS may be generated. Adenosine Triphosphate 100-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 16518518-5 2006 In addition, during the course of these excitatory processes and inhibition of AChE, a high rate of ATP consumption, coupled with the inhibition of oxidative phosphorylation, compromise the cell"s ability to maintain its energy levels and excessive amounts of ROS and RNS may be generated. Reactive Oxygen Species 260-263 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 16518518-5 2006 In addition, during the course of these excitatory processes and inhibition of AChE, a high rate of ATP consumption, coupled with the inhibition of oxidative phosphorylation, compromise the cell"s ability to maintain its energy levels and excessive amounts of ROS and RNS may be generated. Reactive Nitrogen Species 268-271 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 16518518-6 2006 Pretreatment with N-methyl D-aspartate (NMDA) receptor antagonist memantine, in combination with atropine sulfate, provides significant protection against inhibition of AChE, increases of ROS/RNS, and depletion of high-energy phosphates induced by DFP/carbofuran. Memantine 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 16518518-6 2006 Pretreatment with N-methyl D-aspartate (NMDA) receptor antagonist memantine, in combination with atropine sulfate, provides significant protection against inhibition of AChE, increases of ROS/RNS, and depletion of high-energy phosphates induced by DFP/carbofuran. Atropine 97-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 16495395-2 2006 We assessed the efficacy of itopride, a dopamine D2 antagonist with anti-acetylcholinesterase [corrected] effects, in patients with functional dyspepsia. itopride 28-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 16448058-1 2006 A highly sensitive flow injection amperometric biosensor for organophosphate pesticides and nerve agents based on self-assembled acetylcholinesterase (AChE) on a carbon nanotube (CNT)-modified glassy carbon (GC) electrode is described. Organophosphates 61-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 16448058-1 2006 A highly sensitive flow injection amperometric biosensor for organophosphate pesticides and nerve agents based on self-assembled acetylcholinesterase (AChE) on a carbon nanotube (CNT)-modified glassy carbon (GC) electrode is described. Carbon 162-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 16448058-1 2006 A highly sensitive flow injection amperometric biosensor for organophosphate pesticides and nerve agents based on self-assembled acetylcholinesterase (AChE) on a carbon nanotube (CNT)-modified glassy carbon (GC) electrode is described. Carbon 200-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 16448058-2 2006 AChE is immobilized on the negatively charged CNT surface by alternatively assembling a cationic poly(diallyldimethylammonium chloride) (PDDA) layer and an AChE layer. poly-N,N-dimethyl-N,N-diallylammonium chloride 97-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 16448058-2 2006 AChE is immobilized on the negatively charged CNT surface by alternatively assembling a cationic poly(diallyldimethylammonium chloride) (PDDA) layer and an AChE layer. poly-N,N-dimethyl-N,N-diallylammonium chloride 137-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 16448058-7 2006 The developed PDDA/AChE/PDDA/CNT/GC biosensor integrated into a flow injection system was used to monitor organophosphate pesticides and nerve agents, such as paraoxon. Organophosphates 106-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 16448058-7 2006 The developed PDDA/AChE/PDDA/CNT/GC biosensor integrated into a flow injection system was used to monitor organophosphate pesticides and nerve agents, such as paraoxon. Paraoxon 159-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 16288867-2 2006 Their potency to reactivate AChE inhibited by insecticide chlorpyrifos was tested in vitro. Chlorpyrifos 58-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 16288867-3 2006 According to the results, (E)-1-(2-hydroxyiminomethylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide seems to be the most potent AChE reactivator. (E)-1-(2-hydroxyiminomethylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide 26-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 16485896-0 2006 Mechanistic insight into acetylcholinesterase inhibition and acute toxicity of organophosphorus compounds: a molecular modeling study. organophosphorus 79-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 16485896-1 2006 Acute toxicity of organophosphorus (OP) compounds results mainly from irreversible acetylcholinesterase (AChE) inhibition; however OP toxicity frequently hinges on prior biotransformations that produce toxic metabolites. organophosphorus 18-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 16485896-1 2006 Acute toxicity of organophosphorus (OP) compounds results mainly from irreversible acetylcholinesterase (AChE) inhibition; however OP toxicity frequently hinges on prior biotransformations that produce toxic metabolites. organophosphorus 18-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 16485911-0 2006 Aging of mipafox-inhibited human acetylcholinesterase proceeds by displacement of both isopropylamine groups to yield a phosphate adduct. mipafox 9-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 16485911-0 2006 Aging of mipafox-inhibited human acetylcholinesterase proceeds by displacement of both isopropylamine groups to yield a phosphate adduct. 2-propylamine 87-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 16485911-0 2006 Aging of mipafox-inhibited human acetylcholinesterase proceeds by displacement of both isopropylamine groups to yield a phosphate adduct. Phosphates 120-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 16485911-9 2006 In contrast, the analogous mass shift for kinetically aged MIP-inhibited AChE was 80.7 +/- 0.9 Da, corresponding to a phosphate adduct. Phosphates 118-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 16485911-11 2006 The results indicate that aging of MIP-inhibited AChE proceeds by displacement of both isopropylamine groups. 2-propylamine 87-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 16485911-12 2006 Further research will be required to elucidate the detailed mechanism of formation of a phosphate conjugate from MIP-inhibited AChE; however, knowledge of the identity of this adduct will be useful in biomarker studies. Phosphates 88-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 16481671-2 2006 Because work in dementia documents improvement in executive function deficits with the acetylcholinesterase inhibitor donepezil, the authors reason that similar benefits could be obtained in PDD. Donepezil 118-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 16570502-0 2006 Syntheses and spectroscopic characterization of some phosphoramidates as reversible inhibitors of human acetylcholinesterase and determination of their potency. phosphoramidic acid 53-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 16570513-3 2006 Unexpectedly, it was observed that they were not only hydrolytically unstable but also inhibited hAChE in a similar manner to that produced by organophosphorus insecticides. organophosphorus 143-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-102 16341717-2 2006 Among the great variety of crystal structures of this enzyme, both in the absence and presence of various ligands and proteins, the structure of a complex of AChE with the pseudo-irreversible inhibitor Mf268 is of particular interest, as it assists in the proposal of a back door for product clearance from the active site. MF 268 202-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 16341717-3 2006 Binding of Mf268 to AChE results in the carbamoylation of Ser200 and liberation of an eseroline-fragment as the leaving group. MF 268 11-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 16341717-3 2006 Binding of Mf268 to AChE results in the carbamoylation of Ser200 and liberation of an eseroline-fragment as the leaving group. eseroline 86-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 16341717-4 2006 The crystal structure of the AChE-Mf268 complex, however, proves that eseroline has escaped from the enzyme, despite the fact that the Ser-bound inhibitor fragment blocks the gorge entrance. MF 268 34-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 16341717-4 2006 The crystal structure of the AChE-Mf268 complex, however, proves that eseroline has escaped from the enzyme, despite the fact that the Ser-bound inhibitor fragment blocks the gorge entrance. eseroline 70-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 16341717-4 2006 The crystal structure of the AChE-Mf268 complex, however, proves that eseroline has escaped from the enzyme, despite the fact that the Ser-bound inhibitor fragment blocks the gorge entrance. Serine 135-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 16133720-2 2006 In this study we determined cognitive correlates of in vivo cortical AChE activity in patients with parkinsonian dementia (PDem, n = 11), Parkinson"s disease without dementia (PD, n = 13), and in normal controls (NC, n = 14) using N-[(11)C]methyl-piperidin-4-yl propionate ([(11)C]PMP) AChE positron emission tomography (PET). methyl-piperidin-4-yl propionate 240-272 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 16133720-2 2006 In this study we determined cognitive correlates of in vivo cortical AChE activity in patients with parkinsonian dementia (PDem, n = 11), Parkinson"s disease without dementia (PD, n = 13), and in normal controls (NC, n = 14) using N-[(11)C]methyl-piperidin-4-yl propionate ([(11)C]PMP) AChE positron emission tomography (PET). 2-(4-methoxyphenoxy)propanoic acid 281-284 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 16503777-1 2006 Donepezil, a selective acetylcholinesterase (AChE) inhibitor, has been shown to reduce intraocular pressure (IOP) in ocular normotensive rabbit eyes. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 16503777-1 2006 Donepezil, a selective acetylcholinesterase (AChE) inhibitor, has been shown to reduce intraocular pressure (IOP) in ocular normotensive rabbit eyes. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 16503777-8 2006 These findings show that donepezil, and, possibly, other selective AChE inhibitors, can potentially be used to treat glaucoma. Donepezil 25-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 16601937-3 2006 For one month we studied the effects of donepezil, an acetylcholinesterase inhibitor (5 mg daily), on the cognitive system using P300 auditory event-related potentials (P300) and neuropsychological tests in 10 patients affected by probable VaD according to the NINDS-AIREN criteria. Donepezil 40-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 16671539-0 2006 [Synthesis and AchE inhibitory activity of 2-phenoxy-indan-1-one derivatives]. 2-phenoxy-indan-1-one 43-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 16671539-2 2006 METHODS: The condensation of 2-bromo-5, 6-dimethoxy-indan-1-one with various aminoalkyl phenols in the presence of K2CO3 and acetonitrile gave the corresponding title compounds, and the in vitro AchE and BchE inhibitory activities were evaluated by the modified Ellman method. 2-bromo-5, 6-dimethoxy-indan-1-one 29-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 16671539-2 2006 METHODS: The condensation of 2-bromo-5, 6-dimethoxy-indan-1-one with various aminoalkyl phenols in the presence of K2CO3 and acetonitrile gave the corresponding title compounds, and the in vitro AchE and BchE inhibitory activities were evaluated by the modified Ellman method. aminoalkyl phenols 77-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 16671539-2 2006 METHODS: The condensation of 2-bromo-5, 6-dimethoxy-indan-1-one with various aminoalkyl phenols in the presence of K2CO3 and acetonitrile gave the corresponding title compounds, and the in vitro AchE and BchE inhibitory activities were evaluated by the modified Ellman method. potassium carbonate 115-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 16671539-2 2006 METHODS: The condensation of 2-bromo-5, 6-dimethoxy-indan-1-one with various aminoalkyl phenols in the presence of K2CO3 and acetonitrile gave the corresponding title compounds, and the in vitro AchE and BchE inhibitory activities were evaluated by the modified Ellman method. acetonitrile 125-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 16671539-5 2006 CONCLUSION: 2-Phenoxy-indan-1-one derivatives exhibit high activities of AchE inhibition and are worthy of further investigation. 2-phenoxy-indan-1-one 12-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 16420031-0 2006 Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties. Tacrine 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 16420031-0 2006 Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties. Melatonin 14-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 16420031-1 2006 Tacrine and melatonin are well-known drugs with activities as an acetylcholinesterase (AChE) inhibitor and free radical scavenger, respectively. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 16420031-1 2006 Tacrine and melatonin are well-known drugs with activities as an acetylcholinesterase (AChE) inhibitor and free radical scavenger, respectively. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 16420031-1 2006 Tacrine and melatonin are well-known drugs with activities as an acetylcholinesterase (AChE) inhibitor and free radical scavenger, respectively. Melatonin 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 16420031-1 2006 Tacrine and melatonin are well-known drugs with activities as an acetylcholinesterase (AChE) inhibitor and free radical scavenger, respectively. Melatonin 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 16240314-0 2006 Binding of acetylcholinesterase to multiwall carbon nanotube-cross-linked chitosan composite for flow-injection amperometric detection of an organophosphorous insecticide. Carbon 45-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 16240314-0 2006 Binding of acetylcholinesterase to multiwall carbon nanotube-cross-linked chitosan composite for flow-injection amperometric detection of an organophosphorous insecticide. organophosphorous 141-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 16240314-1 2006 A novel method for immobilization of acetylcholinesterase (AChE) by binding covalently to a cross-linked chitosan-multiwall carbon nanotube (MWNT) composite is described. Carbon 124-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 16240314-1 2006 A novel method for immobilization of acetylcholinesterase (AChE) by binding covalently to a cross-linked chitosan-multiwall carbon nanotube (MWNT) composite is described. Carbon 124-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 16240314-4 2006 The immobilized AChE could catalyze the hydrolysis of acetylthiocholine with a K(M)app value of 177 microM to form thiocholine, which was then oxidized to produce detectable signal in a linear range of 1.0-500 microM and fast response. Acetylthiocholine 54-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 16240314-4 2006 The immobilized AChE could catalyze the hydrolysis of acetylthiocholine with a K(M)app value of 177 microM to form thiocholine, which was then oxidized to produce detectable signal in a linear range of 1.0-500 microM and fast response. Thiocholine 60-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 16240314-6 2006 Based on the inhibition of an organophosphorous insecticide on the enzymatic activity of AChE, using Sulfotep as a model compound, the conditions for the flow-injection detection of the insecticide were optimized. organophosphorous 30-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 16240314-6 2006 Based on the inhibition of an organophosphorous insecticide on the enzymatic activity of AChE, using Sulfotep as a model compound, the conditions for the flow-injection detection of the insecticide were optimized. sulfotepp 101-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 16240314-8 2006 95 % reactivation from inhibited AChE could be regenerated by using 2-pyridinealdoxime methiodide within 15 min for 15 times. pralidoxime iodide 68-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 16198581-0 2006 Search for dual function inhibitors for Alzheimer"s disease: synthesis and biological activity of acetylcholinesterase inhibitors of pyridinium-type and their Abeta fibril formation inhibition capacity. pyridine 133-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-118 16198581-4 2006 [Scarpini, E.; Scheltens, P.; Feldman, H. Lancet Neurol.2003, 2, 539] In view of the development of new AChE inhibitors as drugs capable of reducing the symptoms of AD, the capacity of newly synthesized AChE inhibitors of pyridinium-type to inhibit the AChE was examined and compared to those of other inhibitors of this type presented earlier. pyridine 222-232 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 16198581-10 2006 Pharmacol.2003, 55, 1397] Furthermore, the anti-Abeta fibril formation property of AChE inhibitors of pyridinium- and bispyridinium-type was evaluated to expand their activity profile and to reveal potential additive pharmacological effects which may reinforce their therapeutic application besides their capacity of increasing acetylcholine levels. pyridine 102-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 16198581-10 2006 Pharmacol.2003, 55, 1397] Furthermore, the anti-Abeta fibril formation property of AChE inhibitors of pyridinium- and bispyridinium-type was evaluated to expand their activity profile and to reveal potential additive pharmacological effects which may reinforce their therapeutic application besides their capacity of increasing acetylcholine levels. bispyridinium 118-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 16198581-10 2006 Pharmacol.2003, 55, 1397] Furthermore, the anti-Abeta fibril formation property of AChE inhibitors of pyridinium- and bispyridinium-type was evaluated to expand their activity profile and to reveal potential additive pharmacological effects which may reinforce their therapeutic application besides their capacity of increasing acetylcholine levels. Acetylcholine 328-341 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 16181792-2 2006 In a randomized, placebo-controlled, double-blind, parallel-group design, we investigated the neural correlates of cognitive effects of rivastigmine, an acetylcholinesterase inhibitor, given as an add-on therapy to antipsychotic-treated schizophrenia patients. Rivastigmine 136-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-173 16256972-7 2006 Furthermore, activity of AChE, but not NTE, was significantly inhibited by aldicarb and carbaryl in differentiating cells, which suggested that cytoskeletal protein changes induced by carbamate esters in differentiating cells was associated with inhibition of AChE but not NTE. Aldicarb 75-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 16256972-7 2006 Furthermore, activity of AChE, but not NTE, was significantly inhibited by aldicarb and carbaryl in differentiating cells, which suggested that cytoskeletal protein changes induced by carbamate esters in differentiating cells was associated with inhibition of AChE but not NTE. Carbaryl 88-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 16256972-7 2006 Furthermore, activity of AChE, but not NTE, was significantly inhibited by aldicarb and carbaryl in differentiating cells, which suggested that cytoskeletal protein changes induced by carbamate esters in differentiating cells was associated with inhibition of AChE but not NTE. Carbaryl 88-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 260-264 16256972-7 2006 Furthermore, activity of AChE, but not NTE, was significantly inhibited by aldicarb and carbaryl in differentiating cells, which suggested that cytoskeletal protein changes induced by carbamate esters in differentiating cells was associated with inhibition of AChE but not NTE. carbamate esters 184-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 16256972-7 2006 Furthermore, activity of AChE, but not NTE, was significantly inhibited by aldicarb and carbaryl in differentiating cells, which suggested that cytoskeletal protein changes induced by carbamate esters in differentiating cells was associated with inhibition of AChE but not NTE. carbamate esters 184-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 260-264 16381583-0 2006 Lycoperine A, A novel C27N3-type pentacyclic alkaloid from Lycopodium hamiltonii, inhibiting acetylcholinesterase. lycoperine A 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 16649535-0 2006 New tacrine-hydrazinonicotinamide hybrids as acetylcholinesterase inhibitors of potential interest for the early diagnostics of Alzheimer"s disease. Tacrine 4-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 16649535-0 2006 New tacrine-hydrazinonicotinamide hybrids as acetylcholinesterase inhibitors of potential interest for the early diagnostics of Alzheimer"s disease. hydrazino nicotinamide 12-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 16649535-1 2006 The syntheses and the preliminary results of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition by an affinity series of tacrine-hydrazinonicotinamide hybrids are described. Tacrine 142-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 16649535-1 2006 The syntheses and the preliminary results of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition by an affinity series of tacrine-hydrazinonicotinamide hybrids are described. Tacrine 142-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 16649535-1 2006 The syntheses and the preliminary results of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition by an affinity series of tacrine-hydrazinonicotinamide hybrids are described. hydrazino nicotinamide 150-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 16649535-1 2006 The syntheses and the preliminary results of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition by an affinity series of tacrine-hydrazinonicotinamide hybrids are described. hydrazino nicotinamide 150-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 16649535-3 2006 Derivatives 6a and 6b showed lower activity than the model tacrine, while compounds 6c and 6d showed the strongest affinity to AChE. Tacrine 59-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 17438836-6 2006 From obtained results, it can be deduced, that only reactivators with oxime group in position two are able to reactivate cyclosarin-inhibited AChE. Oximes 70-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 17438836-6 2006 From obtained results, it can be deduced, that only reactivators with oxime group in position two are able to reactivate cyclosarin-inhibited AChE. cyclohexyl methylphosphonofluoridate 121-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 22500154-2 2006 It is a specific and reversible inhibitor of acetylcholinesterase (AChE); by increasing levels of available acetylcholine, donepezil may compensate for the loss of functioning cholinergic brain cells. Acetylcholine 45-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 22500154-2 2006 It is a specific and reversible inhibitor of acetylcholinesterase (AChE); by increasing levels of available acetylcholine, donepezil may compensate for the loss of functioning cholinergic brain cells. Donepezil 123-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 16193529-0 2006 Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: in vitro reactivation of red blood cell acetylcholinesterase inhibited by paraoxon. Oximes 5-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-143 16193529-0 2006 Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: in vitro reactivation of red blood cell acetylcholinesterase inhibited by paraoxon. N,N'-monomethylenebis(pyridiniumaldoxime) 40-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-143 18221196-5 2006 Galanthamine is a long-acting, selective, reversible and competitive AChE inhibitor that has recently been tested in AD patients and found to be readily absorbed, to be a performance enhancer on memory tests in some patients, and to be well tolerated, although some cholinergic side effects were observed. Galantamine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 17288495-1 2006 The traditional therapeutic treatment of organophosphate cholinesterase inhibitor (nerve agents) poisoning consists of co-treatment with an antimuscarinic (atropine) and a reactivator of inhibited acetylcholinesterase (AChE), which contains a nucleophilic oxime function. Oximes 256-261 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-217 17288495-1 2006 The traditional therapeutic treatment of organophosphate cholinesterase inhibitor (nerve agents) poisoning consists of co-treatment with an antimuscarinic (atropine) and a reactivator of inhibited acetylcholinesterase (AChE), which contains a nucleophilic oxime function. Oximes 256-261 acetylcholinesterase (Cartwright blood group) Homo sapiens 219-223 17288495-10 2006 The article also discusses the possibility of successful therapy with HI-6 against poisoning in humans relative to doses used in non-human primates and relative to its ability to reactivate inhibited human AChE. asoxime chloride 70-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 206-210 17288500-6 2006 Nerve agents phosphonylate a serine hydroxyl group in the active site of the enzyme, acetylcholinesterase (AChE), which results in accumulation of acetylcholine and, in turn, causes enhancement and prolongation of cholinergic effects and depolarisation blockade. phosphonylate 13-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 17288500-6 2006 Nerve agents phosphonylate a serine hydroxyl group in the active site of the enzyme, acetylcholinesterase (AChE), which results in accumulation of acetylcholine and, in turn, causes enhancement and prolongation of cholinergic effects and depolarisation blockade. phosphonylate 13-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 17288500-6 2006 Nerve agents phosphonylate a serine hydroxyl group in the active site of the enzyme, acetylcholinesterase (AChE), which results in accumulation of acetylcholine and, in turn, causes enhancement and prolongation of cholinergic effects and depolarisation blockade. serine hydroxyl 29-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 17288500-6 2006 Nerve agents phosphonylate a serine hydroxyl group in the active site of the enzyme, acetylcholinesterase (AChE), which results in accumulation of acetylcholine and, in turn, causes enhancement and prolongation of cholinergic effects and depolarisation blockade. serine hydroxyl 29-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 17288500-6 2006 Nerve agents phosphonylate a serine hydroxyl group in the active site of the enzyme, acetylcholinesterase (AChE), which results in accumulation of acetylcholine and, in turn, causes enhancement and prolongation of cholinergic effects and depolarisation blockade. Acetylcholine 85-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 17288500-13 2006 As a result, it is important that an oxime is administered as soon after soman exposure as possible so that some reactivation of AChE occurs before all the enzyme becomes aged. Oximes 37-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 20021020-0 2006 Effect of four organophosphorus compounds on human blood acetylcholinesterase: in vitro studies. organophosphorus 15-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 20021020-1 2006 In the present investigation acetylcholinesterase (AChE) was estimated in erythrocytes from blood samples exposed to four commonly used organophosphorus pesticides in vitro. organophosphorus 136-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 20021020-1 2006 In the present investigation acetylcholinesterase (AChE) was estimated in erythrocytes from blood samples exposed to four commonly used organophosphorus pesticides in vitro. organophosphorus 136-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 20021020-2 2006 The aim of the study was to determine the IC50 concentration of the pesticides monocrotophos, chlorpyrifos, profenofos, and acephate as inhibitors of AChE. Monocrotophos 79-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 20021020-2 2006 The aim of the study was to determine the IC50 concentration of the pesticides monocrotophos, chlorpyrifos, profenofos, and acephate as inhibitors of AChE. Chlorpyrifos 94-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 20021020-2 2006 The aim of the study was to determine the IC50 concentration of the pesticides monocrotophos, chlorpyrifos, profenofos, and acephate as inhibitors of AChE. profenofos 108-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 20021020-2 2006 The aim of the study was to determine the IC50 concentration of the pesticides monocrotophos, chlorpyrifos, profenofos, and acephate as inhibitors of AChE. acephate 124-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 20021020-5 2006 The IC50 values for RBC-AChE were 0.12 muM, 0.25 muM, 0.35 muM, and 4.0 muM for chlorpyrifos, monocrotophos, profenofos, and acephate, respectively. Chlorpyrifos 80-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 20021020-5 2006 The IC50 values for RBC-AChE were 0.12 muM, 0.25 muM, 0.35 muM, and 4.0 muM for chlorpyrifos, monocrotophos, profenofos, and acephate, respectively. Monocrotophos 94-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 20021020-5 2006 The IC50 values for RBC-AChE were 0.12 muM, 0.25 muM, 0.35 muM, and 4.0 muM for chlorpyrifos, monocrotophos, profenofos, and acephate, respectively. profenofos 109-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 20021020-5 2006 The IC50 values for RBC-AChE were 0.12 muM, 0.25 muM, 0.35 muM, and 4.0 muM for chlorpyrifos, monocrotophos, profenofos, and acephate, respectively. acephate 125-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 20021020-6 2006 Chlorpyrifos was found to be a more potent inhibitor of AChE followed by the rest of the pesticides used in this study. Chlorpyrifos 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 16366609-0 2005 Synthesis of tricyclic 1,3-oxazin-4-ones and kinetic analysis of cholesterol esterase and acetylcholinesterase inhibition. tricyclic 1,3-oxazin-4-ones 13-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 16366609-1 2005 A series of thieno[1,3]oxazin-4-ones and thieno[1,3]thiazin-4-ones were synthesized and investigated as inhibitors of the alpha/beta hydrolases cholesterol esterase (CEase) and acetylcholinesterase (AChE). thieno[1,3]oxazin-4-ones 12-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-197 16366609-1 2005 A series of thieno[1,3]oxazin-4-ones and thieno[1,3]thiazin-4-ones were synthesized and investigated as inhibitors of the alpha/beta hydrolases cholesterol esterase (CEase) and acetylcholinesterase (AChE). thieno[1,3]thiazin-4-ones 41-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-197 16366609-6 2005 The introduction of a tetrahydropyrido ring with bulky hydrophobic substituents at the basic nitrogen provided inhibitors of AChE which were completely inactive toward CEase. Nitrogen 93-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 16366609-9 2005 To specify kinetic parameters of inhibition, a new method was derived to characterize selected thieno[1,3]oxazin-4-ones as hyperbolic mixed-type inhibitors of AChE. thieno[1,3]oxazin-4-ones 95-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 16337925-1 2005 To examine whether the selected antisense oligodeoxynucleotides (AS-ODN) targeting against human brain acetylcholinesterase (AChE) mRNA could improve the cognitive deficit in the Alzheimer"s disease (AD) model mice induced by amyloid-beta peptide (Abeta), we determined the time-effect relationship of AChE activity and the learning and memory after AS-ODN delivery. Oligodeoxyribonucleotides 42-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 16337925-1 2005 To examine whether the selected antisense oligodeoxynucleotides (AS-ODN) targeting against human brain acetylcholinesterase (AChE) mRNA could improve the cognitive deficit in the Alzheimer"s disease (AD) model mice induced by amyloid-beta peptide (Abeta), we determined the time-effect relationship of AChE activity and the learning and memory after AS-ODN delivery. as-odn 65-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 16230018-0 2005 Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 16230018-0 2005 Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE. Tacrine 10-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 16230018-3 2005 One of the synthesised compounds emerged as a potent and selective AChE inhibitor, which is able to displace propidium in a competition assay. Propidium 109-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 16243304-1 2005 Acetylcholinesterase (AChE) is one of several hundred serine hydrolases in people potentially exposed to about 80 organophosphorus (OP) compounds important as insecticides or chemical warfare agents. organophosphorus 114-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 16243304-1 2005 Acetylcholinesterase (AChE) is one of several hundred serine hydrolases in people potentially exposed to about 80 organophosphorus (OP) compounds important as insecticides or chemical warfare agents. organophosphorus 114-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 16243305-8 2005 Thus, as compared with controls, the amount of A12 AChE in the AD samples was increased 148 and 161% in lymphocytes and platelets, respectively. compound A 12 47-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 16256090-3 2005 Exposure to organophosphate (OP) chemical warfare agents (CWAs), pesticides, anesthetics, and a variety of drugs such as cocaine, as well as some neurodegenerative and liver disease states, selectively reduces AChE or BChE activity. Organophosphates 12-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-214 16256090-3 2005 Exposure to organophosphate (OP) chemical warfare agents (CWAs), pesticides, anesthetics, and a variety of drugs such as cocaine, as well as some neurodegenerative and liver disease states, selectively reduces AChE or BChE activity. Cocaine 121-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-214 16256090-13 2005 We found that maximal inhibition of AChE (26.2%) and concentration of PB (17.1 ng/mL) occurred at 2.5 h post-PB dosing. Lead 109-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 16256090-14 2005 AChE activity returned to almost 100% of pre-dose values by 6 h. A dose-dependent linear correlation was found between the amount of PB measured in the blood and the inhibition of AChE. Lead 133-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 16256090-14 2005 AChE activity returned to almost 100% of pre-dose values by 6 h. A dose-dependent linear correlation was found between the amount of PB measured in the blood and the inhibition of AChE. Lead 133-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 16256090-18 2005 Huperzine A is a plant-derived reversible and selective AChE inhibitor compared to BChE, and is a more potent inhibitor of AChE than PB. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 16256090-18 2005 Huperzine A is a plant-derived reversible and selective AChE inhibitor compared to BChE, and is a more potent inhibitor of AChE than PB. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 16256090-20 2005 Individuals received an increasing dose regimen of huperzine A (final dose 200 microg after 4 weeks), which produced more than 50% inhibition of RBC-AChE. huperzine A 51-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 16256090-21 2005 Huperzine A was well tolerated by these patients at doses that sequestered more RBC-AChE than PB, and thus warrants further study as a prophylaxis for OP poisoning in addition to Alzheimer"s therapy. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 16256966-1 2005 Acetylcholinesterase (AChE) hydrolyzes its physiological substrate acetylcholine at one of the highest known catalytic rates. Acetylcholine 67-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 16256966-1 2005 Acetylcholinesterase (AChE) hydrolyzes its physiological substrate acetylcholine at one of the highest known catalytic rates. Acetylcholine 67-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 16256966-7 2005 To investigate this point, we have measured the reaction of carbamoyl esters (carbamates) with AChE. carbamoyl esters 60-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 16256966-7 2005 To investigate this point, we have measured the reaction of carbamoyl esters (carbamates) with AChE. Carbamates 78-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 16257398-0 2005 Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11. Irinotecan 61-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 16257398-6 2005 Kinetic studies indicated that CPT-11 was primarily responsible for AChE inhibition with the 4-piperidinopiperidine moiety, the major determinant in the loss of enzyme activity. Irinotecan 31-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 16257398-8 2005 These results suggest that novel anticancer drugs could be synthesized that do not inhibit AChE, or alternatively, that novel AChE inhibitors could be designed based around the camptothecin scaffold. Camptothecin 177-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 16263103-7 2005 Accordingly, RBC-AChE appears to be a suitable parameter for judgment of oxime effectiveness at the neuromuscular junction, one of the most important targets for therapy where atropine is ineffective in OP-poisoning. Oximes 73-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 16266695-1 2005 Standard treatment of poisoning by organophosphorus compounds (OP) includes the administration of an anti-muscarinic, e.g. atropine, and of an acetylcholinesterase (AChE) reactivator (oxime). Organophosphorus Compounds 35-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 16266695-1 2005 Standard treatment of poisoning by organophosphorus compounds (OP) includes the administration of an anti-muscarinic, e.g. atropine, and of an acetylcholinesterase (AChE) reactivator (oxime). Oximes 184-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 16266695-1 2005 Standard treatment of poisoning by organophosphorus compounds (OP) includes the administration of an anti-muscarinic, e.g. atropine, and of an acetylcholinesterase (AChE) reactivator (oxime). Oximes 184-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 16266695-7 2005 Reactivation of inhibited AChE is considered to be the main mechanism of action of oximes. Oximes 83-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 16266695-8 2005 Clinical data indicate that changes in erythrocyte AChE activity correlate to neuromuscular function indicating that interactions between AChE, inhibitor and oximes can be investigated in vitro with human erythrocyte AChE. Oximes 158-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 16266695-8 2005 Clinical data indicate that changes in erythrocyte AChE activity correlate to neuromuscular function indicating that interactions between AChE, inhibitor and oximes can be investigated in vitro with human erythrocyte AChE. Oximes 158-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 16266695-8 2005 Clinical data indicate that changes in erythrocyte AChE activity correlate to neuromuscular function indicating that interactions between AChE, inhibitor and oximes can be investigated in vitro with human erythrocyte AChE. Oximes 158-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 16266695-9 2005 Different theoretical models were used for the evaluation of reactivating efficacy of oximes with nerve agent-inhibited human AChE and for estimating effective oxime concentrations. Oximes 86-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 16266695-9 2005 Different theoretical models were used for the evaluation of reactivating efficacy of oximes with nerve agent-inhibited human AChE and for estimating effective oxime concentrations. Oximes 86-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 16293236-1 2005 Current antidotes for organophosphorus compounds (OP) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetylcholinesterase (AChE) from irreversible inhibition by OP compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-PAM chloride) to reactivate OP-inhibited AChE. Organophosphorus Compounds 22-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-178 16293236-1 2005 Current antidotes for organophosphorus compounds (OP) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetylcholinesterase (AChE) from irreversible inhibition by OP compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-PAM chloride) to reactivate OP-inhibited AChE. Organophosphorus Compounds 22-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 16293236-1 2005 Current antidotes for organophosphorus compounds (OP) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetylcholinesterase (AChE) from irreversible inhibition by OP compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-PAM chloride) to reactivate OP-inhibited AChE. Organophosphorus Compounds 22-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 416-420 16293236-1 2005 Current antidotes for organophosphorus compounds (OP) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetylcholinesterase (AChE) from irreversible inhibition by OP compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-PAM chloride) to reactivate OP-inhibited AChE. Carbamates 110-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-178 16293236-1 2005 Current antidotes for organophosphorus compounds (OP) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetylcholinesterase (AChE) from irreversible inhibition by OP compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-PAM chloride) to reactivate OP-inhibited AChE. Carbamates 110-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 16293236-1 2005 Current antidotes for organophosphorus compounds (OP) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetylcholinesterase (AChE) from irreversible inhibition by OP compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-PAM chloride) to reactivate OP-inhibited AChE. Pyridostigmine Bromide 122-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-178 16293236-1 2005 Current antidotes for organophosphorus compounds (OP) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetylcholinesterase (AChE) from irreversible inhibition by OP compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-PAM chloride) to reactivate OP-inhibited AChE. Pyridostigmine Bromide 122-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 16293236-1 2005 Current antidotes for organophosphorus compounds (OP) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetylcholinesterase (AChE) from irreversible inhibition by OP compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-PAM chloride) to reactivate OP-inhibited AChE. Pyridostigmine Bromide 122-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 416-420 16293236-1 2005 Current antidotes for organophosphorus compounds (OP) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetylcholinesterase (AChE) from irreversible inhibition by OP compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-PAM chloride) to reactivate OP-inhibited AChE. Atropine 287-303 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 16293236-1 2005 Current antidotes for organophosphorus compounds (OP) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetylcholinesterase (AChE) from irreversible inhibition by OP compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-PAM chloride) to reactivate OP-inhibited AChE. Acetylcholine 158-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 16293236-1 2005 Current antidotes for organophosphorus compounds (OP) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetylcholinesterase (AChE) from irreversible inhibition by OP compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-PAM chloride) to reactivate OP-inhibited AChE. Oximes 359-365 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 16293236-1 2005 Current antidotes for organophosphorus compounds (OP) poisoning consist of a combination of pretreatment with carbamates (pyridostigmine bromide), to protect acetylcholinesterase (AChE) from irreversible inhibition by OP compounds, and post-exposure therapy with anti-cholinergic drugs (atropine sulfate) to counteract the effects of excess acetylcholine and oximes (e.g., 2-PAM chloride) to reactivate OP-inhibited AChE. pralidoxime 373-387 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 16429489-3 2005 K033 is sufficient reactivator of cyclosarin-inhibited AChE. cyclohexyl methylphosphonofluoridate 34-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 16429502-0 2005 Effects of succinic acid derivatives on ex vivo acetylcholinesterase activity. Succinic Acid 11-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 16429502-2 2005 Administration of a single dose of each of two succinic acid derivatives produced a time and dose-dependent inhibition of brain AChE activity. Succinic Acid 47-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 16429518-0 2005 Comparison of ability of some oximes to reactivate sarin-inhibited brain acetylcholinesterase from different species. Oximes 30-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 16429518-1 2005 The aim of this work was the comparison of reactivation potency of four oxime acetylcholinesterase (AChE) reactivators (pralidoxime, HI-6, K027 and K033) on three resources of the enzyme (human, pig and rat brain homogenate) inhibited by nerve agent sarin. pralidoxime 120-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 16429518-1 2005 The aim of this work was the comparison of reactivation potency of four oxime acetylcholinesterase (AChE) reactivators (pralidoxime, HI-6, K027 and K033) on three resources of the enzyme (human, pig and rat brain homogenate) inhibited by nerve agent sarin. pralidoxime 120-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 16429518-1 2005 The aim of this work was the comparison of reactivation potency of four oxime acetylcholinesterase (AChE) reactivators (pralidoxime, HI-6, K027 and K033) on three resources of the enzyme (human, pig and rat brain homogenate) inhibited by nerve agent sarin. asoxime chloride 133-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 16429518-1 2005 The aim of this work was the comparison of reactivation potency of four oxime acetylcholinesterase (AChE) reactivators (pralidoxime, HI-6, K027 and K033) on three resources of the enzyme (human, pig and rat brain homogenate) inhibited by nerve agent sarin. asoxime chloride 133-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 16429518-2 2005 The results demonstrate remarkable differences in the reactivation of inhibited brain AChE, depending on the oxime and species Oximes 109-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 16429526-0 2005 Acetylcholinesterase mutants: oxime-assisted catalytic scavengers of organophosphonates. Oximes 30-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 16429526-0 2005 Acetylcholinesterase mutants: oxime-assisted catalytic scavengers of organophosphonates. Organophosphonates 69-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 16429565-0 2005 Decalin-type acetylcholine-mimetic organophosphates as inhibitors of acetylcholinesterase. decalin-type acetylcholine-mimetic organophosphates 0-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 16429566-0 2005 The stereochemistry of the inhibition of acetylcholinesterase with acetylcholine-mimetic 7-aza-2,4-dioxaphosphadecalins. 7-aza-2,4-dioxaphosphadecalins 89-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 16429566-1 2005 The irreversible inhibition of acetylcholinesterase with the decalin-type cis- and trans-3-fluoro-2,4-dioxa-7-aza-3-phosphadecalins was investigated by 31P-NMR spectroscopy. 3-fluoro-2,4-dioxa-7-aza-3-phosphadecalins 89-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 16429566-1 2005 The irreversible inhibition of acetylcholinesterase with the decalin-type cis- and trans-3-fluoro-2,4-dioxa-7-aza-3-phosphadecalins was investigated by 31P-NMR spectroscopy. ET bromodomain inhibitor 152-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 16429571-0 2005 ATP induces the post-synaptic gene expression in neuron-neuron synapses: Transcriptional regulation of AChE catalytic subunit. Adenosine Triphosphate 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 16429571-2 2005 The synaptic ATP induces post-synaptic gene transcription during the formation and maintenance of vertebrate neuromuscular junction (nmj) via a mitogen-activaton protein (MAP) kinase signaling pathway and subsequently activates acetylcholinesterase (AChE) and acetylcholine receptor (AChR) genes. Adenosine Triphosphate 13-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 228-248 16429571-2 2005 The synaptic ATP induces post-synaptic gene transcription during the formation and maintenance of vertebrate neuromuscular junction (nmj) via a mitogen-activaton protein (MAP) kinase signaling pathway and subsequently activates acetylcholinesterase (AChE) and acetylcholine receptor (AChR) genes. Adenosine Triphosphate 13-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 250-254 16429571-6 2005 By using a human AChE promoter tagged with a luciferase-reporter gene, the transcriptional regulation of AChE gene by ATP could be monitored. Adenosine Triphosphate 118-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 16429571-6 2005 By using a human AChE promoter tagged with a luciferase-reporter gene, the transcriptional regulation of AChE gene by ATP could be monitored. Adenosine Triphosphate 118-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 16429574-1 2005 Several studies demonstrated that pretreatment with reversible acetylcholinesterase (AChE) inhibitor, such as (pyridostigmine) PYR, improved the survival of animals intoxicated by organophosphate nerve agents (OP). (pyridostigmine) pyr 110-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 16429574-1 2005 Several studies demonstrated that pretreatment with reversible acetylcholinesterase (AChE) inhibitor, such as (pyridostigmine) PYR, improved the survival of animals intoxicated by organophosphate nerve agents (OP). (pyridostigmine) pyr 110-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 16429574-1 2005 Several studies demonstrated that pretreatment with reversible acetylcholinesterase (AChE) inhibitor, such as (pyridostigmine) PYR, improved the survival of animals intoxicated by organophosphate nerve agents (OP). Organophosphates 180-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 16429574-1 2005 Several studies demonstrated that pretreatment with reversible acetylcholinesterase (AChE) inhibitor, such as (pyridostigmine) PYR, improved the survival of animals intoxicated by organophosphate nerve agents (OP). Organophosphates 180-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 16498728-1 2005 Kinetics of hydrolysis of acetylthiocholine (ATCH) and acetylcholine (ACH) by butyrylcholinesterase (BCHE) and acetylcholinesterase (ACHE) are studied. Acetylthiocholine 26-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 16498728-1 2005 Kinetics of hydrolysis of acetylthiocholine (ATCH) and acetylcholine (ACH) by butyrylcholinesterase (BCHE) and acetylcholinesterase (ACHE) are studied. Acetylthiocholine 26-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 16498728-1 2005 Kinetics of hydrolysis of acetylthiocholine (ATCH) and acetylcholine (ACH) by butyrylcholinesterase (BCHE) and acetylcholinesterase (ACHE) are studied. Acetylthiocholine 45-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 16498728-1 2005 Kinetics of hydrolysis of acetylthiocholine (ATCH) and acetylcholine (ACH) by butyrylcholinesterase (BCHE) and acetylcholinesterase (ACHE) are studied. Acetylthiocholine 45-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 16498728-1 2005 Kinetics of hydrolysis of acetylthiocholine (ATCH) and acetylcholine (ACH) by butyrylcholinesterase (BCHE) and acetylcholinesterase (ACHE) are studied. Acetylcholine 55-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 16498728-1 2005 Kinetics of hydrolysis of acetylthiocholine (ATCH) and acetylcholine (ACH) by butyrylcholinesterase (BCHE) and acetylcholinesterase (ACHE) are studied. Acetylcholine 55-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 16498728-1 2005 Kinetics of hydrolysis of acetylthiocholine (ATCH) and acetylcholine (ACH) by butyrylcholinesterase (BCHE) and acetylcholinesterase (ACHE) are studied. Acetylcholine 70-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 16498728-1 2005 Kinetics of hydrolysis of acetylthiocholine (ATCH) and acetylcholine (ACH) by butyrylcholinesterase (BCHE) and acetylcholinesterase (ACHE) are studied. Acetylcholine 70-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 15904945-2 2005 Standard treatment with atropine and the established acetylcholinesterase (AChE) reactivators, obidoxime and pralidoxime, is considered to be ineffective with certain nerve agents due to low oxime effectiveness. Obidoxime Chloride 95-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 15904945-2 2005 Standard treatment with atropine and the established acetylcholinesterase (AChE) reactivators, obidoxime and pralidoxime, is considered to be ineffective with certain nerve agents due to low oxime effectiveness. Obidoxime Chloride 95-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 15904945-2 2005 Standard treatment with atropine and the established acetylcholinesterase (AChE) reactivators, obidoxime and pralidoxime, is considered to be ineffective with certain nerve agents due to low oxime effectiveness. pralidoxime 109-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 15904945-2 2005 Standard treatment with atropine and the established acetylcholinesterase (AChE) reactivators, obidoxime and pralidoxime, is considered to be ineffective with certain nerve agents due to low oxime effectiveness. pralidoxime 109-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 15904945-2 2005 Standard treatment with atropine and the established acetylcholinesterase (AChE) reactivators, obidoxime and pralidoxime, is considered to be ineffective with certain nerve agents due to low oxime effectiveness. Oximes 99-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 15904945-2 2005 Standard treatment with atropine and the established acetylcholinesterase (AChE) reactivators, obidoxime and pralidoxime, is considered to be ineffective with certain nerve agents due to low oxime effectiveness. Oximes 99-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 15904945-5 2005 Since reactivation of OP-inhibited AChE is considered to be the main mechanism of action of oximes, human erythrocyte AChE can be exploited to test the efficacy of new oximes. Oximes 92-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 17438836-0 2006 Reactivation potency of new group of acetylcholinesterase reactivators and their comparison with currently available oximes. Oximes 117-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 17438836-1 2006 In this work, in vitro potency of novel serie of monoquaternary pyridinium oximes to reactivate cyclosarin-inhibited acetylcholinesterase (AChE) was tested. pyridinium oximes 64-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 17438836-1 2006 In this work, in vitro potency of novel serie of monoquaternary pyridinium oximes to reactivate cyclosarin-inhibited acetylcholinesterase (AChE) was tested. pyridinium oximes 64-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 17438836-1 2006 In this work, in vitro potency of novel serie of monoquaternary pyridinium oximes to reactivate cyclosarin-inhibited acetylcholinesterase (AChE) was tested. cyclohexyl methylphosphonofluoridate 96-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 17438836-1 2006 In this work, in vitro potency of novel serie of monoquaternary pyridinium oximes to reactivate cyclosarin-inhibited acetylcholinesterase (AChE) was tested. cyclohexyl methylphosphonofluoridate 96-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 15923153-1 2006 The effect of polyamidoamine (PAMAM) dendrimers on activity and fluorescence of pure acetylcholinesterase (EC 3.1.1.7.) Poly(amidoamine) 14-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 15923153-1 2006 The effect of polyamidoamine (PAMAM) dendrimers on activity and fluorescence of pure acetylcholinesterase (EC 3.1.1.7.) Poly(amidoamine) 30-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 15923153-5 2006 The data on the intrinsic fluorescence have shown that the dendrimers changed acetylcholinesterase conformation and the strongest effect was induced by PAMAM G3.5 dendrimer. Poly(amidoamine) 152-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 16375580-8 2006 In an in vitro study, incubation of Hcy-activated membrane AChE from controls with phenylalanine resulted in restoration of activity, but failed to reverse the stimulated enzyme from hyperhomocysteinaemic MTHFR C677T subjects before therapy. Homocysteine 36-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 16375580-8 2006 In an in vitro study, incubation of Hcy-activated membrane AChE from controls with phenylalanine resulted in restoration of activity, but failed to reverse the stimulated enzyme from hyperhomocysteinaemic MTHFR C677T subjects before therapy. Phenylalanine 83-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 16375580-10 2006 CONCLUSIONS: Increased membrane AChE activity may be due to high Hcy levels. Homocysteine 65-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 16373816-1 2006 Rivastigmine, which has been approved by the US Food and Drugs Administration for the treatment of Alzheimer"s disease, is a non-competitive reversible inhibitor of acetylcholinesterase. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-185 16193529-10 2006 Red blood cell (RBC) acetylcholinesterase (AChE) activities in whole blood were measured photometrically in the presence of different POX concentrations and the IC50 was calculated. Paraoxon 134-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 16193529-10 2006 Red blood cell (RBC) acetylcholinesterase (AChE) activities in whole blood were measured photometrically in the presence of different POX concentrations and the IC50 was calculated. Paraoxon 134-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 17009246-7 2006 The activity of acetylcholinesterase was significantly reduced in the methanol-exposed animals. Methanol 70-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 17192616-6 2006 Our aim was to find out how the temporal profile of the AChE mRNA decrease is reflected at the level of AChE activity under normal conditions and after inhibition of preexisting AChE by diisopropyl phosphorofluoridate (DFP).AChE activity was determined at selected time intervals after siRNA treatment in both myoblast homogenates and in culture medium to follow the effects of siRNA treatment at the level of intracellular AChE synthesis and at the level of AChE secreted from the cell. Isoflurophate 186-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 17192616-6 2006 Our aim was to find out how the temporal profile of the AChE mRNA decrease is reflected at the level of AChE activity under normal conditions and after inhibition of preexisting AChE by diisopropyl phosphorofluoridate (DFP).AChE activity was determined at selected time intervals after siRNA treatment in both myoblast homogenates and in culture medium to follow the effects of siRNA treatment at the level of intracellular AChE synthesis and at the level of AChE secreted from the cell. Isoflurophate 219-222 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 17192624-1 2006 Apart from the hydrolysis of acetylcholine (ACh), acetyl- (AChE) and butyrylcholinesterase (BChE), through noncatalytic mechanisms, intervene in hematopoiesis, morphogenesis, and neurogenesis (Layer and Willbold, 1995; Soreq and Seidman, 2001). Acetylcholine 29-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 17192653-4 2006 We investigated the interactions of five bispyridinium oximes with human erythrocyte AChE and their effects on tabun- and soman-poisoned mice. bispyridinium oximes 41-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 17192673-4 2006 ColQ characterizes the collagen-tailed forms (Aforms) of AChE and butyrylcholinesterase (BChE), which are localized in the basal lamina at neuromuscular junctions (NMJs) of vertebrates (Krejci et al., 1999); in these molecules (A4, A8, A12), one, two, or three tetramers of catalytic subunits are disulfide-linked to the strands of a triple helix of ColQ collagen. Disulfides 297-306 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 17192673-7 2006 PRiMAcDNA encodes a single-pass approximately 20-kDa type-I transmembrane protein and, similar to that of ColQ, contains a short PRAD (proline-rich attachment domain) that is able to organize AChE catalytic subunits into tetramers and anchor the enzyme at the surface of neuron and muscle (Massoulie, 2002). Proline 135-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 17192676-3 2006 This means that ChE functioning during development fits into the classical cholinergic neurotransmitter system: acetylcholine (ACh), as a signal, binds to ACh receptors and then is degraded by acetylcholinesterase (AChE) as the terminating enzyme. Acetylcholine 112-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-213 17192676-3 2006 This means that ChE functioning during development fits into the classical cholinergic neurotransmitter system: acetylcholine (ACh), as a signal, binds to ACh receptors and then is degraded by acetylcholinesterase (AChE) as the terminating enzyme. Acetylcholine 112-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 215-219 17192676-3 2006 This means that ChE functioning during development fits into the classical cholinergic neurotransmitter system: acetylcholine (ACh), as a signal, binds to ACh receptors and then is degraded by acetylcholinesterase (AChE) as the terminating enzyme. Acetylcholine 127-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-213 16849010-1 2006 Pyridostigmine bromide (PB) is a quartenary ammonium compound that inhibits the hydrolysis of acetylcholine by competitive reversible binding to acetylcholinesterase. Pyridostigmine Bromide 0-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 16849010-1 2006 Pyridostigmine bromide (PB) is a quartenary ammonium compound that inhibits the hydrolysis of acetylcholine by competitive reversible binding to acetylcholinesterase. Pyridostigmine Bromide 24-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 16849010-1 2006 Pyridostigmine bromide (PB) is a quartenary ammonium compound that inhibits the hydrolysis of acetylcholine by competitive reversible binding to acetylcholinesterase. quartenary ammonium 33-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 16849010-1 2006 Pyridostigmine bromide (PB) is a quartenary ammonium compound that inhibits the hydrolysis of acetylcholine by competitive reversible binding to acetylcholinesterase. Acetylcholine 94-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 17125036-0 2006 [Possible consequences of acetylcholinesterase inhibition in organophosphate poisoning. Organophosphates 61-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 17125036-2 2006 Numerous toxicologists still believe that the only function of acetylcholinesterase (AChE) is to catalyse the hydrolysis of acetylcholine (ACh), and that the toxicity of organophosphorous pesticides (OP) results from their ability to switch this function off. Acetylcholine 63-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 17125036-2 2006 Numerous toxicologists still believe that the only function of acetylcholinesterase (AChE) is to catalyse the hydrolysis of acetylcholine (ACh), and that the toxicity of organophosphorous pesticides (OP) results from their ability to switch this function off. Acetylcholine 85-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 17125036-2 2006 Numerous toxicologists still believe that the only function of acetylcholinesterase (AChE) is to catalyse the hydrolysis of acetylcholine (ACh), and that the toxicity of organophosphorous pesticides (OP) results from their ability to switch this function off. organophosphorous 170-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 17125036-4 2006 There is now no doubt that apart from catalysing the ACh hydrolysis, AChE performs also nonenzymatic functions, trophic (e.g., stimulation of neuritogenesis and remodeling) and neuromodulatory (promotion of long-term functional changes in the central nervous system). Acetylcholine 53-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 16298243-3 2006 We hypothesized that cholinergic malfunction may underlie memory impairment in these subjects and applied a low dosage of an acetylcholinesterase inhibitor and modulator of nicotinic acetylcholine receptors, galantamine (4 mg bid), for 7 days. Galantamine 208-219 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 16129618-0 2006 The effect of aspartame metabolites on human erythrocyte membrane acetylcholinesterase activity. Aspartame 14-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 16129618-2 2006 The aim of this study was to evaluate acetylcholinesterase (AChE) activity in human erythrocyte membranes after incubation with the sum of ASP metabolites, phenylalanine (Phe), methanol (met) and aspartic acid (aspt), or with each one separately. Aspartame 139-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 16129618-2 2006 The aim of this study was to evaluate acetylcholinesterase (AChE) activity in human erythrocyte membranes after incubation with the sum of ASP metabolites, phenylalanine (Phe), methanol (met) and aspartic acid (aspt), or with each one separately. Aspartame 139-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 16129618-2 2006 The aim of this study was to evaluate acetylcholinesterase (AChE) activity in human erythrocyte membranes after incubation with the sum of ASP metabolites, phenylalanine (Phe), methanol (met) and aspartic acid (aspt), or with each one separately. Phenylalanine 156-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 16129618-2 2006 The aim of this study was to evaluate acetylcholinesterase (AChE) activity in human erythrocyte membranes after incubation with the sum of ASP metabolites, phenylalanine (Phe), methanol (met) and aspartic acid (aspt), or with each one separately. Phenylalanine 156-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 16129618-2 2006 The aim of this study was to evaluate acetylcholinesterase (AChE) activity in human erythrocyte membranes after incubation with the sum of ASP metabolites, phenylalanine (Phe), methanol (met) and aspartic acid (aspt), or with each one separately. Phenylalanine 171-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 16129618-2 2006 The aim of this study was to evaluate acetylcholinesterase (AChE) activity in human erythrocyte membranes after incubation with the sum of ASP metabolites, phenylalanine (Phe), methanol (met) and aspartic acid (aspt), or with each one separately. Phenylalanine 171-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 16129618-2 2006 The aim of this study was to evaluate acetylcholinesterase (AChE) activity in human erythrocyte membranes after incubation with the sum of ASP metabolites, phenylalanine (Phe), methanol (met) and aspartic acid (aspt), or with each one separately. Methanol 177-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 16129618-2 2006 The aim of this study was to evaluate acetylcholinesterase (AChE) activity in human erythrocyte membranes after incubation with the sum of ASP metabolites, phenylalanine (Phe), methanol (met) and aspartic acid (aspt), or with each one separately. Methanol 177-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 16129618-2 2006 The aim of this study was to evaluate acetylcholinesterase (AChE) activity in human erythrocyte membranes after incubation with the sum of ASP metabolites, phenylalanine (Phe), methanol (met) and aspartic acid (aspt), or with each one separately. Aspartic Acid 196-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 16129618-2 2006 The aim of this study was to evaluate acetylcholinesterase (AChE) activity in human erythrocyte membranes after incubation with the sum of ASP metabolites, phenylalanine (Phe), methanol (met) and aspartic acid (aspt), or with each one separately. Aspartic Acid 196-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 16129618-2 2006 The aim of this study was to evaluate acetylcholinesterase (AChE) activity in human erythrocyte membranes after incubation with the sum of ASP metabolites, phenylalanine (Phe), methanol (met) and aspartic acid (aspt), or with each one separately. Aspartic Acid 211-215 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 16129618-2 2006 The aim of this study was to evaluate acetylcholinesterase (AChE) activity in human erythrocyte membranes after incubation with the sum of ASP metabolites, phenylalanine (Phe), methanol (met) and aspartic acid (aspt), or with each one separately. Aspartic Acid 211-215 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 16129618-6 2006 Aspt concentrations 2.80 mM, 7.60 mM or 10.0 mM inhibited membrane AChE activity by -20%, -35%, and -47%, respectively. ASPT 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 16288482-2 2006 The computational results consistently reveal a unique role of the oxyanion hole (consisting of G116, G117, and A199) in BChE-catalyzed hydrolysis of cocaine, compared to acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylcholine. Cocaine 150-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-197 16381583-3 2006 Lycoperine A (1) exhibited an inhibitory activity against acetylcholinesterase. lycoperine A 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 16854005-1 2005 Molecular dynamics (MD) simulations and hydrogen bonding energy (HBE) calculations have been performed on the prereactive enzyme-substrate complexes (ES), transition states (TS1), and intermediates (INT1) for acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylcholine (ACh), butyrylcholinesterase (BChE)-catalyzed hydrolysis of ACh, and BChE-catalyzed hydrolysis of (+)/(-)-cocaine to examine the protein environmental effects on the catalytic reactions. Hydrogen 40-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-229 16854005-1 2005 Molecular dynamics (MD) simulations and hydrogen bonding energy (HBE) calculations have been performed on the prereactive enzyme-substrate complexes (ES), transition states (TS1), and intermediates (INT1) for acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylcholine (ACh), butyrylcholinesterase (BChE)-catalyzed hydrolysis of ACh, and BChE-catalyzed hydrolysis of (+)/(-)-cocaine to examine the protein environmental effects on the catalytic reactions. Einsteinium 150-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-229 16854005-1 2005 Molecular dynamics (MD) simulations and hydrogen bonding energy (HBE) calculations have been performed on the prereactive enzyme-substrate complexes (ES), transition states (TS1), and intermediates (INT1) for acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylcholine (ACh), butyrylcholinesterase (BChE)-catalyzed hydrolysis of ACh, and BChE-catalyzed hydrolysis of (+)/(-)-cocaine to examine the protein environmental effects on the catalytic reactions. Acetylcholine 209-222 acetylcholinesterase (Cartwright blood group) Homo sapiens 231-235 16854005-1 2005 Molecular dynamics (MD) simulations and hydrogen bonding energy (HBE) calculations have been performed on the prereactive enzyme-substrate complexes (ES), transition states (TS1), and intermediates (INT1) for acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylcholine (ACh), butyrylcholinesterase (BChE)-catalyzed hydrolysis of ACh, and BChE-catalyzed hydrolysis of (+)/(-)-cocaine to examine the protein environmental effects on the catalytic reactions. Acetylcholine 231-234 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-229 16854005-1 2005 Molecular dynamics (MD) simulations and hydrogen bonding energy (HBE) calculations have been performed on the prereactive enzyme-substrate complexes (ES), transition states (TS1), and intermediates (INT1) for acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylcholine (ACh), butyrylcholinesterase (BChE)-catalyzed hydrolysis of ACh, and BChE-catalyzed hydrolysis of (+)/(-)-cocaine to examine the protein environmental effects on the catalytic reactions. Acetylcholine 276-279 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-229 16854005-1 2005 Molecular dynamics (MD) simulations and hydrogen bonding energy (HBE) calculations have been performed on the prereactive enzyme-substrate complexes (ES), transition states (TS1), and intermediates (INT1) for acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylcholine (ACh), butyrylcholinesterase (BChE)-catalyzed hydrolysis of ACh, and BChE-catalyzed hydrolysis of (+)/(-)-cocaine to examine the protein environmental effects on the catalytic reactions. Acetylcholine 276-279 acetylcholinesterase (Cartwright blood group) Homo sapiens 231-235 16854005-2 2005 The hydrogen bonding of cocaine with the oxyanion hole of BChE is found to be remarkably different from that of ACh with AChE/BChE. Acetylcholine 112-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 16854005-3 2005 Whereas G121/G116, G122/G117, and A204/A199 of AChE/BChE all can form hydrogen bonds with ACh to stabilize the transition state during the ACh hydrolysis, BChE only uses G117 and A199 to form hydrogen bonds with cocaine. Hydrogen 70-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 16854005-3 2005 Whereas G121/G116, G122/G117, and A204/A199 of AChE/BChE all can form hydrogen bonds with ACh to stabilize the transition state during the ACh hydrolysis, BChE only uses G117 and A199 to form hydrogen bonds with cocaine. Acetylcholine 90-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 16854005-3 2005 Whereas G121/G116, G122/G117, and A204/A199 of AChE/BChE all can form hydrogen bonds with ACh to stabilize the transition state during the ACh hydrolysis, BChE only uses G117 and A199 to form hydrogen bonds with cocaine. Hydrogen 192-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 16854005-3 2005 Whereas G121/G116, G122/G117, and A204/A199 of AChE/BChE all can form hydrogen bonds with ACh to stabilize the transition state during the ACh hydrolysis, BChE only uses G117 and A199 to form hydrogen bonds with cocaine. Cocaine 212-219 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 16854005-8 2005 These results help to understand why the catalytic activity of AChE against ACh is considerably higher than that of BChE against cocaine and provides valuable clues on how to improve the catalytic activity of BChE against cocaine. Cocaine 129-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 16601783-1 2005 Galantamine (GAL) is a selective, competitive and reversible acetylcholinesterase (AChE) inhibitor, which increases the activity of the cholinergic system and hence gives rise to an improvement of cognitive functions in patients suffering from dementia of Alzheimer type. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 16601783-1 2005 Galantamine (GAL) is a selective, competitive and reversible acetylcholinesterase (AChE) inhibitor, which increases the activity of the cholinergic system and hence gives rise to an improvement of cognitive functions in patients suffering from dementia of Alzheimer type. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 16601783-1 2005 Galantamine (GAL) is a selective, competitive and reversible acetylcholinesterase (AChE) inhibitor, which increases the activity of the cholinergic system and hence gives rise to an improvement of cognitive functions in patients suffering from dementia of Alzheimer type. Galantamine 13-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 16601783-1 2005 Galantamine (GAL) is a selective, competitive and reversible acetylcholinesterase (AChE) inhibitor, which increases the activity of the cholinergic system and hence gives rise to an improvement of cognitive functions in patients suffering from dementia of Alzheimer type. Galantamine 13-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 16601804-1 2005 The mechanism of intoxication with organophosphorus compounds, including highly toxic nerve agents, is based on the formation of irreversibly inhibited acetylcholinesterase (AChE; EC 3.1.1.7) that could be followed by a generalized cholinergic crisis. organophosphorus 35-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 16601804-1 2005 The mechanism of intoxication with organophosphorus compounds, including highly toxic nerve agents, is based on the formation of irreversibly inhibited acetylcholinesterase (AChE; EC 3.1.1.7) that could be followed by a generalized cholinergic crisis. organophosphorus 35-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 16137794-0 2005 Synthesis and biological evaluation as AChE inhibitors of new indanones and thiaindanones related to donepezil. Indans 62-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 16137794-0 2005 Synthesis and biological evaluation as AChE inhibitors of new indanones and thiaindanones related to donepezil. thiaindanones 76-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 16137794-0 2005 Synthesis and biological evaluation as AChE inhibitors of new indanones and thiaindanones related to donepezil. Donepezil 101-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 16137794-1 2005 Sixty-four new indanones and thiaindanones related to donepezil were synthesized and evaluated in vitro as potential AChE inhibitors. Donepezil 54-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 16182411-1 2005 Three series of functionalized coumarin compounds were designed and prepared as cholinesterase (AChE and BuChE) inhibitors. coumarin 31-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 16144975-0 2005 Unequal neuroprotection afforded by the acetylcholinesterase inhibitors galantamine, donepezil, and rivastigmine in SH-SY5Y neuroblastoma cells: role of nicotinic receptors. Galantamine 72-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 15904945-6 2005 By combining enzyme kinetics (inhibition, reactivation, aging) with OP toxicokinetics and oxime pharmacokinetics a dynamic in vitro model was developed which allows the calculation of AChE activities at different scenarios. Oximes 90-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-188 16144975-0 2005 Unequal neuroprotection afforded by the acetylcholinesterase inhibitors galantamine, donepezil, and rivastigmine in SH-SY5Y neuroblastoma cells: role of nicotinic receptors. Rivastigmine 100-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 16144975-1 2005 Donepezil, rivastigmine, and galantamine are three drugs with acetylcholinesterase (AChE)-inhibiting activity that are currently being used to treat patients suffering from Alzheimer"s disease. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 16144975-1 2005 Donepezil, rivastigmine, and galantamine are three drugs with acetylcholinesterase (AChE)-inhibiting activity that are currently being used to treat patients suffering from Alzheimer"s disease. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 16144975-1 2005 Donepezil, rivastigmine, and galantamine are three drugs with acetylcholinesterase (AChE)-inhibiting activity that are currently being used to treat patients suffering from Alzheimer"s disease. Rivastigmine 11-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 16144975-1 2005 Donepezil, rivastigmine, and galantamine are three drugs with acetylcholinesterase (AChE)-inhibiting activity that are currently being used to treat patients suffering from Alzheimer"s disease. Rivastigmine 11-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 16144975-1 2005 Donepezil, rivastigmine, and galantamine are three drugs with acetylcholinesterase (AChE)-inhibiting activity that are currently being used to treat patients suffering from Alzheimer"s disease. Galantamine 29-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 16144975-1 2005 Donepezil, rivastigmine, and galantamine are three drugs with acetylcholinesterase (AChE)-inhibiting activity that are currently being used to treat patients suffering from Alzheimer"s disease. Galantamine 29-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 16183853-4 2005 Previous studies have identified several allosteric muscarinic ligands, including the acetylcholinesterase inhibitor tacrine and the bis-pyridinium derivative 4,4"-bis-[(2,6-dichloro-benzyloxy-imino)-methyl]-1,1"-propane-1,3-diyl-bis-pyridinium dibromide (Duo3), which, in contrast to conventional allosteric muscarinic ligands, display concentration-effect curves with slope factors >1. Tacrine 117-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 16081111-5 2005 Here, we demonstrate that mefloquine inhibits human recombinant acetylcholinesterase. Mefloquine 26-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 16362770-6 2005 Preliminary results of AChE activity in human blood showed 60-97% and 43-89% of pre-exposed level after one and three days of donepezil administration (5 mg daily), respectively. Donepezil 126-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 15920507-0 2005 Estimation of plasma IC50 of donepezil hydrochloride for brain acetylcholinesterase inhibition in monkey using N-[11C]methylpiperidin-4-yl acetate ([11C]MP4A) and PET. Donepezil 29-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 15920507-1 2005 Donepezil hydrochloride is a potent and selective inhibitor for brain acetylcholinesterase (AChE) and is currently used worldwide for the treatment of Alzheimer"s disease. Donepezil 0-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 15920507-1 2005 Donepezil hydrochloride is a potent and selective inhibitor for brain acetylcholinesterase (AChE) and is currently used worldwide for the treatment of Alzheimer"s disease. Donepezil 0-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 15920507-3 2005 The purpose of this study was to estimate in vivo plasma IC(50) of donepezil in living monkeys by measuring plasma donepezil concentration (LC/MS/MS) and brain AChE activity with positron emission tomography (PET) and N-[(11)C]methylpiperidin-4-yl acetate, which is an acetylcholine analog recently developed by us for quantifying in vivo brain AChE activity. Donepezil 67-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 15920507-3 2005 The purpose of this study was to estimate in vivo plasma IC(50) of donepezil in living monkeys by measuring plasma donepezil concentration (LC/MS/MS) and brain AChE activity with positron emission tomography (PET) and N-[(11)C]methylpiperidin-4-yl acetate, which is an acetylcholine analog recently developed by us for quantifying in vivo brain AChE activity. Donepezil 67-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 345-349 15920507-6 2005 The plasma donepezil concentrations 14 min after intravenous injection were proportional to the doses, 17.2+/-2.9 ng/ml (donepezil-1) and 44.0+/-5.0 ng/ml (donepezil-2), and the mean AChE inhibitions in four neocortical regions as evaluated by PET were also dose-dependent, 27% (donepezil-1) and 53% (donepezil-2). Donepezil 11-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-187 16279781-3 2005 More importantly, these dual AChE inhibitors inhibit the AChE-induced A beta peptide aggregation with IC50 values 1 order of magnitude lower than that of propidium, thus being the most potent derivatives with this activity reported up to date. Propidium 154-163 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 16279781-3 2005 More importantly, these dual AChE inhibitors inhibit the AChE-induced A beta peptide aggregation with IC50 values 1 order of magnitude lower than that of propidium, thus being the most potent derivatives with this activity reported up to date. Propidium 154-163 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 16279811-4 2005 The structure of the new highly potent AChE inhibitor, 9-amino-5,6,7,8-tetrahydroacridin-4yl)methanol (1), was elucidated by NMR spectroscopy and ESI (tandem) mass spectrometry. (9-amino-5,6,7,8-tetrahydroacridin-4-yl)methanol 55-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 16274232-6 2005 These compounds are among the most potent inhibitors of amyloid beta-peptide aggregation and are equivalent only to propidium, a well-characterized AChE peripheral anionic site binder and aggregation inhibitor. Propidium 116-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 16274740-1 2005 In this study, a new matrix for immobilization of acetylcholinesterase was investigated by using alginate and kappa-carrageenan. Alginates 97-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 16274740-1 2005 In this study, a new matrix for immobilization of acetylcholinesterase was investigated by using alginate and kappa-carrageenan. Carrageenan 110-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 16024879-3 2005 METHODS: We evaluated whether SAI testing, together with SAI test-retest, after a single dose of the acetylcholinesterase (AChE) inhibitor rivastigmine, might be useful in predicting the response after 1 year treatment with rivastigmine in 16 AD patients. Rivastigmine 139-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 16144975-9 2005 In contrast, the bcl-2 antagonist ethyl[2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylate (HA 14-1) reversed the protective effects of the three AChE inhibitors and that of nicotine. ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate 34-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 16212945-3 2005 The present experiment assessed the ability of rivastigmine, a clinically utilized agent that inhibits acetylcholinesterase and butyrylcholinesterase activities, to inhibit cholinesterases in plaques and tangles. Rivastigmine 47-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 16212945-10 2005 Rivastigmine inhibited acetylcholinesterase in all positive structures in a dose-dependent manner (10(-6)-10(-4) M). Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 16212945-13 2005 In conclusion, rivastigmine is a potent inhibitor of acetylcholinesterase and a more potent inhibitor of butyrylcholinesterase in plaques and tangles. Rivastigmine 15-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 16243090-9 2005 Acetylcholinesterase inhibited by fenthion or dimethoate responded poorly to pralidoxime treatment compared with chlorpyrifos-inhibited acetylcholinesterase. Fenthion 34-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 16243090-9 2005 Acetylcholinesterase inhibited by fenthion or dimethoate responded poorly to pralidoxime treatment compared with chlorpyrifos-inhibited acetylcholinesterase. Dimethoate 46-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 16243090-9 2005 Acetylcholinesterase inhibited by fenthion or dimethoate responded poorly to pralidoxime treatment compared with chlorpyrifos-inhibited acetylcholinesterase. pralidoxime 77-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 16243090-9 2005 Acetylcholinesterase inhibited by fenthion or dimethoate responded poorly to pralidoxime treatment compared with chlorpyrifos-inhibited acetylcholinesterase. Chlorpyrifos 113-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 19595845-0 2005 Reversal of scopolamine-induced deficits with a single dose of donepezil, an acetylcholinesterase inhibitor. Scopolamine 12-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 19595845-0 2005 Reversal of scopolamine-induced deficits with a single dose of donepezil, an acetylcholinesterase inhibitor. Donepezil 63-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 16192761-3 2005 Org 25969 is a modified gamma-cyclodextrin that encapsulates the neuromuscular blocking agent, rocuronium bromide (Esmeron/Zemuron, NV Organon, Oss, The Netherlands), forming a tightly bound complex with an association constant of approximately 10 m. Chemical encapsulation of rocuronium promotes dissociation of rocuronium from the acetylcholine receptor, thereby reversing the neuromuscular block without the side effects associated with acetylcholinesterase inhibitors. gamma-cyclodextrin 24-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 440-460 16248851-8 2005 Subjects receiving 10 mg of phenserine tartrate had a Cmax of 1.95 ng/mL at 1.5 hours, and the mean peak inhibition (Imax) of AChE was 26% (range: 18-34%) at 1.75 hours (tImax) following dosing. Phenserine tartrate 28-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 16248851-10 2005 Evaluation of PK/PD relationships suggested a linear correlation between plasma phenserine concentration and AChE inhibition in the blood. phenserine 80-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 16863459-1 2005 Donepezil is a selective acetylcholinesterase inhibitor that is widely prescribed for Alzheimer"s disease (AD). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 15994894-0 2005 Influence of the water structure on the acetylcholinesterase efficiency. Water 17-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 15994894-1 2005 We have studied the catalytic efficiency of acetylcholinesterase (AChE) in various solutions with ion-disturbed water structure to explore the role that the water structure plays in the substrate-enzyme encounter. Water 112-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 15994894-1 2005 We have studied the catalytic efficiency of acetylcholinesterase (AChE) in various solutions with ion-disturbed water structure to explore the role that the water structure plays in the substrate-enzyme encounter. Water 112-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 15994894-1 2005 We have studied the catalytic efficiency of acetylcholinesterase (AChE) in various solutions with ion-disturbed water structure to explore the role that the water structure plays in the substrate-enzyme encounter. Water 157-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 15994894-1 2005 We have studied the catalytic efficiency of acetylcholinesterase (AChE) in various solutions with ion-disturbed water structure to explore the role that the water structure plays in the substrate-enzyme encounter. Water 157-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 15994894-3 2005 The influence of water structure on the degree of solvation and on the intramolecular mobility of AChE was investigated for different aqueous ionic solutions by small-angle x-ray scattering technique and depolarization fluorescence spectroscopy. Water 17-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 15994894-4 2005 It was found that the encounter process between AChE and acetylthiocholine was promoted in solutions with less structured water. Acetylthiocholine 57-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 15994894-4 2005 It was found that the encounter process between AChE and acetylthiocholine was promoted in solutions with less structured water. Water 122-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 15994894-6 2005 The found experimental results suggest that the water structure may influence the substrate-enzyme encounter process by diminishing the AChE solvation shell and may help diffusion of the substrate through the gorge by enhancing the intramolecular mobility of AChE. Water 48-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 15994894-6 2005 The found experimental results suggest that the water structure may influence the substrate-enzyme encounter process by diminishing the AChE solvation shell and may help diffusion of the substrate through the gorge by enhancing the intramolecular mobility of AChE. Water 48-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 259-263 16108094-1 2005 The withanolides 1-3 and 4-5 isolated from Ajuga bracteosa and Withania somnifera, respectively, inhibited acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BChE, EC 3.1.1.8) enzymes in a concentration-dependent fashion with IC50 values ranging between 20.5 and 49,2 microm and 29.0 and 85.2 microm for AChE and BChE, respectively. Withanolides 4-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 16108094-1 2005 The withanolides 1-3 and 4-5 isolated from Ajuga bracteosa and Withania somnifera, respectively, inhibited acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BChE, EC 3.1.1.8) enzymes in a concentration-dependent fashion with IC50 values ranging between 20.5 and 49,2 microm and 29.0 and 85.2 microm for AChE and BChE, respectively. Withanolides 4-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 320-324 16108094-7 2005 The affinity of ligands with AChE was found to be the cumulative effects of number of hydrophobic contacts and hydrogen bonding. Hydrogen 111-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 16076210-1 2005 Recently, alkylene-linked heterodimers of tacrine (1) and 5-amino-5,6,7,8-tetrahydroquinolinone (2, hupyridone) were shown to exhibit higher acetylcholinesterase (AChE) inhibition than either monomeric 1 or 2. alkylene 10-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 16076210-1 2005 Recently, alkylene-linked heterodimers of tacrine (1) and 5-amino-5,6,7,8-tetrahydroquinolinone (2, hupyridone) were shown to exhibit higher acetylcholinesterase (AChE) inhibition than either monomeric 1 or 2. alkylene 10-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 16076210-1 2005 Recently, alkylene-linked heterodimers of tacrine (1) and 5-amino-5,6,7,8-tetrahydroquinolinone (2, hupyridone) were shown to exhibit higher acetylcholinesterase (AChE) inhibition than either monomeric 1 or 2. Tacrine 42-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 16076210-1 2005 Recently, alkylene-linked heterodimers of tacrine (1) and 5-amino-5,6,7,8-tetrahydroquinolinone (2, hupyridone) were shown to exhibit higher acetylcholinesterase (AChE) inhibition than either monomeric 1 or 2. Tacrine 42-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 16076210-1 2005 Recently, alkylene-linked heterodimers of tacrine (1) and 5-amino-5,6,7,8-tetrahydroquinolinone (2, hupyridone) were shown to exhibit higher acetylcholinesterase (AChE) inhibition than either monomeric 1 or 2. ,7,8-tetrahydroquinolinone 69-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 16076210-1 2005 Recently, alkylene-linked heterodimers of tacrine (1) and 5-amino-5,6,7,8-tetrahydroquinolinone (2, hupyridone) were shown to exhibit higher acetylcholinesterase (AChE) inhibition than either monomeric 1 or 2. ,7,8-tetrahydroquinolinone 69-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 16076210-1 2005 Recently, alkylene-linked heterodimers of tacrine (1) and 5-amino-5,6,7,8-tetrahydroquinolinone (2, hupyridone) were shown to exhibit higher acetylcholinesterase (AChE) inhibition than either monomeric 1 or 2. 5-amino-5,6,7,8-tetrahydroquinolin-2(1H)-one 100-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 16076210-1 2005 Recently, alkylene-linked heterodimers of tacrine (1) and 5-amino-5,6,7,8-tetrahydroquinolinone (2, hupyridone) were shown to exhibit higher acetylcholinesterase (AChE) inhibition than either monomeric 1 or 2. 5-amino-5,6,7,8-tetrahydroquinolin-2(1H)-one 100-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 16050674-5 2005 Specific carbamates of phenols, 10 and 14, have shown impressive inhibitory activities against human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) ex vivo. Carbamates 9-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 16050674-5 2005 Specific carbamates of phenols, 10 and 14, have shown impressive inhibitory activities against human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) ex vivo. Carbamates 9-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 16050674-5 2005 Specific carbamates of phenols, 10 and 14, have shown impressive inhibitory activities against human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) ex vivo. Phenols 23-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 16050674-5 2005 Specific carbamates of phenols, 10 and 14, have shown impressive inhibitory activities against human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) ex vivo. Phenols 23-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 17784549-25 2006 The AchE activity was higher in the group exposed to mercury vapours compared to the controls and the respective values were - 50.22 +/- 14.44 and 36.87 +/- 2.92 IU/gHb. Mercury 53-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 17784549-25 2006 The AchE activity was higher in the group exposed to mercury vapours compared to the controls and the respective values were - 50.22 +/- 14.44 and 36.87 +/- 2.92 IU/gHb. 4-hydroxybutyric acid 165-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 16307702-3 2005 In addition to acetylcholinesterase (AChE) inhibition, rivastigmine also inhibits butrylcholinesterase (BuChE), providing dual AChE and BuChE inhibition. Rivastigmine 55-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 16307702-4 2005 An observational study was performed to determine the response in routine clinical practice to switching AD patients to rivastigmine from a selective AChE inhibitor when that treatment no longer delivered a satisfactory clinical response. Rivastigmine 120-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 16307702-16 2005 CONCLUSIONS: AD patients deteriorating on selective AChE inhibitor treatment can benefit from switching to a dual AChE-BuChE inhibitor, such as rivastigmine, in terms of stabilization of disease, improvement in cognitive function and reduction in the burden of concomitant psychoactive treatment. Rivastigmine 144-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 16307702-16 2005 CONCLUSIONS: AD patients deteriorating on selective AChE inhibitor treatment can benefit from switching to a dual AChE-BuChE inhibitor, such as rivastigmine, in terms of stabilization of disease, improvement in cognitive function and reduction in the burden of concomitant psychoactive treatment. Rivastigmine 144-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 16485632-0 2005 Potassium channel modulation by acetylcholinesterase inhibitor donepezil. Donepezil 63-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 16262697-1 2005 Acetylcholinesterase is an enzyme whose best-known function is to hydrolyze the neurotransmitter acetylcholine. Acetylcholine 97-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 16149071-0 2005 Histone acetylase inhibitor trichostatin A induces acetylcholinesterase expression and protects against organophosphate exposure. trichostatin A 28-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 16149071-1 2005 The biological effects of organophosphorous (OP) chemical warfare nerve agents (CWNAs) are exerted by inhibition of acetylcholinesterase (AChE), which prevents the hydrolysis of the neurotransmitter acetylcholine, leading to hypercholinergy, seizures/status epilepticus, respiratory/cardiovascular failure, and potentially death. organophosphorous 26-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 16149071-1 2005 The biological effects of organophosphorous (OP) chemical warfare nerve agents (CWNAs) are exerted by inhibition of acetylcholinesterase (AChE), which prevents the hydrolysis of the neurotransmitter acetylcholine, leading to hypercholinergy, seizures/status epilepticus, respiratory/cardiovascular failure, and potentially death. organophosphorous 26-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 16149071-1 2005 The biological effects of organophosphorous (OP) chemical warfare nerve agents (CWNAs) are exerted by inhibition of acetylcholinesterase (AChE), which prevents the hydrolysis of the neurotransmitter acetylcholine, leading to hypercholinergy, seizures/status epilepticus, respiratory/cardiovascular failure, and potentially death. Acetylcholine 116-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 16149071-5 2005 Trichostatin A (TSA), an inhibitor of histone deacetylase that de-condenses the chromatin, thereby increasing the binding of transcription factors and mRNA synthesis, was evaluated for induction of AChE expression in various neuronal cell lines. trichostatin A 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-202 16149071-5 2005 Trichostatin A (TSA), an inhibitor of histone deacetylase that de-condenses the chromatin, thereby increasing the binding of transcription factors and mRNA synthesis, was evaluated for induction of AChE expression in various neuronal cell lines. trichostatin A 16-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-202 16149071-6 2005 Dose-response curves showed that a concentration of 333 nM TSA was optimal in inducing AChE expression. trichostatin A 59-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 16149071-8 2005 Correlating with the AChE induction, TSA pre-treatment significantly protected the cells against exposure to the organophosphate diisopropylfluorophosphate, a surrogate for the chemical warfare agents soman and sarin. trichostatin A 37-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 16149071-9 2005 These studies indicate that transcriptional inducers such as TSA up-regulate AChE, which then can bioscavenge any organophosphates present, thereby protecting the cells from OP-induced cytotoxicity. Organophosphates 114-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 16167316-0 2005 Effect of metoclopramide and ranitidine on the inhibition of human AChE by VX in vitro. Metoclopramide 10-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 16167316-0 2005 Effect of metoclopramide and ranitidine on the inhibition of human AChE by VX in vitro. Ranitidine 29-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 16167316-2 2005 The standard treatment with atropine and acetylcholinesterase (AChE) reactivators ("oximes") is considered to be ineffective with certain nerve agents due to low oxime efficacy. Oximes 84-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 16167316-2 2005 The standard treatment with atropine and acetylcholinesterase (AChE) reactivators ("oximes") is considered to be ineffective with certain nerve agents due to low oxime efficacy. Oximes 84-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 16167316-2 2005 The standard treatment with atropine and acetylcholinesterase (AChE) reactivators ("oximes") is considered to be ineffective with certain nerve agents due to low oxime efficacy. Oximes 84-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 16167316-2 2005 The standard treatment with atropine and acetylcholinesterase (AChE) reactivators ("oximes") is considered to be ineffective with certain nerve agents due to low oxime efficacy. Oximes 84-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 16167316-4 2005 Recently, the clinically used reversible AChE inhibitors metoclopramide (MCP) and ranitidine (RAN) were shown to exhibit some protective effect against the OP pesticide paraoxon in vitro and in vivo. Metoclopramide 57-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 16167316-4 2005 Recently, the clinically used reversible AChE inhibitors metoclopramide (MCP) and ranitidine (RAN) were shown to exhibit some protective effect against the OP pesticide paraoxon in vitro and in vivo. Ranitidine 82-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 16167316-4 2005 Recently, the clinically used reversible AChE inhibitors metoclopramide (MCP) and ranitidine (RAN) were shown to exhibit some protective effect against the OP pesticide paraoxon in vitro and in vivo. Paraoxon 169-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 16167316-5 2005 The present study was undertaken to investigate a potential protective effect of MCP and RAN against inhibition of human AChE by the nerve agent VX (O-ethyl S-[2-(diisopropylamino)ethyl)methylphosphonothioate). VX 149-208 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 16167316-9 2005 At concentrations higher than 100 microm MCP and RAN caused a concentration dependent increase of residual AChE activity 15 min after addition of VX. Metoclopramide 41-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 16335048-2 2005 Their potency to reactivate AChE inhibited by insecticide chlorpyrifos was tested in vitro. Chlorpyrifos 58-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 16335048-3 2005 2,2"-Bis(hydroxyiminomethyl)-1,1"-(1,4-phenylenedimethyl)-bispyridinium dibromide seems to be the most potent AChE reactivator. 2,2"-bis(hydroxyiminomethyl)-1,1"-(1,4-phenylenedimethyl)-bispyridinium dibromide 0-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 16076434-2 2005 Acetylcholinesterase was immobilized on silica gel by covalent binding. Silica Gel 40-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 16076434-4 2005 Carbamate pesticides inhibited acetylcholinesterase and the decrease in the enzyme activity was used to determine these pesticides. Carbamates 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 18970206-1 2005 This is the first study using ionic liquids (ILs) as additive in the aqueous solvent medium for detection of paraoxon by acetylcholinesterase inhibition method. ionic 30-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 16243721-1 2005 Implementation of assay conditions for the use of AChE activity as a biomarker of metal toxicity. Metals 82-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 16243721-4 2005 Therefore, the main purpose of this study was to investigate the potential of five metal ions (nickel, copper, zinc, cadmium and mercury) to inhibit AChE activity in vitro. Metals 83-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 16243721-4 2005 Therefore, the main purpose of this study was to investigate the potential of five metal ions (nickel, copper, zinc, cadmium and mercury) to inhibit AChE activity in vitro. Nickel 95-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 16243721-4 2005 Therefore, the main purpose of this study was to investigate the potential of five metal ions (nickel, copper, zinc, cadmium and mercury) to inhibit AChE activity in vitro. Copper 103-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 16243721-4 2005 Therefore, the main purpose of this study was to investigate the potential of five metal ions (nickel, copper, zinc, cadmium and mercury) to inhibit AChE activity in vitro. Cadmium 117-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 16243721-4 2005 Therefore, the main purpose of this study was to investigate the potential of five metal ions (nickel, copper, zinc, cadmium and mercury) to inhibit AChE activity in vitro. Mercury 129-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 16243721-11 2005 Attending to this evidence, an assay using the substrate o-nitrophenyl acetate and Tris buffer was used to investigate the effects of metals on AChE activity. 2-NITROPHENYL ACETATE 57-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 16243721-11 2005 Attending to this evidence, an assay using the substrate o-nitrophenyl acetate and Tris buffer was used to investigate the effects of metals on AChE activity. Tromethamine 83-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 16243721-14 2005 Under these conditions, the results indicate that with the exception of nickel, all tested metals significantly inhibit AChE activity. Nickel 72-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 16243722-6 2005 The study confirms that placental acetylcholinesterase and catalase activities are significantly associated with periods of organophosphorus pesticides application, while glutathione S-transferase is not affected. organophosphorus 124-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 16245689-3 2005 Theoretical conformational analysis confirms that the completely extended tt conformation of ACh is productive for the hydrolysis by AChE, which agrees with the results of X-ray analysis of AChE. Acetylcholine 93-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 16245689-3 2005 Theoretical conformational analysis confirms that the completely extended tt conformation of ACh is productive for the hydrolysis by AChE, which agrees with the results of X-ray analysis of AChE. Acetylcholine 93-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 190-194 16245689-4 2005 AChE is shown to hydrolyze only those substrates that form equilibrium conformers compatible in the mutual arrangement of trimethylammonium group, carbonyl carbon, and carbonyl oxygen with the tt conformation of ACh; in this case, the rate of substrate hydrolysis depends on the total population of these conformers. Cetrimonium 122-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 16245689-4 2005 AChE is shown to hydrolyze only those substrates that form equilibrium conformers compatible in the mutual arrangement of trimethylammonium group, carbonyl carbon, and carbonyl oxygen with the tt conformation of ACh; in this case, the rate of substrate hydrolysis depends on the total population of these conformers. Carbon 147-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 16245689-4 2005 AChE is shown to hydrolyze only those substrates that form equilibrium conformers compatible in the mutual arrangement of trimethylammonium group, carbonyl carbon, and carbonyl oxygen with the tt conformation of ACh; in this case, the rate of substrate hydrolysis depends on the total population of these conformers. Oxygen 177-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 16102564-8 2005 Acetylcholinesterase was inhibited only by the highest concentrations of CPF (> or =1 microM) and CPFO (> or =1 nM); TCP had no effect on this parameter. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 101-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 15951032-1 2005 Clinical trials show beneficial effects of acetylcholinesterase (AChE) inhibitors, including galantamine, on cognitive functions in patients with mild to moderate Alzheimer"s disease. Galantamine 93-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 16024879-3 2005 METHODS: We evaluated whether SAI testing, together with SAI test-retest, after a single dose of the acetylcholinesterase (AChE) inhibitor rivastigmine, might be useful in predicting the response after 1 year treatment with rivastigmine in 16 AD patients. Rivastigmine 139-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 16021692-0 2005 Juliflorine: a potent natural peripheral anionic-site-binding inhibitor of acetylcholinesterase with calcium-channel blocking potential, a leading candidate for Alzheimer"s disease therapy. juliflorine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 16021692-0 2005 Juliflorine: a potent natural peripheral anionic-site-binding inhibitor of acetylcholinesterase with calcium-channel blocking potential, a leading candidate for Alzheimer"s disease therapy. Calcium 101-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 16021692-1 2005 The alkaloid juliflorine (1) from Prosopis juliflora inhibited acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BChE, EC 3.1.1.8) enzymes in a concentration-dependent fashion with IC50 values 0.42 and 0.12 microM, respectively. juliflorine 13-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 15925113-1 2005 Twelve 1-N-substituted thiocarbamoyl-3-phenyl-5-thienyl-2-pyrazoline derivatives were synthesized and their biological interactions with human plasma and erythrocyte acetylcholinesterase (AChE) and butrylcholinesterase (BuChE) enzymes were assessed. 1-n-substituted thiocarbamoyl-3-phenyl-5-thienyl-2-pyrazoline 7-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-186 15925113-1 2005 Twelve 1-N-substituted thiocarbamoyl-3-phenyl-5-thienyl-2-pyrazoline derivatives were synthesized and their biological interactions with human plasma and erythrocyte acetylcholinesterase (AChE) and butrylcholinesterase (BuChE) enzymes were assessed. 1-n-substituted thiocarbamoyl-3-phenyl-5-thienyl-2-pyrazoline 7-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-192 15925113-2 2005 Compounds 3i-3l of newly synthesized N-substituted pyrazolines, which were presented as selective and irreversible MAO-B inhibitors in our previous report, were found to inhibit human erythrocyte and plasma AChE activities selectively and non-competitively suggesting that these compounds may interact with a region close to the peripheral site of the enzyme molecule which could shift the proper positioning of the catalytic center. n-substituted pyrazolines 37-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-211 15925113-3 2005 Compounds 3e-3h inhibited both AChE and BuChE activities of human erythrocytes, but the inhibitory potencies of these compounds towards BuChE were found to be higher than that of towards AChE. 3e-3h 10-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 15925113-3 2005 Compounds 3e-3h inhibited both AChE and BuChE activities of human erythrocytes, but the inhibitory potencies of these compounds towards BuChE were found to be higher than that of towards AChE. 3e-3h 10-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 15987132-7 2005 To determine the trace level of the recovered antibody-enzyme conjugate, the AChE activity was determined with high sensitivity on the basis of the chemisorption/electrochemical desorption process of thiocholine, which was produced through the enzymatic reaction, on a silver surface. Thiocholine 200-211 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 15987132-8 2005 The thiocholine chemisorption (i.e., accumulation) on the silver electrode surface resulted in a sensitivity for the electrochemical determination of the AChE activity that was 2 orders of magnitude greater than that obtained when using direct measurement without accumulation. Thiocholine 4-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-158 16022504-7 2005 This result confirmed formation of 3-pronged hydrogen bonds for the oxyanion hole of butyrylcholinesterase and 2-pronged hydrogen bonds for the oxyanion hole of acetylcholinesterase. Hydrogen 45-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-181 16022504-7 2005 This result confirmed formation of 3-pronged hydrogen bonds for the oxyanion hole of butyrylcholinesterase and 2-pronged hydrogen bonds for the oxyanion hole of acetylcholinesterase. Hydrogen 121-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-181 16022504-9 2005 Conformations of enzyme-inhibitor tetrahedral intermediates for butyrylcholinesterase were different from those for acetylcholinesterase and cholesterol esterase; ortho substituents in the tetrahedral intermediates were located far from the negatively charged carbonyl oxygens in butyrylcholinesterase, but close to the negatively charged carbonyl oxygens in acetylcholinesterase and cholesterol esterase. Oxygen 269-276 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 16022504-9 2005 Conformations of enzyme-inhibitor tetrahedral intermediates for butyrylcholinesterase were different from those for acetylcholinesterase and cholesterol esterase; ortho substituents in the tetrahedral intermediates were located far from the negatively charged carbonyl oxygens in butyrylcholinesterase, but close to the negatively charged carbonyl oxygens in acetylcholinesterase and cholesterol esterase. Oxygen 348-355 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 16124202-3 2005 AChE reactivators (pralidoxime, obidoxime and HI-6) as causal antidotes are used for the cleavage of the bond between the enzyme and nerve agent. pralidoxime 19-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 16124202-3 2005 AChE reactivators (pralidoxime, obidoxime and HI-6) as causal antidotes are used for the cleavage of the bond between the enzyme and nerve agent. Obidoxime Chloride 32-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 16124202-3 2005 AChE reactivators (pralidoxime, obidoxime and HI-6) as causal antidotes are used for the cleavage of the bond between the enzyme and nerve agent. asoxime chloride 46-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 16124202-10 2005 At a lower concentration of 10(-4) M (the probably attainable concentration in vivo), four AChE reactivators (trimedoxime, obidoxime, K027, and K048) were able to reactivate AChE inhibited by tabun reaching from 10 to 18%. Trimedoxime 110-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 16124202-10 2005 At a lower concentration of 10(-4) M (the probably attainable concentration in vivo), four AChE reactivators (trimedoxime, obidoxime, K027, and K048) were able to reactivate AChE inhibited by tabun reaching from 10 to 18%. Trimedoxime 110-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 16124202-10 2005 At a lower concentration of 10(-4) M (the probably attainable concentration in vivo), four AChE reactivators (trimedoxime, obidoxime, K027, and K048) were able to reactivate AChE inhibited by tabun reaching from 10 to 18%. Obidoxime Chloride 123-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 16124202-10 2005 At a lower concentration of 10(-4) M (the probably attainable concentration in vivo), four AChE reactivators (trimedoxime, obidoxime, K027, and K048) were able to reactivate AChE inhibited by tabun reaching from 10 to 18%. Obidoxime Chloride 123-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 15974895-0 2005 Acetylcholinesterase-amyloid-beta-peptide interaction: effect of Congo Red and the role of the Wnt pathway. Congo Red 65-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 16023967-3 2005 In this work liposome-based biosensors are prepared by encapsulating the enzyme acetylcholinesterase (AChE) in L-a phosphatidylcholine liposomes resulting in spherical optical biosensors with an average diameter of 300+/-4 nm. l-a phosphatidylcholine 111-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 16023967-3 2005 In this work liposome-based biosensors are prepared by encapsulating the enzyme acetylcholinesterase (AChE) in L-a phosphatidylcholine liposomes resulting in spherical optical biosensors with an average diameter of 300+/-4 nm. l-a phosphatidylcholine 111-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 15974895-4 2005 Recently, novel dual inhibitors of AChE have been developed that target both the active site of the enzyme as well as the peripheral anionic site (PAS). Aminosalicylic Acid 147-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 15974895-7 2005 Congo Red dye stabilizes the Abeta monomer, is able to inhibit oligomerization, and inhibits the binding of AChE to Abeta. Congo Red 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 15974895-10 2005 Docking studies were performed to evaluate the binding of Congo Red to Abeta in order to identify putative binding sites in the Abeta monomer that might interact with AChE. Congo Red 58-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 15991031-2 2005 This study applied focal transcranial magnetic stimulation (TMS) to eight healthy subjects to test the effects of a single oral dose of 40 mg tacrine, an acetylcholinesterase inhibitor, on motor cortical excitability. Tacrine 142-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-174 16182707-16 2005 CU causes an alteration of RBC cellular membrane as demonstrated by depletion of AChE. Copper 0-2 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 15974596-0 2005 Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation. xanthostigmine 27-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 15974596-8 2005 The key feature of these derivatives is a 2-arylidenebenzocycloalkanone moiety that provides the ability to bind at the AChE peripheral site responsible for promoting the Abeta aggregation. 2-arylidenebenzocycloalkanone 42-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 15974596-9 2005 The new carbamates were tested in vitro for the inhibition of both cholinesterases and also for the ability to prevent the AChE-induced Abeta aggregation. Carbamates 8-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 15969593-1 2005 We study the ligand (tetramethylammonium) recognition by the peripheral anionic site and its penetration of the human AChE gorge by using atomistic molecular dynamics simulations and our recently developed metadynamics method. tetramethylammonium 21-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 15803498-2 2005 Physostigmine, a potent AChE inhibitor, and galantamine, an allosteric modulator of nAChRs, are widely used for the treatment of Alzheimer"s disease. Physostigmine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 15803498-12 2005 The effects of physostigmine, a more potent AChE inhibitor than galantamine, could be interpreted as a desensitization of nAChRs, due to a prolonged exposure to high synaptic concentration of acetylcholine or as a competition with acetylcholine. Physostigmine 15-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 15893738-1 2005 Donepezil, a potent acetylcholinesterase (AChE) inhibitor used for the treatment of Alzheimer"s disease (AD), is thought to have a neuroprotective effect in AD patients. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 20641912-17 2004 The probe for acetylcholinesterase (N-[(11)C]methylpiperdin-4-yl propionate, [(11)C]PMP) has been used in AD patients and found to show a decrease that is more uniform and broadly distributed than the focal defects found with [(18)F]FDG (12). n-[(11)c]methylpiperdin-4-yl propionate 36-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 20641912-17 2004 The probe for acetylcholinesterase (N-[(11)C]methylpiperdin-4-yl propionate, [(11)C]PMP) has been used in AD patients and found to show a decrease that is more uniform and broadly distributed than the focal defects found with [(18)F]FDG (12). [(11)c]pmp 77-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 15911280-0 2005 Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents. bis-pyridinium oxime 28-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 15911280-2 2005 In the test of their potency to reactivate AChE inhibited by cyclosarin, the bis-pyridinium oxime 6b achieved reactivation potency higher than 10% at the lower concentration 10(-4)M. cyclohexyl methylphosphonofluoridate 61-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 15911280-2 2005 In the test of their potency to reactivate AChE inhibited by cyclosarin, the bis-pyridinium oxime 6b achieved reactivation potency higher than 10% at the lower concentration 10(-4)M. bis-pyridinium oxime 6b 77-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 15907917-1 2005 The synaptic enzyme acetylcholinesterase (AChE) terminates transmission at cholinergic synapses by rapidly hydrolysing acetylcholine. Acetylcholine 20-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 15935907-0 2005 p-Aminobenzoic acid derivatives as acetylcholinesterase inhibitors. 4-Aminobenzoic Acid 0-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 15935907-1 2005 Because Alzheimer"s disease (AD) is a medical problem characterized by progressive loss of memory and cognition that is associated with a deficient cholinergic system, this work aims to evaluate some p-aminobenzoic acid (PABA) derivatives as acetylcholinesterase inhibitors in vitro, in continuation with our last studies. 4-Aminobenzoic Acid 200-219 acetylcholinesterase (Cartwright blood group) Homo sapiens 242-262 15935907-1 2005 Because Alzheimer"s disease (AD) is a medical problem characterized by progressive loss of memory and cognition that is associated with a deficient cholinergic system, this work aims to evaluate some p-aminobenzoic acid (PABA) derivatives as acetylcholinesterase inhibitors in vitro, in continuation with our last studies. 4-Aminobenzoic Acid 221-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 242-262 15772291-4 2005 Previous studies have indicated that CPT-11 can inhibit acetylcholinesterase (AChE), and here, we provide a detailed analysis of the inhibition of AChE by CPT-11 and by structural analogs. Irinotecan 37-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 16119192-3 2005 Therefore, to better evaluate the efficacy of various oximes (pralidoxime, obidoxime, HI-6, K033) to reactivate brain acetylcholinesterase inhibited by sarin by in vitro methods, human, rat and pig brain acetylcholinesterase were used to calculate kinetic parameters for the reactivation. Oximes 54-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 16119192-3 2005 Therefore, to better evaluate the efficacy of various oximes (pralidoxime, obidoxime, HI-6, K033) to reactivate brain acetylcholinesterase inhibited by sarin by in vitro methods, human, rat and pig brain acetylcholinesterase were used to calculate kinetic parameters for the reactivation. pralidoxime 62-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 16119192-3 2005 Therefore, to better evaluate the efficacy of various oximes (pralidoxime, obidoxime, HI-6, K033) to reactivate brain acetylcholinesterase inhibited by sarin by in vitro methods, human, rat and pig brain acetylcholinesterase were used to calculate kinetic parameters for the reactivation. Obidoxime Chloride 75-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 16119192-3 2005 Therefore, to better evaluate the efficacy of various oximes (pralidoxime, obidoxime, HI-6, K033) to reactivate brain acetylcholinesterase inhibited by sarin by in vitro methods, human, rat and pig brain acetylcholinesterase were used to calculate kinetic parameters for the reactivation. asoxime chloride 86-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 16119193-1 2005 Reactivators of acetylcholinesterase (AChE; EC 3.1.1.7) are able to treat intoxication by organophosphorus compounds, especially with pesticides or nerve agents. Organophosphorus Compounds 90-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 16119193-1 2005 Reactivators of acetylcholinesterase (AChE; EC 3.1.1.7) are able to treat intoxication by organophosphorus compounds, especially with pesticides or nerve agents. Organophosphorus Compounds 90-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 16119193-2 2005 Owing to the fact that there exists no universal "broad-spectrum" reactivator of organophosphates-inhibited AChE, many laboratories have synthesized new AChE reactivators. Organophosphates 81-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 16119193-3 2005 Here, we synthesized five new and three previously known quaternary monopyridinium oximes as potential reactivators of AChE inhibited by nerve agents. quaternary monopyridinium oximes 57-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 16119193-5 2005 Their cleaving potencies were compared with 4-PAM (4-hydroxyiminomethyl-1-methylpyridinium iodide), which is derived from the structure of the currently used AChE-reactivator 2-PAM (2-hydroxyiminomethyl-1-methylpyridinium iodide). 4-PAM 44-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 16119193-5 2005 Their cleaving potencies were compared with 4-PAM (4-hydroxyiminomethyl-1-methylpyridinium iodide), which is derived from the structure of the currently used AChE-reactivator 2-PAM (2-hydroxyiminomethyl-1-methylpyridinium iodide). 4-hydroxyiminomethyl-1-methylpyridinium iodide 51-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 16119193-5 2005 Their cleaving potencies were compared with 4-PAM (4-hydroxyiminomethyl-1-methylpyridinium iodide), which is derived from the structure of the currently used AChE-reactivator 2-PAM (2-hydroxyiminomethyl-1-methylpyridinium iodide). pralidoxime 175-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 16119193-6 2005 Three newly synthesized oximes achieved similar nucleophilicity at the similar pKa according to 4-PAM, which is very promising for using these derivatives as AChE reactivators. Oximes 24-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 16119193-6 2005 Three newly synthesized oximes achieved similar nucleophilicity at the similar pKa according to 4-PAM, which is very promising for using these derivatives as AChE reactivators. 4-PAM 96-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 15772291-4 2005 Previous studies have indicated that CPT-11 can inhibit acetylcholinesterase (AChE), and here, we provide a detailed analysis of the inhibition of AChE by CPT-11 and by structural analogs. Irinotecan 37-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 15772291-4 2005 Previous studies have indicated that CPT-11 can inhibit acetylcholinesterase (AChE), and here, we provide a detailed analysis of the inhibition of AChE by CPT-11 and by structural analogs. Irinotecan 155-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 15772291-5 2005 These studies demonstrate that the terminal dipiperidino moiety in CPT-11 plays a major role in enzyme inhibition, and this has been confirmed by X-ray crystallographic studies of a complex of the drug with Torpedo californica AChE. dipiperidino 44-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 227-231 15772291-5 2005 These studies demonstrate that the terminal dipiperidino moiety in CPT-11 plays a major role in enzyme inhibition, and this has been confirmed by X-ray crystallographic studies of a complex of the drug with Torpedo californica AChE. Irinotecan 67-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 227-231 15772291-7 2005 The 3D structure of the CPT-11/AChE complex also permits modeling of CPT-11 complexed with mammalian butyrylcholinesterase and carboxylesterase, both of which are known to hydrolyze the drug to the active metabolite. Irinotecan 24-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 15772291-7 2005 The 3D structure of the CPT-11/AChE complex also permits modeling of CPT-11 complexed with mammalian butyrylcholinesterase and carboxylesterase, both of which are known to hydrolyze the drug to the active metabolite. Irinotecan 69-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 15772291-8 2005 Overall, the results presented here clarify the mechanism of AChE inhibition by CPT-11 and detail the interaction of the drug with the protein. Irinotecan 80-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 15772291-9 2005 These studies may allow the design of both novel camptothecin analogs that would not inhibit AChE and new AChE inhibitors derived from the camptothecin scaffold. Camptothecin 139-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 15870934-5 2005 Treatment with VPA resulted in a strong inhibition of cell proliferation and induction of cell differentiation, as revealed by neurite outgrowth and increase of acetylcholinesterase specific activity. Valproic Acid 15-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-181 15869290-1 2005 The target-guided, in situ click chemistry approach to lead discovery has been successfully employed for discovering acetylcholinesterase (AChE) inhibitors by incubating a selected enzyme/tacrine azide combination with a variety of acetylene reagents that were not previously known to interact with the enzyme"s peripheral binding site. tacrine azide 188-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 15854764-1 2005 We recently reported findings of modest loss of cortical acetylcholinesterase (AChE) activity in patients with overall mild Alzheimer"s disease (AD) using N-[11C]methyl-pi-peridin-4-yl propionate ([11C]PMP) AChE positron emission tomography (PET). n-[11c]methyl-pi-peridin-4-yl propionate 155-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 15854764-1 2005 We recently reported findings of modest loss of cortical acetylcholinesterase (AChE) activity in patients with overall mild Alzheimer"s disease (AD) using N-[11C]methyl-pi-peridin-4-yl propionate ([11C]PMP) AChE positron emission tomography (PET). n-[11c]methyl-pi-peridin-4-yl propionate 155-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 15854764-1 2005 We recently reported findings of modest loss of cortical acetylcholinesterase (AChE) activity in patients with overall mild Alzheimer"s disease (AD) using N-[11C]methyl-pi-peridin-4-yl propionate ([11C]PMP) AChE positron emission tomography (PET). n-[11c]methyl-pi-peridin-4-yl propionate 155-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-211 15854764-1 2005 We recently reported findings of modest loss of cortical acetylcholinesterase (AChE) activity in patients with overall mild Alzheimer"s disease (AD) using N-[11C]methyl-pi-peridin-4-yl propionate ([11C]PMP) AChE positron emission tomography (PET). UNII-S4X91EGA07 197-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 15854764-1 2005 We recently reported findings of modest loss of cortical acetylcholinesterase (AChE) activity in patients with overall mild Alzheimer"s disease (AD) using N-[11C]methyl-pi-peridin-4-yl propionate ([11C]PMP) AChE positron emission tomography (PET). UNII-S4X91EGA07 197-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 15869290-1 2005 The target-guided, in situ click chemistry approach to lead discovery has been successfully employed for discovering acetylcholinesterase (AChE) inhibitors by incubating a selected enzyme/tacrine azide combination with a variety of acetylene reagents that were not previously known to interact with the enzyme"s peripheral binding site. tacrine azide 188-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 15869290-1 2005 The target-guided, in situ click chemistry approach to lead discovery has been successfully employed for discovering acetylcholinesterase (AChE) inhibitors by incubating a selected enzyme/tacrine azide combination with a variety of acetylene reagents that were not previously known to interact with the enzyme"s peripheral binding site. Acetylene 232-241 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 15869290-1 2005 The target-guided, in situ click chemistry approach to lead discovery has been successfully employed for discovering acetylcholinesterase (AChE) inhibitors by incubating a selected enzyme/tacrine azide combination with a variety of acetylene reagents that were not previously known to interact with the enzyme"s peripheral binding site. Acetylene 232-241 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 15869290-5 2005 These new inhibitors are up to 3 times as potent as our previous phenylphenanthridinium-derived compounds, and with dissociation constants as low as 33 femtomolar, they are the most potent noncovalent AChE inhibitors known. phenylphenanthridinium 65-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 201-205 15820219-0 2005 Inhibition of erythrocyte acetylcholinesterase by n-butanol at high concentrations. 1-Butanol 50-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 15951267-6 2005 In routine the measurement of acetylcholinesterase activity is more useful for the biological follow-up of subjects exposed to organophosphate phytosanitary compounds. Organophosphates 127-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 15820219-1 2005 Erythrocyte acetylcholinesterase (AChE) is bound to the membrane by a complex glycosylphosphatidylinositol anchor, so the effect of alcohol on AChE activity may reflect direct and/or membrane-mediated effects. Alcohols 132-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 15820219-1 2005 Erythrocyte acetylcholinesterase (AChE) is bound to the membrane by a complex glycosylphosphatidylinositol anchor, so the effect of alcohol on AChE activity may reflect direct and/or membrane-mediated effects. Alcohols 132-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 15820219-1 2005 Erythrocyte acetylcholinesterase (AChE) is bound to the membrane by a complex glycosylphosphatidylinositol anchor, so the effect of alcohol on AChE activity may reflect direct and/or membrane-mediated effects. Alcohols 132-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 15820219-2 2005 The indication of a direct interaction between n-butanol and AChE molecules is the activation/inhibition of AChE by occupation of the enzyme"s active and/or regulatory sites by alcohol. 1-Butanol 47-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 15820219-2 2005 The indication of a direct interaction between n-butanol and AChE molecules is the activation/inhibition of AChE by occupation of the enzyme"s active and/or regulatory sites by alcohol. 1-Butanol 47-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 15820219-2 2005 The indication of a direct interaction between n-butanol and AChE molecules is the activation/inhibition of AChE by occupation of the enzyme"s active and/or regulatory sites by alcohol. Alcohols 177-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 15820219-2 2005 The indication of a direct interaction between n-butanol and AChE molecules is the activation/inhibition of AChE by occupation of the enzyme"s active and/or regulatory sites by alcohol. Alcohols 177-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 15820219-3 2005 The activation of AChE can occur only at low concentrations of alcohols, while at high concentrations AChE is inhibited. Alcohols 63-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 15820219-4 2005 In this work the mechanism of inhibition of erythrocyte AChE by n-butanol at high concentrations was studied. 1-Butanol 64-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 15820219-6 2005 From the values of the inhibition constants it was concluded that at high n-butanol concentrations two alcohol molecules usually interact with AChE. 1-Butanol 74-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 15820219-6 2005 From the values of the inhibition constants it was concluded that at high n-butanol concentrations two alcohol molecules usually interact with AChE. Alcohols 103-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 21783509-5 2005 Under normal conditions, however, extensive inhibition of AChE leads to excess synaptic acetylcholine levels, over-stimulation of cholinergic receptors, alteration of postsynaptic cell function and consequent signs of cholinergic toxicity. Acetylcholine 88-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 15739192-1 2005 Acylation of acetylcholine (ACh) catalyzed by acetylcholinesterase (AChE) has been studied using high-level theoretical calculations on a model system that mimics the reaction center of the enzyme, and compared with uncatalyzed acylation reaction. Acetylcholine 13-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 15892689-1 2005 The Electronic-Topological (ETM) and Neural Network methods were applied to the study of the "structure-acetylcholinesterase (AChE) inhibitor activity" relationships for a series of physostigmine and N-benzylpiperidine derivatives. Physostigmine 182-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-124 15892689-1 2005 The Electronic-Topological (ETM) and Neural Network methods were applied to the study of the "structure-acetylcholinesterase (AChE) inhibitor activity" relationships for a series of physostigmine and N-benzylpiperidine derivatives. Physostigmine 182-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 15892689-1 2005 The Electronic-Topological (ETM) and Neural Network methods were applied to the study of the "structure-acetylcholinesterase (AChE) inhibitor activity" relationships for a series of physostigmine and N-benzylpiperidine derivatives. 1-benzylpiperidine 200-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-124 15892689-1 2005 The Electronic-Topological (ETM) and Neural Network methods were applied to the study of the "structure-acetylcholinesterase (AChE) inhibitor activity" relationships for a series of physostigmine and N-benzylpiperidine derivatives. 1-benzylpiperidine 200-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 15739192-1 2005 Acylation of acetylcholine (ACh) catalyzed by acetylcholinesterase (AChE) has been studied using high-level theoretical calculations on a model system that mimics the reaction center of the enzyme, and compared with uncatalyzed acylation reaction. Acetylcholine 13-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 15739192-1 2005 Acylation of acetylcholine (ACh) catalyzed by acetylcholinesterase (AChE) has been studied using high-level theoretical calculations on a model system that mimics the reaction center of the enzyme, and compared with uncatalyzed acylation reaction. Acetylcholine 28-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 15739192-1 2005 Acylation of acetylcholine (ACh) catalyzed by acetylcholinesterase (AChE) has been studied using high-level theoretical calculations on a model system that mimics the reaction center of the enzyme, and compared with uncatalyzed acylation reaction. Acetylcholine 28-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 15792875-1 2005 Ab initio molecular orbital (MO) and hybrid density functional theory (DFT) calculations have been applied to the initial step of the acylation reaction catalyzed by acetylcholinesterase (AChE), which is the nucleophiric addition of Ser200 in catalytic triads to a neurotransmitter acetylcholine (ACh). Acetylcholine 166-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-192 15729675-7 2005 The hydrolysis of acetylcholine (2) by AChE to choline is followed by the [Os(bpy)(2)PyCO(2)H](3+) mediated oxidation of choline to betaine and the concomitant growth of the Au NPs. Acetylcholine 18-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 15729675-7 2005 The hydrolysis of acetylcholine (2) by AChE to choline is followed by the [Os(bpy)(2)PyCO(2)H](3+) mediated oxidation of choline to betaine and the concomitant growth of the Au NPs. Choline 24-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 15729675-7 2005 The hydrolysis of acetylcholine (2) by AChE to choline is followed by the [Os(bpy)(2)PyCO(2)H](3+) mediated oxidation of choline to betaine and the concomitant growth of the Au NPs. Choline 47-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 15729675-7 2005 The hydrolysis of acetylcholine (2) by AChE to choline is followed by the [Os(bpy)(2)PyCO(2)H](3+) mediated oxidation of choline to betaine and the concomitant growth of the Au NPs. Betaine 132-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 15741058-0 2005 Sonochemically fabricated acetylcholinesterase micro-electrode arrays within a flow injection analyser for the determination of organophosphate pesticides. Organophosphates 128-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 15801847-0 2005 N-[18F] fluoroethylpiperidin-4ylmethyl acetate, a novel lipophilic acetylcholine analogue for PET measurement of brain acetylcholinesterase activity. N-fluoroethylpiperidin-4-ylmethyl acetate 0-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 15801847-0 2005 N-[18F] fluoroethylpiperidin-4ylmethyl acetate, a novel lipophilic acetylcholine analogue for PET measurement of brain acetylcholinesterase activity. Acetylcholine 67-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 15801847-1 2005 The reduction of acetylcholinesterase (AChE) activity in the brain has been measured in dementia disorders such as Alzheimer"s disease and dementia with Lewy bodies using (11)C-labeled acetylcholine analogues, N-[(11)C]methylpiperidin-4-yl acetate and propionate, and positron emission tomography (PET). Acetylcholine 17-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 15801847-1 2005 The reduction of acetylcholinesterase (AChE) activity in the brain has been measured in dementia disorders such as Alzheimer"s disease and dementia with Lewy bodies using (11)C-labeled acetylcholine analogues, N-[(11)C]methylpiperidin-4-yl acetate and propionate, and positron emission tomography (PET). N-methylpiperidin-4-yl acetate 210-247 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 15801847-1 2005 The reduction of acetylcholinesterase (AChE) activity in the brain has been measured in dementia disorders such as Alzheimer"s disease and dementia with Lewy bodies using (11)C-labeled acetylcholine analogues, N-[(11)C]methylpiperidin-4-yl acetate and propionate, and positron emission tomography (PET). N-methylpiperidin-4-yl acetate 210-247 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 15801847-1 2005 The reduction of acetylcholinesterase (AChE) activity in the brain has been measured in dementia disorders such as Alzheimer"s disease and dementia with Lewy bodies using (11)C-labeled acetylcholine analogues, N-[(11)C]methylpiperidin-4-yl acetate and propionate, and positron emission tomography (PET). Propionates 252-262 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 15801847-1 2005 The reduction of acetylcholinesterase (AChE) activity in the brain has been measured in dementia disorders such as Alzheimer"s disease and dementia with Lewy bodies using (11)C-labeled acetylcholine analogues, N-[(11)C]methylpiperidin-4-yl acetate and propionate, and positron emission tomography (PET). Propionates 252-262 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 15792875-1 2005 Ab initio molecular orbital (MO) and hybrid density functional theory (DFT) calculations have been applied to the initial step of the acylation reaction catalyzed by acetylcholinesterase (AChE), which is the nucleophiric addition of Ser200 in catalytic triads to a neurotransmitter acetylcholine (ACh). Acetylcholine 188-191 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-186 15833035-0 2005 Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase. organophosphorus 34-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 15833035-0 2005 Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase. Biotin 21-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 15833035-3 2005 Because acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BChE, EC 3.1.1.8) are known to be sensitive targets of OP, their reactivity with FP-biotin was tested. 10-(fluoroethoxyphosphinyl)-N-(biotinamidopentyl)decanamide 156-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-28 15974920-1 2005 Acetylcholinesterase (AChE) plays a crucial physiological role in termination of impulse transmission at cholinergic synapses through rapid hydrolysis of acetylcholine. Acetylcholine 154-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 15974920-1 2005 Acetylcholinesterase (AChE) plays a crucial physiological role in termination of impulse transmission at cholinergic synapses through rapid hydrolysis of acetylcholine. Acetylcholine 154-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 15818530-2 2005 We investigate the cost-effectiveness of the AChE inhibitor Galantamine for patients with Alzheimer"s disease (AD) in a German context. Galantamine 60-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 15826103-1 2005 The acetylcholine esterase, AChE, mediated hydrolysis of acetylthiocholine (1) yields a reducing agent thiocholine (2) that stimulates the catalytic enlargement of Au NP seeds in the presence of AuCl(4)(-). Acetylthiocholine 57-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 15826103-1 2005 The acetylcholine esterase, AChE, mediated hydrolysis of acetylthiocholine (1) yields a reducing agent thiocholine (2) that stimulates the catalytic enlargement of Au NP seeds in the presence of AuCl(4)(-). Thiocholine 63-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 15826103-1 2005 The acetylcholine esterase, AChE, mediated hydrolysis of acetylthiocholine (1) yields a reducing agent thiocholine (2) that stimulates the catalytic enlargement of Au NP seeds in the presence of AuCl(4)(-). gold chloride 195-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 15826103-3 2005 The catalytic growth of the Au NPs is inhibited by 1,5-bis(4-allyldimethylammoniumphenyl)pentane-3-one dibromide (3) or by diethyl p-nitrophenyl phosphate (paraoxon; 4), thus enabling a colorimetric test for AChE inhibitors. Gold 28-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-212 15826103-3 2005 The catalytic growth of the Au NPs is inhibited by 1,5-bis(4-allyldimethylammoniumphenyl)pentane-3-one dibromide (3) or by diethyl p-nitrophenyl phosphate (paraoxon; 4), thus enabling a colorimetric test for AChE inhibitors. 1,5-bis(4-allyldimethylammoniumphenyl)pentane-3-one dibromide 51-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-212 15818530-5 2005 RESULTS: In the base case, the application of the AChE inhibitor Galantamine is a dominant scenario with cost savings along with gained quality adjusted life years. Galantamine 65-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 15681196-2 2005 Urease and acetylcholinesterase (AChE) were used as model enzymes and were co-entrapped with the sensing probe, FITC-dextran, in the sol-gel matrix to measure pH, urea, acetylcholine (ACh) and heavy metals (enzyme inhibitors). Urea 163-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 15681196-2 2005 Urease and acetylcholinesterase (AChE) were used as model enzymes and were co-entrapped with the sensing probe, FITC-dextran, in the sol-gel matrix to measure pH, urea, acetylcholine (ACh) and heavy metals (enzyme inhibitors). Acetylcholine 11-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 15681196-2 2005 Urease and acetylcholinesterase (AChE) were used as model enzymes and were co-entrapped with the sensing probe, FITC-dextran, in the sol-gel matrix to measure pH, urea, acetylcholine (ACh) and heavy metals (enzyme inhibitors). Acetylcholine 33-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 15762562-0 2005 Acetylcholinesterase-based organophosphate nerve agent sensing photonic crystal. Organophosphates 27-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 15762562-3 2005 The molecular recognition agent for the sensor is the enzyme acetylcholinesterase (AChE), which binds organophosphorus compounds irreversibly, creating an anionic phosphonyl species. Organophosphorus Compounds 102-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 15762562-3 2005 The molecular recognition agent for the sensor is the enzyme acetylcholinesterase (AChE), which binds organophosphorus compounds irreversibly, creating an anionic phosphonyl species. Organophosphorus Compounds 102-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 15740071-0 2005 Inhibition of acetylcholinesterase activity by bicyclic monoterpenoids. Monoterpenes 56-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 15740071-1 2005 Inhibition of acetylcholinesterase (AChE) activity by 17 kinds of bicyclic monoterpenoids was investigated. Monoterpenes 75-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 15740071-1 2005 Inhibition of acetylcholinesterase (AChE) activity by 17 kinds of bicyclic monoterpenoids was investigated. Monoterpenes 75-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 15740071-5 2005 (+)- and (-)-alpha-pinene and (+)-3-carene were potent inhibitors of AChE. (+)- and (-)-alpha-pinene 0-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 15740071-5 2005 (+)- and (-)-alpha-pinene and (+)-3-carene were potent inhibitors of AChE. 3-carene 30-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 15596427-0 2005 Acetylcholinesterase inhibitors for the treatment of Wernicke-Korsakoff syndrome--three further cases show response to donepezil. Donepezil 119-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 15596427-1 2005 Three patients diagnosed with Wernicke-Korsakoff syndrome were treated with the acetylcholinesterase inhibitor, donepezil, for periods of 6 to 8 months. Donepezil 112-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 15715468-4 2005 Because the two series of carbamates (7-12) differ in their phenolic moieties, their respective potency and selectivity for AChE versus BChE was governed by their N-substituted groups. Carbamates 26-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 15681196-2 2005 Urease and acetylcholinesterase (AChE) were used as model enzymes and were co-entrapped with the sensing probe, FITC-dextran, in the sol-gel matrix to measure pH, urea, acetylcholine (ACh) and heavy metals (enzyme inhibitors). fluorescein isothiocyanate dextran 112-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 15763393-2 2005 One strategy for treatment of AD has been to use acetylcholinesterase (AChE) inhibitors to increase the levels of acetylcholine and enhancing cholinergic activity in the affected regions of the brain. Acetylcholine 49-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 15715671-1 2005 The 5.5 Mb chromosome 7q21-22 ACHE/PON1 locus harbours the ACHE gene encoding the acetylcholine hydrolyzing, organophosphate (OP)-inhibitable acetylcholinesterase protein and the paraoxonase gene PON1, yielding the OP-hydrolyzing PON1 enzyme which also displays arylesterase activity. Acetylcholine 82-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 15715671-1 2005 The 5.5 Mb chromosome 7q21-22 ACHE/PON1 locus harbours the ACHE gene encoding the acetylcholine hydrolyzing, organophosphate (OP)-inhibitable acetylcholinesterase protein and the paraoxonase gene PON1, yielding the OP-hydrolyzing PON1 enzyme which also displays arylesterase activity. Acetylcholine 82-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 15715671-1 2005 The 5.5 Mb chromosome 7q21-22 ACHE/PON1 locus harbours the ACHE gene encoding the acetylcholine hydrolyzing, organophosphate (OP)-inhibitable acetylcholinesterase protein and the paraoxonase gene PON1, yielding the OP-hydrolyzing PON1 enzyme which also displays arylesterase activity. Organophosphates 109-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 15715671-1 2005 The 5.5 Mb chromosome 7q21-22 ACHE/PON1 locus harbours the ACHE gene encoding the acetylcholine hydrolyzing, organophosphate (OP)-inhibitable acetylcholinesterase protein and the paraoxonase gene PON1, yielding the OP-hydrolyzing PON1 enzyme which also displays arylesterase activity. Organophosphates 109-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 15715671-1 2005 The 5.5 Mb chromosome 7q21-22 ACHE/PON1 locus harbours the ACHE gene encoding the acetylcholine hydrolyzing, organophosphate (OP)-inhibitable acetylcholinesterase protein and the paraoxonase gene PON1, yielding the OP-hydrolyzing PON1 enzyme which also displays arylesterase activity. Organophosphates 109-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 15716518-3 2005 RESULTS: Analysis of the PET data revealed mean (temporal, parietal, and frontal) cortical donepezil induced AChE inhibition of 19.1% (SD 9.4%) (t = -7.9; p<0.0001). Donepezil 91-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 15716518-5 2005 Donepezil induced cortical inhibition of AChE activity correlated with changes in the Stroop Color Word interference scores (R(2) = 0.59, p<0.01), but not with primary memory test scores. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 15716518-7 2005 CONCLUSIONS: Donepezil induced inhibition of cortical AChE enzyme activity is modest in patients with mild AD. Donepezil 13-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 16335248-0 2005 [Effect of some isoquinoline alkaloids on enzymatic activity of acetylcholinesterase and monoamine oxidase]. isoquinoline alkaloids 16-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 16335248-1 2005 It has been shown, that some benzo[c]-phenanthridine and diisoquinoline alkaloids isolated from Chelidonium majus L. and Macleaya (Bocconia) cordata and M. microcarpa (berberine, sanguinarine, chelidonine) and of drugs ("Ukrain" and "Sanguirythrine") inhibited the enzyme activity of acetylcholinesterase from human erythrocyte and monoamine oxidase from the rat liver. diisoquinoline alkaloids 57-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 284-304 16335248-1 2005 It has been shown, that some benzo[c]-phenanthridine and diisoquinoline alkaloids isolated from Chelidonium majus L. and Macleaya (Bocconia) cordata and M. microcarpa (berberine, sanguinarine, chelidonine) and of drugs ("Ukrain" and "Sanguirythrine") inhibited the enzyme activity of acetylcholinesterase from human erythrocyte and monoamine oxidase from the rat liver. Berberine 168-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 284-304 15686892-0 2005 A rate determining step change in the pre-steady state of acetylcholinesterase inhibitions by 1,n-alkane-di-N-butylcarbamates. 1,n-alkane-di-n-butylcarbamates 94-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 15704966-5 2005 This method was further applied to the synthesis of 1-tetralones, 1-benzosuberones, and the potent acetylcholinesterase inhibitor donepezil. 1-tetralones 52-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 15704966-5 2005 This method was further applied to the synthesis of 1-tetralones, 1-benzosuberones, and the potent acetylcholinesterase inhibitor donepezil. 1-benzosuberones 66-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 15704966-5 2005 This method was further applied to the synthesis of 1-tetralones, 1-benzosuberones, and the potent acetylcholinesterase inhibitor donepezil. Donepezil 130-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 15792266-8 2005 These include combinations of carbamates (reversible AChE inhibitors) and central anticholinergics or NMDA receptor antagonists, benzodiazepines or partial agonists for benzodiazepine receptor, and other central AChE inhibitors approved for Alzheimer"s disease. Carbamates 30-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 15670925-0 2005 Synthesis, acetylcholinesterase inhibition and neuroprotective activity of new tacrine analogues. Tacrine 79-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 15686892-1 2005 Alkane-1-N-butylcarbamate-n-ols (1-7) and 1,n-alkane-di-N-butylcarbamates (8-14) are potent pseudo-substrate inhibitors of acetylcholinesterase. alkane-1-n-butylcarbamate-n-ols 0-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-143 15686892-1 2005 Alkane-1-N-butylcarbamate-n-ols (1-7) and 1,n-alkane-di-N-butylcarbamates (8-14) are potent pseudo-substrate inhibitors of acetylcholinesterase. 1,n-alkane-di-n-butylcarbamates 42-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-143 15689148-1 2005 By targeting dual active sites of AChE, a series of bis-huperzine B analogues with various lengths of the tether were designed, synthesized, and tested for their inhibition and selectivity. bis-huperzine b 52-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 15689148-2 2005 The most potent bis-huperzine B (5g) exhibited 3900-fold increase in AChE inhibition and 930-fold greater in selectivity for AChE vs BuChE than its parent huperzine B. bis-huperzine b 16-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 15689148-2 2005 The most potent bis-huperzine B (5g) exhibited 3900-fold increase in AChE inhibition and 930-fold greater in selectivity for AChE vs BuChE than its parent huperzine B. bis-huperzine b 16-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 15689148-2 2005 The most potent bis-huperzine B (5g) exhibited 3900-fold increase in AChE inhibition and 930-fold greater in selectivity for AChE vs BuChE than its parent huperzine B. huperzine B 20-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 15689148-2 2005 The most potent bis-huperzine B (5g) exhibited 3900-fold increase in AChE inhibition and 930-fold greater in selectivity for AChE vs BuChE than its parent huperzine B. huperzine B 20-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 15895683-0 2005 Synthesis and inhibitory potential towards acetylcholinesterase, butyrylcholinesterase and lipoxygenase of some variably substituted chalcones. Chalcones 133-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 15666354-2 2005 Acetylcholinesterase (AChE) hydrolyses acetylcholine (ACh) ensuring the fast clearance of released neurotransmitter at cholinergic synapses. Acetylcholine 39-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 15666354-2 2005 Acetylcholinesterase (AChE) hydrolyses acetylcholine (ACh) ensuring the fast clearance of released neurotransmitter at cholinergic synapses. Acetylcholine 39-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 15666354-2 2005 Acetylcholinesterase (AChE) hydrolyses acetylcholine (ACh) ensuring the fast clearance of released neurotransmitter at cholinergic synapses. Acetylcholine 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 15895683-2 2005 It was observed that some of these compounds have the potential to inhibit acetylcholinesterase, whereas others show activity against butyrylcholinesterase, depending on the substitution pattern at the two aromatic rings of these chalcones. Chalcones 230-239 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 15582466-8 2005 This study describes two distinct mechanisms for binding phenothiazine amide derivatives to BuChE and AChE. phenothiazine amide 57-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 15654704-2 2005 Standard treatment involves administration of intravenous atropine and oxime to counter acetylcholinesterase inhibition at the synapse. Atropine 58-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 15654704-2 2005 Standard treatment involves administration of intravenous atropine and oxime to counter acetylcholinesterase inhibition at the synapse. Oximes 71-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 15659242-1 2005 BACKGROUND: Rivastigmine, a butyl- and acetylcholinesterase inhibitor, is approved for symptomatic treatment of Alzheimer"s disease (AD). Rivastigmine 12-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-59 15633997-0 2005 Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation. Propidium 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 15633997-0 2005 Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation. Propidium 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 15633997-0 2005 Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation. Polyamines 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 15633997-0 2005 Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation. Polyamines 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 15525694-1 2005 The classical laboratory tests for exposure to organophosphorus toxicants (OP) are inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity in blood. organophosphorus 47-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 15525694-1 2005 The classical laboratory tests for exposure to organophosphorus toxicants (OP) are inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity in blood. organophosphorus 47-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 15658850-2 2005 Lipocrine is the first compound that inhibits the catalytic activity of AChE and AChE-induced amyloid-beta aggregation and protects against reactive oxygen species. lipocrine 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 15658850-2 2005 Lipocrine is the first compound that inhibits the catalytic activity of AChE and AChE-induced amyloid-beta aggregation and protects against reactive oxygen species. lipocrine 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 15674800-0 2005 Synthesis and biological evaluation of tacrine-thiadiazolidinone hybrids as dual acetylcholinesterase inhibitors. Tacrine 39-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 15674800-0 2005 Synthesis and biological evaluation of tacrine-thiadiazolidinone hybrids as dual acetylcholinesterase inhibitors. Thiadiazolidinone 47-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 15674800-4 2005 Competition assays using propidium as reference of selective ligand for the peripheral anionic site on acetylcholinesterase indicates the influence of the designed compounds over the peripheral site. Propidium 25-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 16097393-4 2005 Acetylcholinesterase activity (AChE) is highly sensitive to organophosphorus and carbamate insecticides and, to some extent, also to heavy metals. organophosphorus 60-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 16097393-4 2005 Acetylcholinesterase activity (AChE) is highly sensitive to organophosphorus and carbamate insecticides and, to some extent, also to heavy metals. organophosphorus 60-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 16097393-4 2005 Acetylcholinesterase activity (AChE) is highly sensitive to organophosphorus and carbamate insecticides and, to some extent, also to heavy metals. Carbamates 81-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 16097393-4 2005 Acetylcholinesterase activity (AChE) is highly sensitive to organophosphorus and carbamate insecticides and, to some extent, also to heavy metals. Carbamates 81-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 15611638-0 2005 Novel assay utilizing fluorochrome-tagged physostigmine (Ph-F) to in situ detect active acetylcholinesterase (AChE) induced during apoptosis. Physostigmine 42-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 15611638-0 2005 Novel assay utilizing fluorochrome-tagged physostigmine (Ph-F) to in situ detect active acetylcholinesterase (AChE) induced during apoptosis. Physostigmine 42-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 15611638-2 2005 To obtain a marker of active AChE that could assay this enzyme in live intact cells and be applicable to fluorescence microscopy and cytometry, the fluorescein-tagged physostigmine (Ph-F), high affinity ligand (inhibitor) reactive with the active center of AChE, was constructed and tested for its ability to in situ label AChE and measure its induction during apoptosis. Fluorescein 148-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 15611638-2 2005 To obtain a marker of active AChE that could assay this enzyme in live intact cells and be applicable to fluorescence microscopy and cytometry, the fluorescein-tagged physostigmine (Ph-F), high affinity ligand (inhibitor) reactive with the active center of AChE, was constructed and tested for its ability to in situ label AChE and measure its induction during apoptosis. Fluorescein 148-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 257-261 15611638-2 2005 To obtain a marker of active AChE that could assay this enzyme in live intact cells and be applicable to fluorescence microscopy and cytometry, the fluorescein-tagged physostigmine (Ph-F), high affinity ligand (inhibitor) reactive with the active center of AChE, was constructed and tested for its ability to in situ label AChE and measure its induction during apoptosis. Fluorescein 148-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 257-261 15611638-2 2005 To obtain a marker of active AChE that could assay this enzyme in live intact cells and be applicable to fluorescence microscopy and cytometry, the fluorescein-tagged physostigmine (Ph-F), high affinity ligand (inhibitor) reactive with the active center of AChE, was constructed and tested for its ability to in situ label AChE and measure its induction during apoptosis. Physostigmine 167-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 15610710-4 2005 Acetylcholinesterase inhibitors such as pyridostigmine or neostigmine are the preferred first-line treatment for ocular myasthenia gravis, with mild cases requiring no additional intervention. Pyridostigmine Bromide 40-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 15610710-4 2005 Acetylcholinesterase inhibitors such as pyridostigmine or neostigmine are the preferred first-line treatment for ocular myasthenia gravis, with mild cases requiring no additional intervention. Neostigmine 58-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 16298876-1 2005 The current study examined the ability of antimalarials chloroquine (CQ), primaquine (PQ), and quinine (Q) to inhibit human erythrocyte membrane acetylcholinesterase (AChE) and the mechanisms underlying their inhibitory action. Chloroquine 56-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 16192723-2 2005 The objective of this study was to determine if treatment with donepezil, an acetylcholinesterase inhibitor, may provide benefit for VaD patients. Donepezil 63-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 16298876-1 2005 The current study examined the ability of antimalarials chloroquine (CQ), primaquine (PQ), and quinine (Q) to inhibit human erythrocyte membrane acetylcholinesterase (AChE) and the mechanisms underlying their inhibitory action. Chloroquine 56-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 16298876-1 2005 The current study examined the ability of antimalarials chloroquine (CQ), primaquine (PQ), and quinine (Q) to inhibit human erythrocyte membrane acetylcholinesterase (AChE) and the mechanisms underlying their inhibitory action. Chloroquine 69-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 16298876-1 2005 The current study examined the ability of antimalarials chloroquine (CQ), primaquine (PQ), and quinine (Q) to inhibit human erythrocyte membrane acetylcholinesterase (AChE) and the mechanisms underlying their inhibitory action. Primaquine 74-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 16298876-1 2005 The current study examined the ability of antimalarials chloroquine (CQ), primaquine (PQ), and quinine (Q) to inhibit human erythrocyte membrane acetylcholinesterase (AChE) and the mechanisms underlying their inhibitory action. Primaquine 74-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 16298876-1 2005 The current study examined the ability of antimalarials chloroquine (CQ), primaquine (PQ), and quinine (Q) to inhibit human erythrocyte membrane acetylcholinesterase (AChE) and the mechanisms underlying their inhibitory action. Primaquine 86-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 16298876-1 2005 The current study examined the ability of antimalarials chloroquine (CQ), primaquine (PQ), and quinine (Q) to inhibit human erythrocyte membrane acetylcholinesterase (AChE) and the mechanisms underlying their inhibitory action. Primaquine 86-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 16114264-2 2005 A short proline rich sequence in the N-terminal domain of ColQ or PRiMA associates four C-terminal extension of AChE or BChE. Proline 8-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 16173062-0 2005 Probing the peripheral anionic site of acetylcholinesterase with quantitative structure activity relationships for inhibition by biphenyl-4-acyoxylate-4"-N-Butylcarbamates. biphenyl-4-acyoxylate-4"-n-butylcarbamates 129-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 16173062-1 2005 Biphenyl-4-acyoxylate-4"-N-butylcarbamates 1-8 are synthesized from 4,4"-biphenol and are characterized as the pseudosubstrate inhibitors of acetylcholinesterase. biphenyl-4-acyoxylate-4"-n-butylcarbamates 1-8 0-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 16173062-1 2005 Biphenyl-4-acyoxylate-4"-N-butylcarbamates 1-8 are synthesized from 4,4"-biphenol and are characterized as the pseudosubstrate inhibitors of acetylcholinesterase. 4,4'-dihydroxybiphenyl 68-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 16114264-8 2005 The clusterisation of AChE depends upon ColQ through three sites of interactions: two different heparin binding domains in the collagen domain interact with heparan sulfate proteoglycan particularly the perlecan and the C-terminal non collagenic domain interacts with MuSK, the tyrosine kinase receptor organiser of the neuromuscular junction. Heparin 96-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 15956816-8 2005 It is also possible that the non-catalytic function of AChE is involved in neuroprotective effects of HupA. huperzine A 102-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 15787237-4 2005 Graphislactone A and botrallin presented a moderate activity towards AChE, with IC50 of 8.1 and 6.1 microg/ml (27 and 19 microM, respectively). Graphislactone A 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 20021089-3 2005 We have confirmed the fact that currently the most promising AChE reactivator, HI-6, is the most effective reactivator of sarin-inhibited AChE. asoxime chloride 79-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 20021089-3 2005 We have confirmed the fact that currently the most promising AChE reactivator, HI-6, is the most effective reactivator of sarin-inhibited AChE. asoxime chloride 79-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 20021089-4 2005 There are only three AChE reactivators-HI-6, TO033 and TO047-able to satisfactorily reactivate sarin-inhibited AChE at the concentration 10(-5) M, which is nontoxic for human use. asoxime chloride 39-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 20021089-4 2005 There are only three AChE reactivators-HI-6, TO033 and TO047-able to satisfactorily reactivate sarin-inhibited AChE at the concentration 10(-5) M, which is nontoxic for human use. asoxime chloride 39-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 15787237-4 2005 Graphislactone A and botrallin presented a moderate activity towards AChE, with IC50 of 8.1 and 6.1 microg/ml (27 and 19 microM, respectively). botrallin 21-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 15588084-8 2004 Clearly, the ability of an AChE inhibitor, based on a linear polyamine backbone, to bind both AChE sites may not be a sufficient condition to inhibit also AChE-induced Abeta aggregation. Polyamines 61-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 15588084-8 2004 Clearly, the ability of an AChE inhibitor, based on a linear polyamine backbone, to bind both AChE sites may not be a sufficient condition to inhibit also AChE-induced Abeta aggregation. Polyamines 61-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 15588084-8 2004 Clearly, the ability of an AChE inhibitor, based on a linear polyamine backbone, to bind both AChE sites may not be a sufficient condition to inhibit also AChE-induced Abeta aggregation. Polyamines 61-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 15909954-0 2004 Synthesis of novel N-alkyl carbamates of a-substituted amides of g-hydroxybutyric acid as potential acetylcholinesterase inhibitors. n-alkyl carbamates 19-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 15909954-0 2004 Synthesis of novel N-alkyl carbamates of a-substituted amides of g-hydroxybutyric acid as potential acetylcholinesterase inhibitors. Amides 55-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 15909954-0 2004 Synthesis of novel N-alkyl carbamates of a-substituted amides of g-hydroxybutyric acid as potential acetylcholinesterase inhibitors. Hydroxybutyrates 65-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 15633941-1 2004 The goal of this study was to determine whether rivastigmine, a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), has any effect on delirium in vascular dementia (VaD). Rivastigmine 48-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 15588084-3 2004 In the present paper we expanded SAR studies of 3, the ethyl analogue of the AChE inhibitor caproctamine (2), by investigating the role of its octamethylene spacer separating the two amide functions through the replacement with dipiperidine and dianiline moieties. caproctamine 92-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 15498514-0 2004 Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes. organophosphorus 92-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 15498514-0 2004 Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes. Oximes 123-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 15498514-3 2004 Reactivators (oximes) of inhibited AChE are a mainstay of treatment, however, the commercially available compounds, obidoxime and pralidoxime, are considered to be rather ineffective against various nerve agents. Oximes 14-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 15498514-5 2004 However, the various interactions between AChE, OP and oximes can be investigated with human AChE which enables the direct assessment of oxime potency, thus excluding species differences. Oximes 55-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 15498514-5 2004 However, the various interactions between AChE, OP and oximes can be investigated with human AChE which enables the direct assessment of oxime potency, thus excluding species differences. Oximes 55-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 15498514-7 2004 The inhibitory potency of OPs, reactivating potency of oximes and spontaneous reactivation and aging were strongly affected by the structural characteristics of the OPs and of the phosphyl-AChE-complex. Oximes 55-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-193 15498514-9 2004 AChE inhibited by various phosphoramidates was mostly resistant towards reactivation by oximes while phosphonylated AChE was easily reactivated. phosphoramidic acid 26-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 15498514-9 2004 AChE inhibited by various phosphoramidates was mostly resistant towards reactivation by oximes while phosphonylated AChE was easily reactivated. Oximes 88-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 15498514-10 2004 HLo 7 was most potent with phosphonylated AChE and obidoxime with AChE inhibited by organophosphates and phosphoramidates. Obidoxime Chloride 51-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 15498514-10 2004 HLo 7 was most potent with phosphonylated AChE and obidoxime with AChE inhibited by organophosphates and phosphoramidates. Organophosphates 84-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 15498514-10 2004 HLo 7 was most potent with phosphonylated AChE and obidoxime with AChE inhibited by organophosphates and phosphoramidates. phosphoramidic acid 105-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 15522688-0 2004 The effect of polyamidoamine dendrimers on human erythrocyte membrane acetylcholinesterase activity. Poly(amidoamine) 14-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 15522688-1 2004 Polyamidoamine (PAMAM) dendrimers impact on activity of acetylcholinesterase was studied. Poly(amidoamine) 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 15522688-1 2004 Polyamidoamine (PAMAM) dendrimers impact on activity of acetylcholinesterase was studied. Poly(amidoamine) 16-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 15522688-3 2004 It may be due to two types of interactions: direct--between dendrimers and the enzyme; indirect--via a modification of the physical state of membrane phospholipids affecting the acetylcholinesterase. Phospholipids 150-163 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-198 22034396-2 2004 Randomized clinical trials comparing the acetylcholinesterase inhibitor donepezil with placebo have shown some symptomatic benefit on (i) cognition in one short-term (6-month) study; and (ii)conversion to dementia in one long-term (3-year) study, but not for the full duration of the study, except in subjects with the apolipoprotein E4 (APOE-4) mutation, in whoom the benefit was sustained throughout the 3 years. Donepezil 72-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 15567429-0 2004 Novel neuronal targets for the acetylcholinesterase inhibitor donepezil. Donepezil 62-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 15567429-1 2004 The effects of the acetylcholinesterase inhibitor donepezil on cell viability and proliferation events have been analysed in SH-SY5Y human neuroblastoma cells. Donepezil 50-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 15537349-1 2004 Rivastigmine (1), an acetylcholinesterase (AChE) inhibitor approved in 2000 for the treatment of Alzheimer disease, bears a carbamate moiety in its structure, which is able to react covalently with the active site of the enzyme. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 15537349-1 2004 Rivastigmine (1), an acetylcholinesterase (AChE) inhibitor approved in 2000 for the treatment of Alzheimer disease, bears a carbamate moiety in its structure, which is able to react covalently with the active site of the enzyme. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 15537349-1 2004 Rivastigmine (1), an acetylcholinesterase (AChE) inhibitor approved in 2000 for the treatment of Alzheimer disease, bears a carbamate moiety in its structure, which is able to react covalently with the active site of the enzyme. Carbamates 124-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 15537349-1 2004 Rivastigmine (1), an acetylcholinesterase (AChE) inhibitor approved in 2000 for the treatment of Alzheimer disease, bears a carbamate moiety in its structure, which is able to react covalently with the active site of the enzyme. Carbamates 124-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 15537349-3 2004 On the basis of these findings and in connection with our previous studies on a series of benzopyrano[4,3-b]pyrrole carbamates as AChE inhibitors, we designed a series of conformationally restricted analogues of 1 by including the dimethylamino-alpha-methylbenzyl moiety in different tricyclic systems. benzopyrano[4,3-b]pyrrole carbamates 90-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 15496218-15 2004 CONCLUSIONS: The results of this study suggest that patients with AD and mild to moderate hepatic impairment (Child-Pugh grade A or B) can be safely given donepezil 5 mg once daily and that this dose is associated with a nonsignificantly higher AChE inhibition than age-matched volunteers. Donepezil 155-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 245-249 15522601-0 2004 Development of acetylcholinesterase silica sol-gel immobilized biosensor--an application towards oxydemeton methyl detection. Silicon Dioxide 36-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 15522601-1 2004 An amperometric silica sol-gel film immobilized biosensor doped with acetylcholinesterase was fabricated in the laboratory finding application in organophosphate detection based on enzyme inhibition. Silicon Dioxide 16-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 15522601-1 2004 An amperometric silica sol-gel film immobilized biosensor doped with acetylcholinesterase was fabricated in the laboratory finding application in organophosphate detection based on enzyme inhibition. Organophosphates 146-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 15536465-0 2004 Inhibition of acetylcholinesterase in patients receiving irinotecan (camptothecin-11). Irinotecan 57-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 15536465-0 2004 Inhibition of acetylcholinesterase in patients receiving irinotecan (camptothecin-11). Irinotecan 69-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 15351315-1 2004 The current pretreatment against nerve agent poisoning deployed by the UK and US armed forces is the acetylcholinesterase (EC 3.1.1.7) inhibitor pyridostigmine bromide (PB). Pyridostigmine Bromide 145-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 15351315-1 2004 The current pretreatment against nerve agent poisoning deployed by the UK and US armed forces is the acetylcholinesterase (EC 3.1.1.7) inhibitor pyridostigmine bromide (PB). Pyridostigmine Bromide 169-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 15351315-10 2004 Physostigmine (PHY), a carbamate compound similar to PB, consistently showed inhibition of T-cell activation, but only at concentrations in excess of those required to inhibit AChE. Physostigmine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 15351315-10 2004 Physostigmine (PHY), a carbamate compound similar to PB, consistently showed inhibition of T-cell activation, but only at concentrations in excess of those required to inhibit AChE. Physostigmine 15-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 15459952-1 2004 Acetylcholinesterase (AChE) plays a crucial physiological role in termination of impulse transmission at cholinergic synapses through rapid hydrolysis of acetylcholine. Acetylcholine 154-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 15459952-1 2004 Acetylcholinesterase (AChE) plays a crucial physiological role in termination of impulse transmission at cholinergic synapses through rapid hydrolysis of acetylcholine. Acetylcholine 154-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 15486516-2 2004 Because rivastigmine, a reversible acetylcholinesterase inhibitor, appears to delay the progression of Alzheimer"s disease, it may also improve or delay the cognitive and behavioural disturbances evident in elderly chronic schizophrenia patients with comorbid cognitive decline. Rivastigmine 8-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 15465282-7 2004 Peripheral stimuli-induced modulations in acetylcholine regulation may hence reflect blood cell lineage-dependent acetylcholinesterase splice variations. Acetylcholine 42-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 15551380-9 2004 These results demonstrated that acetylcholine and choline modulate nitric oxide metabolites on erythrocytes and this effect is mediated by interactions with erythrocyte membrane muscarinic receptors and membrane enzyme acetylcholinesterase. Acetylcholine 32-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 219-239 15551380-9 2004 These results demonstrated that acetylcholine and choline modulate nitric oxide metabolites on erythrocytes and this effect is mediated by interactions with erythrocyte membrane muscarinic receptors and membrane enzyme acetylcholinesterase. Choline 38-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 219-239 15551380-9 2004 These results demonstrated that acetylcholine and choline modulate nitric oxide metabolites on erythrocytes and this effect is mediated by interactions with erythrocyte membrane muscarinic receptors and membrane enzyme acetylcholinesterase. Nitric Oxide 67-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 219-239 15569517-6 2004 Partial correlation analysis suggested that there existed negative correlation between activity of AChE in the RBC and plasma level of LPO (r = -0.274, P = 0.013) and positive correlation between activity of AChE in the RBC and plasma levels of VC and VE, and activity of SOD in the RBC (r = 0.333, P = 0.002, r = 0.269, P = 0.015 and r = 0.248, P = 0.026, respectively) in the ADPP, adjusted for age. Lipid Peroxides 135-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 15569517-6 2004 Partial correlation analysis suggested that there existed negative correlation between activity of AChE in the RBC and plasma level of LPO (r = -0.274, P = 0.013) and positive correlation between activity of AChE in the RBC and plasma levels of VC and VE, and activity of SOD in the RBC (r = 0.333, P = 0.002, r = 0.269, P = 0.015 and r = 0.248, P = 0.026, respectively) in the ADPP, adjusted for age. adpp 378-382 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 15514903-3 2004 Organophosphorus insecticides and warfare nerve agents exert their main toxicological effects through inhibition of acetylcholinesterase. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 15514903-4 2004 Current treatments of patients poisoned with organophosphorus compounds include atropine (in order to protect muscarinic receptors), oximes (in order to accelerate the reactivation of the inhibited acetylcholinesterase) and benzodiazepines (in order to avoid convulsions). organophosphorus 45-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-218 15514903-4 2004 Current treatments of patients poisoned with organophosphorus compounds include atropine (in order to protect muscarinic receptors), oximes (in order to accelerate the reactivation of the inhibited acetylcholinesterase) and benzodiazepines (in order to avoid convulsions). Oximes 133-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-218 15494248-7 2004 Acetylcholinesterase is used to detect organophosphorous and carbamate insecticide residues but several molecules (reversible inhibitors, pH and ionic strength modifiers) generate matrix effects in free conditions. organophosphorous 39-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 15494248-7 2004 Acetylcholinesterase is used to detect organophosphorous and carbamate insecticide residues but several molecules (reversible inhibitors, pH and ionic strength modifiers) generate matrix effects in free conditions. Carbamates 61-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 15483114-2 2004 The noncatalytic functions of AChE have been attributed to its peripheral anionic site (PAS)-mediated protein-protein interactions. Aminosalicylic Acid 88-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 15483114-9 2004 Moreover, the PAS blockade-induced glutamatergic impairments were associated with a depressed expression of beta-neurexins and an accumulation of other synaptic proteins, including neuroligins, and were mostly preventable by antisense suppression of AChE expression. Aminosalicylic Acid 14-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 250-254 15648653-0 2004 Ortho effects in quantitative structure-activity relationships for acetylcholinesterase inhibition by aryl carbamates. aryl carbamates 102-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 15381312-1 2004 The X-ray crystal structure of the reaction product of acetylcholinesterase (AChE) with the inhibitor diisopropylphosphorofluoridate (DFP) showed significant structural displacement in a loop segment of residues 287-290. Isoflurophate 102-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 15381312-1 2004 The X-ray crystal structure of the reaction product of acetylcholinesterase (AChE) with the inhibitor diisopropylphosphorofluoridate (DFP) showed significant structural displacement in a loop segment of residues 287-290. Isoflurophate 102-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 15381312-1 2004 The X-ray crystal structure of the reaction product of acetylcholinesterase (AChE) with the inhibitor diisopropylphosphorofluoridate (DFP) showed significant structural displacement in a loop segment of residues 287-290. Isoflurophate 134-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 15381312-1 2004 The X-ray crystal structure of the reaction product of acetylcholinesterase (AChE) with the inhibitor diisopropylphosphorofluoridate (DFP) showed significant structural displacement in a loop segment of residues 287-290. Isoflurophate 134-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 15648653-1 2004 Ortho-substituted phenyl-N-butyl carbamates (1-9) are characterized as "pseudo-pseudo-substrate" inhibitors of acetylcholinesterase. phenyl-n-butyl carbamates 18-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 15648654-0 2004 Acetylcholinesterase inhibition by diaza- and dioxophosphole compounds: synthesis and determination of IC50 values. diaza- and dioxophosphole 35-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 15648654-4 2004 In this study, the inhibitory potency of two isoelectronic and isostructural diaza- and dioxophospholes A (CH3C6H3 O2P(O)Cl) and B (CH3C6H3(NH)2P(O)Cl) against human acetylcholinesterase (hAChE) was examined by spectrophotometric measurements based on Ellman"s method. ch3c6h3 o2p(o)cl 107-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-186 15648654-4 2004 In this study, the inhibitory potency of two isoelectronic and isostructural diaza- and dioxophospholes A (CH3C6H3 O2P(O)Cl) and B (CH3C6H3(NH)2P(O)Cl) against human acetylcholinesterase (hAChE) was examined by spectrophotometric measurements based on Ellman"s method. ch3c6h3 o2p(o)cl 107-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-193 15648654-4 2004 In this study, the inhibitory potency of two isoelectronic and isostructural diaza- and dioxophospholes A (CH3C6H3 O2P(O)Cl) and B (CH3C6H3(NH)2P(O)Cl) against human acetylcholinesterase (hAChE) was examined by spectrophotometric measurements based on Ellman"s method. (ch3c6h3(nh)2p(o)cl 131-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-186 15616167-2 2004 Changes in the acetylcholine system have been reported in brains of patients with DLB, which provides a rationale for trials of acetylcholinesterase inhibitors in DLB. Acetylcholine 15-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 15544060-0 2004 A comparison of the efficacy of a bispyridinium oxime--1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods. bispyridinium oxime--1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide 34-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 190-210 15544060-1 2004 The efficacy of a bispyridinium oxime 1,4-bis(2-hydroxyiminomethylpyridinium) butane dibromide, called K033, and of currently used oximes (pralidoxime, obidoxime, oxime HI-6), to reactivate acetylcholinesterase inhibited by various nerve agents (sarin, tabun cyclosarin) was tested by in vitro methods. bispyridinium oxime 1,4-bis(2-hydroxyiminomethylpyridinium) butane dibromide 18-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 190-210 15544060-2 2004 The new oxime K033 was found to be a more efficacious reactivator of sarin or cyclosarin-inhibited acetylcholinesterase than pralidoxime and obidoxime but it did not reach the efficacy of oxime HI-6 in the case of the inhibition of acetylcholinesterase by sarin or cyclosarin. Oximes 8-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 15544060-2 2004 The new oxime K033 was found to be a more efficacious reactivator of sarin or cyclosarin-inhibited acetylcholinesterase than pralidoxime and obidoxime but it did not reach the efficacy of oxime HI-6 in the case of the inhibition of acetylcholinesterase by sarin or cyclosarin. Oximes 8-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 232-252 15544060-2 2004 The new oxime K033 was found to be a more efficacious reactivator of sarin or cyclosarin-inhibited acetylcholinesterase than pralidoxime and obidoxime but it did not reach the efficacy of oxime HI-6 in the case of the inhibition of acetylcholinesterase by sarin or cyclosarin. 4,5-Dichloro-2-octylisothiazol-3(2H)-one 14-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 15544060-2 2004 The new oxime K033 was found to be a more efficacious reactivator of sarin or cyclosarin-inhibited acetylcholinesterase than pralidoxime and obidoxime but it did not reach the efficacy of oxime HI-6 in the case of the inhibition of acetylcholinesterase by sarin or cyclosarin. 4,5-Dichloro-2-octylisothiazol-3(2H)-one 14-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 232-252 15544060-2 2004 The new oxime K033 was found to be a more efficacious reactivator of sarin or cyclosarin-inhibited acetylcholinesterase than pralidoxime and obidoxime but it did not reach the efficacy of oxime HI-6 in the case of the inhibition of acetylcholinesterase by sarin or cyclosarin. cyclohexyl methylphosphonofluoridate 78-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 15544060-3 2004 On the other hand, oxime K033 was more efficacious than oxime HI-6 in reactivating tabun-inhibited acetylcholinesterase. oxime k033 19-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 15544060-3 2004 On the other hand, oxime K033 was more efficacious than oxime HI-6 in reactivating tabun-inhibited acetylcholinesterase. oxime hi-6 56-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 15544060-4 2004 Thus, oxime K033 seems to be a relatively efficacious broad spectrum acetylcholinesterase reactivator and, therefore, could be useful if no information about the type of nerve agent used was available. oxime k033 6-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 15380373-0 2004 Effect of subchronic galantamine treatment on neuronal nicotinic and muscarinic receptor subtypes in transgenic mice overexpressing human acetylcholinesterase. Galantamine 21-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 15304240-10 2004 Within particular conditions, such as in mice nullizygote for AChE or in AD patients at advanced stages of the disease, BuChE may replace AChE in hydrolyzing brain acetylcholine. Acetylcholine 164-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 15304241-1 2004 The therapeutic approach for improving the cognitive function in patients with Alzheimer"s disease (AD) is mainly based on the potentiation of central cholinergic activity and is achieved clinically by the use of acetylcholinesterase (AChE) inhibitors such as tacrine, donepezil, rivastigmine, galantamine and other drugs currently in clinical trials. Tacrine 260-267 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-233 15304241-1 2004 The therapeutic approach for improving the cognitive function in patients with Alzheimer"s disease (AD) is mainly based on the potentiation of central cholinergic activity and is achieved clinically by the use of acetylcholinesterase (AChE) inhibitors such as tacrine, donepezil, rivastigmine, galantamine and other drugs currently in clinical trials. Tacrine 260-267 acetylcholinesterase (Cartwright blood group) Homo sapiens 235-239 15304241-1 2004 The therapeutic approach for improving the cognitive function in patients with Alzheimer"s disease (AD) is mainly based on the potentiation of central cholinergic activity and is achieved clinically by the use of acetylcholinesterase (AChE) inhibitors such as tacrine, donepezil, rivastigmine, galantamine and other drugs currently in clinical trials. Donepezil 269-278 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-233 15304241-1 2004 The therapeutic approach for improving the cognitive function in patients with Alzheimer"s disease (AD) is mainly based on the potentiation of central cholinergic activity and is achieved clinically by the use of acetylcholinesterase (AChE) inhibitors such as tacrine, donepezil, rivastigmine, galantamine and other drugs currently in clinical trials. Donepezil 269-278 acetylcholinesterase (Cartwright blood group) Homo sapiens 235-239 15304241-1 2004 The therapeutic approach for improving the cognitive function in patients with Alzheimer"s disease (AD) is mainly based on the potentiation of central cholinergic activity and is achieved clinically by the use of acetylcholinesterase (AChE) inhibitors such as tacrine, donepezil, rivastigmine, galantamine and other drugs currently in clinical trials. Rivastigmine 280-292 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-233 15304241-1 2004 The therapeutic approach for improving the cognitive function in patients with Alzheimer"s disease (AD) is mainly based on the potentiation of central cholinergic activity and is achieved clinically by the use of acetylcholinesterase (AChE) inhibitors such as tacrine, donepezil, rivastigmine, galantamine and other drugs currently in clinical trials. Rivastigmine 280-292 acetylcholinesterase (Cartwright blood group) Homo sapiens 235-239 15304241-1 2004 The therapeutic approach for improving the cognitive function in patients with Alzheimer"s disease (AD) is mainly based on the potentiation of central cholinergic activity and is achieved clinically by the use of acetylcholinesterase (AChE) inhibitors such as tacrine, donepezil, rivastigmine, galantamine and other drugs currently in clinical trials. Galantamine 294-305 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-233 15304241-1 2004 The therapeutic approach for improving the cognitive function in patients with Alzheimer"s disease (AD) is mainly based on the potentiation of central cholinergic activity and is achieved clinically by the use of acetylcholinesterase (AChE) inhibitors such as tacrine, donepezil, rivastigmine, galantamine and other drugs currently in clinical trials. Galantamine 294-305 acetylcholinesterase (Cartwright blood group) Homo sapiens 235-239 15266045-2 2004 OBJECTIVE: To determine whether an in vivo pharmacokinetic interaction exists between memantine and the acetylcholinesterase (AChE) inhibitor donepezil. Memantine 86-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 15266045-2 2004 OBJECTIVE: To determine whether an in vivo pharmacokinetic interaction exists between memantine and the acetylcholinesterase (AChE) inhibitor donepezil. Memantine 86-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 15266045-2 2004 OBJECTIVE: To determine whether an in vivo pharmacokinetic interaction exists between memantine and the acetylcholinesterase (AChE) inhibitor donepezil. Donepezil 142-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 15266045-7 2004 In addition, AChE inhibition was measured in red blood cells by radiolabeled-enzyme assay following administration of donepezil alone and after a single memantine dose. Donepezil 118-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 15266045-7 2004 In addition, AChE inhibition was measured in red blood cells by radiolabeled-enzyme assay following administration of donepezil alone and after a single memantine dose. Memantine 153-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 15266045-9 2004 Percent maximum inhibition of AChE activity (mean +/- SD) by donepezil was 77.8 +/- 7.3% and not significantly different upon coadministration of a single dose of memantine (81.1 +/- 5.7%). Donepezil 61-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 15526038-0 2004 The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix. polyproline 62-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-33 15526038-1 2004 Functional localization of acetylcholinesterase (AChE) in vertebrate muscle and brain depends on interaction of the tryptophan amphiphilic tetramerization (WAT) sequence, at the C-terminus of its major splice variant (T), with a proline-rich attachment domain (PRAD), of the anchoring proteins, collagenous (ColQ) and proline-rich membrane anchor. Tryptophan 116-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 15526038-1 2004 Functional localization of acetylcholinesterase (AChE) in vertebrate muscle and brain depends on interaction of the tryptophan amphiphilic tetramerization (WAT) sequence, at the C-terminus of its major splice variant (T), with a proline-rich attachment domain (PRAD), of the anchoring proteins, collagenous (ColQ) and proline-rich membrane anchor. Tryptophan 116-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 15526038-1 2004 Functional localization of acetylcholinesterase (AChE) in vertebrate muscle and brain depends on interaction of the tryptophan amphiphilic tetramerization (WAT) sequence, at the C-terminus of its major splice variant (T), with a proline-rich attachment domain (PRAD), of the anchoring proteins, collagenous (ColQ) and proline-rich membrane anchor. Proline 229-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 15526038-1 2004 Functional localization of acetylcholinesterase (AChE) in vertebrate muscle and brain depends on interaction of the tryptophan amphiphilic tetramerization (WAT) sequence, at the C-terminus of its major splice variant (T), with a proline-rich attachment domain (PRAD), of the anchoring proteins, collagenous (ColQ) and proline-rich membrane anchor. Proline 229-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 15526038-1 2004 Functional localization of acetylcholinesterase (AChE) in vertebrate muscle and brain depends on interaction of the tryptophan amphiphilic tetramerization (WAT) sequence, at the C-terminus of its major splice variant (T), with a proline-rich attachment domain (PRAD), of the anchoring proteins, collagenous (ColQ) and proline-rich membrane anchor. Proline 318-325 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 15526038-1 2004 Functional localization of acetylcholinesterase (AChE) in vertebrate muscle and brain depends on interaction of the tryptophan amphiphilic tetramerization (WAT) sequence, at the C-terminus of its major splice variant (T), with a proline-rich attachment domain (PRAD), of the anchoring proteins, collagenous (ColQ) and proline-rich membrane anchor. Proline 318-325 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 15526038-5 2004 Each WAT makes similar but unique interactions, consistent with an asymmetric pattern of disulfide linkages between the AChE tetramer subunits and ColQ. Disulfides 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 15341532-4 2004 In these cells, the activity of AChE is significantly decreased after 2 h of donepezil treatment. Donepezil 77-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 15333988-4 2004 Donepezil suppressed AChE activity, analyzed by [(11)C]MP4A, in all cortical regions in a dose-dependent manner. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 15333988-5 2004 AChE inhibition by donepezil resulted in a dose-dependent increase in acetylcholine levels in the prefrontal cortex as measured by microdialysis. Donepezil 19-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 15333988-5 2004 AChE inhibition by donepezil resulted in a dose-dependent increase in acetylcholine levels in the prefrontal cortex as measured by microdialysis. Acetylcholine 70-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 15333988-8 2004 As evaluated by an oculomotor delayed response task, aged monkeys showed impaired working memory performance compared to young monkeys, and the impaired performance was partly improved by the administration of donepezil, due to the facilitation of the cholinergic neuronal system by AChE inhibition by donepezil. Donepezil 210-219 acetylcholinesterase (Cartwright blood group) Homo sapiens 283-287 16268118-4 2004 Results of this study show that erythrocyte AChE inhibition provides a good biomarker of exposure to organophosphate pesticides in field studies with human populations. Organophosphates 101-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 15379785-0 2004 Specification of the structure of oximes able to reactivate tabun-inhibited acetylcholinesterase. Oximes 34-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 15379785-1 2004 The efficacy of various oximes to reactivate acetylcholinesterase phosphorylated by tabun (O-ethyl-N,N-dimethyl phosphoramidocyanidate) was tested by in vitro and in vivo methods. Oximes 24-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 17191882-6 2004 Furthermore, four xanthones among these xanthones had already been described as monoamine oxidase (MAO) inhibitors, making then dual AChE/MAO inhibitors of great interest. Xanthones 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 15379785-1 2004 The efficacy of various oximes to reactivate acetylcholinesterase phosphorylated by tabun (O-ethyl-N,N-dimethyl phosphoramidocyanidate) was tested by in vitro and in vivo methods. tabun 84-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 15379785-1 2004 The efficacy of various oximes to reactivate acetylcholinesterase phosphorylated by tabun (O-ethyl-N,N-dimethyl phosphoramidocyanidate) was tested by in vitro and in vivo methods. o-ethyl-n,n-dimethyl phosphoramidocyanidate 91-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 15379785-4 2004 In vitro, the concentration of trimedoxime corresponding to 1.0 mmol/l was able to reach 50% reactivation of tabun-inhibited brain acetylcholinesterase. Trimedoxime 31-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-151 15379785-6 2004 In addition, other structural analogues of trimedoxime were found to be efficacious in counteracting tabun-induced acetylcholinesterase inhibition although not as efficacious as trimedoxime itself. Trimedoxime 43-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 15207378-4 2004 The combination of differential metabolism of chiral organophosphorus (OP) pesticides and opposing stereoselectivity of inhibition of neuropathy target esterase (NTE) and acetylcholinesterase (AChE) can affect the value of the hen test, performed to OECD guidelines, in predicting the potential to cause organophosphate-induced delayed polyneuropathy (OPIDP) in humans. Organophosphates 304-319 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-197 15239242-8 2004 Both HD and IND could be diagnosed by rectal mucosal biopsies with AChE staining. indole 12-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 15239242-10 2004 CONCLUSIONS: We were able to obtain accurate diagnosis of childhood patients with HD and IND by rectal mucosal biopsy with AChE staining. indole 89-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 15311465-7 2004 quinquefasciatus was significantly more affected by dinotefuran than the susceptible strain (RR = 0.70), probably because the insensitive acetylcholinesterase is less efficient to degrade nicotinic substrates than normal acetylcholinesterase. dinotefuran 52-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 15311465-7 2004 quinquefasciatus was significantly more affected by dinotefuran than the susceptible strain (RR = 0.70), probably because the insensitive acetylcholinesterase is less efficient to degrade nicotinic substrates than normal acetylcholinesterase. dinotefuran 52-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 221-241 15296356-0 2004 [Galantamine, an acetylcholinesterase inhibitor with various actions]. Galantamine 1-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 15333628-8 2004 We conclude that short-term exposure to a single low dose of malathion causes prolonged modulation of the physiological function of the cutaneous vasculature and that this is, in part, through its action on acetylcholinesterase at both neuronal and nonneuronal sites. Malathion 61-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-227 15558381-1 2004 Donepezil, a primarily central acetylcholinesterase inhibitor, could potentiate learning in subjects with stroke by amplifying cholinergic input to the cerebral cortex from the nucleus basalis of Meynert. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 14985944-0 2004 Effect of organophosphorus hydrolysing enzymes on obidoxime-induced reactivation of organophosphate-inhibited human acetylcholinesterase. organophosphorus 10-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 14985944-0 2004 Effect of organophosphorus hydrolysing enzymes on obidoxime-induced reactivation of organophosphate-inhibited human acetylcholinesterase. Obidoxime Chloride 50-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 14985944-0 2004 Effect of organophosphorus hydrolysing enzymes on obidoxime-induced reactivation of organophosphate-inhibited human acetylcholinesterase. Organophosphates 84-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 14985944-1 2004 The reactivation of organophosphate (OP)-inhibited acetylcholinesterase (AChE) by oximes results inevitably in the formation of highly reactive phosphyloximes (POX), which may re-inhibit the enzyme. Organophosphates 20-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 14985944-1 2004 The reactivation of organophosphate (OP)-inhibited acetylcholinesterase (AChE) by oximes results inevitably in the formation of highly reactive phosphyloximes (POX), which may re-inhibit the enzyme. Organophosphates 20-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 14985944-1 2004 The reactivation of organophosphate (OP)-inhibited acetylcholinesterase (AChE) by oximes results inevitably in the formation of highly reactive phosphyloximes (POX), which may re-inhibit the enzyme. Oximes 82-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 14985944-1 2004 The reactivation of organophosphate (OP)-inhibited acetylcholinesterase (AChE) by oximes results inevitably in the formation of highly reactive phosphyloximes (POX), which may re-inhibit the enzyme. Oximes 82-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 14985944-3 2004 In this study the effect of organophosphorus hydrolase (OPH), organophosphorus acid anhydrolase (OPAA) and diisopropylfluorophosphatase (DFPase) on obidoxime-induced reactivation of human acetylcholinesterase (AChE) inhibited by different OPs was investigated. Obidoxime Chloride 148-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-208 14985944-3 2004 In this study the effect of organophosphorus hydrolase (OPH), organophosphorus acid anhydrolase (OPAA) and diisopropylfluorophosphatase (DFPase) on obidoxime-induced reactivation of human acetylcholinesterase (AChE) inhibited by different OPs was investigated. Obidoxime Chloride 148-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-214 14985944-4 2004 Reactivation of paraoxon-, sarin-, soman- and VX-inhibited AChE by obidoxime was impaired by POX-induced re-inhibition whereas no deviation of pseudo first-order kinetics was observed with tabun, cyclosarin and VR. Obidoxime Chloride 67-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 14985944-4 2004 Reactivation of paraoxon-, sarin-, soman- and VX-inhibited AChE by obidoxime was impaired by POX-induced re-inhibition whereas no deviation of pseudo first-order kinetics was observed with tabun, cyclosarin and VR. CHEMBL255237 93-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 14985944-4 2004 Reactivation of paraoxon-, sarin-, soman- and VX-inhibited AChE by obidoxime was impaired by POX-induced re-inhibition whereas no deviation of pseudo first-order kinetics was observed with tabun, cyclosarin and VR. cyclohexyl methylphosphonofluoridate 196-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 15386949-6 2004 CONCLUSION: The findings in the present study suggest that ADP can cause oxidative stress and free radical damage, and inhibit markedly erythrocyte acetylcholinesterase activity in ADPPs. Adenosine Diphosphate 59-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-168 15163283-3 2004 Based on limited open-labelled controlled studies of rivastigmine in VaD, this article aims to determine whether rivastigmine, a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), has any effects on the typical symptoms of subcortical VaD. Rivastigmine 113-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 15181367-0 2004 Evaluation of simplified kinetic analyses for measurement of brain acetylcholinesterase activity using N-[11C]Methylpiperidin-4-yl propionate and positron emission tomography. n-[11c]methylpiperidin-4-yl propionate 103-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 15118486-4 2004 Patients were assessed for clinical and immunologic features at baseline and after 1 month of treatment with Donepezil, an acetylcholinesterase inhibitor. Donepezil 109-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-143 15134651-6 2004 CD spectroscopy and calorimetry show the stability of these AChE model peptides is increased by addition of heparin, confirming binding to heparin, and the lack of significant enthalpy change indicates the binding is largely electrostatic in nature. Heparin 108-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 15134651-6 2004 CD spectroscopy and calorimetry show the stability of these AChE model peptides is increased by addition of heparin, confirming binding to heparin, and the lack of significant enthalpy change indicates the binding is largely electrostatic in nature. Heparin 139-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 15233279-1 2004 We have developed a radiolabeled lipophilic acetylcholine analogue, N-[11C]methylpiperidin-4-yl acetate ([11C]MP4A) to measure brain acetylcholinesterase (AChE) activity by positron emission tomography (PET) in vivo. Acetylcholine 44-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 15233279-1 2004 We have developed a radiolabeled lipophilic acetylcholine analogue, N-[11C]methylpiperidin-4-yl acetate ([11C]MP4A) to measure brain acetylcholinesterase (AChE) activity by positron emission tomography (PET) in vivo. N-methylpiperidin-4-yl acetate 68-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 17191882-6 2004 Furthermore, four xanthones among these xanthones had already been described as monoamine oxidase (MAO) inhibitors, making then dual AChE/MAO inhibitors of great interest. Xanthones 40-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 14647978-0 2004 Reactivation and aging kinetics of human acetylcholinesterase inhibited by organophosphonylcholines. organophosphonylcholines 75-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 15060281-3 2004 The AChE protein controls the termination of the stress-enhanced acetylcholine signaling, whereas the PON protein displays peroxidase-like activity, thus protecting blood proteins from oxidative stress damages. Acetylcholine 65-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 14647978-5 2004 Human AChE inhibited by MFPCh, MFP beta Ch or MFPhCh was extremely resistant towards reactivation by oximes. Oximes 101-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 14647978-8 2004 In conclusion, the unexpected results, i.e., high resistance of inhibited AChE towards oxime reactivation and aging, and much lower resistance towards spontaneous reactivation, calls for further experiments at a molecular level for a better understanding of the interactions among AChE, its inhibitors and reactivators. Oximes 87-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 15362815-10 2004 Carbamate poisoning was indicated on the basis of reactivation of brain AChE activity in two additional incidents. Carbamates 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 15066173-1 2004 The C-terminal t peptide (40 residues) of vertebrate acetylcholinesterase (AChE) T subunits possesses a series of seven conserved aromatic residues and forms an amphiphilic alpha-helix; it allows the formation of homo-oligomers (monomers, dimers and tetramers) and heteromeric associations with the anchoring proteins, ColQ and PRiMA, which contain a proline-rich motif (PRAD). Proline 351-358 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 15066173-1 2004 The C-terminal t peptide (40 residues) of vertebrate acetylcholinesterase (AChE) T subunits possesses a series of seven conserved aromatic residues and forms an amphiphilic alpha-helix; it allows the formation of homo-oligomers (monomers, dimers and tetramers) and heteromeric associations with the anchoring proteins, ColQ and PRiMA, which contain a proline-rich motif (PRAD). Proline 351-358 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 15161118-2 2004 Having obtained good results in a previous study comparing rivastigmine, an inhibitor of acetylcholinesterase (AChE) and butyrylcholine-sterase (BuChE), vs. aspirin, we aimed to compare the efficacy and tolerability of rivastigmine vs. aspirin plus nimodipine. Rivastigmine 59-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 15161118-2 2004 Having obtained good results in a previous study comparing rivastigmine, an inhibitor of acetylcholinesterase (AChE) and butyrylcholine-sterase (BuChE), vs. aspirin, we aimed to compare the efficacy and tolerability of rivastigmine vs. aspirin plus nimodipine. Rivastigmine 59-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 15034934-1 2004 Acetylcholinesterase mediates cell adhesion and neurite outgrowth through a site associated with the peripheral anionic site (PAS). Aminosalicylic Acid 126-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 15023064-0 2004 Is aromaticity essential for trapping the catalytic histidine 447 in human acetylcholinesterase? Histidine 52-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 15006409-0 2004 1H NMR relaxation investigation of acetylcholinesterase inhibitors from huperzine A and derivative. Hydrogen 0-2 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 15006409-0 2004 1H NMR relaxation investigation of acetylcholinesterase inhibitors from huperzine A and derivative. huperzine A 72-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 15023064-1 2004 Replacement of both the acyl pocket residue Phe295 as well as residue Phe338, adjacent to the catalytic His447 in human acetylcholinesterase (HuAChE), resulted in a 680-fold decline in catalytic activity due to conformational destabilization of the histidine side chain [Barak et al. Histidine 249-258 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 15006409-1 2004 The binding properties of huperzine A (1) with Torpediniforms Nacline acetylcholinesterase (TnAChE) were investigated by (1)H NMR methods. huperzine A 26-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 14702351-0 2004 C-terminal and heparin-binding domains of collagenic tail subunit are both essential for anchoring acetylcholinesterase at the synapse. Heparin 15-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 15006409-5 2004 The experiments give a possible method to use TnAChE to locate the new huperzine A derivatives as AChE inhibitors. huperzine A 71-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 15018574-0 2004 Activation of phosphorothionate pesticides based on a cytochrome P450 BM-3 (CYP102 A1) mutant for expanded neurotoxin detection in food using acetylcholinesterase biosensors. phosphorothiolate 14-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 15018574-1 2004 A novel enzymatic in vitro activation method for phosphorothionates has been developed to allow their detection with acetylcholinesterase (AChE) biosensors. phosphorothionates 49-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 15018574-1 2004 A novel enzymatic in vitro activation method for phosphorothionates has been developed to allow their detection with acetylcholinesterase (AChE) biosensors. phosphorothionates 49-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 15018574-9 2004 The application of the method to infant food in combination with a disposable AChE biosensor enabled detection of chlorpyrifos and parathion at concentrations down to 20 microg/kg within an overall assay time of 95 min. Chlorpyrifos 114-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 15018574-9 2004 The application of the method to infant food in combination with a disposable AChE biosensor enabled detection of chlorpyrifos and parathion at concentrations down to 20 microg/kg within an overall assay time of 95 min. Parathion 131-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 14766237-0 2004 Activation/deactivation of acetylcholinesterase by H2O2: more evidence for oxidative stress in vitiligo. Hydrogen Peroxide 51-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 14766237-5 2004 Using fluorescence immunohistochemistry we now show that epidermal H2O2 in vitiligo patients yields also almost absent epidermal acetylcholinesterase (AchE). Hydrogen Peroxide 67-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-149 14766237-5 2004 Using fluorescence immunohistochemistry we now show that epidermal H2O2 in vitiligo patients yields also almost absent epidermal acetylcholinesterase (AchE). Hydrogen Peroxide 67-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 14766237-6 2004 A kinetic analysis using pure recombinant human AchE revealed that low concentrations of H2O2 (10(-6)M) activate this enzyme by increasing the Vmax>2-fold, meanwhile high concentrations of H2O2 (10(-3)M) inhibit the enzyme with a significant decrease in Vmax. Hydrogen Peroxide 89-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 14766237-6 2004 A kinetic analysis using pure recombinant human AchE revealed that low concentrations of H2O2 (10(-6)M) activate this enzyme by increasing the Vmax>2-fold, meanwhile high concentrations of H2O2 (10(-3)M) inhibit the enzyme with a significant decrease in Vmax. Hydrogen Peroxide 192-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 14766237-8 2004 Molecular modelling based on the established 3D structure of human AchE supported that H2O2-mediated oxidation of Trp(432), Trp(435), and Met(436) moves and disorients the active site His(440) of the enzyme, leading to deactivation of the protein. Hydrogen Peroxide 87-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 14766237-8 2004 Molecular modelling based on the established 3D structure of human AchE supported that H2O2-mediated oxidation of Trp(432), Trp(435), and Met(436) moves and disorients the active site His(440) of the enzyme, leading to deactivation of the protein. Tryptophan 114-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 14766237-8 2004 Molecular modelling based on the established 3D structure of human AchE supported that H2O2-mediated oxidation of Trp(432), Trp(435), and Met(436) moves and disorients the active site His(440) of the enzyme, leading to deactivation of the protein. Tryptophan 124-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 14766237-9 2004 To our knowledge these results identified for the first time H2O2 regulation of AchE. Hydrogen Peroxide 61-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 14766237-10 2004 Moreover, it was shown that H2O2-mediated oxidation of AchE contributes significantly to the well-established oxidative stress in vitiligo. Hydrogen Peroxide 28-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 15023776-8 2004 Pyridostigmine bromide, an acetylcholinesterase inhibitor, produced effects similar to those of carbachol, which helps explain its clinical efficacy in a patient with active PV that was resistant to treatment with systemic glucocorticosteroids. Pyridostigmine Bromide 0-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 15095579-0 2004 [In vitro reactivation of acetylcholinesterase inhibition by O-isopropylmethylfluorophosphonate using the bisquarternary oxime, HS-6]. Sarin 61-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 15095579-0 2004 [In vitro reactivation of acetylcholinesterase inhibition by O-isopropylmethylfluorophosphonate using the bisquarternary oxime, HS-6]. bisquarternary oxime 106-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 15095579-0 2004 [In vitro reactivation of acetylcholinesterase inhibition by O-isopropylmethylfluorophosphonate using the bisquarternary oxime, HS-6]. HS 6 128-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 15095579-1 2004 The ability of the oxime HS-6 [1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium)-2-oxa-propane dichloride] to reactive in vitro the enzyme acetylcholinesterase inhibited by the nerve agent sarin [O-isopropylmethylfluorophosphonate] was evaluated. Oximes 19-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 15095579-1 2004 The ability of the oxime HS-6 [1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium)-2-oxa-propane dichloride] to reactive in vitro the enzyme acetylcholinesterase inhibited by the nerve agent sarin [O-isopropylmethylfluorophosphonate] was evaluated. hs-6 [1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium)-2-oxa-propane dichloride 25-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 15095579-3 2004 The oxime HS-6 was an effective reactivator of sarin-inhibited AChE. Oximes 4-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 15095579-3 2004 The oxime HS-6 was an effective reactivator of sarin-inhibited AChE. HS 6 10-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 15009674-7 2004 The effect of Abeta1-42 on AChE was blocked by inhibitors of alpha7 nicotinic acetylcholine receptors (alpha7 nAChRs) as well as by inhibitors of L- or N-type voltage-dependent calcium channels (VDCCs), whereas agonists of alpha7 nAChRs (choline, nicotine) increased the level of AChE. nachrs 110-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 15009674-7 2004 The effect of Abeta1-42 on AChE was blocked by inhibitors of alpha7 nicotinic acetylcholine receptors (alpha7 nAChRs) as well as by inhibitors of L- or N-type voltage-dependent calcium channels (VDCCs), whereas agonists of alpha7 nAChRs (choline, nicotine) increased the level of AChE. Choline 84-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 15009674-7 2004 The effect of Abeta1-42 on AChE was blocked by inhibitors of alpha7 nicotinic acetylcholine receptors (alpha7 nAChRs) as well as by inhibitors of L- or N-type voltage-dependent calcium channels (VDCCs), whereas agonists of alpha7 nAChRs (choline, nicotine) increased the level of AChE. Nicotine 247-255 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 15038335-2 2004 Myoclonus and delirium improved dramatically with the intravenous injection of the acetylcholinesterase inhibitor physostigmine, and this improvement was maintained during the administration of donepezil, an oral medication with similar pharmacodynamic properties. Physostigmine 114-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 15019964-2 2004 The major mechanism of acute toxic action is the inhibition of acetylcholinesterase (AChE), which is responsible for the degradation of the neurotransmitter acetylcholine. Acetylcholine 63-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 15114506-0 2004 Acetylcholinesterase enzyme inhibitory effects of amaryllidaceae alkaloids. Amaryllidaceae Alkaloids 50-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 15114506-1 2004 Twenty-three Amaryllidaceae alkaloids having several different ring types were evaluated for their acetylcholinesterase enzyme (AChE) inhibitory activity. Amaryllidaceae Alkaloids 13-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 15114506-2 2004 The alkaloid 1- O-acetyllycorine (IC50 : 0.96 +/- 0.04) showed significant AChE inhibitory activity. 1- o-acetyllycorine 13-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 14757314-3 2004 It was found that tellimagrandin I not only inhibited the hemoglobin synthesis in butyric acid (BA)- and hemin-induced K562 cells with IC50 of 3 and 40microM, respectively, but also inhibited other erythroid differentiation marker including acetylcholinesterase (AChE) and glycophorin A (GPA) in BA-induced K562 cells. tellimagrandin I 18-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 241-261 14757314-3 2004 It was found that tellimagrandin I not only inhibited the hemoglobin synthesis in butyric acid (BA)- and hemin-induced K562 cells with IC50 of 3 and 40microM, respectively, but also inhibited other erythroid differentiation marker including acetylcholinesterase (AChE) and glycophorin A (GPA) in BA-induced K562 cells. tellimagrandin I 18-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 263-267 15241943-1 2004 The power of chosen carbamates and hydrazinium derivatives (carbazates) to inhibit the hydrolysis of acetylthiocholine by butyrylcholinesterase or acetylcholinesterase was tested. Carbamates 20-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 15241943-1 2004 The power of chosen carbamates and hydrazinium derivatives (carbazates) to inhibit the hydrolysis of acetylthiocholine by butyrylcholinesterase or acetylcholinesterase was tested. hydrazinium 35-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 15241943-1 2004 The power of chosen carbamates and hydrazinium derivatives (carbazates) to inhibit the hydrolysis of acetylthiocholine by butyrylcholinesterase or acetylcholinesterase was tested. Acetylthiocholine 101-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 14709383-1 2004 In this study, acetylcholinesterase (AChE) and choline oxidase (ChO) were co-immobilized on poly(2-hydroxyethyl methacrylate) (pHEMA) membranes to construct a biosensor for the detection of anti-cholinesterase compounds. Polyhydroxyethyl Methacrylate 92-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 14709383-1 2004 In this study, acetylcholinesterase (AChE) and choline oxidase (ChO) were co-immobilized on poly(2-hydroxyethyl methacrylate) (pHEMA) membranes to construct a biosensor for the detection of anti-cholinesterase compounds. Polyhydroxyethyl Methacrylate 92-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 15223749-7 2004 We report a detailed thiocholine protocol that is a modification of the Koelle-Friedenwald method to amplify the AChE signal in brain sections previously processed for autoradiography. Thiocholine 21-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 14748409-1 2004 The ability of a new bisquaternary oxime, K027 (1-[4-hydroxyiminomethylpyridinium]-3-[carbamoylpyridinium] propane dibromide), to reactivate the enzyme acetylcholinesterase (AChE) inhibited by the nerve agents Tabun, sarin and VX was evaluated. bisquaternary oxime 21-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 14748409-1 2004 The ability of a new bisquaternary oxime, K027 (1-[4-hydroxyiminomethylpyridinium]-3-[carbamoylpyridinium] propane dibromide), to reactivate the enzyme acetylcholinesterase (AChE) inhibited by the nerve agents Tabun, sarin and VX was evaluated. bisquaternary oxime 21-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 14748409-1 2004 The ability of a new bisquaternary oxime, K027 (1-[4-hydroxyiminomethylpyridinium]-3-[carbamoylpyridinium] propane dibromide), to reactivate the enzyme acetylcholinesterase (AChE) inhibited by the nerve agents Tabun, sarin and VX was evaluated. Atracurium besylate 42-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 14748409-1 2004 The ability of a new bisquaternary oxime, K027 (1-[4-hydroxyiminomethylpyridinium]-3-[carbamoylpyridinium] propane dibromide), to reactivate the enzyme acetylcholinesterase (AChE) inhibited by the nerve agents Tabun, sarin and VX was evaluated. Atracurium besylate 42-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 14748409-1 2004 The ability of a new bisquaternary oxime, K027 (1-[4-hydroxyiminomethylpyridinium]-3-[carbamoylpyridinium] propane dibromide), to reactivate the enzyme acetylcholinesterase (AChE) inhibited by the nerve agents Tabun, sarin and VX was evaluated. 1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide 48-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 14748409-1 2004 The ability of a new bisquaternary oxime, K027 (1-[4-hydroxyiminomethylpyridinium]-3-[carbamoylpyridinium] propane dibromide), to reactivate the enzyme acetylcholinesterase (AChE) inhibited by the nerve agents Tabun, sarin and VX was evaluated. 1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide 48-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 15568733-0 2004 1,3-Bis(2-hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents. 1,3-bis(2-hydroxyiminomethylpyridinium)propane 0-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 15568733-1 2004 The oxime K005 [1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX was tested. Oximes 4-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 15568733-1 2004 The oxime K005 [1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX was tested. Oximes 4-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 15568733-1 2004 The oxime K005 [1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX was tested. Betaxolol 10-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 15568733-1 2004 The oxime K005 [1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX was tested. Betaxolol 10-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 15568733-1 2004 The oxime K005 [1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX was tested. 1,3-bis(2-hydroxyiminomethylpyridinium)propane 16-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 15568733-1 2004 The oxime K005 [1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX was tested. 1,3-bis(2-hydroxyiminomethylpyridinium)propane 16-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 15568733-1 2004 The oxime K005 [1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX was tested. cyclohexyl methylphosphonofluoridate 151-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 15568733-1 2004 The oxime K005 [1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX was tested. cyclohexyl methylphosphonofluoridate 151-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 15568733-1 2004 The oxime K005 [1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX was tested. VX 166-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 15568733-1 2004 The oxime K005 [1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX was tested. VX 166-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 15065394-1 2004 The therapeutic efficacy of selected reactivators of acetylcholinesterase (obidoxime, oxime HI-6, trimedoxime) against acute tabun poisoning in dependence on their dose was examined in experiments on male mice. Obidoxime Chloride 75-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 15065394-1 2004 The therapeutic efficacy of selected reactivators of acetylcholinesterase (obidoxime, oxime HI-6, trimedoxime) against acute tabun poisoning in dependence on their dose was examined in experiments on male mice. oxime hi-6 86-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 14754384-11 2004 Tacrine, the first acetylcholinesterase inhibitor who became available in 1993 as a treatment for AD, does not play an essential role anymore besides his historical value, because of its hepatotoxicity. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 15544502-2 2004 Most of AD treatments have been focused on the inhibition of acetylcholinesterase (AChE) in order to raise the levels of its substrate, i.e. the neurotransmitter acetylcholine (ACh), to augment cognitive functions of affected patients. Acetylcholine 61-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 15544502-2 2004 Most of AD treatments have been focused on the inhibition of acetylcholinesterase (AChE) in order to raise the levels of its substrate, i.e. the neurotransmitter acetylcholine (ACh), to augment cognitive functions of affected patients. Acetylcholine 83-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 15544502-3 2004 Effectiveness in AChE inhibition and side-effect issues of clinical (tacrine, donepezil, galanthamine and rivastigmine) as well as of novel inhibitors is reviewed here. Tacrine 69-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 15544502-3 2004 Effectiveness in AChE inhibition and side-effect issues of clinical (tacrine, donepezil, galanthamine and rivastigmine) as well as of novel inhibitors is reviewed here. Donepezil 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 15544502-3 2004 Effectiveness in AChE inhibition and side-effect issues of clinical (tacrine, donepezil, galanthamine and rivastigmine) as well as of novel inhibitors is reviewed here. Galantamine 89-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 15544502-3 2004 Effectiveness in AChE inhibition and side-effect issues of clinical (tacrine, donepezil, galanthamine and rivastigmine) as well as of novel inhibitors is reviewed here. Rivastigmine 106-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 15544502-4 2004 Novel design methods for the inhibition of AChE include the use of in silico tools to predict the interactions between AChE and the desired compound, both at the active site of the enzyme, responsible of hydrolysing ACh and with the peripheral anionic site (PAS), which has been described as a promoting agent of the amyloid beta-peptide (A beta) aggregation present in the senile plaques of the brain of AD individuals. Acetylcholine 43-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 15544504-4 2004 In this review we will describe the development of dimeric AChE inhibitors, from the early observations of high inhibition potency by bis-quaternary inhibitors, to the structure-based design of dimers based on tacrine, huperzine A, galanthamine, and polyamines. huperzine A 219-230 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 15544504-4 2004 In this review we will describe the development of dimeric AChE inhibitors, from the early observations of high inhibition potency by bis-quaternary inhibitors, to the structure-based design of dimers based on tacrine, huperzine A, galanthamine, and polyamines. Galantamine 232-244 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 15544504-4 2004 In this review we will describe the development of dimeric AChE inhibitors, from the early observations of high inhibition potency by bis-quaternary inhibitors, to the structure-based design of dimers based on tacrine, huperzine A, galanthamine, and polyamines. Polyamines 250-260 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 15544506-8 2004 More recently, a novel drug--TV3326--was designed, based upon two pharmacophores: the carbamate moiety from rivastigmine, an AChE inhibitor; and the propargyl group from rasagiline, a MAO inhibitor. (N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate 29-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 15544507-2 2004 Thus, it is not surprising that the first therapeutic target that has demonstrated therapeutic efficacy on cognition, behaviour and functional daily activities has been the inhibitors of acetylcholinesterase (AChE), i.e. tacrine, donepezil, rivastigmine and galanthamine. Tacrine 221-228 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-207 15544507-2 2004 Thus, it is not surprising that the first therapeutic target that has demonstrated therapeutic efficacy on cognition, behaviour and functional daily activities has been the inhibitors of acetylcholinesterase (AChE), i.e. tacrine, donepezil, rivastigmine and galanthamine. Tacrine 221-228 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-213 15544507-2 2004 Thus, it is not surprising that the first therapeutic target that has demonstrated therapeutic efficacy on cognition, behaviour and functional daily activities has been the inhibitors of acetylcholinesterase (AChE), i.e. tacrine, donepezil, rivastigmine and galanthamine. Donepezil 230-239 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-213 15544507-2 2004 Thus, it is not surprising that the first therapeutic target that has demonstrated therapeutic efficacy on cognition, behaviour and functional daily activities has been the inhibitors of acetylcholinesterase (AChE), i.e. tacrine, donepezil, rivastigmine and galanthamine. Rivastigmine 241-253 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-207 15544507-2 2004 Thus, it is not surprising that the first therapeutic target that has demonstrated therapeutic efficacy on cognition, behaviour and functional daily activities has been the inhibitors of acetylcholinesterase (AChE), i.e. tacrine, donepezil, rivastigmine and galanthamine. Rivastigmine 241-253 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-213 15544507-2 2004 Thus, it is not surprising that the first therapeutic target that has demonstrated therapeutic efficacy on cognition, behaviour and functional daily activities has been the inhibitors of acetylcholinesterase (AChE), i.e. tacrine, donepezil, rivastigmine and galanthamine. Galantamine 258-270 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-207 15544507-2 2004 Thus, it is not surprising that the first therapeutic target that has demonstrated therapeutic efficacy on cognition, behaviour and functional daily activities has been the inhibitors of acetylcholinesterase (AChE), i.e. tacrine, donepezil, rivastigmine and galanthamine. Galantamine 258-270 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-213 15544507-4 2004 For instance, rivastigmine is a dual inhibitor of AChE and butyrylcholinesterase (BuChE), and galanthamine is a mild inhibitor of AChE and an allosteric potentiating ligand of neuronal nicotinic receptors for acetylcholine (nAChRs). Rivastigmine 14-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 15544507-4 2004 For instance, rivastigmine is a dual inhibitor of AChE and butyrylcholinesterase (BuChE), and galanthamine is a mild inhibitor of AChE and an allosteric potentiating ligand of neuronal nicotinic receptors for acetylcholine (nAChRs). Galantamine 94-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 15544507-6 2004 In this frame, we have been synthesizing new tacrine derivatives that keep their ability to inhibit AChE but that interfere with neuronal calcium overloading and prevent apoptosis. Tacrine 45-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 15132713-3 2004 The common mechanism of action underlying this class of agents is an increase in available acetylcholine through inhibition of the catabolic enzyme, acetylcholinesterase. Acetylcholine 91-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-169 15132713-4 2004 There is substantial evidence that the cholinesterase inhibitors, including donepezil, galantamine and rivastigmine, decrease acetylcholinesterase activity in a number of brain regions in patients with Alzheimer"s disease. Donepezil 76-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 15132713-4 2004 There is substantial evidence that the cholinesterase inhibitors, including donepezil, galantamine and rivastigmine, decrease acetylcholinesterase activity in a number of brain regions in patients with Alzheimer"s disease. Galantamine 87-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 15132713-4 2004 There is substantial evidence that the cholinesterase inhibitors, including donepezil, galantamine and rivastigmine, decrease acetylcholinesterase activity in a number of brain regions in patients with Alzheimer"s disease. Rivastigmine 103-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 14686917-1 2004 Acetylcholinesterase subunits of type T (AChET) possess an alternatively spliced C-terminal peptide (t peptide) which endows them with amphiphilic properties, the capacity to form various homo-oligomers and to associate, as a tetramer, with anchoring proteins containing a proline rich attachment domain (PRAD). Proline 273-280 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 15101572-1 2004 We present the case of a patient with Huntington"s disease and psychosis, whose motor and psychiatric symptoms improved after administration of galantamine, an acetylcholinesterase inhibitor. Galantamine 144-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-180 14964575-4 2004 In contrast, only one acetylcholinesterase inhibitor, donepezil has been proven effective and used for patients with mild or moderate Alzheimer"s disease in Japan. Donepezil 54-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 15161118-6 2004 The benefits observed with rivastigmine may reflect its inhibitory effects on AChE and BuChE, and the drug"s affinity for frontal brain areas. Rivastigmine 27-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 14969339-1 2004 In the course of finding Korean natural products with acetylcholinesterase (AChE) inhibitory activity, we found that a methanolic extract of the twigs of Vaccinium oldhami significantly inhibited AChE. methanolic 119-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 14969339-1 2004 In the course of finding Korean natural products with acetylcholinesterase (AChE) inhibitory activity, we found that a methanolic extract of the twigs of Vaccinium oldhami significantly inhibited AChE. methanolic 119-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 14969339-1 2004 In the course of finding Korean natural products with acetylcholinesterase (AChE) inhibitory activity, we found that a methanolic extract of the twigs of Vaccinium oldhami significantly inhibited AChE. methanolic 119-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 196-200 15508279-1 2004 Enzyme electrodes for the determination of organophosphate pesticides were developed by using acetylcholinesterase (AChE) in combination with a pH electrode. Organophosphates 43-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 15508279-1 2004 Enzyme electrodes for the determination of organophosphate pesticides were developed by using acetylcholinesterase (AChE) in combination with a pH electrode. Organophosphates 43-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 15222774-4 2004 Post-hoc analyses of rivastigmine and galantamine in patients with more advanced Alzheimer"s disease have supported the hypothesis that acetylcholinesterase inhibitors are likely be efficacious in this subgroup. Rivastigmine 21-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 15222774-4 2004 Post-hoc analyses of rivastigmine and galantamine in patients with more advanced Alzheimer"s disease have supported the hypothesis that acetylcholinesterase inhibitors are likely be efficacious in this subgroup. Galantamine 38-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 15134572-1 2004 Several cholinesterase (ChE) inhibitors have been labeled with carbon-11 for visualizing binding sites on acetylcholinesterase (AChE) by positron emission tomography (PET). Carbon-11 63-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 15134572-1 2004 Several cholinesterase (ChE) inhibitors have been labeled with carbon-11 for visualizing binding sites on acetylcholinesterase (AChE) by positron emission tomography (PET). Carbon-11 63-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 15134572-3 2004 PET studies with [(11)C]physostigmine and [(11)C]CP-126,998 in the brain of healthy subjects have shown a radioactivity distribution corresponding to the regional distribution of AChE activity measured in postmortem human brains. Carbon-11 17-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 179-183 15134572-3 2004 PET studies with [(11)C]physostigmine and [(11)C]CP-126,998 in the brain of healthy subjects have shown a radioactivity distribution corresponding to the regional distribution of AChE activity measured in postmortem human brains. Physostigmine 24-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 179-183 15134572-3 2004 PET studies with [(11)C]physostigmine and [(11)C]CP-126,998 in the brain of healthy subjects have shown a radioactivity distribution corresponding to the regional distribution of AChE activity measured in postmortem human brains. cp-126 49-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 179-183 15134572-5 2004 An alternative approach to map AChE is the use of acetylcholine analogue substrates. Acetylcholine 50-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 15134572-6 2004 We have developed N-methylpiperidinyl esters labeled with carbon-11 for quantitative measurement of AChE activity. n-methylpiperidinyl esters 18-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 15134572-6 2004 We have developed N-methylpiperidinyl esters labeled with carbon-11 for quantitative measurement of AChE activity. Carbon-11 58-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 15134572-8 2004 Both [(11)C]MP4A- and [(11)C]MP4P-PET have demonstrated not only the reduction of AChE activity in the cerebral cortex of patients with Alzheimer"s disease (AD) but also the inhibitory effects of donepezil and rivastigmine on AChE activity in the brain of AD patients. Donepezil 196-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-230 14560059-1 2004 In the present study, the socioeconomic impact of the use of the acetylcholinesterase inhibitor donepezil in patients with mild to moderate Alzheimer"s disease (AD) living in France was examined. Donepezil 96-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 14725492-3 2004 The mechanism of action of huperzine A is suggested to be facilitated through the slow reversible inhibition of acetylcholinesterase. huperzine A 27-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 15554751-1 2004 OBJECTIVE: This preliminary open-label study aims to investigate the effects of rivastigmine, an inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), in 20 patients diagnosed with frontotemporal dementia (FTD). Rivastigmine 80-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 15554751-1 2004 OBJECTIVE: This preliminary open-label study aims to investigate the effects of rivastigmine, an inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), in 20 patients diagnosed with frontotemporal dementia (FTD). Rivastigmine 80-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 15507109-3 2004 Only very recently it has been recognized that acetylcholinesterase, but not cholineacetyltransferase, activity is regulated by hydrogen peroxide. Hydrogen Peroxide 128-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 14654102-1 2004 Galantamine is currently used to treat Alzheimer"s disease patients; it behaves as a mild blocker of acetylcholinesterase (AChE) and has an allosteric modulating action on nicotinic acetylcholine receptors (nAChRs). Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 14741650-3 2004 Measurements were performed in normal controls and in patients with mild to moderate AD with positron emission tomography (PET) and C-11-labeled N-methyl-4-piperidyl-acetate (MP4A) which is a specific substrate of AChE. N-methyl-4-piperidyl acetate 145-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-218 14741650-3 2004 Measurements were performed in normal controls and in patients with mild to moderate AD with positron emission tomography (PET) and C-11-labeled N-methyl-4-piperidyl-acetate (MP4A) which is a specific substrate of AChE. mp4a 175-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-218 14654102-1 2004 Galantamine is currently used to treat Alzheimer"s disease patients; it behaves as a mild blocker of acetylcholinesterase (AChE) and has an allosteric modulating action on nicotinic acetylcholine receptors (nAChRs). Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 14602572-5 2003 The authors demonstrated both sympathetic and parasympathetic neurons in the PCG by labeling of acetylcholinesterase and tryosine hydroxlyase, and noted that infection was limited mainly or entirely to parasympathetic neurons. pcg 77-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 14573772-8 2003 Unlike galantamine, the acetylcholinesterase inhibitors rivastigmine and donepezil did not potentiate nAChR-mediated responses, whereas donepezil was a reasonably potent inhibitor of nicotine- and KCl-evoked increases in Ca2+. Rivastigmine 56-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 14674691-0 2003 Inactivation of acetylcholinesterase by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride. MPTP hydrochloride 40-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 14674691-1 2003 The neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been shown to reversibly inhibit the activity of acetylcholinesterase. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 18-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-143 14674691-1 2003 The neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been shown to reversibly inhibit the activity of acetylcholinesterase. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 64-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-143 14674691-7 2003 The dilution assays indicate that MPTP is a reversible inhibitor for AChE. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 34-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 14674691-8 2003 These data suggest that once MPTP enters the basal ganglia of the brain, it can inactivate the acetylcholinesterase enzyme and thereby increase the acetylcholine level in the basal ganglia of brain, leading to potential cell dysfunction. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 29-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 14674691-9 2003 It appears that the nigrostriatal toxicity by MPTP leading to Parkinson"s disease-like syndrome may, in part, be mediated via the acetylcholinesterase inactivation. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 46-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 14561111-1 2003 Our goal in this study was to determine whether donepezil, an acetylcholinesterase inhibitor, would improve cognitive functioning in 19 subjects with Down syndrome and no dementia. Donepezil 48-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 12955395-1 2003 The interaction between human serum albumin (HSA) and the acetylcholinesterase inhibitor donepezil, has been studied by means of capillary electrophoresis frontal analysis (CE/FA) and circular dichroism. Donepezil 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 14646612-1 2003 We aimed to determine whether the cholinesterase inhibitor rivastigmine, an inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), would improve quality of life and cognitive function in 16 clinically stable subjects affected by schizophrenia in the residual phase. Rivastigmine 59-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 15143516-2 2003 The activity of acetylcholinesterase in suspension of cells compounds is 9.8 +/- 0.2 mumol of tiocholinbromide/mg protein/hour and is reduced under influence of exogenous ATP, NO2-, H2O2 and Triton X-100. tiocholinbromide 94-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 15143516-2 2003 The activity of acetylcholinesterase in suspension of cells compounds is 9.8 +/- 0.2 mumol of tiocholinbromide/mg protein/hour and is reduced under influence of exogenous ATP, NO2-, H2O2 and Triton X-100. Adenosine Triphosphate 171-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 15143516-2 2003 The activity of acetylcholinesterase in suspension of cells compounds is 9.8 +/- 0.2 mumol of tiocholinbromide/mg protein/hour and is reduced under influence of exogenous ATP, NO2-, H2O2 and Triton X-100. Nitrogen Dioxide 176-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 15143516-2 2003 The activity of acetylcholinesterase in suspension of cells compounds is 9.8 +/- 0.2 mumol of tiocholinbromide/mg protein/hour and is reduced under influence of exogenous ATP, NO2-, H2O2 and Triton X-100. Hydrogen Peroxide 182-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 15143516-2 2003 The activity of acetylcholinesterase in suspension of cells compounds is 9.8 +/- 0.2 mumol of tiocholinbromide/mg protein/hour and is reduced under influence of exogenous ATP, NO2-, H2O2 and Triton X-100. Octoxynol 191-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 14627729-1 2003 A combined molecular dynamics simulation and multiple ligand docking approach is applied to study the roles of the anionic subsite residues (W86, E202, Y337) in the binding of acetylcholine (ACh) to acetylcholinesterase (AChE). Acetylcholine 176-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 221-225 14627729-1 2003 A combined molecular dynamics simulation and multiple ligand docking approach is applied to study the roles of the anionic subsite residues (W86, E202, Y337) in the binding of acetylcholine (ACh) to acetylcholinesterase (AChE). Acetylcholine 191-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 221-225 14627729-4 2003 Docking energies of ACh to mutant AChE show a more pronounced effect because of size/shape complementarity. Acetylcholine 20-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 12963741-6 2003 The cAMP-responsive element mutation on human AChE promoter blocked the muscle-induced AChE transcriptional activity in cultured NG108-15 cells either in co-culturing with myotube or in applying muscle extract. Cyclic AMP 4-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 12963741-6 2003 The cAMP-responsive element mutation on human AChE promoter blocked the muscle-induced AChE transcriptional activity in cultured NG108-15 cells either in co-culturing with myotube or in applying muscle extract. Cyclic AMP 4-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 14594748-1 2003 OBJECTIVE: The authors examined the effect of the acetylcholinesterase inhibitor donepezil on magnetic resonance markers of neurodegeneration in Alzheimer"s disease. Donepezil 81-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 14639745-0 2003 Synthesis, biological activity, and docking studies of new acetylcholinesterase inhibitors of the bispyridinium type. bispyridinium 98-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 14639745-1 2003 A novel series of acetylcholinesterase (AChE) inhibitors of the bispyridinium type was synthesized and the inhibitory activity against AChE and butyrylcholinesterase (BChE) measured. bispyridinium 64-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 14639745-1 2003 A novel series of acetylcholinesterase (AChE) inhibitors of the bispyridinium type was synthesized and the inhibitory activity against AChE and butyrylcholinesterase (BChE) measured. bispyridinium 64-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 14639745-2 2003 In essence, the substitution pattern influenced the inhibitory potency against AChE, where the most active bispyridiniumoxime (TMB-4) was bisbenzyl substituted followed by monobenzyl substituted, bismethyl substituted, and unsubstituted derivatives of TMB-4. bispyridiniumoxime 107-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 14639745-2 2003 In essence, the substitution pattern influenced the inhibitory potency against AChE, where the most active bispyridiniumoxime (TMB-4) was bisbenzyl substituted followed by monobenzyl substituted, bismethyl substituted, and unsubstituted derivatives of TMB-4. Trimedoxime 127-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 14639745-2 2003 In essence, the substitution pattern influenced the inhibitory potency against AChE, where the most active bispyridiniumoxime (TMB-4) was bisbenzyl substituted followed by monobenzyl substituted, bismethyl substituted, and unsubstituted derivatives of TMB-4. bisbenzyl 138-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 14639745-2 2003 In essence, the substitution pattern influenced the inhibitory potency against AChE, where the most active bispyridiniumoxime (TMB-4) was bisbenzyl substituted followed by monobenzyl substituted, bismethyl substituted, and unsubstituted derivatives of TMB-4. monobenzyl 172-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 14639745-2 2003 In essence, the substitution pattern influenced the inhibitory potency against AChE, where the most active bispyridiniumoxime (TMB-4) was bisbenzyl substituted followed by monobenzyl substituted, bismethyl substituted, and unsubstituted derivatives of TMB-4. Trimedoxime 252-257 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 14622273-1 2003 E2020 (R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methyl)piperidine hydrochloride is a piperidine-based acetylcholinesterase (AChE) inhibitor that was approved for the treatment of Alzheimer"s disease in the United States. (r,s)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methyl)piperidine hydrochloride 6-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 14622273-1 2003 E2020 (R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methyl)piperidine hydrochloride is a piperidine-based acetylcholinesterase (AChE) inhibitor that was approved for the treatment of Alzheimer"s disease in the United States. piperidine 62-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 14622273-9 2003 The observation that the KI value for mutant AChE in which Ala replaced Trp286 is similar to that for wild-type BChE, further confirms our hypothesis. Alanine 59-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 14635269-2 2003 In addition, MCP is a reversible inhibitor of cholinesterases from the human central nervous system and blood, and may have a red blood cell (RBC) acetylcholinesterase (AChE) protective effect against inhibition by organophosphates. Organophosphates 215-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 14738173-5 2003 Acetylcholinesterase (a possible detoxifier of cocaine) abolished the effect of cocaine on prostacyclin production. Cocaine 47-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 14505667-1 2003 Synthesis of a new asymmetric bisquaternary reactivator of tabun-inhibited acetylcholinesterase-1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane dibromide is described. 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane 96-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 14535761-0 2003 Sieboldine A, a novel tetracyclic alkaloid from Lycopodium sieboldii, inhibiting acetylcholinesterase. sieboldine A 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 14535761-0 2003 Sieboldine A, a novel tetracyclic alkaloid from Lycopodium sieboldii, inhibiting acetylcholinesterase. tetracyclic alkaloid 22-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 14535761-3 2003 Sieboldine A (1) exhibited a potent inhibitory activity against acetylcholinesterase and modest cytotoxicity. sieboldine A 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 12851386-2 2003 AChE is inactivated by organophosphates as they pass through the P-site and phosphorylate the catalytic serine in the A-site. Organophosphates 23-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 12851386-2 2003 AChE is inactivated by organophosphates as they pass through the P-site and phosphorylate the catalytic serine in the A-site. Serine 104-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 12851386-4 2003 To accelerate the process of identifying cyclic compounds with high affinity for the AChE P-site, we introduced a cysteine residue near the rim of the P-site by site-specific mutagenesis to generate recombinant human H287C AChE. Cysteine 114-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 12851386-4 2003 To accelerate the process of identifying cyclic compounds with high affinity for the AChE P-site, we introduced a cysteine residue near the rim of the P-site by site-specific mutagenesis to generate recombinant human H287C AChE. Cysteine 114-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 223-227 12851386-6 2003 The advantages of this tethering were demonstrated with H287C AChE modified with six compounds, consisting of cationic trialkylammonium, acridinium, and tacrine ligands with tethers of varying length. trialkylammonium 119-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 12851386-6 2003 The advantages of this tethering were demonstrated with H287C AChE modified with six compounds, consisting of cationic trialkylammonium, acridinium, and tacrine ligands with tethers of varying length. acridinium I 137-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 12851386-6 2003 The advantages of this tethering were demonstrated with H287C AChE modified with six compounds, consisting of cationic trialkylammonium, acridinium, and tacrine ligands with tethers of varying length. Tacrine 153-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 13129577-1 2003 Alzheimer"s disease (AD) has been treated with acetylcholinesterase (AChE) inhibitors such as donepezil. Donepezil 94-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 13129577-1 2003 Alzheimer"s disease (AD) has been treated with acetylcholinesterase (AChE) inhibitors such as donepezil. Donepezil 94-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 14626722-0 2003 The clinical and electrophysiological features of a delayed polyneuropathy developing subsequently after acute organophosphate poisoning and it"s correlation with the serum acetylcholinesterase. Organophosphates 111-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-193 14738173-5 2003 Acetylcholinesterase (a possible detoxifier of cocaine) abolished the effect of cocaine on prostacyclin production. Cocaine 80-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 14738173-5 2003 Acetylcholinesterase (a possible detoxifier of cocaine) abolished the effect of cocaine on prostacyclin production. Epoprostenol 91-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 12840078-1 2003 Application of the acetylcholinesterase inhibitor physostigmine to conventional hippocampal slices caused a significant reduction of field excitatory postsynaptic potentials (EPSPs) elicited by single pulse stimulation to the medial perforant path. Physostigmine 50-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 14607022-1 2003 A novel series of bispyridinium-type acetylcholinesterase (AChE) inhibitors derived from obidoxime, being active in the lower micromolar range, has been reported recently. Obidoxime Chloride 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 14560923-0 2003 Inhibitory effect of trans-N-p-coumaroyl tryamine from the twigs of Celtis chinensis on the acetylcholinesterase. trans-n-p-coumaroyl tryamine 21-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 12962511-7 2003 A second monoclonal antibody raised against the fibrillogenic AChE(586-599) fragment recognizes not only beta-sheet amyloid aggregates but also SDS-resistant protofibrillar oligomers. Sodium Dodecyl Sulfate 144-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 12956931-5 2003 No change in the cytotoxicity of A beta 25-35 was observed when the increased AChE activities were effectively inhibited by huperzine A throughout the 48-h exposure period. huperzine A 124-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 12956931-6 2003 CONCLUSION: Although A beta 25-35 can induce apoptosis in SC42 cells and simultaneously increase AChE activity, the capacity of AChE to hydrolyze acetylcholine is not involved in this apoptosis model. Acetylcholine 146-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 14599456-8 2003 In conclusion, the main effects detected for tribromophenol were the induction of neuroblastoma cell differentiation, as expressed by the inhibition of cell growth and the increase in acetylcholinesterase activity with a critical cell concentration of 0.1 microM. 2,4,6-tribromophenol 45-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-204 14569643-2 2003 This study aimed to determine whether rivastigmine, a dual inhibitor of acetylcholinesterase (AChE) and butyryl-cholinesterase (BuChE), has any effects on the typical symptoms of subcortical VaD. Rivastigmine 38-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 14560923-1 2003 The methanolic extract of the twigs of Celtis chinensis was found to show inhibitory activity on acetylcholinesterase (AChE), an enzyme that plays a role in the metabolic hydrolysis of ACh. methanolic 4-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 14560923-1 2003 The methanolic extract of the twigs of Celtis chinensis was found to show inhibitory activity on acetylcholinesterase (AChE), an enzyme that plays a role in the metabolic hydrolysis of ACh. methanolic 4-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 14560923-1 2003 The methanolic extract of the twigs of Celtis chinensis was found to show inhibitory activity on acetylcholinesterase (AChE), an enzyme that plays a role in the metabolic hydrolysis of ACh. Acetylcholine 119-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 14560923-2 2003 Bioassay-guided fractionation of the methanolic extract resulted in the isolation of N-p-coumaroyl tyramine, as an inhibitor on AChE. methanolic 37-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 14560923-2 2003 Bioassay-guided fractionation of the methanolic extract resulted in the isolation of N-p-coumaroyl tyramine, as an inhibitor on AChE. N-coumaroyltyramine 85-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 14611850-1 2003 Cage amines 1-4 are potent peripheral anionic site-bound reversible inhibitors of both acetylcholinesterase and butyrylcholinesterase. Amines 5-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 14560923-3 2003 This compound inhibited AChE activity in a dose-dependent manner, and the IC50 value of trans-N-p-coumaroyl tyramine was 34.5 microg/mL (122 microM). trans-N-p-coumaroyl tyramine 88-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 14611850-3 2003 For both enzymes, the -log K(i) values linearly correlate with the difference of substituted phenyl radius of cage amines (-log K(i)=5.4+3.4Deltagamma for acetylcholinesterase, -log K(i)=5.9+3.2Deltagamma for butyrylcholinesterase). Amines 115-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-175 13679187-0 2003 Design, synthesis and biological evaluation of ambenonium derivatives as AChE inhibitors. Ambenonium Chloride 47-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 13679187-1 2003 Ambenonium (1), an old AChE inhibitor, is endowed with an outstanding affinity and a peculiar mechanism of action that, taken together, make it a very promising pharmacological tool for the treatment of Alzheimer"s disease (AD). ambenonium (1) 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 12811800-1 2003 It has been hypothesized that acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) are coregulators of the duration of action of acetylcholine in cholinergic neurotransmission, suggesting that BuChE may also have an important role in the brain. Acetylcholine 30-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 12898348-1 2003 We have investigated the effect of ganstigmine (CHF2819), a novel geneserine derived acetylcholinesterase (AChE) inhibitor, on the expression and metabolism of the amyloid precursor protein (APP) in neuroblastoma cell line SH-SY5Y. ganstigmine 35-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 15259428-4 2003 The primary action is the irreversible inhibition of acetylcholinesterase, resulting in the accumulation of acetylcholine and subsequent overstimulation of the nicotinic and muscarinic acetylcholine receptors, resulting in cholinergic effects. Acetylcholine 108-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 14563166-0 2003 Total syntheses of the AChE inhibitors (-)-arisugacins F and G. arisugacin 39-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 12860856-0 2003 Acetylcholinesterase inhibition with pyridostigmine improves heart rate recovery after maximal exercise in patients with chronic heart failure. Pyridostigmine Bromide 37-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 12860856-1 2003 OBJECTIVE: To characterise the effects of acetylcholinesterase inhibition with pyridostigmine on parasympathetic tone in patients with chronic heart failure (CHF). Pyridostigmine Bromide 79-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 12860856-10 2003 CONCLUSIONS: Acetylcholinesterase inhibition with pyridostigmine increased heart rate recovery at one minute but not at three minutes after exercise. Pyridostigmine Bromide 50-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-33 12898348-5 2003 The data obtained in the long term experiments demonstrate that continuous inhibition of AchE obtained with 100 nM ganstigmine following an exposure of 24 hours did not influence APP isoforms expression. ganstigmine 115-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 12853469-1 2003 The catalytic domain of acetylcholinesterase AChE(T) subunits is followed by a C-terminal T peptide which mediates their association with the proline-rich attachment domain (PRAD) of anchoring proteins. Proline 142-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 12853469-1 2003 The catalytic domain of acetylcholinesterase AChE(T) subunits is followed by a C-terminal T peptide which mediates their association with the proline-rich attachment domain (PRAD) of anchoring proteins. Proline 142-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 12852840-7 2003 CONCLUSION: It is an effective way to isolate the specific AChE inhibitor from the vast oligonucleotide combinatorial library by virtue of SELEX. Oligonucleotides 88-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 12628460-3 2003 Monolayers of KC were treated overnight with 0.25 mM of the cholinergic agonist carbachol (CCh) or the acetylcholinesterase inhibitor pyridostigmine bromide (PBr). Pyridostigmine Bromide 134-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 12707285-5 2003 Using tissue-cultured skeletal muscle we show that CGRP stimulates an increase in intracellular cAMP that in turn initiates down-regulation of acetylcholinesterase expression at the transcriptional level, and, more specifically, inhibits expression of the synaptically localized collagen-tailed form of the enzyme. Cyclic AMP 96-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 12773032-0 2003 3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer"s disease therapy. AP 2238 0-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 12773032-0 2003 3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer"s disease therapy. AP 2238 0-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 12773032-0 2003 3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer"s disease therapy. AP 2238 73-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 12773032-0 2003 3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer"s disease therapy. AP 2238 73-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 12773032-2 2003 We present here, for the first time, a direct evidence of the Abeta antiaggregating action of an AChE inhibitor (AP2238) purposely designed to bind at both the catalytic and the peripheral sites of the human enzyme. AP 2238 113-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 12837382-2 2003 1,7-Heptylene-bis-N,N"-syn-2-pyridiniumaldoxime, the most potent of the alkylene-linked dimeric reactivators, was readily synthesized using bistriflate and is 100 times more potent than 2-PAM in reactivating hAChE poisoned by isoflurophate. 1,7-HEPTYLENE-BIS-N,N'-SYN-2-PYRIDINIUMALDOXIME 0-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-213 12837382-2 2003 1,7-Heptylene-bis-N,N"-syn-2-pyridiniumaldoxime, the most potent of the alkylene-linked dimeric reactivators, was readily synthesized using bistriflate and is 100 times more potent than 2-PAM in reactivating hAChE poisoned by isoflurophate. bistriflate 140-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-213 12837382-4 2003 Further, they suggest that the improved performance of dimeric oximes is conferred by two-site binding with one oxime pointing toward the diisopropyl ester at the catalytic site of hAChE and the other anchored at the peripheral site. Oximes 63-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-186 12837382-4 2003 Further, they suggest that the improved performance of dimeric oximes is conferred by two-site binding with one oxime pointing toward the diisopropyl ester at the catalytic site of hAChE and the other anchored at the peripheral site. Oximes 63-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-186 12837382-4 2003 Further, they suggest that the improved performance of dimeric oximes is conferred by two-site binding with one oxime pointing toward the diisopropyl ester at the catalytic site of hAChE and the other anchored at the peripheral site. diisopropyl adipate 138-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-186 15034265-1 2003 Acetylcholinesterase (AChE) was the first identified synaptic component, characterized by its catalytic affinity for choline esters, and for a long time provided the conceptual scaffold for studies of the neuromuscular junction (NMJ). choline esters 117-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 15034265-1 2003 Acetylcholinesterase (AChE) was the first identified synaptic component, characterized by its catalytic affinity for choline esters, and for a long time provided the conceptual scaffold for studies of the neuromuscular junction (NMJ). choline esters 117-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 12721372-6 2003 Remarkably, acetylcholinesterase (AChE) inhibitors that act on the brain AChE suppressed both cocaine- and morphine-induced conditioned place preference and blocked the induction and persistence of cocaine-evoked hyperlocomotion. Cocaine 94-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 12721372-6 2003 Remarkably, acetylcholinesterase (AChE) inhibitors that act on the brain AChE suppressed both cocaine- and morphine-induced conditioned place preference and blocked the induction and persistence of cocaine-evoked hyperlocomotion. Cocaine 94-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 12721372-6 2003 Remarkably, acetylcholinesterase (AChE) inhibitors that act on the brain AChE suppressed both cocaine- and morphine-induced conditioned place preference and blocked the induction and persistence of cocaine-evoked hyperlocomotion. Cocaine 94-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 12721372-6 2003 Remarkably, acetylcholinesterase (AChE) inhibitors that act on the brain AChE suppressed both cocaine- and morphine-induced conditioned place preference and blocked the induction and persistence of cocaine-evoked hyperlocomotion. Morphine 107-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 12721372-6 2003 Remarkably, acetylcholinesterase (AChE) inhibitors that act on the brain AChE suppressed both cocaine- and morphine-induced conditioned place preference and blocked the induction and persistence of cocaine-evoked hyperlocomotion. Morphine 107-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 12721372-6 2003 Remarkably, acetylcholinesterase (AChE) inhibitors that act on the brain AChE suppressed both cocaine- and morphine-induced conditioned place preference and blocked the induction and persistence of cocaine-evoked hyperlocomotion. Morphine 107-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 12721372-6 2003 Remarkably, acetylcholinesterase (AChE) inhibitors that act on the brain AChE suppressed both cocaine- and morphine-induced conditioned place preference and blocked the induction and persistence of cocaine-evoked hyperlocomotion. Cocaine 198-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 12721372-6 2003 Remarkably, acetylcholinesterase (AChE) inhibitors that act on the brain AChE suppressed both cocaine- and morphine-induced conditioned place preference and blocked the induction and persistence of cocaine-evoked hyperlocomotion. Cocaine 198-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 12721372-6 2003 Remarkably, acetylcholinesterase (AChE) inhibitors that act on the brain AChE suppressed both cocaine- and morphine-induced conditioned place preference and blocked the induction and persistence of cocaine-evoked hyperlocomotion. Cocaine 198-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 12721372-8 2003 These results demonstrate that centrally active AChE inhibitors prevent long-lasting behavioral abnormalities associated with cocaine and morphine addictions by potentiating the actions of ACh released from the NAc cholinergic neurons. Cocaine 126-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 12721372-8 2003 These results demonstrate that centrally active AChE inhibitors prevent long-lasting behavioral abnormalities associated with cocaine and morphine addictions by potentiating the actions of ACh released from the NAc cholinergic neurons. Morphine 138-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 12782920-14 2003 Ganstigmine, a novel cholinesterase inhibitor, was well tolerated within a dosing range of 5 to 10 mg. Once-daily dosing is supported by data on acetylcholinesterase inhibition. ganstigmine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-35 12782920-14 2003 Ganstigmine, a novel cholinesterase inhibitor, was well tolerated within a dosing range of 5 to 10 mg. Once-daily dosing is supported by data on acetylcholinesterase inhibition. ganstigmine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 14565292-0 2003 Non-inhibition of acetylcholinesterase by cycloSal nucleotides. cyclosal nucleotides 42-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 14565292-1 2003 An acetylcholinesterase (AChE) assay based on the Rappaport method was established to investigate the behaviour of several cycloSal nucleotides against AChE from electrophorus electricus and human sources (purified enzymes). cyclosal nucleotides 123-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 3-23 14565292-1 2003 An acetylcholinesterase (AChE) assay based on the Rappaport method was established to investigate the behaviour of several cycloSal nucleotides against AChE from electrophorus electricus and human sources (purified enzymes). cyclosal nucleotides 123-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 14565292-2 2003 AChE is a physiologically essential enzyme as it catalyzes the hydrolysis of the neurotransmitter acetylcholine. Acetylcholine 98-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 12724174-2 2003 We measured brain acetylcholinesterase (AChE) activity in 54 patients with AD and in 22 normal controls by positron emission tomography and N-[(11)C]methylpiperidin-4-yl acetate to characterize the cholinergic pathology in AD. N-methylpiperidin-4-yl acetate 140-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 24944370-1 2003 BACKGROUND: Cholinesterase (ChE) inhibitors currently used in the treatment of Alzheimer"s disease (AD) are the acetylcholinesterase (AChE)-selective inhibitors, donepezil and galantamine, and the dual AChE and butyrylcholinesterase (BuChE) inhibitor, rivastigmine. Galantamine 176-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 24944370-1 2003 BACKGROUND: Cholinesterase (ChE) inhibitors currently used in the treatment of Alzheimer"s disease (AD) are the acetylcholinesterase (AChE)-selective inhibitors, donepezil and galantamine, and the dual AChE and butyrylcholinesterase (BuChE) inhibitor, rivastigmine. Galantamine 176-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-206 24944370-1 2003 BACKGROUND: Cholinesterase (ChE) inhibitors currently used in the treatment of Alzheimer"s disease (AD) are the acetylcholinesterase (AChE)-selective inhibitors, donepezil and galantamine, and the dual AChE and butyrylcholinesterase (BuChE) inhibitor, rivastigmine. Rivastigmine 252-264 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 12716251-1 2003 BACKGROUND: In clinical trials, sleep problems have been identified as side effects of donepezil, an acetylcholinesterase (AChE)-inhibiting medication for the treatment of Alzheimer"s disease (AD). Donepezil 87-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 12716251-1 2003 BACKGROUND: In clinical trials, sleep problems have been identified as side effects of donepezil, an acetylcholinesterase (AChE)-inhibiting medication for the treatment of Alzheimer"s disease (AD). Donepezil 87-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 14582250-6 2003 organophosphorus pesticides (OPs) have been the first class addressed, based on the common mechanism of acetylcholinesterase inhibition. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 14582250-6 2003 organophosphorus pesticides (OPs) have been the first class addressed, based on the common mechanism of acetylcholinesterase inhibition. OPS 29-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 12898161-5 2003 Increased AChE activity around submucosal vessels was found in 9/16 (56%) cases with isolated IND, 3/11 (27%) cases of IND associated with HD, 5/23 (21%) isolated HD cases and 0/6 controls. indole 94-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-14 12898161-5 2003 Increased AChE activity around submucosal vessels was found in 9/16 (56%) cases with isolated IND, 3/11 (27%) cases of IND associated with HD, 5/23 (21%) isolated HD cases and 0/6 controls. indole 119-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-14 15088511-2 2003 The approach to the treatment of Alzheimer"s dementia has been greatly modified by the acetylcholinesterase inhibitor drugs, first donepezil (Aricept) and then rivastigmine (Exelon) and galantamine (Reminyl), and the ever-increasing number of demented people forces us to be familiar with their use. Donepezil 131-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 15088511-2 2003 The approach to the treatment of Alzheimer"s dementia has been greatly modified by the acetylcholinesterase inhibitor drugs, first donepezil (Aricept) and then rivastigmine (Exelon) and galantamine (Reminyl), and the ever-increasing number of demented people forces us to be familiar with their use. Donepezil 142-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 15088511-2 2003 The approach to the treatment of Alzheimer"s dementia has been greatly modified by the acetylcholinesterase inhibitor drugs, first donepezil (Aricept) and then rivastigmine (Exelon) and galantamine (Reminyl), and the ever-increasing number of demented people forces us to be familiar with their use. Rivastigmine 174-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 15088511-2 2003 The approach to the treatment of Alzheimer"s dementia has been greatly modified by the acetylcholinesterase inhibitor drugs, first donepezil (Aricept) and then rivastigmine (Exelon) and galantamine (Reminyl), and the ever-increasing number of demented people forces us to be familiar with their use. Galantamine 199-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 12742124-1 2003 Galantamine is an acetylcholinesterase inhibitor, recently approved for the treatment of mild-to-moderate Alzheimer"s disease. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 12837382-1 2003 To improve the potency of 2-pralidoxime (2-PAM) for treating organophosphate poisoning, we dimerized 2-PAM and its analogs according to Wilson"s pioneering work and the 3D structure of human acetylcholinesterase (hAChE) inactivated by isoflurophate. 2-pralidoxime 26-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-218 14748471-11 2003 INTERPRETATION & CONCLUSION: In acute organophosphate poisoning, severe and prolonged acetylcholinesterase inhibition is associated with oxidative stress, detected in erythrocyte membranes, that occurs early in the course of poisoning and may contribute to the development and severity of intermediate syndrome. Adenosine Monophosphate 16-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 14748471-11 2003 INTERPRETATION & CONCLUSION: In acute organophosphate poisoning, severe and prolonged acetylcholinesterase inhibition is associated with oxidative stress, detected in erythrocyte membranes, that occurs early in the course of poisoning and may contribute to the development and severity of intermediate syndrome. Organophosphates 42-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 12731886-9 2003 Values of a >1 give rise to a hydrolysis profile called substrate activation, and the AChE site-specific mutant W86F, and to a lesser extent wild-type human AChE itself, showed substrate activation with acetylthiocholine as the substrate. Acetylthiocholine 206-223 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 12731886-9 2003 Values of a >1 give rise to a hydrolysis profile called substrate activation, and the AChE site-specific mutant W86F, and to a lesser extent wild-type human AChE itself, showed substrate activation with acetylthiocholine as the substrate. Acetylthiocholine 206-223 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 12706567-1 2003 The optical biosensor consisting of GST and acetylcholinesterase (AChE)-immobilized gel film was developed to detect captan and organophosphorus compounds simultaneously in contaminated water. Captan 117-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 12706567-1 2003 The optical biosensor consisting of GST and acetylcholinesterase (AChE)-immobilized gel film was developed to detect captan and organophosphorus compounds simultaneously in contaminated water. Captan 117-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 12706567-1 2003 The optical biosensor consisting of GST and acetylcholinesterase (AChE)-immobilized gel film was developed to detect captan and organophosphorus compounds simultaneously in contaminated water. Organophosphorus Compounds 128-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 12706567-1 2003 The optical biosensor consisting of GST and acetylcholinesterase (AChE)-immobilized gel film was developed to detect captan and organophosphorus compounds simultaneously in contaminated water. Organophosphorus Compounds 128-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 12706567-1 2003 The optical biosensor consisting of GST and acetylcholinesterase (AChE)-immobilized gel film was developed to detect captan and organophosphorus compounds simultaneously in contaminated water. Water 186-191 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 12706567-1 2003 The optical biosensor consisting of GST and acetylcholinesterase (AChE)-immobilized gel film was developed to detect captan and organophosphorus compounds simultaneously in contaminated water. Water 186-191 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 12706567-2 2003 The sensing scheme was based on the measurement of decrease of products formation (s-(2,4-dinitrobenzene) glutathione and alpha-naphthol by GST and AChE, respectively) due to the inhibition by captan and organophosphorus compounds. s-(2,4-dinitrobenzene) glutathione 83-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 12706567-2 2003 The sensing scheme was based on the measurement of decrease of products formation (s-(2,4-dinitrobenzene) glutathione and alpha-naphthol by GST and AChE, respectively) due to the inhibition by captan and organophosphorus compounds. 1-naphthol 122-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 12706567-2 2003 The sensing scheme was based on the measurement of decrease of products formation (s-(2,4-dinitrobenzene) glutathione and alpha-naphthol by GST and AChE, respectively) due to the inhibition by captan and organophosphorus compounds. Captan 193-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 12706567-2 2003 The sensing scheme was based on the measurement of decrease of products formation (s-(2,4-dinitrobenzene) glutathione and alpha-naphthol by GST and AChE, respectively) due to the inhibition by captan and organophosphorus compounds. organophosphorus 204-220 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 12706567-4 2003 It was observed that AChE was inhibited by both captan and organophosphorus compounds, and GST was inhibited only by captan. Captan 48-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 12706567-4 2003 It was observed that AChE was inhibited by both captan and organophosphorus compounds, and GST was inhibited only by captan. organophosphorus 59-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 12706585-1 2003 Competitive inhibitors of acetylcholinesterase (AChE) are detected using an evanescent wave technique to monitor changes in the absorbance spectrum of an AChE-monosulfonate tetraphenyl porphyrin (TPPS(1)) complex immobilized on the surface of a glass slide. monosulfonate tetraphenyl porphyrin 159-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 12706585-1 2003 Competitive inhibitors of acetylcholinesterase (AChE) are detected using an evanescent wave technique to monitor changes in the absorbance spectrum of an AChE-monosulfonate tetraphenyl porphyrin (TPPS(1)) complex immobilized on the surface of a glass slide. monosulfonate tetraphenyl porphyrin 159-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-158 12706585-1 2003 Competitive inhibitors of acetylcholinesterase (AChE) are detected using an evanescent wave technique to monitor changes in the absorbance spectrum of an AChE-monosulfonate tetraphenyl porphyrin (TPPS(1)) complex immobilized on the surface of a glass slide. tetraphenylporphine sulfonate 196-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 12706585-1 2003 Competitive inhibitors of acetylcholinesterase (AChE) are detected using an evanescent wave technique to monitor changes in the absorbance spectrum of an AChE-monosulfonate tetraphenyl porphyrin (TPPS(1)) complex immobilized on the surface of a glass slide. tetraphenylporphine sulfonate 196-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-158 15352644-4 2003 Preliminary studies with donepezil, a centrally acting acetylcholinesterase (AChE) inhibitor approved for use in Alzheimer"s disease, have suggested at least short-term benefit in treating opiate-related sedation. Donepezil 25-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 15352644-4 2003 Preliminary studies with donepezil, a centrally acting acetylcholinesterase (AChE) inhibitor approved for use in Alzheimer"s disease, have suggested at least short-term benefit in treating opiate-related sedation. Donepezil 25-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 15352644-4 2003 Preliminary studies with donepezil, a centrally acting acetylcholinesterase (AChE) inhibitor approved for use in Alzheimer"s disease, have suggested at least short-term benefit in treating opiate-related sedation. Opiate Alkaloids 189-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 15352644-4 2003 Preliminary studies with donepezil, a centrally acting acetylcholinesterase (AChE) inhibitor approved for use in Alzheimer"s disease, have suggested at least short-term benefit in treating opiate-related sedation. Opiate Alkaloids 189-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 12604134-3 2003 Rate factors calculated for various sites in acetylcholinesterase mRNA correlated with sites found previously to be experimentally accessible for hybridization to antisense oligonucleotides. Oligonucleotides 173-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 12635450-3 2003 Galantamine acts both as a reversible competitive inhibitor of acetylcholinesterase (AChE) and as an allosteric modulator of nicotinic acetylcholine receptors. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 12635450-3 2003 Galantamine acts both as a reversible competitive inhibitor of acetylcholinesterase (AChE) and as an allosteric modulator of nicotinic acetylcholine receptors. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 12635450-3 2003 Galantamine acts both as a reversible competitive inhibitor of acetylcholinesterase (AChE) and as an allosteric modulator of nicotinic acetylcholine receptors. Acetylcholine 63-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 12635450-11 2003 Galantamine provides the clinician with another choice of an AChE inhibitor for use in treating AD. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 12747008-0 2003 3,4-methylenedioxymethamphetamine (MDMA) abuse markedly inhibits acetylcholinesterase activity and induces severe oxidative damage and liperoxidative damage. N-Methyl-3,4-methylenedioxyamphetamine 0-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 12747008-0 2003 3,4-methylenedioxymethamphetamine (MDMA) abuse markedly inhibits acetylcholinesterase activity and induces severe oxidative damage and liperoxidative damage. N-Methyl-3,4-methylenedioxyamphetamine 35-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 12747008-1 2003 OBJECTIVE: To investigate whether 3,4-methylenedioxymethamphetamine (MDMA) abuse produces another neurotoxicity which may significantly inhibit the acetylcholinesterase activity and result in severe oxidative damage and liperoxidative damage to MDMA abusers. N-Methyl-3,4-methylenedioxyamphetamine 34-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-168 12747008-1 2003 OBJECTIVE: To investigate whether 3,4-methylenedioxymethamphetamine (MDMA) abuse produces another neurotoxicity which may significantly inhibit the acetylcholinesterase activity and result in severe oxidative damage and liperoxidative damage to MDMA abusers. N-Methyl-3,4-methylenedioxyamphetamine 69-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-168 12747008-4 2003 The Pearson product-moment correlation analysis between the values of AChE and biochemical parameters in 120 MDMA abusers showed that significant linear negative correlation was present between the activity of AChE and the levels of LPO in plasma and erythrocytes (P < 0.0005-0.0001), while significant linear positive correlation was observed between the activity of AchE and the activities of SOD, CAT and GPX (P < 0.0001). Lipid Peroxides 233-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 12747008-4 2003 The Pearson product-moment correlation analysis between the values of AChE and biochemical parameters in 120 MDMA abusers showed that significant linear negative correlation was present between the activity of AChE and the levels of LPO in plasma and erythrocytes (P < 0.0005-0.0001), while significant linear positive correlation was observed between the activity of AchE and the activities of SOD, CAT and GPX (P < 0.0001). Lipid Peroxides 233-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-214 12747008-4 2003 The Pearson product-moment correlation analysis between the values of AChE and biochemical parameters in 120 MDMA abusers showed that significant linear negative correlation was present between the activity of AChE and the levels of LPO in plasma and erythrocytes (P < 0.0005-0.0001), while significant linear positive correlation was observed between the activity of AchE and the activities of SOD, CAT and GPX (P < 0.0001). Lipid Peroxides 233-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 371-375 12747008-6 2003 CONCLUSION: The findings in the present study suggest that MDMA abuse can induce another neurotoxicity that significantly inhibits acetylcholinesterase activity and aggravates a series of free radical chain reactions and oxidative stress in the bodies of MDMA abusers, thereby resulting in severe neural, oxidative and lipoperoxidative damages in MDMA abusers. N-Methyl-3,4-methylenedioxyamphetamine 59-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-151 12651193-2 2003 Biomarkers that measure toxic effects at the molecular level (e.g., the inhibition of brain acetylcholinesterase activity by organophosphorus pesticides) have been shown to provide rapid quantitative predictions of a toxic effect upon individuals in laboratory studies. organophosphorus 125-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 12745021-0 2003 N-methylpiperidinemethyl, N-methylpyrrolidyl and N-methylpyrrolidinemethyl esters as PET radiotracers for acetylcholinesterase activity. n-methylpiperidinemethyl, n-methylpyrrolidyl and n-methylpyrrolidinemethyl esters 0-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 12745021-3 2003 Acetylcholinesterase exhibited a preference for primary esters 1 and for the R-isomers of both 1 and 2. Esters 56-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 12554434-1 2003 Methyl parathion is an organophosphorus (OP) insecticide with insecticidal properties derived from acetylcholinesterase (AChE) inhibition; this same property is also the root of its toxicity in humans. organophosphorus 23-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 12604096-2 2003 The long-acting AChE inhibitor donepezil (Aricept) is used to improve memory and other aspects of cognition in AD patients. Donepezil 31-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 12604096-2 2003 The long-acting AChE inhibitor donepezil (Aricept) is used to improve memory and other aspects of cognition in AD patients. Donepezil 42-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 12609505-8 2003 Both patients presented a novel splicing mutation (IVS1-1G-->A) affecting the exon encoding the proline-rich attachment domain (PRAD), which interacts with acetylcholinesterase. Proline 99-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 12466963-6 2002 Surprisingly, GASP, a fusion product of green fluorescence protein (GFP) and ASP(67), a peptide composed of the 67 C-terminal amino acid residues of AChE-S, localized to COS1 cell nuclei. Aspartic Acid 15-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 12554434-1 2003 Methyl parathion is an organophosphorus (OP) insecticide with insecticidal properties derived from acetylcholinesterase (AChE) inhibition; this same property is also the root of its toxicity in humans. Methyl Parathion 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 12554434-1 2003 Methyl parathion is an organophosphorus (OP) insecticide with insecticidal properties derived from acetylcholinesterase (AChE) inhibition; this same property is also the root of its toxicity in humans. Methyl Parathion 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 12554434-1 2003 Methyl parathion is an organophosphorus (OP) insecticide with insecticidal properties derived from acetylcholinesterase (AChE) inhibition; this same property is also the root of its toxicity in humans. organophosphorus 23-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 12445758-1 2003 The ability of certain organophosphorus (OP) compounds to inhibit acetylcholinesterase (AChE) has made them useful for industrial (insecticides) and military (nerve agents) purposes. organophosphorus 23-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 12445758-1 2003 The ability of certain organophosphorus (OP) compounds to inhibit acetylcholinesterase (AChE) has made them useful for industrial (insecticides) and military (nerve agents) purposes. organophosphorus 23-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 12583695-1 2003 Early treatment of organophosphate (OP) poisoning with oximes results in reactivation of acetylcholinesterase and patient recovery. Organophosphates 19-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 12583695-1 2003 Early treatment of organophosphate (OP) poisoning with oximes results in reactivation of acetylcholinesterase and patient recovery. Oximes 55-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 12583698-3 2003 This implies that, while pralidoxime acts to reverse intoxication by organophosphate compounds due to the otherwise irreversible inhibition of acetylcholinesterase, it does not also supplement this detoxification by hydrolysis of the enzyme"s substrate, acetylcholine. pralidoxime 25-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 12493571-0 2003 Palladium and platinum ions interfere with the measurement of erythrocyte vesiculation by inhibiting the acetylcholinesterase activity of the released spectrin-depleted microvesicles. Palladium 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 12493571-0 2003 Palladium and platinum ions interfere with the measurement of erythrocyte vesiculation by inhibiting the acetylcholinesterase activity of the released spectrin-depleted microvesicles. Platinum 14-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 12493571-1 2003 Palladium (Pd(2+)) and platinum (Pt(2+)) ions were found to inhibit erythrocyte membrane-bound acetylcholinesterase (AChE) with Ki values of 6.0 and 6.5 microg/ml, respectively. Palladium 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 12493571-1 2003 Palladium (Pd(2+)) and platinum (Pt(2+)) ions were found to inhibit erythrocyte membrane-bound acetylcholinesterase (AChE) with Ki values of 6.0 and 6.5 microg/ml, respectively. Palladium 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 12493571-1 2003 Palladium (Pd(2+)) and platinum (Pt(2+)) ions were found to inhibit erythrocyte membrane-bound acetylcholinesterase (AChE) with Ki values of 6.0 and 6.5 microg/ml, respectively. pd(2+) 11-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 12493571-1 2003 Palladium (Pd(2+)) and platinum (Pt(2+)) ions were found to inhibit erythrocyte membrane-bound acetylcholinesterase (AChE) with Ki values of 6.0 and 6.5 microg/ml, respectively. pd(2+) 11-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 12493571-1 2003 Palladium (Pd(2+)) and platinum (Pt(2+)) ions were found to inhibit erythrocyte membrane-bound acetylcholinesterase (AChE) with Ki values of 6.0 and 6.5 microg/ml, respectively. Platinum 23-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 12493571-1 2003 Palladium (Pd(2+)) and platinum (Pt(2+)) ions were found to inhibit erythrocyte membrane-bound acetylcholinesterase (AChE) with Ki values of 6.0 and 6.5 microg/ml, respectively. Platinum 23-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 12493571-1 2003 Palladium (Pd(2+)) and platinum (Pt(2+)) ions were found to inhibit erythrocyte membrane-bound acetylcholinesterase (AChE) with Ki values of 6.0 and 6.5 microg/ml, respectively. Platinum 33-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 12493571-1 2003 Palladium (Pd(2+)) and platinum (Pt(2+)) ions were found to inhibit erythrocyte membrane-bound acetylcholinesterase (AChE) with Ki values of 6.0 and 6.5 microg/ml, respectively. Platinum 33-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 12493571-2 2003 Lineweaver-Burke plots revealed that the inhibition of erythrocyte AChE by both metal ions was competitive in nature. Metals 80-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 12493571-6 2003 Inhibition of AChE activities by both metal ions can thus constitute a potential source of error in vesiculation measurement. Metals 38-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 12493571-8 2003 We observed vesiculation under the experimental condition in Pd(2+)-free controls that was associated with a time-dependent increase in AChE activity were barely detected in the Pd(2+)-spiked specimen because of the masking effect exerted by the metal ions themselves. Metals 246-251 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 14535624-3 2003 The most selective AChE inhibitors, in decreasing sequence, were in order: TAK-147, donepezil and galantamine. TAK 147 75-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 14535624-3 2003 The most selective AChE inhibitors, in decreasing sequence, were in order: TAK-147, donepezil and galantamine. Donepezil 84-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 14535624-3 2003 The most selective AChE inhibitors, in decreasing sequence, were in order: TAK-147, donepezil and galantamine. Galantamine 98-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 14535624-6 2003 Among these inhibitors, tacrine, bis-tacrine, TAK-147, metrifonate and galantamine inhibited both the G1 and G4 AChE forms equally well. Tacrine 24-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 14535624-6 2003 Among these inhibitors, tacrine, bis-tacrine, TAK-147, metrifonate and galantamine inhibited both the G1 and G4 AChE forms equally well. bis-tacrine 33-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 14535624-6 2003 Among these inhibitors, tacrine, bis-tacrine, TAK-147, metrifonate and galantamine inhibited both the G1 and G4 AChE forms equally well. TAK 147 46-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 14535624-6 2003 Among these inhibitors, tacrine, bis-tacrine, TAK-147, metrifonate and galantamine inhibited both the G1 and G4 AChE forms equally well. Trichlorfon 55-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 14535624-6 2003 Among these inhibitors, tacrine, bis-tacrine, TAK-147, metrifonate and galantamine inhibited both the G1 and G4 AChE forms equally well. Galantamine 71-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 14535624-8 2003 Only one inhibitor, rivastigmine, displayed preferential inhibition for the G1 form of AChE. Rivastigmine 20-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 12652014-2 2003 The aim of this work was to study the adrenaline effect on erythrocyte membrane fluidity, acetylcholinesterase (AChE) enzyme activity, P(50) and erythrocyte deformability and also to verify if the role of adrenaline on erythrocyte properties is sex-dependent. Epinephrine 38-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 12652014-2 2003 The aim of this work was to study the adrenaline effect on erythrocyte membrane fluidity, acetylcholinesterase (AChE) enzyme activity, P(50) and erythrocyte deformability and also to verify if the role of adrenaline on erythrocyte properties is sex-dependent. Epinephrine 38-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 12652014-5 2003 In female, adrenaline decreases AChE activity either when alpha and beta-adrenergic receptors are blocked (p<or=0.01) or when they are not. Epinephrine 11-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 12652014-6 2003 In male, adrenaline increases AChE activity when none of adrenergic receptors are blocked. Epinephrine 9-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 14674789-7 2003 Galantamine works by inhibiting acetylcholinesterase and by allosterically modulating nicotinic receptors. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 14594523-3 2003 All patients were treated with galantamine that may enhance cholinergic function in the brain by inhibiting acetylcholinesterase and potentiating the effects of acetylcholine at nicotinic acetylcholine receptors. Galantamine 31-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 16191240-2 2003 OBJECTIVE: To examine the population characteristics in patients with VaD enrolled in two randomized, double-blind, placebo-controlled, 24-week clinical trials of the efficacy and tolerability of the acetylcholinesterase inhibitor donepezil. Donepezil 231-240 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-220 14501021-8 2003 However, acetylcholinesterase inhibitors, such as donepezil (Aricept), which potentiate cholinergic neurotransmission, do have a therapeutic role in the management of AD and so the M1 receptor remains a viable therapeutic target. Donepezil 61-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 12701885-2 2003 Acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BuChE, EC 3.1.1.8) are serine hydrolase enzymes that catalyze the hydrolysis of acetylcholine. Acetylcholine 147-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 12701885-2 2003 Acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BuChE, EC 3.1.1.8) are serine hydrolase enzymes that catalyze the hydrolysis of acetylcholine. Acetylcholine 147-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 12701885-4 2003 (-) Huperzine A is an inhibitor of AChE and is being considered for the treatment of Alzheimer"s disease. huperzine A 4-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 12701885-12 2003 (-) Huperzine A inhibited the aryl acylamidase activities of both AChE and BuChE. huperzine A 4-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 12701885-14 2003 (+/-) Huperzine A inhibited this function in AChE but stimulated BuChE aryl acylamidase suggesting that the (+) enantiomer is a powerful activator of this enzyme activity. huperzine A 6-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 12618125-1 2003 Pyridostigmine, a carbamate acetylcholinesterase (AChE) inhibitor, is routinely employed in the treatment of the autoimmune disease myasthenia gravis. Pyridostigmine Bromide 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 12618125-9 2003 This mechanism may explain central side effects previously attributed to this drug as well as the potency of AChE inhibitors, including nerve-gas agents and organophosphate pesticides, in the initiation of cortical synchronization, epileptic discharge, and excitotoxic damage. Organophosphates 157-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 12686754-10 2003 These data suggest that [5-(11)C-methoxy]donepezil can be potentially useful to image AChE non-invasively in the human brain by positron emission tomography. (5-methoxy)donepezil 24-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 12502352-2 2003 Tacrine-based AChE and BuChE inhibitors were designed by investigating the topology of the active site gorge of the two enzymes. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 12502352-4 2003 The nitrogen-containing homobivalent ligands 3e,g and the sulfur-containing 3h validated the hypothesis of extra sites of interaction in the AChE and BuChE active site gorges. Nitrogen 4-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 12502352-4 2003 The nitrogen-containing homobivalent ligands 3e,g and the sulfur-containing 3h validated the hypothesis of extra sites of interaction in the AChE and BuChE active site gorges. Sulfur 58-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 12502352-4 2003 The nitrogen-containing homobivalent ligands 3e,g and the sulfur-containing 3h validated the hypothesis of extra sites of interaction in the AChE and BuChE active site gorges. Tritium 76-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 14687441-6 2003 A number of open-label studies, where patients were switched from donepezil to rivastigmine, have indicated that approximately 50% of patients experiencing a lack/loss of efficacy with donepezil (a selective acetylcholinesterase [AChE] inhibitor) respond to subsequent treatment with rivastigmine (a dual AChE and butyrylcholinesterase inhibitor). Rivastigmine 79-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-228 14687441-6 2003 A number of open-label studies, where patients were switched from donepezil to rivastigmine, have indicated that approximately 50% of patients experiencing a lack/loss of efficacy with donepezil (a selective acetylcholinesterase [AChE] inhibitor) respond to subsequent treatment with rivastigmine (a dual AChE and butyrylcholinesterase inhibitor). Rivastigmine 79-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 230-234 14687441-6 2003 A number of open-label studies, where patients were switched from donepezil to rivastigmine, have indicated that approximately 50% of patients experiencing a lack/loss of efficacy with donepezil (a selective acetylcholinesterase [AChE] inhibitor) respond to subsequent treatment with rivastigmine (a dual AChE and butyrylcholinesterase inhibitor). Donepezil 185-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-228 14687441-6 2003 A number of open-label studies, where patients were switched from donepezil to rivastigmine, have indicated that approximately 50% of patients experiencing a lack/loss of efficacy with donepezil (a selective acetylcholinesterase [AChE] inhibitor) respond to subsequent treatment with rivastigmine (a dual AChE and butyrylcholinesterase inhibitor). Donepezil 185-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 230-234 14687441-6 2003 A number of open-label studies, where patients were switched from donepezil to rivastigmine, have indicated that approximately 50% of patients experiencing a lack/loss of efficacy with donepezil (a selective acetylcholinesterase [AChE] inhibitor) respond to subsequent treatment with rivastigmine (a dual AChE and butyrylcholinesterase inhibitor). Rivastigmine 284-296 acetylcholinesterase (Cartwright blood group) Homo sapiens 230-234 12688400-0 2003 Acetylcholinesterase inhibitor (donepezil hydrochloride) reduces heart rate variability. Donepezil 32-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 12688400-1 2003 An acetylcholinesterase inhibitor (donepezil hydrochloride) has recently been used for the treatment of senile dementia of Alzheimer type. Donepezil 35-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 3-23 14501021-8 2003 However, acetylcholinesterase inhibitors, such as donepezil (Aricept), which potentiate cholinergic neurotransmission, do have a therapeutic role in the management of AD and so the M1 receptor remains a viable therapeutic target. Donepezil 50-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 12507730-2 2003 In this study, using cultured retinal cells as a neuronal model, we analyzed the effect of the synthetic peptide Abeta(25-35) on the activity of AChE, the degradation enzyme of acetylcholine, as well as the involvement of oxidative stress in this process. UNII-042A8N37WH 113-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 12507730-3 2003 The activity of AChE was increased when retinal cells were incubated with Abeta(25-35) (25 microM, 24 h) and antioxidants such as alpha-tocopherol acetate and nitric oxide synthase (NOS) inhibitors were capable of preventing this effect. alpha-Tocopherol 130-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 12507730-6 2003 The data obtained show that the enhancement of AChE activity induced by Abeta(25-35) is mediated by oxidative stress, and that vitamin E and NOS inhibitors, by preventing the compromise of the enzyme activity, can have an important role in the maintenance of acetylcholine synaptic levels, thus preventing or improving cognitive and memory functions of AD patients. Vitamin E 127-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 12507730-6 2003 The data obtained show that the enhancement of AChE activity induced by Abeta(25-35) is mediated by oxidative stress, and that vitamin E and NOS inhibitors, by preventing the compromise of the enzyme activity, can have an important role in the maintenance of acetylcholine synaptic levels, thus preventing or improving cognitive and memory functions of AD patients. Acetylcholine 259-272 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 15000836-1 2003 To determine whether the efficacy of entry and action of antisense oligonucleotides (AS-ODN) on hematopoietic stem cells in vitro could be improved by the addition of polyethylene glycol (PEG), a molecule of PEG was bound to AS- or sense-acetylcholinesterase (AS-ACHE or S-ACHE). Polyethylene Glycols 167-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 263-267 15000836-1 2003 To determine whether the efficacy of entry and action of antisense oligonucleotides (AS-ODN) on hematopoietic stem cells in vitro could be improved by the addition of polyethylene glycol (PEG), a molecule of PEG was bound to AS- or sense-acetylcholinesterase (AS-ACHE or S-ACHE). Polyethylene Glycols 167-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 273-277 15000836-2 2003 The introduction of 0.1-0.5 microM PEG-AS-ACHE or 0.5 microM AS-ACHE into methylcellulose bone marrow (BM) cultures produced a doubling in number of colony-forming unit-granulocyte-erythrocyte-macrophage-megakaryocyte (CFU-GEMM) and a 5-fold increase in cell number of the PEG-ODN. peg-as 35-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 15000836-2 2003 The introduction of 0.1-0.5 microM PEG-AS-ACHE or 0.5 microM AS-ACHE into methylcellulose bone marrow (BM) cultures produced a doubling in number of colony-forming unit-granulocyte-erythrocyte-macrophage-megakaryocyte (CFU-GEMM) and a 5-fold increase in cell number of the PEG-ODN. Arsenic 39-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 15000836-2 2003 The introduction of 0.1-0.5 microM PEG-AS-ACHE or 0.5 microM AS-ACHE into methylcellulose bone marrow (BM) cultures produced a doubling in number of colony-forming unit-granulocyte-erythrocyte-macrophage-megakaryocyte (CFU-GEMM) and a 5-fold increase in cell number of the PEG-ODN. peg-odn 273-280 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 15000836-2 2003 The introduction of 0.1-0.5 microM PEG-AS-ACHE or 0.5 microM AS-ACHE into methylcellulose bone marrow (BM) cultures produced a doubling in number of colony-forming unit-granulocyte-erythrocyte-macrophage-megakaryocyte (CFU-GEMM) and a 5-fold increase in cell number of the PEG-ODN. peg-odn 273-280 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 15000836-4 2003 PEG-AS-ACHE induced higher colony numbers and greatly increased megakaryocyte (MK) formation when compared with PEG and AS-ACHE added separately to the culture. Polyethylene Glycols 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 7-11 15000836-5 2003 In addition, differentials of the CFU-GEMMs indicated there was a direct relationship between MK number and PEG-AS-ACHE concentration. mk number 94-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 15000836-5 2003 In addition, differentials of the CFU-GEMMs indicated there was a direct relationship between MK number and PEG-AS-ACHE concentration. Polyethylene Glycols 108-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 15000836-7 2003 On addition of FITC-PEG-AS-ACHE to the cell cultures, using confocal microscopy, the nuclei of both early and mature MKs were labeled specifically, whereas all other cellular nuclei were negative to the stain. fitc-peg 15-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 15181665-2 2003 OPs act primarily by inhibiting acetylcholinesterase (AChE), thereby allowing acetylcholine to accumulate at cholinergic synapses, disturbing transmission at parasympathetic nerve endings, sympathetic ganglia, neuromuscular endplates and certain CNS regions. Acetylcholine 32-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 15181665-7 2003 In vitro studies with human erythrocyte AChE, which is derived from the same single gene as synaptic AChE, revealed marked differences in the potency and efficacy of pralidoxime, obidoxime, HI 6 and HLo 7, the latter two oximes being considered particularly effective in nerve agent poisoning. pralidoxime 166-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 15181665-7 2003 In vitro studies with human erythrocyte AChE, which is derived from the same single gene as synaptic AChE, revealed marked differences in the potency and efficacy of pralidoxime, obidoxime, HI 6 and HLo 7, the latter two oximes being considered particularly effective in nerve agent poisoning. pralidoxime 166-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 15181665-7 2003 In vitro studies with human erythrocyte AChE, which is derived from the same single gene as synaptic AChE, revealed marked differences in the potency and efficacy of pralidoxime, obidoxime, HI 6 and HLo 7, the latter two oximes being considered particularly effective in nerve agent poisoning. Obidoxime Chloride 179-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 15181665-7 2003 In vitro studies with human erythrocyte AChE, which is derived from the same single gene as synaptic AChE, revealed marked differences in the potency and efficacy of pralidoxime, obidoxime, HI 6 and HLo 7, the latter two oximes being considered particularly effective in nerve agent poisoning. Oximes 221-227 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 15181665-7 2003 In vitro studies with human erythrocyte AChE, which is derived from the same single gene as synaptic AChE, revealed marked differences in the potency and efficacy of pralidoxime, obidoxime, HI 6 and HLo 7, the latter two oximes being considered particularly effective in nerve agent poisoning. Oximes 221-227 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 15181665-16 2003 For obidoxime chloride, the appropriate dosage is a 0.25 g bolus followed by an infusion of 0.75 g/24 h. These concentrations are well tolerated and keep a good portion of AChE in the active state, thereby retarding the AChE aging rate. Obidoxime Chloride 4-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-176 15181665-16 2003 For obidoxime chloride, the appropriate dosage is a 0.25 g bolus followed by an infusion of 0.75 g/24 h. These concentrations are well tolerated and keep a good portion of AChE in the active state, thereby retarding the AChE aging rate. Obidoxime Chloride 4-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 220-224 15181665-17 2003 AChE aging is particularly rapid with dimethyl phosphoryl compounds and may thwart the effective reactivation by oximes, particularly in suicidal poisoning with excessive doses. dimethyl phosphoryl 38-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 15181665-17 2003 AChE aging is particularly rapid with dimethyl phosphoryl compounds and may thwart the effective reactivation by oximes, particularly in suicidal poisoning with excessive doses. Oximes 113-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 12436423-7 2002 A high concentration of acetylcholinesterase in the striatum rapidly terminates the ACh signal, and thereby minimizes desensitization of nicotinic acetylcholine receptors. Acetylcholine 84-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 12630661-0 2002 Risk from lithium with acetylcholinesterase inhibitor. Lithium 10-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 12454562-1 2002 Donepezil and rivastigmine are acetylcholinesterase (AChE) inhibitors used to improve cholinergic neurotransmission and cognitive function in Alzheimer"s disease (AD). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 12454562-1 2002 Donepezil and rivastigmine are acetylcholinesterase (AChE) inhibitors used to improve cholinergic neurotransmission and cognitive function in Alzheimer"s disease (AD). Rivastigmine 14-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 12454562-6 2002 Treatment with donepezil reduced the AChE activity (k3 values) in the AD brain by 39% in the frontal (p < 0.001, Bonferroni corrected), 29% in the temporal (p = 0.02, corrected) and 28% in the parietal cortex (p = 0.05, corrected). Donepezil 15-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 12454562-10 2002 The present study provides first evidence for the effect of rivastigmine on cortical AChE activity. Rivastigmine 60-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 12454562-11 2002 Our results indicate that the pooled effects of donepezil and rivastigmine on brain AChE are greater in the frontal cortex compared to the temporal cortex in AD. Donepezil 48-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 12454562-11 2002 Our results indicate that the pooled effects of donepezil and rivastigmine on brain AChE are greater in the frontal cortex compared to the temporal cortex in AD. Rivastigmine 62-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 12417371-5 2002 Galantamine is both a moderate, reversible, competitive acetylcholinesterase inhibitor, and an allosteric modulator of nAChR. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 14694584-3 2002 RESULTS: Acephate and methamidophos could directly inhibit AChE activities in human erythrocyte membrane and rat brain synatosomal membrane in dose- and time-dependent manners in vitro, and this effect was irreversible. acephate 9-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 14694584-3 2002 RESULTS: Acephate and methamidophos could directly inhibit AChE activities in human erythrocyte membrane and rat brain synatosomal membrane in dose- and time-dependent manners in vitro, and this effect was irreversible. methamidophos 22-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 12427014-2 2002 We report that a 14-amino acid synthetic polypeptide whose sequence corresponds to residues 586-599 of the human synaptic or T form of AChE assembles into amyloid fibrils under physiological conditions. 14-amino acid 17-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 12417373-1 2002 Further to recent data indicating that patients with vascular dementia (VaD) show a cholinergic deficit, we aimed to determine whether rivastigmine, a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), has any effects on the symptoms of VaD. Rivastigmine 135-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 191-195 12469000-5 2002 We report the case of a patient with PD and cognitive impairment who developed a marked worsening of motor function, mood, and anxiety in the setting of a pharmacologic challenge study using a 3-mg oral dose of the acetylcholinesterase inhibitor, rivastigmine. Rivastigmine 247-259 acetylcholinesterase (Cartwright blood group) Homo sapiens 215-235 12498995-1 2002 OBJECTIVE: a) To evaluate acetylcholinesterase (AChE) activities in erythrocyte membranes from phenylketonuric (PKU) patients and controls and to correlate with their plasma phenylalanine (Phe), tyrosine (Tyr), alanine (Ala) and dopamine (DA) levels. Phenylalanine 174-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 12498995-1 2002 OBJECTIVE: a) To evaluate acetylcholinesterase (AChE) activities in erythrocyte membranes from phenylketonuric (PKU) patients and controls and to correlate with their plasma phenylalanine (Phe), tyrosine (Tyr), alanine (Ala) and dopamine (DA) levels. Phenylalanine 174-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 12498995-1 2002 OBJECTIVE: a) To evaluate acetylcholinesterase (AChE) activities in erythrocyte membranes from phenylketonuric (PKU) patients and controls and to correlate with their plasma phenylalanine (Phe), tyrosine (Tyr), alanine (Ala) and dopamine (DA) levels. Phenylalanine 189-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 12498995-1 2002 OBJECTIVE: a) To evaluate acetylcholinesterase (AChE) activities in erythrocyte membranes from phenylketonuric (PKU) patients and controls and to correlate with their plasma phenylalanine (Phe), tyrosine (Tyr), alanine (Ala) and dopamine (DA) levels. Phenylalanine 189-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 12498995-1 2002 OBJECTIVE: a) To evaluate acetylcholinesterase (AChE) activities in erythrocyte membranes from phenylketonuric (PKU) patients and controls and to correlate with their plasma phenylalanine (Phe), tyrosine (Tyr), alanine (Ala) and dopamine (DA) levels. Tyrosine 195-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 12498995-1 2002 OBJECTIVE: a) To evaluate acetylcholinesterase (AChE) activities in erythrocyte membranes from phenylketonuric (PKU) patients and controls and to correlate with their plasma phenylalanine (Phe), tyrosine (Tyr), alanine (Ala) and dopamine (DA) levels. Tyrosine 195-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 12498995-1 2002 OBJECTIVE: a) To evaluate acetylcholinesterase (AChE) activities in erythrocyte membranes from phenylketonuric (PKU) patients and controls and to correlate with their plasma phenylalanine (Phe), tyrosine (Tyr), alanine (Ala) and dopamine (DA) levels. Tyrosine 205-208 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 12498995-1 2002 OBJECTIVE: a) To evaluate acetylcholinesterase (AChE) activities in erythrocyte membranes from phenylketonuric (PKU) patients and controls and to correlate with their plasma phenylalanine (Phe), tyrosine (Tyr), alanine (Ala) and dopamine (DA) levels. Tyrosine 205-208 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 12498995-1 2002 OBJECTIVE: a) To evaluate acetylcholinesterase (AChE) activities in erythrocyte membranes from phenylketonuric (PKU) patients and controls and to correlate with their plasma phenylalanine (Phe), tyrosine (Tyr), alanine (Ala) and dopamine (DA) levels. Alanine 180-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 12498995-1 2002 OBJECTIVE: a) To evaluate acetylcholinesterase (AChE) activities in erythrocyte membranes from phenylketonuric (PKU) patients and controls and to correlate with their plasma phenylalanine (Phe), tyrosine (Tyr), alanine (Ala) and dopamine (DA) levels. Alanine 180-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 12498995-1 2002 OBJECTIVE: a) To evaluate acetylcholinesterase (AChE) activities in erythrocyte membranes from phenylketonuric (PKU) patients and controls and to correlate with their plasma phenylalanine (Phe), tyrosine (Tyr), alanine (Ala) and dopamine (DA) levels. Alanine 220-223 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 12498995-1 2002 OBJECTIVE: a) To evaluate acetylcholinesterase (AChE) activities in erythrocyte membranes from phenylketonuric (PKU) patients and controls and to correlate with their plasma phenylalanine (Phe), tyrosine (Tyr), alanine (Ala) and dopamine (DA) levels. Alanine 220-223 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 12498995-1 2002 OBJECTIVE: a) To evaluate acetylcholinesterase (AChE) activities in erythrocyte membranes from phenylketonuric (PKU) patients and controls and to correlate with their plasma phenylalanine (Phe), tyrosine (Tyr), alanine (Ala) and dopamine (DA) levels. Dopamine 229-237 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 12498995-1 2002 OBJECTIVE: a) To evaluate acetylcholinesterase (AChE) activities in erythrocyte membranes from phenylketonuric (PKU) patients and controls and to correlate with their plasma phenylalanine (Phe), tyrosine (Tyr), alanine (Ala) and dopamine (DA) levels. Dopamine 229-237 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 12498995-1 2002 OBJECTIVE: a) To evaluate acetylcholinesterase (AChE) activities in erythrocyte membranes from phenylketonuric (PKU) patients and controls and to correlate with their plasma phenylalanine (Phe), tyrosine (Tyr), alanine (Ala) and dopamine (DA) levels. Dopamine 239-241 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 12498995-1 2002 OBJECTIVE: a) To evaluate acetylcholinesterase (AChE) activities in erythrocyte membranes from phenylketonuric (PKU) patients and controls and to correlate with their plasma phenylalanine (Phe), tyrosine (Tyr), alanine (Ala) and dopamine (DA) levels. Dopamine 239-241 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 12498995-2 2002 b) To determine the in vitro effects of Phe, Ala and Phe plus Ala on their AChE activities. Phenylalanine 40-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 12498995-2 2002 b) To determine the in vitro effects of Phe, Ala and Phe plus Ala on their AChE activities. Alanine 45-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 12498995-2 2002 b) To determine the in vitro effects of Phe, Ala and Phe plus Ala on their AChE activities. Phenylalanine 53-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 12498995-2 2002 b) To determine the in vitro effects of Phe, Ala and Phe plus Ala on their AChE activities. Alanine 62-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 12498995-7 2002 Phe negatively correlated with AChE activity and positively with plasma Tyr and DA. Phenylalanine 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 12498995-8 2002 Ala reversed the inhibited AChE by Phe in erythrocyte membranes from healthy children to control values, whereas no reverse effect was observed on the enzyme activity from PKU patients. Alanine 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 12498995-8 2002 Ala reversed the inhibited AChE by Phe in erythrocyte membranes from healthy children to control values, whereas no reverse effect was observed on the enzyme activity from PKU patients. Phenylalanine 35-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 12498995-10 2002 So, high Phe blood levels inhibit AChE in PKU patients, probably resulting in higher acetylcholine concentrations. Phenylalanine 9-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 12498995-10 2002 So, high Phe blood levels inhibit AChE in PKU patients, probably resulting in higher acetylcholine concentrations. Acetylcholine 85-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 12498995-11 2002 b) Determination of AChE in erythrocyte membranes from PKU could be a useful marker for the neurotoxic effects of Phe. Phenylalanine 114-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 12469005-3 2002 A number of studies show beneficial effects in the treatment of BPSD with acetylcholinesterase inhibitors (AChEI). bpsd 64-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 12469005-16 2002 Acetylcholinesterase inhibitors should be considered for the treatment of BPSD before neuroleptic treatment is instituted in AD patients with low levels of irritability and agitation. bpsd 74-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 12422273-2 2002 Acetylcholinesterase (AChE) enzyme activity measurements confirmed the presence of exovesicles released from erythrocyte membranes labeled with DPH, TMA-DPH or C17-HC. Diphenylhexatriene 144-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 12422273-2 2002 Acetylcholinesterase (AChE) enzyme activity measurements confirmed the presence of exovesicles released from erythrocyte membranes labeled with DPH, TMA-DPH or C17-HC. Diphenylhexatriene 144-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 12449529-0 2002 Activated transformations of organophosphorus insecticides in the case of non-AChE inhibitory oxons. organophosphorus 29-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 12449529-1 2002 Many organophosphorus (OP) compounds are of the thiono form and in insects or animals are converted by microsomal mixed function oxidases (MFO) into the oxon forms which inhibit acetylcholinesterase (AChE) and give toxic activity. organophosphorus 5-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-198 12449529-1 2002 Many organophosphorus (OP) compounds are of the thiono form and in insects or animals are converted by microsomal mixed function oxidases (MFO) into the oxon forms which inhibit acetylcholinesterase (AChE) and give toxic activity. organophosphorus 5-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-204 12449529-1 2002 Many organophosphorus (OP) compounds are of the thiono form and in insects or animals are converted by microsomal mixed function oxidases (MFO) into the oxon forms which inhibit acetylcholinesterase (AChE) and give toxic activity. thiono 48-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-198 12449529-2 2002 However, certain S-alkyl phosphorothiolates (RS-P(O) <) such as methamidophos, profenophos and prothiophos oxon are strongly insecticidal, but very poor inhibitors of AChE in vitro. s-alkyl phosphorothiolates 17-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 12449529-2 2002 However, certain S-alkyl phosphorothiolates (RS-P(O) <) such as methamidophos, profenophos and prothiophos oxon are strongly insecticidal, but very poor inhibitors of AChE in vitro. arginylproline 45-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 12449529-2 2002 However, certain S-alkyl phosphorothiolates (RS-P(O) <) such as methamidophos, profenophos and prothiophos oxon are strongly insecticidal, but very poor inhibitors of AChE in vitro. methamidophos 67-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 12449529-2 2002 However, certain S-alkyl phosphorothiolates (RS-P(O) <) such as methamidophos, profenophos and prothiophos oxon are strongly insecticidal, but very poor inhibitors of AChE in vitro. prothiophos oxon 98-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 12449529-3 2002 Their oxons are converted further to the S-oxides, which either inhibit AChE or decompose, depending on the alkyl substituents on the sulfur atom. Oxides 41-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 12449529-3 2002 Their oxons are converted further to the S-oxides, which either inhibit AChE or decompose, depending on the alkyl substituents on the sulfur atom. Sulfur 134-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 12449529-4 2002 It is also inferred in the case of prothiophos oxon that its S-oxide not only inhibits AChE but also conjugates with glutathione (GSH) by the action of glutathione S-transferase (GST), and the conjugate inhibits AChE. prothiophos oxon 35-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 12449529-4 2002 It is also inferred in the case of prothiophos oxon that its S-oxide not only inhibits AChE but also conjugates with glutathione (GSH) by the action of glutathione S-transferase (GST), and the conjugate inhibits AChE. prothiophos oxon 35-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 212-216 12449529-4 2002 It is also inferred in the case of prothiophos oxon that its S-oxide not only inhibits AChE but also conjugates with glutathione (GSH) by the action of glutathione S-transferase (GST), and the conjugate inhibits AChE. Sulfur 61-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 12449529-4 2002 It is also inferred in the case of prothiophos oxon that its S-oxide not only inhibits AChE but also conjugates with glutathione (GSH) by the action of glutathione S-transferase (GST), and the conjugate inhibits AChE. Sulfur 61-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 212-216 12449529-4 2002 It is also inferred in the case of prothiophos oxon that its S-oxide not only inhibits AChE but also conjugates with glutathione (GSH) by the action of glutathione S-transferase (GST), and the conjugate inhibits AChE. Glutathione 117-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 212-216 12449529-4 2002 It is also inferred in the case of prothiophos oxon that its S-oxide not only inhibits AChE but also conjugates with glutathione (GSH) by the action of glutathione S-transferase (GST), and the conjugate inhibits AChE. Glutathione 130-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 212-216 12449529-5 2002 Certain phosphoramidates (R2N-P(O) <) such as isofenphos oxon, schradan and propetamphos oxon are weak AChE inhibitors, but strongly insecticidal. phosphoramidic acid 8-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 12449529-5 2002 Certain phosphoramidates (R2N-P(O) <) such as isofenphos oxon, schradan and propetamphos oxon are weak AChE inhibitors, but strongly insecticidal. r2n-p 26-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 12449529-5 2002 Certain phosphoramidates (R2N-P(O) <) such as isofenphos oxon, schradan and propetamphos oxon are weak AChE inhibitors, but strongly insecticidal. ISOFENPHOS OXON 49-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 12449529-5 2002 Certain phosphoramidates (R2N-P(O) <) such as isofenphos oxon, schradan and propetamphos oxon are weak AChE inhibitors, but strongly insecticidal. octamethyl pyrophosphoramide 66-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 12449529-5 2002 Certain phosphoramidates (R2N-P(O) <) such as isofenphos oxon, schradan and propetamphos oxon are weak AChE inhibitors, but strongly insecticidal. Propetamphos oxon 79-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 12449529-6 2002 It is well known that isofenphos oxon is converted into the stable N-desalkyl form (H2N-P(O) <) by oxidative dealkylation to inhibit AChE. ISOFENPHOS OXON 22-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 12270172-0 2002 Molecular modeling and enzymatic studies of the interaction of a choline analogue and acetylcholinesterase. Choline 65-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 12270172-1 2002 Pivaloyl-choline iodide 1 interactions with acetylcholinesterase (AChE) have been studied by theoretical and enzymatic methods. pivaloyl-choline iodide 0-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 12270172-1 2002 Pivaloyl-choline iodide 1 interactions with acetylcholinesterase (AChE) have been studied by theoretical and enzymatic methods. pivaloyl-choline iodide 0-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 12270172-3 2002 Enzymatic experiments have also supported the same theoretical conclusion indicating that AChE was able to hydrolyze 1 to choline. Choline 122-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 12403587-3 2002 The polymer bilayer provides enhanced selectivity and pendant amino groups for covalent coupling of acetylcholinesterase (AChE) and choline oxidase (ChO) by their reaction with glutaraldehyde. Polymers 4-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 12403587-3 2002 The polymer bilayer provides enhanced selectivity and pendant amino groups for covalent coupling of acetylcholinesterase (AChE) and choline oxidase (ChO) by their reaction with glutaraldehyde. Polymers 4-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 12403587-3 2002 The polymer bilayer provides enhanced selectivity and pendant amino groups for covalent coupling of acetylcholinesterase (AChE) and choline oxidase (ChO) by their reaction with glutaraldehyde. Glutaral 177-191 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 12403587-3 2002 The polymer bilayer provides enhanced selectivity and pendant amino groups for covalent coupling of acetylcholinesterase (AChE) and choline oxidase (ChO) by their reaction with glutaraldehyde. Glutaral 177-191 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 12403587-4 2002 The AChE/ChO-modified electrode was then employed as an end-column detector to determine acetylcholine and choline with and without the internal standard butyrylcholine. Acetylcholine 89-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 12403587-4 2002 The AChE/ChO-modified electrode was then employed as an end-column detector to determine acetylcholine and choline with and without the internal standard butyrylcholine. Choline 95-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 12403587-4 2002 The AChE/ChO-modified electrode was then employed as an end-column detector to determine acetylcholine and choline with and without the internal standard butyrylcholine. butyrylcholine 154-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 12395932-1 2002 Acetylcholinesterase (AChE; EC3.1.1.7) is well known for its role in the hydrolysis of acetylcholine at cholinergic synapses to terminate neurotransmission. Acetylcholine 87-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 12323018-1 2002 Highly efficient acetylcholinesterase (AChE) and serotonin transporter (SERT) dual inhibitors, (S)-4 and (R)-13 were designed and synthesized on the basis of the hypothetical model of AChE active site. (R)-1-phenylethanol 105-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 12323018-1 2002 Highly efficient acetylcholinesterase (AChE) and serotonin transporter (SERT) dual inhibitors, (S)-4 and (R)-13 were designed and synthesized on the basis of the hypothetical model of AChE active site. (R)-1-phenylethanol 105-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 12323018-1 2002 Highly efficient acetylcholinesterase (AChE) and serotonin transporter (SERT) dual inhibitors, (S)-4 and (R)-13 were designed and synthesized on the basis of the hypothetical model of AChE active site. (R)-1-phenylethanol 105-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-188 12373455-1 2002 The well-documented efficacy of HI 6 dichloride in reactivating acetylcholinesterase (AChE) inhibited by nerve agents is curtailed by its poor water-solubility at temperatures below 10 degrees C. This drawback can be circumvented by using HI 6 dimethanesulfonate, which has been developed in our laboratory. hi 6 dichloride 32-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 12373455-1 2002 The well-documented efficacy of HI 6 dichloride in reactivating acetylcholinesterase (AChE) inhibited by nerve agents is curtailed by its poor water-solubility at temperatures below 10 degrees C. This drawback can be circumvented by using HI 6 dimethanesulfonate, which has been developed in our laboratory. hi 6 dichloride 32-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 12373455-1 2002 The well-documented efficacy of HI 6 dichloride in reactivating acetylcholinesterase (AChE) inhibited by nerve agents is curtailed by its poor water-solubility at temperatures below 10 degrees C. This drawback can be circumvented by using HI 6 dimethanesulfonate, which has been developed in our laboratory. Water 143-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 12373455-1 2002 The well-documented efficacy of HI 6 dichloride in reactivating acetylcholinesterase (AChE) inhibited by nerve agents is curtailed by its poor water-solubility at temperatures below 10 degrees C. This drawback can be circumvented by using HI 6 dimethanesulfonate, which has been developed in our laboratory. hi 6 dimethanesulfonate 239-262 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 12373455-1 2002 The well-documented efficacy of HI 6 dichloride in reactivating acetylcholinesterase (AChE) inhibited by nerve agents is curtailed by its poor water-solubility at temperatures below 10 degrees C. This drawback can be circumvented by using HI 6 dimethanesulfonate, which has been developed in our laboratory. hi 6 dimethanesulfonate 239-262 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 12373455-3 2002 The reactivating properties of the two salts were compared on human erythrocyte AChE inhibited with paraoxon, sarin, cyclosarin and agent VX. Paraoxon 100-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 12373455-3 2002 The reactivating properties of the two salts were compared on human erythrocyte AChE inhibited with paraoxon, sarin, cyclosarin and agent VX. cyclohexyl methylphosphonofluoridate 117-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 12395932-1 2002 Acetylcholinesterase (AChE; EC3.1.1.7) is well known for its role in the hydrolysis of acetylcholine at cholinergic synapses to terminate neurotransmission. Acetylcholine 87-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 12450245-4 2002 More recent investigations have assessed acetylcholinesterase (AChE) and cholinesterase (ChE) inhibitors such as donepezil, rivastigmine and galantamine. Donepezil 113-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 12450245-4 2002 More recent investigations have assessed acetylcholinesterase (AChE) and cholinesterase (ChE) inhibitors such as donepezil, rivastigmine and galantamine. Rivastigmine 124-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 12450245-4 2002 More recent investigations have assessed acetylcholinesterase (AChE) and cholinesterase (ChE) inhibitors such as donepezil, rivastigmine and galantamine. Galantamine 141-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 12428764-3 2002 For example, a kinetic abnormality of the acetylcholine receptor (AChR) detected at the single channel level pointed to a kinetic mutation in an AChR subunit; endplate AChR deficiency suggested mutations residing in an AChR subunit or in rapsyn; absence of acetylcholinesterase (AChE) from the endplate predicted mutations in the catalytic or collagen-tailed subunit of this enzyme; and a history of abrupt episodes of apnea associated with a stimulation dependent decrease of endplate potentials and currents implicated proteins concerned with ACh resynthesis or vesicular filling. Acetylcholine 66-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 257-277 12428764-3 2002 For example, a kinetic abnormality of the acetylcholine receptor (AChR) detected at the single channel level pointed to a kinetic mutation in an AChR subunit; endplate AChR deficiency suggested mutations residing in an AChR subunit or in rapsyn; absence of acetylcholinesterase (AChE) from the endplate predicted mutations in the catalytic or collagen-tailed subunit of this enzyme; and a history of abrupt episodes of apnea associated with a stimulation dependent decrease of endplate potentials and currents implicated proteins concerned with ACh resynthesis or vesicular filling. Acetylcholine 66-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 279-283 12140295-6 2002 Mutating the CRE site of human AChE promoter altered the original myogenic profile of the promoter activity and its suppressive response to cAMP. Cyclic AMP 140-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 12182861-0 2002 Quaternary salts of E2020 analogues as acetylcholinesterase inhibitors for the reversal of neuromuscular block. quaternary salts 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 12192064-0 2002 Structural and dynamic properties of water around acetylcholinesterase. Water 37-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 12192064-1 2002 Structural and dynamic properties of water molecules around acetylcholinesterase are examined from a 10-nsec molecular dynamics simulation to help understand how the protein alters water properties. Water 37-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 12192064-1 2002 Structural and dynamic properties of water molecules around acetylcholinesterase are examined from a 10-nsec molecular dynamics simulation to help understand how the protein alters water properties. Water 181-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 12411190-0 2002 [Reactivation and aging of acetylcholinesterase in human brain inhibited by phoxim and phoxim oxon in vitro]. phoxim 76-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 12411190-0 2002 [Reactivation and aging of acetylcholinesterase in human brain inhibited by phoxim and phoxim oxon in vitro]. phoxim oxon 87-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 12411190-1 2002 OBJECTIVE: Inhibition of acetylcholinesterase (AChE) in human brain caused by phoxim or phoxim oxon, their reactivation with oxime and aging of phosphorylated AChE were studied and compared in vitro. Oximes 125-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 12196650-1 2002 OBJECTIVE: To study the long-term dual inhibitory effects of rivastigmine on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in patients with AD. Rivastigmine 61-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 12196650-1 2002 OBJECTIVE: To study the long-term dual inhibitory effects of rivastigmine on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in patients with AD. Rivastigmine 61-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 12196650-10 2002 CONCLUSIONS: Rivastigmine causes persistent inhibition of AChE and BuChE in CSF as well as plasma. Rivastigmine 13-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 12196650-11 2002 The persistent CSF inhibition contrasts with earlier findings after long-term treatment by the reversible ChE inhibitor tacrine, which demonstrated increased AChE activity in the CSF but not in the blood. Tacrine 120-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 12166941-5 2002 Evaluation of their biological action to inhibit human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), ex vivo, demonstrated that the N-oxide (7, 9, 11, 13, 15) and 1,2-oxazine (6, 8, 10, 12, 14) structures possessed similar potencies against AChE, but the latter structures were more potent against BChE. n-oxide 148-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 12166941-5 2002 Evaluation of their biological action to inhibit human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), ex vivo, demonstrated that the N-oxide (7, 9, 11, 13, 15) and 1,2-oxazine (6, 8, 10, 12, 14) structures possessed similar potencies against AChE, but the latter structures were more potent against BChE. n-oxide 148-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 12166941-5 2002 Evaluation of their biological action to inhibit human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), ex vivo, demonstrated that the N-oxide (7, 9, 11, 13, 15) and 1,2-oxazine (6, 8, 10, 12, 14) structures possessed similar potencies against AChE, but the latter structures were more potent against BChE. 1,2-oxazine 179-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 12166941-5 2002 Evaluation of their biological action to inhibit human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), ex vivo, demonstrated that the N-oxide (7, 9, 11, 13, 15) and 1,2-oxazine (6, 8, 10, 12, 14) structures possessed similar potencies against AChE, but the latter structures were more potent against BChE. 1,2-oxazine 179-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 12190157-4 2002 METHODS: Forty patients with NUD and 40 healthy comparison subjects were administered pyridostigmine (the acetylcholinesterase inhibitor, 120 mg), and GH release over a 3-h period was monitored. Pyridostigmine Bromide 86-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 12173251-7 2002 In this trial with only four primates, huperzine selectively inhibits red cell AChE activity whereas pyridostigmine also inhibits plasma butyrylcholinesterase (BuChE). huperzine A 39-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 12101059-3 2002 Indirect electrochemical detection is accomplished at a 25 microm platinum electrode modified by cross-linking the enzymes choline oxidase and acetylcholinesterase with glutaraldehyde. Platinum 66-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 12101059-3 2002 Indirect electrochemical detection is accomplished at a 25 microm platinum electrode modified by cross-linking the enzymes choline oxidase and acetylcholinesterase with glutaraldehyde. Glutaral 169-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 12101059-4 2002 Although in this simple form of electrode fabrication there is a gradual loss of response from the electrochemical detector with time, accurate quantitation is achieved by the addition of butyrylcholine, which is also a substrate for acetylcholinesterase, as an internal standard. butyrylcholine 188-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 234-254 12197759-6 2002 Our calculations indicate that, in the AChE-ACh Michaelis complex, only two hydrogen bonds are formed between the carbonyl oxygen of ACh and the peptidic NH groups of Gly121 and Gly122. Hydrogen 76-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 12197759-6 2002 Our calculations indicate that, in the AChE-ACh Michaelis complex, only two hydrogen bonds are formed between the carbonyl oxygen of ACh and the peptidic NH groups of Gly121 and Gly122. Oxygen 123-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 12207238-0 2002 Detection of organophosphorus insecticides with immobilized acetylcholinesterase - comparative study of two enzyme sensors. organophosphorus 13-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 12207238-4 2002 When phenyl acetate was used as substrate for AChE activity the phenol generated by enzymatic hydrolysis was determined with a second enzyme, tyrosinase. phenyl acetate 5-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 12207238-4 2002 When phenyl acetate was used as substrate for AChE activity the phenol generated by enzymatic hydrolysis was determined with a second enzyme, tyrosinase. Phenol 64-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 12242610-0 2002 Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates. Organophosphates 95-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 12242610-1 2002 Standard treatment of poisoning by organophosphates (OP) includes the administration of an antimuscarinic agent, e.g. atropine, and of an acetylcholinesterase (AChE) reactivator (oxime). Organophosphates 35-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 12242610-1 2002 Standard treatment of poisoning by organophosphates (OP) includes the administration of an antimuscarinic agent, e.g. atropine, and of an acetylcholinesterase (AChE) reactivator (oxime). Oximes 179-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 12242610-1 2002 Standard treatment of poisoning by organophosphates (OP) includes the administration of an antimuscarinic agent, e.g. atropine, and of an acetylcholinesterase (AChE) reactivator (oxime). Oximes 179-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 12410061-2 2002 Galantamine is an inhibitor of acetylcholinesterase and a positive allosteric modulator of nicotinic cholinergic receptors (with a FDA-approved indication for the treatment of patients with mild to moderate Alzheimer disease (AD) under the trade name Reminyl). Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 12410061-7 2002 Galantamine is distinguished from other acetylcholinesterase inhibitors by its positive allosteric modulatory properties, improving the efficiency of transduction of the acetylcholine signal at nicotinic receptors. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 12548360-3 2002 AChE activity in CSF was significantly increased after treatment with donepezil and galantamine; the opposite was observed in the rivastigmine-treated group. Donepezil 70-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 12548360-3 2002 AChE activity in CSF was significantly increased after treatment with donepezil and galantamine; the opposite was observed in the rivastigmine-treated group. Galantamine 84-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 12548360-3 2002 AChE activity in CSF was significantly increased after treatment with donepezil and galantamine; the opposite was observed in the rivastigmine-treated group. Rivastigmine 130-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 12105904-1 2002 A combined molecular dynamics simulation and multiple ligand docking approach is applied to study the binding specificity of acetylcholinesterase (AChE) with its natural substrate acetylcholine (ACh), a family of substrate analogues, and choline. Acetylcholine 125-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 12105904-1 2002 A combined molecular dynamics simulation and multiple ligand docking approach is applied to study the binding specificity of acetylcholinesterase (AChE) with its natural substrate acetylcholine (ACh), a family of substrate analogues, and choline. Acetylcholine 147-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 12105904-1 2002 A combined molecular dynamics simulation and multiple ligand docking approach is applied to study the binding specificity of acetylcholinesterase (AChE) with its natural substrate acetylcholine (ACh), a family of substrate analogues, and choline. Choline 131-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 12105904-4 2002 We find that the presence of ACh in the active site of AChE not only stabilizes the setup of the catalytic triad but also tightens both subsites to achieve better binding. Acetylcholine 29-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 12105320-1 2002 We report a randomized, double-blind, parallel group, placebo-controlled study to test the effects of the acetylcholinesterase inhibitor, donepezil (5 mg/d for 30 days), on aircraft pilot performance in 18 licensed pilots with mean age of 52 years. Donepezil 138-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 12081473-0 2002 The aromatic "trapping" of the catalytic histidine is essential for efficient catalysis in acetylcholinesterase. Histidine 41-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 12207285-0 2002 Synthesis and acetylcholinesterase/butyrylcholinesterase inhibition activity of 4-amino-2, 3-diaryl-5, 6, 7, 8-tetrahydrofuro(and thieno)[2, 3-b]-quinolines, and 4-amino-5, 6, 7, 8, 9-pentahydro-2, 3-diphenylcyclohepta[e]furo(and thieno)-[2, 3-b]pyridines. 4-amino-2, 3-diaryl-5, 6, 7, 8-tetrahydrofuro 80-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 12207285-0 2002 Synthesis and acetylcholinesterase/butyrylcholinesterase inhibition activity of 4-amino-2, 3-diaryl-5, 6, 7, 8-tetrahydrofuro(and thieno)[2, 3-b]-quinolines, and 4-amino-5, 6, 7, 8, 9-pentahydro-2, 3-diphenylcyclohepta[e]furo(and thieno)-[2, 3-b]pyridines. thieno)[2, 3-b]-quinolines 130-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 12207285-0 2002 Synthesis and acetylcholinesterase/butyrylcholinesterase inhibition activity of 4-amino-2, 3-diaryl-5, 6, 7, 8-tetrahydrofuro(and thieno)[2, 3-b]-quinolines, and 4-amino-5, 6, 7, 8, 9-pentahydro-2, 3-diphenylcyclohepta[e]furo(and thieno)-[2, 3-b]pyridines. 4-amino-5, 6, 7, 8, 9-pentahydro-2, 3-diphenylcyclohepta[e]furo( 162-226 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 12207285-0 2002 Synthesis and acetylcholinesterase/butyrylcholinesterase inhibition activity of 4-amino-2, 3-diaryl-5, 6, 7, 8-tetrahydrofuro(and thieno)[2, 3-b]-quinolines, and 4-amino-5, 6, 7, 8, 9-pentahydro-2, 3-diphenylcyclohepta[e]furo(and thieno)-[2, 3-b]pyridines. thieno(2,3-b)pyridine 230-255 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 12207285-3 2002 These compounds are competitive inhibitors for acetylcholinesterase, the more potent being compound (13) which is three-fold less active than tacrine. Tacrine 142-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 12177686-3 2002 It is a reversible, competitive inhibitor of acetylcholinesterase (AChE), and is the only drug actively marketed for the treatment of AD with proven activity as an allosteric modulator of nicotinic acetylcholine receptors (nAChRs). Acetylcholine 45-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 12109912-11 2002 Finally, all the diamine diamides investigated in this study were much less potent in inhibiting AChE activity than prototype 3, suggesting that a macrocyclic structure may not be suitable for AChE inhibition. diamine diamides 17-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 12182861-1 2002 A series benzylpiperidinium and benzylpyridinium quaternary salts have been synthesised and tested for inhibition of acetylcholinesterase and reversal of neuromuscular block induced by vecuronium. benzylpiperidinium and benzylpyridinium quaternary salts 9-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 12195322-8 2002 The edrophonium test (short acting inhibitor of acetylcholinesterase) was positive (elevation of the ptotic lid after injection of edrophonium). Edrophonium 4-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 12111443-2 2002 This multiple-dose study has examined the relationship between inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities in the cerebrospinal fluid (CSF) and cognitive change (measured by the Computerised Neuropsychological Test Battery [CNTB]) following administration of the ChE inhibitor, rivastigmine (Exelon). Rivastigmine 321-333 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 12111443-2 2002 This multiple-dose study has examined the relationship between inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities in the cerebrospinal fluid (CSF) and cognitive change (measured by the Computerised Neuropsychological Test Battery [CNTB]) following administration of the ChE inhibitor, rivastigmine (Exelon). Rivastigmine 321-333 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 12111443-2 2002 This multiple-dose study has examined the relationship between inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities in the cerebrospinal fluid (CSF) and cognitive change (measured by the Computerised Neuropsychological Test Battery [CNTB]) following administration of the ChE inhibitor, rivastigmine (Exelon). Rivastigmine 335-341 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 12111443-2 2002 This multiple-dose study has examined the relationship between inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities in the cerebrospinal fluid (CSF) and cognitive change (measured by the Computerised Neuropsychological Test Battery [CNTB]) following administration of the ChE inhibitor, rivastigmine (Exelon). Rivastigmine 335-341 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 12094012-2 2002 It was established that this enzyme activity is acetylcholinesterase by substrate specificity (acetylthiocholine, acetyl-beta-methylthiocholine>propionylthiocholine>butyrylthiocholine), substrate inhibition, and specificity of inhibitors (BW284c51>iso-OMPA). Acetylthiocholine 95-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 12094012-2 2002 It was established that this enzyme activity is acetylcholinesterase by substrate specificity (acetylthiocholine, acetyl-beta-methylthiocholine>propionylthiocholine>butyrylthiocholine), substrate inhibition, and specificity of inhibitors (BW284c51>iso-OMPA). acetyl-beta-(methylthio)choline 114-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 12094012-2 2002 It was established that this enzyme activity is acetylcholinesterase by substrate specificity (acetylthiocholine, acetyl-beta-methylthiocholine>propionylthiocholine>butyrylthiocholine), substrate inhibition, and specificity of inhibitors (BW284c51>iso-OMPA). propionylthiocholine 147-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 12094012-2 2002 It was established that this enzyme activity is acetylcholinesterase by substrate specificity (acetylthiocholine, acetyl-beta-methylthiocholine>propionylthiocholine>butyrylthiocholine), substrate inhibition, and specificity of inhibitors (BW284c51>iso-OMPA). Butyrylthiocholine 171-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 12094012-2 2002 It was established that this enzyme activity is acetylcholinesterase by substrate specificity (acetylthiocholine, acetyl-beta-methylthiocholine>propionylthiocholine>butyrylthiocholine), substrate inhibition, and specificity of inhibitors (BW284c51>iso-OMPA). Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide 245-253 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 12094012-2 2002 It was established that this enzyme activity is acetylcholinesterase by substrate specificity (acetylthiocholine, acetyl-beta-methylthiocholine>propionylthiocholine>butyrylthiocholine), substrate inhibition, and specificity of inhibitors (BW284c51>iso-OMPA). Tetraisopropylpyrophosphamide 257-265 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 12183113-2 2002 We tested several radiolabeled lipophilic acetylcholine analogs, e.g., N-methylpiperidyl esters, which readily entered the brain via the blood-brain barrier, were hydrolyzed selectively by AChE, and were then trapped in the brain. Acetylcholine 42-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-193 12183113-2 2002 We tested several radiolabeled lipophilic acetylcholine analogs, e.g., N-methylpiperidyl esters, which readily entered the brain via the blood-brain barrier, were hydrolyzed selectively by AChE, and were then trapped in the brain. n-methylpiperidyl esters 71-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-193 12112408-0 2002 PET imaging of brain acetylcholinesterase using [11C]CP-126,998, a brain selective enzyme inhibitor. Carbon-11 49-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 12112408-0 2002 PET imaging of brain acetylcholinesterase using [11C]CP-126,998, a brain selective enzyme inhibitor. CP 126,998 53-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 12112408-6 2002 The results of this study indicate that PET imaging of [(11)C]CP-126,998 may be useful in quantifying the distribution of regional brain AChE. cp-126 62-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 12195322-8 2002 The edrophonium test (short acting inhibitor of acetylcholinesterase) was positive (elevation of the ptotic lid after injection of edrophonium). Edrophonium 131-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 12044655-6 2002 However, analysis of salt-extractable AChE isoforms revealed an increase in the proportion of G(1) in both cortex and CSF, similar to that previously observed in AD patients. Salts 21-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 12134831-1 2002 An RP-HPLC study for the pKa determination of a series of basic compounds related to caproctamine, a dibenzylaminediamide reversible inhibitor of acetylcholinesterase, is reported. caproctamine 85-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-166 12134831-1 2002 An RP-HPLC study for the pKa determination of a series of basic compounds related to caproctamine, a dibenzylaminediamide reversible inhibitor of acetylcholinesterase, is reported. dibenzylaminediamide 101-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-166 12107655-9 2002 Peak AChE inhibition was maintained in hen brain up to 6 days after a single dose of isofenphos, suggesting prolonged pharmacokinetics. isofenphos 85-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 12244759-3 2002 RESULTS: Compared with the average values of every biochemical parameter in the HAV group, the average values of LPO in plasma and in erythrocytes, and NO in plasma in the AOPP group were significantly increased (P = 0.000001), while the average values of VC, VE, beta-CAR in plasma as well as SOD, CAT, GSH-Px and AChE in erythrocytes in the AOPP group were significantly decreased (P = 0.000001). 3-(2-aminooxyphenyl)propanoic acid 172-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 315-319 11959475-1 2002 In this study, acetylcholinesterase and choline oxidase were co-immobilized on poly(2-hydroxyethyl methacrylate) membranes and the change in oxygen consumption upon aldicarb introduction was measured. Polyhydroxyethyl Methacrylate 79-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 11959475-1 2002 In this study, acetylcholinesterase and choline oxidase were co-immobilized on poly(2-hydroxyethyl methacrylate) membranes and the change in oxygen consumption upon aldicarb introduction was measured. Oxygen 141-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 11959475-1 2002 In this study, acetylcholinesterase and choline oxidase were co-immobilized on poly(2-hydroxyethyl methacrylate) membranes and the change in oxygen consumption upon aldicarb introduction was measured. Aldicarb 165-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 12140604-0 2002 Galanthamine as bis-functional ligand for the acetylcholinesterase. Galantamine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 12139365-4 2002 The dual acetylcholinesterase/butyrylcholinesterase (AChE/BuChE) inhibitor rivastigmine was shown to have several potential advantages over the AChE-selective inhibitors donepezil and galantamine for the treatment of BPSD. Rivastigmine 75-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 12139365-4 2002 The dual acetylcholinesterase/butyrylcholinesterase (AChE/BuChE) inhibitor rivastigmine was shown to have several potential advantages over the AChE-selective inhibitors donepezil and galantamine for the treatment of BPSD. Rivastigmine 75-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 12139365-4 2002 The dual acetylcholinesterase/butyrylcholinesterase (AChE/BuChE) inhibitor rivastigmine was shown to have several potential advantages over the AChE-selective inhibitors donepezil and galantamine for the treatment of BPSD. Galantamine 184-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 12139365-9 2002 Dual inhibition of AChE and BuChE and brain-region selectivity through preferential inhibition of the G1 isoform of AChE may provide the underlying reasons for the apparently greater and broader efficacy of rivastigmine over AChE-selective inhibitors for the treatment of BPSD. Rivastigmine 207-219 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 12139365-9 2002 Dual inhibition of AChE and BuChE and brain-region selectivity through preferential inhibition of the G1 isoform of AChE may provide the underlying reasons for the apparently greater and broader efficacy of rivastigmine over AChE-selective inhibitors for the treatment of BPSD. Rivastigmine 207-219 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 12139365-9 2002 Dual inhibition of AChE and BuChE and brain-region selectivity through preferential inhibition of the G1 isoform of AChE may provide the underlying reasons for the apparently greater and broader efficacy of rivastigmine over AChE-selective inhibitors for the treatment of BPSD. Rivastigmine 207-219 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 12139366-2 2002 New research suggests that rivastigmine, a potent, pseudo-irreversible inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase that shows preferential selectivity for the G1 form of AChE, may provide symptomatic and disease progression slowing effects. Rivastigmine 27-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 12139366-2 2002 New research suggests that rivastigmine, a potent, pseudo-irreversible inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase that shows preferential selectivity for the G1 form of AChE, may provide symptomatic and disease progression slowing effects. Rivastigmine 27-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 12139366-2 2002 New research suggests that rivastigmine, a potent, pseudo-irreversible inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase that shows preferential selectivity for the G1 form of AChE, may provide symptomatic and disease progression slowing effects. Rivastigmine 27-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-202 12139367-3 2002 These events have been associated more with the dual acetylcholinesterase/butyrylcholinesterase (AChE/BuChE) inhibitor rivastigmine than with the AChE-selective inhibitors donepezil and galantamine, probably due to rivastigmine"s higher potency. Rivastigmine 119-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 12139367-3 2002 These events have been associated more with the dual acetylcholinesterase/butyrylcholinesterase (AChE/BuChE) inhibitor rivastigmine than with the AChE-selective inhibitors donepezil and galantamine, probably due to rivastigmine"s higher potency. Donepezil 172-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 12139368-4 2002 Tacrine and rivastigmine inhibit both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in the CSF of Alzheimer"s disease patients. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 12139368-4 2002 Tacrine and rivastigmine inhibit both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in the CSF of Alzheimer"s disease patients. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 12139368-4 2002 Tacrine and rivastigmine inhibit both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in the CSF of Alzheimer"s disease patients. Rivastigmine 12-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 12139368-4 2002 Tacrine and rivastigmine inhibit both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in the CSF of Alzheimer"s disease patients. Rivastigmine 12-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 12111443-7 2002 CSF samples were continuously collected together with plasma samples prior to and for 12 hours after the final dose of rivastigmine, and AChE and BuChE activities determined.AChE in CSF and BuChE in plasma were dose-dependently inhibited by rivastigmine treatment. Rivastigmine 119-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 12111443-7 2002 CSF samples were continuously collected together with plasma samples prior to and for 12 hours after the final dose of rivastigmine, and AChE and BuChE activities determined.AChE in CSF and BuChE in plasma were dose-dependently inhibited by rivastigmine treatment. Rivastigmine 241-253 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 12140604-1 2002 Acetylcholinesterase plays a key role in the development of Alzheimer"s disease as this enzyme is responsible for cleavage of the neurotransmitter acetylcholine, and, according to recent investigations, also promotes aggregation of beta-amyloid peptides, which causes plaque formation in synaptic areas. Acetylcholine 147-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 12140604-2 2002 We have performed a molecular modeling study to investigate bis-galanthamine derivatives connected by a methylene spacer of varying length as dual acting acetylcholinesterase ligands. bis-galanthamine 60-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-174 12009429-1 2002 This study examines the effect of the antidepressants fluoxetine, sertraline and amitriptyline on cholinesterase (acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE)) activities in human serum and erythrocyte membrane (ghost). Fluoxetine 54-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 12134305-6 2002 Up to now, although with limited success, this improvement has been achieved only with the reversible inhibitors of acetylcholinesterase tacrine, rivastigmine and donepezil, available in the clinic since a few years. Tacrine 137-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 12134305-6 2002 Up to now, although with limited success, this improvement has been achieved only with the reversible inhibitors of acetylcholinesterase tacrine, rivastigmine and donepezil, available in the clinic since a few years. Donepezil 163-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 12134305-7 2002 The last approved has been galantamine that in spite of being a modest inhibitor of acetylcholinesterase, improves memory (ADAS cog test) and slows down cognitive impairment of Alzheimer patients. Galantamine 27-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 12009429-1 2002 This study examines the effect of the antidepressants fluoxetine, sertraline and amitriptyline on cholinesterase (acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE)) activities in human serum and erythrocyte membrane (ghost). Sertraline 66-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 12009429-1 2002 This study examines the effect of the antidepressants fluoxetine, sertraline and amitriptyline on cholinesterase (acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE)) activities in human serum and erythrocyte membrane (ghost). Amitriptyline 81-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 12009429-6 2002 At the micromolar range concentration, sertraline (60-120 microM) and amitriptyline (60-180 microM) inhibited human erythrocyte AChE. Sertraline 39-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 12009429-6 2002 At the micromolar range concentration, sertraline (60-120 microM) and amitriptyline (60-180 microM) inhibited human erythrocyte AChE. Amitriptyline 70-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 11964254-0 2002 Properties of water molecules in the active site gorge of acetylcholinesterase from computer simulation. Water 14-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 11964163-0 2002 Overloading and removal of N-glycosylation targets on human acetylcholinesterase: effects on glycan composition and circulatory residence time. Nitrogen 27-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 11964163-0 2002 Overloading and removal of N-glycosylation targets on human acetylcholinesterase: effects on glycan composition and circulatory residence time. Polysaccharides 93-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 11964163-11 2002 This study provides evidence that glycan loading, together with N-glycan terminal processing and enzyme subunit oligomerization, operate in a hierarchical and concerted manner in determining the pharmacokinetic characteristics of AChE. Polysaccharides 34-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 230-234 11964163-11 2002 This study provides evidence that glycan loading, together with N-glycan terminal processing and enzyme subunit oligomerization, operate in a hierarchical and concerted manner in determining the pharmacokinetic characteristics of AChE. n-glycan 64-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 230-234 11888725-1 2002 The interaction of monosulfonate tetraphenyl porphine (TPPS(1)) with immobilized acetylcholinesterase (AChE) yields a characteristic absorbance peak at 446 nm. monosulfonate tetraphenyl porphine 19-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 11888725-1 2002 The interaction of monosulfonate tetraphenyl porphine (TPPS(1)) with immobilized acetylcholinesterase (AChE) yields a characteristic absorbance peak at 446 nm. monosulfonate tetraphenyl porphine 19-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 11888725-1 2002 The interaction of monosulfonate tetraphenyl porphine (TPPS(1)) with immobilized acetylcholinesterase (AChE) yields a characteristic absorbance peak at 446 nm. tetraphenylporphine sulfonate 55-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 11888725-1 2002 The interaction of monosulfonate tetraphenyl porphine (TPPS(1)) with immobilized acetylcholinesterase (AChE) yields a characteristic absorbance peak at 446 nm. tetraphenylporphine sulfonate 55-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 11888725-2 2002 Addition of acetylcholine iodide or the competitive inhibitor tetracaine to the immobilized TPPS(1)-AChE complex results in a decrease in absorbance intensity at 446 nm due to displacement of the porphyrin from the active site. Acetylcholine 12-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 11888725-2 2002 Addition of acetylcholine iodide or the competitive inhibitor tetracaine to the immobilized TPPS(1)-AChE complex results in a decrease in absorbance intensity at 446 nm due to displacement of the porphyrin from the active site. Tetracaine 62-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 12083745-0 2002 Research and development of donepezil hydrochloride, a new type of acetylcholinesterase inhibitor. Donepezil 28-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 12083745-8 2002 Donepezil showed several positive characteristics including the following: 1) It has a novel structure compared to other conventional ChE inhibitors; 2) It shows strong anti-AChE activity and has long lasting efficacy; 3) The inhibitory characteristic of donepezil shows that it is highly selective for AChE as compared to butyrylcholinesterase (BuChE) and showed reversibility; 4) The results of clinical studies on donepezil show a very high significant difference on ADAS cog and CIBIC plus scores of AD patients. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 12083745-8 2002 Donepezil showed several positive characteristics including the following: 1) It has a novel structure compared to other conventional ChE inhibitors; 2) It shows strong anti-AChE activity and has long lasting efficacy; 3) The inhibitory characteristic of donepezil shows that it is highly selective for AChE as compared to butyrylcholinesterase (BuChE) and showed reversibility; 4) The results of clinical studies on donepezil show a very high significant difference on ADAS cog and CIBIC plus scores of AD patients. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 303-307 12083745-8 2002 Donepezil showed several positive characteristics including the following: 1) It has a novel structure compared to other conventional ChE inhibitors; 2) It shows strong anti-AChE activity and has long lasting efficacy; 3) The inhibitory characteristic of donepezil shows that it is highly selective for AChE as compared to butyrylcholinesterase (BuChE) and showed reversibility; 4) The results of clinical studies on donepezil show a very high significant difference on ADAS cog and CIBIC plus scores of AD patients. Donepezil 255-264 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 12083745-8 2002 Donepezil showed several positive characteristics including the following: 1) It has a novel structure compared to other conventional ChE inhibitors; 2) It shows strong anti-AChE activity and has long lasting efficacy; 3) The inhibitory characteristic of donepezil shows that it is highly selective for AChE as compared to butyrylcholinesterase (BuChE) and showed reversibility; 4) The results of clinical studies on donepezil show a very high significant difference on ADAS cog and CIBIC plus scores of AD patients. Donepezil 255-264 acetylcholinesterase (Cartwright blood group) Homo sapiens 303-307 11964254-1 2002 A 10-ns trajectory from a molecular dynamics simulation is used to examine the structure and dynamics of water in the active site gorge of acetylcholinesterase to determine what influence water may have on its function. Water 105-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-159 11964254-1 2002 A 10-ns trajectory from a molecular dynamics simulation is used to examine the structure and dynamics of water in the active site gorge of acetylcholinesterase to determine what influence water may have on its function. Water 188-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-159 12138250-1 2002 Vertebrates possess two cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) which both hydrolyze acetylcholine, but differ in their specificity towards other substrates, and in their sensitivity to inhibitors. Acetylcholine 41-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 12138250-4 2002 AChE subunits of type H ("hydrophobic") produce GPI-anchored dimers, but also secreted molecules; they are mostly expressed in blood cells. Glycosylphosphatidylinositols 48-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 12164543-3 2002 Pretreatment of OP poisoning relies on the subchronic administration of the reversible acetylcholinesterase (AChE) inhibitor pyridostigmine (PYR). Pyridostigmine Bromide 125-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 12164543-3 2002 Pretreatment of OP poisoning relies on the subchronic administration of the reversible acetylcholinesterase (AChE) inhibitor pyridostigmine (PYR). Pyridostigmine Bromide 125-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 12164543-3 2002 Pretreatment of OP poisoning relies on the subchronic administration of the reversible acetylcholinesterase (AChE) inhibitor pyridostigmine (PYR). Pyridostigmine Bromide 141-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 12164543-3 2002 Pretreatment of OP poisoning relies on the subchronic administration of the reversible acetylcholinesterase (AChE) inhibitor pyridostigmine (PYR). Pyridostigmine Bromide 141-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 12164543-5 2002 Comparatively, huperzine (HUP) is a reversible AChE inhibitor that crosses the blood-brain barrier. huperzine A 15-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 11978898-2 2002 Standard treatment involves the administration of intravenous atropine and an oxime to counter acetylcholinesterase inhibition at the synapse, but the usefulness of oximes is uncertain. Oximes 78-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 12132693-0 2002 Alanine reverses the inhibitory effect of phenylalanine on acetylcholinesterase activity. Alanine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 12132693-1 2002 The aim of this work was to evaluate, in vitro, the effect of L-alanine (Ala) on suckling rat brain acetylcholinesterase (AChE) and on eel Electrophorus electricus pure AChE inhibited by L-phenylalanine (Phe) as well as to investigate whether Phe or Ala is a competitive inhibitor or an effector of the enzyme. Phenylalanine 187-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 12132693-1 2002 The aim of this work was to evaluate, in vitro, the effect of L-alanine (Ala) on suckling rat brain acetylcholinesterase (AChE) and on eel Electrophorus electricus pure AChE inhibited by L-phenylalanine (Phe) as well as to investigate whether Phe or Ala is a competitive inhibitor or an effector of the enzyme. Phenylalanine 204-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 12132693-1 2002 The aim of this work was to evaluate, in vitro, the effect of L-alanine (Ala) on suckling rat brain acetylcholinesterase (AChE) and on eel Electrophorus electricus pure AChE inhibited by L-phenylalanine (Phe) as well as to investigate whether Phe or Ala is a competitive inhibitor or an effector of the enzyme. Phenylalanine 243-246 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 12132693-1 2002 The aim of this work was to evaluate, in vitro, the effect of L-alanine (Ala) on suckling rat brain acetylcholinesterase (AChE) and on eel Electrophorus electricus pure AChE inhibited by L-phenylalanine (Phe) as well as to investigate whether Phe or Ala is a competitive inhibitor or an effector of the enzyme. Alanine 250-253 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 12132693-2 2002 AChE activity was determined in brain homogenates and in the pure enzyme after 1 h preincubation with 1.2 mM of Phe or Ala as well as with Phe plus Ala. Phenylalanine 112-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 12132693-2 2002 AChE activity was determined in brain homogenates and in the pure enzyme after 1 h preincubation with 1.2 mM of Phe or Ala as well as with Phe plus Ala. Alanine 119-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 12132693-3 2002 The activity of the pure AChE was also determined using as a substrate different amounts of acetylthiocholine. Acetylthiocholine 92-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 12132693-4 2002 Ala reversed completely the inhibited AChE by Phe (18-20% in 500-600 microM substrate, p<0.01). Alanine 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 12132693-4 2002 Ala reversed completely the inhibited AChE by Phe (18-20% in 500-600 microM substrate, p<0.01). Phenylalanine 46-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 18968616-1 2002 A screen-printed biosensor for the detection of pesticides in water miscible organic solvents is described based on the use of p-aminophenyl acetate as acetylcholinesterase substrate. Water 62-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 18968616-1 2002 A screen-printed biosensor for the detection of pesticides in water miscible organic solvents is described based on the use of p-aminophenyl acetate as acetylcholinesterase substrate. p-aminophenyl acetate 127-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 18968616-4 2002 The acetylcholinesterase (AChE) was immobilised on a screen-printed electrode surface by entrapment in a PVA-SbQ polymer and the catalytic activity of immobilised AChE was studied in the presence of different percentages of organic solvents in buffer solution. pva-sbq polymer 105-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 18968616-4 2002 The acetylcholinesterase (AChE) was immobilised on a screen-printed electrode surface by entrapment in a PVA-SbQ polymer and the catalytic activity of immobilised AChE was studied in the presence of different percentages of organic solvents in buffer solution. pva-sbq polymer 105-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 12027383-5 2002 Aliquots with added calcium (without the presence of Br-A23187 in DMSO) had a significantly higher erythrocyte acetylcholinesterase activity. Calcium 20-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 12027383-5 2002 Aliquots with added calcium (without the presence of Br-A23187 in DMSO) had a significantly higher erythrocyte acetylcholinesterase activity. Bromine 53-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 12027383-5 2002 Aliquots with added calcium (without the presence of Br-A23187 in DMSO) had a significantly higher erythrocyte acetylcholinesterase activity. Dimethyl Sulfoxide 66-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 11956509-0 2002 Cholinergic toxic syndrome by the anticancer drug irinotecan: acetylcholinesterase does not play a major role. Irinotecan 50-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 11956509-1 2002 BACKGROUND: The anticancer drug irinotecan induces cholinergic side effects that are currently ascribed to the blockade of acetylcholinesterase. Irinotecan 32-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-143 11956509-2 2002 This study investigated (1) the pattern of acetylcholinesterase activity in patients receiving treatment with irinotecan and (2) the relationship between acetylcholinesterase activity and plasma concentrations of irinotecan, 7-ethyl-10-hydroxycamptothecin (SN-38), and SN-38 glucuronide (SN-38G). Irinotecan 110-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 11956509-2 2002 This study investigated (1) the pattern of acetylcholinesterase activity in patients receiving treatment with irinotecan and (2) the relationship between acetylcholinesterase activity and plasma concentrations of irinotecan, 7-ethyl-10-hydroxycamptothecin (SN-38), and SN-38 glucuronide (SN-38G). Irinotecan 213-223 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-174 11956509-9 2002 In vitro, the activity of acetylcholinesterase was inhibited by 100-micromol/L irinotecan (-24.8%) and markedly reduced by 1-micromol/L physostigmine (-86.7%), whereas neither SN-38 nor camptothecin had an effect. Irinotecan 79-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 11956509-9 2002 In vitro, the activity of acetylcholinesterase was inhibited by 100-micromol/L irinotecan (-24.8%) and markedly reduced by 1-micromol/L physostigmine (-86.7%), whereas neither SN-38 nor camptothecin had an effect. Physostigmine 136-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 11956509-9 2002 In vitro, the activity of acetylcholinesterase was inhibited by 100-micromol/L irinotecan (-24.8%) and markedly reduced by 1-micromol/L physostigmine (-86.7%), whereas neither SN-38 nor camptothecin had an effect. Irinotecan 176-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 11956509-9 2002 In vitro, the activity of acetylcholinesterase was inhibited by 100-micromol/L irinotecan (-24.8%) and markedly reduced by 1-micromol/L physostigmine (-86.7%), whereas neither SN-38 nor camptothecin had an effect. Camptothecin 186-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 12099619-0 2002 Induction of oxidative stress and acetylcholinesterase inhibition in organophosphorous pesticide manufacturing workers. organophosphorous 69-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 12099619-5 2002 The reduction in activity of AChE correlated well with increased TBARS and decreased FRAP in OP formulators. Thiobarbituric Acid Reactive Substances 65-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 11904227-2 2002 To understand the mechanism of substrate inhibition, the pH dependence of acetylthiocholine hydrolysis by AChE was studied between pH 5 and 8. Acetylthiocholine 74-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 12034133-8 2002 Finally, tianeptine-fluoxetine coadministration had no effect on learning consolidation; nevertheless, administration of an acetylcholinesterase inhibitor, phenserine, potentiated subeffective tianeptine or fluoxetine doses. phenserine 156-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 12034133-8 2002 Finally, tianeptine-fluoxetine coadministration had no effect on learning consolidation; nevertheless, administration of an acetylcholinesterase inhibitor, phenserine, potentiated subeffective tianeptine or fluoxetine doses. tianeptine 193-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 12034133-8 2002 Finally, tianeptine-fluoxetine coadministration had no effect on learning consolidation; nevertheless, administration of an acetylcholinesterase inhibitor, phenserine, potentiated subeffective tianeptine or fluoxetine doses. Fluoxetine 207-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 12018828-3 2002 Rivastigmine is a potent inhibitor of AChE and BuChE and has demonstrated broad benefits across the severity of AD and across the cognitive, functional and behavioural domains of AD. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 12018828-5 2002 These benefits may reflect the inhibition of both AChE and BuChE, as demonstrated by significant correlations between cognitive improvements and cholinesterase inhibition in rivastigmine-treated patients with AD. Rivastigmine 174-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 12420757-0 2002 Sensitive detection of organophosphorus pesticides using a needle type amperometric acetylcholinesterase-based bioelectrode. organophosphorus 23-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 12420757-2 2002 An acetylcholinesterase (AChE) based amperometric bioelectrode for a selective detection of low concentrations of organophosphorus pesticides has been developed. organophosphorus 114-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 3-23 12420757-2 2002 An acetylcholinesterase (AChE) based amperometric bioelectrode for a selective detection of low concentrations of organophosphorus pesticides has been developed. organophosphorus 114-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 12420757-3 2002 The amperometric needle type bioelectrode consists of a bare cavity in a PTFE isolated Pt-Ir wire, where the AChE was entrapped into a photopolymerised polymer of polyvinyl alcohol bearing styrylpyridinium groups (PVA-SbQ). Polymers 140-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 12420757-3 2002 The amperometric needle type bioelectrode consists of a bare cavity in a PTFE isolated Pt-Ir wire, where the AChE was entrapped into a photopolymerised polymer of polyvinyl alcohol bearing styrylpyridinium groups (PVA-SbQ). styrylpyridinium 189-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 12420757-3 2002 The amperometric needle type bioelectrode consists of a bare cavity in a PTFE isolated Pt-Ir wire, where the AChE was entrapped into a photopolymerised polymer of polyvinyl alcohol bearing styrylpyridinium groups (PVA-SbQ). pva-sbq 214-221 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 12420757-4 2002 Cyclic voltammetry, performed at Pt and AChE/Pt disk electrodes, confirmed the irreversible, monoelectronic thiocholine oxidation process and showed that a working potential of +0.410 V vs. Ag/AgCl, KCl(sat) was suitable for a selective and sensitive amperometric detection of thiocholine. Thiocholine 108-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 12420757-4 2002 Cyclic voltammetry, performed at Pt and AChE/Pt disk electrodes, confirmed the irreversible, monoelectronic thiocholine oxidation process and showed that a working potential of +0.410 V vs. Ag/AgCl, KCl(sat) was suitable for a selective and sensitive amperometric detection of thiocholine. silver chloride 193-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 12420757-5 2002 The acetylthiocholine detection under enzyme kinetic control was found in the range of 0.01-0.3 U cm(-2) of immobilised AChE. Acetylthiocholine 4-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 11985878-4 2002 Our results first showed that in apoptotic SK-N-SH cells, AChE aggregated in the nucleus and suppression of AChE expression with antisense oligonucleotide could save the cells from apoptosis. Oligonucleotides 139-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 11985878-4 2002 Our results first showed that in apoptotic SK-N-SH cells, AChE aggregated in the nucleus and suppression of AChE expression with antisense oligonucleotide could save the cells from apoptosis. Oligonucleotides 139-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 11888271-1 2002 Rivastigmine, a carbamate inhibitor of acetylcholinesterase, is already in use for treatment of Alzheimer"s disease under the trade name of Exelon. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 11888271-1 2002 Rivastigmine, a carbamate inhibitor of acetylcholinesterase, is already in use for treatment of Alzheimer"s disease under the trade name of Exelon. Carbamates 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 11888271-1 2002 Rivastigmine, a carbamate inhibitor of acetylcholinesterase, is already in use for treatment of Alzheimer"s disease under the trade name of Exelon. Rivastigmine 140-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 11888271-2 2002 Rivastigmine carbamylates Torpedo californica acetylcholinesterase very slowly (k(i) = 2.0 M(-1) min(-1)), whereas the bimolecular rate constant for inhibition of human acetylcholinesterase is >1600-fold higher (k(i) = 3300 M(-1) min(-1)). Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 11888271-2 2002 Rivastigmine carbamylates Torpedo californica acetylcholinesterase very slowly (k(i) = 2.0 M(-1) min(-1)), whereas the bimolecular rate constant for inhibition of human acetylcholinesterase is >1600-fold higher (k(i) = 3300 M(-1) min(-1)). Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-189 11888271-4 2002 Spontaneous reactivation of all four conjugates is very slow, with <10% reactivation being observed for the Torpedo enzyme after 48 h. The crystal structure of the conjugate of rivastigmine with Torpedo acetylcholinesterase was determined to 2.2 A resolution. Rivastigmine 180-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 206-226 11863435-1 2002 Huprine X is a novel acetylcholinesterase (AChE) inhibitor, with one of the highest affinities reported for a reversible inhibitor. huprine X 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 11863435-2 2002 It is a synthetic hybrid that contains the 4-aminoquinoline substructure of one anti-Alzheimer drug, tacrine, and a carbobicyclic moiety resembling that of another AChE inhibitor, (-)-huperzine A. huperzine A 180-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 11863435-3 2002 Cocrystallization of huprine X with Torpedo californica AChE yielded crystals whose 3D structure was determined to 2.1 A resolution. huprine X 21-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 11863435-7 2002 Steady-state inhibition data show that huprine X binds to human AChE and Torpedo AChE 28- and 54-fold, respectively, more tightly than tacrine. huprine 39-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 11863435-7 2002 Steady-state inhibition data show that huprine X binds to human AChE and Torpedo AChE 28- and 54-fold, respectively, more tightly than tacrine. huprine 39-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 11863435-9 2002 Furthermore, both tacrine and huprine X bind more tightly to Torpedo than to human AChE, suggesting that their quinoline substructures interact better with Phe330 than with Tyr337, the corresponding residue in the human AChE structure. Tacrine 18-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 11863435-9 2002 Furthermore, both tacrine and huprine X bind more tightly to Torpedo than to human AChE, suggesting that their quinoline substructures interact better with Phe330 than with Tyr337, the corresponding residue in the human AChE structure. Tacrine 18-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 220-224 11863435-9 2002 Furthermore, both tacrine and huprine X bind more tightly to Torpedo than to human AChE, suggesting that their quinoline substructures interact better with Phe330 than with Tyr337, the corresponding residue in the human AChE structure. huprine 30-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 11863435-9 2002 Furthermore, both tacrine and huprine X bind more tightly to Torpedo than to human AChE, suggesting that their quinoline substructures interact better with Phe330 than with Tyr337, the corresponding residue in the human AChE structure. huprine 30-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 220-224 11863435-9 2002 Furthermore, both tacrine and huprine X bind more tightly to Torpedo than to human AChE, suggesting that their quinoline substructures interact better with Phe330 than with Tyr337, the corresponding residue in the human AChE structure. quinoline 111-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 11863435-9 2002 Furthermore, both tacrine and huprine X bind more tightly to Torpedo than to human AChE, suggesting that their quinoline substructures interact better with Phe330 than with Tyr337, the corresponding residue in the human AChE structure. quinoline 111-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 220-224 11888054-0 2002 Determination of donepezil, an acetylcholinesterase inhibitor, in human plasma by high-performance liquid chromatography with ultraviolet absorbance detection. Donepezil 17-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 11929041-1 2002 In central nervous system, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) hydrolyse acetylcholine. Acetylcholine 27-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 11846640-4 2002 Most nonoccupational illnesses resulting from entry into areas treated with chlorpyrifos likely stem from odor, rather than the ability of the organophosphate to inhibit AChE. Organophosphates 143-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 11805735-4 2002 The standard treatment consists of reactivation of the inhibited acetylcholinesterase with an oxime antidote and reversal of the biochemical effects of acetylcholine with atropine. Oximes 94-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 11755352-1 2002 A series of oxyanilinium-based AChE inhibitors have been synthesised and tested for the reversal of vecuronium-induced neuromuscular block. oxyanilinium 12-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 11755352-1 2002 A series of oxyanilinium-based AChE inhibitors have been synthesised and tested for the reversal of vecuronium-induced neuromuscular block. Vecuronium Bromide 100-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 11799248-3 2002 Corticosterone, anticholinesterases, and forced swim, each facilitated a rapid (minutes), yet long-lasting (weeks), shift from AChE-S to the normally rare AChE-R mRNA, promoted AChE-R mRNA translocation into neurites, and induced enzyme secretion. Corticosterone 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 11799248-3 2002 Corticosterone, anticholinesterases, and forced swim, each facilitated a rapid (minutes), yet long-lasting (weeks), shift from AChE-S to the normally rare AChE-R mRNA, promoted AChE-R mRNA translocation into neurites, and induced enzyme secretion. Corticosterone 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 11799248-3 2002 Corticosterone, anticholinesterases, and forced swim, each facilitated a rapid (minutes), yet long-lasting (weeks), shift from AChE-S to the normally rare AChE-R mRNA, promoted AChE-R mRNA translocation into neurites, and induced enzyme secretion. Corticosterone 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 11936097-5 2002 The disposable AChE-biosensor was directly applied in solvent extracts of food samples using isooctane as extraction solvent. 2,2,4-trimethylpentane 93-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 11824541-0 2002 (+)-Alpha-viniferin, a stilbene trimer from Caragana chamlague, inhibits acetylcholinesterase. alpha-viniferin 0-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 11824541-0 2002 (+)-Alpha-viniferin, a stilbene trimer from Caragana chamlague, inhibits acetylcholinesterase. Stilbenes 23-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 11824541-1 2002 In the course of screening natural products for anti-acetylcholinesterase (AChE) activity, we found that a total methanolic extract of the underground parts of Caragana chamlague (Leguminosae) had significant inhibition towards AChE. methanolic 113-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-73 11824541-1 2002 In the course of screening natural products for anti-acetylcholinesterase (AChE) activity, we found that a total methanolic extract of the underground parts of Caragana chamlague (Leguminosae) had significant inhibition towards AChE. methanolic 113-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 11824541-1 2002 In the course of screening natural products for anti-acetylcholinesterase (AChE) activity, we found that a total methanolic extract of the underground parts of Caragana chamlague (Leguminosae) had significant inhibition towards AChE. methanolic 113-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 228-232 11852291-0 2002 Therapeutic effects of an acetylcholinesterase inhibitor (donepezil) on memory in Wernicke-Korsakoff"s disease. Donepezil 58-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 11904227-8 2002 Thus a single amino acid substitution in the pi-cation site, from the aromatic tyrosine of B. fasciatus AChE to the alanine of BuChE, caused AChE to behave like BuChE. Tyrosine 79-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 11904227-8 2002 Thus a single amino acid substitution in the pi-cation site, from the aromatic tyrosine of B. fasciatus AChE to the alanine of BuChE, caused AChE to behave like BuChE. Tyrosine 79-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 11904227-8 2002 Thus a single amino acid substitution in the pi-cation site, from the aromatic tyrosine of B. fasciatus AChE to the alanine of BuChE, caused AChE to behave like BuChE. Alanine 116-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 11904227-8 2002 Thus a single amino acid substitution in the pi-cation site, from the aromatic tyrosine of B. fasciatus AChE to the alanine of BuChE, caused AChE to behave like BuChE. Alanine 116-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 12082257-11 2002 The activity of three enzymes was measured (acetylcholinesterase - Ache, dehydrogenase glucoso-6-phosphate - G-6-PD and gluthatione reductase - GR) for both bfl and TCDD-treated RBC. buflomedil 157-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 11904227-9 2002 Excess substrate binds to the peripheral anionic site (PAS) of AChE. Aminosalicylic Acid 55-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 12082257-11 2002 The activity of three enzymes was measured (acetylcholinesterase - Ache, dehydrogenase glucoso-6-phosphate - G-6-PD and gluthatione reductase - GR) for both bfl and TCDD-treated RBC. buflomedil 157-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 11904227-10 2002 The finding that AChE is activated by excess substrate supports the idea that binding of a second substrate molecule to the PAS induces a conformational change that reorganizes the active site. Aminosalicylic Acid 124-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 12082257-11 2002 The activity of three enzymes was measured (acetylcholinesterase - Ache, dehydrogenase glucoso-6-phosphate - G-6-PD and gluthatione reductase - GR) for both bfl and TCDD-treated RBC. Polychlorinated Dibenzodioxins 165-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 12162759-10 2002 Tacrine and rivastigmine inhibit both enzymes, whereas donepezil and galantamine specifically inhibit AChE. Donepezil 55-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 12082257-11 2002 The activity of three enzymes was measured (acetylcholinesterase - Ache, dehydrogenase glucoso-6-phosphate - G-6-PD and gluthatione reductase - GR) for both bfl and TCDD-treated RBC. Polychlorinated Dibenzodioxins 165-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 12162759-10 2002 Tacrine and rivastigmine inhibit both enzymes, whereas donepezil and galantamine specifically inhibit AChE. Galantamine 69-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 12481195-5 2002 Galantamine modestly inhibits acetylcholinesterase and has an allosteric potentiating ligand effect at nicotinic receptors. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 12481195-6 2002 The data collected in this review suggest that the unique combination of acetylcholinesterase inhibition and nicotinic acetylcholine receptor modulation offers potentially significant benefits over acetylcholinesterase inhibition alone in facilitating acetylcholine neurotransmission. Acetylcholine 73-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-218 12481195-6 2002 The data collected in this review suggest that the unique combination of acetylcholinesterase inhibition and nicotinic acetylcholine receptor modulation offers potentially significant benefits over acetylcholinesterase inhibition alone in facilitating acetylcholine neurotransmission. Acetylcholine 119-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-218 12094822-2 2002 Donepezil is a specific, reversible inhibitor of AChE, while rivastigmine is a slowly reversible (pseudoirreversible) dual cholinesterase (ChE) inhibitor, with brain-regional specificity for the cerebral cortex and hippocampus. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 12240787-4 2002 Here, we present a case series of patients with Parkinson"s disease and dementia who we treated with rivastigmine, a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) that shows brain region-selectivity. Rivastigmine 101-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 12240787-4 2002 Here, we present a case series of patients with Parkinson"s disease and dementia who we treated with rivastigmine, a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) that shows brain region-selectivity. Rivastigmine 101-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 12240787-6 2002 Rivastigmine was well tolerated by our patients when the dose was escalated slowly, including one patient who had previously experienced severe side-effects with the AChE-selective inhibitor donepezil. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 12240787-6 2002 Rivastigmine was well tolerated by our patients when the dose was escalated slowly, including one patient who had previously experienced severe side-effects with the AChE-selective inhibitor donepezil. Donepezil 191-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 12636178-12 2002 Rivastigmine robustly inhibits butyrylcholinesterase in addition to AChE and therefore acts as a dual ChE inhibitor. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 12636181-1 2002 Acetylcholinesterase (AChE) predominates in the healthy brain, with butyrylcholinesterase (BuChE) considered to play a minor role in regulating brain acetylcholine (ACh) levels. Acetylcholine 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 12636181-5 2002 Experimental evidence from the use of agents with enhanced selectivity for BuChE (cymserine analogues, MF-8622) and the dual inhibitor of both AChE and BuChE, rivastigmine, indicates potential therapeutic benefits of inhibiting both AChE and BuChE in AD and related dementias. Rivastigmine 159-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 12636181-5 2002 Experimental evidence from the use of agents with enhanced selectivity for BuChE (cymserine analogues, MF-8622) and the dual inhibitor of both AChE and BuChE, rivastigmine, indicates potential therapeutic benefits of inhibiting both AChE and BuChE in AD and related dementias. Rivastigmine 159-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-237 11979423-0 2002 Inhibition of acetylcholinesterase by physostigmine analogs: conformational mobility of cysteine loop due to the steric effect of the alkyl chain. Physostigmine 38-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 11852665-10 2002 All, including Tabun, Sarin, Soman, and VX, are organophosphates that inactivate acetylcholinesterase. Organophosphates 48-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 11979423-0 2002 Inhibition of acetylcholinesterase by physostigmine analogs: conformational mobility of cysteine loop due to the steric effect of the alkyl chain. Cysteine 88-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 11979423-1 2002 The effect of a series of physostigmine analogs on acetylcholinesterase activity was investigated. Physostigmine 26-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 11756485-7 2002 With ionotropic glutamate transmission blocked, inhibition of AChE increased spontaneous EPSP frequency and amplitude, suggesting spontaneous ACh release. Glutamic Acid 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 12456061-1 2002 Current Alzheimer"s disease therapies suppress acetylcholine hydrolysis by inhibiting acetylcholinesterase (AChE) at cholinergic synapses. Acetylcholine 47-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 12507060-0 2002 Serum acetylcholinesterase and prognosis of acute organophosphate poisoning. Organophosphates 50-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-26 12507060-1 2002 OBJECTIVE: The aim of this study is to investigate the prognostic value of serum acetylcholinesterase levels and their relationship with neurological syndromes (Type 1 syndrome, intermediate syndrome, and delayed polyneuropathy) in acute organophosphate poisoning. Organophosphates 238-253 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 12507060-10 2002 CONCLUSION: In the acute phase of organophosphate poisoning, low serum acetylcholinesterase (> 50% of minimum normal value) supports the diagnosis of organophosphate poisoning but it does not show a significant relationship to the severity of poisoning (NS). Organophosphates 34-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 12507060-10 2002 CONCLUSION: In the acute phase of organophosphate poisoning, low serum acetylcholinesterase (> 50% of minimum normal value) supports the diagnosis of organophosphate poisoning but it does not show a significant relationship to the severity of poisoning (NS). Organophosphates 153-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 12507060-11 2002 The serum acetylcholinesterase activity may be a useful parameter in following the acute prognosis of organophosphate poisoning. Organophosphates 102-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-30 11926533-7 2002 b) In the hippocampus, inhibition of AChE by Phe could lead to problems in memory, while Na+,K+-ATPase inhibition by Phe may induce metabolic disorders and electrical instability of the synaptosomal membrane. Phenylalanine 45-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 12031351-2 2002 Only monomeric acetylcholinesterase, a form of acetylcholinesterase dominant in development, increased neurite outgrowth (3-10 U/ml); moreover this effect was not blocked by active site blockers (echothiophate and galanthamine) but was sensitive to the addition of peripheral site blockers (fasciculin and BW284c51). Galantamine 214-226 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 12031351-2 2002 Only monomeric acetylcholinesterase, a form of acetylcholinesterase dominant in development, increased neurite outgrowth (3-10 U/ml); moreover this effect was not blocked by active site blockers (echothiophate and galanthamine) but was sensitive to the addition of peripheral site blockers (fasciculin and BW284c51). Galantamine 214-226 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 12031351-5 2002 Acetylcholinesterase regulation of outgrowth was shown to depend on an influx of extracellular calcium specifically via the L-type voltage-gated calcium channel. Calcium 95-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 11926533-6 2002 It is suggested that: a) In the frontal cortex, the improper acetylcholine (ACh) release, due to AChE inhibition by Phe, combined with the stimulation of Na+,K+-ATPase, possibly explain tremor and the hyperkinetic behaviour in patients with classical phenylketonuria (PKU). Acetylcholine 61-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 11926533-6 2002 It is suggested that: a) In the frontal cortex, the improper acetylcholine (ACh) release, due to AChE inhibition by Phe, combined with the stimulation of Na+,K+-ATPase, possibly explain tremor and the hyperkinetic behaviour in patients with classical phenylketonuria (PKU). Acetylcholine 76-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 11926533-6 2002 It is suggested that: a) In the frontal cortex, the improper acetylcholine (ACh) release, due to AChE inhibition by Phe, combined with the stimulation of Na+,K+-ATPase, possibly explain tremor and the hyperkinetic behaviour in patients with classical phenylketonuria (PKU). Phenylalanine 116-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 11755146-1 2001 The effect of huperzine A, a reversible and selective acetylcholinesterase inhibitor, on reserpine- or yohimbine-induced spatial working memory deficits in monkeys has been examined using the delayed response task that depends on the integrity of prefrontal cortex. huperzine A 14-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 11831902-3 2002 Therefore, a new series of compounds named pyridophens were designed and synthesized to achieve binary prodrugs to preferentially inhibit AChE over BChE, while still retaining the muscarinic receptor antagonism of aprophen. pyridophens 43-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 11831902-5 2002 Three compounds, 9 (a tertiary pyridine), 10 (a quaternary pyridine), and 12 (a tertiary tetrahydropyridine), were found to be effective inhibitors of both BChE and AChE. tertiary 22-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 11831902-5 2002 Three compounds, 9 (a tertiary pyridine), 10 (a quaternary pyridine), and 12 (a tertiary tetrahydropyridine), were found to be effective inhibitors of both BChE and AChE. pyridine 31-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 11831902-5 2002 Three compounds, 9 (a tertiary pyridine), 10 (a quaternary pyridine), and 12 (a tertiary tetrahydropyridine), were found to be effective inhibitors of both BChE and AChE. quaternary pyridine 48-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 11831902-5 2002 Three compounds, 9 (a tertiary pyridine), 10 (a quaternary pyridine), and 12 (a tertiary tetrahydropyridine), were found to be effective inhibitors of both BChE and AChE. Pyrrolidines 89-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 11831902-6 2002 However, 10, N-methyl-3-[[(dimethylamino)carbonyl]oxy]-2-(2"2"-diphenylpropionoxy-methyl)pyridinium iodide, inhibited AChE selectively over BChE, with a bimolecular rate constant similar to pyridostigmine. 10, n-methyl-3-[[(dimethylamino)carbonyl]oxy]-2-(2"2"-diphenylpropionoxy-methyl)pyridinium iodide, 9-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 11553882-1 2001 This study addressed whether methacrylate monomers and polymers used in dentistry might degrade from enzymolysis by acetylcholinesterase (ACHE), cholesterol esterase (CHE), porcine liver esterase (PRLE), and a pancreatic lipase (PNL). Methacrylates 29-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 11553882-1 2001 This study addressed whether methacrylate monomers and polymers used in dentistry might degrade from enzymolysis by acetylcholinesterase (ACHE), cholesterol esterase (CHE), porcine liver esterase (PRLE), and a pancreatic lipase (PNL). Methacrylates 29-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 11553882-6 2001 The K(m) for triethylene glycol dimethacrylate (TEGDMA) was 197 microM for ACHE and 1107 microM for CHE. triethylene glycol dimethacrylate 13-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 11553882-6 2001 The K(m) for triethylene glycol dimethacrylate (TEGDMA) was 197 microM for ACHE and 1107 microM for CHE. triethylene glycol dimethacrylate 48-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 11782241-2 2001 OBJECTIVE: To assess the clinical and cognitive effects of adding donepezil, a reversible acetylcholinesterase inhibitor, to the risperidone treatment of a high functioning stable out-patient with schizophrenia. Donepezil 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 11679273-1 2001 The fiber-optic biosensor consisting of an acetylcholinesterase (AChE)-immobilized Langmuir-Blodgett (LB) film was developed to detect organophosphorus compounds in contaminated water. Organophosphorus Compounds 135-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 11679273-1 2001 The fiber-optic biosensor consisting of an acetylcholinesterase (AChE)-immobilized Langmuir-Blodgett (LB) film was developed to detect organophosphorus compounds in contaminated water. Water 178-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 11679273-2 2001 The sensing scheme was based on the decrease of yellow product, o-nitrophenol, from a colorless substrate, o-nitrophenyl acetate, due to the inhibition by organophosphorus compounds on AChE. 2-nitrophenol 64-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 185-189 11679273-2 2001 The sensing scheme was based on the decrease of yellow product, o-nitrophenol, from a colorless substrate, o-nitrophenyl acetate, due to the inhibition by organophosphorus compounds on AChE. 2-NITROPHENYL ACETATE 107-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 185-189 11679273-2 2001 The sensing scheme was based on the decrease of yellow product, o-nitrophenol, from a colorless substrate, o-nitrophenyl acetate, due to the inhibition by organophosphorus compounds on AChE. organophosphorus 155-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 185-189 11679273-5 2001 AChE-immobilized LB film was formed by adsorbing the enzyme molecules onto a viologen monolayer using the electrostatic force. lb 17-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 11679273-6 2001 The proposed kinetics for irreversible inhibition of organophosphorus compounds on AChE agreed well with the experimental data. organophosphorus 53-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 11825333-1 2001 Galantamine is a newly available cholinergic drug that offsets reductions in central cholinergic neurotransmission in Alzheimer"s disease (AD) by specifically and reversibly inhibiting acetylcholinesterase (AChE) and by allosterically modulating nicotinic cholinergic receptors. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 185-205 11825333-1 2001 Galantamine is a newly available cholinergic drug that offsets reductions in central cholinergic neurotransmission in Alzheimer"s disease (AD) by specifically and reversibly inhibiting acetylcholinesterase (AChE) and by allosterically modulating nicotinic cholinergic receptors. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-211 11966199-0 2002 [Inhibition by various alkaloids of acetylcholinesterase and butyrylcholinesterase from human blood]. Alkaloids 23-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-82 11689088-1 2001 The design, synthesis, and rapid evaluation of a new class of acetylcholinesterase (AChE) inhibitors related to donepezil are reported. Donepezil 112-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 11708910-4 2001 An analysis of the structure/anticholinesterase activity relationship of the described compounds, together with molecular modeling, confirmed the catalytic triad mechanism of the binding of this class of carabamate analogues within AChE and BChE and defined structural requirements for their differential inhibition. carabamate 204-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 232-236 11689088-1 2001 The design, synthesis, and rapid evaluation of a new class of acetylcholinesterase (AChE) inhibitors related to donepezil are reported. Donepezil 112-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 11689088-2 2001 A molecular dynamics simulation of the complex between AChE and one representative compound of the series showed a possible inhibitor binding mode in which favorable interactions are formed between the benzylpiperidinone moiety and some active-site residues. benzylpiperidinone 202-220 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 19811027-3 2001 In vitro and in vivo studies have confirmed that galantamine is an orally-active, reversible, competitive inhibitor of brain cholinesterase, which is 50 times more selective for acetylcholinesterase, compared with butyrylcholinesterase. Galantamine 49-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-198 11589922-0 2001 Cerebrospinal fluid acetylcholinesterase activity after long-term treatment with donepezil and rivastigmina. Donepezil 81-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 11589922-0 2001 Cerebrospinal fluid acetylcholinesterase activity after long-term treatment with donepezil and rivastigmina. rivastigmina 95-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 11589922-2 2001 This study was designed to assess the effects of 6-12 month treatment with AChEIs donepezil and rivastigmine on cerebrospinal fluid (CSF) AChE and butyrylcholinesterase (BuChE) activity in AD patients. Donepezil 82-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 11589922-4 2001 In AD patients treated with donepezil a significant increase of CFS AChE activity was observed, whereas treatment with rivastigmine induced a significant decrease of AChE activity. Donepezil 28-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 11454976-8 2001 One membrane was perfused with the acetylcholinesterase inhibitor neostigmine, while the other was perfused with the vehicle. Neostigmine 66-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 11689067-0 2001 Acetylcholinesterase inhibitors: SAR and kinetic studies on omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl derivatives. omega-[n-methyl-n-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl derivatives 60-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 11689067-5 2001 Some new omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl analogues were designed, synthesized, and evaluated for their inhibitory activity against both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). omega-[n-methyl-n-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl 9-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-192 11689067-5 2001 Some new omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl analogues were designed, synthesized, and evaluated for their inhibitory activity against both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). omega-[n-methyl-n-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl 9-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 194-198 11568364-5 2001 While mammalian acetylcholinesterase activity has often been determined in tissue homogenates in the presence of the nondenaturing detergent Triton X-100 at a concentration of 1%, the potential actions of this detergent on the activity of this critical enzyme are not understood. Octoxynol 141-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 11568366-1 2001 Neurotoxic organophosphorous compounds are known to modulate their biological effects through the inhibition of a number of esterases including acetylcholinesterase (AChE), the enzyme responsible for the degradation of the neurotransmitter acetylcholine. organophosphorous 11-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-164 11568366-1 2001 Neurotoxic organophosphorous compounds are known to modulate their biological effects through the inhibition of a number of esterases including acetylcholinesterase (AChE), the enzyme responsible for the degradation of the neurotransmitter acetylcholine. organophosphorous 11-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 11568366-1 2001 Neurotoxic organophosphorous compounds are known to modulate their biological effects through the inhibition of a number of esterases including acetylcholinesterase (AChE), the enzyme responsible for the degradation of the neurotransmitter acetylcholine. Acetylcholine 144-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 11568366-5 2001 Our models can be useful in screening databases of organophosphorous compounds for their neurotoxicity potential via the inhibition of acetylcholinesterase. organophosphorous 51-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 11553037-0 2001 Insulin-like effect of (-)epicatechin on erythrocyte membrane acetylcholinesterase activity in type 2 diabetes mellitus. Catechin 23-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 11553037-7 2001 In the present study, the in vitro effect of (-)epicatechin and/or insulin was tested on erythrocyte membrane AChE in normal and type 2 diabetic patients. Catechin 45-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 11553037-8 2001 The aim of the study was to test the efficacy of (-)epicatechin to mimic insulin in its effect on erythrocyte membrane AChE. Catechin 49-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 11553037-11 2001 Epicatechin (1 mmol/L) also caused an elevation in AChE activity in diabetic erythrocytes, an effect that was similar to the effect of insulin. Catechin 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 11553037-13 2001 Epicatechin has a pronounced insulin-like effect on erythrocyte membrane-bound AChE in type 2 diabetic patients; however, the mechanism of action of epicatechin remains speculative. Catechin 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 19811047-3 2001 The three new acetylcholinesterase inhibitors licensed to treat Alzheimer"s disease (donepezil, rivastigmine and galantamine) have provided clinicians with a major impetus to their desire to diagnose and treat this lethal disease. Donepezil 85-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 19811047-3 2001 The three new acetylcholinesterase inhibitors licensed to treat Alzheimer"s disease (donepezil, rivastigmine and galantamine) have provided clinicians with a major impetus to their desire to diagnose and treat this lethal disease. Rivastigmine 96-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 19811047-3 2001 The three new acetylcholinesterase inhibitors licensed to treat Alzheimer"s disease (donepezil, rivastigmine and galantamine) have provided clinicians with a major impetus to their desire to diagnose and treat this lethal disease. Galantamine 113-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 11495583-1 2001 Starting from the 3-[2-(1-benzylpiperidin-4-yl)ethylamino]-6-phenylpyridazine 1, we performed the design, the synthesis, and the structure-activity relationships of a series of pyridazine analogues acting as AChE inhibitors. 3-(2-(1-benzylpiperidin-4-yl)ethylamino)-6-phenylpyridazine 18-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-212 11495583-2 2001 Structural modifications were achieved on four different parts of compound 1 and led to the following observations: (i) introduction of a lipophilic environment in the C-5 position of the pyridazine ring is favorable for the AChE-inhibitory activity and the AChE/BuChE selectivity; (ii) substitution and various replacements of the C-6 phenyl group are possible and led to equivalent or slightly more active derivatives; (iii) isosteric replacements or modifications of the benzylpiperidine moiety are detrimental to the activity. pyridazine 188-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 225-229 11495583-2 2001 Structural modifications were achieved on four different parts of compound 1 and led to the following observations: (i) introduction of a lipophilic environment in the C-5 position of the pyridazine ring is favorable for the AChE-inhibitory activity and the AChE/BuChE selectivity; (ii) substitution and various replacements of the C-6 phenyl group are possible and led to equivalent or slightly more active derivatives; (iii) isosteric replacements or modifications of the benzylpiperidine moiety are detrimental to the activity. pyridazine 188-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 258-262 11495583-3 2001 Among all derivatives prepared, the indenopyridazine derivative 4g was found to be the more potent inhibitor with an IC(50) of 10 nM on electric eel AChE. indenopyridazine 36-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 11495583-5 2001 Moreover, 3-[2-(1-benzylpiperidin-4-yl)ethylamino]-5-methyl-6-phenylpyridazine 4c, which showed an IC(50) of 21 nM, is 100-times more selective for human AChE (human BuChE/AChE ratio of 24) than the reference compound tacrine. 3-(2-(1-benzylpiperidin-4-yl)--ethylamino)-5-methyl-6-phenylpyridazine 10-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-158 11495583-5 2001 Moreover, 3-[2-(1-benzylpiperidin-4-yl)ethylamino]-5-methyl-6-phenylpyridazine 4c, which showed an IC(50) of 21 nM, is 100-times more selective for human AChE (human BuChE/AChE ratio of 24) than the reference compound tacrine. 3-(2-(1-benzylpiperidin-4-yl)--ethylamino)-5-methyl-6-phenylpyridazine 10-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-176 11495583-5 2001 Moreover, 3-[2-(1-benzylpiperidin-4-yl)ethylamino]-5-methyl-6-phenylpyridazine 4c, which showed an IC(50) of 21 nM, is 100-times more selective for human AChE (human BuChE/AChE ratio of 24) than the reference compound tacrine. Tacrine 218-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-158 11495583-5 2001 Moreover, 3-[2-(1-benzylpiperidin-4-yl)ethylamino]-5-methyl-6-phenylpyridazine 4c, which showed an IC(50) of 21 nM, is 100-times more selective for human AChE (human BuChE/AChE ratio of 24) than the reference compound tacrine. Tacrine 218-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-176 11719866-4 2001 In the present study, we propose a new rapid variation of AChE staining which avoids the use of DAB and naphthol, notably toxic reagents, but follows the same acceleration principle of Kobayashi"s technique. 3,3'-Diaminobenzidine 96-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 11719866-4 2001 In the present study, we propose a new rapid variation of AChE staining which avoids the use of DAB and naphthol, notably toxic reagents, but follows the same acceleration principle of Kobayashi"s technique. Naphthols 104-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 11719866-8 2001 Rapid AChE was performed with a special incubation medium using 3-amino-9 ethylcarbazole (AEC) as chromogenic substance. 3-amino-9-ethylcarbazole 64-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 11719866-8 2001 Rapid AChE was performed with a special incubation medium using 3-amino-9 ethylcarbazole (AEC) as chromogenic substance. 3-amino-9-ethylcarbazole 90-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 11719866-14 2001 This new rapid AChE histochemical technique avoids the use of DAB and naphthol, and can thus be considered safe for operators. 3,3'-Diaminobenzidine 62-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 11719866-14 2001 This new rapid AChE histochemical technique avoids the use of DAB and naphthol, and can thus be considered safe for operators. Naphthols 70-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 11719866-15 2001 Rapid AChE is a valid tool for both the evaluation of aganglionosis extension and for the identification of IND pattern during surgery. indole 108-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 11563919-1 2001 Chimeras of tacrine and m-(N,N,N-Trimethylammonio)trifluoroacetophenone (1) were designed as novel, reversible inhibitors of acetylcholinesterase. Tacrine 12-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 11563919-1 2001 Chimeras of tacrine and m-(N,N,N-Trimethylammonio)trifluoroacetophenone (1) were designed as novel, reversible inhibitors of acetylcholinesterase. m-(N,N,N-trimethylammonio)trifluoroacetophenone 24-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 11543689-0 2001 Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase. Coumarins 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 11523986-2 2001 We have shown that AChE interacts with the amyloid beta-peptide (Abeta) and promotes amyloid fibril formation by a hydrophobic environment close to the peripheral anionic binding site (PAS) of the enzyme. Aminosalicylic Acid 185-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 11520028-8 2001 The cholinesterase inhibitor methyl paraoxon significantly decreased AChE staining intensity. methylparaoxon 29-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 11571763-2 2001 BACKGROUND: Galantamine is a reversible, competitive, selective inhibitor of acetylcholinesterase (AChE) that also allosterically modulates nicotinic acetylcholine receptors. Galantamine 12-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 11571763-2 2001 BACKGROUND: Galantamine is a reversible, competitive, selective inhibitor of acetylcholinesterase (AChE) that also allosterically modulates nicotinic acetylcholine receptors. Acetylcholine 77-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 12369972-3 2001 This is illustrated in the case of the recently reported huprines, which are a new class of very potent and selective acetylcholinesterase inhibitors. huprines 57-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 12049482-0 2001 The inhibition of acetylcholinesterase by irinotecan and related camptothecins: key structural properties and experimental variables. Irinotecan 42-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 12049482-0 2001 The inhibition of acetylcholinesterase by irinotecan and related camptothecins: key structural properties and experimental variables. Camptothecin 65-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 12049482-2 2001 Recently, we demonstrated that CPT-11 (lactone) is also a potent inhibitor of human acetylcholinesterase (AChE) at clinically relevant concentrations. Irinotecan 31-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 12049482-2 2001 Recently, we demonstrated that CPT-11 (lactone) is also a potent inhibitor of human acetylcholinesterase (AChE) at clinically relevant concentrations. Irinotecan 31-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 12049482-2 2001 Recently, we demonstrated that CPT-11 (lactone) is also a potent inhibitor of human acetylcholinesterase (AChE) at clinically relevant concentrations. Lactones 39-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 12049482-2 2001 Recently, we demonstrated that CPT-11 (lactone) is also a potent inhibitor of human acetylcholinesterase (AChE) at clinically relevant concentrations. Lactones 39-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 12049482-3 2001 Attachment of heterocyclic and branched amino groups onto the camptothecin back-bone continues to be a strategy for the synthesis of water-soluble analogues, but this may lead to undesirable inhibition of AChE. Camptothecin 62-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 205-209 12049482-4 2001 In this study, we screened a range of camptothecin analogues, degradation products and metabolites for their ability to inhibit AChE. Camptothecin 38-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 12049482-5 2001 Those compounds possessing N-substitutions at C-10 were all found to inhibit AChE in a similar kinetic manner to CPT-11, but with a broad range of potencies. Irinotecan 113-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 12049482-10 2001 Overall, our experiments reveal that nitrogenous substitutions at the permissive C-10 of the camptothecin backbone may lead to AchE inhibition, particularly if they involve a quaternary nitrogen. Camptothecin 93-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 12049482-10 2001 Overall, our experiments reveal that nitrogenous substitutions at the permissive C-10 of the camptothecin backbone may lead to AchE inhibition, particularly if they involve a quaternary nitrogen. Nitrogen 37-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 11463350-0 2001 Effect of chemical modification of recombinant human acetylcholinesterase by polyethylene glycol on its circulatory longevity. Polyethylene Glycols 77-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 11577800-0 2001 Acetylcholinesterase inhibition and the extrapyramidal syndrome: a review of the neurotoxicity of organophosphate. Organophosphates 98-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 11577800-2 2001 Acute cholinergic crisis caused by the inhibition of synaptic acetylcholinesterase is the major manifestation of organophosphate poisoning and may cause death within minutes. Organophosphates 113-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 11453726-2 2001 Recent kinetic and mass spectral data demonstrated that a difference in mechanism of inactivation exists for AChE treated with (1R)- versus (1S,3S)-stereoisomers. (1r 127-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 11453739-1 2001 Understanding reaction pathways of phosphylation, reactivation, and "aging" of AChE with toxic organophosphate compounds is both a biochemical and a pharmacological challenge. Organophosphates 95-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 11453726-2 2001 Recent kinetic and mass spectral data demonstrated that a difference in mechanism of inactivation exists for AChE treated with (1R)- versus (1S,3S)-stereoisomers. Caffeine 140-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 11453739-2 2001 Here we describe experiments which allowed to resolve some of the less well understood reaction pathways of phosphylation and "aging" of acetylcholinesterase (AChE) involving phosphoroamidates (P-N agents) such as tabun or the widely used pesticide methamidophos. phosphoroamidates 175-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 11453739-2 2001 Here we describe experiments which allowed to resolve some of the less well understood reaction pathways of phosphylation and "aging" of acetylcholinesterase (AChE) involving phosphoroamidates (P-N agents) such as tabun or the widely used pesticide methamidophos. phosphoroamidates 175-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 11453726-13 2001 Furthermore, the results suggest that the mechanistic shift demonstrated to occur for inhibition of AChE by (1R)- versus (1S,3S)-isomers is conserved for butyrylcholinesterase and cholesterol esterase. (1r) 108-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 11453739-2 2001 Here we describe experiments which allowed to resolve some of the less well understood reaction pathways of phosphylation and "aging" of acetylcholinesterase (AChE) involving phosphoroamidates (P-N agents) such as tabun or the widely used pesticide methamidophos. methamidophos 249-262 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 11453739-2 2001 Here we describe experiments which allowed to resolve some of the less well understood reaction pathways of phosphylation and "aging" of acetylcholinesterase (AChE) involving phosphoroamidates (P-N agents) such as tabun or the widely used pesticide methamidophos. methamidophos 249-262 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 11453726-13 2001 Furthermore, the results suggest that the mechanistic shift demonstrated to occur for inhibition of AChE by (1R)- versus (1S,3S)-isomers is conserved for butyrylcholinesterase and cholesterol esterase. Caffeine 121-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 19003327-5 2001 However, incubating the cells with the alkylphenols for 24 hr significantly inhibited acetylcholinesterase activity at concentrations as low as 0.8 muM, with n-octylphenol showing the most significant effect Since it is believed that human exposure to nonylphenol from drinking water is around 0.7 mug day(-1) and that these compounds can accumulate in adipose tissue, this finding may implicate alkylphenols in neurological and behavioral disturbances in both animals and humans. alkylphenols 39-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 19003327-5 2001 However, incubating the cells with the alkylphenols for 24 hr significantly inhibited acetylcholinesterase activity at concentrations as low as 0.8 muM, with n-octylphenol showing the most significant effect Since it is believed that human exposure to nonylphenol from drinking water is around 0.7 mug day(-1) and that these compounds can accumulate in adipose tissue, this finding may implicate alkylphenols in neurological and behavioral disturbances in both animals and humans. n-octylphenol 158-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 11690566-3 2001 Inhibition of acetylcholinesterase was greater in cells treated for 28 days with all active organophosphorus compounds than it was in cells treated only once with the same concentration of a given OP compound. organophosphorus 92-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 11690566-4 2001 The protoxicants chlorpyrifos and parathion produced acetylcholinesterase inhibition after multiple exposures although no inhibition was seen following a single exposure to these agents. Chlorpyrifos 17-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 11690566-4 2001 The protoxicants chlorpyrifos and parathion produced acetylcholinesterase inhibition after multiple exposures although no inhibition was seen following a single exposure to these agents. Parathion 34-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 11508499-5 2001 There was a statistically significant relationship between ACE activity and the levels of primary oxidation products in the RBC of patients with AD before and after treatment with amiridine and gliatiline. amiridine 180-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-62 11669505-2 2001 Currently, cholinergic deficit is usually corrected by increasing the amount of acetylcholine in the synapse by inhibiting acetylcholinesterase (AChE). Acetylcholine 80-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-143 11669505-2 2001 Currently, cholinergic deficit is usually corrected by increasing the amount of acetylcholine in the synapse by inhibiting acetylcholinesterase (AChE). Acetylcholine 80-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 11669505-10 2001 In addition to increasing nAChR activity, galantamine also inhibits AChE. Galantamine 42-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 11669505-11 2001 This novel, dual mechanism of action distinguishes galantamine from many other AChE inhibitors. Galantamine 51-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 11669506-6 2001 Galantamine appears to be novel among marketed agents in that it inhibits AChE and modulates cholinergic nicotinic receptors, perhaps increasing neurotransmission via both mechanisms. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 11669506-8 2001 Conventional AChE inhibitors (rivastigmine and donepezil) have maintained ADAS-cog baseline scores for up to 40 weeks in open extension studies, and Mini-Mental State Examination (MMSE) scores for up to 52 weeks in a placebo-controlled study. Rivastigmine 30-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 11669506-8 2001 Conventional AChE inhibitors (rivastigmine and donepezil) have maintained ADAS-cog baseline scores for up to 40 weeks in open extension studies, and Mini-Mental State Examination (MMSE) scores for up to 52 weeks in a placebo-controlled study. Donepezil 47-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 12369981-0 2001 Tacrine-huperzine A hybrids (huprines): a new class of highly potent and selective acetylcholinesterase inhibitors of interest for the treatment of Alzheimer"s disease. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 12369981-0 2001 Tacrine-huperzine A hybrids (huprines): a new class of highly potent and selective acetylcholinesterase inhibitors of interest for the treatment of Alzheimer"s disease. huperzine A 8-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 12369981-0 2001 Tacrine-huperzine A hybrids (huprines): a new class of highly potent and selective acetylcholinesterase inhibitors of interest for the treatment of Alzheimer"s disease. huprines 29-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 12369981-1 2001 Tacrine-huperzine A hybrids (huprines) are a new class of very potent and selective acetylcholinesterase (AChE) inhibitors. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 12369981-1 2001 Tacrine-huperzine A hybrids (huprines) are a new class of very potent and selective acetylcholinesterase (AChE) inhibitors. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 12369981-1 2001 Tacrine-huperzine A hybrids (huprines) are a new class of very potent and selective acetylcholinesterase (AChE) inhibitors. huperzine A 8-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 12369981-1 2001 Tacrine-huperzine A hybrids (huprines) are a new class of very potent and selective acetylcholinesterase (AChE) inhibitors. huperzine A 8-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 12369981-1 2001 Tacrine-huperzine A hybrids (huprines) are a new class of very potent and selective acetylcholinesterase (AChE) inhibitors. huprines 29-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 12369981-1 2001 Tacrine-huperzine A hybrids (huprines) are a new class of very potent and selective acetylcholinesterase (AChE) inhibitors. huprines 29-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 12369981-4 2001 Structural variations on several parts of a lead structure have allowed to complete a structure-activity relationship exploration of this new structural family and have led to several huprines more active than other known AChE inhibitors. huprines 184-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 222-226 11681789-2 2001 In line with previous studies, the release of AChE (exovesicles) from HS erythrocytes during glucose-starvation was significantly higher (11%) compared to that from control erythrocytes (1%). Glucose 93-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 11508499-5 2001 There was a statistically significant relationship between ACE activity and the levels of primary oxidation products in the RBC of patients with AD before and after treatment with amiridine and gliatiline. gliatiline 194-204 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-62 11313335-0 2001 Thioflavin T is a fluorescent probe of the acetylcholinesterase peripheral site that reveals conformational interactions between the peripheral and acylation sites. thioflavin T 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 11313335-5 2001 Here we report that thioflavin T, a fluorophore widely used to detect amyloid structure in proteins, binds selectively to the AChE peripheral site with an equilibrium dissociation constant of 1.0 microm. thioflavin T 20-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 11313335-6 2001 The fluorescence of the bound thioflavin T is increased more than 1000-fold over that of unbound thioflavin T, the greatest enhancement of fluorescence for the binding of a fluorophore to AChE yet observed. thioflavin T 30-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-192 11313335-6 2001 The fluorescence of the bound thioflavin T is increased more than 1000-fold over that of unbound thioflavin T, the greatest enhancement of fluorescence for the binding of a fluorophore to AChE yet observed. thioflavin T 97-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-192 11313335-7 2001 Furthermore, when the acylation site ligands edrophonium or m-(N, N,N-trimethylammonio)trifluoroacetophenone form ternary complexes with AChE and thioflavin T, the fluorescence is quenched by factors of 2.7-4.2. Edrophonium 45-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 11313335-7 2001 Furthermore, when the acylation site ligands edrophonium or m-(N, N,N-trimethylammonio)trifluoroacetophenone form ternary complexes with AChE and thioflavin T, the fluorescence is quenched by factors of 2.7-4.2. m-(N,N,N-trimethylammonio)trifluoroacetophenone 60-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 11313335-8 2001 The observation of this partial quenching of thioflavin T fluorescence is a major advance in the study of AChE for two reasons. thioflavin T 45-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 11313335-10 2001 Second, it indicates that ligand binding to the acylation site initiates a change in the local AChE conformation at the peripheral site that quenches the fluorescence of bound thioflavin T. thioflavin T 176-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 11412096-0 2001 Does "butyrylization" of acetylcholinesterase through substitution of the six divergent aromatic amino acids in the active center gorge generate an enzyme mimic of butyrylcholinesterase? Amino Acids, Aromatic 88-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 11569538-2 2001 Acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BuChE, EC 3.1.1.8) are enzymes that catalyze the hydrolysis of esters of choline. Esters 130-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 11441435-2 2001 OBJECTIVE: The present study aimed to examine the effects of globally increasing cholinergic function with the acetylcholinesterase inhibitor donepezil on inspection time. Donepezil 142-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 11457659-4 2001 Acetylcholinesterase activity showed a significant increase, in comparison with controls, after treatment of the cells for 7 days with 0.1 or 1 microM 9-cis retinoic acid, alone or combined with 10 nM 1,25(OH)(2)D(3) or 10 nM KH 1060 or 10 nM EB 1089. Alitretinoin 151-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 11457659-4 2001 Acetylcholinesterase activity showed a significant increase, in comparison with controls, after treatment of the cells for 7 days with 0.1 or 1 microM 9-cis retinoic acid, alone or combined with 10 nM 1,25(OH)(2)D(3) or 10 nM KH 1060 or 10 nM EB 1089. ethylbenzene 243-245 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 11341833-0 2001 Short, strong hydrogen bonds at the active site of human acetylcholinesterase: proton NMR studies. Hydrogen 14-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 11341833-12 2001 However, the order of magnitude greater precision of the NMR-derived distances establishes the presence of SSHBs at the active site of acetylcholinesterase, and detect conformational heterogeneity of the active-site histidine. sshbs 107-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 11334569-1 2001 Eleven A-ring modified hexacyclic analogues of camptothecin (CPT) containing a 1,4-oxazine ring were synthesized from 10-hydroxycamptothecin (11a) and 7-ethyl-10-hydroxycamptothecin (3) (SN-38) in four to five steps and were subjected to the biological tests such as cytotoxicity, topoisomerase I (Topo I) inhibitory activity, acetylcholinesterase (AChE) inhibition, and stability in human plasma. Camptothecin 47-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 327-347 11453739-5 2001 We further show that the aging product of paraoxon-AChE adduct is identical to the aging product of the tabun-AChE conjugate. Paraoxon 42-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 11453739-7 2001 For methamidophos, we show that phosphylation of AChE involves elimination of the thiomethyl moiety and that the spontaneous reactivation of the resulting organophosphate adduct generates the phosphorus free AChE active site Ser-peptide. methamidophos 4-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 11453739-7 2001 For methamidophos, we show that phosphylation of AChE involves elimination of the thiomethyl moiety and that the spontaneous reactivation of the resulting organophosphate adduct generates the phosphorus free AChE active site Ser-peptide. methamidophos 4-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-212 11453739-7 2001 For methamidophos, we show that phosphylation of AChE involves elimination of the thiomethyl moiety and that the spontaneous reactivation of the resulting organophosphate adduct generates the phosphorus free AChE active site Ser-peptide. thiomethyl 82-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 11453739-7 2001 For methamidophos, we show that phosphylation of AChE involves elimination of the thiomethyl moiety and that the spontaneous reactivation of the resulting organophosphate adduct generates the phosphorus free AChE active site Ser-peptide. Organophosphates 155-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-212 11453739-7 2001 For methamidophos, we show that phosphylation of AChE involves elimination of the thiomethyl moiety and that the spontaneous reactivation of the resulting organophosphate adduct generates the phosphorus free AChE active site Ser-peptide. Phosphorus 192-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-212 11453739-7 2001 For methamidophos, we show that phosphylation of AChE involves elimination of the thiomethyl moiety and that the spontaneous reactivation of the resulting organophosphate adduct generates the phosphorus free AChE active site Ser-peptide. Serine 225-228 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-212 11334569-1 2001 Eleven A-ring modified hexacyclic analogues of camptothecin (CPT) containing a 1,4-oxazine ring were synthesized from 10-hydroxycamptothecin (11a) and 7-ethyl-10-hydroxycamptothecin (3) (SN-38) in four to five steps and were subjected to the biological tests such as cytotoxicity, topoisomerase I (Topo I) inhibitory activity, acetylcholinesterase (AChE) inhibition, and stability in human plasma. Camptothecin 47-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 349-353 11334569-1 2001 Eleven A-ring modified hexacyclic analogues of camptothecin (CPT) containing a 1,4-oxazine ring were synthesized from 10-hydroxycamptothecin (11a) and 7-ethyl-10-hydroxycamptothecin (3) (SN-38) in four to five steps and were subjected to the biological tests such as cytotoxicity, topoisomerase I (Topo I) inhibitory activity, acetylcholinesterase (AChE) inhibition, and stability in human plasma. Camptothecin 61-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 327-347 11334569-1 2001 Eleven A-ring modified hexacyclic analogues of camptothecin (CPT) containing a 1,4-oxazine ring were synthesized from 10-hydroxycamptothecin (11a) and 7-ethyl-10-hydroxycamptothecin (3) (SN-38) in four to five steps and were subjected to the biological tests such as cytotoxicity, topoisomerase I (Topo I) inhibitory activity, acetylcholinesterase (AChE) inhibition, and stability in human plasma. Camptothecin 61-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 349-353 11350858-4 2001 The stimulation of AChE synthesis induced by CGRP was mimicked by direct activation of AC with 3 - 30 microM forskolin. Colforsin 109-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 11708144-0 2001 Flow-injection spectrophotometric determination of paraoxon by its inhibitory effect on the enzyme acetylcholinesterase. Paraoxon 51-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 11708144-2 2001 The method was based on the determination of the acetic acid formed by the enzymatic reaction of the acetylcholinesterase, immobilized on glass beads, with the substrate acetylcholine. Acetic Acid 49-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 11350858-7 2001 These findings indicate that, in skeletal muscle cells, CGRP modulates the AChE expression in a time-dependent manner, initially stimulating the enzyme synthesis through a cyclic AMP-dependent mechanism. Cyclic AMP 172-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 11303072-7 2001 The reactivation time of HI-6 on soman-inhibited AChE was 6 +/- 2 min. asoxime chloride 25-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 11394735-2 2001 Initial use was made of four X-ray structures of AChE complexed with small, non-specific inhibitors to create a model of the binding of recently developed aminopyridazine derivatives. aminopyridazine 155-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 11394735-10 2001 After performing our modelling study the X-ray structure of AChE complexed with donepezil, an inhibitor structurally related to the developed aminopyirdazines, has been made available. Donepezil 80-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 11394735-10 2001 After performing our modelling study the X-ray structure of AChE complexed with donepezil, an inhibitor structurally related to the developed aminopyirdazines, has been made available. aminopyirdazines 142-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 11313435-5 2001 When the solution contained 10 microM neostigmine (NEO) 3000 stimuli reduced [integral]MEPCs by 60 %, because with acetylcholinesterase (AChE) inhibited, [integral]MEPC size is more sensitive to changes in acetylcholine (ACh) content. Neostigmine 38-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 11313435-5 2001 When the solution contained 10 microM neostigmine (NEO) 3000 stimuli reduced [integral]MEPCs by 60 %, because with acetylcholinesterase (AChE) inhibited, [integral]MEPC size is more sensitive to changes in acetylcholine (ACh) content. Neostigmine 38-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 11313435-5 2001 When the solution contained 10 microM neostigmine (NEO) 3000 stimuli reduced [integral]MEPCs by 60 %, because with acetylcholinesterase (AChE) inhibited, [integral]MEPC size is more sensitive to changes in acetylcholine (ACh) content. Neostigmine 51-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 11313435-5 2001 When the solution contained 10 microM neostigmine (NEO) 3000 stimuli reduced [integral]MEPCs by 60 %, because with acetylcholinesterase (AChE) inhibited, [integral]MEPC size is more sensitive to changes in acetylcholine (ACh) content. Neostigmine 51-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 11313435-5 2001 When the solution contained 10 microM neostigmine (NEO) 3000 stimuli reduced [integral]MEPCs by 60 %, because with acetylcholinesterase (AChE) inhibited, [integral]MEPC size is more sensitive to changes in acetylcholine (ACh) content. Acetylcholine 115-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 11329588-6 2001 The diagnosis of IND was based on the presence of hyperganglionosis of the submucous plexus and giant ganglia and at least one of the following features in rectal biopsies: (1) ectopic ganglia, (2) increased acetylcholinesterase (AChE) activity in the lamina propria, and (3) increased AChE nerve fibers around the submucosal blood vessels. indole 17-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-228 11329588-6 2001 The diagnosis of IND was based on the presence of hyperganglionosis of the submucous plexus and giant ganglia and at least one of the following features in rectal biopsies: (1) ectopic ganglia, (2) increased acetylcholinesterase (AChE) activity in the lamina propria, and (3) increased AChE nerve fibers around the submucosal blood vessels. indole 17-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 230-234 11329588-6 2001 The diagnosis of IND was based on the presence of hyperganglionosis of the submucous plexus and giant ganglia and at least one of the following features in rectal biopsies: (1) ectopic ganglia, (2) increased acetylcholinesterase (AChE) activity in the lamina propria, and (3) increased AChE nerve fibers around the submucosal blood vessels. indole 17-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 286-290 11369163-1 2001 Donepezil, an oral acetylcholinesterase inhibitor approved for the treatment of Alzheimer"s disease, was given to 6 cancer pain patients having sedation related to the analgesic use of opioids. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 11358251-0 2001 Screening for acetylcholinesterase inhibitors from Amaryllidaceae using silica gel thin-layer chromatography in combination with bioactivity staining. Silica Gel 72-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 11358251-2 2001 The TLC plate was developed and then stained using Ellman"s reagent, 5,5"-dithiobis-(2-nitrobenzoic acid), to detect acetylcholinesterase activity. Dithionitrobenzoic Acid 69-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 11334332-1 2001 Obidoxime is an antidote approved for reactivation of inhibited acetylcholinesterase in organophosphate poisoning. Obidoxime Chloride 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 11334332-1 2001 Obidoxime is an antidote approved for reactivation of inhibited acetylcholinesterase in organophosphate poisoning. Organophosphates 88-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 11336614-1 2001 Rivastigmine (Exelontrade mark, Novartis) is a novel intermediate-acting reversible and non-competitive carbamate acetylcholinesterase (AChE) that was recently introduced for the treatment of Alzheimer"s disease (AD). Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 11336614-1 2001 Rivastigmine (Exelontrade mark, Novartis) is a novel intermediate-acting reversible and non-competitive carbamate acetylcholinesterase (AChE) that was recently introduced for the treatment of Alzheimer"s disease (AD). Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 11336614-1 2001 Rivastigmine (Exelontrade mark, Novartis) is a novel intermediate-acting reversible and non-competitive carbamate acetylcholinesterase (AChE) that was recently introduced for the treatment of Alzheimer"s disease (AD). Carbamates 104-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 11336614-1 2001 Rivastigmine (Exelontrade mark, Novartis) is a novel intermediate-acting reversible and non-competitive carbamate acetylcholinesterase (AChE) that was recently introduced for the treatment of Alzheimer"s disease (AD). Carbamates 104-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 11426664-0 2001 Convergent synthesis of arisugacin skeletons and their acetylcholinesterase inhibitory activity. arisugacin 24-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 11303072-7 2001 The reactivation time of HI-6 on soman-inhibited AChE was 6 +/- 2 min. Soman 33-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 11299326-0 2001 Compensatory mechanisms enhance hippocampal acetylcholine release in transgenic mice expressing human acetylcholinesterase. Acetylcholine 44-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 11312608-0 2001 The cyclic AMP-mediated expression of acetylcholinesterase in myotubes shows contrasting activation and repression between avian and mammalian enzymes. Cyclic AMP 4-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 11312608-2 2001 We provide several lines of evidence to suggest that the cAMP-mediated AChE expression in myotube is oppositely regulated between avian and mammalian enzymes. Cyclic AMP 57-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 11312608-4 2001 Application of cAMP and forskolin induced the expression of chick AChE but reduced human AChE promoter-driven luciferase activity. Cyclic AMP 15-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 11312608-4 2001 Application of cAMP and forskolin induced the expression of chick AChE but reduced human AChE promoter-driven luciferase activity. Colforsin 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 11283752-1 2001 The discovery of the first neurotransmitter--acetylcholine--was soon followed by the discovery of its hydrolysing enzyme, acetylcholinesterase. Acetylcholine 45-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 11259791-3 2001 Rabbit anti-narcine AChE polyclonal antibodies were purified by Protein A-Sepharose CL 4B column chromatography. narcine 12-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 11259791-5 2001 Seven of 11 antigenic synthetic decapeptides of human brain AChE showed obvious immunoreactivity with the rabbit anti-narcine AChE polyclonal antibodies. narcine 118-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 11259791-5 2001 Seven of 11 antigenic synthetic decapeptides of human brain AChE showed obvious immunoreactivity with the rabbit anti-narcine AChE polyclonal antibodies. narcine 118-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 11226635-3 2001 However, CSF-AChE was significantly increased after treatment of AD patients with AChE inhibitors (donepezil and galantamine). Donepezil 99-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 11226635-3 2001 However, CSF-AChE was significantly increased after treatment of AD patients with AChE inhibitors (donepezil and galantamine). Galantamine 113-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 11255446-1 2001 BACKGROUND: Donepezil hydrochloride is a selective acetylcholinesterase inhibitor approved for the symptomatic treatment of mild to moderately severe Alzheimer disease (AD). Donepezil 12-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 11310608-0 2001 Synthesis and acetylcholinesterase/butyrylcholinesterase inhibition activity of new tacrine-like analogues. Tacrine 84-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 11370299-2 2001 Disposable biosensors, based on acetylcholinesterase inhibition activity, were exploited for testing the presence of organophosphorus and carbamate pesticides in water, fruit, and vegetable samples. organophosphorus 117-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 11370299-2 2001 Disposable biosensors, based on acetylcholinesterase inhibition activity, were exploited for testing the presence of organophosphorus and carbamate pesticides in water, fruit, and vegetable samples. Carbamates 138-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 11310608-1 2001 The synthesis and preliminary results for acetylcholinesterase and butyrylcholinesterase inhibition activity of a series of pyrano[2,3-b]quinolines (2, 3) and benzonaphthyridines (5, 6) derivatives are described. pyrano[2,3-b]quinolines 124-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 11310608-1 2001 The synthesis and preliminary results for acetylcholinesterase and butyrylcholinesterase inhibition activity of a series of pyrano[2,3-b]quinolines (2, 3) and benzonaphthyridines (5, 6) derivatives are described. benzonaphthyridines 159-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 11295884-0 2001 Positron emission tomographic measurement of brain acetylcholinesterase activity using N-[(11)C]methylpiperidin-4-yl acetate without arterial blood sampling: methodology of shape analysis and its diagnostic power for Alzheimer"s disease. N-methylpiperidin-4-yl acetate 87-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 11181580-2 2001 Because ACh is rapidly hydrolyzed by acetylcholinesterase (AChE), it is possible that AChE contributes to the modulation of SR. Acetylcholine 8-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 11181580-2 2001 Because ACh is rapidly hydrolyzed by acetylcholinesterase (AChE), it is possible that AChE contributes to the modulation of SR. Acetylcholine 8-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 11181580-2 2001 Because ACh is rapidly hydrolyzed by acetylcholinesterase (AChE), it is possible that AChE contributes to the modulation of SR. Acetylcholine 8-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 11181580-5 2001 One probe was perfused with the AChE inhibitor neostigmine (10 microM); the adjacent membrane was perfused with the vehicle (Ringer solution). Neostigmine 47-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 11295884-1 2001 N-[11C]methylpiperidin-4-yl acetate ([11C]MP4A) is a radiotracer that has been used successfully for the quantitative measurement of acetylcholinesterase (AChE) activity in the human brain with positron emission tomography (PET) using a standard compartment model analysis and a metabolite-corrected arterial input function. N-methylpiperidin-4-yl acetate 0-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 11295884-1 2001 N-[11C]methylpiperidin-4-yl acetate ([11C]MP4A) is a radiotracer that has been used successfully for the quantitative measurement of acetylcholinesterase (AChE) activity in the human brain with positron emission tomography (PET) using a standard compartment model analysis and a metabolite-corrected arterial input function. N-methylpiperidin-4-yl acetate 0-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 11295884-11 2001 However, taking its simplicity and noninvasiveness into account, the authors conclude that quantitative measurement of neocortical AChE activity with shape analysis and [11C]MP4A PET is practical and useful for clinical diagnosis of AD. Carbon-11 170-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 11226748-2 2001 The present study indicates that in the elderly, donepezil, an acetylcholinesterase inhibitor, also exerts a marked effect on REM sleep parameters--percentage of REM sleep and REM density were increased whereas REM latency was reduced. Donepezil 49-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 11230880-2 2001 Galantamine is a novel treatment for Alzheimer"s disease that inhibits acetylcholinesterase and modulates nicotinic receptors. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 11171913-0 2001 Effect of donepezil on brain acetylcholinesterase activity in patients with AD measured by PET. Donepezil 10-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 11171913-1 2001 Acetylcholinesterase (AChE) activities in the brain of three patients with AD were measured once before and once during donepezil treatment (5 mg/d in two patients, 3 mg/d in one patient) using PET and N-[11C]methylpiperidin-4-yl acetate. Donepezil 120-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 11171913-2 2001 Donepezil reduced k(3) values, an index of AChE activity, in the cerebral cortex by 39 +/- 5%. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 11328714-0 2001 QSAR for acetylcholinesterase inhibition and toxicity of two classes of phosphoramidothioates. phosphoramidothioates 72-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 11176277-1 2001 [11C]physostigmine, an acetylcholinesterase inhibitor, has been shown to be a promising positron emission tomography ligand to quantify the cerebral concentration of the enzyme in animals and humans in vivo. Carbon-11 1-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 11176277-1 2001 [11C]physostigmine, an acetylcholinesterase inhibitor, has been shown to be a promising positron emission tomography ligand to quantify the cerebral concentration of the enzyme in animals and humans in vivo. Physostigmine 5-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 11301094-1 2001 BACKGROUND: The hydrolysis enzymes of the acetylcholine, acetylcholinesterase, and butyrylcholinesterase are involved in non-cholinergic functions such as proliferation processes and cellular adhesion. Acetylcholine 42-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 11205075-3 2001 These clinical manifestations occur from liposoluble organophosphates or metabolites with long-lasting half time, causeing delayed inhibition of acetylcholinesterase and subsequent burn out of the neuromuscular junction from acetylcholine overstimulation. Organophosphates 53-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 11169626-1 2001 Acetylcholinesterase (AChE) can promote neurite outgrowth through a mechanism that is independent of its role in hydrolyzing the neurotransmitter acetylcholine. Acetylcholine 146-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 11169626-1 2001 Acetylcholinesterase (AChE) can promote neurite outgrowth through a mechanism that is independent of its role in hydrolyzing the neurotransmitter acetylcholine. Acetylcholine 146-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 11169626-5 2001 Furthermore, this adhesion is blocked by either an anti-AChE antibody or a highly specific AChE inhibitor (BW284c51), both of which have also been shown to block neurite outgrowth. Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide 107-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 11163034-0 2001 Novel test and its automation for the determination of erythrocyte acetylcholinesterase and its application to organophosphate exposure. Organophosphates 111-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 11163034-2 2001 METHODS: Acetylthiocholine, used as substrate, is hydrolysed by acetylcholinesterase to yield acetate and thiocholine. Acetylthiocholine 9-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 11163034-2 2001 METHODS: Acetylthiocholine, used as substrate, is hydrolysed by acetylcholinesterase to yield acetate and thiocholine. Acetates 94-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 11163034-2 2001 METHODS: Acetylthiocholine, used as substrate, is hydrolysed by acetylcholinesterase to yield acetate and thiocholine. Thiocholine 15-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 11163034-6 2001 Acetylcholinesterase values were in the range of 0-14 UgHb(-1) in cases of organophosphate poisoning, in contrast with normal controls, who had AChE values of 24.4--37.9 UgHb(-1). Organophosphates 75-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 11396871-1 2001 Galantamine, the most recently approved acetylcholinesterase inhibitor (AChEI) for use in the United States, has allosteric modulating activity at nicotinic receptors and inhibits acetylcholinesterase. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 11396871-1 2001 Galantamine, the most recently approved acetylcholinesterase inhibitor (AChEI) for use in the United States, has allosteric modulating activity at nicotinic receptors and inhibits acetylcholinesterase. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-200 11405996-1 2001 BACKGROUND: The main pharmacological approach for the treatment of Alzheimer"s disease (AD) has been based on the use of agents potentiating cholinergic transmission, particularly by inhibiting acetylcholinesterase (AChE), the enzyme that destroys acetylcholine after it has been secreted into the synaptic clefts. Acetylcholine 194-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 216-220 11405996-2 2001 Physostigmine is an AChE inhibitor originally extracted from calabar beans. Physostigmine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 11900310-4 2001 In the healthy brain, acetylcholinesterase (AChE) predominates (80%) and butyrylcholinesterase (BuChE) is considered to play a minor role in regulating brain ACh levels. Acetylcholine 44-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 11900310-9 2001 Experimental evidence from the use of agents with enhanced selectivity for BuChE (cymserine, MF-8622) and ChE inhibitors such as rivastigmine, which have a dual inhibitory action on both AChE and BuChE, indicate potential therapeutic benefits of inhibiting both AChE and BuChE in AD and related dementias. mf-8622 93-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 11900310-9 2001 Experimental evidence from the use of agents with enhanced selectivity for BuChE (cymserine, MF-8622) and ChE inhibitors such as rivastigmine, which have a dual inhibitory action on both AChE and BuChE, indicate potential therapeutic benefits of inhibiting both AChE and BuChE in AD and related dementias. Rivastigmine 129-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 11900310-9 2001 Experimental evidence from the use of agents with enhanced selectivity for BuChE (cymserine, MF-8622) and ChE inhibitors such as rivastigmine, which have a dual inhibitory action on both AChE and BuChE, indicate potential therapeutic benefits of inhibiting both AChE and BuChE in AD and related dementias. Rivastigmine 129-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 262-266 11853384-1 2001 In this study, acetylcholinesterase (AChE) and choline oxidase (ChO) were co-immobilized on poly(2-hydroxyethyl methacrylate) (pHEMA) membranes with the aim of using them in biosensor construction. Polyhydroxyethyl Methacrylate 92-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 11853384-1 2001 In this study, acetylcholinesterase (AChE) and choline oxidase (ChO) were co-immobilized on poly(2-hydroxyethyl methacrylate) (pHEMA) membranes with the aim of using them in biosensor construction. Polyhydroxyethyl Methacrylate 92-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 11341928-0 2001 Comparison of salt effects on the reactions of acetylcholinesterase with cationic and anionic inhibitors. Salts 14-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 11341928-1 2001 The influence of inorganic salts on the inhibition of acetylcholinesterase by charged organophosphorous inhibitors has been studied. inorganic salts 17-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 11341928-1 2001 The influence of inorganic salts on the inhibition of acetylcholinesterase by charged organophosphorous inhibitors has been studied. organophosphorous 86-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 11341928-2 2001 It has been shown that the salt effect on the reaction of acetylcholinesterase with anionic bis(p-nitrophenyl) phosphate is determined by the influence of added salts on the activity coefficient of the inhibitor. bis(4-nitrophenyl)phosphate 92-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 11341928-3 2001 In contrast to the salt effects on the reaction of acetylcholinesterase with cationic compounds, it does not include contribution from the enzyme charges. Salts 19-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 11141093-1 2001 In a search for less flexible analogues of caproctamine (1), a diamine diamide endowed with an interesting AChE affinity profile, we discovered compound 2, in which the terminal 2-methoxybenzyl groups of 1 have been incorporated into a tricyclic system. caproctamine 43-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 11801199-0 2001 Acetylcholinesterase assay for cerebrospinal fluid using bupivacaine to inhibit butyrylcholinesterase. Bupivacaine 57-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 11801199-8 2001 These equations allow us to calculate the acetylcholinesterase activity in solutions containing both cholinesterases utilizing the extinction differences measured spectrophotometrically in samples with and without bupivacaine. Bupivacaine 214-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 11801199-11 2001 CONCLUSIONS: The bupivacaine-inhibition test is a reliable method using spectrophotometrical techniques to measure acetylcholinesterase activity in cerebrospinal fluid. Bupivacaine 17-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 11893059-2 2001 The earliest known AChE inhibitors, namely, physostigmine and tacrine, performed poorly in clinical trials (e.g., poor oral activity, brain penetration, and hepatotoxic liability). Physostigmine 44-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 11893059-2 2001 The earliest known AChE inhibitors, namely, physostigmine and tacrine, performed poorly in clinical trials (e.g., poor oral activity, brain penetration, and hepatotoxic liability). Tacrine 62-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 11893059-4 2001 Donepezil hydrochloride inaugurates a new class of AChE inhibitors with longer and more selective action and with manageable adverse effects. donepezil hydrochloride inaugurates 0-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 11830754-3 2001 Donepezil is a piperidine-based, reversible acetylcholinesterase inhibitor, that is chemically unrelated to other cholinesterase inhibitors. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 11830754-3 2001 Donepezil is a piperidine-based, reversible acetylcholinesterase inhibitor, that is chemically unrelated to other cholinesterase inhibitors. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-64 11830754-3 2001 Donepezil is a piperidine-based, reversible acetylcholinesterase inhibitor, that is chemically unrelated to other cholinesterase inhibitors. piperidine 15-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 11830754-3 2001 Donepezil is a piperidine-based, reversible acetylcholinesterase inhibitor, that is chemically unrelated to other cholinesterase inhibitors. piperidine 15-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-64 11830754-5 2001 Donepezil is highly selective for acetylcholinesterase with a significantly lower affinity for butyrylcholinesterase, which is present predominantly in the periphery. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 11180275-0 2001 Pralidoxime and l-lactate effects in vitro on the inhibition of acetylcholinesterase by paraoxon: pralidoxime does not confer superior protection. pralidoxime 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 11180275-0 2001 Pralidoxime and l-lactate effects in vitro on the inhibition of acetylcholinesterase by paraoxon: pralidoxime does not confer superior protection. L-lactate 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 11180275-3 2001 Recent work has shown that under certain conditions l-lactate is also able to reduce in vitro the POX inhibition of butyrylcholine- and acetylcholineesterase (BChE and AChE). L-lactate 52-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-172 11180275-5 2001 Effects of PRX on the inhibition of AChE by POX were assessed in vitro in plasma of 12 (six male and six female) healthy human volunteers. Paraoxon 44-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 11180275-9 2001 In the micro- and millimolar ranges, PRX is able to protect in vitro AChE from inhibition by POX when added to human plasma prior to POX or when incubated with POX prior to addition to plasma. Paraoxon 93-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 11281253-1 2001 In vitro study for the determination of the toxicity of some pesticides (glyphospate and paraquat) and cadmium chloride (CdCl2) on the activities of serum acetylcholinesterase (AChE), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (AlP), and acid phosphatase (AcP) is described. Cadmium Chloride 121-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-175 11281253-8 2001 The effect of CdCl2 was pronounced with AChE, ALT, AlP, and AcP, and no effect on LDH and AST was found. Cadmium Chloride 14-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 11449566-3 2001 Herein, we correctly predict the orientation and conformation of the galanthamine molecule in the active site of AChE from Torpedo californica (TcAChE) using a combination of rigid docking and flexible geometry optimization with a molecular mechanics force field. Galantamine 69-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 11696925-8 2001 Equation (3) accurately predicted AChE inhibition by methamidophos, coumaphos and EPN, but not by acephate. methamidophos 53-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 11696925-8 2001 Equation (3) accurately predicted AChE inhibition by methamidophos, coumaphos and EPN, but not by acephate. Coumaphos 68-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 11101304-1 2000 The effect of heparin on the conformation and stability of triple-helical peptide models of the collagen tail of asymmetric acetylcholinesterase expands our understanding of heparin interactions with proteins and presents an opportunity for clarifying the nature of binding of ligands to collagen triple-helix domains. Heparin 14-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 11101304-1 2000 The effect of heparin on the conformation and stability of triple-helical peptide models of the collagen tail of asymmetric acetylcholinesterase expands our understanding of heparin interactions with proteins and presents an opportunity for clarifying the nature of binding of ligands to collagen triple-helix domains. Heparin 174-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 11101304-2 2000 Within the collagen tail of AChE, there are two consensus sequences for heparin binding of the form BBXB, surrounded by additional basic residues. Heparin 72-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 11101304-2 2000 Within the collagen tail of AChE, there are two consensus sequences for heparin binding of the form BBXB, surrounded by additional basic residues. bbxb 100-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 11328714-1 2001 Methamidophos (Met) is a weak inhibitor of housefly head AChE but at the same time it is highly toxic to the common housefly. methamidophos 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 11328714-1 2001 Methamidophos (Met) is a weak inhibitor of housefly head AChE but at the same time it is highly toxic to the common housefly. methamidophos 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 11328714-4 2001 Acephate (Ace), like Met, is a poor inhibitor of AChE in vitro and has a comparable to Met insect toxicity in vivo. acephate 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 11328714-10 2001 The mammalian toxicity of Ace analogs may be due to interaction with an "allosteric" reaction center in the AChE. acephate 26-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 11123973-0 2000 Inhibition of acetylcholinesterase by (1S,3S)-isomalathion proceeds with loss of thiomethyl: kinetic and mass spectral evidence for an unexpected primary leaving group. Caffeine 38-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 11123973-1 2000 Previous work demonstrated kinetically that inhibition of mammalian acetylcholinesterase (AChE) by (1S)-isomalathions may proceed by loss of thiomethyl instead of the expected diethyl thiosuccinate as the primary leaving group followed by one of four possible modes of rapid aging. (1s)-isomalathions 99-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 11123973-1 2000 Previous work demonstrated kinetically that inhibition of mammalian acetylcholinesterase (AChE) by (1S)-isomalathions may proceed by loss of thiomethyl instead of the expected diethyl thiosuccinate as the primary leaving group followed by one of four possible modes of rapid aging. (1s)-isomalathions 99-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 11123973-1 2000 Previous work demonstrated kinetically that inhibition of mammalian acetylcholinesterase (AChE) by (1S)-isomalathions may proceed by loss of thiomethyl instead of the expected diethyl thiosuccinate as the primary leaving group followed by one of four possible modes of rapid aging. thiomethyl 141-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 11123973-1 2000 Previous work demonstrated kinetically that inhibition of mammalian acetylcholinesterase (AChE) by (1S)-isomalathions may proceed by loss of thiomethyl instead of the expected diethyl thiosuccinate as the primary leaving group followed by one of four possible modes of rapid aging. thiomethyl 141-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 11123973-1 2000 Previous work demonstrated kinetically that inhibition of mammalian acetylcholinesterase (AChE) by (1S)-isomalathions may proceed by loss of thiomethyl instead of the expected diethyl thiosuccinate as the primary leaving group followed by one of four possible modes of rapid aging. diethyl thiosuccinate 176-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 11123973-1 2000 Previous work demonstrated kinetically that inhibition of mammalian acetylcholinesterase (AChE) by (1S)-isomalathions may proceed by loss of thiomethyl instead of the expected diethyl thiosuccinate as the primary leaving group followed by one of four possible modes of rapid aging. diethyl thiosuccinate 176-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 11123973-2 2000 This study sought to identify the adduct that renders AChE refractory toward reactivation after inhibition with the (1S, 3S)-stereoisomer. Caffeine 116-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 11123973-3 2000 Electric eel acetylcholinesterase (EEAChE) was inhibited with the four stereoisomers of isomalathion, and rate constants for spontaneous and oxime-mediated reactivation (k(3)) were measured. Oximes 141-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-33 11122998-1 2000 Acetylcholinesterase inhibitors (ChEIs) enhance neuronal transmission by increasing the availability of acetylcholine in muscarinic and nicotinic receptors. Acetylcholine 104-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 11154847-7 2000 Cell adhesion was affected by the BChE inhibitor, ethopropazine, and the AChE peripheral site inhibitor, BW284c51, but not by eserine which binds to the active site. Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide 105-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 11129708-14 2000 Propoxur inhibition of acetylcholinesterase (AChE) activity (the target site of organophosphates and carbamates) indicated that in 1998, frequencies of insensitive AChE-based resistance were 9% in Cx. Organophosphates 80-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 11129708-14 2000 Propoxur inhibition of acetylcholinesterase (AChE) activity (the target site of organophosphates and carbamates) indicated that in 1998, frequencies of insensitive AChE-based resistance were 9% in Cx. Organophosphates 80-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 11129708-14 2000 Propoxur inhibition of acetylcholinesterase (AChE) activity (the target site of organophosphates and carbamates) indicated that in 1998, frequencies of insensitive AChE-based resistance were 9% in Cx. Carbamates 101-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 11129708-14 2000 Propoxur inhibition of acetylcholinesterase (AChE) activity (the target site of organophosphates and carbamates) indicated that in 1998, frequencies of insensitive AChE-based resistance were 9% in Cx. Carbamates 101-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 11129708-17 2000 The AChE inhibition coefficient (ki) with propoxur was 1.86+/-0.24 x 10(5) M(-)1 min(-1) for Cx. Propoxur 42-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 11101357-0 2000 New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer"s disease. Tacrine 4-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 11101357-0 2000 New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer"s disease. huperzine A 12-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 11101357-0 2000 New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer"s disease. huprines 33-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 11101357-1 2000 Several new 12-amino-6,7,10,11-tetrahydro-7, 11-methanocycloocta[b]quinoline derivatives (tacrine-huperzine A hybrids, huprines) have been synthesized and tested as acetylcholinesterase (AChE) inhibitors. 12-amino-6,7,10,11-tetrahydro-7, 11-methanocycloocta[b]quinoline 12-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-185 11101357-1 2000 Several new 12-amino-6,7,10,11-tetrahydro-7, 11-methanocycloocta[b]quinoline derivatives (tacrine-huperzine A hybrids, huprines) have been synthesized and tested as acetylcholinesterase (AChE) inhibitors. 12-amino-6,7,10,11-tetrahydro-7, 11-methanocycloocta[b]quinoline 12-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 11101357-1 2000 Several new 12-amino-6,7,10,11-tetrahydro-7, 11-methanocycloocta[b]quinoline derivatives (tacrine-huperzine A hybrids, huprines) have been synthesized and tested as acetylcholinesterase (AChE) inhibitors. Tacrine 90-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-185 11101357-1 2000 Several new 12-amino-6,7,10,11-tetrahydro-7, 11-methanocycloocta[b]quinoline derivatives (tacrine-huperzine A hybrids, huprines) have been synthesized and tested as acetylcholinesterase (AChE) inhibitors. Tacrine 90-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 11078202-2 2000 (-)-DMHA inhibits AChE with a Ki value approaching that of (-)-huperzine A, whereas (+)-DMHA shows no AChE inhibitory activity. (-)-dmha 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 10954708-1 2000 In mammalian brain, acetylcholinesterase (AChE) exists mostly as a tetramer of 70-kDa catalytic subunits that are linked through disulfide bonds to a hydrophobic subunit P of approximately 20 kDa. Disulfides 129-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 10954708-1 2000 In mammalian brain, acetylcholinesterase (AChE) exists mostly as a tetramer of 70-kDa catalytic subunits that are linked through disulfide bonds to a hydrophobic subunit P of approximately 20 kDa. Disulfides 129-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 11053835-7 2000 The present findings are consistent with the notion that the main role of this network is the proper positioning of the Glu202 carboxylate relative to the catalytic triad, thus defining its functional role in the interaction of acetylcholinesterase with substrates and inhibitors. glu202 carboxylate 120-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 228-248 11129124-2 2000 Galantamine is a reversible, competitive, tertiary alkaloid AChE inhibitor. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 11129124-4 2000 In addition to inhibition of AChE galantamine interacts allosterically with nicotinic acetylcholine receptors to potentiate the action of agonists at these receptors. Galantamine 34-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 11031092-4 2000 In MG patients, the open-loop gains of OKN increased significantly after the intramuscular injection of an acetylcholinesterase inhibitor, neostigmine, while the closed-loop OKN gains were not significantly changed. Neostigmine 139-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 11200085-6 2000 GSH-enrichment protected AChE activity in fresh (0 day) and stored (42 and 84 days) RBCs from Fe/ASC oxidation by 10, 23 and 26%, respectively, compared with not-enriched controls. Glutathione 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 11193105-9 2000 Following the injection of BDA into PPT, labeled terminals within LM-Sg were rather more concentrated in the AChE-positive portion. biotinylated dextran amine 27-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 11109984-10 2000 Acetylcholinesterase staining in neurons and fibers showed a similar pattern of NADPH-d distribution in the oviduct. NADP 80-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 10994012-1 2000 Three patients with REM behavior disorder whose nocturnal symptoms were markedly improved by treatment with the acetylcholinesterase inhibitor donepezil are reported. Donepezil 143-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 11200333-2 2000 Verapamil shortened the decay of multiquantal currents, the effect being enhanced after acetylcholinesterase inhibition. Verapamil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 11200333-3 2000 In muscles with inhibited acetylcholinesterase, verapamil promoted the depression of successive end-late currents in rhythmic nerve stimulation. Verapamil 48-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 11281253-1 2001 In vitro study for the determination of the toxicity of some pesticides (glyphospate and paraquat) and cadmium chloride (CdCl2) on the activities of serum acetylcholinesterase (AChE), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (AlP), and acid phosphatase (AcP) is described. glyphospate 73-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-175 11281253-1 2001 In vitro study for the determination of the toxicity of some pesticides (glyphospate and paraquat) and cadmium chloride (CdCl2) on the activities of serum acetylcholinesterase (AChE), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (AlP), and acid phosphatase (AcP) is described. Paraquat 89-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-175 11281253-1 2001 In vitro study for the determination of the toxicity of some pesticides (glyphospate and paraquat) and cadmium chloride (CdCl2) on the activities of serum acetylcholinesterase (AChE), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (AlP), and acid phosphatase (AcP) is described. Paraquat 89-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-181 11281253-1 2001 In vitro study for the determination of the toxicity of some pesticides (glyphospate and paraquat) and cadmium chloride (CdCl2) on the activities of serum acetylcholinesterase (AChE), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (AlP), and acid phosphatase (AcP) is described. Cadmium Chloride 103-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-175 11281253-1 2001 In vitro study for the determination of the toxicity of some pesticides (glyphospate and paraquat) and cadmium chloride (CdCl2) on the activities of serum acetylcholinesterase (AChE), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (AlP), and acid phosphatase (AcP) is described. Cadmium Chloride 103-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-181 11186600-13 2000 A study of rivastigmine in patients with Alzheimer disease revealed that cerebrospinal fluid AChE inhibition correlated well with cognitive performance, whereas peripheral inhibition did not. Rivastigmine 11-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 10998265-1 2000 Acetylcholinesterase is the primary target of organophosphorous and carbamate insecticides. organophosphorous 46-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 10998265-1 2000 Acetylcholinesterase is the primary target of organophosphorous and carbamate insecticides. Carbamates 68-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 11078030-1 2000 Three new cholinesterase inhibitors, donepezil, rivastigmine, and galantamine, all inhibit the enzyme AChE. Donepezil 37-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 11078030-1 2000 Three new cholinesterase inhibitors, donepezil, rivastigmine, and galantamine, all inhibit the enzyme AChE. Rivastigmine 48-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 11078030-1 2000 Three new cholinesterase inhibitors, donepezil, rivastigmine, and galantamine, all inhibit the enzyme AChE. Galantamine 66-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 11256231-0 2000 Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Donepezil 39-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 11256231-1 2000 This study was designed to compare the in vitro inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) of donepezil and some other cholinesterase (ChE) inhibitors which have been developed for the treatment of Alzheimer"s disease. Donepezil 135-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 11256231-1 2000 This study was designed to compare the in vitro inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) of donepezil and some other cholinesterase (ChE) inhibitors which have been developed for the treatment of Alzheimer"s disease. Donepezil 135-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 11256231-3 2000 The maximum ChE inhibition by physostigmine developed within 30-60 min, while the inhibitory effect of rivastigmine on AChE and BuChE activities reached its peak after 48 and 6 h, respectively. Rivastigmine 103-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 11256231-4 2000 The order of inhibitory potency (IC50) towards AChE activity under optimal assay conditions for each ChE inhibitor was: physostigmine (0.67 nM) > rivastigmine (4.3 nM) > donepezil (6.7 nM) > TAK-147 (12 nM) > tacrine (77 nM) > ipidacrine (270 nM). Physostigmine 120-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 11256231-4 2000 The order of inhibitory potency (IC50) towards AChE activity under optimal assay conditions for each ChE inhibitor was: physostigmine (0.67 nM) > rivastigmine (4.3 nM) > donepezil (6.7 nM) > TAK-147 (12 nM) > tacrine (77 nM) > ipidacrine (270 nM). Rivastigmine 146-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 11256231-4 2000 The order of inhibitory potency (IC50) towards AChE activity under optimal assay conditions for each ChE inhibitor was: physostigmine (0.67 nM) > rivastigmine (4.3 nM) > donepezil (6.7 nM) > TAK-147 (12 nM) > tacrine (77 nM) > ipidacrine (270 nM). Donepezil 170-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 11256231-4 2000 The order of inhibitory potency (IC50) towards AChE activity under optimal assay conditions for each ChE inhibitor was: physostigmine (0.67 nM) > rivastigmine (4.3 nM) > donepezil (6.7 nM) > TAK-147 (12 nM) > tacrine (77 nM) > ipidacrine (270 nM). TAK 147 191-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 11256231-4 2000 The order of inhibitory potency (IC50) towards AChE activity under optimal assay conditions for each ChE inhibitor was: physostigmine (0.67 nM) > rivastigmine (4.3 nM) > donepezil (6.7 nM) > TAK-147 (12 nM) > tacrine (77 nM) > ipidacrine (270 nM). Tacrine 209-216 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 11256231-4 2000 The order of inhibitory potency (IC50) towards AChE activity under optimal assay conditions for each ChE inhibitor was: physostigmine (0.67 nM) > rivastigmine (4.3 nM) > donepezil (6.7 nM) > TAK-147 (12 nM) > tacrine (77 nM) > ipidacrine (270 nM). amiridine 227-237 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 11256231-5 2000 The benzylpiperidine derivatives donepezil and TAK-147 showed high selectivity for AChE over BuChE. 1-benzylpiperidine 4-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 11256231-5 2000 The benzylpiperidine derivatives donepezil and TAK-147 showed high selectivity for AChE over BuChE. Donepezil 33-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 11256231-5 2000 The benzylpiperidine derivatives donepezil and TAK-147 showed high selectivity for AChE over BuChE. TAK 147 47-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 10869820-0 2000 The promoter of human acetylcholinesterase is activated by a cyclic adenosine 3",5"-monophosphate-dependent pathway in cultured NG108-15 neuroblastoma cells. Cyclic AMP 61-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 10996660-5 2000 The available data indicate that experimental data for most organophosphates evaluated are limited; most organophosphates are equally potent RBC AChE inhibitors in different mammalian species; NOELs from repeated exposure studies of variable duration are usually equivalent; and, no particular grouping based on organophosphate structure is consistently more potent than another. Organophosphates 105-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 10984725-5 2000 All patients were prescribed the AChE inhibitor donepezil (5 mg per day). Donepezil 48-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 10926855-1 2000 The collagen-like tail of asymmetric acetylcholinesterase (AChE) contains two heparin-binding domains (HBDs) that interact with heparan sulphate proteoglycans, determining the anchoring of the enzyme at the basal lamina and its specific localization at the neuromuscular junction. Heparin 78-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 10926855-9 2000 Moreover, BBXB-containing peptides that are less stable are more effective in displacing AChE, suggesting that the interaction region needs a significant amount of structural flexibility to better accommodate the ligand. bbxb 10-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 10976649-0 2000 Limited donepezil inhibition of acetylcholinesterase measured with positron emission tomography in living Alzheimer cerebral cortex. Donepezil 8-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 10976649-1 2000 Based on surrogate assays of peripheral red blood cells, reports state that widely prescribed doses of donepezil hydrochloride provide nearly complete inhibition of cerebral cortical acetylcholinesterase activity in the treatment of Alzheimer"s disease (AD). Donepezil 103-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-203 10976649-3 2000 After physostigmine, acetylcholinesterase inhibition averaged 52% in normal cerebral cortex. Physostigmine 6-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 10971047-4 2000 The two most common approaches to correcting these cholinergic deficits are to increase the synaptic availability of acetylcholine (ACh) by inhibiting acetylcholinesterase (AChE), or to mimic the effects of ACh (nicotinic agonists) by acting directly on nicotinic receptors. Acetylcholine 117-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-171 10971047-4 2000 The two most common approaches to correcting these cholinergic deficits are to increase the synaptic availability of acetylcholine (ACh) by inhibiting acetylcholinesterase (AChE), or to mimic the effects of ACh (nicotinic agonists) by acting directly on nicotinic receptors. Acetylcholine 117-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-177 10971047-4 2000 The two most common approaches to correcting these cholinergic deficits are to increase the synaptic availability of acetylcholine (ACh) by inhibiting acetylcholinesterase (AChE), or to mimic the effects of ACh (nicotinic agonists) by acting directly on nicotinic receptors. Acetylcholine 132-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-171 10971047-4 2000 The two most common approaches to correcting these cholinergic deficits are to increase the synaptic availability of acetylcholine (ACh) by inhibiting acetylcholinesterase (AChE), or to mimic the effects of ACh (nicotinic agonists) by acting directly on nicotinic receptors. Acetylcholine 132-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-177 10971047-13 2000 As well as modulating nAChR, galantamine inhib- its AChE. Galantamine 29-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 10971047-15 2000 However, galantamine maintains patients" level of cognitive and daily function for at least 1 year, which has not been reported for other AChE inhibitors. Galantamine 9-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 10971048-1 2000 Galantamine, a novel treatment for Alzheimer"s disease (AD), has a dual mechanism of action, combining allosteric modulation of nicotinic acetylcholine receptors with reversible, competitive inhibition of acetylcholinesterase. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 205-225 10971049-5 2000 Galantamine is a new treatment for AD that combines modulation of nicotinic receptors with inhibition of acetylcholinesterase. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 11204553-0 2000 Rates of spontaneous reactivation and aging of acetylcholinesterase in human erythrocytes after inhibition by organophosphorus pesticides. organophosphorus 110-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 11204553-6 2000 In contrast a substantial proportion of the erythrocyte acetylcholinesterase is found unaged and therefore sensitive to reactivation by oximes. Oximes 136-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 11204553-8 2000 These data also confirm that the plasma enzyme is a more sensitive than erythrocyte acetylcholinesterase as an indicator of OP exposure and thus the potential value of ex vivo oxime reactivation of erythrocyte acetylcholinesterase in a blood sample to indicate subclinical OP exposure may be limited. Oximes 176-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-230 10874131-0 2000 Kinetics of human acetylcholinesterase inhibition by the novel experimental Alzheimer therapeutic agent, tolserine. tolserine 105-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 10924143-5 2000 The density distribution showed that AChE is not transferred to the liposomes but is located on small (about 50 nm) light (10-20 wt % sucrose) or large (about 200 nm) heavy shed vesicles (more than 30 wt % sucrose). Sucrose 134-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 10924143-5 2000 The density distribution showed that AChE is not transferred to the liposomes but is located on small (about 50 nm) light (10-20 wt % sucrose) or large (about 200 nm) heavy shed vesicles (more than 30 wt % sucrose). Sucrose 206-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 10939570-1 2000 We measured brain acetylcholinesterase activity in 30 patients with Alzheimer"s disease (AD) and 14 age-matched controls by positron emission tomography (PET) and using a carbon 11-labeled acetylcholine analogue. Carbon-11 171-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 10869474-2 2000 Inhibition of acetylcholinesterase (AChE) by OPs leads to a decrease in acetylcholine (ACh) breakdown that results in overstimulation of muscarinic cholinergic receptors (mChR). OPS 45-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 10869474-2 2000 Inhibition of acetylcholinesterase (AChE) by OPs leads to a decrease in acetylcholine (ACh) breakdown that results in overstimulation of muscarinic cholinergic receptors (mChR). OPS 45-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 10869474-2 2000 Inhibition of acetylcholinesterase (AChE) by OPs leads to a decrease in acetylcholine (ACh) breakdown that results in overstimulation of muscarinic cholinergic receptors (mChR). Acetylcholine 14-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 10869474-2 2000 Inhibition of acetylcholinesterase (AChE) by OPs leads to a decrease in acetylcholine (ACh) breakdown that results in overstimulation of muscarinic cholinergic receptors (mChR). Acetylcholine 36-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 11034785-1 2000 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) from vertebrates, other than their predominant acylcholine hydrolase (esterase) activity, display a genuine aryl acylamidase activity (AAA) capable of hydrolyzing the synthetic substrate o-nitroacetanilide to o-nitroaniline. 2-nitroacetanilide 248-266 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 11034785-1 2000 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) from vertebrates, other than their predominant acylcholine hydrolase (esterase) activity, display a genuine aryl acylamidase activity (AAA) capable of hydrolyzing the synthetic substrate o-nitroacetanilide to o-nitroaniline. 2-nitroacetanilide 248-266 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 11034785-1 2000 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) from vertebrates, other than their predominant acylcholine hydrolase (esterase) activity, display a genuine aryl acylamidase activity (AAA) capable of hydrolyzing the synthetic substrate o-nitroacetanilide to o-nitroaniline. 2-nitroaniline 270-284 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 11034785-1 2000 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) from vertebrates, other than their predominant acylcholine hydrolase (esterase) activity, display a genuine aryl acylamidase activity (AAA) capable of hydrolyzing the synthetic substrate o-nitroacetanilide to o-nitroaniline. 2-nitroaniline 270-284 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 10899554-0 2000 Acetylcholine biosensor involving entrapment of acetylcholinesterase and poly(ethylene glycol)-modified choline oxidase in a poly(vinyl alcohol) cryogel membrane. Acetylcholine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 10899554-1 2000 A bienzymatic sensor for the determination of acetylcholine was prepared by physical coimmobilization of acetylcholinesterase and poly(ethylene glycol)-modified choline oxidase in a poly(vinyl alcohol) cryogel membrane obtained by a cyclic freezing-thawing process. Acetylcholine 46-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 10899554-1 2000 A bienzymatic sensor for the determination of acetylcholine was prepared by physical coimmobilization of acetylcholinesterase and poly(ethylene glycol)-modified choline oxidase in a poly(vinyl alcohol) cryogel membrane obtained by a cyclic freezing-thawing process. Polyvinyl Alcohol 182-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 11275256-1 2000 We have previously described a catalytic monoclonal antibody, raised against acetylcholinesterase (AChE) and capable of hydrolysing acetylthiocholine. Acetylthiocholine 132-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 11275256-1 2000 We have previously described a catalytic monoclonal antibody, raised against acetylcholinesterase (AChE) and capable of hydrolysing acetylthiocholine. Acetylthiocholine 132-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 11275256-5 2000 The antibodies recognised AchE and were capable of hydrolysing acetylthiocholine and the larger butyrylthiocholine substrate, and were inactivated by phenylmethylsulphonyl fluoride (PMSF), indicating a serine residue in the active site. Butyrylthiocholine 96-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 11275256-5 2000 The antibodies recognised AchE and were capable of hydrolysing acetylthiocholine and the larger butyrylthiocholine substrate, and were inactivated by phenylmethylsulphonyl fluoride (PMSF), indicating a serine residue in the active site. Phenylmethylsulfonyl Fluoride 150-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 11275256-5 2000 The antibodies recognised AchE and were capable of hydrolysing acetylthiocholine and the larger butyrylthiocholine substrate, and were inactivated by phenylmethylsulphonyl fluoride (PMSF), indicating a serine residue in the active site. Phenylmethylsulfonyl Fluoride 182-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 11275256-5 2000 The antibodies recognised AchE and were capable of hydrolysing acetylthiocholine and the larger butyrylthiocholine substrate, and were inactivated by phenylmethylsulphonyl fluoride (PMSF), indicating a serine residue in the active site. Serine 202-208 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 11275256-9 2000 They were also partially inhibited by the AChE-specific inhibitors, BW284c51 and propidium. Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide 68-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 11275256-9 2000 They were also partially inhibited by the AChE-specific inhibitors, BW284c51 and propidium. Propidium 81-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 11003259-0 2000 Effect of combined treatment with perindoprilat and low-power red light laser irradiation on human erythrocyte membrane fluidity, membrane potential and acetylcholinesterase activity. perindoprilat 34-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-173 11003259-5 2000 Perindoprilat has an additional inhibitory effect on the activity of acetylcholinesterase, whereas laser irradiation causes an increase in the activity of the enzyme. perindoprilat 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 10779503-0 2000 Probing the active center gorge of acetylcholinesterase by fluorophores linked to substituted cysteines. Cysteine 94-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 10869180-0 2000 Acetylthiocholine binds to asp74 at the peripheral site of human acetylcholinesterase as the first step in the catalytic pathway. Acetylthiocholine 0-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 10869180-6 2000 In this report, we demonstrate that a key residue in the human AChE peripheral site with which the substrate acetylthiocholine interacts is D74. Acetylthiocholine 109-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 10869180-8 2000 For human AChE, a K(S) of 1.9+/-0.7 mM obtained by fitting this substrate inhibition curve agreed with a K(S) of 1.3+/-1.0 mM measured directly from acetylthiocholine inhibition of the binding of the neurotoxin fasciculin to the peripheral site. Acetylthiocholine 149-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-14 10869180-13 2000 This inhibitory effect, measured by the relative decrease in the first-order phosphorylation rate constant k(OP) for the neutral organophosphate 7-[(methylethoxyphosphonyl)oxy]-4-methylcoumarin (EMPC) that resulted from fasciculin binding, decreased from 0.002 in wild-type human AChE to 0.24 in the D74G mutant. Organophosphates 129-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 280-284 10869180-13 2000 This inhibitory effect, measured by the relative decrease in the first-order phosphorylation rate constant k(OP) for the neutral organophosphate 7-[(methylethoxyphosphonyl)oxy]-4-methylcoumarin (EMPC) that resulted from fasciculin binding, decreased from 0.002 in wild-type human AChE to 0.24 in the D74G mutant. 7-[(methylethoxyphosphonyl)oxy]-4-methylcoumarin 145-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 280-284 10869820-1 2000 Different transcription elements have been proposed to play a role in the regulation of acetylcholinesterase (AChE) in muscle and neuron, and cyclic adenosine 3",5"-monophosphate (cAMP)-dependent pathway is one of them. Cyclic AMP 142-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 10869820-1 2000 Different transcription elements have been proposed to play a role in the regulation of acetylcholinesterase (AChE) in muscle and neuron, and cyclic adenosine 3",5"-monophosphate (cAMP)-dependent pathway is one of them. Cyclic AMP 142-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 11343620-4 2000 Donepezil is a second-generation, piperidine-class, selective and reversible acetylcholinesterase inhibitor. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 11343620-4 2000 Donepezil is a second-generation, piperidine-class, selective and reversible acetylcholinesterase inhibitor. piperidine 34-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 10909423-1 2000 The acetylcholine-hydrolyzing enzyme, acetylcholinesterase, is the molecular target of approved drugs for Alzheimer"s disease and myasthenia gravis. Acetylcholine 4-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 10942900-0 2000 L-lactate protects in vitro acetylcholinesterase (AChE) from inhibition by paraoxon (E 600). L-lactate 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 10942900-0 2000 L-lactate protects in vitro acetylcholinesterase (AChE) from inhibition by paraoxon (E 600). L-lactate 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 10910502-3 2000 Cholinesterases such as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) hydrolyze and inactivate several anesthetic drugs, including cocaine, heroin, esmolol, local ester anesthetics, and neuromuscular blocking drugs. Cocaine 147-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 10942900-0 2000 L-lactate protects in vitro acetylcholinesterase (AChE) from inhibition by paraoxon (E 600). Paraoxon 75-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 10910502-3 2000 Cholinesterases such as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) hydrolyze and inactivate several anesthetic drugs, including cocaine, heroin, esmolol, local ester anesthetics, and neuromuscular blocking drugs. esmolol 164-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 10942900-0 2000 L-lactate protects in vitro acetylcholinesterase (AChE) from inhibition by paraoxon (E 600). Paraoxon 75-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 10910502-3 2000 Cholinesterases such as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) hydrolyze and inactivate several anesthetic drugs, including cocaine, heroin, esmolol, local ester anesthetics, and neuromuscular blocking drugs. Esters 6-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 10942900-5 2000 Effects of lactate on the inhibition of AChE by POX were assessed in vitro in plasma of 12 (six male, six female) healthy human volunteers. Lactic Acid 11-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 10942900-5 2000 Effects of lactate on the inhibition of AChE by POX were assessed in vitro in plasma of 12 (six male, six female) healthy human volunteers. Paraoxon 48-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 10942900-8 2000 In the micro- and millimolar ranges, lactate is able to protect in vitro AChE from inhibition by POX when added to human plasma prior to POX or when incubated with POX prior to addition to plasma. Lactic Acid 37-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 10942900-8 2000 In the micro- and millimolar ranges, lactate is able to protect in vitro AChE from inhibition by POX when added to human plasma prior to POX or when incubated with POX prior to addition to plasma. Paraoxon 97-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 10942900-10 2000 In a second set of experiments, the effect of lactate on AChE activity was determined. Lactic Acid 46-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 10942900-11 2000 At high millimolar concentrations, lactate itself inhibits AChE non-competitively (mixed inhibition) to an extent comparable to POX (inhibition constant K(I) = 254 mM). Lactic Acid 35-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 10890154-1 2000 Natural product acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor pyripyropene A was synthetically converted to acetylcholinesterase (AChE) inhibitor via heterolitic cleavage of the 2-pyrone ring, followed by gamma-acylation/cyclization with several aroyl chlorides. pyripyropene A 70-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 10943943-3 2000 Tacrine significantly increased the value of deltaG, deltaH, deltaH*, Q10, Ea and PZ factor, and decreased the value of deltaS for AChE. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 10943943-4 2000 Since there is no known report on the inhibition of human retinal AChE by tacrine, these results were compared with the reported values for the energy parameters of camel retinal and chicken brain AChE inhibition by an anti-cancer drug, cyclophosphamide. Tacrine 74-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 10890154-1 2000 Natural product acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor pyripyropene A was synthetically converted to acetylcholinesterase (AChE) inhibitor via heterolitic cleavage of the 2-pyrone ring, followed by gamma-acylation/cyclization with several aroyl chlorides. pyripyropene A 70-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 10890154-1 2000 Natural product acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor pyripyropene A was synthetically converted to acetylcholinesterase (AChE) inhibitor via heterolitic cleavage of the 2-pyrone ring, followed by gamma-acylation/cyclization with several aroyl chlorides. 2-pyrone 186-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 10890154-1 2000 Natural product acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor pyripyropene A was synthetically converted to acetylcholinesterase (AChE) inhibitor via heterolitic cleavage of the 2-pyrone ring, followed by gamma-acylation/cyclization with several aroyl chlorides. 2-pyrone 186-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 10890154-1 2000 Natural product acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor pyripyropene A was synthetically converted to acetylcholinesterase (AChE) inhibitor via heterolitic cleavage of the 2-pyrone ring, followed by gamma-acylation/cyclization with several aroyl chlorides. aroyl chlorides 254-269 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 10890154-1 2000 Natural product acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor pyripyropene A was synthetically converted to acetylcholinesterase (AChE) inhibitor via heterolitic cleavage of the 2-pyrone ring, followed by gamma-acylation/cyclization with several aroyl chlorides. aroyl chlorides 254-269 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 10801325-0 2000 Mechanism of oxime reactivation of acetylcholinesterase analyzed by chirality and mutagenesis. Oximes 13-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 22033801-3 2000 Five such agents are reviewed: tacrine and donepezil, which act at the ionic subsite of acetylcholinesterase (AChE), and rivastigmine, galantamine, and metrifonate, which act at its catalytic esteratic subsite. Tacrine 31-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 22033801-3 2000 Five such agents are reviewed: tacrine and donepezil, which act at the ionic subsite of acetylcholinesterase (AChE), and rivastigmine, galantamine, and metrifonate, which act at its catalytic esteratic subsite. Tacrine 31-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 22033801-3 2000 Five such agents are reviewed: tacrine and donepezil, which act at the ionic subsite of acetylcholinesterase (AChE), and rivastigmine, galantamine, and metrifonate, which act at its catalytic esteratic subsite. Donepezil 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 22033801-3 2000 Five such agents are reviewed: tacrine and donepezil, which act at the ionic subsite of acetylcholinesterase (AChE), and rivastigmine, galantamine, and metrifonate, which act at its catalytic esteratic subsite. Donepezil 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 10801325-1 2000 Organophosphates inactivate acetylcholinesterase by reacting covalently with the active center serine. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 10801325-1 2000 Organophosphates inactivate acetylcholinesterase by reacting covalently with the active center serine. Serine 95-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 10801325-2 2000 We have examined the reactivation of a series of resolved enantiomeric methylphosphonate conjugates of acetylcholinesterase by two oximes, 2-pralidoxime (2-PAM) and 1-(2"-hydroxyiminomethyl-1"-pyridinium)-3-(4"-carbamoyl-1-pyridinium) (HI-6). methylphosphonic acid 71-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 10801325-2 2000 We have examined the reactivation of a series of resolved enantiomeric methylphosphonate conjugates of acetylcholinesterase by two oximes, 2-pralidoxime (2-PAM) and 1-(2"-hydroxyiminomethyl-1"-pyridinium)-3-(4"-carbamoyl-1-pyridinium) (HI-6). Oximes 131-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 10801325-2 2000 We have examined the reactivation of a series of resolved enantiomeric methylphosphonate conjugates of acetylcholinesterase by two oximes, 2-pralidoxime (2-PAM) and 1-(2"-hydroxyiminomethyl-1"-pyridinium)-3-(4"-carbamoyl-1-pyridinium) (HI-6). 2-pralidoxime 139-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 10801325-2 2000 We have examined the reactivation of a series of resolved enantiomeric methylphosphonate conjugates of acetylcholinesterase by two oximes, 2-pralidoxime (2-PAM) and 1-(2"-hydroxyiminomethyl-1"-pyridinium)-3-(4"-carbamoyl-1-pyridinium) (HI-6). 1-(2"-hydroxyiminomethyl-1"-pyridinium)-3-(4"-carbamoyl-1-pyridinium 165-233 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 10801325-2 2000 We have examined the reactivation of a series of resolved enantiomeric methylphosphonate conjugates of acetylcholinesterase by two oximes, 2-pralidoxime (2-PAM) and 1-(2"-hydroxyiminomethyl-1"-pyridinium)-3-(4"-carbamoyl-1-pyridinium) (HI-6). asoxime chloride 236-240 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 10821713-0 2000 SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylcholinesterase inhibitors: synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues. Tacrine 7-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 10826417-3 2000 Neostigmine enhances excitatory parasympathetic activity by competing with acetylcholine for attachment to acetylcholinesterase at sites of cholinergic transmission and enhancing cholinergic action. Neostigmine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 10821713-0 2000 SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylcholinesterase inhibitors: synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues. Tacrine 155-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 10821713-1 2000 In this study, we attempted to derive a comprehensive SAR picture for the class of acetylcholinesterase (AChE) inhibitors related to tacrine, a drug currently in use for the treatment of the Alzheimer"s disease. Tacrine 133-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 10821713-1 2000 In this study, we attempted to derive a comprehensive SAR picture for the class of acetylcholinesterase (AChE) inhibitors related to tacrine, a drug currently in use for the treatment of the Alzheimer"s disease. Tacrine 133-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 10821713-4 2000 The three-dimensional (3D) properties of the inhibitors were taken into consideration by performing a CoMFA analysis on the series of AChE inhibitors made by 12 9-amino-1,2,3, 4-tetrahydroacridines and 13 11H-indeno[1,2-b]quinolin-10-ylamines previously developed in our laboratory. Tacrine 161-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 10821713-4 2000 The three-dimensional (3D) properties of the inhibitors were taken into consideration by performing a CoMFA analysis on the series of AChE inhibitors made by 12 9-amino-1,2,3, 4-tetrahydroacridines and 13 11H-indeno[1,2-b]quinolin-10-ylamines previously developed in our laboratory. 11h-indeno[1,2-b]quinolin-10-ylamines 205-242 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 10821713-9 2000 The 6-bromo-9-amino-1,2,3,4-tetrahydroacridine was predicted to have a pIC(50) value of 7.31 by the classical QSAR model and 7.40 by the CoMFA model, while its experimental IC(50) value was equal to 0.066 (+/-0.009) microM, corresponding to a pIC(50) of 7.18, showing a reasonable agreement between predicted and observed AChE inhibition data. 6-bromo-9-amino-1,2,3,4-tetrahydroacridine 4-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 322-326 10821713-9 2000 The 6-bromo-9-amino-1,2,3,4-tetrahydroacridine was predicted to have a pIC(50) value of 7.31 by the classical QSAR model and 7.40 by the CoMFA model, while its experimental IC(50) value was equal to 0.066 (+/-0.009) microM, corresponding to a pIC(50) of 7.18, showing a reasonable agreement between predicted and observed AChE inhibition data. pic 71-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 322-326 10862247-7 2000 The possible causes include interactions between acetylcholinesterase inhibitors, neuroleptics and serotonine reuptake inhibitors and Lewy body dementia. Serotonin 99-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 10826417-3 2000 Neostigmine enhances excitatory parasympathetic activity by competing with acetylcholine for attachment to acetylcholinesterase at sites of cholinergic transmission and enhancing cholinergic action. Acetylcholine 75-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 10798623-11 2000 In the group exposed to mercury vapours, a significant decrease was found in G-6PD activity (23.9%, P<0.001), GR (18.8%, P<0.001), and SOD (5%, P<0.001) with a concomitant increase in AChE activity (35.9%, P<0.001) was found. Mercury 24-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-197 10773217-3 2000 We now report that an irreversible AChE inhibitor (metrifonate) increase the cell-associated APP level in a basal forebrain neuronal culture and also elevate the amount of APP secreted into the medium. Trichlorfon 51-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 10762042-2 2000 Compounds 6b-c were found to be more potent than galanthamine and tacrine in inhibiting AChE. Galantamine 49-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 10762042-2 2000 Compounds 6b-c were found to be more potent than galanthamine and tacrine in inhibiting AChE. Tacrine 66-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 10749487-4 2000 The detection limit of galanthamine, an AChE inhibitor, in the HPLC-biochemical detection is 0.3 nmol. Galantamine 23-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 10637365-3 2000 These data are summarised from nearly all therapeutically important chemical classes of reversible AChE inhibitors, e.g., derivatives of physostigmine, tacrine, donepezil and huperzine A. Interactions observed from X-ray crystallography between these inhibitors and AChE have also been incorporated and compared with modelling and QSAR results. Physostigmine 137-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 10637365-3 2000 These data are summarised from nearly all therapeutically important chemical classes of reversible AChE inhibitors, e.g., derivatives of physostigmine, tacrine, donepezil and huperzine A. Interactions observed from X-ray crystallography between these inhibitors and AChE have also been incorporated and compared with modelling and QSAR results. Tacrine 152-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 10637365-3 2000 These data are summarised from nearly all therapeutically important chemical classes of reversible AChE inhibitors, e.g., derivatives of physostigmine, tacrine, donepezil and huperzine A. Interactions observed from X-ray crystallography between these inhibitors and AChE have also been incorporated and compared with modelling and QSAR results. Donepezil 161-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 10637365-3 2000 These data are summarised from nearly all therapeutically important chemical classes of reversible AChE inhibitors, e.g., derivatives of physostigmine, tacrine, donepezil and huperzine A. Interactions observed from X-ray crystallography between these inhibitors and AChE have also been incorporated and compared with modelling and QSAR results. huperzine A 175-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 10637365-4 2000 It is concluded that hydrophobicity and the presence of an ionizable nitrogen are the pre-requisites for the inhibitors to interact with AChE. Nitrogen 69-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 10637367-3 2000 The earliest known AChE inhibitors, namely, physostigmine and tacrine, showed modest improvement in the cognitive function of Alzheimer"s patients. Physostigmine 44-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 10637367-3 2000 The earliest known AChE inhibitors, namely, physostigmine and tacrine, showed modest improvement in the cognitive function of Alzheimer"s patients. Tacrine 62-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 10637367-6 2000 Donepezil hydrochloride inaugurates a new class of AChE inhibitors with longer and more selective action with manageable adverse effects. donepezil hydrochloride inaugurates 0-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 10637368-0 2000 Central selective acetylcholinesterase inhibitor with neurotrophic activity: structure-activity relationships of TAK-147 and related compounds. TAK 147 113-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 10637368-7 2000 Furthermore, TAK-147 was revealed to have NGF-like neurotrophic activity on central cholinergic neurons at concentrations where it inhibits AChE activity. TAK 147 13-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 10637368-8 2000 Therefore, TAK-147 is expected not only to ameliorate the clinical symptoms in Alzheimer s disease via AChE inhibition but to prevent or slow the progression of the disease via its neurotrophic action. TAK 147 11-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 10889515-2 2000 Studies were carried out on rural workers in Brazil to determine the decrease in the activity of plasma butyrylcholinesterase (BChE), erythrocyte cholinesterase (AChE) associated with exposure to organophosphorus pesticides (OP). organophosphorus 196-212 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-166 10713582-3 2000 Rivastigmine is an AChE inhibitor that is enzymatically cleaved by AChE, minimally metabolized by cytochrome P450 enzymes, has low protein binding, has a short plasma half-life, and a relatively short duration of action. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 10713582-3 2000 Rivastigmine is an AChE inhibitor that is enzymatically cleaved by AChE, minimally metabolized by cytochrome P450 enzymes, has low protein binding, has a short plasma half-life, and a relatively short duration of action. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 10736973-5 2000 METHODS: We used the antidopaminergic agent metoclopramide (MCP) and the acetylcholinesterase inhibitor pyridostigmine, which enhances acetylcholine and thus inhibits hypothalamic somatostatin release. Pyridostigmine Bromide 104-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 10737358-5 2000 The current study investigated whether memantine would attenuate the inhibition of AChE produced by these three drugs. Memantine 39-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 10737358-7 2000 Our in vitro data suggest that the clinical combination of memantine with a reversible AChE inhibitor should be a valuable pharmacotherapeutic approach to dementia. Memantine 59-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 10653663-0 2000 Evidence for P-N bond scission in phosphoroamidate nerve agent adducts of human acetylcholinesterase. phosphoroamidate 34-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 10653663-3 2000 While AChE adducts with phosphonates and phosphates are known to age through scission of the alkoxy C-O bond, the aging path for adducts with phosphoroamidates (P-N agents) like the nerve agent N,N-dimethylphosphonocyanoamidate (tabun) is not clear. Organophosphonates 24-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 10653663-3 2000 While AChE adducts with phosphonates and phosphates are known to age through scission of the alkoxy C-O bond, the aging path for adducts with phosphoroamidates (P-N agents) like the nerve agent N,N-dimethylphosphonocyanoamidate (tabun) is not clear. n,n-dimethylphosphonocyanoamidate 194-227 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 10665486-1 2000 The end-plate species of acetylcholinesterase (AChE) is an asymmetric enzyme consisting of a collagenic tail subunit composed of three collagenic strands (ColQ), each attached to a tetramer of the T isoform of the catalytic subunit (AChE(T)) via a proline-rich attachment domain. Proline 248-255 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 10665486-1 2000 The end-plate species of acetylcholinesterase (AChE) is an asymmetric enzyme consisting of a collagenic tail subunit composed of three collagenic strands (ColQ), each attached to a tetramer of the T isoform of the catalytic subunit (AChE(T)) via a proline-rich attachment domain. Proline 248-255 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 10718513-1 2000 Previously, we have shown that physostigmine, an acetylcholinesterase inhibitor, improved performance on a working memory for faces task, as reflected by reduced reaction time (RT), and reduced task-specific regional cerebral blood flow (rCBF) in right prefrontal cortex and, further, that these reductions in RT and right frontal rCBF were significantly correlated. Physostigmine 31-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 10648696-4 2000 First, we show that tetrodotoxin (TTX) reversibly suppresses accumulation of cell surface AChE clusters, whereas veratridine or scorpion venom (ScVn) increase them. Tetrodotoxin 20-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 10648696-4 2000 First, we show that tetrodotoxin (TTX) reversibly suppresses accumulation of cell surface AChE clusters, whereas veratridine or scorpion venom (ScVn) increase them. Tetrodotoxin 34-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 10648696-7 2000 When a segment of myotube is exposed to TTX, AChE cluster formation is suppressed only on that region. Tetrodotoxin 40-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 10648652-0 2000 Huprine X is a novel high-affinity inhibitor of acetylcholinesterase that is of interest for treatment of Alzheimer"s disease. huprine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 10648652-2 2000 Huperzine A, a natural product used in traditional Chinese herbal medicine, and tacrine (Cognex) are among the potent AChE inhibitors used in this treatment, but the search for more selective inhibitors continues. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 10648652-2 2000 Huperzine A, a natural product used in traditional Chinese herbal medicine, and tacrine (Cognex) are among the potent AChE inhibitors used in this treatment, but the search for more selective inhibitors continues. Tacrine 80-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 10648652-2 2000 Huperzine A, a natural product used in traditional Chinese herbal medicine, and tacrine (Cognex) are among the potent AChE inhibitors used in this treatment, but the search for more selective inhibitors continues. Tacrine 89-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 10648652-4 2000 Huprine X inhibited human AChE with an inhibition constant K(I) of 26 pM, indicating that it binds to this enzyme with one of the highest affinities yet reported. huprine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 10648652-5 2000 Under equivalent assay conditions, this affinity was 180 times that of huperzine A, 1200 times that of tacrine, and 40 times that of E2020 (donepezil, Aricept), the most selective AChE inhibitor currently approved for therapeutic use. Donepezil 140-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 10648652-5 2000 Under equivalent assay conditions, this affinity was 180 times that of huperzine A, 1200 times that of tacrine, and 40 times that of E2020 (donepezil, Aricept), the most selective AChE inhibitor currently approved for therapeutic use. Donepezil 151-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 10648652-6 2000 The association and dissociation rate constants for huprine X with AChE were determined, and the location of its binding site on the enzyme was probed in competition studies with the peripheral site inhibitor propidium and the acylation site inhibitor edrophonium. huprine 52-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 10648652-8 2000 In contrast, huprine X did form a ternary complex with propidium and AChE, although its affinity for the free enzyme was found to be 17 times its affinity for the propidium-AChE complex. huprine 13-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 10648652-8 2000 In contrast, huprine X did form a ternary complex with propidium and AChE, although its affinity for the free enzyme was found to be 17 times its affinity for the propidium-AChE complex. huprine 13-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-177 10648652-8 2000 In contrast, huprine X did form a ternary complex with propidium and AChE, although its affinity for the free enzyme was found to be 17 times its affinity for the propidium-AChE complex. Propidium 163-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-177 10771016-5 2000 In human temporal cortex loss of acetylcholinesterase catalytic activity is positively correlated with decreased epibatidine binding and in a transgenic mouse model over expressing acetylcholinesterase, epibatidine binding is elevated. epibatidine 113-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 10771016-5 2000 In human temporal cortex loss of acetylcholinesterase catalytic activity is positively correlated with decreased epibatidine binding and in a transgenic mouse model over expressing acetylcholinesterase, epibatidine binding is elevated. epibatidine 203-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 10817663-1 2000 The reactivation of organophosphate-inhibited acetylcholinesterase (AChE) by oximes inevitably results in the formation of highly reactive phosphoryloximes (POX), which are able to re-inhibit the enzyme. Organophosphates 20-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 10817663-1 2000 The reactivation of organophosphate-inhibited acetylcholinesterase (AChE) by oximes inevitably results in the formation of highly reactive phosphoryloximes (POX), which are able to re-inhibit the enzyme. Oximes 77-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 10817663-2 2000 In this study, the dependence of POX formation on AChE concentration was investigated with sarin-inhibited human erythrocyte AChE (EryAChE). CHEMBL255237 33-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 10817663-2 2000 In this study, the dependence of POX formation on AChE concentration was investigated with sarin-inhibited human erythrocyte AChE (EryAChE). CHEMBL255237 33-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 10817663-9 2000 The results indicate that obidoxime and 2-PAM may reactivate sarin-inhibited AChE insufficiently due to re-inhibition by the POX formed. Obidoxime Chloride 26-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 10817664-3 2000 Human plasma with the butyrylcholinesterase irreversibly blocked by soman was able to stimulate obidoxime-induced reactivation of concentrated erythrocyte acetylcholinesterase (Ery-AChE) to the same extent as was observed with a dilute preparation, suggesting phosphoryl oxime-destroying capacity. Obidoxime Chloride 96-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 10817664-3 2000 Human plasma with the butyrylcholinesterase irreversibly blocked by soman was able to stimulate obidoxime-induced reactivation of concentrated erythrocyte acetylcholinesterase (Ery-AChE) to the same extent as was observed with a dilute preparation, suggesting phosphoryl oxime-destroying capacity. Oximes 100-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 10798623-13 2000 Our results indicate that long-term exposure to mercury vapours induces changes in the activity of red cell enzymes--G-6PD, AChE, GR and SOD--and may also influence other important hematological parameters of the peripheral blood. Mercury 48-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 14564607-1 2000 PURPOSE: The kinetics of the inhibition of human plasma cholinesterase (ChE) and erythrocyte acetylcholinesterase (AChE) by alcuronium, atracurium, d-tubocurarine, pancuronium, pipecuronium, and vecuronium were studied in blood drawn from 35 surgical patients. Alcuronium 124-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 14564607-1 2000 PURPOSE: The kinetics of the inhibition of human plasma cholinesterase (ChE) and erythrocyte acetylcholinesterase (AChE) by alcuronium, atracurium, d-tubocurarine, pancuronium, pipecuronium, and vecuronium were studied in blood drawn from 35 surgical patients. Alcuronium 124-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 14564607-1 2000 PURPOSE: The kinetics of the inhibition of human plasma cholinesterase (ChE) and erythrocyte acetylcholinesterase (AChE) by alcuronium, atracurium, d-tubocurarine, pancuronium, pipecuronium, and vecuronium were studied in blood drawn from 35 surgical patients. Atracurium 136-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 14564607-1 2000 PURPOSE: The kinetics of the inhibition of human plasma cholinesterase (ChE) and erythrocyte acetylcholinesterase (AChE) by alcuronium, atracurium, d-tubocurarine, pancuronium, pipecuronium, and vecuronium were studied in blood drawn from 35 surgical patients. Atracurium 136-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 14564607-1 2000 PURPOSE: The kinetics of the inhibition of human plasma cholinesterase (ChE) and erythrocyte acetylcholinesterase (AChE) by alcuronium, atracurium, d-tubocurarine, pancuronium, pipecuronium, and vecuronium were studied in blood drawn from 35 surgical patients. Tubocurarine 148-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 14564607-1 2000 PURPOSE: The kinetics of the inhibition of human plasma cholinesterase (ChE) and erythrocyte acetylcholinesterase (AChE) by alcuronium, atracurium, d-tubocurarine, pancuronium, pipecuronium, and vecuronium were studied in blood drawn from 35 surgical patients. Pancuronium 164-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 14564607-1 2000 PURPOSE: The kinetics of the inhibition of human plasma cholinesterase (ChE) and erythrocyte acetylcholinesterase (AChE) by alcuronium, atracurium, d-tubocurarine, pancuronium, pipecuronium, and vecuronium were studied in blood drawn from 35 surgical patients. Pancuronium 164-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 14564607-1 2000 PURPOSE: The kinetics of the inhibition of human plasma cholinesterase (ChE) and erythrocyte acetylcholinesterase (AChE) by alcuronium, atracurium, d-tubocurarine, pancuronium, pipecuronium, and vecuronium were studied in blood drawn from 35 surgical patients. Pipecuronium 177-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 14564607-1 2000 PURPOSE: The kinetics of the inhibition of human plasma cholinesterase (ChE) and erythrocyte acetylcholinesterase (AChE) by alcuronium, atracurium, d-tubocurarine, pancuronium, pipecuronium, and vecuronium were studied in blood drawn from 35 surgical patients. Vecuronium Bromide 195-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 14564607-2 2000 METHODS: The activities of plasma ChE and erythrocyte AChE were determined by the calorimetric method of Ellman et al., using acetylthiocholine as the substrate. Acetylthiocholine 126-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 14564607-4 2000 RESULTS: The dissociation constants (K(m)) of plasma ChE and erythrocyte AChE were 5.00 x 10(-5) M and 5.28 x 10(-5) M, respectively, indicating that both enzymes have similar affinity to acetylthiocholine. Acetylthiocholine 188-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 14564607-6 2000 The apparent inhibition constants (K(i)) of pancuronium (8.72 x 10(-8) M) and vecuronium (3.53 x 10(-7) M) for plasma ChE inhibition were lower than that of neostigmine (7.36 x 10(-7) M), whereas those of the six nondepolarizing NMBAs for erythrocyte AChE were markedly higher than that of neostigmine. Pancuronium 44-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 251-255 14564607-6 2000 The apparent inhibition constants (K(i)) of pancuronium (8.72 x 10(-8) M) and vecuronium (3.53 x 10(-7) M) for plasma ChE inhibition were lower than that of neostigmine (7.36 x 10(-7) M), whereas those of the six nondepolarizing NMBAs for erythrocyte AChE were markedly higher than that of neostigmine. Vecuronium Bromide 78-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 251-255 11261808-2 2000 Originally established as a reversible inhibitor of the acetylcholine-degrading enzyme acetylcholinesterase (AChE), galantamine also acts as an allosterically potentiating ligand (APL) on nicotinic acetylcholine receptors (nAChR). Galantamine 116-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 10718203-5 2000 Metrifonate produced a mean erythrocyte acetylcholinesterase inhibition at the end of treatment of 86.3%. Trichlorfon 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 10718203-13 2000 This metrifonate dose provided a high level of acetylcholinesterase inhibition, which was associated in these patients with a favorable safety and tolerability profile. Trichlorfon 5-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 10679638-1 2000 A highly sensitive flow analysis method for determination of acetylcholinesterase (AChE) inhibitors like organophosphorous pesticides using a new chemiluminescent reaction was developed and optimized. organophosphorous 105-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 10679638-1 2000 A highly sensitive flow analysis method for determination of acetylcholinesterase (AChE) inhibitors like organophosphorous pesticides using a new chemiluminescent reaction was developed and optimized. organophosphorous 105-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 10679638-4 2000 Variations in enzyme activity due to inhibition are measured from the changes of concentrations of thiocholine produced when the substrate (acetylthiocholine chloride) is pumped before and after the passage of the solution containing the pesticide through the immobilized AChE reactor. Thiocholine 99-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 272-276 10679638-4 2000 Variations in enzyme activity due to inhibition are measured from the changes of concentrations of thiocholine produced when the substrate (acetylthiocholine chloride) is pumped before and after the passage of the solution containing the pesticide through the immobilized AChE reactor. Acetylthiocholine chloride 140-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 272-276 10733609-2 2000 3D quantitative structure-activity relationship (3D QSAR) models have been derived for a series of N-benzylpiperidine derivatives which are potent acetylcholinesterase (AChE) inhibitors interesting for Alzheimer"s disease. 1-benzylpiperidine 99-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 10733609-2 2000 3D quantitative structure-activity relationship (3D QSAR) models have been derived for a series of N-benzylpiperidine derivatives which are potent acetylcholinesterase (AChE) inhibitors interesting for Alzheimer"s disease. 1-benzylpiperidine 99-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 11140610-1 2000 In this study the authors attempt to correlate kinetic constants for carbamylation of AChE, by a series of carbamate inhibitors, with the conformational positioning of Trp84 in transition state complexes of the same carbamates with Torpedo AChE, as obtained by computerized molecular modelling. Carbamates 107-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 11140610-1 2000 In this study the authors attempt to correlate kinetic constants for carbamylation of AChE, by a series of carbamate inhibitors, with the conformational positioning of Trp84 in transition state complexes of the same carbamates with Torpedo AChE, as obtained by computerized molecular modelling. Carbamates 107-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 240-244 11140610-1 2000 In this study the authors attempt to correlate kinetic constants for carbamylation of AChE, by a series of carbamate inhibitors, with the conformational positioning of Trp84 in transition state complexes of the same carbamates with Torpedo AChE, as obtained by computerized molecular modelling. Carbamates 216-226 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 11140610-1 2000 In this study the authors attempt to correlate kinetic constants for carbamylation of AChE, by a series of carbamate inhibitors, with the conformational positioning of Trp84 in transition state complexes of the same carbamates with Torpedo AChE, as obtained by computerized molecular modelling. Carbamates 216-226 acetylcholinesterase (Cartwright blood group) Homo sapiens 240-244 11140610-4 2000 In conclusion, the value of the bimolecular rate constant for selected AChE inhibitors (structural changes that have been hypothesised or natural alkaloids of unknown activity) which possess similar size and rigidity, can be obtained. Alkaloids 146-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 11198060-1 2000 Donepezil is an acetylcholinesterase inhibitor indicated for the symptomatic treatment of mild to moderate Alzheimer"s disease. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 10791297-0 2000 The recovery of cerebrospinal fluid acetylcholinesterase activity in Alzheimer"s disease patients after treatment with metrifonate. Trichlorfon 119-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 12197070-0 2000 Identification of selective inhibitors of acetylcholinesterase from a combinatorial library of 2,5-piperazinediones. 2,5-dioxopiperazine 95-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 12197070-2 2000 Increasing the acetylcholine concentration in brain by modulating acetylcholinesterase (AChE) activity is among the most promising strategies. Acetylcholine 15-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 12197070-2 2000 Increasing the acetylcholine concentration in brain by modulating acetylcholinesterase (AChE) activity is among the most promising strategies. Acetylcholine 15-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 12197070-3 2000 We have used a combinatorial approach to identify different 2,5-piperazinediones (DKP) with AChE inhibitory activity. 2,5-dioxopiperazine 60-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 12197070-3 2000 We have used a combinatorial approach to identify different 2,5-piperazinediones (DKP) with AChE inhibitory activity. dkp 82-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 11068139-0 2000 Donepezil dose-dependently inhibits acetylcholinesterase activity in various areas and in the presynaptic cholinergic and the postsynaptic cholinoceptive enzyme-positive structures in the human and rat brain. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 10641971-2 2000 Tacrine and donepezil are classified as short-acting or reversible agents since binding to acetylcholinesterase enzyme (AChE) is hydrolyzed within minutes. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-118 10641971-2 2000 Tacrine and donepezil are classified as short-acting or reversible agents since binding to acetylcholinesterase enzyme (AChE) is hydrolyzed within minutes. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 10641971-2 2000 Tacrine and donepezil are classified as short-acting or reversible agents since binding to acetylcholinesterase enzyme (AChE) is hydrolyzed within minutes. Donepezil 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-118 10641971-2 2000 Tacrine and donepezil are classified as short-acting or reversible agents since binding to acetylcholinesterase enzyme (AChE) is hydrolyzed within minutes. Donepezil 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 10641971-3 2000 Rivastigmine is classified as an intermediate-acting or pseudo-irreversible agent due to its long inhibition on AChE of up to 10 hours. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 10771584-22 2000 OPs exert their insecticidal action by their ability to inhibit AChE at the cholinergic synapse, resulting in the accumulation of acetylcholine. Acetylcholine 130-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 10900685-5 2000 A significant correlation was found between AChE activity and the level of the primary products of oxidation in blood erythrocytes of AD patients before and after therapy with amiridine and gliatiline. amiridine 176-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 10900685-5 2000 A significant correlation was found between AChE activity and the level of the primary products of oxidation in blood erythrocytes of AD patients before and after therapy with amiridine and gliatiline. gliatiline 190-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 10632139-0 1999 Paraoxonase and acetylcholinesterase activities in humans exposed to organophosphorous compounds. organophosphorous compounds 69-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 10585885-2 1999 It is thus located on the outer surface of the schistosomal tegument and is most probably analogous to the glycosylphosphatidylinositol-anchored G(2) form of acetylcholinesterase found in the electric organ of Torpedo, on the surface of mammalian erythrocytes, and elsewhere. Glycosylphosphatidylinositols 107-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-178 10585885-5 1999 The bound acetylcholinesterase could be progressively eluted by increasing the salt concentration, with approx. Salts 79-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-30 10585885-7 1999 Selective inhibition experiments carried out on live parasites using the covalent acetylcholinesterase inhibitor echothiophate (phospholine), which does not penetrate the tegument, selectively inhibited the 6.5 S form, but not the 8 S form, suggesting an internal location for the latter. phospholine 113-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 10585885-7 1999 Selective inhibition experiments carried out on live parasites using the covalent acetylcholinesterase inhibitor echothiophate (phospholine), which does not penetrate the tegument, selectively inhibited the 6.5 S form, but not the 8 S form, suggesting an internal location for the latter. phospholine 128-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 10602696-1 1999 The binding of the 9-methyl derivative of tacrine-huperzine A hybrid to Torpedo californica acetylcholinesterase (AChE) has been studied by computational methods. methyl radical 21-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 10602696-1 1999 The binding of the 9-methyl derivative of tacrine-huperzine A hybrid to Torpedo californica acetylcholinesterase (AChE) has been studied by computational methods. Tacrine 42-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 10602696-1 1999 The binding of the 9-methyl derivative of tacrine-huperzine A hybrid to Torpedo californica acetylcholinesterase (AChE) has been studied by computational methods. huperzine A 50-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 10602696-6 1999 Finally, we have also investigated the effect of replacing Phe300 in the Torpedo californica enzyme by Tyr, which is present in the human AChE. Tyrosine 103-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 10602696-8 1999 Overall, the whole of results supports the validity of the putative binding model to explain the binding of tacrine-huperzine A hybrids to AChE. Tacrine 108-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 10602696-8 1999 Overall, the whole of results supports the validity of the putative binding model to explain the binding of tacrine-huperzine A hybrids to AChE. huperzine A 116-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 10612585-0 1999 Synthesis and acetylcholinesterase inhibitory activity of huperzine A-E2020 combined compound. huperzine a-e2020 58-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 10612585-1 1999 The synthesis of huperzine-E2020 combined compound (3) has been accomplished and the activities of 3 and the intermediates 12 and 13 to inhibit the activity of acetylcholinesterase have been measured. huperzine A 17-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-180 10641290-1 1999 Part I: Immobilization, characterization and stabilization of acetylcholinesterase and organophosphate hydrolase on silica supports. Silicon Dioxide 116-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 10641290-2 1999 Biosensors for organophosphates in solution may be constructed by monitoring the activity of acetylcholinesterase (AChE) or organophosphate hydrolase (OPH) immobilized to a variety of microsensor platforms. Organophosphates 15-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 10641290-2 1999 Biosensors for organophosphates in solution may be constructed by monitoring the activity of acetylcholinesterase (AChE) or organophosphate hydrolase (OPH) immobilized to a variety of microsensor platforms. Organophosphates 15-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 10641290-7 1999 Two different covalent chemistries were used to immobilize AChE and OPH to these porous and non-porous silica beads. Silicon Dioxide 103-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 10587286-9 1999 Inhibition of AChE in the CSF after rivastigmine administration was significantly greater than after placebo for up to 8.4 hours after the dose and was maximal (40%) at 2.4 hours. Rivastigmine 36-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 10587286-12 1999 This study confirms the feasibility of using continuous measurement of AChE activity in CSF over prolonged periods, that rivastigmine markedly inhibits CSF AChE after a single oral dose of 3 mg, and that the inhibition of central AChE is substantially greater than that of peripheral AChE or BuChE. Rivastigmine 121-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-160 10587286-12 1999 This study confirms the feasibility of using continuous measurement of AChE activity in CSF over prolonged periods, that rivastigmine markedly inhibits CSF AChE after a single oral dose of 3 mg, and that the inhibition of central AChE is substantially greater than that of peripheral AChE or BuChE. Rivastigmine 121-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-160 10587286-12 1999 This study confirms the feasibility of using continuous measurement of AChE activity in CSF over prolonged periods, that rivastigmine markedly inhibits CSF AChE after a single oral dose of 3 mg, and that the inhibition of central AChE is substantially greater than that of peripheral AChE or BuChE. Rivastigmine 121-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-160 10570064-4 1999 The lactone form of CPT-11 resulted in apparent noncompetitive inhibition of electric eel and both human recombinant and erythrocyte AChE with K(i) values of 0.065, 0.19, and 0.29 microM, respectively. Lactones 4-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 10570064-11 1999 Also, preliminary molecular modeling of the interaction between AChE and CPT-11 indicated that the latter does not bind at the same site as tacrine. Irinotecan 73-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 10570064-13 1999 The rapid reversibility of the inhibition of AChE by CPT-11 and the lower activity of the carboxylate form are likely reasons for the transient nature of the cholinergic toxicity observed clinically. Irinotecan 53-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 10634129-8 1999 To inhibit cholinesterases, O-demethylgalanthamine was 10-fold more selective for acetylcholinesterase (AChE) versus butyrylcholinesterase (BuChE) than galanthamine. demethylgalanthamine 30-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 10634129-8 1999 To inhibit cholinesterases, O-demethylgalanthamine was 10-fold more selective for acetylcholinesterase (AChE) versus butyrylcholinesterase (BuChE) than galanthamine. demethylgalanthamine 30-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 10634129-8 1999 To inhibit cholinesterases, O-demethylgalanthamine was 10-fold more selective for acetylcholinesterase (AChE) versus butyrylcholinesterase (BuChE) than galanthamine. Galantamine 38-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 10634129-8 1999 To inhibit cholinesterases, O-demethylgalanthamine was 10-fold more selective for acetylcholinesterase (AChE) versus butyrylcholinesterase (BuChE) than galanthamine. Galantamine 38-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 10794404-19 2000 The results of the forensic studies showed that methylphosphonic acid, the hydrolysis product of sarin, bound to AChE in the cerebellums of the victims was separated and identified using GCMS. methylphosphonic acid 48-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 11068139-1 2000 In the symptomatic treatment of mild to moderately severe dementia associated with Alzheimer"s disease, donepezil (E2020) has been introduced for the inhibition of acetylcholinesterase activity in the human brain. Donepezil 115-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-184 11068139-3 2000 This study demonstrates by histochemical means that donepezil exerts a dose-dependent inhibitory effect in vitro on acetylcholinesterase activity. Donepezil 52-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 11068139-7 2000 In the hippocampus, the axonal acetylcholinesterase reaction end-product was eliminated by 5 x 10(-7)M donepezil. Donepezil 103-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 11068139-10 2000 These histochemical results provide the first morphological evidence that, under in vitro circumstances, donepezil is not a general acetylcholinesterase inhibitor in the CNS, but rather selectively affects the different brain areas and, within these, the cholinoceptive and cholinergic structures. Donepezil 105-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-152 11068139-11 2000 The acetylcholinesterase staining in the nerve fibers (innervating the intracerebral blood vessels of the human brain and the extracerebral blood vessels of the rat brain) and at the neuromuscular junction in the diaphragm and gastrocnemius muscle of rat, was also inhibited dose dependently by donepezil. Donepezil 295-304 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 11068139-12 2000 It is concluded that donepezil may be a valuable tool with which to influence both the pre- and the postsynaptic acetylcholinesterase-positive structures in the human and rat central and peripheral nervous systems. Donepezil 21-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-133 11068139-1 2000 In the symptomatic treatment of mild to moderately severe dementia associated with Alzheimer"s disease, donepezil (E2020) has been introduced for the inhibition of acetylcholinesterase activity in the human brain. Donepezil 104-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-184 10619655-1 1999 Acetylcholinesterase (AChE) catalyses the hydrolysis of the neurotransmitter acetylcholine and it has been implicated in several non-cholinergic actions, including neurite outgrowth and amyloid formation. Acetylcholine 77-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 10619655-4 1999 The action of AChE was not affected by edrophonium and tacrine both active site inhibitors, but it was abolished by propidium and gallamine, two peripheral anionic binding site (PAS) ligands. Gallamine Triethiodide 130-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 10619655-1 1999 Acetylcholinesterase (AChE) catalyses the hydrolysis of the neurotransmitter acetylcholine and it has been implicated in several non-cholinergic actions, including neurite outgrowth and amyloid formation. Acetylcholine 77-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 10619655-4 1999 The action of AChE was not affected by edrophonium and tacrine both active site inhibitors, but it was abolished by propidium and gallamine, two peripheral anionic binding site (PAS) ligands. Aminosalicylic Acid 178-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 10619655-3 1999 Low AChE concentrations (0.1-2.5 nM) stimulated neurite outgrowth and induced cell proliferation as measured by MTT reduction and [3H]thymidine incorporation. monooxyethylene trimethylolpropane tristearate 112-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 10619655-5 1999 We conclude that the PAS domain of AChE is involved in the neurotrophic activity of the enzyme. Aminosalicylic Acid 21-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 10619655-3 1999 Low AChE concentrations (0.1-2.5 nM) stimulated neurite outgrowth and induced cell proliferation as measured by MTT reduction and [3H]thymidine incorporation. Tritium 131-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 10619655-3 1999 Low AChE concentrations (0.1-2.5 nM) stimulated neurite outgrowth and induced cell proliferation as measured by MTT reduction and [3H]thymidine incorporation. Thymidine 134-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 10619655-4 1999 The action of AChE was not affected by edrophonium and tacrine both active site inhibitors, but it was abolished by propidium and gallamine, two peripheral anionic binding site (PAS) ligands. Edrophonium 39-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 10619655-4 1999 The action of AChE was not affected by edrophonium and tacrine both active site inhibitors, but it was abolished by propidium and gallamine, two peripheral anionic binding site (PAS) ligands. Tacrine 55-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 10619655-4 1999 The action of AChE was not affected by edrophonium and tacrine both active site inhibitors, but it was abolished by propidium and gallamine, two peripheral anionic binding site (PAS) ligands. Propidium 116-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 10622674-8 1999 A number of preliminary studies, whose results are summarized here, have demonstrated that the use of the acetylcholinesterase inhibitors tacrine, metrifonate and donepezil, and the glial cell modulator, propentofylline, results in reductions in the overall costs of care. Tacrine 138-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 10632067-0 1999 Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities. 4-Aminopyridine 30-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 10632067-0 1999 Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities. 4-aminoquinoline 51-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 10632067-0 1999 Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities. alkylene 123-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 10632067-1 1999 Three series of 4-aminopyridine-and 4-aminoquinoline based symmetrical bivalent acetylcholinesterase (AChE) inhibitors were prepared and compared to previously synthesized dimers of 9-amino-1,2,3,4-tetrahydroacridine (tacrine). 4-aminopyridine-and 4-aminoquinoline 16-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 10632067-1 1999 Three series of 4-aminopyridine-and 4-aminoquinoline based symmetrical bivalent acetylcholinesterase (AChE) inhibitors were prepared and compared to previously synthesized dimers of 9-amino-1,2,3,4-tetrahydroacridine (tacrine). 4-aminopyridine-and 4-aminoquinoline 16-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 10622674-8 1999 A number of preliminary studies, whose results are summarized here, have demonstrated that the use of the acetylcholinesterase inhibitors tacrine, metrifonate and donepezil, and the glial cell modulator, propentofylline, results in reductions in the overall costs of care. Trichlorfon 147-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 10622674-8 1999 A number of preliminary studies, whose results are summarized here, have demonstrated that the use of the acetylcholinesterase inhibitors tacrine, metrifonate and donepezil, and the glial cell modulator, propentofylline, results in reductions in the overall costs of care. Donepezil 163-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 10622674-8 1999 A number of preliminary studies, whose results are summarized here, have demonstrated that the use of the acetylcholinesterase inhibitors tacrine, metrifonate and donepezil, and the glial cell modulator, propentofylline, results in reductions in the overall costs of care. propentofylline 204-219 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 11249555-5 1999 Experimentally, donepezil inhibits AChE activity in human erythrocytes and increases extracellular acetylcholine levels in the cerebral cortex and the hippocampus of the rat. Donepezil 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 10585525-4 1999 Microdialysis was performed with a Ringer containing low concentrations (0.01 microM) of the acetylcholinesterase inhibitor, neostigmine. Neostigmine 125-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 10530519-4 1999 The AChE dimers and monomers remained amphiphilic after incubation with phosphatidylinositol-specific phospholipase C (PIPLC), after or without prior treatment with alkaline hydroxylamine, which shows that, in contrast to the meningioma AChE dimers and monomers, the neurinoma isoforms are devoid of glycolipid. Phosphatidylinositols 72-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 10530519-4 1999 The AChE dimers and monomers remained amphiphilic after incubation with phosphatidylinositol-specific phospholipase C (PIPLC), after or without prior treatment with alkaline hydroxylamine, which shows that, in contrast to the meningioma AChE dimers and monomers, the neurinoma isoforms are devoid of glycolipid. Phosphatidylinositols 72-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 237-241 10530519-4 1999 The AChE dimers and monomers remained amphiphilic after incubation with phosphatidylinositol-specific phospholipase C (PIPLC), after or without prior treatment with alkaline hydroxylamine, which shows that, in contrast to the meningioma AChE dimers and monomers, the neurinoma isoforms are devoid of glycolipid. alkaline hydroxylamine 165-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 10530519-4 1999 The AChE dimers and monomers remained amphiphilic after incubation with phosphatidylinositol-specific phospholipase C (PIPLC), after or without prior treatment with alkaline hydroxylamine, which shows that, in contrast to the meningioma AChE dimers and monomers, the neurinoma isoforms are devoid of glycolipid. alkaline hydroxylamine 165-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 237-241 10530519-4 1999 The AChE dimers and monomers remained amphiphilic after incubation with phosphatidylinositol-specific phospholipase C (PIPLC), after or without prior treatment with alkaline hydroxylamine, which shows that, in contrast to the meningioma AChE dimers and monomers, the neurinoma isoforms are devoid of glycolipid. Glycolipids 300-310 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 10514292-1 1999 Dimeric acetylcholinesterase (AChE) inhibitors containing a single 9-amino-1,2,3,4-tetrahydroacridine (tacrine) unit were constructed in an effort to further delineate structural requirements for optimal binding to the AChE peripheral site. Tacrine 67-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-28 10514292-1 1999 Dimeric acetylcholinesterase (AChE) inhibitors containing a single 9-amino-1,2,3,4-tetrahydroacridine (tacrine) unit were constructed in an effort to further delineate structural requirements for optimal binding to the AChE peripheral site. Tacrine 67-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 10514292-1 1999 Dimeric acetylcholinesterase (AChE) inhibitors containing a single 9-amino-1,2,3,4-tetrahydroacridine (tacrine) unit were constructed in an effort to further delineate structural requirements for optimal binding to the AChE peripheral site. Tacrine 103-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-28 10514292-1 1999 Dimeric acetylcholinesterase (AChE) inhibitors containing a single 9-amino-1,2,3,4-tetrahydroacridine (tacrine) unit were constructed in an effort to further delineate structural requirements for optimal binding to the AChE peripheral site. Tacrine 103-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 10514292-3 1999 AChE IC(50) values of the optimum dimers decrease significantly as the peripheral site ligand was permuted in the series ammonia > dimethylamine > 4-aminopyridine > 4-aminoquinoline > tacrine. dimethylamine 134-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 10514292-3 1999 AChE IC(50) values of the optimum dimers decrease significantly as the peripheral site ligand was permuted in the series ammonia > dimethylamine > 4-aminopyridine > 4-aminoquinoline > tacrine. 4-Aminopyridine 153-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 10514292-3 1999 AChE IC(50) values of the optimum dimers decrease significantly as the peripheral site ligand was permuted in the series ammonia > dimethylamine > 4-aminopyridine > 4-aminoquinoline > tacrine. 4-aminoquinoline 174-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 10514292-3 1999 AChE IC(50) values of the optimum dimers decrease significantly as the peripheral site ligand was permuted in the series ammonia > dimethylamine > 4-aminopyridine > 4-aminoquinoline > tacrine. Tacrine 196-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 10529460-1 1999 Determination of erythrocyte acetylcholinesterase (AChE) activity is the appropriate tool for the diagnosis of organophosphate exposure and intoxication. Organophosphates 111-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 10529460-1 1999 Determination of erythrocyte acetylcholinesterase (AChE) activity is the appropriate tool for the diagnosis of organophosphate exposure and intoxication. Organophosphates 111-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 10529460-6 1999 AChE activity was determined in whole blood samples in the presence of the selective butyrylcholinesterase inhibitor ethopropazine. profenamine 117-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 10529460-9 1999 This modified approach provides a simple way for sensitive and precise determination of AChE activity in whole blood in the presence of organophosphates even with low-tech equipment. Organophosphates 136-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 11139819-0 1999 Rivastigmine, a brain-region selective acetylcholinesterase inhibitor for treating Alzheimer"s disease: review and current status. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 11139819-4 1999 Early acetylcholinesterase inhibitors, such as tacrine and physostigmine, are poorly tolerated and have a short duration of action. Tacrine 47-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-26 11139819-4 1999 Early acetylcholinesterase inhibitors, such as tacrine and physostigmine, are poorly tolerated and have a short duration of action. Physostigmine 59-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-26 11139819-5 1999 Rivastigmine is a centrally-selective acetylcholinesterase inhibitor with a relatively long duration of action and is a "pseudo-irreversible" cholinesterase inhibitor due to slow dissociation of a carbamoyl derivative from the esteratic site of acetylcholinesterase. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 11139819-5 1999 Rivastigmine is a centrally-selective acetylcholinesterase inhibitor with a relatively long duration of action and is a "pseudo-irreversible" cholinesterase inhibitor due to slow dissociation of a carbamoyl derivative from the esteratic site of acetylcholinesterase. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 245-265 10532640-8 1999 The authors conclude that the optimal analysis method for [11C]PMP differs as a function of AChE activity. UNII-S4X91EGA07 58-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 11249555-3 1999 Donepezil is a piperidine based, potent, specific, non-competitive and reversible inhibitor of acetylcholinesterase (AChE). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 11249555-3 1999 Donepezil is a piperidine based, potent, specific, non-competitive and reversible inhibitor of acetylcholinesterase (AChE). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 11249555-3 1999 Donepezil is a piperidine based, potent, specific, non-competitive and reversible inhibitor of acetylcholinesterase (AChE). piperidine 15-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 11249555-3 1999 Donepezil is a piperidine based, potent, specific, non-competitive and reversible inhibitor of acetylcholinesterase (AChE). piperidine 15-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 10532640-0 1999 Kinetic modeling of N-[11C]methylpiperidin-4-yl propionate: alternatives for analysis of an irreversible positron emission tomography trace for measurement of acetylcholinesterase activity in human brain. n-[11c]methylpiperidin-4-yl propionate 20-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 10532640-1 1999 N-[11C]Methylpiperidin-4-yl propionate ([11C]PMP) is a substrate for hydrolysis by acetylcholinesterase (AChE). n-[11c]methylpiperidin-4-yl propionate 0-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 10532640-1 1999 N-[11C]Methylpiperidin-4-yl propionate ([11C]PMP) is a substrate for hydrolysis by acetylcholinesterase (AChE). n-[11c]methylpiperidin-4-yl propionate 0-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 10532640-1 1999 N-[11C]Methylpiperidin-4-yl propionate ([11C]PMP) is a substrate for hydrolysis by acetylcholinesterase (AChE). UNII-S4X91EGA07 40-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 10532640-1 1999 N-[11C]Methylpiperidin-4-yl propionate ([11C]PMP) is a substrate for hydrolysis by acetylcholinesterase (AChE). UNII-S4X91EGA07 40-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 10520506-0 1999 [Huperzine a: an acetylcholinesterase inhibitor with high pharmacological potential]. huperzine A 1-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 10491113-1 1999 Apart from its catalytic function in hydrolyzing acetylcholine, acetylcholinesterase (AChE) affects cell proliferation, differentiation and responses to various insults, including stress. Acetylcholine 49-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 10491113-1 1999 Apart from its catalytic function in hydrolyzing acetylcholine, acetylcholinesterase (AChE) affects cell proliferation, differentiation and responses to various insults, including stress. Acetylcholine 49-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 10499750-1 1999 BACKGROUND AND OBJECTIVES: The acetylcholinesterase inhibitor neostigmine has shown peripherally mediated analgesic action in recent preclinical and clinical studies. Neostigmine 62-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 10471290-0 1999 Targeted cross-linking of a molten globule form of acetylcholinesterase by the virucidal agent hypericin. hypericin 95-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 10471290-4 1999 We here demonstrate that hypericin binds to a molten globule species generated from Torpedo acetylcholinesterase, but not to the corresponding native enzyme. hypericin 25-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 10471290-7 1999 This agrees with our observation, using spin traps, that mainly singlet oxygen is produced by the complex of hypericin with the molten globule of acetylcholinesterase. Oxygen 72-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-166 10471290-7 1999 This agrees with our observation, using spin traps, that mainly singlet oxygen is produced by the complex of hypericin with the molten globule of acetylcholinesterase. hypericin 109-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-166 10433700-0 1999 Phosphoryl oxime inhibition of acetylcholinesterase during oxime reactivation is prevented by edrophonium. Oximes 11-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 10433700-0 1999 Phosphoryl oxime inhibition of acetylcholinesterase during oxime reactivation is prevented by edrophonium. Oximes 59-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 10433700-0 1999 Phosphoryl oxime inhibition of acetylcholinesterase during oxime reactivation is prevented by edrophonium. Edrophonium 94-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 10433700-1 1999 Reactivation of organophosphate (OP)-inhibited acetylcholinesterase (AChE) is a key objective in the treatment of OP poisoning. Organophosphates 16-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 10433700-1 1999 Reactivation of organophosphate (OP)-inhibited acetylcholinesterase (AChE) is a key objective in the treatment of OP poisoning. Organophosphates 16-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 10433700-2 1999 This study with native, wild-type, and mutant recombinant DNA-expressed AChEs, each inhibited by representative OP compounds, establishes a relationship between edrophonium acceleration of oxime-induced reactivation of OP-AChE conjugates and phosphoryl oxime inhibition of the reactivated enzyme that occurs during reactivation by pyridinium oximes LuH6 and TMB4. Edrophonium 161-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 10433700-2 1999 This study with native, wild-type, and mutant recombinant DNA-expressed AChEs, each inhibited by representative OP compounds, establishes a relationship between edrophonium acceleration of oxime-induced reactivation of OP-AChE conjugates and phosphoryl oxime inhibition of the reactivated enzyme that occurs during reactivation by pyridinium oximes LuH6 and TMB4. Oximes 189-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 10433700-2 1999 This study with native, wild-type, and mutant recombinant DNA-expressed AChEs, each inhibited by representative OP compounds, establishes a relationship between edrophonium acceleration of oxime-induced reactivation of OP-AChE conjugates and phosphoryl oxime inhibition of the reactivated enzyme that occurs during reactivation by pyridinium oximes LuH6 and TMB4. Oximes 253-258 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 10433700-2 1999 This study with native, wild-type, and mutant recombinant DNA-expressed AChEs, each inhibited by representative OP compounds, establishes a relationship between edrophonium acceleration of oxime-induced reactivation of OP-AChE conjugates and phosphoryl oxime inhibition of the reactivated enzyme that occurs during reactivation by pyridinium oximes LuH6 and TMB4. pyridinium oximes 331-348 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 10433700-2 1999 This study with native, wild-type, and mutant recombinant DNA-expressed AChEs, each inhibited by representative OP compounds, establishes a relationship between edrophonium acceleration of oxime-induced reactivation of OP-AChE conjugates and phosphoryl oxime inhibition of the reactivated enzyme that occurs during reactivation by pyridinium oximes LuH6 and TMB4. OBIDOXIME CHLORIDE 349-353 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 10433700-2 1999 This study with native, wild-type, and mutant recombinant DNA-expressed AChEs, each inhibited by representative OP compounds, establishes a relationship between edrophonium acceleration of oxime-induced reactivation of OP-AChE conjugates and phosphoryl oxime inhibition of the reactivated enzyme that occurs during reactivation by pyridinium oximes LuH6 and TMB4. Trimedoxime 358-362 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 10433700-4 1999 Phosphoryl oximes formed during reactivation of the ethoxy methylphosphonyl-AChE conjugate by LuH6 and TMB4 were isolated for the first time and their structures confirmed by (31)P NMR. phosphoryl oximes 0-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 10433700-4 1999 Phosphoryl oximes formed during reactivation of the ethoxy methylphosphonyl-AChE conjugate by LuH6 and TMB4 were isolated for the first time and their structures confirmed by (31)P NMR. ethoxy methylphosphonyl 52-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 10433700-4 1999 Phosphoryl oximes formed during reactivation of the ethoxy methylphosphonyl-AChE conjugate by LuH6 and TMB4 were isolated for the first time and their structures confirmed by (31)P NMR. OBIDOXIME CHLORIDE 94-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 10433700-4 1999 Phosphoryl oximes formed during reactivation of the ethoxy methylphosphonyl-AChE conjugate by LuH6 and TMB4 were isolated for the first time and their structures confirmed by (31)P NMR. Trimedoxime 103-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 10433700-5 1999 However, phosphoryl oximes formed during the reactivation of the diethylphosphoryl-AChE conjugate were not sufficiently stable to be detected by (31)P NMR. Oximes 20-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 10433700-6 1999 The purified ethoxy methylphosphonyl oximes formed during the reactivation of ethoxy methylphosphonyl-AChE conjugate with LuH6 and TMB4 are 10- to 22-fold more potent than MEPQ as inhibitors of AChE and stable for several hours at pH 7.2 in HEPES buffer. ethoxy methylphosphonyl oximes 13-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 10433700-6 1999 The purified ethoxy methylphosphonyl oximes formed during the reactivation of ethoxy methylphosphonyl-AChE conjugate with LuH6 and TMB4 are 10- to 22-fold more potent than MEPQ as inhibitors of AChE and stable for several hours at pH 7.2 in HEPES buffer. ethoxy methylphosphonyl oximes 13-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 194-198 10433700-6 1999 The purified ethoxy methylphosphonyl oximes formed during the reactivation of ethoxy methylphosphonyl-AChE conjugate with LuH6 and TMB4 are 10- to 22-fold more potent than MEPQ as inhibitors of AChE and stable for several hours at pH 7.2 in HEPES buffer. ethoxy methylphosphonyl 13-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 10433700-6 1999 The purified ethoxy methylphosphonyl oximes formed during the reactivation of ethoxy methylphosphonyl-AChE conjugate with LuH6 and TMB4 are 10- to 22-fold more potent than MEPQ as inhibitors of AChE and stable for several hours at pH 7.2 in HEPES buffer. ethoxy methylphosphonyl 13-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 194-198 10433700-6 1999 The purified ethoxy methylphosphonyl oximes formed during the reactivation of ethoxy methylphosphonyl-AChE conjugate with LuH6 and TMB4 are 10- to 22-fold more potent than MEPQ as inhibitors of AChE and stable for several hours at pH 7.2 in HEPES buffer. OBIDOXIME CHLORIDE 122-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 10433700-6 1999 The purified ethoxy methylphosphonyl oximes formed during the reactivation of ethoxy methylphosphonyl-AChE conjugate with LuH6 and TMB4 are 10- to 22-fold more potent than MEPQ as inhibitors of AChE and stable for several hours at pH 7.2 in HEPES buffer. OBIDOXIME CHLORIDE 122-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 194-198 10433700-6 1999 The purified ethoxy methylphosphonyl oximes formed during the reactivation of ethoxy methylphosphonyl-AChE conjugate with LuH6 and TMB4 are 10- to 22-fold more potent than MEPQ as inhibitors of AChE and stable for several hours at pH 7.2 in HEPES buffer. Trimedoxime 131-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 10433700-6 1999 The purified ethoxy methylphosphonyl oximes formed during the reactivation of ethoxy methylphosphonyl-AChE conjugate with LuH6 and TMB4 are 10- to 22-fold more potent than MEPQ as inhibitors of AChE and stable for several hours at pH 7.2 in HEPES buffer. Trimedoxime 131-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 194-198 10433700-6 1999 The purified ethoxy methylphosphonyl oximes formed during the reactivation of ethoxy methylphosphonyl-AChE conjugate with LuH6 and TMB4 are 10- to 22-fold more potent than MEPQ as inhibitors of AChE and stable for several hours at pH 7.2 in HEPES buffer. mepq 172-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 10433700-6 1999 The purified ethoxy methylphosphonyl oximes formed during the reactivation of ethoxy methylphosphonyl-AChE conjugate with LuH6 and TMB4 are 10- to 22-fold more potent than MEPQ as inhibitors of AChE and stable for several hours at pH 7.2 in HEPES buffer. mepq 172-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 194-198 10433700-6 1999 The purified ethoxy methylphosphonyl oximes formed during the reactivation of ethoxy methylphosphonyl-AChE conjugate with LuH6 and TMB4 are 10- to 22-fold more potent than MEPQ as inhibitors of AChE and stable for several hours at pH 7.2 in HEPES buffer. HEPES 241-246 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 10433700-7 1999 Reactivation of both ethoxy methylphosphonyl- and diethylphosphoryl-AChE by these two oximes was accelerated in the presence of rabbit serum paraoxonase, suggesting that organophosphorus hydrolase can hydrolyze phosphoryl oxime formed during the reactivation. Oximes 86-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 10433700-7 1999 Reactivation of both ethoxy methylphosphonyl- and diethylphosphoryl-AChE by these two oximes was accelerated in the presence of rabbit serum paraoxonase, suggesting that organophosphorus hydrolase can hydrolyze phosphoryl oxime formed during the reactivation. Oximes 86-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 10433700-8 1999 Our results emphasize that certain oximes, such as LuH6 and TMB4, if used in the treatment of OP pesticide poisoning may cause prolonged inhibition of AChE due to formation of phosphoryl oximes. Oximes 35-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 10433700-8 1999 Our results emphasize that certain oximes, such as LuH6 and TMB4, if used in the treatment of OP pesticide poisoning may cause prolonged inhibition of AChE due to formation of phosphoryl oximes. OBIDOXIME CHLORIDE 51-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 10433700-8 1999 Our results emphasize that certain oximes, such as LuH6 and TMB4, if used in the treatment of OP pesticide poisoning may cause prolonged inhibition of AChE due to formation of phosphoryl oximes. Trimedoxime 60-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 10433700-8 1999 Our results emphasize that certain oximes, such as LuH6 and TMB4, if used in the treatment of OP pesticide poisoning may cause prolonged inhibition of AChE due to formation of phosphoryl oximes. Oximes 187-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 10527884-3 1999 Whole AchE and the AchE recombinant catalytic subunit inhibited PMN superoxide anion (O2-) generation. Superoxides 68-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 10527884-3 1999 Whole AchE and the AchE recombinant catalytic subunit inhibited PMN superoxide anion (O2-) generation. Superoxides 68-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 10527884-3 1999 Whole AchE and the AchE recombinant catalytic subunit inhibited PMN superoxide anion (O2-) generation. Superoxides 86-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 10527884-3 1999 Whole AchE and the AchE recombinant catalytic subunit inhibited PMN superoxide anion (O2-) generation. Superoxides 86-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 10527884-4 1999 AchE synthetic peptides, residues 139-154 and 252-266 of the catalytic subunit, with sequence homology to that of the alpha3(IV) peptide also inhibited O2- production by PMN. Superoxides 152-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 10527884-6 1999 The data show that the non-collagenous domain of the AchE down-regulates O2- production by PMN. Superoxides 73-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 10414801-4 1999 At paraoxon concentrations > 0.1 microM obidoxime only partially reactivated acetylcholinesterase (AChE) of erythrocytes in vivo although reactivation could be assessed in vitro, which roughly fitted theoretical calculations. Obidoxime Chloride 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 10414801-4 1999 At paraoxon concentrations > 0.1 microM obidoxime only partially reactivated acetylcholinesterase (AChE) of erythrocytes in vivo although reactivation could be assessed in vitro, which roughly fitted theoretical calculations. Obidoxime Chloride 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 10329459-2 1999 We have observed that the specific acetylcholinesterase peripheral anionic site inhibitors, BW284c51 and propidium iodide, abrogated cell-substrate adhesion in three human neuroblastoma cell lines. Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide 92-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 10329459-2 1999 We have observed that the specific acetylcholinesterase peripheral anionic site inhibitors, BW284c51 and propidium iodide, abrogated cell-substrate adhesion in three human neuroblastoma cell lines. Propidium 105-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 10350622-0 1999 Optimising the signal peptide for glycosyl phosphatidylinositol modification of human acetylcholinesterase using mutational analysis and peptide-quantitative structure-activity relationships. Glycosylphosphatidylinositols 34-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 10321902-4 1999 Bromine activation resulted in greater AChE inhibition than that produced by RLM activation for equivalent concentrations of fenitrothion, malathion, and EPN. Bromine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 10321902-4 1999 Bromine activation resulted in greater AChE inhibition than that produced by RLM activation for equivalent concentrations of fenitrothion, malathion, and EPN. Fenitrothion 125-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 10321902-4 1999 Bromine activation resulted in greater AChE inhibition than that produced by RLM activation for equivalent concentrations of fenitrothion, malathion, and EPN. Malathion 139-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 10321902-9 1999 AChE of hen brain homogenates was also more sensitive than homogenates from other species to malaoxon, the active form of malathion. malaoxon 93-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 10321902-9 1999 AChE of hen brain homogenates was also more sensitive than homogenates from other species to malaoxon, the active form of malathion. Malathion 122-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 10421442-4 1999 We also report here that acetylthiocholine can bind to the AChE peripheral site with an equilibrium dissociation constant K(S) of about 1 mM. Acetylthiocholine 25-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 10421442-8 1999 Organophosphates equilibrate with AChE prior to phosphorylating the active site serine residue, and as predicted propidium had little effect on the phosphorylation rate constants for the fluorogenic organophosphate ethylmethyl-phosphonylcoumarin (EMPC). Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 10421442-10 1999 In contrast to propidium, when the neurotoxin fasciculin bound to the AChE peripheral site both a steric blockade and a conformational change in the acylation site appeared to occur. Propidium 15-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 10421451-0 1999 3-Hydroxyquinuclidinium derivatives: synthesis of compounds and inhibition of acetylcholinesterase. 3-hydroxyquinuclidinium 0-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 10421473-5 1999 Organophosphates being long-acting active site inhibitors of AChE were chosen for this study. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 10421494-2 1999 This enzyme has proved to be an excellent tool for the assessment of neuropathic potential of organophosphates (OP), in particular by comparison of an OP inhibitory activity in vitro against NTE and acetylcholinesterase. Organophosphates 94-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-219 10340306-0 1999 Phenylmethylsulfonyl fluoride inhibitory effects on acetylcholinesterase of brain and muscle. Phenylmethylsulfonyl Fluoride 0-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 10340306-1 1999 Differential inhibition of brain versus peripheral acetylcholinesterase (AChE) by phenylmethylsulfonyl fluoride (PMSF) suggested that PMSF might preferentially inhibit different AChE molecular forms. Phenylmethylsulfonyl Fluoride 82-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 10340306-1 1999 Differential inhibition of brain versus peripheral acetylcholinesterase (AChE) by phenylmethylsulfonyl fluoride (PMSF) suggested that PMSF might preferentially inhibit different AChE molecular forms. Phenylmethylsulfonyl Fluoride 82-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 10340306-1 1999 Differential inhibition of brain versus peripheral acetylcholinesterase (AChE) by phenylmethylsulfonyl fluoride (PMSF) suggested that PMSF might preferentially inhibit different AChE molecular forms. Phenylmethylsulfonyl Fluoride 82-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-182 10340306-1 1999 Differential inhibition of brain versus peripheral acetylcholinesterase (AChE) by phenylmethylsulfonyl fluoride (PMSF) suggested that PMSF might preferentially inhibit different AChE molecular forms. Phenylmethylsulfonyl Fluoride 113-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 10340306-1 1999 Differential inhibition of brain versus peripheral acetylcholinesterase (AChE) by phenylmethylsulfonyl fluoride (PMSF) suggested that PMSF might preferentially inhibit different AChE molecular forms. Phenylmethylsulfonyl Fluoride 113-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 10340306-1 1999 Differential inhibition of brain versus peripheral acetylcholinesterase (AChE) by phenylmethylsulfonyl fluoride (PMSF) suggested that PMSF might preferentially inhibit different AChE molecular forms. Phenylmethylsulfonyl Fluoride 134-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 10340306-1 1999 Differential inhibition of brain versus peripheral acetylcholinesterase (AChE) by phenylmethylsulfonyl fluoride (PMSF) suggested that PMSF might preferentially inhibit different AChE molecular forms. Phenylmethylsulfonyl Fluoride 134-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 10340306-1 1999 Differential inhibition of brain versus peripheral acetylcholinesterase (AChE) by phenylmethylsulfonyl fluoride (PMSF) suggested that PMSF might preferentially inhibit different AChE molecular forms. Phenylmethylsulfonyl Fluoride 134-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-182 10340306-9 1999 These results suggest that PMSF inhibition of AChE is a consequence of a selective inhibition of membrane-associated forms and that the apparent brain selectivity is related to the greater fraction of membrane-associated AChE in brain. Phenylmethylsulfonyl Fluoride 27-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 10340306-9 1999 These results suggest that PMSF inhibition of AChE is a consequence of a selective inhibition of membrane-associated forms and that the apparent brain selectivity is related to the greater fraction of membrane-associated AChE in brain. Phenylmethylsulfonyl Fluoride 27-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 221-225 10424771-2 1999 Diethylphosphoryl oximes (DEP-OX) that were generated in situ were demonstrated in the past to be unstable, yet were more potent inhibitors of acetylcholinesterase (AChE) than the parent OPs. diethylphosphoryloxime 0-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 10424771-2 1999 Diethylphosphoryl oximes (DEP-OX) that were generated in situ were demonstrated in the past to be unstable, yet were more potent inhibitors of acetylcholinesterase (AChE) than the parent OPs. diethylphosphoryloxime 0-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 10482456-3 1999 The current research was undertaken to produce an acetylcholinesterase inhibitor by employing 11-aminobenzoquinolizidines (4) and 10-aminobenzoindolizidines (5) as templates. 11-aminobenzoquinolizidines 94-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 10482456-3 1999 The current research was undertaken to produce an acetylcholinesterase inhibitor by employing 11-aminobenzoquinolizidines (4) and 10-aminobenzoindolizidines (5) as templates. 10-aminobenzoindolizidines 130-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 10474772-0 1999 Human erythrocyte but not brain acetylcholinesterase hydrolyses heroin to morphine. Heroin 64-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 10474772-0 1999 Human erythrocyte but not brain acetylcholinesterase hydrolyses heroin to morphine. Morphine 74-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 10474772-6 1999 In vitro, human erythrocyte acetylcholinesterase (AChE) hydrolyses heroin to 6-MAM, with a catalytic efficiency of 0.5/min per mumol/L under first-order kinetics. Heroin 67-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 10474772-6 1999 In vitro, human erythrocyte acetylcholinesterase (AChE) hydrolyses heroin to 6-MAM, with a catalytic efficiency of 0.5/min per mumol/L under first-order kinetics. Heroin 67-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 10474772-7 1999 Moreover, erythrocyte AChE, but not BuChE is capable of further hydrolysing 6-MAM to morphine, albeit at a considerably slower rate. Morphine 85-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 10474772-9 1999 Both hydrolysis steps by erythrocyte AChE were totally blocked by the selective AChE inhibitor BW284c51 but were not blocked by the BuChE-specific inhibitor, iso-OMPA (tetraisopropylpyrophosphoramide). Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide 95-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 10474772-9 1999 Both hydrolysis steps by erythrocyte AChE were totally blocked by the selective AChE inhibitor BW284c51 but were not blocked by the BuChE-specific inhibitor, iso-OMPA (tetraisopropylpyrophosphoramide). Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide 95-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 10474772-9 1999 Both hydrolysis steps by erythrocyte AChE were totally blocked by the selective AChE inhibitor BW284c51 but were not blocked by the BuChE-specific inhibitor, iso-OMPA (tetraisopropylpyrophosphoramide). Tetraisopropylpyrophosphamide 168-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 10704134-1 1999 Newly synthesized oximes, mono and bis imidazole derivatives, which promise to be more effective acetylcholinesterase reactivators than standard antidotes used, were investigated by spectrophotometric and electrochemical methods. Oximes 18-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 10704134-1 1999 Newly synthesized oximes, mono and bis imidazole derivatives, which promise to be more effective acetylcholinesterase reactivators than standard antidotes used, were investigated by spectrophotometric and electrochemical methods. mono and bis imidazole 26-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 10704134-3 1999 Dissociation constants of those oximes were also obtained by numerical treatment of overlapping equilibria, using the Lavendberg Marquardt least square method, and when compared with the same for some similar compounds, were found to be very effective acetylcholinesterase reactivators. Oximes 32-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 252-272 10704134-5 1999 The results indicated that many oxime anions will be available at physiological pH 7.4 and a relative increased ability to reactivate inhibited acetylcholinesterase could be expected. Oximes 32-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-164 10416605-5 1999 The glycinate esters are also 20-40-fold less potent than CPT-11 in inhibiting human acetylcholinesterase. glycinate esters 4-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 10416605-5 1999 The glycinate esters are also 20-40-fold less potent than CPT-11 in inhibiting human acetylcholinesterase. Irinotecan 58-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 10401781-1 1999 We measured brain acetylcholinesterase activity in 16 patients with Parkinson"s disease (PD), 12 patients with progressive supranuclear palsy (PSP), and 13 age-matched controls, using N-methyl-4-[11C]piperidyl acetate and positron emission tomography. n-methyl-4-[11c]piperidyl acetate 184-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 10362894-1 1999 Rivastigmine is a carbamate acetylcholinesterase (AChE) inhibitor with central selectivity. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 10445493-4 1999 Because of the reversibility of inhibition of acetylcholinesterase, the patients recovered after treatment with atropine and toxogonin. Atropine 112-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 10347238-1 1999 Torpedo acetylcholinesterase is irreversibly inactivated by modifying a buried free cysteine, Cys231, with sulfhydryl reagents. Cysteine 84-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-28 10365643-0 1999 Pharmacokinetics and pharmacodynamics of the acetylcholinesterase inhibitor metrifonate in patients with renal impairment. Trichlorfon 76-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 10365643-1 1999 The aim of this study was to assess the influence of renal function on the pharmacokinetics, pharmacodynamics, safety, and tolerability of the acetylcholinesterase inhibitor metrifonate. Trichlorfon 174-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 10346939-9 1999 In a similar manner, the same modifications that provided BChE selectivity were applied to the acetylcholinesterase (AChE)-selective inhibitor, tolserine (5), to provide the novel tolserine analogues 12-15. tolserine 144-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 10346939-9 1999 In a similar manner, the same modifications that provided BChE selectivity were applied to the acetylcholinesterase (AChE)-selective inhibitor, tolserine (5), to provide the novel tolserine analogues 12-15. tolserine 144-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 10346939-10 1999 As predicted, these modifications altered the AChE-selective action of tolserine (5) to favor a lack of cholinesterase enzyme subtype selectivity. tolserine 71-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 10421436-4 1999 AChE(H) generates GPI-anchored dimers, in Torpedo muscles and on mammalian blood cells. Glycosylphosphatidylinositols 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 10421436-8 1999 ColQ contains a short peptidic motif, the proline-rich attachment domain (PRAD), that triggers the formation of AChE(T) tetramers, from monomers and dimers. Proline 42-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 10421436-9 1999 The critical feature of this motif is the presence of a string of prolines, and in fact synthetic polyproline shows a similar capacity to organize AChE(T) tetramers. polyproline 98-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 10421439-4 1999 Volume calculations for the active-site gorge showed that the poor inhibitory activity of ethopropazine towards AChE was due to the smaller dimension of the active-site gorge. profenamine 90-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 10421439-5 1999 The volume of the BChE active-site gorge is approximately 200 A3 larger than that of the AChE gorge, which allows the accommodation of ethopropazine in two different orientations as demonstrated by rigid-body refinement and molecular dynamics calculations. profenamine 135-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 10421473-7 1999 Partially purified hemolymph AChE was inhibited by either 10 microM of echothiophate or 5 microM of paraoxon. Echothiophate 71-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 10421473-7 1999 Partially purified hemolymph AChE was inhibited by either 10 microM of echothiophate or 5 microM of paraoxon. Paraoxon 100-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 10421473-10 1999 In the presence of echothiophate-inhibited or praoxon-inhibited AChE, neurite growth was significantly reduced when compared to L15 + uninhibited AChE. Echothiophate 19-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 10421473-10 1999 In the presence of echothiophate-inhibited or praoxon-inhibited AChE, neurite growth was significantly reduced when compared to L15 + uninhibited AChE. praoxon 46-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 10421473-10 1999 In the presence of echothiophate-inhibited or praoxon-inhibited AChE, neurite growth was significantly reduced when compared to L15 + uninhibited AChE. praoxon 46-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 10210906-8 1999 Overall, these results show that: (1) [11C]MTHA crosses the blood-brain barrier easily and is highly concentrated in the brain; (2) the regional brain distribution of [11C]MTHA does not parallel that of in vivo acetylcholinesterase (AChE) concentrations; and (3) the cerebral kinetics of [11C]MTHA are consistent with known plasmatic pharmacokinetics of THA in AD patients. mtha 43-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-237 10363282-2 1999 A characteristic feature of these E-S products is the presence of a high level of acetylcholinesterase (AChE) activity, the biological significance of which remains unclear. H-GLU-SER-OH 34-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 10363282-2 1999 A characteristic feature of these E-S products is the presence of a high level of acetylcholinesterase (AChE) activity, the biological significance of which remains unclear. H-GLU-SER-OH 34-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 10378782-0 1999 Human erythrocyte acetylcholinesterase inhibition by cis-diamminediaquaplatinum (II): a novel kinetic approach. cis-diamminediaquaplatinum 53-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 10378782-3 1999 The authors recently reported that PDC and cisplatin have the ability to inhibit AChE activity in vitro. Cisplatin 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 10355543-2 1999 CPF-oxon (CPFO) inhibition curves of purified AChE (electric eel) were generated in the presence or absence of different concentrations of the PAHs pyrene, benzo(a)pyrene, anthracene, and fluoranthene. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 10355543-2 1999 CPF-oxon (CPFO) inhibition curves of purified AChE (electric eel) were generated in the presence or absence of different concentrations of the PAHs pyrene, benzo(a)pyrene, anthracene, and fluoranthene. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 10-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 10355543-3 1999 Without CPF-oxon, all four PAHs themselves inhibited AChE activity with IC50 values in the range 8.2-17 microM. Polycyclic Aromatic Hydrocarbons 27-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 10355543-4 1999 The IC50 for benzo(a)pyrene with human recombinant AChE was 1.5 microM. Benzo(a)pyrene 13-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 10355543-5 1999 When AChE was incubated with CPF-oxon together with the PAHs, the inhibitory effect on AChE was additive. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 29-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 10355543-5 1999 When AChE was incubated with CPF-oxon together with the PAHs, the inhibitory effect on AChE was additive. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 29-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 10355543-5 1999 When AChE was incubated with CPF-oxon together with the PAHs, the inhibitory effect on AChE was additive. Polycyclic Aromatic Hydrocarbons 56-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 10355543-5 1999 When AChE was incubated with CPF-oxon together with the PAHs, the inhibitory effect on AChE was additive. Polycyclic Aromatic Hydrocarbons 56-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 10355543-6 1999 This was exemplified by large (60-80%) and significant (P<0.01) inhibition in AChE activity by the PAHs when combined with nanomolar concentrations of CPF-oxon. Polycyclic Aromatic Hydrocarbons 102-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 10355543-6 1999 This was exemplified by large (60-80%) and significant (P<0.01) inhibition in AChE activity by the PAHs when combined with nanomolar concentrations of CPF-oxon. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 154-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 10355543-7 1999 Kinetic studies indicated that benzo(a)pyrene inhibited AChE in a noncompetitive manner, and the reduction in maximal velocity (Vmax) by benzo(a)pyrene and CPFO together was the sum of the inhibitory effect of the two inhibitors alone, further supporting an additive effect. Benzo(a)pyrene 31-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 10355543-7 1999 Kinetic studies indicated that benzo(a)pyrene inhibited AChE in a noncompetitive manner, and the reduction in maximal velocity (Vmax) by benzo(a)pyrene and CPFO together was the sum of the inhibitory effect of the two inhibitors alone, further supporting an additive effect. Benzo(a)pyrene 137-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 10355543-7 1999 Kinetic studies indicated that benzo(a)pyrene inhibited AChE in a noncompetitive manner, and the reduction in maximal velocity (Vmax) by benzo(a)pyrene and CPFO together was the sum of the inhibitory effect of the two inhibitors alone, further supporting an additive effect. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 156-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 10355543-8 1999 These data suggest that some PAHs have anticholinesterase activity, and contribute in an additive manner to the inhibitory effect of CPFO on AChE in vitro. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 133-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 10197614-0 1999 The anticancer prodrug CPT-11 is a potent inhibitor of acetylcholinesterase but is rapidly catalyzed to SN-38 by butyrylcholinesterase. Irinotecan 23-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 10197614-2 1999 Although CPT-11 was not a substrate for acetylcholinesterase (AcChE), in vitro assays confirmed that CPT-11 inhibited both human and electric eel AcChE with apparent K(i)s of 415 and 194 nM, respectively. Irinotecan 101-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-151 10197614-4 1999 Modeling of CPT-11 within the predicted active site of AcChE and BuChE corroborated experimental results indicating that, although the drug was oriented correctly for activation, the constraints dictated by the active site gorge were such that CPT-11 would be unlikely to be activated by AcChE. Irinotecan 12-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-60 10197614-4 1999 Modeling of CPT-11 within the predicted active site of AcChE and BuChE corroborated experimental results indicating that, although the drug was oriented correctly for activation, the constraints dictated by the active site gorge were such that CPT-11 would be unlikely to be activated by AcChE. Irinotecan 12-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 288-293 10197614-4 1999 Modeling of CPT-11 within the predicted active site of AcChE and BuChE corroborated experimental results indicating that, although the drug was oriented correctly for activation, the constraints dictated by the active site gorge were such that CPT-11 would be unlikely to be activated by AcChE. Irinotecan 244-250 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-60 10197614-4 1999 Modeling of CPT-11 within the predicted active site of AcChE and BuChE corroborated experimental results indicating that, although the drug was oriented correctly for activation, the constraints dictated by the active site gorge were such that CPT-11 would be unlikely to be activated by AcChE. Irinotecan 244-250 acetylcholinesterase (Cartwright blood group) Homo sapiens 288-293 10340441-3 1999 Considering that AChE only reacts with ACh as substrate and occurs with negligible activities in the serum, the measured individual activity ratio of BChE in the serum (Q(BChE)SE) and the total hydrolysis rate of ACh and BCh in the CSF do allow a precise calculation of the AChE activity in the cerebrospinal fluid. Acetylthiocholine 17-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 274-278 10340441-3 1999 Considering that AChE only reacts with ACh as substrate and occurs with negligible activities in the serum, the measured individual activity ratio of BChE in the serum (Q(BChE)SE) and the total hydrolysis rate of ACh and BCh in the CSF do allow a precise calculation of the AChE activity in the cerebrospinal fluid. Acetylthiocholine 39-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 10340441-3 1999 Considering that AChE only reacts with ACh as substrate and occurs with negligible activities in the serum, the measured individual activity ratio of BChE in the serum (Q(BChE)SE) and the total hydrolysis rate of ACh and BCh in the CSF do allow a precise calculation of the AChE activity in the cerebrospinal fluid. Butyrylthiocholine 150-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 10340441-5 1999 The inhibitor-free assay was compared with procedures using cholinesterase inhibitors (BW284c51 for AChE and/or iso-OMPA for BChE). Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide 87-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 10202874-1 1999 OBJECTIVE: To investigate the effect of pyridostigmine, an acetylcholinesterase inhibitor, as cotreatment for controlled ovarian hyperstimulation (COH) in low responders. Pyridostigmine Bromide 40-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 10332937-0 1999 Clinical benefits of a new piperidine-class AChE inhibitor. piperidine 27-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 10332937-4 1999 Donepezil HCI represents a new chemical class of AChE inhibitors, the piperidines. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 10332937-4 1999 Donepezil HCI represents a new chemical class of AChE inhibitors, the piperidines. Piperidines 70-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 10447153-6 1999 The results from three pivotal trials investigating the acetylcholinesterase inhibitor, donepezil, are used to demonstrate the way in which these tools are used, how to interpret the data they provide, and to determine their overall value in ascertaining efficacy in clinical practice. Donepezil 88-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 10230391-1 1999 This document presents a revised framework for conducting worker and dietary risk assessments for less-than-lifetime exposures to organophosphate or carbamate pesticides based on red blood cell (RBC) or brain acetylcholinesterase (AChE) inhibition or the presence of clinical signs and symptoms. Organophosphates 130-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 231-235 10230392-7 1999 It is concluded that all OP anticholinesterases potentially have a mechanism of toxicity in common, that is, phosphorylation of AChE causing accumulation of acetylcholine, overstimulation of cholinergic receptors, and consequent clinical signs of cholinergic toxicity. Acetylcholine 157-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 10395443-0 1999 Interaction of 3-alkylpyridinium polymers from the sea sponge Reniera sarai with insect acetylcholinesterase. 3-alkylpyridinium polymers 15-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 10395443-4 1999 To provide more information on mechanism of inhibition, interaction of poly-APS and N-butyl-3-butyl pyridinium iodide (NBPI) with soluble dimeric and monomeric insect acetylcholinesterase (AChE) was studied by using enzyme intrinsic fluorescence and light scattering, conformational probes ANS and trypsin, and SDS-PAGE. poly-APS 71-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-187 10395443-4 1999 To provide more information on mechanism of inhibition, interaction of poly-APS and N-butyl-3-butyl pyridinium iodide (NBPI) with soluble dimeric and monomeric insect acetylcholinesterase (AChE) was studied by using enzyme intrinsic fluorescence and light scattering, conformational probes ANS and trypsin, and SDS-PAGE. poly-APS 71-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-193 10395443-4 1999 To provide more information on mechanism of inhibition, interaction of poly-APS and N-butyl-3-butyl pyridinium iodide (NBPI) with soluble dimeric and monomeric insect acetylcholinesterase (AChE) was studied by using enzyme intrinsic fluorescence and light scattering, conformational probes ANS and trypsin, and SDS-PAGE. N-butyl-3-butylpyridinium 84-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-187 10549687-1 1999 BACKGROUND: Donepezil is an acetylcholinesterase inhibitor marketed for treatment of memory loss and behavioral deterioration associated with the acetylcholine deficit of Alzheimer"s disease. Donepezil 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 10363493-5 1999 RESULTS: Donepezil is a specific, reversible acetylcholinesterase inhibitor of close to 100% absorption and a half-life of 70 h, achieving stable concentrations at approximately 3 weeks. Donepezil 9-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 10363493-10 1999 Metriphonate is a prodrug of short life which inhibits acetylcholinesterase through a metabolite (DDVP) with a half-life in the circulation of 2 h. Improvement is observed in the ADAS-Cog scale and the CIBIC-Plus and in behavior disorders at doses of 0.3 and 0.65 mg/kg/day. Trichlorfon 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 10363493-12 1999 CONCLUSIONS: Different studies carried out with the acetylcholinesterase inhibitors donepezil, rivastigmine and metriphonate have been effective in the control of the cognitive symptoms of Alzheimer disease in the initial or moderate phases of the disease. Donepezil 84-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 10363493-12 1999 CONCLUSIONS: Different studies carried out with the acetylcholinesterase inhibitors donepezil, rivastigmine and metriphonate have been effective in the control of the cognitive symptoms of Alzheimer disease in the initial or moderate phases of the disease. Rivastigmine 95-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 10363493-12 1999 CONCLUSIONS: Different studies carried out with the acetylcholinesterase inhibitors donepezil, rivastigmine and metriphonate have been effective in the control of the cognitive symptoms of Alzheimer disease in the initial or moderate phases of the disease. Trichlorfon 112-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 10085081-4 1999 Kinetic rate constants were determined for the phosphorylation of AChE by two fluorogenic organophosphates, 7-[(diethoxyphosphoryl)oxy]-1-methylquinolinium iodide (DEPQ) and 7-[(methylethoxyphosphonyl)oxy]-4-methylcoumarin (EMPC), by monitoring release of the fluorescent leaving group. Organophosphates 90-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 10085081-4 1999 Kinetic rate constants were determined for the phosphorylation of AChE by two fluorogenic organophosphates, 7-[(diethoxyphosphoryl)oxy]-1-methylquinolinium iodide (DEPQ) and 7-[(methylethoxyphosphonyl)oxy]-4-methylcoumarin (EMPC), by monitoring release of the fluorescent leaving group. 7-[(diethoxyphosphoryl)oxy]-1-methylquinolinium iodide 108-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 10085081-4 1999 Kinetic rate constants were determined for the phosphorylation of AChE by two fluorogenic organophosphates, 7-[(diethoxyphosphoryl)oxy]-1-methylquinolinium iodide (DEPQ) and 7-[(methylethoxyphosphonyl)oxy]-4-methylcoumarin (EMPC), by monitoring release of the fluorescent leaving group. depq 164-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 10085081-4 1999 Kinetic rate constants were determined for the phosphorylation of AChE by two fluorogenic organophosphates, 7-[(diethoxyphosphoryl)oxy]-1-methylquinolinium iodide (DEPQ) and 7-[(methylethoxyphosphonyl)oxy]-4-methylcoumarin (EMPC), by monitoring release of the fluorescent leaving group. 7-[(methylethoxyphosphonyl)oxy]-4-methylcoumarin 174-222 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 10085081-4 1999 Kinetic rate constants were determined for the phosphorylation of AChE by two fluorogenic organophosphates, 7-[(diethoxyphosphoryl)oxy]-1-methylquinolinium iodide (DEPQ) and 7-[(methylethoxyphosphonyl)oxy]-4-methylcoumarin (EMPC), by monitoring release of the fluorescent leaving group. EMPC 224-228 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 10085081-7 1999 Binding of the small ligand propidium to the AChE peripheral site decreased kOP/KOP by factors of 2-20 for these organophosphates. Propidium 28-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 10085081-7 1999 Binding of the small ligand propidium to the AChE peripheral site decreased kOP/KOP by factors of 2-20 for these organophosphates. Organophosphates 113-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 10074358-0 1999 Exploring the active center of human acetylcholinesterase with stereomers of an organophosphorus inhibitor with two chiral centers. organophosphorus 80-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 10078712-4 1999 METHODS: Intravenous N-[11C]methylpiperidin-4-yl propionate ([11C]PMP) served as an in vivo AChE substrate. n-[11c]methylpiperidin-4-yl propionate 21-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 10078712-4 1999 METHODS: Intravenous N-[11C]methylpiperidin-4-yl propionate ([11C]PMP) served as an in vivo AChE substrate. UNII-S4X91EGA07 61-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 10078712-5 1999 AChE activity was defined using cerebral PET for tracer kinetic estimates of the local rate of [11C]PMP hydrolysis in 26 normal controls and 14 patients with AD. 11c]pmp 96-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 10078712-7 1999 RESULTS: Cerebral AChE activity measures 1) were independent of changes in tracer delivery to cerebral cortex; 2) agreed with reported postmortem data concerning normal relative cerebral distributions, absence of large age-effect in normal aging, and deficits in AD; 3) correlated in AD cerebral cortex with concomitant in vivo measures of cholinergic terminal deficits, but not with metabolic deficits; and 4) agreed quantitatively with predicted level of cerebral AChE inhibition induced by physostimine. physostimine 493-505 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 10207609-2 1999 Since the oxime effectiveness is influenced not only by its reactivating potential but also by inhibition, aging and spontaneous reactivation kinetics, experiments were performed with human acetyl- (AChE) and butyrylcholinesterase (BChE) to determine the respective kinetic constants. Oximes 10-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-203 10207609-3 1999 The efficacy of obidoxime in reactivating dimethylphosphoryl-AChE was 40, 9 and 3 times higher than of HI 6, pralidoxime and HLo 7, respectively. Obidoxime Chloride 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 10207609-3 1999 The efficacy of obidoxime in reactivating dimethylphosphoryl-AChE was 40, 9 and 3 times higher than of HI 6, pralidoxime and HLo 7, respectively. dimethylphosphoryl 42-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 10207609-5 1999 Calculation of steady-state AChE activity in the presence of inhibitor and oxime revealed that obidoxime was superior to pralidoxime. Obidoxime Chloride 95-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 10207609-5 1999 Calculation of steady-state AChE activity in the presence of inhibitor and oxime revealed that obidoxime was superior to pralidoxime. pralidoxime 121-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 10395443-4 1999 To provide more information on mechanism of inhibition, interaction of poly-APS and N-butyl-3-butyl pyridinium iodide (NBPI) with soluble dimeric and monomeric insect acetylcholinesterase (AChE) was studied by using enzyme intrinsic fluorescence and light scattering, conformational probes ANS and trypsin, and SDS-PAGE. N-butyl-3-butylpyridinium 84-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-193 10395443-4 1999 To provide more information on mechanism of inhibition, interaction of poly-APS and N-butyl-3-butyl pyridinium iodide (NBPI) with soluble dimeric and monomeric insect acetylcholinesterase (AChE) was studied by using enzyme intrinsic fluorescence and light scattering, conformational probes ANS and trypsin, and SDS-PAGE. N-butyl-3-butylpyridinium 119-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-187 10395443-4 1999 To provide more information on mechanism of inhibition, interaction of poly-APS and N-butyl-3-butyl pyridinium iodide (NBPI) with soluble dimeric and monomeric insect acetylcholinesterase (AChE) was studied by using enzyme intrinsic fluorescence and light scattering, conformational probes ANS and trypsin, and SDS-PAGE. N-butyl-3-butylpyridinium 119-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-193 10395443-5 1999 Poly-APS quenched tryptophan fluorescence emission of AChE more extensively than NBPI. poly-APS 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 10395443-5 1999 Poly-APS quenched tryptophan fluorescence emission of AChE more extensively than NBPI. Tryptophan 18-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 10395443-7 1999 Interaction of poly-APS with dimeric AChE did not induce significant changes of the enzyme conformation as assayed by using the hydrophobic probe ANS and trypsin digestion. poly-APS 15-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 10395443-8 1999 In contrast to NBPI, titration of both monomeric and dimeric AChE with poly-APS resulted in the appearance of large complexes detected by measuring light scattering. poly-APS 71-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 10395443-9 1999 An excess of poly-APS produced AChE precipitation as proved on SDS-PAGE. poly-APS 13-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 10395443-9 1999 An excess of poly-APS produced AChE precipitation as proved on SDS-PAGE. Sodium Dodecyl Sulfate 63-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 10395443-11 1999 It was concluded that AChE aggregation and precipitation rather than the enzyme conformational changes accounted for the observed irreversible component of poly-APS inhibition. poly-APS 156-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 10488245-0 1999 Inhibition of acetylcholinesterase by three new pyridinium compounds and their effect on phosphonylation of the enzyme. pyridine 48-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 10488245-1 1999 Three new mono-pyridinium compounds were prepared: 1-phenacyl-2-methylpyridinium chloride (1), 1-benzoylethylpyridinium chloride (2) and 1-benzoylethylpyridinium-4-aldoxime chloride (3) and assayed in vitro for their inhibitory effect on human blood acetylcholinesterase (EC 3.1.1.7, AChE). mono-pyridinium 10-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 250-270 10488245-1 1999 Three new mono-pyridinium compounds were prepared: 1-phenacyl-2-methylpyridinium chloride (1), 1-benzoylethylpyridinium chloride (2) and 1-benzoylethylpyridinium-4-aldoxime chloride (3) and assayed in vitro for their inhibitory effect on human blood acetylcholinesterase (EC 3.1.1.7, AChE). mono-pyridinium 10-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 284-288 10210264-2 1999 NXX-066, a physostigmine analog and acetylcholinesterase (AChE) inhibitor, has demonstrated activity in animal models of memory function, and was well tolerated in healthy subjects up to a single dose of 64 mg and multiple doses of 60 mg QD for seven days. quilostigmine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 10210264-2 1999 NXX-066, a physostigmine analog and acetylcholinesterase (AChE) inhibitor, has demonstrated activity in animal models of memory function, and was well tolerated in healthy subjects up to a single dose of 64 mg and multiple doses of 60 mg QD for seven days. quilostigmine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 10576601-1 1999 The force spectrum (FS) between acetylcholinesterase (AChE) molecule and its natural substrates acetylcholine (ACh) and the influences of AChE inhibitors and reactivators have been investigated with atomic force microscopy (AFM) at single molecule level in real-time. Acetylcholine 32-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 10576601-1 1999 The force spectrum (FS) between acetylcholinesterase (AChE) molecule and its natural substrates acetylcholine (ACh) and the influences of AChE inhibitors and reactivators have been investigated with atomic force microscopy (AFM) at single molecule level in real-time. Acetylcholine 54-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 10576601-2 1999 AChE and ACh were covalently immobilized onto the surfaces of gold-plated mica and Si3N4 tip of the atomic force microscope respectively. mica 74-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 10576601-2 1999 AChE and ACh were covalently immobilized onto the surfaces of gold-plated mica and Si3N4 tip of the atomic force microscope respectively. silicon nitride 83-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 9858601-1 1999 The extended human acetylcholinesterase (AChE) promoter contains many binding sites for osteogenic factors, including 1,25-(OH)2 vitamin D3 and 17beta-estradiol. Calcitriol 118-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 9858601-1 1999 The extended human acetylcholinesterase (AChE) promoter contains many binding sites for osteogenic factors, including 1,25-(OH)2 vitamin D3 and 17beta-estradiol. Calcitriol 118-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 9858601-1 1999 The extended human acetylcholinesterase (AChE) promoter contains many binding sites for osteogenic factors, including 1,25-(OH)2 vitamin D3 and 17beta-estradiol. Estradiol 144-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 9858601-1 1999 The extended human acetylcholinesterase (AChE) promoter contains many binding sites for osteogenic factors, including 1,25-(OH)2 vitamin D3 and 17beta-estradiol. Estradiol 144-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 9858601-3 1999 In contrast, antisense oligodeoxynucleotide suppression of E6-AChE mRNA expression increased Saos-2 proliferation in a dose- and sequence-dependent manner. Oligodeoxyribonucleotides 23-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 10096508-0 1999 Synthesis and evaluation of 6-[11C]methoxy-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-1,2- benzisoxazole as an in vivo radioligand for acetylcholinesterase. 6-[11c]methoxy-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-1,2- benzisoxazole 28-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 10096508-1 1999 6-Methoxy-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-1,2-benzisoxazole is a high affinity (K(i) = 8.2 nM) reversible inhibitor of acetylcholinesterase (AChE). 6-methoxy-3-(2-(1-(phenylmethyl)-4-piperidinyl)ethyl)-1,2-benzisoxazole 0-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-151 10096508-1 1999 6-Methoxy-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-1,2-benzisoxazole is a high affinity (K(i) = 8.2 nM) reversible inhibitor of acetylcholinesterase (AChE). 6-methoxy-3-(2-(1-(phenylmethyl)-4-piperidinyl)ethyl)-1,2-benzisoxazole 0-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 10218828-2 1999 To provide a further test of the dual binding site hypothesis proposed for acetylcholinesterase (AChE) inhibitor heptylene-linked bis-(9-amino-1,2,3,4-tetrahydroacridine) A7A, short-tether (ethylene hexylene) homologs A2A-A6A were prepared. 1-HEPTENE 113-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 10218828-2 1999 To provide a further test of the dual binding site hypothesis proposed for acetylcholinesterase (AChE) inhibitor heptylene-linked bis-(9-amino-1,2,3,4-tetrahydroacridine) A7A, short-tether (ethylene hexylene) homologs A2A-A6A were prepared. 1-HEPTENE 113-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 10218828-2 1999 To provide a further test of the dual binding site hypothesis proposed for acetylcholinesterase (AChE) inhibitor heptylene-linked bis-(9-amino-1,2,3,4-tetrahydroacridine) A7A, short-tether (ethylene hexylene) homologs A2A-A6A were prepared. linked bis-(9-amino-1,2,3,4-tetrahydroacridine) a7a 123-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 10218828-5 1999 Finally, these studies indicate that simultaneous binding of alkylene-linked 9-amino-1,2,3,4-tetrahydroacridine dimers to the catalytic and peripheral sites of AChE is possible with a tether length as short as 5 methylenes. alkylene 61-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 10218828-5 1999 Finally, these studies indicate that simultaneous binding of alkylene-linked 9-amino-1,2,3,4-tetrahydroacridine dimers to the catalytic and peripheral sites of AChE is possible with a tether length as short as 5 methylenes. Tacrine 77-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 9933347-1 1999 The regional cerebral metabolic rate of [11C]N-methyl-4-piperidyl acetate, which is nearly proportional to regional cerebral acetylcholinesterase (AChE) activity, was measured by dynamic positron emission tomography in 20 healthy subjects with a wide age range (24-89 years). 11c]n-methyl-4-piperidyl acetate 41-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 9933347-1 1999 The regional cerebral metabolic rate of [11C]N-methyl-4-piperidyl acetate, which is nearly proportional to regional cerebral acetylcholinesterase (AChE) activity, was measured by dynamic positron emission tomography in 20 healthy subjects with a wide age range (24-89 years). 11c]n-methyl-4-piperidyl acetate 41-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 10229710-1 1999 Acetylcholinesterase (AChE) is the enzyme that hydrolyzes the neurotransmitter acetylcholine at cholinergic synapses and neuromuscular junctions. Acetylcholine 79-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 10229710-1 1999 Acetylcholinesterase (AChE) is the enzyme that hydrolyzes the neurotransmitter acetylcholine at cholinergic synapses and neuromuscular junctions. Acetylcholine 79-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 10229710-5 1999 These results could have additional significance as AChE is the target enzyme of agricultural organophosphate and carbamate pesticides as well as the commonly used household organophosphate chlorpyrifos (Dursban). Organophosphates 94-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 10229710-5 1999 These results could have additional significance as AChE is the target enzyme of agricultural organophosphate and carbamate pesticides as well as the commonly used household organophosphate chlorpyrifos (Dursban). Carbamates 114-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 10229710-5 1999 These results could have additional significance as AChE is the target enzyme of agricultural organophosphate and carbamate pesticides as well as the commonly used household organophosphate chlorpyrifos (Dursban). Organophosphates 174-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 10229710-5 1999 These results could have additional significance as AChE is the target enzyme of agricultural organophosphate and carbamate pesticides as well as the commonly used household organophosphate chlorpyrifos (Dursban). Chlorpyrifos 190-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 10229710-5 1999 These results could have additional significance as AChE is the target enzyme of agricultural organophosphate and carbamate pesticides as well as the commonly used household organophosphate chlorpyrifos (Dursban). Chlorpyrifos 204-211 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 9918593-1 1999 Our previous studies demonstrated that huperzine A, a reversible and selective acetylcholinesterase inhibitor, exerts beneficial effects on memory deficits in various rodent models of amnesia. huperzine A 39-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 10333298-6 1999 The simultaneous presence of Fas-D and Fas-B produced an additive inhibitory effect on AChE activity; calculated Ki and alphaKi values (7.3 +/-2.4 microM and 10.0 +/- 1.8 microM, respectively) were not significantly different, thus indicating noncompetitive inhibition. Deuterium 33-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 10333298-6 1999 The simultaneous presence of Fas-D and Fas-B produced an additive inhibitory effect on AChE activity; calculated Ki and alphaKi values (7.3 +/-2.4 microM and 10.0 +/- 1.8 microM, respectively) were not significantly different, thus indicating noncompetitive inhibition. Fas-B 39-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 10051415-0 1999 Human red blood cell acetylcholinesterase inhibition as the appropriate and conservative surrogate endpoint for establishing chlorpyrifos reference dose. Chlorpyrifos 125-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 10051415-4 1999 Basing an acceptable level of human exposure (e.g., RfD) on inhibition of RBC AChE provides a significant margin of safety, since it is 12- to 14-fold more sensitive as an indicator of chlorpyrifos exposure than the AChE in the most sensitive relevant neurological tissues (brain or retina). Chlorpyrifos 185-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 10051415-5 1999 Inhibition of RBC AChE activity is consistently exhibited at lower dosages of chlorpyrifos than those required to result in clinical symptoms of OP toxicity, or alterations in cognitive functional responses. Chlorpyrifos 78-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 10051415-7 1999 Thus, inhibition of RBC AChE activity is an appropriate surrogate measurement of chlorpyrifos exposure and provides a conservative endpoint for establishing appropriate margins of safety for both adults and infants. Chlorpyrifos 81-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 10067428-7 1999 We replaced the N-benzylpiperazine moiety with N-benzylpiperidine moiety and found a dramatic increase in anti-AChE activity. N-benzylpiperazine 16-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 10067428-7 1999 We replaced the N-benzylpiperazine moiety with N-benzylpiperidine moiety and found a dramatic increase in anti-AChE activity. 1-benzylpiperidine 47-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 9930975-9 1999 The inactivation of acetylcholinesterase with the same series of organophosphate nerve agents was also measured. Organophosphates 65-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 9890890-6 1999 Previous reaction schemes for substrate hydrolysis by AChE were extended to include product dissociation steps, and acetylthiocholine hydrolysis rates in the presence of propidium under nonequilibrium conditions were simulated with assigned rate constants in the program SCoP. Acetylthiocholine 116-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 9890890-6 1999 Previous reaction schemes for substrate hydrolysis by AChE were extended to include product dissociation steps, and acetylthiocholine hydrolysis rates in the presence of propidium under nonequilibrium conditions were simulated with assigned rate constants in the program SCoP. Propidium 170-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 9890890-13 1999 However, our analyses indicate that the primary physiologic role of the AChE peripheral site is to accelerate the hydrolysis of acetylcholine at low substrate concentrations. Acetylcholine 128-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 10192638-1 1999 The purpose of the present study was to evaluate methanesulfonyl fluoride (MSF), a very long-acting CNS-selective acetylcholinesterase (AChE) inhibitor, as a palliative treatment for senile dementia of the Alzheimer type (SDAT). methanesulfonyl fluoride 49-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 10192638-1 1999 The purpose of the present study was to evaluate methanesulfonyl fluoride (MSF), a very long-acting CNS-selective acetylcholinesterase (AChE) inhibitor, as a palliative treatment for senile dementia of the Alzheimer type (SDAT). methanesulfonyl fluoride 75-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 23902387-3 1999 AChE activity is highly sensitive to organophosphorus and carbamate insecticides but also to heavy metals. organophosphorus 37-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 23902387-3 1999 AChE activity is highly sensitive to organophosphorus and carbamate insecticides but also to heavy metals. Carbamates 58-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 10396392-5 1999 METHOD: RBC AChE activity was determined ex vivo by Kaplan"s spectrophotometric method in 19 POAG patients undergoing topical treatment for glaucoma with timolol, pilocarpine or a combination of the two drugs, and compared with that in 20 controls. Timolol 154-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-16 10396392-5 1999 METHOD: RBC AChE activity was determined ex vivo by Kaplan"s spectrophotometric method in 19 POAG patients undergoing topical treatment for glaucoma with timolol, pilocarpine or a combination of the two drugs, and compared with that in 20 controls. Pilocarpine 163-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-16 10396392-8 1999 However, timolol and pilocarpine, individually or in combination, have the opposite effect, significantly decreasing RBC AChE activity (p < 0.05). Timolol 9-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 10396392-8 1999 However, timolol and pilocarpine, individually or in combination, have the opposite effect, significantly decreasing RBC AChE activity (p < 0.05). Pilocarpine 21-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 9876215-4 1999 Donepezil HCl, for example, is a piperidine-based, reversible acetylcholinesterase (AChE) inhibitor, chemically distinct from other ChE inhibitors and rationally designed for the symptomatic treatment of AD. Donepezil 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 9876215-4 1999 Donepezil HCl, for example, is a piperidine-based, reversible acetylcholinesterase (AChE) inhibitor, chemically distinct from other ChE inhibitors and rationally designed for the symptomatic treatment of AD. Donepezil 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 9876215-4 1999 Donepezil HCl, for example, is a piperidine-based, reversible acetylcholinesterase (AChE) inhibitor, chemically distinct from other ChE inhibitors and rationally designed for the symptomatic treatment of AD. piperidine 33-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 9876215-4 1999 Donepezil HCl, for example, is a piperidine-based, reversible acetylcholinesterase (AChE) inhibitor, chemically distinct from other ChE inhibitors and rationally designed for the symptomatic treatment of AD. piperidine 33-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 10207609-7 1999 These data indicate that oximes may effectively reactivate human dimethylphosphoryl-AChE. Oximes 25-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 10207609-7 1999 These data indicate that oximes may effectively reactivate human dimethylphosphoryl-AChE. dimethylphosphoryl 65-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 10377794-1 1999 Recently, we have developed a method to measure acetylcholinesterase (AChE) activity, a functional marker for cholinergic system, by positron emission tomography (PET) and carbon-11 labeled N-methyl-4-piperidyl acetate. Carbon-11 172-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 10377794-1 1999 Recently, we have developed a method to measure acetylcholinesterase (AChE) activity, a functional marker for cholinergic system, by positron emission tomography (PET) and carbon-11 labeled N-methyl-4-piperidyl acetate. Carbon-11 172-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 10377794-1 1999 Recently, we have developed a method to measure acetylcholinesterase (AChE) activity, a functional marker for cholinergic system, by positron emission tomography (PET) and carbon-11 labeled N-methyl-4-piperidyl acetate. N-methyl-4-piperidyl acetate 190-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 10377794-1 1999 Recently, we have developed a method to measure acetylcholinesterase (AChE) activity, a functional marker for cholinergic system, by positron emission tomography (PET) and carbon-11 labeled N-methyl-4-piperidyl acetate. N-methyl-4-piperidyl acetate 190-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 10022255-5 1998 The species specificity of this phenomenon was clearly displayed in Xenopus tadpoles expressing recombinant human AChE, which was far more sensitive than the frog enzyme to in vivo paraoxon inhibition. Paraoxon 181-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 10022304-2 1998 Their acute toxic effect in the central and peripheral nervous system is due to inhibition of acetylcholinesterase (AChE) at nerve endings which causes accumulation of acetylcholine and consequently overstimulation of the nicotinic and muscarinic receptors. Acetylcholine 94-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 10022329-3 1998 Phosphates (P=O) are biologically active as AChE inhibitors, whereas phosphorothioates (P=S) need bioactivation to their phosphate anologues (oxons) to become biologically active. Phosphates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 10022329-4 1998 Oxons inhibit AChE by phosphorylation of the serine hydroxyl group in the substrate-binding domain of the enzyme. serine hydroxyl 45-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 9841877-1 1998 Sialylation of N-glycans associated with recombinant human acetylcholinesterase (rHuAChE) has a central role in determining its circulatory clearance rate. n-glycans 15-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 9988368-11 1998 Unexpectedly, paraoxon levels occasionally reincreased during treatment and resulted in re-inhibition of AChE, bearing some resemblance to the Intermediate Syndrome. Paraoxon 14-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 18967406-7 1998 The limit of detection for the determination of acetylcholine was found to be 8x10(-5) M. The method described could be advantageously used for indirect determination of acetylcholinesterase inhibitors. Acetylcholine 48-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-190 9924498-6 1999 Augmentation of cholinergic function through the use of acetylcholinesterase inhibitors with favorable side-effect profiles (e.g., donepezil, possibly metrifonate) can create the potential for improved memory and cognition. Donepezil 131-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 9924498-6 1999 Augmentation of cholinergic function through the use of acetylcholinesterase inhibitors with favorable side-effect profiles (e.g., donepezil, possibly metrifonate) can create the potential for improved memory and cognition. Trichlorfon 151-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 10049178-0 1998 Effects of halothane and supporting membrane lipids on the activity of acetylcholinesterase. Halothane 11-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 10049178-2 1998 The activity of acetylcholinesterase in the human erythrocyte membrane was measured with and without halothane. Halothane 101-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 9799227-1 1998 The major type of acetylcholinesterase in vertebrates (AChET) is characterized by the presence of a short C-terminal domain of 40 residues, the "tryptophan amphiphilic tetramerization" (WAT) domain. Tryptophan 145-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 9839758-1 1998 AIM: The aim of this study was to characterize the pharmacokinetic and pharmacodynamic profile of donepezil HCl, a chemically distinct and specific acetylcholinesterase (AChE) inhibitor for the treatment of Alzheimer"s disease, following administration of single oral doses. Donepezil 98-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-168 9839758-1 1998 AIM: The aim of this study was to characterize the pharmacokinetic and pharmacodynamic profile of donepezil HCl, a chemically distinct and specific acetylcholinesterase (AChE) inhibitor for the treatment of Alzheimer"s disease, following administration of single oral doses. Donepezil 98-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 9839758-8 1998 A direct correlation was observed between plasma donepezil concentrations and extent of AChE inhibition. Donepezil 49-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 9839758-9 1998 For the 4.0 and 6.0 mg donepezil dose groups, maximal AChE inhibition (Emax) ranged from 33% to 35% and there was significant correlation between AChE inhibition and donepezil plasma concentration (P<0.005). Donepezil 23-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 9839758-9 1998 For the 4.0 and 6.0 mg donepezil dose groups, maximal AChE inhibition (Emax) ranged from 33% to 35% and there was significant correlation between AChE inhibition and donepezil plasma concentration (P<0.005). Donepezil 23-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 9839758-11 1998 A direct correlation was also observed between plasma donepezil concentrations and AChE inhibition. Donepezil 54-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 9839759-1 1998 AIM: The aim of this study was to characterize the pharmacokinetics and pharmacodynamics of donepezil HCl, a new, chemically distinct and specific acetylcholinesterase (AChE) inhibitor for the treatment of Alzheimer"s disease, following multiple-dose administration. Donepezil 92-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 9839759-1 1998 AIM: The aim of this study was to characterize the pharmacokinetics and pharmacodynamics of donepezil HCl, a new, chemically distinct and specific acetylcholinesterase (AChE) inhibitor for the treatment of Alzheimer"s disease, following multiple-dose administration. Donepezil 92-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 9839759-11 1998 Inhibition of rbc-AChE was directly correlated with donepezil concentration over a wide concentration range, with the higher concentrations showing the expected hyperbolic relationship. Donepezil 52-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 9839759-14 1998 A predictable relationship was also observed between plasma donepezil concentrations and rbc-AChE inhibition. Donepezil 60-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 9923589-0 1998 Acetylcholinesterase assay may predict cognitive response of Alzheimer patients to eptastigmine treatment. physostigmine heptyl 83-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 9863562-0 1998 Synthesis of 1-[11C]methylpiperidin-4-yl propionate ([11C]PMP) for in vivo measurements of acetylcholinesterase activity. UNII-S4X91EGA07 13-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 9863562-0 1998 Synthesis of 1-[11C]methylpiperidin-4-yl propionate ([11C]PMP) for in vivo measurements of acetylcholinesterase activity. UNII-S4X91EGA07 53-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 9863562-1 1998 Synthesis of 1-[11C]methylpiperidin-4-yl propionate ([11C]PMP), an in vivo substrate for acetylcholinesterase, is reported. UNII-S4X91EGA07 13-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 9863562-1 1998 Synthesis of 1-[11C]methylpiperidin-4-yl propionate ([11C]PMP), an in vivo substrate for acetylcholinesterase, is reported. UNII-S4X91EGA07 53-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 9863562-6 1998 [11C]PMP can thus be reliably prepared for routine clinical studies of acetylcholinesterase in human brain using positron emission tomography. Carbon-11 1-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 9863563-0 1998 N-[11C]methylpiperidine esters as acetylcholinesterase substrates: an in vivo structure-reactivity study. n-[11c]methylpiperidine esters 0-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 9863563-4 1998 Methylation of 4-N-[11C]methylpiperidinyl propionate at the 3-position gives a derivative with increased in vivo reactivity toward acetylcholinesterase. 4-n-[11c]methylpiperidinyl propionate 15-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-151 9863563-6 1998 This study has identified simple methods to both increase and decrease the in vivo reactivity of piperidinyl esters toward acetylcholinesterase. piperidinyl esters 97-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-143 9863564-0 1998 Syntheses of carbon-11 labeled piperidine esters as potential in vivo substrates for acetylcholinesterase. Carbon-11 13-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 9863564-0 1998 Syntheses of carbon-11 labeled piperidine esters as potential in vivo substrates for acetylcholinesterase. piperidine esters 31-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 9863564-1 1998 A series of carbon-11 labeled N-methylpiperidinyl esters were prepared as potential in vivo substrates for acetylcholinesterase (AChE). Carbon-11 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 9863564-1 1998 A series of carbon-11 labeled N-methylpiperidinyl esters were prepared as potential in vivo substrates for acetylcholinesterase (AChE). Carbon-11 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 9863564-1 1998 A series of carbon-11 labeled N-methylpiperidinyl esters were prepared as potential in vivo substrates for acetylcholinesterase (AChE). n-methylpiperidinyl esters 30-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 9863564-1 1998 A series of carbon-11 labeled N-methylpiperidinyl esters were prepared as potential in vivo substrates for acetylcholinesterase (AChE). n-methylpiperidinyl esters 30-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 9790671-5 1998 These pKs are consistent with the involvement of two carboxylic acids, possibly E202(199) and either E334(327) or E450(443), and H447(440)H+ in the dealkylation of AChE. Carboxylic Acids 53-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 9742217-4 1998 Studies with HuAChE mutants carrying replacements at positions 86, 133 and 337 indicate that the orientations of huperzine A and tacrine in the HuAChE complexes in solution are significantly different from those observed in X-ray structures of the corresponding complexes with Torpedo californica AChE (TcAChE). Tacrine 129-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 9839013-0 1998 Potent acetylcholinesterase inhibitors: design, synthesis, and structure-activity relationships of bis-interacting ligands in the galanthamine series. Galantamine 130-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 7-27 9839013-1 1998 New galanthamine derivatives, especially bis-interacting ligands 3-5 and 7-9 were prepared in order to interact with the catalytic and the peripheral sites of acetylcholinesterase (AChE). Galantamine 4-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 9839013-1 1998 New galanthamine derivatives, especially bis-interacting ligands 3-5 and 7-9 were prepared in order to interact with the catalytic and the peripheral sites of acetylcholinesterase (AChE). Galantamine 4-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 9839013-3 1998 Compounds 4d-e were found to be more potent than galanthamine and tacrine in inhibiting AChE. Galantamine 49-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 9839013-3 1998 Compounds 4d-e were found to be more potent than galanthamine and tacrine in inhibiting AChE. Tacrine 66-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 9988368-13 1998 The paraoxon concentrations measured fitted satisfactorily the values calculated from the kinetic constants previously obtained for AChE inhibition and obidoxime-induced reactivation in vitro. Paraoxon 4-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 9729629-11 1998 Acetylcholinesterase (AChE) may not be involved in SP degradation since Ca2+ responses evoked by SP were unchanged in the presence of the cholinesterase inhibitor neostigmine. Neostigmine 163-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 9789840-13 1998 AChE reactivation was only observed in the PA group, although it was not statistically significant (r = 0.4747). Protactinium 43-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 9794506-1 1998 PURPOSE: SDZ ENA 713 (rivastigmine) is an acetylcholinesterase inhibitor intended for therapeutic use in Alzheimer"s disease. Rivastigmine 22-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 9753626-6 1998 Lastly, we established that this proteoglycan, but not the collagenous proteins, interacted with at least one heparin binding domain of the collagenic tail of AChE. Heparin 110-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 9748587-0 1998 Inhibition of acetylcholinesterase by an alkylpyridinium polymer from the marine sponge, Reniera sarai. alkylpyridinium polymer 41-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 9748587-5 1998 The polymers also act as acetylcholinesterase inhibitors and show an unusual inhibition pattern. Polymers 4-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 9806430-2 1998 To give more insight into the inhibition, reactivation and aging kinetics, human acetyl-(AChE) and butyrylcholinesterase (BChE) were inhibited by cyclosarin (k2 of 7.4 and 3.8 x 10(8) M(-1) min(-1), respectively; pH 7.4, 37 degrees C) and reactivated with obidoxime, pralidoxime and three experimental oximes. cyclohexyl methylphosphonofluoridate 146-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 9806430-4 1998 At oxime concentrations anticipated to be relevant in humans, obidoxime and pralidoxime were extremely weak reactivators of AChE. Obidoxime Chloride 62-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 9806430-4 1998 At oxime concentrations anticipated to be relevant in humans, obidoxime and pralidoxime were extremely weak reactivators of AChE. pralidoxime 76-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 9792201-2 1998 It is suggested that research on genotype/phenotype of acetylcholinesterase and butyrylcholinesterase may help to discover the role of pyridostigmine bromide in the cause of Gulf War Syndrome. Pyridostigmine Bromide 135-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 9758325-1 1998 Seizures occurred in two patients with probable Alzheimer"s disease who were receiving long-term treatment with metrifonate, an irreversible acetylcholinesterase inhibitor. Trichlorfon 112-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 9737824-0 1998 Clinical pharmacology of rivastigmine: a new-generation acetylcholinesterase inhibitor for the treatment of Alzheimer"s disease. Rivastigmine 25-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 9737824-1 1998 Rivastigmine (ENA 713, or carbamoylatine) is an acetylcholinesterase (AChE) inhibitor with brain-region selectivity and a long duration of action. carbamoylatine 26-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 9737824-1 1998 Rivastigmine (ENA 713, or carbamoylatine) is an acetylcholinesterase (AChE) inhibitor with brain-region selectivity and a long duration of action. carbamoylatine 26-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 9737824-2 1998 Both preclinical studies and studies in human volunteers have shown that rivastigmine induces substantially greater inhibition of AChE in the central nervous system (CNS) compartment than in the periphery (40% inhibition of central AChE compared with 10% inhibition of plasma butylcholinesterase in healthy volunteers). Rivastigmine 73-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 9737824-2 1998 Both preclinical studies and studies in human volunteers have shown that rivastigmine induces substantially greater inhibition of AChE in the central nervous system (CNS) compartment than in the periphery (40% inhibition of central AChE compared with 10% inhibition of plasma butylcholinesterase in healthy volunteers). Rivastigmine 73-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 232-236 9737824-3 1998 Moreover, rivastigmine preferentially inhibits the G1 enzymatic form of AChE, which predominates in the brains of patients with Alzheimer"s disease (AD). Rivastigmine 10-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 9737824-4 1998 Evidence from animal studies also suggests that rivastigmine is a more potent inhibitor of AChE in the cortex and hippocampus, the brain regions most affected by AD. Rivastigmine 48-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 9737824-7 1998 The principal metabolite of rivastigmine has at least 10-fold lower activity against AChE compared with the parent drug. Rivastigmine 28-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 9737824-10 1998 Distribution of rivastigmine into the CNS is extensive, and inhibition of AChE in the cerebrospinal fluid is detectable 1.2 hours after oral dosing in both healthy volunteers and patients with AD. Rivastigmine 16-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 9737824-12 1998 Rivastigmine is inactivated during the process of interacting with and inhibiting AChE, and, in contrast to other AChE inhibitors, the hepatic cytochrome P-450 (CYP-450) system is not involved in the metabolism of rivastigmine. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 9742217-1 1998 The role of the functional architecture of the human acetylcholinesterase (HuAChE) active centre in accommodating the non-covalent inhibitors tacrine and huperzine A, or the carbamates pyridostigmine and physostigmine, was analysed using 16 mutants of residues lining the active-centre gorge. Tacrine 142-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 9742217-1 1998 The role of the functional architecture of the human acetylcholinesterase (HuAChE) active centre in accommodating the non-covalent inhibitors tacrine and huperzine A, or the carbamates pyridostigmine and physostigmine, was analysed using 16 mutants of residues lining the active-centre gorge. huperzine A 154-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 9742217-1 1998 The role of the functional architecture of the human acetylcholinesterase (HuAChE) active centre in accommodating the non-covalent inhibitors tacrine and huperzine A, or the carbamates pyridostigmine and physostigmine, was analysed using 16 mutants of residues lining the active-centre gorge. carbamates pyridostigmine 174-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 9742217-1 1998 The role of the functional architecture of the human acetylcholinesterase (HuAChE) active centre in accommodating the non-covalent inhibitors tacrine and huperzine A, or the carbamates pyridostigmine and physostigmine, was analysed using 16 mutants of residues lining the active-centre gorge. Physostigmine 204-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 9742217-4 1998 Studies with HuAChE mutants carrying replacements at positions 86, 133 and 337 indicate that the orientations of huperzine A and tacrine in the HuAChE complexes in solution are significantly different from those observed in X-ray structures of the corresponding complexes with Torpedo californica AChE (TcAChE). huperzine A 113-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 9744565-4 1998 We have examined the kinetics of inhibition of AChE and butyrylcholinesterase (BChE) by paraoxon and CPO. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 101-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 9744565-0 1998 Inhibition of acetylcholinesterase and butyrylcholinesterase by chlorpyrifos-oxon. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 64-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 9744565-2 1998 The insecticidal action of chlorpyrifos stems from inhibition of acetylcholinesterase (AChE) by CPO, resulting in severe cholinergic toxicity. Chlorpyrifos 27-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 9744565-2 1998 The insecticidal action of chlorpyrifos stems from inhibition of acetylcholinesterase (AChE) by CPO, resulting in severe cholinergic toxicity. Chlorpyrifos 27-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 9744565-2 1998 The insecticidal action of chlorpyrifos stems from inhibition of acetylcholinesterase (AChE) by CPO, resulting in severe cholinergic toxicity. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 96-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 9744565-2 1998 The insecticidal action of chlorpyrifos stems from inhibition of acetylcholinesterase (AChE) by CPO, resulting in severe cholinergic toxicity. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 96-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 9744565-5 1998 The bimolecular rate constants (ki) for inhibition by paraoxon of recombinant human (rH) AChE, recombinant mouse (rM) AChE, and fetal bovine serum (FBS) AChE were 7.0, 4.0, and 3.2 x 10(5) M(-1) min(-1). Paraoxon 54-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 9744565-6 1998 The ki values for the inhibition by CPO of rH AChE, fetal bovine serum AChE, human RBC AChE, Torpedo AChE, and recombinant mouse (rM) AChE were 9.3, 2.2, 3.8, 8.0, and 5.1 x 10(6) M(-1) min(-1), respectively. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 36-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 9744565-10 1998 The double mutant of acyl pocket residues of rH AChE, F295L/F297V, was inhibited by CPO with a 150-fold larger ki than wild type (1.5 x 10(9) vs 1.0 x 10(7) M(-1) min(-1)). O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 84-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 9758554-1 1998 Pseudo-irreversible AChE inhibition with rivastigmine]. Rivastigmine 41-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 9758555-1 1998 Irreversible AChE inhibition with metrifonate]. Trichlorfon 34-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 9745921-0 1998 Comparative studies of O,O-dialkyl-O-chloromethylchloroformimino phosphates: interaction with neuropathy target esterase and acetylcholinesterase. o,o-dialkyl-o-chloromethylchloroformimino phosphates 23-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 9745921-1 1998 Acetylcholinesterase (AChE) and neuropathy target esterase (neurotoxic esterase, NTE) are two major target enzymes for organophosphorus (OP) esters. organophosphorus (op) esters 119-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 9745921-1 1998 Acetylcholinesterase (AChE) and neuropathy target esterase (neurotoxic esterase, NTE) are two major target enzymes for organophosphorus (OP) esters. organophosphorus (op) esters 119-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 9745921-2 1998 The relative potency of an OP ester to react with AChE or with NTE in vitro correlates with its relative potency in vivo to cause acute toxicity (death) or organopohosphate-induced delayed neurotoxicity (OPIDN). op ester 27-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 9745921-4 1998 The kinetics of NTE and AChE inhibition by experimental pesticides of the general formula (RO)2P(O)ON=CClCH2Cl, where R = methyl, ethyl, isopropyl, propyl, isobutyl, butyl, pentyl, has been studied. cclch2cl 102-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 9726096-3 1998 A cholinergic syndrome resulting from the inhibition of acetylcholinesterase activity by irinotecan is frequently seen within the first 24 hours after irinotecan administration but is easily controlled with atropine. Irinotecan 89-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 9726096-3 1998 A cholinergic syndrome resulting from the inhibition of acetylcholinesterase activity by irinotecan is frequently seen within the first 24 hours after irinotecan administration but is easily controlled with atropine. Irinotecan 151-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 9726096-3 1998 A cholinergic syndrome resulting from the inhibition of acetylcholinesterase activity by irinotecan is frequently seen within the first 24 hours after irinotecan administration but is easily controlled with atropine. Atropine 207-215 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 9677373-1 1998 The contribution of the oxyanion hole to the functional architecture and to the hydrolytic efficiency of human acetylcholinesterase (HuAChE) was investigated through single replacements of its elements, residues Gly-121, Gly-122 and the adjacent residue Gly-120, by alanine. Glycine 212-215 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 9677373-1 1998 The contribution of the oxyanion hole to the functional architecture and to the hydrolytic efficiency of human acetylcholinesterase (HuAChE) was investigated through single replacements of its elements, residues Gly-121, Gly-122 and the adjacent residue Gly-120, by alanine. Glycine 221-224 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 9675107-0 1998 Kinetics of human erythrocyte acetylcholinesterase inhibition by a novel derivative of physostigmine: phenserine. Physostigmine 87-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 9675107-0 1998 Kinetics of human erythrocyte acetylcholinesterase inhibition by a novel derivative of physostigmine: phenserine. phenserine 102-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 9675107-1 1998 The effect of phenserine, a novel cholinesterase inhibitor, was assessed for the first time on kinetic parameters of human erythrocyte acetylcholinesterase (AChE). phenserine 14-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 9675107-1 1998 The effect of phenserine, a novel cholinesterase inhibitor, was assessed for the first time on kinetic parameters of human erythrocyte acetylcholinesterase (AChE). phenserine 14-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 9675107-2 1998 Phenserine (0.025-0.40 microM) inhibited the activity of human erythrocyte AChE in a concentration-dependent fashion, the IC50 was 0.0453 microM. phenserine 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 9873409-0 1998 Synthesis and acetylcholinesterase inhibitory activity of (+/-)-14-fluorohuperzine A. 14-fluorohuperzine A 58-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 9873409-1 1998 The synthesis of (+/-)-14-Fluorohuperzine A has been accomplished and the ability of this agent to inhibit acetylcholinesterase has been measured. 14-fluorohuperzine A 17-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 9737824-1 1998 Rivastigmine (ENA 713, or carbamoylatine) is an acetylcholinesterase (AChE) inhibitor with brain-region selectivity and a long duration of action. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 9737824-1 1998 Rivastigmine (ENA 713, or carbamoylatine) is an acetylcholinesterase (AChE) inhibitor with brain-region selectivity and a long duration of action. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 9737824-1 1998 Rivastigmine (ENA 713, or carbamoylatine) is an acetylcholinesterase (AChE) inhibitor with brain-region selectivity and a long duration of action. Rivastigmine 14-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 9737824-1 1998 Rivastigmine (ENA 713, or carbamoylatine) is an acetylcholinesterase (AChE) inhibitor with brain-region selectivity and a long duration of action. Rivastigmine 14-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 9789819-8 1998 The results suggest a feedback mechanism by which the AChE gene is activated by cholinergic neurotransmission, possibly leading to increased formation of AChE protein and accelerated degradation of acetylcholine at cholinergic synapses. Acetylcholine 198-211 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 9702845-1 1998 Eptastigmine is a new acetylcholinesterase (AChE) inhibitor currently under development for the symptomatic treatment of Alzheimer disease. physostigmine heptyl 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 9702845-1 1998 Eptastigmine is a new acetylcholinesterase (AChE) inhibitor currently under development for the symptomatic treatment of Alzheimer disease. physostigmine heptyl 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 9702845-5 1998 Pharmacodynamic activity of eptastigmine was evaluated with an assay of AChE activity in red blood cells. physostigmine heptyl 28-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 9702845-11 1998 The mean (+/- SEM) maximum inhibition of AChE activity (Imax) was 14.5+/-3.3%, 20.4+/-2.3%, 28.7+/-2.9%, 45.2+/-1.3% and 53.6+/-2.9% after placebo, 8 mg, 20 mg, 32 mg, and 40 mg of eptastigmine, respectively. physostigmine heptyl 181-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 9702845-14 1998 Single oral doses of eptastigmine produce sustained, dose-related inhibition of AChE activity. physostigmine heptyl 21-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 9689452-7 1998 Enhanced AChE activity may increase dendritic arborization in the hippocampus and it may also play a role in improving cognitive functions observed in AD, following (-) deprenyl treatment. Selegiline 169-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 9871776-1 1998 Based upon modeling results obtained using the crystal structure of huperzine A in complex with acetylcholinesterase (AChE), two novel analogues of this potent AChE inhibitor were designed with phenol or catechol rings replacing the pyridone ring. huperzine A 68-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 9871776-1 1998 Based upon modeling results obtained using the crystal structure of huperzine A in complex with acetylcholinesterase (AChE), two novel analogues of this potent AChE inhibitor were designed with phenol or catechol rings replacing the pyridone ring. huperzine A 68-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 9871776-1 1998 Based upon modeling results obtained using the crystal structure of huperzine A in complex with acetylcholinesterase (AChE), two novel analogues of this potent AChE inhibitor were designed with phenol or catechol rings replacing the pyridone ring. huperzine A 68-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 9871776-1 1998 Based upon modeling results obtained using the crystal structure of huperzine A in complex with acetylcholinesterase (AChE), two novel analogues of this potent AChE inhibitor were designed with phenol or catechol rings replacing the pyridone ring. Phenol 194-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 9871776-1 1998 Based upon modeling results obtained using the crystal structure of huperzine A in complex with acetylcholinesterase (AChE), two novel analogues of this potent AChE inhibitor were designed with phenol or catechol rings replacing the pyridone ring. Phenol 194-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 9871776-1 1998 Based upon modeling results obtained using the crystal structure of huperzine A in complex with acetylcholinesterase (AChE), two novel analogues of this potent AChE inhibitor were designed with phenol or catechol rings replacing the pyridone ring. catechol 204-212 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 9871776-1 1998 Based upon modeling results obtained using the crystal structure of huperzine A in complex with acetylcholinesterase (AChE), two novel analogues of this potent AChE inhibitor were designed with phenol or catechol rings replacing the pyridone ring. Pyridones 233-241 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 9871776-1 1998 Based upon modeling results obtained using the crystal structure of huperzine A in complex with acetylcholinesterase (AChE), two novel analogues of this potent AChE inhibitor were designed with phenol or catechol rings replacing the pyridone ring. Pyridones 233-241 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 9871776-2 1998 From the modeling studies, the catechol analogue appeared capable of replacing one of the crystallographic waters bridging huperzine with Tyr 130 and Glu 199 of AChE. catechol 31-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-165 9871776-2 1998 From the modeling studies, the catechol analogue appeared capable of replacing one of the crystallographic waters bridging huperzine with Tyr 130 and Glu 199 of AChE. Glutamic Acid 150-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-165 9722429-9 1998 The results suggest the existence of a basal level of acetylcholine (ACh) release in the leech ganglion that is powerfully counteracted by endogenous AChE activity. Acetylcholine 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 9722429-9 1998 The results suggest the existence of a basal level of acetylcholine (ACh) release in the leech ganglion that is powerfully counteracted by endogenous AChE activity. Acetylcholine 69-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 9600872-8 1998 The results suggest the existence of a basal level of acetylcholine (ACh) release in the leech ganglion that is powerfully counteracted by endogenous AChE activity. Acetylcholine 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 9600872-8 1998 The results suggest the existence of a basal level of acetylcholine (ACh) release in the leech ganglion that is powerfully counteracted by endogenous AChE activity. Acetylcholine 69-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 9681667-4 1998 Acetylcholinesterase activity in red blood cells was assayed 24 h after drug administration as a biological marker of eptastigmine plasma concentrations. physostigmine heptyl 118-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 9681667-5 1998 RESULTS: Mean maximum acetylcholinesterase inhibition (Imax) was 39.9% after eptastigmine without food and 33.1% after eptastigmine with food. physostigmine heptyl 77-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 9681667-5 1998 RESULTS: Mean maximum acetylcholinesterase inhibition (Imax) was 39.9% after eptastigmine without food and 33.1% after eptastigmine with food. physostigmine heptyl 119-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 9681667-7 1998 Areas under the curve of acetylcholinesterase per cent inhibition from 0 to 8 h after drug administration (AUC0-8) were 198% h after eptastigmine without food and 124% h after eptastigmine with food. physostigmine heptyl 133-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 9681667-7 1998 Areas under the curve of acetylcholinesterase per cent inhibition from 0 to 8 h after drug administration (AUC0-8) were 198% h after eptastigmine without food and 124% h after eptastigmine with food. physostigmine heptyl 176-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 9681667-10 1998 CONCLUSIONS: The ingestion of food significantly reduces the bioavailability of eptastigmine estimated by the assay of red blood cell acetylcholinesterase activity. physostigmine heptyl 80-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 15616667-2 1998 The two major pharmacological principles of cholinergic therapy are 1) reduction of acetylcholine hydrolysis by means of acetylcholinesterase (AChE) inhibitors; and 2) direct stimulation of nicotinic or muscarinic receptors with selective agonists. Acetylcholine 84-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 15616667-2 1998 The two major pharmacological principles of cholinergic therapy are 1) reduction of acetylcholine hydrolysis by means of acetylcholinesterase (AChE) inhibitors; and 2) direct stimulation of nicotinic or muscarinic receptors with selective agonists. Acetylcholine 84-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 15616667-3 1998 Currently used AChE inhibitors are tacrine, donepezil hydrochloride, rivastigmine and metrifonate. Tacrine 35-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 15616667-3 1998 Currently used AChE inhibitors are tacrine, donepezil hydrochloride, rivastigmine and metrifonate. Donepezil 44-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 15616667-3 1998 Currently used AChE inhibitors are tacrine, donepezil hydrochloride, rivastigmine and metrifonate. Rivastigmine 69-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 15616667-3 1998 Currently used AChE inhibitors are tacrine, donepezil hydrochloride, rivastigmine and metrifonate. Trichlorfon 86-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 9576639-1 1998 INTRODUCTION: This study evaluates the activity of SDZ ENA 713, a centrally-selective acetylcholinesterase (AChE) inhibitor, in the cerebral spinal fluid (CSF) of patients with Alzheimer"s disease (AD), and its relationship to central and peripheral pharmacokinetic parameters. Sulfadiazine 51-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 9545588-9 1998 Removing the cysteine residue near the C-terminus (truncated AChE, delta TAChE) assuming to affect the refolding, did not increase the amount of active enzyme obtained after refolding. Cysteine 13-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 9549662-1 1998 Metrifonate is converted nonenzymatically to 2.2, dimethyl dichlorovinyl phosphate (DDVP), an inhibitor of acetylcholinesterase (AChE). Trichlorfon 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 9549662-1 1998 Metrifonate is converted nonenzymatically to 2.2, dimethyl dichlorovinyl phosphate (DDVP), an inhibitor of acetylcholinesterase (AChE). Trichlorfon 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 9549662-1 1998 Metrifonate is converted nonenzymatically to 2.2, dimethyl dichlorovinyl phosphate (DDVP), an inhibitor of acetylcholinesterase (AChE). Dichlorvos 50-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 9549662-1 1998 Metrifonate is converted nonenzymatically to 2.2, dimethyl dichlorovinyl phosphate (DDVP), an inhibitor of acetylcholinesterase (AChE). Dichlorvos 50-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 9549662-1 1998 Metrifonate is converted nonenzymatically to 2.2, dimethyl dichlorovinyl phosphate (DDVP), an inhibitor of acetylcholinesterase (AChE). Dichlorvos 84-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 9549662-1 1998 Metrifonate is converted nonenzymatically to 2.2, dimethyl dichlorovinyl phosphate (DDVP), an inhibitor of acetylcholinesterase (AChE). Dichlorvos 84-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 9611965-11 1998 DISCUSSION: The activity of enzyme acetylcholinesterase depends on functional state of the liver, as well as the therapy with some drugs (cyclophosphamide, ecothiopate etc.). Cyclophosphamide 138-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 9611965-11 1998 DISCUSSION: The activity of enzyme acetylcholinesterase depends on functional state of the liver, as well as the therapy with some drugs (cyclophosphamide, ecothiopate etc.). Echothiophate 156-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 9536457-1 1998 Chronic exposure to low levels of organophosphate (OP) compounds impairs acetylcholine (ACh) degradation by acetylcholinesterase (AChE) and, in humans, may produce lasting neurotoxicity affecting cognitive function. Organophosphates 34-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 9536457-1 1998 Chronic exposure to low levels of organophosphate (OP) compounds impairs acetylcholine (ACh) degradation by acetylcholinesterase (AChE) and, in humans, may produce lasting neurotoxicity affecting cognitive function. Organophosphates 34-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 9536457-1 1998 Chronic exposure to low levels of organophosphate (OP) compounds impairs acetylcholine (ACh) degradation by acetylcholinesterase (AChE) and, in humans, may produce lasting neurotoxicity affecting cognitive function. Acetylcholine 73-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 9536457-1 1998 Chronic exposure to low levels of organophosphate (OP) compounds impairs acetylcholine (ACh) degradation by acetylcholinesterase (AChE) and, in humans, may produce lasting neurotoxicity affecting cognitive function. Acetylcholine 73-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 9536457-1 1998 Chronic exposure to low levels of organophosphate (OP) compounds impairs acetylcholine (ACh) degradation by acetylcholinesterase (AChE) and, in humans, may produce lasting neurotoxicity affecting cognitive function. Acetylcholine 88-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 9536457-1 1998 Chronic exposure to low levels of organophosphate (OP) compounds impairs acetylcholine (ACh) degradation by acetylcholinesterase (AChE) and, in humans, may produce lasting neurotoxicity affecting cognitive function. Acetylcholine 88-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 9618943-0 1998 In vitro influence of phenylalanine on acetylcholinesterase activity and DNA. Phenylalanine 22-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 9618943-3 1998 AChE activity was measured spectrophotometrically after incubation with various Phe concentrations. Phenylalanine 80-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 9618943-5 1998 Phe was found to inhibit AChE almost 40%, at a concentration of 5 mM, whereas a 62.5% DNA peak exclusion (molecular interaction) was observed when Phe was incubated with DNA at a concentration of 3 mM. Phenylalanine 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 9454834-4 1998 Similar enhancement occurred in neurons expressing an insertion-inactivated human AChE-E6-IN protein, containing the same C terminus, and displaying indistinguishable immunochemical and electrophoretic migration properties from AChE-E6, but incapable of hydrolyzing acetylcholine. Acetylcholine 266-279 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 9477052-11 1998 CONCLUSIONS: Intra-articular injection of the acetylcholinesterase inhibitor neostigmine produced a moderate but significant analgesic effect. Neostigmine 77-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 9483538-1 1998 The involvement of muscarinic autoreceptors in the regulation of hippocampal acetylcholine levels during acetylcholinesterase inhibition was examined by perfusing the acetylcholinesterase inhibitor neostigmine bromide (10, 100 or 1000 nM) alone and in the presence of the muscarinic receptor antagonist atropine methylnitrate (10 microM), in resting and behaviourally-activated animals. Acetylcholine 77-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 9483538-8 1998 The handling-evoked increase in acetylcholine levels is only moderately affected by the level of acetylcholinesterase inhibition, despite the participation of autoreceptors in the handling effect at higher levels of acetylcholinesterase inhibition. Acetylcholine 32-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 9597187-2 1998 The conjunctive pharmacomodulation of huperzine A (carbobicyclic substructure) and tacrine (4-aminoquinoline substructure) led to compound 7jy, 2.5 times less active than tacrine as AChE inhibitor, but much more active than its (Z)-stereoisomer (7iy). Tacrine 83-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-186 9644580-0 1998 [Conformation aspects of stereospecificity of acetylcholinesterase hydrolysis of beta-methylcholine substrates]. beta-methylcholine 81-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 9547363-1 1998 Reactivation of organophosphate (OP)-inhibited acetylcholinesterase (AChE) by oximes is the primary reason for their effectiveness in the treatment of OP poisoning. Organophosphates 16-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 9547363-1 1998 Reactivation of organophosphate (OP)-inhibited acetylcholinesterase (AChE) by oximes is the primary reason for their effectiveness in the treatment of OP poisoning. Oximes 78-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 9547363-4 1998 To better understand the acceleration phenomenon, we examined ligand modulations of oxime-induced reactivation of methylphosphonylated AChE using 7-(methylethoxyphosphinyloxy)-1-methylquinolinium iodide and fetal bovine serum AChE. Oximes 84-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 9547363-4 1998 To better understand the acceleration phenomenon, we examined ligand modulations of oxime-induced reactivation of methylphosphonylated AChE using 7-(methylethoxyphosphinyloxy)-1-methylquinolinium iodide and fetal bovine serum AChE. Oximes 84-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-230 9547363-6 1998 Experiments were carried out with both soluble enzyme preparation and AChE conjugated to polyurethane. Polyurethanes 89-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 9547363-9 1998 Propidium slowed the reactivation of 7-(methylethoxyphosphinyloxy)-1- methylquinolinium iodide-inhibited AChE by all oximes. Propidium 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 9547363-9 1998 Propidium slowed the reactivation of 7-(methylethoxyphosphinyloxy)-1- methylquinolinium iodide-inhibited AChE by all oximes. 7-((methylethoxyphosphinyl)oxy)-1-methylquinolinium 37-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 9547363-9 1998 Propidium slowed the reactivation of 7-(methylethoxyphosphinyloxy)-1- methylquinolinium iodide-inhibited AChE by all oximes. Oximes 117-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 9547363-12 1998 Results offer possible explanations for the superiority of 1-(2-hydroxyiminomethyl-1-pyridinium)-1-(4-carboxy-aminopyridinium )-d imethyl ether hydrochloride over other oximes in the reactivation of specific AChE-OP conjugates. 1-(2-hydroxyiminomethyl-1-pyridinium)-1-(4-carboxy-aminopyridinium )-d imethyl ether hydrochloride 59-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-212 9635412-5 1998 Among compounds containing oxime functional groups only OPAB, having longer methylene chain and being more lipophylic than other oximes usually used in acetylcholinesterase (AChE) reactivation studies, was effective in decreasing the rate of aging on DFP-inhibited NTE. Oximes 27-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 9635412-5 1998 Among compounds containing oxime functional groups only OPAB, having longer methylene chain and being more lipophylic than other oximes usually used in acetylcholinesterase (AChE) reactivation studies, was effective in decreasing the rate of aging on DFP-inhibited NTE. opab 56-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 9635412-5 1998 Among compounds containing oxime functional groups only OPAB, having longer methylene chain and being more lipophylic than other oximes usually used in acetylcholinesterase (AChE) reactivation studies, was effective in decreasing the rate of aging on DFP-inhibited NTE. opab 56-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 9635412-5 1998 Among compounds containing oxime functional groups only OPAB, having longer methylene chain and being more lipophylic than other oximes usually used in acetylcholinesterase (AChE) reactivation studies, was effective in decreasing the rate of aging on DFP-inhibited NTE. Oximes 129-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 9635412-5 1998 Among compounds containing oxime functional groups only OPAB, having longer methylene chain and being more lipophylic than other oximes usually used in acetylcholinesterase (AChE) reactivation studies, was effective in decreasing the rate of aging on DFP-inhibited NTE. Oximes 129-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 9521743-9 1998 Direct measurements with the acylation site ligands huperzine A and m-(N,N, N-trimethylammonio)trifluoroacetophenone showed that bound propidium decreased the association rate constants 49- and 380-fold and the dissociation rate constants 10- and 60-fold, respectively, relative to the rate constants for these acylation site ligands with free AChE, in reasonable agreement with the nonequilibrium steric blockade model. huperzine A 52-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 344-348 9521743-9 1998 Direct measurements with the acylation site ligands huperzine A and m-(N,N, N-trimethylammonio)trifluoroacetophenone showed that bound propidium decreased the association rate constants 49- and 380-fold and the dissociation rate constants 10- and 60-fold, respectively, relative to the rate constants for these acylation site ligands with free AChE, in reasonable agreement with the nonequilibrium steric blockade model. m-(N,N,N-trimethylammonio)trifluoroacetophenone 68-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 344-348 9521743-9 1998 Direct measurements with the acylation site ligands huperzine A and m-(N,N, N-trimethylammonio)trifluoroacetophenone showed that bound propidium decreased the association rate constants 49- and 380-fold and the dissociation rate constants 10- and 60-fold, respectively, relative to the rate constants for these acylation site ligands with free AChE, in reasonable agreement with the nonequilibrium steric blockade model. Propidium 135-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 344-348 9521743-10 1998 We conclude that this model can account for the inhibition of AChE by small peripheral site ligands such as propidium without invoking any conformational interaction between the peripheral and acylation sites. Propidium 108-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 9871563-0 1998 Synthesis and activity studies of N-[omega-N"-(adamant-1"-yl)aminoalkyl]- 2-(4"-dimethylaminophenyl)acetamides: in the search of selective inhibitors for the different molecular forms of acetylcholinesterase. n-[omega-n"-(adamant-1"-yl)aminoalkyl]- 2-(4"-dimethylaminophenyl)acetamides 34-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-207 9871563-1 1998 A series of N-[omega-N"-(adamant-1"-yl)aminoalkyl]-2-(4"- dimethylaminophenyl)acetamides were synthesized and tested as acetylcholinesterase inhibitors. n-[omega-n"-(adamant-1"-yl)aminoalkyl]-2-(4"- dimethylaminophenyl)acetamides 12-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 9871590-1 1998 Based on the recently resolved crystal structure of complex (-)-huperzine A-AChE, we simulated the interaction between (-)-huperzine A analogues and AChE using molecular dynamics method. huperzine A 60-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 9871590-1 1998 Based on the recently resolved crystal structure of complex (-)-huperzine A-AChE, we simulated the interaction between (-)-huperzine A analogues and AChE using molecular dynamics method. huperzine A 60-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 9871590-1 1998 Based on the recently resolved crystal structure of complex (-)-huperzine A-AChE, we simulated the interaction between (-)-huperzine A analogues and AChE using molecular dynamics method. huperzine A 119-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 9871590-1 1998 Based on the recently resolved crystal structure of complex (-)-huperzine A-AChE, we simulated the interaction between (-)-huperzine A analogues and AChE using molecular dynamics method. huperzine A 119-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 9871590-2 1998 It was revealed that the methyl group at the three carbon bridge of (-)-huperzine A can form a weak hydrogen bond with the phenol hydroxyl oxygen of Tyr121 and the main-chain oxygen of Gly118 of AChE, respectively. Carbon 51-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 9871590-2 1998 It was revealed that the methyl group at the three carbon bridge of (-)-huperzine A can form a weak hydrogen bond with the phenol hydroxyl oxygen of Tyr121 and the main-chain oxygen of Gly118 of AChE, respectively. huperzine A 68-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 9871590-2 1998 It was revealed that the methyl group at the three carbon bridge of (-)-huperzine A can form a weak hydrogen bond with the phenol hydroxyl oxygen of Tyr121 and the main-chain oxygen of Gly118 of AChE, respectively. Hydrogen 100-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 9871590-2 1998 It was revealed that the methyl group at the three carbon bridge of (-)-huperzine A can form a weak hydrogen bond with the phenol hydroxyl oxygen of Tyr121 and the main-chain oxygen of Gly118 of AChE, respectively. Oxygen 139-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 9871590-2 1998 It was revealed that the methyl group at the three carbon bridge of (-)-huperzine A can form a weak hydrogen bond with the phenol hydroxyl oxygen of Tyr121 and the main-chain oxygen of Gly118 of AChE, respectively. Oxygen 175-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 9592930-2 1998 Metabolism of an AChE inhibitor, carbofuran was studied. Carbofuran 33-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 9587020-0 1998 Reactivating potency of obidoxime, pralidoxime, HI 6 and HLo 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds. Obidoxime Chloride 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 9587020-0 1998 Reactivating potency of obidoxime, pralidoxime, HI 6 and HLo 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds. pralidoxime 35-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 9587020-0 1998 Reactivating potency of obidoxime, pralidoxime, HI 6 and HLo 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds. Organophosphorus Compounds 131-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 9587020-4 1998 Since oximes are believed to act primarily through reactivation of inhibited acetylcholinesterase (AChE) and erythrocyte AChE is regarded to be a good marker for the synaptic enzyme, the reactivating potency can be investigated with human erythrocyte AChE in vitro. Oximes 6-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 9587020-4 1998 Since oximes are believed to act primarily through reactivation of inhibited acetylcholinesterase (AChE) and erythrocyte AChE is regarded to be a good marker for the synaptic enzyme, the reactivating potency can be investigated with human erythrocyte AChE in vitro. Oximes 6-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 9587020-5 1998 The present study was undertaken to evaluate the ability of various oximes at concentrations therapeutically relevant in humans to reactivate human erythrocyte AChE inhibited by different nerve agents. Oximes 68-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 9587020-6 1998 Isolated human erythrocyte AChE was inhibited with soman, sarin, cyclosarin, tabun or VX for 30 min and reactivated in the absence of inhibitory activity over 5-60 min by obidoxime, pralidoxime, HI 6 or HLo 7 (10 and 30 microM). cyclohexyl methylphosphonofluoridate 65-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 9587020-6 1998 Isolated human erythrocyte AChE was inhibited with soman, sarin, cyclosarin, tabun or VX for 30 min and reactivated in the absence of inhibitory activity over 5-60 min by obidoxime, pralidoxime, HI 6 or HLo 7 (10 and 30 microM). Obidoxime Chloride 171-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 9587020-6 1998 Isolated human erythrocyte AChE was inhibited with soman, sarin, cyclosarin, tabun or VX for 30 min and reactivated in the absence of inhibitory activity over 5-60 min by obidoxime, pralidoxime, HI 6 or HLo 7 (10 and 30 microM). pralidoxime 182-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 9587020-6 1998 Isolated human erythrocyte AChE was inhibited with soman, sarin, cyclosarin, tabun or VX for 30 min and reactivated in the absence of inhibitory activity over 5-60 min by obidoxime, pralidoxime, HI 6 or HLo 7 (10 and 30 microM). asoxime chloride 195-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 9587020-6 1998 Isolated human erythrocyte AChE was inhibited with soman, sarin, cyclosarin, tabun or VX for 30 min and reactivated in the absence of inhibitory activity over 5-60 min by obidoxime, pralidoxime, HI 6 or HLo 7 (10 and 30 microM). HLo 7 203-208 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 9587020-8 1998 The reactivation of human AChE by oximes was dependent on the organophosphate used. Oximes 34-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 9587020-8 1998 The reactivation of human AChE by oximes was dependent on the organophosphate used. Organophosphates 62-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 9587020-10 1998 Obidoxime and pralidoxime were weak reactivators of cyclosarin-inhibited AChE. Obidoxime Chloride 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 9587020-10 1998 Obidoxime and pralidoxime were weak reactivators of cyclosarin-inhibited AChE. pralidoxime 14-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 9587020-10 1998 Obidoxime and pralidoxime were weak reactivators of cyclosarin-inhibited AChE. cyclohexyl methylphosphonofluoridate 52-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 9587020-11 1998 Only obidoxime and HLo 7 reactivated tabun-inhibited AChE partially (20%), while pralidoxime and HI 6 were almost ineffective (5%). Obidoxime Chloride 5-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 9587781-3 1998 We have measured the direct effects of antimony compounds including stibine on the activity of plasma cholinesterase, red blood cell acetylcholinesterase (AChE) and mouse neuronal AChE in vitro. stibine 68-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 9576639-7 1998 CONCLUSION: Rapid, sustained, dose-dependent inhibition of CSF AChE suggests that SDZ ENA 713 has therapeutic potential in AD patients. Sulfadiazine 82-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 9576639-7 1998 CONCLUSION: Rapid, sustained, dose-dependent inhibition of CSF AChE suggests that SDZ ENA 713 has therapeutic potential in AD patients. Rivastigmine 86-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 9448738-0 1998 Combined effect of organophosphorus hydrolase and oxime on the reactivation rate of diethylphosphoryl-acetylcholinesterase conjugates. Oximes 50-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 9448738-1 1998 Reactivation of inhibited acetylcholinesterase (AChE) is essential for rapid recovery after organophosphate (OP) poisoning. Organophosphates 92-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 9448738-1 1998 Reactivation of inhibited acetylcholinesterase (AChE) is essential for rapid recovery after organophosphate (OP) poisoning. Organophosphates 92-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 9448738-6 1998 (OPHps) to prevent reinhibition of P2S-reactivated AChE by excess OPs. P-2 35-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 9448738-7 1998 The kinetic parameters of the reactivation of a series of diethylphosphoryl-AChE (DEP--AChE) conjugates, obtained by the use of various diethylphosphates, were determined and compared with the rates of reactivation in the presence of OPHps, with and without the OP inhibitors in the reactivation medium. diethyl phosphate 136-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 9448738-7 1998 The kinetic parameters of the reactivation of a series of diethylphosphoryl-AChE (DEP--AChE) conjugates, obtained by the use of various diethylphosphates, were determined and compared with the rates of reactivation in the presence of OPHps, with and without the OP inhibitors in the reactivation medium. diethyl phosphate 136-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 9425034-2 1998 The mechanism of inhibition of acetylcholinesterase by these monoclonal antibodies was further investigated by determining their effect on (i) substrate inhibition due to the binding of excess substrate to the peripheral anionic site and (ii) binding of peripheral anionic site ligands, such as propidium and fasciculin. Propidium 295-304 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 9425034-4 1998 The results also show that propidium clearly slowed the inhibition of fetal bovine serum acetylcholinesterase by all six inhibitory monoclonal antibodies but to different levels. Propidium 27-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 9475825-6 1998 DATA SYNTHESIS: Donepezil is a cholinesterase inhibitor that is selective and specific for acetylcholinesterase. Donepezil 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 9477222-0 1998 Change in the mode of inhibition of acetylcholinesterase by (4-nitrophenyl)sulfonoxyl derivatives of conformationally constrained choline analogues. (4-nitrophenyl)sulfonoxyl 60-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 9489729-2 1998 Systemic administration of d-amphetamine (2 or 10 mg/kg) increased the striatal output of ACh when the AChE inhibitor neostigmine (0.1 microM) was present in the perfusion fluid. Dextroamphetamine 27-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 9489729-2 1998 Systemic administration of d-amphetamine (2 or 10 mg/kg) increased the striatal output of ACh when the AChE inhibitor neostigmine (0.1 microM) was present in the perfusion fluid. Acetylcholine 90-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 9489729-2 1998 Systemic administration of d-amphetamine (2 or 10 mg/kg) increased the striatal output of ACh when the AChE inhibitor neostigmine (0.1 microM) was present in the perfusion fluid. Neostigmine 118-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 9568379-0 1998 Effects of hexamethonium, phenothiazines, propranolol and ephedrine on acetylcholinesterase carbamylation by physostigmine, aldicarb and carbaryl: interaction between the active site and the functionally distinct peripheral sites in acetylcholinesterase. Hexamethonium 11-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 9568379-0 1998 Effects of hexamethonium, phenothiazines, propranolol and ephedrine on acetylcholinesterase carbamylation by physostigmine, aldicarb and carbaryl: interaction between the active site and the functionally distinct peripheral sites in acetylcholinesterase. Phenothiazines 26-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 9568379-0 1998 Effects of hexamethonium, phenothiazines, propranolol and ephedrine on acetylcholinesterase carbamylation by physostigmine, aldicarb and carbaryl: interaction between the active site and the functionally distinct peripheral sites in acetylcholinesterase. Propranolol 42-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 9568379-0 1998 Effects of hexamethonium, phenothiazines, propranolol and ephedrine on acetylcholinesterase carbamylation by physostigmine, aldicarb and carbaryl: interaction between the active site and the functionally distinct peripheral sites in acetylcholinesterase. Ephedrine 58-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 9568379-0 1998 Effects of hexamethonium, phenothiazines, propranolol and ephedrine on acetylcholinesterase carbamylation by physostigmine, aldicarb and carbaryl: interaction between the active site and the functionally distinct peripheral sites in acetylcholinesterase. Ephedrine 58-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-253 9568379-0 1998 Effects of hexamethonium, phenothiazines, propranolol and ephedrine on acetylcholinesterase carbamylation by physostigmine, aldicarb and carbaryl: interaction between the active site and the functionally distinct peripheral sites in acetylcholinesterase. Physostigmine 109-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 9568379-0 1998 Effects of hexamethonium, phenothiazines, propranolol and ephedrine on acetylcholinesterase carbamylation by physostigmine, aldicarb and carbaryl: interaction between the active site and the functionally distinct peripheral sites in acetylcholinesterase. Physostigmine 109-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-253 9568379-0 1998 Effects of hexamethonium, phenothiazines, propranolol and ephedrine on acetylcholinesterase carbamylation by physostigmine, aldicarb and carbaryl: interaction between the active site and the functionally distinct peripheral sites in acetylcholinesterase. Aldicarb 124-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 9718228-1 1998 The promising results of early trials in Alzheimer"s disease with the acetylcholinesterase inhibitor metrifonate prompted initiation of the Metrifonate in ALzheimer"s Trial (MALT). Trichlorfon 101-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 9718228-1 1998 The promising results of early trials in Alzheimer"s disease with the acetylcholinesterase inhibitor metrifonate prompted initiation of the Metrifonate in ALzheimer"s Trial (MALT). Trichlorfon 140-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 9718229-2 1998 A double-blind, placebo-controlled, 26-week study of the AChE inhibitor metrifonate using the NeuroPsychiatric Inventory (NPI) to assess the effects of treatment on neuropsychiatric symptoms observed statistically significant mean change differences favouring treatment in the total NPI score and in symptoms of depression, apathy and hallucinations, as well as a nearly significant difference in aberrant motor behaviours. Trichlorfon 72-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 9853200-1 1998 Donepezil HCI is a piperidine-based reversible acetylcholinesterase (AChE) inhibitor, chemically distinct from other cholinesterase (ChE) inhibitors and rationally designed to treat the symptoms of Alzheimer"s disease (AD). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 9853200-1 1998 Donepezil HCI is a piperidine-based reversible acetylcholinesterase (AChE) inhibitor, chemically distinct from other cholinesterase (ChE) inhibitors and rationally designed to treat the symptoms of Alzheimer"s disease (AD). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 9853200-1 1998 Donepezil HCI is a piperidine-based reversible acetylcholinesterase (AChE) inhibitor, chemically distinct from other cholinesterase (ChE) inhibitors and rationally designed to treat the symptoms of Alzheimer"s disease (AD). piperidine 19-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 9853200-1 1998 Donepezil HCI is a piperidine-based reversible acetylcholinesterase (AChE) inhibitor, chemically distinct from other cholinesterase (ChE) inhibitors and rationally designed to treat the symptoms of Alzheimer"s disease (AD). piperidine 19-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 9606620-0 1998 Electron microscopic localization of acetylcholinesterase activity in the central nervous system: chemical basis of a catalytic activity of Hatchett"s brown (cupric ferrocyanide) precipitate revealed by 3,3"-diaminobenzidine. cupric ferrocyanide 158-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 9606620-0 1998 Electron microscopic localization of acetylcholinesterase activity in the central nervous system: chemical basis of a catalytic activity of Hatchett"s brown (cupric ferrocyanide) precipitate revealed by 3,3"-diaminobenzidine. 3,3'-Diaminobenzidine 203-224 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 9606620-4 1998 The visualization of acetylcholinesterase activity is made in a secondary reaction where diaminobenzidine (DAB) is oxidized in the presence of hydrogen peroxide by the peroxidase-like activity of the histochemical precipitate. 4,4'-Dihydrazino-biphenyl 89-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 9606620-4 1998 The visualization of acetylcholinesterase activity is made in a secondary reaction where diaminobenzidine (DAB) is oxidized in the presence of hydrogen peroxide by the peroxidase-like activity of the histochemical precipitate. 3,3'-Diaminobenzidine 107-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 9606620-4 1998 The visualization of acetylcholinesterase activity is made in a secondary reaction where diaminobenzidine (DAB) is oxidized in the presence of hydrogen peroxide by the peroxidase-like activity of the histochemical precipitate. Hydrogen Peroxide 143-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 9720485-1 1998 Metrifonate, administered orally to patients with probable Alzheimer"s disease in a once-daily dose, readily enters the brain and inhibits brain acetylcholinesterase (AChE) activity in a dose-dependent fashion. Trichlorfon 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 9720485-1 1998 Metrifonate, administered orally to patients with probable Alzheimer"s disease in a once-daily dose, readily enters the brain and inhibits brain acetylcholinesterase (AChE) activity in a dose-dependent fashion. Trichlorfon 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 10942971-9 1998 PMSF, a specific inhibitor for serine proteases and mammalian acetylcholinesterase, completely inhibited the formation of flumazenil -acid and the flumazenil methylester at a concentration of 100 microM. Phenylmethylsulfonyl Fluoride 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 10942971-9 1998 PMSF, a specific inhibitor for serine proteases and mammalian acetylcholinesterase, completely inhibited the formation of flumazenil -acid and the flumazenil methylester at a concentration of 100 microM. Ro 15-3890 122-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 9720485-2 1998 Metrifonate is a prodrug, converted non-enzymatically to 2,2-dichlorovinyl dimethyl phosphate, a long-acting inhibitor of AChE that produces stable enzyme inhibition over time. Trichlorfon 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 9720485-2 1998 Metrifonate is a prodrug, converted non-enzymatically to 2,2-dichlorovinyl dimethyl phosphate, a long-acting inhibitor of AChE that produces stable enzyme inhibition over time. Dichlorvos 57-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 10942971-9 1998 PMSF, a specific inhibitor for serine proteases and mammalian acetylcholinesterase, completely inhibited the formation of flumazenil -acid and the flumazenil methylester at a concentration of 100 microM. Flumazenil 122-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 9585171-1 1998 Metrifonate, a pro-drug that is transformed non-enzymatically into a potent inhibitor of acetylcholinesterase (AChE), has been used in the tropics for over 30 years for the treatment of schistosomiasis. Trichlorfon 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 9771828-4 1998 By contrast, studies with AChE inhibitors--tacrine and donepezil--have been promising. Tacrine 43-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 9771828-4 1998 By contrast, studies with AChE inhibitors--tacrine and donepezil--have been promising. Donepezil 55-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 9493175-1 1998 Acetylcholinesterase (AChE) is the enzyme responsible for the hydrolysis of the neurotransmitter acetylcholine in the central nervous system. Acetylcholine 97-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 9585171-1 1998 Metrifonate, a pro-drug that is transformed non-enzymatically into a potent inhibitor of acetylcholinesterase (AChE), has been used in the tropics for over 30 years for the treatment of schistosomiasis. Trichlorfon 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 9585171-2 1998 A pilot study, and Phase I and Phase II studies of metrifonate in Alzheimer"s disease (AD) patients conducted prior to the current study showed benign, dose-dependent adverse event profiles consisting primarily of gastrointestinal events, optimal daily dosing with a loading phase (in the absence of a loading dose phase, 6-8 weeks were required to attain steady-state AChE inhibition levels), and an improvement in Alzheimer"s Disease Assessment Scale (ADAS) scores. Trichlorfon 51-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 369-373 9428950-2 1997 Donepezil is a synthetic noncovalent reversible inhibitor of acetylcholinesterase (AChE) for the treatment of mild to moderate dementia associated with Alzheimer"s disease. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 9428950-2 1997 Donepezil is a synthetic noncovalent reversible inhibitor of acetylcholinesterase (AChE) for the treatment of mild to moderate dementia associated with Alzheimer"s disease. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 9428950-3 1997 In contrast to tacrine hydrochloride, the only comparable agent currently approved by FDA, donepezil exhibits a relatively high degree of selectivity for neuronal AChE as opposed to butyrylcholinesterase. Donepezil 91-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 9398183-1 1997 Amino acid sequence alignments of cholinesterases revealed that 6 of 14 aromatic amino acid residues lining the active center gorge of acetylcholinesterase are replaced by aliphatic amino acid residues in butyrylcholinesterase. Amino Acids, Aromatic 72-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 9398183-2 1997 The Y337 (F330) in mammalian acetylcholinesterase, which is replaced by A328 in human butyrylcholinesterase, is implicated in the binding of ligands such as huperzine A, edrophonium, and acridines and one end of bisquaternary compounds such as BW284C51 and decamethonium. a328 72-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 9398183-2 1997 The Y337 (F330) in mammalian acetylcholinesterase, which is replaced by A328 in human butyrylcholinesterase, is implicated in the binding of ligands such as huperzine A, edrophonium, and acridines and one end of bisquaternary compounds such as BW284C51 and decamethonium. huperzine A 157-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 9568379-0 1998 Effects of hexamethonium, phenothiazines, propranolol and ephedrine on acetylcholinesterase carbamylation by physostigmine, aldicarb and carbaryl: interaction between the active site and the functionally distinct peripheral sites in acetylcholinesterase. Carbaryl 137-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 9568379-0 1998 Effects of hexamethonium, phenothiazines, propranolol and ephedrine on acetylcholinesterase carbamylation by physostigmine, aldicarb and carbaryl: interaction between the active site and the functionally distinct peripheral sites in acetylcholinesterase. Carbaryl 137-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-253 9568379-1 1998 Physostigmine, aldicarb and carbaryl were potent inhibitors of acetylcholinesterase (AChE). Physostigmine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 9568379-1 1998 Physostigmine, aldicarb and carbaryl were potent inhibitors of acetylcholinesterase (AChE). Physostigmine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 9398183-2 1997 The Y337 (F330) in mammalian acetylcholinesterase, which is replaced by A328 in human butyrylcholinesterase, is implicated in the binding of ligands such as huperzine A, edrophonium, and acridines and one end of bisquaternary compounds such as BW284C51 and decamethonium. Edrophonium 170-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 9568379-1 1998 Physostigmine, aldicarb and carbaryl were potent inhibitors of acetylcholinesterase (AChE). Aldicarb 15-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 9493175-1 1998 Acetylcholinesterase (AChE) is the enzyme responsible for the hydrolysis of the neurotransmitter acetylcholine in the central nervous system. Acetylcholine 97-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 9568379-1 1998 Physostigmine, aldicarb and carbaryl were potent inhibitors of acetylcholinesterase (AChE). Aldicarb 15-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 9568379-1 1998 Physostigmine, aldicarb and carbaryl were potent inhibitors of acetylcholinesterase (AChE). Carbaryl 28-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 9398183-2 1997 The Y337 (F330) in mammalian acetylcholinesterase, which is replaced by A328 in human butyrylcholinesterase, is implicated in the binding of ligands such as huperzine A, edrophonium, and acridines and one end of bisquaternary compounds such as BW284C51 and decamethonium. Acridines 187-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 9398183-2 1997 The Y337 (F330) in mammalian acetylcholinesterase, which is replaced by A328 in human butyrylcholinesterase, is implicated in the binding of ligands such as huperzine A, edrophonium, and acridines and one end of bisquaternary compounds such as BW284C51 and decamethonium. Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide 244-252 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 9398183-2 1997 The Y337 (F330) in mammalian acetylcholinesterase, which is replaced by A328 in human butyrylcholinesterase, is implicated in the binding of ligands such as huperzine A, edrophonium, and acridines and one end of bisquaternary compounds such as BW284C51 and decamethonium. decamethonium 257-270 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 9568379-1 1998 Physostigmine, aldicarb and carbaryl were potent inhibitors of acetylcholinesterase (AChE). Carbaryl 28-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 9568379-2 1998 The physostigmine-inhibited AChE fluoresced at 300 nm excitation and 500 nm emission wavelengths, but the aldicarb and carbaryl inhibited enzyme did not. Physostigmine 4-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 9568379-4 1998 The fluorescence intensity of physostigmine-inhibited AChE decreased with increasing the substrate (acetylthiocholine) concentration, thus indicating that physostigmine binding to the active site is essential for the development of fluorescence. Physostigmine 30-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 9568379-4 1998 The fluorescence intensity of physostigmine-inhibited AChE decreased with increasing the substrate (acetylthiocholine) concentration, thus indicating that physostigmine binding to the active site is essential for the development of fluorescence. Acetylthiocholine 100-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 9568379-4 1998 The fluorescence intensity of physostigmine-inhibited AChE decreased with increasing the substrate (acetylthiocholine) concentration, thus indicating that physostigmine binding to the active site is essential for the development of fluorescence. Physostigmine 155-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 9568379-5 1998 Thus, the physostigmine-inhibited AChE fluoresces due to the binding of trimethylpyrrolo[2,3-b]indol (TMPI) moiety, formed by the hydrolysis of physostigmine, to a peripheral site in AChE. Physostigmine 10-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 9568379-5 1998 Thus, the physostigmine-inhibited AChE fluoresces due to the binding of trimethylpyrrolo[2,3-b]indol (TMPI) moiety, formed by the hydrolysis of physostigmine, to a peripheral site in AChE. Physostigmine 10-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-187 9568379-5 1998 Thus, the physostigmine-inhibited AChE fluoresces due to the binding of trimethylpyrrolo[2,3-b]indol (TMPI) moiety, formed by the hydrolysis of physostigmine, to a peripheral site in AChE. trimethylpyrrolo[2,3-b]indol 72-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 9568379-5 1998 Thus, the physostigmine-inhibited AChE fluoresces due to the binding of trimethylpyrrolo[2,3-b]indol (TMPI) moiety, formed by the hydrolysis of physostigmine, to a peripheral site in AChE. trimethylpyrrolo[2,3-b]indol 72-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-187 9568379-5 1998 Thus, the physostigmine-inhibited AChE fluoresces due to the binding of trimethylpyrrolo[2,3-b]indol (TMPI) moiety, formed by the hydrolysis of physostigmine, to a peripheral site in AChE. tmpi 102-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 9568379-5 1998 Thus, the physostigmine-inhibited AChE fluoresces due to the binding of trimethylpyrrolo[2,3-b]indol (TMPI) moiety, formed by the hydrolysis of physostigmine, to a peripheral site in AChE. tmpi 102-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-187 9568379-5 1998 Thus, the physostigmine-inhibited AChE fluoresces due to the binding of trimethylpyrrolo[2,3-b]indol (TMPI) moiety, formed by the hydrolysis of physostigmine, to a peripheral site in AChE. Physostigmine 144-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 9398183-5 1997 Volume calculations for the active site gorge showed that the poor inhibitory activity of ethopropazine toward acetylcholinesterase was due to the smaller dimension of the active site gorge which was unable to accommodate the bulky inhibitor molecule. profenamine 90-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 9398183-6 1997 The volume of the butyrylcholinesterase active site gorge is approximately 200 A3 larger than that of the acetylcholinesterase gorge, which allows the accommodation of ethopropazine in two different orientations as demonstrated by rigid-body refinement and molecular dynamics calculations. profenamine 168-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 9568379-5 1998 Thus, the physostigmine-inhibited AChE fluoresces due to the binding of trimethylpyrrolo[2,3-b]indol (TMPI) moiety, formed by the hydrolysis of physostigmine, to a peripheral site in AChE. Physostigmine 144-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-187 9493175-4 1998 In the present work, we have studied A beta-AChE interactions using the crosslinker reagent disuccinimidyl suberate (DSS), in the presence of [125I]-A beta peptide. disuccinimidyl suberate 117-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 9568379-7 1998 This suggests that dialysis dissociates the AChE-TMPI complex much faster than it reactivates the carbamylated AChE. tmpi 49-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 9568379-7 1998 This suggests that dialysis dissociates the AChE-TMPI complex much faster than it reactivates the carbamylated AChE. tmpi 49-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 9389333-4 1997 The AChE activities of their red blood cells and brains were dose-dependently reduced by intravenous BIMP. Diisopropyl dimethylpyrophosphonate 101-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 9568379-8 1998 Ephedrine, propranolol and phenothiazines including trifluoparazine (TPZ) caused non-competitive inhibition, while hexamethonium caused an uncompetitive inhibition of AChE activity. Ephedrine 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 9568379-8 1998 Ephedrine, propranolol and phenothiazines including trifluoparazine (TPZ) caused non-competitive inhibition, while hexamethonium caused an uncompetitive inhibition of AChE activity. Propranolol 11-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 9568379-8 1998 Ephedrine, propranolol and phenothiazines including trifluoparazine (TPZ) caused non-competitive inhibition, while hexamethonium caused an uncompetitive inhibition of AChE activity. Phenothiazines 27-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 9568379-8 1998 Ephedrine, propranolol and phenothiazines including trifluoparazine (TPZ) caused non-competitive inhibition, while hexamethonium caused an uncompetitive inhibition of AChE activity. trifluoparazine 52-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 9568379-8 1998 Ephedrine, propranolol and phenothiazines including trifluoparazine (TPZ) caused non-competitive inhibition, while hexamethonium caused an uncompetitive inhibition of AChE activity. O-Phosphono-N-(5-Sulfanylpentanoyl)-L-Threonine 69-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 9568379-8 1998 Ephedrine, propranolol and phenothiazines including trifluoparazine (TPZ) caused non-competitive inhibition, while hexamethonium caused an uncompetitive inhibition of AChE activity. Hexamethonium 115-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 9568379-10 1998 The fluorescence intensity of TPZ-AChE complex was effectively decreased by ephedrine, but not by propranolol or hexamethonium. Ephedrine 76-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 9568379-10 1998 The fluorescence intensity of TPZ-AChE complex was effectively decreased by ephedrine, but not by propranolol or hexamethonium. Propranolol 98-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 9568379-11 1998 This indicates that TPZ and ephedrine bind to the same site in AChE which is different from the site/or sites to which propranolol or hexamethonium bind. O-Phosphono-N-(5-Sulfanylpentanoyl)-L-Threonine 20-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 9568379-11 1998 This indicates that TPZ and ephedrine bind to the same site in AChE which is different from the site/or sites to which propranolol or hexamethonium bind. Ephedrine 28-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 9568379-12 1998 Hexamethonium protected AChE from inhibition by carbamates and decreased the fluorescence intensity of the physostigmine-inhibited AChE. Hexamethonium 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 9568379-12 1998 Hexamethonium protected AChE from inhibition by carbamates and decreased the fluorescence intensity of the physostigmine-inhibited AChE. Hexamethonium 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 9568379-12 1998 Hexamethonium protected AChE from inhibition by carbamates and decreased the fluorescence intensity of the physostigmine-inhibited AChE. Carbamates 48-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 9568379-12 1998 Hexamethonium protected AChE from inhibition by carbamates and decreased the fluorescence intensity of the physostigmine-inhibited AChE. Physostigmine 107-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 9568380-2 1998 Me is a potent inhibitor, while Ac is a poor inhibitor of mammalian AChE (mAChE). acephate 32-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 9568380-17 1998 We propose that, similar to a previous model for cationic inhibitors of AChE (13), the P = O delta- group of Me forms hydrogen bonds within the oxyanion-hole causing the leaving group (-SCH3) to orient towards the "gorge" opening. methamidophos 109-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 9568380-17 1998 We propose that, similar to a previous model for cationic inhibitors of AChE (13), the P = O delta- group of Me forms hydrogen bonds within the oxyanion-hole causing the leaving group (-SCH3) to orient towards the "gorge" opening. Hydrogen 118-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 9568380-20 1998 This destabilizes the binding of Ac to the active center, resulting in reduced AChE phosphorylation. acephate 33-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 9389333-5 1997 After preparation of experimental BIMP-exposed human red blood cells, BIMP-bound acetylcholinesterase (AChE) was solubilized from erythrocyte membranes, purified by immunoaffinity chromatography, digested with trypsin, and the sarin hydrolysis products bound to AChE were released by alkaline phosphatase digestion. Diisopropyl dimethylpyrophosphonate 34-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 9389333-5 1997 After preparation of experimental BIMP-exposed human red blood cells, BIMP-bound acetylcholinesterase (AChE) was solubilized from erythrocyte membranes, purified by immunoaffinity chromatography, digested with trypsin, and the sarin hydrolysis products bound to AChE were released by alkaline phosphatase digestion. Diisopropyl dimethylpyrophosphonate 34-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 9474819-2 1997 This system was initially employed in studies to stabilise the enzyme acetylcholinesterase (AChE), which was immobilised on a cobalt phthalocyanine screen-printed carbon electrode to form a biosensor. cobalt phthalocyanine 126-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 9474819-2 1997 This system was initially employed in studies to stabilise the enzyme acetylcholinesterase (AChE), which was immobilised on a cobalt phthalocyanine screen-printed carbon electrode to form a biosensor. cobalt phthalocyanine 126-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 9474819-2 1997 This system was initially employed in studies to stabilise the enzyme acetylcholinesterase (AChE), which was immobilised on a cobalt phthalocyanine screen-printed carbon electrode to form a biosensor. Carbon 163-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 9474819-2 1997 This system was initially employed in studies to stabilise the enzyme acetylcholinesterase (AChE), which was immobilised on a cobalt phthalocyanine screen-printed carbon electrode to form a biosensor. Carbon 163-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 9474819-5 1997 The detection limits were 7 x 10(-11) mol dm-3 (for 1 U of AChE) and 4 x 10(-11) mol dm-3 (for 0.05 U of AChE), respectively, which are better than for other electrochemical methods. Dm-3 42-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 9474819-5 1997 The detection limits were 7 x 10(-11) mol dm-3 (for 1 U of AChE) and 4 x 10(-11) mol dm-3 (for 0.05 U of AChE), respectively, which are better than for other electrochemical methods. Dm-3 85-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 9427520-1 1997 Here, we report that the catalytic subunit of cAMP-dependent protein kinase (PKA) but not casein kinase II or protein kinase C phosphorylates recombinant human acetylcholinesterase (AChE) in vitro. Cyclic AMP 46-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-180 9494555-0 1997 Estimation and correlation of IC50 for the inhibition of human erythrocyte acetylcholinesterase by cis-diamminediaquaplatinum (II). cis-diamminediaquaplatinum 99-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 9494555-2 1997 It has been recently reported that cisplatin itself has the ability to inhibit the AChE activity in vitro [Al-Jafari, et al, 1995; Kamal and Al-Jafari, 1996]. Cisplatin 35-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 9494555-4 1997 It was found that 0.0-20.0% and 53.8-94.5% AChE inhibition takes place at 3.0 to 60 minutes after 0.025 and 0.40 mM DDP administration, respectively. ddp 116-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 9494555-6 1997 The DDP has 1025 and 67 times higher inhibitory potency than cisplatin for human erythrocyte AChE at 3.0 and 60.0 minutes reaction time respectively. Cisplatin 61-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 9494556-0 1997 Kinetics of human erythrocyte acetylcholinesterase inhibition by cis-diamminediaquaplatinum (II). cis-diamminediaquaplatinum 65-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 9494556-1 1997 This work addresses the kinetic studies for the interaction of cis-diamminediaquaplatinum (II) ?cis-[Pt(NH3)2(H2O)2]2+?, (DDP) with human erythrocyte acetylcholinesterase (AChE). cis-diamminediaquaplatinum (ii) 63-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 9494556-1 1997 This work addresses the kinetic studies for the interaction of cis-diamminediaquaplatinum (II) ?cis-[Pt(NH3)2(H2O)2]2+?, (DDP) with human erythrocyte acetylcholinesterase (AChE). cis-diamminediaquaplatinum (ii) 63-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-176 9494556-2 1997 The Ks for the hydrolysis of acetylthiocholine iodide (ASCh) by AChE was 0.077 mM in the control system, the value decreased by 14-38% in the DDP treated systems. Potassium 4-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 9494556-2 1997 The Ks for the hydrolysis of acetylthiocholine iodide (ASCh) by AChE was 0.077 mM in the control system, the value decreased by 14-38% in the DDP treated systems. acetylthiocholine iodide 29-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 9494556-2 1997 The Ks for the hydrolysis of acetylthiocholine iodide (ASCh) by AChE was 0.077 mM in the control system, the value decreased by 14-38% in the DDP treated systems. asch 55-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 9494556-2 1997 The Ks for the hydrolysis of acetylthiocholine iodide (ASCh) by AChE was 0.077 mM in the control system, the value decreased by 14-38% in the DDP treated systems. Cisplatin 142-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 9427520-1 1997 Here, we report that the catalytic subunit of cAMP-dependent protein kinase (PKA) but not casein kinase II or protein kinase C phosphorylates recombinant human acetylcholinesterase (AChE) in vitro. Cyclic AMP 46-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-186 9427520-4 1997 Enhancement of acetylthiocholine hydrolysis also occurred with Torpedo AChE, which has no consensus motif for PKA phosphorylation. Acetylthiocholine 15-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 9427520-6 1997 In vivo suppression of the acetylcholine hydrolyzing activity of AChE and consequent impairment in cholinergic neurotransmission occur under exposure to both natural and pharmacological compounds, including organophosphate and carbamate insecticides and chemical warfare agents. Acetylcholine 27-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 9427520-6 1997 In vivo suppression of the acetylcholine hydrolyzing activity of AChE and consequent impairment in cholinergic neurotransmission occur under exposure to both natural and pharmacological compounds, including organophosphate and carbamate insecticides and chemical warfare agents. Organophosphates 207-222 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 9427520-6 1997 In vivo suppression of the acetylcholine hydrolyzing activity of AChE and consequent impairment in cholinergic neurotransmission occur under exposure to both natural and pharmacological compounds, including organophosphate and carbamate insecticides and chemical warfare agents. Carbamates 227-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 9427520-7 1997 Phosphorylation of AChE may possibly offer a rapid feedback mechanism that can compensate for impairments in cholinergic neurotransmission, modulating the hydrolytic activity of this enzyme and enabling acetylcholine hydrolysis to proceed under such challenges. Acetylcholine 203-216 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 9351648-1 1997 Analysis of 139 CSF samples from living subjects, using iso-electric focusing in polyacrylamide gels, demonstrated an anomalous molecular form of acetylcholinesterase (AChE). polyacrylamide 81-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-166 9417972-5 1997 Acetylcholinesterase-positive fibers predominated in area TC and pyramidal neurons in areas TA and IA and in parts of TB; a mixture of fiber and neuronal staining was found in TC/TG, TD, and IB. Terbium 118-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 9417972-5 1997 Acetylcholinesterase-positive fibers predominated in area TC and pyramidal neurons in areas TA and IA and in parts of TB; a mixture of fiber and neuronal staining was found in TC/TG, TD, and IB. Technetium 58-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 9351648-1 1997 Analysis of 139 CSF samples from living subjects, using iso-electric focusing in polyacrylamide gels, demonstrated an anomalous molecular form of acetylcholinesterase (AChE). polyacrylamide 81-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-172 15989517-0 1997 Donepezil (E2020): a new acetylcholinesterase inhibitor. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 15989517-2 1997 Donepezil is an acetylcholinesterase inhibitor under development for the treatment of mild-moderately Alzheimer"s disease. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 15989517-3 1997 In vitro, donepezil is about 10 times more potent than tacrine as an inhibitor of acetylcholinesterase. Donepezil 10-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 15989517-3 1997 In vitro, donepezil is about 10 times more potent than tacrine as an inhibitor of acetylcholinesterase. Tacrine 55-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 15989517-4 1997 Donepezil is 500 - 1000 fold selective for acetylcholinesterase over butyrylcholinesterase. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 9367582-0 1997 Surface and Spectroscopic Properties of Acetylcholinesterase Monolayer at the Air/Water Interface The behavior of the enzyme acetylcholinesterase was studied at the air/water interface. Water 82-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 9367582-0 1997 Surface and Spectroscopic Properties of Acetylcholinesterase Monolayer at the Air/Water Interface The behavior of the enzyme acetylcholinesterase was studied at the air/water interface. Water 169-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 9367582-0 1997 Surface and Spectroscopic Properties of Acetylcholinesterase Monolayer at the Air/Water Interface The behavior of the enzyme acetylcholinesterase was studied at the air/water interface. Water 169-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 9367582-5 1997 The long-term stability of acetylcholinesterase at the air/water interface was demonstrated for pH 6.5 and a salt concentration of 10(-2) M (KCl). Water 59-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 9367582-5 1997 The long-term stability of acetylcholinesterase at the air/water interface was demonstrated for pH 6.5 and a salt concentration of 10(-2) M (KCl). Salts 109-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 9367582-5 1997 The long-term stability of acetylcholinesterase at the air/water interface was demonstrated for pH 6.5 and a salt concentration of 10(-2) M (KCl). Potassium Chloride 141-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 9325095-1 1997 Acetylcholinesterase (AChE), an enzyme involved in the hydrolysis of the neurotransmitter acetylcholine, consistently colocalizes with the amyloid deposits characteristic of Alzheimer"s disease and may contribute to the generation of amyloid proteins and/or physically affect fibril assembly. Acetylcholine 90-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 9428657-0 1997 Long chain analogs of physostigmine as potential drugs for Alzheimer"s disease: new insights into the mechanism of action in the inhibition of acetylcholinesterase. Physostigmine 22-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 9357518-0 1997 Novel tacrine analogues for potential use against Alzheimer"s disease: potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors. Tacrine 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 9357518-1 1997 Several novel analogues of tacrine have been synthesized and tested for their ability to inhibit acetylcholinesterase, butyrylcholinesterase, and neuronal uptake of 5-HT (serotonin) and noradrenaline. Tacrine 27-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 9325095-1 1997 Acetylcholinesterase (AChE), an enzyme involved in the hydrolysis of the neurotransmitter acetylcholine, consistently colocalizes with the amyloid deposits characteristic of Alzheimer"s disease and may contribute to the generation of amyloid proteins and/or physically affect fibril assembly. Acetylcholine 90-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 9325095-9 1997 AChE was seen to form strong complexes with the Abeta(12-28) fibrils as such complexes stained positively for both thioflavine-T and AChE activity, were resistant to high ionic strength treatment, and were partially sensitive to detergents, suggesting that hydrophobic interactions may play a role in the stabilization of the AChE-Abeta complex. thioflavin T 115-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 9301662-0 1997 Synthesis and study of thiocarbonate derivatives of choline as potential inhibitors of acetylcholinesterase. Carbonothioate 23-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 9301662-0 1997 Synthesis and study of thiocarbonate derivatives of choline as potential inhibitors of acetylcholinesterase. Choline 52-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 9301662-1 1997 Fourteen alkyl and aryl thiocarbonate derivatives of choline were synthesized and studied as potential inhibitors of acetylcholinesterase (AChE). alkyl and aryl thiocarbonate 9-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 9301662-1 1997 Fourteen alkyl and aryl thiocarbonate derivatives of choline were synthesized and studied as potential inhibitors of acetylcholinesterase (AChE). alkyl and aryl thiocarbonate 9-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 9301662-1 1997 Fourteen alkyl and aryl thiocarbonate derivatives of choline were synthesized and studied as potential inhibitors of acetylcholinesterase (AChE). Choline 53-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 9301662-1 1997 Fourteen alkyl and aryl thiocarbonate derivatives of choline were synthesized and studied as potential inhibitors of acetylcholinesterase (AChE). Choline 53-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 9278446-7 1997 A splice variant from the COLQ gene encodes a proline- rich AChE attachment domain without the collagen domain but does not represent the membrane anchor of the brain tetramer. Proline 46-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 9282941-0 1997 The amyloid beta-protein of Alzheimer"s disease increases acetylcholinesterase expression by increasing intracellular calcium in embryonal carcinoma P19 cells. Calcium 118-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 9282941-7 1997 To examine the possibility that the increase in AChE expression was mediated by an influx of calcium through voltage-dependent calcium channels (VDCCs), drugs acting on VDCCs were tested for their effects. Calcium 93-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 9282941-8 1997 Inhibitors of L-type VDCCs (diltiazem, nifedipine, and verapamil), but not N- or P- or Q-type VDCCs, resulted in a decrease in AChE expression. Diltiazem 28-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 9282941-8 1997 Inhibitors of L-type VDCCs (diltiazem, nifedipine, and verapamil), but not N- or P- or Q-type VDCCs, resulted in a decrease in AChE expression. Nifedipine 39-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 9282941-8 1997 Inhibitors of L-type VDCCs (diltiazem, nifedipine, and verapamil), but not N- or P- or Q-type VDCCs, resulted in a decrease in AChE expression. Verapamil 55-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 9282941-11 1997 Forskolin stimulated AChE expression, an action that was blocked by the L-type VDCC antagonist nifedipine. Colforsin 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 9282941-11 1997 Forskolin stimulated AChE expression, an action that was blocked by the L-type VDCC antagonist nifedipine. Nifedipine 95-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 9282941-12 1997 The A beta(25-35)induced increase in AChE expression was mediated by an L-type VDCC, as the effect was also blocked by nifedipine. Nifedipine 119-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 9282941-13 1997 The results suggest that the increase in AChE expression around amyloid plaques could be due to a disturbance in calcium homeostasis involving the opening of L-type VDCCs. Calcium 113-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 10322938-2 1997 METHODS: Using ELISA and enzyme inhibition test to examine the effect of 1-methyl-2-hydroxyiminomethylpyridium chloride (2-PAM), an anionic subsite probe of AChE, on the immunoreactivity between Torpedo AChE and its monoclonal antibody (McAb) 3F3. 1-methyl-2-hydroxyiminomethylpyridium chloride 73-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 203-207 9279214-7 1997 Physostigmine (0.1 mumol/L), an acetylcholinesterase inhibitor, reduced A23187-evoked histamine release by 58%. Physostigmine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 9279214-7 1997 Physostigmine (0.1 mumol/L), an acetylcholinesterase inhibitor, reduced A23187-evoked histamine release by 58%. Calcimycin 72-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 9279214-7 1997 Physostigmine (0.1 mumol/L), an acetylcholinesterase inhibitor, reduced A23187-evoked histamine release by 58%. Histamine 86-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 9292287-3 1997 2 Diethylphosphoryl-AChE resulting from intoxications with parathion, chlorpyrifos, chlorfenvinphos, diazinon and other OPs is characterized by slow spontaneous reactivation and low propensity for ageing. Parathion 59-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 9292287-3 1997 2 Diethylphosphoryl-AChE resulting from intoxications with parathion, chlorpyrifos, chlorfenvinphos, diazinon and other OPs is characterized by slow spontaneous reactivation and low propensity for ageing. Chlorpyrifos 70-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 9292287-3 1997 2 Diethylphosphoryl-AChE resulting from intoxications with parathion, chlorpyrifos, chlorfenvinphos, diazinon and other OPs is characterized by slow spontaneous reactivation and low propensity for ageing. Chlorfenvinphos 84-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 9292287-3 1997 2 Diethylphosphoryl-AChE resulting from intoxications with parathion, chlorpyrifos, chlorfenvinphos, diazinon and other OPs is characterized by slow spontaneous reactivation and low propensity for ageing. Diazinon 101-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 9292287-6 1997 Obidoxime turned out to be the most potent and most efficacious oxime in reactivating AChE inhibited by various classes of OP insecticides and tabun. Obidoxime Chloride 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 9292287-6 1997 Obidoxime turned out to be the most potent and most efficacious oxime in reactivating AChE inhibited by various classes of OP insecticides and tabun. Oximes 4-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 9292287-10 1997 However, in suicidal mega-dose poisoning, oximes, even at optimal plasma concentrations, may be unable to cope with the fast re-inhibition of reactivated AChE in the first days following intoxication. Oximes 42-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-158 9292288-3 1997 By virtue of in vitro findings and theoretical considerations we concluded in the preceding paper that oximes should preferably be administered by continuous infusion following an initial bolus dose for as long as reactivation of inhibited acetylcholinesterase (AChE) can be expected. Oximes 103-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 240-260 9292288-3 1997 By virtue of in vitro findings and theoretical considerations we concluded in the preceding paper that oximes should preferably be administered by continuous infusion following an initial bolus dose for as long as reactivation of inhibited acetylcholinesterase (AChE) can be expected. Oximes 103-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 262-266 9296387-10 1997 Moreover, a close correlation was observed between the fate of crosslinked proteins, including the TfR and acetylcholinesterase (AChE), and the fate of the clustered lipid N-Rh-PE. lissamine-rhodamine-phosphatidylethanolamine 172-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 9296387-10 1997 Moreover, a close correlation was observed between the fate of crosslinked proteins, including the TfR and acetylcholinesterase (AChE), and the fate of the clustered lipid N-Rh-PE. lissamine-rhodamine-phosphatidylethanolamine 172-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 9548205-2 1997 The first such drug to be launched in the U.K. was the acetylcholinesterase inhibitor, donepezil. Donepezil 87-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 9279814-9 1997 The desensitization of ACh receptors potentiated by proadifen, prevented completely the 6- to 8-fold prolongation of EPC which was induced by neostigmine inhibition of synaptic AChE. Proadifen 52-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-181 9279814-9 1997 The desensitization of ACh receptors potentiated by proadifen, prevented completely the 6- to 8-fold prolongation of EPC which was induced by neostigmine inhibition of synaptic AChE. Neostigmine 142-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-181 9239751-4 1997 However, cholinergic immunolesion resulted in significantly reduced alpha 2- and beta-adrenoceptor as well as 5-HT2A receptor binding in a number of cortical and hippocampal regions displaying a reduced activity of acetylcholinesterase, already detectable seven days after a single injection of 192IgG-saporin and persisting up to three months post lesion without any significant recovery. 192 IgG-saporin 295-309 acetylcholinesterase (Cartwright blood group) Homo sapiens 215-235 18966870-1 1997 A fibre-optic based on immobilized acetylcholinesterase is described and its application in the detection of carbamate and organophosphate pesticides through enzyme inhibition measurements is discussed. Carbamates 109-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 18966870-1 1997 A fibre-optic based on immobilized acetylcholinesterase is described and its application in the detection of carbamate and organophosphate pesticides through enzyme inhibition measurements is discussed. Organophosphates 123-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 18966870-2 1997 The bioactive component of the sensor consists of acetylcholinesterase covalently immobilized on preactivated isothiocyanate glass mixed with thymol blue indicator bound on aminopropyl glass and the sensor was constructed by packing a thin layer of the glass bead mixture at the tip of a bifurcated fibre-optic sensor head, which was then integrated with a flow-through cell. isothiocyanic acid 110-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 9224560-4 1997 In reverse micelles, some inhibitors of AChE (propidium, and d-tubocurarine) have much less effect upon indophenol-acetate hydrolysis than they do in a dilute solution environment. Acetates 115-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 9224629-1 1997 Asp-70 is the defining amino acid in the peripheral anionic site of human butyrylcholinesterase (BuChE), whereas acetylcholinesterase has several additional amino acids, the most important one being Trp-277 (Trp-279 in Torpedo AChE). Aspartic Acid 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 227-231 9268605-4 1997 Inhibition of AChE was greater than inhibition of NTE, without overlap of the concentration-response curves, for OPs which are more likely to cause acute, rather than delayed, neurotoxic effects in vivo (e.g., chlorpyrifos-oxon, dichlorvos, and trichlorfon). Trichlorfon 245-256 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 9269216-4 1997 METHODS: Positron emission tomography (PET) and a radiolabelled acetylcholine analogue with high hydrolytic specificity to acetylcholinesterase [11C]N-methyl-4-piperidyl acetate (MP4A), was used in eight elderly healthy controls and five patients with Alzheimer"s disease who had mild dementia. Acetylcholine 64-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-143 9269216-4 1997 METHODS: Positron emission tomography (PET) and a radiolabelled acetylcholine analogue with high hydrolytic specificity to acetylcholinesterase [11C]N-methyl-4-piperidyl acetate (MP4A), was used in eight elderly healthy controls and five patients with Alzheimer"s disease who had mild dementia. N-methyl-4-piperidyl acetate 149-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-143 9269216-4 1997 METHODS: Positron emission tomography (PET) and a radiolabelled acetylcholine analogue with high hydrolytic specificity to acetylcholinesterase [11C]N-methyl-4-piperidyl acetate (MP4A), was used in eight elderly healthy controls and five patients with Alzheimer"s disease who had mild dementia. mp4a 179-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-143 9224560-4 1997 In reverse micelles, some inhibitors of AChE (propidium, and d-tubocurarine) have much less effect upon indophenol-acetate hydrolysis than they do in a dilute solution environment. Propidium 46-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 9224560-4 1997 In reverse micelles, some inhibitors of AChE (propidium, and d-tubocurarine) have much less effect upon indophenol-acetate hydrolysis than they do in a dilute solution environment. Tubocurarine 61-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 9268605-0 1997 Acetylcholinesterase and neuropathy target esterase inhibitions in neuroblastoma cells to distinguish organophosphorus compounds causing acute and delayed neurotoxicity. Organophosphorus Compounds 102-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 9268605-1 1997 The differential inhibition of the target esterases acetylcholinesterase (AChE) and neuropathy target esterase (NTE, neurotoxic esterase) by organophosphorus compounds (OPs) is followed by distinct neurological consequences in exposed subjects. Organophosphorus Compounds 141-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 9268605-1 1997 The differential inhibition of the target esterases acetylcholinesterase (AChE) and neuropathy target esterase (NTE, neurotoxic esterase) by organophosphorus compounds (OPs) is followed by distinct neurological consequences in exposed subjects. Organophosphorus Compounds 141-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 9268605-4 1997 Inhibition of AChE was greater than inhibition of NTE, without overlap of the concentration-response curves, for OPs which are more likely to cause acute, rather than delayed, neurotoxic effects in vivo (e.g., chlorpyrifos-oxon, dichlorvos, and trichlorfon). O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 210-227 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 9268605-4 1997 Inhibition of AChE was greater than inhibition of NTE, without overlap of the concentration-response curves, for OPs which are more likely to cause acute, rather than delayed, neurotoxic effects in vivo (e.g., chlorpyrifos-oxon, dichlorvos, and trichlorfon). Dichlorvos 229-239 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 9224560-4 1997 In reverse micelles, some inhibitors of AChE (propidium, and d-tubocurarine) have much less effect upon indophenol-acetate hydrolysis than they do in a dilute solution environment. Indophenol 104-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 9187246-5 1997 Titration of active sites with an organophosphorous agent (MPT) revealed that the AChE of all venoms have similar turnovers (6000 to 8000 s(-1)) which are clearly higher than those of Torpedo and mammalian enzymes but lower than that of Electrophorus. organophosphorous 34-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 9192101-1 1997 The activity characteristics of membrane acetylcholinesterase from red blood cells of diabetic patients are very different from those of healthy donors: the limiting enzyme reaction rate is 17.2 +/- 0.8 mumol acetylthiocholine per ml packed cells per min compared with 13.1 +/- 0.8 mumol for control cells. Acetylthiocholine 209-226 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 9278940-0 1997 [Relationship between cholinergic symptoms caused by distigmine and the activities of serum AChE and BChE]. distigmine 53-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 9278940-3 1997 We evaluated the possibility of using serum acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) as specific clinical markers for the adverse cholinergic effects of distigmine. distigmine 173-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 9278940-4 1997 Of the twelve patients treated with distigmine for dysuria caused by psychotropic drugs six patients presented both adverse cholinergic effects and decreased levels of serum AChE and BChE. distigmine 36-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 9278940-6 1997 This study suggests that the values of serum AChE and BChE may be useful markers for the manifestation of adverse cholinergic effects caused by distigmine. distigmine 144-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 9187246-7 1997 SDS-PAGE analysis and sucrose gradient centrifugation demonstrated that AChE is exclusively present as a nonamphiphilic monomer. Sodium Dodecyl Sulfate 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 9187246-7 1997 SDS-PAGE analysis and sucrose gradient centrifugation demonstrated that AChE is exclusively present as a nonamphiphilic monomer. Sucrose 22-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 9175882-6 1997 Furthermore, in the case of 1,2-dimethylpropyl methylphosphono-HuAChE, the change in the molecular mass and the kinetics of non-reactivability appear to occur in parallel indicating that dealkylation is indeed the predominant molecular transformation leading to "aging" of phosphonyl-AChE adducts. 1,2-dimethylpropyl methylphosphono 28-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 9160669-5 1997 Differentiation induction with phorbol ester and exposure to recombinant human thrombopoietin suppressed both ACHEmRNA and AChE activity. Phorbol Esters 31-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 9169060-9 1997 AChE was also inhibited by trace amounts of oxon consistent with previously reported environmental levels. oxon 44-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 9161749-1 1997 PURPOSE: Acetylcholinesterase and butyrylcholinesterase are two closely related enzymes important in the metabolism of acetylcholine and anaesthetic drugs, including succinylcholine, mivacurium, and cocaine. Acetylcholine 119-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 9161749-1 1997 PURPOSE: Acetylcholinesterase and butyrylcholinesterase are two closely related enzymes important in the metabolism of acetylcholine and anaesthetic drugs, including succinylcholine, mivacurium, and cocaine. Succinylcholine 166-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 9161749-1 1997 PURPOSE: Acetylcholinesterase and butyrylcholinesterase are two closely related enzymes important in the metabolism of acetylcholine and anaesthetic drugs, including succinylcholine, mivacurium, and cocaine. Mivacurium 183-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 9161749-1 1997 PURPOSE: Acetylcholinesterase and butyrylcholinesterase are two closely related enzymes important in the metabolism of acetylcholine and anaesthetic drugs, including succinylcholine, mivacurium, and cocaine. Cocaine 199-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 9161749-2 1997 The solanaceous glycoalkaloids (SGAs) are naturally occurring steroids in potatoes and related plants that inhibit both acetylcholinesterase and butyrylcholinesterase. glycoalkaloids 16-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 9161749-2 1997 The solanaceous glycoalkaloids (SGAs) are naturally occurring steroids in potatoes and related plants that inhibit both acetylcholinesterase and butyrylcholinesterase. Steroids 62-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 9155262-0 1997 Singlet oxygen-mediated inactivation of acetylcholinesterase: a comparison of purified enzyme in solution and enzyme bound to K562 leukemia cells. Singlet Oxygen 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 9228650-2 1997 NIK-247, tacrine and E-2020 all strongly inhibited acetylcholinesterase (AChE) in human red blood cells (IC50s = 1.0 x 10(-6), 2.9 x 10(-7) and 3.7 x 10(-8) M, respectively). amiridine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 9228650-2 1997 NIK-247, tacrine and E-2020 all strongly inhibited acetylcholinesterase (AChE) in human red blood cells (IC50s = 1.0 x 10(-6), 2.9 x 10(-7) and 3.7 x 10(-8) M, respectively). amiridine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 9228650-2 1997 NIK-247, tacrine and E-2020 all strongly inhibited acetylcholinesterase (AChE) in human red blood cells (IC50s = 1.0 x 10(-6), 2.9 x 10(-7) and 3.7 x 10(-8) M, respectively). Tacrine 9-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 9228650-2 1997 NIK-247, tacrine and E-2020 all strongly inhibited acetylcholinesterase (AChE) in human red blood cells (IC50s = 1.0 x 10(-6), 2.9 x 10(-7) and 3.7 x 10(-8) M, respectively). Tacrine 9-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 9228650-2 1997 NIK-247, tacrine and E-2020 all strongly inhibited acetylcholinesterase (AChE) in human red blood cells (IC50s = 1.0 x 10(-6), 2.9 x 10(-7) and 3.7 x 10(-8) M, respectively). Donepezil 21-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 9228650-2 1997 NIK-247, tacrine and E-2020 all strongly inhibited acetylcholinesterase (AChE) in human red blood cells (IC50s = 1.0 x 10(-6), 2.9 x 10(-7) and 3.7 x 10(-8) M, respectively). Donepezil 21-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 9228650-5 1997 Moreover, the inhibitory effect of NIK-247 on AChE was reversible. amiridine 35-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 9155262-1 1997 We have compared the singlet oxygen-mediated inactivation of acetylcholinesterase (ACE) in solution with the inactivation of ACE on the surface of K562 leukemia cells. Singlet Oxygen 21-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 9155262-1 1997 We have compared the singlet oxygen-mediated inactivation of acetylcholinesterase (ACE) in solution with the inactivation of ACE on the surface of K562 leukemia cells. Singlet Oxygen 21-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-86 9169085-2 1997 Sarin-bound acetylcholinesterase (AChE) was solubilized from erythrocyte membranes of sarin victims, digested with trypsin, the sarin hydrolysis products bound to AChE were released by alkaline phosphatase digestion, and the digested sarin hydrolysis products were subjected to trimethylsilyl derivatization and detected by gas chromatography-mass spectrometry. Trimethylsilyl radical 278-292 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 9169085-2 1997 Sarin-bound acetylcholinesterase (AChE) was solubilized from erythrocyte membranes of sarin victims, digested with trypsin, the sarin hydrolysis products bound to AChE were released by alkaline phosphatase digestion, and the digested sarin hydrolysis products were subjected to trimethylsilyl derivatization and detected by gas chromatography-mass spectrometry. Trimethylsilyl radical 278-292 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 9155262-3 1997 The singlet oxygen quenchers, azide, Ni-chelate 1 and Ni-chelate 2, caused smaller inhibitions in the rate of singlet oxygen-mediated inactivation of ACE on K562 cells than ACE in solution. Singlet Oxygen 4-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-153 9155262-3 1997 The singlet oxygen quenchers, azide, Ni-chelate 1 and Ni-chelate 2, caused smaller inhibitions in the rate of singlet oxygen-mediated inactivation of ACE on K562 cells than ACE in solution. Singlet Oxygen 4-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-176 9155262-3 1997 The singlet oxygen quenchers, azide, Ni-chelate 1 and Ni-chelate 2, caused smaller inhibitions in the rate of singlet oxygen-mediated inactivation of ACE on K562 cells than ACE in solution. Azides 30-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-153 9155262-3 1997 The singlet oxygen quenchers, azide, Ni-chelate 1 and Ni-chelate 2, caused smaller inhibitions in the rate of singlet oxygen-mediated inactivation of ACE on K562 cells than ACE in solution. Azides 30-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-176 9155262-3 1997 The singlet oxygen quenchers, azide, Ni-chelate 1 and Ni-chelate 2, caused smaller inhibitions in the rate of singlet oxygen-mediated inactivation of ACE on K562 cells than ACE in solution. Singlet Oxygen 110-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-153 9155262-3 1997 The singlet oxygen quenchers, azide, Ni-chelate 1 and Ni-chelate 2, caused smaller inhibitions in the rate of singlet oxygen-mediated inactivation of ACE on K562 cells than ACE in solution. Singlet Oxygen 110-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-176 9155262-6 1997 The increases in ACE inactivation lifetime caused by the nickel chelates were anomalously large. Nickel 57-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-20 9070763-10 1997 When acetylcholinesterase was inhibited with a specific, membrane-impermeable inhibitor (1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide) which binds to its catalytic and peripheral anionic sites, the neurotrophic effect of hemolymph was significantly reduced. Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide 89-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-25 9109840-2 1997 The aim of the study was to ascertain the influence of the presence and activity of the autoimmune process involving a key enzyme (glutamic acid decarboxylase [GAD]) in the synthetic pathway of a neurotransmitter regulating somatostatin secretion, ie, gamma-aminobutyric acid (GABA), on the GH response to GHRH alone or combined with an acetylcholinesterase inhibitor, pyridostigmine (PD), in patients with type I diabetes mellitus. Aminobutyrates 258-275 acetylcholinesterase (Cartwright blood group) Homo sapiens 337-357 9109840-2 1997 The aim of the study was to ascertain the influence of the presence and activity of the autoimmune process involving a key enzyme (glutamic acid decarboxylase [GAD]) in the synthetic pathway of a neurotransmitter regulating somatostatin secretion, ie, gamma-aminobutyric acid (GABA), on the GH response to GHRH alone or combined with an acetylcholinesterase inhibitor, pyridostigmine (PD), in patients with type I diabetes mellitus. gamma-Aminobutyric Acid 277-281 acetylcholinesterase (Cartwright blood group) Homo sapiens 337-357 9109840-2 1997 The aim of the study was to ascertain the influence of the presence and activity of the autoimmune process involving a key enzyme (glutamic acid decarboxylase [GAD]) in the synthetic pathway of a neurotransmitter regulating somatostatin secretion, ie, gamma-aminobutyric acid (GABA), on the GH response to GHRH alone or combined with an acetylcholinesterase inhibitor, pyridostigmine (PD), in patients with type I diabetes mellitus. Pyridostigmine Bromide 369-383 acetylcholinesterase (Cartwright blood group) Homo sapiens 337-357 10072953-5 1997 The synthesized 24-peptide containing the active serine residue of the AChE active center did not react with McAb 3F3. Serine 49-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 9070763-14 1997 These results show that i) acetylcholinesterase circulating in the hemolymph promotes neurite growth of adult neurons in culture; ii) the growth promoting action of acetylcholinesterase is independent of its function of hydrolysing acetylcholine and iii) the peripheral anionic site of acetylcholinesterase appears to be involved in neurite regeneration. Acetylcholine 27-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-185 9070763-14 1997 These results show that i) acetylcholinesterase circulating in the hemolymph promotes neurite growth of adult neurons in culture; ii) the growth promoting action of acetylcholinesterase is independent of its function of hydrolysing acetylcholine and iii) the peripheral anionic site of acetylcholinesterase appears to be involved in neurite regeneration. Acetylcholine 27-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-185 9108896-1 1997 Donepezil is a specific and potent acetylcholinesterase inhibitor according to in vitro data. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 9085849-1 1997 In order to design ribozymes for the efficient cleavage of a human acetylcholinesterase (AChE) in vitro transcript, a completely randomized decadeoxyribonucleotide (dN10) was used in conjunction with RNase H to identify suitable sites for annealing. decadeoxyribonucleotide 140-163 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 9085849-1 1997 In order to design ribozymes for the efficient cleavage of a human acetylcholinesterase (AChE) in vitro transcript, a completely randomized decadeoxyribonucleotide (dN10) was used in conjunction with RNase H to identify suitable sites for annealing. decadeoxyribonucleotide 140-163 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 9108896-3 1997 In vivo, donepezil inhibited acetylcholinesterase activity in human erythrocytes and increased extracellular acetylcholine levels in the cerebral cortex and hippocampus of the rat. Donepezil 9-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 9212648-3 1997 This article suggests that the initial dural damage caused by trauma results in minor bleeding, which in turn causes a raised potassium ion concentration in the hemolytic fluid, which may also cause depolarization and elevated AChE in the dura. Potassium 126-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 227-231 8987799-5 1997 A second series of experiments demonstrated that mPRF microinjection of NLA significantly reduced the amount of REM sleep and the REM sleep-like state caused by mPRF injection of the acetylcholinesterase inhibitor neostigmine. Neostigmine 214-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-203 9073605-9 1997 In contrast to the L-enantiomers, the I50 plots of D-met-CS and D-norval-CS were not linear for BuChE, suggesting a possible stereospecific mechanistic shift for inhibition of this enzyme, AChE was not effectively inhibited by any of the CS compounds (I50 values > 750 microM). d-met-cs 51-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-193 9073605-9 1997 In contrast to the L-enantiomers, the I50 plots of D-met-CS and D-norval-CS were not linear for BuChE, suggesting a possible stereospecific mechanistic shift for inhibition of this enzyme, AChE was not effectively inhibited by any of the CS compounds (I50 values > 750 microM). d-norval-cs 64-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-193 9062656-2 1997 AChE inhibitors, including physostigmine, E-2020, amiridin, tetrahydroaminoacridine (THA) and Nicergoline had a poor effect on AChE present in the senile plaque-rich fraction isolated from Alzheimer brain than that either in the soluble fraction of Alzheimer brain or in the control brain. Physostigmine 27-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 9062656-2 1997 AChE inhibitors, including physostigmine, E-2020, amiridin, tetrahydroaminoacridine (THA) and Nicergoline had a poor effect on AChE present in the senile plaque-rich fraction isolated from Alzheimer brain than that either in the soluble fraction of Alzheimer brain or in the control brain. Donepezil 42-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 9062656-2 1997 AChE inhibitors, including physostigmine, E-2020, amiridin, tetrahydroaminoacridine (THA) and Nicergoline had a poor effect on AChE present in the senile plaque-rich fraction isolated from Alzheimer brain than that either in the soluble fraction of Alzheimer brain or in the control brain. amiridine 50-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 9062656-2 1997 AChE inhibitors, including physostigmine, E-2020, amiridin, tetrahydroaminoacridine (THA) and Nicergoline had a poor effect on AChE present in the senile plaque-rich fraction isolated from Alzheimer brain than that either in the soluble fraction of Alzheimer brain or in the control brain. Tacrine 60-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 9062656-2 1997 AChE inhibitors, including physostigmine, E-2020, amiridin, tetrahydroaminoacridine (THA) and Nicergoline had a poor effect on AChE present in the senile plaque-rich fraction isolated from Alzheimer brain than that either in the soluble fraction of Alzheimer brain or in the control brain. Tacrine 85-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 9062656-2 1997 AChE inhibitors, including physostigmine, E-2020, amiridin, tetrahydroaminoacridine (THA) and Nicergoline had a poor effect on AChE present in the senile plaque-rich fraction isolated from Alzheimer brain than that either in the soluble fraction of Alzheimer brain or in the control brain. Nicergoline 94-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 9089749-5 1997 Acetylcholine diffuses across the junctional cleft and binds to acetylcholinereceptors at the postjunctional part, and is thereafter metabolized by acetylcholinesterase in the junctional cleft. Acetylcholine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-168 9004460-1 1997 A kinetic analysis of the substitution of 6,6"-dithiodinicotinic acid (DTNA) for 5,5"-dithiobis-2-nitrobenzoic acid (DTNB) for the determination of rat and human erythrocyte acetylcholinesterase (AChE; EC 3.1.1.7) and plasma butyrylcholinesterase (BuChE; EC 3.1.1.8) is presented. 6,6'-dithiodinicotinic acid 71-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 196-200 9030907-4 1997 Acetylcholinesterase activity of adrenal homogenates was inhibited by tacrine and physostigmine in a concentration-dependent manner. Tacrine 70-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 9030907-4 1997 Acetylcholinesterase activity of adrenal homogenates was inhibited by tacrine and physostigmine in a concentration-dependent manner. Physostigmine 82-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 9049051-0 1997 Cooperative inhibition of acetylcholinesterase activities by hexachlorophene in human erythrocytes. Hexachlorophene 61-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 9049051-3 1997 The inhibition of AchE activities by HCP was reversed on adding albumin. Hexachlorophene 37-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 9049051-8 1997 On a Scatchard plot analysis, erythrocyte membranes appeared to have multiple binding sites of different affinities for HCP; binding of HCP to the low affinity site [dissociation constant (Kd) 4.7 x 10(-5) M] seemed to be responsible for the observed cooperative inhibition of AchE activities. Hexachlorophene 136-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 277-281 9049051-10 1997 HCP seems to be the most potent cooperative inhibitor of AchE in human erythrocyte membranes known to date. Hexachlorophene 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 9049051-11 1997 HCP may be useful to examine AchE and milieu in human erythrocyte membranes. Hexachlorophene 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 9209694-1 1997 The efficiency of newly synthesized oxime derivatives of quinuclidinium were tested in vitro on soman inhibited acetylcholinesterase (AChE) of human erythrocytes and in vivo using soman poisoned mice. Oximes 36-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 9209694-1 1997 The efficiency of newly synthesized oxime derivatives of quinuclidinium were tested in vitro on soman inhibited acetylcholinesterase (AChE) of human erythrocytes and in vivo using soman poisoned mice. Oximes 36-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 9209694-1 1997 The efficiency of newly synthesized oxime derivatives of quinuclidinium were tested in vitro on soman inhibited acetylcholinesterase (AChE) of human erythrocytes and in vivo using soman poisoned mice. quinuclidinium 57-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 9209694-1 1997 The efficiency of newly synthesized oxime derivatives of quinuclidinium were tested in vitro on soman inhibited acetylcholinesterase (AChE) of human erythrocytes and in vivo using soman poisoned mice. quinuclidinium 57-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 9471495-2 1997 Organophosphorus pesticides (OP) inhibit irreversibly acetylcholinesterase (AChE). organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 9365431-3 1997 She improved with a combination of benzodiazepines and the acetylcholinesterase inhibitor physostigmine. Physostigmine 90-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 9471495-2 1997 Organophosphorus pesticides (OP) inhibit irreversibly acetylcholinesterase (AChE). organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 9471495-3 1997 The known function of AChE is hydrolysis of the neurotransmitter, acetylcholine (ACh). Acetylcholine 66-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 9471495-5 1997 Since a long time it has been known, however, that in the nervous system the localization pattern of AChE does not overlap the localization of cholinergic neurons, and several recent findings show that apart from being the ACh hydrolyzing enzyme, AChE is also a neuromodulator participating in the phenomenon of neuronal plasticity i.e. induction of longterm changes in synaptic efficacy. Acetylcholine 101-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 247-251 8989325-0 1997 Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A. huperzine A 73-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-33 8978837-1 1996 The method of comparative molecular field analysis (CoMFA) was used to develop quantitative structure-activity relationships for physostigmine, 9-amino-1,2,3,4-tetrahydroacridine (THA), edrophonium (EDR), and other structurally diverse inhibitors of acetylcholinesterase (AChE). Tacrine 144-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 250-270 9471495-0 1997 [Possible consequences of AChE inhibition in organophosphate poisoning. Organophosphates 45-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 9029496-7 1997 In transgenic mice expressing human AChE, the hypothermic response to oxotremorine was suppressed, reflecting modified levels of brain muscarinic receptors. Oxotremorine 70-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 8988237-6 1996 In contrast to the meningioma species, brain G1A AChE forms remained amphiphilic after incubation with alkaline hydroxylamine and phosphatidylinositol-specific phospholipase C (PIPLC). alkaline hydroxylamine 103-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 8988237-6 1996 In contrast to the meningioma species, brain G1A AChE forms remained amphiphilic after incubation with alkaline hydroxylamine and phosphatidylinositol-specific phospholipase C (PIPLC). Phosphatidylinositols 130-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 8951045-0 1996 Inhibition of acetylcholinesterase by the neurotoxicant, 1-methyl-4-phenyl-2,3-dihydropyridinium ion. 1-methyl-4-phenyl-2,3-dihydropyridinium 57-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 8951045-1 1996 The effect of the neurotoxicant 1-methyl-4-phenyl-2,3-dihydropyridinium ion (MPDP+) on acetylcholinesterase (AchE) activity was investigated. 1-methyl-4-phenyl-2,3-dihydropyridinium 32-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 8951045-1 1996 The effect of the neurotoxicant 1-methyl-4-phenyl-2,3-dihydropyridinium ion (MPDP+) on acetylcholinesterase (AchE) activity was investigated. 1-methyl-4-phenyl-2,3-dihydropyridinium 32-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 8951045-1 1996 The effect of the neurotoxicant 1-methyl-4-phenyl-2,3-dihydropyridinium ion (MPDP+) on acetylcholinesterase (AchE) activity was investigated. 1-methyl-4-phenyl-2,3-dihydropyridinium 77-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 8951045-1 1996 The effect of the neurotoxicant 1-methyl-4-phenyl-2,3-dihydropyridinium ion (MPDP+) on acetylcholinesterase (AchE) activity was investigated. 1-methyl-4-phenyl-2,3-dihydropyridinium 77-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 8951045-3 1996 The kinetic parameter, Km, for the substrate acetylthiocholine was found to be 0.22 mM, and the Kis and Kii for MPDP+ inhibition of AChE were found to be 0.265 and 0.578 mM, respectively. Acetylthiocholine 45-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 8951045-3 1996 The kinetic parameter, Km, for the substrate acetylthiocholine was found to be 0.22 mM, and the Kis and Kii for MPDP+ inhibition of AChE were found to be 0.265 and 0.578 mM, respectively. 1-methyl-4-phenyl-2,3-dihydropyridinium 112-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 8951045-6 1996 The inhibition of AchE by MPDP+ was virtually reversed by either dilution or gel exclusion chromatography. 1-methyl-4-phenyl-2,3-dihydropyridinium 26-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 8951045-7 1996 These data suggest that once MPDP+ enters the basal ganglia of the brain, it can inhibit the AChE and thereby increase the acetylcholine level in the basal ganglia, leading to potential cell dysfunction. 1-methyl-4-phenyl-2,3-dihydropyridinium 29-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 8951045-8 1996 It appears likely that the nigrostriatal toxicity by MPDP+ leading to Parkinson"s disease-like syndrome may, at least in part, be mediated via the AChE inhibition. 1-methyl-4-phenyl-2,3-dihydropyridinium 53-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 9076564-5 1996 Based on our results and on the correlation reported in the literature between AChE reduction and muscarinic receptor density, the hazardous implications of organophosphate environmental contamination on human and animal health are pointed out. Organophosphates 157-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 8951236-0 1996 Synthesis and 31P chemical shift identification of tripeptide active site models that represent human serum acetylcholinesterase covalently modified at serine by certain organophosphates. tripeptide K-26 51-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 8951236-0 1996 Synthesis and 31P chemical shift identification of tripeptide active site models that represent human serum acetylcholinesterase covalently modified at serine by certain organophosphates. Serine 152-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 8951236-0 1996 Synthesis and 31P chemical shift identification of tripeptide active site models that represent human serum acetylcholinesterase covalently modified at serine by certain organophosphates. Organophosphates 170-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 8948485-1 1996 Acetylcholinesterase (AChE, EC 3.1.1.7) is an enzyme terminating the transmission of nerve impulse in synapses by rapid and selective hydrolysis of the neurotransmitter acetylcholine. Acetylcholine 169-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 8948485-1 1996 Acetylcholinesterase (AChE, EC 3.1.1.7) is an enzyme terminating the transmission of nerve impulse in synapses by rapid and selective hydrolysis of the neurotransmitter acetylcholine. Acetylcholine 169-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 8915035-9 1996 In addition, a statistically significant correlation between plasma concentrations of donepezil and AChE inhibition was demonstrated. Donepezil 86-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 9042248-0 1996 Characterization of human erythrocyte membrane-bound acetylcholinesterase inhibition by cisplatin at reversible phase. Cisplatin 88-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 9042248-1 1996 Acetylcholinesterase (AChE) is a perfect hydrolyzing enzyme, and it has been recently reported [Al-Jafari et al 1995; Kamal and Al-Jafari, 1996] that cisplatin, which is cytotoxic, has the ability to inhibit the AChE activity in vitro. Cisplatin 150-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 9042248-1 1996 Acetylcholinesterase (AChE) is a perfect hydrolyzing enzyme, and it has been recently reported [Al-Jafari et al 1995; Kamal and Al-Jafari, 1996] that cisplatin, which is cytotoxic, has the ability to inhibit the AChE activity in vitro. Cisplatin 150-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 9042248-1 1996 Acetylcholinesterase (AChE) is a perfect hydrolyzing enzyme, and it has been recently reported [Al-Jafari et al 1995; Kamal and Al-Jafari, 1996] that cisplatin, which is cytotoxic, has the ability to inhibit the AChE activity in vitro. Cisplatin 150-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 212-216 9042248-10 1996 This opens the possibilities for explaining the mechanism of AChE interaction with cisplatin as well as approaches towards understanding the causes of the neuro-type side effects of this drug. Cisplatin 83-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 9035375-1 1996 Some 6- and 7-methoxy-(and hydroxy-) tacrine derivatives were synthesized and evaluated for their in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities. 6- and 7-methoxy-(and hydroxy-) tacrine 5-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 9035375-2 1996 The most potent analogue in our series was the 9-heptylamino-6-methoxytacrine 3af which, in comparison with tacrine (THA), displayed an almost identical inhibitory effect, slightly lower acute toxicity and higher selectivity profile towards AchE when compared with THA. 9-heptylamino-6-methoxytacrine 47-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 241-245 9035375-2 1996 The most potent analogue in our series was the 9-heptylamino-6-methoxytacrine 3af which, in comparison with tacrine (THA), displayed an almost identical inhibitory effect, slightly lower acute toxicity and higher selectivity profile towards AchE when compared with THA. Tacrine 70-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 241-245 9076843-6 1996 In contrast, D/L sotalol reduced the maximal reaction velocity of the AChE isoenzyme from the central nervous system (caudate nucleus), but had no influence on substrate affinity of the enzyme (KM with ASCh unchanged) indicating purely non-competitive inhibition kinetics (rate constant of reversible non-competitive inhibition: Ki = 0.44 mM). Sotalol 17-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 9076843-7 1996 D/L-sotalol inhibition of erythrocyte AChE was of mixed competitive/non-competitive type (Ki = 0.31 mM, Ki = 0.49 mM). Sotalol 4-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 9076843-1 1996 Inhibitory effects of the class III antiarrhythmic compound D/L-sotalol on acetylcholinesterase (AChE; EC 3.1.1.7) isoenzymes of both erythrocytes and the human caudate nucleus and on serum cholinesterase (ChE; EC 3.1.1.8) were studied in vitro using a spectrophotometric kinetic assay with acetylthiocholine (ASCh) as substrate. Sotalol 64-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 9076843-8 1996 Non-competitive D/L-sotalol inhibition of caudate nucleus AChE and the non-competitive component of erythrocyte AChE inhibition cannot be overcome by increased concentrations of the cholinergic transmitter acetylcholine (ACh). Sotalol 20-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 8849682-1 1996 Conformational mobility of the surface omega loop (Cys-69-Cys-96) in human acetylcholinesterase (HuAChE) was recently implicated in substrate accessibility to the active center and in the mechanism of allosteric modulation of enzymatic activity. Cysteine 51-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 8849682-1 1996 Conformational mobility of the surface omega loop (Cys-69-Cys-96) in human acetylcholinesterase (HuAChE) was recently implicated in substrate accessibility to the active center and in the mechanism of allosteric modulation of enzymatic activity. Cysteine 58-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 8905144-3 1996 As a first step to establish the link between the CSS and improved neuronal function, we investigated if CSS alters the level of AChE activity in old Aplysia. thiocysteine 105-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 8905144-5 1996 Only in old animals did the CSS produce increased AChE activity levels in both the CNS and serum, and the increased levels were correlates of a change in the S/GWR, the behavior elicited by the CSS. thiocysteine 28-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 8899632-5 1996 Our unexpected finding was that with the AChE inhibitor present, adding 2 microM (-)-vesamicol decreases the size of the MEPCs by approximately 30%. vesamicol 81-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 8899632-11 1996 When AChE was inhibited, three treatments expected to block active choline (Ch) uptake into the presynaptic terminals decreased MEPC size: 1) elevating extracellular K+ to diminish the Na+ electrochemical gradient required for Ch uptake; 2) replacing extracellular Na+ with methylamine+; and 3) adding hemicholinium-3 (HC-3), an inhibitor of the Ch transporter. Choline 67-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 8899632-11 1996 When AChE was inhibited, three treatments expected to block active choline (Ch) uptake into the presynaptic terminals decreased MEPC size: 1) elevating extracellular K+ to diminish the Na+ electrochemical gradient required for Ch uptake; 2) replacing extracellular Na+ with methylamine+; and 3) adding hemicholinium-3 (HC-3), an inhibitor of the Ch transporter. methylamine 274-286 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 8899632-11 1996 When AChE was inhibited, three treatments expected to block active choline (Ch) uptake into the presynaptic terminals decreased MEPC size: 1) elevating extracellular K+ to diminish the Na+ electrochemical gradient required for Ch uptake; 2) replacing extracellular Na+ with methylamine+; and 3) adding hemicholinium-3 (HC-3), an inhibitor of the Ch transporter. Hemicholinium 3 302-317 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 8899632-11 1996 When AChE was inhibited, three treatments expected to block active choline (Ch) uptake into the presynaptic terminals decreased MEPC size: 1) elevating extracellular K+ to diminish the Na+ electrochemical gradient required for Ch uptake; 2) replacing extracellular Na+ with methylamine+; and 3) adding hemicholinium-3 (HC-3), an inhibitor of the Ch transporter. Hemicholinium 3 319-323 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 8836126-1 1996 We have examined the effects of 11 substitutions of active centre gorge residues of human acetylcholinesterase (HuAChE) on the rates of phosphonylation by 1,2,2-trimethylpropyl methyl-phosphonofluoridate (soman) and the aging of the resulting conjugates. Soman 155-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 8893840-2 1996 A new mode of binding of ACh to AChE was found which involves the carboxyl oxygen of ACh interacting with Gly 118 and 119. Acetylcholine 25-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 8893840-2 1996 A new mode of binding of ACh to AChE was found which involves the carboxyl oxygen of ACh interacting with Gly 118 and 119. Oxygen 75-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 8893840-2 1996 A new mode of binding of ACh to AChE was found which involves the carboxyl oxygen of ACh interacting with Gly 118 and 119. Glycine 106-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 8876775-0 1996 Double-blind, placebo-controlled study of metrifonate, an acetylcholinesterase inhibitor, for Alzheimer disease. Trichlorfon 42-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 8876775-2 1996 We dosed metrifonate to achieve a 40-60% inhibition of red blood cell acetylcholinesterase activity. Trichlorfon 9-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 9076843-8 1996 Non-competitive D/L-sotalol inhibition of caudate nucleus AChE and the non-competitive component of erythrocyte AChE inhibition cannot be overcome by increased concentrations of the cholinergic transmitter acetylcholine (ACh). Acetylcholine 206-219 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 9081295-0 1996 Synthesis of some new 2-methyl-4-(substituted benzylidene)1-phenyl-1,2,4 triazolo (3,4,-b) 1,4,5 thiadiazole as potential AChE inhibitory agents. 2-methyl-4-(substituted benzylidene)1-phenyl-1,2,4 triazolo (3,4,-b) 1,4,5 thiadiazole 22-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 8894101-3 1996 A combination of molecular modeling and QSAR studies have been used throughout the evolution of the AChE inhibitor program leading to the benzylpiperidine series, and, ultimately, E2020. 1-benzylpiperidine 138-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 8794905-0 1996 Interactions of oxime reactivators with diethylphosphoryl adducts of human acetylcholinesterase and its mutant derivatives. Oximes 16-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 8718893-0 1996 Aspartate 74 as a primary determinant in acetylcholinesterase governing specificity to cationic organophosphonates. Aspartic Acid 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 8761268-3 1996 "Synaptic" R-CMAPs, due to excess acetylcholine in the neuromuscular synapse, can occur in congenital myasthenia, the slow-channel syndrome, and acetylcholinesterase inhibition. Acetylcholine 34-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 8718877-1 1996 Acetylcholinesterase and butyrylcholinesterase both rapidly hydrolyze the neurotransmitter acetylcholine. Acetylcholine 91-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 8718877-2 1996 The unusual three-dimensional structure of acetylcholinesterase, in which the active site is located at the bottom of a deep and narrow gorge, raises cogent questions concerning traffic of the substrate, acetylcholine, and the products, choline and acetate, to and from the active site. Acetates 249-256 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 8718877-7 1996 Photolysis both of acetylcholinesterase and of butyrylcholinesterase, complexed with a 2-nitrobenzyl derivative of choline, resulted in regeneration of enzymic activity. 2-nitrobenzyl 87-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 8718877-8 1996 Photolysis of acetylcholinesterase complexed with the 2-nitrobenzyl derivative of carbamylcholine led to time-dependent inactivation, resulting from carbamylation of acetylcholinesterase, which could be reversed upon dilution, due to decarbamylation. 2-nitrobenzyl 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 8718877-8 1996 Photolysis of acetylcholinesterase complexed with the 2-nitrobenzyl derivative of carbamylcholine led to time-dependent inactivation, resulting from carbamylation of acetylcholinesterase, which could be reversed upon dilution, due to decarbamylation. 2-nitrobenzyl 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-186 8928167-2 1996 The authors describe the rationale for use of the acetylcholinesterase inhibitor, tacrine, in Alzheimer"s disease and critically review the controlled clinical trials using this drug. Tacrine 82-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 8718893-7 1996 Docking of Sp and Rp cycloheptyl methylphosphonyl thiocholines and thioethylates in AChE as models of the reversible complex and transition state using molecular dynamics affords structural insight into the spatial arrangement of the substituents surrounding phosphorus prior to and during reaction. Phosphorus 259-269 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 8806451-9 1996 DbcAMP increased the activity of acetylcholinesterase (AChE) up to 10-fold compared to untreated cells, while butyrate had a substantially lesser effect. Bucladesine 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 8806451-9 1996 DbcAMP increased the activity of acetylcholinesterase (AChE) up to 10-fold compared to untreated cells, while butyrate had a substantially lesser effect. Bucladesine 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 8823240-14 1996 In the eptastigmine group, performances on all tests and scales improved with an inverted U-shaped relation to average daily acetylcholinesterase inhibition. physostigmine heptyl 7-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 8823240-15 1996 CONCLUSIONS: This study shows that doses of 40 to 60 mg per day of eptastigmine are relatively safe and well tolerated and that moderate acetylcholinesterase inhibition is associated with maximal cognitive efficacy. physostigmine heptyl 67-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 8844403-8 1996 Treatment of myoblasts induced to differentiate with chlorate resulted in an inhibition of cell fusion and AChE activity. Chlorates 53-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 8764619-2 1996 The study was carried out in eight healthy human volunteers using as a tracer [11C]-physostigmine ([11C]PHY), an inhibitor of AChE. Carbon-11 79-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 8764619-2 1996 The study was carried out in eight healthy human volunteers using as a tracer [11C]-physostigmine ([11C]PHY), an inhibitor of AChE. Physostigmine 84-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 8764619-2 1996 The study was carried out in eight healthy human volunteers using as a tracer [11C]-physostigmine ([11C]PHY), an inhibitor of AChE. Carbon-11 100-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 8764619-5 1996 [11C] PHY retention was higher in regions rich in AChE, such as the striatum (half-life, 35 min), than in regions poor in AChE, such as the cerebral cortex (half-life, 20 min). Carbon-11 1-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 8764619-6 1996 At later times (25-35 min postinjection), the cerebral distribution of [11C]PHY was typical of AChE activity: putamen-caudate > cerebellum > brainstem > thalamus > cerebral cortex, with a striatal to cortex ratio of 2. Carbon-11 72-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 8764619-7 1996 These results suggest that PET studies with [11C]PHY can provide in vivo brain mapping of human AChE and are promising for the study of changes in AChE levels associated with neurodegenerative diseases. Carbon-11 45-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 8764619-7 1996 These results suggest that PET studies with [11C]PHY can provide in vivo brain mapping of human AChE and are promising for the study of changes in AChE levels associated with neurodegenerative diseases. Carbon-11 45-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 8899566-1 1996 We have previously reported that dorsal root ganglion neurons cultured in the presence of the highly specific, reversible acetylcholinesterase inhibitor 1,5-bis-(4-allyldimethylammoniumphenyl) pentan-3-one dibromide (BW284c51), showed significantly reduced neurite outgrowth and contained massive perikaryal inclusions of neurofilaments. 1,5-bis-(4-allyldimethylammoniumphenyl) pentan-3-one dibromide 153-215 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 8899566-1 1996 We have previously reported that dorsal root ganglion neurons cultured in the presence of the highly specific, reversible acetylcholinesterase inhibitor 1,5-bis-(4-allyldimethylammoniumphenyl) pentan-3-one dibromide (BW284c51), showed significantly reduced neurite outgrowth and contained massive perikaryal inclusions of neurofilaments. Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide 217-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 8899566-9 1996 Treatment with dbcAMP also increased acetylcholinesterase activity which has been positively correlated with neurite outgrowth both in vivo and in vitro. Bucladesine 15-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 8899663-0 1996 Glycine effects on glutamate-receptor elicited acetylcholinesterase release from slices and synaptosomes of the spinal ventral horn. Glycine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 8899663-2 1996 Glutamate (GLU), kainate and AMPA, as well as glycine (GLY) evoked dose-related, calcium-dependent liberation of soluble forms of AChE from both slices and synaptosomes. Glutamic Acid 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 8899663-2 1996 Glutamate (GLU), kainate and AMPA, as well as glycine (GLY) evoked dose-related, calcium-dependent liberation of soluble forms of AChE from both slices and synaptosomes. Glutamic Acid 11-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 8899663-2 1996 Glutamate (GLU), kainate and AMPA, as well as glycine (GLY) evoked dose-related, calcium-dependent liberation of soluble forms of AChE from both slices and synaptosomes. Kainic Acid 17-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 8899663-2 1996 Glutamate (GLU), kainate and AMPA, as well as glycine (GLY) evoked dose-related, calcium-dependent liberation of soluble forms of AChE from both slices and synaptosomes. Glycine 46-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 8899663-2 1996 Glutamate (GLU), kainate and AMPA, as well as glycine (GLY) evoked dose-related, calcium-dependent liberation of soluble forms of AChE from both slices and synaptosomes. Glycine 55-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 8899663-2 1996 Glutamate (GLU), kainate and AMPA, as well as glycine (GLY) evoked dose-related, calcium-dependent liberation of soluble forms of AChE from both slices and synaptosomes. Calcium 81-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 8899663-3 1996 GLY-evoked AChE release showed remarkable age-related postnatal changes. Glycine 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-15 8899663-5 1996 GLY potentiated the GEAR response in the presence of strychnine, suggesting N-methyl-D-aspartate (NMDA) receptor involvement, and was also able to evoke a strychnine-sensitive AChE release in the absence of exogenous GLU. Glycine 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 8899663-5 1996 GLY potentiated the GEAR response in the presence of strychnine, suggesting N-methyl-D-aspartate (NMDA) receptor involvement, and was also able to evoke a strychnine-sensitive AChE release in the absence of exogenous GLU. Strychnine 155-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 8899663-6 1996 After the 28th postnatal day, nearly all the AChE secreted was released either after the activation of non-NMDA glutamate receptors or by strychnine-sensitive GLY-evoked AChE release mechanisms. Strychnine 138-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 8899663-6 1996 After the 28th postnatal day, nearly all the AChE secreted was released either after the activation of non-NMDA glutamate receptors or by strychnine-sensitive GLY-evoked AChE release mechanisms. Strychnine 138-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 8899663-6 1996 After the 28th postnatal day, nearly all the AChE secreted was released either after the activation of non-NMDA glutamate receptors or by strychnine-sensitive GLY-evoked AChE release mechanisms. Glycine 159-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 8899663-6 1996 After the 28th postnatal day, nearly all the AChE secreted was released either after the activation of non-NMDA glutamate receptors or by strychnine-sensitive GLY-evoked AChE release mechanisms. Glycine 159-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 8899663-7 1996 Both GEAR and GLY-evoked AChE release might impair the negative feedback loop which modulates the overactivation of motor neurones, and cause prolonged extracellular rises of soluble AChE. Glycine 14-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 8899663-7 1996 Both GEAR and GLY-evoked AChE release might impair the negative feedback loop which modulates the overactivation of motor neurones, and cause prolonged extracellular rises of soluble AChE. Glycine 14-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-187 8806851-1 1996 The cholinergic toxicity of malathion is exacerbated by its isomerization product, isomalathion, which inhibits detoxifying carboxylesterases as well as target acetylcholinesterase (AChE). Malathion 28-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-180 8806851-1 1996 The cholinergic toxicity of malathion is exacerbated by its isomerization product, isomalathion, which inhibits detoxifying carboxylesterases as well as target acetylcholinesterase (AChE). Malathion 28-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-186 8718877-8 1996 Photolysis of acetylcholinesterase complexed with the 2-nitrobenzyl derivative of carbamylcholine led to time-dependent inactivation, resulting from carbamylation of acetylcholinesterase, which could be reversed upon dilution, due to decarbamylation. Carbachol 82-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 8718877-8 1996 Photolysis of acetylcholinesterase complexed with the 2-nitrobenzyl derivative of carbamylcholine led to time-dependent inactivation, resulting from carbamylation of acetylcholinesterase, which could be reversed upon dilution, due to decarbamylation. Carbachol 82-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-186 8718877-11 1996 In the latter case, choline was generated enzymatically, within the active site, concomitantly with carbamylation of the acetylcholinesterase. Choline 20-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 8981558-1 1996 Inhibitory effects of the dopamine D2-receptor antagonistic benzamide compound metoclopramide (MCP) on acetylcholinesterase (AChE; EC 3.1.1.7) isoenzymes of both erythrocytes and human caudate nucleus and on human serum cholinesterase (ChE; EC 3.1.1.8) were studied in vitro using a spectrophotometric assay with acetylthiocholine (ASCh) as substrate. benzamide 60-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 8718893-0 1996 Aspartate 74 as a primary determinant in acetylcholinesterase governing specificity to cationic organophosphonates. Organophosphonates 96-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 8981558-1 1996 Inhibitory effects of the dopamine D2-receptor antagonistic benzamide compound metoclopramide (MCP) on acetylcholinesterase (AChE; EC 3.1.1.7) isoenzymes of both erythrocytes and human caudate nucleus and on human serum cholinesterase (ChE; EC 3.1.1.8) were studied in vitro using a spectrophotometric assay with acetylthiocholine (ASCh) as substrate. benzamide 60-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 8981558-1 1996 Inhibitory effects of the dopamine D2-receptor antagonistic benzamide compound metoclopramide (MCP) on acetylcholinesterase (AChE; EC 3.1.1.7) isoenzymes of both erythrocytes and human caudate nucleus and on human serum cholinesterase (ChE; EC 3.1.1.8) were studied in vitro using a spectrophotometric assay with acetylthiocholine (ASCh) as substrate. Metoclopramide 79-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 8981558-1 1996 Inhibitory effects of the dopamine D2-receptor antagonistic benzamide compound metoclopramide (MCP) on acetylcholinesterase (AChE; EC 3.1.1.7) isoenzymes of both erythrocytes and human caudate nucleus and on human serum cholinesterase (ChE; EC 3.1.1.8) were studied in vitro using a spectrophotometric assay with acetylthiocholine (ASCh) as substrate. Metoclopramide 79-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 8981558-1 1996 Inhibitory effects of the dopamine D2-receptor antagonistic benzamide compound metoclopramide (MCP) on acetylcholinesterase (AChE; EC 3.1.1.7) isoenzymes of both erythrocytes and human caudate nucleus and on human serum cholinesterase (ChE; EC 3.1.1.8) were studied in vitro using a spectrophotometric assay with acetylthiocholine (ASCh) as substrate. Metoclopramide 95-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 8981558-1 1996 Inhibitory effects of the dopamine D2-receptor antagonistic benzamide compound metoclopramide (MCP) on acetylcholinesterase (AChE; EC 3.1.1.7) isoenzymes of both erythrocytes and human caudate nucleus and on human serum cholinesterase (ChE; EC 3.1.1.8) were studied in vitro using a spectrophotometric assay with acetylthiocholine (ASCh) as substrate. Metoclopramide 95-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 8718893-1 1996 Through site-specific mutagenesis, we examined the determinants on acetylcholinesterase which govern the specificity and reactivity of three classes of substrates: enantiomeric alkyl phosphonates, trifluoromethyl acetophenones, and carboxyl esters. alkyl phosphonates 177-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 8718893-1 1996 Through site-specific mutagenesis, we examined the determinants on acetylcholinesterase which govern the specificity and reactivity of three classes of substrates: enantiomeric alkyl phosphonates, trifluoromethyl acetophenones, and carboxyl esters. trifluoromethyl acetophenones 197-226 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 8718893-1 1996 Through site-specific mutagenesis, we examined the determinants on acetylcholinesterase which govern the specificity and reactivity of three classes of substrates: enantiomeric alkyl phosphonates, trifluoromethyl acetophenones, and carboxyl esters. carboxyl esters 232-247 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 8984476-0 1996 [Purification of acetylcholinesterase from human erythrocytes using metal-chelate affinity chromatography]. Metals 68-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 8718893-7 1996 Docking of Sp and Rp cycloheptyl methylphosphonyl thiocholines and thioethylates in AChE as models of the reversible complex and transition state using molecular dynamics affords structural insight into the spatial arrangement of the substituents surrounding phosphorus prior to and during reaction. TFF2 protein, human 11-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 8984476-1 1996 Acetylcholinesterase (AChE) was purified on columns with iminodiacetate Agarose charged with Cu2+, Zn2+, and Ni2+. iminodiacetic acid 57-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 8718893-7 1996 Docking of Sp and Rp cycloheptyl methylphosphonyl thiocholines and thioethylates in AChE as models of the reversible complex and transition state using molecular dynamics affords structural insight into the spatial arrangement of the substituents surrounding phosphorus prior to and during reaction. cycloheptyl methylphosphonyl thiocholines 21-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 8984476-1 1996 Acetylcholinesterase (AChE) was purified on columns with iminodiacetate Agarose charged with Cu2+, Zn2+, and Ni2+. iminodiacetic acid 57-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 8718893-7 1996 Docking of Sp and Rp cycloheptyl methylphosphonyl thiocholines and thioethylates in AChE as models of the reversible complex and transition state using molecular dynamics affords structural insight into the spatial arrangement of the substituents surrounding phosphorus prior to and during reaction. thioethylates 67-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 8984476-1 1996 Acetylcholinesterase (AChE) was purified on columns with iminodiacetate Agarose charged with Cu2+, Zn2+, and Ni2+. Sepharose 72-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 8984476-1 1996 Acetylcholinesterase (AChE) was purified on columns with iminodiacetate Agarose charged with Cu2+, Zn2+, and Ni2+. Sepharose 72-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 8984476-1 1996 Acetylcholinesterase (AChE) was purified on columns with iminodiacetate Agarose charged with Cu2+, Zn2+, and Ni2+. Zinc 99-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 8984476-1 1996 Acetylcholinesterase (AChE) was purified on columns with iminodiacetate Agarose charged with Cu2+, Zn2+, and Ni2+. cupric ion 93-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 8984476-1 1996 Acetylcholinesterase (AChE) was purified on columns with iminodiacetate Agarose charged with Cu2+, Zn2+, and Ni2+. cupric ion 93-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 8984476-1 1996 Acetylcholinesterase (AChE) was purified on columns with iminodiacetate Agarose charged with Cu2+, Zn2+, and Ni2+. Nickel(2+) 109-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 8984476-1 1996 Acetylcholinesterase (AChE) was purified on columns with iminodiacetate Agarose charged with Cu2+, Zn2+, and Ni2+. Zinc 99-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 8984476-1 1996 Acetylcholinesterase (AChE) was purified on columns with iminodiacetate Agarose charged with Cu2+, Zn2+, and Ni2+. Nickel(2+) 109-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 9054171-1 1996 The antienzymic activities of 14 organophosphorous compounds, the derivatives of dialkyl thiophosphoric acid, towards the acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and carboxylesterase (CE) from the spring grain aphid and mammals were investigated. organophosphorous 33-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 9000302-2 1996 AntiChEs consist of the organophosphates (OP), which irreversibly inhibit the enzyme acetylcholinesterase (AChE), and the carbamates (CB), which reversibly inhibit AChE. Organophosphates 24-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 9000302-2 1996 AntiChEs consist of the organophosphates (OP), which irreversibly inhibit the enzyme acetylcholinesterase (AChE), and the carbamates (CB), which reversibly inhibit AChE. Organophosphates 24-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 9000302-2 1996 AntiChEs consist of the organophosphates (OP), which irreversibly inhibit the enzyme acetylcholinesterase (AChE), and the carbamates (CB), which reversibly inhibit AChE. Carbamates 122-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 9054171-1 1996 The antienzymic activities of 14 organophosphorous compounds, the derivatives of dialkyl thiophosphoric acid, towards the acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and carboxylesterase (CE) from the spring grain aphid and mammals were investigated. dialkyl thiophosphoric acid 81-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 9054171-2 1996 The dependence of inhibitory activity of the compounds on their alkyl radical length was shown to be different for the AchE from the aphid and man. alkyl radical 64-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 8813709-0 1996 In vitro inhibition of human erythrocyte acetylcholinesterase (EC3.1.1.7) by an antineoplastic drug methotrexate. Methotrexate 100-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 8813709-1 1996 This work addresses the kinetic analysis of the interaction of methotrexate (MTX) with human erythrocyte membrane-bound acetylcholinesterase (AChE, EC 3.1.1.7). Methotrexate 63-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 8813709-1 1996 This work addresses the kinetic analysis of the interaction of methotrexate (MTX) with human erythrocyte membrane-bound acetylcholinesterase (AChE, EC 3.1.1.7). Methotrexate 63-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 24203318-0 1996 Testosterone levels among Ache hunter-gatherer men : A functional interpretation of population variation among adult males. Testosterone 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 24203318-9 1996 Comparison of Ache values with those for other populations confirms the prevalence of significant interpopulational variation in testosterone levels among adult males. Testosterone 129-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 8783106-5 1996 The number of AChE-positive nerve fibers was markedly increased in the IAS of patients with HSCR, IND, and IAS achalasia compared with controls. indole 98-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 8817817-4 1996 Modification of three aromatic amino acids in the peripheral site of AChE, the binding site for fasciculin, decreased the affinity 100 to one million times. Amino Acids, Aromatic 22-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 8813367-3 1996 Marked enhancement of AChE staining was noticed in the CA1 of saline-treated animals at 100 days after ischemia, while the post-ischemic enhancement of AChE staining intensity was milder in BF-treated animals. Sodium Chloride 62-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 8813367-3 1996 Marked enhancement of AChE staining was noticed in the CA1 of saline-treated animals at 100 days after ischemia, while the post-ischemic enhancement of AChE staining intensity was milder in BF-treated animals. bifemelane 190-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 8813367-3 1996 Marked enhancement of AChE staining was noticed in the CA1 of saline-treated animals at 100 days after ischemia, while the post-ischemic enhancement of AChE staining intensity was milder in BF-treated animals. bifemelane 190-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 8762162-3 1996 The siphon/gill withdrawal reflex (S/GWR) and gill pumping movement (GPM) were examined to assay the effects of AChE inhibition by BW284c51, a specific and reversible AChE inhibitor. Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide 131-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 8762162-5 1996 In old animals, AChE inhibition by 2 microM of BW284c51 did not affect S/GWR and only dishabituation was suppressed by inhibition by 5 microM of BW284c51. Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide 47-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 8762162-9 1996 Comparisons of the results of AChE inhibition which would elevate acetylcholine (ACh) levels with those of carbachol administration revealed that AChE inhibition affects both cholinergic and non-cholinergic mechanisms underlying the two behaviors. Acetylcholine 66-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 8762162-9 1996 Comparisons of the results of AChE inhibition which would elevate acetylcholine (ACh) levels with those of carbachol administration revealed that AChE inhibition affects both cholinergic and non-cholinergic mechanisms underlying the two behaviors. Acetylcholine 66-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 8762162-9 1996 Comparisons of the results of AChE inhibition which would elevate acetylcholine (ACh) levels with those of carbachol administration revealed that AChE inhibition affects both cholinergic and non-cholinergic mechanisms underlying the two behaviors. Acetylcholine 30-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 8762162-9 1996 Comparisons of the results of AChE inhibition which would elevate acetylcholine (ACh) levels with those of carbachol administration revealed that AChE inhibition affects both cholinergic and non-cholinergic mechanisms underlying the two behaviors. Carbachol 107-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 8799456-0 1996 Investigation of the effect of anti-neoplastic drugs, cyclophosphamide, cisplatin and methotrexate on the turnover kinetics of human erythrocyte acetylcholinesterase. Cisplatin 72-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 8799456-0 1996 Investigation of the effect of anti-neoplastic drugs, cyclophosphamide, cisplatin and methotrexate on the turnover kinetics of human erythrocyte acetylcholinesterase. Methotrexate 86-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 8799456-1 1996 The present work addresses the effects of three antineoplastic drugs [cyclophosphamide (CP), cisplatin (CDDP) and methotrexate (MTX) which are in current use for the treatment of various tumors] on turnover kinetics of human erythrocyte membrane-bound acetylcholinesterase (AcChoEase, EC 3.1.1.7). Cyclophosphamide 70-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 252-272 8799456-1 1996 The present work addresses the effects of three antineoplastic drugs [cyclophosphamide (CP), cisplatin (CDDP) and methotrexate (MTX) which are in current use for the treatment of various tumors] on turnover kinetics of human erythrocyte membrane-bound acetylcholinesterase (AcChoEase, EC 3.1.1.7). Cyclophosphamide 70-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 274-283 8799456-1 1996 The present work addresses the effects of three antineoplastic drugs [cyclophosphamide (CP), cisplatin (CDDP) and methotrexate (MTX) which are in current use for the treatment of various tumors] on turnover kinetics of human erythrocyte membrane-bound acetylcholinesterase (AcChoEase, EC 3.1.1.7). Cisplatin 93-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 252-272 8799456-1 1996 The present work addresses the effects of three antineoplastic drugs [cyclophosphamide (CP), cisplatin (CDDP) and methotrexate (MTX) which are in current use for the treatment of various tumors] on turnover kinetics of human erythrocyte membrane-bound acetylcholinesterase (AcChoEase, EC 3.1.1.7). Cisplatin 93-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 274-283 8799456-1 1996 The present work addresses the effects of three antineoplastic drugs [cyclophosphamide (CP), cisplatin (CDDP) and methotrexate (MTX) which are in current use for the treatment of various tumors] on turnover kinetics of human erythrocyte membrane-bound acetylcholinesterase (AcChoEase, EC 3.1.1.7). Methotrexate 114-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 252-272 8799456-1 1996 The present work addresses the effects of three antineoplastic drugs [cyclophosphamide (CP), cisplatin (CDDP) and methotrexate (MTX) which are in current use for the treatment of various tumors] on turnover kinetics of human erythrocyte membrane-bound acetylcholinesterase (AcChoEase, EC 3.1.1.7). Methotrexate 114-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 274-283 8799456-1 1996 The present work addresses the effects of three antineoplastic drugs [cyclophosphamide (CP), cisplatin (CDDP) and methotrexate (MTX) which are in current use for the treatment of various tumors] on turnover kinetics of human erythrocyte membrane-bound acetylcholinesterase (AcChoEase, EC 3.1.1.7). Methotrexate 128-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 252-272 8799456-1 1996 The present work addresses the effects of three antineoplastic drugs [cyclophosphamide (CP), cisplatin (CDDP) and methotrexate (MTX) which are in current use for the treatment of various tumors] on turnover kinetics of human erythrocyte membrane-bound acetylcholinesterase (AcChoEase, EC 3.1.1.7). Methotrexate 128-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 274-283 8818729-6 1996 The reason why some species of gastrointestinal nematodes resistant to benzimidazoles contain elevated amounts of acetylcholinesterase is unclear. Benzimidazoles 71-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 8813709-1 1996 This work addresses the kinetic analysis of the interaction of methotrexate (MTX) with human erythrocyte membrane-bound acetylcholinesterase (AChE, EC 3.1.1.7). Methotrexate 77-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 8813709-1 1996 This work addresses the kinetic analysis of the interaction of methotrexate (MTX) with human erythrocyte membrane-bound acetylcholinesterase (AChE, EC 3.1.1.7). Methotrexate 77-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 8813709-2 1996 It was found that the MTX effect was independent of time of incubation with AChE before the addition of substrate which proves its reversible action. Methotrexate 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 8813709-4 1996 The Michaelis-Menten constant (Ks) for the hydrolysis of acetylthiocholine iodide (ASCh) by AChE was 0.13 mM in the control system, a value decreased by 30-61% in the MTX treated systems. Potassium 31-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 8813709-4 1996 The Michaelis-Menten constant (Ks) for the hydrolysis of acetylthiocholine iodide (ASCh) by AChE was 0.13 mM in the control system, a value decreased by 30-61% in the MTX treated systems. acetylthiocholine iodide 57-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 8792327-2 1996 Acetylcholinesterase (AChE) is distinguished from butyrylcholinesterase (BChE) by its greater specificity for hydrolysing acetylcholine. Acetylcholine 122-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 8813709-4 1996 The Michaelis-Menten constant (Ks) for the hydrolysis of acetylthiocholine iodide (ASCh) by AChE was 0.13 mM in the control system, a value decreased by 30-61% in the MTX treated systems. asch 83-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 8813709-4 1996 The Michaelis-Menten constant (Ks) for the hydrolysis of acetylthiocholine iodide (ASCh) by AChE was 0.13 mM in the control system, a value decreased by 30-61% in the MTX treated systems. Methotrexate 167-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 8638849-11 1996 RESULTS: Acetylcholinesterase was a poor hydrolyzer of mivacurium, as bioassayed by reversal of paralysis. Mivacurium 55-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 8784921-1 1996 A method for preparing various forms of acetylcholinesterase (AChE) from human erythrocyte has been established and they have been characterized in terms of kinetic parameters such as K(m), rate constant (k), turnover number (kcat), specificity constant (ksp), Vmax, half-life (t1/2), IC50 and Ki for tetrabutylammonium hydroxide, procaine and physostigmine in the present study. tetrabutylammonium 301-329 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 8784921-1 1996 A method for preparing various forms of acetylcholinesterase (AChE) from human erythrocyte has been established and they have been characterized in terms of kinetic parameters such as K(m), rate constant (k), turnover number (kcat), specificity constant (ksp), Vmax, half-life (t1/2), IC50 and Ki for tetrabutylammonium hydroxide, procaine and physostigmine in the present study. tetrabutylammonium 301-329 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 8784921-1 1996 A method for preparing various forms of acetylcholinesterase (AChE) from human erythrocyte has been established and they have been characterized in terms of kinetic parameters such as K(m), rate constant (k), turnover number (kcat), specificity constant (ksp), Vmax, half-life (t1/2), IC50 and Ki for tetrabutylammonium hydroxide, procaine and physostigmine in the present study. Procaine 331-339 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 8784921-1 1996 A method for preparing various forms of acetylcholinesterase (AChE) from human erythrocyte has been established and they have been characterized in terms of kinetic parameters such as K(m), rate constant (k), turnover number (kcat), specificity constant (ksp), Vmax, half-life (t1/2), IC50 and Ki for tetrabutylammonium hydroxide, procaine and physostigmine in the present study. Procaine 331-339 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 8784921-1 1996 A method for preparing various forms of acetylcholinesterase (AChE) from human erythrocyte has been established and they have been characterized in terms of kinetic parameters such as K(m), rate constant (k), turnover number (kcat), specificity constant (ksp), Vmax, half-life (t1/2), IC50 and Ki for tetrabutylammonium hydroxide, procaine and physostigmine in the present study. Physostigmine 344-357 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 8784921-1 1996 A method for preparing various forms of acetylcholinesterase (AChE) from human erythrocyte has been established and they have been characterized in terms of kinetic parameters such as K(m), rate constant (k), turnover number (kcat), specificity constant (ksp), Vmax, half-life (t1/2), IC50 and Ki for tetrabutylammonium hydroxide, procaine and physostigmine in the present study. Physostigmine 344-357 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 8710179-6 1996 A small fraction of glioma AChE monomers was released as, or transformed into, hydrophilic forms by incubation with phosphatidylinositol-specific phospholipase C (PIPLC). Phosphatidylinositols 116-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 8724787-4 1996 The rate of decarbamylation of acetylcholinesterase inhibited by aminostigmine measured by the dilution method, by creating excessive acetylcholine and by dialysis is characterized by k2c constants equal to (1.1-1.6).10(-2), (2.5-2.8).10(-2) and 0.025.10(-2) min-1, respectively. aminostigmine 65-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 8619258-0 1996 Oxime-induced reactivation of acetylcholinesterase inhibited by phosphoramidates. Oximes 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 8619258-0 1996 Oxime-induced reactivation of acetylcholinesterase inhibited by phosphoramidates. phosphoramidic acid 64-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 8619258-3 1996 Imidazole oxime BDB-106 proved to be a potent reactivator of tabun-inhibited AChE. imidazole oxime bdb-106 0-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 8829618-2 1996 It was found that 40.0 micrograms protein and 5.0 min incubation time were the suitable concentration of AChE protein and reaction time for the linearity of AChE activity at 25 degrees C. The Vmax for the AChE was 35% higher in the presence of 25 mM sodium phosphate buffer than 25 mM Tris-HCl buffer. sodium phosphate 250-266 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 8829618-2 1996 It was found that 40.0 micrograms protein and 5.0 min incubation time were the suitable concentration of AChE protein and reaction time for the linearity of AChE activity at 25 degrees C. The Vmax for the AChE was 35% higher in the presence of 25 mM sodium phosphate buffer than 25 mM Tris-HCl buffer. sodium phosphate 250-266 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 8829618-2 1996 It was found that 40.0 micrograms protein and 5.0 min incubation time were the suitable concentration of AChE protein and reaction time for the linearity of AChE activity at 25 degrees C. The Vmax for the AChE was 35% higher in the presence of 25 mM sodium phosphate buffer than 25 mM Tris-HCl buffer. sodium phosphate 250-266 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 8829618-2 1996 It was found that 40.0 micrograms protein and 5.0 min incubation time were the suitable concentration of AChE protein and reaction time for the linearity of AChE activity at 25 degrees C. The Vmax for the AChE was 35% higher in the presence of 25 mM sodium phosphate buffer than 25 mM Tris-HCl buffer. Tris hydrochloride 285-293 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 8829618-2 1996 It was found that 40.0 micrograms protein and 5.0 min incubation time were the suitable concentration of AChE protein and reaction time for the linearity of AChE activity at 25 degrees C. The Vmax for the AChE was 35% higher in the presence of 25 mM sodium phosphate buffer than 25 mM Tris-HCl buffer. Tris hydrochloride 285-293 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 8829618-2 1996 It was found that 40.0 micrograms protein and 5.0 min incubation time were the suitable concentration of AChE protein and reaction time for the linearity of AChE activity at 25 degrees C. The Vmax for the AChE was 35% higher in the presence of 25 mM sodium phosphate buffer than 25 mM Tris-HCl buffer. Tris hydrochloride 285-293 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 8829618-3 1996 The AChE activity was assayed at various strengths of sodium phosphate buffer (0.0125-0.20 M), and the optimum strength was found to be 0.05 M. The optimum substrate (ASCh) concentration was found to be 5.0 mM whereas at higher substrate concentrations, the AChE activity declined. sodium phosphate 54-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 8605227-6 1996 The interaction between acetylcholinesterase and several monosaccharide columns observed in this study appeared to be due to ionic interactions. Monosaccharides 57-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 8670655-2 1996 Acetylcholinesterase (AChE), the enzyme responsible for deactivating acetylcholine, is found within both cholinergic axons arising from the basal forebrain and a subgroup of pyramidal cells in layers III and V of the cerebral cortex. Acetylcholine 69-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 8670655-2 1996 Acetylcholinesterase (AChE), the enzyme responsible for deactivating acetylcholine, is found within both cholinergic axons arising from the basal forebrain and a subgroup of pyramidal cells in layers III and V of the cerebral cortex. Acetylcholine 69-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 8900891-6 1996 The results demonstrated that after pyridostigmine erythrocyte-bound as well as synaptic AChE is inhibited. Pyridostigmine Bromide 36-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 8900891-8 1996 After injection of edrophonium-chloride (Tensilon) inhibition of AChE activity can be demonstrated as well. Edrophonium 19-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 8900891-8 1996 After injection of edrophonium-chloride (Tensilon) inhibition of AChE activity can be demonstrated as well. Edrophonium 41-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 8900891-9 1996 During steady pyridostigmine doses stable plasma concentrations and AChE inhibition depend on the respective dosage. Pyridostigmine Bromide 14-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 8608255-6 1996 The RBC membrane cholesterol, phospholipids, and AchE remained higher in EAS 25 than in Adsol (P < .001). CHEMBL4167713 73-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 8608255-7 1996 Vesicle membrane lipids and AchE in EAS 25 were significantly less than in Adsol (P < .001). CHEMBL4167713 36-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 8619826-1 1996 Exposure of purified hydrophilic tetramers of acetylcholinesterase (AChE) from fetal bovine serum to various guanidinium chloride (Gdn) concentrations led to inactive tetramers (2 M Gdn) and dimers (6 M Gdn). Guanidine 109-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 8619826-1 1996 Exposure of purified hydrophilic tetramers of acetylcholinesterase (AChE) from fetal bovine serum to various guanidinium chloride (Gdn) concentrations led to inactive tetramers (2 M Gdn) and dimers (6 M Gdn). Guanidine 109-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 8619826-1 1996 Exposure of purified hydrophilic tetramers of acetylcholinesterase (AChE) from fetal bovine serum to various guanidinium chloride (Gdn) concentrations led to inactive tetramers (2 M Gdn) and dimers (6 M Gdn). Guanidine 131-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 8619826-1 1996 Exposure of purified hydrophilic tetramers of acetylcholinesterase (AChE) from fetal bovine serum to various guanidinium chloride (Gdn) concentrations led to inactive tetramers (2 M Gdn) and dimers (6 M Gdn). Guanidine 131-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 8619826-1 1996 Exposure of purified hydrophilic tetramers of acetylcholinesterase (AChE) from fetal bovine serum to various guanidinium chloride (Gdn) concentrations led to inactive tetramers (2 M Gdn) and dimers (6 M Gdn). Guanidine 182-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 8619826-1 1996 Exposure of purified hydrophilic tetramers of acetylcholinesterase (AChE) from fetal bovine serum to various guanidinium chloride (Gdn) concentrations led to inactive tetramers (2 M Gdn) and dimers (6 M Gdn). Guanidine 182-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 8619826-1 1996 Exposure of purified hydrophilic tetramers of acetylcholinesterase (AChE) from fetal bovine serum to various guanidinium chloride (Gdn) concentrations led to inactive tetramers (2 M Gdn) and dimers (6 M Gdn). Guanidine 182-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 8619826-1 1996 Exposure of purified hydrophilic tetramers of acetylcholinesterase (AChE) from fetal bovine serum to various guanidinium chloride (Gdn) concentrations led to inactive tetramers (2 M Gdn) and dimers (6 M Gdn). Guanidine 182-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 8619826-4 1996 Intrinsic fluorescence spectra and binding of the amphiphilic probe, 1-anilino-8-naphthalene sulfonate (ANS), revealed that AchE subunit in the modified tetramers were in a "molten globule" structure, the dimers in a denatured stated, and the inactive monomers in a "native-like" structure. 1-anilino-8-naphthalenesulfonate 69-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 8619826-4 1996 Intrinsic fluorescence spectra and binding of the amphiphilic probe, 1-anilino-8-naphthalene sulfonate (ANS), revealed that AchE subunit in the modified tetramers were in a "molten globule" structure, the dimers in a denatured stated, and the inactive monomers in a "native-like" structure. 1-anilino-8-naphthalenesulfonate 104-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 8593081-2 1996 Since chlorpyrifos inhibits acetylcholinesterase, the acetylcholine-innervated ciliated epithelial cultures of frog palate were used as the model. Chlorpyrifos 6-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 8867149-3 1996 EC50 values from in vivo AChE inhibition tests were: 2.4 micrograms/l for parathion, 0.2 microgram/l for paraoxon; DCA and cadmium at the concentrations tested had no effects on enzyme activity. Parathion 74-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 8867149-6 1996 Our results indicated that the in vivo AChE inhibition test is selective, being very sensitive to detect toxicity of the organophosphates tested. Organophosphates 121-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 8657729-1 1996 The intensity dependence of the rose bengal (RB)-photosensitized inhibition of red blood cell acetylcholinesterase has been studied experimentally and the results compared to a quantitative excitation/deactivation model of RB photochemistry. Rose Bengal 32-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 8657729-1 1996 The intensity dependence of the rose bengal (RB)-photosensitized inhibition of red blood cell acetylcholinesterase has been studied experimentally and the results compared to a quantitative excitation/deactivation model of RB photochemistry. Rose Bengal 45-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 8657729-7 1996 The results indicated that the photosensitized inhibition of acetylcholinesterase was exclusively mediated by singlet oxygen, even at the highest laser intensities employed. Singlet Oxygen 110-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 8787128-0 1996 In vivo studies of acetylcholinesterase activity using a labeled substrate, N-[11C]methylpiperdin-4-yl propionate ([11C]PMP). n-[11c]methylpiperdin-4-yl propionate 76-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 8787128-0 1996 In vivo studies of acetylcholinesterase activity using a labeled substrate, N-[11C]methylpiperdin-4-yl propionate ([11C]PMP). UNII-S4X91EGA07 115-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 8787128-3 1996 Regional brain distributions after [11C]PMP administration showed better discrimination between regions of high, intermediate, and low AChE activities. Carbon-11 36-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 8787128-3 1996 Regional brain distributions after [11C]PMP administration showed better discrimination between regions of high, intermediate, and low AChE activities. pmp 40-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 8787128-5 1996 For both [11C]AMP and [11C]PMP, retention of radioactivity in all regions was reduced by pretreatment with diisopropylfluorophosphate (DFP), a specific irreversible AChE inhibitor. Carbon-11 10-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 8787128-5 1996 For both [11C]AMP and [11C]PMP, retention of radioactivity in all regions was reduced by pretreatment with diisopropylfluorophosphate (DFP), a specific irreversible AChE inhibitor. Adenosine Monophosphate 14-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 8787128-5 1996 For both [11C]AMP and [11C]PMP, retention of radioactivity in all regions was reduced by pretreatment with diisopropylfluorophosphate (DFP), a specific irreversible AChE inhibitor. Isoflurophate 107-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 8787128-5 1996 For both [11C]AMP and [11C]PMP, retention of radioactivity in all regions was reduced by pretreatment with diisopropylfluorophosphate (DFP), a specific irreversible AChE inhibitor. Isoflurophate 135-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 8787128-7 1996 Radioactivity localization in brain after peripheral injection was thus dependent on AChE-catalyzed hydrolysis to the hydrophilic product N-[11C]methylpiperidinol. n-[11c]methylpiperidinol 138-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 8787128-8 1996 PET imaging of [11C]AMP or [11C]PMP distributions in monkey brain showed clear accumulation of radioactivity in areas of highest AChE activity (striatum, cortex). [11c]amp 15-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 8787128-8 1996 PET imaging of [11C]AMP or [11C]PMP distributions in monkey brain showed clear accumulation of radioactivity in areas of highest AChE activity (striatum, cortex). UNII-S4X91EGA07 27-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 8787128-9 1996 These esters are thus in vivo substrates for brain AChE, with potential applications as in vivo imaging agents of enzyme action in the human brain. Esters 6-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 8605227-3 1996 Previously it was demonstrated that acetylcholinesterase interacted in a carbohydrate-specific manner with peritoneal macrophages and induced the "respiratory burst" [1]. Carbohydrates 73-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 8605227-4 1996 This study aimed to establish whether a carbohydrate-binding site exists on the acetylcholinesterase molecule itself, or alternatively, whether the macrophage carbohydrate-binding receptor is involved. Carbohydrates 40-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 8635584-1 1996 The rate of thermal inactivation of Torpedo AChE at pH 8.5 was increased by the sulfhydryl reagent 5,5"-dithiobis-(2-nitrobenzoic acid) (DTNB). Dithionitrobenzoic Acid 99-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 8635584-1 1996 The rate of thermal inactivation of Torpedo AChE at pH 8.5 was increased by the sulfhydryl reagent 5,5"-dithiobis-(2-nitrobenzoic acid) (DTNB). Dithionitrobenzoic Acid 137-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 8547248-0 1996 Binding of the neurotoxin fasciculin 2 to the acetylcholinesterase peripheral site drastically reduces the association and dissociation rate constants for N-methylacridinium binding to the active site. N-methylacridine 155-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 8547248-4 1996 Like certain other cationic ligands that bind specifically to the acylation site, N-methylacridinium can still interact with the acylation site in the AChE-fasciculin 2 complex. N-methylacridine 82-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 8547248-5 1996 At 310 K (37 degrees C), the equilibrium dissociation constant KL" for N-methylacridinium binding to the complex was 4.0 +/- 0.7 microM, less than an order of magnitude larger than the KL = 1.0 +/- 0.3 microM for N-methylacridinium interaction with human AChE in the absence of fasciculin 2. kl" 63-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 255-259 8547248-5 1996 At 310 K (37 degrees C), the equilibrium dissociation constant KL" for N-methylacridinium binding to the complex was 4.0 +/- 0.7 microM, less than an order of magnitude larger than the KL = 1.0 +/- 0.3 microM for N-methylacridinium interaction with human AChE in the absence of fasciculin 2. N-methylacridine 71-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 255-259 8547248-6 1996 To assess whether fasciculin 2 can sterically block access of a ligand to the acylation site, thermodynamic and kinetic constants for the interaction of N-methylacridinium with AChE in the presence and absence of fasciculin 2 were measured by fluorescence temperature jump relaxation kinetics. N-methylacridine 153-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-181 8783813-0 1996 Reactivation by various oximes of human erythrocyte acetylcholinesterase inhibited by different organophosphorus compounds. Oximes 24-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 8783813-0 1996 Reactivation by various oximes of human erythrocyte acetylcholinesterase inhibited by different organophosphorus compounds. organophosphorus 96-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 8783813-3 1996 For this purpose human erythrocyte AChE (EC 3.1.1.7) was inhibited (30 min) by chlorfenvinphos, dichlorvos, dicrotophos, heptenophos, mevinphos, monocrotophos, paraoxon, phosphamidon, trichlorfon, malaoxon, omethoate, oxydemeton-methyl or methamidophos by 85-98% of control. Chlorfenvinphos 79-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 8783813-3 1996 For this purpose human erythrocyte AChE (EC 3.1.1.7) was inhibited (30 min) by chlorfenvinphos, dichlorvos, dicrotophos, heptenophos, mevinphos, monocrotophos, paraoxon, phosphamidon, trichlorfon, malaoxon, omethoate, oxydemeton-methyl or methamidophos by 85-98% of control. Dichlorvos 96-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 8783813-3 1996 For this purpose human erythrocyte AChE (EC 3.1.1.7) was inhibited (30 min) by chlorfenvinphos, dichlorvos, dicrotophos, heptenophos, mevinphos, monocrotophos, paraoxon, phosphamidon, trichlorfon, malaoxon, omethoate, oxydemeton-methyl or methamidophos by 85-98% of control. heptenophos 121-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 8783813-3 1996 For this purpose human erythrocyte AChE (EC 3.1.1.7) was inhibited (30 min) by chlorfenvinphos, dichlorvos, dicrotophos, heptenophos, mevinphos, monocrotophos, paraoxon, phosphamidon, trichlorfon, malaoxon, omethoate, oxydemeton-methyl or methamidophos by 85-98% of control. Mevinphos 134-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 8783813-3 1996 For this purpose human erythrocyte AChE (EC 3.1.1.7) was inhibited (30 min) by chlorfenvinphos, dichlorvos, dicrotophos, heptenophos, mevinphos, monocrotophos, paraoxon, phosphamidon, trichlorfon, malaoxon, omethoate, oxydemeton-methyl or methamidophos by 85-98% of control. Monocrotophos 145-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 8783813-3 1996 For this purpose human erythrocyte AChE (EC 3.1.1.7) was inhibited (30 min) by chlorfenvinphos, dichlorvos, dicrotophos, heptenophos, mevinphos, monocrotophos, paraoxon, phosphamidon, trichlorfon, malaoxon, omethoate, oxydemeton-methyl or methamidophos by 85-98% of control. Paraoxon 160-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 8783813-3 1996 For this purpose human erythrocyte AChE (EC 3.1.1.7) was inhibited (30 min) by chlorfenvinphos, dichlorvos, dicrotophos, heptenophos, mevinphos, monocrotophos, paraoxon, phosphamidon, trichlorfon, malaoxon, omethoate, oxydemeton-methyl or methamidophos by 85-98% of control. Phosphamidon 170-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 8783813-3 1996 For this purpose human erythrocyte AChE (EC 3.1.1.7) was inhibited (30 min) by chlorfenvinphos, dichlorvos, dicrotophos, heptenophos, mevinphos, monocrotophos, paraoxon, phosphamidon, trichlorfon, malaoxon, omethoate, oxydemeton-methyl or methamidophos by 85-98% of control. Trichlorfon 184-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 8783813-3 1996 For this purpose human erythrocyte AChE (EC 3.1.1.7) was inhibited (30 min) by chlorfenvinphos, dichlorvos, dicrotophos, heptenophos, mevinphos, monocrotophos, paraoxon, phosphamidon, trichlorfon, malaoxon, omethoate, oxydemeton-methyl or methamidophos by 85-98% of control. malaoxon 197-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 8783813-3 1996 For this purpose human erythrocyte AChE (EC 3.1.1.7) was inhibited (30 min) by chlorfenvinphos, dichlorvos, dicrotophos, heptenophos, mevinphos, monocrotophos, paraoxon, phosphamidon, trichlorfon, malaoxon, omethoate, oxydemeton-methyl or methamidophos by 85-98% of control. dimethoxon 207-216 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 8783813-3 1996 For this purpose human erythrocyte AChE (EC 3.1.1.7) was inhibited (30 min) by chlorfenvinphos, dichlorvos, dicrotophos, heptenophos, mevinphos, monocrotophos, paraoxon, phosphamidon, trichlorfon, malaoxon, omethoate, oxydemeton-methyl or methamidophos by 85-98% of control. methyl demeton 218-235 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 8783813-3 1996 For this purpose human erythrocyte AChE (EC 3.1.1.7) was inhibited (30 min) by chlorfenvinphos, dichlorvos, dicrotophos, heptenophos, mevinphos, monocrotophos, paraoxon, phosphamidon, trichlorfon, malaoxon, omethoate, oxydemeton-methyl or methamidophos by 85-98% of control. methamidophos 239-252 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 8783813-5 1996 The oximes significantly, but not completely, reactivated organophosphate inhibited AChE. Oximes 4-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 8783813-5 1996 The oximes significantly, but not completely, reactivated organophosphate inhibited AChE. Organophosphates 58-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 8783813-9 1996 These data suggest that 2-PAM HI 6 and HLo 7 are less patent than obidoxime in reactivating human AChE inhibited by organophosphate pesticides. Obidoxime Chloride 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 8783813-9 1996 These data suggest that 2-PAM HI 6 and HLo 7 are less patent than obidoxime in reactivating human AChE inhibited by organophosphate pesticides. Organophosphates 116-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 23888890-6 1996 With some exceptions, in vitro and in vivo exposures to lead and uranium showed that the AChE, catalase and GPx acbirites were decreased in the three species. Uranium 65-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 23888890-9 1996 Moreover, it was shown that AChE activities wen modulated by metals in viva and cannot be considered as specific bomarken of organophosphorus or carbaw pedcide exposure. organophosphorus 125-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 8828163-4 1996 In the assembled biosensor, the AChE modified mesh was placed over a glassy carbon electrode and the response to 4-aminophenylacetate, used as substrate, was monitored via the enzymatic reaction product, 4-aminophenol, by oxidation at +0.25 V vs. SSCE. Carbon 76-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 8828163-4 1996 In the assembled biosensor, the AChE modified mesh was placed over a glassy carbon electrode and the response to 4-aminophenylacetate, used as substrate, was monitored via the enzymatic reaction product, 4-aminophenol, by oxidation at +0.25 V vs. SSCE. 4-aminophenyl acetate 113-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 8828163-4 1996 In the assembled biosensor, the AChE modified mesh was placed over a glassy carbon electrode and the response to 4-aminophenylacetate, used as substrate, was monitored via the enzymatic reaction product, 4-aminophenol, by oxidation at +0.25 V vs. SSCE. 4-aminophenol 204-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 8828163-5 1996 This approach to biosensor design has been extended to the determination of organophosphorus and carbamate pesticides by their inhibition of AChE enzymatic activity. organophosphorus 76-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 8828163-5 1996 This approach to biosensor design has been extended to the determination of organophosphorus and carbamate pesticides by their inhibition of AChE enzymatic activity. Carbamates 97-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 8565226-1 1996 Monoclonal antibodies (mAbs) were raised against a peptide of the 10 C-terminal amino acids of human brain acetylcholinesterase (AChE): H-Tyr-Ser-Lys-Gln-Asp-Arg-Cys-Ser-Asp-Leu-OH. Tyrosine 138-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 8565226-1 1996 Monoclonal antibodies (mAbs) were raised against a peptide of the 10 C-terminal amino acids of human brain acetylcholinesterase (AChE): H-Tyr-Ser-Lys-Gln-Asp-Arg-Cys-Ser-Asp-Leu-OH. Tyrosine 138-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 8565226-1 1996 Monoclonal antibodies (mAbs) were raised against a peptide of the 10 C-terminal amino acids of human brain acetylcholinesterase (AChE): H-Tyr-Ser-Lys-Gln-Asp-Arg-Cys-Ser-Asp-Leu-OH. Aspartic Acid 154-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 8565226-1 1996 Monoclonal antibodies (mAbs) were raised against a peptide of the 10 C-terminal amino acids of human brain acetylcholinesterase (AChE): H-Tyr-Ser-Lys-Gln-Asp-Arg-Cys-Ser-Asp-Leu-OH. Aspartic Acid 154-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 8565226-1 1996 Monoclonal antibodies (mAbs) were raised against a peptide of the 10 C-terminal amino acids of human brain acetylcholinesterase (AChE): H-Tyr-Ser-Lys-Gln-Asp-Arg-Cys-Ser-Asp-Leu-OH. Aspartic Acid 170-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 8565226-1 1996 Monoclonal antibodies (mAbs) were raised against a peptide of the 10 C-terminal amino acids of human brain acetylcholinesterase (AChE): H-Tyr-Ser-Lys-Gln-Asp-Arg-Cys-Ser-Asp-Leu-OH. Aspartic Acid 170-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 8785468-13 1996 The cholinomimetic drugs, especially the acetylcholinesterase inhibitor tacrine, have provided a very modest benefit, slowing the progression of the illness for a number of months. Tacrine 72-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 8821672-1 1996 The neurotoxicity of organophosphorus (OP) compounds involves the inhibition of acetylcholinesterase (AChE), causing accumulation of acetylcholine (ACh) at synapses. organophosphorus 21-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 8821672-1 1996 The neurotoxicity of organophosphorus (OP) compounds involves the inhibition of acetylcholinesterase (AChE), causing accumulation of acetylcholine (ACh) at synapses. organophosphorus 21-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 8821672-1 1996 The neurotoxicity of organophosphorus (OP) compounds involves the inhibition of acetylcholinesterase (AChE), causing accumulation of acetylcholine (ACh) at synapses. Acetylcholine 80-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 8821672-1 1996 The neurotoxicity of organophosphorus (OP) compounds involves the inhibition of acetylcholinesterase (AChE), causing accumulation of acetylcholine (ACh) at synapses. Acetylcholine 102-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 8747488-0 1995 Acetylcholinesterase of human intestinal tissue affected by Hirschsprung"s disease: effect of magnesium chloride on isoforms. Magnesium Chloride 94-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 8747488-9 1995 The use of 2-4 mol/l MgCl2 in histochemical AChE staining reduces the activity slightly but does not differentiate the tetrameric AChE isoform that is increased in Hirschsprung"s disease but does reduce contaminating erythrocyte AChE levels that can obscure the result in blood-stained biopsies. Magnesium Chloride 21-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 8530502-1 1995 We investigated the intracellular events involved in the 3,3",5-triiodo-L-thyronine (T3)-induced accumulation in acetylcholinesterase (AChE) activity in neuroblastoma cells (neuro-2a) that overexpress the human thyroid receptor beta 1 (hTR beta 1). 3,3",5-triiodo-l-thyronine 57-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-133 8530502-1 1995 We investigated the intracellular events involved in the 3,3",5-triiodo-L-thyronine (T3)-induced accumulation in acetylcholinesterase (AChE) activity in neuroblastoma cells (neuro-2a) that overexpress the human thyroid receptor beta 1 (hTR beta 1). 3,3",5-triiodo-l-thyronine 57-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 8530502-1 1995 We investigated the intracellular events involved in the 3,3",5-triiodo-L-thyronine (T3)-induced accumulation in acetylcholinesterase (AChE) activity in neuroblastoma cells (neuro-2a) that overexpress the human thyroid receptor beta 1 (hTR beta 1). Triiodothyronine 85-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-133 8530502-1 1995 We investigated the intracellular events involved in the 3,3",5-triiodo-L-thyronine (T3)-induced accumulation in acetylcholinesterase (AChE) activity in neuroblastoma cells (neuro-2a) that overexpress the human thyroid receptor beta 1 (hTR beta 1). Triiodothyronine 85-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 8830310-3 1995 We report here that AChE binds A beta nac and accelerates amyloid formation by the same peptide. nac 38-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 8846227-4 1995 AChE inhibitors, physostigmine and Tacrine can slow the decline of cognitive function and memory in some patients with mild or moderate AD, if given for at least 3-6 months in sufficient doses to inhibit brain AChE. Physostigmine 17-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-214 8846227-4 1995 AChE inhibitors, physostigmine and Tacrine can slow the decline of cognitive function and memory in some patients with mild or moderate AD, if given for at least 3-6 months in sufficient doses to inhibit brain AChE. Tacrine 35-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-214 8846227-6 1995 Newer, less toxic AChE inhibitors, with selective central activity, formulations of physostigmine, selective Ml and nicotinic agonists are becoming available with improved bioavailability and pharmacokinetics. Physostigmine 84-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 7492545-1 1995 Replacement of residues Asp74, Trp286, and Tyr72, which are constituents of the peripheral anionic site (PAS) of human acetylcholinesterase (HuAChE), affected similarly both the binding and the inhibition constants of the PAS-specific ligand propidium, demonstrating that changes in the inhibitory activity are a direct consequence of altered binding to the PAS. Aminosalicylic Acid 105-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 7492545-1 1995 Replacement of residues Asp74, Trp286, and Tyr72, which are constituents of the peripheral anionic site (PAS) of human acetylcholinesterase (HuAChE), affected similarly both the binding and the inhibition constants of the PAS-specific ligand propidium, demonstrating that changes in the inhibitory activity are a direct consequence of altered binding to the PAS. Aminosalicylic Acid 222-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 7492545-1 1995 Replacement of residues Asp74, Trp286, and Tyr72, which are constituents of the peripheral anionic site (PAS) of human acetylcholinesterase (HuAChE), affected similarly both the binding and the inhibition constants of the PAS-specific ligand propidium, demonstrating that changes in the inhibitory activity are a direct consequence of altered binding to the PAS. Propidium 242-251 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 7492545-1 1995 Replacement of residues Asp74, Trp286, and Tyr72, which are constituents of the peripheral anionic site (PAS) of human acetylcholinesterase (HuAChE), affected similarly both the binding and the inhibition constants of the PAS-specific ligand propidium, demonstrating that changes in the inhibitory activity are a direct consequence of altered binding to the PAS. Aminosalicylic Acid 222-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 8595207-1 1995 Huperzine A, a novel, potent, reversible, and selective acetylcholinesterase (AChE) inhibitor has been expected to be superior to other AChE inhibitors now for the treatment of memory deficits in patients with Alzheimer"s disease. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 8595207-1 1995 Huperzine A, a novel, potent, reversible, and selective acetylcholinesterase (AChE) inhibitor has been expected to be superior to other AChE inhibitors now for the treatment of memory deficits in patients with Alzheimer"s disease. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 8595207-1 1995 Huperzine A, a novel, potent, reversible, and selective acetylcholinesterase (AChE) inhibitor has been expected to be superior to other AChE inhibitors now for the treatment of memory deficits in patients with Alzheimer"s disease. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 8615775-4 1996 The glycan structure is completely consistent with that obtained previously for the GPI anchor of human erythrocyte AChE except for the addition of the HexNAc substituent. Polysaccharides 4-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 8615775-8 1996 Dimerization of AChE polypeptides is mediated by intersubunit disulphide bonding in this C-terminal segment, but the bovine AChE contained two cysteine residues in a ...CTC... motif, in contrast with human AChE which contains only a single cysteine in this segment. Cysteine 143-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 8615775-8 1996 Dimerization of AChE polypeptides is mediated by intersubunit disulphide bonding in this C-terminal segment, but the bovine AChE contained two cysteine residues in a ...CTC... motif, in contrast with human AChE which contains only a single cysteine in this segment. Cysteine 240-248 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 8558505-0 1996 A comparative molecular field analysis study of N-benzylpiperidines as acetylcholinesterase inhibitors. 1-benzylpiperidine 48-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 8558505-2 1996 These compounds have been found to inhibit the metabolic breakdown of the neurotransmitter acetylcholine (ACh) by the enzyme acetylcholinesterase (AChE) and hence alleviate memory deficits in patients with Alzheimer"s Disease by potentiating cholinergic transmission. Acetylcholine 91-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 8558505-2 1996 These compounds have been found to inhibit the metabolic breakdown of the neurotransmitter acetylcholine (ACh) by the enzyme acetylcholinesterase (AChE) and hence alleviate memory deficits in patients with Alzheimer"s Disease by potentiating cholinergic transmission. Acetylcholine 91-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 8558505-2 1996 These compounds have been found to inhibit the metabolic breakdown of the neurotransmitter acetylcholine (ACh) by the enzyme acetylcholinesterase (AChE) and hence alleviate memory deficits in patients with Alzheimer"s Disease by potentiating cholinergic transmission. Acetylcholine 106-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 8558505-2 1996 These compounds have been found to inhibit the metabolic breakdown of the neurotransmitter acetylcholine (ACh) by the enzyme acetylcholinesterase (AChE) and hence alleviate memory deficits in patients with Alzheimer"s Disease by potentiating cholinergic transmission. Acetylcholine 106-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 8911635-2 1996 Although oximes have been designed to reactivate the inhibited acetylcholinesterase (AChE), clinical experience has indicated that they are not always very effective as reactivators and at this very moment none of them can be regarded as a broad-spectrum antidote. Oximes 9-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 8911635-2 1996 Although oximes have been designed to reactivate the inhibited acetylcholinesterase (AChE), clinical experience has indicated that they are not always very effective as reactivators and at this very moment none of them can be regarded as a broad-spectrum antidote. Oximes 9-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 8911635-3 1996 In spite of this drawback, oximes are worth further investigating, since recent data derived from soman or tabun lethally intoxicated non-human primates suggest that the oxime HI-6 may exert a pharmacological effect that is not related to reactivation of inhibited AChE, but still leads to survival. asoxime chloride 176-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 265-269 8768334-1 1996 The data of long-standing research allowed to establish correlation between oxygen consumption different at various age and catecholamine (CA) content and acetylcholinesterase (AChE) activity in blood. Oxygen 76-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-181 8534412-2 1995 With one acetylcholinesterase (AChE) inhibitor compound (velnacrine), we found that AD patients tolerated considerably lower dosages than young normals and healthy elderly subjects, whereas our findings were exactly the opposite with another AChE inhibitor (eptastigmine). velnacrine 57-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 8830310-4 1995 No such effect was observed with A beta ac, the amyloidogenic conformer, suggesting that AChE acts as a "pathological chaperone" inducing a conformational transition from A beta nac into A beta ac in vitro. nac 178-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 8534412-2 1995 With one acetylcholinesterase (AChE) inhibitor compound (velnacrine), we found that AD patients tolerated considerably lower dosages than young normals and healthy elderly subjects, whereas our findings were exactly the opposite with another AChE inhibitor (eptastigmine). velnacrine 57-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 8534412-2 1995 With one acetylcholinesterase (AChE) inhibitor compound (velnacrine), we found that AD patients tolerated considerably lower dosages than young normals and healthy elderly subjects, whereas our findings were exactly the opposite with another AChE inhibitor (eptastigmine). velnacrine 57-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 242-246 7491557-1 1995 BACKGROUND: Pyridostigmine, an acetylcholinesterase antagonist, is useful in improving respiratory function in patients with myasthenia gravis. Pyridostigmine Bromide 12-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 8561923-3 1995 In vivo inhibition of whole body AChE reveals higher degree of inhibition by LD50 dose of Methyl parathion as compared to that of Carbaryl where maximum inhibition was noticed at the agricultural dose. Methyl Parathion 90-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 8561923-3 1995 In vivo inhibition of whole body AChE reveals higher degree of inhibition by LD50 dose of Methyl parathion as compared to that of Carbaryl where maximum inhibition was noticed at the agricultural dose. Carbaryl 130-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 9383467-3 1995 We set out to apply this method to develop more effective analogs of the known, marketed drug tacrine, an acetylcholinesterase inhibitor. Tacrine 94-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 8704594-1 1995 The inhibitory activity of O-carbamoyl acylhydroxymoylchlorides was studied on the purified specimens of acetylcholinesterase from human erythrocytes and butirylcholinesterase from the horse blood serum. o-carbamoyl acylhydroxymoylchlorides 27-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 7584632-0 1995 Kinetics for the inhibition of acetylcholinesterase from human erythrocyte by cisplatin. Cisplatin 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 7584632-2 1995 Since acetylcholine plays a key role in human neurotransmission we characterized the inhibitory effect of cisplatin on the enzyme, acetylcholinesterase. Acetylcholine 6-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-151 7584632-2 1995 Since acetylcholine plays a key role in human neurotransmission we characterized the inhibitory effect of cisplatin on the enzyme, acetylcholinesterase. Cisplatin 106-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-151 7584632-10 1995 These studies show that cisplatin is an uncompetitive inhibitor of acetylcholinesterase. Cisplatin 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 7657613-4 1995 We show that Trp86 is important for the alignment of carboxyl ester substrates in the AChE active center. carboxyl ester 53-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 7657613-8 1995 Analysis of the kinetics of acylation by organophosphates and conjugation by trifluoroacetophenones, along with deconstruction of the kinetic constants for carboxyl esters, suggests that AChE inhibition by fasciculin arises from reductions of both the commitment to catalysis and diffusional entry of substrate into the gorge. Organophosphates 41-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 7657613-8 1995 Analysis of the kinetics of acylation by organophosphates and conjugation by trifluoroacetophenones, along with deconstruction of the kinetic constants for carboxyl esters, suggests that AChE inhibition by fasciculin arises from reductions of both the commitment to catalysis and diffusional entry of substrate into the gorge. trifluoroacetophenones 77-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 7657613-8 1995 Analysis of the kinetics of acylation by organophosphates and conjugation by trifluoroacetophenones, along with deconstruction of the kinetic constants for carboxyl esters, suggests that AChE inhibition by fasciculin arises from reductions of both the commitment to catalysis and diffusional entry of substrate into the gorge. carboxyl esters 156-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 7658452-1 1995 A series of 5-amino-5,6,7,8-tetrahydroquinolinones was designed and synthesized as acetylcholinesterase inhibitors. 5-amino-5,6,7,8-tetrahydroquinolinones 12-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 7658452-3 1995 They inhibit acetylcholinesterase in vitro, and many are active in vivo in reversing a scopolamine-induced impairment of 24 h memory in a passive avoidance paradigm. Scopolamine 87-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-33 7643875-7 1995 In the patient controls, pancuronium 4 mg induced a severe neuromuscular block but not with 1 and 2 mg. Pancuronium dosages necessary to reverse severe OP-induced neuromuscular blockade produce a neuromuscular block when AChE activity is normal. Pancuronium 25-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 221-225 7643875-7 1995 In the patient controls, pancuronium 4 mg induced a severe neuromuscular block but not with 1 and 2 mg. Pancuronium dosages necessary to reverse severe OP-induced neuromuscular blockade produce a neuromuscular block when AChE activity is normal. Pancuronium 104-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 221-225 8545050-1 1995 We have previously shown that treatment of cultured dorsal root ganglion neurons (DRGN) with a highly specific, reversible acetylcholinesterase (AChE) inhibitor, BW284c51, retards neuritic outgrowth in a dose dependent manner and is accompanied by the presence of abnormal, perikaryal neurofilament (NF) inclusions in approximately 40% of the cells. Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide 162-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-143 8545050-1 1995 We have previously shown that treatment of cultured dorsal root ganglion neurons (DRGN) with a highly specific, reversible acetylcholinesterase (AChE) inhibitor, BW284c51, retards neuritic outgrowth in a dose dependent manner and is accompanied by the presence of abnormal, perikaryal neurofilament (NF) inclusions in approximately 40% of the cells. Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide 162-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 7478260-0 1995 Monomers and dimers of acetylcholinesterase in human meningioma are anchored to the membrane by glycosylphosphatidylinositol. Glycosylphosphatidylinositols 96-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 7478260-1 1995 Amphiphilic monomers and dimers of acetylcholinesterase (AChE) and hydrophilic tetramers of butyrylcholinesterase (BuChE) were released by extracting human meningioma with Tris-saline and Tris-saline-Triton X-100 buffers. tris-saline 172-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 7478260-1 1995 Amphiphilic monomers and dimers of acetylcholinesterase (AChE) and hydrophilic tetramers of butyrylcholinesterase (BuChE) were released by extracting human meningioma with Tris-saline and Tris-saline-Triton X-100 buffers. tris-saline 172-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 7478260-2 1995 The amphiphilic or hydrophilic behavior of the AChE and BuChE forms was assessed by sedimentation analysis, hydrophobic chromatography and Triton X-114 phase-partitioning. Nonidet P-40 139-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 7478260-3 1995 A significant fraction of the amphiphilic AChE species was converted into hydrophilic components by incubation of the soluble enzyme with phosphatidylinositol-specific phospholipase C (PIPLC) from Bacillus thuringiensis, this fraction being increased by a double treatment with PIPLC and alkaline hydroxylamine. Phosphatidylinositols 138-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 7478260-3 1995 A significant fraction of the amphiphilic AChE species was converted into hydrophilic components by incubation of the soluble enzyme with phosphatidylinositol-specific phospholipase C (PIPLC) from Bacillus thuringiensis, this fraction being increased by a double treatment with PIPLC and alkaline hydroxylamine. alkaline hydroxylamine 288-310 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 7478260-5 1995 These results demonstrate that AChE forms in meningioma are attached to the membrane via glycosylphosphatidylinositol, although part of the enzyme forms are resistant to PIPLC. Glycosylphosphatidylinositols 89-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 8535296-0 1995 Mercuric chloride effects on the kinetic parameters of human erythrocyte membrane bound acetylcholinesterase. Chlorides 9-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 8535296-1 1995 Kinetic analysis of the interaction of mercuric chloride with human erythrocyte acetylcholinesterase was investigated in the present study. Mercuric Chloride 39-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 8535296-2 1995 It was found that mercuric chloride reversibly inhibited the AChE activity in a concentration dependent manner, the IC50 being 16 microM while the IC100 was 47 microM. Mercuric Chloride 18-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 8535296-3 1995 The Km for the hydrolysis of acetylthiocholine iodide by AChE was found to be 97 microM in the control system, and the value increased by 16-144% in the mercuric chloride treated systems. acetylthiocholine iodide 29-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 8535296-3 1995 The Km for the hydrolysis of acetylthiocholine iodide by AChE was found to be 97 microM in the control system, and the value increased by 16-144% in the mercuric chloride treated systems. Mercuric Chloride 153-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 8535413-0 1995 Kinetic study on the inhibition of acetylcholinesterase by 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride (E2020). Donepezil 59-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 7636741-5 1995 The purpose of this study was to determine the selectivity of physostigmine, metrifonate, methanesulfonyl fluoride and tetrahydroaminoacridine (tacrine) toward AChE as compared with butyrylcholinesterase (BChE) in human cortex. Physostigmine 62-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 7636741-5 1995 The purpose of this study was to determine the selectivity of physostigmine, metrifonate, methanesulfonyl fluoride and tetrahydroaminoacridine (tacrine) toward AChE as compared with butyrylcholinesterase (BChE) in human cortex. Trichlorfon 77-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 7636741-5 1995 The purpose of this study was to determine the selectivity of physostigmine, metrifonate, methanesulfonyl fluoride and tetrahydroaminoacridine (tacrine) toward AChE as compared with butyrylcholinesterase (BChE) in human cortex. methanesulfonyl fluoride 90-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 7636741-5 1995 The purpose of this study was to determine the selectivity of physostigmine, metrifonate, methanesulfonyl fluoride and tetrahydroaminoacridine (tacrine) toward AChE as compared with butyrylcholinesterase (BChE) in human cortex. Tacrine 119-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 9383467-5 1995 The resulting library of (formally) 72 tetrahydroacridines was screened against acetylcholinesterase, and a compound 10-fold more potent than tacrine, 7-nitrotacrine, was discovered. tetrahydroacridines 39-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 9383467-5 1995 The resulting library of (formally) 72 tetrahydroacridines was screened against acetylcholinesterase, and a compound 10-fold more potent than tacrine, 7-nitrotacrine, was discovered. Tacrine 142-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 9383467-5 1995 The resulting library of (formally) 72 tetrahydroacridines was screened against acetylcholinesterase, and a compound 10-fold more potent than tacrine, 7-nitrotacrine, was discovered. 7-nitrotacrine 151-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 9383467-6 1995 Its increased potency could be readily explained by examining the known structure of the complex of acetylcholinesterase with tetrahydroacridine. 1,2,3,4-Tetrahydroacridine 126-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 9383467-7 1995 CONCLUSIONS: In this work, we have provided a relatively rare example of carbon-carbon bond formation in a pool synthesis and have discovered a potentially useful acetylcholinesterase inhibitor. Carbon 73-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-183 9383467-7 1995 CONCLUSIONS: In this work, we have provided a relatively rare example of carbon-carbon bond formation in a pool synthesis and have discovered a potentially useful acetylcholinesterase inhibitor. Carbon 80-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-183 7628183-0 1995 Acetylcholinesterase inhibition by zifrosilone: pharmacokinetics and pharmacodynamics. zifrosilone 35-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 7628183-1 1995 OBJECTIVE: To determine the pharmacokinetics, pharmacodynamics and safety of the acetylcholinesterase inhibitor zifrosilone in healthy male volunteers. zifrosilone 112-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 7628183-9 1995 For doses > or = 200 mg, an Emax pharmacodynamic model was used to describe the relationship between zifrosilone plasma concentration and red blood cell acetylcholinesterase inhibition (Emax = 83.8%; EC50 = 0.65 ng/ml). zifrosilone 104-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-176 7628183-10 1995 CONCLUSIONS: Zifrosilone showed dose-dependent pharmacokinetics after oral administration and was effective in causing selective inhibition of red blood cell acetylcholinesterase. zifrosilone 13-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-178 8714372-1 1995 Hexadecamethonium as well as its alkylating derivatives significantly decrease the effect of organophosphorous acetylcholinesterase inhibitor armine on the amplitude and duration of the EPPs. hexadecamethonium 0-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 8527921-1 1995 Acridine ligand affinity chromatography is an effective means of acetylcholinesterase (AChE) purification. Acridines 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 8527921-1 1995 Acridine ligand affinity chromatography is an effective means of acetylcholinesterase (AChE) purification. Acridines 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 8527921-3 1995 We have developed an acridine ligand affinity resin that is easy to produce, inexpensive, and selective for AChE over butyrylcholinesterase. Acridines 21-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 8527921-12 1995 Overall, the tacrine affinity resin which is simple and inexpensive to produce allows for the selective isolation of AChE from diverse biological matrices. Tacrine 13-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 8545597-3 1995 Free fatty acids and corresponding aliphatic aldehydes induced an inhibition of membrane-bound AChE, effectively decreased the bulk lipid and protein-bound lipid microviscosity, and quenched the fluorescence of membrane-bound ANS. Fatty Acids, Nonesterified 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 8545597-3 1995 Free fatty acids and corresponding aliphatic aldehydes induced an inhibition of membrane-bound AChE, effectively decreased the bulk lipid and protein-bound lipid microviscosity, and quenched the fluorescence of membrane-bound ANS. aliphatic aldehydes 35-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 8545597-3 1995 Free fatty acids and corresponding aliphatic aldehydes induced an inhibition of membrane-bound AChE, effectively decreased the bulk lipid and protein-bound lipid microviscosity, and quenched the fluorescence of membrane-bound ANS. 1-anilino-8-naphthalenesulfonate 226-229 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 7619798-1 1995 Molecular mechanics and dynamics combined with semiempirical calculations were carried out for purposes of comparison of the active site characteristics of AChE, trypsin, and chymotrypsin as probed by their diastereomeric adducts with 2-(3,3-dimethylbutyl) methylphosphonofluoridate (soman), methylphosphonate monoester anions, and tetravalent carbonyl intermediates of the reactions of the natural substrates in each case. 2-(3,3-dimethylbutyl) methylphosphonofluoridate 235-282 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-160 7619798-1 1995 Molecular mechanics and dynamics combined with semiempirical calculations were carried out for purposes of comparison of the active site characteristics of AChE, trypsin, and chymotrypsin as probed by their diastereomeric adducts with 2-(3,3-dimethylbutyl) methylphosphonofluoridate (soman), methylphosphonate monoester anions, and tetravalent carbonyl intermediates of the reactions of the natural substrates in each case. Soman 284-289 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-160 7619798-1 1995 Molecular mechanics and dynamics combined with semiempirical calculations were carried out for purposes of comparison of the active site characteristics of AChE, trypsin, and chymotrypsin as probed by their diastereomeric adducts with 2-(3,3-dimethylbutyl) methylphosphonofluoridate (soman), methylphosphonate monoester anions, and tetravalent carbonyl intermediates of the reactions of the natural substrates in each case. methylphosphonate monoester anions 292-326 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-160 7619798-3 1995 "Pushing" of an alkoxy ligand by Glu199 and the numerous small van der Waals interactions promote dealkylation in phosphonate adducts of AChE much more effectively than any other enzyme. Organophosphonates 114-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 7619798-5 1995 Stabilization of the developing negative charge on the phosphonates in the soman-inhibited PSCS adducts of serine hydrolases is by electrophilic residues in the oxyanion hole (AChE) and the protonated catalytic His. Organophosphonates 55-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 7619798-5 1995 Stabilization of the developing negative charge on the phosphonates in the soman-inhibited PSCS adducts of serine hydrolases is by electrophilic residues in the oxyanion hole (AChE) and the protonated catalytic His. Histidine 211-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 7636741-5 1995 The purpose of this study was to determine the selectivity of physostigmine, metrifonate, methanesulfonyl fluoride and tetrahydroaminoacridine (tacrine) toward AChE as compared with butyrylcholinesterase (BChE) in human cortex. Tacrine 144-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 7636741-6 1995 The results show that methanesulfonyl fluoride is selective as an inhibitor of AChE as compared with BChE. methanesulfonyl fluoride 22-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 7636741-7 1995 Physostigmine inhibited AChE more than BChE. Physostigmine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 7636741-8 1995 Metrifonate was found to inhibit BChE more than AChE. Trichlorfon 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 7558197-3 1995 Centrophenoxine, usually considered as an ageing reversal drug and also regarded as a neuroenergeticum in human therapy, increased the acetylcholinesterase activity in the hippocampus of aged rats, the activity was also elevated in the brain stem but no in the cerebellum. Meclofenoxate 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 7576821-5 1995 Inhibition of AChE by fenthion, which has ready access to central neurons on account of its lipid solubility, is postulated as the mechanism underlying the extrapyramidal manifestations. Fenthion 22-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 7794533-1 1995 A large-scale preparation of a recombinant human acetylcholinesterase (rhAChE) mutant harbouring a CyS580-->Ser substitution, expressed in Escherichia coli, was refolded following solubilization of the inclusion bodies. Serine 111-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 7794533-2 1995 Refolded active rhAChE was purified by DEAE-Sepharose and affinity chromatography to apparent homogeneity with a specific activity (4572 units/mg) similar to that of erythrocyte AChE. deae-sepharose 39-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 7794533-7 1995 This secondary structure is similar to that determined for the Torpedo (electric fish) AChE, by both CD and X-ray crystallography. Cadmium 101-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 7624918-0 1995 A patient-side technique for real-time measurement of acetylcholinesterase activity during monitoring of eptastigmine treatment. physostigmine heptyl 105-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 7599168-1 1995 Both propidium and monoclonal antibody (mAb) 25B1 bind to the peripheral anionic site region of fetal bovine serum acetylcholinesterase (FBS AChE). Propidium 5-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 7599168-2 1995 Using electron paramagnetic resonance (EPR) with spin-labelled organophosphate specifically bound to the AChE active-site serine, we studied the effects of both ligands on the topography of the AChE active-site gorge. Organophosphates 63-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 7544702-1 1995 Esterase activity of endogenous transiently expressed acetylcholinesterase was locally suppressed in visual cortex of infant rats for 2-5 days by the irreversible inhibitor phospholine iodide, delivered from Elvax implants. Echothiophate Iodide 173-191 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 7661856-0 1995 [Conformational differences in the sorption of choline ligands at the active site of acetylcholinesterase]. Choline 47-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 7836436-0 1995 Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase. Tyrosine 37-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-164 7750137-3 1995 A thiocholine method revealed that AChE activity was localized in the subventral glands, which have a secretory and excretory function via a duct connected to the excretory pore. Thiocholine 2-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 7750137-7 1995 When AChE activity in the nematode excretory-secretory product was examined by SDS polyacrylamide gel electrophoresis combined with the thiocholine method, intense activity was demonstrated as a single band at 74 kDa. Sodium Dodecyl Sulfate 79-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 7750137-7 1995 When AChE activity in the nematode excretory-secretory product was examined by SDS polyacrylamide gel electrophoresis combined with the thiocholine method, intense activity was demonstrated as a single band at 74 kDa. polyacrylamide 83-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 7750137-7 1995 When AChE activity in the nematode excretory-secretory product was examined by SDS polyacrylamide gel electrophoresis combined with the thiocholine method, intense activity was demonstrated as a single band at 74 kDa. Thiocholine 136-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 7613468-4 1995 Loop I contains an arginine at position 11, which is found only in the fasciculins and could form a pivotal anchoring point to AChE. Arginine 19-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 7744733-1 1995 The collagen-tailed form of acetylcholinesterase (AChE) binds to heparin and heparan sulfate proteoglycans. Heparin 65-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 7744733-2 1995 We have employed synthetic peptides corresponding to the central collagenic region of the tail of AChE, to identify the heparin-binding domains of the tail of asymmetric AChE. Heparin 120-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 7744733-2 1995 We have employed synthetic peptides corresponding to the central collagenic region of the tail of AChE, to identify the heparin-binding domains of the tail of asymmetric AChE. Heparin 120-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 7744733-4 1995 Peptides containing such sequences (P-(145-159) and P-(249-262)) were able to release asymmetric AChE bound to heparin-agarose. Heparin 111-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 7744733-4 1995 Peptides containing such sequences (P-(145-159) and P-(249-262)) were able to release asymmetric AChE bound to heparin-agarose. Sepharose 119-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 7744733-5 1995 A triple mutation, Asn-Asp-Gly-Gly instead of Arg-His-Gly-Arg, completely abolishes the capacity of the peptide P-(145-159) to elute AChE from the heparin column. Asn-Asp-Gly 19-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 7744733-5 1995 A triple mutation, Asn-Asp-Gly-Gly instead of Arg-His-Gly-Arg, completely abolishes the capacity of the peptide P-(145-159) to elute AChE from the heparin column. Glycine 27-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 7744733-5 1995 A triple mutation, Asn-Asp-Gly-Gly instead of Arg-His-Gly-Arg, completely abolishes the capacity of the peptide P-(145-159) to elute AChE from the heparin column. Glycine 31-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 7744733-5 1995 A triple mutation, Asn-Asp-Gly-Gly instead of Arg-His-Gly-Arg, completely abolishes the capacity of the peptide P-(145-159) to elute AChE from the heparin column. Arginine 58-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 7671443-2 1995 Organophosphates can cause acute toxicity, which follows inhibition of acetylcholinesterase (AChE), or delayed neuropathy, which follows inhibition of neuropathy target esterase (NTE). Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 7671443-2 1995 Organophosphates can cause acute toxicity, which follows inhibition of acetylcholinesterase (AChE), or delayed neuropathy, which follows inhibition of neuropathy target esterase (NTE). Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 7671443-6 1995 Organophosphates actively able to inhibit AChE in animal models inhibited AChE in neuroblastoma cells. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 7671443-6 1995 Organophosphates actively able to inhibit AChE in animal models inhibited AChE in neuroblastoma cells. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 7890775-0 1995 Amino acid residues controlling reactivation of organophosphonyl conjugates of acetylcholinesterase by mono- and bisquaternary oximes. organophosphonyl 48-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 7890775-0 1995 Amino acid residues controlling reactivation of organophosphonyl conjugates of acetylcholinesterase by mono- and bisquaternary oximes. mono- and bisquaternary oximes 103-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 7539985-3 1995 After uv irradiation and methanol treatment, the covalently linked L-thyroxine is measured using the same monoclonal anti-L-thyroxine antibody labeled with acetylcholinesterase. Thyroxine 67-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-176 7836436-0 1995 Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase. Tryptophan 77-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-164 7836436-1 1995 Substitution of Trp-86, in the active center of human acetylcholinesterase (HuAChE), by aliphatic but not by aromatic residues resulted in a several thousandfold decrease in reactivity toward charged substrate and inhibitors but only a severalfold decrease for noncharged substrate and inhibitors. Tryptophan 16-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 7836436-7 1995 It is proposed that allosteric modulation of acetylcholinesterase activity, induced by binding to the peripheral anionic sites, proceeds through such conformational change of Trp-86 from a functional anionic subsite state to one that restricts access of substrates to the active center. Tryptophan 175-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 7744305-0 1995 A possible interaction between acetylcholinesterase and dopamine molecules during autoxidation of the amine. Amines 59-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 7744305-2 1995 This study explored the possible interaction between the two molecules: the effects of acetylcholinesterase on the autoxidation of the catecholamine were tested, and, in turn, modification of the catalytic activity of the enzyme by products of dopamine oxidation were studied. Catecholamines 135-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 7744305-3 1995 Acetylcholinesterase selectively inhibited the speed of quinone production from dopamine as well as accumulation of hydrogen peroxide, whilst the rate of generation of superoxide was increased. quinone 56-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 7744305-3 1995 Acetylcholinesterase selectively inhibited the speed of quinone production from dopamine as well as accumulation of hydrogen peroxide, whilst the rate of generation of superoxide was increased. Dopamine 80-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 7744305-3 1995 Acetylcholinesterase selectively inhibited the speed of quinone production from dopamine as well as accumulation of hydrogen peroxide, whilst the rate of generation of superoxide was increased. Hydrogen Peroxide 116-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 7744305-6 1995 Incubation of acetylcholinesterase in the presence of dopamine resulted in a significant decrease in the catalytic activity of the enzyme. Dopamine 54-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 7830078-1 1995 Monoclonal antibodies were generated against fetal bovine serum acetylcholinesterase and fetal bovine serum acetylcholinesterase inhibited by diisopropyl fluorophosphate or 7-(methylethoxyphosphinyloxy)-1-methylquinolinium iodide. Isoflurophate 142-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 7830078-1 1995 Monoclonal antibodies were generated against fetal bovine serum acetylcholinesterase and fetal bovine serum acetylcholinesterase inhibited by diisopropyl fluorophosphate or 7-(methylethoxyphosphinyloxy)-1-methylquinolinium iodide. 7-((methylethoxyphosphinyl)oxy)-1-methylquinolinium 173-229 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 7830078-8 1995 Monoclonal antibodies that inhibited acetylcholinesterase activity at > 98% also considerably slowed binding of diisopropyl fluorophosphate and other organophosphorus compounds to the acetylcholinesterase:monoclonal antibody complex. Isoflurophate 115-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 7830078-8 1995 Monoclonal antibodies that inhibited acetylcholinesterase activity at > 98% also considerably slowed binding of diisopropyl fluorophosphate and other organophosphorus compounds to the acetylcholinesterase:monoclonal antibody complex. Isoflurophate 115-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-207 7830078-8 1995 Monoclonal antibodies that inhibited acetylcholinesterase activity at > 98% also considerably slowed binding of diisopropyl fluorophosphate and other organophosphorus compounds to the acetylcholinesterase:monoclonal antibody complex. organophosphorus 153-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 7830078-8 1995 Monoclonal antibodies that inhibited acetylcholinesterase activity at > 98% also considerably slowed binding of diisopropyl fluorophosphate and other organophosphorus compounds to the acetylcholinesterase:monoclonal antibody complex. organophosphorus 153-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-207 7531775-3 1995 Because chlorpyrifos and other OP insecticides are designed to produce acute cholinergic effects through inhibition of acetylcholinesterase (AChE) and some OP compounds can cause OP compound-induced delayed neurotoxicity (OPIDN) via chemical modification of neurotoxic esterase (neuropathy target esterase, NTE), this review focuses on the capacity of chlorpyrifos to precipitate these and other adverse neurological consequences. Chlorpyrifos 8-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 7531775-3 1995 Because chlorpyrifos and other OP insecticides are designed to produce acute cholinergic effects through inhibition of acetylcholinesterase (AChE) and some OP compounds can cause OP compound-induced delayed neurotoxicity (OPIDN) via chemical modification of neurotoxic esterase (neuropathy target esterase, NTE), this review focuses on the capacity of chlorpyrifos to precipitate these and other adverse neurological consequences. Chlorpyrifos 8-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 7531775-3 1995 Because chlorpyrifos and other OP insecticides are designed to produce acute cholinergic effects through inhibition of acetylcholinesterase (AChE) and some OP compounds can cause OP compound-induced delayed neurotoxicity (OPIDN) via chemical modification of neurotoxic esterase (neuropathy target esterase, NTE), this review focuses on the capacity of chlorpyrifos to precipitate these and other adverse neurological consequences. Chlorpyrifos 352-364 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 7531775-3 1995 Because chlorpyrifos and other OP insecticides are designed to produce acute cholinergic effects through inhibition of acetylcholinesterase (AChE) and some OP compounds can cause OP compound-induced delayed neurotoxicity (OPIDN) via chemical modification of neurotoxic esterase (neuropathy target esterase, NTE), this review focuses on the capacity of chlorpyrifos to precipitate these and other adverse neurological consequences. Chlorpyrifos 352-364 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 7531775-9 1995 In accord with the much greater inhibitory potency of chlorpyrifos oxon for AChE than for NTE, clinical reports and experimental studies indicate that OPIDN from acute exposures to chlorpyrifos requires doses well in excess of the LD50, even when followed by repeated doses of the OPIDN potentiator phenylmethanesulfonyl fluoride (PMSF). O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 54-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 7531775-9 1995 In accord with the much greater inhibitory potency of chlorpyrifos oxon for AChE than for NTE, clinical reports and experimental studies indicate that OPIDN from acute exposures to chlorpyrifos requires doses well in excess of the LD50, even when followed by repeated doses of the OPIDN potentiator phenylmethanesulfonyl fluoride (PMSF). Chlorpyrifos 54-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 7863507-0 1995 Inhibition of human acetylcholinesterase by cyclophosphamide. Cyclophosphamide 44-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 7863507-1 1995 The inhibitory effect of cyclophosphamide (CP) on human erythrocyte membrane bound acetylcholinesterase (AChE) was investigated in the present study. Cyclophosphamide 25-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 7863507-1 1995 The inhibitory effect of cyclophosphamide (CP) on human erythrocyte membrane bound acetylcholinesterase (AChE) was investigated in the present study. Cyclophosphamide 25-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 8853707-7 1995 These results demonstrate that the glutamate reuptake system has an important role in regulation of the responses to glutamate which is similar to that of acetylcholinesterase in regulation of responses to acetylcholine. Glutamic Acid 35-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-175 8853707-7 1995 These results demonstrate that the glutamate reuptake system has an important role in regulation of the responses to glutamate which is similar to that of acetylcholinesterase in regulation of responses to acetylcholine. Glutamic Acid 117-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-175 8750900-0 1995 Methantheline improves the reactivation by HI 6 of human erythrocyte acetylcholinesterase inhibited by soman in vitro. Methantheline 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 8750900-0 1995 Methantheline improves the reactivation by HI 6 of human erythrocyte acetylcholinesterase inhibited by soman in vitro. asoxime chloride 43-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 8750900-1 1995 The effect of methantheline, a quaternary ammonium compound, on the reactivation by HI 6 of soman-inhibited human erythrocyte acetylcholinesterase (AChE) was investigated in vitro using purified human erythrocyte AChE or washed human erythrocytes. Methantheline 14-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 8750900-1 1995 The effect of methantheline, a quaternary ammonium compound, on the reactivation by HI 6 of soman-inhibited human erythrocyte acetylcholinesterase (AChE) was investigated in vitro using purified human erythrocyte AChE or washed human erythrocytes. Methantheline 14-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 8750900-2 1995 Methantheline itself was found to be a mixed competitive/non-competitive inhibitor of AChE (Kii 360 +/- 70 mumol/l; Ki 240 +/- 10 mumol/l). Methantheline 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 8750900-4 1995 With HI 6 alone, the portion of AChE activity which could be reactivated 25 min after the start of ageing decreased rapidly with the delay of the oxime addition (100% of the original activity at immediate addition), the half-life being approximately 2.5 min. asoxime chloride 5-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 8750900-4 1995 With HI 6 alone, the portion of AChE activity which could be reactivated 25 min after the start of ageing decreased rapidly with the delay of the oxime addition (100% of the original activity at immediate addition), the half-life being approximately 2.5 min. Oximes 146-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 8750900-5 1995 With methantheline alone (0.36 mmol/l) the AChE activity was lower after immediate addition (37% of the original value), but the loss of activity due to the increasing delay of methantheline addition exhibited a similar half-life as with HI 6. Methantheline 5-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 8750900-6 1995 Finally, when methantheline (0.36 mmol/l) was added at the start of ageing and HI 6 at various intervals thereafter the half-life of AChE activity loss due to the delay of HI 6 addition at least doubled, compared to incubations without methantheline. Methantheline 14-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 8750900-6 1995 Finally, when methantheline (0.36 mmol/l) was added at the start of ageing and HI 6 at various intervals thereafter the half-life of AChE activity loss due to the delay of HI 6 addition at least doubled, compared to incubations without methantheline. Methantheline 236-249 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 7704991-0 1995 Inhibition of acetylcholinesterase selectively potentiates NG-monomethyl-L-arginine-resistant actions of acetylcholine in human forearm vasculature. omega-N-Methylarginine 59-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 7582849-0 1995 Activities of acetylcholinesterase and NA+, K+ -ATP-ase in human erythrocytes after ethanol consumption. Ethanol 84-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 7582849-1 1995 The influence of ethanol consumption on acetylcholinesterase (AchE) and Na+, K+ -ATP-ase activities was examined in 14 healthy volunteers after 30 minutes of ethanol treatment at a dose 0.6 g/kg of body weight. Ethanol 17-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 7582849-1 1995 The influence of ethanol consumption on acetylcholinesterase (AchE) and Na+, K+ -ATP-ase activities was examined in 14 healthy volunteers after 30 minutes of ethanol treatment at a dose 0.6 g/kg of body weight. Ethanol 17-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 7582849-4 1995 In vitro experiments showed that ethanol inhibited the AchE and N+, K+ -ATP-ase activities immediately and in proportion to the concentration of ethanol used. Ethanol 33-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 7582849-4 1995 In vitro experiments showed that ethanol inhibited the AchE and N+, K+ -ATP-ase activities immediately and in proportion to the concentration of ethanol used. Ethanol 145-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 7814634-2 1995 The characteristic form of AChE in the end-plate basal lamina has the catalytic subunits disulfide linked to a collagen-like tail unit. Disulfides 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 7542325-1 1995 The effect of the well known anticancer drug "cisplatin" on the human erythrocyte membrane-bound acetylcholinesterase (AChE) has been investigated. Cisplatin 46-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 7542325-2 1995 It was found that cisplatin has inhibitory activity against AChE. Cisplatin 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 7542325-3 1995 Cisplatin (0.5-7.0 mM) inhibited AChE activity (27-82%) in a concentration dependent manner. Cisplatin 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 7542325-4 1995 The nature of the inhibition of AChE by cisplatin was complex and involved a partial reversible stage followed by a slow acting irreversible step. Cisplatin 40-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 7542325-6 1995 By diluting the preincubated AChE-cisplatin mixture for different times (0-24 h), the inhibition was partially reversed but again increased progressively with incubation time, ultimately reaching complete inhibition. Cisplatin 34-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 7799993-5 1995 In one case, 66 h after intoxication with oxydemeton-S-methyl, the neuromuscular block worsened, indicating that aging of the AChE had been completed. oxydemeton-s-methyl 42-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 7799993-8 1995 In humans, the efficacy of oximes in AChE reactivation can be determined rapidly using electrophysiologic studies. Oximes 27-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 7494866-1 1995 The acetylcholine hydrolyzing enzyme, acetylcholinesterase, primarily functions in nerve conduction, yet it appears in several guises, due to tissue-specific expression, alternative mRNA splicing and variable aggregation modes. Acetylcholine 4-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 8548601-7 1995 A reversible inhibitor of acetylcholinesterase, tacrine, has been approved in the United States and other countries for the symptomatic treatment of mild to moderate AD, but its use still arises many questions. Tacrine 48-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 8570945-1 1995 The approval for marketing of tacrine (Cognex), an acetylcholinesterase inhibitor, allowed physicians and the general people to attract attention to a degenerative disease, which prevalence dramatically increases every year. Tacrine 30-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 8570945-1 1995 The approval for marketing of tacrine (Cognex), an acetylcholinesterase inhibitor, allowed physicians and the general people to attract attention to a degenerative disease, which prevalence dramatically increases every year. Tacrine 39-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 7891368-1 1994 Organophosphorus (OP) compounds can bind to and inactivate several target molecules other than acetylcholinesterase (AChE). organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 7891368-1 1994 Organophosphorus (OP) compounds can bind to and inactivate several target molecules other than acetylcholinesterase (AChE). organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 7891368-2 1994 In the present study, five sets of structurally related organophosphorus compounds were used to evaluate the relationships between organophosphorus binding sites of AChE, neuropathy target esterase (NTE), trypsin, and the target molecule(s) involved in inhibition of splenocyte activation by OP compounds. organophosphorus 56-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 7891368-2 1994 In the present study, five sets of structurally related organophosphorus compounds were used to evaluate the relationships between organophosphorus binding sites of AChE, neuropathy target esterase (NTE), trypsin, and the target molecule(s) involved in inhibition of splenocyte activation by OP compounds. organophosphorus 131-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 7738603-1 1994 We have performed docking studies with the SYSDOC program on acetylcholinesterase (AChE) to predict the binding sites in AChE of huperzine A (HA), which is a potent and selective, reversible inhibitor of AChE. huperzine A 129-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 7857974-10 1995 These polyclonal antibodies were affinity-purified and used in development of another two-site immunometric assay of COX-1 with CX-110-AChE as tracer. cx-110 128-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 7536306-5 1994 The acetylcholinesterase inhibitor, physostigmine, exerts a similar modulatory influence on the ACh current and on its extinction, and also prevents the manifestation of the effects of amiridin and tacrine. Physostigmine 36-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 7536306-5 1994 The acetylcholinesterase inhibitor, physostigmine, exerts a similar modulatory influence on the ACh current and on its extinction, and also prevents the manifestation of the effects of amiridin and tacrine. Acetylcholine 96-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 7536306-5 1994 The acetylcholinesterase inhibitor, physostigmine, exerts a similar modulatory influence on the ACh current and on its extinction, and also prevents the manifestation of the effects of amiridin and tacrine. amiridine 185-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 7536306-5 1994 The acetylcholinesterase inhibitor, physostigmine, exerts a similar modulatory influence on the ACh current and on its extinction, and also prevents the manifestation of the effects of amiridin and tacrine. Tacrine 198-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 7947960-0 1994 Sensitivity of acetylcholinesterase molecular forms to inhibition by high MgCl2 concentration. Magnesium Chloride 74-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 7947960-1 1994 Previous studies have shown that the asymmetric (A12) and the dimeric (G2), but not the tetrameric (G4), acetylcholinesterase (AChE) forms are inactivated by high MgCl2 concentration (Perelman and Inestrosa (1989) Anal. Magnesium Chloride 163-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 7947960-1 1994 Previous studies have shown that the asymmetric (A12) and the dimeric (G2), but not the tetrameric (G4), acetylcholinesterase (AChE) forms are inactivated by high MgCl2 concentration (Perelman and Inestrosa (1989) Anal. Magnesium Chloride 163-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 7947960-4 1994 Here we show that the effect of MgCl2 on AChE activity corresponds to an irreversible inhibition and is not due to environmental effects related to the different extraction media. Magnesium Chloride 32-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 7947960-7 1994 Purified AChE molecular forms showed the same sensitivity to MgCl2, than the same enzyme forms studied in tissue extracts. Magnesium Chloride 61-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 7826410-0 1994 [New acetylcholinesterase inhibitors--derivatives of vitamin B6]. Vitamin B 6 53-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-25 7826410-3 1994 Pyridoxamine derivatives are of interest in constructing new potent inhibitors of ACHE. Pyridoxamine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 7853361-0 1994 Choline derivatives and sodium fluoride protect acetylcholinesterase against irreversible inhibition and aging by DFP and paraoxon. Choline 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 7853361-0 1994 Choline derivatives and sodium fluoride protect acetylcholinesterase against irreversible inhibition and aging by DFP and paraoxon. Sodium Fluoride 24-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 7853361-1 1994 A light addressable potentiometric sensor was used to measure acetylcholinesterase (AChE) activity in order to evaluate the protective effects of quaternary compounds and NaF against enzyme phosphorylation and aging by two organophosphates. quaternary compounds 146-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 7853361-1 1994 A light addressable potentiometric sensor was used to measure acetylcholinesterase (AChE) activity in order to evaluate the protective effects of quaternary compounds and NaF against enzyme phosphorylation and aging by two organophosphates. Organophosphates 223-239 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 7853361-2 1994 The use of the immobilized AChE made possible the quick removal of reagents (i.e., organophosphate, 2-pralidoxime, and protectant), thereby permitting accurate determination of AChE activity before and after phosphorylation and aging. Organophosphates 83-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 7853361-2 1994 The use of the immobilized AChE made possible the quick removal of reagents (i.e., organophosphate, 2-pralidoxime, and protectant), thereby permitting accurate determination of AChE activity before and after phosphorylation and aging. 2-pralidoxime 100-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 7853361-3 1994 Paraoxon was 15-fold more potent in inhibiting AChE than DFP, while the percent aging following phosphorylation by diisopropylfluorophosphate (DFP) was much higher. Paraoxon 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 7853361-4 1994 Sodium fluoride (NaF), the most effective protectant against phosphorylation and aging, and the quaternary ammonium compounds reduced significantly AChE inhibition by DFP and paraoxon, to similar degrees. Quaternary Ammonium Compounds 96-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 7853361-4 1994 Sodium fluoride (NaF), the most effective protectant against phosphorylation and aging, and the quaternary ammonium compounds reduced significantly AChE inhibition by DFP and paraoxon, to similar degrees. Isoflurophate 167-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 7853361-4 1994 Sodium fluoride (NaF), the most effective protectant against phosphorylation and aging, and the quaternary ammonium compounds reduced significantly AChE inhibition by DFP and paraoxon, to similar degrees. Paraoxon 175-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 7853361-7 1994 The finding that quaternary ammonium compounds protect against phosphorylation is consonant with the proposed presence of the active site of AChE in an aromatic gorge. Quaternary Ammonium Compounds 17-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 7812033-11 1994 Based upon these results we suggest that the enteric neurons of the porcine small intestine can be subdivided into AchE-NADHd and NADPHd subpopulations. nadhd 120-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 7812033-12 1994 Since the latter colocalizes with the neuronal NO synthase enzyme, we further suggest a subdivision of the enteric nerve cells into AchE-NADHd and NOS-NADHd neurons. nadhd 137-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 8077224-10 1994 Taken together, these results indicate (alpha) that sub-unit dimerization mediated by the COOH-terminal cysteine of HuAChE can reverse the signal-mediated retention by masking recognition of KDEL by its cognate receptor and (b) that the native sequences of the acetylcholinesterase subunit polypeptide do not appear to function as a coupled retention/dimerization signal in the control of secretion of assembled enzyme molecules. Cysteine 104-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 261-281 8058733-0 1994 Antisense oligonucleotide inhibition of acetylcholinesterase gene expression induces progenitor cell expansion and suppresses hematopoietic apoptosis ex vivo. Oligonucleotides 10-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 8058733-5 1994 These oligonucleotide-triggered effects underlay considerable alterations at the cellular level: AS-ACHE but not S-ACHE increased cell counts, reflecting enhanced proliferation. Oligonucleotides 6-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 8053896-1 1994 Multiple binding sites for inhibitory choline esters in spontaneous decarbamoylation of dimethylcarbamoyl-acetylcholinesterase (AChE) were suggested from a wide range of IC50 values, in contrast with a limited range of AC50 values (concentration giving 50% of maximal activation) at a peripheral activatory site. choline esters 38-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-126 8053896-1 1994 Multiple binding sites for inhibitory choline esters in spontaneous decarbamoylation of dimethylcarbamoyl-acetylcholinesterase (AChE) were suggested from a wide range of IC50 values, in contrast with a limited range of AC50 values (concentration giving 50% of maximal activation) at a peripheral activatory site. choline esters 38-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 7927563-0 1994 Interaction of organophosphorus insecticides phosphamidon & malathion on lipid profile & acetylcholinesterase activity in human erythrocyte membrane. organophosphorus 15-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 7927563-0 1994 Interaction of organophosphorus insecticides phosphamidon & malathion on lipid profile & acetylcholinesterase activity in human erythrocyte membrane. Phosphamidon 45-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 7927563-0 1994 Interaction of organophosphorus insecticides phosphamidon & malathion on lipid profile & acetylcholinesterase activity in human erythrocyte membrane. Adenosine Monophosphate 59-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 7927563-0 1994 Interaction of organophosphorus insecticides phosphamidon & malathion on lipid profile & acetylcholinesterase activity in human erythrocyte membrane. Malathion 64-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 7927563-0 1994 Interaction of organophosphorus insecticides phosphamidon & malathion on lipid profile & acetylcholinesterase activity in human erythrocyte membrane. Adenosine Monophosphate 92-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 7927563-1 1994 The organophosphorus insecticides phosphamidon and malathion were found to inhibit the activity of human acetylcholinesterase in vitro, in the human erythrocyte membrane. organophosphorus 4-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 7927563-1 1994 The organophosphorus insecticides phosphamidon and malathion were found to inhibit the activity of human acetylcholinesterase in vitro, in the human erythrocyte membrane. Phosphamidon 34-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 7927563-1 1994 The organophosphorus insecticides phosphamidon and malathion were found to inhibit the activity of human acetylcholinesterase in vitro, in the human erythrocyte membrane. Malathion 51-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 7888726-5 1994 Preparative purification by affinity chromatography showed a better AChE yield with the use of procainamide as a ligand, vis-a-vis acridinium. Procainamide 95-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 7888726-6 1994 Maximum recovery for CSF and caudate nucleus AChE was 10 and 43% using acridinium and procainamide, respectively. acridinium I 71-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 7888726-6 1994 Maximum recovery for CSF and caudate nucleus AChE was 10 and 43% using acridinium and procainamide, respectively. Procainamide 86-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 7888726-7 1994 Qualitative analysis by SDS-PAGE of affinity-purified AChE revealed four major bands between 50 and 62 kDa, corresponding to the catalytic subunits of AChE as verified by an anti-AChE polyclonal antibody. Sodium Dodecyl Sulfate 24-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 7888726-7 1994 Qualitative analysis by SDS-PAGE of affinity-purified AChE revealed four major bands between 50 and 62 kDa, corresponding to the catalytic subunits of AChE as verified by an anti-AChE polyclonal antibody. Sodium Dodecyl Sulfate 24-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 7888726-7 1994 Qualitative analysis by SDS-PAGE of affinity-purified AChE revealed four major bands between 50 and 62 kDa, corresponding to the catalytic subunits of AChE as verified by an anti-AChE polyclonal antibody. Sodium Dodecyl Sulfate 24-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 7848798-5 1994 Tacrine, a drug that inhibits acetylcholinesterase, has proved to have a cognitive-enhancing effect, but this is limited in time and the drug has side-effects. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 7866482-5 1994 Tetrahydroaminoacridine (THA, tacrine) is a centrally active reversible acetylcholinesterase inhibitor. Tacrine 0-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 7866482-5 1994 Tetrahydroaminoacridine (THA, tacrine) is a centrally active reversible acetylcholinesterase inhibitor. Tacrine 25-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 7866482-5 1994 Tetrahydroaminoacridine (THA, tacrine) is a centrally active reversible acetylcholinesterase inhibitor. Tacrine 30-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 7962068-3 1994 Next, we determined the influence of nerve-evoked activity vs putative trophic factors on the synaptic accumulation of AChE mRNA levels in muscle fibers paralyzed by either surgical denervation or selective blockage of nerve action potentials with chronic superfusion of tetrodotoxin. Tetrodotoxin 271-283 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 7965073-6 1994 However, we have made two observations that are surprising in light of our knowledge concerning the vertebrate neuromuscular junction where released ACh is rapidly hydrolyzed by acetylcholinesterase (AChE) to choline, which is then taken up by a high-affinity uptake system. Acetylcholine 149-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-198 7965073-6 1994 However, we have made two observations that are surprising in light of our knowledge concerning the vertebrate neuromuscular junction where released ACh is rapidly hydrolyzed by acetylcholinesterase (AChE) to choline, which is then taken up by a high-affinity uptake system. Acetylcholine 149-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-204 7965073-6 1994 However, we have made two observations that are surprising in light of our knowledge concerning the vertebrate neuromuscular junction where released ACh is rapidly hydrolyzed by acetylcholinesterase (AChE) to choline, which is then taken up by a high-affinity uptake system. Choline 184-191 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-204 7966438-4 1994 The primary acute mammalian toxicity associated with exposure to organophosphorus pesticides results from inhibition of the enzyme acetylcholinesterase. organophosphorus 65-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-151 8093024-5 1994 Immunoblotting of SDS-reduced AChE showed binding of the four mAbs with "soluble" caudate nucleus and FBS AChE, but not with erythrocyte AChE. Sodium Dodecyl Sulfate 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 8093024-5 1994 Immunoblotting of SDS-reduced AChE showed binding of the four mAbs with "soluble" caudate nucleus and FBS AChE, but not with erythrocyte AChE. Sodium Dodecyl Sulfate 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 8093024-5 1994 Immunoblotting of SDS-reduced AChE showed binding of the four mAbs with "soluble" caudate nucleus and FBS AChE, but not with erythrocyte AChE. Sodium Dodecyl Sulfate 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 7827330-0 1994 Activation of acetylcholinesterase by aluminium(III): the relevance of the metal species. ALUMINUM ION 38-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 7827330-0 1994 Activation of acetylcholinesterase by aluminium(III): the relevance of the metal species. Metals 75-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 7827330-1 1994 The present paper reports how aluminium [Al(III)] at a concentration of 3.7 microM can activate the bovine erythrocytic enzyme acetylcholinesterase (AChE) by about 38% in vitro. Aluminum 30-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 7827330-1 1994 The present paper reports how aluminium [Al(III)] at a concentration of 3.7 microM can activate the bovine erythrocytic enzyme acetylcholinesterase (AChE) by about 38% in vitro. al(iii) 41-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 7827330-3 1994 The interaction between Al3+ and gamma-peripheral sites of the enzyme produces AChE structural modifications as evidenced by circular dichroism measurements. ALUMINUM ION 24-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 7738603-1 1994 We have performed docking studies with the SYSDOC program on acetylcholinesterase (AChE) to predict the binding sites in AChE of huperzine A (HA), which is a potent and selective, reversible inhibitor of AChE. huperzine A 129-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 7738603-1 1994 We have performed docking studies with the SYSDOC program on acetylcholinesterase (AChE) to predict the binding sites in AChE of huperzine A (HA), which is a potent and selective, reversible inhibitor of AChE. huperzine A 129-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 7738604-0 1994 Prediction of the binding site of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine in acetylcholinesterase by docking studies with the SYSDOC program. Donepezil 34-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 7738604-1 1994 In the preceding paper we reported on a docking study with the SYSDOC program for predicting the binding sites of huperzine A in acetylcholinesterase (AChE) [Pang, Y.-P. and Kozikowski, A.P., J. Comput.-Aided Mol. huperzine A 114-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-149 7738604-1 1994 In the preceding paper we reported on a docking study with the SYSDOC program for predicting the binding sites of huperzine A in acetylcholinesterase (AChE) [Pang, Y.-P. and Kozikowski, A.P., J. Comput.-Aided Mol. huperzine A 114-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 7738604-3 1994 Here we present a prediction of the binding sites of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine (E2020) in AChE by the same method. Donepezil 53-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 7738604-3 1994 Here we present a prediction of the binding sites of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine (E2020) in AChE by the same method. Donepezil 114-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 8028515-2 1994 Pyridostigmine (PD), an acetylcholinesterase inhibitor, elicits GH secretion when administered alone and enhances the GH response to GHRH in normal subjects. Pyridostigmine Bromide 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 7951067-1 1994 Acetylcholinesterase (AChE) activity, as a function of time, showed a concentration dependent increase induced by NaCl, followed by a plateau. Sodium Chloride 114-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 7970904-6 1994 Dose-response curves to locally applied Ach were obtained before and after the intravenous administration of the AChE inhibitor physostigmine (Phys). Physostigmine 128-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 7937562-1 1994 2,3-Butanedione monoxime, also known as diacetyl monoxime, is a nucleophilic agent which dephosphorylates acetylcholinesterase poisoned with organophosphates. diacetylmonoxime 0-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 7937562-1 1994 2,3-Butanedione monoxime, also known as diacetyl monoxime, is a nucleophilic agent which dephosphorylates acetylcholinesterase poisoned with organophosphates. diacetylmonoxime 40-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 7937562-1 1994 2,3-Butanedione monoxime, also known as diacetyl monoxime, is a nucleophilic agent which dephosphorylates acetylcholinesterase poisoned with organophosphates. Organophosphates 141-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 8023345-6 1994 We conclude that in addition to AChE, voltage-gated Ca2+ channels and nicotinic receptors are possible sites of action of organophosphates in mammalian systems. Organophosphates 122-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 7951067-1 1994 Acetylcholinesterase (AChE) activity, as a function of time, showed a concentration dependent increase induced by NaCl, followed by a plateau. Sodium Chloride 114-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 8023345-2 1994 However, subacute exposure of humans to organophosphates induces cognitive and emotional defects which might not solely be attributable to AChE inhibition. Organophosphates 40-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 7951067-3 1994 Sucrose increased the initial rise and the final value of AChE activity and caused no changes, as a function of time, in the absence of cations. Sucrose 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 7951067-4 1994 Moreover sucrose eliminated AChE activity decrease caused by LiCl. Sucrose 9-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 7951067-4 1994 Moreover sucrose eliminated AChE activity decrease caused by LiCl. Lithium Chloride 61-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 7951067-5 1994 2-mercaptoethanol induced considerable and steady increase of AChE activity, in the presence or absence of cations or sucrose and no changes, as a function of time. Mercaptoethanol 0-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 7951067-6 1994 These results show an activating and protecting effect of sucrose on AChE and the possible involvement of sulfhydryl (SH) groups in the time-dependent changes of the enzyme activity induced by Na+ or Li+. Sucrose 58-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 8180397-2 1994 Wild-type acetylcholinesterase, YT1, has histidine at codon 322, whereas the genetic variant of acetylcholinesterase, YT2, has asparagine. Histidine 41-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-30 8180397-2 1994 Wild-type acetylcholinesterase, YT1, has histidine at codon 322, whereas the genetic variant of acetylcholinesterase, YT2, has asparagine. Asparagine 127-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 8185877-5 1994 Physostigmine plasma concentrations were relatively stable (0.56 +/- 0.10 ng/ml) and correlated well with blood acetylcholinesterase inhibition. Physostigmine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 8134223-5 1994 (2) Laboratory study: The direct effect of obidoxime and of pralidoxime on acetylcholinesterase activity in vitro was investigated in normal human packed red blood cells pretreated with an organophosphate (paraoxon) or a carbamate (aldicarb or methomyl). Obidoxime Chloride 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 8736043-4 1994 Pyridostigmine, the acetylcholinesterase inhibitor, increases cholinergic tone, inhibits SS release and increases the release of GH. Pyridostigmine Bromide 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 8134223-5 1994 (2) Laboratory study: The direct effect of obidoxime and of pralidoxime on acetylcholinesterase activity in vitro was investigated in normal human packed red blood cells pretreated with an organophosphate (paraoxon) or a carbamate (aldicarb or methomyl). pralidoxime 60-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 8134223-5 1994 (2) Laboratory study: The direct effect of obidoxime and of pralidoxime on acetylcholinesterase activity in vitro was investigated in normal human packed red blood cells pretreated with an organophosphate (paraoxon) or a carbamate (aldicarb or methomyl). Organophosphates 189-204 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 8134223-5 1994 (2) Laboratory study: The direct effect of obidoxime and of pralidoxime on acetylcholinesterase activity in vitro was investigated in normal human packed red blood cells pretreated with an organophosphate (paraoxon) or a carbamate (aldicarb or methomyl). Carbamates 221-230 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 8134223-13 1994 In vitro, oximes reactivated acetylcholinesterase inhibited with paraoxon, whereas no significant effect of oximes on carbamylated enzyme activity was observed. Oximes 10-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 8134223-13 1994 In vitro, oximes reactivated acetylcholinesterase inhibited with paraoxon, whereas no significant effect of oximes on carbamylated enzyme activity was observed. Paraoxon 65-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 27520522-1 1994 Velnacrine is an hydroxylated derivative of the acetylcholinesterase inhibitor tacrine. velnacrine 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 8122110-3 1994 A molecular dynamics simulation of acetylcholinesterase in water reveals the transient opening of a short channel, large enough to pass a water molecule, through a thin wall of the active site near tryptophan-84. Water 59-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 8122110-3 1994 A molecular dynamics simulation of acetylcholinesterase in water reveals the transient opening of a short channel, large enough to pass a water molecule, through a thin wall of the active site near tryptophan-84. Water 138-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 8122110-3 1994 A molecular dynamics simulation of acetylcholinesterase in water reveals the transient opening of a short channel, large enough to pass a water molecule, through a thin wall of the active site near tryptophan-84. Tryptophan 198-208 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 27520522-1 1994 Velnacrine is an hydroxylated derivative of the acetylcholinesterase inhibitor tacrine. Tacrine 79-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 8126750-2 1994 The patient was exposed to an insecticide mixture containing phosphorothiate, pyrethrin, piperonyl butoxide, and petroleum distillates, which produced symptoms consistent with acute acetylcholinesterase inhibitor poisoning as well as an upper respiratory tract irritant. phosphorothiate 61-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-202 8027504-2 1994 The reactions between the enzyme acetylcholinesterase (AChE), its natural substrate, ACh, and the various types of inhibitors are described. Acetylcholine 55-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 8195795-2 1994 The acetylcholine-related enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were measured in plasma, erythrocytes, platelets and lymphocytes. Acetylcholine 4-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 8145739-0 1994 Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase. Tyrosine 8-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 8145739-0 1994 Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase. huperzine A 39-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 8126750-2 1994 The patient was exposed to an insecticide mixture containing phosphorothiate, pyrethrin, piperonyl butoxide, and petroleum distillates, which produced symptoms consistent with acute acetylcholinesterase inhibitor poisoning as well as an upper respiratory tract irritant. Piperonyl Butoxide 89-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-202 8306998-5 1994 97% of AChE was extractable in low-salt and high-salt detergent-free buffers, and only 3% was solubilised by a further extraction in the presence of Triton X-100. Salts 35-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 7-11 8117296-6 1994 These data show that oxygen radical treatment converts acetylcholinesterase to a partially unfolded state, which retains most of its secondary structure but lacks substantial tertiary structure, thus resembling a "molten globule" state. Oxygen 21-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 8306998-9 1994 In low-salt-soluble and high-salt-soluble extracts, AChE was solubilised as a hydrophilic globular form, probably a dimeric G2. Salts 29-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 8306998-10 1994 The analysis of diisopropylfluorophosphate-labelled extracts by SDS/PAGE, and unlabelled extracts by immunoblotting using a polyvalent antiserum to N. americanus AChE, indicated that the AChE isolated in each extract was biochemically and immunologically similar. Isoflurophate 16-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 8306998-11 1994 The banding patterns obtained were comparable to that seen when purified AChE was analysed by SDS/PAGE and immunoblotted. Sodium Dodecyl Sulfate 94-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 8306998-5 1994 97% of AChE was extractable in low-salt and high-salt detergent-free buffers, and only 3% was solubilised by a further extraction in the presence of Triton X-100. Salts 49-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 7-11 8306998-6 1994 AChE in all three extracts was affected by the AChE inhibitors eserine, bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide and edrophonium chloride, but was resistant to the effects of tetramonoisopropylpyrophosphortetramide, a butyrylcholinesterase inhibitor. bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide 72-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 8306998-6 1994 AChE in all three extracts was affected by the AChE inhibitors eserine, bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide and edrophonium chloride, but was resistant to the effects of tetramonoisopropylpyrophosphortetramide, a butyrylcholinesterase inhibitor. Edrophonium 133-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 8306998-6 1994 AChE in all three extracts was affected by the AChE inhibitors eserine, bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide and edrophonium chloride, but was resistant to the effects of tetramonoisopropylpyrophosphortetramide, a butyrylcholinesterase inhibitor. tetramonoisopropylpyrophosphortetramide 191-230 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 8306998-7 1994 Sucrose density centrifugation revealed that AChE in all somatic extracts (low-salt, high-salt and detergent) resolved almost exclusively as a single peak between 6.9-7.5 S, while excretory/secretory products resolved at 8.2 S. These values are all compatible with dimers of catalytic subunits and no evidence was found for the presence of higher oligomers such as asymmetric forms. Sucrose 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 8306998-7 1994 Sucrose density centrifugation revealed that AChE in all somatic extracts (low-salt, high-salt and detergent) resolved almost exclusively as a single peak between 6.9-7.5 S, while excretory/secretory products resolved at 8.2 S. These values are all compatible with dimers of catalytic subunits and no evidence was found for the presence of higher oligomers such as asymmetric forms. Salts 79-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 8306998-7 1994 Sucrose density centrifugation revealed that AChE in all somatic extracts (low-salt, high-salt and detergent) resolved almost exclusively as a single peak between 6.9-7.5 S, while excretory/secretory products resolved at 8.2 S. These values are all compatible with dimers of catalytic subunits and no evidence was found for the presence of higher oligomers such as asymmetric forms. Salts 90-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 8306998-9 1994 In low-salt-soluble and high-salt-soluble extracts, AChE was solubilised as a hydrophilic globular form, probably a dimeric G2. Salts 7-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 7857205-0 1994 In vitro oxime-induced reactivation of various molecular forms of soman-inhibited acetylcholinesterase in striated muscle from rat, monkey and human. Oximes 9-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 7857205-1 1994 The purpose of this study was to compare the in vitro reactivation of the various molecular forms of soman-inhibited acetylcholinesterase by oximes such as HI-6, toxogonin and PAM, in striated muscle tissue from three species-rat, monkey and human. asoxime chloride 156-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 7857205-3 1994 In the Pre-Post mode the oxime effects would result from a combination of not only shielding of acetylcholinesterase from soman inhibition but also from immediate reactivation of soman-inhibited acetylcholinesterase. Oximes 25-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 7857205-3 1994 In the Pre-Post mode the oxime effects would result from a combination of not only shielding of acetylcholinesterase from soman inhibition but also from immediate reactivation of soman-inhibited acetylcholinesterase. Oximes 25-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-215 7857205-5 1994 HI-6 (Pre-Post) increased significantly the activity of soman-inhibited acetylcholinesterase in the rat, human and monkey muscle. asoxime chloride 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 7857205-9 1994 Effectiveness of oxime-induced reactivation of soman-inhibited acetylcholinesterase could be estimated from the total acetylcholinesterase activity which appears to reflect the results found with the individual molecular forms of acetylcholinesterase. Oximes 17-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 7857205-9 1994 Effectiveness of oxime-induced reactivation of soman-inhibited acetylcholinesterase could be estimated from the total acetylcholinesterase activity which appears to reflect the results found with the individual molecular forms of acetylcholinesterase. Oximes 17-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 7857205-9 1994 Effectiveness of oxime-induced reactivation of soman-inhibited acetylcholinesterase could be estimated from the total acetylcholinesterase activity which appears to reflect the results found with the individual molecular forms of acetylcholinesterase. Oximes 17-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 7857205-10 1994 In addition, SAD-128, a non-oxime bispyridinium compound, appeared to enhance significantly the HI-6 induced reactivation of soman-inhibited acetylcholinesterase in human but not rat striated muscle. asoxime chloride 96-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 7884403-1 1994 The pharmacological and clinical properties of a novel phenyl carbamate acetylcholinesterase (AChE) inhibitor, SDZ ENA 713 are described. Rivastigmine 111-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 8306487-2 1994 Pyridostigmine, the acetylcholinesterase inhibitor, releases GH by this mechanism. Pyridostigmine Bromide 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 7884403-3 1994 SDZ ENA 713 produced a 10-fold greater inhibition of AChE in the hippocampus and cortex than in the heart and skeletal muscle, which explains its relatively low toxicity and freedom from cholinergic side effects. ENA 4-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 8302283-16 1994 Two parallel plane acridine araphanes are pure uncompetitive inhibitors of AChE. acridine araphanes 19-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 8264551-3 1993 Present results show that AE-2 decreases the rate of inhibition of FBS AChE by the positively charged organophosphate amiton-p-toluene sulfonate and the positively charged carbamates pyridostigmine and neostigmine but accelerates inhibition of FBS AChE by the neutral organophosphates paraoxon and diisopropylfluorophosphate. Neostigmine 202-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 8186246-5 1994 In conclusion, our experimental data indicate that TS and CS are potent inhibitors of AChE activity and significantly potentiate the anticholinesterase activity of THA. cholesteryl succinate 58-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 8186246-6 1994 Such potent and synergistic inhibition of AChE suggest that TS or CS, alone and in combination with THA, may prove beneficial in the treatment of organophosphate poisoning and Alzheimer"s disease. cholesteryl succinate 66-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 8186246-6 1994 Such potent and synergistic inhibition of AChE suggest that TS or CS, alone and in combination with THA, may prove beneficial in the treatment of organophosphate poisoning and Alzheimer"s disease. Tacrine 100-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 8186246-6 1994 Such potent and synergistic inhibition of AChE suggest that TS or CS, alone and in combination with THA, may prove beneficial in the treatment of organophosphate poisoning and Alzheimer"s disease. Organophosphates 146-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 8257680-4 1993 The OP-bound pinacolyl moiety of soman-inhibited and aged AChE was detached completely, whereas only partial dealkylation of the pinacolyl group was observed for soman-inhibited BChEs. pinacolyl 13-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 8257680-10 1993 The broadening of the 31P NMR signal of native OP-ChEs relative to that of OP-Cht is in agreement with the crystal structure of AChE, showing that the active site region of ChEs in solution resides in a deep, narrow gorge. ET bromodomain inhibitor 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 8257680-10 1993 The broadening of the 31P NMR signal of native OP-ChEs relative to that of OP-Cht is in agreement with the crystal structure of AChE, showing that the active site region of ChEs in solution resides in a deep, narrow gorge. 2-(N-cyclohexylamino)ethanesulfonic acid 50-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 8136015-5 1993 AChE was marginally protected from thermal inactivation by the "nonspecific salts" ammonium sulfate and sodium chloride and to a greater extent by the "active site-specific salts" choline chloride, sodium acetate, and acetylcholine iodide. Ammonium Sulfate 83-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 8136015-5 1993 AChE was marginally protected from thermal inactivation by the "nonspecific salts" ammonium sulfate and sodium chloride and to a greater extent by the "active site-specific salts" choline chloride, sodium acetate, and acetylcholine iodide. Sodium Chloride 104-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 8136015-5 1993 AChE was marginally protected from thermal inactivation by the "nonspecific salts" ammonium sulfate and sodium chloride and to a greater extent by the "active site-specific salts" choline chloride, sodium acetate, and acetylcholine iodide. Choline 180-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 8136015-5 1993 AChE was marginally protected from thermal inactivation by the "nonspecific salts" ammonium sulfate and sodium chloride and to a greater extent by the "active site-specific salts" choline chloride, sodium acetate, and acetylcholine iodide. Sodium Acetate 198-212 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 8136015-5 1993 AChE was marginally protected from thermal inactivation by the "nonspecific salts" ammonium sulfate and sodium chloride and to a greater extent by the "active site-specific salts" choline chloride, sodium acetate, and acetylcholine iodide. Acetylcholine 218-238 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 8136015-7 1993 This data supports the hypothesis that thermal inactivation of AChE occurs by conformational scrambling and that aromatic amino acid residue(s) are involved in this process. Amino Acids, Aromatic 113-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 8264551-2 1993 AE-2 partially inhibited the rate of hydrolysis of the charged substrate acetylthiocholine by FBS AChE, whereas it increased the rate of hydrolysis of the neutral substrate indophenyl acetate. Acetylthiocholine 73-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 8264551-3 1993 Present results show that AE-2 decreases the rate of inhibition of FBS AChE by the positively charged organophosphate amiton-p-toluene sulfonate and the positively charged carbamates pyridostigmine and neostigmine but accelerates inhibition of FBS AChE by the neutral organophosphates paraoxon and diisopropylfluorophosphate. organophosphate amiton-p-toluene sulfonate 102-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 8264551-3 1993 Present results show that AE-2 decreases the rate of inhibition of FBS AChE by the positively charged organophosphate amiton-p-toluene sulfonate and the positively charged carbamates pyridostigmine and neostigmine but accelerates inhibition of FBS AChE by the neutral organophosphates paraoxon and diisopropylfluorophosphate. Organophosphates 268-284 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 8264551-3 1993 Present results show that AE-2 decreases the rate of inhibition of FBS AChE by the positively charged organophosphate amiton-p-toluene sulfonate and the positively charged carbamates pyridostigmine and neostigmine but accelerates inhibition of FBS AChE by the neutral organophosphates paraoxon and diisopropylfluorophosphate. Paraoxon 285-293 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 8264551-3 1993 Present results show that AE-2 decreases the rate of inhibition of FBS AChE by the positively charged organophosphate amiton-p-toluene sulfonate and the positively charged carbamates pyridostigmine and neostigmine but accelerates inhibition of FBS AChE by the neutral organophosphates paraoxon and diisopropylfluorophosphate. Isoflurophate 298-324 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 8360678-1 1993 Cercopithecus monkey brain acetylcholinesterase (AChE; EC 3.1.1.7) consists of about 15% hydrophilic, salt-soluble enzyme and 83% amphiphilic, detergent-soluble enzyme. Salts 102-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 8297012-1 1993 Choline (Ch) and acetylcholine (Ach) microenzyme sensors were developed based on the immobilization of choline oxidase (ChO) and acetylcholinesterase (AchE) at the tip of a 25-micron Pt wire sealed in glass. Choline 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 8297012-1 1993 Choline (Ch) and acetylcholine (Ach) microenzyme sensors were developed based on the immobilization of choline oxidase (ChO) and acetylcholinesterase (AchE) at the tip of a 25-micron Pt wire sealed in glass. Choline 0-2 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 8297012-1 1993 Choline (Ch) and acetylcholine (Ach) microenzyme sensors were developed based on the immobilization of choline oxidase (ChO) and acetylcholinesterase (AchE) at the tip of a 25-micron Pt wire sealed in glass. Acetylcholine 17-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 8297012-1 1993 Choline (Ch) and acetylcholine (Ach) microenzyme sensors were developed based on the immobilization of choline oxidase (ChO) and acetylcholinesterase (AchE) at the tip of a 25-micron Pt wire sealed in glass. Acetylcholine 32-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 8224608-1 1993 Cholinesterases (acetylcholinesterase and butyrylcholinesterase) exhibit additional catalytic activities apart from their well-known action in hydrolyzing choline esters. Esters 163-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 8217881-4 1993 The enzymatic tracer was obtained by coupling the 3(O-carboxymethyl)oxime derivative to acetylcholinesterase (E.C.3.1.1.7.). 3(o-carboxymethyl)oxime 50-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 8136033-1 1993 Acetylcholinesterase from human caudate nucleus and partial thalamus was purified by using Con A-Sepharose, short-arm and long-arm ligand Sepharose affinity chromatographies. Sepharose 97-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 8136033-1 1993 Acetylcholinesterase from human caudate nucleus and partial thalamus was purified by using Con A-Sepharose, short-arm and long-arm ligand Sepharose affinity chromatographies. Sepharose 138-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 8136033-2 1993 SDS-PAGE of the purified AChE under the reduced condition showed one main band, corresponding to a molecular weight of 66 kD. Sodium Dodecyl Sulfate 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 8136033-6 1993 Con A-Sepharose affinity chromatography retained most of the applied AChE activity implying that the enzyme is a kind of glycoprotein. Sepharose 6-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 8302294-0 1993 Acetylcholinesterase inhibition by 1-methyl-4-phenylpyridinium ion, a bioactivated metabolite of MPTP. 1-Methyl-4-phenylpyridinium 35-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 8302294-0 1993 Acetylcholinesterase inhibition by 1-methyl-4-phenylpyridinium ion, a bioactivated metabolite of MPTP. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 97-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 8302294-1 1993 The effect of the neurotoxicant, 1-methyl-4-phenylpyridinium ion (MPP+) on acetylcholinesterase (AchE) activity was investigated. 1-Methyl-4-phenylpyridinium 33-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 8302294-1 1993 The effect of the neurotoxicant, 1-methyl-4-phenylpyridinium ion (MPP+) on acetylcholinesterase (AchE) activity was investigated. 1-Methyl-4-phenylpyridinium 33-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 8302294-1 1993 The effect of the neurotoxicant, 1-methyl-4-phenylpyridinium ion (MPP+) on acetylcholinesterase (AchE) activity was investigated. mangion-purified polysaccharide (Candida albicans) 66-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 8302294-1 1993 The effect of the neurotoxicant, 1-methyl-4-phenylpyridinium ion (MPP+) on acetylcholinesterase (AchE) activity was investigated. mangion-purified polysaccharide (Candida albicans) 66-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 8302294-3 1993 The kinetic parameter, Km for the substrate (acetylthiocholine), was found to be 0.216 mM and Ki for MPP+ for the inactivation of AChE was found to be 0.197 mM. Acetylthiocholine 45-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 8302294-3 1993 The kinetic parameter, Km for the substrate (acetylthiocholine), was found to be 0.216 mM and Ki for MPP+ for the inactivation of AChE was found to be 0.197 mM. mangion-purified polysaccharide (Candida albicans) 101-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 8302294-8 1993 It appears likely that the nigrostriatal toxicity by MPP+ leading to Parkinson"s disease-like syndrome may, in part, be mediated via the AChE inactivation. mangion-purified polysaccharide (Candida albicans) 53-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 8360678-1 1993 Cercopithecus monkey brain acetylcholinesterase (AChE; EC 3.1.1.7) consists of about 15% hydrophilic, salt-soluble enzyme and 83% amphiphilic, detergent-soluble enzyme. Salts 102-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 8360678-2 1993 Sucrose density gradient centrifugation showed that hydrophilic, salt-soluble AChE was composed of about 85% tetramer (10.3S) and 15% monomer (3.3S). Sucrose 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 8360678-2 1993 Sucrose density gradient centrifugation showed that hydrophilic, salt-soluble AChE was composed of about 85% tetramer (10.3S) and 15% monomer (3.3S). Salts 65-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 8360678-6 1993 It is shown that in tetrameric AChE, not all of the subunits are disulfide-bonded and that two populations of tetramers exist, one carrying one and the other carrying two hydrophobic anchors. Disulfides 65-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 8349597-2 1993 Substrate specificity determinants of human acetylcholinesterase (HuAChE) were identified by combination of molecular modeling and kinetic studies with enzymes mutated in residues Trp-86, Trp-286, Phe-295, Phe-297, Tyr-337, and Phe-338. Tryptophan 180-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 8349597-2 1993 Substrate specificity determinants of human acetylcholinesterase (HuAChE) were identified by combination of molecular modeling and kinetic studies with enzymes mutated in residues Trp-86, Trp-286, Phe-295, Phe-297, Tyr-337, and Phe-338. Tryptophan 188-191 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 8349597-2 1993 Substrate specificity determinants of human acetylcholinesterase (HuAChE) were identified by combination of molecular modeling and kinetic studies with enzymes mutated in residues Trp-86, Trp-286, Phe-295, Phe-297, Tyr-337, and Phe-338. Phenylalanine 197-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 8349597-2 1993 Substrate specificity determinants of human acetylcholinesterase (HuAChE) were identified by combination of molecular modeling and kinetic studies with enzymes mutated in residues Trp-86, Trp-286, Phe-295, Phe-297, Tyr-337, and Phe-338. Phenylalanine 206-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 8349597-2 1993 Substrate specificity determinants of human acetylcholinesterase (HuAChE) were identified by combination of molecular modeling and kinetic studies with enzymes mutated in residues Trp-86, Trp-286, Phe-295, Phe-297, Tyr-337, and Phe-338. Tyrosine 215-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 8349597-2 1993 Substrate specificity determinants of human acetylcholinesterase (HuAChE) were identified by combination of molecular modeling and kinetic studies with enzymes mutated in residues Trp-86, Trp-286, Phe-295, Phe-297, Tyr-337, and Phe-338. Phenylalanine 206-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 8411269-5 1993 Analysis of the enzyme activity retained by the phenyl-agarose showed that G1 AChE constituted the bulk of the amphiphilic molecules released without detergent. phenyl-sepharose 48-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 8411269-7 1993 Eighty and 45% of the AChE and BuChE activities in S2 were measured in the detergent-rich phase by Triton X-114 phase partitioning. Nonidet P-40 99-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 8372338-6 1993 The results obtained with neurotransmitter replacement therapy, e.g. with the acetylcholinesterase inhibitor tacrine, have generally been disappointing, even if a small clinical improvement has been observed in a few selected patients. Tacrine 109-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 7688303-3 1993 These mAb reacted with native as well as heat-denatured and SDS-denatured DS-AChE, indicating that the epitopes to which mAb bound are continuous determinants. Sodium Dodecyl Sulfate 60-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 7688303-7 1993 After reduction of brain DS-AChE by dithiothreitol, the mAb no longer reacted with the antigen, indicating that a disulfide bridge is important for the epitope. Dithiothreitol 36-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 7688303-7 1993 After reduction of brain DS-AChE by dithiothreitol, the mAb no longer reacted with the antigen, indicating that a disulfide bridge is important for the epitope. Disulfides 114-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 8347128-0 1993 Highly cooperative inhibition of acetylcholinesterase by pentachlorophenol in human erythrocytes. Pentachlorophenol 57-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 8347128-1 1993 Pentachlorophenol (PCP) inhibited acetylcholinesterase (AchE) activity in human erythrocyte membranes with high cooperativity. Pentachlorophenol 0-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 8347128-1 1993 Pentachlorophenol (PCP) inhibited acetylcholinesterase (AchE) activity in human erythrocyte membranes with high cooperativity. Pentachlorophenol 0-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 8347128-1 1993 Pentachlorophenol (PCP) inhibited acetylcholinesterase (AchE) activity in human erythrocyte membranes with high cooperativity. Pentachlorophenol 19-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 8347128-1 1993 Pentachlorophenol (PCP) inhibited acetylcholinesterase (AchE) activity in human erythrocyte membranes with high cooperativity. Pentachlorophenol 19-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 8347128-3 1993 Differences in the temperature (13, 25 and 37 degrees) or treatment with 1% Triton X-100 did not clearly affect the cooperativity which, however, increased after the erythrocyte membranes were treated with 2-mercaptoethanol and iodoacetatic acid, suggesting that higher cooperativity in the inhibition of AchE by PCP may reflect conformational changes of AchE. Mercaptoethanol 206-223 acetylcholinesterase (Cartwright blood group) Homo sapiens 305-309 8347128-3 1993 Differences in the temperature (13, 25 and 37 degrees) or treatment with 1% Triton X-100 did not clearly affect the cooperativity which, however, increased after the erythrocyte membranes were treated with 2-mercaptoethanol and iodoacetatic acid, suggesting that higher cooperativity in the inhibition of AchE by PCP may reflect conformational changes of AchE. Mercaptoethanol 206-223 acetylcholinesterase (Cartwright blood group) Homo sapiens 355-359 8347128-4 1993 Thus, PCP may be useful for the study of AchE in human erythrocytes. Pentachlorophenol 6-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 8394772-7 1993 Kainate binding, like AChE, was high in CA4. Kainic Acid 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 8326133-1 1993 Vesicles released from human E by Ca(2+)-loading, ATP-depletion, or storage are enriched in several glycosylphosphatidylinositol-anchored proteins such as acetylcholinesterase (AchE) and decay-accelerating factor (DAF). Adenosine Triphosphate 50-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-175 8421706-2 1993 We previously reported that traditional acetylcholinesterase inhibitors such as BW284C51, tacrine, and physostigmine were more potent inhibitors of the acetylcholinesterase in normal axons and cell bodies than of the acetylcholinesterase in plaques and tangles. Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide 80-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 8349043-0 1993 Inositol glycan phosphate derived from human erythrocyte acetylcholinesterase glycolipid anchor and inositol cyclic 1,2-phosphate antagonize glucagon activation of glycogen phosphorylase. inositol glycan phosphate 0-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 8349043-2 1993 The inositol glycan phosphate used in this study (glycan alpha) was isolated previously from the glycoinositol phospholipid anchor of human erythrocyte acetylcholinesterase and was shown to have the structure glycine-ethanolamine-PO4-Man-Man-(N,N-dimethylethanolamine-PO4)Man- (N,N-dimethyl)GlcN-inositol-PO4. inositol glycan phosphate 4-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 8349043-2 1993 The inositol glycan phosphate used in this study (glycan alpha) was isolated previously from the glycoinositol phospholipid anchor of human erythrocyte acetylcholinesterase and was shown to have the structure glycine-ethanolamine-PO4-Man-Man-(N,N-dimethylethanolamine-PO4)Man- (N,N-dimethyl)GlcN-inositol-PO4. glycan alpha 50-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 8349043-2 1993 The inositol glycan phosphate used in this study (glycan alpha) was isolated previously from the glycoinositol phospholipid anchor of human erythrocyte acetylcholinesterase and was shown to have the structure glycine-ethanolamine-PO4-Man-Man-(N,N-dimethylethanolamine-PO4)Man- (N,N-dimethyl)GlcN-inositol-PO4. glycoinositol phospholipid 97-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 8506359-1 1993 Electrostatic calculations based on the recently solved crystal structure of acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7) indicate that this enzyme has a strong electrostatic dipole. dipole 195-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 8506359-4 1993 The affinity of quaternary ammonium compounds for aromatic rings, coupled with this electrostatic force, may work in concert to create a selective and efficient substrate-binding site in acetylcholinesterase and explain why the active site is situated at the bottom of a deep gorge lined with aromatic residues. Quaternary Ammonium Compounds 16-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-207 8100221-0 1993 Inhibition of acetylcholinesterase by distigmine bromide (Ubretid). distigmine 38-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 8100221-0 1993 Inhibition of acetylcholinesterase by distigmine bromide (Ubretid). distigmine 58-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 8100221-1 1993 A randomized phase-I study was performed in a clinical setting in 24 healthy young male subjects, aged 20 to 35 years, to investigate the influence of Ubretid on AChE inhibition following oral and i.m. distigmine 151-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-166 8100221-7 1993 The results of the AChE inhibition after Ubretid can be summarized as follows: repeated Ubretid administration as used in this trial did not lead to a cumulation of AChE inhibition. distigmine 88-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 8326086-2 1993 Most studies have evaluated effects of the OP nerve agent soman (pinacolyl methylphosphonofluoridate), an irreversible inhibitor of acetylcholinesterase. Soman 65-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-152 8506114-4 1993 This preliminary data was reinforced by the affinity purification of AChE by immobilized post-infection IgG, and the immunoprecipitation of AChE activity from ES by post-infection IgG. Einsteinium 159-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 8506114-5 1993 Finally, AChE purified by affinity chromatography on edrophonium chloride was shown to be antigenic by Western blotting, and in ELISA, against post-infection sera, although a degree of re-activity was also seen with normal human sera. Edrophonium 53-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 8449945-5 1993 However, splicing of exon 4 to exon 5, yielding a mRNA encoding the glycophospholipid-linked form of acetylcholinesterase, is seen primarily in erythroid and to a lesser extent in AtT-20 cells. glycophospholipid 68-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 8485467-1 1993 Previous studies showed that anaesthesia with the barbiturate Thiopental induces an increase in membrane fluidity and a decrease in acetylcholinesterase activity in syncytiotrophoblast plasma membranes (SPM) obtained from placentas after Cesarean section. barbituric acid 50-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-152 8485467-1 1993 Previous studies showed that anaesthesia with the barbiturate Thiopental induces an increase in membrane fluidity and a decrease in acetylcholinesterase activity in syncytiotrophoblast plasma membranes (SPM) obtained from placentas after Cesarean section. Thiopental 62-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-152 8485467-3 1993 The acetylcholinesterase activity was lower in Marcaine-anaesthetized SPM (27 +/- 3 against 39 +/- 6 in the control). Bupivacaine 47-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 8477504-2 1993 Synthesis and acetylcholinesterase inhibitory activities of omega-[N-ethyl-N-(phenylmethyl)amino]-1-phenyl-1-alkanones and their analogues with partial conformational restriction. omega-[n-ethyl-n-(phenylmethyl)amino]-1-phenyl-1-alkanones 60-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 7681755-4 1993 Intravenous administration of physostigmine, an acetylcholinesterase inhibitor, evoked a spatial frequency-dependent change in VEP amplitude. Physostigmine 30-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 8099499-1 1993 Influence of inorganic salts on the interaction of cobra venom acetylcholinesterase (EC 3.1.1.7) with hexamethonium and gallamine has been studied. inorganic salts 13-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 8099499-1 1993 Influence of inorganic salts on the interaction of cobra venom acetylcholinesterase (EC 3.1.1.7) with hexamethonium and gallamine has been studied. Hexamethonium 102-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 8099499-1 1993 Influence of inorganic salts on the interaction of cobra venom acetylcholinesterase (EC 3.1.1.7) with hexamethonium and gallamine has been studied. Gallamine Triethiodide 120-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 8099499-3 1993 The ZL psi+Z values for the complex formation between native acetylcholinesterase and hexamethonium (ZL = +2) or gallamine (ZL = +3) were in quantitative agreement with those predicted by the theory making use of psi+1 = 0.50 found earlier from the influence of salts upon the hydrolysis of acetylcholine by the enzyme. Hexamethonium 86-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 8099499-3 1993 The ZL psi+Z values for the complex formation between native acetylcholinesterase and hexamethonium (ZL = +2) or gallamine (ZL = +3) were in quantitative agreement with those predicted by the theory making use of psi+1 = 0.50 found earlier from the influence of salts upon the hydrolysis of acetylcholine by the enzyme. Gallamine Triethiodide 113-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 8099499-4 1993 Increase in the number of negative charges in acetylcholinesterase by its modification with pyromellitic dianhydride resulted in an increase of psi+1 to 0.6. pyromellitic dianhydride 92-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 8099499-5 1993 The data show that the influence of salts on the electrostatic contribution to the energy of binding of cationic substrates and inhibitors by acetylcholinesterase can be quantitatively described proceeding from the counterion condensation model of Manning by using only one empirical parameter psi+1 for a given subtype or modified form of the enzyme. Salts 36-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 8494078-1 1993 The growth hormone response to the acetylcholinesterase inhibitor pyridostigmine was measured in nine normothymic outpatients who met DSM-III-R criteria for obsessive-compulsive disorder. Pyridostigmine Bromide 66-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 8343976-1 1993 Acetylcholinesterase, an enzyme essential for the termination of the action of acetylcholine, is encoded by a single gene. Acetylcholine 79-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 8343986-7 1993 Use of acetylcholinesterase as a single pretreatment drug provided greater protection against both lethal and behavioral effects of potent organophosphates than current multicomponent drug treatments that prevent neither signs of toxicity nor behavioral deficits. Organophosphates 139-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 7-27 8343989-0 1993 Interaction of imidazolium and pyridinium dioximes with human erythrocyte acetylcholinesterase. imidazolium 15-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 8343989-0 1993 Interaction of imidazolium and pyridinium dioximes with human erythrocyte acetylcholinesterase. pyridinium dioximes 31-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 8343989-1 1993 Two pyridinium and two imidazolium dioximes were tested as reversible inhibitors of human erythrocyte acetylcholinesterase (AChE), as protectors of the enzyme against phosphorylation and as reactivators of the phosphorylated AChE. pyridine 4-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 8343989-1 1993 Two pyridinium and two imidazolium dioximes were tested as reversible inhibitors of human erythrocyte acetylcholinesterase (AChE), as protectors of the enzyme against phosphorylation and as reactivators of the phosphorylated AChE. pyridine 4-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 8343989-1 1993 Two pyridinium and two imidazolium dioximes were tested as reversible inhibitors of human erythrocyte acetylcholinesterase (AChE), as protectors of the enzyme against phosphorylation and as reactivators of the phosphorylated AChE. imidazolium dioximes 23-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 8343989-2 1993 All four dioximes reversibly inhibited AChE, protected the enzyme against phosphorylation by soman and tabun and reactivated AChE after phosphorylation by sarin, VX and tabun. dioximes 9-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 8343989-2 1993 All four dioximes reversibly inhibited AChE, protected the enzyme against phosphorylation by soman and tabun and reactivated AChE after phosphorylation by sarin, VX and tabun. dioximes 9-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 8343989-4 1993 The evaluation constants have shown that all four dioximes have about the same affinity for the catalytically active as for the phosphylated AChE. dioximes 50-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 8343998-0 1993 Reactivation of phosphorodiamidated acetylcholinesterase and neuropathy target esterase by treatment of inhibited enzyme with potassium fluoride. potassium fluoride 126-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 8343998-2 1993 We have found that both acetylcholinesterase (AChE) and neuropathy target esterase (NTE) which had been inhibited with either mipafox or with a di-n-butylphosphorodiamidate could be reactivated by prolonged treatment with aqueous potassium fluoride (KF): the reaction proceeded with first-order kinetics. mipafox 126-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 8343998-2 1993 We have found that both acetylcholinesterase (AChE) and neuropathy target esterase (NTE) which had been inhibited with either mipafox or with a di-n-butylphosphorodiamidate could be reactivated by prolonged treatment with aqueous potassium fluoride (KF): the reaction proceeded with first-order kinetics. mipafox 126-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 8343998-2 1993 We have found that both acetylcholinesterase (AChE) and neuropathy target esterase (NTE) which had been inhibited with either mipafox or with a di-n-butylphosphorodiamidate could be reactivated by prolonged treatment with aqueous potassium fluoride (KF): the reaction proceeded with first-order kinetics. di-n-butylphosphorodiamidate 144-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 8343998-2 1993 We have found that both acetylcholinesterase (AChE) and neuropathy target esterase (NTE) which had been inhibited with either mipafox or with a di-n-butylphosphorodiamidate could be reactivated by prolonged treatment with aqueous potassium fluoride (KF): the reaction proceeded with first-order kinetics. di-n-butylphosphorodiamidate 144-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 8343998-2 1993 We have found that both acetylcholinesterase (AChE) and neuropathy target esterase (NTE) which had been inhibited with either mipafox or with a di-n-butylphosphorodiamidate could be reactivated by prolonged treatment with aqueous potassium fluoride (KF): the reaction proceeded with first-order kinetics. potassium fluoride 230-248 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 8343998-2 1993 We have found that both acetylcholinesterase (AChE) and neuropathy target esterase (NTE) which had been inhibited with either mipafox or with a di-n-butylphosphorodiamidate could be reactivated by prolonged treatment with aqueous potassium fluoride (KF): the reaction proceeded with first-order kinetics. potassium fluoride 230-248 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 8343998-2 1993 We have found that both acetylcholinesterase (AChE) and neuropathy target esterase (NTE) which had been inhibited with either mipafox or with a di-n-butylphosphorodiamidate could be reactivated by prolonged treatment with aqueous potassium fluoride (KF): the reaction proceeded with first-order kinetics. lysylphenylalanine 250-252 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 8343998-2 1993 We have found that both acetylcholinesterase (AChE) and neuropathy target esterase (NTE) which had been inhibited with either mipafox or with a di-n-butylphosphorodiamidate could be reactivated by prolonged treatment with aqueous potassium fluoride (KF): the reaction proceeded with first-order kinetics. lysylphenylalanine 250-252 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 8343998-5 1993 We conclude that it is likely that the mipafox-enzyme bond in inhibited NTE and AChE is relatively strong but that aging has not occurred. mipafox 39-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 8344000-1 1993 O-Ethyl-O-4-nitrophenylphosphoramidate is a short-acting anticholinesterase and a possible candidate for a prophylactic agent against nerve agents since human acetylcholinesterase inhibited by this agent undergoes rapid spontaneous reactivation which can be accelerated further, if necessary, by treatment with oximes. O-ethyl O-4-nitrophenyl phosphoramidate 0-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 8344000-1 1993 O-Ethyl-O-4-nitrophenylphosphoramidate is a short-acting anticholinesterase and a possible candidate for a prophylactic agent against nerve agents since human acetylcholinesterase inhibited by this agent undergoes rapid spontaneous reactivation which can be accelerated further, if necessary, by treatment with oximes. Oximes 311-317 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 8344646-3 1993 Further studies have shown that pyridostigmine (Pyr), an acetylcholinesterase inhibitor, is capable of augmenting GH in obesity by means of somatostatin inhibition. Pyridostigmine Bromide 32-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 8344646-3 1993 Further studies have shown that pyridostigmine (Pyr), an acetylcholinesterase inhibitor, is capable of augmenting GH in obesity by means of somatostatin inhibition. Pyridostigmine Bromide 48-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 8503347-5 1993 Organophosphate pesticides act as irreversible acetylcholinesterase inhibitors, while carbamate pesticides produce reversible effects. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 8492300-0 1993 Interactions in vitro of some organophosphoramidates with neuropathy target esterase and acetylcholinesterase of hen brain. organophosphoramidates 30-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 8492300-11 1993 Several N-alkyl phosphoromonoamidates were found to be potent and selective inhibitors of NTE: second-order rate constant for O-n-pentyl N-benzylphosphoramido-fluoridate (Cmpd 6) = 5.6 x 10(7) M-1 min-1 at 37 degrees, which is about 100x higher than for acetylcholinesterase (AChE). n-alkyl phosphoromonoamidates 8-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 254-274 8492300-11 1993 Several N-alkyl phosphoromonoamidates were found to be potent and selective inhibitors of NTE: second-order rate constant for O-n-pentyl N-benzylphosphoramido-fluoridate (Cmpd 6) = 5.6 x 10(7) M-1 min-1 at 37 degrees, which is about 100x higher than for acetylcholinesterase (AChE). n-alkyl phosphoromonoamidates 8-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 276-280 8492300-11 1993 Several N-alkyl phosphoromonoamidates were found to be potent and selective inhibitors of NTE: second-order rate constant for O-n-pentyl N-benzylphosphoramido-fluoridate (Cmpd 6) = 5.6 x 10(7) M-1 min-1 at 37 degrees, which is about 100x higher than for acetylcholinesterase (AChE). o-n-pentyl n-benzylphosphoramido-fluoridate 126-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 254-274 8492300-11 1993 Several N-alkyl phosphoromonoamidates were found to be potent and selective inhibitors of NTE: second-order rate constant for O-n-pentyl N-benzylphosphoramido-fluoridate (Cmpd 6) = 5.6 x 10(7) M-1 min-1 at 37 degrees, which is about 100x higher than for acetylcholinesterase (AChE). o-n-pentyl n-benzylphosphoramido-fluoridate 126-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 276-280 8492300-12 1993 Inhibited NTE and AChE from several chiral phosphoromono-amidates did not reactivate spontaneously (21 hours at 37 degrees). phosphoromono-amidates 43-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 8492300-13 1993 Virtually 100% reactivation by KF of AChE inhibited by phosphoromonoamidates was achieved at all times tested. phosphoromonoamidates 55-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 8492300-14 1993 Acetylcholinesterase inhibited by 2,5-dichlorophenyl N,N"-di-n-butylphosphorodiamidate was 42-56% reactivated by incubation with KF (192 mM in pH 5.2 buffer for 30 minutes at 37 degrees). 2,5-dichlorophenyl n,n"-di-n-butylphosphorodiamidate 34-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 8501917-3 1993 The transmitter acetylcholine (ACh) is released at the presynaptic membrane, diffuses through the cleft where acetylcholinesterase is homogeneously distributed and then reaches the postsynaptic surface where the receptor is located. Acetylcholine 16-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 8501917-3 1993 The transmitter acetylcholine (ACh) is released at the presynaptic membrane, diffuses through the cleft where acetylcholinesterase is homogeneously distributed and then reaches the postsynaptic surface where the receptor is located. Acetylcholine 31-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 8458061-4 1993 To facilitate expression in the prokaryotic system, recombinant human AChE (rhAChE) cDNA was modified at the N terminus by oligonucleotide substitutions in order to replace some of the GC-rich regions by AT. Oligonucleotides 123-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 8421706-2 1993 We previously reported that traditional acetylcholinesterase inhibitors such as BW284C51, tacrine, and physostigmine were more potent inhibitors of the acetylcholinesterase in normal axons and cell bodies than of the acetylcholinesterase in plaques and tangles. Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide 80-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 8421706-2 1993 We previously reported that traditional acetylcholinesterase inhibitors such as BW284C51, tacrine, and physostigmine were more potent inhibitors of the acetylcholinesterase in normal axons and cell bodies than of the acetylcholinesterase in plaques and tangles. Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide 80-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 8421706-2 1993 We previously reported that traditional acetylcholinesterase inhibitors such as BW284C51, tacrine, and physostigmine were more potent inhibitors of the acetylcholinesterase in normal axons and cell bodies than of the acetylcholinesterase in plaques and tangles. Tacrine 90-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 8421706-2 1993 We previously reported that traditional acetylcholinesterase inhibitors such as BW284C51, tacrine, and physostigmine were more potent inhibitors of the acetylcholinesterase in normal axons and cell bodies than of the acetylcholinesterase in plaques and tangles. Tacrine 90-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 8421706-2 1993 We previously reported that traditional acetylcholinesterase inhibitors such as BW284C51, tacrine, and physostigmine were more potent inhibitors of the acetylcholinesterase in normal axons and cell bodies than of the acetylcholinesterase in plaques and tangles. Tacrine 90-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 8421706-2 1993 We previously reported that traditional acetylcholinesterase inhibitors such as BW284C51, tacrine, and physostigmine were more potent inhibitors of the acetylcholinesterase in normal axons and cell bodies than of the acetylcholinesterase in plaques and tangles. Physostigmine 103-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 8421706-2 1993 We previously reported that traditional acetylcholinesterase inhibitors such as BW284C51, tacrine, and physostigmine were more potent inhibitors of the acetylcholinesterase in normal axons and cell bodies than of the acetylcholinesterase in plaques and tangles. Physostigmine 103-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 8421706-2 1993 We previously reported that traditional acetylcholinesterase inhibitors such as BW284C51, tacrine, and physostigmine were more potent inhibitors of the acetylcholinesterase in normal axons and cell bodies than of the acetylcholinesterase in plaques and tangles. Physostigmine 103-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 8128832-2 1993 The rationale for the use of AChE inhibitors is based on their abilities to prevent breakdown of acetylcholine released from surviving nerve terminals. Acetylcholine 97-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 27314788-0 1993 Ethanolysis of Substituted 2-Ethoxy-1,3,2-oxazaphospholidine and -thiazaphospholidine Oxides Monitored by (31)P-NMR as a Model for Interaction with Acetylcholinesterase. 2-ethoxy-1,3,2-oxazaphospholidine 27-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-168 27314788-0 1993 Ethanolysis of Substituted 2-Ethoxy-1,3,2-oxazaphospholidine and -thiazaphospholidine Oxides Monitored by (31)P-NMR as a Model for Interaction with Acetylcholinesterase. -thiazaphospholidine oxides 65-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-168 8406941-2 1993 The assays of acetylcholinesterase (AChE) activity in whole blood and erythrocytes are mainly applied to estimate inhibition by organophosphates (OPs) and carbamates. Organophosphates 128-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 8406941-2 1993 The assays of acetylcholinesterase (AChE) activity in whole blood and erythrocytes are mainly applied to estimate inhibition by organophosphates (OPs) and carbamates. Organophosphates 128-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 8406941-2 1993 The assays of acetylcholinesterase (AChE) activity in whole blood and erythrocytes are mainly applied to estimate inhibition by organophosphates (OPs) and carbamates. Organophosphates 146-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 8406941-2 1993 The assays of acetylcholinesterase (AChE) activity in whole blood and erythrocytes are mainly applied to estimate inhibition by organophosphates (OPs) and carbamates. Organophosphates 146-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 8406941-2 1993 The assays of acetylcholinesterase (AChE) activity in whole blood and erythrocytes are mainly applied to estimate inhibition by organophosphates (OPs) and carbamates. Carbamates 155-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 8406941-2 1993 The assays of acetylcholinesterase (AChE) activity in whole blood and erythrocytes are mainly applied to estimate inhibition by organophosphates (OPs) and carbamates. Carbamates 155-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 8272199-2 1993 In this study we have evaluated the effects of acetylcholinesterase inhibition by pyridostigmine on growth hormone (GH), adrenocorticotropic hormone (ACTH) and cortisol secretion and on their responses to GH-releasing hormone (GHRH) and corticotropin-releasing hormone (CRH) in 7 patients with primary degenerative dementia and in 8 sex- and age-matched controls. Pyridostigmine Bromide 82-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 8248532-0 1993 What have we learned from the THA trials to facilitate testing of new AChE inhibitors. Tacrine 30-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 8248533-4 1993 The results presented with SDZ ENA 713 indicate that the disadvantages of AChE inhibitors might be overcome by improving CNS selectivity and thereby decreasing the peripheral cholinergic effects and toxicity. Rivastigmine 27-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 8493783-3 1993 Also, there have been no significant differences in efficacy and speed of reactivation of acetylcholinesterase inhibited by organophosphates when HI-6 is applied in the form of permanent intravenous infusion or repeated intramuscular injections. Organophosphates 124-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 7678519-2 1993 It has been previously demonstrated that glycan phosphatidylinositol-linked (GPI-linked) proteins such as decay accelerating factor and acetylcholinesterase are concentrated in these vesicles relative to the erythrocyte membrane. Glycosylphosphatidylinositols 41-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 1293953-1 1992 The aim of this work was to evaluate a possible correlation between erythrocyte acetylcholinesterase activity (AChE) and membrane fluidity expressed by fluorescence polarization of--1,6--diphenyl 1,3,5--hexatriene (DPH). Diphenylhexatriene 180-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 1293953-1 1992 The aim of this work was to evaluate a possible correlation between erythrocyte acetylcholinesterase activity (AChE) and membrane fluidity expressed by fluorescence polarization of--1,6--diphenyl 1,3,5--hexatriene (DPH). Phenytoin 215-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 1293431-2 1992 Because AChE shows substrate specificity and hydrolyzes acetylthiocholine but not butrylthiocholine, this parasitic enzyme is likely a true acetylcholinesterase. Acetylthiocholine 56-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-12 1293431-3 1992 The latter also resembles an AChE enzyme in the human filarial parasite B. malayi which hydrolyzes acetylthiocholine iodide three times faster than butrylthiocholine iodide. acetylthiocholine iodide 99-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 1293431-3 1992 The latter also resembles an AChE enzyme in the human filarial parasite B. malayi which hydrolyzes acetylthiocholine iodide three times faster than butrylthiocholine iodide. butrylthiocholine iodide 148-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 15463554-3 1992 Acetylcholine activity is terminated by hydrolysis by acetylcholinesterase (AChE). Acetylcholine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 15463554-3 1992 Acetylcholine activity is terminated by hydrolysis by acetylcholinesterase (AChE). Acetylcholine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 1282748-2 1992 Neuronal AChE can be secreted from several brain regions, while purified AChE possesses several properties (in addition to its cholinesterase activity) that can affect neuronal function, including the abilities to influence certain membrane conductances, enhance excitatory amino acid transmission and hydrolyse peptides. Excitatory Amino Acids 263-284 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 8493783-3 1993 Also, there have been no significant differences in efficacy and speed of reactivation of acetylcholinesterase inhibited by organophosphates when HI-6 is applied in the form of permanent intravenous infusion or repeated intramuscular injections. asoxime chloride 146-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 1380483-1 1992 To establish the chromosomal location of the human ACHE gene encoding the acetylcholine hydrolyzing enzyme acetylcholinesterase (ACHE, acetylcholine acetylhydrolase, E.C. Acetylcholine 74-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 1329966-4 1992 This observation suggests that, as previously reported for human erythrocyte AChE, an acylation of the inositol ring in the glycolipid anchor of rabbit erythrocyte AChE (that does not occur in lymphocytes) prevents the cleavage. Inositol 103-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 1329966-4 1992 This observation suggests that, as previously reported for human erythrocyte AChE, an acylation of the inositol ring in the glycolipid anchor of rabbit erythrocyte AChE (that does not occur in lymphocytes) prevents the cleavage. Glycolipids 124-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 1417975-0 1992 Phenothiazines inhibit acetylcholinesterase by concentration-dependent-type kinetics. Phenothiazines 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 1417975-6 1992 Results support the notion that phenothiazines may interact with AChE both as monomers and micellar aggregates, producing different inhibitory effects. Phenothiazines 32-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 1404460-6 1992 Results suggest an associated increase of serum acetylcholinesterase with triglyceride levels in diabetics and may point to a possible association between increased serum acetylcholinesterase and vascular complications in Jamaican diabetics. Triglycerides 74-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 1404460-6 1992 Results suggest an associated increase of serum acetylcholinesterase with triglyceride levels in diabetics and may point to a possible association between increased serum acetylcholinesterase and vascular complications in Jamaican diabetics. Triglycerides 74-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-191 1461569-1 1992 Differences in glycosylation of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in human brain, plasma and cerebrospinal fluid (CSF) have been investigated by means of their interaction with agarose-immobilized lectins. Sepharose 205-212 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 1393597-4 1992 The effect of three clinically significant acetylcholinesterase inhibitors, heptyl-physostigmine, physostigmine and edrophonium, on aqueous-soluble acetylcholinesterase molecular forms of the caudate-putamen was investigated. physostigmine heptyl 76-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-168 1380451-0 1992 Molecular architecture of acetylcholinesterase collagen-tailed forms; construction of a glycolipid-tailed tetramer. Glycolipids 88-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 1380451-6 1992 This was confirmed by creating a chimeric subunit (QN/HC), in which QN was linked to the C-terminal peptide of the H subunit of Torpedo AChE, which contains the glycophosphatidylinositol (GPI) cleavage/attachment signal: co-expression of AChET and QN/NC produced GPI-anchored tetramers, which were sensitive to PI-PLC and largely exposed to the external surface of the cells. glycophosphatidylinositol 161-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 1380451-6 1992 This was confirmed by creating a chimeric subunit (QN/HC), in which QN was linked to the C-terminal peptide of the H subunit of Torpedo AChE, which contains the glycophosphatidylinositol (GPI) cleavage/attachment signal: co-expression of AChET and QN/NC produced GPI-anchored tetramers, which were sensitive to PI-PLC and largely exposed to the external surface of the cells. GPI 1046 188-191 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 1447418-3 1992 The comparative study of the inhibitory action of water-soluble derivatives of hindered phenols and fatty-soluble ionol made it possible to reveal possible contributions to the inhibition of both direct and mediated (by the membrane microsurroundings) effects on the membrane-bound AChE by the studied synthetic bioantioxidants. Water 50-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 282-286 1412499-4 1992 We have found that the inhibition of both eel acetylcholinesterase (eel AChE, EC 3.1.1.7) and human serum cholinesterase (human BuChE, EC 3.1.1.8) by carbaryl was enhanced by several oximes. Carbaryl 150-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 1412499-4 1992 We have found that the inhibition of both eel acetylcholinesterase (eel AChE, EC 3.1.1.7) and human serum cholinesterase (human BuChE, EC 3.1.1.8) by carbaryl was enhanced by several oximes. Oximes 183-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 1412499-5 1992 Based on 95% confidence limits the rank order of potentiation with eel AChE was TMB-4 = Toxogonin > HS-6 = HI-6 > 2-PAM Cl. Trimedoxime 80-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 1412499-5 1992 Based on 95% confidence limits the rank order of potentiation with eel AChE was TMB-4 = Toxogonin > HS-6 = HI-6 > 2-PAM Cl. HS 6 103-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 1412499-5 1992 Based on 95% confidence limits the rank order of potentiation with eel AChE was TMB-4 = Toxogonin > HS-6 = HI-6 > 2-PAM Cl. asoxime chloride 110-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 1412499-5 1992 Based on 95% confidence limits the rank order of potentiation with eel AChE was TMB-4 = Toxogonin > HS-6 = HI-6 > 2-PAM Cl. pralidoxime 120-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 1325836-9 1992 Using [125I]TID-labelled mf-AChE as substrate, radiolabelled diradylglycerol was obtained with both peak activities. diarachidonyl diglyceride 61-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 1445434-4 1992 It is demonstrated that S-alkynyl esters of thioacetic acid are slowly hydrolyzed by acetylcholinesterase and cholinesterase without irreversible inhibition of the enzymes. s-alkynyl esters 24-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 1445434-4 1992 It is demonstrated that S-alkynyl esters of thioacetic acid are slowly hydrolyzed by acetylcholinesterase and cholinesterase without irreversible inhibition of the enzymes. thioacetic acid 44-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 1446827-6 1992 The purified (specific activity of 6000 units per mg protein) homodimer and tetramer enzyme molecules displayed typical AChE biochemical properties: a Km value of 120 microM for acetylthiocholine; a kcat value of 3.9 x 10(5)/min, and selective by AChE-specific inhibitors. Acetylthiocholine 178-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 1465181-0 1992 Acetylcholinesterase and its association with heparan sulphate proteoglycans in cortical amyloid deposits of Alzheimer"s disease. Heparitin Sulfate 46-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 1465181-2 1992 In this study, we used this technique to show that acetylcholinesterase localized in either frozen or fixed neocortical tissue sections is removed after treatment with various glycosaminoglycans, heparinases or proteases. Glycosaminoglycans 176-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 1465181-7 1992 Our results suggest that acetylcholinesterase is anchored to and may be released from the heparan sulphate glycosaminoglycans shown to be contained in the lesions. heparan sulphate glycosaminoglycans 90-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 1396557-7 1992 We propose that binding of acetylcholine, on the surface of AChE, may trigger sequence of conformational changes extending from the peripheral anionic site through W286 to D74, at the entrance of the "gorge", and down to the catalytic center (through Y341 to F338 and Y337). Acetylcholine 27-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 21776148-0 1992 Serum acetylcholinesterase level in the patients of opioid (brown sugar) dependence. Sugars 66-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-26 21776148-1 1992 The authors compared the serum acetylcholinesterase level in the patients of brown sugar dependence and the normal volunteers. Sugars 83-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 21776148-2 1992 Significantly lower level of serum acetylcholinesterase was found in patients of brown sugar dependence. Sugars 87-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 1357095-7 1992 DHBT is also shown to be a noncompetitive inhibitor of AChE in vitro. 5,5'-dihydroxy-4,4'-bitryptamine 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 1298399-2 1992 A home-made packed bed microbioreactor system containing immobilized enzyme acetylcholinesterase (ACHE) in human red blood cell membrane and choline oxidase (CHO) from alcaligenes was used for the post-column conversion of acetylcholine to hydrogen peroxide which was detected by an electrochemical detector. Acetylcholine 76-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 1298399-2 1992 A home-made packed bed microbioreactor system containing immobilized enzyme acetylcholinesterase (ACHE) in human red blood cell membrane and choline oxidase (CHO) from alcaligenes was used for the post-column conversion of acetylcholine to hydrogen peroxide which was detected by an electrochemical detector. Hydrogen Peroxide 240-257 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 1298399-2 1992 A home-made packed bed microbioreactor system containing immobilized enzyme acetylcholinesterase (ACHE) in human red blood cell membrane and choline oxidase (CHO) from alcaligenes was used for the post-column conversion of acetylcholine to hydrogen peroxide which was detected by an electrochemical detector. Hydrogen Peroxide 240-257 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 1494302-0 1992 Inhibition of human brain and RBC acetylcholinesterase (AChE) by heptylphysostigmine (HPTL). physostigmine heptyl 65-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 1494302-0 1992 Inhibition of human brain and RBC acetylcholinesterase (AChE) by heptylphysostigmine (HPTL). physostigmine heptyl 86-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 1494302-1 1992 Heptylphysostigmine (HPTL), a derivative of the AChE inhibitor physostigmine (PHY), is under investigation as a therapeutic agent in Alzheimer"s disease. physostigmine heptyl 0-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 1494302-1 1992 Heptylphysostigmine (HPTL), a derivative of the AChE inhibitor physostigmine (PHY), is under investigation as a therapeutic agent in Alzheimer"s disease. physostigmine heptyl 21-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 1494302-1 1992 Heptylphysostigmine (HPTL), a derivative of the AChE inhibitor physostigmine (PHY), is under investigation as a therapeutic agent in Alzheimer"s disease. Physostigmine 6-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 1517212-2 1992 Evidence for the involvement of Ser-203, His-447, and Glu-334 in the catalytic triad of human acetylcholinesterase was provided by substitution of these amino acids by alanine residues. Serine 32-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 1517212-2 1992 Evidence for the involvement of Ser-203, His-447, and Glu-334 in the catalytic triad of human acetylcholinesterase was provided by substitution of these amino acids by alanine residues. Histidine 41-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 1517212-2 1992 Evidence for the involvement of Ser-203, His-447, and Glu-334 in the catalytic triad of human acetylcholinesterase was provided by substitution of these amino acids by alanine residues. Glutamic Acid 54-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 1517212-2 1992 Evidence for the involvement of Ser-203, His-447, and Glu-334 in the catalytic triad of human acetylcholinesterase was provided by substitution of these amino acids by alanine residues. Alanine 168-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 1517212-7 1992 Another type of substitution, that of Asp-74 by Gly or Asn, generated an active enzyme with increased resistance to succinylcholine and dibucaine; thus mimicking in an AChE molecule the phenotype of the atypical butyrylcholinesterase natural variant (D70G mutation). Succinylcholine 116-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-172 1517212-7 1992 Another type of substitution, that of Asp-74 by Gly or Asn, generated an active enzyme with increased resistance to succinylcholine and dibucaine; thus mimicking in an AChE molecule the phenotype of the atypical butyrylcholinesterase natural variant (D70G mutation). Dibucaine 136-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-172 1447418-1 1992 The inhibitory effects of synthetic antioxidants (3-oxypyridine, pyrimidine and hindered phenols) on the enzymic activity of membrane-bound acetylcholinesterase (AChE) was studied. 3-oxypyridine 50-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-160 1447418-1 1992 The inhibitory effects of synthetic antioxidants (3-oxypyridine, pyrimidine and hindered phenols) on the enzymic activity of membrane-bound acetylcholinesterase (AChE) was studied. 3-oxypyridine 50-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-166 1447418-1 1992 The inhibitory effects of synthetic antioxidants (3-oxypyridine, pyrimidine and hindered phenols) on the enzymic activity of membrane-bound acetylcholinesterase (AChE) was studied. pyrimidine 65-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-160 1447418-1 1992 The inhibitory effects of synthetic antioxidants (3-oxypyridine, pyrimidine and hindered phenols) on the enzymic activity of membrane-bound acetylcholinesterase (AChE) was studied. pyrimidine 65-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-166 1447418-1 1992 The inhibitory effects of synthetic antioxidants (3-oxypyridine, pyrimidine and hindered phenols) on the enzymic activity of membrane-bound acetylcholinesterase (AChE) was studied. Phenols 89-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-160 1447418-1 1992 The inhibitory effects of synthetic antioxidants (3-oxypyridine, pyrimidine and hindered phenols) on the enzymic activity of membrane-bound acetylcholinesterase (AChE) was studied. Phenols 89-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-166 1447418-2 1992 In terms of estimated kinetic characteristics of AChE-reaction (KM, Vmax, KI), the pattern of enzyme inhibition by the hindered phenol compounds was found to be of non-competitive or mixed type depending on the inhibitor structure or on the substrate acetylcholine or acetylthiocholine used. Phenol 128-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 1447418-2 1992 In terms of estimated kinetic characteristics of AChE-reaction (KM, Vmax, KI), the pattern of enzyme inhibition by the hindered phenol compounds was found to be of non-competitive or mixed type depending on the inhibitor structure or on the substrate acetylcholine or acetylthiocholine used. Acetylcholine 251-264 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 1447418-2 1992 In terms of estimated kinetic characteristics of AChE-reaction (KM, Vmax, KI), the pattern of enzyme inhibition by the hindered phenol compounds was found to be of non-competitive or mixed type depending on the inhibitor structure or on the substrate acetylcholine or acetylthiocholine used. Acetylthiocholine 268-285 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 1447418-3 1992 The comparative study of the inhibitory action of water-soluble derivatives of hindered phenols and fatty-soluble ionol made it possible to reveal possible contributions to the inhibition of both direct and mediated (by the membrane microsurroundings) effects on the membrane-bound AChE by the studied synthetic bioantioxidants. Phenols 88-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 282-286 1380483-1 1992 To establish the chromosomal location of the human ACHE gene encoding the acetylcholine hydrolyzing enzyme acetylcholinesterase (ACHE, acetylcholine acetylhydrolase, E.C. Acetylcholine 74-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 1380483-1 1992 To establish the chromosomal location of the human ACHE gene encoding the acetylcholine hydrolyzing enzyme acetylcholinesterase (ACHE, acetylcholine acetylhydrolase, E.C. Acetylcholine 74-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 1459649-2 1992 Remarkable inhibition of enzymes acetylcholinesterase and choline acetylase and significant accumulation of neurotransmitter acetylcholine were observed in permethrin treated animals. Permethrin 156-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 1322133-3 1992 )/Km in the hydrolysis of various substrates by acetylcholinesterase (AcChE) is due to normal 2H2O effects (1.8-2.8) for the parameter k(cat.) 2h2o 94-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 1322133-3 1992 )/Km in the hydrolysis of various substrates by acetylcholinesterase (AcChE) is due to normal 2H2O effects (1.8-2.8) for the parameter k(cat.) 2h2o 94-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-75 1511329-2 1992 The subset of neurons particularly sensitive to AChE are characterized by functionally active apical dendrites extending into the pars reticulata and generating a powerful calcium conductance. Calcium 172-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 1610046-2 1992 Nerve agents are highly potent and rapidly acting organophosphorus compounds that irreversibly bind and inactive acetylcholinesterase. organophosphorus 50-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-133 1407268-0 1992 Differential effects of ethanol on membrane-bound and soluble acetylcholinesterase from sarcoplasmic reticulum membranes. Ethanol 24-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 1407268-1 1992 The action of ethanol on the activity of membrane-bound and soluble acetylcholinesterase (AChE) in sarcoplasmic reticulum of skeletal muscle has been studied. Ethanol 14-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 1407268-1 1992 The action of ethanol on the activity of membrane-bound and soluble acetylcholinesterase (AChE) in sarcoplasmic reticulum of skeletal muscle has been studied. Ethanol 14-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 1407268-2 1992 Treatment of membranes with 2.5-12.5% v/v ethanol produced a slight stimulation of the AChE activity and inhibition at higher concentration. Ethanol 42-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 1407268-5 1992 Isolated 16 S (A12), 10.5 S (G4) and 4.5 S (G1) forms of AChE were inhibited by ethanol to a similar extent. Ethanol 80-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 1407689-4 1992 NADPH-d reactive patches corresponded to and showed a similar shift in the intensity of staining during development as acetylcholinesterase (AChE) reactive striosomes. NADP 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 1358448-11 1992 Acetylcholinesterase activity was significantly stimulated by retinoic acid and by gamma-interferon. Tretinoin 62-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 1506033-9 1992 Nifedipine, naloxone and DMSO produced a decrease in AchE activity in S1 and S2 segments. Nifedipine 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 1506033-9 1992 Nifedipine, naloxone and DMSO produced a decrease in AchE activity in S1 and S2 segments. Naloxone 12-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 1506033-9 1992 Nifedipine, naloxone and DMSO produced a decrease in AchE activity in S1 and S2 segments. Dimethyl Sulfoxide 25-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 1519032-0 1992 In vitro and in vivo effect of diethylcarbamazine on the activity of acetylcholinesterase from Wuchereria bancrofti infected human serum. Diethylcarbamazine 31-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 1519032-4 1992 Further, the effect of the antifilarial drug diethylcarbamazine (DEC), on the AChE activity of infected and normal serum was studied in in vivo and in vitro experiments. Diethylcarbamazine 45-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 1519032-4 1992 Further, the effect of the antifilarial drug diethylcarbamazine (DEC), on the AChE activity of infected and normal serum was studied in in vivo and in vitro experiments. Diethylcarbamazine 65-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 1519032-5 1992 In vitro, DEC was found to be effective only with respect to AChE from asymptomatic microfilaremic serum where 75% decrease in enzyme activity was observed at 100 mumol. Diethylcarbamazine 10-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 1519032-9 1992 In vitro and in vivo the same concentration of DEC has negligible effect on the normal serum suggesting that in case of asymptomatic microfilaremic serum the increased activity of AChE is different in nature than the host acetylcho-[abstract incomplete in journal] Diethylcarbamazine 47-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 1388703-2 1992 Acetylcholinesterase (AChE), an enzyme responsible for the break-down of acetylcholine, is found both in cholinergic and non-cholinergic neurons in the central nervous system. Acetylcholine 73-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 1359747-11 1992 The thiourea compounds were found to inhibit acetylcholinesterase activity by competing with its substrate. Thiourea 4-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 1599955-1 1992 To obtain information about the mode of attachment of amphiphilic monomers of acetylcholinesterase (AChE) in sarcoplasmic reticulum (SR) of skeletal muscle, attempts were made to release the enzyme by alkaline hydroxylamine. alkaline hydroxylamine 201-223 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 1599955-1 1992 To obtain information about the mode of attachment of amphiphilic monomers of acetylcholinesterase (AChE) in sarcoplasmic reticulum (SR) of skeletal muscle, attempts were made to release the enzyme by alkaline hydroxylamine. alkaline hydroxylamine 201-223 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 1599955-4 1992 Molecular forms of 16S (A12), 10.5S (G4) and 4.0S (G1) are separated by sedimentation analyses of Triton X-100 or bicarbonate-solubilized AChE. Bicarbonates 114-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 1497415-1 1992 Acetylcholinesterase (AChe) hydrolyses acetylcholine to choline and acetate, thereby inactivating the neurotransmitter. Acetylcholine 39-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 1497415-1 1992 Acetylcholinesterase (AChe) hydrolyses acetylcholine to choline and acetate, thereby inactivating the neurotransmitter. Acetylcholine 39-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 1497415-1 1992 Acetylcholinesterase (AChe) hydrolyses acetylcholine to choline and acetate, thereby inactivating the neurotransmitter. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 1497415-1 1992 Acetylcholinesterase (AChe) hydrolyses acetylcholine to choline and acetate, thereby inactivating the neurotransmitter. Acetates 68-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 1497415-1 1992 Acetylcholinesterase (AChe) hydrolyses acetylcholine to choline and acetate, thereby inactivating the neurotransmitter. Acetates 68-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 1504265-0 1992 Inhibition of acetylcholinesterase by hemicholiniums, conformationally constrained choline analogues. Hemicholinium 3 38-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 1504265-3 1992 2-Substituted-2-hydroxy-4,4-dimethylmorpholiniums (hemicholiniums) inhibit acetylcholinesterase (EC 3.1.1.7)-catalyzed hydrolysis of acetylthiocholine (ATCh). 2-substituted-2-hydroxy-4,4-dimethylmorpholiniums 0-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 1504265-3 1992 2-Substituted-2-hydroxy-4,4-dimethylmorpholiniums (hemicholiniums) inhibit acetylcholinesterase (EC 3.1.1.7)-catalyzed hydrolysis of acetylthiocholine (ATCh). Hemicholinium 3 51-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 1504265-3 1992 2-Substituted-2-hydroxy-4,4-dimethylmorpholiniums (hemicholiniums) inhibit acetylcholinesterase (EC 3.1.1.7)-catalyzed hydrolysis of acetylthiocholine (ATCh). Acetylthiocholine 133-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 1504265-3 1992 2-Substituted-2-hydroxy-4,4-dimethylmorpholiniums (hemicholiniums) inhibit acetylcholinesterase (EC 3.1.1.7)-catalyzed hydrolysis of acetylthiocholine (ATCh). Acetylthiocholine 152-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 1504265-7 1992 The conformation of AChE-bound choline must be gauche to support our suggestion that hemicholiniums are conformationally constrained analogues of choline. Choline 31-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 1504265-7 1992 The conformation of AChE-bound choline must be gauche to support our suggestion that hemicholiniums are conformationally constrained analogues of choline. Hemicholinium 3 85-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 1504265-7 1992 The conformation of AChE-bound choline must be gauche to support our suggestion that hemicholiniums are conformationally constrained analogues of choline. Choline 146-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 1504265-10 1992 The binding by AChE of the hemicholiniums of various sizes and the strong binding of 5 support an earlier proposal [Schowen, K. B., Smissman, E. E., and Stephen, W. F., Jr. (1975) J. Med. Hemicholinium 3 27-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 1504265-12 1992 18, 292-300] that the active site of AChE has ample space for rotation about the C-C bond in choline. Choline 93-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 1374519-1 1992 The ACHE and BCHE genes, encoding the acetylcholine hydrolysing enzymes acetylcholinesterase (ACHE) and butyrylcholinesterase (BCHE), co-amplify with several oncogenes in leukemic patients with platelet deficiency (thrombocytopenia). Acetylcholine 38-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 1374519-1 1992 The ACHE and BCHE genes, encoding the acetylcholine hydrolysing enzymes acetylcholinesterase (ACHE) and butyrylcholinesterase (BCHE), co-amplify with several oncogenes in leukemic patients with platelet deficiency (thrombocytopenia). Acetylcholine 38-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 1588924-0 1992 Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities. Ambenonium Chloride 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 1548461-1 1992 Acetylcholinesterases (EC 3.1.1.7, AChE) have varying amounts of carbohydrates attached to the core protein. Carbohydrates 65-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 1548461-3 1992 From the differences in molecular mass determined on sodium dodecyl sulfate-polyacrylamide gel before and after deglycosylation with N-glycosidase F (EC 3.2.2.18), it is seen that dimeric AChE from red cell membranes is more heavily glycosylated than the tetrameric brain enzyme. Sodium Dodecyl Sulfate 53-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-192 1548461-3 1992 From the differences in molecular mass determined on sodium dodecyl sulfate-polyacrylamide gel before and after deglycosylation with N-glycosidase F (EC 3.2.2.18), it is seen that dimeric AChE from red cell membranes is more heavily glycosylated than the tetrameric brain enzyme. polyacrylamide 76-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-192 1552502-1 1992 The histaminergic H2 antagonist, ranitidine, has also been found to significantly inhibit acetylcholinesterase (AChE) in vitro. Ranitidine 33-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 1552502-1 1992 The histaminergic H2 antagonist, ranitidine, has also been found to significantly inhibit acetylcholinesterase (AChE) in vitro. Ranitidine 33-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 1552502-4 1992 The most active AChE inhibitors were N,N"-disubstituted derivatives of 2-nitro-1,1-ethenediamine and 4,6-dinitro-1,3-benzenediamine, with compound 8 demonstrating activity greater than physostigmine. n,n"-disubstituted 37-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 1552502-4 1992 The most active AChE inhibitors were N,N"-disubstituted derivatives of 2-nitro-1,1-ethenediamine and 4,6-dinitro-1,3-benzenediamine, with compound 8 demonstrating activity greater than physostigmine. 2-nitro-1,1-ethenediamine 71-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 1552502-4 1992 The most active AChE inhibitors were N,N"-disubstituted derivatives of 2-nitro-1,1-ethenediamine and 4,6-dinitro-1,3-benzenediamine, with compound 8 demonstrating activity greater than physostigmine. 4,6-dinitrobenzene-1,3-diamine 101-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 1552502-4 1992 The most active AChE inhibitors were N,N"-disubstituted derivatives of 2-nitro-1,1-ethenediamine and 4,6-dinitro-1,3-benzenediamine, with compound 8 demonstrating activity greater than physostigmine. Physostigmine 185-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 1547059-0 1992 Effects of neostigmine and edrophonium on human erythrocyte acetylcholinesterase activity. Neostigmine 11-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 1547059-0 1992 Effects of neostigmine and edrophonium on human erythrocyte acetylcholinesterase activity. Edrophonium 27-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 1547059-1 1992 Erythrocyte acetylcholinesterase (AChE) activities in vivo were measured over 60 min using a spectrophotometric method after administration of neostigmine or edrophonium for antagonism of pancuronium-induced neuromuscular block in 31 patients. Edrophonium 158-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 1547059-1 1992 Erythrocyte acetylcholinesterase (AChE) activities in vivo were measured over 60 min using a spectrophotometric method after administration of neostigmine or edrophonium for antagonism of pancuronium-induced neuromuscular block in 31 patients. Edrophonium 158-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 1547059-2 1992 Erythrocyte AChE activities decreased to 11.3 (SD 1.2)% and 11.4 (0.8)% of baseline values (P less than 0.001) within 2 min, then recovered slowly and were 43.2 (6.2)% and 27.9 (2.9)% (P less than 0.001) 60 min after administration of neostigmine 0.036 mg kg-1 and 0.071 mg kg-1, respectively. Neostigmine 235-246 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-16 1547059-4 1992 The results suggest that mechanisms other than AChE inhibition may be responsible for the anti-curare effect of edrophonium. Edrophonium 112-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 1552180-0 1992 A one-step cobalt-ferrocyanide method for histochemical demonstration of acetylcholinesterase activity in central nervous system tissue. cobalt-ferrocyanide 11-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 1552180-1 1992 We introduce a one-step histochemical method with cobalt as the precipitating agent for ferrocyanide for the light microscopic demonstration of acetylcholinesterase activity. Cobalt 50-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-164 1552180-1 1992 We introduce a one-step histochemical method with cobalt as the precipitating agent for ferrocyanide for the light microscopic demonstration of acetylcholinesterase activity. hexacyanoferrate II 88-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-164 1540236-6 1992 One choline ester-hydrolysing enzyme was identified as acetylcholinesterase (EC 3.1.1.7), and one as butyrylcholinesterase (EC 3.1.1.8). choline ester 4-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 1346558-1 1992 In the last decade, pyridostigmine, a quaternary carbamate that reversibly inhibits the enzyme acetylcholinesterase, was proposed for pretreatment of nerve gas (organophosphate) poisoning. Pyridostigmine Bromide 20-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 1346558-1 1992 In the last decade, pyridostigmine, a quaternary carbamate that reversibly inhibits the enzyme acetylcholinesterase, was proposed for pretreatment of nerve gas (organophosphate) poisoning. quaternary carbamate 38-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 1346558-1 1992 In the last decade, pyridostigmine, a quaternary carbamate that reversibly inhibits the enzyme acetylcholinesterase, was proposed for pretreatment of nerve gas (organophosphate) poisoning. Organophosphates 161-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 1735432-2 1992 Two para-dialkylaminobenzenediazonium salts, the dimethylamino (A) and dibutylamino (B) derivatives, are presented as structural probes for acetylcholinesterase and butyrylcholinesterase. para-dialkylaminobenzenediazonium salts 4-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-160 1735432-2 1992 Two para-dialkylaminobenzenediazonium salts, the dimethylamino (A) and dibutylamino (B) derivatives, are presented as structural probes for acetylcholinesterase and butyrylcholinesterase. Dimethyl amidogen 49-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-160 1735432-2 1992 Two para-dialkylaminobenzenediazonium salts, the dimethylamino (A) and dibutylamino (B) derivatives, are presented as structural probes for acetylcholinesterase and butyrylcholinesterase. dibutylamino 71-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-160 1735432-5 1992 Moreover, in the case of acetylcholinesterase, protection experiments with specific ligands (edrophonium and propidium) showed that the dimethylamino salt A exclusively labels the hydrolytic anionic site, whereas the dibutylamino salt B also labels the peripheral site. dimethylamino salt a 136-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 1735432-5 1992 Moreover, in the case of acetylcholinesterase, protection experiments with specific ligands (edrophonium and propidium) showed that the dimethylamino salt A exclusively labels the hydrolytic anionic site, whereas the dibutylamino salt B also labels the peripheral site. dibutylamino salt b 217-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 1729389-2 1992 Addition of either atropine or tubocurarine in the presence of the acetylcholinesterase inhibitor phospholine iodide enhanced acetylcholine release. Atropine 19-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 1729389-2 1992 Addition of either atropine or tubocurarine in the presence of the acetylcholinesterase inhibitor phospholine iodide enhanced acetylcholine release. Tubocurarine 31-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 1729389-2 1992 Addition of either atropine or tubocurarine in the presence of the acetylcholinesterase inhibitor phospholine iodide enhanced acetylcholine release. Echothiophate Iodide 98-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 1320213-9 1992 Acetylcholine (100 microM) plus eserine (50 microM) and BW284c55 (1 microM), an acetylcholinesterase inhibitor, reduced the binding of QNB by approximately 25%. Acetylcholine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 1320213-9 1992 Acetylcholine (100 microM) plus eserine (50 microM) and BW284c55 (1 microM), an acetylcholinesterase inhibitor, reduced the binding of QNB by approximately 25%. bw284c55 56-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 1320213-9 1992 Acetylcholine (100 microM) plus eserine (50 microM) and BW284c55 (1 microM), an acetylcholinesterase inhibitor, reduced the binding of QNB by approximately 25%. Quinuclidinyl Benzilate 135-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 1628449-3 1992 AchE activity was evaluated according to Ellman"s method using acetylthiocholine iodide as a substrate and tetraisopropyl-pyrophosphoramide, a specific inhibitor of butyrylocholinesterase. acetylthiocholine iodide 63-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 1628449-3 1992 AchE activity was evaluated according to Ellman"s method using acetylthiocholine iodide as a substrate and tetraisopropyl-pyrophosphoramide, a specific inhibitor of butyrylocholinesterase. Tetraisopropylpyrophosphamide 107-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 1349516-2 1992 Amniotic fluid cholinesterases (mixture of acetylcholinesterase and butyrylcholinesterase) purified by procainamide-Sepharose affinity chromatography exhibited aryl acylamidase activity which was sensitive to serotonin inhibition (a property of aryl acylamidases associated with both acetyl- and butyrylcholinesterases) and tyramine activation (shown exclusively by aryl acylamidase associated with butyrylcholinesterase). Procainamide 103-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 1349516-2 1992 Amniotic fluid cholinesterases (mixture of acetylcholinesterase and butyrylcholinesterase) purified by procainamide-Sepharose affinity chromatography exhibited aryl acylamidase activity which was sensitive to serotonin inhibition (a property of aryl acylamidases associated with both acetyl- and butyrylcholinesterases) and tyramine activation (shown exclusively by aryl acylamidase associated with butyrylcholinesterase). Sepharose 116-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 1349516-2 1992 Amniotic fluid cholinesterases (mixture of acetylcholinesterase and butyrylcholinesterase) purified by procainamide-Sepharose affinity chromatography exhibited aryl acylamidase activity which was sensitive to serotonin inhibition (a property of aryl acylamidases associated with both acetyl- and butyrylcholinesterases) and tyramine activation (shown exclusively by aryl acylamidase associated with butyrylcholinesterase). Serotonin 209-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 1349516-2 1992 Amniotic fluid cholinesterases (mixture of acetylcholinesterase and butyrylcholinesterase) purified by procainamide-Sepharose affinity chromatography exhibited aryl acylamidase activity which was sensitive to serotonin inhibition (a property of aryl acylamidases associated with both acetyl- and butyrylcholinesterases) and tyramine activation (shown exclusively by aryl acylamidase associated with butyrylcholinesterase). Tyramine 324-332 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 1349516-3 1992 Tyramine activation was unaffected in the presence of the selective acetylcholinesterase inhibitor BW284C51 whereas it was abolished in the presence of the selective butyrylcholinesterase inhibitor ethopropazine, suggesting the presence of both types of aryl acylamidases in amniotic fluid, one associated with acetylcholinesterase and the other associated with butyrylcholinesterase. Tyramine 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 311-331 1738152-0 1992 Conformational analyses and molecular-shape comparisons of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase. indanone-benzylpiperidine 71-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 1738152-1 1992 Conformational analyses and molecular-shape comparisons were carried out on an analogue series of indanone-benzylpiperidine inhibitors of acetylcholinesterase (AChE). indanone-benzylpiperidine 98-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 1738152-1 1992 Conformational analyses and molecular-shape comparisons were carried out on an analogue series of indanone-benzylpiperidine inhibitors of acetylcholinesterase (AChE). indanone-benzylpiperidine 98-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 1738152-5 1992 The postulated active conformation for 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride (1a), a potent AChE inhibitor, is close to the crystal structures of 1a with respect to the indanone-piperidine substructure, but differs from the crystal structures for the benzylpiperidine moiety. 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride 39-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 1738152-6 1992 However, the crystal conformations and the postulated active conformation of the benzylpiperidine portion of the AChE inhibitor are estimated to be about equally stable. 1-benzylpiperidine 81-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 1538717-0 1992 Interaction of tetrahydroaminoacridine with acetylcholinesterase and butyrylcholinesterase. Tacrine 15-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 1538717-1 1992 This paper examines inhibition of acetylcholinesterase (AchE) and butyrylcholinesterase (BuchE) by tetrahydroaminoacridine (THA), an acridine analog under consideration for palliative treatment of Alzheimer"s dementia. Tacrine 99-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 1538717-1 1992 This paper examines inhibition of acetylcholinesterase (AchE) and butyrylcholinesterase (BuchE) by tetrahydroaminoacridine (THA), an acridine analog under consideration for palliative treatment of Alzheimer"s dementia. Tacrine 99-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 1538717-1 1992 This paper examines inhibition of acetylcholinesterase (AchE) and butyrylcholinesterase (BuchE) by tetrahydroaminoacridine (THA), an acridine analog under consideration for palliative treatment of Alzheimer"s dementia. Tacrine 124-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 1538717-1 1992 This paper examines inhibition of acetylcholinesterase (AchE) and butyrylcholinesterase (BuchE) by tetrahydroaminoacridine (THA), an acridine analog under consideration for palliative treatment of Alzheimer"s dementia. Tacrine 124-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 1538717-1 1992 This paper examines inhibition of acetylcholinesterase (AchE) and butyrylcholinesterase (BuchE) by tetrahydroaminoacridine (THA), an acridine analog under consideration for palliative treatment of Alzheimer"s dementia. Acridines 114-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 1538717-1 1992 This paper examines inhibition of acetylcholinesterase (AchE) and butyrylcholinesterase (BuchE) by tetrahydroaminoacridine (THA), an acridine analog under consideration for palliative treatment of Alzheimer"s dementia. Acridines 114-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 1538717-2 1992 THA causes linear mixed inhibition of AchE hydrolysis of acetylthiocholine, a cationic substrate (KI = 3.8 x 10(-9) M), and linear competitive inhibition of AchE hydrolysis of 7-acetoxy-4-methylcoumarin, an uncharged substrate (KI = 6.8 x 10(-9) M), and N-methyl-7-dimethylcarbamoxyquinolinium, a cationic carbamate (KI = 1.5 x 10(-8) M). Tacrine 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 1538717-2 1992 THA causes linear mixed inhibition of AchE hydrolysis of acetylthiocholine, a cationic substrate (KI = 3.8 x 10(-9) M), and linear competitive inhibition of AchE hydrolysis of 7-acetoxy-4-methylcoumarin, an uncharged substrate (KI = 6.8 x 10(-9) M), and N-methyl-7-dimethylcarbamoxyquinolinium, a cationic carbamate (KI = 1.5 x 10(-8) M). Tacrine 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 1538717-2 1992 THA causes linear mixed inhibition of AchE hydrolysis of acetylthiocholine, a cationic substrate (KI = 3.8 x 10(-9) M), and linear competitive inhibition of AchE hydrolysis of 7-acetoxy-4-methylcoumarin, an uncharged substrate (KI = 6.8 x 10(-9) M), and N-methyl-7-dimethylcarbamoxyquinolinium, a cationic carbamate (KI = 1.5 x 10(-8) M). Acetylthiocholine 57-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 1538717-2 1992 THA causes linear mixed inhibition of AchE hydrolysis of acetylthiocholine, a cationic substrate (KI = 3.8 x 10(-9) M), and linear competitive inhibition of AchE hydrolysis of 7-acetoxy-4-methylcoumarin, an uncharged substrate (KI = 6.8 x 10(-9) M), and N-methyl-7-dimethylcarbamoxyquinolinium, a cationic carbamate (KI = 1.5 x 10(-8) M). 4-methylumbelliferyl acetate 176-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 1538717-3 1992 Propidium association with AchE in the presence of saturating concentrations of THA is characterized by a dissociation constant of 7.7 +/- 0.7 x 10(-6) M, a value within 2-fold of the dissociation constant in the absence of THA. Propidium 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 1538717-3 1992 Propidium association with AchE in the presence of saturating concentrations of THA is characterized by a dissociation constant of 7.7 +/- 0.7 x 10(-6) M, a value within 2-fold of the dissociation constant in the absence of THA. Tacrine 80-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 1538717-4 1992 Association of THA with AchE is, therefore, not mutually exclusive with association of propidium at the peripheral anionic site. Tacrine 15-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 1538717-5 1992 Moreover, THA causes dissociation of decidium complexes with AchE at concentrations compatible with a dissociation constant of 7.0 +/- 0.4 x 10(-9) M. Similar relationships were observed for THA inhibition of BuchE hydrolysis of butyrylthiocholine (KI = 2.5 x 10(-8) M) and dissociation of decidium complexes with BuchE (KD = 1.9 +/- 0.1 x 10(-8) M). Tacrine 10-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 1538717-5 1992 Moreover, THA causes dissociation of decidium complexes with AchE at concentrations compatible with a dissociation constant of 7.0 +/- 0.4 x 10(-9) M. Similar relationships were observed for THA inhibition of BuchE hydrolysis of butyrylthiocholine (KI = 2.5 x 10(-8) M) and dissociation of decidium complexes with BuchE (KD = 1.9 +/- 0.1 x 10(-8) M). decidium 37-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 1538717-5 1992 Moreover, THA causes dissociation of decidium complexes with AchE at concentrations compatible with a dissociation constant of 7.0 +/- 0.4 x 10(-9) M. Similar relationships were observed for THA inhibition of BuchE hydrolysis of butyrylthiocholine (KI = 2.5 x 10(-8) M) and dissociation of decidium complexes with BuchE (KD = 1.9 +/- 0.1 x 10(-8) M). Butyrylthiocholine 229-247 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 1538717-5 1992 Moreover, THA causes dissociation of decidium complexes with AchE at concentrations compatible with a dissociation constant of 7.0 +/- 0.4 x 10(-9) M. Similar relationships were observed for THA inhibition of BuchE hydrolysis of butyrylthiocholine (KI = 2.5 x 10(-8) M) and dissociation of decidium complexes with BuchE (KD = 1.9 +/- 0.1 x 10(-8) M). decidium 290-298 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 1595894-1 1992 A flow injection system, incorporating an acetylcholinesterase (AChE) single bead string reactor (SBSR), for the determination of some organophosphorous (azinphos-ethyl, azinphos-methyl, bromophos-methyl, dichlorovos, fenitrothion, malathion, paraoxon, parathion-ethyl and parathion-methyl) and carbamate insecticides (carbofuran and carbaryl) is presented. organophosphorous 135-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 1510740-3 1992 To explore the physiological importance of these findings, we have examined the impact of RFR exposure on a membrane-bound enzyme, acetylcholinesterase (AChE), which is intimately involved with the acetylcholine (ACh) neurotransmitter system. Acetylcholine 131-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 1510740-3 1992 To explore the physiological importance of these findings, we have examined the impact of RFR exposure on a membrane-bound enzyme, acetylcholinesterase (AChE), which is intimately involved with the acetylcholine (ACh) neurotransmitter system. Acetylcholine 153-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-151 1510740-4 1992 Neuroblastoma cells (NG108), exposed for 30 min to 147-MHz radiation, AM at 16 Hz, demonstrated enhanced AChE activity, as assayed by a procedure using 14C-labeled ACh. Carbon-14 152-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 1563457-2 1992 In this study, the Ch4 of the nbM was examined using the indirect immunoperoxidase method with a monoclonal antibody to acetylcholinesterase (AChE) counterstained with cresyl violet. cresyl violet 168-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 1563457-2 1992 In this study, the Ch4 of the nbM was examined using the indirect immunoperoxidase method with a monoclonal antibody to acetylcholinesterase (AChE) counterstained with cresyl violet. cresyl violet 168-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 1388703-2 1992 Acetylcholinesterase (AChE), an enzyme responsible for the break-down of acetylcholine, is found both in cholinergic and non-cholinergic neurons in the central nervous system. Acetylcholine 73-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 1388703-3 1992 In addition to its role in the catabolism of acetylcholine, AChE have other functions in brain, e.g. in the processing of peptides and proteins, and in the modulation of dopaminergic neurons in the brain stem. Acetylcholine 45-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 1635444-0 1992 [Acetylcholinesterase activity in erythrocytes of workers engaged in the production of iron-manganese alloys]. Iron 87-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 1-21 1635444-0 1992 [Acetylcholinesterase activity in erythrocytes of workers engaged in the production of iron-manganese alloys]. Manganese 92-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 1-21 1635444-1 1992 The activity of acetylcholinesterase in the red blood cells of metallurgy workers producing iron-manganese alloys was statistically less significant than the activity of this enzyme in the control group. Iron 92-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 1635444-1 1992 The activity of acetylcholinesterase in the red blood cells of metallurgy workers producing iron-manganese alloys was statistically less significant than the activity of this enzyme in the control group. Manganese 97-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 1436206-8 1992 Exogenous ACh (20 nmol/l) applied simultaneously with inhibitor of AChE partially prevented the shortening of MEPCs decay, but decreased the amplitude of MEPC. Acetylcholine 10-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 1311432-2 1992 Results document the important role(s) of functional AChRs and ACh-AChR interactions in the differential control of individual AChE isoenzymes. Acetylcholine 53-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 1738756-0 1992 Influence of cetiedil on erythrocyte membrane microviscosity and acetylcholinesterase activity. cetiedil 13-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 1738756-3 1992 Cetiedil, however, did lower acetylcholinesterase activity, but it did not directly inhibit this enzyme activity. cetiedil 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 1410128-0 1992 Effects of a single dose of the acetylcholinesterase inhibitor velnacrine on recognition memory and regional cerebral blood flow in Alzheimer"s disease. velnacrine 63-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 1410689-1 1992 The bases of using blood enzyme activity measurements [e.g. AChE, non-specific cholinesterase (BChE), carboxylesterase] as markers of organophosphate ester (OP) exposure are inhibition of activity by the binding of OPs to serine active sites in the enzymes, and the accessibility of the enzymes in RBCs and serum. organophosphate ester 134-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 1733041-0 1992 Central activity of acetylcholinesterase oxime reactivators. Oximes 41-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 1733041-1 1992 The ability of various oximes to antagonize the sarin-induced hypothermia and reactivate phosphorylated acetylcholinesterase was used as an indicator of the central activity of oximes. Oximes 23-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 1733041-2 1992 HI-6, but neither toxogonin nor PAM Cl, antagonized sarin-induced hypothermia and reactivated brain acetylcholinesterase, in particular hypothalamic acetylcholinesterase. asoxime chloride 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 1733041-2 1992 HI-6, but neither toxogonin nor PAM Cl, antagonized sarin-induced hypothermia and reactivated brain acetylcholinesterase, in particular hypothalamic acetylcholinesterase. asoxime chloride 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-169 1777989-3 1991 Acetylcholine or butyrylcholine, in the presence of samples containing acetylcholinesterase or butyrylcholinesterase are specifically hydrolyzed, the formation of choline being detected vs time by the sensor with no need for a selective inhibitor. Acetylcholine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 1777989-3 1991 Acetylcholine or butyrylcholine, in the presence of samples containing acetylcholinesterase or butyrylcholinesterase are specifically hydrolyzed, the formation of choline being detected vs time by the sensor with no need for a selective inhibitor. butyrylcholine 17-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 1777989-3 1991 Acetylcholine or butyrylcholine, in the presence of samples containing acetylcholinesterase or butyrylcholinesterase are specifically hydrolyzed, the formation of choline being detected vs time by the sensor with no need for a selective inhibitor. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 1748670-0 1991 The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Disulfides 42-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 1748670-2 1991 Site-directed mutagenesis was used to study the cysteine residue involved in the assembly of human acetylcholinesterase (HuAChE) catalytic subunits. Cysteine 48-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 1814616-2 1991 Potent acetylcholinesterase inhibitors, 2-[omega-[N-alkyl-N-(omega-phenyl-alkyl)amino]alkyl]-1H-isoindole- 1,3(2H)-diones, based on a new hypothesis of the enzyme"s active site. 2-[omega-[n-alkyl-n-(omega-phenyl-alkyl)amino]alkyl]-1h-isoindole- 1,3(2h)-diones 40-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 7-27 1814616-6 1991 A series of 2-[omega-[N-alkyl-N-(omega-phenyl-alkyl)amino]alkyl]-1H- isoindole-1,3(2H)-diones was designed based on this hypothesis and tested for its inhibitory activities on acetylcholinesterase. 2-[omega-[n-alkyl-n-(omega-phenyl-alkyl)amino]alkyl]-1h- isoindole-1,3(2h)-diones 12-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-196 1814617-2 1991 Synthesis and acetylcholinesterase inhibitory activities of N-[omega-[N-alkyl-N-(phenylmethyl)amino]alkyl]-3-arylpropenamides. n-[omega-[n-alkyl-n-(phenylmethyl)amino]alkyl]-3-arylpropenamides 60-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 1814617-3 1991 A series of N-[omega-[N-alkyl-N-(phenylmethyl)amino]alkyl]-3-arylpropenamides was prepared and tested for its inhibitory activities on acetylcholinesterase. n-[omega-[n-alkyl-n-(phenylmethyl)amino]alkyl]-3-arylpropenamides 12-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 1820094-1 1991 Hydrolysis of the neurotransmitter acetylcholine by acetylcholinesterase (ACHE) and butyrylcholinesterase (BCHE) is the rate-limiting step in the termination of cholinergic signaling at neuromuscular junctions. Acetylcholine 35-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 1766006-0 1991 Delineating the pharmacophoric elements of huperzine A: importance of the unsaturated three-carbon bridge to its AChE inhibitory activity. huperzine A 43-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 1757241-1 1991 Pyridostigmine bromide, a reversible inhibitor of acetylcholinesterase (AChE), is effectively used as a pre-treatment to organophosphate intoxication. Pyridostigmine Bromide 0-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 1757241-1 1991 Pyridostigmine bromide, a reversible inhibitor of acetylcholinesterase (AChE), is effectively used as a pre-treatment to organophosphate intoxication. Organophosphates 121-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 1654884-1 1991 Membrane-bound acetylcholinesterase (AChE) from the human erythrocyte is inhibited by chlorpromazine (CPZ) in a concentration range within this amphiphilic drug has been demonstrated to interact with erythrocyte membranes, causing a large spectrum of physical and structural effects; membrane solubilization with 0.5% Triton X-100 results in a complete loss of CPZ inhibitory potency. Chlorpromazine 86-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 1787292-2 1991 Although refractory to precordial thump, synchronous cardioversion, and lidocaine, the ventricular tachycardia was reversed by intravenous administration of the tertiary acetylcholinesterase inhibitor physostigmine. Physostigmine 201-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-190 1914378-5 1991 The inhibition of acetylcholinesterase activity was closely correlated with the pharmacokinetics of galanthamine, a median maximal value of 53% being achieved by applying 10 mg galanthamine intravenously. Galantamine 100-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 1914378-5 1991 The inhibition of acetylcholinesterase activity was closely correlated with the pharmacokinetics of galanthamine, a median maximal value of 53% being achieved by applying 10 mg galanthamine intravenously. Galantamine 177-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 1892865-0 1991 A wavelength dependent mechanism for rose bengal-sensitized photoinhibition of red cell acetylcholinesterase. Rose Bengal 37-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 1892865-1 1991 A 2-fold enhancement in the efficiency of rose bengal-photosensitized inhibition of red cell acetylcholinesterase activity was observed upon excitation of the dye in the ultraviolet (UV) (313 nm) compared to irradiation in the visible (514 or 550 nm). Rose Bengal 42-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 1654884-1 1991 Membrane-bound acetylcholinesterase (AChE) from the human erythrocyte is inhibited by chlorpromazine (CPZ) in a concentration range within this amphiphilic drug has been demonstrated to interact with erythrocyte membranes, causing a large spectrum of physical and structural effects; membrane solubilization with 0.5% Triton X-100 results in a complete loss of CPZ inhibitory potency. Chlorpromazine 102-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 1654884-1 1991 Membrane-bound acetylcholinesterase (AChE) from the human erythrocyte is inhibited by chlorpromazine (CPZ) in a concentration range within this amphiphilic drug has been demonstrated to interact with erythrocyte membranes, causing a large spectrum of physical and structural effects; membrane solubilization with 0.5% Triton X-100 results in a complete loss of CPZ inhibitory potency. Chlorpromazine 102-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 1654884-1 1991 Membrane-bound acetylcholinesterase (AChE) from the human erythrocyte is inhibited by chlorpromazine (CPZ) in a concentration range within this amphiphilic drug has been demonstrated to interact with erythrocyte membranes, causing a large spectrum of physical and structural effects; membrane solubilization with 0.5% Triton X-100 results in a complete loss of CPZ inhibitory potency. Octoxynol 318-330 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 1654884-1 1991 Membrane-bound acetylcholinesterase (AChE) from the human erythrocyte is inhibited by chlorpromazine (CPZ) in a concentration range within this amphiphilic drug has been demonstrated to interact with erythrocyte membranes, causing a large spectrum of physical and structural effects; membrane solubilization with 0.5% Triton X-100 results in a complete loss of CPZ inhibitory potency. Octoxynol 318-330 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 1654884-3 1991 These results demonstrate unequivocally that CPZ inhibits human erythrocyte AChE through direct molecular interaction. Chlorpromazine 45-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 1654884-4 1991 The inhibition kinetics displayed by CPZ on human erythrocyte AChE are dependent on drug concentration: evidence is provided that this phenomenon may be related to formation of CPZ micellar aggregates. Chlorpromazine 37-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 1654884-4 1991 The inhibition kinetics displayed by CPZ on human erythrocyte AChE are dependent on drug concentration: evidence is provided that this phenomenon may be related to formation of CPZ micellar aggregates. Chlorpromazine 177-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 1890690-5 1991 In addition, 4-nitrophenyl chloromethyl(phenyl)phosphinate (CPMP) inhibition of eel AChE on average was nearly 10-fold greater than FBS AChE and three orders of magnitude greater than BCN AChE. 4-nitrophenyl chloromethyl(phenyl)phosphinate 13-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 1890690-5 1991 In addition, 4-nitrophenyl chloromethyl(phenyl)phosphinate (CPMP) inhibition of eel AChE on average was nearly 10-fold greater than FBS AChE and three orders of magnitude greater than BCN AChE. nulibry 60-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 1890690-6 1991 The oxime HI-6 reactivated soman phosphonylated enzymes to a considerably greater extent than other oximes, and FBS AChE was notably more responsive to HI-6 than to other oximes. asoxime chloride 152-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 1890690-6 1991 The oxime HI-6 reactivated soman phosphonylated enzymes to a considerably greater extent than other oximes, and FBS AChE was notably more responsive to HI-6 than to other oximes. Oximes 171-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 1890690-7 1991 The individual mean values of the ki for each inhibitor in each class (phosphonate or phosphinate) were different with respect to each AChE, which may be a reflection of differences in enzyme configuration, whereas the general rank order of inhibitor potency within each class, reflected by the ki, was similar with respect to each AChE, which may be related to similar active centers. Organophosphonates 71-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 1890690-7 1991 The individual mean values of the ki for each inhibitor in each class (phosphonate or phosphinate) were different with respect to each AChE, which may be a reflection of differences in enzyme configuration, whereas the general rank order of inhibitor potency within each class, reflected by the ki, was similar with respect to each AChE, which may be related to similar active centers. phosphinate 86-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 1890690-8 1991 In general, oxime potency and some rank order varied with each inhibitor and with each AChE, although there was some similarity in oxime rank order between the two mammalian AChEs. Oximes 12-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 1858789-3 1991 We recently treated 18 Alzheimer disease patients with metrifonate, a long-acting AChE inhibitor, over periods up to 7 months, with resulting erythrocyte AChE inhibition as high as 82 per cent of baseline values. Trichlorfon 55-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 1955905-6 1991 These data suggest that the doses of physostigmine used were insufficient to produce marked inhibition of AChE within the central nervous system. Physostigmine 37-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 1858789-3 1991 We recently treated 18 Alzheimer disease patients with metrifonate, a long-acting AChE inhibitor, over periods up to 7 months, with resulting erythrocyte AChE inhibition as high as 82 per cent of baseline values. Trichlorfon 55-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-158 1842792-6 1991 Studies of the in vitro inhibition of acetylcholinesterase (AChE) activity by carbaryl demonstrated that there was no difference between males and females of a given strain and that the R strain AChE was considerably less sensitive to inhibition. Carbaryl 78-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 1663710-0 1991 A silica gel plate-based qualitative assay for acetylcholinesterase activity: a mass method to screen for potential inhibitors. Silica Gel 2-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 1663710-3 1991 The silica gel plate is sprayed with a solution of acetylthiocholine iodide and 5,5-dithiobis(2-nitrobenzoic acid) followed by a solution of acetylcholinesterase. Silica Gel 4-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 1954303-0 1991 Inhibition of acetylcholinesterase activity in human brain tissue and erythrocytes by galanthamine, physostigmine and tacrine. Galantamine 86-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 1954303-0 1991 Inhibition of acetylcholinesterase activity in human brain tissue and erythrocytes by galanthamine, physostigmine and tacrine. Physostigmine 100-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 1954303-0 1991 Inhibition of acetylcholinesterase activity in human brain tissue and erythrocytes by galanthamine, physostigmine and tacrine. Tacrine 118-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 1954303-1 1991 Galanthamine, physostigmine and 9-amino-1,2,3,4-tetrahydroacridine (tacrine) were evaluated as inhibitors of human acetylcholinesterase activity from samples of postmortem human brain, fresh brain cortex biopsies and human erythrocytes. Tacrine 32-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 1954303-2 1991 Acetylcholinesterase activity was most effectively inhibited in all tissues by physostigmine, followed by tacrine and galanthamine. Physostigmine 79-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 1954303-2 1991 Acetylcholinesterase activity was most effectively inhibited in all tissues by physostigmine, followed by tacrine and galanthamine. Tacrine 106-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 1954303-2 1991 Acetylcholinesterase activity was most effectively inhibited in all tissues by physostigmine, followed by tacrine and galanthamine. Galantamine 118-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 1954303-4 1991 In addition, the inhibition of acetylcholinesterase by galanthamine was similar in postmortem brain and brain cortical biopsies from patients submitted to brain-tumour removal, indicating that postmortem changes up to 28 h after death probably did not influence the measurement of acetylcholinesterase inhibition. Galantamine 55-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 1954303-5 1991 While physostigmine and tacrine acted equally on acetylcholinesterase from different sources, galanthamine was 10-fold less potent in inhibiting the enzyme activity from human brain that from human erythrocytes. Physostigmine 6-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 1954303-5 1991 While physostigmine and tacrine acted equally on acetylcholinesterase from different sources, galanthamine was 10-fold less potent in inhibiting the enzyme activity from human brain that from human erythrocytes. Tacrine 24-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 1842792-6 1991 Studies of the in vitro inhibition of acetylcholinesterase (AChE) activity by carbaryl demonstrated that there was no difference between males and females of a given strain and that the R strain AChE was considerably less sensitive to inhibition. Carbaryl 78-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 1907148-4 1991 Control values for red cell acetylcholinesterase (AChE) activity (mumol/min/mL blood) using acetylthiocholine (1 mM) were higher in the human (4.98) and the rhesus monkey (4.14) than in the marmoset (0.84) and the guinea-pig (0.83). Acetylthiocholine 92-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 1907148-4 1991 Control values for red cell acetylcholinesterase (AChE) activity (mumol/min/mL blood) using acetylthiocholine (1 mM) were higher in the human (4.98) and the rhesus monkey (4.14) than in the marmoset (0.84) and the guinea-pig (0.83). Acetylthiocholine 92-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 1907148-7 1991 The rate of recovery of red cell AChE and plasma ChE activities, following incubation of whole blood with physostigmine (1 x 10(-7) M), was in the order human greater than rhesus monkey greater than marmoset greater than guinea-pig. Physostigmine 106-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 1895153-0 1991 Determination of erythrocyte-bound acetylcholinesterase activity for monitoring pyridostigmine therapy in myasthenia gravis. Pyridostigmine Bromide 80-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 1913783-0 1991 Calcium and ionophore A23187 stimulates deposition of extracellular matrix and acetylcholinesterase release in cultured myotubes. Calcium 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 1913783-0 1991 Calcium and ionophore A23187 stimulates deposition of extracellular matrix and acetylcholinesterase release in cultured myotubes. Calcimycin 22-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 1913783-2 1991 We demonstrate here than increases in intracellular calcium concentration induce a time- and concentration-dependent deposition of extracellular matrix and an increase in acetylcholinesterase secretion. Calcium 52-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-191 1913783-3 1991 Scanning and transmission electron-microscopy revealed that treatment with the calcium ionophore A23187, or high extracellular Ca2+ levels (5 mM to 15 mM) produce significant deposits of extracellular matrix around the myotubes, as well as a marked increase in the acetylcholinesterase reaction-product. Calcium 79-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 265-285 1913783-3 1991 Scanning and transmission electron-microscopy revealed that treatment with the calcium ionophore A23187, or high extracellular Ca2+ levels (5 mM to 15 mM) produce significant deposits of extracellular matrix around the myotubes, as well as a marked increase in the acetylcholinesterase reaction-product. Calcimycin 97-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 265-285 1913783-5 1991 Sucrose density-gradients of media conditioned by muscle cells revealed 3 separate acetylcholinesterase molecular forms. Sucrose 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 1906943-3 1991 Optimum conditions for the cerebellar AChE activity were determined with respect to molarity of the buffer, pH, temperature, and concentrations of substrate (acetylthiocholine iodide), activators (NaCl, MgCl2), and thiol indicator (dithiobisnitrobenzoic acid). acetylthiocholine iodide 158-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 1906943-3 1991 Optimum conditions for the cerebellar AChE activity were determined with respect to molarity of the buffer, pH, temperature, and concentrations of substrate (acetylthiocholine iodide), activators (NaCl, MgCl2), and thiol indicator (dithiobisnitrobenzoic acid). Sodium Chloride 197-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 1906943-3 1991 Optimum conditions for the cerebellar AChE activity were determined with respect to molarity of the buffer, pH, temperature, and concentrations of substrate (acetylthiocholine iodide), activators (NaCl, MgCl2), and thiol indicator (dithiobisnitrobenzoic acid). Magnesium Chloride 203-208 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 1906943-3 1991 Optimum conditions for the cerebellar AChE activity were determined with respect to molarity of the buffer, pH, temperature, and concentrations of substrate (acetylthiocholine iodide), activators (NaCl, MgCl2), and thiol indicator (dithiobisnitrobenzoic acid). Sulfhydryl Compounds 215-220 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 1906943-3 1991 Optimum conditions for the cerebellar AChE activity were determined with respect to molarity of the buffer, pH, temperature, and concentrations of substrate (acetylthiocholine iodide), activators (NaCl, MgCl2), and thiol indicator (dithiobisnitrobenzoic acid). Dithionitrobenzoic Acid 232-258 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 1906943-4 1991 In vitro inhibition of cerebellar AChE with two commercial pesticides, Metacid-50 (O,O-dimethyl p-nitrophenyl phosphorothioate) and carbaryl (N-methyl naphthyl-1-carbamate), were compared with pure anticholinesterase agents, diisopropylfluorophosphate (DFP) and physostigmine (eserine). Methyl Parathion 71-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 1906943-5 1991 In general, organophosphates are more neurotoxic than carbamate compounds, as evidenced by higher degree of AChE inhibition by DFP and Metacid-50 as compared to eserine and carbaryl. Organophosphates 12-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 1906943-5 1991 In general, organophosphates are more neurotoxic than carbamate compounds, as evidenced by higher degree of AChE inhibition by DFP and Metacid-50 as compared to eserine and carbaryl. Isoflurophate 127-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 1906943-5 1991 In general, organophosphates are more neurotoxic than carbamate compounds, as evidenced by higher degree of AChE inhibition by DFP and Metacid-50 as compared to eserine and carbaryl. Methyl Parathion 135-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 1906943-6 1991 Assays were also done with psychotropic drugs by employing the procedure of in vitro AChE inhibition kinetics, and it was found that psychotropic drugs are less potent than organophosphate and carbamate compounds. Organophosphates 173-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 1906943-6 1991 Assays were also done with psychotropic drugs by employing the procedure of in vitro AChE inhibition kinetics, and it was found that psychotropic drugs are less potent than organophosphate and carbamate compounds. Carbamates 193-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 1906943-7 1991 Results indicate that pure and commercial organophosphates and carbamates and psychotropic drugs are all able to significantly alter the AChE activity. Organophosphates 42-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 1906943-7 1991 Results indicate that pure and commercial organophosphates and carbamates and psychotropic drugs are all able to significantly alter the AChE activity. Carbamates 63-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 2039553-1 1991 (-)-ketamine was found to be more potent than (+)-ketamine in all the studied reactions with acetylcholinesterase. Ketamine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 2039553-1 1991 (-)-ketamine was found to be more potent than (+)-ketamine in all the studied reactions with acetylcholinesterase. Ketamine 46-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 2048762-9 1991 In humans, exposure to the acetylcholinesterase inhibitor, Aldicarb, was received through contaminated well water. Aldicarb 59-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 2048762-9 1991 In humans, exposure to the acetylcholinesterase inhibitor, Aldicarb, was received through contaminated well water. Water 108-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 2040291-5 1991 Enzyme-linked immunosorbent assay and Western blot showed that heat-denatured, diisopropylfluorophosphate-treated, CNBr- and trypsin-digested AChE from T. marmorata still reacted with mAb 2G8; this indicates that the epitope to which 2G8 bound, at least partially, belonged to a continuous determinant. Isoflurophate 79-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 1654884-0 1991 A study of human erythrocyte acetylcholinesterase inhibition by chlorpromazine. Chlorpromazine 64-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 1654884-1 1991 Membrane-bound acetylcholinesterase (AChE) from the human erythrocyte is inhibited by chlorpromazine (CPZ) in a concentration range within this amphiphilic drug has been demonstrated to interact with erythrocyte membranes, causing a large spectrum of physical and structural effects; membrane solubilization with 0.5% Triton X-100 results in a complete loss of CPZ inhibitory potency. Chlorpromazine 86-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 2036344-3 1991 Polyacrylamide gel electrophoresis revealed that the enzyme of ocular fluid had the same mobility as that of acetylcholinesterase from cerebrospinal fluid. polyacrylamide 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-129 1909249-1 1991 An optical sensor for anticholinesterases (AntiChEs) was constructed by immobilizing fluorescein isothiocyanate (FITC)-tagged eel electric organ acetylcholinesterase (AChE) on quartz fibers and monitoring enzyme activity. Fluorescein-5-isothiocyanate 85-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 1909249-1 1991 An optical sensor for anticholinesterases (AntiChEs) was constructed by immobilizing fluorescein isothiocyanate (FITC)-tagged eel electric organ acetylcholinesterase (AChE) on quartz fibers and monitoring enzyme activity. Fluorescein-5-isothiocyanate 85-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 1909249-1 1991 An optical sensor for anticholinesterases (AntiChEs) was constructed by immobilizing fluorescein isothiocyanate (FITC)-tagged eel electric organ acetylcholinesterase (AChE) on quartz fibers and monitoring enzyme activity. Fluorescein-5-isothiocyanate 113-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 1909249-1 1991 An optical sensor for anticholinesterases (AntiChEs) was constructed by immobilizing fluorescein isothiocyanate (FITC)-tagged eel electric organ acetylcholinesterase (AChE) on quartz fibers and monitoring enzyme activity. Fluorescein-5-isothiocyanate 113-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 1909249-2 1991 The pH-dependent fluorescent signal generated by FITC-AChE, present in the evanescent zone on the fiber surface, was quenched by the protons produced during acetylcholine (ACh) hydrolysis. Fluorescein-5-isothiocyanate 49-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 1909249-2 1991 The pH-dependent fluorescent signal generated by FITC-AChE, present in the evanescent zone on the fiber surface, was quenched by the protons produced during acetylcholine (ACh) hydrolysis. Acetylcholine 157-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 1909249-4 1991 The reversible inhibitor edrophonium (0.1 mM) inhibited AChE and consequently reduced fluorescence quenching. Edrophonium 25-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 1909249-8 1991 However, the DFP-treated AChE biosensor recovered fully after a 10-min perfusion with pralidoxime (2-PAM). pralidoxime 86-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 1926583-2 1991 Such reversible inhibitors as tacrine (of non-competition action), ambenonium (mixed action) and galanthamine (competitive type of action) decelerate the decarbamylation rate of acetylcholinesterase. Tacrine 30-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-198 1926583-2 1991 Such reversible inhibitors as tacrine (of non-competition action), ambenonium (mixed action) and galanthamine (competitive type of action) decelerate the decarbamylation rate of acetylcholinesterase. Ambenonium Chloride 67-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-198 1926583-2 1991 Such reversible inhibitors as tacrine (of non-competition action), ambenonium (mixed action) and galanthamine (competitive type of action) decelerate the decarbamylation rate of acetylcholinesterase. Galantamine 97-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-198 1926583-3 1991 At pH 6 tacrine inhibits the reduction rate of soluble acetylcholinesterase activity of human erythrocytes more intensively than that of membrane-bound acetylcholinesterase. Tacrine 8-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 2029540-0 1991 Alkylation of acetylcholinesterase anionic centre with aziridinium ion accelerates the enzyme acylation step. aziridinium 55-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 2029540-1 1991 Affinity labelling of acetylcholinesterase (EC 3.1.1.7, acetylcholine acetylhydrolase) anionic centre with N,N-dimethyl-2-phenylaziridinium ion accelerates the hydrolysis of non-ionic acetic esters by increasing the rate of the enzyme acylation step at least 500-times while the rate of the deacylation step remains unchanged. N,N-dimethyl-2-phenylaziridinium 107-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 2029540-1 1991 Affinity labelling of acetylcholinesterase (EC 3.1.1.7, acetylcholine acetylhydrolase) anionic centre with N,N-dimethyl-2-phenylaziridinium ion accelerates the hydrolysis of non-ionic acetic esters by increasing the rate of the enzyme acylation step at least 500-times while the rate of the deacylation step remains unchanged. ethyl acetate 184-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 1895153-3 1991 Since pyridostigmine reversible blocks acetylcholinesterase (AChE) at the neuromuscular junction, we studied the correlation between the enzyme"s blood activity (erythrocyte-bound AChE) and PPC, on the one hand, and between blood AChE activity and the clinical status of the individual patient, on the other. Pyridostigmine Bromide 6-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 1895153-3 1991 Since pyridostigmine reversible blocks acetylcholinesterase (AChE) at the neuromuscular junction, we studied the correlation between the enzyme"s blood activity (erythrocyte-bound AChE) and PPC, on the one hand, and between blood AChE activity and the clinical status of the individual patient, on the other. Pyridostigmine Bromide 6-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 1651150-2 1991 Colchicine lesions resulted in a loss of acetylcholinesterase staining in the cortex which recovered to control levels by 14 months. Colchicine 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 1645684-2 1991 Intravenous famotidine (20 mg), at a dose level in which an inhibitory effect on acetylcholinesterase activity is not recognized, was given to 13 patients with progressive systemic sclerosis but no other disorders. Famotidine 12-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 1645684-6 1991 It was, therefore, concluded that intravenous administration of famotidine affected upper gastrointestinal motility, especially the lower esophageal sphincter pressure, through an as yet unknown mechanism other than inhibition of acetylcholinesterase activity, gastric alkalinization, or elevation of serum gastrin levels. Famotidine 64-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 230-250 2061549-8 1991 When AChE was inhibited 39% with 37 nM VX, the addition of proscillaridin increased the inhibition to 51% (a 1.3-fold increase). Proscillaridin 59-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 2061549-9 1991 When TMB-4 was added to the proscillaridin- and VX-inhibited AChE mixture, the inhibition decreased from 50% to 32% (a 0.37-fold decrease), whereas TMB-4 alone added to VX-inhibited AChE decreased the inhibition from 39% to 24% (a 0.38-fold decrease). Trimedoxime 5-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 2061549-9 1991 When TMB-4 was added to the proscillaridin- and VX-inhibited AChE mixture, the inhibition decreased from 50% to 32% (a 0.37-fold decrease), whereas TMB-4 alone added to VX-inhibited AChE decreased the inhibition from 39% to 24% (a 0.38-fold decrease). Trimedoxime 5-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-186 2061549-9 1991 When TMB-4 was added to the proscillaridin- and VX-inhibited AChE mixture, the inhibition decreased from 50% to 32% (a 0.37-fold decrease), whereas TMB-4 alone added to VX-inhibited AChE decreased the inhibition from 39% to 24% (a 0.38-fold decrease). Proscillaridin 28-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 2061549-9 1991 When TMB-4 was added to the proscillaridin- and VX-inhibited AChE mixture, the inhibition decreased from 50% to 32% (a 0.37-fold decrease), whereas TMB-4 alone added to VX-inhibited AChE decreased the inhibition from 39% to 24% (a 0.38-fold decrease). Proscillaridin 28-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-186 2061549-9 1991 When TMB-4 was added to the proscillaridin- and VX-inhibited AChE mixture, the inhibition decreased from 50% to 32% (a 0.37-fold decrease), whereas TMB-4 alone added to VX-inhibited AChE decreased the inhibition from 39% to 24% (a 0.38-fold decrease). VX 48-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 2061549-9 1991 When TMB-4 was added to the proscillaridin- and VX-inhibited AChE mixture, the inhibition decreased from 50% to 32% (a 0.37-fold decrease), whereas TMB-4 alone added to VX-inhibited AChE decreased the inhibition from 39% to 24% (a 0.38-fold decrease). VX 48-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-186 2061549-10 1991 The results show that TMB-4 increases the inhibition of AChE by proscillaridin. Trimedoxime 22-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 2061549-10 1991 The results show that TMB-4 increases the inhibition of AChE by proscillaridin. Proscillaridin 64-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 2061549-11 1991 However, TMB-4 decreases the inhibition of AChE by VX and proscillaridin combined. Trimedoxime 9-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 2016711-6 1991 Significantly, the antidotal effectiveness of the compounds was not dependent on the inhibiting agent nor was there any correlation between in vivo efficacy and in vitro reactivation of ethyl (4-nitrophenyl)methylphosphonate inhibited human acetylcholinesterase. ethyl 4-nitrophenyl methylphosphonate 186-224 acetylcholinesterase (Cartwright blood group) Homo sapiens 241-261 1676644-0 1991 Correlation between plasma physostigmine concentrations and percentage of acetylcholinesterase inhibition over time after controlled release of physostigmine in volunteer subjects. Physostigmine 27-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 2003276-0 1991 Inhibition of acetylcholinesterase by caffeine, anabasine, methyl pyrrolidine and their derivatives. Caffeine 38-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 2003276-0 1991 Inhibition of acetylcholinesterase by caffeine, anabasine, methyl pyrrolidine and their derivatives. Anabasine 48-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 2003276-0 1991 Inhibition of acetylcholinesterase by caffeine, anabasine, methyl pyrrolidine and their derivatives. N-methylpyrrolidine 59-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 2003276-1 1991 The inhibition of acetylcholinesterase (AChE) by caffeine, anabasine, methylpyrrolidine and several derivatives was examined. Caffeine 49-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 2003276-1 1991 The inhibition of acetylcholinesterase (AChE) by caffeine, anabasine, methylpyrrolidine and several derivatives was examined. Caffeine 49-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 2003276-1 1991 The inhibition of acetylcholinesterase (AChE) by caffeine, anabasine, methylpyrrolidine and several derivatives was examined. Anabasine 59-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 2003276-1 1991 The inhibition of acetylcholinesterase (AChE) by caffeine, anabasine, methylpyrrolidine and several derivatives was examined. Anabasine 59-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 2003276-1 1991 The inhibition of acetylcholinesterase (AChE) by caffeine, anabasine, methylpyrrolidine and several derivatives was examined. N-methylpyrrolidine 70-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 2003276-1 1991 The inhibition of acetylcholinesterase (AChE) by caffeine, anabasine, methylpyrrolidine and several derivatives was examined. N-methylpyrrolidine 70-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 2003276-4 1991 A structural feature common to these compounds is the N-methyl determinant of the pyrrolidine ring which may be important in binding to the AChE. Nitrogen 54-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 2003276-4 1991 A structural feature common to these compounds is the N-methyl determinant of the pyrrolidine ring which may be important in binding to the AChE. pyrrolidine 82-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 1849451-5 1991 The recombinant gene product exhibits biochemical traits similar to native "true" acetylcholinesterase as manifested by characteristic substrate inhibition, a Km of 117 microM toward acetylthiocholine, and a high sensitivity to the specific acetylcholinesterase inhibitor BW284C51. Acetylthiocholine 183-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 1849451-5 1991 The recombinant gene product exhibits biochemical traits similar to native "true" acetylcholinesterase as manifested by characteristic substrate inhibition, a Km of 117 microM toward acetylthiocholine, and a high sensitivity to the specific acetylcholinesterase inhibitor BW284C51. Acetylthiocholine 183-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 241-261 1849451-5 1991 The recombinant gene product exhibits biochemical traits similar to native "true" acetylcholinesterase as manifested by characteristic substrate inhibition, a Km of 117 microM toward acetylthiocholine, and a high sensitivity to the specific acetylcholinesterase inhibitor BW284C51. Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide 272-280 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 1849451-5 1991 The recombinant gene product exhibits biochemical traits similar to native "true" acetylcholinesterase as manifested by characteristic substrate inhibition, a Km of 117 microM toward acetylthiocholine, and a high sensitivity to the specific acetylcholinesterase inhibitor BW284C51. Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide 272-280 acetylcholinesterase (Cartwright blood group) Homo sapiens 241-261 1849455-15 1991 Pretreatment with alkaline hydroxylamine is required to render the amphiphilic AChE from human erythrocytes susceptible to digestion by Bacillus thuringiensis phosphatidylinositol-specific phospholipase C (PI-PLC) (Toutant et al., Eur. alkaline hydroxylamine 18-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 1849455-20 1991 In two sublines of K562 cells (48 and 243), we observed that AChE either was directly susceptible to PI-PLC (243) or required a prior deacylation by alkaline hydroxylamine (48). alkaline hydroxylamine 149-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 1849455-21 1991 This suggests that glycolipid anchors in AChE of K562-48 cells, but not those in AChE of K562-243 cells, contain the additional acylation demonstrated in AChE from human erythrocytes. Glycolipids 19-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 2013059-4 1991 Furthermore, within the substantia nigra, a soluble form of acetylcholinesterase is released from the dendrites of dopamine-containing nigrostriatal neurons, independent of cholinergic transmission. Dopamine 115-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 2055358-4 1991 The inhibitory potencies of THP and Pyr were compared by determining their IC50 values for in vitro inhibition of both AChE (brain, erythrocyte) and pseudo-cholinesterase (plasma) in three mammalian species (guinea pig, rat, rabbit). thp 28-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 2055358-4 1991 The inhibitory potencies of THP and Pyr were compared by determining their IC50 values for in vitro inhibition of both AChE (brain, erythrocyte) and pseudo-cholinesterase (plasma) in three mammalian species (guinea pig, rat, rabbit). Pyridostigmine Bromide 36-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 2050843-4 1991 Almost all Betz cells in the motor cortex and up to 80% of layer 3 pyramidal neurons in some parts of the association neocortex yield an AChE-rich staining pattern. betz 11-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 1676644-3 1991 Plasma physostigmine concentrations correlated with percentage of AChE inhibition across time by dose and across all doses and subjects tested. Physostigmine 7-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 1676644-4 1991 These data should be helpful to physicians in adjusting physostigmine dosing, enabling them to use the relatively simple and widely available AChE assay to approximate plasma physostigmine concentrations. Physostigmine 56-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 1676644-4 1991 These data should be helpful to physicians in adjusting physostigmine dosing, enabling them to use the relatively simple and widely available AChE assay to approximate plasma physostigmine concentrations. Physostigmine 175-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 1986786-1 1991 p-Butyroxybenzenediazonium fluoroborate 1 was shown to be a substrate of both acetylcholinesterase (AcChE) and butyrylcholinesterase (BuChE) with Michaelis constants of 6.10(-5) M and 1.3. 4-butyroxybenzenediazonium fluoroborate 0-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 1986786-1 1991 p-Butyroxybenzenediazonium fluoroborate 1 was shown to be a substrate of both acetylcholinesterase (AcChE) and butyrylcholinesterase (BuChE) with Michaelis constants of 6.10(-5) M and 1.3. 4-butyroxybenzenediazonium fluoroborate 0-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-105 1986786-0 1991 p-Butyroxybenzenediazonium fluoroborate, substrate of acetylcholinesterase and butyrylcholinesterase, discriminates between the two enzymes by a specific affinity labelling. 4-butyroxybenzenediazonium fluoroborate 0-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 1986786-4 1991 Kinetic analysis of the inactivation of AcChE (i) by various concentrations of 1 indicated that it behaves as an affinity label, (ii) at three different pH levels suggested that the pKa of the labelled residue was higher than 7 and (iii) in the presence of different selective ligands for either the active site (edrophonium) or the peripheral site (propidium) indicated that 1 alkylated the active site rather than the peripheral one. Edrophonium 313-324 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-45 1986786-4 1991 Kinetic analysis of the inactivation of AcChE (i) by various concentrations of 1 indicated that it behaves as an affinity label, (ii) at three different pH levels suggested that the pKa of the labelled residue was higher than 7 and (iii) in the presence of different selective ligands for either the active site (edrophonium) or the peripheral site (propidium) indicated that 1 alkylated the active site rather than the peripheral one. Propidium 350-359 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-45 1776750-0 1991 Pharmacologic and clinicopharmacologic properties of SDZ ENA 713, a centrally selective acetylcholinesterase inhibitor. Sulfadiazine 53-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 1759562-5 1991 We have found that the number of AChE-, thioflavine S- and Tau-positive SP that accumulate in the dentate gyrus is positively correlated with the density of thioflavine S-stained neurofibrillary tangles in layers II and III of the entorhinal cortex. thioflavin T 157-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 1825561-0 1991 Measurement of leukotrienes by enzyme immunoassays using acetylcholinesterase as label. Leukotrienes 15-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 1776750-0 1991 Pharmacologic and clinicopharmacologic properties of SDZ ENA 713, a centrally selective acetylcholinesterase inhibitor. Rivastigmine 57-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 1781739-3 1991 The rate constants of inhibition (ka) and reactivation (k + 3) of human and hen brain AChE and NTE by methamidophos resolved optical isomers are here reported. methamidophos 102-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 1781739-7 1991 D-(+) methamidophos 10(-3).ka (M-1.m-1) for human and hen AChE was 0.24 and 0.13; 10(3).k+3 (m-1) was 0.83 and 0.69, respectively. d-(+) methamidophos 0-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 1781739-8 1991 L-(-) Methamidophos 10(-3).ka (M-1.m-1) for human and hen AChE was 5.7 and 2.8, whereas 10(3).k+3 (m-1) was 6.50 and 1.52, respectively. l-(-) methamidophos 0-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 1781739-9 1991 L-(-)-Inhibited AChE reactivated to about 60% for human and 30% for hen enzymes, respectively. l-(-) 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 1781739-12 1991 The larger and faster reactivation of human AChE inhibited in vitro by L-(-) methamidophos suggests that a corresponding effect might be possible in vivo and therefore explain, in part, the relatively higher susceptibility of man to delayed polyneuropathy induced by racemic methamidophos which occurs, however, with doses always causing severe cholinergic toxicity. l-(-) methamidophos 71-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 1781739-12 1991 The larger and faster reactivation of human AChE inhibited in vitro by L-(-) methamidophos suggests that a corresponding effect might be possible in vivo and therefore explain, in part, the relatively higher susceptibility of man to delayed polyneuropathy induced by racemic methamidophos which occurs, however, with doses always causing severe cholinergic toxicity. methamidophos 77-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 1646743-14 1991 This means that a G2 AChE dimer with a glycolipid anchoring domain is present in the human heart. Glycolipids 39-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 1793553-2 1991 The mechanism is based on the detection of H2O2 which is a product of the sequential enzyme reactions of acetylcholinesterase and choline oxidase. Hydrogen Peroxide 43-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 1825627-11 1991 If the effects of the nondepolarizing neuromuscular blocking agents must be reversed more rapidly, acetylcholinesterase-inhibiting agents such as physostigmine, neostigmine, pyridostigmine, and edrophonium can be used. Physostigmine 146-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 1825627-11 1991 If the effects of the nondepolarizing neuromuscular blocking agents must be reversed more rapidly, acetylcholinesterase-inhibiting agents such as physostigmine, neostigmine, pyridostigmine, and edrophonium can be used. Pyridostigmine Bromide 174-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 12106448-0 1991 Regeneration of Lesioned Septohippocampal Acetylcholinesterase-positive Axons is Improved by Antibodies Against the Myelin-associated Neurite Growth Inhibitors NI-35/250. ni-35 160-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 1806475-2 1991 The aim of our study was to investigate the underlying mechanism of this diminished GH response in these patients using pyridostigmine (PD), an acetylcholinesterase inhibitor, which is reported to increase GH secretion by reducing somatostatin tone. Pyridostigmine Bromide 120-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-164 1669449-1 1991 Six N-alkyl and N-aryl 5-(1,3,3-trimethylindolinyl) carbamates were synthesized and studied for their structure-activity relationships in inhibiting eel acetylcholinesterase (AChE). n-alkyl and n-aryl 5-(1,3,3-trimethylindolinyl) carbamates 4-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-173 1669449-1 1991 Six N-alkyl and N-aryl 5-(1,3,3-trimethylindolinyl) carbamates were synthesized and studied for their structure-activity relationships in inhibiting eel acetylcholinesterase (AChE). n-alkyl and n-aryl 5-(1,3,3-trimethylindolinyl) carbamates 4-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 175-179 2005669-1 1991 Although acetylcholinesterase is the target molecule of organophosphate poisoning, it is not always assayed in clinical evaluations which include only the determination of plasma or serum cholinesterase. Organophosphates 56-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 2037866-5 1991 Examples of acetylcholinesterase inhibition by two diagonally different phosphonate inhibitors are used for illustrating accuracy and precision of the competitive irreversible inhibition technique at different levels of enzyme saturation with inhibitor and substrate. Organophosphonates 72-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 2005669-9 1991 The determination of both cholinesterase and acetylcholinesterase assists the evaluation of individuals exposed to or poisoned by organophosphate, the differentiation of other conditions affecting cholinesterase and the recognition of genetically atypical cholinesterase. Organophosphates 130-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 1710763-2 1991 DBL induced prolonged inhibition of AChE and NTE when administered either early or late in incubation, structural malformations if administered before organogenesis, posthatching paresis if administered after organogenesis, and delayed deficits of gait if administered after hatching. desbromoleptophos 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 2271673-1 1990 This paper examines covalent reactivity of AchE with respect to cationic and uncharged methylphosphonates and substrates in the absence and presence of cationic ligands selective for the active center and the peripheral anionic site. methylphosphonic acid 87-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 2176500-7 1990 The high protective effect of SAD-128 against AChE inhibition was confirmed by the EPR method regardless of the organophosphorus inhibitor tested. SAD-128 30-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 2263619-5 1990 When ligated to the cDNA and constructed into a transcription vector, this sequence encoded a synthetic mRNA translated in microinjected oocytes into catalytically active AcChoEase with marked preference for acetylthiocholine over butyrylthiocholine as a substrate, susceptibility to inhibition by the AcChoEase inhibitor BW284C51, and resistance to the BtChoEase inhibitor tetraisopropylpyrophosphoramide. Acetylthiocholine 208-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-180 2263619-5 1990 When ligated to the cDNA and constructed into a transcription vector, this sequence encoded a synthetic mRNA translated in microinjected oocytes into catalytically active AcChoEase with marked preference for acetylthiocholine over butyrylthiocholine as a substrate, susceptibility to inhibition by the AcChoEase inhibitor BW284C51, and resistance to the BtChoEase inhibitor tetraisopropylpyrophosphoramide. Acetylthiocholine 208-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 302-311 2263619-5 1990 When ligated to the cDNA and constructed into a transcription vector, this sequence encoded a synthetic mRNA translated in microinjected oocytes into catalytically active AcChoEase with marked preference for acetylthiocholine over butyrylthiocholine as a substrate, susceptibility to inhibition by the AcChoEase inhibitor BW284C51, and resistance to the BtChoEase inhibitor tetraisopropylpyrophosphoramide. Butyrylthiocholine 231-249 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-180 2263619-5 1990 When ligated to the cDNA and constructed into a transcription vector, this sequence encoded a synthetic mRNA translated in microinjected oocytes into catalytically active AcChoEase with marked preference for acetylthiocholine over butyrylthiocholine as a substrate, susceptibility to inhibition by the AcChoEase inhibitor BW284C51, and resistance to the BtChoEase inhibitor tetraisopropylpyrophosphoramide. Butyrylthiocholine 231-249 acetylcholinesterase (Cartwright blood group) Homo sapiens 302-311 2263619-5 1990 When ligated to the cDNA and constructed into a transcription vector, this sequence encoded a synthetic mRNA translated in microinjected oocytes into catalytically active AcChoEase with marked preference for acetylthiocholine over butyrylthiocholine as a substrate, susceptibility to inhibition by the AcChoEase inhibitor BW284C51, and resistance to the BtChoEase inhibitor tetraisopropylpyrophosphoramide. Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide 322-330 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-180 2263619-5 1990 When ligated to the cDNA and constructed into a transcription vector, this sequence encoded a synthetic mRNA translated in microinjected oocytes into catalytically active AcChoEase with marked preference for acetylthiocholine over butyrylthiocholine as a substrate, susceptibility to inhibition by the AcChoEase inhibitor BW284C51, and resistance to the BtChoEase inhibitor tetraisopropylpyrophosphoramide. Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide 322-330 acetylcholinesterase (Cartwright blood group) Homo sapiens 302-311 2263619-5 1990 When ligated to the cDNA and constructed into a transcription vector, this sequence encoded a synthetic mRNA translated in microinjected oocytes into catalytically active AcChoEase with marked preference for acetylthiocholine over butyrylthiocholine as a substrate, susceptibility to inhibition by the AcChoEase inhibitor BW284C51, and resistance to the BtChoEase inhibitor tetraisopropylpyrophosphoramide. Tetraisopropylpyrophosphamide 374-405 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-180 2263619-5 1990 When ligated to the cDNA and constructed into a transcription vector, this sequence encoded a synthetic mRNA translated in microinjected oocytes into catalytically active AcChoEase with marked preference for acetylthiocholine over butyrylthiocholine as a substrate, susceptibility to inhibition by the AcChoEase inhibitor BW284C51, and resistance to the BtChoEase inhibitor tetraisopropylpyrophosphoramide. Tetraisopropylpyrophosphamide 374-405 acetylcholinesterase (Cartwright blood group) Homo sapiens 302-311 2146267-1 1990 We analyzed the molecular species composition of the glycosylphosphatidylinositol (GPI) anchor of Torpedo marmorata acetylcholinesterase (AChE) and compared it to that of the membrane phosphatidylinositol (PI) as well as the other major phospholipid classes of T. marmorata electrocytes. Glycosylphosphatidylinositols 53-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 2146267-1 1990 We analyzed the molecular species composition of the glycosylphosphatidylinositol (GPI) anchor of Torpedo marmorata acetylcholinesterase (AChE) and compared it to that of the membrane phosphatidylinositol (PI) as well as the other major phospholipid classes of T. marmorata electrocytes. Glycosylphosphatidylinositols 83-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 2146267-1 1990 We analyzed the molecular species composition of the glycosylphosphatidylinositol (GPI) anchor of Torpedo marmorata acetylcholinesterase (AChE) and compared it to that of the membrane phosphatidylinositol (PI) as well as the other major phospholipid classes of T. marmorata electrocytes. Phosphatidylinositols 61-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 2146267-1 1990 We analyzed the molecular species composition of the glycosylphosphatidylinositol (GPI) anchor of Torpedo marmorata acetylcholinesterase (AChE) and compared it to that of the membrane phosphatidylinositol (PI) as well as the other major phospholipid classes of T. marmorata electrocytes. Phospholipids 237-249 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 2146267-2 1990 Purified amphiphilic AChE was treated with PI-specific phospholipase C in order to release the diradylglycerol moiety from the membrane anchoring domain. diarachidonyl diglyceride 95-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 2146267-5 1990 The PI moiety of the GPI anchor of AChE consisted exclusively of diacyl molecular species. Glycosylphosphatidylinositols 21-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 2146267-10 1990 263, 18766-18775), our results on AChE from Torpedo demonstrate that the composition of the PI moiety of the GPI anchor of a protein is not characteristic for that protein but may vary between species. Glycosylphosphatidylinositols 109-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 2173910-4 1990 Acetylcholinesterase was found to be enriched 2-3-fold in microvesicles, possibly because the removal of non-diffusing proteins from the vesiculating region of the lipid bilayer allows more space for freely diffusing proteins like acetylcholinesterase to enter the microvesicle membrane. Lipid Bilayers 164-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 2253299-0 1990 In vitro effects of fluoride and bromide on pseudocholinesterase and acetylcholinesterase activities. Fluorides 20-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 2253299-0 1990 In vitro effects of fluoride and bromide on pseudocholinesterase and acetylcholinesterase activities. Bromides 33-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 2253299-1 1990 The in vitro effects of two metabolites of inhalational anaesthetics, fluoride and bromide, on pseudocholinesterase (PCHE) and acetylcholinesterase (ACHE) activities in the blood samples of seven healthy patients were studied. Fluorides 70-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 2253299-3 1990 Fluoride at the levels achieved with clinical concentrations of enflurane and sevoflurane (25-75 microM.L-1) inhibited PCHE activity by 28-65 per cent (P less than 0.01) and ACHE activity by less than five per cent (P greater than 0.05). Fluorides 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 2253299-3 1990 Fluoride at the levels achieved with clinical concentrations of enflurane and sevoflurane (25-75 microM.L-1) inhibited PCHE activity by 28-65 per cent (P less than 0.01) and ACHE activity by less than five per cent (P greater than 0.05). Sevoflurane 78-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 2256118-25 1990 The approach holds promise for predictive simulation of organophosphate-mediated AChE inhibition in humans. Organophosphates 56-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 2096824-1 1990 A series of O,O-diethyl-1-(N-alpha-hydrohexafluoroisobutyryl)aminoalkylphos phonates (APh) has been synthesized and their interaction with human erythrocyte acetylcholinesterase (AChE) and with horse serum butyrylcholinesterase (BuChE) studied. o,o-diethyl-1-(n-alpha-hydrohexafluoroisobutyryl)aminoalkylphos phonates 12-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-177 2096824-1 1990 A series of O,O-diethyl-1-(N-alpha-hydrohexafluoroisobutyryl)aminoalkylphos phonates (APh) has been synthesized and their interaction with human erythrocyte acetylcholinesterase (AChE) and with horse serum butyrylcholinesterase (BuChE) studied. o,o-diethyl-1-(n-alpha-hydrohexafluoroisobutyryl)aminoalkylphos phonates 12-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 179-183 2290622-2 1990 Butyrylcholine was much more effective than acetylcholine in reducing the histochemical reaction for acetylcholinesterase not only in neuronal fibers, but also in plaques and tangles. butyrylcholine 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 2290622-2 1990 Butyrylcholine was much more effective than acetylcholine in reducing the histochemical reaction for acetylcholinesterase not only in neuronal fibers, but also in plaques and tangles. Acetylcholine 44-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 2241237-10 1990 One subject who had urinary acephate excretion between 3 and 8 mg/L, showed slightly decreased values of PChE during exposure and of AChE after exposure. acephate 28-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 1964378-1 1990 A number of sulphydryl reagents inhibit AChE of Torpedo california with pseudo-first-order kinetics, and inhibition can be retarded by quaternary ligands which bind at either the catalytic or peripheral anionic binding sites. sulphydryl reagents 12-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 2253329-2 1990 Acetylcholinesterase histochemistry was used to identify cholinergic cells after pretreatment with diisopropylfluorophosphate. Isoflurophate 99-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 2147598-3 1990 Pyridostigmine (PD), an acetylcholinesterase inhibitor, is hypothesized to enhance the GH response to GHRH in normal subjects probably via a decrease in the somatostatinergic tone. Pyridostigmine Bromide 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 2147598-3 1990 Pyridostigmine (PD), an acetylcholinesterase inhibitor, is hypothesized to enhance the GH response to GHRH in normal subjects probably via a decrease in the somatostatinergic tone. Pyridostigmine Bromide 16-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 2147598-3 1990 Pyridostigmine (PD), an acetylcholinesterase inhibitor, is hypothesized to enhance the GH response to GHRH in normal subjects probably via a decrease in the somatostatinergic tone. ghrh 102-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 2223340-3 1990 A laboratory study was therefore conducted on the inhibition of human plasma cholinesterase (PCHE) and erythrocyte acetylcholinesterase (ACHE) activity by varying concentrations of metoclopramide using acetylthiocholine as substrate. Metoclopramide 181-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 2223340-3 1990 A laboratory study was therefore conducted on the inhibition of human plasma cholinesterase (PCHE) and erythrocyte acetylcholinesterase (ACHE) activity by varying concentrations of metoclopramide using acetylthiocholine as substrate. Metoclopramide 181-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 2223340-5 1990 ACHE was less sensitive to inhibition by metoclopramide (I50 2.24 x 10(-5) mol litre-1). Metoclopramide 41-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 2223340-6 1990 Analysis of enzyme kinetics at varying substrate concentrations revealed that metoclopramide produced a potent non-competitive, dose-dependent inhibition of both ACHE and PCHE. Metoclopramide 78-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-166 2400840-0 1990 In vitro inhibition of acetylcholinesterase from four marine species by organophosphates and carbamates. Organophosphates 72-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 2400840-0 1990 In vitro inhibition of acetylcholinesterase from four marine species by organophosphates and carbamates. Carbamates 93-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 2146369-1 1990 The caudate nucleus has the highest acetylcholinesterase (AChE) activity in the brain and it has been shown that autopsied brain tissue of patients with Huntington"s disease (HD) have reduced levels of acetylcholine. Acetylcholine 36-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 2146369-2 1990 Because of these findings, the cholinergic function in HD was studied by measuring cerebrospinal fluid (CSF) choline levels and AChE activity during a randomized, double-blind, cross-over, placebo-controlled clinical trial of isoniazid. Choline 31-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 19215369-0 1990 Pyridostigmine, an Acetylcholinesterase Inhibitor, Stimulates Growth Hormone Release, but has no Effect on Basal Thyrotrophin or Adrenocorticotrophin Levels, or the Thyrotrophin Response to Thyrotrophin-Releasing Hormone. Pyridostigmine Bromide 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 19215369-1 1990 Abstract Pyridostigmine, an acetylcholinesterase inhibitor, stimulates growth hormone (GH) release and is thought to act by inhibiting hypothalamic somatostatin release. Pyridostigmine Bromide 9-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 2165068-6 1990 The cDNA encoding hydrophobic acetylcholinesterase directs the synthesis of enzyme with much greater activity, which is expressed on the outer surface of the cell membrane and can be released by phosphatidylinositol-specific phospholipase C. A mutant truncated acetylcholinesterase which lacks either carboxyl-terminal sequence encoded by the alternative exons is secreted into the medium. Phosphatidylinositols 195-215 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 2165068-6 1990 The cDNA encoding hydrophobic acetylcholinesterase directs the synthesis of enzyme with much greater activity, which is expressed on the outer surface of the cell membrane and can be released by phosphatidylinositol-specific phospholipase C. A mutant truncated acetylcholinesterase which lacks either carboxyl-terminal sequence encoded by the alternative exons is secreted into the medium. Phosphatidylinositols 195-215 acetylcholinesterase (Cartwright blood group) Homo sapiens 261-281 2164016-1 1990 The dihydropyridine calcium channel antagonist nifedipine causes marked reductions in the amounts of acetylcholinesterase (AchE) molecular forms in primary tissue cultures of avian pectoral muscle. Nifedipine 47-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 2164016-1 1990 The dihydropyridine calcium channel antagonist nifedipine causes marked reductions in the amounts of acetylcholinesterase (AchE) molecular forms in primary tissue cultures of avian pectoral muscle. Nifedipine 47-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 2164016-4 1990 These reductions are incompatible with accelerated protein degradation, alterations in posttranslational processing and assembly in the Golgi complex, or enhanced loss of enzyme to the medium, but instead indicate that nifedipine causes a reduction in AchE biosynthesis. Nifedipine 219-229 acetylcholinesterase (Cartwright blood group) Homo sapiens 252-256 2162152-4 1990 Acetylcholinesterase, an enzyme having its active site situated on the extracellular side of the membrane, seemed to be unaffected by most of the modulators employed in this study, with the exception of reversible inhibition by benzyl alcohol. Benzyl Alcohol 228-242 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 1972336-6 1990 Freezing in the presence of strong chaotropic anions (perchlorate, iodide and thiocyanate) caused the irreversible inactivation of the mosquito AChE. perchlorate 54-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 1972336-6 1990 Freezing in the presence of strong chaotropic anions (perchlorate, iodide and thiocyanate) caused the irreversible inactivation of the mosquito AChE. Iodides 67-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 1972336-6 1990 Freezing in the presence of strong chaotropic anions (perchlorate, iodide and thiocyanate) caused the irreversible inactivation of the mosquito AChE. thiocyanate 78-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 1972336-10 1990 At this temperature, even weak chaotropic anions (fluoride, chloride and nitrate), while in combination with non-ionic detergents that solubilized mosquito AChE efficiently, reduced the enzyme activity of these fractions. Fluorides 50-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-160 1972336-10 1990 At this temperature, even weak chaotropic anions (fluoride, chloride and nitrate), while in combination with non-ionic detergents that solubilized mosquito AChE efficiently, reduced the enzyme activity of these fractions. Chlorides 60-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-160 1972336-10 1990 At this temperature, even weak chaotropic anions (fluoride, chloride and nitrate), while in combination with non-ionic detergents that solubilized mosquito AChE efficiently, reduced the enzyme activity of these fractions. Nitrates 73-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-160 1972336-14 1990 Thus, antichaotropic anions, such as sulfate, should improve the stability of the mosquito acetylcholinesterase during extraction, purification and storage. Sulfates 37-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 2364948-1 1990 Do chromaffin granules contain a specific secretory acetylcholinesterase? chromaffin 3-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 2364948-2 1990 The presence of acetylcholinesterase (AChE) in chromaffin granules has been controversial for a long time. chromaffin 47-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 2364948-2 1990 The presence of acetylcholinesterase (AChE) in chromaffin granules has been controversial for a long time. chromaffin 47-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 2350325-0 1990 Pyridostigmine-induced inhibition of blood acetylcholinesterase (AChE) and resulting effects on manual ocular tracking performance in the trained baboon. Pyridostigmine Bromide 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 2350325-5 1990 The effect of intramuscular injections of pyridostigmine (0.5 mg/kg) was studied on blood acetylcholinesterase activity in alert baboons. Pyridostigmine Bromide 42-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 2332047-0 1990 The interaction of amiloride with acetylcholinesterase and butyrylcholinesterase. Amiloride 19-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 2332047-1 1990 The diuretic drug amiloride was found to be a powerful inhibitor of the reaction of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with their specific choline ester substrates. Amiloride 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 2184685-0 1990 Acetylcholinesterase inhibitor, pyridostigmine bromide, reduces skin blood flow in humans. Pyridostigmine Bromide 32-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 2184685-2 1990 Pyridostigmine bromide (PYR), an acetylcholinesterase (AChE) inhibitor, was ingested (30 mg) approximately 150 min before one experiment, and no drug was administered during the other experiment (control). Pyridostigmine Bromide 0-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 2184685-2 1990 Pyridostigmine bromide (PYR), an acetylcholinesterase (AChE) inhibitor, was ingested (30 mg) approximately 150 min before one experiment, and no drug was administered during the other experiment (control). Pyridostigmine Bromide 0-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 2184685-2 1990 Pyridostigmine bromide (PYR), an acetylcholinesterase (AChE) inhibitor, was ingested (30 mg) approximately 150 min before one experiment, and no drug was administered during the other experiment (control). Pyridostigmine Bromide 24-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 2362084-0 1990 Oxime-induced reactivation of acetylcholinesterase inhibited by organophosphinates. Oximes 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 2362084-0 1990 Oxime-induced reactivation of acetylcholinesterase inhibited by organophosphinates. organophosphinates 64-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 2362084-1 1990 The comparative potency of oximes for reactivation of inhibited eel acetylcholinesterase (AChE) in vitro is dependent on the organophosphinate inhibitor. Oximes 27-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 2362084-1 1990 The comparative potency of oximes for reactivation of inhibited eel acetylcholinesterase (AChE) in vitro is dependent on the organophosphinate inhibitor. Oximes 27-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 2362084-1 1990 The comparative potency of oximes for reactivation of inhibited eel acetylcholinesterase (AChE) in vitro is dependent on the organophosphinate inhibitor. organophosphinate 125-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 2362084-1 1990 The comparative potency of oximes for reactivation of inhibited eel acetylcholinesterase (AChE) in vitro is dependent on the organophosphinate inhibitor. organophosphinate 125-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 2362084-3 1990 This work was done to identify more clearly the nature of phosphinylated AChE with regard to oxime reactivation potency and the potential of phosphinates as pretreatment drugs to protect AChE against organophosphonate poisoning. Oximes 93-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 2362084-3 1990 This work was done to identify more clearly the nature of phosphinylated AChE with regard to oxime reactivation potency and the potential of phosphinates as pretreatment drugs to protect AChE against organophosphonate poisoning. phosphinates 141-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 2362084-3 1990 This work was done to identify more clearly the nature of phosphinylated AChE with regard to oxime reactivation potency and the potential of phosphinates as pretreatment drugs to protect AChE against organophosphonate poisoning. phosphinates 141-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 2362084-3 1990 This work was done to identify more clearly the nature of phosphinylated AChE with regard to oxime reactivation potency and the potential of phosphinates as pretreatment drugs to protect AChE against organophosphonate poisoning. Organophosphonates 200-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 2362084-3 1990 This work was done to identify more clearly the nature of phosphinylated AChE with regard to oxime reactivation potency and the potential of phosphinates as pretreatment drugs to protect AChE against organophosphonate poisoning. Organophosphonates 200-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 2362084-6 1990 Incubation of the inhibited enzyme (I-AChE) at 25 degrees C was with 0.30 microM oxime for PMP, 3.0 microM oxime for sarin and CPMP and 100 microM oxime for the two remaining phosphinates. Oximes 81-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 2362084-6 1990 Incubation of the inhibited enzyme (I-AChE) at 25 degrees C was with 0.30 microM oxime for PMP, 3.0 microM oxime for sarin and CPMP and 100 microM oxime for the two remaining phosphinates. pmp 91-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 2362084-6 1990 Incubation of the inhibited enzyme (I-AChE) at 25 degrees C was with 0.30 microM oxime for PMP, 3.0 microM oxime for sarin and CPMP and 100 microM oxime for the two remaining phosphinates. Oximes 107-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 2362084-6 1990 Incubation of the inhibited enzyme (I-AChE) at 25 degrees C was with 0.30 microM oxime for PMP, 3.0 microM oxime for sarin and CPMP and 100 microM oxime for the two remaining phosphinates. nulibry 127-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 2362084-6 1990 Incubation of the inhibited enzyme (I-AChE) at 25 degrees C was with 0.30 microM oxime for PMP, 3.0 microM oxime for sarin and CPMP and 100 microM oxime for the two remaining phosphinates. Oximes 107-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 2362084-6 1990 Incubation of the inhibited enzyme (I-AChE) at 25 degrees C was with 0.30 microM oxime for PMP, 3.0 microM oxime for sarin and CPMP and 100 microM oxime for the two remaining phosphinates. phosphinates 175-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 2362084-7 1990 AChE activity was assayed spectrophotometrically for 3.0 min at 272.5 nm at 25 degrees C in 0.10 M MOPS buffer (pH 7.60) using phenyl acetate as substrate. morpholinopropane sulfonic acid 99-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 2362084-7 1990 AChE activity was assayed spectrophotometrically for 3.0 min at 272.5 nm at 25 degrees C in 0.10 M MOPS buffer (pH 7.60) using phenyl acetate as substrate. phenyl acetate 127-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 2161932-7 1990 The perikaryal markers, CNPase and AChE activity were most enriched in membrane fractions found at a sucrose concentration of 23% and 21%, respectively. Sucrose 101-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 1692236-1 1990 Monoclonal antibody 25B1 generated against diisopropyl phosphorofluoridate inhibited fetal bovine serum acetylcholinesterase has been extensively characterized with respect to its anticholinesterase properties. Isoflurophate 43-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 1692236-3 1990 Monoclonal antibody 25B1 appears to be directed against a conformational epitope located in close proximity to the catalytic center of the enzyme and was found to be most suitable for studying the stabilization of the active site of acetylcholinesterase against denaturation by heat or guanidine following phosphorylation by organophosphorus anticholinesterase compounds. Guanidine 286-295 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-253 1692236-5 1990 Among all the organophosphates tested, the combination of a methyl group and a negatively charged oxygen attached to the P atom, CH3P(O)(O-)-AChE, conferred the greatest protection to the active site of aged or nonaged organophosphoryl conjugates of acetylcholinesterase. Oxygen 98-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 250-270 2109445-2 1990 In normal subjects, the GH response to GHRH is enhanced by the acetylcholinesterase inhibitor, pyridostigmine. Pyridostigmine Bromide 95-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 2194939-4 1990 Solubilization of normal, diabetic and insulin treated diabetic red cell membranes with Triton X-100 (0.2% v/v) caused a general decline in AChE activity, however the per cent decline in activity of diabetic enzyme was lower as compared to normal and insulin treated conditions. Octoxynol 88-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 2180181-2 1990 Organophosphorus and carbamate insecticides produce acute toxicosis via a common mechanism--the inhibition of acetylcholinesterase--and, therefore, these categories of insecticides are considered together. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 2180181-2 1990 Organophosphorus and carbamate insecticides produce acute toxicosis via a common mechanism--the inhibition of acetylcholinesterase--and, therefore, these categories of insecticides are considered together. Carbamates 21-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 2310017-2 1990 Acetylcholine and choline eluting from the LC column are introduced into a reactor containing immobilized acetylcholinesterase, which hydrolyzes acetylcholine to choline. Acetylcholine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 2310017-2 1990 Acetylcholine and choline eluting from the LC column are introduced into a reactor containing immobilized acetylcholinesterase, which hydrolyzes acetylcholine to choline. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 2310017-2 1990 Acetylcholine and choline eluting from the LC column are introduced into a reactor containing immobilized acetylcholinesterase, which hydrolyzes acetylcholine to choline. Choline 18-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 2314926-3 1990 These differences are probably related to the presence of higher levels of acetylcholinesterase in the TBZ-resistant strains than in the susceptible strains. Thiabendazole 103-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 2298208-4 1990 In Triton X-100 extracts of the subline K562-243, phosphatidylinositol-specific phospholipase C (PtdIns-PLC) from Bacillus thuringiensis converted most of the G2a AChE into a hydrophilic dimer (G2h), indicating that the G2a form possessed a hydrophobic glycoinositol phospholipid that mediated its attachment to the membrane. Octoxynol 3-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 2298208-4 1990 In Triton X-100 extracts of the subline K562-243, phosphatidylinositol-specific phospholipase C (PtdIns-PLC) from Bacillus thuringiensis converted most of the G2a AChE into a hydrophilic dimer (G2h), indicating that the G2a form possessed a hydrophobic glycoinositol phospholipid that mediated its attachment to the membrane. Phosphatidylinositols 50-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 2298208-8 1990 In this respect, the amphiphilic dimer of K562-48 AChE resembles the G2a form of human erythrocyte AChE, which is resistant to PtdIns-PLC because of the direct palmitoylation of an inositol hydroxyl group in the anchor [Roberts et al. inositol hydroxyl 181-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 2298208-8 1990 In this respect, the amphiphilic dimer of K562-48 AChE resembles the G2a form of human erythrocyte AChE, which is resistant to PtdIns-PLC because of the direct palmitoylation of an inositol hydroxyl group in the anchor [Roberts et al. inositol hydroxyl 181-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 2332047-1 1990 The diuretic drug amiloride was found to be a powerful inhibitor of the reaction of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with their specific choline ester substrates. Amiloride 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 2332047-1 1990 The diuretic drug amiloride was found to be a powerful inhibitor of the reaction of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with their specific choline ester substrates. choline ester 165-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 2332047-1 1990 The diuretic drug amiloride was found to be a powerful inhibitor of the reaction of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with their specific choline ester substrates. choline ester 165-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 2332047-3 1990 On the other hand, when added to a mixture of cholinesterase (AChE and BChE) and neutral substrates, amiloride, in some cases, enhanced the reaction rate. Amiloride 101-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 2294657-0 1990 Effects of tacrine, aminopyridines, and physostigmine on acetylcholinesterase, acetylcholine release, and potassium currents. Physostigmine 40-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 2095347-2 1990 Epigalanthamine, a diastereomer of GAL, was 130-times less potent in vitro in its effect on acetylcholinesterase (AChE) in erythrocytes than the parent compound, and it did not differ significantly from the ketone galanthaminone. Galantamin 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 2271146-2 1990 New data on the analysis of nicotine, fluoride ion, and some organophosphorus compounds are reported using the present AChE sensor based on the inhibition of the immobilized acetylcholine esterase. Nicotine 28-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 2271146-2 1990 New data on the analysis of nicotine, fluoride ion, and some organophosphorus compounds are reported using the present AChE sensor based on the inhibition of the immobilized acetylcholine esterase. Fluorides 38-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 2271146-2 1990 New data on the analysis of nicotine, fluoride ion, and some organophosphorus compounds are reported using the present AChE sensor based on the inhibition of the immobilized acetylcholine esterase. organophosphorus 61-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 2271146-3 1990 Reactivation of immobilized AChE after inhibition with reversible inhibitor, i.e. nicotine and fluoride ion is carried out using a mixture of working buffer and acetylcholine, whereas reactivation after inhibition with irreversible inhibitor, i.e. organophosphorus compounds is carried out using a mixture of acetylcholine and pyridine-2-aldoxime methiodide (PAM). Nicotine 82-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 2271146-3 1990 Reactivation of immobilized AChE after inhibition with reversible inhibitor, i.e. nicotine and fluoride ion is carried out using a mixture of working buffer and acetylcholine, whereas reactivation after inhibition with irreversible inhibitor, i.e. organophosphorus compounds is carried out using a mixture of acetylcholine and pyridine-2-aldoxime methiodide (PAM). Fluorides 95-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 2271146-3 1990 Reactivation of immobilized AChE after inhibition with reversible inhibitor, i.e. nicotine and fluoride ion is carried out using a mixture of working buffer and acetylcholine, whereas reactivation after inhibition with irreversible inhibitor, i.e. organophosphorus compounds is carried out using a mixture of acetylcholine and pyridine-2-aldoxime methiodide (PAM). Acetylcholine 161-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 2271146-3 1990 Reactivation of immobilized AChE after inhibition with reversible inhibitor, i.e. nicotine and fluoride ion is carried out using a mixture of working buffer and acetylcholine, whereas reactivation after inhibition with irreversible inhibitor, i.e. organophosphorus compounds is carried out using a mixture of acetylcholine and pyridine-2-aldoxime methiodide (PAM). organophosphorus 248-264 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 2271146-3 1990 Reactivation of immobilized AChE after inhibition with reversible inhibitor, i.e. nicotine and fluoride ion is carried out using a mixture of working buffer and acetylcholine, whereas reactivation after inhibition with irreversible inhibitor, i.e. organophosphorus compounds is carried out using a mixture of acetylcholine and pyridine-2-aldoxime methiodide (PAM). Acetylcholine 309-322 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 2271146-3 1990 Reactivation of immobilized AChE after inhibition with reversible inhibitor, i.e. nicotine and fluoride ion is carried out using a mixture of working buffer and acetylcholine, whereas reactivation after inhibition with irreversible inhibitor, i.e. organophosphorus compounds is carried out using a mixture of acetylcholine and pyridine-2-aldoxime methiodide (PAM). pralidoxime 327-357 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 2271146-3 1990 Reactivation of immobilized AChE after inhibition with reversible inhibitor, i.e. nicotine and fluoride ion is carried out using a mixture of working buffer and acetylcholine, whereas reactivation after inhibition with irreversible inhibitor, i.e. organophosphorus compounds is carried out using a mixture of acetylcholine and pyridine-2-aldoxime methiodide (PAM). pralidoxime 359-362 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 2355800-0 1990 Selective inhibition of human acetylcholinesterase by galanthamine in vitro and in vivo. Galantamine 54-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 2079638-0 1990 Acetylcholinesterase inhibition by two phosphoric 4-nitroanilides. 4-nitroanilides 50-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 2355800-5 1990 In vivo, administration of galanthamine in a healthy volunteer and in a patient who underwent long-term treatment confirmed the selectivity of galanthamine for acetylcholinesterase. Galantamine 143-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-180 2326327-4 1990 Intraventricular administration of the acetylcholinesterase inhibitor, physostigmine (10 micrograms bilaterally), activated lordosis of short duration in ovariectomized hamsters primed only with estrogen. Physostigmine 71-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 2215205-3 1990 Organophosphorous chemicals induce inhibition of AChE activity thus leading to nervous system impairment. organophosphorous 0-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 20702200-6 1990 In erythrocyte membranes, n-hexane decreased the activity of AChE more than did carbon disulphide. n-hexane 26-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 20702200-7 1990 In synaptosome membranes, 2-hexanone and 2,5-hexanedione inhibited AChE significantly more than did n-hexane. Methyl n-Butyl Ketone 26-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 20702200-7 1990 In synaptosome membranes, 2-hexanone and 2,5-hexanedione inhibited AChE significantly more than did n-hexane. 2,5-hexanedione 41-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 20702200-11 1990 Thus, in neural synaptosome membranes, the metabolites of n-hexane had a greater effect on AChE activity than did n-hexane. n-hexane 58-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 33588332-5 2021 The sensing mechanism is that OPs-treated acetylcholinesterase (AChE) prevents the formation of thiocholine, thereby minimizing the reduction of MnO2 into Mn2+ and changing the output signal. Thiocholine 96-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 126214-1 1975 Delta1-tetrahydrocannabinol was found to be a potent inhibitor of some membrane-bound enzymes, such as Mg-ATPase, Na-K-ATPase and acetylcholinesterase. Dronabinol 0-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 33588332-5 2021 The sensing mechanism is that OPs-treated acetylcholinesterase (AChE) prevents the formation of thiocholine, thereby minimizing the reduction of MnO2 into Mn2+ and changing the output signal. manganese dioxide 145-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 33588332-5 2021 The sensing mechanism is that OPs-treated acetylcholinesterase (AChE) prevents the formation of thiocholine, thereby minimizing the reduction of MnO2 into Mn2+ and changing the output signal. Manganese(2+) 155-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 33588047-3 2021 We report the QSAR regression model for the estimation of potency of a set of 94 structurally diverse compounds (oximes, N-hydroxyiminoacetamides, 4-aminoquinolines and flavonoids) to inhibit AChE, pKi (AChE). Oximes 113-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 33588047-3 2021 We report the QSAR regression model for the estimation of potency of a set of 94 structurally diverse compounds (oximes, N-hydroxyiminoacetamides, 4-aminoquinolines and flavonoids) to inhibit AChE, pKi (AChE). Oximes 113-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 203-207 33588047-3 2021 We report the QSAR regression model for the estimation of potency of a set of 94 structurally diverse compounds (oximes, N-hydroxyiminoacetamides, 4-aminoquinolines and flavonoids) to inhibit AChE, pKi (AChE). n-hydroxyiminoacetamides 121-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 33588047-3 2021 We report the QSAR regression model for the estimation of potency of a set of 94 structurally diverse compounds (oximes, N-hydroxyiminoacetamides, 4-aminoquinolines and flavonoids) to inhibit AChE, pKi (AChE). n-hydroxyiminoacetamides 121-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 203-207 33588047-3 2021 We report the QSAR regression model for the estimation of potency of a set of 94 structurally diverse compounds (oximes, N-hydroxyiminoacetamides, 4-aminoquinolines and flavonoids) to inhibit AChE, pKi (AChE). 4-aminoquinoline 147-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 33588047-3 2021 We report the QSAR regression model for the estimation of potency of a set of 94 structurally diverse compounds (oximes, N-hydroxyiminoacetamides, 4-aminoquinolines and flavonoids) to inhibit AChE, pKi (AChE). 4-aminoquinoline 147-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 203-207 33588047-3 2021 We report the QSAR regression model for the estimation of potency of a set of 94 structurally diverse compounds (oximes, N-hydroxyiminoacetamides, 4-aminoquinolines and flavonoids) to inhibit AChE, pKi (AChE). Flavonoids 169-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 33588047-3 2021 We report the QSAR regression model for the estimation of potency of a set of 94 structurally diverse compounds (oximes, N-hydroxyiminoacetamides, 4-aminoquinolines and flavonoids) to inhibit AChE, pKi (AChE). Flavonoids 169-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 203-207 33809771-3 2021 Herein, a series of hybrid compounds are reported which were designed and developed by combining an aryl-sulfonamide function with a benzyl-piperidine moiety, the pharmacophore of donepezil (a current anti-AD acetylcholinesterase AChE inhibitor drug) or its benzyl-piperazine analogue. Donepezil 180-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 230-234 33803769-5 2021 Some of these ranitidine analogs also possessed potent inhibitory activities of acetylcholinesterase (AChE), which is another therapeutic target in AD. Ranitidine 14-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 33803769-5 2021 Some of these ranitidine analogs also possessed potent inhibitory activities of acetylcholinesterase (AChE), which is another therapeutic target in AD. Ranitidine 14-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 33803769-6 2021 These ranitidine analogs, by addressing both Abeta aggregation and AChE, offer insight into the key chemical features of a new type of multi-target directed ligands for the pharmaceutical treatment of AD. Ranitidine 6-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 33776997-3 2021 Galantamine, an acetylcholinesterase inhibitor and a cholinergic drug that is clinically-approved (for Alzheimer"s disease) has been implicated in neural cholinergic regulation of inflammation in several conditions characterized with immune and metabolic derangements. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 33234029-5 2022 The enzymes used against ligand and metal complexes respectively: Achethylcholinesterase for ID 4M0E (AChE), butyrylcholinesterase for ID 5NN0 (BChE), alpha-glycosidase for ID 1XSI (alpha-Gly). Metals 36-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 33032200-4 2020 When acetylcholinesterase (AChE) was present, acetylthiocholine (ATCh) was catalytically hydrolyzed into thiocholine, which reduced MnO2 of PTDNP-MnNFs into Mn2+, subsequently blocking the FRET and enhancing the fluorescence. Acetylthiocholine 46-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-25 33032200-4 2020 When acetylcholinesterase (AChE) was present, acetylthiocholine (ATCh) was catalytically hydrolyzed into thiocholine, which reduced MnO2 of PTDNP-MnNFs into Mn2+, subsequently blocking the FRET and enhancing the fluorescence. Acetylthiocholine 46-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 33032200-4 2020 When acetylcholinesterase (AChE) was present, acetylthiocholine (ATCh) was catalytically hydrolyzed into thiocholine, which reduced MnO2 of PTDNP-MnNFs into Mn2+, subsequently blocking the FRET and enhancing the fluorescence. Acetylthiocholine 65-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-25 33032200-4 2020 When acetylcholinesterase (AChE) was present, acetylthiocholine (ATCh) was catalytically hydrolyzed into thiocholine, which reduced MnO2 of PTDNP-MnNFs into Mn2+, subsequently blocking the FRET and enhancing the fluorescence. Acetylthiocholine 65-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 33032200-4 2020 When acetylcholinesterase (AChE) was present, acetylthiocholine (ATCh) was catalytically hydrolyzed into thiocholine, which reduced MnO2 of PTDNP-MnNFs into Mn2+, subsequently blocking the FRET and enhancing the fluorescence. Thiocholine 52-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-25 33032200-4 2020 When acetylcholinesterase (AChE) was present, acetylthiocholine (ATCh) was catalytically hydrolyzed into thiocholine, which reduced MnO2 of PTDNP-MnNFs into Mn2+, subsequently blocking the FRET and enhancing the fluorescence. Thiocholine 52-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 33032200-4 2020 When acetylcholinesterase (AChE) was present, acetylthiocholine (ATCh) was catalytically hydrolyzed into thiocholine, which reduced MnO2 of PTDNP-MnNFs into Mn2+, subsequently blocking the FRET and enhancing the fluorescence. manganese dioxide 132-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-25 33032200-4 2020 When acetylcholinesterase (AChE) was present, acetylthiocholine (ATCh) was catalytically hydrolyzed into thiocholine, which reduced MnO2 of PTDNP-MnNFs into Mn2+, subsequently blocking the FRET and enhancing the fluorescence. manganese dioxide 132-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 33588528-4 2021 Obviously, MnNS display an excellent response to thiocholine, deriving from the catalyzing hydrolysis of acetylthiocholine (ATCh) by acetylcholinesterase (AChE), which switches a homogeneous electrochemical OP detection process based on the depressing AChE activity with a limit of detection (LOD) of 0.025 ng mL-1. Thiocholine 49-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 33588528-4 2021 Obviously, MnNS display an excellent response to thiocholine, deriving from the catalyzing hydrolysis of acetylthiocholine (ATCh) by acetylcholinesterase (AChE), which switches a homogeneous electrochemical OP detection process based on the depressing AChE activity with a limit of detection (LOD) of 0.025 ng mL-1. Thiocholine 49-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 33588528-4 2021 Obviously, MnNS display an excellent response to thiocholine, deriving from the catalyzing hydrolysis of acetylthiocholine (ATCh) by acetylcholinesterase (AChE), which switches a homogeneous electrochemical OP detection process based on the depressing AChE activity with a limit of detection (LOD) of 0.025 ng mL-1. Thiocholine 49-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 252-256 33588528-4 2021 Obviously, MnNS display an excellent response to thiocholine, deriving from the catalyzing hydrolysis of acetylthiocholine (ATCh) by acetylcholinesterase (AChE), which switches a homogeneous electrochemical OP detection process based on the depressing AChE activity with a limit of detection (LOD) of 0.025 ng mL-1. Acetylthiocholine 105-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 33588528-4 2021 Obviously, MnNS display an excellent response to thiocholine, deriving from the catalyzing hydrolysis of acetylthiocholine (ATCh) by acetylcholinesterase (AChE), which switches a homogeneous electrochemical OP detection process based on the depressing AChE activity with a limit of detection (LOD) of 0.025 ng mL-1. Acetylthiocholine 105-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 33588528-4 2021 Obviously, MnNS display an excellent response to thiocholine, deriving from the catalyzing hydrolysis of acetylthiocholine (ATCh) by acetylcholinesterase (AChE), which switches a homogeneous electrochemical OP detection process based on the depressing AChE activity with a limit of detection (LOD) of 0.025 ng mL-1. Acetylthiocholine 105-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 252-256 33032200-4 2020 When acetylcholinesterase (AChE) was present, acetylthiocholine (ATCh) was catalytically hydrolyzed into thiocholine, which reduced MnO2 of PTDNP-MnNFs into Mn2+, subsequently blocking the FRET and enhancing the fluorescence. Manganese(2+) 157-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-25 33032200-4 2020 When acetylcholinesterase (AChE) was present, acetylthiocholine (ATCh) was catalytically hydrolyzed into thiocholine, which reduced MnO2 of PTDNP-MnNFs into Mn2+, subsequently blocking the FRET and enhancing the fluorescence. Manganese(2+) 157-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 25360083-5 2014 We report that ATRA-BDNF induced significant increases in expression of key synaptic genes, brain-specific miRNA and miRNA biogenesis machinery, and in AChE activity, compared with ATRA alone. Tretinoin 15-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 32795450-2 2020 While AChE regulates neurotransmission by hydrolyzing acetylcholine at the postsynaptic membranes and neuromuscular junctions, BChE in plasma has been suggested to be involved in detoxifying toxic compounds. Acetylcholine 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 25539902-0 2015 Imaging acetylcholinesterase density in peripheral organs in Parkinson"s disease with 11C-donepezil PET. Donepezil C-11 86-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-28 25539902-4 2015 The positron emission tomography tracer 5-[(11)C]-methoxy-donepezil was recently validated for imaging acetylcholinesterase density in the brain and peripheral organs. (5-methoxy)donepezil 40-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 18987590-5 2008 In this in vitro study, 7-MEOTA acts as stronger inhibitor of AChE and in this way could be more favorable for treatment of cognitive manifestation of AD. 7-methoxytacrine 24-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 25539902-5 2015 Donepezil is a high-affinity ligand for acetylcholinesterase-the enzyme that catabolizes acetylcholine in cholinergic synapses. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 1711837-6 1991 High AChE inhibition (greater than 90%), however, was measured within hours after dosing because of the higher potency of chlorpyrifos to inhibit this enzyme. Chlorpyrifos 122-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 1711837-7 1991 In vitro studies showed that chlorpyrifos-oxon, the active metabolite of chlorpyrifos, was 10-20 times more active against AChE than against NTE, confirming the clinical observation. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 29-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 1711837-7 1991 In vitro studies showed that chlorpyrifos-oxon, the active metabolite of chlorpyrifos, was 10-20 times more active against AChE than against NTE, confirming the clinical observation. Chlorpyrifos 29-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 1738151-0 1992 QSAR analyses of the substituted indanone and benzylpiperidine rings of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase. indacrinone 33-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 1738151-0 1992 QSAR analyses of the substituted indanone and benzylpiperidine rings of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase. 1-benzylpiperidine 46-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 1738151-0 1992 QSAR analyses of the substituted indanone and benzylpiperidine rings of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase. indanone-benzylpiperidine 84-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 1738151-1 1992 QSAR analyses have been performed on the substituted indanone and benzylpiperidine ring substructures of a set of acetylcholinesterase, AChE, inhibitors of which 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride is a potent in vitro and ex vivo inhibitor. indacrinone 53-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 1738151-1 1992 QSAR analyses have been performed on the substituted indanone and benzylpiperidine ring substructures of a set of acetylcholinesterase, AChE, inhibitors of which 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride is a potent in vitro and ex vivo inhibitor. indacrinone 53-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 1738151-1 1992 QSAR analyses have been performed on the substituted indanone and benzylpiperidine ring substructures of a set of acetylcholinesterase, AChE, inhibitors of which 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride is a potent in vitro and ex vivo inhibitor. 1-benzylpiperidine 66-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 1738151-1 1992 QSAR analyses have been performed on the substituted indanone and benzylpiperidine ring substructures of a set of acetylcholinesterase, AChE, inhibitors of which 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride is a potent in vitro and ex vivo inhibitor. 1-benzylpiperidine 66-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 1738151-1 1992 QSAR analyses have been performed on the substituted indanone and benzylpiperidine ring substructures of a set of acetylcholinesterase, AChE, inhibitors of which 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride is a potent in vitro and ex vivo inhibitor. 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride 162-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 1738151-1 1992 QSAR analyses have been performed on the substituted indanone and benzylpiperidine ring substructures of a set of acetylcholinesterase, AChE, inhibitors of which 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride is a potent in vitro and ex vivo inhibitor. 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride 162-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 2054485-4 1991 The decrease of acetylcholinesterase activity and the appearance of dystrophic and destructive changes both in the nerve fibers and in neurons was observed in the animals subjected to lasting ethanol effect for 60-90 days. Ethanol 192-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 34627797-1 2022 BACKGROUND: Organophosphates are insecticides that inhibit the enzymatic activity of acetylcholinesterase (AChE). Organophosphates 12-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 34627797-1 2022 BACKGROUND: Organophosphates are insecticides that inhibit the enzymatic activity of acetylcholinesterase (AChE). Organophosphates 12-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 34627797-2 2022 Because of this, AChE is considered a physiological marker of organophosphate exposure in agricultural settings. Organophosphates 62-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 34627797-3 2022 However, limited research exists on the associations between urinary organophosphate metabolites and AChE activity in children. Organophosphates 69-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 34627797-10 2022 Likewise, associations with AChE % change were significant only above the 80th percentile of TCPy (AChE % change per SD increase of metabolite = -1.38 % (95 %CI: 2.43 %, -0.32 %)) and PNP -2.47 % (95 %CI: 4.45 %, -0.50 %)). 3,5,6-trichloro-2-pyridinol 93-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 34627797-10 2022 Likewise, associations with AChE % change were significant only above the 80th percentile of TCPy (AChE % change per SD increase of metabolite = -1.38 % (95 %CI: 2.43 %, -0.32 %)) and PNP -2.47 % (95 %CI: 4.45 %, -0.50 %)). 3,5,6-trichloro-2-pyridinol 93-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 34627797-11 2022 PNP concentration at >=80th percentile was associated with elevated ORs for low AChE activity of 2.9 (95 % CI: 1.5, 5.7) and for AChE inhibition of <= -10 % of 3.7 (95 % CI: 1.4, 9.8). 4-nitrophenol 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 34627797-11 2022 PNP concentration at >=80th percentile was associated with elevated ORs for low AChE activity of 2.9 (95 % CI: 1.5, 5.7) and for AChE inhibition of <= -10 % of 3.7 (95 % CI: 1.4, 9.8). 4-nitrophenol 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 34627797-12 2022 CONCLUSIONS: Urinary organophosphate metabolites, including PNP, TCPy and MDA, particularly at concentrations above the 80th percentile, were associated with lower AChE activity among adolescents. Organophosphates 21-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 34627797-12 2022 CONCLUSIONS: Urinary organophosphate metabolites, including PNP, TCPy and MDA, particularly at concentrations above the 80th percentile, were associated with lower AChE activity among adolescents. 4-nitrophenol 60-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 34627797-12 2022 CONCLUSIONS: Urinary organophosphate metabolites, including PNP, TCPy and MDA, particularly at concentrations above the 80th percentile, were associated with lower AChE activity among adolescents. 3,5,6-trichloro-2-pyridinol 65-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 34627797-12 2022 CONCLUSIONS: Urinary organophosphate metabolites, including PNP, TCPy and MDA, particularly at concentrations above the 80th percentile, were associated with lower AChE activity among adolescents. mda 74-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 34865979-1 2022 A colorimetric gold nanoparticles (AuNPs)-based acetylcholinesterase (AChE) assay was designed for the first time to measure the concentration of parathion-methyl (PM) in lake water samples. Methyl Parathion 146-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 34865979-1 2022 A colorimetric gold nanoparticles (AuNPs)-based acetylcholinesterase (AChE) assay was designed for the first time to measure the concentration of parathion-methyl (PM) in lake water samples. Methyl Parathion 164-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 34865979-1 2022 A colorimetric gold nanoparticles (AuNPs)-based acetylcholinesterase (AChE) assay was designed for the first time to measure the concentration of parathion-methyl (PM) in lake water samples. Water 176-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 34865979-2 2022 In this assay, the analyte PM inhibited the hydrolysis of acetylthiocholine (ATCh) by AChE, preventing the formation of thiocholine (TCh) that would otherwise react with the AuNPs catalyst and deactivate the catalyst. Acetylthiocholine 58-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 34865979-2 2022 In this assay, the analyte PM inhibited the hydrolysis of acetylthiocholine (ATCh) by AChE, preventing the formation of thiocholine (TCh) that would otherwise react with the AuNPs catalyst and deactivate the catalyst. Acetylthiocholine 77-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 34865979-2 2022 In this assay, the analyte PM inhibited the hydrolysis of acetylthiocholine (ATCh) by AChE, preventing the formation of thiocholine (TCh) that would otherwise react with the AuNPs catalyst and deactivate the catalyst. Thiocholine 120-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 34865979-2 2022 In this assay, the analyte PM inhibited the hydrolysis of acetylthiocholine (ATCh) by AChE, preventing the formation of thiocholine (TCh) that would otherwise react with the AuNPs catalyst and deactivate the catalyst. Thiocholine 133-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 34865979-4 2022 However, in the absence of PM, AChE hydrolyzed ATCh to TCh, which then reacted with the AuNPs, preventing the oxidation of TMB to oxTMB and rendering the solution colorless. Thiocholine 55-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 34865979-4 2022 However, in the absence of PM, AChE hydrolyzed ATCh to TCh, which then reacted with the AuNPs, preventing the oxidation of TMB to oxTMB and rendering the solution colorless. 3,3',5,5'-tetramethylbenzidine 123-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 34865979-4 2022 However, in the absence of PM, AChE hydrolyzed ATCh to TCh, which then reacted with the AuNPs, preventing the oxidation of TMB to oxTMB and rendering the solution colorless. oxtmb 130-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 34968836-3 2022 In this system, OPs can suppress the activity of acetylcholinesterase (AChE) efficiently, blocking the hydrolysis reaction of acetylthiocholine (ATCh) to generate thiocholine (TCh) by AChE. OPS 16-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 34968836-3 2022 In this system, OPs can suppress the activity of acetylcholinesterase (AChE) efficiently, blocking the hydrolysis reaction of acetylthiocholine (ATCh) to generate thiocholine (TCh) by AChE. OPS 16-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 34968836-3 2022 In this system, OPs can suppress the activity of acetylcholinesterase (AChE) efficiently, blocking the hydrolysis reaction of acetylthiocholine (ATCh) to generate thiocholine (TCh) by AChE. OPS 16-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-188 34968836-3 2022 In this system, OPs can suppress the activity of acetylcholinesterase (AChE) efficiently, blocking the hydrolysis reaction of acetylthiocholine (ATCh) to generate thiocholine (TCh) by AChE. Acetylthiocholine 126-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 34968836-3 2022 In this system, OPs can suppress the activity of acetylcholinesterase (AChE) efficiently, blocking the hydrolysis reaction of acetylthiocholine (ATCh) to generate thiocholine (TCh) by AChE. Acetylthiocholine 126-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 34968836-3 2022 In this system, OPs can suppress the activity of acetylcholinesterase (AChE) efficiently, blocking the hydrolysis reaction of acetylthiocholine (ATCh) to generate thiocholine (TCh) by AChE. Acetylthiocholine 126-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-188 34968836-3 2022 In this system, OPs can suppress the activity of acetylcholinesterase (AChE) efficiently, blocking the hydrolysis reaction of acetylthiocholine (ATCh) to generate thiocholine (TCh) by AChE. Acetylthiocholine 145-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 34968836-3 2022 In this system, OPs can suppress the activity of acetylcholinesterase (AChE) efficiently, blocking the hydrolysis reaction of acetylthiocholine (ATCh) to generate thiocholine (TCh) by AChE. Acetylthiocholine 145-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 34968836-3 2022 In this system, OPs can suppress the activity of acetylcholinesterase (AChE) efficiently, blocking the hydrolysis reaction of acetylthiocholine (ATCh) to generate thiocholine (TCh) by AChE. Acetylthiocholine 145-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-188 34968836-3 2022 In this system, OPs can suppress the activity of acetylcholinesterase (AChE) efficiently, blocking the hydrolysis reaction of acetylthiocholine (ATCh) to generate thiocholine (TCh) by AChE. Thiocholine 163-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 34968836-3 2022 In this system, OPs can suppress the activity of acetylcholinesterase (AChE) efficiently, blocking the hydrolysis reaction of acetylthiocholine (ATCh) to generate thiocholine (TCh) by AChE. Thiocholine 163-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 34968836-3 2022 In this system, OPs can suppress the activity of acetylcholinesterase (AChE) efficiently, blocking the hydrolysis reaction of acetylthiocholine (ATCh) to generate thiocholine (TCh) by AChE. Thiocholine 163-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-188 34968836-3 2022 In this system, OPs can suppress the activity of acetylcholinesterase (AChE) efficiently, blocking the hydrolysis reaction of acetylthiocholine (ATCh) to generate thiocholine (TCh) by AChE. Thiocholine 176-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 34968836-3 2022 In this system, OPs can suppress the activity of acetylcholinesterase (AChE) efficiently, blocking the hydrolysis reaction of acetylthiocholine (ATCh) to generate thiocholine (TCh) by AChE. Thiocholine 176-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 34968836-3 2022 In this system, OPs can suppress the activity of acetylcholinesterase (AChE) efficiently, blocking the hydrolysis reaction of acetylthiocholine (ATCh) to generate thiocholine (TCh) by AChE. Thiocholine 176-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-188 34968952-3 2022 The principle of this biosensor relied on acetylcholinesterase (AChE)-catalyzed hydrolytic product-triggered disintegration of MnO2 nanosheets for releasing assistant DNA to initiate nicking enzyme-aided recycling amplification. manganese dioxide 127-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 34968952-3 2022 The principle of this biosensor relied on acetylcholinesterase (AChE)-catalyzed hydrolytic product-triggered disintegration of MnO2 nanosheets for releasing assistant DNA to initiate nicking enzyme-aided recycling amplification. manganese dioxide 127-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 34968952-4 2022 In the presence of OPs, the activity of AChE was inhibited and could not initiate the cleavage of the electroactive molecules-labeled hairpin probe on the electrode, resulting in the maintenance of the electrochemical response to realize a "sign-on" determination of OPs. OPS 19-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 34968952-4 2022 In the presence of OPs, the activity of AChE was inhibited and could not initiate the cleavage of the electroactive molecules-labeled hairpin probe on the electrode, resulting in the maintenance of the electrochemical response to realize a "sign-on" determination of OPs. OPS 267-270 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 34662796-4 2022 The fluorescence of S-CQDs was enhanced as the activity of acetylcholinesterase (AChE) was inhibited by pirimicarb, achieving the detection of pirimicarb in the cereal samples. pirimicarb 104-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 32890999-3 2020 In this work, we prepared a series of chalcones and 2"-aminochalcones, which were tested against AChE and BACE-1 enzymes and on the aggregation of Abeta. Chalcones 38-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 32890999-3 2020 In this work, we prepared a series of chalcones and 2"-aminochalcones, which were tested against AChE and BACE-1 enzymes and on the aggregation of Abeta. 2"-aminochalcones 52-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 34662796-4 2022 The fluorescence of S-CQDs was enhanced as the activity of acetylcholinesterase (AChE) was inhibited by pirimicarb, achieving the detection of pirimicarb in the cereal samples. pirimicarb 104-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 34662796-4 2022 The fluorescence of S-CQDs was enhanced as the activity of acetylcholinesterase (AChE) was inhibited by pirimicarb, achieving the detection of pirimicarb in the cereal samples. pirimicarb 143-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 34756920-2 2022 CPO is a potent inhibitor of acetylcholinesterase (AChE) and other serine hydrolases including fatty acid amide hydrolase (FAAH). O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 34862640-5 2022 Ki values of the secnidazole derivatives 1-30 for hCA I, hCA II, AChE, BChE, and alpha-glucosidase enzymes were obtained in the ranges of 47.37-190.74, 44.38-198.21, 12.14-68.37, 8.04-61.53, and 7.78-45.91 nM, respectively. secnidazole 17-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 34971946-3 2022 The in vitro assessment of the synthesized compounds revealed that all of them showed significant activity (IC50 ranging from 0.42 to 1.296 microM) towards AChE compared to the standard drug, galantamine (IC50 = 1.142 +- 0.027 microM). Galantamine 192-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-160 34756920-2 2022 CPO is a potent inhibitor of acetylcholinesterase (AChE) and other serine hydrolases including fatty acid amide hydrolase (FAAH). O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 34756920-3 2022 AChE is critical in regulating cholinergic signaling while FAAH catalyzes the inactivation of fatty acid signaling lipids including the endocannabinoid (eCB) N-arachidonylethanolamine (anandamide, AEA) and eCB-like metabolites (e.g., oleoylethanolamide, OEA). anandamide 185-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 34756920-3 2022 AChE is critical in regulating cholinergic signaling while FAAH catalyzes the inactivation of fatty acid signaling lipids including the endocannabinoid (eCB) N-arachidonylethanolamine (anandamide, AEA) and eCB-like metabolites (e.g., oleoylethanolamide, OEA). aea 197-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 34756920-3 2022 AChE is critical in regulating cholinergic signaling while FAAH catalyzes the inactivation of fatty acid signaling lipids including the endocannabinoid (eCB) N-arachidonylethanolamine (anandamide, AEA) and eCB-like metabolites (e.g., oleoylethanolamide, OEA). oleoylethanolamide 234-252 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 34756920-3 2022 AChE is critical in regulating cholinergic signaling while FAAH catalyzes the inactivation of fatty acid signaling lipids including the endocannabinoid (eCB) N-arachidonylethanolamine (anandamide, AEA) and eCB-like metabolites (e.g., oleoylethanolamide, OEA). N-oleoylethanolamine 254-257 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 34756920-6 2022 CPO elicited relatively similar concentration-dependent inhibition of both AChE and FAAH. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 34818764-5 2022 Chlorpyrifos increased mortality, growth rate and the energy consumed, and reduced the AChE (acetylcholinesterase) activity, the energy available, and the net energy budget (estimated as cellular energy allocation). Chlorpyrifos 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 34818764-5 2022 Chlorpyrifos increased mortality, growth rate and the energy consumed, and reduced the AChE (acetylcholinesterase) activity, the energy available, and the net energy budget (estimated as cellular energy allocation). Chlorpyrifos 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 34380107-3 2022 In this study the effect of different hydrolysis conditions on the properties of FPH to inhibit the enzyme acetylcholinesterase. 4'-hydroxyflurbiprofen 81-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 34380107-7 2022 Results showed a mixed type of inhibition behavior and, the docking molecular analyzes suggest that the inhibition AChE occurred due to the basic amino acids, mainly by arginine. Amino Acids, Basic 140-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 34380107-7 2022 Results showed a mixed type of inhibition behavior and, the docking molecular analyzes suggest that the inhibition AChE occurred due to the basic amino acids, mainly by arginine. Arginine 169-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 34666020-0 2022 Cytotoxic activity and influence on acetylcholinesterase of series dinuclear platinum(II) complexes with aromatic nitrogen-containing heterocyclic bridging ligands: Insights in the mechanisms of action. platinum(ii) 77-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 34666020-0 2022 Cytotoxic activity and influence on acetylcholinesterase of series dinuclear platinum(II) complexes with aromatic nitrogen-containing heterocyclic bridging ligands: Insights in the mechanisms of action. Nitrogen 114-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 34666020-7 2022 Pt1 showed similar inhibitory effects toward AChE as cisplatin, but a different type of inhibition, which could contribute to lower neurotoxicity. Cisplatin 53-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 34546589-2 2022 It is the target of various organophosphorus nerve agents and pesticides, and the inhibition of AChE is a therapeutic strategy for the treatment of various neurological-related diseases. organophosphorus 28-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 34969831-4 2022 To this end, a theophylline structure was connected to a pyrrolidine structure through a methylene chain of different lengths (3 to 7 carbon atoms) to give compounds 7-11 All caffeine derivatives inhibited the AChE, of which compound 11 showed the strongest effect. Carbon 134-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-214 34969831-4 2022 To this end, a theophylline structure was connected to a pyrrolidine structure through a methylene chain of different lengths (3 to 7 carbon atoms) to give compounds 7-11 All caffeine derivatives inhibited the AChE, of which compound 11 showed the strongest effect. Caffeine 175-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-214 34969831-9 2022 Thus, the new synthetized compounds can inhibit the AChE and activate muscle and alpha7 nAChRs with greater potency than caffeine, which suggests that they could be useful leaders for the development of new therapies for the treatment of different neurological diseases. Caffeine 121-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 34969831-10 2022 Significance Statement In this work we synthetized caffeine derivatives which can inhibit the AChE and activate both muscle and alpha7 nAChRs with higher potency than caffeine. Caffeine 51-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 34969831-10 2022 Significance Statement In this work we synthetized caffeine derivatives which can inhibit the AChE and activate both muscle and alpha7 nAChRs with higher potency than caffeine. Caffeine 167-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 34973350-6 2022 The results reveal, treatment with OSE, LEV and OSE+LEV significantly reversed the memory impairment, increases the BDNF expressions and decreases AChE activity in Abeta induced AD animals. serine O-sulfate 48-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 34973350-6 2022 The results reveal, treatment with OSE, LEV and OSE+LEV significantly reversed the memory impairment, increases the BDNF expressions and decreases AChE activity in Abeta induced AD animals. Levetiracetam 52-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 34966281-8 2021 Furthermore, huperzine A possessed a binding affinity of -8.7 kcal/mol with AChE and interacted within the active site of AChE via H-bonds and hydrophobic interactions. huperzine A 13-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 34966281-8 2021 Furthermore, huperzine A possessed a binding affinity of -8.7 kcal/mol with AChE and interacted within the active site of AChE via H-bonds and hydrophobic interactions. huperzine A 13-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 34893996-7 2022 The reference drug donepezil (IC50 = 0.021 microM) also displayed significant inhibition of AChE. Donepezil 19-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 34862575-0 2021 Fluorine-free synthesis of Ti3C2 MQDs for smartphone-based fluorescent and colorimetric determination of acetylcholinesterase and organophosphorus pesticides. Fluorine 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 34862575-3 2021 Acetylcholinesterase (AChE) could catalyze the hydrolysis of acetylthiocholine (ATCh) to produce thiocholine which was further reacted with Ehrman"s reagent and decomposed to form a yellow product 2-nitro-5-thiobenate anion (TNB). Acetylthiocholine 61-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 34862575-3 2021 Acetylcholinesterase (AChE) could catalyze the hydrolysis of acetylthiocholine (ATCh) to produce thiocholine which was further reacted with Ehrman"s reagent and decomposed to form a yellow product 2-nitro-5-thiobenate anion (TNB). Acetylthiocholine 61-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 34862575-3 2021 Acetylcholinesterase (AChE) could catalyze the hydrolysis of acetylthiocholine (ATCh) to produce thiocholine which was further reacted with Ehrman"s reagent and decomposed to form a yellow product 2-nitro-5-thiobenate anion (TNB). Thiocholine 97-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 34862575-3 2021 Acetylcholinesterase (AChE) could catalyze the hydrolysis of acetylthiocholine (ATCh) to produce thiocholine which was further reacted with Ehrman"s reagent and decomposed to form a yellow product 2-nitro-5-thiobenate anion (TNB). Thiocholine 97-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 34862575-3 2021 Acetylcholinesterase (AChE) could catalyze the hydrolysis of acetylthiocholine (ATCh) to produce thiocholine which was further reacted with Ehrman"s reagent and decomposed to form a yellow product 2-nitro-5-thiobenate anion (TNB). 2-nitro-5-thiobenate anion 197-223 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 34862575-3 2021 Acetylcholinesterase (AChE) could catalyze the hydrolysis of acetylthiocholine (ATCh) to produce thiocholine which was further reacted with Ehrman"s reagent and decomposed to form a yellow product 2-nitro-5-thiobenate anion (TNB). 2-nitro-5-thiobenate anion 197-223 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 34862575-3 2021 Acetylcholinesterase (AChE) could catalyze the hydrolysis of acetylthiocholine (ATCh) to produce thiocholine which was further reacted with Ehrman"s reagent and decomposed to form a yellow product 2-nitro-5-thiobenate anion (TNB). Trinitrobenzenesulfonic Acid 225-228 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 34862575-3 2021 Acetylcholinesterase (AChE) could catalyze the hydrolysis of acetylthiocholine (ATCh) to produce thiocholine which was further reacted with Ehrman"s reagent and decomposed to form a yellow product 2-nitro-5-thiobenate anion (TNB). Trinitrobenzenesulfonic Acid 225-228 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 34862575-4 2021 Due to the obvious overlap between the excitation spectrum of Ti3C2 MQDs and the absorption spectrum of TNB, AChE catalyzed the hydrolysis of substrate DTNB/ATCh to form TNB, which can effectively quench the fluorescence of Ti3C2 MQDs through the inner filter effect (IFE). Trinitrobenzenesulfonic Acid 104-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 34862575-4 2021 Due to the obvious overlap between the excitation spectrum of Ti3C2 MQDs and the absorption spectrum of TNB, AChE catalyzed the hydrolysis of substrate DTNB/ATCh to form TNB, which can effectively quench the fluorescence of Ti3C2 MQDs through the inner filter effect (IFE). Trinitrobenzenesulfonic Acid 170-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 34862575-5 2021 However, the presence of organophosphorus (OPs) inhibited the activity of AChE, leading to a less expressed IFE and increasing recovery of fluorescence. organophosphorus 25-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 34862575-5 2021 However, the presence of organophosphorus (OPs) inhibited the activity of AChE, leading to a less expressed IFE and increasing recovery of fluorescence. OPS 43-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 34884060-1 2021 Organophosphates (OPs) are neurotoxic agents also used as pesticides that can permanently block the active site of the acetylcholinesterase (AChE). Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 34884060-1 2021 Organophosphates (OPs) are neurotoxic agents also used as pesticides that can permanently block the active site of the acetylcholinesterase (AChE). Organophosphates 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 34884060-1 2021 Organophosphates (OPs) are neurotoxic agents also used as pesticides that can permanently block the active site of the acetylcholinesterase (AChE). Organophosphates 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 34569655-1 2021 New hybrid thiazolyl-pyrazoline derivatives (4a-k) were obtained through a facile and versatile synthetic procedure, and their inhibitory effects on the human carbonic anhydrase (hCA) isoforms I and II as well as on acetylcholinesterase (AChE) were determined. thiazolyl-pyrazoline 11-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 216-236 34569655-1 2021 New hybrid thiazolyl-pyrazoline derivatives (4a-k) were obtained through a facile and versatile synthetic procedure, and their inhibitory effects on the human carbonic anhydrase (hCA) isoforms I and II as well as on acetylcholinesterase (AChE) were determined. thiazolyl-pyrazoline 11-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 238-242 34569655-2 2021 All new thiazolyl-pyrazolines showed activity at nanomolar levels as hCA I, hCA II, and AChE inhibitors, with KI values in the range of 13.35-63.79, 7.01-115.80, and 17.89-48.05 nM, respectively. thiazolyl-pyrazolines 8-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 34749116-0 2021 Acylphloroglucinol trimers from Callistemon salignus seeds: Isolation, configurational assignment, hAChE inhibitory effects, and molecular docking studies. acylphloroglucinol 0-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-104 34561001-5 2021 The chloride-free, CM-CS-HAc demonstrated excellent buffering activity with Michaelis constants of 0.50 and 1.00 mM and maximum reaction rates of 5.62 and 2.26 mumol/min/mL for AChE and ALP reactions, respectively. Chlorides 4-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-181 34596972-8 2021 While 5-oxo-triazole piperidine-4-carboxamide moieties have a critical role in the inhibition of AChE and GST enzymes, hydroxy benzyl moiety is important for BChE enzyme inhibition. 5-oxo-triazole piperidine-4-carboxamide 6-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 34755546-4 2021 Molecular modeling studies of 5-chloro-1,7-dimethyl-substituted compound 8e were carried out to determine the possible binding interactions at the active site of AChE. 5-chloro-1,7-dimethyl 30-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-166 34755546-6 2021 The selectivity for AChE over BuChE of compound 8e was approximately 17-times higher than donepezil and 26-times higher than galantamine. Donepezil 90-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 34755546-6 2021 The selectivity for AChE over BuChE of compound 8e was approximately 17-times higher than donepezil and 26-times higher than galantamine. Galantamine 125-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 33243025-0 2021 Analogues of 2"-hydroxychalcone with modified C4-substituents as the inhibitors against human acetylcholinesterase. 2'-hydroxychalcone 13-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 25225806-0 2014 Distribution of intravenously administered acetylcholinesterase inhibitor and acetylcholinesterase activity in the adrenal gland: 11C-donepezil PET study in the normal rat. Donepezil C-11 130-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 34875277-0 2022 Interactions of human acetylcholinesterase with phenyl valerate and acetylthiocholine: Thiocholine as an enhancer of phenyl valerate esterase activity. phenyl valerate 48-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 34875277-0 2022 Interactions of human acetylcholinesterase with phenyl valerate and acetylthiocholine: Thiocholine as an enhancer of phenyl valerate esterase activity. Acetylthiocholine 68-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 34875277-0 2022 Interactions of human acetylcholinesterase with phenyl valerate and acetylthiocholine: Thiocholine as an enhancer of phenyl valerate esterase activity. Thiocholine 87-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 34875277-0 2022 Interactions of human acetylcholinesterase with phenyl valerate and acetylthiocholine: Thiocholine as an enhancer of phenyl valerate esterase activity. phenyl valerate 117-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 34609760-0 2022 Discovery of sulfadrug-pyrrole conjugates as carbonic anhydrase and acetylcholinesterase inhibitors. sulfadrug-pyrrole 13-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 34609760-5 2022 A novel series of pyrrole-3-one derivatives containing sulfa drugs (5a-i) were determined to be highly potent inhibitors for AChE and hCA I and hCA II (inhibitory constant (Ki ) values are in the range of 6.50 +- 1.02-37.46 +- 4.12 nM, 1.20 +- 0.19-44.21 +- 1.09 nM, and 8.93 +- 1.58-46.86 +- 8.41 nM for AChE, hCA I, and hCA II, respectively). pyrrole-3-one 18-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 34609760-5 2022 A novel series of pyrrole-3-one derivatives containing sulfa drugs (5a-i) were determined to be highly potent inhibitors for AChE and hCA I and hCA II (inhibitory constant (Ki ) values are in the range of 6.50 +- 1.02-37.46 +- 4.12 nM, 1.20 +- 0.19-44.21 +- 1.09 nM, and 8.93 +- 1.58-46.86 +- 8.41 nM for AChE, hCA I, and hCA II, respectively). pyrrole-3-one 18-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 305-309 34609760-5 2022 A novel series of pyrrole-3-one derivatives containing sulfa drugs (5a-i) were determined to be highly potent inhibitors for AChE and hCA I and hCA II (inhibitory constant (Ki ) values are in the range of 6.50 +- 1.02-37.46 +- 4.12 nM, 1.20 +- 0.19-44.21 +- 1.09 nM, and 8.93 +- 1.58-46.86 +- 8.41 nM for AChE, hCA I, and hCA II, respectively). sulfa 55-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 34609760-5 2022 A novel series of pyrrole-3-one derivatives containing sulfa drugs (5a-i) were determined to be highly potent inhibitors for AChE and hCA I and hCA II (inhibitory constant (Ki ) values are in the range of 6.50 +- 1.02-37.46 +- 4.12 nM, 1.20 +- 0.19-44.21 +- 1.09 nM, and 8.93 +- 1.58-46.86 +- 8.41 nM for AChE, hCA I, and hCA II, respectively). sulfa 55-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 305-309 34662731-5 2022 Steady-state kinetics of cholinesterase-catalyzed hydrolysis of PhA in the presence of ACh or ATC revealed 3 phases of inhibition as concentration of competitor increased: a) competitive inhibition, b) partially mixed inhibition, c) partially uncompetitive inhibition for AChE and partially uncompetitive activation for BChE. Acetylcholine 87-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 272-276 34662731-7 2022 In particular, it showed that binding of a competing ligand on PAS may affect the catalytic behavior of AChE and BChE in an opposite way, i.e. inhibition of AChE and activation of BChE, regardless the nature of the reporter substrate. Aminosalicylic Acid 63-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 34662731-7 2022 In particular, it showed that binding of a competing ligand on PAS may affect the catalytic behavior of AChE and BChE in an opposite way, i.e. inhibition of AChE and activation of BChE, regardless the nature of the reporter substrate. Aminosalicylic Acid 63-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 34414593-1 2022 Phenthoate is a chiral organophosphate pesticide with a pair of enantiomers which differ in toxicity, behavior, and insecticidal activity, and its acute toxicity on human health due to the inhibition of acetylcholinesterase highlights the need for enantioselective detection of enantiomers. phenthoate 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 203-223 34801945-0 2022 Design, Synthesis, biological investigations and molecular interactions of triazole linked tacrine glycoconjugates as Acetylcholinesterase inhibitors with reduced hepatotoxicity. Triazoles 75-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 34801945-0 2022 Design, Synthesis, biological investigations and molecular interactions of triazole linked tacrine glycoconjugates as Acetylcholinesterase inhibitors with reduced hepatotoxicity. Tacrine 91-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 34801945-1 2022 Tacrine is a known Acetylcholinesterase (AChE) inhibitors having hepatotoxicity as main liability associated with it. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 34801945-1 2022 Tacrine is a known Acetylcholinesterase (AChE) inhibitors having hepatotoxicity as main liability associated with it. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 34801945-3 2022 A series of triazole based glycoconjugates containing both acetylated (A-1 to A-7) and free sugar hydroxyl groups (A-8 to A-14) at the amino position of tacrine were synthesized in good yield taking aid from molecular docking studies and evaluated for their in vitro AChE inhibition activity as well as hepatotoxicity. Tacrine 153-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 267-271 34773872-2 2022 This scenario was to explore the stereoselective neurobiological response of human acetylcholinesterase (AChE) to chiral pyraclofos at the enantiomeric scale, and then decipher the microscopic basis of enantioselective neurotoxicity of pyraclofos enantiomers. pyraclofos 121-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 34773872-2 2022 This scenario was to explore the stereoselective neurobiological response of human acetylcholinesterase (AChE) to chiral pyraclofos at the enantiomeric scale, and then decipher the microscopic basis of enantioselective neurotoxicity of pyraclofos enantiomers. pyraclofos 236-246 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 34773872-3 2022 The results indicated that (R)-/(S)-pyraclofos can form the bioconjugates with AChE with a stoichiometric ratio of 1:1, but the neuronal affinity of (R)-pyraclofos (K = 6.31 x 104 M-1) with AChE was larger than that of (S)-pyraclofos (K = 1.86 x 104 M-1), and significant enantioselectivity was existed in the biochemical reaction. (r)-/(s)-pyraclofos 27-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 34773872-3 2022 The results indicated that (R)-/(S)-pyraclofos can form the bioconjugates with AChE with a stoichiometric ratio of 1:1, but the neuronal affinity of (R)-pyraclofos (K = 6.31 x 104 M-1) with AChE was larger than that of (S)-pyraclofos (K = 1.86 x 104 M-1), and significant enantioselectivity was existed in the biochemical reaction. (r)-/(s)-pyraclofos 27-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 190-194 34773872-3 2022 The results indicated that (R)-/(S)-pyraclofos can form the bioconjugates with AChE with a stoichiometric ratio of 1:1, but the neuronal affinity of (R)-pyraclofos (K = 6.31 x 104 M-1) with AChE was larger than that of (S)-pyraclofos (K = 1.86 x 104 M-1), and significant enantioselectivity was existed in the biochemical reaction. (r)-pyraclofos 149-163 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 34773872-3 2022 The results indicated that (R)-/(S)-pyraclofos can form the bioconjugates with AChE with a stoichiometric ratio of 1:1, but the neuronal affinity of (R)-pyraclofos (K = 6.31 x 104 M-1) with AChE was larger than that of (S)-pyraclofos (K = 1.86 x 104 M-1), and significant enantioselectivity was existed in the biochemical reaction. (r)-pyraclofos 149-163 acetylcholinesterase (Cartwright blood group) Homo sapiens 190-194 34773872-3 2022 The results indicated that (R)-/(S)-pyraclofos can form the bioconjugates with AChE with a stoichiometric ratio of 1:1, but the neuronal affinity of (R)-pyraclofos (K = 6.31 x 104 M-1) with AChE was larger than that of (S)-pyraclofos (K = 1.86 x 104 M-1), and significant enantioselectivity was existed in the biochemical reaction. pyraclofos 219-233 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 34773872-6 2022 Energy decomposition exhibited that the Gibbs free energies of the AChE-(R)-/(S)-pyraclofos were DeltaG = -37.4/-30.2 kJ mol-1, respectively, and the disparity comes from the electrostatic energy during the stereoselective neurochemical reactions. Arginine 72-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 34773872-6 2022 Energy decomposition exhibited that the Gibbs free energies of the AChE-(R)-/(S)-pyraclofos were DeltaG = -37.4/-30.2 kJ mol-1, respectively, and the disparity comes from the electrostatic energy during the stereoselective neurochemical reactions. pyraclofos 77-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 34773872-7 2022 Quantitative conformational analysis further confirmed the atomic-scale computational chemistry conclusions, and the perturbation of (S)-pyraclofos on the AChE"s ordered conformation was lower than that of (R)-pyraclofos, which is germane to the interaction energies of the crucial residues, e.g. Tyr-124, Tyr-337, Asp-74, Trp-86, and Tyr-119. pyraclofos 133-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 34773872-7 2022 Quantitative conformational analysis further confirmed the atomic-scale computational chemistry conclusions, and the perturbation of (S)-pyraclofos on the AChE"s ordered conformation was lower than that of (R)-pyraclofos, which is germane to the interaction energies of the crucial residues, e.g. Tyr-124, Tyr-337, Asp-74, Trp-86, and Tyr-119. Tyrosine 297-300 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 34773872-7 2022 Quantitative conformational analysis further confirmed the atomic-scale computational chemistry conclusions, and the perturbation of (S)-pyraclofos on the AChE"s ordered conformation was lower than that of (R)-pyraclofos, which is germane to the interaction energies of the crucial residues, e.g. Tyr-124, Tyr-337, Asp-74, Trp-86, and Tyr-119. Tyrosine 306-309 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 34773872-7 2022 Quantitative conformational analysis further confirmed the atomic-scale computational chemistry conclusions, and the perturbation of (S)-pyraclofos on the AChE"s ordered conformation was lower than that of (R)-pyraclofos, which is germane to the interaction energies of the crucial residues, e.g. Tyr-124, Tyr-337, Asp-74, Trp-86, and Tyr-119. Aspartic Acid 315-318 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 34773872-7 2022 Quantitative conformational analysis further confirmed the atomic-scale computational chemistry conclusions, and the perturbation of (S)-pyraclofos on the AChE"s ordered conformation was lower than that of (R)-pyraclofos, which is germane to the interaction energies of the crucial residues, e.g. Tyr-124, Tyr-337, Asp-74, Trp-86, and Tyr-119. Tryptophan 323-326 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 34773872-7 2022 Quantitative conformational analysis further confirmed the atomic-scale computational chemistry conclusions, and the perturbation of (S)-pyraclofos on the AChE"s ordered conformation was lower than that of (R)-pyraclofos, which is germane to the interaction energies of the crucial residues, e.g. Tyr-124, Tyr-337, Asp-74, Trp-86, and Tyr-119. Tyrosine 335-338 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 34969831-3 2022 Given that caffeine is a natural compound that behaves as an AChE inhibitor and as a partial agonist of nAChRs, the aim of this work was to synthetize more potent bifunctional caffeine analogs that modulate these two molecular targets. Caffeine 11-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 34969831-3 2022 Given that caffeine is a natural compound that behaves as an AChE inhibitor and as a partial agonist of nAChRs, the aim of this work was to synthetize more potent bifunctional caffeine analogs that modulate these two molecular targets. Caffeine 176-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 34969831-4 2022 To this end, a theophylline structure was connected to a pyrrolidine structure through a methylene chain of different lengths (3 to 7 carbon atoms) to give compounds 7-11 All caffeine derivatives inhibited the AChE, of which compound 11 showed the strongest effect. Theophylline 15-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-214 34969831-4 2022 To this end, a theophylline structure was connected to a pyrrolidine structure through a methylene chain of different lengths (3 to 7 carbon atoms) to give compounds 7-11 All caffeine derivatives inhibited the AChE, of which compound 11 showed the strongest effect. pyrrolidine 57-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-214 34973350-6 2022 The results reveal, treatment with OSE, LEV and OSE+LEV significantly reversed the memory impairment, increases the BDNF expressions and decreases AChE activity in Abeta induced AD animals. serine O-sulfate 35-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 34973350-6 2022 The results reveal, treatment with OSE, LEV and OSE+LEV significantly reversed the memory impairment, increases the BDNF expressions and decreases AChE activity in Abeta induced AD animals. Levetiracetam 40-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 34961331-11 2022 AChE concentration was reduced in individuals with PD compared with control subjects in dorsal and ventral BA 18 and dorsal BA 19, and it was increased in ventral BA 19. Barium 163-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 34931332-0 2022 Design, synthesis, biological activity, molecular docking, and molecular dynamics of novel benzimidazole derivatives as potential AChE/MAO-B dual inhibitors. benzimidazole 91-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 34931332-1 2022 To develop new acetylcholinesterase (AChE)-monoamine oxidase-B (MAO-B) dual inhibitors against Alzheimer"s disease, the benzimidazole ring, which has a propargyl side chain with previously proven selective MAO-B inhibitory activity, was used as the main structure. benzimidazole 120-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 34931332-1 2022 To develop new acetylcholinesterase (AChE)-monoamine oxidase-B (MAO-B) dual inhibitors against Alzheimer"s disease, the benzimidazole ring, which has a propargyl side chain with previously proven selective MAO-B inhibitory activity, was used as the main structure. benzimidazole 120-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 34931332-2 2022 Moreover, like donepezil, it was thought that the enzyme AChE would provide pi-pi interactions with the peripheral anionic side in this structure. Donepezil 15-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 34931332-7 2022 As a result of activity tests, compounds 5b, 5e, 5g, and 5h showed inhibitory activity against AChE; compounds 5e and 5g showed inhibitory activity against MAO-B. 5h 57-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 34927331-4 2022 Acetylcholinesterase inhibitors, such as neostigmine and pyridostigmine, delay the degradation of acetylcholine at the synaptic cleft. Neostigmine 41-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 34927331-4 2022 Acetylcholinesterase inhibitors, such as neostigmine and pyridostigmine, delay the degradation of acetylcholine at the synaptic cleft. Pyridostigmine Bromide 57-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 34927331-4 2022 Acetylcholinesterase inhibitors, such as neostigmine and pyridostigmine, delay the degradation of acetylcholine at the synaptic cleft. Acetylcholine 98-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 34808043-0 2021 Binding Mechanism between Acetylcholinesterase and Drugs Pazopanib and Lapatinib: Biochemical and Biophysical Studies. pazopanib 57-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 34808043-0 2021 Binding Mechanism between Acetylcholinesterase and Drugs Pazopanib and Lapatinib: Biochemical and Biophysical Studies. Lapatinib 71-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 34808043-3 2021 In this work, interaction and inhibition studies through spectroscopic and computational techniques to evaluate the binding effectiveness of lapatinib and pazopanib TKIs to acetylcholinesterase (AChE) are reported. Lapatinib 141-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-193 34808043-3 2021 In this work, interaction and inhibition studies through spectroscopic and computational techniques to evaluate the binding effectiveness of lapatinib and pazopanib TKIs to acetylcholinesterase (AChE) are reported. Lapatinib 141-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 34808043-3 2021 In this work, interaction and inhibition studies through spectroscopic and computational techniques to evaluate the binding effectiveness of lapatinib and pazopanib TKIs to acetylcholinesterase (AChE) are reported. pazopanib 155-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-193 34808043-3 2021 In this work, interaction and inhibition studies through spectroscopic and computational techniques to evaluate the binding effectiveness of lapatinib and pazopanib TKIs to acetylcholinesterase (AChE) are reported. pazopanib 155-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 34808043-6 2021 The fluorescence suppression studies indicate a static mechanism for lapatinib-AChE and pazopanib-AChE systems, with a binding constant in the order of 105 M-1. Lapatinib 69-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 34808043-6 2021 The fluorescence suppression studies indicate a static mechanism for lapatinib-AChE and pazopanib-AChE systems, with a binding constant in the order of 105 M-1. Lapatinib 69-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 34808043-6 2021 The fluorescence suppression studies indicate a static mechanism for lapatinib-AChE and pazopanib-AChE systems, with a binding constant in the order of 105 M-1. pazopanib 88-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 34808043-7 2021 The obtained thermodynamic parameters reveal interactions driven by van der Waals forces and hydrogen bonds in the lapatinib-AChE system (DeltaH and DeltaS < 0). Hydrogen 93-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 34808043-7 2021 The obtained thermodynamic parameters reveal interactions driven by van der Waals forces and hydrogen bonds in the lapatinib-AChE system (DeltaH and DeltaS < 0). Lapatinib 115-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 34808043-8 2021 In contrast, the pazopanib-AChE system shows positive DeltaH and DeltaS , characteristic of hydrophobic interactions. pazopanib 17-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 34740688-0 2021 Deciphering the AChE-binding mechanism with multifunctional tricyclic coumarin anti-Alzheimer"s agents using biophysical and bioinformatics approaches and evaluation of their modulating effect on Amyloidogenic peptide assembly. coumarin 70-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 34740688-4 2021 Hence, the present study aims to examine the effect of multifunctional fused tricyclic 7-hydroxy 4-methy coumarin analogs (HMC1-5) on the self-induced aggregation of beta-amyloid using Thioflavin T (ThT) assay, scanning electron microscopic study, AlamarBlue and immune blotting assays and also the binding mechanism with AChE by fluorescence emission, conformational, molecular docking and molecular dynamic simulation studies under physiological pH 7.4. 7-hydroxy 4-methy coumarin 87-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 322-326 34740688-7 2021 CD studies disclosed a partial unfolding in the secondary structure of AChE upon binding with HMC1-5. Cadmium 0-2 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 34907850-7 2021 Where these drugs, with the exception of memantine, are inhibitors of acetylcholinesterase, thus inhibiting the enzyme that destroys acetylcholine, thus increasing the availability of this neurotransmitter. Memantine 41-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 34907850-7 2021 Where these drugs, with the exception of memantine, are inhibitors of acetylcholinesterase, thus inhibiting the enzyme that destroys acetylcholine, thus increasing the availability of this neurotransmitter. Acetylcholine 133-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 34907850-12 2021 Amentoflavone has the ability to inhibit acetylcholinesterase when tested in vitro, having an IC50 of 8.68 +- 0.73 microg/mL, corroborating its effect in the in silico test, presenting four strong covalent hydrogen bonds for having a bond length up to 2.5 A. amentoflavone 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 34907850-12 2021 Amentoflavone has the ability to inhibit acetylcholinesterase when tested in vitro, having an IC50 of 8.68 +- 0.73 microg/mL, corroborating its effect in the in silico test, presenting four strong covalent hydrogen bonds for having a bond length up to 2.5 A. Hydrogen 206-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 34944045-0 2021 Exploring the Binding Pattern of Geraniol with Acetylcholinesterase through In Silico Docking, Molecular Dynamics Simulation, and In Vitro Enzyme Inhibition Kinetics Studies. geraniol 33-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 34944045-2 2021 Here, the inhibitory potential of geraniol and its mechanism of inhibition against AChE were elucidated in vitro and validated via an in silico study. geraniol 34-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 34944045-3 2021 Our in vitro enzyme inhibition kinetics results show that at increasing concentrations of geraniol and substrate, Vmax did not change significantly, but Km increased, which indicates that geraniol is a competitive inhibitor against AChE with an IC50 value 98.06 +- 3.92 microM. geraniol 90-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 232-236 34944045-3 2021 Our in vitro enzyme inhibition kinetics results show that at increasing concentrations of geraniol and substrate, Vmax did not change significantly, but Km increased, which indicates that geraniol is a competitive inhibitor against AChE with an IC50 value 98.06 +- 3.92 microM. geraniol 188-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 232-236 34944045-5 2021 A docking study showed that the binding energy of geraniol (-5.6 kcal mol-1) was lower than that of acetylcholine (-4.1 kcal mol-1) with AChE, which exhibited around a 12.58-fold higher binding affinity of geraniol. geraniol 50-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 34944045-5 2021 A docking study showed that the binding energy of geraniol (-5.6 kcal mol-1) was lower than that of acetylcholine (-4.1 kcal mol-1) with AChE, which exhibited around a 12.58-fold higher binding affinity of geraniol. Acetylcholine 100-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 34944045-5 2021 A docking study showed that the binding energy of geraniol (-5.6 kcal mol-1) was lower than that of acetylcholine (-4.1 kcal mol-1) with AChE, which exhibited around a 12.58-fold higher binding affinity of geraniol. geraniol 206-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 34944045-6 2021 Furthermore, molecular dynamics simulation revealed that the RMSD of AChE alone or in complex with geraniol fluctuated within acceptable limits throughout the simulation. geraniol 99-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 34944045-10 2021 These findings suggest that geraniol remained inside the binding cavity of AChE in a stable conformation. geraniol 28-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 33243025-1 2021 A series of C4-substituted tertiary nitrogen-bearing 2"-hydroxychalcones were designed and synthesised based on a previous mixed type acetylcholinesterase inhibitor. Nitrogen 36-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 33243025-1 2021 A series of C4-substituted tertiary nitrogen-bearing 2"-hydroxychalcones were designed and synthesised based on a previous mixed type acetylcholinesterase inhibitor. 2'-hydroxychalcone 53-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 33243025-2 2021 Majority of the 2"-hydroxychalcone analogues displayed a better inhibition against acetylcholinesterase (AChE) than butyrylcholinesterase (BuChE). 2'-hydroxychalcone 16-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 33243025-2 2021 Majority of the 2"-hydroxychalcone analogues displayed a better inhibition against acetylcholinesterase (AChE) than butyrylcholinesterase (BuChE). 2'-hydroxychalcone 16-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 33478277-2 2021 In the present study, we used three docking-based virtual screening approaches to screen both ZINC15 and MolPort databases for synthetic analogs of physostigmine and donepezil, two highly potent AChE inhibitors. Physostigmine 148-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 33478277-2 2021 In the present study, we used three docking-based virtual screening approaches to screen both ZINC15 and MolPort databases for synthetic analogs of physostigmine and donepezil, two highly potent AChE inhibitors. Donepezil 166-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 33557647-0 2021 New 3-O-substituted xanthone derivatives as promising acetylcholinesterase inhibitors. 3-o-substituted xanthone 4-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 33557647-1 2021 A new series of 3-O-substituted xanthone derivatives were synthesised and evaluated for their anti-cholinergic activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). 3-o-substituted xanthone 16-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 33557647-1 2021 A new series of 3-O-substituted xanthone derivatives were synthesised and evaluated for their anti-cholinergic activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). 3-o-substituted xanthone 16-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 33557647-4 2021 Molecular docking study showed that 23 binds to the active site of AChE and interacts via extensive pi-pi stacking with the indole and phenol side chains of Trp86 and Tyr337, besides the hydrogen bonding with the hydration site and pi-pi interaction with the phenol side chain of Y72. indole 124-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 33557647-4 2021 Molecular docking study showed that 23 binds to the active site of AChE and interacts via extensive pi-pi stacking with the indole and phenol side chains of Trp86 and Tyr337, besides the hydrogen bonding with the hydration site and pi-pi interaction with the phenol side chain of Y72. Phenol 135-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 33557647-4 2021 Molecular docking study showed that 23 binds to the active site of AChE and interacts via extensive pi-pi stacking with the indole and phenol side chains of Trp86 and Tyr337, besides the hydrogen bonding with the hydration site and pi-pi interaction with the phenol side chain of Y72. Hydrogen 187-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 33557647-4 2021 Molecular docking study showed that 23 binds to the active site of AChE and interacts via extensive pi-pi stacking with the indole and phenol side chains of Trp86 and Tyr337, besides the hydrogen bonding with the hydration site and pi-pi interaction with the phenol side chain of Y72. Phenol 259-265 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 33557647-5 2021 This study revealed that 3-O-alkoxyl substituted xanthone derivatives are potential lead structures, especially 23 and 28 which can be further developed into potent AChE inhibitors. 3-o-alkoxyl 25-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 33557647-5 2021 This study revealed that 3-O-alkoxyl substituted xanthone derivatives are potential lead structures, especially 23 and 28 which can be further developed into potent AChE inhibitors. xanthone 49-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 34134572-6 2021 The IC50 value of compound 20 against acetylcholinesterase inhibition (0.086 +- 0.01 micromol L-1) is similar to donepezil (0.085 +- 0.01 micromol L-1) and is better than baicalein (0.404 +- 0.04 micromol L-1). baicalein 171-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 34808511-8 2021 Water fluoride concentrations were positively associated with AChE and negatively associated with ChAT and ACh, trends were same for urinary fluoride except for ACh. Water 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 34294013-0 2021 Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase. Tacrine 15-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 34294013-2 2021 The multivalent inhibition potencies for the tacrine clusters were investigated for the inhibition of acetylcholinesterase. Tacrine 45-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 34880083-0 2021 Correction to "Tacrine Induces Endoplasmic Reticulum-Stressed Apoptosis via Disrupting the Proper Assembly of Oligomeric Acetylcholinesterase in Cultured Neuronal Cells". Tacrine 15-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 34269114-2 2021 BChE plays a critical role in maintaining normal cholinergic function like acetylcholinesterase (AChE) through hydrolyzing acetylcholine (ACh). Acetylcholine 123-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 34269114-2 2021 BChE plays a critical role in maintaining normal cholinergic function like acetylcholinesterase (AChE) through hydrolyzing acetylcholine (ACh). Acetylcholine 138-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 34517642-0 2021 A near-infrared light triggered fluormetric biosensor for sensitive detection of acetylcholinesterase activity based on NaErF4: 0.5 % Ho3+@NaYF4 upconversion nano-probe. naerf4 120-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 34517642-0 2021 A near-infrared light triggered fluormetric biosensor for sensitive detection of acetylcholinesterase activity based on NaErF4: 0.5 % Ho3+@NaYF4 upconversion nano-probe. ho3+ 134-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 34517642-0 2021 A near-infrared light triggered fluormetric biosensor for sensitive detection of acetylcholinesterase activity based on NaErF4: 0.5 % Ho3+@NaYF4 upconversion nano-probe. nayf4 139-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 34517642-3 2021 Herein, we developed a facile and interference-free fluorimetric biosensing platform for highly sensitive AChE activity determination based on a NaErF4: 0.5 % Ho3+@NaYF4 nano-probe. naerf4 145-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 34517642-3 2021 Herein, we developed a facile and interference-free fluorimetric biosensing platform for highly sensitive AChE activity determination based on a NaErF4: 0.5 % Ho3+@NaYF4 nano-probe. ho3+ 159-163 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 34517642-3 2021 Herein, we developed a facile and interference-free fluorimetric biosensing platform for highly sensitive AChE activity determination based on a NaErF4: 0.5 % Ho3+@NaYF4 nano-probe. nayf4 164-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 34517642-5 2021 The principle of this detection relies on the quenching of the strong monochromic red UC emission by oxidization products of 3,3",5,5"-tetramethylbenzidine generated through AChE-modulated cascade reactions. 3,3',5,5'-tetramethylbenzidine 125-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 34517656-5 2021 With acetylcholine chloride (ACh) as substrate of acetylcholinesterase (AChE), a CL method was exploited for sensitive detection of organophosphorus pesticide triazophos due to its irreversible inhibiting effect on the AChE activity and subsequently influences the production of H2O2 under the condition of choline oxidase (ChOx). Acetylcholine 5-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 34517656-5 2021 With acetylcholine chloride (ACh) as substrate of acetylcholinesterase (AChE), a CL method was exploited for sensitive detection of organophosphorus pesticide triazophos due to its irreversible inhibiting effect on the AChE activity and subsequently influences the production of H2O2 under the condition of choline oxidase (ChOx). Acetylcholine 5-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 34517656-5 2021 With acetylcholine chloride (ACh) as substrate of acetylcholinesterase (AChE), a CL method was exploited for sensitive detection of organophosphorus pesticide triazophos due to its irreversible inhibiting effect on the AChE activity and subsequently influences the production of H2O2 under the condition of choline oxidase (ChOx). Acetylcholine 5-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 219-223 34517656-5 2021 With acetylcholine chloride (ACh) as substrate of acetylcholinesterase (AChE), a CL method was exploited for sensitive detection of organophosphorus pesticide triazophos due to its irreversible inhibiting effect on the AChE activity and subsequently influences the production of H2O2 under the condition of choline oxidase (ChOx). Acetylcholine 29-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 34517656-5 2021 With acetylcholine chloride (ACh) as substrate of acetylcholinesterase (AChE), a CL method was exploited for sensitive detection of organophosphorus pesticide triazophos due to its irreversible inhibiting effect on the AChE activity and subsequently influences the production of H2O2 under the condition of choline oxidase (ChOx). Acetylcholine 29-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 34517656-5 2021 With acetylcholine chloride (ACh) as substrate of acetylcholinesterase (AChE), a CL method was exploited for sensitive detection of organophosphorus pesticide triazophos due to its irreversible inhibiting effect on the AChE activity and subsequently influences the production of H2O2 under the condition of choline oxidase (ChOx). Acetylcholine 29-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 219-223 34517656-5 2021 With acetylcholine chloride (ACh) as substrate of acetylcholinesterase (AChE), a CL method was exploited for sensitive detection of organophosphorus pesticide triazophos due to its irreversible inhibiting effect on the AChE activity and subsequently influences the production of H2O2 under the condition of choline oxidase (ChOx). organophosphorus 132-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 34517656-5 2021 With acetylcholine chloride (ACh) as substrate of acetylcholinesterase (AChE), a CL method was exploited for sensitive detection of organophosphorus pesticide triazophos due to its irreversible inhibiting effect on the AChE activity and subsequently influences the production of H2O2 under the condition of choline oxidase (ChOx). organophosphorus 132-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 34517656-5 2021 With acetylcholine chloride (ACh) as substrate of acetylcholinesterase (AChE), a CL method was exploited for sensitive detection of organophosphorus pesticide triazophos due to its irreversible inhibiting effect on the AChE activity and subsequently influences the production of H2O2 under the condition of choline oxidase (ChOx). organophosphorus 132-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 219-223 34517656-5 2021 With acetylcholine chloride (ACh) as substrate of acetylcholinesterase (AChE), a CL method was exploited for sensitive detection of organophosphorus pesticide triazophos due to its irreversible inhibiting effect on the AChE activity and subsequently influences the production of H2O2 under the condition of choline oxidase (ChOx). triazophos 159-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 34517656-5 2021 With acetylcholine chloride (ACh) as substrate of acetylcholinesterase (AChE), a CL method was exploited for sensitive detection of organophosphorus pesticide triazophos due to its irreversible inhibiting effect on the AChE activity and subsequently influences the production of H2O2 under the condition of choline oxidase (ChOx). triazophos 159-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 34517656-5 2021 With acetylcholine chloride (ACh) as substrate of acetylcholinesterase (AChE), a CL method was exploited for sensitive detection of organophosphorus pesticide triazophos due to its irreversible inhibiting effect on the AChE activity and subsequently influences the production of H2O2 under the condition of choline oxidase (ChOx). triazophos 159-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 219-223 34517656-5 2021 With acetylcholine chloride (ACh) as substrate of acetylcholinesterase (AChE), a CL method was exploited for sensitive detection of organophosphorus pesticide triazophos due to its irreversible inhibiting effect on the AChE activity and subsequently influences the production of H2O2 under the condition of choline oxidase (ChOx). Hydrogen Peroxide 279-283 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 34517656-5 2021 With acetylcholine chloride (ACh) as substrate of acetylcholinesterase (AChE), a CL method was exploited for sensitive detection of organophosphorus pesticide triazophos due to its irreversible inhibiting effect on the AChE activity and subsequently influences the production of H2O2 under the condition of choline oxidase (ChOx). Hydrogen Peroxide 279-283 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 34887704-0 2021 Synthesis and Evaluation of the Acetylcholinesterase Inhibitory Activities of Some Flavonoids Derived from Naringenin. Flavonoids 83-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 34887704-0 2021 Synthesis and Evaluation of the Acetylcholinesterase Inhibitory Activities of Some Flavonoids Derived from Naringenin. naringenin 107-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 34887704-5 2021 Naringenin is a flavonoid with the potential inhibitory activity against AChE. naringenin 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 34887704-8 2021 The evaluation of AChE inhibitory activity by the Ellman method showed that there were four substances (2, 4, 5, and 7) with relatively good biological activities (IC50 < 100 muM), and these biological activities were better than that of naringenin. naringenin 238-248 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 34841804-7 2021 The concentration of 20 mug/mL graphene oxide with the size >5 mum (LGO) increased the activity of acetylcholinesterase by 42.67% (P<0.05). graphene oxide 31-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 34884060-0 2021 Colorimetric Detection of Organophosphate Pesticides Based on Acetylcholinesterase and Cysteamine Capped Gold Nanoparticles as Nanozyme. Organophosphates 26-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 34884060-1 2021 Organophosphates (OPs) are neurotoxic agents also used as pesticides that can permanently block the active site of the acetylcholinesterase (AChE). Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 34783117-3 2022 The synthesized nitrogen-based novel heterocyclic compounds were evaluated against the human carbonic anhydrase isoenzymes I and II (hCA I and hCA II), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzymes. Nitrogen 16-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 34783117-3 2022 The synthesized nitrogen-based novel heterocyclic compounds were evaluated against the human carbonic anhydrase isoenzymes I and II (hCA I and hCA II), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzymes. Nitrogen 16-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 34783117-4 2022 The synthesized nitrogen-based novel heterocyclic compounds showed IC50 values in the range of 2.69-7.01 against hCA I, 2.40-4.59 against hCA II, 0.81-1.32 microM against AChE, and 20.83-1.70 microM against BChE enzymes. Nitrogen 16-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 34783117-5 2022 On the contrary, nitrogen-based novel heterocyclic compounds demonstrated Ki values between 2.93 +- 0.59-8.61 +- 1.39 against hCA I, 2.05 +- 0.62-4.97 +- 0.95 against hCA II, 0.34 +- 0.02-0.92 +- 0.17 nM against AChE, and 0.50 +- 0.04-1.20 +- 0.16 microM against BChE enzymes. Nitrogen 17-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 212-216 34825172-2 2021 When diazinon residues enter the human body, it functions as an acetylcholinesterase (AChE) inhibitor. Diazinon 5-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 34825172-2 2021 When diazinon residues enter the human body, it functions as an acetylcholinesterase (AChE) inhibitor. Diazinon 5-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 34888010-2 2021 The main action of organophosphate focuses on acetylcholinesterase inhibition, and it therefore contributes to acute cholinergic crisis, intermediate syndrome and delayed neurotoxicity. Organophosphates 19-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 34832929-1 2021 The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by organophosphates (OPs) as nerve agents and pesticides compromises normal cholinergic nerve signal transduction in the peripheral and central nervous systems (CNS) leading to cholinergic crisis. Organophosphates 82-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 34832929-1 2021 The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by organophosphates (OPs) as nerve agents and pesticides compromises normal cholinergic nerve signal transduction in the peripheral and central nervous systems (CNS) leading to cholinergic crisis. Organophosphates 82-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 34832929-1 2021 The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by organophosphates (OPs) as nerve agents and pesticides compromises normal cholinergic nerve signal transduction in the peripheral and central nervous systems (CNS) leading to cholinergic crisis. Organophosphates 100-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 34832929-1 2021 The inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by organophosphates (OPs) as nerve agents and pesticides compromises normal cholinergic nerve signal transduction in the peripheral and central nervous systems (CNS) leading to cholinergic crisis. Organophosphates 100-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 34714045-0 2021 Sensitivity Dependence on the Crystal Forms of a Fluorescence Quencher for Silicon Quantum Dots and Its Use in Acetylcholinesterase Assay. Silicon 75-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 34714045-4 2021 It is interesting that the sensitivity of AChE sensing is closely related to the crystal forms of FeOOH, with the highest sensitivity by adopting alpha-FeOOH as the quencher. feooh 98-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 34714045-4 2021 It is interesting that the sensitivity of AChE sensing is closely related to the crystal forms of FeOOH, with the highest sensitivity by adopting alpha-FeOOH as the quencher. goethite 146-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 34831318-4 2021 In SH-SY5Y cells expressing the GFP-tagged Abeta-folding reporter, both ZN compounds reduced Abeta aggregation, oxidative stress, activities of caspase-1 and AChE, as well as increased neurite outgrowth. Zinc 72-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 34832918-0 2021 The Potential Effect of Insulin on AChE and Its Interactions with Rivastigmine In Vitro. Rivastigmine 66-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 34832918-2 2021 Drugs that inhibit acetylcholinesterase (AChE), such as rivastigmine, are promising symptomatic treatments for AD. Rivastigmine 56-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 34832918-2 2021 Drugs that inhibit acetylcholinesterase (AChE), such as rivastigmine, are promising symptomatic treatments for AD. Rivastigmine 56-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 34832918-10 2021 However, to improve our understanding of the possible interaction of insulin and rivastigmine, or its target AChE, more in silico modelling and in vivo studies are needed. Rivastigmine 81-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 34743300-10 2021 The Schiff base ligand was discovered to be the best inhibitor for the AChE and BChE with the values of 7.13 +- 0.84 microM and 5.75 +- 1.03 microM Ki, respectively. Schiff Bases 4-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 34743300-13 2021 The metal complexes demonstrated better binding affinities with the AChE, BChE, and GST enzymes than the Schiff base ligand. Metals 4-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 34743300-13 2021 The metal complexes demonstrated better binding affinities with the AChE, BChE, and GST enzymes than the Schiff base ligand. Schiff Bases 105-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 34743300-14 2021 This study identified a potential Schiff base molecule against both AChE and BChE targets to further investigate for in vivo and safety evaluation. Schiff Bases 34-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 34198150-5 2021 In this study, we characterized a new backbone of the AChE/GSK3beta inhibitor 11c. Carbon-11 78-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 34198150-6 2021 It was identified as a highly potent AChE inhibitor and was found superior to donepezil, the first-line drug for the treatment of AD. Donepezil 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 34198150-7 2021 In vivo studies confirmed that 11c significantly inhibited the activity of AChE in the brain but had little effect on the activity of AChE in the intestine. Carbon-11 31-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 34342141-0 2021 Homarine alkyl esters derivatives as new promising acetylcholinesterase inhibitors. homarine alkyl esters 0-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 34643082-1 2021 To obtain a multipotent framework that can target simultaneously COX-2, 5-LOX, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) to treat neuroinflammation, a series of derivatives containing pyrimidine and pyrrolidine cores were rationally synthesized and evaluated. pyrimidine 204-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 34643082-1 2021 To obtain a multipotent framework that can target simultaneously COX-2, 5-LOX, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) to treat neuroinflammation, a series of derivatives containing pyrimidine and pyrrolidine cores were rationally synthesized and evaluated. pyrimidine 204-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 34643082-1 2021 To obtain a multipotent framework that can target simultaneously COX-2, 5-LOX, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) to treat neuroinflammation, a series of derivatives containing pyrimidine and pyrrolidine cores were rationally synthesized and evaluated. pyrrolidine 219-230 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 34643082-1 2021 To obtain a multipotent framework that can target simultaneously COX-2, 5-LOX, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) to treat neuroinflammation, a series of derivatives containing pyrimidine and pyrrolidine cores were rationally synthesized and evaluated. pyrrolidine 219-230 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 34636548-4 2021 In addition, molecular docking results revealed that the cations and organic anions of ILs bound to specific amino acid residues of AChE through noncovalent interactions such as pi interactions and hydrogen bonds. Hydrogen 198-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 34728713-0 2021 Assessment of four organophosphorus pesticides as inhibitors of human acetylcholinesterase and butyrylcholinesterase. organophosphorus 19-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-116 34625266-4 2021 Acetylcholinesterase (AChE) catalyzes the hydrolysis of acetylcholine (ATCh) to produce thiocholine (TCh). Acetylcholine 56-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 34625266-4 2021 Acetylcholinesterase (AChE) catalyzes the hydrolysis of acetylcholine (ATCh) to produce thiocholine (TCh). Acetylcholine 56-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 34625266-4 2021 Acetylcholinesterase (AChE) catalyzes the hydrolysis of acetylcholine (ATCh) to produce thiocholine (TCh). Thiocholine 88-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 34625266-4 2021 Acetylcholinesterase (AChE) catalyzes the hydrolysis of acetylcholine (ATCh) to produce thiocholine (TCh). Thiocholine 88-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 34625266-4 2021 Acetylcholinesterase (AChE) catalyzes the hydrolysis of acetylcholine (ATCh) to produce thiocholine (TCh). Thiocholine 101-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 34625266-4 2021 Acetylcholinesterase (AChE) catalyzes the hydrolysis of acetylcholine (ATCh) to produce thiocholine (TCh). Thiocholine 101-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 34625266-6 2021 Organophosphorus pesticides (OPs) can inhibit the activity of AChE enzymes, thereby preventing the production of TCh and the decomposition of MnO2 nanosheets, resulting in the fluorescence "turn-off". organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 34625266-6 2021 Organophosphorus pesticides (OPs) can inhibit the activity of AChE enzymes, thereby preventing the production of TCh and the decomposition of MnO2 nanosheets, resulting in the fluorescence "turn-off". Thiocholine 113-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 34625266-6 2021 Organophosphorus pesticides (OPs) can inhibit the activity of AChE enzymes, thereby preventing the production of TCh and the decomposition of MnO2 nanosheets, resulting in the fluorescence "turn-off". manganese dioxide 142-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 34625266-7 2021 Therefore, the concentration of OPs can be detected by measuring the fluorescence intensity change of AChE-ATCh-MnO2-BCNO-QDs system. OPS 32-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 34625266-7 2021 Therefore, the concentration of OPs can be detected by measuring the fluorescence intensity change of AChE-ATCh-MnO2-BCNO-QDs system. Acetylcholine 107-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 34625266-7 2021 Therefore, the concentration of OPs can be detected by measuring the fluorescence intensity change of AChE-ATCh-MnO2-BCNO-QDs system. manganese dioxide 112-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 34625266-7 2021 Therefore, the concentration of OPs can be detected by measuring the fluorescence intensity change of AChE-ATCh-MnO2-BCNO-QDs system. bcno 117-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 34625266-7 2021 Therefore, the concentration of OPs can be detected by measuring the fluorescence intensity change of AChE-ATCh-MnO2-BCNO-QDs system. qds 122-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 34555506-3 2021 Thus, in the current study, twenty-eight new derivatives of montanine-type Amaryllidaceae alkaloids were synthesized and evaluated for their ability to inhibit human recombinant acetylcholinesterase (hAChE) and butyrylcholinesterase (hBuChE). montanine-type amaryllidaceae alkaloids 60-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-205 34555506-4 2021 Three derivatives (1n, 1o, and 1p) with different substitution patterns demonstrated significant selective inhibitory potency for hAChE (IC50 < 5 microM), and one analog, 1v, showed selective hBuChE inhibition activity (IC50 = 1.73 +- 0.05 microM). 1P 31-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-135 34562674-0 2021 Dual targeting of acetylcholinesterase and tau aggregation: Design, synthesis and evaluation of multifunctional deoxyvasicinone analogues for Alzheimer"s disease. 2,3-trimethylene-4-quinazolone 112-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 34562674-2 2021 Herein, we reported a new series of deoxyvasicinone analogues as dual inhibitor of acetylcholinesterase (AChE) and tau aggregation that function as multitargeted ligands for AD. 2,3-trimethylene-4-quinazolone 36-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 34562674-2 2021 Herein, we reported a new series of deoxyvasicinone analogues as dual inhibitor of acetylcholinesterase (AChE) and tau aggregation that function as multitargeted ligands for AD. 2,3-trimethylene-4-quinazolone 36-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 34562674-7 2021 Among all compounds, 11f remarkably inhibited AChE activity and cellular tau oligomerization at single-dose screening (10 microM). 5-[(3s)-3-(2-Methoxybiphenyl-4-Yl)but-1-Yn-1-Yl]-6-Methylpyrimidine-2,4-Diamine 21-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 34562674-8 2021 Moreover, 11f displayed a half-maximal inhibitory concentration (IC50) value of 0.91 +- 0.05 microM and half-maximal effective concentration (EC50) value of 3.83 +- 0.51 microM for the inhibition of AChE and cellular tau oligomerization, respectively. 5-[(3s)-3-(2-Methoxybiphenyl-4-Yl)but-1-Yn-1-Yl]-6-Methylpyrimidine-2,4-Diamine 10-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-203 34628223-3 2021 Derivative 5f (IC50 = 0.86 +- 0.08 microM), 5g (IC50 = 1.05 +- 0.06 microM) and 5d (IC50 = 1.64 +- 0.06 microM) exhibited higher AChE inhibitory activity as compared to standard drug galantamine (IC50 = 2.15 +- 0.05 microM). Galantamine 183-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 34808511-10 2021 The mediation proportion by AChE between water fluoride and either developing DF or IQ < 120 was 15.7%. Water 41-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 34547176-0 2021 Tailored Modeling of Rivastigmine Derivatives as Dual Acetylcholinesterase and Butyrylcholinesterase Inhibitors for Alzheimer"s Disease Treatment. Rivastigmine 21-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 34547176-2 2021 Herein, we integrate computational and theoretical methodologies to unveil rivastigmine derivatives as dual inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) for Alzheimer"s disease (AD) management. Rivastigmine 75-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 34547176-2 2021 Herein, we integrate computational and theoretical methodologies to unveil rivastigmine derivatives as dual inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) for Alzheimer"s disease (AD) management. Rivastigmine 75-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 34547176-7 2021 The study revealed RL2 (4-fluorophenyl rivastigmine) as a potential dual inhibitor for AChE and BuChE towards Alzheimer"s disorder management. RL2 19-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 34547176-7 2021 The study revealed RL2 (4-fluorophenyl rivastigmine) as a potential dual inhibitor for AChE and BuChE towards Alzheimer"s disorder management. 4-fluorophenyl rivastigmine 24-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 34363318-0 2021 Structural Fractal Analysis of the Active Site of Acetylcholinesterase in Complexes with Huperzine A, Galantamine, and Donepezil. huperzine A 89-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 34399231-0 2021 Probing the acetylcholinesterase inhibitory activity of a novel Ru(II) polypyridyl complex and the supramolecular interaction by (STD)-NMR. ru(ii) polypyridyl complex 64-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 34399231-4 2021 Here we describe the synthesis, characterization, biological activity and an NMR binding-target study of a novel cis-(Ru(Bpy)2(EtPy)2)2+, (RuEtPy), Bpy = 2,2"-bipyridine and EtPy = 4,2-Ethylamino-pyridine) as a potential AChE inhibitor. cis-(ru(bpy)2(etpy)2)2+ 113-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 221-225 34399231-4 2021 Here we describe the synthesis, characterization, biological activity and an NMR binding-target study of a novel cis-(Ru(Bpy)2(EtPy)2)2+, (RuEtPy), Bpy = 2,2"-bipyridine and EtPy = 4,2-Ethylamino-pyridine) as a potential AChE inhibitor. 2,2'-Dipyridyl 148-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 221-225 34399231-4 2021 Here we describe the synthesis, characterization, biological activity and an NMR binding-target study of a novel cis-(Ru(Bpy)2(EtPy)2)2+, (RuEtPy), Bpy = 2,2"-bipyridine and EtPy = 4,2-Ethylamino-pyridine) as a potential AChE inhibitor. 2,2'-Dipyridyl 154-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 221-225 34399231-4 2021 Here we describe the synthesis, characterization, biological activity and an NMR binding-target study of a novel cis-(Ru(Bpy)2(EtPy)2)2+, (RuEtPy), Bpy = 2,2"-bipyridine and EtPy = 4,2-Ethylamino-pyridine) as a potential AChE inhibitor. etpy 174-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 221-225 34399231-4 2021 Here we describe the synthesis, characterization, biological activity and an NMR binding-target study of a novel cis-(Ru(Bpy)2(EtPy)2)2+, (RuEtPy), Bpy = 2,2"-bipyridine and EtPy = 4,2-Ethylamino-pyridine) as a potential AChE inhibitor. 4,2-ethylamino-pyridine 181-204 acetylcholinesterase (Cartwright blood group) Homo sapiens 221-225 34225093-3 2021 These agents mainly irreversibly inhibit the action of acetylcholinesterase, an enzyme that breaks down acetylcholine, a neurotransmitter, and are believed to cause acute symptoms of poisoning. Acetylcholine 104-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 34363318-0 2021 Structural Fractal Analysis of the Active Site of Acetylcholinesterase in Complexes with Huperzine A, Galantamine, and Donepezil. Galantamine 102-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 34363318-0 2021 Structural Fractal Analysis of the Active Site of Acetylcholinesterase in Complexes with Huperzine A, Galantamine, and Donepezil. Donepezil 119-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 34363318-1 2021 The fractal dimension (D) of the active site of hAChE in the unliganded state and as part of complexes with hyperzine A, galantamine, and donepezil is calculated using molecular interatomic-distance histograms. hyperzine a 108-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-53 34363318-1 2021 The fractal dimension (D) of the active site of hAChE in the unliganded state and as part of complexes with hyperzine A, galantamine, and donepezil is calculated using molecular interatomic-distance histograms. Galantamine 121-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-53 34363318-1 2021 The fractal dimension (D) of the active site of hAChE in the unliganded state and as part of complexes with hyperzine A, galantamine, and donepezil is calculated using molecular interatomic-distance histograms. Donepezil 138-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-53 34606227-13 2021 Finally, the loss of cholinergic transmission mediated by the neurotransmitter acetylcholine (ACh) contributes to cognitive deficits observed in AD.In this Account, we illustrate the design principles for small-molecule-based chemical tools with reactivities against metal-free Abeta, metal-bound Abeta, ROS, and AChE. Acetylcholine 79-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 313-317 34531295-0 2021 Tacrine induces endoplasmic reticulum-stressed apoptosis via disrupting the proper assembly of oligomeric acetylcholinesterase in cultured neuronal cells. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 34531295-4 2021 Here, we found tacrine could disrupt the proper trafficking of proline-rich membrane anchor-linked tetrameric AChE in the endoplasmic reticulum (ER). Tacrine 15-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 34531295-4 2021 Here, we found tacrine could disrupt the proper trafficking of proline-rich membrane anchor-linked tetrameric AChE in the endoplasmic reticulum (ER). Proline 63-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 34531295-5 2021 The exposure of tacrine in cells expressing AChE, e.g. neuron, caused an accumulation of the misfolded AChE in the ER. Tacrine 16-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 34531295-5 2021 The exposure of tacrine in cells expressing AChE, e.g. neuron, caused an accumulation of the misfolded AChE in the ER. Tacrine 16-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 34531295-9 2021 The ER stress and apoptosis, induced by tacrine, were proportional to the amount of AChE. Tacrine 40-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 34531295-13 2021 Our study reports tacrine and other AChEIs disrupt the proper trafficking of AChE in the endoplasmic reticulum. Tacrine 18-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 34714861-10 2021 A significant difference in enzyme activity of the catalytic site mutants was observed as compared to the wildtype, and subsequent AChE activity showed that esterase activity of PON2 is responsible for the hydrolysis of DHC and PB. Donepezil 220-223 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 34714861-10 2021 A significant difference in enzyme activity of the catalytic site mutants was observed as compared to the wildtype, and subsequent AChE activity showed that esterase activity of PON2 is responsible for the hydrolysis of DHC and PB. Pyridostigmine Bromide 228-230 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 34821676-4 2021 A mechanistic mathematical model of the biosensor was used to simulate key diffusion and reaction steps, including diffusion of AChE"s reactant (phenylacetate) and inhibitor, the reaction kinetics of the two enzymes, and electrochemical reaction kinetics at the SPE"s working electrode. phenylacetic acid 145-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 34606227-13 2021 Finally, the loss of cholinergic transmission mediated by the neurotransmitter acetylcholine (ACh) contributes to cognitive deficits observed in AD.In this Account, we illustrate the design principles for small-molecule-based chemical tools with reactivities against metal-free Abeta, metal-bound Abeta, ROS, and AChE. Acetylcholine 94-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 313-317 34606227-18 2021 Finally, inhibiting substrate access or substrate binding at the active site of AChE can diminish its activity, which restores the levels of ACh. Acetylcholine 141-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 34664067-8 2021 UHPLC-fourier-transform mass spectrometry detection results revealed that five alkaloids showed obvious AChE inhibitory activities including coptisin, epiberberine, jatrorrhizine, berberine and palmatine. Alkaloids 79-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 34664067-8 2021 UHPLC-fourier-transform mass spectrometry detection results revealed that five alkaloids showed obvious AChE inhibitory activities including coptisin, epiberberine, jatrorrhizine, berberine and palmatine. coptisine 141-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 34664067-8 2021 UHPLC-fourier-transform mass spectrometry detection results revealed that five alkaloids showed obvious AChE inhibitory activities including coptisin, epiberberine, jatrorrhizine, berberine and palmatine. epiberberine 151-163 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 34664067-8 2021 UHPLC-fourier-transform mass spectrometry detection results revealed that five alkaloids showed obvious AChE inhibitory activities including coptisin, epiberberine, jatrorrhizine, berberine and palmatine. palmatine 194-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 34664067-9 2021 The relative AChE inhibitory activities of jatrorrhizine, berberine and palmatine in the Coptidis Rhizoma sample were equal to that of 257.0, 2355 and 283.9 mug/mL of galanthamine, respectively. Berberine 58-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 34664067-9 2021 The relative AChE inhibitory activities of jatrorrhizine, berberine and palmatine in the Coptidis Rhizoma sample were equal to that of 257.0, 2355 and 283.9 mug/mL of galanthamine, respectively. palmatine 72-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 34664067-9 2021 The relative AChE inhibitory activities of jatrorrhizine, berberine and palmatine in the Coptidis Rhizoma sample were equal to that of 257.0, 2355 and 283.9 mug/mL of galanthamine, respectively. Galantamine 167-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 34637466-3 2021 The associated changes in the cholinergic components may be reflected by intra- or extra-cellular ACh levels, with an increase in extracellular ACh levels occurring following AChE inhibition. Acetylcholine 144-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 175-179 34637466-9 2021 RESULTS: Our cell-based assay system was capable of detecting increases in extracellular ACh levels induced by an AChE inhibitor at relatively high doses, as well as increases in intracellular ACh levels following the administration of lower AChE-inhibitor doses and an mAChR agonist. Acetylcholine 89-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 34637466-9 2021 RESULTS: Our cell-based assay system was capable of detecting increases in extracellular ACh levels induced by an AChE inhibitor at relatively high doses, as well as increases in intracellular ACh levels following the administration of lower AChE-inhibitor doses and an mAChR agonist. Acetylcholine 193-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 242-246 34637680-0 2021 Probing the intermolecular interactions, binding affinity, charge density distribution and dynamics of silibinin in dual targets AChE and BACE1: QTAIM and molecular dynamics perspective. Silybin 103-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 34637680-3 2021 An experimental study reports that silibinin molecule inhibits both AChE and BACE1 enzymes. Silybin 35-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 34637680-4 2021 Present study aims to understand the dual binding mechanism of silibinin in the active site of AChE and BACE1 from the intermolecular interactions, conformational flexibility, charge density distribution, binding energy and the stability of molecule. Silybin 63-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 34637680-8 2021 The electrostatic potential map displays the electronegative/positive regions at the interaction zone of silibinin with AChE and BACE1 complexes. Silybin 105-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 34637680-9 2021 The MD simulation confirms that the silibinin molecule is stable in the active site of AChE and BACE1 enzymes. Silybin 36-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 34609711-3 2022 Acetylcholinesterase (AChE) hydrolyses ACh and inhibits the cholinergic transmission. Acetylcholine 39-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 34609711-3 2022 Acetylcholinesterase (AChE) hydrolyses ACh and inhibits the cholinergic transmission. Acetylcholine 39-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 34153471-2 2021 These analogs of deoxyvasicinone-indole were evaluated as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), and as inhibitors of amyloid aggregation (Abeta1-42) for treatment of Alzheimer"s disease (AD). deoxyvasicinone-indole 17-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 34153471-2 2021 These analogs of deoxyvasicinone-indole were evaluated as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), and as inhibitors of amyloid aggregation (Abeta1-42) for treatment of Alzheimer"s disease (AD). deoxyvasicinone-indole 17-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 34612677-1 2021 BACKGROUND: To date, the toxicity of organophosphate esters has primarily been studied regarding their use as pesticides and their effects on the neurotransmitter acetylcholinesterase (AChE). organophosphate esters 37-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 185-189 34506764-0 2021 alpha-tocopherol, a slow-binding inhibitor of acetylcholinesterase. alpha-Tocopherol 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 34506764-1 2021 Acetylcholinesterase (AChE) is reversibly inhibited by alpha-tocopherol (alpha-T). alpha-Tocopherol 55-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 34506764-1 2021 Acetylcholinesterase (AChE) is reversibly inhibited by alpha-tocopherol (alpha-T). alpha-Tocopherol 55-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 34506764-1 2021 Acetylcholinesterase (AChE) is reversibly inhibited by alpha-tocopherol (alpha-T). alpha-Tocopherol 73-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 34506764-1 2021 Acetylcholinesterase (AChE) is reversibly inhibited by alpha-tocopherol (alpha-T). alpha-Tocopherol 73-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 34506764-4 2021 alpha-T slightly modulates the progressive inhibition of AChE by the cyclic organophosphorus, cresyl saligenylphosphate, accelerating the fast pseudo-first order process of phosphorylation. alpha-Tocopherol 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 34506764-4 2021 alpha-T slightly modulates the progressive inhibition of AChE by the cyclic organophosphorus, cresyl saligenylphosphate, accelerating the fast pseudo-first order process of phosphorylation. cyclic organophosphorus 69-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 34506764-4 2021 alpha-T slightly modulates the progressive inhibition of AChE by the cyclic organophosphorus, cresyl saligenylphosphate, accelerating the fast pseudo-first order process of phosphorylation. cresyl saligenylphosphate 94-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 34506764-5 2021 A moderate accelerating effect of alpha-T on phosphorylation by paraoxon was also observed after pre-incubation of AChE in the presence of alpha-T. Paraoxon 64-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 34506764-7 2021 The effect of alpha-T on AChE phosphylation was interpreted in light of molecular modeling results. alpha-Tocopherol 14-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 34474201-5 2021 The novel substituted benzylamines derived from dihydrochalcones were evaluated against some enzymes such as human erythrocyte carbonic anhydrase I and II isoenzymes (hCA I and hCA II), acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Benzylamines 22-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-206 34474201-5 2021 The novel substituted benzylamines derived from dihydrochalcones were evaluated against some enzymes such as human erythrocyte carbonic anhydrase I and II isoenzymes (hCA I and hCA II), acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). dihydrochalcone 48-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-206 34612677-5 2021 OBJECTIVES: This commentary describes research on the non-AChE neurodevelopmental toxicity of organophosphate esters used as flame retardants and plasticizers (OPEs). organophosphate esters 94-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 34602041-1 2022 Acetylcholinesterase (AchE), hydrolase enzyme, regulates the hydrolysis of acetylcholine neurotransmitter in the neurons. Acetylcholine 75-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 34390751-0 2021 Exploring indole-based-thiadiazole derivatives as potent acetylcholinesterase and butyrylcholinesterase enzyme inhibitors. indole 10-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 34390751-0 2021 Exploring indole-based-thiadiazole derivatives as potent acetylcholinesterase and butyrylcholinesterase enzyme inhibitors. Thiadiazoles 23-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 34390751-1 2021 Indole based thiadiazole derivatives (1-18) were synthesized and evaluated for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition. indole 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 34981029-7 2021 Results: Emamectin benzoate (EMB) treatment induced oxidative stress by increased levels of Malondialdehyde (MDA), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) with inhibition of acetylcholinesterase (AChE), Superoxide dismutase (SOD) and Catalase (CAT) levels. emamectin benzoate 9-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-222 34981029-7 2021 Results: Emamectin benzoate (EMB) treatment induced oxidative stress by increased levels of Malondialdehyde (MDA), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) with inhibition of acetylcholinesterase (AChE), Superoxide dismutase (SOD) and Catalase (CAT) levels. emamectin benzoate 9-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 224-228 34981029-7 2021 Results: Emamectin benzoate (EMB) treatment induced oxidative stress by increased levels of Malondialdehyde (MDA), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) with inhibition of acetylcholinesterase (AChE), Superoxide dismutase (SOD) and Catalase (CAT) levels. emamectin benzoate 29-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-222 34981029-7 2021 Results: Emamectin benzoate (EMB) treatment induced oxidative stress by increased levels of Malondialdehyde (MDA), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) with inhibition of acetylcholinesterase (AChE), Superoxide dismutase (SOD) and Catalase (CAT) levels. emamectin benzoate 29-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 224-228 34623807-3 2021 In the detection system, thiocholine (Tch), the hydrolysis product of thioacetylcholine (ATch) by acetylcholinesterase (AchE), could trigger the aggregation of CTAB-Au NPs, resulting in a significant color change from red to purple. Thiocholine 25-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-118 34623807-3 2021 In the detection system, thiocholine (Tch), the hydrolysis product of thioacetylcholine (ATch) by acetylcholinesterase (AchE), could trigger the aggregation of CTAB-Au NPs, resulting in a significant color change from red to purple. Thiocholine 25-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 34623807-3 2021 In the detection system, thiocholine (Tch), the hydrolysis product of thioacetylcholine (ATch) by acetylcholinesterase (AchE), could trigger the aggregation of CTAB-Au NPs, resulting in a significant color change from red to purple. Thiocholine 38-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-118 34623807-3 2021 In the detection system, thiocholine (Tch), the hydrolysis product of thioacetylcholine (ATch) by acetylcholinesterase (AchE), could trigger the aggregation of CTAB-Au NPs, resulting in a significant color change from red to purple. Thiocholine 38-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 34623807-3 2021 In the detection system, thiocholine (Tch), the hydrolysis product of thioacetylcholine (ATch) by acetylcholinesterase (AchE), could trigger the aggregation of CTAB-Au NPs, resulting in a significant color change from red to purple. thioacetylcholine 70-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-118 34623807-3 2021 In the detection system, thiocholine (Tch), the hydrolysis product of thioacetylcholine (ATch) by acetylcholinesterase (AchE), could trigger the aggregation of CTAB-Au NPs, resulting in a significant color change from red to purple. thioacetylcholine 70-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 34623807-3 2021 In the detection system, thiocholine (Tch), the hydrolysis product of thioacetylcholine (ATch) by acetylcholinesterase (AchE), could trigger the aggregation of CTAB-Au NPs, resulting in a significant color change from red to purple. ctab-au 160-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-118 34623807-3 2021 In the detection system, thiocholine (Tch), the hydrolysis product of thioacetylcholine (ATch) by acetylcholinesterase (AchE), could trigger the aggregation of CTAB-Au NPs, resulting in a significant color change from red to purple. ctab-au 160-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 34623807-6 2021 Thus, based on the inhibition of AChE activity by OPs, a colorimetric and fluorescent dual-mode platform was constructed for on-site detection of OPs. OPS 50-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 34558680-0 2022 Caged Oxime Reactivators Designed for the Light Control of Acetylcholinesterase Reactivation. Oximes 6-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 34581863-2 2021 To design highly active acetylcholinesterase inhibitors, a three-dimensional quantitative structure-activity relationship (3D-QSAR) approach was performed on a series of N-benzylpyrrolidine derivatives previously evaluated for acetylcholinesterase inhibitory activity. 1-Benzylpyrrolidine 170-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 34185362-1 2021 Nerve agents are tetrahedral organophosphorus compounds (OPs) that were developed in the last century to irreversibly inhibit acetylcholinesterase (AChE) and therefore impede neurological signaling in living organisms. Organophosphorus Compounds 29-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 34185362-1 2021 Nerve agents are tetrahedral organophosphorus compounds (OPs) that were developed in the last century to irreversibly inhibit acetylcholinesterase (AChE) and therefore impede neurological signaling in living organisms. Organophosphorus Compounds 29-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 34185362-1 2021 Nerve agents are tetrahedral organophosphorus compounds (OPs) that were developed in the last century to irreversibly inhibit acetylcholinesterase (AChE) and therefore impede neurological signaling in living organisms. Organophosphorus Compounds 57-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 34185362-1 2021 Nerve agents are tetrahedral organophosphorus compounds (OPs) that were developed in the last century to irreversibly inhibit acetylcholinesterase (AChE) and therefore impede neurological signaling in living organisms. Organophosphorus Compounds 57-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 34374289-0 2021 Metabolism-Coupled Cell-Independent Acetylcholinesterase Activity Assay for Evaluation of the Effects of Chlorination on Diazinon Toxicity. Diazinon 121-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 34374289-2 2021 The toxicological end point for determining the acceptable daily intake of most organophosphorus insecticides is inhibition of acetylcholinesterase (AChE). organophosphorus 80-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 34374289-2 2021 The toxicological end point for determining the acceptable daily intake of most organophosphorus insecticides is inhibition of acetylcholinesterase (AChE). organophosphorus 80-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 34374289-4 2021 Here, we incorporated metabolism into a cell-independent AChE activity assay and then evaluated the change in anti-AChE activity during chlorination of a solution containing the organophosphorus insecticide diazinon. Diazinon 207-215 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 34374289-5 2021 The anti-AChE activities of solutions of diazinon or diazinon-oxon, the major transformation product of diazinon during chlorination, were dramatically changed by metabolism: the activity of diazinon solution was markedly increased, whereas that of diazinon-oxon solution was slightly decreased, clearly indicating the importance of incorporating metabolism into assays examining toxicity after oral ingestion. Diazinon 41-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 34374289-5 2021 The anti-AChE activities of solutions of diazinon or diazinon-oxon, the major transformation product of diazinon during chlorination, were dramatically changed by metabolism: the activity of diazinon solution was markedly increased, whereas that of diazinon-oxon solution was slightly decreased, clearly indicating the importance of incorporating metabolism into assays examining toxicity after oral ingestion. diazoxon 53-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 34374289-5 2021 The anti-AChE activities of solutions of diazinon or diazinon-oxon, the major transformation product of diazinon during chlorination, were dramatically changed by metabolism: the activity of diazinon solution was markedly increased, whereas that of diazinon-oxon solution was slightly decreased, clearly indicating the importance of incorporating metabolism into assays examining toxicity after oral ingestion. Diazinon 104-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 34374289-5 2021 The anti-AChE activities of solutions of diazinon or diazinon-oxon, the major transformation product of diazinon during chlorination, were dramatically changed by metabolism: the activity of diazinon solution was markedly increased, whereas that of diazinon-oxon solution was slightly decreased, clearly indicating the importance of incorporating metabolism into assays examining toxicity after oral ingestion. Diazinon 191-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 34374289-5 2021 The anti-AChE activities of solutions of diazinon or diazinon-oxon, the major transformation product of diazinon during chlorination, were dramatically changed by metabolism: the activity of diazinon solution was markedly increased, whereas that of diazinon-oxon solution was slightly decreased, clearly indicating the importance of incorporating metabolism into assays examining toxicity after oral ingestion. diazoxon 249-262 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 34374289-8 2021 In contrast, with metabolism, diazinon solution did show anti-AChE activity before chlorination, but chlorination gradually decreased this activity over time. Diazinon 30-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 34374289-9 2021 The observed anti-AChE activities were attributable solely to diazinon and diazinon-oxon having been contained in the samples before metabolism, clearly suggesting that the presence not only of diazinon but also of diazinon-oxon should be monitored in drinking water. Diazinon 62-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 34374289-9 2021 The observed anti-AChE activities were attributable solely to diazinon and diazinon-oxon having been contained in the samples before metabolism, clearly suggesting that the presence not only of diazinon but also of diazinon-oxon should be monitored in drinking water. diazoxon 75-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 34374289-9 2021 The observed anti-AChE activities were attributable solely to diazinon and diazinon-oxon having been contained in the samples before metabolism, clearly suggesting that the presence not only of diazinon but also of diazinon-oxon should be monitored in drinking water. Diazinon 194-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 34374289-9 2021 The observed anti-AChE activities were attributable solely to diazinon and diazinon-oxon having been contained in the samples before metabolism, clearly suggesting that the presence not only of diazinon but also of diazinon-oxon should be monitored in drinking water. diazoxon 215-228 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 34391122-3 2021 Inhibitors of acetylcholinesterase (AChE) and ionotropic glutamate receptors of the N-methyl-d-aspartate (NMDA) receptor family are currently approved as AD therapeutics. N-Methylaspartate 84-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 34391122-3 2021 Inhibitors of acetylcholinesterase (AChE) and ionotropic glutamate receptors of the N-methyl-d-aspartate (NMDA) receptor family are currently approved as AD therapeutics. N-Methylaspartate 106-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 34391122-7 2021 These compounds were superior to the previously characterized bis-gamma-carbolinium conjugates because they blocked NMDA receptors without requiring a quaternary pyridine N-atom and inhibited AChE with moderate IC50 values of 0.54-5.3 microM. bis-gamma-carbolinium 62-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 34576998-6 2021 The synthesized conjugates showed new properties compared to their prototypes (memantine and dimebon), including the ability to bind to the ifenprodil-binding site of the NMDA receptor and to occupy the peripheral anionic site of acetylcholinesterase (AChE), which indicates that these compounds can act as blockers of AChE-induced beta-amyloid aggregation. Memantine 79-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 230-250 34576998-6 2021 The synthesized conjugates showed new properties compared to their prototypes (memantine and dimebon), including the ability to bind to the ifenprodil-binding site of the NMDA receptor and to occupy the peripheral anionic site of acetylcholinesterase (AChE), which indicates that these compounds can act as blockers of AChE-induced beta-amyloid aggregation. Memantine 79-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 252-256 34576998-6 2021 The synthesized conjugates showed new properties compared to their prototypes (memantine and dimebon), including the ability to bind to the ifenprodil-binding site of the NMDA receptor and to occupy the peripheral anionic site of acetylcholinesterase (AChE), which indicates that these compounds can act as blockers of AChE-induced beta-amyloid aggregation. Memantine 79-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 319-323 34498969-0 2021 Acetylcholinesterase and butyrylcholinesterase inhibition by nectriapyrone and tryptophol isolated from endophytic fungus Phomopsis sp. NECTRIAPYRONE 61-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 34498969-0 2021 Acetylcholinesterase and butyrylcholinesterase inhibition by nectriapyrone and tryptophol isolated from endophytic fungus Phomopsis sp. tryptophol 79-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 34541552-0 2021 Room temperature crystallography of human acetylcholinesterase bound to a substrate analogue 4K-TMA: Towards a neutron structure. 4k-tma 93-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 34541552-1 2021 Acetylcholinesterase (AChE) catalyzes hydrolysis of acetylcholine thereby terminating cholinergic nerve impulses for efficient neurotransmission. Acetylcholine 52-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 34541552-1 2021 Acetylcholinesterase (AChE) catalyzes hydrolysis of acetylcholine thereby terminating cholinergic nerve impulses for efficient neurotransmission. Acetylcholine 52-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 34541552-2 2021 Human AChE (hAChE) is a target of nerve agent and pesticide organophosphorus compounds that covalently attach to the catalytic Ser203 residue. organophosphorus 60-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 34541552-2 2021 Human AChE (hAChE) is a target of nerve agent and pesticide organophosphorus compounds that covalently attach to the catalytic Ser203 residue. organophosphorus 60-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-17 34541552-3 2021 Reactivation of inhibited hAChE can be achieved with nucleophilic antidotes, such as oximes. Oximes 85-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-31 34541552-5 2021 Here we report X-ray structures of hAChE conjugated with a reversible covalent inhibitor 4K-TMA (4K-TMA:hAChE) at 2.8 A resolution and of 4K-TMA:hAChE conjugate with oxime reactivator methoxime, MMB4 (4K-TMA:hAChE:MMB4) at 2.6 A resolution, both at physiologically relevant room temperature, as well as cryo-crystallographic structure of 4K-TMA:hAChE at 2.4 A resolution. 4,4-dimethylcholesta-8,14-dien-3-ol 92-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-40 34541552-5 2021 Here we report X-ray structures of hAChE conjugated with a reversible covalent inhibitor 4K-TMA (4K-TMA:hAChE) at 2.8 A resolution and of 4K-TMA:hAChE conjugate with oxime reactivator methoxime, MMB4 (4K-TMA:hAChE:MMB4) at 2.6 A resolution, both at physiologically relevant room temperature, as well as cryo-crystallographic structure of 4K-TMA:hAChE at 2.4 A resolution. 4,4-dimethylcholesta-8,14-dien-3-ol 100-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-40 34541552-5 2021 Here we report X-ray structures of hAChE conjugated with a reversible covalent inhibitor 4K-TMA (4K-TMA:hAChE) at 2.8 A resolution and of 4K-TMA:hAChE conjugate with oxime reactivator methoxime, MMB4 (4K-TMA:hAChE:MMB4) at 2.6 A resolution, both at physiologically relevant room temperature, as well as cryo-crystallographic structure of 4K-TMA:hAChE at 2.4 A resolution. 4,4-dimethylcholesta-8,14-dien-3-ol 141-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-150 34541552-5 2021 Here we report X-ray structures of hAChE conjugated with a reversible covalent inhibitor 4K-TMA (4K-TMA:hAChE) at 2.8 A resolution and of 4K-TMA:hAChE conjugate with oxime reactivator methoxime, MMB4 (4K-TMA:hAChE:MMB4) at 2.6 A resolution, both at physiologically relevant room temperature, as well as cryo-crystallographic structure of 4K-TMA:hAChE at 2.4 A resolution. Oximes 166-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-150 34541552-5 2021 Here we report X-ray structures of hAChE conjugated with a reversible covalent inhibitor 4K-TMA (4K-TMA:hAChE) at 2.8 A resolution and of 4K-TMA:hAChE conjugate with oxime reactivator methoxime, MMB4 (4K-TMA:hAChE:MMB4) at 2.6 A resolution, both at physiologically relevant room temperature, as well as cryo-crystallographic structure of 4K-TMA:hAChE at 2.4 A resolution. N,N'-monomethylenebis(pyridiniumaldoxime) 184-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-150 34541552-5 2021 Here we report X-ray structures of hAChE conjugated with a reversible covalent inhibitor 4K-TMA (4K-TMA:hAChE) at 2.8 A resolution and of 4K-TMA:hAChE conjugate with oxime reactivator methoxime, MMB4 (4K-TMA:hAChE:MMB4) at 2.6 A resolution, both at physiologically relevant room temperature, as well as cryo-crystallographic structure of 4K-TMA:hAChE at 2.4 A resolution. 4,4-dimethylcholesta-8,14-dien-3-ol 204-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-40 34541552-6 2021 4K-TMA acts as a substrate analogue reacting with the hydroxyl of Ser203 and generating a reversible tetrahedral hemiketal intermediate that closely resembles the first tetrahedral intermediate state during hAChE-catalyzed acetylcholine hydrolysis. 4,4-dimethylcholesta-8,14-dien-3-ol 3-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-212 34541552-6 2021 4K-TMA acts as a substrate analogue reacting with the hydroxyl of Ser203 and generating a reversible tetrahedral hemiketal intermediate that closely resembles the first tetrahedral intermediate state during hAChE-catalyzed acetylcholine hydrolysis. Acetylcholine 223-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-212 34541552-7 2021 Structural comparisons of room temperature with cryo-crystallographic structures of 4K-TMA:hAChE and published mAChE complexes with 4K-TMA, as well as the effect of MMB4 binding to the peripheral anionic site (PAS) of the 4K-TMA:hAChE complex, revealed only discrete, minor differences. 4,4-dimethylcholesta-8,14-dien-3-ol 135-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-96 34541552-8 2021 The active center geometry of AChE, already highly evolved for the efficient catalysis, was thus indicative of only minor conformational adjustments to accommodate the tetrahedral intermediate in the hydrolysis of the neurotransmitter acetylcholine (ACh). Acetylcholine 235-248 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 34541552-8 2021 The active center geometry of AChE, already highly evolved for the efficient catalysis, was thus indicative of only minor conformational adjustments to accommodate the tetrahedral intermediate in the hydrolysis of the neurotransmitter acetylcholine (ACh). Acetylcholine 250-253 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 34541552-9 2021 To map protonation states in the hAChE active site gorge we collected 3.5 A neutron diffraction data paving the way for obtaining higher resolution datasets that will be needed to determine locations of individual hydrogen atoms. Hydrogen 214-222 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-38 34502472-3 2021 Huprine-derived molecules have a high affinity towards the enzyme acetylcholinesterase (AChE), act as potent Abeta(1-42) peptide aggregation inhibitors, and improve the behavior of experimental animals. huprine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 34502472-3 2021 Huprine-derived molecules have a high affinity towards the enzyme acetylcholinesterase (AChE), act as potent Abeta(1-42) peptide aggregation inhibitors, and improve the behavior of experimental animals. huprine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 34476614-3 2021 Acetylcholinesterase hydrolyzed acetylthiocholine to generate thiocholine that bound with Cu2+ strongly via S-Cu-S bond. Acetylthiocholine 32-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 34476614-3 2021 Acetylcholinesterase hydrolyzed acetylthiocholine to generate thiocholine that bound with Cu2+ strongly via S-Cu-S bond. Thiocholine 62-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 34476614-3 2021 Acetylcholinesterase hydrolyzed acetylthiocholine to generate thiocholine that bound with Cu2+ strongly via S-Cu-S bond. cupric ion 90-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 34476614-3 2021 Acetylcholinesterase hydrolyzed acetylthiocholine to generate thiocholine that bound with Cu2+ strongly via S-Cu-S bond. Copper 110-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 34476614-3 2021 Acetylcholinesterase hydrolyzed acetylthiocholine to generate thiocholine that bound with Cu2+ strongly via S-Cu-S bond. Sulfur 113-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 34476614-4 2021 Dichlorvos as competitive inhibitor for acetylcholinesterase prevented the generation of thiocholine, which blocked the formation of Cu-thiocholine complex and changed the ratiometric fluorescence signal. Dichlorvos 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 34476614-4 2021 Dichlorvos as competitive inhibitor for acetylcholinesterase prevented the generation of thiocholine, which blocked the formation of Cu-thiocholine complex and changed the ratiometric fluorescence signal. Thiocholine 89-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 34476614-4 2021 Dichlorvos as competitive inhibitor for acetylcholinesterase prevented the generation of thiocholine, which blocked the formation of Cu-thiocholine complex and changed the ratiometric fluorescence signal. cu-thiocholine 133-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 34549134-1 2021 Palladium/BuAd2P efficiently catalyzed the direct alpha-arylation of ketone in the anti-Alzheimer"s disease drug donepezil, leading to 15 aryldonepezil analogues exhibiting high selective inhibition of acetylcholinesterase (AChE). Ketones 69-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-222 34549134-1 2021 Palladium/BuAd2P efficiently catalyzed the direct alpha-arylation of ketone in the anti-Alzheimer"s disease drug donepezil, leading to 15 aryldonepezil analogues exhibiting high selective inhibition of acetylcholinesterase (AChE). Ketones 69-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 224-228 34549134-1 2021 Palladium/BuAd2P efficiently catalyzed the direct alpha-arylation of ketone in the anti-Alzheimer"s disease drug donepezil, leading to 15 aryldonepezil analogues exhibiting high selective inhibition of acetylcholinesterase (AChE). Donepezil 113-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-222 34549134-1 2021 Palladium/BuAd2P efficiently catalyzed the direct alpha-arylation of ketone in the anti-Alzheimer"s disease drug donepezil, leading to 15 aryldonepezil analogues exhibiting high selective inhibition of acetylcholinesterase (AChE). Donepezil 113-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 224-228 34549134-1 2021 Palladium/BuAd2P efficiently catalyzed the direct alpha-arylation of ketone in the anti-Alzheimer"s disease drug donepezil, leading to 15 aryldonepezil analogues exhibiting high selective inhibition of acetylcholinesterase (AChE). aryldonepezil 138-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-222 34549134-1 2021 Palladium/BuAd2P efficiently catalyzed the direct alpha-arylation of ketone in the anti-Alzheimer"s disease drug donepezil, leading to 15 aryldonepezil analogues exhibiting high selective inhibition of acetylcholinesterase (AChE). aryldonepezil 138-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 224-228 34252860-4 2021 The best 3D-QSAR acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors pharmacophore hypotheses Hypo1 A and Hypo1 B were generated and validated by HypoGen program in Discovery Studio 2016 based on the training set of flavonoids, and then they were used as 3D query for screening the ZINC database. Flavonoids 236-246 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 34252860-7 2021 The result of best compound ZINC08751495 with AChE estimate activity (0.028), BChE estimate activity (1.55), AChE fit value (9.369), BChE fit value (8.415), AChE -CDOCKER ENERGY (30.22), BChE -CDOCKER ENERGY (33.13) has the potential for further development as a supplement to treat Alzheimer"s disease. zinc08751495 28-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 34252860-7 2021 The result of best compound ZINC08751495 with AChE estimate activity (0.028), BChE estimate activity (1.55), AChE fit value (9.369), BChE fit value (8.415), AChE -CDOCKER ENERGY (30.22), BChE -CDOCKER ENERGY (33.13) has the potential for further development as a supplement to treat Alzheimer"s disease. zinc08751495 28-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 34252860-7 2021 The result of best compound ZINC08751495 with AChE estimate activity (0.028), BChE estimate activity (1.55), AChE fit value (9.369), BChE fit value (8.415), AChE -CDOCKER ENERGY (30.22), BChE -CDOCKER ENERGY (33.13) has the potential for further development as a supplement to treat Alzheimer"s disease. zinc08751495 28-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 34304133-1 2021 A series of novel 2-hydroxybenzylamine-deoxyvasicinone hybrid analogs (8a-8n) have been synthesized and evaluated as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), and as inhibitors of amyloid peptide (Abeta1-42) aggregation, for treatment of Alzheimer"s disease (AD). 2-(aminomethyl)phenol 18-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-151 34304133-1 2021 A series of novel 2-hydroxybenzylamine-deoxyvasicinone hybrid analogs (8a-8n) have been synthesized and evaluated as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), and as inhibitors of amyloid peptide (Abeta1-42) aggregation, for treatment of Alzheimer"s disease (AD). 2-(aminomethyl)phenol 18-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 34304133-1 2021 A series of novel 2-hydroxybenzylamine-deoxyvasicinone hybrid analogs (8a-8n) have been synthesized and evaluated as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), and as inhibitors of amyloid peptide (Abeta1-42) aggregation, for treatment of Alzheimer"s disease (AD). 2,3-trimethylene-4-quinazolone 39-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-151 34304133-1 2021 A series of novel 2-hydroxybenzylamine-deoxyvasicinone hybrid analogs (8a-8n) have been synthesized and evaluated as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), and as inhibitors of amyloid peptide (Abeta1-42) aggregation, for treatment of Alzheimer"s disease (AD). 2,3-trimethylene-4-quinazolone 39-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 34304133-1 2021 A series of novel 2-hydroxybenzylamine-deoxyvasicinone hybrid analogs (8a-8n) have been synthesized and evaluated as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), and as inhibitors of amyloid peptide (Abeta1-42) aggregation, for treatment of Alzheimer"s disease (AD). 8a-8n 71-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-151 34304133-1 2021 A series of novel 2-hydroxybenzylamine-deoxyvasicinone hybrid analogs (8a-8n) have been synthesized and evaluated as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), and as inhibitors of amyloid peptide (Abeta1-42) aggregation, for treatment of Alzheimer"s disease (AD). 8a-8n 71-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 34304133-3 2021 Analogs8g and 8n were found to be the most potent AChE inhibitors in the series with IC50values of 0.38 microM and 0.34 microM, respectively. g and 8-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 34139326-6 2021 Moreover, lysergic acid structure encompasses the general structural requirements for acetylcholinesterase inhibition. Lysergic Acid 10-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 34265256-1 2021 Current organophosphate (OP) toxicity research now considers potential non-cholinergic mechanisms for these compounds, since the inhibition of acetylcholinesterase (AChE) cannot completely explain all the adverse biological effects of OP. Organophosphates 8-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 34324828-0 2021 Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects. Organophosphates 32-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-28 34324828-1 2021 Acetylcholinesterase (EC 3.1.1.7; AChE), a key acetylcholine-hydrolyzing enzyme in cholinergic neurotransmission, is present in a variety of states in situ, including monomers, C-terminally disulfide-linked homodimers, homotetramers, and up to three tetramers covalently attached to structural subunits. Acetylcholine 47-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 34324828-1 2021 Acetylcholinesterase (EC 3.1.1.7; AChE), a key acetylcholine-hydrolyzing enzyme in cholinergic neurotransmission, is present in a variety of states in situ, including monomers, C-terminally disulfide-linked homodimers, homotetramers, and up to three tetramers covalently attached to structural subunits. Acetylcholine 47-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 34324828-1 2021 Acetylcholinesterase (EC 3.1.1.7; AChE), a key acetylcholine-hydrolyzing enzyme in cholinergic neurotransmission, is present in a variety of states in situ, including monomers, C-terminally disulfide-linked homodimers, homotetramers, and up to three tetramers covalently attached to structural subunits. Disulfides 190-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 34324828-5 2021 We also demonstrate the dissociation of organophosphate (OP)-conjugated dimers is reversed by structurally diverse oximes 2PAM, HI6 or RS194B, as demonstrated by SAXS of diethylphosphoryl-hAChE. Organophosphates 40-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-193 34324828-5 2021 We also demonstrate the dissociation of organophosphate (OP)-conjugated dimers is reversed by structurally diverse oximes 2PAM, HI6 or RS194B, as demonstrated by SAXS of diethylphosphoryl-hAChE. Oximes 115-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-193 34324828-5 2021 We also demonstrate the dissociation of organophosphate (OP)-conjugated dimers is reversed by structurally diverse oximes 2PAM, HI6 or RS194B, as demonstrated by SAXS of diethylphosphoryl-hAChE. diethylphosphoryl 170-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-193 34324828-6 2021 However, binding of oximes to the native ligand-free hAChE, binding of high-affinity reversible ligands, or formation of a SP-sarin-hAChE conjugate had no effect on homodimerization. Oximes 20-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-58 34500749-2 2021 Two of these substituted 3-nitro-6-amino-imidazo(1,2-b)pyridazine compounds (5c and 5h) showed potent acetylcholinesterase (AChE) inhibitory activity (IC50 40-50 nM), which we have previously reported. 3-nitro-6-amino-imidazo(1,2-b)pyridazine 25-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 34500749-2 2021 Two of these substituted 3-nitro-6-amino-imidazo(1,2-b)pyridazine compounds (5c and 5h) showed potent acetylcholinesterase (AChE) inhibitory activity (IC50 40-50 nM), which we have previously reported. 5h 84-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 34500749-9 2021 These results suggested that the substituted imidazo (1,2-b) pyridazine compounds, which have potent AChE inhibitory activity, were also capable of antiproliferative, anti-migratory, and anti-inflammatory effects at higher doses. imidazo (1,2-b) pyridazine 45-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 34836871-4 2021 Two compounds of the series 1g and 1h were found to be active against AChE whereas no derivative was active against BChE while the whole series showed excellent 1, 1-diphenyl-2-picrylhydrazyl scavenging activity. Hydrogen 35-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 34216669-0 2021 In silico, theoretical biointerface analysis and in vitro kinetic analysis of amine compounds interaction with acetylcholinesterase and butyrylcholinesterase. Amines 78-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 34216669-6 2021 Binding energy calculated through MMGBSA method identified the non-covalent interactions (electrostatic and Van der Waals interactions) have contributed to the stable binding of the amine compounds with the AChE/BChE. Amines 182-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-211 34216669-7 2021 Biointerface between amine compounds and AChE/BChE were visualized through Hirshfeld surface analysis. Amines 21-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 34445873-3 2021 Most of the N-aryl-huperzine A (N-aryl-HPA) analogues showed good acetylcholinesterase (AChE) inhibitory activity in in vitro experiments. n-aryl-huperzine 12-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 34445873-4 2021 Three arylated huperzine A analogues (14, 19, and 30) exhibited stronger anti-AChE activity than HPA. arylated 6-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 34445873-4 2021 Three arylated huperzine A analogues (14, 19, and 30) exhibited stronger anti-AChE activity than HPA. huperzine A 15-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 34445873-5 2021 The 5-methoxy-2-pyridyl analogue (30) displayed the most potent AChE inhibition activity, with an IC50 value of 1.5 muM, which was 7.6-fold more active than HPA. 5-methoxy-2-pyridyl 4-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 34512307-7 2021 The activity and protein levels of ChAT and acetylcholinesterase (AChE), the enzyme catalyzing the hydrolysis of ACh, were analyzed using an integrated activity and protein concentration ELISA-like assay. Acetylcholine 113-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 34512307-7 2021 The activity and protein levels of ChAT and acetylcholinesterase (AChE), the enzyme catalyzing the hydrolysis of ACh, were analyzed using an integrated activity and protein concentration ELISA-like assay. Acetylcholine 113-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 34558680-2 2022 Here, we describe synthesis, photochemical properties, and biochemical activities of two caged oxime compounds applied in the photocontrolled reactivation of the AChE inactivated by reactive organophosphate. Oximes 95-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-166 34558680-2 2022 Here, we describe synthesis, photochemical properties, and biochemical activities of two caged oxime compounds applied in the photocontrolled reactivation of the AChE inactivated by reactive organophosphate. Organophosphates 191-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-166 34558680-3 2022 Each of these consists of a photocleavable coumarin cage tethered to a known oxime reactivator for AChE that belongs in an either 2-(hydroxyimino)acetamide or pyridiniumaldoxime class. coumarin 43-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 34558680-3 2022 Each of these consists of a photocleavable coumarin cage tethered to a known oxime reactivator for AChE that belongs in an either 2-(hydroxyimino)acetamide or pyridiniumaldoxime class. Oximes 77-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 34558680-3 2022 Each of these consists of a photocleavable coumarin cage tethered to a known oxime reactivator for AChE that belongs in an either 2-(hydroxyimino)acetamide or pyridiniumaldoxime class. 2-(hydroxyimino)acetamide 130-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 34558680-3 2022 Each of these consists of a photocleavable coumarin cage tethered to a known oxime reactivator for AChE that belongs in an either 2-(hydroxyimino)acetamide or pyridiniumaldoxime class. pyridiniumaldoxime 159-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 34404888-4 2021 This was a prospective study of 57 patients undergoing ambulatory or vascular surgery under GA. Cholinesterase activity was measured before the induction of anesthesia, after 15 min and at the end of surgery by calculating the capacity of serum acetylcholinesterase (AChE) and butyrylcholinesterase to hydrolyze AcetylThioCholine. Acetylthiocholine 312-329 acetylcholinesterase (Cartwright blood group) Homo sapiens 245-265 34522196-0 2021 Design, synthesis, and bio-evaluation of new isoindoline-1,3-dione derivatives as possible inhibitors of acetylcholinesterase. isoindoline-1,3-dione 45-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 34522196-2 2021 A significant decrease in acetylcholine level in the brain is common in most patients with Alzheimer"s disease, therefore acetylcholinesterase (AChE) inhibitors such as donepezil and rivastigmine are widely used for patients with limited therapeutic results and major side effects. Acetylcholine 26-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 34522196-2 2021 A significant decrease in acetylcholine level in the brain is common in most patients with Alzheimer"s disease, therefore acetylcholinesterase (AChE) inhibitors such as donepezil and rivastigmine are widely used for patients with limited therapeutic results and major side effects. Acetylcholine 26-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 34522196-2 2021 A significant decrease in acetylcholine level in the brain is common in most patients with Alzheimer"s disease, therefore acetylcholinesterase (AChE) inhibitors such as donepezil and rivastigmine are widely used for patients with limited therapeutic results and major side effects. Donepezil 169-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 34522196-2 2021 A significant decrease in acetylcholine level in the brain is common in most patients with Alzheimer"s disease, therefore acetylcholinesterase (AChE) inhibitors such as donepezil and rivastigmine are widely used for patients with limited therapeutic results and major side effects. Donepezil 169-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 34522196-2 2021 A significant decrease in acetylcholine level in the brain is common in most patients with Alzheimer"s disease, therefore acetylcholinesterase (AChE) inhibitors such as donepezil and rivastigmine are widely used for patients with limited therapeutic results and major side effects. Rivastigmine 183-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 34522196-2 2021 A significant decrease in acetylcholine level in the brain is common in most patients with Alzheimer"s disease, therefore acetylcholinesterase (AChE) inhibitors such as donepezil and rivastigmine are widely used for patients with limited therapeutic results and major side effects. Rivastigmine 183-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 34522196-10 2021 Conclusion and implications: The synthesized compounds demonstrated moderate to good AChE inhibitory effect with results higher than rivastigmine. Rivastigmine 133-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 34404888-8 2021 Patients requiring intraoperative administration of phenylephrine for hemodynamic support (21.1%) had a significantly lower level of AChE and CS compared to untreated patients. Phenylephrine 52-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 34443482-7 2021 In silico study suggested the compounds preferred the peripheral anionic site (PAS) to the catalytic anionic site (CAS), which was different from AChE inhibitors (tacrine and galanthamine). Galantamine 175-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 34671741-0 2021 Dual acting oximes designed for therapeutic decontamination of reactive organophosphates via catalytic inactivation and acetylcholinesterase reactivation. Oximes 12-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 34671741-5 2021 This library was screened by enzyme assays performed with human and electric eel subtypes of OP-inactivated AChE, which led to identifying three oxime leads that displayed significant enhancements in reactivation activity comparable to 2-PAM. Oximes 145-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 34348147-2 2021 Cholinergic agonists and acetylcholinesterase inhibitors can enhance cognitive functioning, as does intermittent electrical stimulation of the cortical source of acetylcholine, the nucleus basalis (NB) of Meynert. Acetylcholine 162-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 34080709-0 2021 Synthesis and biological evaluation of some 1-naphthol derivatives as antioxidants, acetylcholinesterase, and carbonic anhydrase inhibitors. 1-naphthol 44-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 34080709-9 2021 These 1-naphthol derivatives were found as effective inhibitors for hCA I, hCA II, and AChE with Ki values ranging from 0.034 +- 0.54 to 0.724 +- 0.18 microM for hCA I, 0.172 +- 0.02 to 0.562 +- 0.21 microM for hCA II, and 0.096 +- 0.01 to 0.177 +- 0.02 microM for AChE. 1-naphthol 6-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 34080709-9 2021 These 1-naphthol derivatives were found as effective inhibitors for hCA I, hCA II, and AChE with Ki values ranging from 0.034 +- 0.54 to 0.724 +- 0.18 microM for hCA I, 0.172 +- 0.02 to 0.562 +- 0.21 microM for hCA II, and 0.096 +- 0.01 to 0.177 +- 0.02 microM for AChE. 1-naphthol 6-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 265-269 34319331-1 2021 Malathion is a commercially available insecticide that functions by acting as an acetylcholinesterase inhibitor. Malathion 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 34060234-4 2021 Virtual screening followed by the evaluation of AChE inhibitory activity allowed us to identify 1,2,4-triazolylthioethanones as a novel class of AChE inhibitors. 1,2,4-triazolylthioethanones 96-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 34060234-4 2021 Virtual screening followed by the evaluation of AChE inhibitory activity allowed us to identify 1,2,4-triazolylthioethanones as a novel class of AChE inhibitors. 1,2,4-triazolylthioethanones 96-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 34132933-2 2021 The enzyme acetylcholinesterase (AChE) cleaves the ester bonds in acetylcholine and plays an important role in the termination of acetylcholine activity at cholinergic synapses in various regions of the nervous system. Esters 51-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 34132933-2 2021 The enzyme acetylcholinesterase (AChE) cleaves the ester bonds in acetylcholine and plays an important role in the termination of acetylcholine activity at cholinergic synapses in various regions of the nervous system. Esters 51-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 34132933-2 2021 The enzyme acetylcholinesterase (AChE) cleaves the ester bonds in acetylcholine and plays an important role in the termination of acetylcholine activity at cholinergic synapses in various regions of the nervous system. Acetylcholine 66-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 34132933-2 2021 The enzyme acetylcholinesterase (AChE) cleaves the ester bonds in acetylcholine and plays an important role in the termination of acetylcholine activity at cholinergic synapses in various regions of the nervous system. Acetylcholine 66-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 34132933-2 2021 The enzyme acetylcholinesterase (AChE) cleaves the ester bonds in acetylcholine and plays an important role in the termination of acetylcholine activity at cholinergic synapses in various regions of the nervous system. Acetylcholine 130-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 34132933-2 2021 The enzyme acetylcholinesterase (AChE) cleaves the ester bonds in acetylcholine and plays an important role in the termination of acetylcholine activity at cholinergic synapses in various regions of the nervous system. Acetylcholine 130-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 34132933-8 2021 Separately, the crystal structure of AChE in complex with (-)-galantamine was used to perform molecular docking calculations with the entire SistematX dataset. Galantamine 62-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 34132933-11 2021 Finally, two sesquiterpene lactones, structures 15 and 24, were predicted to be able to cross the blood-brain barrier, which was confirmed in the VolSurf+ quantitative model, revealing these two structures as the most promising secondary metabolites for AChE inhibition among the 8593 molecules tested. sesquiterpene lactones 13-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 254-258 34170111-7 2021 As a proof-of-concept application, the free-standing POD-like membranes were applied as a label-free assay in sensing cysteine, as well as monitoring acetylcholinesterase (AChE) activity through the generated thiol-containing product. Sulfhydryl Compounds 209-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 34443482-7 2021 In silico study suggested the compounds preferred the peripheral anionic site (PAS) to the catalytic anionic site (CAS), which was different from AChE inhibitors (tacrine and galanthamine). Tacrine 163-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 34330964-2 2021 The current standard treatment against their effects relies on the use of small molecule-based oximes that can efficiently restore acetylcholinesterase (AChE) activity. Oximes 95-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-151 34330964-2 2021 The current standard treatment against their effects relies on the use of small molecule-based oximes that can efficiently restore acetylcholinesterase (AChE) activity. Oximes 95-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 34330964-3 2021 Despite their efficacy in reactivating AChE, the action of drugs like 2-pralidoxime (2-PAM) is primarily limited to the peripheral nervous system (PNS) and, thus, provides no significant protection to the central nervous system (CNS). 2-pralidoxime 70-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 34330964-3 2021 Despite their efficacy in reactivating AChE, the action of drugs like 2-pralidoxime (2-PAM) is primarily limited to the peripheral nervous system (PNS) and, thus, provides no significant protection to the central nervous system (CNS). Pralidoxime Compounds 85-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 34360916-6 2021 Finally, we demonstrate that these enzymes can degrade ethyl-paraoxon down to sub-inhibitory concentrations of acetylcholinesterase, confirming their efficacy from high to micromolar doses. ethylparaoxon 55-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 34256363-0 2021 A highly sensitive acetylcholinesterase electrochemical biosensor based on Au-Tb alloy nanospheres for determining organophosphate pesticides. au-tb alloy 75-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 34256363-0 2021 A highly sensitive acetylcholinesterase electrochemical biosensor based on Au-Tb alloy nanospheres for determining organophosphate pesticides. Organophosphates 115-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 34256363-2 2021 In this study, we developed a novel acetylcholinesterase (AChE) biosensor based on Au-Tb alloy nanospheres (NSs) for rapid and sensitive detection of OPs for the first time. Gold 83-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 34256363-2 2021 In this study, we developed a novel acetylcholinesterase (AChE) biosensor based on Au-Tb alloy nanospheres (NSs) for rapid and sensitive detection of OPs for the first time. Gold 83-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 34256363-2 2021 In this study, we developed a novel acetylcholinesterase (AChE) biosensor based on Au-Tb alloy nanospheres (NSs) for rapid and sensitive detection of OPs for the first time. Terbium 86-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 34256363-2 2021 In this study, we developed a novel acetylcholinesterase (AChE) biosensor based on Au-Tb alloy nanospheres (NSs) for rapid and sensitive detection of OPs for the first time. Terbium 86-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 34256363-4 2021 Under optimal conditions, the AChE biosensor was obtained by a simple assembly process, with a big linear range (10-13 M - 10-7 M) and the limit of detection was 2.51 x 10-14 M for the determination of methyl parathion. Methyl Parathion 202-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 34327619-1 2021 Multi-target directed ligand-based 2D-QSAR models were developed using different N-benzyl piperidine derivatives showing inhibitory activity toward acetylcholinesterase (AChE) and beta-Site amyloid precursor protein cleaving enzyme (BACE1). 1-benzylpiperidine 81-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-168 34327619-1 2021 Multi-target directed ligand-based 2D-QSAR models were developed using different N-benzyl piperidine derivatives showing inhibitory activity toward acetylcholinesterase (AChE) and beta-Site amyloid precursor protein cleaving enzyme (BACE1). 1-benzylpiperidine 81-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 34361702-2 2021 Over the last decade, many innovative curcumin-based compounds have been designed and synthesized, searching for new derivatives having anti-amyloidogenic, inhibitory of tau formation, as well as anti-neuroinflammation, antioxidative, and AChE inhibitory activities. Curcumin 38-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 239-243 34361702-4 2021 Most of the 3-(7-phenyl-3,5-dioxohepta-1,6-dien-1-yl)coumarin derivatives 11-18 resulted in moderated inhibitors of hMAO isoforms and AChE and BuChE activity. 3-(7-phenyl-3,5-dioxohepta-1,6-dien-1-yl) 12-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 34361702-4 2021 Most of the 3-(7-phenyl-3,5-dioxohepta-1,6-dien-1-yl)coumarin derivatives 11-18 resulted in moderated inhibitors of hMAO isoforms and AChE and BuChE activity. coumarin 53-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 34299650-4 2021 Magnoflorine was shown to be a selective inhibitor of human butyrylcholinesterase-hBChE (IC50 = 131 +- 9 muM and IC50 = 1120 +- 83 muM, for hBuChE and human acetylcholinesterase-hAChE, respectively), while nitidine showed comparable inhibitory potencies against both enzymes (IC50 = 6.68 +- 0.13 muM and IC50 = 5.31 +- 0.50 muM, for hBChE and hAChE, respectively). magnoflorine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-183 34299650-4 2021 Magnoflorine was shown to be a selective inhibitor of human butyrylcholinesterase-hBChE (IC50 = 131 +- 9 muM and IC50 = 1120 +- 83 muM, for hBuChE and human acetylcholinesterase-hAChE, respectively), while nitidine showed comparable inhibitory potencies against both enzymes (IC50 = 6.68 +- 0.13 muM and IC50 = 5.31 +- 0.50 muM, for hBChE and hAChE, respectively). magnoflorine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 343-348 34299650-5 2021 When compared with the commercial anti-Alzheimer drug galanthamine, nitidine was as potent as galanthamine against hAChE and one order of magnitude more potent against hBuChE. nitidine 68-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-120 34299650-5 2021 When compared with the commercial anti-Alzheimer drug galanthamine, nitidine was as potent as galanthamine against hAChE and one order of magnitude more potent against hBuChE. Galantamine 94-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-120 34337258-3 2021 Compounds 13, 17, 18, 21, 23, 31, and 33 displayed moderate activity with 25-50% relative potency compared to the known potent AChE inhibitor donepezil. Donepezil 142-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 34337258-4 2021 Molecular docking studies of the active compounds docked within the active site cavity of AChE showed a binding orientation similar to that of donepezil, with good predicted binding affinities. Donepezil 143-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 34299238-9 2021 The ethyl acetate extracts substantially depressed cholinesterase enzymes (4.49 and 12.26 mg galantamine equivalent/g extract against AChE and BChE, respectively) and alpha-amylase enzyme (1.04 mmol acarbose equivalent/g extract). ethyl acetate 4-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 34964956-6 2021 The dihydro-pyrrole alkaloid tiliine A, the piperidine alkaloid tiliamine B, and the acetylated piperidine alkaloid tilacetine A were characterized as acetylcholinesterase inhibitors. pyrroline 4-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-171 34964956-6 2021 The dihydro-pyrrole alkaloid tiliine A, the piperidine alkaloid tiliamine B, and the acetylated piperidine alkaloid tilacetine A were characterized as acetylcholinesterase inhibitors. tiliine a 29-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-171 34964956-6 2021 The dihydro-pyrrole alkaloid tiliine A, the piperidine alkaloid tiliamine B, and the acetylated piperidine alkaloid tilacetine A were characterized as acetylcholinesterase inhibitors. piperidine 44-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-171 34964956-6 2021 The dihydro-pyrrole alkaloid tiliine A, the piperidine alkaloid tiliamine B, and the acetylated piperidine alkaloid tilacetine A were characterized as acetylcholinesterase inhibitors. tiliamine b 64-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-171 34964956-6 2021 The dihydro-pyrrole alkaloid tiliine A, the piperidine alkaloid tiliamine B, and the acetylated piperidine alkaloid tilacetine A were characterized as acetylcholinesterase inhibitors. tilacetine 116-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-171 34170111-7 2021 As a proof-of-concept application, the free-standing POD-like membranes were applied as a label-free assay in sensing cysteine, as well as monitoring acetylcholinesterase (AChE) activity through the generated thiol-containing product. Sulfhydryl Compounds 209-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-176 34170111-8 2021 Furthermore, based on the toxicity effect of organophosphorus (OP) compounds on AChE, the robust membranes were successfully utilized to evaluate the toxicity of diverse OP compounds. organophosphorus 45-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 34160494-3 2021 Then, AChE was immobilized on CdS/ZnO/ITO with chitosan to obtain an AChE/CdS/ZnO EGFET sensor. Chitosan 47-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 34160494-3 2021 Then, AChE was immobilized on CdS/ZnO/ITO with chitosan to obtain an AChE/CdS/ZnO EGFET sensor. Zinc Oxide 78-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 34160494-3 2021 Then, AChE was immobilized on CdS/ZnO/ITO with chitosan to obtain an AChE/CdS/ZnO EGFET sensor. Zinc Oxide 78-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 34160494-6 2021 The results show that the AChE/CdS/ZnO EGFET sensor has extremely high sensitivity and good selectivity. Zinc Oxide 35-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 34395382-4 2021 Furthermore, based on this catalytic reaction, taken together with the two enzymatic catalytic systems of acetylcholinesterase (AChE) and choline oxidase (CHO), a highly sensitive multi-catalytic sensing system could be successfully developed for organophosphorus (OPs) pesticides such as dimethoate, DDVP, and parathion-methyl. Choline 138-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 34395382-4 2021 Furthermore, based on this catalytic reaction, taken together with the two enzymatic catalytic systems of acetylcholinesterase (AChE) and choline oxidase (CHO), a highly sensitive multi-catalytic sensing system could be successfully developed for organophosphorus (OPs) pesticides such as dimethoate, DDVP, and parathion-methyl. organophosphorus 247-263 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 34395382-4 2021 Furthermore, based on this catalytic reaction, taken together with the two enzymatic catalytic systems of acetylcholinesterase (AChE) and choline oxidase (CHO), a highly sensitive multi-catalytic sensing system could be successfully developed for organophosphorus (OPs) pesticides such as dimethoate, DDVP, and parathion-methyl. organophosphorus 247-263 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 34395382-4 2021 Furthermore, based on this catalytic reaction, taken together with the two enzymatic catalytic systems of acetylcholinesterase (AChE) and choline oxidase (CHO), a highly sensitive multi-catalytic sensing system could be successfully developed for organophosphorus (OPs) pesticides such as dimethoate, DDVP, and parathion-methyl. OPS 265-268 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 34395382-4 2021 Furthermore, based on this catalytic reaction, taken together with the two enzymatic catalytic systems of acetylcholinesterase (AChE) and choline oxidase (CHO), a highly sensitive multi-catalytic sensing system could be successfully developed for organophosphorus (OPs) pesticides such as dimethoate, DDVP, and parathion-methyl. OPS 265-268 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 34395382-4 2021 Furthermore, based on this catalytic reaction, taken together with the two enzymatic catalytic systems of acetylcholinesterase (AChE) and choline oxidase (CHO), a highly sensitive multi-catalytic sensing system could be successfully developed for organophosphorus (OPs) pesticides such as dimethoate, DDVP, and parathion-methyl. Dimethoate 289-299 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 34395382-4 2021 Furthermore, based on this catalytic reaction, taken together with the two enzymatic catalytic systems of acetylcholinesterase (AChE) and choline oxidase (CHO), a highly sensitive multi-catalytic sensing system could be successfully developed for organophosphorus (OPs) pesticides such as dimethoate, DDVP, and parathion-methyl. Dimethoate 289-299 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 34395382-4 2021 Furthermore, based on this catalytic reaction, taken together with the two enzymatic catalytic systems of acetylcholinesterase (AChE) and choline oxidase (CHO), a highly sensitive multi-catalytic sensing system could be successfully developed for organophosphorus (OPs) pesticides such as dimethoate, DDVP, and parathion-methyl. Dichlorvos 301-305 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 34395382-4 2021 Furthermore, based on this catalytic reaction, taken together with the two enzymatic catalytic systems of acetylcholinesterase (AChE) and choline oxidase (CHO), a highly sensitive multi-catalytic sensing system could be successfully developed for organophosphorus (OPs) pesticides such as dimethoate, DDVP, and parathion-methyl. Dichlorvos 301-305 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 34395382-4 2021 Furthermore, based on this catalytic reaction, taken together with the two enzymatic catalytic systems of acetylcholinesterase (AChE) and choline oxidase (CHO), a highly sensitive multi-catalytic sensing system could be successfully developed for organophosphorus (OPs) pesticides such as dimethoate, DDVP, and parathion-methyl. Methyl Parathion 311-327 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 34395382-4 2021 Furthermore, based on this catalytic reaction, taken together with the two enzymatic catalytic systems of acetylcholinesterase (AChE) and choline oxidase (CHO), a highly sensitive multi-catalytic sensing system could be successfully developed for organophosphorus (OPs) pesticides such as dimethoate, DDVP, and parathion-methyl. Methyl Parathion 311-327 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 34156230-3 2021 We have previously designed and synthesized dimeric tacrine(10)-hupyridone (A10E), a novel tacrine derivative with acetylcholinesterase (AChE) inhibition and brain-derived neurotrophic factor (BDNF) activation activity, by linking tacrine and a fragment of huperzine A. Tacrine 52-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 34156230-3 2021 We have previously designed and synthesized dimeric tacrine(10)-hupyridone (A10E), a novel tacrine derivative with acetylcholinesterase (AChE) inhibition and brain-derived neurotrophic factor (BDNF) activation activity, by linking tacrine and a fragment of huperzine A. Tacrine 52-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 34156230-3 2021 We have previously designed and synthesized dimeric tacrine(10)-hupyridone (A10E), a novel tacrine derivative with acetylcholinesterase (AChE) inhibition and brain-derived neurotrophic factor (BDNF) activation activity, by linking tacrine and a fragment of huperzine A. 5-amino-5,6,7,8-tetrahydroquinolin-2(1H)-one 64-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 34156230-3 2021 We have previously designed and synthesized dimeric tacrine(10)-hupyridone (A10E), a novel tacrine derivative with acetylcholinesterase (AChE) inhibition and brain-derived neurotrophic factor (BDNF) activation activity, by linking tacrine and a fragment of huperzine A. 5-amino-5,6,7,8-tetrahydroquinolin-2(1H)-one 64-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 34156230-3 2021 We have previously designed and synthesized dimeric tacrine(10)-hupyridone (A10E), a novel tacrine derivative with acetylcholinesterase (AChE) inhibition and brain-derived neurotrophic factor (BDNF) activation activity, by linking tacrine and a fragment of huperzine A. Tacrine 231-238 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 34156230-3 2021 We have previously designed and synthesized dimeric tacrine(10)-hupyridone (A10E), a novel tacrine derivative with acetylcholinesterase (AChE) inhibition and brain-derived neurotrophic factor (BDNF) activation activity, by linking tacrine and a fragment of huperzine A. huperzine A 257-268 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 34285627-3 2021 One of the causes leading to AD is the decrease of neurotransmitter acetylcholine (ACh) levels in the brain, in part due to a higher activity of acetylcholinesterase (AChE), the enzyme responsible for its degradation. Acetylcholine 68-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 34285627-3 2021 One of the causes leading to AD is the decrease of neurotransmitter acetylcholine (ACh) levels in the brain, in part due to a higher activity of acetylcholinesterase (AChE), the enzyme responsible for its degradation. Acetylcholine 68-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 34285627-3 2021 One of the causes leading to AD is the decrease of neurotransmitter acetylcholine (ACh) levels in the brain, in part due to a higher activity of acetylcholinesterase (AChE), the enzyme responsible for its degradation. Acetylcholine 83-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 34285627-3 2021 One of the causes leading to AD is the decrease of neurotransmitter acetylcholine (ACh) levels in the brain, in part due to a higher activity of acetylcholinesterase (AChE), the enzyme responsible for its degradation. Acetylcholine 83-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 34285627-8 2021 Moreover, rivastigmine is considered a pseudo-irreversible compound with anti-AChE action, providing similar effects at the clinical level. Rivastigmine 10-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 34203347-0 2021 1,3,5-Triazine Nitrogen Mustards with Different Peptide Group as Innovative Candidates for AChE and BACE1 Inhibitors. 1,3,5-TRIAZINE 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 34351546-4 2021 In vivo and in vitro evidence has revealed that bisphosphonic acids, containing hydrophobic systems, have a good selectivity of insect AChE inhibition. bisphosphonic acids 48-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 34203347-0 2021 1,3,5-Triazine Nitrogen Mustards with Different Peptide Group as Innovative Candidates for AChE and BACE1 Inhibitors. Nitrogen 15-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 34203347-1 2021 A series of new analogs of nitrogen mustards (4a-4h) containing the 1,3,5-triazine ring substituted with dipeptide residue were synthesized and evaluated for the inhibition of both acetylcholinesterase (AChE) and beta-secretase (BACE1) enzymes. Nitrogen 27-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-201 34203347-1 2021 A series of new analogs of nitrogen mustards (4a-4h) containing the 1,3,5-triazine ring substituted with dipeptide residue were synthesized and evaluated for the inhibition of both acetylcholinesterase (AChE) and beta-secretase (BACE1) enzymes. Nitrogen 27-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 203-207 34203347-1 2021 A series of new analogs of nitrogen mustards (4a-4h) containing the 1,3,5-triazine ring substituted with dipeptide residue were synthesized and evaluated for the inhibition of both acetylcholinesterase (AChE) and beta-secretase (BACE1) enzymes. 4a-4h 46-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-201 34203347-1 2021 A series of new analogs of nitrogen mustards (4a-4h) containing the 1,3,5-triazine ring substituted with dipeptide residue were synthesized and evaluated for the inhibition of both acetylcholinesterase (AChE) and beta-secretase (BACE1) enzymes. 4a-4h 46-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 203-207 34165688-5 2022 Tacrine was used as the reference drug and its IC50 values were 20.85 nM and 15.66 nM towards AChE and BuChE, respectively. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 34385858-0 2021 Integrated 3D-QSAR, molecular docking, and molecular dynamics simulation studies on 1,2,3-triazole based derivatives for designing new acetylcholinesterase inhibitors. Triazoles 84-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 34385858-3 2021 A dataset of twenty-six 1,2,3-triazole-based derivatives previously synthetized and evaluated for acetylcholinesterase inhibitory activity were subjected to the three-dimensional quantitative structure-activity relationship (3D-QSAR) study. Triazoles 24-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-118 34385868-0 2021 Novel Mannich bases with strong carbonic anhydrases and acetylcholinesterase inhibition effects: 3-(aminomethyl)-6-{3-(4-(trifluoromethyl)phenyl)acryloyl}-2(3H)-benzoxazolones. bases 14-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 34385868-0 2021 Novel Mannich bases with strong carbonic anhydrases and acetylcholinesterase inhibition effects: 3-(aminomethyl)-6-{3-(4-(trifluoromethyl)phenyl)acryloyl}-2(3H)-benzoxazolones. 3-(aminomethyl)-6-{3-(4-(trifluoromethyl)phenyl)acryloyl}-2(3h)-benzoxazolones 97-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 34385868-6 2021 Ki value of Tacrine (TAC), the reference compound, was 68.6 +- 3.8 nM towards AChE. Tacrine 12-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 34385868-6 2021 Ki value of Tacrine (TAC), the reference compound, was 68.6 +- 3.8 nM towards AChE. Tacrine 21-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 34188447-7 2021 Results: Importantly, the complex of AAZ8 exhibited more potent activity giving IC50 values of 14 microg/mL and 18microg/mL as AChE and BChE cholinesterase inhibitors, respectively, when compared with standard positive control galantamine. aaz8 37-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 34188447-9 2021 Conclusion: Herein, we report two new amide carboxylate zinc (II) complexes which were potentially analyzed for various biological applications like acetylcholinesterase (AChE), butyrylcholinesterase (BChE) inhibitory potentials, and antioxidant assays. amide carboxylate 38-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-169 34188447-9 2021 Conclusion: Herein, we report two new amide carboxylate zinc (II) complexes which were potentially analyzed for various biological applications like acetylcholinesterase (AChE), butyrylcholinesterase (BChE) inhibitory potentials, and antioxidant assays. amide carboxylate 38-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 34188447-9 2021 Conclusion: Herein, we report two new amide carboxylate zinc (II) complexes which were potentially analyzed for various biological applications like acetylcholinesterase (AChE), butyrylcholinesterase (BChE) inhibitory potentials, and antioxidant assays. Zinc 56-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-169 34188447-9 2021 Conclusion: Herein, we report two new amide carboxylate zinc (II) complexes which were potentially analyzed for various biological applications like acetylcholinesterase (AChE), butyrylcholinesterase (BChE) inhibitory potentials, and antioxidant assays. Zinc 56-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 34133127-4 2021 The dual-signal combined nanoprobe (c-PFBT NPs@CdS QDs) served as the matrix to immobilize acetylcholinesterase (AChE) and choline oxidase for organophosphorus (OPs) analysis. Cadmium 47-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 34133127-4 2021 The dual-signal combined nanoprobe (c-PFBT NPs@CdS QDs) served as the matrix to immobilize acetylcholinesterase (AChE) and choline oxidase for organophosphorus (OPs) analysis. Cadmium 47-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 34133127-6 2021 When OPs was present, the activity of AChE was inhibited, the anodic signal would increase, and the cathodic signal would accordingly decrease. OPS 5-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 34308007-1 2021 The canonical mechanism of organophosphate (OP) neurotoxicity is the inhibition of acetylcholinesterase (AChE). Organophosphates 27-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 34308007-1 2021 The canonical mechanism of organophosphate (OP) neurotoxicity is the inhibition of acetylcholinesterase (AChE). Organophosphates 27-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 34120250-4 2021 Furthermore, feeding with supplemented diet with pulp and captopril administration reduced AChE, BChE, ACE, and arginase activities of hypertensive-treated groups. Captopril 58-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 34121977-4 2021 In this study, based on donepezil, which is an effective acetylcholinesterase (AChE) inhibitor, a series of 1,2,4-oxadiazole compounds were designed, synthesized and their inhibitory activities towards AChE and BuChE enzymes were evaluated. Donepezil 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 34121977-4 2021 In this study, based on donepezil, which is an effective acetylcholinesterase (AChE) inhibitor, a series of 1,2,4-oxadiazole compounds were designed, synthesized and their inhibitory activities towards AChE and BuChE enzymes were evaluated. Donepezil 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 34121977-4 2021 In this study, based on donepezil, which is an effective acetylcholinesterase (AChE) inhibitor, a series of 1,2,4-oxadiazole compounds were designed, synthesized and their inhibitory activities towards AChE and BuChE enzymes were evaluated. Donepezil 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-206 34121977-4 2021 In this study, based on donepezil, which is an effective acetylcholinesterase (AChE) inhibitor, a series of 1,2,4-oxadiazole compounds were designed, synthesized and their inhibitory activities towards AChE and BuChE enzymes were evaluated. 1,2,4-Oxadiazole 108-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 34121977-4 2021 In this study, based on donepezil, which is an effective acetylcholinesterase (AChE) inhibitor, a series of 1,2,4-oxadiazole compounds were designed, synthesized and their inhibitory activities towards AChE and BuChE enzymes were evaluated. 1,2,4-Oxadiazole 108-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 34121977-4 2021 In this study, based on donepezil, which is an effective acetylcholinesterase (AChE) inhibitor, a series of 1,2,4-oxadiazole compounds were designed, synthesized and their inhibitory activities towards AChE and BuChE enzymes were evaluated. 1,2,4-Oxadiazole 108-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-206 34820662-1 2021 Intoxication by organophosphorus (OP) poisons, like nerve agents and pesticides, is characterized by the life-threatening inhibition of acetylcholinesterase (AChE) caused by covalent reaction with the serine residue of the active site of the enzyme (phosphylation). organophosphorus 16-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 34820662-1 2021 Intoxication by organophosphorus (OP) poisons, like nerve agents and pesticides, is characterized by the life-threatening inhibition of acetylcholinesterase (AChE) caused by covalent reaction with the serine residue of the active site of the enzyme (phosphylation). organophosphorus 16-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 34820662-1 2021 Intoxication by organophosphorus (OP) poisons, like nerve agents and pesticides, is characterized by the life-threatening inhibition of acetylcholinesterase (AChE) caused by covalent reaction with the serine residue of the active site of the enzyme (phosphylation). Serine 201-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 34820662-1 2021 Intoxication by organophosphorus (OP) poisons, like nerve agents and pesticides, is characterized by the life-threatening inhibition of acetylcholinesterase (AChE) caused by covalent reaction with the serine residue of the active site of the enzyme (phosphylation). Serine 201-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 34719648-0 2021 A Novel Function of Sphingosylphosphorylcholine on the Inhibitory Effects of Acetylcholinesterase Activity. sphingosine phosphorylcholine 20-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 34719648-10 2021 The analysis of SPC analogs clarified the importance of both the quaternary ammonium cation and the carbon chain length of SPC for the AChE inhibitory effect and showed that SPC was unique in AChE inhibition among the sphingolipids in this study. quaternary ammonium cation 65-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 34078793-1 2021 Donepezil, the most widely used drug for the treatment of Alzheimer"s disease (AD), is an acetylcholinesterase (AChE) inhibitor and is thought to improve cognition by stimulating cholinergic neurotransmission. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 34078793-1 2021 Donepezil, the most widely used drug for the treatment of Alzheimer"s disease (AD), is an acetylcholinesterase (AChE) inhibitor and is thought to improve cognition by stimulating cholinergic neurotransmission. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 35421656-2 2022 Specifically, acetylcholinesterase (AChE) hydrolyzes acetylthiocholine into thiocholine (TCh). Acetylthiocholine 53-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 35421656-2 2022 Specifically, acetylcholinesterase (AChE) hydrolyzes acetylthiocholine into thiocholine (TCh). Acetylthiocholine 53-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 35421656-2 2022 Specifically, acetylcholinesterase (AChE) hydrolyzes acetylthiocholine into thiocholine (TCh). Thiocholine 76-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 35421656-2 2022 Specifically, acetylcholinesterase (AChE) hydrolyzes acetylthiocholine into thiocholine (TCh). Thiocholine 76-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 35421656-2 2022 Specifically, acetylcholinesterase (AChE) hydrolyzes acetylthiocholine into thiocholine (TCh). Thiocholine 89-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 35421656-2 2022 Specifically, acetylcholinesterase (AChE) hydrolyzes acetylthiocholine into thiocholine (TCh). Thiocholine 89-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 35421656-5 2022 However, in the presence of OPs, the activity of AChE is suppressed, resulting in a decrease in FI. OPS 28-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 35462163-4 2022 In silico studies confirmed the interaction of benzylpiperidine and the benzylpiperazine isostere with the catalytic anionic site (CAS) of AChE, while the aryloxycarbonyl portion appeared to be important for the interaction with the peripheral site (PAS). 1-benzylpiperidine 47-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 35462163-4 2022 In silico studies confirmed the interaction of benzylpiperidine and the benzylpiperazine isostere with the catalytic anionic site (CAS) of AChE, while the aryloxycarbonyl portion appeared to be important for the interaction with the peripheral site (PAS). benzylpiperazine isostere 72-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 35462163-8 2022 Several piperidine derivatives (in particular compound 10) showed interesting profiles as multi-target directed agents, while the lead piperazine derivative 12 (SON38) was found to be a more potent and selective AChE inhibitor (IC50 = 0.8 nM) than donepezil, besides being able to bind bivalent copper cations (pCu = 7.9 at physiological pH). lead piperazine 130-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 212-216 35462163-8 2022 Several piperidine derivatives (in particular compound 10) showed interesting profiles as multi-target directed agents, while the lead piperazine derivative 12 (SON38) was found to be a more potent and selective AChE inhibitor (IC50 = 0.8 nM) than donepezil, besides being able to bind bivalent copper cations (pCu = 7.9 at physiological pH). Donepezil 248-257 acetylcholinesterase (Cartwright blood group) Homo sapiens 212-216 35462163-8 2022 Several piperidine derivatives (in particular compound 10) showed interesting profiles as multi-target directed agents, while the lead piperazine derivative 12 (SON38) was found to be a more potent and selective AChE inhibitor (IC50 = 0.8 nM) than donepezil, besides being able to bind bivalent copper cations (pCu = 7.9 at physiological pH). Copper 295-301 acetylcholinesterase (Cartwright blood group) Homo sapiens 212-216 35623791-7 2022 Acetylcholinesterase (AChE) as a bio-recognition molecule was immobilized on the glutaraldehyde-chitosan (GLD-CS) modified CdCoS2(2)@Ag electrode surface by cross-linking effect. glutaraldehyde-chitosan 81-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 35623791-7 2022 Acetylcholinesterase (AChE) as a bio-recognition molecule was immobilized on the glutaraldehyde-chitosan (GLD-CS) modified CdCoS2(2)@Ag electrode surface by cross-linking effect. glutaraldehyde-chitosan 81-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 35623791-7 2022 Acetylcholinesterase (AChE) as a bio-recognition molecule was immobilized on the glutaraldehyde-chitosan (GLD-CS) modified CdCoS2(2)@Ag electrode surface by cross-linking effect. gld-cs 106-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 35623791-7 2022 Acetylcholinesterase (AChE) as a bio-recognition molecule was immobilized on the glutaraldehyde-chitosan (GLD-CS) modified CdCoS2(2)@Ag electrode surface by cross-linking effect. gld-cs 106-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 35623791-7 2022 Acetylcholinesterase (AChE) as a bio-recognition molecule was immobilized on the glutaraldehyde-chitosan (GLD-CS) modified CdCoS2(2)@Ag electrode surface by cross-linking effect. cdcos2 123-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 35623791-7 2022 Acetylcholinesterase (AChE) as a bio-recognition molecule was immobilized on the glutaraldehyde-chitosan (GLD-CS) modified CdCoS2(2)@Ag electrode surface by cross-linking effect. cdcos2 123-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 35623791-8 2022 AChE could hydrolyze the acetylcholine chloride (ATCl) to produce an electron donor of thiocholine which led to the elevated photocurrent output. Acetylcholine 25-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 35623791-8 2022 AChE could hydrolyze the acetylcholine chloride (ATCl) to produce an electron donor of thiocholine which led to the elevated photocurrent output. Acetylcholine 49-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 35623791-8 2022 AChE could hydrolyze the acetylcholine chloride (ATCl) to produce an electron donor of thiocholine which led to the elevated photocurrent output. Thiocholine 87-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 35623791-9 2022 When the bioactivity of AChE was inhibited by the organophosphate pesticides (chlorpyrifos as substrate), the reduced production of thiocholine resulted in a decline in photocurrent. Organophosphates 50-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 35623791-9 2022 When the bioactivity of AChE was inhibited by the organophosphate pesticides (chlorpyrifos as substrate), the reduced production of thiocholine resulted in a decline in photocurrent. Chlorpyrifos 78-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 35623791-9 2022 When the bioactivity of AChE was inhibited by the organophosphate pesticides (chlorpyrifos as substrate), the reduced production of thiocholine resulted in a decline in photocurrent. Thiocholine 132-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 35623791-10 2022 Under optimal conditions, the structured AChE/GLD-CS/CdCoS2(2)@Ag/ITO sensing platform was successfully achieved for chlorpyrifos detection. Cesium 50-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 35623791-10 2022 Under optimal conditions, the structured AChE/GLD-CS/CdCoS2(2)@Ag/ITO sensing platform was successfully achieved for chlorpyrifos detection. Chlorpyrifos 117-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 34160494-1 2021 A new photoelectrochemical enzyme biosensor based on an extended-gate field-effect transistor (EGFET) was constructed for the highly sensitive detection of glyphosate based on the inhibition of acetylcholinesterase (AChE) activity by glyphosate. glyphosate 156-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 216-220 34160494-1 2021 A new photoelectrochemical enzyme biosensor based on an extended-gate field-effect transistor (EGFET) was constructed for the highly sensitive detection of glyphosate based on the inhibition of acetylcholinesterase (AChE) activity by glyphosate. glyphosate 234-244 acetylcholinesterase (Cartwright blood group) Homo sapiens 216-220 34160494-3 2021 Then, AChE was immobilized on CdS/ZnO/ITO with chitosan to obtain an AChE/CdS/ZnO EGFET sensor. Zinc Oxide 34-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 34160494-3 2021 Then, AChE was immobilized on CdS/ZnO/ITO with chitosan to obtain an AChE/CdS/ZnO EGFET sensor. indium tin oxide 38-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 34208482-6 2021 In this review, we aimed to compile the research works focused in the anti-AD potential of cyanobacteria, namely regarding the inhibition of the enzyme beta-secretase (BACE1) as a fundamental enzyme in the generation of beta-amyloid (Abeta), the inhibition of the enzyme acetylcholinesterase (AChE) lead to an increase in the availability of the neurotransmitter acetylcholine in the synaptic cleft and the antioxidant and anti-inflammatory effects, as phenomena associated with neurodegeneration mechanisms. Acetylcholine 363-376 acetylcholinesterase (Cartwright blood group) Homo sapiens 293-297 34353435-1 2021 The enzyme acetylcholinesterase (AChE) is a serine hydrolase whose primary function is to degrade acetylcholine (ACh) and terminate neurotransmission. Serine 44-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 34353435-1 2021 The enzyme acetylcholinesterase (AChE) is a serine hydrolase whose primary function is to degrade acetylcholine (ACh) and terminate neurotransmission. Serine 44-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 34353435-1 2021 The enzyme acetylcholinesterase (AChE) is a serine hydrolase whose primary function is to degrade acetylcholine (ACh) and terminate neurotransmission. Acetylcholine 98-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 34353435-1 2021 The enzyme acetylcholinesterase (AChE) is a serine hydrolase whose primary function is to degrade acetylcholine (ACh) and terminate neurotransmission. Acetylcholine 98-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 34353435-1 2021 The enzyme acetylcholinesterase (AChE) is a serine hydrolase whose primary function is to degrade acetylcholine (ACh) and terminate neurotransmission. Acetylcholine 113-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 34353435-1 2021 The enzyme acetylcholinesterase (AChE) is a serine hydrolase whose primary function is to degrade acetylcholine (ACh) and terminate neurotransmission. Acetylcholine 113-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 34193695-1 2021 Flavonoids are potential strikingly natural compounds with antioxidant activity and acetylcholinesterase (AChE) inhibitory activity for treating Alzheimer"s disease (AD). Flavonoids 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 34193695-1 2021 Flavonoids are potential strikingly natural compounds with antioxidant activity and acetylcholinesterase (AChE) inhibitory activity for treating Alzheimer"s disease (AD). Flavonoids 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 34193695-2 2021 In present study, in line with our interests in flavonoid derivatives as AChE inhibitors, a four-dimensional quantitative structure-activity relationship (4D-QSAR) molecular model was proposed. Flavonoids 48-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 34193695-7 2021 The molecular docking analysis was also carried out to understand exceedingly the interactions between flavonoids and the AChE targets, which was in good agreement with the 4D-QSAR model. Flavonoids 103-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 34193695-8 2021 Based on the information provided by the 4D-QSAR model and molecular docking analysis, the idea for optimizing the structures of flavonoids as AChE inhibitors was put forward which maybe provide theoretical guidance for the research and development of new AChE inhibitors. Flavonoids 129-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 34193695-8 2021 Based on the information provided by the 4D-QSAR model and molecular docking analysis, the idea for optimizing the structures of flavonoids as AChE inhibitors was put forward which maybe provide theoretical guidance for the research and development of new AChE inhibitors. Flavonoids 129-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 256-260 34911424-4 2021 Similar positive although variable results have also been found in volumetric measurements of the cortex and whole brain in patients with mild cognitive impairment as well as more advanced AD stages after treatments with all three currently available acetylcholinesterase (AChE) inhibitors (donepezil, rivastigmine, and galantamine). Donepezil 291-300 acetylcholinesterase (Cartwright blood group) Homo sapiens 251-271 34911424-4 2021 Similar positive although variable results have also been found in volumetric measurements of the cortex and whole brain in patients with mild cognitive impairment as well as more advanced AD stages after treatments with all three currently available acetylcholinesterase (AChE) inhibitors (donepezil, rivastigmine, and galantamine). Donepezil 291-300 acetylcholinesterase (Cartwright blood group) Homo sapiens 273-277 34911424-4 2021 Similar positive although variable results have also been found in volumetric measurements of the cortex and whole brain in patients with mild cognitive impairment as well as more advanced AD stages after treatments with all three currently available acetylcholinesterase (AChE) inhibitors (donepezil, rivastigmine, and galantamine). Rivastigmine 302-314 acetylcholinesterase (Cartwright blood group) Homo sapiens 251-271 34911424-4 2021 Similar positive although variable results have also been found in volumetric measurements of the cortex and whole brain in patients with mild cognitive impairment as well as more advanced AD stages after treatments with all three currently available acetylcholinesterase (AChE) inhibitors (donepezil, rivastigmine, and galantamine). Rivastigmine 302-314 acetylcholinesterase (Cartwright blood group) Homo sapiens 273-277 34911424-6 2021 Consistent with the "loss of trophic factor hypothesis of AD," we propose that AChE inhibitors enhance acetylcholine-dependent release and uptake of NGF, thereby sustaining cholinergic neuronal viability and thus lowing AD-associated degeneration of the CBF, to delay dementia progression ultimately. Acetylcholine 103-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 35533565-0 2022 A green photocatalytic-biosensor for colorimetric detection of pesticide (carbaryl) based on inhibition of acetylcholinesterase. Carbaryl 74-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 35533565-4 2022 Meanwhile thiocholine is catalytically produced by acetylcholinesterase (AChE) to directly reduce blue ox-TMB into colorless TMB. Thiocholine 10-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 35533565-4 2022 Meanwhile thiocholine is catalytically produced by acetylcholinesterase (AChE) to directly reduce blue ox-TMB into colorless TMB. Thiocholine 10-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 35533565-4 2022 Meanwhile thiocholine is catalytically produced by acetylcholinesterase (AChE) to directly reduce blue ox-TMB into colorless TMB. 3,3',5,5'-tetramethylbenzidine 106-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 35533565-4 2022 Meanwhile thiocholine is catalytically produced by acetylcholinesterase (AChE) to directly reduce blue ox-TMB into colorless TMB. 3,3',5,5'-tetramethylbenzidine 106-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 35533565-4 2022 Meanwhile thiocholine is catalytically produced by acetylcholinesterase (AChE) to directly reduce blue ox-TMB into colorless TMB. 3,3',5,5'-tetramethylbenzidine 125-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 35533565-4 2022 Meanwhile thiocholine is catalytically produced by acetylcholinesterase (AChE) to directly reduce blue ox-TMB into colorless TMB. 3,3',5,5'-tetramethylbenzidine 125-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 35533565-5 2022 But the activity of AChE will be suppressed by carbaryl, thus generating less thiocholine and resulting in more ox-TMB for colorimetric analysis. Carbaryl 47-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 35533565-5 2022 But the activity of AChE will be suppressed by carbaryl, thus generating less thiocholine and resulting in more ox-TMB for colorimetric analysis. Thiocholine 78-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 35533565-5 2022 But the activity of AChE will be suppressed by carbaryl, thus generating less thiocholine and resulting in more ox-TMB for colorimetric analysis. ox-tmb 112-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 35489467-0 2022 Theoretical assessment of the performances of commercial oximes on the reactivation of acetylcholinesterase inhibited by the nerve agent A-242 (novichok). Oximes 57-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 35489467-2 2022 Once inside the human body, those chemicals act similarly to the classic nerve agents, by binding to the catalytic residue Serine 203 (Ser203) of human acetylcholinesterase (HssAChE) and thus preventing the proper function of this enzyme. Serine 123-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 35489467-2 2022 Once inside the human body, those chemicals act similarly to the classic nerve agents, by binding to the catalytic residue Serine 203 (Ser203) of human acetylcholinesterase (HssAChE) and thus preventing the proper function of this enzyme. Serine 123-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-181 35489467-6 2022 Among those oximes, trimedoxime seems to be the most promising, since it showed lower values of energy in the MM-PBSA calculations, a higher stability inside the catalytic anionic center (CAS) of HssAChE, and was able to adopt a position closer to the NAC that could enable the reactivation mechanism. Trimedoxime 20-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 196-203 35489467-6 2022 Among those oximes, trimedoxime seems to be the most promising, since it showed lower values of energy in the MM-PBSA calculations, a higher stability inside the catalytic anionic center (CAS) of HssAChE, and was able to adopt a position closer to the NAC that could enable the reactivation mechanism. nac 252-255 acetylcholinesterase (Cartwright blood group) Homo sapiens 196-203 35526766-4 2022 Being the first marketed drug for AD, tacrine reversibly inhibits AChE and thereby slows the breakdown of the chemical messenger acetylcholine (ACh) in the brain. Tacrine 38-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 35526766-4 2022 Being the first marketed drug for AD, tacrine reversibly inhibits AChE and thereby slows the breakdown of the chemical messenger acetylcholine (ACh) in the brain. Acetylcholine 129-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 35526766-4 2022 Being the first marketed drug for AD, tacrine reversibly inhibits AChE and thereby slows the breakdown of the chemical messenger acetylcholine (ACh) in the brain. Acetylcholine 144-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 35526766-5 2022 However, the atomic level of interactions of tacrine towards human AChE (hAChE) is unknown for years. Tacrine 45-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 35526766-5 2022 However, the atomic level of interactions of tacrine towards human AChE (hAChE) is unknown for years. Tacrine 45-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-78 35526766-6 2022 Hence, in the current study, we report the X-ray structure of hAChE-tacrine complex at 2.85 A resolution. Tacrine 68-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-67 35526766-7 2022 The conformational heterogeneity of tacrine within the electron density was addressed with the help of molecular mechanics assisted methods and the low-energy ligand configuration is reported, which provides a mechanistic explanation for the high binding affinity of tacrine towards AChE. Tacrine 36-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 283-287 35526766-7 2022 The conformational heterogeneity of tacrine within the electron density was addressed with the help of molecular mechanics assisted methods and the low-energy ligand configuration is reported, which provides a mechanistic explanation for the high binding affinity of tacrine towards AChE. Tacrine 267-274 acetylcholinesterase (Cartwright blood group) Homo sapiens 283-287 35219022-1 2022 There is an urgent need for developing electrochemical biosensor based on the acetylcholinesterase (AChE) inhibition to real-time analysis of organophosphorus pesticides (OPs), but it is suffered from the sluggish electrode kinetics and high oxidation potential toward signal species. organophosphorus 142-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 35583680-3 2022 The oxidized forms of OTPs, so-called oxons, have higher inhibition potentials for AChE. oxons 38-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 35583680-5 2022 In this study, the oxidation of malathion, parathion, and chlorpyrifos by n-bromosuccinimide (NBS) was investigated in an approach combining high-performance thin-layer chromatography (HPTLC) with an AChE-I assay. Malathion 32-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-204 35583680-5 2022 In this study, the oxidation of malathion, parathion, and chlorpyrifos by n-bromosuccinimide (NBS) was investigated in an approach combining high-performance thin-layer chromatography (HPTLC) with an AChE-I assay. Chlorpyrifos 58-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-204 35583680-5 2022 In this study, the oxidation of malathion, parathion, and chlorpyrifos by n-bromosuccinimide (NBS) was investigated in an approach combining high-performance thin-layer chromatography (HPTLC) with an AChE-I assay. Bromosuccinimide 74-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-204 35583680-5 2022 In this study, the oxidation of malathion, parathion, and chlorpyrifos by n-bromosuccinimide (NBS) was investigated in an approach combining high-performance thin-layer chromatography (HPTLC) with an AChE-I assay. Bromosuccinimide 94-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-204 35583680-10 2022 AChE-I effect recoveries in samples from a stormwater retention basin and receiving stream were between 69 and 92% for malathion, parathion, and chlorpyrifos. Malathion 119-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 35583680-10 2022 AChE-I effect recoveries in samples from a stormwater retention basin and receiving stream were between 69 and 92% for malathion, parathion, and chlorpyrifos. Parathion 130-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 35583680-10 2022 AChE-I effect recoveries in samples from a stormwater retention basin and receiving stream were between 69 and 92% for malathion, parathion, and chlorpyrifos. Chlorpyrifos 145-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 35219022-1 2022 There is an urgent need for developing electrochemical biosensor based on the acetylcholinesterase (AChE) inhibition to real-time analysis of organophosphorus pesticides (OPs), but it is suffered from the sluggish electrode kinetics and high oxidation potential toward signal species. organophosphorus 142-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 35219022-3 2022 Then an AChE biosensor based on Cu@GDY was fabricated to detect OPs, and the results revealed that the Cu@GDY nanocomposite can significantly amplifies electrochemical signal and reduces the oxidation potential for OPs. Copper 32-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-12 35219022-3 2022 Then an AChE biosensor based on Cu@GDY was fabricated to detect OPs, and the results revealed that the Cu@GDY nanocomposite can significantly amplifies electrochemical signal and reduces the oxidation potential for OPs. OPS 64-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-12 35219022-3 2022 Then an AChE biosensor based on Cu@GDY was fabricated to detect OPs, and the results revealed that the Cu@GDY nanocomposite can significantly amplifies electrochemical signal and reduces the oxidation potential for OPs. Copper 103-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-12 35602445-9 2022 The roasted-coffee samples had the best inhibition on tyrosinase (88.26 +- 0.15%, p < 0.05), while the raw fruit-EtOH extract showed the highest inhibition on AChE and BChE enzymes (39.10 +- 2.01%, p < 0.01 and 72.69 +- 0.16%, p < 0.016, respectively). Ethanol 113-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 35543317-4 2022 As an example, we analyzed the selective interactions between acetylcholinesterase (AChE) and limonene the major odorant of citrus and an AChE inhibitor using molecular dynamics simulations. Limonene 94-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 35190910-0 2022 Site-activated multi target iron chelators with acetylcholinesterase (AChE) and monoamine oxidase (MAO) inhibitory activities for Alzheimer"s disease therapy. Iron 28-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 35243708-10 2022 CONCLUSION: Tomentosin was isolated in high yield from the paste-like extract of I. viscosa compared to the positive controls, it was determined that tomentosin was weakly effective against hCAI, hCAII, AChE and BChE, but thoroughly effective against alpha-glucosidase and alpha-amylase. tomentosin 12-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 203-207 35543317-4 2022 As an example, we analyzed the selective interactions between acetylcholinesterase (AChE) and limonene the major odorant of citrus and an AChE inhibitor using molecular dynamics simulations. Limonene 94-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 35543317-4 2022 As an example, we analyzed the selective interactions between acetylcholinesterase (AChE) and limonene the major odorant of citrus and an AChE inhibitor using molecular dynamics simulations. Limonene 94-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 35543317-5 2022 In these simulations, limonene was found to be captured at specific binding sites of AChE by modifying the binding site of acetylcholine (ACh), which induced inhibition of the catalytic activity of AChE toward ACh hydrolysis. Limonene 22-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 35543317-5 2022 In these simulations, limonene was found to be captured at specific binding sites of AChE by modifying the binding site of acetylcholine (ACh), which induced inhibition of the catalytic activity of AChE toward ACh hydrolysis. Limonene 22-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-202 35543317-5 2022 In these simulations, limonene was found to be captured at specific binding sites of AChE by modifying the binding site of acetylcholine (ACh), which induced inhibition of the catalytic activity of AChE toward ACh hydrolysis. Acetylcholine 123-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 35579472-1 2022 In this paper, we developed an amplified fluorescence biosensor for acetylcholinesterase (AChE) activity detection by taking advantage of the mercury ion-mediated Mgzyme (Mg2+-dependent DNAzyme) activity. Mercury 142-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 35579472-1 2022 In this paper, we developed an amplified fluorescence biosensor for acetylcholinesterase (AChE) activity detection by taking advantage of the mercury ion-mediated Mgzyme (Mg2+-dependent DNAzyme) activity. magnesium ion 171-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 35579472-4 2022 After the addition of acetylcholinesterase (AChE), the substrate acetylthiocholine could be hydrolyzed to thiocholine, which has a stronger binding power with mercury ions than T-Hg2+-T base pairs. Acetylthiocholine 65-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 35579472-4 2022 After the addition of acetylcholinesterase (AChE), the substrate acetylthiocholine could be hydrolyzed to thiocholine, which has a stronger binding power with mercury ions than T-Hg2+-T base pairs. Thiocholine 106-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 35579472-4 2022 After the addition of acetylcholinesterase (AChE), the substrate acetylthiocholine could be hydrolyzed to thiocholine, which has a stronger binding power with mercury ions than T-Hg2+-T base pairs. Mercury 159-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 35621378-10 2022 In these compounds, huperzine B, huperzinine, lycoposerramine U N-oxide, 12-epilycodine N-oxide showed strongly inhibit the five AChE, BuChE, MAO A, BACE 1 and NMDA targets for Alzheimer"s treatment. huperzine B 20-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 35621378-10 2022 In these compounds, huperzine B, huperzinine, lycoposerramine U N-oxide, 12-epilycodine N-oxide showed strongly inhibit the five AChE, BuChE, MAO A, BACE 1 and NMDA targets for Alzheimer"s treatment. huperzinine 33-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 35621378-10 2022 In these compounds, huperzine B, huperzinine, lycoposerramine U N-oxide, 12-epilycodine N-oxide showed strongly inhibit the five AChE, BuChE, MAO A, BACE 1 and NMDA targets for Alzheimer"s treatment. Lycoposerramine U N-oxide 46-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 35621378-10 2022 In these compounds, huperzine B, huperzinine, lycoposerramine U N-oxide, 12-epilycodine N-oxide showed strongly inhibit the five AChE, BuChE, MAO A, BACE 1 and NMDA targets for Alzheimer"s treatment. 12-epilycodine 73-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 35621378-10 2022 In these compounds, huperzine B, huperzinine, lycoposerramine U N-oxide, 12-epilycodine N-oxide showed strongly inhibit the five AChE, BuChE, MAO A, BACE 1 and NMDA targets for Alzheimer"s treatment. n-oxide 88-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 35623141-4 2022 In addition, ZLWT-37 exhibited lower inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) compared to tacrine. zlwt-37 13-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 35623141-4 2022 In addition, ZLWT-37 exhibited lower inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) compared to tacrine. zlwt-37 13-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 35588856-4 2022 Upon optimum conditions, the constructed AChE sensor showed an ultrahigh sensitivity (0.279 muA/nM), a wide linear range (9.44 x 10-8 - 0.944 mg/L) and a low detection limit (9.44 x 10-8 mg/L) for carbaryl. Carbaryl 197-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 35575998-1 2022 Malathion is a commercially available insecticide that functions by acting as an acetylcholinesterase inhibitor. Malathion 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 35473871-5 2022 Herein, thiocholine could be produced in hydrolysis reaction of acetylthiocholine catalyzed by the acetylcholinesterase (AChE), of which the catalytic activity could be irreversibly inhibitted by the introduction of organophosphates. Thiocholine 8-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 35473871-5 2022 Herein, thiocholine could be produced in hydrolysis reaction of acetylthiocholine catalyzed by the acetylcholinesterase (AChE), of which the catalytic activity could be irreversibly inhibitted by the introduction of organophosphates. Thiocholine 8-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 35473871-5 2022 Herein, thiocholine could be produced in hydrolysis reaction of acetylthiocholine catalyzed by the acetylcholinesterase (AChE), of which the catalytic activity could be irreversibly inhibitted by the introduction of organophosphates. Acetylthiocholine 64-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 35473871-5 2022 Herein, thiocholine could be produced in hydrolysis reaction of acetylthiocholine catalyzed by the acetylcholinesterase (AChE), of which the catalytic activity could be irreversibly inhibitted by the introduction of organophosphates. Acetylthiocholine 64-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 35473871-5 2022 Herein, thiocholine could be produced in hydrolysis reaction of acetylthiocholine catalyzed by the acetylcholinesterase (AChE), of which the catalytic activity could be irreversibly inhibitted by the introduction of organophosphates. Organophosphates 216-232 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 35473871-5 2022 Herein, thiocholine could be produced in hydrolysis reaction of acetylthiocholine catalyzed by the acetylcholinesterase (AChE), of which the catalytic activity could be irreversibly inhibitted by the introduction of organophosphates. Organophosphates 216-232 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 35525893-8 2022 The results of the study suggested that CRE and TC significantly improved the behavioral, biochemical parameters and acetylcholinesterase inhibitory activity in treatment groups. Technetium 48-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 35525893-10 2022 CRE and TC supplementation remarkably downregulated the interleukin-1alpha, tumor necrosis factor-alpha, interleukin-1beta, acetylcholinesterase, and beta-secretase pathological gene expression. Technetium 8-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 35527546-0 2022 A Cobalt-Containing Compound as a Stronger Inhibitor than Galantamine to Inhibit Acetylcholinesterase Activity: A New Drug Candidate for Alzheimer"s Disease Treatment. Cobalt 2-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 35527546-0 2022 A Cobalt-Containing Compound as a Stronger Inhibitor than Galantamine to Inhibit Acetylcholinesterase Activity: A New Drug Candidate for Alzheimer"s Disease Treatment. Galantamine 58-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 35527546-1 2022 BACKGROUND: Acetylcholinesterase (AChE) regulates the transmission of neural messages by hydrolyzing acetylcholine in synaptic spaces. Acetylcholine 101-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 35527546-1 2022 BACKGROUND: Acetylcholinesterase (AChE) regulates the transmission of neural messages by hydrolyzing acetylcholine in synaptic spaces. Acetylcholine 101-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 35527546-7 2022 However, the existence of inhibitors did not eliminate this homotropic state, and even AChE had a more sigmoidal shape than the galantamine at the presence of SC. Scandium 159-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 35527546-10 2022 The number of hydrogen bonds was such that the flexibility of the enzyme protein structure due to inhibitor binding reduced AChE function. Hydrogen 14-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 35599234-1 2022 Nerve agents are a branch of organophosphorus (OP) compounds that chemically cause irreversible inhibition of acetylcholinesterase, thereby failing the hydrolysis of acetylcholine, resulting in severe neurological disease and death in organisms. organophosphorus 29-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 35599234-1 2022 Nerve agents are a branch of organophosphorus (OP) compounds that chemically cause irreversible inhibition of acetylcholinesterase, thereby failing the hydrolysis of acetylcholine, resulting in severe neurological disease and death in organisms. Acetylcholine 166-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 35471452-6 2022 In general, our products were more active against BuChE than against AChE, and it was noted that larger ligands should be prepared for future studies, since in some cases acetylcholine can still fit into the active site along with the bound ligand. Acetylcholine 171-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 35491047-0 2022 Acetylcholinesterase-capped mesoporous silica gated switches for selective detection of high-toxicity organophosphate compounds. mesoporous 28-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 35491047-0 2022 Acetylcholinesterase-capped mesoporous silica gated switches for selective detection of high-toxicity organophosphate compounds. Silicon Dioxide 39-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 35491047-0 2022 Acetylcholinesterase-capped mesoporous silica gated switches for selective detection of high-toxicity organophosphate compounds. Organophosphates 102-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 35491047-5 2022 In this study, a gated switch based on mesoporous silica as an inorganic scaffold loaded with sulforhodamine B and capped with acetylcholinesterase (AChE) was prepared for specific detection of OP compounds. mesoporous silica 39-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 35491047-5 2022 In this study, a gated switch based on mesoporous silica as an inorganic scaffold loaded with sulforhodamine B and capped with acetylcholinesterase (AChE) was prepared for specific detection of OP compounds. mesoporous silica 39-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 35630613-2 2022 Inhibition of AChE slows down the hydrolysis of acetycholine and increases choline levels, improving the cognitive function. acetycholine 48-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 35630613-2 2022 Inhibition of AChE slows down the hydrolysis of acetycholine and increases choline levels, improving the cognitive function. Choline 75-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 35630613-3 2022 The achieved success of plant-based natural drugs acting as AChE inhibitors, such as galantamine (GAL) from Galanthus genus and huperzine A from Huperzia serrate (approved drug in China), in the treatment of AD, and the fact that natural compounds (NCs) are considered as safer and less toxic compared to synthetic drugs, led us to screen the available NCs (almost 150,000) in the ZINC12 database for AChE inhibitory activity. Galantamine 85-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 35630613-3 2022 The achieved success of plant-based natural drugs acting as AChE inhibitors, such as galantamine (GAL) from Galanthus genus and huperzine A from Huperzia serrate (approved drug in China), in the treatment of AD, and the fact that natural compounds (NCs) are considered as safer and less toxic compared to synthetic drugs, led us to screen the available NCs (almost 150,000) in the ZINC12 database for AChE inhibitory activity. Galantamine 98-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 35630613-3 2022 The achieved success of plant-based natural drugs acting as AChE inhibitors, such as galantamine (GAL) from Galanthus genus and huperzine A from Huperzia serrate (approved drug in China), in the treatment of AD, and the fact that natural compounds (NCs) are considered as safer and less toxic compared to synthetic drugs, led us to screen the available NCs (almost 150,000) in the ZINC12 database for AChE inhibitory activity. huperzine A 128-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 35630563-0 2022 Novel and Potent Acetylcholinesterase Inhibitors for the Treatment of Alzheimer"s Disease from Natural (+-)-7,8-Dihydroxy-3-methyl-isochroman-4-one. 7,8-dihydroxy-3-methylisochroman-4-one 108-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 35630563-4 2022 Among them, compound 10a ((Z)-3-acetyl-1-benzyl-4-((6,7-dimethoxy-4-oxoisochroman-3-ylidene)methyl)pyridin-1-ium bromide) possessed potent anti-acetylcholinesterase (AChE) activity as well as modest antioxidant activity. (z)-3-acetyl-1-benzyl-4-((6,7-dimethoxy-4-oxoisochroman-3-ylidene)methyl)pyridin-1-ium bromide 26-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-164 35630563-4 2022 Among them, compound 10a ((Z)-3-acetyl-1-benzyl-4-((6,7-dimethoxy-4-oxoisochroman-3-ylidene)methyl)pyridin-1-ium bromide) possessed potent anti-acetylcholinesterase (AChE) activity as well as modest antioxidant activity. (z)-3-acetyl-1-benzyl-4-((6,7-dimethoxy-4-oxoisochroman-3-ylidene)methyl)pyridin-1-ium bromide 26-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 35630566-7 2022 In addition, the inhibition effects of Coumestrol were tested against the metabolic enzymes acetylcholinesterase (AChE), butyrylcholinesterase (BChE), carbonic anhydrase II (CA II), and alpha-glycosidase, which are associated with some global diseases such as Alzheimer"s disease (AD), glaucoma, and diabetes. Coumestrol 39-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 35630566-7 2022 In addition, the inhibition effects of Coumestrol were tested against the metabolic enzymes acetylcholinesterase (AChE), butyrylcholinesterase (BChE), carbonic anhydrase II (CA II), and alpha-glycosidase, which are associated with some global diseases such as Alzheimer"s disease (AD), glaucoma, and diabetes. Coumestrol 39-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 35543317-5 2022 In these simulations, limonene was found to be captured at specific binding sites of AChE by modifying the binding site of acetylcholine (ACh), which induced inhibition of the catalytic activity of AChE toward ACh hydrolysis. Acetylcholine 123-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-202 35543317-5 2022 In these simulations, limonene was found to be captured at specific binding sites of AChE by modifying the binding site of acetylcholine (ACh), which induced inhibition of the catalytic activity of AChE toward ACh hydrolysis. Acetylcholine 138-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 35543317-5 2022 In these simulations, limonene was found to be captured at specific binding sites of AChE by modifying the binding site of acetylcholine (ACh), which induced inhibition of the catalytic activity of AChE toward ACh hydrolysis. Acetylcholine 138-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-202 35543317-5 2022 In these simulations, limonene was found to be captured at specific binding sites of AChE by modifying the binding site of acetylcholine (ACh), which induced inhibition of the catalytic activity of AChE toward ACh hydrolysis. Acetylcholine 210-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 35543317-5 2022 In these simulations, limonene was found to be captured at specific binding sites of AChE by modifying the binding site of acetylcholine (ACh), which induced inhibition of the catalytic activity of AChE toward ACh hydrolysis. Acetylcholine 210-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-202 35132681-1 2022 A series of novel 4-phenylpiperazine-carbodithioate-N-phenylacetamide hybrids (6a-n) was designed, synthesized, and evaluated for their in vitro inhibitory activity against the metabolic enzymes, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and alpha-glucosidase. 4-phenylpiperazine-carbodithioate-n-phenylacetamide 18-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 196-216 35591210-5 2022 The biosensors were fabricated by immobilizing the acetylcholinesterase (AChE) enzyme on ZnO, which is directly grown on the flexible substrates. Zinc Oxide 89-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 35591210-5 2022 The biosensors were fabricated by immobilizing the acetylcholinesterase (AChE) enzyme on ZnO, which is directly grown on the flexible substrates. Zinc Oxide 89-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 35507043-1 2022 This research was planned to synthesize cyano-acetate derivatives of succinimide and evaluate its comparative biological efficacy as anti-inflammatory, anti-cholinesterase and anti-diabetic, which was further validated by molecular docking studies. cyano-acetate 40-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-171 35507043-1 2022 This research was planned to synthesize cyano-acetate derivatives of succinimide and evaluate its comparative biological efficacy as anti-inflammatory, anti-cholinesterase and anti-diabetic, which was further validated by molecular docking studies. succinimide 69-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-171 35507043-6 2022 They exhibited choline-mimetic potential, such as compound 23, 31 and 44 inhibited AChE enzyme (IC50 value of 240, 174, and 134 microM, respectively) and BChE enzyme (IC50 value of 203, 134 and 97 microM, respectively). Choline 15-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 35563466-5 2022 As a case study, the inhibition of acetylcholinesterase by galantamine, a drug approved for the symptomatic treatment of Alzheimer"s disease, is reported. Galantamine 59-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 35563466-7 2022 Re-examination of acetylcholinesterase inhibition by pre-steady state analysis of the reaction progress curves showed that the potency of galantamine has indeed been underestimated by a factor of ~100. Galantamine 138-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 35294598-1 2022 The present study compares two approaches to evaluate the effects of inter-individual differences in the biotransformation of chlorpyrifos (CPF) on the sensitivity towards in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition and to calculate a chemical-specific adjustment factor (CSAF) to account for inter-individual differences in kinetics (HKAF). Chlorpyrifos 126-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 201-221 35294598-1 2022 The present study compares two approaches to evaluate the effects of inter-individual differences in the biotransformation of chlorpyrifos (CPF) on the sensitivity towards in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition and to calculate a chemical-specific adjustment factor (CSAF) to account for inter-individual differences in kinetics (HKAF). Chlorpyrifos 126-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 223-227 35132681-1 2022 A series of novel 4-phenylpiperazine-carbodithioate-N-phenylacetamide hybrids (6a-n) was designed, synthesized, and evaluated for their in vitro inhibitory activity against the metabolic enzymes, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and alpha-glucosidase. 4-phenylpiperazine-carbodithioate-n-phenylacetamide 18-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 218-222 35199412-5 2022 To this aim, the effect of the newly synthesized thiosemicarbazone derivatives on the activities of acetylcholinesterase (AChE) and alphaglycosidase (alpha-Gly) was evaluated spectrophotometrically. Thiosemicarbazones 49-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 35072877-14 2022 Also, there was a negative correlation between the AChE level and each of SGPT, SGOT, ALP, globulin, blood urea, and serum creatinine for the exposed group reaching a statistically significant level with each of SGPT and SGOT (P < 0.05). Urea 107-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 35072877-14 2022 Also, there was a negative correlation between the AChE level and each of SGPT, SGOT, ALP, globulin, blood urea, and serum creatinine for the exposed group reaching a statistically significant level with each of SGPT and SGOT (P < 0.05). Creatinine 123-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 35199412-5 2022 To this aim, the effect of the newly synthesized thiosemicarbazone derivatives on the activities of acetylcholinesterase (AChE) and alphaglycosidase (alpha-Gly) was evaluated spectrophotometrically. Thiosemicarbazones 49-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 35595404-2 2022 Current pharmacological treatment includes acetylcholinesterase inhibitors (donepezil, galantamine, rivastigmine) and memantine; however, only one-third of patients respond to treatment. Donepezil 76-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 35595404-2 2022 Current pharmacological treatment includes acetylcholinesterase inhibitors (donepezil, galantamine, rivastigmine) and memantine; however, only one-third of patients respond to treatment. Galantamine 87-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 35595404-2 2022 Current pharmacological treatment includes acetylcholinesterase inhibitors (donepezil, galantamine, rivastigmine) and memantine; however, only one-third of patients respond to treatment. Rivastigmine 100-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 35378275-5 2022 Scopoletin modulated multiple molecular signatures in cancer, including AMPK, EGFR, MAPK/ ERK, NF-kappaB, PI3K/Akt/ mTOR, and STAT3 and regulated the levels of critical markers of metabolic diseases such as ALT, AST, TG, and TC; inflammatory diseases such as ILs and TNFs; neurological diseases such as AChE, etc. Scopoletin 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 303-307 35572106-4 2022 Chlorpyrifos as an acetylcholinesterase inhibitor controls the enzymatic hydrolysis reaction and further regulates the production of thiocholine that could decompose CoOOH nanoflakes into Co2+, resulting in the fluorescence response of AuNC-based hydrogel. Chlorpyrifos 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 35572106-4 2022 Chlorpyrifos as an acetylcholinesterase inhibitor controls the enzymatic hydrolysis reaction and further regulates the production of thiocholine that could decompose CoOOH nanoflakes into Co2+, resulting in the fluorescence response of AuNC-based hydrogel. Thiocholine 133-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 35572106-4 2022 Chlorpyrifos as an acetylcholinesterase inhibitor controls the enzymatic hydrolysis reaction and further regulates the production of thiocholine that could decompose CoOOH nanoflakes into Co2+, resulting in the fluorescence response of AuNC-based hydrogel. coooh 166-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 35572106-4 2022 Chlorpyrifos as an acetylcholinesterase inhibitor controls the enzymatic hydrolysis reaction and further regulates the production of thiocholine that could decompose CoOOH nanoflakes into Co2+, resulting in the fluorescence response of AuNC-based hydrogel. Carbon Dioxide 188-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 35624580-6 2022 Finally, we investigated the effects of an inhibitor (rivastigmine) on the AchE activity of the PGFET. Rivastigmine 54-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 35526478-1 2022 The fluorinated bis-pyridinium oximes were designed and synthesized with the aim of increasing their nucleophilicity and potential to reactivate phosphorylated human recombinant acetylcholinesterase (AChE) and human purified plasmatic butyrylcholinesterase (BChE) in relation to chlorinated and non-halogenated oxime analogues. fluorinated bis-pyridinium oximes 4-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-198 35526478-1 2022 The fluorinated bis-pyridinium oximes were designed and synthesized with the aim of increasing their nucleophilicity and potential to reactivate phosphorylated human recombinant acetylcholinesterase (AChE) and human purified plasmatic butyrylcholinesterase (BChE) in relation to chlorinated and non-halogenated oxime analogues. fluorinated bis-pyridinium oximes 4-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-204 35526478-2 2022 Compared to non-halogenated oximes, halogenated oximes showed lower pKa of the oxime group (fluorinated < chlorinated < non-halogenated) along with higher level of oximate anion formation at the physiological pH, and had a higher binding affinity of both AChE and BChE. Oximes 28-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 255-259 35526478-2 2022 Compared to non-halogenated oximes, halogenated oximes showed lower pKa of the oxime group (fluorinated < chlorinated < non-halogenated) along with higher level of oximate anion formation at the physiological pH, and had a higher binding affinity of both AChE and BChE. Oximes 48-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 255-259 35526478-2 2022 Compared to non-halogenated oximes, halogenated oximes showed lower pKa of the oxime group (fluorinated < chlorinated < non-halogenated) along with higher level of oximate anion formation at the physiological pH, and had a higher binding affinity of both AChE and BChE. Oximes 79-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 255-259 35526478-4 2022 Mono-fluorinated oximes showed comparable reactivation to non-halogenated (except asoxime) and mono-chlorinated oximes in case of AChE inhibited by sarin, cyclosarin, VX, and tabun, but were less efficient than di-chlorinated ones. mono-fluorinated oximes 0-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 35526478-4 2022 Mono-fluorinated oximes showed comparable reactivation to non-halogenated (except asoxime) and mono-chlorinated oximes in case of AChE inhibited by sarin, cyclosarin, VX, and tabun, but were less efficient than di-chlorinated ones. asoxime 82-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 35526478-4 2022 Mono-fluorinated oximes showed comparable reactivation to non-halogenated (except asoxime) and mono-chlorinated oximes in case of AChE inhibited by sarin, cyclosarin, VX, and tabun, but were less efficient than di-chlorinated ones. mono-chlorinated oximes 95-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 35526478-4 2022 Mono-fluorinated oximes showed comparable reactivation to non-halogenated (except asoxime) and mono-chlorinated oximes in case of AChE inhibited by sarin, cyclosarin, VX, and tabun, but were less efficient than di-chlorinated ones. Sarin 148-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 35548968-1 2022 AIM: To evaluate the efficacy of combination of alpha-lipoic acid and acetylcholinesterase inhibitor (ipidacrine hydrochloride) to prevent the development and improve the course of paclitaxel-induced peripheral neuropathy (PIPN) in patients with breast cancer according to the Total Neuropathy Score. amiridine 102-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 35548968-7 2022 RESULTS: The use of alpha-lipoic acid in combination with an acetylcholinesterase inhibitor (ipidacrine hydrochloride) significantly reduces the symptoms and severity of PIPN. amiridine 93-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 35626478-6 2022 Docking interaction analysis revealed that Soyasapogenol B bound effectively to all of the targeted proteins (AChE, BuChE MAO-A, MAO-B, GSK3beta, and NMDA), in contrast to other screened abrineurin natural inducers and inhibitors. soyasapogenol B 43-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 35446431-1 2022 INTRODUCTION: The beneficial effect of rivastigmine, an acetylcholinesterase inhibitor (AChEi), which increases levels of acetylcholine (ACh), was first reported in 2013. Rivastigmine 39-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 35563011-3 2022 The combination of rivastigmine and antipsychotic drugs (apart from PNF) enhanced AChE inhibition. Rivastigmine 19-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 35377601-8 2022 Hence, we herein present a series of new 1,3,4-oxadiazoles that are promising leads for the development of dual-acting AChE and BuChE inhibitors for the management of AD. 1,3,4-oxadiazole 41-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 35622619-2 2022 Organophosphorus (OP) compounds are a group of pesticides exerting their toxicological effects through non-reversible inhibition of the enzyme acetylcholinesterase (AChE). organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 35622619-2 2022 Organophosphorus (OP) compounds are a group of pesticides exerting their toxicological effects through non-reversible inhibition of the enzyme acetylcholinesterase (AChE). organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 35442162-0 2022 Synthesis and acetylcholinesterase enzyme inhibitory effects of some novel 4,5-Dihydro-1H-1,2,4-triazol-5-one derivatives; an in vitro and in silico study. 4,5-dihydro-1H-1,2,4-triazol-5-one 75-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 35442162-3 2022 In addition, enzyme inhibitory properties of the newly synthesized Schiff bases were determined against acetylcholinesterase (AChE). Schiff Bases 67-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 35442162-3 2022 In addition, enzyme inhibitory properties of the newly synthesized Schiff bases were determined against acetylcholinesterase (AChE). Schiff Bases 67-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 35385268-2 2022 Herein, CeO2-Co(OH)2 nanosheets were synthesized for the first time in a newly designed deep eutectic solvent (DES) composed of l-proline and Ce(NO3)3 6H2O, and a colorimetric assay was developed for quantitative detection of AChE and anti-neurological disease drug screening. ceo2-co(oh)2 8-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-230 35385268-5 2022 Based on their excellent oxidase-like activity, the CeO2-Co(OH)2 nanosheets have been successfully applied for highly sensitive and selective detection of AChE with a linear range of 0.2-20 mU/mL. ceo2-co(oh)2 52-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 35385268-8 2022 Moreover, five alkaloids, namely, berberine hydrochloride, caffeine, camptothecin, matrine, and evodiamine, were screened by using neostigmine bromide as a control; berberine hydrochloride exhibited a good inhibitory effect on AChE with an IC50 of 0.94 muM, while the other four had no obvious inhibitory effect. berberine chloride 34-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 227-231 35385268-8 2022 Moreover, five alkaloids, namely, berberine hydrochloride, caffeine, camptothecin, matrine, and evodiamine, were screened by using neostigmine bromide as a control; berberine hydrochloride exhibited a good inhibitory effect on AChE with an IC50 of 0.94 muM, while the other four had no obvious inhibitory effect. evodiamine 96-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 227-231 35385268-8 2022 Moreover, five alkaloids, namely, berberine hydrochloride, caffeine, camptothecin, matrine, and evodiamine, were screened by using neostigmine bromide as a control; berberine hydrochloride exhibited a good inhibitory effect on AChE with an IC50 of 0.94 muM, while the other four had no obvious inhibitory effect. berberine chloride 165-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 227-231 35385268-9 2022 The mechanism of the different effects of alkaloids on inhibiting acetylcholinesterase activity was explored via molecular docking and kinetic simulation. Alkaloids 42-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 35462270-11 2022 The binding energies of the complexes, title compound-AChE, donepezil-AChE, and galantamine-AChE, were calculated to be -7.80, -10.41, and -8.16 kcal/mol, respectively. Donepezil 60-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 35462270-11 2022 The binding energies of the complexes, title compound-AChE, donepezil-AChE, and galantamine-AChE, were calculated to be -7.80, -10.41, and -8.16 kcal/mol, respectively. Donepezil 60-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 35462270-11 2022 The binding energies of the complexes, title compound-AChE, donepezil-AChE, and galantamine-AChE, were calculated to be -7.80, -10.41, and -8.16 kcal/mol, respectively. Galantamine 80-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 35007573-9 2022 Suspected drivers of the acetylcholinesterase inhibition are i.e. organophosphorus esters like triphenyl phosphate and cresyldiphenyl phosphate, and the non-ionic surfactant 4-tert-octylphenol ethoxylate. organophosphorus esters 66-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 35007573-9 2022 Suspected drivers of the acetylcholinesterase inhibition are i.e. organophosphorus esters like triphenyl phosphate and cresyldiphenyl phosphate, and the non-ionic surfactant 4-tert-octylphenol ethoxylate. triphenyl phosphate 95-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 35007573-9 2022 Suspected drivers of the acetylcholinesterase inhibition are i.e. organophosphorus esters like triphenyl phosphate and cresyldiphenyl phosphate, and the non-ionic surfactant 4-tert-octylphenol ethoxylate. cresyldiphenyl phosphate 119-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 35007573-9 2022 Suspected drivers of the acetylcholinesterase inhibition are i.e. organophosphorus esters like triphenyl phosphate and cresyldiphenyl phosphate, and the non-ionic surfactant 4-tert-octylphenol ethoxylate. 4-tert-octylphenol ethoxylate 174-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 35420233-6 2022 Our results show that new OPNA reactivators can be discovered rationally by exploiting detailed knowledge of the reactivation mechanism of OPNA-inhibited AChE. opna 139-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-158 35431003-3 2022 On the other hand, acetylcholinesterase, the enzyme responsible for the hydrolysis of acetylcholine, is implicated in cholinergic function. Acetylcholine 86-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 35431003-5 2022 In recent years, the importance of evaluating all possible functions of acetylcholine-acetylcholinesterase has been evidenced. Acetylcholine 72-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 35397086-3 2022 After detailed investigations both in vitro and in silico, novel N-substituted sulfonyl amide derivatives (6a-j) were determined to be highly potent inhibitors for AChE and hCAs (KIs are in the range of 23.11-52.49 nM, 18.66-59.62 nM, and 9.33-120.80 nM for AChE, hCA I, and hCA II, respectively). n-substituted sulfonyl amide 65-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 35397086-3 2022 After detailed investigations both in vitro and in silico, novel N-substituted sulfonyl amide derivatives (6a-j) were determined to be highly potent inhibitors for AChE and hCAs (KIs are in the range of 23.11-52.49 nM, 18.66-59.62 nM, and 9.33-120.80 nM for AChE, hCA I, and hCA II, respectively). n-substituted sulfonyl amide 65-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 258-262 35227980-11 2022 The copper complexes also showed good AChE, BuChE and reactive oxygen species inhibitory activities. Copper 4-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 35411132-11 2022 Results: Molecular docking analysis revealed four putative key targets (ACHE, PNMT, MC1R, and VDR) of HCQ played important roles in vitiligo treatment. Hydroxychloroquine 102-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 35411132-16 2022 The protective effects of HCQ are mediated by binding to putative targets ACHE, PNMT, MC1R, and VDR according to network pharmacology and docking verification. Hydroxychloroquine 26-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 35384306-3 2022 Because of the very strong streptavidin biotin interaction, the AChE immobilization step performed by frontal analysis is very fast (required less than 10 min) and the amount of immobilized AChE was in the microgram range (1mug). Biotin 40-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 35384306-3 2022 Because of the very strong streptavidin biotin interaction, the AChE immobilization step performed by frontal analysis is very fast (required less than 10 min) and the amount of immobilized AChE was in the microgram range (1mug). Biotin 40-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 190-194 35384306-7 2022 In addition, it was demonstrated that competitive experiments could be performed with our miniaturized system to confirm the existence and the binding pocket of a ligand to AChE contained in a methanol plant extract. Methanol 193-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-177 35090939-4 2022 The N,2-diphenyl-2-(phenylsulfonamido)acetamide derivatives, thus designed, were synthesised and screened for the inhibition of AChE and BChE enzymes. n,2-diphenyl-2-(phenylsulfonamido)acetamide 4-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 35225413-6 2022 It should be noted that most of the synthesized compounds were more potent than standard inhibitor tacrine (TAC) against AChE. Tacrine 99-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 35225413-6 2022 It should be noted that most of the synthesized compounds were more potent than standard inhibitor tacrine (TAC) against AChE. Tacrine 108-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 35447920-0 2022 Simultaneous Inhibitory Effects of All-Trans Astaxanthin on Acetylcholinesterase and Oxidative Stress. astaxanthine 45-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 35447920-3 2022 In this study, the inhibition effect of all-trans astaxanthin mainly from marine organisms on acetylcholinesterase and oxidative stress was evaluated by a chemical-based method in vitro and cell assay model. astaxanthine 50-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 35447920-6 2022 All-trans astaxanthin could induce the changes of the secondary structure to reduce acetylcholinesterase activity. all-trans 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 35447920-6 2022 All-trans astaxanthin could induce the changes of the secondary structure to reduce acetylcholinesterase activity. astaxanthine 10-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 35447920-7 2022 Molecular-docking analysis reveals that all-trans astaxanthin prevented substrate from binding to acetylcholinesterase by occupying the space of the active pocket to cause the inhibition. astaxanthine 50-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-118 35346014-9 2022 The studied molecules interacted with the active site of AChE through hydrophobic and hydrogen bonds and with NOS through hydrogen interactions only but in a meaningful manner. Hydrogen 86-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 35455397-3 2022 5-Aryl-1,3,4-oxadiazoles decorated with dodecyl linked via nitrogen, sulfur or directly to this heterocycle have been designed as potential inhibitors of AChE and BChE. 5-aryl-1,3,4-oxadiazoles 0-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-158 35455397-11 2022 Many oxadiazoles showed lower IC50 values against AChE than established drug rivastigmine. Oxadiazoles 5-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 35455397-11 2022 Many oxadiazoles showed lower IC50 values against AChE than established drug rivastigmine. Rivastigmine 77-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 35408132-1 2022 Azamethiphos (AZA) is an insecticide and neurotoxic agent that causes the inhibition of acetylcholinesterase (AChE). azamethiphos 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 35408132-1 2022 Azamethiphos (AZA) is an insecticide and neurotoxic agent that causes the inhibition of acetylcholinesterase (AChE). azamethiphos 14-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 35408132-1 2022 Azamethiphos (AZA) is an insecticide and neurotoxic agent that causes the inhibition of acetylcholinesterase (AChE). azamethiphos 14-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 35408132-2 2022 AChE is a vital enzyme for neurotransmission because it metabolizes acetylcholine neurotransmitter at the synaptic cleft and terminates synaptic transmission. Acetylcholine 68-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 35408132-3 2022 It is worth mentioning that organophosphates and carbamates inhibit AChE. Organophosphates 28-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 35408132-3 2022 It is worth mentioning that organophosphates and carbamates inhibit AChE. Carbamates 49-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 35276042-5 2022 Using spectroscopic ellipsometry, we determined that the surface concentration of AChE on a saturated Au surface in a buffered solution was 2.77 +- 0.21 pmol cm-2. Gold 102-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 35276042-6 2022 By calculating the molecular volume of hydrated AChE, corresponding to a sphere of 6.19 nm diameter, divided by the total volume at the AChE-Au interface, we obtain a surface packing density of 33.4 +- 2.5% by volume. Gold 141-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 35276042-6 2022 By calculating the molecular volume of hydrated AChE, corresponding to a sphere of 6.19 nm diameter, divided by the total volume at the AChE-Au interface, we obtain a surface packing density of 33.4 +- 2.5% by volume. Gold 141-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 35195417-1 2022 Bioisosteric H/F or CH2OH/CF2H replacement was introduced in coumarin derivatives previously characterized as dual AChE-MAO B inhibitors to probe the effects on both inhibitory potency and drug-likeness. coumarin 61-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 35195417-4 2022 Compound 15 bearing a -CF2H motif emerged as a water-soluble, orally bioavailable CNS-permeant potent inhibitor of both human AChE (IC50 = 550 nM) and MAO B (IC50 = 8.2 nM, B/A selectivity > 1200). cf2h 23-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 35195417-4 2022 Compound 15 bearing a -CF2H motif emerged as a water-soluble, orally bioavailable CNS-permeant potent inhibitor of both human AChE (IC50 = 550 nM) and MAO B (IC50 = 8.2 nM, B/A selectivity > 1200). Water 47-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 35424765-0 2022 Facile preparation of fluorescent water-soluble non-conjugated polymer dots and fabricating an acetylcholinesterase biosensor. Water 34-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 35424765-0 2022 Facile preparation of fluorescent water-soluble non-conjugated polymer dots and fabricating an acetylcholinesterase biosensor. Polymers 63-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 35424765-7 2022 The NCPDs-MnO2 biosensing system showed a broader detection range from 12.3 to 3675 U L-1 for AChE and the limit of detection (LOD) was as low as 4.9 U L-1. manganese dioxide 10-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 35101650-2 2022 Two main scaffolds namely: pyrazolopyridine and tetrahydroacridine (THA) were used to synthesize four different series of integrated multi-targeted synthons possessing ChE (hAChE or hBuChE), Abeta1-42 aggregation inhibition potency, in addition to optimum metal chelating capability. pyrazolopyridine 27-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-178 35101650-2 2022 Two main scaffolds namely: pyrazolopyridine and tetrahydroacridine (THA) were used to synthesize four different series of integrated multi-targeted synthons possessing ChE (hAChE or hBuChE), Abeta1-42 aggregation inhibition potency, in addition to optimum metal chelating capability. 1,2,3,4-Tetrahydroacridine 48-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-178 35101650-2 2022 Two main scaffolds namely: pyrazolopyridine and tetrahydroacridine (THA) were used to synthesize four different series of integrated multi-targeted synthons possessing ChE (hAChE or hBuChE), Abeta1-42 aggregation inhibition potency, in addition to optimum metal chelating capability. tha 68-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-178 35101650-2 2022 Two main scaffolds namely: pyrazolopyridine and tetrahydroacridine (THA) were used to synthesize four different series of integrated multi-targeted synthons possessing ChE (hAChE or hBuChE), Abeta1-42 aggregation inhibition potency, in addition to optimum metal chelating capability. 2-(N-cyclohexylamino)ethanesulfonic acid 168-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-178 35101650-4 2022 Different 9-amino substitutions improved the in vitro hAChE activity of 7- or 6,7-disubstituted THA derivatives. tha 96-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-59 35166114-5 2022 Interestingly, the 2D CMNSs with peroxidase-like properties exhibited a unique response to thiol compounds and were thus employed as highly efficient catalysts to develop HEC sensors for OPs based on the hydrolysis of acetylthiocholine (ATCh) to form thiocholine catalyzed by acetylcholinesterase (AChE) and the inhibition of AChE activity by OPs. Sulfhydryl Compounds 91-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 276-296 35166114-5 2022 Interestingly, the 2D CMNSs with peroxidase-like properties exhibited a unique response to thiol compounds and were thus employed as highly efficient catalysts to develop HEC sensors for OPs based on the hydrolysis of acetylthiocholine (ATCh) to form thiocholine catalyzed by acetylcholinesterase (AChE) and the inhibition of AChE activity by OPs. Sulfhydryl Compounds 91-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 298-302 35166114-5 2022 Interestingly, the 2D CMNSs with peroxidase-like properties exhibited a unique response to thiol compounds and were thus employed as highly efficient catalysts to develop HEC sensors for OPs based on the hydrolysis of acetylthiocholine (ATCh) to form thiocholine catalyzed by acetylcholinesterase (AChE) and the inhibition of AChE activity by OPs. Sulfhydryl Compounds 91-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 326-330 35166114-5 2022 Interestingly, the 2D CMNSs with peroxidase-like properties exhibited a unique response to thiol compounds and were thus employed as highly efficient catalysts to develop HEC sensors for OPs based on the hydrolysis of acetylthiocholine (ATCh) to form thiocholine catalyzed by acetylcholinesterase (AChE) and the inhibition of AChE activity by OPs. Acetylthiocholine 218-235 acetylcholinesterase (Cartwright blood group) Homo sapiens 276-296 35166114-5 2022 Interestingly, the 2D CMNSs with peroxidase-like properties exhibited a unique response to thiol compounds and were thus employed as highly efficient catalysts to develop HEC sensors for OPs based on the hydrolysis of acetylthiocholine (ATCh) to form thiocholine catalyzed by acetylcholinesterase (AChE) and the inhibition of AChE activity by OPs. Acetylthiocholine 218-235 acetylcholinesterase (Cartwright blood group) Homo sapiens 298-302 35166114-5 2022 Interestingly, the 2D CMNSs with peroxidase-like properties exhibited a unique response to thiol compounds and were thus employed as highly efficient catalysts to develop HEC sensors for OPs based on the hydrolysis of acetylthiocholine (ATCh) to form thiocholine catalyzed by acetylcholinesterase (AChE) and the inhibition of AChE activity by OPs. Acetylthiocholine 218-235 acetylcholinesterase (Cartwright blood group) Homo sapiens 326-330 35166114-5 2022 Interestingly, the 2D CMNSs with peroxidase-like properties exhibited a unique response to thiol compounds and were thus employed as highly efficient catalysts to develop HEC sensors for OPs based on the hydrolysis of acetylthiocholine (ATCh) to form thiocholine catalyzed by acetylcholinesterase (AChE) and the inhibition of AChE activity by OPs. Thiocholine 251-262 acetylcholinesterase (Cartwright blood group) Homo sapiens 276-296 35166114-5 2022 Interestingly, the 2D CMNSs with peroxidase-like properties exhibited a unique response to thiol compounds and were thus employed as highly efficient catalysts to develop HEC sensors for OPs based on the hydrolysis of acetylthiocholine (ATCh) to form thiocholine catalyzed by acetylcholinesterase (AChE) and the inhibition of AChE activity by OPs. Thiocholine 251-262 acetylcholinesterase (Cartwright blood group) Homo sapiens 298-302 35166114-5 2022 Interestingly, the 2D CMNSs with peroxidase-like properties exhibited a unique response to thiol compounds and were thus employed as highly efficient catalysts to develop HEC sensors for OPs based on the hydrolysis of acetylthiocholine (ATCh) to form thiocholine catalyzed by acetylcholinesterase (AChE) and the inhibition of AChE activity by OPs. Thiocholine 251-262 acetylcholinesterase (Cartwright blood group) Homo sapiens 326-330 35114523-6 2022 Aporphine alkaloids are recognized for their acetylcholinesterase (AChE) inhibitory activity, an important target in Alzheimer"s disease therapy. aporphine alkaloids 0-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 35085532-5 2022 Berberine had an antagonistic effect for the majority of genes mutual for AD and toxic metal mixture: ACHE, APP, BAX, BCL2, CASP3, HMOX1, IL1B, MAPT, SOD2, TNF. Berberine 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 35098414-3 2022 To enhance the declined level of acetylcholine (ACh) resulting from loss of cholinergic neurons, acetylcholinesterase (AChE) inhibitors are developed and successfully approved for AD treatment in the clinic, with a limited therapeutic effectiveness. Acetylcholine 33-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 35098414-3 2022 To enhance the declined level of acetylcholine (ACh) resulting from loss of cholinergic neurons, acetylcholinesterase (AChE) inhibitors are developed and successfully approved for AD treatment in the clinic, with a limited therapeutic effectiveness. Acetylcholine 33-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 35098414-3 2022 To enhance the declined level of acetylcholine (ACh) resulting from loss of cholinergic neurons, acetylcholinesterase (AChE) inhibitors are developed and successfully approved for AD treatment in the clinic, with a limited therapeutic effectiveness. Acetylcholine 48-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 35098414-3 2022 To enhance the declined level of acetylcholine (ACh) resulting from loss of cholinergic neurons, acetylcholinesterase (AChE) inhibitors are developed and successfully approved for AD treatment in the clinic, with a limited therapeutic effectiveness. Acetylcholine 48-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 35098414-5 2022 Accumulated evidence reveals that Kv channels, which are broadly expressed in brain and possess crucial functions in modulating the neuronal activity, are inhibited by several acetylcholinesterase (AChE) inhibitors, such as tacrine, bis(7)-tacrine, donepezil and galantamine. Tacrine 224-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-196 35098414-5 2022 Accumulated evidence reveals that Kv channels, which are broadly expressed in brain and possess crucial functions in modulating the neuronal activity, are inhibited by several acetylcholinesterase (AChE) inhibitors, such as tacrine, bis(7)-tacrine, donepezil and galantamine. Tacrine 224-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-202 35446431-1 2022 INTRODUCTION: The beneficial effect of rivastigmine, an acetylcholinesterase inhibitor (AChEi), which increases levels of acetylcholine (ACh), was first reported in 2013. Acetylcholine 122-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 35446431-1 2022 INTRODUCTION: The beneficial effect of rivastigmine, an acetylcholinesterase inhibitor (AChEi), which increases levels of acetylcholine (ACh), was first reported in 2013. Acetylcholine 137-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 34994010-4 2022 Compound 2d showed the most potent inhibitory activity among the tested molecules toward AChE and BChE (IC50 = 15.07 and 14.15 nM) compared to the standard drug neostigmine. Neostigmine 162-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 35182888-0 2022 Synthesis, structure and acetylcholinesterase inhibition activity of new diarylpyrazoles. diarylpyrazoles 73-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 35527825-2 2022 We developed a novel QSAR regression model for estimating potency to inhibit AChE, pK i, on a set of 75 structurally different compounds including oximes, N-hydroxyiminoacetamides, 4-aminoquinolines and flavonoids. Oximes 147-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 35527825-2 2022 We developed a novel QSAR regression model for estimating potency to inhibit AChE, pK i, on a set of 75 structurally different compounds including oximes, N-hydroxyiminoacetamides, 4-aminoquinolines and flavonoids. n-hydroxyiminoacetamides 155-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 35527825-2 2022 We developed a novel QSAR regression model for estimating potency to inhibit AChE, pK i, on a set of 75 structurally different compounds including oximes, N-hydroxyiminoacetamides, 4-aminoquinolines and flavonoids. 4-aminoquinoline 181-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 35527825-2 2022 We developed a novel QSAR regression model for estimating potency to inhibit AChE, pK i, on a set of 75 structurally different compounds including oximes, N-hydroxyiminoacetamides, 4-aminoquinolines and flavonoids. Flavonoids 203-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 35355036-0 2022 Modulation of acetylcholinesterase activity using molecularly imprinted polymer nanoparticles. Polymers 72-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 35355036-5 2022 The impact of nanoMIPs on the inhibited enzyme is also explored, with AChE activity recovering from 11% (following exposure to an organophosphate) to 73% (following the addition of nanoMIPs). Organophosphates 130-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 35455405-11 2022 TQ has been shown in clinical studies to block acetylcholinesterase (AChE) activity, which increases acetylcholine (ACh). Acetylcholine 101-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 35455405-11 2022 TQ has been shown in clinical studies to block acetylcholinesterase (AChE) activity, which increases acetylcholine (ACh). Acetylcholine 101-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 35455405-11 2022 TQ has been shown in clinical studies to block acetylcholinesterase (AChE) activity, which increases acetylcholine (ACh). Acetylcholine 116-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 35455405-11 2022 TQ has been shown in clinical studies to block acetylcholinesterase (AChE) activity, which increases acetylcholine (ACh). Acetylcholine 116-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 35408542-5 2022 In this work, 21 novel hybrids of BMT and coumarin were synthesized and evaluated for their inhibitory activity on AChE. coumarin 42-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 35408519-6 2022 The reference drug donepezil (IC50 = 0.021 microM) also showed significant inhibition against AChE. Donepezil 19-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 35408132-1 2022 Azamethiphos (AZA) is an insecticide and neurotoxic agent that causes the inhibition of acetylcholinesterase (AChE). azamethiphos 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 35255209-2 2022 The current therapy includes a pyridinium aldoxime reactivator to restore the enzymatic activity of acetylcholinesterase located in the central nervous system and neuro-muscular junctions. pyridinium aldoxime 31-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 35310033-5 2022 In this review, a systematic survey was executed to collect the literature on alkaloids and their health complications, from which we found that majority of alkaloids exhibit anti-inflammatory action via nuclear factor-kappaB and cyclooxygenase-2 (COX-2), and neuroprotective interaction through acetylcholinesterase (AChE), COX, and beta-site amyloid precursor protein activity. Alkaloids 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 296-316 35310033-5 2022 In this review, a systematic survey was executed to collect the literature on alkaloids and their health complications, from which we found that majority of alkaloids exhibit anti-inflammatory action via nuclear factor-kappaB and cyclooxygenase-2 (COX-2), and neuroprotective interaction through acetylcholinesterase (AChE), COX, and beta-site amyloid precursor protein activity. Alkaloids 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 318-322 35310033-5 2022 In this review, a systematic survey was executed to collect the literature on alkaloids and their health complications, from which we found that majority of alkaloids exhibit anti-inflammatory action via nuclear factor-kappaB and cyclooxygenase-2 (COX-2), and neuroprotective interaction through acetylcholinesterase (AChE), COX, and beta-site amyloid precursor protein activity. Alkaloids 157-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 296-316 35310033-5 2022 In this review, a systematic survey was executed to collect the literature on alkaloids and their health complications, from which we found that majority of alkaloids exhibit anti-inflammatory action via nuclear factor-kappaB and cyclooxygenase-2 (COX-2), and neuroprotective interaction through acetylcholinesterase (AChE), COX, and beta-site amyloid precursor protein activity. Alkaloids 157-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 318-322 35258696-0 2022 An arginine-rich peptide inhibits AChE: template-based design, molecular modeling, synthesis, and biological evaluation. Arginine 3-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 35258696-4 2022 AChE, as a well-known target in AD, decreases the acetylcholine (ACh) in cholinergic synapse and, besides, increases the rate of amyloid-beta (Abeta) aggregation. Acetylcholine 50-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 35258696-4 2022 AChE, as a well-known target in AD, decreases the acetylcholine (ACh) in cholinergic synapse and, besides, increases the rate of amyloid-beta (Abeta) aggregation. Acetylcholine 65-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 35098414-5 2022 Accumulated evidence reveals that Kv channels, which are broadly expressed in brain and possess crucial functions in modulating the neuronal activity, are inhibited by several acetylcholinesterase (AChE) inhibitors, such as tacrine, bis(7)-tacrine, donepezil and galantamine. 1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydroacridine 233-247 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-196 35098414-5 2022 Accumulated evidence reveals that Kv channels, which are broadly expressed in brain and possess crucial functions in modulating the neuronal activity, are inhibited by several acetylcholinesterase (AChE) inhibitors, such as tacrine, bis(7)-tacrine, donepezil and galantamine. 1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydroacridine 233-247 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-202 35098414-5 2022 Accumulated evidence reveals that Kv channels, which are broadly expressed in brain and possess crucial functions in modulating the neuronal activity, are inhibited by several acetylcholinesterase (AChE) inhibitors, such as tacrine, bis(7)-tacrine, donepezil and galantamine. Donepezil 249-258 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-196 35098414-5 2022 Accumulated evidence reveals that Kv channels, which are broadly expressed in brain and possess crucial functions in modulating the neuronal activity, are inhibited by several acetylcholinesterase (AChE) inhibitors, such as tacrine, bis(7)-tacrine, donepezil and galantamine. Donepezil 249-258 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-202 35098414-5 2022 Accumulated evidence reveals that Kv channels, which are broadly expressed in brain and possess crucial functions in modulating the neuronal activity, are inhibited by several acetylcholinesterase (AChE) inhibitors, such as tacrine, bis(7)-tacrine, donepezil and galantamine. Galantamine 263-274 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-196 35098414-5 2022 Accumulated evidence reveals that Kv channels, which are broadly expressed in brain and possess crucial functions in modulating the neuronal activity, are inhibited by several acetylcholinesterase (AChE) inhibitors, such as tacrine, bis(7)-tacrine, donepezil and galantamine. Galantamine 263-274 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-202 35098414-6 2022 Inhibition of Kv channels by these AChE inhibitors can generate neuroprotective effects by either mitigating Abeta toxicity and neuronal apoptosis, or facilitating cell proliferation. UNII-042A8N37WH 109-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 35526478-4 2022 Mono-fluorinated oximes showed comparable reactivation to non-halogenated (except asoxime) and mono-chlorinated oximes in case of AChE inhibited by sarin, cyclosarin, VX, and tabun, but were less efficient than di-chlorinated ones. cyclohexyl methylphosphonofluoridate 155-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 35526478-4 2022 Mono-fluorinated oximes showed comparable reactivation to non-halogenated (except asoxime) and mono-chlorinated oximes in case of AChE inhibited by sarin, cyclosarin, VX, and tabun, but were less efficient than di-chlorinated ones. VX 167-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 35526478-4 2022 Mono-fluorinated oximes showed comparable reactivation to non-halogenated (except asoxime) and mono-chlorinated oximes in case of AChE inhibited by sarin, cyclosarin, VX, and tabun, but were less efficient than di-chlorinated ones. tabun 175-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 35526478-4 2022 Mono-fluorinated oximes showed comparable reactivation to non-halogenated (except asoxime) and mono-chlorinated oximes in case of AChE inhibited by sarin, cyclosarin, VX, and tabun, but were less efficient than di-chlorinated ones. di-chlorinated 211-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 35526478-6 2022 The advantage of halogen substituents in the stabilization of oxime in a position optimal for in-line nucleophilic attack were confirmed by extensive molecular modelling of pre-reactivation complexes between the analogue oximes and phosphorylated AChE and BChE. Oximes 62-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 247-251 35526478-6 2022 The advantage of halogen substituents in the stabilization of oxime in a position optimal for in-line nucleophilic attack were confirmed by extensive molecular modelling of pre-reactivation complexes between the analogue oximes and phosphorylated AChE and BChE. Oximes 221-227 acetylcholinesterase (Cartwright blood group) Homo sapiens 247-251 35402070-2 2022 Abnormally elevated levels of acetylcholinesterase (AChE) resulting in decreased levels of ACh are common in AD patients; thus, AChE inhibitors (AChEIs) are widely used for the treatment of AD. Acetylcholine 91-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 35243936-0 2022 Synthesis and molecular modelling of thiadizole based hydrazone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitory activities. thiadizole 37-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 35243936-0 2022 Synthesis and molecular modelling of thiadizole based hydrazone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitory activities. Hydrazones 54-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 35243936-1 2022 Some novel substituted thiazolylhydrazine derivatives were designed, synthesized and their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes and antioxidant activities were investigated. thiazolylhydrazine 23-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-133 35243936-1 2022 Some novel substituted thiazolylhydrazine derivatives were designed, synthesized and their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes and antioxidant activities were investigated. thiazolylhydrazine 23-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 35402070-2 2022 Abnormally elevated levels of acetylcholinesterase (AChE) resulting in decreased levels of ACh are common in AD patients; thus, AChE inhibitors (AChEIs) are widely used for the treatment of AD. Acetylcholine 91-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 35402070-2 2022 Abnormally elevated levels of acetylcholinesterase (AChE) resulting in decreased levels of ACh are common in AD patients; thus, AChE inhibitors (AChEIs) are widely used for the treatment of AD. Acetylcholine 91-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 35300078-0 2022 Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures. coumarin 16-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 35212831-13 2022 CP + SCOP induced a concentration-dependent increase in AChE inhibition and ACh depletion. Scopolamine 5-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 35137748-16 2022 Using virtual docking to the active sites of the human acetylcholinesterase crystal structure, salvianolic acid K, rosmarinic acid and salvianolic acid C showed the best fitting binding modes to active sites of acetylcholinesterase. salvianolic acid C 135-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-231 35216144-13 2022 The blood AChE is able to terminate the stimulation of the cholinergic anti-inflammatory pathway due to splitting ACh. Acetylcholine 114-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-14 35216144-18 2022 This signaling process ends when ACh is hydrolyzed by acetylcholinesterase (AChE). Acetylcholine 33-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 35216144-19 2022 There are many scientific reports indicating the harmful effects of ACR on AChE. Acrylamide 68-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 35216144-20 2022 Most of them indicate that ACR reduces the concentration and activity of AChE. Acrylamide 27-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 35146638-8 2022 Therefore, from this in silico based study, we report that Mangiferin could be a potential molecule targeting Wnt signaling pathway modulating the LRP6 activity, Baicalin for AChE activity, Chebulic acid for DKK1, ZINC103539689 for WIF1, and Morin for GSk-3beta protein. mangiferin 59-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 175-179 35208411-1 2022 According to the current model of nerve propagation, the function of acetylcholinesterase (AChE) is to terminate synaptic transmission of nerve signals by hydrolyzing the neurotransmitter acetylcholine (ACh) in the synaptic cleft to acetic acid (acetate) and choline. Acetylcholine 188-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 35208411-1 2022 According to the current model of nerve propagation, the function of acetylcholinesterase (AChE) is to terminate synaptic transmission of nerve signals by hydrolyzing the neurotransmitter acetylcholine (ACh) in the synaptic cleft to acetic acid (acetate) and choline. Acetylcholine 188-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 35208411-1 2022 According to the current model of nerve propagation, the function of acetylcholinesterase (AChE) is to terminate synaptic transmission of nerve signals by hydrolyzing the neurotransmitter acetylcholine (ACh) in the synaptic cleft to acetic acid (acetate) and choline. Acetylcholine 203-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 35208411-1 2022 According to the current model of nerve propagation, the function of acetylcholinesterase (AChE) is to terminate synaptic transmission of nerve signals by hydrolyzing the neurotransmitter acetylcholine (ACh) in the synaptic cleft to acetic acid (acetate) and choline. Acetylcholine 203-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 35208411-1 2022 According to the current model of nerve propagation, the function of acetylcholinesterase (AChE) is to terminate synaptic transmission of nerve signals by hydrolyzing the neurotransmitter acetylcholine (ACh) in the synaptic cleft to acetic acid (acetate) and choline. Acetic Acid 233-244 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 35208411-1 2022 According to the current model of nerve propagation, the function of acetylcholinesterase (AChE) is to terminate synaptic transmission of nerve signals by hydrolyzing the neurotransmitter acetylcholine (ACh) in the synaptic cleft to acetic acid (acetate) and choline. Acetic Acid 233-244 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 35208411-1 2022 According to the current model of nerve propagation, the function of acetylcholinesterase (AChE) is to terminate synaptic transmission of nerve signals by hydrolyzing the neurotransmitter acetylcholine (ACh) in the synaptic cleft to acetic acid (acetate) and choline. Acetates 246-253 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 35208411-1 2022 According to the current model of nerve propagation, the function of acetylcholinesterase (AChE) is to terminate synaptic transmission of nerve signals by hydrolyzing the neurotransmitter acetylcholine (ACh) in the synaptic cleft to acetic acid (acetate) and choline. Acetates 246-253 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 35208411-1 2022 According to the current model of nerve propagation, the function of acetylcholinesterase (AChE) is to terminate synaptic transmission of nerve signals by hydrolyzing the neurotransmitter acetylcholine (ACh) in the synaptic cleft to acetic acid (acetate) and choline. Choline 259-266 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 35208411-1 2022 According to the current model of nerve propagation, the function of acetylcholinesterase (AChE) is to terminate synaptic transmission of nerve signals by hydrolyzing the neurotransmitter acetylcholine (ACh) in the synaptic cleft to acetic acid (acetate) and choline. Choline 259-266 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 35243363-6 2022 5) Age-related refinements for CPF/CPFO were primarily from ToxCast/Tox21 active hit-calls for nuclear receptors, CYP2B6 and AChE inhibition (CPFO only) associated with the metabolic pathway. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 35-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 35243363-6 2022 5) Age-related refinements for CPF/CPFO were primarily from ToxCast/Tox21 active hit-calls for nuclear receptors, CYP2B6 and AChE inhibition (CPFO only) associated with the metabolic pathway. O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate 142-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 35164361-1 2022 A family of novel efficient non-oxime compounds exhibited promising reactivation efficacy for VX and sarin inhibited human acetylcholinesterase was discovered. Oximes 32-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-143 35164361-1 2022 A family of novel efficient non-oxime compounds exhibited promising reactivation efficacy for VX and sarin inhibited human acetylcholinesterase was discovered. Sarin 101-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-143 34995924-0 2022 Discovery of novel beta-carboline derivatives as selective AChE inhibitors with GSK-3beta inhibitory property for the treatment of Alzheimer"s disease. norharman 19-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 34995924-4 2022 In particular, compound ZLWH-23 exhibited potent anti-AChE activity (IC50 = 0.27 muM) and selective BChE inhibition (IC50 = 20.82 muM), as well as acceptable glycogen synthase kinase-3 (GSK-3beta) inhibition (IC50 = 6.78 muM). ZLWH-23 24-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 34995924-5 2022 Molecular docking studies and molecular dynamics simulations indicated that ZLWH-23 could form stable interaction with AChE and GSK-3beta. zlwh 76-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 35164325-0 2022 Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: N-Functionalization Determines the Multitarget Anti-Alzheimer"s Activity Profile. bis-amiridines 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 35057959-3 2022 In this study, a pH-sensitive colorimetric biosensing strategy was developed for exosomes detection by integrating stimuli-responsive DNA microcapsules and acetylcholinesterase to produce acetic acid. Acetic Acid 188-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-176 34874369-1 2022 We report a choline ester-grafted turn-on fluorescence probe to detect acetylcholinesterase (AChE) in living cells. choline ester 12-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 34874369-2 2022 The AChE-mediated hydrolysis of the choline ester moiety producing carboxylate initiates the activation of the Cy5 fluorophore quenched by an intramolecular nucleophilic mercapto group. choline ester 36-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 34874369-2 2022 The AChE-mediated hydrolysis of the choline ester moiety producing carboxylate initiates the activation of the Cy5 fluorophore quenched by an intramolecular nucleophilic mercapto group. carboxylate 67-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 35164223-0 2022 A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE). aryloxyacetic acids 16-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-191 35164223-0 2022 A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE). aryloxyacetic acids 16-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-197 35164231-4 2022 The results showed that acrylamide decreased AChE activity in the examined brain samples by about 25% in comparison to the control group, and this effect was decreased by administering alpha-tocopherol. Acrylamide 24-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 35164231-4 2022 The results showed that acrylamide decreased AChE activity in the examined brain samples by about 25% in comparison to the control group, and this effect was decreased by administering alpha-tocopherol. alpha-Tocopherol 185-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 35203483-8 2022 The hopeaphenol, vitisin A, and vitisin B, showed AChE and monoamine oxidase-B inhibitions in a dose-dependent manner, among which vitisin B and vitisin A exhibited much better activities than those of resveratrol, and had neuroprotective activities against methylglyoxal-induced SH-SY5Y cell deaths. hopeaphenol 4-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 35203483-8 2022 The hopeaphenol, vitisin A, and vitisin B, showed AChE and monoamine oxidase-B inhibitions in a dose-dependent manner, among which vitisin B and vitisin A exhibited much better activities than those of resveratrol, and had neuroprotective activities against methylglyoxal-induced SH-SY5Y cell deaths. vitisin A 17-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 35203483-8 2022 The hopeaphenol, vitisin A, and vitisin B, showed AChE and monoamine oxidase-B inhibitions in a dose-dependent manner, among which vitisin B and vitisin A exhibited much better activities than those of resveratrol, and had neuroprotective activities against methylglyoxal-induced SH-SY5Y cell deaths. malvidin-3-O-glucoside-4 vinyl 32-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 35203483-8 2022 The hopeaphenol, vitisin A, and vitisin B, showed AChE and monoamine oxidase-B inhibitions in a dose-dependent manner, among which vitisin B and vitisin A exhibited much better activities than those of resveratrol, and had neuroprotective activities against methylglyoxal-induced SH-SY5Y cell deaths. malvidin-3-O-glucoside-4 vinyl 131-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 34978797-5 2022 Taking advantage of the sensitive photocurrent response of thiocholine (TCl) on AgNWs/C60-CR, an acetylcholinesterase (AChE)-based PEC biosensing system with tunable detection throughput for the on-site screening of ultratrace organophosphorus pesticides (OPs) was established. organophosphorus 227-243 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 35137748-16 2022 Using virtual docking to the active sites of the human acetylcholinesterase crystal structure, salvianolic acid K, rosmarinic acid and salvianolic acid C showed the best fitting binding modes to active sites of acetylcholinesterase. salvianolic acid K 95-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 35137748-16 2022 Using virtual docking to the active sites of the human acetylcholinesterase crystal structure, salvianolic acid K, rosmarinic acid and salvianolic acid C showed the best fitting binding modes to active sites of acetylcholinesterase. salvianolic acid K 95-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-231 35137748-16 2022 Using virtual docking to the active sites of the human acetylcholinesterase crystal structure, salvianolic acid K, rosmarinic acid and salvianolic acid C showed the best fitting binding modes to active sites of acetylcholinesterase. rosmarinic acid 115-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 35137748-16 2022 Using virtual docking to the active sites of the human acetylcholinesterase crystal structure, salvianolic acid K, rosmarinic acid and salvianolic acid C showed the best fitting binding modes to active sites of acetylcholinesterase. rosmarinic acid 115-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-231 35137748-16 2022 Using virtual docking to the active sites of the human acetylcholinesterase crystal structure, salvianolic acid K, rosmarinic acid and salvianolic acid C showed the best fitting binding modes to active sites of acetylcholinesterase. salvianolic acid C 135-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 2597760-2 1989 It was found out that these peptides, which were fragments of one propeptide beta-LPH were reversible effectors of acetylcholinesterase. propeptide 66-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 34978797-5 2022 Taking advantage of the sensitive photocurrent response of thiocholine (TCl) on AgNWs/C60-CR, an acetylcholinesterase (AChE)-based PEC biosensing system with tunable detection throughput for the on-site screening of ultratrace organophosphorus pesticides (OPs) was established. Thiocholine 59-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 34978797-5 2022 Taking advantage of the sensitive photocurrent response of thiocholine (TCl) on AgNWs/C60-CR, an acetylcholinesterase (AChE)-based PEC biosensing system with tunable detection throughput for the on-site screening of ultratrace organophosphorus pesticides (OPs) was established. Thiocholine 59-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 34978797-5 2022 Taking advantage of the sensitive photocurrent response of thiocholine (TCl) on AgNWs/C60-CR, an acetylcholinesterase (AChE)-based PEC biosensing system with tunable detection throughput for the on-site screening of ultratrace organophosphorus pesticides (OPs) was established. Thiocholine 72-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 34978797-5 2022 Taking advantage of the sensitive photocurrent response of thiocholine (TCl) on AgNWs/C60-CR, an acetylcholinesterase (AChE)-based PEC biosensing system with tunable detection throughput for the on-site screening of ultratrace organophosphorus pesticides (OPs) was established. Thiocholine 72-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 34978797-5 2022 Taking advantage of the sensitive photocurrent response of thiocholine (TCl) on AgNWs/C60-CR, an acetylcholinesterase (AChE)-based PEC biosensing system with tunable detection throughput for the on-site screening of ultratrace organophosphorus pesticides (OPs) was established. organophosphorus 227-243 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 35023196-1 2022 In poisoning with organophosphorus compounds, patients can only profit from the regeneration of acetylcholinesterase, when the poison load has dropped below a toxic level. organophosphorus 18-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 35023196-6 2022 There is no doubt that obidoxime and pralidoxime are able to reactivate OP inhibited AChE activity in poisoned patients thereby increasing AChE activity and contributing substantially to terminate cholinergic crisis. Obidoxime Chloride 23-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 35023196-6 2022 There is no doubt that obidoxime and pralidoxime are able to reactivate OP inhibited AChE activity in poisoned patients thereby increasing AChE activity and contributing substantially to terminate cholinergic crisis. Obidoxime Chloride 23-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 35023196-6 2022 There is no doubt that obidoxime and pralidoxime are able to reactivate OP inhibited AChE activity in poisoned patients thereby increasing AChE activity and contributing substantially to terminate cholinergic crisis. pralidoxime 37-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 35023196-6 2022 There is no doubt that obidoxime and pralidoxime are able to reactivate OP inhibited AChE activity in poisoned patients thereby increasing AChE activity and contributing substantially to terminate cholinergic crisis. pralidoxime 37-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 35053900-0 2022 Inhibitory Mechanism of Baicalein on Acetylcholinesterase: Inhibitory Interaction, Conformational Change, and Computational Simulation. baicalein 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 35053900-4 2022 In the current study, baicalein, a typical bioactive flavonoid, was found to inhibit AChE competitively, with an associated IC50 value of 6.42 +- 0.07 microM, through a monophasic kinetic process. baicalein 22-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 35053900-4 2022 In the current study, baicalein, a typical bioactive flavonoid, was found to inhibit AChE competitively, with an associated IC50 value of 6.42 +- 0.07 microM, through a monophasic kinetic process. Flavonoids 53-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 35053900-5 2022 The AChE fluorescence quenching by baicalein was a static process. baicalein 35-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 35053900-6 2022 The binding constant between baicalein and AChE was an order of magnitude of 104 L mol-1, and hydrogen bonding and hydrophobic interaction were the major forces for forming the baicalein-AChE complex. Hydrogen 94-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 35053900-6 2022 The binding constant between baicalein and AChE was an order of magnitude of 104 L mol-1, and hydrogen bonding and hydrophobic interaction were the major forces for forming the baicalein-AChE complex. Hydrogen 94-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 35053900-8 2022 Molecular docking revealed that baicalein predominated at the active site of AChE, likely tightening the gorge entrance and preventing the substrate from entering and binding with the enzyme, resulting in AChE inhibition. baicalein 32-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 35053900-8 2022 Molecular docking revealed that baicalein predominated at the active site of AChE, likely tightening the gorge entrance and preventing the substrate from entering and binding with the enzyme, resulting in AChE inhibition. baicalein 32-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 205-209 35053900-10 2022 The current study provides an insight into the molecular-level mechanism of baicalein interaction with AChE, which may offer new ideas for the research and development of anti-AD functional foods and drugs. baicalein 76-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 34989015-1 2022 Organophosphorus (OP) insecticide poisoning causes respiratory failure due to acetylcholinesterase (AChE) inhibition. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 34989015-1 2022 Organophosphorus (OP) insecticide poisoning causes respiratory failure due to acetylcholinesterase (AChE) inhibition. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 34989015-2 2022 The AChE reactivating antidote pralidoxime was developed in the 1950s and soon noted to benefit patients occupationally poisoned with the highly potent OP insecticide parathion. pralidoxime 31-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 34989015-2 2022 The AChE reactivating antidote pralidoxime was developed in the 1950s and soon noted to benefit patients occupationally poisoned with the highly potent OP insecticide parathion. Parathion 167-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 35221376-1 2022 In an effort to develop new therapeutic agents to treat Alzheimer"s disease, a series of donepezil-based analogs were designed, synthesized using an environmentally friendly route, and biologically evaluated for their inhibitory activity against electric eel acetylcholinesterase (AChE) enzyme. Donepezil 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 281-285 35221376-2 2022 In vitro studies revealed that the phenyl moiety of donepezil can be successfully replaced with a pyridine ring leading to equally potent inhibitors of electric eel AChE. Donepezil 52-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 35221376-2 2022 In vitro studies revealed that the phenyl moiety of donepezil can be successfully replaced with a pyridine ring leading to equally potent inhibitors of electric eel AChE. pyridine 98-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 35414329-2 2022 Since MnO2 NS can quench the fluorescence of g-C3N4 via the inner-filter effect (IFE), enzymatic hydrolysate (thiocholine, TCh) can efficiently trigger the decomposition of MnO2 nanosheets in the presence of acetylcholinesterase (AChE) and acetylthiocholine (ATCh), resulting in the fluorescence recovery of g-C3N4. Thiocholine 110-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-228 35414329-2 2022 Since MnO2 NS can quench the fluorescence of g-C3N4 via the inner-filter effect (IFE), enzymatic hydrolysate (thiocholine, TCh) can efficiently trigger the decomposition of MnO2 nanosheets in the presence of acetylcholinesterase (AChE) and acetylthiocholine (ATCh), resulting in the fluorescence recovery of g-C3N4. Thiocholine 110-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 230-234 35414329-2 2022 Since MnO2 NS can quench the fluorescence of g-C3N4 via the inner-filter effect (IFE), enzymatic hydrolysate (thiocholine, TCh) can efficiently trigger the decomposition of MnO2 nanosheets in the presence of acetylcholinesterase (AChE) and acetylthiocholine (ATCh), resulting in the fluorescence recovery of g-C3N4. thiocarbohydrazide 123-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-228 35414329-2 2022 Since MnO2 NS can quench the fluorescence of g-C3N4 via the inner-filter effect (IFE), enzymatic hydrolysate (thiocholine, TCh) can efficiently trigger the decomposition of MnO2 nanosheets in the presence of acetylcholinesterase (AChE) and acetylthiocholine (ATCh), resulting in the fluorescence recovery of g-C3N4. thiocarbohydrazide 123-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 230-234 35414329-2 2022 Since MnO2 NS can quench the fluorescence of g-C3N4 via the inner-filter effect (IFE), enzymatic hydrolysate (thiocholine, TCh) can efficiently trigger the decomposition of MnO2 nanosheets in the presence of acetylcholinesterase (AChE) and acetylthiocholine (ATCh), resulting in the fluorescence recovery of g-C3N4. manganese dioxide 173-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-228 35414329-2 2022 Since MnO2 NS can quench the fluorescence of g-C3N4 via the inner-filter effect (IFE), enzymatic hydrolysate (thiocholine, TCh) can efficiently trigger the decomposition of MnO2 nanosheets in the presence of acetylcholinesterase (AChE) and acetylthiocholine (ATCh), resulting in the fluorescence recovery of g-C3N4. manganese dioxide 173-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 230-234 35414329-3 2022 OPs, as inhibitors to AChE activity, can prevent the generation of TCh and decomposition of MnO2 nanosheets while exhibiting fluorescence quenching. OPS 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 35414329-3 2022 OPs, as inhibitors to AChE activity, can prevent the generation of TCh and decomposition of MnO2 nanosheets while exhibiting fluorescence quenching. thiocarbohydrazide 67-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 35414329-3 2022 OPs, as inhibitors to AChE activity, can prevent the generation of TCh and decomposition of MnO2 nanosheets while exhibiting fluorescence quenching. manganese dioxide 92-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 35414329-4 2022 Therefore, the AChE-ATCh-MnO2-g-C3N4 system can be utilized to quantitatively detect OPs based on g-C3N4 fluorescence. c3n4 32-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 35414329-4 2022 Therefore, the AChE-ATCh-MnO2-g-C3N4 system can be utilized to quantitatively detect OPs based on g-C3N4 fluorescence. OPS 85-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 35294755-1 2022 Acetylcholinesterase (AChE) hydrolyzes acetylcholine (ACh), a vital neurotransmitter that regulates muscle movement and brain function, including memory, attention, and learning. Acetylcholine 39-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 35294755-1 2022 Acetylcholinesterase (AChE) hydrolyzes acetylcholine (ACh), a vital neurotransmitter that regulates muscle movement and brain function, including memory, attention, and learning. Acetylcholine 39-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 35294755-1 2022 Acetylcholinesterase (AChE) hydrolyzes acetylcholine (ACh), a vital neurotransmitter that regulates muscle movement and brain function, including memory, attention, and learning. Acetylcholine 54-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 35294755-1 2022 Acetylcholinesterase (AChE) hydrolyzes acetylcholine (ACh), a vital neurotransmitter that regulates muscle movement and brain function, including memory, attention, and learning. Acetylcholine 54-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 35048766-7 2022 Finally, the model was used to predict AChE inhibition by a group of quinazolinones and benzothiadiazine 1,1-dioxides obtained by chemical synthesis, resulting in 14 drug candidates with in silico activity comparable to acetylcholine. Quinazolinones 69-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 35048766-7 2022 Finally, the model was used to predict AChE inhibition by a group of quinazolinones and benzothiadiazine 1,1-dioxides obtained by chemical synthesis, resulting in 14 drug candidates with in silico activity comparable to acetylcholine. benzothiadiazine 1,1-dioxides 88-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 2561349-2 1989 It was revealed, that under conditions promoting DS (hyperpolarization, muscle warming, rise of calcium concentration as well as treatment by the DS--potentiating agent--proadifen) decrease of the postsynaptic membrane sensitivity to the acetylcholine can develop after few multiquantal end-plate currents--and when acetylcholinesterase is inhibited--during the response to a single quantum of acetylcholine. Calcium 96-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 316-336 2561349-2 1989 It was revealed, that under conditions promoting DS (hyperpolarization, muscle warming, rise of calcium concentration as well as treatment by the DS--potentiating agent--proadifen) decrease of the postsynaptic membrane sensitivity to the acetylcholine can develop after few multiquantal end-plate currents--and when acetylcholinesterase is inhibited--during the response to a single quantum of acetylcholine. Proadifen 170-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 316-336 2561349-2 1989 It was revealed, that under conditions promoting DS (hyperpolarization, muscle warming, rise of calcium concentration as well as treatment by the DS--potentiating agent--proadifen) decrease of the postsynaptic membrane sensitivity to the acetylcholine can develop after few multiquantal end-plate currents--and when acetylcholinesterase is inhibited--during the response to a single quantum of acetylcholine. Acetylcholine 238-251 acetylcholinesterase (Cartwright blood group) Homo sapiens 316-336 2602363-1 1989 Intracarotid infusion of 3 microM glycyl-L-glutamine was found to oppose the fall in the choline acetyl-transferase content of the preganglionically denervated cat superior cervical ganglion; this same effect has been demonstrated previously for acetylcholinesterase content. glycylglutamine 34-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 246-266 2534019-1 1989 Hypocrellin A (HA)-sensitized photoinactivation of enzymes in human erythrocyte membrane, including AchE, GPDH, Na(+)-K+ ATPase, Ca2(+)-Mg2+ ATPase were studied in this paper. hypocrellin A 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 2804138-4 1989 The rank order in which ligands stabilized AChE was: edrophonium greater than decamethonium greater than pralidoxime chloride much greater than procainamide. Edrophonium 53-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 2804138-4 1989 The rank order in which ligands stabilized AChE was: edrophonium greater than decamethonium greater than pralidoxime chloride much greater than procainamide. decamethonium 78-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 2804138-4 1989 The rank order in which ligands stabilized AChE was: edrophonium greater than decamethonium greater than pralidoxime chloride much greater than procainamide. pralidoxime 105-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 2804138-4 1989 The rank order in which ligands stabilized AChE was: edrophonium greater than decamethonium greater than pralidoxime chloride much greater than procainamide. Procainamide 144-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 2804138-7 1989 Urea-induced cholinesterase denaturation was also retarded by these ligands. Urea 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-27 2560370-0 1989 [Catalytic properties of acetylcholinesterase, modified by N,N-dimethyl-2-phenylaziridinium. N,N-dimethyl-2-phenylaziridinium 59-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 2560370-2 1989 By means of affinity labelling with N,N-dimethyl-2-phenylaziridinium ion (DPA) two forms of acetylcholinesterase were synthesized that contained one or two molecules of the label covalently attached to the enzyme. N,N-dimethyl-2-phenylaziridinium 36-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 2560370-2 1989 By means of affinity labelling with N,N-dimethyl-2-phenylaziridinium ion (DPA) two forms of acetylcholinesterase were synthesized that contained one or two molecules of the label covalently attached to the enzyme. N,N-dimethyl-2-phenylaziridinium 74-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 2560370-4 1989 It was found that labelling of acetylcholinesterase with one molecule of DPA did not affect the enzyme"s reactivity. N,N-dimethyl-2-phenylaziridinium 73-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 2560370-5 1989 Acetylcholinesterase containing two labels (the second one presumably located at the anionic centre of the enzyme) displayed enhanced and more specific reactivity towards alkane sulfonyl chlorides. alkane sulfonyl chlorides 171-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 35214846-4 2022 In this study, the ethyl-acetate extract (at a concentration of 250 microg/mL) exhibited the greatest inhibitory effect against AChE with significant inhibition of 75%, comparable to the inhibitor galanthamine with an inhibition of 88%. ethyl acetate 19-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 35214846-8 2022 Further, in silico study showed structural binding characterization of rosmarinic acid and carnosic acid with human AChE enzyme. rosmarinic acid 71-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 35214846-8 2022 Further, in silico study showed structural binding characterization of rosmarinic acid and carnosic acid with human AChE enzyme. salvin 91-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 34637829-6 2022 Moreover, chlorpyrifos-induced reductions in heat tolerance (CTmax), acetylcholinesterase (AChE) activity and development time were further magnified by the heat spike. Chlorpyrifos 10-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 34637829-6 2022 Moreover, chlorpyrifos-induced reductions in heat tolerance (CTmax), acetylcholinesterase (AChE) activity and development time were further magnified by the heat spike. Chlorpyrifos 10-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 35367963-10 2022 Furthermore, the fullerene derivatives exhibited antioxidant capacity and reduction of acetylcholinesterase activity. Fullerenes 17-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 35110469-0 2022 Anti-human Glioma Cancer Potentials of Neobavaisoflavone as Natural Antioxidant Compound and Its Inhibition Profiles for Acetylcholinesterase and Butyrylcholinesterase Enzymes with Molecular Modeling and Spin Density Distributions Studies. neobavaisoflavone 39-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 35110469-7 2022 IC50 values were calculated by Neobavaisoflavone diagrams, 63.87 nM for AChE and 112.98 nM for BuChE, % Activity- (Inhibitor). neobavaisoflavone 31-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 2588727-0 1989 [Behavior of serum cholinesterase and acetylcholinesterase activity in acute dimethoate poisoning]. Dimethoate 77-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 2588727-1 1989 With a patient who in suicidal intention had orally taken a larger quantity of Bi 58 EC (dimethoate) especially the behaviour of the serum cholinesterase activity and the whole blood acetylcholinesterase activity was observed over a period of 38 days and it was compared with the clinical appearance. Dimethoate 79-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-203 2588727-1 1989 With a patient who in suicidal intention had orally taken a larger quantity of Bi 58 EC (dimethoate) especially the behaviour of the serum cholinesterase activity and the whole blood acetylcholinesterase activity was observed over a period of 38 days and it was compared with the clinical appearance. Dimethoate 89-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-203 2790449-1 1989 Inhibition of the enzyme, acetylcholinesterase (AChE), at the neuromuscular junction by pyridostigmine (PYR) results in breakdown of the postjunctional folds and dissolution of the Z-discs. Pyridostigmine Bromide 88-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 2790449-1 1989 Inhibition of the enzyme, acetylcholinesterase (AChE), at the neuromuscular junction by pyridostigmine (PYR) results in breakdown of the postjunctional folds and dissolution of the Z-discs. Pyridostigmine Bromide 88-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 2790449-1 1989 Inhibition of the enzyme, acetylcholinesterase (AChE), at the neuromuscular junction by pyridostigmine (PYR) results in breakdown of the postjunctional folds and dissolution of the Z-discs. Pyridostigmine Bromide 104-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 2790449-1 1989 Inhibition of the enzyme, acetylcholinesterase (AChE), at the neuromuscular junction by pyridostigmine (PYR) results in breakdown of the postjunctional folds and dissolution of the Z-discs. Pyridostigmine Bromide 104-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 2528325-8 1989 The Na+ + K+-stimulated Mg2+ ATPase, like the Ca2+ + Mg2+-ATPase, was sensitive to membrane oxidation but the activities of Mg2+-ATPase and acetylcholinesterase were less inhibited by tert-butyl hydroperoxide. tert-Butylhydroperoxide 184-208 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-160 2605685-0 1989 Inhibition of acetylcholinesterase by diastereomers of 2-methylamino-1-phenylpropanol and their derivatives. 2-methylamino-1-phenylpropanol 55-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 2605685-1 1989 The anti-acetylcholinesterase activities of the ephedrine diastereomers and their N-methyl derivatives were correlated to the conformation of the molecules in solution. Ephedrine 48-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 2761299-2 1989 The assay is based upon the reactions: (1) hydrolysis of acetylcholine to choline and acetate, catalyzed by acetylcholinesterase. Acetylcholine 57-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 2573709-1 1989 The inhibition of human and mammalian red blood cell (RBC) cholinesterase (AChE) in whole blood in the presence of added pyridostigmine has been examined. Pyridostigmine Bromide 121-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 2573709-3 1989 An apparent rate constant (ke) was derived for the reaction sequence in which carbamate is released from AChE inhibited by pyridostigmine. Carbamates 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 2573709-3 1989 An apparent rate constant (ke) was derived for the reaction sequence in which carbamate is released from AChE inhibited by pyridostigmine. Pyridostigmine Bromide 123-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 2765560-1 1989 The monoclonal antibody (mAb) AE-2 decreases the rate of hydrolysis of acetylthiocholine (ATC) by fetal bovine serum acetylcholinesterase (acetylcholine acetylhydrolase EC 3.1.1.7) (FBS-AChE) (Doctor, B.P. Acetylthiocholine 71-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 2765560-1 1989 The monoclonal antibody (mAb) AE-2 decreases the rate of hydrolysis of acetylthiocholine (ATC) by fetal bovine serum acetylcholinesterase (acetylcholine acetylhydrolase EC 3.1.1.7) (FBS-AChE) (Doctor, B.P. Acetylthiocholine 71-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 2765560-1 1989 The monoclonal antibody (mAb) AE-2 decreases the rate of hydrolysis of acetylthiocholine (ATC) by fetal bovine serum acetylcholinesterase (acetylcholine acetylhydrolase EC 3.1.1.7) (FBS-AChE) (Doctor, B.P. Acetylthiocholine 90-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 2765560-1 1989 The monoclonal antibody (mAb) AE-2 decreases the rate of hydrolysis of acetylthiocholine (ATC) by fetal bovine serum acetylcholinesterase (acetylcholine acetylhydrolase EC 3.1.1.7) (FBS-AChE) (Doctor, B.P. Acetylthiocholine 90-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 2817369-0 1989 A microassay-based procedure for measuring low levels of toxic organophosphorus compounds through acetylcholinesterase inhibition. organophosphorus 63-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-118 2583490-1 1989 Acetylcholinesterase from human erythrocytes solubilized by 1% Triton X-100 was resolved using polyacrylamide gel electrophoresis into two components. Octoxynol 63-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 2583490-1 1989 Acetylcholinesterase from human erythrocytes solubilized by 1% Triton X-100 was resolved using polyacrylamide gel electrophoresis into two components. polyacrylamide 95-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 2775233-1 1989 The effects of the local anaesthetics procaine, tetracaine and lidocaine and of the antidepressant imipramine on human erythrocyte acetylcholinesterase were investigated. Imipramine 99-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-151 2775233-3 1989 Procaine and tetracaine inhibited acetylcholinesterase activity competitively at concentrations at which they did not perturb the physical state of the membrane lipid environment, as assessed by steady-state fluorescence polarization, whereas lidocaine and imipramine displayed mixed inhibition kinetics at concentrations at which they induced an enhancement of membrane fluidity. Procaine 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 2775233-3 1989 Procaine and tetracaine inhibited acetylcholinesterase activity competitively at concentrations at which they did not perturb the physical state of the membrane lipid environment, as assessed by steady-state fluorescence polarization, whereas lidocaine and imipramine displayed mixed inhibition kinetics at concentrations at which they induced an enhancement of membrane fluidity. Tetracaine 13-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 2605196-0 1989 Inhibition kinetics of acetylcholinesterase with fluoromethyl ketones. fluoromethyl ketones 49-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 2605196-1 1989 A series of trifluoromethyl ketones that reversibly inhibit acetylcholinesterase and pseudocholinesterase were synthesized. trifluoromethyl ketones 12-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 2605196-3 1989 The compound (5,5,5-trifluoro-4-oxopentyl)trimethylammonium bicarbonate (1) inhibits acetylcholinesterase with Ki = 0.06 X 10(-9)M and pseudocholinesterase with Ki = 70 X 10(-9)M. Replacement of the nitrogen of 1 by carbon (compound 2) increases Ki for 1 200-fold for acetylcholinesterase but does not significantly alter Ki for pseudocholinesterase. 5,5,5-trifluoro-4-oxopentyl)trimethylammonium bicarbonate 14-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 2605196-3 1989 The compound (5,5,5-trifluoro-4-oxopentyl)trimethylammonium bicarbonate (1) inhibits acetylcholinesterase with Ki = 0.06 X 10(-9)M and pseudocholinesterase with Ki = 70 X 10(-9)M. Replacement of the nitrogen of 1 by carbon (compound 2) increases Ki for 1 200-fold for acetylcholinesterase but does not significantly alter Ki for pseudocholinesterase. 5,5,5-trifluoro-4-oxopentyl)trimethylammonium bicarbonate 14-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 268-288 2605196-3 1989 The compound (5,5,5-trifluoro-4-oxopentyl)trimethylammonium bicarbonate (1) inhibits acetylcholinesterase with Ki = 0.06 X 10(-9)M and pseudocholinesterase with Ki = 70 X 10(-9)M. Replacement of the nitrogen of 1 by carbon (compound 2) increases Ki for 1 200-fold for acetylcholinesterase but does not significantly alter Ki for pseudocholinesterase. Nitrogen 199-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 2605196-3 1989 The compound (5,5,5-trifluoro-4-oxopentyl)trimethylammonium bicarbonate (1) inhibits acetylcholinesterase with Ki = 0.06 X 10(-9)M and pseudocholinesterase with Ki = 70 X 10(-9)M. Replacement of the nitrogen of 1 by carbon (compound 2) increases Ki for 1 200-fold for acetylcholinesterase but does not significantly alter Ki for pseudocholinesterase. Carbon 62-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 2605196-3 1989 The compound (5,5,5-trifluoro-4-oxopentyl)trimethylammonium bicarbonate (1) inhibits acetylcholinesterase with Ki = 0.06 X 10(-9)M and pseudocholinesterase with Ki = 70 X 10(-9)M. Replacement of the nitrogen of 1 by carbon (compound 2) increases Ki for 1 200-fold for acetylcholinesterase but does not significantly alter Ki for pseudocholinesterase. Carbon 62-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 268-288 2605196-4 1989 The Ki for the methyl ketone corresponding to 2 is 2 X 10(-4)M for both enzymes, as compared with 12 X 10(-9)M for the trifluoromethyl ketone (acetylcholinesterase). Acetone 15-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 2605196-8 1989 The inhibition of acetylcholinesterase by tetramethylammonium chloride and trifluoroacetone was compared to the inhibition by 1, which is a composite of the two smaller inhibitors. tetramethylammonium 42-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 2605196-8 1989 The inhibition of acetylcholinesterase by tetramethylammonium chloride and trifluoroacetone was compared to the inhibition by 1, which is a composite of the two smaller inhibitors. 1,1,1-TRIFLUOROACETONE 75-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 2547925-6 1989 The results of this study have established that acetylcholinesterase associated with unilamellar DMPC liposomes was primarily entrapped within the aqueous compartment of the vesicles and was not present in the phospholipid bilayer. Dimyristoylphosphatidylcholine 97-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 2761299-2 1989 The assay is based upon the reactions: (1) hydrolysis of acetylcholine to choline and acetate, catalyzed by acetylcholinesterase. Choline 63-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 2761299-2 1989 The assay is based upon the reactions: (1) hydrolysis of acetylcholine to choline and acetate, catalyzed by acetylcholinesterase. Acetates 86-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 2474836-14 1989 Azide at 5 mM slowed the initial rate of AchE loss by about 75% with E16 and EYMA. Azides 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 2588333-0 1989 [The effect of ionic strength on reversible inhibition of catalytic activity of acetylcholinesterase by thione phosphonates]. thione phosphonates 104-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 2588333-1 1989 The effect of ionic strength was used to analyze the mechanism of reversible acetylcholinesterase inhibition by three alkoxymethylthionphosphonates. alkoxymethylthionphosphonates 118-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 2568135-1 1989 Evidence has accumulated to implicate neuropeptides localized within midbrain dopamine neurons (cholecystokinin, neurotensin, acetylcholinesterase) in synaptic transmission, mental disease, and pharmacotherapy. Dopamine 78-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 2667712-4 1989 Organophosphorus and carbamate insecticides generate their toxic effects by bonding to and inhibiting ChE enzymes (most importantly, AChE), which are responsible for breaking down the neurotransmitter ACh. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 2667712-4 1989 Organophosphorus and carbamate insecticides generate their toxic effects by bonding to and inhibiting ChE enzymes (most importantly, AChE), which are responsible for breaking down the neurotransmitter ACh. Carbamates 21-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 2474836-18 1989 Deuterium oxide had a positive, but statistically insignificant effect on loss of AchE with both sensitizers. Deuterium Oxide 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 2474836-20 1989 Iodide exerted a modest inhibition of photohemolysis and loss of AchE sensitized by E16, but had virtually no influence on sensitization by EYMA. Iodides 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 2655861-3 1989 Tetrahydroaminoacridine (THA), an acetylcholinesterase inhibitor, is currently being investigated at the McGill Centre for Studies in Aging. Tacrine 0-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 2767140-0 1989 Interaction of quaternary ammonium compounds with acetylcholinesterase: characterization of the active site. Quaternary Ammonium Compounds 15-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 2767140-1 1989 The relation of the structure of 31 quaternary ammonium compounds (28 inhibitors; 3 substrate analogues) with their effects on the activity of acetylcholinesterase (EC 3.1.1.7; AChE) was studied. Quaternary Ammonium Compounds 36-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 2767140-1 1989 The relation of the structure of 31 quaternary ammonium compounds (28 inhibitors; 3 substrate analogues) with their effects on the activity of acetylcholinesterase (EC 3.1.1.7; AChE) was studied. Quaternary Ammonium Compounds 36-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-181 2767140-6 1989 Most of the substances acted as reversible, competitive inhibitors with KI in the range of 10(-6)-10(-3) M. The substrate analogues had Km values between (1.2-2.2) X 10(-4) M. The data allow the following main conclusions: (1) The quaternary trimethylammonium group of ACh is of high importance for substrate binding to AChE. quaternary trimethylammonium 231-259 acetylcholinesterase (Cartwright blood group) Homo sapiens 320-324 2767140-6 1989 Most of the substances acted as reversible, competitive inhibitors with KI in the range of 10(-6)-10(-3) M. The substrate analogues had Km values between (1.2-2.2) X 10(-4) M. The data allow the following main conclusions: (1) The quaternary trimethylammonium group of ACh is of high importance for substrate binding to AChE. Acetylcholine 269-272 acetylcholinesterase (Cartwright blood group) Homo sapiens 320-324 2600828-2 1989 The amplitudes of end-plate currents (EPCs) in short trains of fifteen to seventeen EPCs at 10 Hz were depressed in the presence of 10 microM-proadifen when acetylcholinesterase (AChE) was inhibited. Proadifen 142-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-177 2600828-2 1989 The amplitudes of end-plate currents (EPCs) in short trains of fifteen to seventeen EPCs at 10 Hz were depressed in the presence of 10 microM-proadifen when acetylcholinesterase (AChE) was inhibited. Proadifen 142-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 179-183 2566942-4 1989 Pyridostigmine, an acetylcholinesterase inhibitor, has been postulated as an inhibitor of somatostatin release. Pyridostigmine Bromide 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 2655861-3 1989 Tetrahydroaminoacridine (THA), an acetylcholinesterase inhibitor, is currently being investigated at the McGill Centre for Studies in Aging. Tacrine 25-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 2540962-11 1989 These observations indicate that binding of a single detergent micelle was maintained when any of the three fatty acyl or alkyl groups in the human erythrocyte AChE anchor phospholipid were retained. Phospholipids 172-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 2540962-0 1989 Conversion of human erythrocyte acetylcholinesterase from an amphiphilic to a hydrophilic form by phosphatidylinositol-specific phospholipase C and serum phospholipase D. Phosphatidylinositols 98-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 2540962-1 1989 Each catalytic subunit in the amphiphilic dimer of human erythrocyte acetylcholinesterase (AChE) is anchored in the plasma membrane exclusively by a glycoinositol phospholipid. glycoinositol phospholipid 149-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 2540962-1 1989 Each catalytic subunit in the amphiphilic dimer of human erythrocyte acetylcholinesterase (AChE) is anchored in the plasma membrane exclusively by a glycoinositol phospholipid. glycoinositol phospholipid 149-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 2540962-7 1989 In this report, nondenaturing polyacrylamide gel electrophoresis was applied to permit rapid and unambiguous distinction between amphiphilic AChE, in which each catalytic subunit binds one nonionic detergent micelle, and hydrophilic AChE, which does not interact with detergent. polyacrylamide 30-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 2540962-7 1989 In this report, nondenaturing polyacrylamide gel electrophoresis was applied to permit rapid and unambiguous distinction between amphiphilic AChE, in which each catalytic subunit binds one nonionic detergent micelle, and hydrophilic AChE, which does not interact with detergent. polyacrylamide 30-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-237 2540962-8 1989 Deacylation of human erythrocyte AChE by an alkaline treatment with hydroxylamine rendered the amphiphilic AChE susceptible to PtdIns-specific PLC with the consequent release of hydrophilic AChE. Hydroxylamine 68-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 2540962-8 1989 Deacylation of human erythrocyte AChE by an alkaline treatment with hydroxylamine rendered the amphiphilic AChE susceptible to PtdIns-specific PLC with the consequent release of hydrophilic AChE. Hydroxylamine 68-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 2540962-8 1989 Deacylation of human erythrocyte AChE by an alkaline treatment with hydroxylamine rendered the amphiphilic AChE susceptible to PtdIns-specific PLC with the consequent release of hydrophilic AChE. Hydroxylamine 68-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 2540962-8 1989 Deacylation of human erythrocyte AChE by an alkaline treatment with hydroxylamine rendered the amphiphilic AChE susceptible to PtdIns-specific PLC with the consequent release of hydrophilic AChE. Phosphatidylinositols 127-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 2540962-8 1989 Deacylation of human erythrocyte AChE by an alkaline treatment with hydroxylamine rendered the amphiphilic AChE susceptible to PtdIns-specific PLC with the consequent release of hydrophilic AChE. Phosphatidylinositols 127-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 2540962-8 1989 Deacylation of human erythrocyte AChE by an alkaline treatment with hydroxylamine rendered the amphiphilic AChE susceptible to PtdIns-specific PLC with the consequent release of hydrophilic AChE. Phosphatidylinositols 127-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 2709330-6 1989 N-phenylcarbamoyl eseroline was as potent as benzylcarbamoyl eseroline against AChE yet was 50 to 100 times less potent than the benzyl analog vs. BChE. phenserine 0-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 2709330-6 1989 N-phenylcarbamoyl eseroline was as potent as benzylcarbamoyl eseroline against AChE yet was 50 to 100 times less potent than the benzyl analog vs. BChE. benzylcarbamoyl eseroline 45-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 2709330-7 1989 Therefore, the phenyl substitution appears to increase greatly the selectivity of the compound for AChE. acetophenone 15-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 2749892-0 1989 Regulation of AChE by a dipeptide. Dipeptides 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 2742614-5 1989 It is concluded that tt-conformation of acetylcholine is productive for acetylcholinesterase hydrolysis. Acetylcholine 40-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 2563379-5 1989 We now show that all newly synthesized AChE polypeptides are transported from the rough endoplasmic reticulum to the Golgi apparatus where they acquire N-acetylglucosamine. Acetylglucosamine 152-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 2546574-0 1989 The inhibitory effects of polyoxyethylene detergents on human erythrocyte acetylcholinesterase and Ca2+ + Mg2+ ATPase. Polyethylene Glycols 26-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 2546574-1 1989 The activities of acetylcholinesterase and Ca2+ + Mg2+ ATPase were measured following treatment of human erythrocyte membranes with nonsolubilizing and solubilizing concentrations of Triton X-100. Octoxynol 183-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 2913311-5 1989 The alkynyloxy-substituted compounds were also evaluated in vitro with respect to reversible inhibition of human erythrocyte (RBC) acetylcholinesterase (AChE) and kinetics of reactivation of human AChE inhibited by ethyl p-nitrophenyl methylphosphonate (EPMP). alkynyloxy 4-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 2913311-5 1989 The alkynyloxy-substituted compounds were also evaluated in vitro with respect to reversible inhibition of human erythrocyte (RBC) acetylcholinesterase (AChE) and kinetics of reactivation of human AChE inhibited by ethyl p-nitrophenyl methylphosphonate (EPMP). alkynyloxy 4-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-201 2913311-5 1989 The alkynyloxy-substituted compounds were also evaluated in vitro with respect to reversible inhibition of human erythrocyte (RBC) acetylcholinesterase (AChE) and kinetics of reactivation of human AChE inhibited by ethyl p-nitrophenyl methylphosphonate (EPMP). ethyl p-nitrophenyl methylphosphonate 215-252 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-201 2913311-5 1989 The alkynyloxy-substituted compounds were also evaluated in vitro with respect to reversible inhibition of human erythrocyte (RBC) acetylcholinesterase (AChE) and kinetics of reactivation of human AChE inhibited by ethyl p-nitrophenyl methylphosphonate (EPMP). Ethyl 4-nitrophenyl methylphosphonate 254-258 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-201 2913311-7 1989 For the alkynyloxy-substituted imidazolium drugs there is a direct relationship between in vitro and in vivo activity: the most potent in vivo compounds against GD proved to be potent in vitro reactivators against EPMP-inhibited human AChE. alkynyloxy-substituted imidazolium 8-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 235-239 2773698-0 1989 [Inhibition of acetylcholinesterase at pupil-related central nuclei by organophosphorus pesticide (fenthion)--an experimental study]. organophosphorus 71-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 2773698-0 1989 [Inhibition of acetylcholinesterase at pupil-related central nuclei by organophosphorus pesticide (fenthion)--an experimental study]. Fenthion 99-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 2773698-1 1989 An organophosphorus pesticide (OP) inhibits acetylcholinesterase (AChE) of various organs, especially in cholinergically innervated organs. organophosphorus 3-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 2773698-1 1989 An organophosphorus pesticide (OP) inhibits acetylcholinesterase (AChE) of various organs, especially in cholinergically innervated organs. organophosphorus 3-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 2596267-1 1989 It has been reported recently that some oximes reactivating acetylcholinesterase (AChE) exhibit concomitant ganglion-blocking effects which presumably could contribute independently to their powerful antidotal action in organophosphate inhibitor (OPI) poisoning, thus mimicking some unrelated substances which are effective antidotes without reactivating AChE. Oximes 40-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 2596267-1 1989 It has been reported recently that some oximes reactivating acetylcholinesterase (AChE) exhibit concomitant ganglion-blocking effects which presumably could contribute independently to their powerful antidotal action in organophosphate inhibitor (OPI) poisoning, thus mimicking some unrelated substances which are effective antidotes without reactivating AChE. Oximes 40-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 2596267-1 1989 It has been reported recently that some oximes reactivating acetylcholinesterase (AChE) exhibit concomitant ganglion-blocking effects which presumably could contribute independently to their powerful antidotal action in organophosphate inhibitor (OPI) poisoning, thus mimicking some unrelated substances which are effective antidotes without reactivating AChE. Oximes 40-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 355-359 2596267-1 1989 It has been reported recently that some oximes reactivating acetylcholinesterase (AChE) exhibit concomitant ganglion-blocking effects which presumably could contribute independently to their powerful antidotal action in organophosphate inhibitor (OPI) poisoning, thus mimicking some unrelated substances which are effective antidotes without reactivating AChE. Organophosphates 220-235 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 2596267-1 1989 It has been reported recently that some oximes reactivating acetylcholinesterase (AChE) exhibit concomitant ganglion-blocking effects which presumably could contribute independently to their powerful antidotal action in organophosphate inhibitor (OPI) poisoning, thus mimicking some unrelated substances which are effective antidotes without reactivating AChE. Organophosphates 220-235 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 2596267-1 1989 It has been reported recently that some oximes reactivating acetylcholinesterase (AChE) exhibit concomitant ganglion-blocking effects which presumably could contribute independently to their powerful antidotal action in organophosphate inhibitor (OPI) poisoning, thus mimicking some unrelated substances which are effective antidotes without reactivating AChE. Pantothenyl-Aminoethanol-11-Pivalic Acid 247-250 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 2596267-1 1989 It has been reported recently that some oximes reactivating acetylcholinesterase (AChE) exhibit concomitant ganglion-blocking effects which presumably could contribute independently to their powerful antidotal action in organophosphate inhibitor (OPI) poisoning, thus mimicking some unrelated substances which are effective antidotes without reactivating AChE. Pantothenyl-Aminoethanol-11-Pivalic Acid 247-250 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 2596267-1 1989 It has been reported recently that some oximes reactivating acetylcholinesterase (AChE) exhibit concomitant ganglion-blocking effects which presumably could contribute independently to their powerful antidotal action in organophosphate inhibitor (OPI) poisoning, thus mimicking some unrelated substances which are effective antidotes without reactivating AChE. Pantothenyl-Aminoethanol-11-Pivalic Acid 247-250 acetylcholinesterase (Cartwright blood group) Homo sapiens 355-359 2596267-6 1989 The results show that HI-6 can attenuate lesions only if AChE is partially reactivated and muscle fasciculations are permanently eliminated. asoxime chloride 22-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 2742504-5 1989 On the other hand, in human muscle therapeutic treatment restored only 5%, while prophylactic application of HI-6 again resulted in about 50% recovery of control AChE activity. asoxime chloride 109-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-166 2742504-7 1989 Immediate reactivation of rapidly aging human AChE must therefore be instituted for successful protective treatment by HI-6. asoxime chloride 119-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 2742504-8 1989 Retardation of aging, a direct effect of SAD-128, was roughly estimated to improve reactivation by HI-6 for about 10% of control AChE activity of the human muscle. asoxime chloride 99-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 2776170-1 1989 The presence of acetylcholinesterase (AChE) activity in the adrenal chromaffin cells of Necturus maculosus and Ambystoma maculatum (Amphibia, Urodela) has been demonstrated by cytochemical method at the electron microscope level. chromaffin 68-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 2806119-7 1989 In contrast to muscle actin, AChE was detected in a small proportion of embryos treated with cytochalasin as early as the 1- or 2-cell stage, and most embryos treated with cytochalasin at later cleavages expressed this enzyme in some of their cells. Cytochalasins 93-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 2547555-0 1989 [Post- and presynaptic mechanisms of restoring nerve-muscle transmission with tubocurarine after the effect of an organophosphorous inhibitor of acetylcholinesterase]. Tubocurarine 78-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-166 2547555-0 1989 [Post- and presynaptic mechanisms of restoring nerve-muscle transmission with tubocurarine after the effect of an organophosphorous inhibitor of acetylcholinesterase]. organophosphorous 114-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-166 2709748-0 1989 [Circadian rhythm of blood acetylcholinesterase after administration of organophosphate compounds during hypokinesia]. Organophosphates 72-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 2913485-0 1989 Tacrine protection of acetylcholinesterase from inactivation by diisopropylfluorophosphate: a circular dichroism study. Isoflurophate 64-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 2913485-1 1989 Tacrine (1,2,3,4-tetrahydro-9-aminoacridine) showed an apparent noncompetitive inhibition of Torpedo acetylcholinesterase (AChE) with a dissociation constant, Ki, of 8.5 nM. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 2913485-1 1989 Tacrine (1,2,3,4-tetrahydro-9-aminoacridine) showed an apparent noncompetitive inhibition of Torpedo acetylcholinesterase (AChE) with a dissociation constant, Ki, of 8.5 nM. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 2913485-1 1989 Tacrine (1,2,3,4-tetrahydro-9-aminoacridine) showed an apparent noncompetitive inhibition of Torpedo acetylcholinesterase (AChE) with a dissociation constant, Ki, of 8.5 nM. Tacrine 9-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 2913485-1 1989 Tacrine (1,2,3,4-tetrahydro-9-aminoacridine) showed an apparent noncompetitive inhibition of Torpedo acetylcholinesterase (AChE) with a dissociation constant, Ki, of 8.5 nM. Tacrine 9-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 2913485-3 1989 An extrinsic CD band was induced at 348 nm, with a molar ellipticity of 35,000 deg cm2 dmol-1 (bases on tacrine), when each AChE subunit (Mr = 67,000) was saturated with one tacrine (mol/mol). Cadmium 13-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 2913485-3 1989 An extrinsic CD band was induced at 348 nm, with a molar ellipticity of 35,000 deg cm2 dmol-1 (bases on tacrine), when each AChE subunit (Mr = 67,000) was saturated with one tacrine (mol/mol). Tacrine 104-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 2913485-3 1989 An extrinsic CD band was induced at 348 nm, with a molar ellipticity of 35,000 deg cm2 dmol-1 (bases on tacrine), when each AChE subunit (Mr = 67,000) was saturated with one tacrine (mol/mol). Tacrine 174-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 2913485-4 1989 With this band as a probe, the bound tacrine could be displaced by edrophonium or decamethonium, both of which are known to bind to the anionic site at the active center of AChE, but not by propidium, which binds to the peripheral site of the enzyme. Tacrine 37-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-177 2913485-4 1989 With this band as a probe, the bound tacrine could be displaced by edrophonium or decamethonium, both of which are known to bind to the anionic site at the active center of AChE, but not by propidium, which binds to the peripheral site of the enzyme. Edrophonium 67-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-177 2913485-4 1989 With this band as a probe, the bound tacrine could be displaced by edrophonium or decamethonium, both of which are known to bind to the anionic site at the active center of AChE, but not by propidium, which binds to the peripheral site of the enzyme. decamethonium 82-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-177 2913485-5 1989 Tacrine protected AChE from inactivation by diisopropylfluorophosphate (DFP). Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 2913485-5 1989 Tacrine protected AChE from inactivation by diisopropylfluorophosphate (DFP). Isoflurophate 44-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 2913485-5 1989 Tacrine protected AChE from inactivation by diisopropylfluorophosphate (DFP). Isoflurophate 72-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 2913485-6 1989 AChE completely lost its enzymatic activity when 1 mol of DFP was bound per mol of subunit upon incubation of 7 microM AChE (subunit) with 100 microM DFP for 40 min, but tacrine-treated AChE retained 60% of its activity and bound only 0.2 mol of DFP per mol of subunit under similar conditions. Tacrine 170-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 2913485-7 1989 The corresponding CD, at 348 nm, of the AChE-tacrine-DFP complex increased or decreased gradually, depending on the order of addition of tacrine and DFP, and reached an equilibrium value (80% of its original) after 2 days. Cadmium 18-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 2913485-7 1989 The corresponding CD, at 348 nm, of the AChE-tacrine-DFP complex increased or decreased gradually, depending on the order of addition of tacrine and DFP, and reached an equilibrium value (80% of its original) after 2 days. Tacrine 45-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 2913485-7 1989 The corresponding CD, at 348 nm, of the AChE-tacrine-DFP complex increased or decreased gradually, depending on the order of addition of tacrine and DFP, and reached an equilibrium value (80% of its original) after 2 days. Isoflurophate 53-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 2913485-8 1989 The difference absorption spectrum of the AChE-tacrine-DFP complex was the same as that of the AChE-tacrine complex. Tacrine 47-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 2913485-8 1989 The difference absorption spectrum of the AChE-tacrine-DFP complex was the same as that of the AChE-tacrine complex. Tacrine 47-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 2913485-8 1989 The difference absorption spectrum of the AChE-tacrine-DFP complex was the same as that of the AChE-tacrine complex. Tacrine 100-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 2913485-8 1989 The difference absorption spectrum of the AChE-tacrine-DFP complex was the same as that of the AChE-tacrine complex. Tacrine 100-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 2710346-11 1989 The changes in intensity patterning could reflect changes in acetylcholinesterase metabolism, since postnatal treatment with an irreversible inhibitor (diisofluorophosphate) in vivo demonstrated resynthesis of acetylcholinesterase. diisofluorophosphate 152-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 2710346-11 1989 The changes in intensity patterning could reflect changes in acetylcholinesterase metabolism, since postnatal treatment with an irreversible inhibitor (diisofluorophosphate) in vivo demonstrated resynthesis of acetylcholinesterase. diisofluorophosphate 152-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-230 2666960-4 1989 Because no improvement was seen for 2 weeks, the acetylcholinesterase inhibitors edrophonium and pyridostigmine were instituted. Edrophonium 81-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 2637489-1 1989 The inhibition of soluble human AChE and its molecular forms following the electrophoretic separation in polyacrylamide gel to four in vitro inhibitors was studied. polyacrylamide 105-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 2917983-0 1989 Chiral reactions of acetylcholinesterase probed with enantiomeric methylphosphonothioates. VX 66-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 2917983-2 1989 Enantiomeric cycloheptyl- and isopropyl methylphosphonothioates containing uncharged and cationic leaving groups, and 3,3-dimethylbutyl methylphosphonyl thiocholines were synthesized, and their inhibition of acetylcholinesterase from Torpedo examined. cycloheptyl- and isopropyl methylphosphonothioates 13-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-228 2917983-7 1989 These studies reveal that chiral reactions with acetylcholinesterase are dependent more on the nature of the groups surrounding the tetrahedral phosphorus than on the absolute configuration about the phosphorus atom and indicate that the active center comprises partially overlapping subsites that can accommodate the -OR and -SR" groups. Phosphorus 144-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 2917983-7 1989 These studies reveal that chiral reactions with acetylcholinesterase are dependent more on the nature of the groups surrounding the tetrahedral phosphorus than on the absolute configuration about the phosphorus atom and indicate that the active center comprises partially overlapping subsites that can accommodate the -OR and -SR" groups. Phosphorus 200-210 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 2917984-1 1989 This paper examines the chiral nature of the covalent conjugates formed upon reaction of acetylcholinesterase (AchE) with enantiomeric cycloheptyl, isopropyl, and 3,3-dimethylbutyl methylphosphonyl thiocholines. methylphosphonyl thiocholines 181-210 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 2917984-1 1989 This paper examines the chiral nature of the covalent conjugates formed upon reaction of acetylcholinesterase (AchE) with enantiomeric cycloheptyl, isopropyl, and 3,3-dimethylbutyl methylphosphonyl thiocholines. methylphosphonyl thiocholines 181-210 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 2917984-2 1989 With the exception of the conjugate formed from reaction of AchE with RP-cycloheptyl methylphosphonyl thiocholine, all enantiomeric conjugates underwent oxime reactivation at rates that were within 2-3-fold of each other. cycloheptyl methylphosphonyl thiocholine 73-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 2917984-2 1989 With the exception of the conjugate formed from reaction of AchE with RP-cycloheptyl methylphosphonyl thiocholine, all enantiomeric conjugates underwent oxime reactivation at rates that were within 2-3-fold of each other. Oximes 153-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 2917984-5 1989 Equilibrium titrations with decidium, a fluorescent bisquaternary competitive inhibitor of AchE, provided an index of aging and enantiomeric configuration of the conjugates independent of enzyme activity. decidium 28-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 2917984-8 1989 These studies indicate that the active center of AchE comprises at least two kinetically distinct environments separate from the esteratic region but located within 5 A of the nucleophilic serine and differing in dipolar characteristics that promote charge separation and general acid catalysis. Serine 189-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 2917018-5 1989 HLo-7 is also much more active than HI-6 when used as a reactivator for electric eel AChE inhibited by some N-unsubstituted derivatives of tabun. asoxime chloride 36-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 2917018-5 1989 HLo-7 is also much more active than HI-6 when used as a reactivator for electric eel AChE inhibited by some N-unsubstituted derivatives of tabun. Nitrogen 108-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 2501967-2 1989 Pyridostigmine, an acetylcholinesterase inhibitor, has been shown to augment basal GH secretion and the GH response to GHRH in short children. Pyridostigmine Bromide 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 3226617-5 1988 The carboxypeptidase action of AChE was weakly stimulated by the presence of 100 microM CoCl2 suggesting the requirement of a metal ion for complete activity. cobaltous chloride 88-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 3226617-5 1988 The carboxypeptidase action of AChE was weakly stimulated by the presence of 100 microM CoCl2 suggesting the requirement of a metal ion for complete activity. Metals 126-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 2848806-0 1988 Lipid analysis of the glycoinositol phospholipid membrane anchor of human erythrocyte acetylcholinesterase. glycoinositol phospholipid 22-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 2848806-1 1988 Palmitoylation of inositol results in resistance to phosphatidylinositol-specific phospholipase C. The glycoinositol phospholipid membrane anchor of human erythrocyte acetylcholinesterase (EC 3.1.1.7) contains a novel inositol phospholipid which in this and the accompanying paper (Roberts, W.L., Santikarn, S., Reinhold, V.N., and Rosenberry, T.L. Inositol 18-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-187 2848806-1 1988 Palmitoylation of inositol results in resistance to phosphatidylinositol-specific phospholipase C. The glycoinositol phospholipid membrane anchor of human erythrocyte acetylcholinesterase (EC 3.1.1.7) contains a novel inositol phospholipid which in this and the accompanying paper (Roberts, W.L., Santikarn, S., Reinhold, V.N., and Rosenberry, T.L. Phosphatidylinositols 52-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-187 2848806-1 1988 Palmitoylation of inositol results in resistance to phosphatidylinositol-specific phospholipase C. The glycoinositol phospholipid membrane anchor of human erythrocyte acetylcholinesterase (EC 3.1.1.7) contains a novel inositol phospholipid which in this and the accompanying paper (Roberts, W.L., Santikarn, S., Reinhold, V.N., and Rosenberry, T.L. glycoinositol phospholipid 103-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-187 2848806-1 1988 Palmitoylation of inositol results in resistance to phosphatidylinositol-specific phospholipase C. The glycoinositol phospholipid membrane anchor of human erythrocyte acetylcholinesterase (EC 3.1.1.7) contains a novel inositol phospholipid which in this and the accompanying paper (Roberts, W.L., Santikarn, S., Reinhold, V.N., and Rosenberry, T.L. Phosphatidylinositols 108-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-187 2848806-5 1988 Acidic methanolysis of human erythrocyte acetylcholinesterase (Ehu AChE) revealed 18:0 and 18:1 alkylglycerols (0.55 and 0.20 mol/mol AChE, respectively). alkylglycerols 96-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 2848806-5 1988 Acidic methanolysis of human erythrocyte acetylcholinesterase (Ehu AChE) revealed 18:0 and 18:1 alkylglycerols (0.55 and 0.20 mol/mol AChE, respectively). alkylglycerols 96-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 2848806-6 1988 Acetolysis was shown by TLC to release alkylacylglycerol acetates from Ehu AChE. alkylacylglycerol acetates 39-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 2848806-9 1988 The deamination and acetolysis products from Ehu AChE were purified by high performance liquid chromatography, and fatty acid analysis following acidic methanolysis of the purified products revealed that 2 fatty acid residues were associated with the deamination product and only one with the alkylacylglycerol acetolysis product. Fatty Acids 115-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 2848806-9 1988 The deamination and acetolysis products from Ehu AChE were purified by high performance liquid chromatography, and fatty acid analysis following acidic methanolysis of the purified products revealed that 2 fatty acid residues were associated with the deamination product and only one with the alkylacylglycerol acetolysis product. Fatty Acids 206-216 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 2848806-13 1988 In contrast, digestion of Ehu AChE with a recently reported anchor-specific phospholipase D resulted in release of plasmanic acids from the intact palmitoylated plasmanylinositol. plasmanic acids 115-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 2848806-13 1988 In contrast, digestion of Ehu AChE with a recently reported anchor-specific phospholipase D resulted in release of plasmanic acids from the intact palmitoylated plasmanylinositol. plasmanylinositol 161-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 3196028-1 1988 K 562 cell acetylcholinesterase (AChE), identifiable by active site labeling with radioactive diisopropylfluorophosphate (DFP), showed a Mr around 55,000 in both a crude lysate and a purified sample. Isoflurophate 94-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 3196028-1 1988 K 562 cell acetylcholinesterase (AChE), identifiable by active site labeling with radioactive diisopropylfluorophosphate (DFP), showed a Mr around 55,000 in both a crude lysate and a purified sample. Isoflurophate 94-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 3181125-0 1988 Complex alternative splicing of acetylcholinesterase transcripts in Torpedo electric organ; primary structure of the precursor of the glycolipid-anchored dimeric form. Glycolipids 134-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 3181125-7 1988 Analyses of intact G2a AChE showed that the common domain of the protein contains intersubunit disulphide bonds. disulphide 95-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 3063684-3 1988 The regional effects of AChE inhibition by organophosphates was examined in a comparative study of the brains of two victims and two control brains, matched for age and sex. Organophosphates 43-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 3220975-3 1988 Concurrent histochemical and immunological staining demonstrated that all choline-acetyltransferase-positive NB neurons in the human brain also contain acetylcholinesterase enzyme activity. Choline 74-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 3416009-1 1988 Cytotoxic product(s), which are responsible for inducing the release of acetylcholinesterase-enriched vesicles from human erythrocytes and cell lysis, are generated when 1-saturated-2-polyunsaturated glycerophosphocholine was incubated with oxyhemoglobin (Itabe, H., Kobayashi, T. and Inoue, K. (1988) Biochim. 1-saturated-2-polyunsaturated glycerophosphocholine 170-221 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 2906603-5 1988 Because butyrylthiocholine is the preferred substrate for cholinesterase (EC 3.1.1.8) and acetylthiocholine for acetylcholinesterase (EC 3.1.1.7), these results indicate that bambuterol is a remarkably selective and potent inhibitor of cholinesterase. Acetylthiocholine 90-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 2906603-5 1988 Because butyrylthiocholine is the preferred substrate for cholinesterase (EC 3.1.1.8) and acetylthiocholine for acetylcholinesterase (EC 3.1.1.7), these results indicate that bambuterol is a remarkably selective and potent inhibitor of cholinesterase. bambuterol 175-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 3221239-1 1988 Human erythrocyte acetylcholinesterase (AChE) solubilized with Triton X-100 and obtained as a complex with micelles containing Triton and membrane phospholipids was incubated with immunoglobulins (Igs) from patients with amyotrophic lateral sclerosis (ALS) and from normal individuals. Octoxynol 63-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 3221239-1 1988 Human erythrocyte acetylcholinesterase (AChE) solubilized with Triton X-100 and obtained as a complex with micelles containing Triton and membrane phospholipids was incubated with immunoglobulins (Igs) from patients with amyotrophic lateral sclerosis (ALS) and from normal individuals. Octoxynol 63-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 3221239-1 1988 Human erythrocyte acetylcholinesterase (AChE) solubilized with Triton X-100 and obtained as a complex with micelles containing Triton and membrane phospholipids was incubated with immunoglobulins (Igs) from patients with amyotrophic lateral sclerosis (ALS) and from normal individuals. Phospholipids 147-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 3221239-1 1988 Human erythrocyte acetylcholinesterase (AChE) solubilized with Triton X-100 and obtained as a complex with micelles containing Triton and membrane phospholipids was incubated with immunoglobulins (Igs) from patients with amyotrophic lateral sclerosis (ALS) and from normal individuals. Phospholipids 147-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 3221239-8 1988 At least part of the autoantibodies should be directed against the enzyme molecule, since a change in the Arrhenius plot was also observed in a control experiment with AChE which probably had micelles without any phospholipids. Phospholipids 213-226 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-172 3221239-9 1988 This enzyme was isolated by affinity chromatography and was washed with a buffer containing Triton X-100 before desorption from the affinity column, a treatment known to remove all phospholipids from erythrocyte AChE. Octoxynol 92-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 212-216 3221239-9 1988 This enzyme was isolated by affinity chromatography and was washed with a buffer containing Triton X-100 before desorption from the affinity column, a treatment known to remove all phospholipids from erythrocyte AChE. Phospholipids 181-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 212-216 3078089-0 1988 Enhancement of acetylcholinesterase synthesis by glycyl-L-glutamine: an example of a small peptide that regulates differential transcription? glycylglutamine 49-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 3218137-3 1988 Three isoenzyme forms of acetylcholinesterase, dissimilar in their electrophoretic mobility, were detected in the preparation by ion exchange chromatography on DEAE Sephadex A-50. deae sephadex a 160-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 3185960-3 1988 IC50 values (the concentration required to reduce enzyme activity by 50%) for the inhibition of total tissue AChE were 7.9 x 10(-7) M and 4.5 x 10(-8) M for THA and physostigmine, respectively, and similar values were also obtained for individual molecular forms of AChE (monomer G1, dimer G2 and tetramer G4) separated by sucrose density gradient centrifugation. Tacrine 157-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 3185960-3 1988 IC50 values (the concentration required to reduce enzyme activity by 50%) for the inhibition of total tissue AChE were 7.9 x 10(-7) M and 4.5 x 10(-8) M for THA and physostigmine, respectively, and similar values were also obtained for individual molecular forms of AChE (monomer G1, dimer G2 and tetramer G4) separated by sucrose density gradient centrifugation. Physostigmine 165-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 3185960-3 1988 IC50 values (the concentration required to reduce enzyme activity by 50%) for the inhibition of total tissue AChE were 7.9 x 10(-7) M and 4.5 x 10(-8) M for THA and physostigmine, respectively, and similar values were also obtained for individual molecular forms of AChE (monomer G1, dimer G2 and tetramer G4) separated by sucrose density gradient centrifugation. Sucrose 323-330 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 2773544-2 1989 In connection with other AChE-determination methods for blood quinidine sulphate in a concentration of 2.10(-5) mol/l is used as an inhibitor for the serum-cholinesterase (ChE). Quinidine 62-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 3063684-6 1988 This specific distribution of AChE inhibition may be correlated with some of the clinical characteristics of acute organophosphate poisoning. Organophosphates 115-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 3190453-5 1988 Secondary to edrophonium, diethylparaquat, paraquat, morfamquat and monoquat showed lower I50 for AChE, and possessed higher inhibition selectivity (IS), expressed as the ratio of I50 for BuChE to I50 for erythrocyte AChE. diethylparaquat 26-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 3190453-5 1988 Secondary to edrophonium, diethylparaquat, paraquat, morfamquat and monoquat showed lower I50 for AChE, and possessed higher inhibition selectivity (IS), expressed as the ratio of I50 for BuChE to I50 for erythrocyte AChE. diethylparaquat 26-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 217-221 3190453-7 1988 A negative correlation was observed between log [I50 for erythrocyte AChE] and log [IS], among paraquat and its derivatives, monoquaternary ammoniums and anticholinergic drugs, respectively. Paraquat 95-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 3190453-7 1988 A negative correlation was observed between log [I50 for erythrocyte AChE] and log [IS], among paraquat and its derivatives, monoquaternary ammoniums and anticholinergic drugs, respectively. Ammonium Compounds 140-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 3190453-9 1988 [4] the other type inhibitors showing positive cooperativity for erythrocyte AChE: tetraethylammonium and ethyltrimethylammonium. Tetraethylammonium 83-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 3190453-9 1988 [4] the other type inhibitors showing positive cooperativity for erythrocyte AChE: tetraethylammonium and ethyltrimethylammonium. trimethylethylammonium 106-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 2836034-1 1988 Cultured striatal neurons containing either NADPH-diaphorase or acetylcholinesterase were more resistant to injury by N-methyl-D-aspartate (NMDA) or quinolinate, than the general striatal neuronal population, although this resistance was not absolute and could be overcome by intense toxic exposure. N-Methylaspartate 118-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 3411326-7 1988 Class I contains molecules that aggregate in the absence of detergent, when mixed with an AChE-depleted Triton X-100 extract from electric organ. Octoxynol 104-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 3411326-12 1988 G4a forms of AChE, which are solubilized only in the presence of detergent and aggregate in the absence of detergent, represent a large proportion of cholinesterase in DS extracts of nerves and spinal cord, together with a smaller component of G4a BuChE. ds 168-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 3178859-2 1988 Anesthesia with a barbituric drug, Thiopental, induces an increase in membrane fluidity and a decrease in the activity of acetylcholinesterase in syncytiotrophoblast plasma membranes (SPM) obtained from placentas after caesarean section. Thiopental 35-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 2837347-1 1988 The acetylcholinesterase (EC 3.1.1.7) in 50 microL of a 61-fold dilution of erythrocytes in water hydrolyzes acetylcholine during a timed 20-min reaction at 37 degrees C. The resulting choline is measured by use of choline oxidase coupled to peroxidase, with phenol and aminoantipyrene to give a pink product that absorbs maximally at 500 nm. Phenol 259-265 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 2837347-1 1988 The acetylcholinesterase (EC 3.1.1.7) in 50 microL of a 61-fold dilution of erythrocytes in water hydrolyzes acetylcholine during a timed 20-min reaction at 37 degrees C. The resulting choline is measured by use of choline oxidase coupled to peroxidase, with phenol and aminoantipyrene to give a pink product that absorbs maximally at 500 nm. Ampyrone 270-285 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 3394943-0 1988 Phenyldichlorophosphate as an aid in studies of decarbamylation of carbamylated acetylcholinesterase. phenyl dichlorophosphate 0-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 3394943-2 1988 Acetylcholinesterase was carbamylated with neostigmine and diluted extensively into buffer to allow decarbamylation to occur. Neostigmine 43-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 3394943-3 1988 At various times, phenyldichlorophosphate was added to the mixture of free and carbamylated enzyme, whereupon two very rapid, simultaneous reactions occurred: near total, and permanent, inactivation of free acetylcholinesterase by the organophosphate, and inactivation of phenyldichlorophosphate by hydrolysis. phenyl dichlorophosphate 18-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-227 3394943-3 1988 At various times, phenyldichlorophosphate was added to the mixture of free and carbamylated enzyme, whereupon two very rapid, simultaneous reactions occurred: near total, and permanent, inactivation of free acetylcholinesterase by the organophosphate, and inactivation of phenyldichlorophosphate by hydrolysis. Organophosphates 235-250 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-227 2897731-7 1988 Organophosphorus insecticides owe their acute toxicity to inhibition of acetylcholinesterase and accumulation of acetylcholine at cholinergic receptors. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 2836034-1 1988 Cultured striatal neurons containing either NADPH-diaphorase or acetylcholinesterase were more resistant to injury by N-methyl-D-aspartate (NMDA) or quinolinate, than the general striatal neuronal population, although this resistance was not absolute and could be overcome by intense toxic exposure. Quinolinic Acid 149-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 3166338-8 1988 In our experience, the inhibitor constant (Kl) for edrophonium, which is highly specific for AChE, is approximately 5 x 10(-5) M against adult human erythrocytes that contain significantly more total cholinesterase activity than do erythrocytes from umbilical cord blood. Edrophonium 51-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 3413090-0 1988 Maintenance by glycyl-L-glutamine in vivo of molecular forms of acetylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat. glycylglutamine 15-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 3413090-3 1988 These findings are consistent with the conclusion, drawn from a previous in vitro study, that glycyl-L-glutamine acts at a stage prior to the aggregation of the G1 form into higher polymers to maintain the acetylcholinesterase content of denervated ganglia. glycylglutamine 94-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 206-226 3413090-4 1988 It is proposed that the dipeptide may regulate the transcription of the DNA for acetylcholinesterase to its corresponding mRNA. Dipeptides 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 3391264-1 1988 Reaction of (-)-eseroline (1) with alkyl, aryl and aralkylisocyanates afforded a series of carbamate analogues of (-)-physostigmine (2) which were assayed for inhibition of acetyl- and butyrylcholinesterase (AChE and BChE, respectively) in vitro. eseroline 12-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-212 3391264-1 1988 Reaction of (-)-eseroline (1) with alkyl, aryl and aralkylisocyanates afforded a series of carbamate analogues of (-)-physostigmine (2) which were assayed for inhibition of acetyl- and butyrylcholinesterase (AChE and BChE, respectively) in vitro. alkyl, aryl and aralkylisocyanates 35-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-212 3379413-0 1988 Identification of a trypsin-like site associated with acetylcholinesterase by affinity labelling with [3H]diisopropyl fluorophosphate. [3h]diisopropyl fluorophosphate 102-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 3379413-1 1988 In addition to its ability to hydrolyze acetylcholine, purified eel acetylcholinesterase possesses a trypsin-like endopeptidase activity. Acetylcholine 40-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 3379413-8 1988 The total number of sites labelled by [3H]diisopropyl fluorophosphate on eel acetylcholinesterase was 2.6 mol/280,000 g protein, whereas the number of tryptic sites was less (0.52 mol/280,000 g). [3h]diisopropyl fluorophosphate 38-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 3379413-11 1988 On sodium dodecyl sulfate-polyacrylamide gels, the labelled tryptic component comigrated with a polypeptide of 50,000 molecular weight, which is a major proteolytic digestion product derived from the intact acetylcholinesterase monomer. Sodium Dodecyl Sulfate 3-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-227 2836034-1 1988 Cultured striatal neurons containing either NADPH-diaphorase or acetylcholinesterase were more resistant to injury by N-methyl-D-aspartate (NMDA) or quinolinate, than the general striatal neuronal population, although this resistance was not absolute and could be overcome by intense toxic exposure. N-Methylaspartate 140-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 3258297-2 1988 The presence of 2-mercaptopropionyl glycine (MPG) during irradiation decreased lipid peroxidation and enzyme (acetylcholinesterase, AChE) release. Tiopronin 16-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 3258297-2 1988 The presence of 2-mercaptopropionyl glycine (MPG) during irradiation decreased lipid peroxidation and enzyme (acetylcholinesterase, AChE) release. Tiopronin 16-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 3258297-2 1988 The presence of 2-mercaptopropionyl glycine (MPG) during irradiation decreased lipid peroxidation and enzyme (acetylcholinesterase, AChE) release. Tiopronin 45-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 3258297-2 1988 The presence of 2-mercaptopropionyl glycine (MPG) during irradiation decreased lipid peroxidation and enzyme (acetylcholinesterase, AChE) release. Tiopronin 45-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 3345199-0 1988 Effects of some mono- and bisquaternary ammonium compounds on the reactivatability of soman-inhibited human acetylcholinesterase in vitro. mono- and bisquaternary ammonium 16-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 3338035-4 1988 Tumor serum ChE exhibited elevated sensitivity to 1,5-bis-(4-allyldimethyl ammonium phenyl)-pentan-3-one dibromide (BW), the selective bisquaternary inhibitor of "true" acetylcholinesterase (AChE), with no correlation to age, sex, staging of tumor, presence of metastases or the specific treatment protocol, and with a different distribution pattern from the decrease in ChE specific activity or the sensitivity to iso-OMPA. 1,5-bis-(4-allyldimethyl ammonium phenyl)-pentan-3-one dibromide 50-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 191-195 2451546-3 1988 DAF, AChE, and LAP are known to be anchored within cell membranes to glycophospholipid-containing phosphatidylinositol (PI). glycophospholipid 69-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 2451546-3 1988 DAF, AChE, and LAP are known to be anchored within cell membranes to glycophospholipid-containing phosphatidylinositol (PI). Phosphatidylinositols 98-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 3164041-1 1988 The activity was measured of the acetylcholine catabolising enzyme acetylcholinesterase (AChE) in brain after necropsy of seven patients from one established pedigree with dominantly-inherited olivopontocerebellar atrophy (OPCA), a cerebellar ataxia disorder in which neuropathological changes are assumed to be primarily restricted to cerebellum, lower brain stem and spinal cord. Acetylcholine 33-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 3376122-1 1988 The regional distribution of AChE inhibition by parathion in the human brain was examined in a comparative study of the brains of 2 victims of lethal parathion intoxication and 2 control brains matched for age and sex. Parathion 48-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 3376122-3 1988 The inhibition of human brain AChE by parathion is regionally selective. Parathion 38-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 3345199-1 1988 Acetylcholinesterase (AChE) inhibited by the organophosphate soman (1,2,2-trimethyl-propylmethylphosphonofluoridate) rapidly becomes resistant to reactivation by oximes due to dealkylation of the soman-enzyme complex. Soman 68-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 3345199-1 1988 Acetylcholinesterase (AChE) inhibited by the organophosphate soman (1,2,2-trimethyl-propylmethylphosphonofluoridate) rapidly becomes resistant to reactivation by oximes due to dealkylation of the soman-enzyme complex. Soman 68-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 3345199-1 1988 Acetylcholinesterase (AChE) inhibited by the organophosphate soman (1,2,2-trimethyl-propylmethylphosphonofluoridate) rapidly becomes resistant to reactivation by oximes due to dealkylation of the soman-enzyme complex. Oximes 162-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 3345199-1 1988 Acetylcholinesterase (AChE) inhibited by the organophosphate soman (1,2,2-trimethyl-propylmethylphosphonofluoridate) rapidly becomes resistant to reactivation by oximes due to dealkylation of the soman-enzyme complex. Oximes 162-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 3345199-9 1988 All effectors increased the AChE reactivatability by HI 6 when added before aging was started. asoxime chloride 53-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 3345207-0 1988 Ketamine protects acetylcholinesterase against in vitro inhibition by sarin. Ketamine 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 3422756-0 1988 Effects of glycyl-L-glutamine in vitro on the molecular forms of acetylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat. glycylglutamine 11-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 3422756-2 1988 They were then homogenized, and the molecular forms of acetylcholinesterase were analyzed by sucrose gradient sedimentation. Sucrose 93-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 3422756-3 1988 We observed an increased proportion of the globular monomeric G1 form, and to a lesser extent of the dimeric G2 and tetrameric membranous G4 forms, of acetylcholinesterase in the glycyl-L-glutamine-treated compared with the control cultures. glycylglutamine 179-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-171 3422756-5 1988 It therefore seems likely that glycyl-L-glutamine, or the endogenous neurotrophic factor, maintains acetylcholinesterase in the preganglionically denervated ganglia in vivo by specifically increasing the biosynthesis of the monomeric G1 form, but not that of other proteins; these trophic factors do not seem to promote the polymerization of G1 into the more complex G2 and G4 forms. glycylglutamine 31-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 3345199-1 1988 Acetylcholinesterase (AChE) inhibited by the organophosphate soman (1,2,2-trimethyl-propylmethylphosphonofluoridate) rapidly becomes resistant to reactivation by oximes due to dealkylation of the soman-enzyme complex. organophosphate soman 45-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 3345199-1 1988 Acetylcholinesterase (AChE) inhibited by the organophosphate soman (1,2,2-trimethyl-propylmethylphosphonofluoridate) rapidly becomes resistant to reactivation by oximes due to dealkylation of the soman-enzyme complex. organophosphate soman 45-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 20702349-1 1988 The effects of toluene, trichloroethylene and ethanol on membrane acetylcholinesterase (AChE) activity in human and rat intact erythrocytes and erythrocyte ghosts were studied in vitro over a range of concentrations (300-3000 ppm) and at three different incubation temperatures (37, 15 and 5 degrees C). Ethanol 46-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 3421136-0 1988 Effects of pralidoxime applied locally into the midbrain reticular formation on the hippocampal theta rhythm induced by acetylcholinesterase inhibition. pralidoxime 11-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 3421136-1 1988 After local administration into the midbrain reticular formation of an acetylcholinesterase reactivator--Pralidoxime, a significant decrease of intensity of hippocampal theta rhythm induced by previous inhibition of acetylcholinesterase by DFP was observed already after 10 min. pralidoxime 105-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 3421136-1 1988 After local administration into the midbrain reticular formation of an acetylcholinesterase reactivator--Pralidoxime, a significant decrease of intensity of hippocampal theta rhythm induced by previous inhibition of acetylcholinesterase by DFP was observed already after 10 min. pralidoxime 105-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 216-236 2449534-6 1988 NTE and AChE inhibition were 70% and 55%, respectively, 24 h after the last treatment, for the chicks treated with DBL. desbromoleptophos 115-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-12 20501292-2 1988 In the (C) fraction, tailed asymmetric 16S AChE required high salt conditions to be extracted, while in (A) and (S) microsomal membranes, a collagenase sensitive 16S form, was extracted by detergent alone. Salts 62-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 3188768-1 1988 L-DOPA effects on the activities of enzymes controlling the neurotransmitters utilization: monoamine oxidases (MAO) A and B and acetylcholinesterase (AChE) were demonstrated in synaptosomes and mitochondria of the cells in sensorimotor cortex and caudate nucleus. Levodopa 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 3188768-2 1988 Sixty minutes after a single dose of L-DOPA the MAO and AChE activities were virtually unchanged in subfractions of both brain regions. Levodopa 37-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 3691807-1 1987 It is shown that the salt effect in acetylcholinesterase-catalyzed hydrolysis of 2-(N-methylmorpholinium)-ethylacetate can be quantitatively described by the equation log(k2/KS) = log(k2/KS) degrees--psi log[M+Z] following from Manning"s polyelectrolyte theory; the psi values for salts with univalent and bivalent cations at different pH values of the reaction medium were in accordance with the conclusions of the theory. Salts 21-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 3691807-1 1987 It is shown that the salt effect in acetylcholinesterase-catalyzed hydrolysis of 2-(N-methylmorpholinium)-ethylacetate can be quantitatively described by the equation log(k2/KS) = log(k2/KS) degrees--psi log[M+Z] following from Manning"s polyelectrolyte theory; the psi values for salts with univalent and bivalent cations at different pH values of the reaction medium were in accordance with the conclusions of the theory. 2-(N-methylmorpholinium)ethyl acetate 81-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 3691807-1 1987 It is shown that the salt effect in acetylcholinesterase-catalyzed hydrolysis of 2-(N-methylmorpholinium)-ethylacetate can be quantitatively described by the equation log(k2/KS) = log(k2/KS) degrees--psi log[M+Z] following from Manning"s polyelectrolyte theory; the psi values for salts with univalent and bivalent cations at different pH values of the reaction medium were in accordance with the conclusions of the theory. Potassium 174-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 3377438-3 1988 In the DAT and EDAT groups, CSF AChE activities (mean +/- SD = 17.5 +/- 3.6 and 15.3 +/- 4.4 nmol/min/ml, respectively) were significantly lower (p less than 0.05) than in 13 age-matched control subjects (21.5 +/- 5.6 nmol/min/ml). edat 15-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 2848549-1 1988 Peripheral-type benzodiazepine binding of [3H]Ro5-4864 at one, non-saturating concentration and activities of choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) were measured in 7 cortical areas from postmortem brains of 18 patients with Alzheimer disease (AD), 12 age-matched controls, and 15 miscellaneous neurological cases. Benzodiazepines 16-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 2848549-1 1988 Peripheral-type benzodiazepine binding of [3H]Ro5-4864 at one, non-saturating concentration and activities of choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) were measured in 7 cortical areas from postmortem brains of 18 patients with Alzheimer disease (AD), 12 age-matched controls, and 15 miscellaneous neurological cases. Benzodiazepines 16-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 3337547-1 1988 Water-induced activation of acetylcholinesterase. Water 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 3337547-5 1988 In AP and polycythemia rubra vera after water exposure a significantly increased AChE activity suggesting acetylcholine release was observed, whereas in the patient with cold urticaria and the controls, a significant decrease was noted. Water 40-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 3337547-5 1988 In AP and polycythemia rubra vera after water exposure a significantly increased AChE activity suggesting acetylcholine release was observed, whereas in the patient with cold urticaria and the controls, a significant decrease was noted. Acetylcholine 106-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 3215481-2 1988 The responsiveness of dystrophic avian muscle to acetylcholine may be altered due to reported elevated acetylcholinesterase activity. Acetylcholine 49-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 3229626-2 1988 Rabbit serum was shown to contain two cholinesterases which hydrolysed acetylthiocholine and butyrylthiocholine and one cholinesterase which hydrolysed only butyrylthiocholine. Acetylthiocholine 71-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-52 3229626-2 1988 Rabbit serum was shown to contain two cholinesterases which hydrolysed acetylthiocholine and butyrylthiocholine and one cholinesterase which hydrolysed only butyrylthiocholine. Butyrylthiocholine 93-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-52 3229626-6 1988 Using selective inhibitors (iso-OMPA, eserine, BNPP and BW-284C51) it was shown that the hydrolysis of acetylthiocholine and butyrylthiocholine in untreated native serum had properties of acetylcholinesterase (EC 3.1.1.7), butyrylcholinesterase (EC 3.1.1.8) and also some properties of carboxylesterase (EC 3.1.1.1). Acetylthiocholine 103-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-208 3229626-6 1988 Using selective inhibitors (iso-OMPA, eserine, BNPP and BW-284C51) it was shown that the hydrolysis of acetylthiocholine and butyrylthiocholine in untreated native serum had properties of acetylcholinesterase (EC 3.1.1.7), butyrylcholinesterase (EC 3.1.1.8) and also some properties of carboxylesterase (EC 3.1.1.1). Butyrylthiocholine 125-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-208 3229626-12 1988 The fastest moving band hydrolysing only butyrylthiocholine could be attributed to the cholinesterase least sensitive to VX. Butyrylthiocholine 41-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-101 3434205-4 1987 Increased concentrations of 3-methoxytyramine (3-MT), homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HI-AA) and increased activity of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in lumbar cerebrospinal fluid was found in patients with acute brain infarction when compared to control values, while the levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) were not altered. Methoxyhydroxyphenylglycol 337-368 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 3434205-4 1987 Increased concentrations of 3-methoxytyramine (3-MT), homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HI-AA) and increased activity of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in lumbar cerebrospinal fluid was found in patients with acute brain infarction when compared to control values, while the levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) were not altered. Methoxyhydroxyphenylglycol 370-374 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 2445915-0 1987 An immunoglobulin M monoclonal antibody, recognizing a subset of acetylcholinesterase molecules from electric organs of Electrophorus and Torpedo, belongs to the HNK-1 anti-carbohydrate family. Carbohydrates 173-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 20702349-1 1988 The effects of toluene, trichloroethylene and ethanol on membrane acetylcholinesterase (AChE) activity in human and rat intact erythrocytes and erythrocyte ghosts were studied in vitro over a range of concentrations (300-3000 ppm) and at three different incubation temperatures (37, 15 and 5 degrees C). Ethanol 46-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 20702349-2 1988 Toluene and trichloroethylene decreased the AChE activity in intact erythrocytes and in erythrocyte ghosts in both species. Toluene 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 20702349-2 1988 Toluene and trichloroethylene decreased the AChE activity in intact erythrocytes and in erythrocyte ghosts in both species. Trichloroethylene 12-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 20702349-4 1988 At low concentrations, toluene generally had greater AChE-inhibiting potency than trichloroethylene. Toluene 23-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 3694255-3 1987 The effects of acetylcholine (ACh), the muscarinic antagonist scopolamine (Sco), the nicotinic antagonist dihydro-beta-erythroidine (DBE), and the acetylcholinesterase inhibitor physostigmine (Phy) on maintained and light-evoked ganglion cell discharge was examined using iontophoresis techniques. Physostigmine 178-191 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 3434781-2 1987 This method permits use of an enzyme-linked immunosorbent assay plate reader for rapid analysis of multiple samples and is particularly suitable for analysis of acetylcholinesterase activity on sucrose gradients. Sucrose 194-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-181 3685073-3 1987 A rate-decreasing dose of physostigmine, an acetylcholinesterase inhibitor, was studied in combination with the range of atropine doses. Physostigmine 26-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 3657387-1 1987 The membrane-bound acetylcholinesterase (AchE) from human peripheral blood lymphocyte gives only one symmetrical peak on sucrose density gradient centrifugation in the presence of Triton X-100 detergent, with the calculated sedimentation coefficient of 6.5 S. However, this dimeric form of AchE was converted to a monomeric 3.8 S form when treated with 2-mercaptoethanol and iodoacetic acid. Sucrose 121-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 3657387-1 1987 The membrane-bound acetylcholinesterase (AchE) from human peripheral blood lymphocyte gives only one symmetrical peak on sucrose density gradient centrifugation in the presence of Triton X-100 detergent, with the calculated sedimentation coefficient of 6.5 S. However, this dimeric form of AchE was converted to a monomeric 3.8 S form when treated with 2-mercaptoethanol and iodoacetic acid. Octoxynol 180-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 3657387-1 1987 The membrane-bound acetylcholinesterase (AchE) from human peripheral blood lymphocyte gives only one symmetrical peak on sucrose density gradient centrifugation in the presence of Triton X-100 detergent, with the calculated sedimentation coefficient of 6.5 S. However, this dimeric form of AchE was converted to a monomeric 3.8 S form when treated with 2-mercaptoethanol and iodoacetic acid. Mercaptoethanol 353-370 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 3657387-1 1987 The membrane-bound acetylcholinesterase (AchE) from human peripheral blood lymphocyte gives only one symmetrical peak on sucrose density gradient centrifugation in the presence of Triton X-100 detergent, with the calculated sedimentation coefficient of 6.5 S. However, this dimeric form of AchE was converted to a monomeric 3.8 S form when treated with 2-mercaptoethanol and iodoacetic acid. Iodoacetic Acid 375-390 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 3657387-4 1987 Polyacrylamide gel electrophoresis indicated a single band with AchE activity in the presence of Triton X-100. polyacrylamide 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 3657387-4 1987 Polyacrylamide gel electrophoresis indicated a single band with AchE activity in the presence of Triton X-100. Octoxynol 97-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 3426523-1 1987 Right atrial biopsies from rat and human hearts were studied using combined methods for the demonstration of glyoxylic acid-induced fluorescence (GIF) of catecholamines and acetylcholinesterase (AChE) reactions in the same specimens. glyoxylic acid 109-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 3499586-6 1987 The AChE activity of lymphocytes may thus be a useful marker to follow the alterations in the metabolism of acetylcholine (ACh) in the central nervous system (CNS) of different types of dementia. Acetylcholine 108-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 3651530-1 1987 Acetylcholinesterase (AChE) from erythrocytes was solubilized by Triton X-100. Octoxynol 65-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 3651530-1 1987 Acetylcholinesterase (AChE) from erythrocytes was solubilized by Triton X-100. Octoxynol 65-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 3651530-2 1987 Size and charge heterogeneity of AChE was investigated by polyacrylamide gel electrophoresis (PAGE) and isoelectric focusing (IEF) in polyacrylamide gels in the presence of 0.5% (v/v) Triton X-100. polyacrylamide 58-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 3651530-2 1987 Size and charge heterogeneity of AChE was investigated by polyacrylamide gel electrophoresis (PAGE) and isoelectric focusing (IEF) in polyacrylamide gels in the presence of 0.5% (v/v) Triton X-100. polyacrylamide 134-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 3651530-2 1987 Size and charge heterogeneity of AChE was investigated by polyacrylamide gel electrophoresis (PAGE) and isoelectric focusing (IEF) in polyacrylamide gels in the presence of 0.5% (v/v) Triton X-100. Octoxynol 184-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 2887244-2 1987 Comparison of TH-lir with adjacent sections stained for acetylcholinesterase (AChE) activity showed that TH-lir is confined to the AChE-rich matrix compartment. th-lir 105-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 3298548-2 1987 A radiometric assay for human AChE utilized a specific monoclonal AChE antibody adsorbed to polystyrene microtiter wells at alkaline pH. Polystyrenes 92-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 3298548-2 1987 A radiometric assay for human AChE utilized a specific monoclonal AChE antibody adsorbed to polystyrene microtiter wells at alkaline pH. Polystyrenes 92-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 3603322-2 1987 The type of poisoning which inhibits acetylcholinesterase (AChE) most often encountered in an intensive care unit is that of organophosphates (OP). Organophosphates 125-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 3603322-2 1987 The type of poisoning which inhibits acetylcholinesterase (AChE) most often encountered in an intensive care unit is that of organophosphates (OP). Organophosphates 125-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 3603322-3 1987 Carbamates also inhibit AChE but for a much shorter duration and they do not cause the same degree of central nervous system effects as OP. Carbamates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 3607051-1 1987 Release of acetylcholinesterase-containing vesicles from human erythrocyte membranes induced by dimyristoylphosphatidylcholine (DMPC) was inhibited by exposure of red cells to cationic amphiphilic drugs like tetracaine, chlorpromazine and primaquine which all are known to induce stomatocyte formation. Dimyristoylphosphatidylcholine 96-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 3607051-1 1987 Release of acetylcholinesterase-containing vesicles from human erythrocyte membranes induced by dimyristoylphosphatidylcholine (DMPC) was inhibited by exposure of red cells to cationic amphiphilic drugs like tetracaine, chlorpromazine and primaquine which all are known to induce stomatocyte formation. Dimyristoylphosphatidylcholine 128-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 3607051-1 1987 Release of acetylcholinesterase-containing vesicles from human erythrocyte membranes induced by dimyristoylphosphatidylcholine (DMPC) was inhibited by exposure of red cells to cationic amphiphilic drugs like tetracaine, chlorpromazine and primaquine which all are known to induce stomatocyte formation. Tetracaine 208-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 3607051-1 1987 Release of acetylcholinesterase-containing vesicles from human erythrocyte membranes induced by dimyristoylphosphatidylcholine (DMPC) was inhibited by exposure of red cells to cationic amphiphilic drugs like tetracaine, chlorpromazine and primaquine which all are known to induce stomatocyte formation. Chlorpromazine 220-234 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 3607051-1 1987 Release of acetylcholinesterase-containing vesicles from human erythrocyte membranes induced by dimyristoylphosphatidylcholine (DMPC) was inhibited by exposure of red cells to cationic amphiphilic drugs like tetracaine, chlorpromazine and primaquine which all are known to induce stomatocyte formation. Primaquine 239-249 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 2887244-2 1987 Comparison of TH-lir with adjacent sections stained for acetylcholinesterase (AChE) activity showed that TH-lir is confined to the AChE-rich matrix compartment. th-lir 105-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 2887244-2 1987 Comparison of TH-lir with adjacent sections stained for acetylcholinesterase (AChE) activity showed that TH-lir is confined to the AChE-rich matrix compartment. th-lir 105-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 2887244-3 1987 TH-lir persists within the matrix zone, which is reduced in Huntington"s disease (HD), suggesting that the nigrostriatal AChE projection may contribute to the persistent AChE patch-matrix pattern in HD. th-lir 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 2887244-3 1987 TH-lir persists within the matrix zone, which is reduced in Huntington"s disease (HD), suggesting that the nigrostriatal AChE projection may contribute to the persistent AChE patch-matrix pattern in HD. th-lir 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 3323058-2 1987 Acetylcholine induced glucose uptake can be predictably potentiated by inhibiting acetylcholinesterase activity. Acetylcholine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 3323058-2 1987 Acetylcholine induced glucose uptake can be predictably potentiated by inhibiting acetylcholinesterase activity. Glucose 22-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 3323058-3 1987 Monocrotophos, acothione (organophosphorus compound) and prostigmine are known inhibitors of acetylcholinesterase (AChE). acothione 15-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 3323058-3 1987 Monocrotophos, acothione (organophosphorus compound) and prostigmine are known inhibitors of acetylcholinesterase (AChE). acothione 15-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 3323058-3 1987 Monocrotophos, acothione (organophosphorus compound) and prostigmine are known inhibitors of acetylcholinesterase (AChE). organophosphorus 26-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 3323058-3 1987 Monocrotophos, acothione (organophosphorus compound) and prostigmine are known inhibitors of acetylcholinesterase (AChE). organophosphorus 26-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 3323058-3 1987 Monocrotophos, acothione (organophosphorus compound) and prostigmine are known inhibitors of acetylcholinesterase (AChE). Neostigmine 57-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 3323058-3 1987 Monocrotophos, acothione (organophosphorus compound) and prostigmine are known inhibitors of acetylcholinesterase (AChE). Neostigmine 57-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 3323058-4 1987 In the present study the action of these three inhibitors of AChE alone as well as in combination with insulin and acetylcholine on in vitro glucose uptake by pigeon liver slices was investigated. Glucose 141-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 3575379-1 1987 A series of analogues of physostigmine were prepared with the aim of investigating their inhibitory effects on acetylcholinesterase in the treatment of Alzheimer"s disease. Physostigmine 25-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 3566286-1 1987 The aim of the work was to elucidate the role of water in the reaction between acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) and methanesulfonyl fluoride, accelerated by accelerators. Water 49-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 3566286-1 1987 The aim of the work was to elucidate the role of water in the reaction between acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) and methanesulfonyl fluoride, accelerated by accelerators. methanesulfonyl fluoride 142-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 3566286-6 1987 These findings, together with others, led to the following model of the role of hydration water in acylation of acetylcholinesterase. Water 90-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 3607514-6 1987 Furthermore, TPA- and RA-treated cells showed a significant increase in acetylcholinesterase activity compared with non-treated cells. Tetradecanoylphorbol Acetate 13-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 3607514-6 1987 Furthermore, TPA- and RA-treated cells showed a significant increase in acetylcholinesterase activity compared with non-treated cells. Tretinoin 22-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 3607514-8 1987 These findings demonstrate that TPA and RA can regulate both the number of muscarinic receptors and the acetylcholinesterase activity in human SH-SY5Y neuroblastoma cells. Tetradecanoylphorbol Acetate 32-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 3607514-8 1987 These findings demonstrate that TPA and RA can regulate both the number of muscarinic receptors and the acetylcholinesterase activity in human SH-SY5Y neuroblastoma cells. Tretinoin 40-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 3652114-13 1987 Power spectra obtained after the application of inhibitors of acetylcholinesterase (AChE), with or without curare, suggested that acetylcholine (ACh) does not accumulate during large depolarizations. Acetylcholine 62-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 3652114-13 1987 Power spectra obtained after the application of inhibitors of acetylcholinesterase (AChE), with or without curare, suggested that acetylcholine (ACh) does not accumulate during large depolarizations. Acetylcholine 84-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 3572402-3 1987 Therefore in the present study we have examined the distribution of the individual molecular forms of both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in plasma and CSF using sucrose density gradient centrifugation. Sucrose 192-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 3306451-6 1987 Acetylcholinesterase more slowly cleaved the C-terminal alanine residue from the peptide to yield LWMRF. Alanine 56-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 3306451-11 1987 These results show that acetylcholinesterase can hydrolyse peptides like a trypsin-like endopeptidase and a Zn2+- or Co2+-dependent exopeptidase, and they suggest that these two peptidase activities are associated with two separate active sites on the acetylcholinesterase molecule. Zinc 108-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 3306451-11 1987 These results show that acetylcholinesterase can hydrolyse peptides like a trypsin-like endopeptidase and a Zn2+- or Co2+-dependent exopeptidase, and they suggest that these two peptidase activities are associated with two separate active sites on the acetylcholinesterase molecule. Zinc 108-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 252-272 3306451-11 1987 These results show that acetylcholinesterase can hydrolyse peptides like a trypsin-like endopeptidase and a Zn2+- or Co2+-dependent exopeptidase, and they suggest that these two peptidase activities are associated with two separate active sites on the acetylcholinesterase molecule. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 117-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 3306451-11 1987 These results show that acetylcholinesterase can hydrolyse peptides like a trypsin-like endopeptidase and a Zn2+- or Co2+-dependent exopeptidase, and they suggest that these two peptidase activities are associated with two separate active sites on the acetylcholinesterase molecule. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 117-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 252-272 3472250-5 1987 It was determined that the light signals are not due to the spontaneous hydrolysis of acetylcholine or the presence of free choline, but are caused by the enzymatic action of AcChoEase. Acetylcholine 86-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 175-184 3593210-0 1987 Removal of covalently bound inositol from Torpedo acetylcholinesterase and mammalian alkaline phosphatases by deamination with nitrous acid. Inositol 28-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 3580004-0 1987 [Mechanism of the reaction of N,N-dimethyl-2-phenylaziridinium with acetylcholinesterase in its active site]. N,N-dimethyl-2-phenylaziridinium 30-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 3580004-1 1987 Effect of temperature on the rate of the bond-breaking step of acetylcholinesterase modification with N,N-dimethylaziridinium ion was studied within 8 to 45 degrees C temperature interval. n,n-dimethylaziridinium 102-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 3580004-2 1987 For this reaction measured by irreversible inhibition of the acetylcholinesterase-catalyzed hydrolysis of acetylthiocholine the activation parameters delta H not equal to = 94 kJ/mole and delta S not equal to (25 degrees C) = -9.4 J/mol X deg were obtained. Acetylthiocholine 106-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 3593210-0 1987 Removal of covalently bound inositol from Torpedo acetylcholinesterase and mammalian alkaline phosphatases by deamination with nitrous acid. Nitrous Acid 127-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 3593210-2 1987 Our earlier evidence suggested that both acetylcholinesterase and alkaline phosphatase are anchored to the cell surface via covalently-attached phosphatidylinositol [Low, Futerman, Ferguson & Silman (1986) Trends Biochem. Phosphatidylinositols 144-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 3477301-0 1987 Characterization of "fetal-type" acetylcholinesterase in hemin-treated K562 cell culture. Hemin 57-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 3477301-1 1987 The alteration of acetylcholinesterase (ACHE) activity, a marker enzyme of erythroid differentiation, was studied during the hemin-induced erythroid differentiation of K562 human leukemia cells in suspension culture. Hemin 125-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 3477301-1 1987 The alteration of acetylcholinesterase (ACHE) activity, a marker enzyme of erythroid differentiation, was studied during the hemin-induced erythroid differentiation of K562 human leukemia cells in suspension culture. Hemin 125-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 3477301-5 1987 These data indicate that ACHE activity is an earlier and more sensitive marker for hemin-induced erythroid differentiation of K562 cells than is elevated Hb content. Hemin 83-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 3477301-6 1987 Electrophoretic mobility of ACHE from hemin-treated cells proved to be the fetal type, but after incubation with neuraminidase, the rate of migration decreased to the level of the adult type enzyme. Hemin 38-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 3666098-4 1987 The anomalous 2-DG uptake was not due to enhanced cortico-geniculate or other visual input to layer A, but instead appears related to a marked increase in acetylcholinesterase activity in this layer following the early chiasm section. Deoxyglucose 14-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-175 2439699-6 1987 NTE and AChE inhibition were around 80 and 50%, respectively, 24 h after treatment, for the chicks treated with DBL. desbromoleptophos 112-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-12 20501161-6 1987 We describe here at least two distinct AChE pools, according to their differential solubility in non-ionic detergent and high-salt media. Salts 126-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 3778942-1 1986 Acetylcholinesterase activity was assayed in the absence and presence of pyridoxal 5"-phosphate. Pyridoxal Phosphate 73-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 3098245-2 1986 The present paper evaluates the interaction of aprophen with acetylcholinesterases, butyrylcholinesterases, and carboxylesterases with respect to protecting the enzyme from organophosphate and carbamate inhibition, accelerating pralidoxime iodide (2-PAM) regeneration of the diisopropylphospho-enzyme, and comparing the inhibition and regeneration kinetics of a soluble mammalian acetylcholinesterase with that of bovine erythrocyte acetylcholinesterase. Organophosphates 173-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 3098245-2 1986 The present paper evaluates the interaction of aprophen with acetylcholinesterases, butyrylcholinesterases, and carboxylesterases with respect to protecting the enzyme from organophosphate and carbamate inhibition, accelerating pralidoxime iodide (2-PAM) regeneration of the diisopropylphospho-enzyme, and comparing the inhibition and regeneration kinetics of a soluble mammalian acetylcholinesterase with that of bovine erythrocyte acetylcholinesterase. Carbamates 193-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 3098245-2 1986 The present paper evaluates the interaction of aprophen with acetylcholinesterases, butyrylcholinesterases, and carboxylesterases with respect to protecting the enzyme from organophosphate and carbamate inhibition, accelerating pralidoxime iodide (2-PAM) regeneration of the diisopropylphospho-enzyme, and comparing the inhibition and regeneration kinetics of a soluble mammalian acetylcholinesterase with that of bovine erythrocyte acetylcholinesterase. pralidoxime 228-246 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 3098245-2 1986 The present paper evaluates the interaction of aprophen with acetylcholinesterases, butyrylcholinesterases, and carboxylesterases with respect to protecting the enzyme from organophosphate and carbamate inhibition, accelerating pralidoxime iodide (2-PAM) regeneration of the diisopropylphospho-enzyme, and comparing the inhibition and regeneration kinetics of a soluble mammalian acetylcholinesterase with that of bovine erythrocyte acetylcholinesterase. diisopropylphospho 275-293 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 3098245-3 1986 The irreversible inhibition kinetics of diisopropyl fluorophosphate (DFP) and eserine inhibition of fetal bovine serum acetylcholinesterase were typical of other acetylcholinesterases as indicated by the bimolecular inhibition rate constants, ki, of 7.7 +/- 1.3 X 10(4) M-1 min-1 and 2.9 +/- 1.7 X 10(6) M-1 min-1, respectively. Isoflurophate 40-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 3827594-1 1986 HI 6 has been shown to be efficacious in soman intoxication of laboratory animals by reactivation of acetylcholinesterase. asoxime chloride 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 2432921-8 1986 Our findings indicate that DAF and AChE are anchored in Ehu by the same or a similar glycolipid structure and that, like VSGs, this structure is incorporated into DAF early in DAF biosynthesis prior to processing of pro-DAF in the Golgi. Glycolipids 85-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 3803759-2 1986 The interaction of soman, a mixture of four stereoisomers designated as C(+)P(-), C(-)P(-), C(+)P(+), and C(-)P(+), with cyclodextrins was revealed by methods based on the irreversible inhibition of acetylcholinesterase (AChE) that is phosphonylated chiefly by P(-)-isomers of racemic soman and continuous titration of fluoride ions released by soman using a fluoride-specific electrode. Cyclodextrins 121-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-219 3803759-2 1986 The interaction of soman, a mixture of four stereoisomers designated as C(+)P(-), C(-)P(-), C(+)P(+), and C(-)P(+), with cyclodextrins was revealed by methods based on the irreversible inhibition of acetylcholinesterase (AChE) that is phosphonylated chiefly by P(-)-isomers of racemic soman and continuous titration of fluoride ions released by soman using a fluoride-specific electrode. Cyclodextrins 121-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 221-225 3803759-7 1986 The cleavage of P(-)-soman by beta-cyclodextrin as estimated by AChE inhibition proceeds apparently at the same rate for the C(-)P(-)-and C(+)P(-)-isomers. betadex 30-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 3783578-2 1986 3(5)-Substituted 1,2,4-oxadiazol-5(3)-aldoximes and 1,2,4-oxadiazole-5(3)-thiocarbohydroximates as reactivators of organophosphonate-inhibited eel and human acetylcholinesterase in vitro. 1,2,4-oxadiazole-5(3)-thiocarbohydroximates 66-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-191 3783578-2 1986 3(5)-Substituted 1,2,4-oxadiazol-5(3)-aldoximes and 1,2,4-oxadiazole-5(3)-thiocarbohydroximates as reactivators of organophosphonate-inhibited eel and human acetylcholinesterase in vitro. Organophosphonates 129-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-191 3768408-0 1986 Inactivation of acetylcholinesterase with a bretylium tosylate photoaffinity probe. bretylium 44-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 3768408-3 1986 Acetylcholinesterase was used as a model protein, and both bretylium and ABT are reversible inhibitors of this enzyme. bretylium 59-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 3768408-3 1986 Acetylcholinesterase was used as a model protein, and both bretylium and ABT are reversible inhibitors of this enzyme. abt 73-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 3768408-8 1986 Since ABT binds at or near the acetylcholinesterase active site, it may be a useful probe for the characterization of the enzyme active site. abt 6-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 3778956-1 1986 Effect of 4,4-dyisotiocyanostilben-2,2-disulfonate (DIDS) and 1-ftor-2,4-dinitrobenzol (NDFB) on the rate of phosphate ion transport in erythrocytes, filtrability and thermal stability of erythrocytes and on the structural state of the erythrocyte membrane estimated by UV-fluorescence, PAAG--electrophoresis and measuring of the activity of membrane-bound acetylcholinesterase (AChE) has been studied. Phosphates 109-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 379-383 3801037-1 1986 In order to determine whether catalytic hydrolysis of acetylcholine, observed in muscle microsomes enriched in sarcoplasmic reticulum membranes, was carried out by true acetylcholinesterase we studied the substrate specificity of this enzyme, its kinetic behaviour and its sensitivity against several reversible inhibitors. Acetylcholine 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-189 3764913-1 1986 Human erythrocytes were exposed to different concentrations of aromatic hydrocarbons, chlorinated aliphatic hydrocarbons, and alcohols in vitro to study the effects of these agents on the activity of acetylcholinesterase (AchE), a membrane integral protein. Alcohols 126-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-220 3764913-2 1986 Aromatic hydrocarbons were in general more potent AchE inhibitors than chlorinated aliphatic hydrocarbons and alcohols at +37 degrees C. The influence of decreasing the temperature to +15 degrees C and +5 degrees C was more prominent on the effect of aromatic hydrocarbons than on the effect of chlorinated aliphatic hydrocarbons and alcohols. Hydrocarbons, Aromatic 0-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 3746817-7 1986 The in vitro reactivation potency of the alpha-keto thiohydroximates approaches and even surpasses that of 2-PAM and toxogonin for GD-inhibited AChE. alpha-keto thiohydroximates 41-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 3746817-7 1986 The in vitro reactivation potency of the alpha-keto thiohydroximates approaches and even surpasses that of 2-PAM and toxogonin for GD-inhibited AChE. pralidoxime 107-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 3778956-2 1986 Unpenetrating anion transport inhibitor DIDS is shown to induce structural modifications of bands 3 of protein and AChE, while DNFB penetrating the membrane causes a significant reorganization of many membrane proteins (including spectrin) resulting in changes of transport and mechanical properties of erythrocytes. 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid 40-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 3760912-1 1986 Acetylcholinesterase (AChE) in the cerebrospinal fluid (CSF) from patients with Alzheimer-type dementia and control subjects was analyzed by centrifugation on a sucrose density gradient, and by column chromatography on Sephadex G-200. Sucrose 161-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 3760912-1 1986 Acetylcholinesterase (AChE) in the cerebrospinal fluid (CSF) from patients with Alzheimer-type dementia and control subjects was analyzed by centrifugation on a sucrose density gradient, and by column chromatography on Sephadex G-200. sephadex 219-233 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 3089281-0 1986 Kinetic, equilibrium and spectroscopic studies on cation association at the active center of acetylcholinesterase: topographic distinction between trimethyl and trimethylammonium sites. trimethyl 147-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 3746817-2 1986 Dialkylaminoalkyl thioesters of alpha-keto thiohydroximic acids as reactivators of ethyl methylphosphonyl- and 1,2,2-trimethylpropyl methylphosphonyl-acetylcholinesterase in vitro. dialkylaminoalkyl thioesters 0-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 3746817-2 1986 Dialkylaminoalkyl thioesters of alpha-keto thiohydroximic acids as reactivators of ethyl methylphosphonyl- and 1,2,2-trimethylpropyl methylphosphonyl-acetylcholinesterase in vitro. alpha-keto thiohydroximic acids 32-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 3746817-3 1986 In the search for improved lipophilic centrally active acetylcholinesterase (AChE) antidotes, a series of alpha-keto thiohydroximates were prepared and evaluated for their ability to reactivate AChEs inhibited by ethyl p-nitrophenyl methylphosphonate (EPMP) and soman (GD). alpha-keto thiohydroximates 106-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 3746817-3 1986 In the search for improved lipophilic centrally active acetylcholinesterase (AChE) antidotes, a series of alpha-keto thiohydroximates were prepared and evaluated for their ability to reactivate AChEs inhibited by ethyl p-nitrophenyl methylphosphonate (EPMP) and soman (GD). alpha-keto thiohydroximates 106-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 3746817-5 1986 In this series, varying R substituents on the aryl ring produced compounds with oxime pKa values from 6.8 to 8.0, optimum for an AChE reactivator. Oximes 80-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 3746817-6 1986 Increasing lipophilicity of the amine segment correlated with reactivator potency, as did electron-withdrawing groups on the aryl moiety, presumably due to increased binding to hydrophobic sites surrounding the AChE active site. Amines 32-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-215 3089281-0 1986 Kinetic, equilibrium and spectroscopic studies on cation association at the active center of acetylcholinesterase: topographic distinction between trimethyl and trimethylammonium sites. Cetrimonium 161-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 3729986-1 1986 The binding of D-tubocurarine (TC) to acetylcholinesterase (AChE) was studied using different methods of enzyme kinetics. Tubocurarine 15-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 3729986-1 1986 The binding of D-tubocurarine (TC) to acetylcholinesterase (AChE) was studied using different methods of enzyme kinetics. Tubocurarine 31-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 3729986-3 1986 TC reversibly inhibits the hydrolysis of different substrates of AChE with three different inhibition constants (Ki1 = 7.0 +/- 0.8 X 10(-5) M, Ki2 = 3.1 +/- 1.0 X 10(-4) M, and Ki3 = 4.2 +/- 0.5 X 10(-3) M). Tubocurarine 0-2 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 3729986-5 1986 These three inhibitors compete with TC in the inhibition of enzymatic hydrolysis of acetylthiocholine (ASCh); all three of them affect the noncompetitive component of the inhibition of the hydrolysis of ASCh by TC, which arises from the binding of TC to the peripheral anionic site of AChE, but TEA and C-10 affect also the competitive component of this inhibition, which arises from the binding of TC at the catalytic anionic site. Acetylthiocholine 84-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 285-289 3729986-5 1986 These three inhibitors compete with TC in the inhibition of enzymatic hydrolysis of acetylthiocholine (ASCh); all three of them affect the noncompetitive component of the inhibition of the hydrolysis of ASCh by TC, which arises from the binding of TC to the peripheral anionic site of AChE, but TEA and C-10 affect also the competitive component of this inhibition, which arises from the binding of TC at the catalytic anionic site. asch 103-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 285-289 3729986-5 1986 These three inhibitors compete with TC in the inhibition of enzymatic hydrolysis of acetylthiocholine (ASCh); all three of them affect the noncompetitive component of the inhibition of the hydrolysis of ASCh by TC, which arises from the binding of TC to the peripheral anionic site of AChE, but TEA and C-10 affect also the competitive component of this inhibition, which arises from the binding of TC at the catalytic anionic site. asch 203-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 285-289 3729986-5 1986 These three inhibitors compete with TC in the inhibition of enzymatic hydrolysis of acetylthiocholine (ASCh); all three of them affect the noncompetitive component of the inhibition of the hydrolysis of ASCh by TC, which arises from the binding of TC to the peripheral anionic site of AChE, but TEA and C-10 affect also the competitive component of this inhibition, which arises from the binding of TC at the catalytic anionic site. Tubocurarine 211-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 285-289 3729986-5 1986 These three inhibitors compete with TC in the inhibition of enzymatic hydrolysis of acetylthiocholine (ASCh); all three of them affect the noncompetitive component of the inhibition of the hydrolysis of ASCh by TC, which arises from the binding of TC to the peripheral anionic site of AChE, but TEA and C-10 affect also the competitive component of this inhibition, which arises from the binding of TC at the catalytic anionic site. Tubocurarine 211-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 285-289 3729986-5 1986 These three inhibitors compete with TC in the inhibition of enzymatic hydrolysis of acetylthiocholine (ASCh); all three of them affect the noncompetitive component of the inhibition of the hydrolysis of ASCh by TC, which arises from the binding of TC to the peripheral anionic site of AChE, but TEA and C-10 affect also the competitive component of this inhibition, which arises from the binding of TC at the catalytic anionic site. Tubocurarine 211-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 285-289 3729986-6 1986 TC partially inhibits the methanesulfonylation of AChE; dissociation constant for TC in this process is KA = 4.5 X 10(-4) M. All our results lead to the conclusion that TC binds to three regions on the active surface of AChE. Tubocurarine 0-2 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 3729986-6 1986 TC partially inhibits the methanesulfonylation of AChE; dissociation constant for TC in this process is KA = 4.5 X 10(-4) M. All our results lead to the conclusion that TC binds to three regions on the active surface of AChE. Tubocurarine 0-2 acetylcholinesterase (Cartwright blood group) Homo sapiens 220-224 3729986-6 1986 TC partially inhibits the methanesulfonylation of AChE; dissociation constant for TC in this process is KA = 4.5 X 10(-4) M. All our results lead to the conclusion that TC binds to three regions on the active surface of AChE. Tubocurarine 82-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 3729986-6 1986 TC partially inhibits the methanesulfonylation of AChE; dissociation constant for TC in this process is KA = 4.5 X 10(-4) M. All our results lead to the conclusion that TC binds to three regions on the active surface of AChE. Tubocurarine 82-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 220-224 3729986-6 1986 TC partially inhibits the methanesulfonylation of AChE; dissociation constant for TC in this process is KA = 4.5 X 10(-4) M. All our results lead to the conclusion that TC binds to three regions on the active surface of AChE. Tubocurarine 82-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 3729986-6 1986 TC partially inhibits the methanesulfonylation of AChE; dissociation constant for TC in this process is KA = 4.5 X 10(-4) M. All our results lead to the conclusion that TC binds to three regions on the active surface of AChE. Tubocurarine 82-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 220-224 3719368-1 1986 When all of the AChE at the endplate is irreversibly inhibited by phospholine iodide the ionophoretically induced ACh endplate currents are increased more than 10-fold in amplitude. Echothiophate Iodide 66-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 3767274-0 1986 Effect of ethanol on erythrocyte acetylcholinesterase activity. Ethanol 10-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 3767274-3 1986 In vitro experiments showed that ethanol inhibited the AchE activity immediately and in proportion to the concentration of ethanol used. Ethanol 33-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 3767274-3 1986 In vitro experiments showed that ethanol inhibited the AchE activity immediately and in proportion to the concentration of ethanol used. Ethanol 123-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 3767274-5 1986 Incubation of normal red cells with ethanol for 15 h, followed by washing, showed also that AchE activity was inhibited by the previous exposure to ethanol and that washing did not reduce the inhibitory effect. Ethanol 36-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 3767274-5 1986 Incubation of normal red cells with ethanol for 15 h, followed by washing, showed also that AchE activity was inhibited by the previous exposure to ethanol and that washing did not reduce the inhibitory effect. Ethanol 148-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 3732039-0 1986 [Specificity of interaction with acetylcholinesterase and butyrylcholinesterase of choline analogs based on ephedrine and pseudoephedrine]. Ephedrine 108-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 3732039-0 1986 [Specificity of interaction with acetylcholinesterase and butyrylcholinesterase of choline analogs based on ephedrine and pseudoephedrine]. Pseudoephedrine 122-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 3524746-0 1986 Acetylcholinesterase generates enkephalin-like immunoreactivity when it degrades the soluble proteins (chromogranins) from adrenal chromaffin granules. chromaffin 131-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 3524746-3 1986 The purified AChE degraded the chromogranins, the soluble proteins from the adrenal chromaffin granules, at a rate of nearly 8 micrograms/microgram AChE/h. chromaffin 84-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 3017385-0 1986 Photoinactivation of acetylcholinesterase by erythrosin B and related compounds. Erythrosine 45-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 3746817-7 1986 The in vitro reactivation potency of the alpha-keto thiohydroximates approaches and even surpasses that of 2-PAM and toxogonin for GD-inhibited AChE. Gadolinium 131-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 3730831-3 1986 These effects suggest two mechanisms of action of these compounds: (a) inhibition of acetylcholinesterase at low doses, which increases the effective ACh dose, and (b) direct antagonism of the response at higher concentrations, which is associated with a slowing of both the activation and desensitization of the ACh response. Acetylcholine 150-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 3719368-2 1986 The reversible AChE inhibitor pyridostigmine only increases the current to about half this value because its effects are obscured by receptor blocking. Pyridostigmine Bromide 30-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 2874096-3 1986 The potency of inhibitory activity of H2-antagonists on acetylcholinesterase estimated from median inhibitory dose were in the following order of decreasing activity: ranitidine greater than TZU-0460 greater than cimetidine greater than YM-11170, whereas that on pseudocholinesterase were TZU-0460 greater than ranitidine greater than cimetidine greater than YM-11170. Hydrogen 38-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 2874096-3 1986 The potency of inhibitory activity of H2-antagonists on acetylcholinesterase estimated from median inhibitory dose were in the following order of decreasing activity: ranitidine greater than TZU-0460 greater than cimetidine greater than YM-11170, whereas that on pseudocholinesterase were TZU-0460 greater than ranitidine greater than cimetidine greater than YM-11170. Ranitidine 311-321 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 2874096-3 1986 The potency of inhibitory activity of H2-antagonists on acetylcholinesterase estimated from median inhibitory dose were in the following order of decreasing activity: ranitidine greater than TZU-0460 greater than cimetidine greater than YM-11170, whereas that on pseudocholinesterase were TZU-0460 greater than ranitidine greater than cimetidine greater than YM-11170. Ranitidine 167-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 2874096-3 1986 The potency of inhibitory activity of H2-antagonists on acetylcholinesterase estimated from median inhibitory dose were in the following order of decreasing activity: ranitidine greater than TZU-0460 greater than cimetidine greater than YM-11170, whereas that on pseudocholinesterase were TZU-0460 greater than ranitidine greater than cimetidine greater than YM-11170. TZU 0460 191-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 2874096-3 1986 The potency of inhibitory activity of H2-antagonists on acetylcholinesterase estimated from median inhibitory dose were in the following order of decreasing activity: ranitidine greater than TZU-0460 greater than cimetidine greater than YM-11170, whereas that on pseudocholinesterase were TZU-0460 greater than ranitidine greater than cimetidine greater than YM-11170. Cimetidine 213-223 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 2874096-3 1986 The potency of inhibitory activity of H2-antagonists on acetylcholinesterase estimated from median inhibitory dose were in the following order of decreasing activity: ranitidine greater than TZU-0460 greater than cimetidine greater than YM-11170, whereas that on pseudocholinesterase were TZU-0460 greater than ranitidine greater than cimetidine greater than YM-11170. Famotidine 237-245 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 2874096-3 1986 The potency of inhibitory activity of H2-antagonists on acetylcholinesterase estimated from median inhibitory dose were in the following order of decreasing activity: ranitidine greater than TZU-0460 greater than cimetidine greater than YM-11170, whereas that on pseudocholinesterase were TZU-0460 greater than ranitidine greater than cimetidine greater than YM-11170. TZU 0460 289-297 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 3717952-1 1986 The theory of noncompetitive inhibition of acetylcholinesterase based on the binding of inhibitor to the acetylenzyme and the free enzyme was proven correct by demonstrating that tripropylammonium ion increases the steady-state concentration of acetylenzyme, as predicted by the theory. tripropylammonium 179-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 2874096-3 1986 The potency of inhibitory activity of H2-antagonists on acetylcholinesterase estimated from median inhibitory dose were in the following order of decreasing activity: ranitidine greater than TZU-0460 greater than cimetidine greater than YM-11170, whereas that on pseudocholinesterase were TZU-0460 greater than ranitidine greater than cimetidine greater than YM-11170. Cimetidine 335-345 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 2874096-3 1986 The potency of inhibitory activity of H2-antagonists on acetylcholinesterase estimated from median inhibitory dose were in the following order of decreasing activity: ranitidine greater than TZU-0460 greater than cimetidine greater than YM-11170, whereas that on pseudocholinesterase were TZU-0460 greater than ranitidine greater than cimetidine greater than YM-11170. Famotidine 359-367 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 3942870-3 1986 The decrease in AChE activity was correlated with a decrease in choline acetyltransferase activity thought to reflect lesion of cholinergic neurones in the substantia innominata which innervate the cerebral cortex. Choline 64-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 2422055-4 1986 From these results we conclude that the glycophospholipid anchors of protozoan VSG and of AChE of the two vertebrates share common structural features, suggesting that this novel type of membrane anchor has been conserved during evolution. glycophospholipid 40-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 3699334-0 1986 Kinetic studies and structure-activity relationships of bispyridinium oximes as reactivators of acetylcholinesterase inhibited by organophosphorus compounds. bispyridinium oximes 56-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 3699334-0 1986 Kinetic studies and structure-activity relationships of bispyridinium oximes as reactivators of acetylcholinesterase inhibited by organophosphorus compounds. Organophosphorus Compounds 130-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 3699334-1 1986 The kinetics of the reactivation of acetylcholinesterase inhibited by isopropyl methylphosphonofluoridate was studied. Sarin 70-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 3954783-3 1986 The rates of inhibition of AChE by these phosphylated oximes and the parent (and related) organophosphates have also been measured. Oximes 54-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 3954784-1 1986 On the formation of O,O-diethyl phosphorylated AChE and O-ethyl methylphosphonylated AChE and their reactivation by PS2. O,O-DIETHYL 20-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 3954784-1 1986 On the formation of O,O-diethyl phosphorylated AChE and O-ethyl methylphosphonylated AChE and their reactivation by PS2. O,O-DIETHYL 20-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 3954784-2 1986 The in vitro reactivation profiles of O,O-diethyl phosphorylated AChE and O-ethyl methyl phosphonylated AChE by P2S (2-hydroxy iminomethyl-1-methyl-pyridinium methane sulphonate) have been determined. o-ethyl methyl phosphonylated 74-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 3954784-2 1986 The in vitro reactivation profiles of O,O-diethyl phosphorylated AChE and O-ethyl methyl phosphonylated AChE by P2S (2-hydroxy iminomethyl-1-methyl-pyridinium methane sulphonate) have been determined. P-2 112-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 3954784-2 1986 The in vitro reactivation profiles of O,O-diethyl phosphorylated AChE and O-ethyl methyl phosphonylated AChE by P2S (2-hydroxy iminomethyl-1-methyl-pyridinium methane sulphonate) have been determined. P-2 112-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 3954784-2 1986 The in vitro reactivation profiles of O,O-diethyl phosphorylated AChE and O-ethyl methyl phosphonylated AChE by P2S (2-hydroxy iminomethyl-1-methyl-pyridinium methane sulphonate) have been determined. 2-hydroxy iminomethyl-1-methyl-pyridinium methane sulphonate 117-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 3954784-5 1986 In the case of O,O-diethyl phosphorylated AChE the main kinetic difference between these two species is found not in the formation or stability of the phosphorylated AChE-P2S complex but in its subsequent reaction. O,O-DIETHYL 15-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 3954784-5 1986 In the case of O,O-diethyl phosphorylated AChE the main kinetic difference between these two species is found not in the formation or stability of the phosphorylated AChE-P2S complex but in its subsequent reaction. O,O-DIETHYL 15-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 3954784-6 1986 From results with O-ethyl methylphosphonylated AChE prepared from two pairs of enantiomers as well as from the racemic fluoridate it was concluded that phosphonylation of AChE may not always occur via a mechanism involving inversion of configuration at phosphorus but can also occur with retention of configuration. fluoridate 119-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 3954784-6 1986 From results with O-ethyl methylphosphonylated AChE prepared from two pairs of enantiomers as well as from the racemic fluoridate it was concluded that phosphonylation of AChE may not always occur via a mechanism involving inversion of configuration at phosphorus but can also occur with retention of configuration. Phosphorus 253-263 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 3954784-7 1986 Reactivation by P2S of O-ethyl methylphosphonylated AChE prepared from (S) organophosphates proceeds with inversion of configuration at phosphorus. Organophosphates 71-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 3719620-9 1986 These were mostly "true" acetylcholinesterase (EC 3.1.1.7) activities, inhibited by 10(-5) M BW284C51, with minor pseudocholinesterase (EC 3.1.1.8) activities, inhibited by 10(-5) M iso-OMPA. Tetraisopropylpyrophosphamide 182-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 3705200-1 1986 Alkyl tributylphosphonium and triphenylphosphonium derivatives as well as tetraphenylphosphonium were first studied as inhibitors of acetylcholinesterase of human blood erythrocytes and butyrylcholinesterase of horse blood serum. alkyl tributylphosphonium 0-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 3705200-1 1986 Alkyl tributylphosphonium and triphenylphosphonium derivatives as well as tetraphenylphosphonium were first studied as inhibitors of acetylcholinesterase of human blood erythrocytes and butyrylcholinesterase of horse blood serum. 3-(bromopropyl)triphenylphosphonium 30-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 3705200-1 1986 Alkyl tributylphosphonium and triphenylphosphonium derivatives as well as tetraphenylphosphonium were first studied as inhibitors of acetylcholinesterase of human blood erythrocytes and butyrylcholinesterase of horse blood serum. tetraphenylphosphonium 74-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 3716682-1 1986 Studies have been made on the reversible inhibition of acetylcholinesterase activity from the erythrocytes of man, horse and camel, the electric organ of the skate Torpedo marmorata and eel Electrophorus electricus, the venom of the snakes Naja naja and Vipera lebetina, the brain of the pigeon Columba livia by tetraphenyl-, triphenylalkyl- and tributyrylalkyl-phosphonium salts. phosphonium salts 362-379 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 3716682-2 1986 The investigated phosphonium inhibitors exhibit an evident specificity in their action: they were more effective in inhibiting the acetylcholinesterase from human erythrocytes than that from the erythrocytes of horse and camel. Phosphoranes 17-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-151 3954930-4 1986 The difference in the time-course of responses to acetylcholine and carbachol may be attributed to differences in the susceptibility of the two drugs to metabolism by acetylcholinesterase; carbachol, unlike acetylcholine, being virtually immune to metabolism by this enzyme. Acetylcholine 50-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-187 3954930-4 1986 The difference in the time-course of responses to acetylcholine and carbachol may be attributed to differences in the susceptibility of the two drugs to metabolism by acetylcholinesterase; carbachol, unlike acetylcholine, being virtually immune to metabolism by this enzyme. Carbachol 68-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-187 3954930-4 1986 The difference in the time-course of responses to acetylcholine and carbachol may be attributed to differences in the susceptibility of the two drugs to metabolism by acetylcholinesterase; carbachol, unlike acetylcholine, being virtually immune to metabolism by this enzyme. Carbachol 189-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-187 3091003-7 1986 Under sub-optimal glucose concentrations or in the absence of treatment of the synaptosomes with the acetylcholinesterase inhibitor phospholine, the incorporation of radioactivity exceeded total synthesis, indicating that cycling between acetylcholine and its precursors may occur. phospholine 132-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 3955054-1 1986 The kinetics of the irreversible inhibition of acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7) by diisopropyl fluorophosphate and paraoxon have been studied by the approach of following the substrate reaction continuously in the presence of both the substrate and the inhibitor based on kinetic equations previously derived (Tsou, C.-L. (1965) Acta Biochim. Isoflurophate 115-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 3955054-1 1986 The kinetics of the irreversible inhibition of acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7) by diisopropyl fluorophosphate and paraoxon have been studied by the approach of following the substrate reaction continuously in the presence of both the substrate and the inhibitor based on kinetic equations previously derived (Tsou, C.-L. (1965) Acta Biochim. Paraoxon 147-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 2947781-0 1986 Effect of DMSO and a freezing-thawing process on the "ecto-ATPase" and AChE activities of human platelets. Dimethyl Sulfoxide 10-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 2947781-2 1986 Following treatment of fresh platelets with DMSO (5-20%) quantitative differences of AChE and "ecto-ATPase" activities were seen. Dimethyl Sulfoxide 44-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 2947781-3 1986 After cryopreservation of platelets in 5% DMSO the enzymatic activities of AChE and Mg2+-ATPase were no different from those obtained for fresh platelets. Dimethyl Sulfoxide 42-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 3721921-1 1986 The "direct coloring" thiocholine method of Karnovsky and Roots (1964) for the demonstration of acetylcholinesterase (AChE) activity was modified and adapted to the technique of semipermeable membranes. Thiocholine 22-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 3721921-1 1986 The "direct coloring" thiocholine method of Karnovsky and Roots (1964) for the demonstration of acetylcholinesterase (AChE) activity was modified and adapted to the technique of semipermeable membranes. Thiocholine 22-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 3721921-5 1986 The medium supplemented with buffer (instead of agar) can be used for the demonstration of AChE activity in cryostat sections adherent to slides and is also very suitable for the detection of multiple forms of AChE in polyacrylamide or agarose gels. polyacrylamide 218-232 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-214 2937928-1 1986 We have previously communicated that heparan sulfate and heparin released 16S acetylcholinesterase (AChE) from cholinergic synapses. Heparitin Sulfate 37-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 2937928-1 1986 We have previously communicated that heparan sulfate and heparin released 16S acetylcholinesterase (AChE) from cholinergic synapses. Heparin 57-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 2937928-2 1986 These experiments suggest that heparan-like molecules are involved in the anchorage of AChE to the neuromuscular junction. heparan 31-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 2937928-3 1986 In order to prove the in vivo interaction between the 16S AChE and heparan sulfate residues, the binding of exogenously added 16S enzyme to intact cells rich in cell-surface heparan sulfate proteoglycans was examined; 16S AChE form was shown to bind to intact endothelial cells in a specific, time-dependent, saturable fashion. Sulfur 54-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 2937928-5 1986 Fifty percent of the binding of the 16S AChE was blocked by heparan sulfate, heparin, or previous treatment of the cell with heparitinase. Heparitin Sulfate 60-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 2937928-5 1986 Fifty percent of the binding of the 16S AChE was blocked by heparan sulfate, heparin, or previous treatment of the cell with heparitinase. Heparin 77-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 3755763-5 1986 However, a consensus organophosphate-binding hexapeptide sequence Phe-Gly-Glu-Ser-Ala-Gly was found both in "true" acetylcholinesterase from the electric organ of Torpedo [McPhee-Quigley et al: J Biol Chem 260:12185-12189, 1985] and in "pseudocholinesterase" (butyrylcholinesterase) from human serum [Lockridge: "Cholinesterases--Fundamental and Applied Aspects." Organophosphates 21-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 3963769-1 1986 Acetylcholinesterase (AChE), the enzyme that degrades acetylcholine, is a heterogeneous enzyme that can be separated into multiple molecular forms. Acetylcholine 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 3963769-1 1986 Acetylcholinesterase (AChE), the enzyme that degrades acetylcholine, is a heterogeneous enzyme that can be separated into multiple molecular forms. Acetylcholine 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 3963769-3 1986 The distribution of AChE molecular forms was defined by sucrose density gradients of 11 anatomical regions of postmortem brains from 10 patients with dementia of the Alzheimer type (DAT) and 14 nondemented controls of similar ages. Sucrose 56-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 3468911-2 1986 When the maximal effects of these solvents were tested at +37 degrees C, they diminished the AchE activity: benzene 75%, xylene 65%, styrene 80%, trichloroethylene 55%, tetrachloroethylene 60%, 1,1,1-trichloroethane 25%, and 1,1,2,2-tetrachloroethane 75%. Benzene 108-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 3468911-2 1986 When the maximal effects of these solvents were tested at +37 degrees C, they diminished the AchE activity: benzene 75%, xylene 65%, styrene 80%, trichloroethylene 55%, tetrachloroethylene 60%, 1,1,1-trichloroethane 25%, and 1,1,2,2-tetrachloroethane 75%. Xylenes 121-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 3468911-2 1986 When the maximal effects of these solvents were tested at +37 degrees C, they diminished the AchE activity: benzene 75%, xylene 65%, styrene 80%, trichloroethylene 55%, tetrachloroethylene 60%, 1,1,1-trichloroethane 25%, and 1,1,2,2-tetrachloroethane 75%. Styrene 133-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 3468911-2 1986 When the maximal effects of these solvents were tested at +37 degrees C, they diminished the AchE activity: benzene 75%, xylene 65%, styrene 80%, trichloroethylene 55%, tetrachloroethylene 60%, 1,1,1-trichloroethane 25%, and 1,1,2,2-tetrachloroethane 75%. Trichloroethylene 146-163 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 3468911-2 1986 When the maximal effects of these solvents were tested at +37 degrees C, they diminished the AchE activity: benzene 75%, xylene 65%, styrene 80%, trichloroethylene 55%, tetrachloroethylene 60%, 1,1,1-trichloroethane 25%, and 1,1,2,2-tetrachloroethane 75%. Tetrachloroethylene 169-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 3468911-2 1986 When the maximal effects of these solvents were tested at +37 degrees C, they diminished the AchE activity: benzene 75%, xylene 65%, styrene 80%, trichloroethylene 55%, tetrachloroethylene 60%, 1,1,1-trichloroethane 25%, and 1,1,2,2-tetrachloroethane 75%. 1,1,1-trichloroethane 194-215 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 3468911-2 1986 When the maximal effects of these solvents were tested at +37 degrees C, they diminished the AchE activity: benzene 75%, xylene 65%, styrene 80%, trichloroethylene 55%, tetrachloroethylene 60%, 1,1,1-trichloroethane 25%, and 1,1,2,2-tetrachloroethane 75%. 1,1,2,2-tetrachloroethane 225-250 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 3468911-3 1986 Of the alcohols studied, only ethanol had a slight AchE inhibiting effect at +37 degrees C. The decrease in the incubation temperature increased the AchE inhibiting potency of aromatic hydrocarbons more than that of chlorinated aliphatic hydrocarbons and alcohols. Alcohols 7-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 3468911-3 1986 Of the alcohols studied, only ethanol had a slight AchE inhibiting effect at +37 degrees C. The decrease in the incubation temperature increased the AchE inhibiting potency of aromatic hydrocarbons more than that of chlorinated aliphatic hydrocarbons and alcohols. Ethanol 30-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 3468911-3 1986 Of the alcohols studied, only ethanol had a slight AchE inhibiting effect at +37 degrees C. The decrease in the incubation temperature increased the AchE inhibiting potency of aromatic hydrocarbons more than that of chlorinated aliphatic hydrocarbons and alcohols. Ethanol 30-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 3468911-3 1986 Of the alcohols studied, only ethanol had a slight AchE inhibiting effect at +37 degrees C. The decrease in the incubation temperature increased the AchE inhibiting potency of aromatic hydrocarbons more than that of chlorinated aliphatic hydrocarbons and alcohols. Hydrocarbons, Aromatic 176-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 3468911-3 1986 Of the alcohols studied, only ethanol had a slight AchE inhibiting effect at +37 degrees C. The decrease in the incubation temperature increased the AchE inhibiting potency of aromatic hydrocarbons more than that of chlorinated aliphatic hydrocarbons and alcohols. Hydrocarbons, Aromatic 176-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 3468911-3 1986 Of the alcohols studied, only ethanol had a slight AchE inhibiting effect at +37 degrees C. The decrease in the incubation temperature increased the AchE inhibiting potency of aromatic hydrocarbons more than that of chlorinated aliphatic hydrocarbons and alcohols. Alcohols 255-263 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 3755763-5 1986 However, a consensus organophosphate-binding hexapeptide sequence Phe-Gly-Glu-Ser-Ala-Gly was found both in "true" acetylcholinesterase from the electric organ of Torpedo [McPhee-Quigley et al: J Biol Chem 260:12185-12189, 1985] and in "pseudocholinesterase" (butyrylcholinesterase) from human serum [Lockridge: "Cholinesterases--Fundamental and Applied Aspects." Serine 78-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 3755763-5 1986 However, a consensus organophosphate-binding hexapeptide sequence Phe-Gly-Glu-Ser-Ala-Gly was found both in "true" acetylcholinesterase from the electric organ of Torpedo [McPhee-Quigley et al: J Biol Chem 260:12185-12189, 1985] and in "pseudocholinesterase" (butyrylcholinesterase) from human serum [Lockridge: "Cholinesterases--Fundamental and Applied Aspects." Glycine 70-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 20493110-2 1986 Acetylcholine and choline are first separated by HPLC then react in a mini-column with acetylcholinesterase and choline oxidase immobilized on Sepharose. Acetylcholine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 20493110-2 1986 Acetylcholine and choline are first separated by HPLC then react in a mini-column with acetylcholinesterase and choline oxidase immobilized on Sepharose. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 3484831-7 1986 The relationship between VBR and AChE activity demonstrates an association between two independently determined pre-mortem measures of illness. vbr 25-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 4004881-0 1985 Identification of covalently bound inositol in the hydrophobic membrane-anchoring domain of Torpedo acetylcholinesterase. Inositol 35-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 20493122-4 1986 The AChE activities in NaCl/Triton X-100 extracts from the three groups of patients were all more or less the same, and average levels were similar to those evidenced in controls. Sodium Chloride 23-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 20493122-4 1986 The AChE activities in NaCl/Triton X-100 extracts from the three groups of patients were all more or less the same, and average levels were similar to those evidenced in controls. Octoxynol 28-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 3933520-0 1985 The solubilization of platelet membrane-bound acetylcholinesterase and aryl acylamidase by exogenous or endogenous phosphatidylinositol specific phospholipase C. Phosphatidylinositol specific phospholipase C from Staphylococcus aureus could solubilize acetylcholinesterase up to 55% from sheep platelets in the presence of ethylenediaminetetra acetic acid (EDTA). Phosphatidylinositols 115-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 3933520-0 1985 The solubilization of platelet membrane-bound acetylcholinesterase and aryl acylamidase by exogenous or endogenous phosphatidylinositol specific phospholipase C. Phosphatidylinositol specific phospholipase C from Staphylococcus aureus could solubilize acetylcholinesterase up to 55% from sheep platelets in the presence of ethylenediaminetetra acetic acid (EDTA). Phosphatidylinositols 115-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 252-272 3933520-0 1985 The solubilization of platelet membrane-bound acetylcholinesterase and aryl acylamidase by exogenous or endogenous phosphatidylinositol specific phospholipase C. Phosphatidylinositol specific phospholipase C from Staphylococcus aureus could solubilize acetylcholinesterase up to 55% from sheep platelets in the presence of ethylenediaminetetra acetic acid (EDTA). Phosphatidylinositols 162-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 3933520-0 1985 The solubilization of platelet membrane-bound acetylcholinesterase and aryl acylamidase by exogenous or endogenous phosphatidylinositol specific phospholipase C. Phosphatidylinositol specific phospholipase C from Staphylococcus aureus could solubilize acetylcholinesterase up to 55% from sheep platelets in the presence of ethylenediaminetetra acetic acid (EDTA). Phosphatidylinositols 162-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 252-272 3933520-0 1985 The solubilization of platelet membrane-bound acetylcholinesterase and aryl acylamidase by exogenous or endogenous phosphatidylinositol specific phospholipase C. Phosphatidylinositol specific phospholipase C from Staphylococcus aureus could solubilize acetylcholinesterase up to 55% from sheep platelets in the presence of ethylenediaminetetra acetic acid (EDTA). Edetic Acid 323-355 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 3933520-0 1985 The solubilization of platelet membrane-bound acetylcholinesterase and aryl acylamidase by exogenous or endogenous phosphatidylinositol specific phospholipase C. Phosphatidylinositol specific phospholipase C from Staphylococcus aureus could solubilize acetylcholinesterase up to 55% from sheep platelets in the presence of ethylenediaminetetra acetic acid (EDTA). Edetic Acid 357-361 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 3933520-3 1985 It is suggested that phosphatidylinositol specific phospholipase C will be a useful tool in the solubilization of acetylcholinesterase from mammalian sources and its purification free of detergents. Phosphatidylinositols 21-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 3835042-0 1985 Inhibition of acetylcholinesterase by histamine agonists and antagonists. Histamine 38-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 3835042-19 1985 The clinical implications of acetylcholinesterase inhibition by cimetidine and ranitidine are discussed. Cimetidine 64-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 4045459-0 1985 Solubilization of membrane-bound acetylcholinesterase by a phosphatidylinositol-specific phospholipase C. Phosphatidylinositol-specific phospholipase C (PIPLC) quantitatively solubilizes acetylcholinesterase (AChE) from purified synaptic plasma membranes and intact synaptosomes of Torpedo ocellata electric organ. Phosphatidylinositols 59-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-213 4045459-0 1985 Solubilization of membrane-bound acetylcholinesterase by a phosphatidylinositol-specific phospholipase C. Phosphatidylinositol-specific phospholipase C (PIPLC) quantitatively solubilizes acetylcholinesterase (AChE) from purified synaptic plasma membranes and intact synaptosomes of Torpedo ocellata electric organ. Phosphatidylinositols 106-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-213 4045465-4 1985 The activity was decreased by hemicholinium-3, an inhibitor of choline uptake and slightly activated by neostigmine, an acetylcholinesterase inhibitor. Hemicholinium 3 30-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 4045465-4 1985 The activity was decreased by hemicholinium-3, an inhibitor of choline uptake and slightly activated by neostigmine, an acetylcholinesterase inhibitor. Neostigmine 104-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 4045469-2 1985 The method is based on a separation of choline and acetylcholine by cation exchange HPLC followed by passage of the effluent through a postcolumn reactor containing a mixture of acetylcholinesterase and choline oxidase; the latter enzyme converts choline to betaine and hydrogen peroxide, the former enzyme hydrolyzes acetylcholine to acetate and choline. Betaine 258-265 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-198 4045469-2 1985 The method is based on a separation of choline and acetylcholine by cation exchange HPLC followed by passage of the effluent through a postcolumn reactor containing a mixture of acetylcholinesterase and choline oxidase; the latter enzyme converts choline to betaine and hydrogen peroxide, the former enzyme hydrolyzes acetylcholine to acetate and choline. Hydrogen Peroxide 270-287 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-198 4045469-2 1985 The method is based on a separation of choline and acetylcholine by cation exchange HPLC followed by passage of the effluent through a postcolumn reactor containing a mixture of acetylcholinesterase and choline oxidase; the latter enzyme converts choline to betaine and hydrogen peroxide, the former enzyme hydrolyzes acetylcholine to acetate and choline. Acetates 335-342 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-198 4038330-0 1985 Inhibition of acetylcholinesterase by neurotoxic aminonitriles. aminonitriles 49-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 4064078-0 1985 Interaction of heparin with multimolecular aggregates of acetylcholinesterase. Heparin 15-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 4064078-1 1985 It has been reported previously that heparin, a sulfated glycosaminoglycan, releases the asymmetric 16 S form of acetylcholinesterase (AChE) from cholinergic synapses. Heparin 37-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-133 4064078-1 1985 It has been reported previously that heparin, a sulfated glycosaminoglycan, releases the asymmetric 16 S form of acetylcholinesterase (AChE) from cholinergic synapses. Heparin 37-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 4064078-2 1985 Here it is shown that heparin releases the synaptic AChE not as individual 16 S species but as multimolecular aggregates (30 S) of such molecules. Heparin 22-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 4064078-3 1985 Heparin is able to convert low-ionic strength AChE aggregates into a heparin type of AChE aggregates. Heparin 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 4064078-3 1985 Heparin is able to convert low-ionic strength AChE aggregates into a heparin type of AChE aggregates. Heparin 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 4064078-4 1985 Our results suggest that the AChE aggregates detached by heparin are likely to be the physiologically important state of aggregation of the 16 S AChE form in the synaptic basal lamina. Heparin 57-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 4064078-4 1985 Our results suggest that the AChE aggregates detached by heparin are likely to be the physiologically important state of aggregation of the 16 S AChE form in the synaptic basal lamina. Heparin 57-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 3903413-2 1985 Acetylcholine and choline were first separated using reverse-phase chromatography; acetylcholine was then hydrolyzed post-column to choline by acetylcholinesterase. Acetylcholine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 3903413-2 1985 Acetylcholine and choline were first separated using reverse-phase chromatography; acetylcholine was then hydrolyzed post-column to choline by acetylcholinesterase. Acetylcholine 83-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 4094677-6 1985 In connection with the aforementioned, we were interested in studying the activity of acetylcholinesterase (AChE) and monoamine oxidase (MAO), which participate in the metabolism of acetylcholine and catecholamines, respectively, in the process of a change in the food-motivated behavior of animals in the micro- and ultrastructures of certain hypothalamic nuclei and the cerebral cortex. Acetylcholine 86-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 4094677-6 1985 In connection with the aforementioned, we were interested in studying the activity of acetylcholinesterase (AChE) and monoamine oxidase (MAO), which participate in the metabolism of acetylcholine and catecholamines, respectively, in the process of a change in the food-motivated behavior of animals in the micro- and ultrastructures of certain hypothalamic nuclei and the cerebral cortex. Catecholamines 200-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 4094677-6 1985 In connection with the aforementioned, we were interested in studying the activity of acetylcholinesterase (AChE) and monoamine oxidase (MAO), which participate in the metabolism of acetylcholine and catecholamines, respectively, in the process of a change in the food-motivated behavior of animals in the micro- and ultrastructures of certain hypothalamic nuclei and the cerebral cortex. Catecholamines 200-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 4060156-0 1985 Kinetic analysis of inhibition of brain and red blood cell acetylcholinesterase and plasma cholinesterase by acephate or methamidophos. acephate 109-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 4060156-0 1985 Kinetic analysis of inhibition of brain and red blood cell acetylcholinesterase and plasma cholinesterase by acephate or methamidophos. methamidophos 121-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 4060156-1 1985 In this investigation of two insecticides, methamidophos was at least 75 to 100 times more potent an inhibitor of acetylcholinesterase (AChE) and cholinesterase (ChE) than was acephate. methamidophos 43-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 4060156-1 1985 In this investigation of two insecticides, methamidophos was at least 75 to 100 times more potent an inhibitor of acetylcholinesterase (AChE) and cholinesterase (ChE) than was acephate. methamidophos 43-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 4060156-3 1985 The affinity (as measured by Ka values) of acephate was greater than that of methamidophos to both the AChE and the ChE active sites. acephate 43-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 4060156-3 1985 The affinity (as measured by Ka values) of acephate was greater than that of methamidophos to both the AChE and the ChE active sites. methamidophos 77-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 4060156-6 1985 The inhibition potency [as measured by Ki and the concentration required to cause 50% inhibition in AChE or ChE activity (IC50 values)] of methamidophos, but not of acephate, increased by lengthening the enzyme-inhibitor incubation time. methamidophos 139-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 4041620-3 1985 This study presents the ultrastructural localization of AChE activity in human thymus cells, using the indirect thiocholine method. Thiocholine 112-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 4052103-0 1985 Reactivation of ethyl methylphosphonylated eel acetylcholinesterase in vitro by 2PAM, H16, and a series of nonquaternary alpha-ketothiohydroximates. alpha-ketothiohydroximates 121-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 4077467-2 1985 The inhibition of eel acetylcholinesterase by physostigmine at 20 degrees and 25 degrees C have been investigated. Physostigmine 46-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 3912371-0 1985 Isolation of human erythrocyte acetylcholinesterase using phase separation with Triton X-114 and monoclonal immunosorbent chromatography. Nonidet P-40 80-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 3912371-5 1985 This material was used to raise monoclonal anti-AchE antibodies which, when applied to immunosorbent chromatography of washed Triton X-100-lysed erythrocytes in one step, allowed a 246,000-fold purification of AchE with a yield of 88% and a specific activity of 3800 IU/mg. Octoxynol 126-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 4009167-3 1985 Two major forms of acetylcholinesterase activity, sedimenting at 10-11S and 4-5S, respectively, were detected on sucrose gradients and possessed similar catalytic properties, as judged by their individual Km values toward [3H]acetylcholine (ca. Sucrose 113-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 4009167-3 1985 Two major forms of acetylcholinesterase activity, sedimenting at 10-11S and 4-5S, respectively, were detected on sucrose gradients and possessed similar catalytic properties, as judged by their individual Km values toward [3H]acetylcholine (ca. Tritium 223-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 4037298-6 1985 Human erythrocyte acetylcholinesterase contained two N-terminal amino acids with stoichiometries of 0.66 Glu and 0.34 Arg per 70-kDa subunit. Glutamic Acid 105-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 4037298-6 1985 Human erythrocyte acetylcholinesterase contained two N-terminal amino acids with stoichiometries of 0.66 Glu and 0.34 Arg per 70-kDa subunit. Arginine 118-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 4037298-7 1985 Identification of Glu as the principal N-terminus of acetylcholinesterase was confirmed by Edman sequencing. Glutamic Acid 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 4005268-3 1985 As the 5.6 S acetylcholinesterase forms larger oligomers in the absence of detergent, the CD spectrum was measured both with and without detergent. Cadmium 90-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-33 4005268-5 1985 Binding of edrophonium to the active site of 11 S acetylcholinesterase increases alpha-helix, while binding of propidium to the peripheral site increases beta-sheet. Edrophonium 11-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 4005268-6 1985 The beta-sheet content is slightly higher for 5.6 S than 11 S acetylcholinesterase in water. Water 86-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 4004881-1 1985 The hydrophobic, membrane-bound form of Torpedo acetylcholinesterase is specifically solubilized by a phosphatidylinositol-specific phospholipase C, suggesting that acetylcholinesterase is bound to the membrane via a direct and specific interaction with phosphatidylinositol (Futerman et al., Biochem. Phosphatidylinositols 102-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 4004881-1 1985 The hydrophobic, membrane-bound form of Torpedo acetylcholinesterase is specifically solubilized by a phosphatidylinositol-specific phospholipase C, suggesting that acetylcholinesterase is bound to the membrane via a direct and specific interaction with phosphatidylinositol (Futerman et al., Biochem. Phosphatidylinositols 102-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-185 4004881-1 1985 The hydrophobic, membrane-bound form of Torpedo acetylcholinesterase is specifically solubilized by a phosphatidylinositol-specific phospholipase C, suggesting that acetylcholinesterase is bound to the membrane via a direct and specific interaction with phosphatidylinositol (Futerman et al., Biochem. Phosphatidylinositols 254-274 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 4004881-1 1985 The hydrophobic, membrane-bound form of Torpedo acetylcholinesterase is specifically solubilized by a phosphatidylinositol-specific phospholipase C, suggesting that acetylcholinesterase is bound to the membrane via a direct and specific interaction with phosphatidylinositol (Futerman et al., Biochem. Phosphatidylinositols 254-274 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-185 4004881-4 1985 Here we demonstrate the presence of covalently bound inositol in the membrane-anchoring domain of purified Torpedo acetylcholinesterase. Inositol 53-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 4004881-6 1985 The results presented strongly support our suggestion that phosphatidylinositol is indeed involved in anchoring acetylcholinesterase to the plasma membrane. Phosphatidylinositols 59-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 3982230-1 1985 This report documents studies on the spontaneous reactivation of human erythrocyte acetylcholinesterase and human serum butyrylcholinesterase following inhibition by organophosphinate esters. organophosphinate esters 166-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 3982230-4 1985 Using the same criteria, the most active compound in the human erythrocyte acetylcholinesterase studies was 4-nitrophenyl methyl(phenyl)phosphinate (74.2% recovery). O-4-(nitrophenyl)methylphenyl phosphinate 108-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 3986218-7 1985 The total acetylcholinesterase activity was determined after adding Triton X-100 to the assay medium. Octoxynol 68-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-30 3986218-8 1985 When adrenal medullary tissue was homogenized in buffers containing echothiopate, an inhibitor of acetylcholinesterase, only 15-20% of enzyme activity was inhibited, excluding the possibility that main granule acetylcholinesterase could be due to contamination by plasma membrane fragments, endoplasmic reticulum and Golgi membranes. echothiopate 68-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-118 3980478-5 1985 The purified acetylcholinesterase was stable at 4 degrees C for at least 8 weeks but was labile to freezing; however, in 50% glycerol the enzyme was stable at -20 degrees C for at least 12 weeks. Glycerol 125-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-33 3980478-6 1985 FBS acetylcholinesterase exhibited typical substrate inhibition, had a Km of 120 microM, and a turnover number of 5300 s-1 with the substrate acetylthiocholine. Acetylthiocholine 142-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 3980478-7 1985 The enzyme was highly sensitive to the specific acetylcholinesterase inhibitor 1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one. 1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one 79-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 3980478-8 1985 FBS acetylcholinesterase was characterized as a G4 form of acetylcholinesterase and was distinguished from bovine erythrocyte acetylcholinesterase on the basis of lectin gel binding, [3H] Triton X-100 binding, amino acid composition, number of catalytic subunits/molecule, and hydrodynamic properties. Tritium 184-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 3980478-8 1985 FBS acetylcholinesterase was characterized as a G4 form of acetylcholinesterase and was distinguished from bovine erythrocyte acetylcholinesterase on the basis of lectin gel binding, [3H] Triton X-100 binding, amino acid composition, number of catalytic subunits/molecule, and hydrodynamic properties. Octoxynol 188-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 3986560-5 1985 The neurotoxicity is believed to arise from oxidative conversion to DPE-N-oxide, which selectively inhibits AChE. dpe-n-oxide 68-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 3867447-0 1985 [Acetylcholinesterase activity in the mixed saliva of subjects living in areas of differing fluoride content in the drinking water]. Fluorides 92-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 1-21 4023425-6 1985 In addition, the extent of NAD-effect using acetylcholinesterase (AChE) was lesser than that of CEase, therefore, a higher susceptibility of liver microsomal CEase to organophosphorus insecticides may be explained, at least inpart, by NAD-effect. NAD 27-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 4023425-6 1985 In addition, the extent of NAD-effect using acetylcholinesterase (AChE) was lesser than that of CEase, therefore, a higher susceptibility of liver microsomal CEase to organophosphorus insecticides may be explained, at least inpart, by NAD-effect. NAD 27-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 2935999-3 1985 After loading with cholesterol activity of acetylcholinesterase was increased while ATPase and glyceraldehyde-3-phosphate dehydrogenase activities were decreased. Cholesterol 19-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 2582308-1 1985 Acetylcholinesterase occurs in the frog sciatic nerve under five stable molecular forms with distinct sedimentation coefficients in sucrose gradients: 3 globular forms (3.6S, 6S and 10.5S) and two asymmetric ones (14S and 18S). Sucrose 132-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 3972833-1 1985 Kinetic and spectroscopic properties of (7-nitrobenz-2-oxa-1,3-diazole)aminoalkyl methylphosphonofluoridates and their conjugates with acetylcholinesterase molecular forms. (7-nitrobenz-2-oxa-1,3-diazole)aminoalkyl methylphosphonofluoridates 40-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 3972833-6 1985 NBD-aminoethyl methylphosphono-acetylcholinesterase undergoes oxime-induced as well as spontaneous reactivation at rates that are 3.6 and 35 times faster, respectively, than the corresponding rates measured for the NBD-aminopentyl conjugate. Oximes 62-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 3972833-10 1985 Bandwidths of the absorption maxima are substantially broader for the acetylcholinesterase adduct with NBD-aminoethyl methylphosphonofluoridate (3870 cm-1) than for the enzyme adduct with NBD-aminopentyl methylphosphonofluoridate (2870 cm-1). 5-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminoethylmethylphosphonofluoridate 103-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 3972833-10 1985 Bandwidths of the absorption maxima are substantially broader for the acetylcholinesterase adduct with NBD-aminoethyl methylphosphonofluoridate (3870 cm-1) than for the enzyme adduct with NBD-aminopentyl methylphosphonofluoridate (2870 cm-1). (7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminopentylmethylphosphonofluoridate 188-229 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 3972833-11 1985 The CD spectrum of NBD-aminopentyl methylphosphono-acetylcholinesterase shows optical activity coincident with the shape and position of the absorption spectrum. Cadmium 4-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 3972833-12 1985 In contrast, in addition to optically active transitions at the absorption maxima, the CD spectrum of NBD-aminoethyl methylphosphono-acetylcholinesterase shows intense optical activity at 430 nm, a wavelength region coincident with the region of spectral broadening. Cadmium 87-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 3986284-0 1985 Ionic strength dependence of the inhibition of acetylcholinesterase activity by Al3+. ALUMINUM ION 80-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 3986284-1 1985 Inhibition of acetylcholinesterase activity by Al3+ has been examined by initial velocity kinetics and by a first-order kinetic method. ALUMINUM ION 47-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 3867447-0 1985 [Acetylcholinesterase activity in the mixed saliva of subjects living in areas of differing fluoride content in the drinking water]. Water 125-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 1-21 3856864-10 1985 In oocytes, hybrid-selected human brain mRNA induced acetylcholinesterase activity that was completely inhibited by 1,5-bis[4-allyldimethylammonium)phenyl]pentan-3-one dibromide but not by tetraisopropyl pyrophosphamide, a differential response to these inhibitors characteristic of "true" human brain acetylcholinesterase. 1,5-bis[4-allyldimethylammonium)phenyl]pentan-3-one dibromide 116-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 3973587-0 1985 Molecular forms of acetylcholinesterase from human caudate nucleus: comparison of salt-soluble and detergent-soluble tetrameric enzyme species. Salts 82-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 3973587-3 1985 The purified, tetrameric salt-soluble (SS) AChE sedimented at 10.6 S and did not bind detergents. Salts 25-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 3973587-9 1985 Limited digestion of DS-AChE with proteinase K led to isolation of an enzyme that no longer bound detergents and lacked the intersubunit disulfide bridges. Disulfides 137-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 4002829-2 1985 Inhibition of acetylcholinesterase by monoterpene derivatives in vitro]. Monoterpenes 38-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 4002829-3 1985 Monoterpene derivatives with spasmolytic activity inhibited acetylcholinesterase (ACHE, EC 3.1.1.7) in a dose dependent manner in vitro. Monoterpenes 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 4002829-3 1985 Monoterpene derivatives with spasmolytic activity inhibited acetylcholinesterase (ACHE, EC 3.1.1.7) in a dose dependent manner in vitro. Monoterpenes 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 3968080-0 1985 Acetylcholinesterase: inhibition by tetranitromethane and arsenite. Tetranitromethane 36-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 3968080-0 1985 Acetylcholinesterase: inhibition by tetranitromethane and arsenite. arsenite 58-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 3968080-2 1985 Tetranitromethane inhibits acetylcholinesterase with respect to the hydrolysis of both acetylthiocholine and indophenyl acetate. Tetranitromethane 0-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 3968080-2 1985 Tetranitromethane inhibits acetylcholinesterase with respect to the hydrolysis of both acetylthiocholine and indophenyl acetate. Acetylthiocholine 87-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 3968080-2 1985 Tetranitromethane inhibits acetylcholinesterase with respect to the hydrolysis of both acetylthiocholine and indophenyl acetate. indophenyl acetate 109-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 3856864-10 1985 In oocytes, hybrid-selected human brain mRNA induced acetylcholinesterase activity that was completely inhibited by 1,5-bis[4-allyldimethylammonium)phenyl]pentan-3-one dibromide but not by tetraisopropyl pyrophosphamide, a differential response to these inhibitors characteristic of "true" human brain acetylcholinesterase. pyrophosphamide 204-219 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 2861006-1 1985 In the caudate nucleus of the species tested about 20% of the acetylcholinesterase was salt soluble and sedimented in sucrose density gradient centrifugation as monomeric 5 S and tetrameric 10 S enzyme. Salts 87-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 3917684-6 1985 79, 640-647) has indicated that the asymmetric forms of Electrophorus acetylcholinesterase bind exclusively to sphingomyelin vesicles through interaction with the collagen-like "tail" portion of the enzyme. Sphingomyelins 111-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 3917684-7 1985 We report here that acetylcholinesterase also binds to phosphatidylcholine vesicles containing saturated fatty acyl chains and to egg phosphatidylcholine vesicles containing cholesterol. Phosphatidylcholines 55-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 3917684-7 1985 We report here that acetylcholinesterase also binds to phosphatidylcholine vesicles containing saturated fatty acyl chains and to egg phosphatidylcholine vesicles containing cholesterol. saturated fatty acyl chains 95-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 3917684-7 1985 We report here that acetylcholinesterase also binds to phosphatidylcholine vesicles containing saturated fatty acyl chains and to egg phosphatidylcholine vesicles containing cholesterol. Phosphatidylcholines 134-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 3917684-7 1985 We report here that acetylcholinesterase also binds to phosphatidylcholine vesicles containing saturated fatty acyl chains and to egg phosphatidylcholine vesicles containing cholesterol. Cholesterol 174-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 3917684-10 1985 The presence of chondroitin sulfate or hyaluronic acid slightly increases the binding of native acetylcholinesterase to sphingomyelin vesicles, while the presence of 1 M NaCl, bovine serum albumin, or tissue fractions enriched in basement membrane diminish binding. Chondroitin Sulfates 16-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 3917684-10 1985 The presence of chondroitin sulfate or hyaluronic acid slightly increases the binding of native acetylcholinesterase to sphingomyelin vesicles, while the presence of 1 M NaCl, bovine serum albumin, or tissue fractions enriched in basement membrane diminish binding. Hyaluronic Acid 39-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 2578203-2 1985 It is suggested that a monoclonal-antibody-based immunoassay may displace polyacrylamide gel electrophoretic analysis of AChE as a complementary test to AFP in prenatal diagnosis of neural-tube defects, since it is a quantitative test largely independent of operator skill and experience. polyacrylamide 74-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 4084346-0 1985 Influence of atropine upon ageing and reactivation of soman inhibited acetylcholinesterase from human erythrocytes. Atropine 13-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 2861006-1 1985 In the caudate nucleus of the species tested about 20% of the acetylcholinesterase was salt soluble and sedimented in sucrose density gradient centrifugation as monomeric 5 S and tetrameric 10 S enzyme. Sucrose 118-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 4084346-7 1985 Reactivation of the non aged phosphonyl-AChE by several pyridinium oximes was enhanced by atropine with the ghost-bound enzyme; the reactivation of the phosphonylated solubilized enzyme, however, was not affected by atropine. phosphonyl 29-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 3965707-0 1985 Reactivators of organophosphorus-inhibited acetylcholinesterase. organophosphorus 16-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 4084346-7 1985 Reactivation of the non aged phosphonyl-AChE by several pyridinium oximes was enhanced by atropine with the ghost-bound enzyme; the reactivation of the phosphonylated solubilized enzyme, however, was not affected by atropine. pyridinium oximes 56-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 4084346-7 1985 Reactivation of the non aged phosphonyl-AChE by several pyridinium oximes was enhanced by atropine with the ghost-bound enzyme; the reactivation of the phosphonylated solubilized enzyme, however, was not affected by atropine. Atropine 90-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 3965707-3 1985 4-[(Hydroxyimino)methyl]-3-methylimidazolium iodides were prepared and tested for their reactivating potency on acetylcholinesterase inhibited by tetraethyl pyrophosphate (TEPP). 4-[(hydroxyimino)methyl]-3-methylimidazolium iodides 0-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 3965707-3 1985 4-[(Hydroxyimino)methyl]-3-methylimidazolium iodides were prepared and tested for their reactivating potency on acetylcholinesterase inhibited by tetraethyl pyrophosphate (TEPP). tetraethyl pyrophosphate 146-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 3965707-3 1985 4-[(Hydroxyimino)methyl]-3-methylimidazolium iodides were prepared and tested for their reactivating potency on acetylcholinesterase inhibited by tetraethyl pyrophosphate (TEPP). tetraethyl pyrophosphate 172-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 6530433-1 1984 A series of affinity chromatography packings for the purification of serine and sulfhydryl esterases (acetylcholinesterase, alkaline phosphatase, urokinase and papain) have been synthesized using commercially available agarose, glass and acrylate parent matrices. Serine 69-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 3993183-1 1985 Incubation of synaptosomal plasma membranes (SPM) with liposomes of phosphatidylserine (PS), phosphatidylinositol (PIN) or phosphatidylglycerol (PGL), led to an increase of acetylcholinesterase (AchE) activity at concentrations of 0.1-1 mumol phospholipids per mg SPM protein. Phosphatidylglycerols 123-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-193 3993183-1 1985 Incubation of synaptosomal plasma membranes (SPM) with liposomes of phosphatidylserine (PS), phosphatidylinositol (PIN) or phosphatidylglycerol (PGL), led to an increase of acetylcholinesterase (AchE) activity at concentrations of 0.1-1 mumol phospholipids per mg SPM protein. Phosphatidylglycerols 123-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 3993183-3 1985 To explain the enzyme stimulation by the acidic phospholipids, AchE was solubilized with the detergent Lubrol-PX and showed no change in the enzyme activity at any PS, PIN or PGL concentration used, indicating that these compounds do not act on the protein molecule directly. Phospholipids 48-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 3993183-3 1985 To explain the enzyme stimulation by the acidic phospholipids, AchE was solubilized with the detergent Lubrol-PX and showed no change in the enzyme activity at any PS, PIN or PGL concentration used, indicating that these compounds do not act on the protein molecule directly. Polidocanol 103-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 3993183-4 1985 Arrhenius plots of AchE activities in untreated SPM (control), exhibited a break point at 23 degrees C, which was decreased to 16-17 degrees C in PS-treated SPM. Phosphatidylserines 146-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 6509071-0 1984 Silicon compounds as substrates and inhibitors of acetylcholinesterase. Silicon 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 6509071-1 1984 Several trimethylsilyl derivatives were found to be ligands of acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7): trimethylsilylethyl acetate (III) and trimethylsilylmethyl acetate (V) are substrates of the enzyme, whereas trimethylsilylethanol (VIII) is a competitive inhibitor. Trimethylsilyl radical 8-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 6509071-1 1984 Several trimethylsilyl derivatives were found to be ligands of acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7): trimethylsilylethyl acetate (III) and trimethylsilylmethyl acetate (V) are substrates of the enzyme, whereas trimethylsilylethanol (VIII) is a competitive inhibitor. trimethylsilylethyl acetate 129-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 3977858-6 1985 The acetylcholinesterase activity is measured by monitoring the increase in light emission produced by the accumulation of choline or by determining the amount of choline generated after a short interval. Choline 123-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 3977858-11 1985 In addition, it was shown that sodium deoxycholate totally inactivated Torpedo acetylcholinesterase but not the Electrophorus enzyme. Deoxycholic Acid 31-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 3993183-0 1985 Control of the activity of brain synaptosome-associated acetylcholinesterase by acidic phospholipids. Phospholipids 87-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 6509071-1 1984 Several trimethylsilyl derivatives were found to be ligands of acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7): trimethylsilylethyl acetate (III) and trimethylsilylmethyl acetate (V) are substrates of the enzyme, whereas trimethylsilylethanol (VIII) is a competitive inhibitor. Trimethylsilylmethyl acetate 167-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 6509071-1 1984 Several trimethylsilyl derivatives were found to be ligands of acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7): trimethylsilylethyl acetate (III) and trimethylsilylmethyl acetate (V) are substrates of the enzyme, whereas trimethylsilylethanol (VIII) is a competitive inhibitor. 1-trimethylsilylethanol 238-259 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 6509071-2 1984 The silicon compounds have kinetic parameters similar to those of their carbon analogues, except for trimethylsilylmethyl acetate, which is a substrate of acetylcholinesterase, whereas its carbon analogue is not susceptible to enzymic hydrolysis. Silicon 4-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-175 6509071-2 1984 The silicon compounds have kinetic parameters similar to those of their carbon analogues, except for trimethylsilylmethyl acetate, which is a substrate of acetylcholinesterase, whereas its carbon analogue is not susceptible to enzymic hydrolysis. Trimethylsilylmethyl acetate 101-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-175 6530433-1 1984 A series of affinity chromatography packings for the purification of serine and sulfhydryl esterases (acetylcholinesterase, alkaline phosphatase, urokinase and papain) have been synthesized using commercially available agarose, glass and acrylate parent matrices. Sepharose 219-226 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 6502594-2 1984 beta-Substituted ethyl acetates, XCH2CH2OCOCH3, have been prepared, and their hydrolysis by acetylcholinesterase has been studied. beta-substituted ethyl acetates 0-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 6502594-2 1984 beta-Substituted ethyl acetates, XCH2CH2OCOCH3, have been prepared, and their hydrolysis by acetylcholinesterase has been studied. xch2ch2ococh3 33-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 6386496-0 1984 Regulation of acetylcholinesterase activity by retinoic acid in a human neuroblastoma cell line. Tretinoin 47-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 6497906-0 1984 The reactivation by oximes of phosphonylated acetylcholinesterase: the possible erroneous interpretation of reactivating potency. Oximes 20-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 6497906-1 1984 A comparative study of the reactivation by two oximes of acetylcholinesterase inhibited by several organophosphates has been made, with particular reference to the dependence of the degree of reactivation produced by an oxime (reactivating potency) upon the concentration of inhibited enzyme. Oximes 47-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 6497906-1 1984 A comparative study of the reactivation by two oximes of acetylcholinesterase inhibited by several organophosphates has been made, with particular reference to the dependence of the degree of reactivation produced by an oxime (reactivating potency) upon the concentration of inhibited enzyme. Organophosphates 99-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 6497906-1 1984 A comparative study of the reactivation by two oximes of acetylcholinesterase inhibited by several organophosphates has been made, with particular reference to the dependence of the degree of reactivation produced by an oxime (reactivating potency) upon the concentration of inhibited enzyme. Oximes 47-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 6543195-2 1984 Such teratomorphogenic effects on the brain produced by psychosocial and/or nutritional deprivation during brain development could be partly prevented--as well as the teratophysiogenic and teratopsychogenic effects--by simultaneous administration of the acetylcholinesterase inhibitor pyridostigmine. Pyridostigmine Bromide 285-299 acetylcholinesterase (Cartwright blood group) Homo sapiens 254-274 6095662-7 1984 Presently, there are rare reports of gynecomastia, bradycardia, inhibition of acetylcholinesterase, headache, lethargy, diarrhea, and rash in patients receiving ranitidine. Ranitidine 161-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 6386496-1 1984 The ability of retinoic acid (RA) to modulate acetylcholinesterase (AChE) activity in a human neuroblastoma cell line (LN-N-5) was examined. Tretinoin 15-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 6386496-1 1984 The ability of retinoic acid (RA) to modulate acetylcholinesterase (AChE) activity in a human neuroblastoma cell line (LN-N-5) was examined. Tretinoin 15-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 6386496-1 1984 The ability of retinoic acid (RA) to modulate acetylcholinesterase (AChE) activity in a human neuroblastoma cell line (LN-N-5) was examined. Tretinoin 30-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 6386496-1 1984 The ability of retinoic acid (RA) to modulate acetylcholinesterase (AChE) activity in a human neuroblastoma cell line (LN-N-5) was examined. Tretinoin 30-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 6386496-2 1984 The specific activity of AChE was significantly increased 3 days after exposure of LA-N-5 to RA and reached its maximum values after 9 or more days of culturing. la-n-5 83-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 6386496-2 1984 The specific activity of AChE was significantly increased 3 days after exposure of LA-N-5 to RA and reached its maximum values after 9 or more days of culturing. Tretinoin 93-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 6386496-3 1984 Dose-response experiments demonstrated that large increases of AChE occurred at RA concentrations between 10(-7) and 10(-6) M with maximum AChE values detected at 10(-6)-10(-5) M. Increased AChE activity paralleled neurite outgrowth in LA-N-5 cultures. Tretinoin 80-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 6386496-3 1984 Dose-response experiments demonstrated that large increases of AChE occurred at RA concentrations between 10(-7) and 10(-6) M with maximum AChE values detected at 10(-6)-10(-5) M. Increased AChE activity paralleled neurite outgrowth in LA-N-5 cultures. Tretinoin 80-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 6386496-3 1984 Dose-response experiments demonstrated that large increases of AChE occurred at RA concentrations between 10(-7) and 10(-6) M with maximum AChE values detected at 10(-6)-10(-5) M. Increased AChE activity paralleled neurite outgrowth in LA-N-5 cultures. Tretinoin 80-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 6386496-4 1984 These findings demonstrate that RA can regulate specific AChE activity in human neuroblastoma cells in a manner consistent with neuronal maturation. Tretinoin 32-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 6492073-5 1984 With imidazolium compound in excess over inhibited enzyme, the kinetics of reactivation are well behaved for EPMP-inhibited AChE and depend on the nature of the alkyl ether group R. For GD-inhibited AChE, maximal reactivation was used to compare compounds because rapid phosphonyl enzyme dealkylation and enzyme reinhibition complicate interpretation of kinetic constants. imidazolium 5-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 6492073-5 1984 With imidazolium compound in excess over inhibited enzyme, the kinetics of reactivation are well behaved for EPMP-inhibited AChE and depend on the nature of the alkyl ether group R. For GD-inhibited AChE, maximal reactivation was used to compare compounds because rapid phosphonyl enzyme dealkylation and enzyme reinhibition complicate interpretation of kinetic constants. imidazolium 5-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-203 6497653-13 1984 The 2-hydroxyimino derivatives protect human erythrocyte AChE and purified bovine erythrocyte AChE from inhibition by soman. 2-hydroxyimino 4-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 6492073-5 1984 With imidazolium compound in excess over inhibited enzyme, the kinetics of reactivation are well behaved for EPMP-inhibited AChE and depend on the nature of the alkyl ether group R. For GD-inhibited AChE, maximal reactivation was used to compare compounds because rapid phosphonyl enzyme dealkylation and enzyme reinhibition complicate interpretation of kinetic constants. Ethyl 4-nitrophenyl methylphosphonate 109-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 6492073-5 1984 With imidazolium compound in excess over inhibited enzyme, the kinetics of reactivation are well behaved for EPMP-inhibited AChE and depend on the nature of the alkyl ether group R. For GD-inhibited AChE, maximal reactivation was used to compare compounds because rapid phosphonyl enzyme dealkylation and enzyme reinhibition complicate interpretation of kinetic constants. Ethyl 4-nitrophenyl methylphosphonate 109-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-203 6492073-5 1984 With imidazolium compound in excess over inhibited enzyme, the kinetics of reactivation are well behaved for EPMP-inhibited AChE and depend on the nature of the alkyl ether group R. For GD-inhibited AChE, maximal reactivation was used to compare compounds because rapid phosphonyl enzyme dealkylation and enzyme reinhibition complicate interpretation of kinetic constants. alkyl ether 161-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 6492073-5 1984 With imidazolium compound in excess over inhibited enzyme, the kinetics of reactivation are well behaved for EPMP-inhibited AChE and depend on the nature of the alkyl ether group R. For GD-inhibited AChE, maximal reactivation was used to compare compounds because rapid phosphonyl enzyme dealkylation and enzyme reinhibition complicate interpretation of kinetic constants. alkyl ether 161-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-203 6492073-5 1984 With imidazolium compound in excess over inhibited enzyme, the kinetics of reactivation are well behaved for EPMP-inhibited AChE and depend on the nature of the alkyl ether group R. For GD-inhibited AChE, maximal reactivation was used to compare compounds because rapid phosphonyl enzyme dealkylation and enzyme reinhibition complicate interpretation of kinetic constants. Gadolinium 186-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 6492073-5 1984 With imidazolium compound in excess over inhibited enzyme, the kinetics of reactivation are well behaved for EPMP-inhibited AChE and depend on the nature of the alkyl ether group R. For GD-inhibited AChE, maximal reactivation was used to compare compounds because rapid phosphonyl enzyme dealkylation and enzyme reinhibition complicate interpretation of kinetic constants. Gadolinium 186-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-203 6514105-4 1984 Combined with thioflavin-T staining to visualize amyloid, this histochemical technique showed that some of these AChE-containing fibers were present in proximity to deposits of amyloid. thioflavin T 14-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 6497653-12 1984 dm-3 oximes the percent of reactivation was: 0-17% for paraoxon-inhibited AChE, 9-49% for sarin-inhibited AChE, 16-65% for VX-inhibited AChE, 0-8% for tabun-inhibited AChE, and 0-4% for soman-inhibited AChE. dm-3 oximes 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 6497653-12 1984 dm-3 oximes the percent of reactivation was: 0-17% for paraoxon-inhibited AChE, 9-49% for sarin-inhibited AChE, 16-65% for VX-inhibited AChE, 0-8% for tabun-inhibited AChE, and 0-4% for soman-inhibited AChE. dm-3 oximes 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 6497653-12 1984 dm-3 oximes the percent of reactivation was: 0-17% for paraoxon-inhibited AChE, 9-49% for sarin-inhibited AChE, 16-65% for VX-inhibited AChE, 0-8% for tabun-inhibited AChE, and 0-4% for soman-inhibited AChE. dm-3 oximes 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 6497653-12 1984 dm-3 oximes the percent of reactivation was: 0-17% for paraoxon-inhibited AChE, 9-49% for sarin-inhibited AChE, 16-65% for VX-inhibited AChE, 0-8% for tabun-inhibited AChE, and 0-4% for soman-inhibited AChE. dm-3 oximes 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 6471073-2 1984 Alpha-heteroaromatic aldoximes and thiohydroximates as reactivators of ethyl methylphosphonyl-acetylcholinesterase in vitro. thiohydroximates 35-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 6497653-12 1984 dm-3 oximes the percent of reactivation was: 0-17% for paraoxon-inhibited AChE, 9-49% for sarin-inhibited AChE, 16-65% for VX-inhibited AChE, 0-8% for tabun-inhibited AChE, and 0-4% for soman-inhibited AChE. dm-3 oximes 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 6497653-12 1984 dm-3 oximes the percent of reactivation was: 0-17% for paraoxon-inhibited AChE, 9-49% for sarin-inhibited AChE, 16-65% for VX-inhibited AChE, 0-8% for tabun-inhibited AChE, and 0-4% for soman-inhibited AChE. Paraoxon 55-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 6589044-1 1984 Acetylcholinesterase, an erythroid marker constitutively expressed in K-562 cells, can be further induced by sodium butyrate. Butyric Acid 109-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 6526442-0 1984 Effect of cardiac arrhythmias & antiarrhythmic drugs on myocardial acetylcholinesterase in the cat. Adenosine Monophosphate 31-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 6493583-4 1984 These results support the hypothesis that extracellular 16S AChE at mammalian skeletal muscle motor endplates is primarily derived from complete, previously assembled 16S molecules originating in myofibers. Sulfur 56-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 6209698-3 1984 Qualitative analysis of AChE by polyacrylamide gel (PAG) electrophoresis in the same series of 541 fluids correctly identified 251 of the 255 pregnancies with open neural tube defect and 29 of the 31 pregnancies with false positive amAFP results. polyacrylamide 32-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 6209698-3 1984 Qualitative analysis of AChE by polyacrylamide gel (PAG) electrophoresis in the same series of 541 fluids correctly identified 251 of the 255 pregnancies with open neural tube defect and 29 of the 31 pregnancies with false positive amAFP results. polyacrylamide gels 52-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 6493583-4 1984 These results support the hypothesis that extracellular 16S AChE at mammalian skeletal muscle motor endplates is primarily derived from complete, previously assembled 16S molecules originating in myofibers. Sulfur 167-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 6466662-1 1984 Human erythrocyte membrane-bound acetylcholinesterase was converted to a monomeric species by treatment of ghosts with 2-mercaptoethanol and iodoacetic acid. Mercaptoethanol 119-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 6478213-3 1984 This facilitation was similar to that previously observed in the same receptor type when acetylcholinesterase (AChE) was inhibited by various organophosphate or carbamate acetylcholinesterase inhibitors (AChEIs)3. Organophosphates 142-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 6471073-5 1984 Eight of the twelve compounds significantly reactivate ethyl methylphosphonyl-AChE, but inherent reactivities are moderate to low: the most potent nonquaternary reactivator, 3-phenyl-5-[(hydroxyimino)methyl]-1,2,4-oxadiazole, is 17 times less reactive than the well-known reactivator 2-[(hydroxyimino)methyl]-1-methylpyridinium iodide (2-PAM). ethyl methylphosphonyl 55-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 6471073-5 1984 Eight of the twelve compounds significantly reactivate ethyl methylphosphonyl-AChE, but inherent reactivities are moderate to low: the most potent nonquaternary reactivator, 3-phenyl-5-[(hydroxyimino)methyl]-1,2,4-oxadiazole, is 17 times less reactive than the well-known reactivator 2-[(hydroxyimino)methyl]-1-methylpyridinium iodide (2-PAM). 3-phenyl-5-[(hydroxyimino)methyl]-1,2,4-oxadiazole 174-224 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 6471073-6 1984 One of the nonquaternary compounds, 3-phenyl-1,2,4-oxadiazole-5-thiohydroximic acid 2-(diethylamino)ethyl S-ester, is a powerful reversible inhibitor of AChE (I50 = 7.5 microM). 3-phenyl-1,2,4-oxadiazole-5-thiohydroximic acid 2-(diethylamino)ethyl s-ester 36-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 6478213-3 1984 This facilitation was similar to that previously observed in the same receptor type when acetylcholinesterase (AChE) was inhibited by various organophosphate or carbamate acetylcholinesterase inhibitors (AChEIs)3. Organophosphates 142-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 6466662-1 1984 Human erythrocyte membrane-bound acetylcholinesterase was converted to a monomeric species by treatment of ghosts with 2-mercaptoethanol and iodoacetic acid. Iodoacetic Acid 141-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 6478213-5 1984 We propose that on H-type synapses detergents may perturb a hypothetical molecular interaction between AChE and the acetylcholine receptor (AChR) by which AChE modulates the ability of the AChR to be activated by ACh or carbachol. Acetylcholine 103-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 6478213-5 1984 We propose that on H-type synapses detergents may perturb a hypothetical molecular interaction between AChE and the acetylcholine receptor (AChR) by which AChE modulates the ability of the AChR to be activated by ACh or carbachol. Carbachol 220-229 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 6466662-3 1984 Monomeric and dimeric acetylcholinesterase showed full enzymatic activity in presence of Triton X-100 whereas in the absence of detergent, activity was decreased to approx. Octoxynol 89-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 6478213-5 1984 We propose that on H-type synapses detergents may perturb a hypothetical molecular interaction between AChE and the acetylcholine receptor (AChR) by which AChE modulates the ability of the AChR to be activated by ACh or carbachol. Carbachol 220-229 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 6329222-3 1984 In order to identify the mechanism of these apparently cholinomimetic actions, the effects of ranitidine on AChE and BuChE were studied. Ranitidine 94-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 6501251-0 1984 Acetylcholinesterase release from mammalian erythrocytes by phosphatidylinositol-specific phospholipase C of Bacillus thuringiensis and characterization of the released enzyme. Phosphatidylinositols 60-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 6501251-1 1984 The mode of acetylcholinesterase release from mammalian erythrocyte membranes by the action of phosphatidylinositol(PI)-specific phospholipase C of Bacillus thuringiensis was studied. Phosphatidylinositols 95-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 6501251-6 1984 The properties of these acetylcholinesterase preparations obtained by the action of PI-specific phospholipase C and/or Triton X-100 were studied in detail. Octoxynol 119-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 6472626-7 1984 A rise in acetylcholinesterase concentration was obtained upon stimulation of the central ends of the sciatic nerves; this was inhibited by atropine but not by N-methylatropine, indicating that the rise was due to increased nervous activity and not to the circulatory effects of the stimulation, since the changes in blood pressure caused by the stimulation remained the same after atropine administration. Atropine 140-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-30 6472626-8 1984 Amphetamine or leptazol raised the levels of acetylcholinesterase but it was not possible to determine whether this was due only to increased central nervous activity, since there was invariably leakage through the blood-brain barrier which by itself would be sufficient to produce the effect. Amphetamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 6472626-8 1984 Amphetamine or leptazol raised the levels of acetylcholinesterase but it was not possible to determine whether this was due only to increased central nervous activity, since there was invariably leakage through the blood-brain barrier which by itself would be sufficient to produce the effect. Pentylenetetrazole 15-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 6726232-4 1984 1- Methylheptyl -gamma- bromoacetoacetate formed a complex with acetylcholinesterase or butyrylcholinesterase without hydrolysis of its own molecule. 2-octyl-gamma-bromoacetoacetate 0-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 6371009-2 1984 Papain and Pronase cleaved these domains with greatest efficiency, as measured by the disaggregation of purified acetylcholinesterase to disulfide-linked dimers (G2) on sucrose density gradients in the absence of detergent. Sucrose 169-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-133 18553477-2 1984 It is based on our finding that electriceel acetylcholinesterase hydrolyzes the D- but not the L-isomer of acetylcarnitine. Acetylcarnitine 107-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 18553477-4 1984 Acetylcholinesterase, covalently attached to alumina, was employed for the resolution of D,L-carnitine; the latter was first chemically acetylated, then stereoselectively hydrolyzed with the immobilized enzyme, and finally the acetyl-L-carnitine and D-carnitine produced were separated by ion-exchange chromatography. Aluminum Oxide 45-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 18553477-4 1984 Acetylcholinesterase, covalently attached to alumina, was employed for the resolution of D,L-carnitine; the latter was first chemically acetylated, then stereoselectively hydrolyzed with the immobilized enzyme, and finally the acetyl-L-carnitine and D-carnitine produced were separated by ion-exchange chromatography. Carnitine 89-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 18553477-4 1984 Acetylcholinesterase, covalently attached to alumina, was employed for the resolution of D,L-carnitine; the latter was first chemically acetylated, then stereoselectively hydrolyzed with the immobilized enzyme, and finally the acetyl-L-carnitine and D-carnitine produced were separated by ion-exchange chromatography. Acetylcarnitine 227-245 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 18553477-4 1984 Acetylcholinesterase, covalently attached to alumina, was employed for the resolution of D,L-carnitine; the latter was first chemically acetylated, then stereoselectively hydrolyzed with the immobilized enzyme, and finally the acetyl-L-carnitine and D-carnitine produced were separated by ion-exchange chromatography. D-carnitine 250-261 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 6466611-0 1984 Activation of acetylcholinesterase by monovalent (Na+,K+) and divalent (Ca2+,Mg2+) cations. magnesium ion 77-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 6466611-1 1984 The activation of acetylcholinesterase [EC 3.1.1.7 (AChE)] by monovalent and divalent metal ions has been investigated by kinetic experiments under steady-state conditions (pH-stat method). Metals 86-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 6329222-6 1984 It appears that ranitidine exerts an inhibition of the "mixed" type on both AChE and BuChE, but the dissociation constants for BuChE were markedly higher than those for AChE. Ranitidine 16-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 6329222-6 1984 It appears that ranitidine exerts an inhibition of the "mixed" type on both AChE and BuChE, but the dissociation constants for BuChE were markedly higher than those for AChE. Ranitidine 16-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 6329222-7 1984 Since AChE inhibition occurs in the same concentration range potentiating the twitch responses on the ileal myenteric preparation, it may explain the cholinomimetic effect of ranitidine. Ranitidine 175-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 6326400-1 1984 An inhibition of acetylcholinesterase activity by ranitidine and cimetidine as described by Hansen and Bertl (Z. Gastroenterol. Ranitidine 50-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 6467040-4 1984 We report a detailed thiocholine protocol and observations on several experimental factors which affect the sensitivity, consistency and the discreteness of localization of AChE in histological material. Thiocholine 21-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-177 6511073-6 1984 In vitro additions of ASA in physiological concentration to the enzyme assay medium inhibited the AChE activity significantly and the inhibition was an un-competitive type. Ascorbic Acid 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 6743696-1 1984 Two soluble forms of AChE from lymphocyte membrane have been obtained, the Triton solubilized Sd form and the high molar salt solubilized Ss form. Salts 121-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 6707734-8 1984 We also examined the effect of increased testosterone in syrinx isolated from neural influences by denervation and found that denervated muscle responded to testosterone with an increase in acetylcholinesterase activity but not with increases in protein content or AChR number. Testosterone 157-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 190-210 6371009-3 1984 Nonspecific proteolytic degradation was reduced both by the inclusion of edrophonium chloride, which protected acetylcholinesterase from inactivation, and by covalent attachment of papain to Sepharose CL-4B. Edrophonium 73-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 6715576-0 1984 Acetylcholinesterase activity in the sexually dimorphic area of the gerbil brain: sex differences and influences of adult gonadal steroids. Steroids 130-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 6715576-6 1984 Optical density readings also indicated that AChE staining is darker in the male SDA. sda 81-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 6326400-1 1984 An inhibition of acetylcholinesterase activity by ranitidine and cimetidine as described by Hansen and Bertl (Z. Gastroenterol. Cimetidine 65-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 6326400-5 1984 In a typical therapeutic situation in 8 patients with ranitidine 150 mg twice daily and cimetidine 400 mg twice daily an inhibiton of the acetylcholinesterase could not be demonstrated. Cimetidine 88-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 6326400-6 1984 The inhibition of the acetylcholinesterase activity by H2-antagonists is of no practical relevance. Hydrogen 55-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 6704184-2 1984 The reaction of acetylcholinesterase (EC 3.1.1.7; human erythrocytes) with phosphostigmine, haloxon and VX was studied, and the effect of three reversible ligands (TMA, edrophonium, coumarin) and of acetylthiocholine upon the time-dependent and time-independent (reversible) inhibition by the organophosphates was evaluated. Parathion 75-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 6704184-2 1984 The reaction of acetylcholinesterase (EC 3.1.1.7; human erythrocytes) with phosphostigmine, haloxon and VX was studied, and the effect of three reversible ligands (TMA, edrophonium, coumarin) and of acetylthiocholine upon the time-dependent and time-independent (reversible) inhibition by the organophosphates was evaluated. haloxon 92-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 6704184-2 1984 The reaction of acetylcholinesterase (EC 3.1.1.7; human erythrocytes) with phosphostigmine, haloxon and VX was studied, and the effect of three reversible ligands (TMA, edrophonium, coumarin) and of acetylthiocholine upon the time-dependent and time-independent (reversible) inhibition by the organophosphates was evaluated. VX 104-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 6704184-2 1984 The reaction of acetylcholinesterase (EC 3.1.1.7; human erythrocytes) with phosphostigmine, haloxon and VX was studied, and the effect of three reversible ligands (TMA, edrophonium, coumarin) and of acetylthiocholine upon the time-dependent and time-independent (reversible) inhibition by the organophosphates was evaluated. coumarin 182-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 6704184-2 1984 The reaction of acetylcholinesterase (EC 3.1.1.7; human erythrocytes) with phosphostigmine, haloxon and VX was studied, and the effect of three reversible ligands (TMA, edrophonium, coumarin) and of acetylthiocholine upon the time-dependent and time-independent (reversible) inhibition by the organophosphates was evaluated. Acetylthiocholine 199-216 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 6704184-2 1984 The reaction of acetylcholinesterase (EC 3.1.1.7; human erythrocytes) with phosphostigmine, haloxon and VX was studied, and the effect of three reversible ligands (TMA, edrophonium, coumarin) and of acetylthiocholine upon the time-dependent and time-independent (reversible) inhibition by the organophosphates was evaluated. Organophosphates 293-309 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 6704184-8 1984 We conclude that phosphostigmine and haloxon bind reversibly to different sites on the enzyme and the experiments agree with a theoretical model that haloxon binds reversibly to a peripheral site on acetylcholinesterase, and phosphostigmine to the catalytic site. Parathion 17-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-219 6704184-8 1984 We conclude that phosphostigmine and haloxon bind reversibly to different sites on the enzyme and the experiments agree with a theoretical model that haloxon binds reversibly to a peripheral site on acetylcholinesterase, and phosphostigmine to the catalytic site. haloxon 37-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-219 6704158-0 1984 Dimethyl sulfoxide: inhibition of acetylcholinesterase in the mammalian heart. Dimethyl Sulfoxide 0-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 6704184-8 1984 We conclude that phosphostigmine and haloxon bind reversibly to different sites on the enzyme and the experiments agree with a theoretical model that haloxon binds reversibly to a peripheral site on acetylcholinesterase, and phosphostigmine to the catalytic site. haloxon 150-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-219 6691983-0 1984 Alkylboronic acids accelerate affinity labelling of acetylcholinesterase with N,N-dimethyl-2-phenylaziridinium ion. alkylboronic acids 0-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 6704158-7 1984 True AChE activity (measured in the presence of a maximally effective concentration of tetraisopropylpyrophosphoramide) had a Vmax of 13.4 +/- 0.17 nmoles X min-1 X mg protein)-1 and an apparent Km value of 1 X 10(-4)M acetylthiocholine. Tetraisopropylpyrophosphamide 87-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 6704158-7 1984 True AChE activity (measured in the presence of a maximally effective concentration of tetraisopropylpyrophosphoramide) had a Vmax of 13.4 +/- 0.17 nmoles X min-1 X mg protein)-1 and an apparent Km value of 1 X 10(-4)M acetylthiocholine. Acetylthiocholine 219-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 6704158-8 1984 At this Km substrate concentration, DMSO inhibited atrial AChE activity (I50 = 9 microliter/ml). Dimethyl Sulfoxide 36-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 6704158-9 1984 At the concentration tested, DMSO inhibited atrial AChE and potentiated ACh effects. Dimethyl Sulfoxide 29-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 6691983-0 1984 Alkylboronic acids accelerate affinity labelling of acetylcholinesterase with N,N-dimethyl-2-phenylaziridinium ion. N,N-dimethyl-2-phenylaziridinium 78-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 6691983-1 1984 The kinetics of acetylcholinesterase alkylation with N,N-dimethyl-2-phenylaziridinium ion, the anionic-site-directed affinity label, has been investigated in the presence of alkylboronic acids, which are known as the esteratic-site-directed reversible inhibitors of the enzyme. N,N-dimethyl-2-phenylaziridinium 53-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 6691983-1 1984 The kinetics of acetylcholinesterase alkylation with N,N-dimethyl-2-phenylaziridinium ion, the anionic-site-directed affinity label, has been investigated in the presence of alkylboronic acids, which are known as the esteratic-site-directed reversible inhibitors of the enzyme. alkylboronic acids 174-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 6698812-0 1984 Ultrastructural localization of acetylcholinesterase activity by means of the electron dense precipitate derived from Koelle"s cuprous thiocholine iodide by treatment with phosphomolybdic acid and osmium tetroxide. koelle"s cuprous thiocholine iodide 118-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 6492134-2 1984 The morphological appearance of phenylisothiocyanate-treated cells was discoid and membrane-bound hydrolases (human acetylcholinesterase, sheep phospholipase A2) were fully active following membrane modification. phenylisothiocyanate 32-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 6441425-3 1984 Sensitive histochemical procedures, with the appropriate controls, suggest a small amount of acetylcholinesterase is associated with chromaffin vesicles. chromaffin 133-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 6146468-0 1984 Ecdysterone induces acetylcholinesterase in mammalian brain. Ecdysterone 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 6698812-0 1984 Ultrastructural localization of acetylcholinesterase activity by means of the electron dense precipitate derived from Koelle"s cuprous thiocholine iodide by treatment with phosphomolybdic acid and osmium tetroxide. phosphomolybdic acid 172-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 6698812-0 1984 Ultrastructural localization of acetylcholinesterase activity by means of the electron dense precipitate derived from Koelle"s cuprous thiocholine iodide by treatment with phosphomolybdic acid and osmium tetroxide. Osmium Tetroxide 197-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 6661467-2 1983 AChE activity was assayed by a radioenzymatic method involving the direct extraction of hydrolyzed 3H-acetate into a toluene-based scintillation fluid followed by liquid scintillation spectrometry. 3h-acetate 99-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 6599819-0 1984 Some possibilities of protection against acetylcholinesterase inhibition by organophosphates in vivo. Organophosphates 76-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 6661467-2 1983 AChE activity was assayed by a radioenzymatic method involving the direct extraction of hydrolyzed 3H-acetate into a toluene-based scintillation fluid followed by liquid scintillation spectrometry. Toluene 117-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 6661467-4 1983 Greater than 90% of AChE activity in CSF could be inhibited by 10(-3) M eserine. Physostigmine 72-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 6139754-3 1983 Short-term culture of F9 line cells with RA and dibutyryl cyclic AMP results in a biochemically demonstrable rise in acetylcholinesterase (AChE) activity. Bucladesine 48-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 6664495-8 1983 The ability of acetylcholinesterase to hydrolyse naturally occurring compounds of different chemical nature, like esters and peptides, may help explain the long-standing puzzle of why the enzyme is more widely distributed than acetylcholine, once thought to be its sole natural substrate. Esters 114-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 6664495-8 1983 The ability of acetylcholinesterase to hydrolyse naturally occurring compounds of different chemical nature, like esters and peptides, may help explain the long-standing puzzle of why the enzyme is more widely distributed than acetylcholine, once thought to be its sole natural substrate. Peptides 125-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 6640351-2 1983 Administration of aromatizable (T and androstenedione) or non-aromatizable (androsterone) androgens to castrates increased total activity of acetylcholinesterase (AChE) in the syrinx. Androstenedione 38-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 6640351-2 1983 Administration of aromatizable (T and androstenedione) or non-aromatizable (androsterone) androgens to castrates increased total activity of acetylcholinesterase (AChE) in the syrinx. Androstenedione 38-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 6640351-2 1983 Administration of aromatizable (T and androstenedione) or non-aromatizable (androsterone) androgens to castrates increased total activity of acetylcholinesterase (AChE) in the syrinx. Androsterone 76-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 6139754-3 1983 Short-term culture of F9 line cells with RA and dibutyryl cyclic AMP results in a biochemically demonstrable rise in acetylcholinesterase (AChE) activity. Bucladesine 48-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 6640351-2 1983 Administration of aromatizable (T and androstenedione) or non-aromatizable (androsterone) androgens to castrates increased total activity of acetylcholinesterase (AChE) in the syrinx. Androsterone 76-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 6662290-5 1983 Because of the rapid and slowly reversible inhibition of acetylcholinesterase by organophosphate insecticides, hemoperfusion alone will not improve the clinical status of organophosphate insecticide poisoned patients. Organophosphates 81-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 6226224-6 1983 Thus, acetylcholinesterase inhibitor therapy in subjects with myasthenia gravis with airflow limitation led to significant increase in airways resistance that could be completely reversed by the inhalation of the muscarinic receptor blocker ipratropium bromide. Ipratropium 241-260 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-26 6362479-6 1983 Electrophoresis on the mixed disulfide-polyacrylamide gel proved to be a rapid and sensitive technique to detect very small amounts of enzyme (approximately 0.02 fmol acetylcholinesterase) and should have wide application for detecting other enzymes that hydrolyze thiol substrates. Disulfides 29-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-187 6362479-6 1983 Electrophoresis on the mixed disulfide-polyacrylamide gel proved to be a rapid and sensitive technique to detect very small amounts of enzyme (approximately 0.02 fmol acetylcholinesterase) and should have wide application for detecting other enzymes that hydrolyze thiol substrates. polyacrylamide 39-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-187 6639987-6 1983 The thiophosphoorganic derivatives containing a beta-alanine residue in the cleaved part are more specific to acetylcholinesterase and carboxylesterase than those containing a valine residue. beta-Alanine 48-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-151 6639987-8 1983 During the interaction of the enanthiomers with the asymmetric phosphorus the stereospecificity of acetylcholinesterase is much higher than that of carboxylesterase. Phosphorus 63-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 6628889-5 1983 The antagonistic efficacy of these antidotes against pinacolyl methylphosphonofluoridate may be attributed to their direct antagonism at nicotinic receptor as well as reactivation of inhibited acetylcholinesterase. Soman 53-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-213 6875557-0 1983 Isolation of the secretory form of soluble acetylcholinesterase by using affinity chromatography on edrophonium-Sepharose. edrophonium-sepharose 100-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 6875557-6 1983 The edrophonium-Sepharose matrix bound only one form of acetylcholinesterase. Sepharose 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 6576258-1 1983 Amniotic fluid acetylcholinesterase (AChe) activity was assayed in second trimester amniotic fluids by inhibition of non-specific cholinesterase using lysivane. profenamine 151-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 6576258-1 1983 Amniotic fluid acetylcholinesterase (AChe) activity was assayed in second trimester amniotic fluids by inhibition of non-specific cholinesterase using lysivane. profenamine 151-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 6639069-0 1983 The inhibition of acetylcholinesterase by arsenite and fluoride. arsenite 42-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 6639069-0 1983 The inhibition of acetylcholinesterase by arsenite and fluoride. Fluorides 55-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 6639069-1 1983 The effect of fluoride on the rate of reaction of acetylcholinesterase with arsenite, on the rate of dissociation of the enzyme-arsenite complex, and on the equilibrium between enzyme and arsenite was studied. arsenite 76-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 6639069-2 1983 Fluoride decreases the rate of the reaction between acetylcholinesterase and arsenite and changes the apparent equilibrium dissociation constant between the enzyme and arsenite, but even at concentrations as high as 0.2 M has no effect on the rate of dissociation of the enzyme-arsenite complex. Fluorides 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 6575918-6 1983 Butyrate greatly increased the activity of acetylcholinesterase, slightly enhanced the production of hemoglobin, but did not modify the expression of glycophorin and spectrin. Butyrates 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 6343747-4 1983 The results are used to discuss an interaction analogous to that of Ach with receptor and another one analogous to that of Ach and AchE. Acetylcholine 68-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 6135150-1 1983 The binding of [3H]quinuclidinyl benzilate ([3H]QNB) to cardiac muscarinic receptors was inhibited not only by classical muscarinic antagonists but also by nicotinic blocking agents and inhibitors of acetylcholinesterase. [3h]quinuclidinyl benzilate 15-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-220 6135150-1 1983 The binding of [3H]quinuclidinyl benzilate ([3H]QNB) to cardiac muscarinic receptors was inhibited not only by classical muscarinic antagonists but also by nicotinic blocking agents and inhibitors of acetylcholinesterase. 3-quinuclidinyl 4-fluoromethylbenzilate 44-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-220 6137769-1 1983 Acetylcholinesterase (AChE) activity was measured in the presence of the specific inhibitor of pseudocholinesterase, iso-OMPA, in plasma from patients with amyotrophic lateral sclerosis (ALS), progressive muscular atrophy (PMA), neuromuscular disease controls, and normal controls. Tetraisopropylpyrophosphamide 117-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 6137769-1 1983 Acetylcholinesterase (AChE) activity was measured in the presence of the specific inhibitor of pseudocholinesterase, iso-OMPA, in plasma from patients with amyotrophic lateral sclerosis (ALS), progressive muscular atrophy (PMA), neuromuscular disease controls, and normal controls. Tetraisopropylpyrophosphamide 117-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 6864218-2 1983 The method is based on the separation of ACh and Ch by reverse-phase HPLC and mixing the effluent as it emerges from the column with acetylcholinesterase and Ch oxidase, which converts endogenous Ch and Ch produced by the hydrolysis of ACh to betaine and hydrogen peroxide. Acetylcholine 41-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 6864218-2 1983 The method is based on the separation of ACh and Ch by reverse-phase HPLC and mixing the effluent as it emerges from the column with acetylcholinesterase and Ch oxidase, which converts endogenous Ch and Ch produced by the hydrolysis of ACh to betaine and hydrogen peroxide. Acetylcholine 236-239 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 6864218-2 1983 The method is based on the separation of ACh and Ch by reverse-phase HPLC and mixing the effluent as it emerges from the column with acetylcholinesterase and Ch oxidase, which converts endogenous Ch and Ch produced by the hydrolysis of ACh to betaine and hydrogen peroxide. Betaine 243-250 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 6864218-2 1983 The method is based on the separation of ACh and Ch by reverse-phase HPLC and mixing the effluent as it emerges from the column with acetylcholinesterase and Ch oxidase, which converts endogenous Ch and Ch produced by the hydrolysis of ACh to betaine and hydrogen peroxide. Hydrogen Peroxide 255-272 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 6840242-2 1983 It is possible to measure AChE activity in human plasma in spite of high butyrylcholinesterase activity if acetyl-beta-methylcholine is used as the substrate and butyrylcholinesterase is inhibited by iso-OMPA. Methacholine Chloride 107-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 6191833-1 1983 The possibility that cholinergic neurons of the basal forebrain project to the spinal cord was investigated utilizing the retrograde transport of bisbenzimide and [3H]choline as well as acetylcholinesterase histochemistry. Choline 21-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-206 6189639-3 1983 We evaluated four direct and indirect procedures for measuring AChE in which thiocholine is generated. Thiocholine 77-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 6189639-8 1983 The rapid AChE assay involving acetyl-beta-methylthiocholine, when applied alongside a rapid alpha-fetoprotein assay, increases the efficiency of screening programs for pregnancies with neural tube defect to 99.4%. acetyl-beta-(methylthio)choline 31-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-14 6136252-0 1983 A potential systematic error in using lysivane as inhibitor in the measurement of amniotic fluid acetylcholinesterase by the Ellman method. profenamine 38-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 6136252-1 1983 The measurement of low levels of cholinesterase or acetylcholinesterase by the Ellman method requires correction for a non-enzymatic increase in absorption at 412 millimicron that is due both to non-enzymatic hydrolysis of the acetylthiocholine substrate and to modification of the colour reagent. Acetylthiocholine 227-244 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 6136252-3 1983 Addition of an acidic solution of lysivane to the assay solution for selective measurement of amniotic fluid acetylcholinesterase gives rise to a shift in pH; the use of methanol is suggested as an easier method of dissolving the inhibitor and does not affect the pH of the assay, obviating any need to redetermine the background absorption. profenamine 34-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-129 6885744-0 1983 Release of vesicles containing acetylcholinesterase from erythrocyte membranes by treatment with dilauroylglycerophosphocholine. dilauroylglycerophosphocholine 97-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 6885744-6 1983 The vesicles showed similar characteristics to those generated by ATP depletion; their diameter is 150-200 nm and they are enriched with acetylcholinesterase activity. Adenosine Triphosphate 66-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 6611748-0 1983 Inhibition of acetylcholinesterase activity by some isoquinoline alkaloids. isoquinoline alkaloids 52-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 6849937-1 1983 Acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7), phosphorylated with dichlorvos, showed relatively more reactivity toward the substrate indophenyl acetate than the enzyme that was carbamylated with carbaryl. indophenyl acetate 153-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 6849937-1 1983 Acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7), phosphorylated with dichlorvos, showed relatively more reactivity toward the substrate indophenyl acetate than the enzyme that was carbamylated with carbaryl. Carbaryl 215-223 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 6849970-2 1983 Two substrates were used to estimate the exposure of acetylcholinesterase active site in the membrane: phenylacetate, a hydrophobic substrate, to determine total enzyme activity, and acetylcholine, an ionic substrate, to measure the externally reactive enzyme. phenylacetic acid 103-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 6849970-7 1983 (c) Hereditary spherocytosis was singly differentiated by an elevated acetylcholinesterase activity with acetylthiocholine and by a vastly diminished sensitivity to stearic acid, while activity with phenylacetate was equal to control. Acetylthiocholine 105-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 6870501-0 1983 Synthesis of some new 2-(phenoxyacetylthio)-3-aryl-6-bromo- or -6,8-dibromoquinazoline-4(3H)-ones as possible AChE inhibitors. 2-(phenoxyacetylthio)-3-aryl-6-bromo- or -6,8-dibromoquinazoline-4(3h)-ones 22-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 6840242-2 1983 It is possible to measure AChE activity in human plasma in spite of high butyrylcholinesterase activity if acetyl-beta-methylcholine is used as the substrate and butyrylcholinesterase is inhibited by iso-OMPA. Tetraisopropylpyrophosphamide 200-208 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 7165123-1 1982 The development of motility in porcine spermatozoa as well as the acetylcholinesterase activity of porcine testicular and epididymal spermatozoa in response to chloroquine stimulation were studied. Chloroquine 160-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 6621492-0 1983 The inhibition of erythrocyte acetylcholinesterase by trimethaphan--a comparison with that of pseudocholinesterase. Trimethaphan 54-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 28305505-2 1983 Highest level of total ganglioside concentration was found in the layers of cortical anlage (cortical plate and "subplate layer") which are concomittantly characterized by highest activity of acetylcholinesterase (AChE) and which are known to be involved in intensive synaptogenesis at this stage of cortical development. Gangliosides 23-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-212 28305505-2 1983 Highest level of total ganglioside concentration was found in the layers of cortical anlage (cortical plate and "subplate layer") which are concomittantly characterized by highest activity of acetylcholinesterase (AChE) and which are known to be involved in intensive synaptogenesis at this stage of cortical development. Gangliosides 23-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-218 6410656-1 1983 A temporal and causal relationship has been established between inhibition of acetylcholinesterase (AChE) by organophosphorous compounds, accumulation of Ca2+, an increase of neutral protease activity and the development of the ultrastructural signs of subacute myopathy. organophosphorous 109-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 6410656-1 1983 A temporal and causal relationship has been established between inhibition of acetylcholinesterase (AChE) by organophosphorous compounds, accumulation of Ca2+, an increase of neutral protease activity and the development of the ultrastructural signs of subacute myopathy. organophosphorous 109-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 6402904-3 1983 At concentrations equivalent to, or significantly lower than, those probably achieved during clinical procedures, metrizamide is both an inhibitor of the enzyme acetylcholinesterase and an antagonist of cholinergic transmission. Metrizamide 114-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-181 6193086-0 1983 A modification of thiocholine-ferricyanide method of Karnovsky and Roots for localization of acetylcholinesterase activity without interference by Koelle"s copper thiocholine iodide precipitate. Thiocholine 18-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 6193086-0 1983 A modification of thiocholine-ferricyanide method of Karnovsky and Roots for localization of acetylcholinesterase activity without interference by Koelle"s copper thiocholine iodide precipitate. hexacyanoferrate III 30-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 6193086-1 1983 In the original Karnovsky and Roots" method for the localization of acetylcholinesterase (AChE), thiocholine reduces the ferricyanide and cupric ions of this medium competitively, giving simultaneously cupric (Koelle"s precipitate) as histochemical products. Thiocholine 97-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 6193086-1 1983 In the original Karnovsky and Roots" method for the localization of acetylcholinesterase (AChE), thiocholine reduces the ferricyanide and cupric ions of this medium competitively, giving simultaneously cupric (Koelle"s precipitate) as histochemical products. Thiocholine 97-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 6193086-1 1983 In the original Karnovsky and Roots" method for the localization of acetylcholinesterase (AChE), thiocholine reduces the ferricyanide and cupric ions of this medium competitively, giving simultaneously cupric (Koelle"s precipitate) as histochemical products. hexacyanoferrate III 121-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 6193086-1 1983 In the original Karnovsky and Roots" method for the localization of acetylcholinesterase (AChE), thiocholine reduces the ferricyanide and cupric ions of this medium competitively, giving simultaneously cupric (Koelle"s precipitate) as histochemical products. hexacyanoferrate III 121-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 6193086-7 1983 In this modified medium, Karnovsky"s cupric ferrocyanide becomes the sole precipitate at the enzymatic site and this provides fine localization of acetylcholinesterase activity. hexacyanoferrate II 44-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 20487982-5 1983 The possibility that the results at low ionic strength can be explained on the basis of procaine binding to the active site of acetylcholinesterase (at low concentrations) and also to a peripheral allosteric site (at higher concentrations) is discussed. Procaine 88-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 6830786-1 1983 Purified detergent solubilized dimeric human erythrocyte acetylcholinesterase (6.3 S form) was converted to a stable monomeric 3.9 S species when treated with 2-mercaptoethanol and iodoacetic acid. Mercaptoethanol 159-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 6830786-1 1983 Purified detergent solubilized dimeric human erythrocyte acetylcholinesterase (6.3 S form) was converted to a stable monomeric 3.9 S species when treated with 2-mercaptoethanol and iodoacetic acid. Iodoacetic Acid 181-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 6834035-3 1983 Following direct application of potassium to one substantia nigra, changes occurred in the local release of total protein and acetylcholinesterase, but not nonspecific cholinesterases; changes also were observed in both caudate nuclei and the contralateral substantia nigra. Potassium 32-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 6834035-4 1983 The local evoked release of acetylcholinesterase and of total protein differed in the extent to which they were calcium-dependent. Calcium 112-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 6298631-1 1983 Most of the effects of acetylcholinesterase (AChE) on synaptic transmission are considered to be related to its acetylcholine (ACh) hydrolysing properties. Acetylcholine 23-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 6298631-1 1983 Most of the effects of acetylcholinesterase (AChE) on synaptic transmission are considered to be related to its acetylcholine (ACh) hydrolysing properties. Acetylcholine 45-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 6298631-3 1983 However, we report here that after inhibiting AChE in a cholinergic synapse in Aplysia, we found an increase not only in postsynaptic responses to presynaptic stimulation and to ionophoretic application of ACh on postsynaptic receptors, but also to ionophoretic application of carbachol. Carbachol 277-286 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 6134540-1 1983 The interaction of three new non-depolarizing neuromuscular blocking agents--atracurium, vecuronium and Duador--on human red cell acetylcholinesterase (AChE; EC 3.1.1.7) and human plasma butyrylcholinesterase (BuChE; EC 3.1.1.8) was investigated. Atracurium 77-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 6313528-0 1983 Inhibition of acetylcholinesterase by diisocyanates and its spontaneous reactivation. 4,4'-diphenylmethane diisocyanate 38-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 6313528-1 1983 The inhibition of human acetylcholinesterase (AchE) by 4,4"-diphenylmethane diisocyanate (MDI) is determined and compared with the previously described inhibition of this enzyme by two other industrially used diisocyanates: toluene diisocyanate (TDI) and hexamethylene diisocyanate (HDI). 4,4'-diphenylmethane diisocyanate 55-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 6313528-1 1983 The inhibition of human acetylcholinesterase (AchE) by 4,4"-diphenylmethane diisocyanate (MDI) is determined and compared with the previously described inhibition of this enzyme by two other industrially used diisocyanates: toluene diisocyanate (TDI) and hexamethylene diisocyanate (HDI). 4,4'-diphenylmethane diisocyanate 55-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 6313528-1 1983 The inhibition of human acetylcholinesterase (AchE) by 4,4"-diphenylmethane diisocyanate (MDI) is determined and compared with the previously described inhibition of this enzyme by two other industrially used diisocyanates: toluene diisocyanate (TDI) and hexamethylene diisocyanate (HDI). 4,4'-diphenylmethane diisocyanate 209-222 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 6313528-1 1983 The inhibition of human acetylcholinesterase (AchE) by 4,4"-diphenylmethane diisocyanate (MDI) is determined and compared with the previously described inhibition of this enzyme by two other industrially used diisocyanates: toluene diisocyanate (TDI) and hexamethylene diisocyanate (HDI). 4,4'-diphenylmethane diisocyanate 209-222 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 6313528-1 1983 The inhibition of human acetylcholinesterase (AchE) by 4,4"-diphenylmethane diisocyanate (MDI) is determined and compared with the previously described inhibition of this enzyme by two other industrially used diisocyanates: toluene diisocyanate (TDI) and hexamethylene diisocyanate (HDI). Toluene 2,4-Diisocyanate 224-244 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 6313528-1 1983 The inhibition of human acetylcholinesterase (AchE) by 4,4"-diphenylmethane diisocyanate (MDI) is determined and compared with the previously described inhibition of this enzyme by two other industrially used diisocyanates: toluene diisocyanate (TDI) and hexamethylene diisocyanate (HDI). Toluene 2,4-Diisocyanate 224-244 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 6313528-1 1983 The inhibition of human acetylcholinesterase (AchE) by 4,4"-diphenylmethane diisocyanate (MDI) is determined and compared with the previously described inhibition of this enzyme by two other industrially used diisocyanates: toluene diisocyanate (TDI) and hexamethylene diisocyanate (HDI). Toluene 2,4-Diisocyanate 246-249 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 6313528-1 1983 The inhibition of human acetylcholinesterase (AchE) by 4,4"-diphenylmethane diisocyanate (MDI) is determined and compared with the previously described inhibition of this enzyme by two other industrially used diisocyanates: toluene diisocyanate (TDI) and hexamethylene diisocyanate (HDI). Toluene 2,4-Diisocyanate 246-249 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 6313528-1 1983 The inhibition of human acetylcholinesterase (AchE) by 4,4"-diphenylmethane diisocyanate (MDI) is determined and compared with the previously described inhibition of this enzyme by two other industrially used diisocyanates: toluene diisocyanate (TDI) and hexamethylene diisocyanate (HDI). 1,6-hexamethylene diisocyanate 255-281 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 6313528-1 1983 The inhibition of human acetylcholinesterase (AchE) by 4,4"-diphenylmethane diisocyanate (MDI) is determined and compared with the previously described inhibition of this enzyme by two other industrially used diisocyanates: toluene diisocyanate (TDI) and hexamethylene diisocyanate (HDI). 1,6-hexamethylene diisocyanate 255-281 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 6313528-1 1983 The inhibition of human acetylcholinesterase (AchE) by 4,4"-diphenylmethane diisocyanate (MDI) is determined and compared with the previously described inhibition of this enzyme by two other industrially used diisocyanates: toluene diisocyanate (TDI) and hexamethylene diisocyanate (HDI). 1,6-hexamethylene diisocyanate 283-286 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 6313528-1 1983 The inhibition of human acetylcholinesterase (AchE) by 4,4"-diphenylmethane diisocyanate (MDI) is determined and compared with the previously described inhibition of this enzyme by two other industrially used diisocyanates: toluene diisocyanate (TDI) and hexamethylene diisocyanate (HDI). 1,6-hexamethylene diisocyanate 283-286 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 6343961-4 1983 Acetylcholinesterase activity is measured in the presence of ChE inhibitor, 14 X 10(-6)M lysivane; our results about the inhibitor concentration confirm the previous studies of Dale (Clin. profenamine 89-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 7165123-4 1982 Chloroquine stimulation of testicular and epididymal spermatozoa remarkably enhanced sperm motility and the rate of loss of acetylcholinesterase activity only in spermatozoa obtained from the caudal portions of the epididymis. Chloroquine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 6959823-0 1982 The interaction of acetylcholinesterase with carbodiimides. Carbodiimides 45-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 6815834-5 1982 The 3-compartment model demonstrates the persistence in the blood of 14C activity which correlated with plasma acetylcholinesterase inhibition. Carbon-14 69-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 7139048-4 1982 When acetylcholine is injected on one side of an artificial proteinic membrane bearing acetylcholinesterase, a potential difference is recorded as a function of time. Acetylcholine 5-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 6287570-6 1982 It is suggested that all previously described neuromuscular responses are compatible with new model: the subsynaptic apparatus produces excess acetylcholinesterase (AChE) which limits the endplate conductance changes produced by normal output of ACh. Acetylcholine 165-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 7108585-2 1982 Intracellular AChE was assayed by pretreating intact ganglia with echothiophate to inhibit selectively extracellular enzyme. Echothiophate 66-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 7108585-6 1982 Sucrose gradient velocity sedimentation of Triton X-100 extracts of leech ganglia revealed a major peak of AChE activity at 6.5 S and a small peak at 4.3 S. The pattern of activity in the gradient was the same when intact ganglia were pretreated with echothiophate, although the total activity was reduced by 98%. Sucrose 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 7108585-6 1982 Sucrose gradient velocity sedimentation of Triton X-100 extracts of leech ganglia revealed a major peak of AChE activity at 6.5 S and a small peak at 4.3 S. The pattern of activity in the gradient was the same when intact ganglia were pretreated with echothiophate, although the total activity was reduced by 98%. Octoxynol 43-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 6289994-3 1982 Exposure to the acetylcholinesterase (AChe) inhibitor physostigmine (1 microM) resulted in a 50% increase in electrically evoked [3H]dopamine release. Physostigmine 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 6289994-3 1982 Exposure to the acetylcholinesterase (AChe) inhibitor physostigmine (1 microM) resulted in a 50% increase in electrically evoked [3H]dopamine release. Physostigmine 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 6289994-3 1982 Exposure to the acetylcholinesterase (AChe) inhibitor physostigmine (1 microM) resulted in a 50% increase in electrically evoked [3H]dopamine release. Tritium 130-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 6289994-3 1982 Exposure to the acetylcholinesterase (AChe) inhibitor physostigmine (1 microM) resulted in a 50% increase in electrically evoked [3H]dopamine release. Tritium 130-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 6289994-3 1982 Exposure to the acetylcholinesterase (AChe) inhibitor physostigmine (1 microM) resulted in a 50% increase in electrically evoked [3H]dopamine release. Dopamine 133-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 6289994-3 1982 Exposure to the acetylcholinesterase (AChe) inhibitor physostigmine (1 microM) resulted in a 50% increase in electrically evoked [3H]dopamine release. Dopamine 133-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 6289994-7 1982 The present results suggest that in the electrically depolarized caudate slice in vitro, released endogenous acetylcholine may interact with muscarinic receptors facilitating depolarization-evoked [3H]dopamine release, if AChE is inhibited. Acetylcholine 109-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 222-226 6289994-7 1982 The present results suggest that in the electrically depolarized caudate slice in vitro, released endogenous acetylcholine may interact with muscarinic receptors facilitating depolarization-evoked [3H]dopamine release, if AChE is inhibited. Tritium 198-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 222-226 7132236-1 1982 There is accumulating evidence that acetylcholinesterase (AChE might be involved in the transport of sodium across biological membranes. Sodium 101-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 7132236-1 1982 There is accumulating evidence that acetylcholinesterase (AChE might be involved in the transport of sodium across biological membranes. Sodium 101-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 7132236-4 1982 In the absence of any effectors, the Michaelis constant of AChE for acetylcholine (Km) was 1.57 . Acetylcholine 68-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 7132236-6 1982 Sodium inhibited AChE at low substrate concentrations, whereas the enzyme was activated by sodium at moderate and high substrate levels. Sodium 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 6182963-4 1982 In the brainstem, EB-labelled neurons staining intensely for AChE were found less frequently, but a few were observed in the nucleus tegmenti pendunculopontis, locus ceruleus, subcerulear region, and reticular formation. Evans Blue 18-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 7108127-0 1982 A pseudo-first-order kinetic approach to measurement of acetylcholine hydrolysis by acetylcholinesterase. Acetylcholine 56-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 7096782-0 1982 [Effect of intraperitoneal physostigmine administration on the multiple forms of acetylcholinesterase in different brain structures]. Physostigmine 27-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 7093383-5 1982 After treatment by N,N-dimethyl-2-phenylaziridinium ions which specifically and irreversibly modify the anionic groups on the active surface of AChE, the stereospecificity of the latter is decreased and is approximated to that of BuChE. N,N-dimethyl-2-phenylaziridinium 19-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 7108127-7 1982 7, 88-95) procedure for acetylthiocholine as substrate, are described as a rapid screening technique for reversible competitive and noncompetitive inhibitors of acetylcholinesterase activity. Acetylthiocholine 24-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-181 7336361-4 1981 Vesicle cholinesterase activity was enriched and had a substrate preference consistent with that of acetylcholinesterase (acetylcholine greater than acetyl-beta-methylcholine greater than butyryl-choline). Methacholine Chloride 149-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 7092918-0 1982 Reversible inhibition of acetylcholinesterase by eseroline, an opioid agonist structurally related to physostigmine (eserine) and morphine. eseroline 49-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 7092918-0 1982 Reversible inhibition of acetylcholinesterase by eseroline, an opioid agonist structurally related to physostigmine (eserine) and morphine. Physostigmine 102-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 6279208-0 1982 [Regulation of acetylcholinesterase level in microsomes of neurons by acetylcholine and cyclic nucleotides]. Nucleotides, Cyclic 88-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 6279208-1 1982 In a cell-free system containing isolated nuclei and microsomal-cytoplasmic brain fraction there takes place a spontaneous puromycin-sensitive increase in acetylcholinesterase (AChE) activity of microsomes. Puromycin 123-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-175 6279208-1 1982 In a cell-free system containing isolated nuclei and microsomal-cytoplasmic brain fraction there takes place a spontaneous puromycin-sensitive increase in acetylcholinesterase (AChE) activity of microsomes. Puromycin 123-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-181 6279208-2 1982 As a result of preincubating the system with acetylcholine (ACh) (10(-6)-10(-3) M), AChE activity of microsomes was found to be increased, reaching the maximal value at an ACh concentration of 10(-5) M (25% during 60 min incubation). Acetylcholine 45-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 6279208-2 1982 As a result of preincubating the system with acetylcholine (ACh) (10(-6)-10(-3) M), AChE activity of microsomes was found to be increased, reaching the maximal value at an ACh concentration of 10(-5) M (25% during 60 min incubation). Acetylcholine 60-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 6279208-4 1982 Upon removal of the nuclei from the system, preincubation with ACh produces a lowering of AChE activity in microsomes. Acetylcholine 63-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 6279208-5 1982 cAMP and cGMP reduce AChE activity of microsomes in a complete system. Cyclic AMP 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 6279208-5 1982 cAMP and cGMP reduce AChE activity of microsomes in a complete system. Cyclic GMP 9-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 6279208-6 1982 The results obtained enable one to consider acetylcholine regulation of microsomal AChE level in nerve cells as a multi-component system. Acetylcholine 44-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 6279208-7 1982 The main component in the system is a direct action of ACh on the synthesis of AChE gene product or on its processing, while the other components (cyclic nucleotides and effect of ACh itself on translation) are elements of correction. Acetylcholine 55-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 6125318-0 1982 Effects of phosphonium and chloroethyl-acetylcholine compounds on schistosome and vertebrate acetylcholinesterase. Phosphoranes 11-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 6125318-0 1982 Effects of phosphonium and chloroethyl-acetylcholine compounds on schistosome and vertebrate acetylcholinesterase. chloroethyl-acetylcholine 27-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 7085778-7 1982 These sugars were also effective in eluting bound brain acetylcholinesterase from ligatin affinity columns. Sugars 6-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 7337858-0 1981 Inhibition of brain acetylcholinesterase activity in songbirds exposed to fenitrothion during aerial spraying of forests. Fenitrothion 74-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 7317044-0 1981 Modification of acetylcholinesterase with N-dansylaziridine. n-dansylaziridine 42-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 6946838-1 1981 The specific modifiers of the carboxylic groups - 1.3-dicyclohexylcarbodiimide (DCC) and 1-cyclohexyl-3-(2-morpholinyl-4-ethyl)carbodiimide methyl-p-toluenesulfonate (CMC) cause irreversible inhibition of acetylcholinesterase from human erythrocytes (AChE) and butyrycholinesterase from horse blood serum (BuChE). carboxylic 30-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 205-225 6946838-1 1981 The specific modifiers of the carboxylic groups - 1.3-dicyclohexylcarbodiimide (DCC) and 1-cyclohexyl-3-(2-morpholinyl-4-ethyl)carbodiimide methyl-p-toluenesulfonate (CMC) cause irreversible inhibition of acetylcholinesterase from human erythrocytes (AChE) and butyrycholinesterase from horse blood serum (BuChE). carboxylic 30-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 251-255 6946838-3 1981 At initial steps of the reaction the irreversible inhibition obeys the kinetics of the pseudo-monomolecular reactions with the following values of bimolecular constants for the rates of DCC and CMC reactions: for AChE - 2.3 +/- 0.19; 5.1 +/- 0.23 M-1 min-1, for BuChE - 1.5 +/- 0.14 and (2.2 +/- 0.21) . Dicyclohexylcarbodiimide 186-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-217 6946838-3 1981 At initial steps of the reaction the irreversible inhibition obeys the kinetics of the pseudo-monomolecular reactions with the following values of bimolecular constants for the rates of DCC and CMC reactions: for AChE - 2.3 +/- 0.19; 5.1 +/- 0.23 M-1 min-1, for BuChE - 1.5 +/- 0.14 and (2.2 +/- 0.21) . cmc 194-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-217 6946838-9 1981 Under AChE modification by CMC at concentrations causing 50 - 70% inhibition, the substrate inhibition constants and the thermal stability of the non-inhibited part of the enzyme are increased. cmc 27-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 7092918-0 1982 Reversible inhibition of acetylcholinesterase by eseroline, an opioid agonist structurally related to physostigmine (eserine) and morphine. Morphine 130-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 7073703-0 1982 Acetylcholinesterase inhibition by the ketone transition state analog phenoxyacetone and 1-halo-3-phenoxy-2-propanones. Ketones 39-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 7073703-0 1982 Acetylcholinesterase inhibition by the ketone transition state analog phenoxyacetone and 1-halo-3-phenoxy-2-propanones. phenoxyacetone 70-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 7073703-0 1982 Acetylcholinesterase inhibition by the ketone transition state analog phenoxyacetone and 1-halo-3-phenoxy-2-propanones. 1-halo-3-phenoxy-2-propanones 89-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 6297513-3 1982 Acetylcholinesterase (AChE) (EC 3.1.1.7) of human brain was inhibited in vitro by paraoxon and DFP. Paraoxon 82-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 6297513-3 1982 Acetylcholinesterase (AChE) (EC 3.1.1.7) of human brain was inhibited in vitro by paraoxon and DFP. Paraoxon 82-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 6297513-4 1982 Using the rate constants of AChE-inhibition and of AChE-synthesis those concentrations of organophosphorus inhibitors were calculated, which in vivo would reduce the steady-state AChE-activity to 20% of normal. organophosphorus 90-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 6297513-4 1982 Using the rate constants of AChE-inhibition and of AChE-synthesis those concentrations of organophosphorus inhibitors were calculated, which in vivo would reduce the steady-state AChE-activity to 20% of normal. organophosphorus 90-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 6297513-4 1982 Using the rate constants of AChE-inhibition and of AChE-synthesis those concentrations of organophosphorus inhibitors were calculated, which in vivo would reduce the steady-state AChE-activity to 20% of normal. organophosphorus 90-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 6297513-8 1982 The effective detoxication time (teff) was determined for different concentrations of paraoxon and DFP and was compared with the time needed by these organophosphate concentrations to inhibit AChE-activity to 12.5% of normal (t1/8). Organophosphates 150-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 7336361-4 1981 Vesicle cholinesterase activity was enriched and had a substrate preference consistent with that of acetylcholinesterase (acetylcholine greater than acetyl-beta-methylcholine greater than butyryl-choline). butyrylcholine 188-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 6790652-0 1981 A definite number of aphidicolin-sensitive cell-cyclic events are required for acetylcholinesterase development in the presumptive muscle cells of the ascidian embryos. Aphidicolin 21-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 7317405-8 1981 However, in hypotonic media (less than 400 mosmol/kg) or in Triton X-100 (0.2% final concentration) acetylcholinesterase activity was markedly higher. Octoxynol 60-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 7310309-5 1981 The time of first AChE occurrence in embryos which had been arrested in the 32-cell stage with cytochalasin was about the same as in normal embryos. Cytochalasins 95-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 7310309-7 1981 Embryos which had been continuously arrested with colchicine could also produce AChE activity at nearly the same time as did normal embryos. Colchicine 50-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 7459300-1 1981 Acetylcholinesterase (AChE) activity in amniotic fluid was assayed directly by a reaction rate method at 30 degrees C using acetylthiocholine iodide as substrate and ethopropazine as a safe "pseudo" cholinesterase inhibitor. acetylthiocholine iodide 124-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 7459300-1 1981 Acetylcholinesterase (AChE) activity in amniotic fluid was assayed directly by a reaction rate method at 30 degrees C using acetylthiocholine iodide as substrate and ethopropazine as a safe "pseudo" cholinesterase inhibitor. acetylthiocholine iodide 124-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 7459300-1 1981 Acetylcholinesterase (AChE) activity in amniotic fluid was assayed directly by a reaction rate method at 30 degrees C using acetylthiocholine iodide as substrate and ethopropazine as a safe "pseudo" cholinesterase inhibitor. profenamine 166-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 7459300-1 1981 Acetylcholinesterase (AChE) activity in amniotic fluid was assayed directly by a reaction rate method at 30 degrees C using acetylthiocholine iodide as substrate and ethopropazine as a safe "pseudo" cholinesterase inhibitor. profenamine 166-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 6783142-2 1981 7,12-Dimethylbenz(a)anthracene, a potent carcinogen, acted as a noncompetitive inhibitor of membrane acetylcholinesterase. 9,10-Dimethyl-1,2-benzanthracene 0-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 6783142-5 1981 Glucose exchange across the membrane was inhibited by the same compounds which inhibit acetylcholinesterase. Glucose 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 6108954-4 1981 In untreated inside-out vesicles, 3.76 +/- 1.44 nmol of calcium/min/unit of acetylcholinesterase were transported, compared with 10.57 +/- 2.05 (+/- S.D. Calcium 56-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 6894279-1 1981 Phosphatidylcholine and phosphatidylserine + phosphatidylcholine liposomes were prepared with cholate and erythrocyte acetylcholinesterase (EC 3.1.1.7). Phosphatidylcholines 0-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 6894279-1 1981 Phosphatidylcholine and phosphatidylserine + phosphatidylcholine liposomes were prepared with cholate and erythrocyte acetylcholinesterase (EC 3.1.1.7). Phosphatidylserines 24-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 6894279-1 1981 Phosphatidylcholine and phosphatidylserine + phosphatidylcholine liposomes were prepared with cholate and erythrocyte acetylcholinesterase (EC 3.1.1.7). Phosphatidylcholines 45-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 6894279-2 1981 Dipalmitoyllecithin- and egg lecithin-acetylcholinesterase complexes exhibit an affinity for acetylthiocholine different from that of the free enzyme. Acetylthiocholine 93-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 6894279-3 1981 The binding to lecithin apparently abolishes the excess substrate inhibition of acetylcholinesterase; the affinity constants of acetylthiocholine, acetylcholine and acetylcarnitine for the lecithin-bound enzymes are higher than the ones found for the free enzyme. Lecithins 15-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 6894279-3 1981 The binding to lecithin apparently abolishes the excess substrate inhibition of acetylcholinesterase; the affinity constants of acetylthiocholine, acetylcholine and acetylcarnitine for the lecithin-bound enzymes are higher than the ones found for the free enzyme. Acetylthiocholine 128-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 6894279-3 1981 The binding to lecithin apparently abolishes the excess substrate inhibition of acetylcholinesterase; the affinity constants of acetylthiocholine, acetylcholine and acetylcarnitine for the lecithin-bound enzymes are higher than the ones found for the free enzyme. Acetylcarnitine 165-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 6894279-3 1981 The binding to lecithin apparently abolishes the excess substrate inhibition of acetylcholinesterase; the affinity constants of acetylthiocholine, acetylcholine and acetylcarnitine for the lecithin-bound enzymes are higher than the ones found for the free enzyme. Lecithins 189-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 6894279-4 1981 Binding to lecithin decrease the optimum pH value for acetylcholinesterase, increase the resistance of the enzyme to heat denaturation and reduces the extent of activation by Ca2+. Lecithins 11-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 20487840-0 1981 Gallamine and tubocurarine as possible allosteric modifiers of soluble acetylcholinesterase activity at physiological ionic strength. Gallamine Triethiodide 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 20487840-0 1981 Gallamine and tubocurarine as possible allosteric modifiers of soluble acetylcholinesterase activity at physiological ionic strength. Tubocurarine 14-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 20487840-1 1981 Esters of dimethylcarbamic acid are known to be poor substrates of acetylcholinesterase. Esters 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 20487840-1 1981 Esters of dimethylcarbamic acid are known to be poor substrates of acetylcholinesterase. N,N-dimethylcarbamate 10-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 20487840-4 1981 Rapid hydrolysis of phosphonylated acetylcholinesterase can be brought about by oximes, but dealkylation of the phosphonyl group on the enzyme (known as ageing) renders the inhibited enzyme insensitive to oximes. Oximes 80-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 20487840-6 1981 Gallamine, d-tubocurarine and alcuronium accelerated reactivation of dimethylcarbamyl-acetylcholinesterase. Gallamine Triethiodide 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 20487840-6 1981 Gallamine, d-tubocurarine and alcuronium accelerated reactivation of dimethylcarbamyl-acetylcholinesterase. Tubocurarine 11-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 20487840-6 1981 Gallamine, d-tubocurarine and alcuronium accelerated reactivation of dimethylcarbamyl-acetylcholinesterase. Alcuronium 30-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 20487840-8 1981 Gallamine and tubocurarine retarded ageing of isopropylmethylphosphonyl-acetylcholinesterase, whereas 3,3-dimethyl-1-butanol had no effect. Gallamine Triethiodide 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 20487840-8 1981 Gallamine and tubocurarine retarded ageing of isopropylmethylphosphonyl-acetylcholinesterase, whereas 3,3-dimethyl-1-butanol had no effect. Tubocurarine 14-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 7234252-1 1981 With the use of quantitative histochemistry and cytochemistry methods the localization of acetylcholinesterase in the brain of man and animals in cases of acute poisoning with organophosphorus compounds was studied. organophosphorus 176-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 7234252-3 1981 In the human brain, the drop of the acetylcholinesterase activity caused by organophosphorus compounds was the most pronounced in the neuropile and the neurons of the cortex, caudate nucleus and hypothalamus. organophosphorus 76-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 6160928-1 1980 The presence of absence of a specific acetylcholinesterase (AChE) band was determined by polyacrylamide gel electrophoresis on 272 second trimester amniotic fluid samples. polyacrylamide 89-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 6161028-0 1980 A simple silver nitrate impregnation of nerve fibres with preservation of acetylcholinesterase activity at the motor end-plate. Silver Nitrate 9-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 6161028-1 1980 A rapid silver nitrate impregnation of nerve fibres has been devised to maintain a histochemically detectable acetylcholinesterase activity at the motor end-plates. Silver Nitrate 8-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 6257542-0 1980 Inhibition of acetylcholinesterase by 3-methoxy catecholamine derivatives. 3-methoxy catecholamine 38-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 7000392-2 1980 The assay is based on inhibition of hydrolysis of the substrate, acetyl-beta-(methylthio)choline iodide, by acetylcholinesterase (acetylcholine hydrolase; EC 3.1.1.7). acetyl-beta-(methylthio)choline iodide 65-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 7000392-3 1980 Thyroxine covalently linked to a cholinesterase inhibitor irreversibly inhibits acetylcholinesterase, but if this thyroxine conjugate is bound to antibody it is not inhibitory. Thyroxine 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 7441241-8 1980 Our results suggest that some nerve soluble substance, other than serum contaminants or 16S AChE itself, affects the maintenance of 16S AChE at the neuromuscular junction. Sulfur 132-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 7441241-8 1980 Our results suggest that some nerve soluble substance, other than serum contaminants or 16S AChE itself, affects the maintenance of 16S AChE at the neuromuscular junction. Sulfur 132-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 6935657-2 1980 In addition, it can be photodecomposed by photoexcited tryptophan derivatives (e.g., N-acetyltryptophanamide and tryptophan residues belonging to acetylcholinesterase) by an energy transfer reaction. Tryptophan 55-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-166 6935657-2 1980 In addition, it can be photodecomposed by photoexcited tryptophan derivatives (e.g., N-acetyltryptophanamide and tryptophan residues belonging to acetylcholinesterase) by an energy transfer reaction. N-acetyltryptophanamide 85-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-166 6935657-2 1980 In addition, it can be photodecomposed by photoexcited tryptophan derivatives (e.g., N-acetyltryptophanamide and tryptophan residues belonging to acetylcholinesterase) by an energy transfer reaction. Tryptophan 93-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-166 6780228-2 1980 Acetylcholine is hydrolysed by acetylcholinesterase; the choline liberated is oxidized by choline oxidase to betaine; the H2O2 generated triggers the luminescence of luminol in presence of peroxidase. Acetylcholine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 6780228-2 1980 Acetylcholine is hydrolysed by acetylcholinesterase; the choline liberated is oxidized by choline oxidase to betaine; the H2O2 generated triggers the luminescence of luminol in presence of peroxidase. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 6780228-2 1980 Acetylcholine is hydrolysed by acetylcholinesterase; the choline liberated is oxidized by choline oxidase to betaine; the H2O2 generated triggers the luminescence of luminol in presence of peroxidase. Betaine 109-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 6780228-2 1980 Acetylcholine is hydrolysed by acetylcholinesterase; the choline liberated is oxidized by choline oxidase to betaine; the H2O2 generated triggers the luminescence of luminol in presence of peroxidase. Hydrogen Peroxide 122-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 6780228-2 1980 Acetylcholine is hydrolysed by acetylcholinesterase; the choline liberated is oxidized by choline oxidase to betaine; the H2O2 generated triggers the luminescence of luminol in presence of peroxidase. Luminol 166-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 7026089-1 1981 Acetylcholinesterase activity in amniotic fluid was measured at 30 degree C by a reaction rate method employing acetyl-beta-methyl thiocholine as substrate and ethopropazine as a selective inhibitor of butyrylcholinesterase. acetyl-beta-(methylthio)choline 112-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 7026089-1 1981 Acetylcholinesterase activity in amniotic fluid was measured at 30 degree C by a reaction rate method employing acetyl-beta-methyl thiocholine as substrate and ethopropazine as a selective inhibitor of butyrylcholinesterase. profenamine 160-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 7256468-9 1981 Clinical recovery (the point at which atropine could safely be discontinued) generally correlated with a recovery of E-AChE activity to 30% or more of normal. Atropine 38-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 7263627-2 1981 Structurally related cationic and uncharged compounds have been studied as inhibitors of hydrolysis by acetylcholinesterase of acetylcholine and its uncharged carbon analog, 3,3-dimethylbutyl acetate. 3,3-dimethylbutylacetate 174-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 7296341-0 1981 Stability of acetylcholinesterase in guanidine hydrochloride solution. Guanidine 37-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-33 7296341-1 1981 The irreversible unfolding of acetylcholinesterase (acetylcholine hydrolyase, EC 3.1.1.7) by guanidine hydrochloride was studied by difference spectral, circular dichroic, and enzyme activity measurements. Guanidine 93-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 7296341-4 1981 Acetylcholinesterase in concentrated guanidine hydrochloride solution containing beta-mercaptoethanol dissociates and exists as a random coil of molecular weight 68 000. Guanidine 37-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 7296341-4 1981 Acetylcholinesterase in concentrated guanidine hydrochloride solution containing beta-mercaptoethanol dissociates and exists as a random coil of molecular weight 68 000. Mercaptoethanol 81-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 6275065-7 1981 When the acetylcholinesterase was inhibited with diisopropylfluorophosphate, neostigmine, or collagenase treatment to prolong the duration of the nerve-released ACh in the synaptic cleft, desensitization developed during repetitive stimulation of 1000 impulses at 5-33 impulses/sec and then recovered after the conditioning trains, with a time constant of about 25 sec.4. Isoflurophate 49-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 6275065-7 1981 When the acetylcholinesterase was inhibited with diisopropylfluorophosphate, neostigmine, or collagenase treatment to prolong the duration of the nerve-released ACh in the synaptic cleft, desensitization developed during repetitive stimulation of 1000 impulses at 5-33 impulses/sec and then recovered after the conditioning trains, with a time constant of about 25 sec.4. Neostigmine 77-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 6275065-7 1981 When the acetylcholinesterase was inhibited with diisopropylfluorophosphate, neostigmine, or collagenase treatment to prolong the duration of the nerve-released ACh in the synaptic cleft, desensitization developed during repetitive stimulation of 1000 impulses at 5-33 impulses/sec and then recovered after the conditioning trains, with a time constant of about 25 sec.4. Acetylcholine 161-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 6275065-8 1981 When the acetylcholinesterase was active so that the duration of ACh in the synaptic cleft resulting from each nerve impulse was brief (< 300 musec), desensitization developed in response to 300-500 pairs of nerve stimuli if the interval between the impulses of each pair was 25 msec or less. Acetylcholine 65-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 7329505-2 1981 The secretion of dopamine (DA), noradrenaline (NA), adrenaline (A) and their precursor--DOPA) as well as the activity of acetylcholinesterase (AChe)--the enzyme disintegrating acetylcholine--were determined. Acetylcholine 121-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 7260096-0 1981 [Accelerating effect of heterocyclic quaternary ammonium salts on neutral ester hydrolysis by acetylcholinesterase and butyrylcholinesterase (author"s transl)]. quaternary ammonium salts 37-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 7260096-0 1981 [Accelerating effect of heterocyclic quaternary ammonium salts on neutral ester hydrolysis by acetylcholinesterase and butyrylcholinesterase (author"s transl)]. Esters 74-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 7260096-1 1981 Some heterocyclic cations (1-methylacridinium, 1-methyl-2-hydroxyiminomethylpyridinium and 1-methyl-3-methoxy-pyridinium) cause acceleration of hydrolysis of alkyl acetates (methyl, ethyl or n-propyl acetate) by acetylcholinesterase (acetylcholine acetylhydrolase EC 3.1.1.7) (Barnett, P. and Rosenberry, T.L. 1-methylacridinium 27-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 212-232 7260096-1 1981 Some heterocyclic cations (1-methylacridinium, 1-methyl-2-hydroxyiminomethylpyridinium and 1-methyl-3-methoxy-pyridinium) cause acceleration of hydrolysis of alkyl acetates (methyl, ethyl or n-propyl acetate) by acetylcholinesterase (acetylcholine acetylhydrolase EC 3.1.1.7) (Barnett, P. and Rosenberry, T.L. 1-methyl-2-hydroxyiminomethylpyridinium 47-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 212-232 7260096-1 1981 Some heterocyclic cations (1-methylacridinium, 1-methyl-2-hydroxyiminomethylpyridinium and 1-methyl-3-methoxy-pyridinium) cause acceleration of hydrolysis of alkyl acetates (methyl, ethyl or n-propyl acetate) by acetylcholinesterase (acetylcholine acetylhydrolase EC 3.1.1.7) (Barnett, P. and Rosenberry, T.L. 1-methyl-3-methoxy-pyridinium 91-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 212-232 7260096-1 1981 Some heterocyclic cations (1-methylacridinium, 1-methyl-2-hydroxyiminomethylpyridinium and 1-methyl-3-methoxy-pyridinium) cause acceleration of hydrolysis of alkyl acetates (methyl, ethyl or n-propyl acetate) by acetylcholinesterase (acetylcholine acetylhydrolase EC 3.1.1.7) (Barnett, P. and Rosenberry, T.L. alkyl acetates 158-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 212-232 7260096-1 1981 Some heterocyclic cations (1-methylacridinium, 1-methyl-2-hydroxyiminomethylpyridinium and 1-methyl-3-methoxy-pyridinium) cause acceleration of hydrolysis of alkyl acetates (methyl, ethyl or n-propyl acetate) by acetylcholinesterase (acetylcholine acetylhydrolase EC 3.1.1.7) (Barnett, P. and Rosenberry, T.L. ethyl or n-propyl acetate 182-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 212-232 6166979-5 1981 After exposure to colchicine it could be shown that the VIP and SP containing nerve cell bodies also were positive for AChE. Colchicine 18-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 7252129-2 1981 The model is an artificial proteic membrane in which acetylcholinesterase homogeneously is immobilized chemically by a bifunctional agent, glutaraldehyde. Glutaral 139-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 6266109-4 1981 The obtained results seem to suggest that the changes in the native conformation of membrane catalytic proteins resulted from cryodamage are responsible for the lowered aChE activity; the primary cause of increase Na+, K+-ATPase activity is due to the changes in the permeability and integrity of erythrocyte membrane, which are followed by the greater accessibility of the substrate (ATP) to the enzyme. Adenosine Triphosphate 222-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 7315401-4 1981 The dissociation constant of the crude enzyme-edrophonium complex determined in the affinity chromatographic experiments was 1.5 X 10(-5) M and in enzymatic experiments 1.8 X 10(-7) M. It is proposed that there is present in mammalian neuronal tissue a factor that increases the affinity of certain cholinergic ligands to a site other than the catalytic site on AChE. Edrophonium 46-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 362-366 7217205-10 1981 As in the normal SCG, physostigmine-resistant staining, caused by noncholinesterase enzymes plus the possible presence of very low concentrations of AChE or BuChE, was noted at external mitochondrial membranes, elements of the endoplasmic reticulum of neurites and Schwann cells, and also in lysosomes. Physostigmine 22-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 7256355-1 1981 The antimalarial agent, amodiaquine, is a potent inhibitor of AChE (Ki = 1.50 x 10(-9) M, pH 7.4, 25 degrees C). Amodiaquine 24-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 7256355-2 1981 Both the protonated diethylamino and phenolic hydroxyl functions of amodiaquine are necessary for interaction with AChE. diethylamino 20-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 7256355-2 1981 Both the protonated diethylamino and phenolic hydroxyl functions of amodiaquine are necessary for interaction with AChE. Hydroxyl Radical 46-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 7256355-2 1981 Both the protonated diethylamino and phenolic hydroxyl functions of amodiaquine are necessary for interaction with AChE. Amodiaquine 68-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 7256355-3 1981 This suggests that the inhibition of AChE by amodiaquine may involve binding of the protonated diethylamino and phenolic hydroxyl functions to the anionic and esteric sites of the enzyme respectively. Amodiaquine 45-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 7256355-3 1981 This suggests that the inhibition of AChE by amodiaquine may involve binding of the protonated diethylamino and phenolic hydroxyl functions to the anionic and esteric sites of the enzyme respectively. diethylamino 95-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 7256355-3 1981 This suggests that the inhibition of AChE by amodiaquine may involve binding of the protonated diethylamino and phenolic hydroxyl functions to the anionic and esteric sites of the enzyme respectively. Hydroxyl Radical 121-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 7256355-4 1981 The anti-AChE property of amodiaquine may be related in some way to the gastrointestinal and central nervous system disturbances frequently encountered when large doses of amodiaquine are used for the treatment of malaria. Amodiaquine 26-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 7256355-4 1981 The anti-AChE property of amodiaquine may be related in some way to the gastrointestinal and central nervous system disturbances frequently encountered when large doses of amodiaquine are used for the treatment of malaria. Amodiaquine 172-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 6166656-8 1981 The high AChE content in some of the cortical neurons that also showed GABA uptake indicates that there are at least two distinct types of GABAergic neurons. gamma-Aminobutyric Acid 71-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 6790652-3 1981 The 64-cell-stage embryos which had been permanently cleavage-arrested with cytochalasin B developed AChE in all the eight presumptive muscle cells, but the same stage embryos which had been prevented from undergoing further divisions by simultaneous treatment with aphidicolin and cytochalasin did not produce AChE at all. Cytochalasins 76-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 6790652-4 1981 Cytochalasin-arrested 76-cell-stage embryos were able to differentiate AChE in the ten presumptive muscle cells, while aphidicolin-cytochalasin-arrested 76-cell stages in as many as four cells. Cytochalasins 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 6790652-5 1981 The early gastrulae which had been arrested with cytochalasin B produced AChE in all the sixteen presumptive muscle cells, while the same stage embryos arrested with aphidicolin and cytochalasin in as many as twelve cells. Cytochalasin B 49-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 6790652-5 1981 The early gastrulae which had been arrested with cytochalasin B produced AChE in all the sixteen presumptive muscle cells, while the same stage embryos arrested with aphidicolin and cytochalasin in as many as twelve cells. Cytochalasins 49-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 6790652-6 1981 Cytochalasin-arrested late gastrulae developed AChE in twenty blastomeres, while aphidicolin-cytochalasin-arrested late gastrulae in eighteen cells. Cytochalasins 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 6790652-8 1981 Judging from the relative positions of the blastomeres, the AChE-producing cells in aphidicolin-cytochalasin-arrested embryos were always at eighth or ninth generation, while those with no AChE activity were certainly at seventh generation. Aphidicolin 84-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 6790652-9 1981 Based on these findings it was supposed that aphidicolin-sensitive cell-cycle events, presumably DNA replication, are closely associated with AChE development and that the eighth cleavage cycle may be "quantal" for the histospecific enzyme development. Aphidicolin 45-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 7459107-2 1980 The recovery of enzymatic activity when AChE wa solubilized by means of freezing and thawing followed by treatment with 0,5% Triton X-100, represented approximately 95% of the total erythricytic activity for both human and rat preparations. Octoxynol 125-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 6790652-3 1981 The 64-cell-stage embryos which had been permanently cleavage-arrested with cytochalasin B developed AChE in all the eight presumptive muscle cells, but the same stage embryos which had been prevented from undergoing further divisions by simultaneous treatment with aphidicolin and cytochalasin did not produce AChE at all. Cytochalasin B 76-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 7407159-7 1980 Mainly dimeric acetylcholinesterase was found when the reconstituted or, alternatively, the lipid-free but Triton-solubilized enzyme were cross-linked with glutaraldehyde. Glutaral 156-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 7450218-0 1980 The release of acetylcholinesterase from human erythrocytes by sodium taurocholate. Taurocholic Acid 63-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 7426043-0 1980 Reactivation of acetylcholinesterase inhibited by 1,2,2"-trimethylpropyl methylphosphonofluoridate (soman) with HI-6 and related oximes. Soman 50-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 7426043-0 1980 Reactivation of acetylcholinesterase inhibited by 1,2,2"-trimethylpropyl methylphosphonofluoridate (soman) with HI-6 and related oximes. Soman 100-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 7426043-0 1980 Reactivation of acetylcholinesterase inhibited by 1,2,2"-trimethylpropyl methylphosphonofluoridate (soman) with HI-6 and related oximes. asoxime chloride 112-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 7426043-0 1980 Reactivation of acetylcholinesterase inhibited by 1,2,2"-trimethylpropyl methylphosphonofluoridate (soman) with HI-6 and related oximes. Oximes 129-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 7460914-9 1980 Apart from inhibition by serotonin and acetylcholine the purified aryl acylamidases from all the three sources were potently inhibited by neostygmine, eserine and BW 284C51, all strong inhibitors of acetylcholinesterase. neostygmine 138-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-219 7402075-1 1980 Endogenous cholinergic stimulation, produced by the intravenous injection of edrophonium (10 mg), an acetylcholinesterase inhibitor, into 8 normal human subjects, resulted in an increase in the mean (+/- SE) serum growth hormone (GH) concentration from 0.6 +/- 0.1 ng/ml to 5.6 +/- 1.4 ng/ml (p < 0.01) at 40 min with no changes in serum prolactin. Edrophonium 77-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 6249683-0 1980 Induction of neural-like cells and acetylcholinesterase activity in cultures of F9 teratocarcinoma treated with retinoic acid and dibutyryl cyclic adenosine monophosphate. Tretinoin 112-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 7422060-1 1980 The acetylcholinesterase from synaptosomal membranes is inhibited by anesthetics: Nembutal, brietal, and thiopental. Pentobarbital 82-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 7422060-1 1980 The acetylcholinesterase from synaptosomal membranes is inhibited by anesthetics: Nembutal, brietal, and thiopental. Thiopental 105-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 6249683-0 1980 Induction of neural-like cells and acetylcholinesterase activity in cultures of F9 teratocarcinoma treated with retinoic acid and dibutyryl cyclic adenosine monophosphate. Bucladesine 130-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 7465080-0 1980 [Propanidid as an antagonist: competitive inhibitor of neuromuscular plaque acetylcholinesterase]. Propanidid 1-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-97 7398650-6 1980 The reconstitution process impaired the allosteric transition of acetylcholinesterase which is thought to occur when Flaxedil (gallamine triethiodide) is present in a low ionic strength medium. Gallamine Triethiodide 117-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 7398650-6 1980 The reconstitution process impaired the allosteric transition of acetylcholinesterase which is thought to occur when Flaxedil (gallamine triethiodide) is present in a low ionic strength medium. Gallamine Triethiodide 127-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 6160210-3 1980 When the NBT stain was combined with the Karnovsky acetylcholinesterase (AChE) procedure the blue-coloured nerve terminal processes were vividly outlined by the brown copper ferrocyanide-AChE reaction product. Nitroblue Tetrazolium 9-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 6160210-3 1980 When the NBT stain was combined with the Karnovsky acetylcholinesterase (AChE) procedure the blue-coloured nerve terminal processes were vividly outlined by the brown copper ferrocyanide-AChE reaction product. Nitroblue Tetrazolium 9-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 6160210-3 1980 When the NBT stain was combined with the Karnovsky acetylcholinesterase (AChE) procedure the blue-coloured nerve terminal processes were vividly outlined by the brown copper ferrocyanide-AChE reaction product. cupric ferrocyanide 167-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 6160210-3 1980 When the NBT stain was combined with the Karnovsky acetylcholinesterase (AChE) procedure the blue-coloured nerve terminal processes were vividly outlined by the brown copper ferrocyanide-AChE reaction product. cupric ferrocyanide 167-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 6160210-9 1980 The powerful experimental advantage of the NBT-AChE stain for neuromuscular junctions resulted from the sharp colour contrast which made possible accurate determinations of the relationship between the presynaptic nerve terminal arborization and the postsynaptic junctional AChE activity. Nitroblue Tetrazolium 43-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 6160210-9 1980 The powerful experimental advantage of the NBT-AChE stain for neuromuscular junctions resulted from the sharp colour contrast which made possible accurate determinations of the relationship between the presynaptic nerve terminal arborization and the postsynaptic junctional AChE activity. Nitroblue Tetrazolium 43-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 274-278 6160211-2 1980 Presynaptic nerve terminals and postsynaptic acetylcholinesterase (AChE) activity simultaneously demonstrated at these developing junctions using the NBT-AChE method. Nitroblue Tetrazolium 150-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 6160211-2 1980 Presynaptic nerve terminals and postsynaptic acetylcholinesterase (AChE) activity simultaneously demonstrated at these developing junctions using the NBT-AChE method. Nitroblue Tetrazolium 150-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-158 7465080-1 1980 Propanidid is a competitive inhibitor not only of serum cholinesterase, but of neuromuscular plaque and brain acetylcholinesterase also. Propanidid 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 7465080-2 1980 The I50 of plaque acetylcholinesterase occurs at much higher concentrations of anaesthetic than for serum enzyme, this may depend on the environmental conditions under which propanidide has to act, or on acetylcholinesterase"s high degree of specificity by comparison with pseudocholinesterase. Propanidid 174-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 7465080-2 1980 The I50 of plaque acetylcholinesterase occurs at much higher concentrations of anaesthetic than for serum enzyme, this may depend on the environmental conditions under which propanidide has to act, or on acetylcholinesterase"s high degree of specificity by comparison with pseudocholinesterase. Propanidid 174-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-224 6929531-1 1980 Ultraviolet irradiation of 11S acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7) produces a loss of tryptophan fluorescence which is best described as the sum of two separable first-order processes, one much more rapid than the other. Tryptophan 115-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 7391411-0 1980 Inhibition of acetylcholinesterase by O-(methylcarbamoyl)oximes. o-(methylcarbamoyl)oximes 38-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 7370307-1 1980 Comparative assays were made in a spectrophotometer and a microcalorimeter for the reaction between acetylcholinesterase (EC 3.1.1.7) and acetylthiocholine. Acetylthiocholine 138-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 7396501-0 1980 The susceptibility of red cell acetylcholinesterase to radiation-induced free radicals. Free Radicals 73-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 7368161-2 1980 Three different anticholinesteratic agents (eserine, neostigmine, and diisopropylphosphorofluoridate) at final concentrations of 10 muM caused complete inhibition of AChE activity after 30 min incubation at room temperature with either platelet-rich plasma or gel-filtered platelets. Neostigmine 53-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 7396669-0 1980 [Structure- and conformation-activity relationships of cyclic acetylcholine analogues, XI: acetylcholinesterase- and base-catalyzed hydrolysis of derivatives of 3-acetoxypiperidine and 3-acetoxythiacyclohexane (author"s transl)]. cyclic acetylcholine 55-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 7396669-0 1980 [Structure- and conformation-activity relationships of cyclic acetylcholine analogues, XI: acetylcholinesterase- and base-catalyzed hydrolysis of derivatives of 3-acetoxypiperidine and 3-acetoxythiacyclohexane (author"s transl)]. 3-acetoxypiperidine 161-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 7396669-0 1980 [Structure- and conformation-activity relationships of cyclic acetylcholine analogues, XI: acetylcholinesterase- and base-catalyzed hydrolysis of derivatives of 3-acetoxypiperidine and 3-acetoxythiacyclohexane (author"s transl)]. 3-Acetoxythiacyclohexane 185-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 7368161-2 1980 Three different anticholinesteratic agents (eserine, neostigmine, and diisopropylphosphorofluoridate) at final concentrations of 10 muM caused complete inhibition of AChE activity after 30 min incubation at room temperature with either platelet-rich plasma or gel-filtered platelets. Isoflurophate 70-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 6248079-0 1980 The effect of the steroid muscle relaxant pipecurium bromide on the acetylcholinesterase activity of red blood cells in vitro. Steroids 18-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 6247039-2 1980 Thus far, evidence suggests that the only possible action of endogenous acetylcholine (ACh) present near noradrenaline (NA) stores is an inhibition of the release of NA from the adrenergic nerve terminals and that NA is released only when the action of acetylcholinesterase is inhibited. Acetylcholine 72-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 253-273 6247039-2 1980 Thus far, evidence suggests that the only possible action of endogenous acetylcholine (ACh) present near noradrenaline (NA) stores is an inhibition of the release of NA from the adrenergic nerve terminals and that NA is released only when the action of acetylcholinesterase is inhibited. Acetylcholine 87-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 253-273 7364202-0 1980 Interactions of the cholinergic and serotonergic systems: re-evaluation of conditions for inhibition of acetylcholinesterase by serotonin and evidence for a new inhibitor derived from this natural indoleamine. Serotonin 128-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 7399577-0 1980 Acetylcholinesterase activity in the red blood cells of pregnant women & their foetus. Adenosine Monophosphate 72-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 20487783-2 1980 The relationship of this theory to the inhibition of acetylcholinesterase by organophosphates is emphasized. Organophosphates 77-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 514364-6 1979 Although acetylcholinesterase (AChE) is present in migrating neural crest, choline acetyltransferase (CAT), the enzyme catalysing acetylcholine (ACh) synthesis, is a much more relevant correlate, and definitive evidence for cholinergic differentiation should include the demonstration of ACh-synthesising activity in intact cells or their extracts. Acetylcholine 9-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 508861-0 1979 [Inhibitory effect of verapamil on the acetylcholinesterase activity of skeletal muscle sarcolemma]. Verapamil 22-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 508861-1 1979 It has been found that verapamil reversibly inhibits "in vitro" the activity of membrane--bound and solubilized sarcolemmal acetylcholinesterase. Verapamil 23-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 508861-4 1979 The effect of vereapamil and Ca2+ on acetylcholinesterase is independent and non-competitive. vereapamil 14-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 508861-5 1979 An increase in the ionic strength leads to a decrease of the verapamil-induced inhibition of acetylcholinesterase. Verapamil 61-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 540236-0 1979 Kinetics of acetylcholinesterase immobilized on polyethylene tubing. Polyethylene 48-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 540236-1 1979 Acetylcholinesterase was covalently attached to the inner surface of polyethylene tubing. Polyethylene 69-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 6248079-0 1980 The effect of the steroid muscle relaxant pipecurium bromide on the acetylcholinesterase activity of red blood cells in vitro. Pipecuronium 42-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 6248079-6 1980 Pipecurium bromide showed mixed-type inhibitory effect both on AchE and ChE. Pipecuronium 0-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 229216-7 1979 frequency but ambenonium, with a high specificity for acetylcholinesterase, was markedly less effective in this respect. Ambenonium Chloride 14-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 486700-0 1979 Inhibition of acetylcholinesterase by TX-100. polyethylene glycol monooctylphenyl ether 38-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 486700-1 1979 At high detergent concentrations, approximately the equivalent of 2 micelles of TX-100 reversibly bind to acetylcholinesterase and fully inhibit the enzyme. polyethylene glycol monooctylphenyl ether 80-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 530484-1 1979 In the same brain section stained first for catecholamines and then for acetylcholinesterase (EC 3.1.1.7), it was found that neuronal somata in locus ceruleus containing norepinephrine also contained the cholinergic degradative enzyme. Norepinephrine 170-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 497002-0 1979 Some adjuncts to oxime-atropine therapy for organophosphate intoxication--their effects on acetylcholinesterase. Oximes 17-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 497002-0 1979 Some adjuncts to oxime-atropine therapy for organophosphate intoxication--their effects on acetylcholinesterase. Atropine 23-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 497002-0 1979 Some adjuncts to oxime-atropine therapy for organophosphate intoxication--their effects on acetylcholinesterase. Organophosphates 44-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 488916-0 1979 Molecular forms of purified human erythrocyte membrane acetylcholinesterase investigated by crosslinking with diimidates. diimidates 110-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 488916-1 1979 Several molecular forms of human erythrocyte membrane acetylcholinesterase have been studied after crosslinking with bifunctional diimidates. diimidates 130-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 488916-4 1979 It was shown that acetylcholinesterase crosslinked in absence of Triton X-100 consists of molecular forms built up by dimeric protomers. Octoxynol 65-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 30781917-2 1979 Three different anticholinesteratic agents (eserine, neostigmine, and diiso- propylphosphorofluoridate) at final concentrations of 10 muM caused complete inhibition of AChE activity after 30 min incubation at room temperature with either platelet-rich plasma or gel-filtered platelets. Neostigmine 53-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-172 30781917-2 1979 Three different anticholinesteratic agents (eserine, neostigmine, and diiso- propylphosphorofluoridate) at final concentrations of 10 muM caused complete inhibition of AChE activity after 30 min incubation at room temperature with either platelet-rich plasma or gel-filtered platelets. Isoflurophate 70-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-172 110344-2 1979 2-Methyldimethylaminoazobenzene is a more potent inhibitor of acetylcholinesterase than the 3"-methyl analogue, while the unsubstituted compound fails to inhibit. 2-methyldimethylaminoazobenzene 0-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 437177-0 1979 [Interaction of DOPA with blood acetylcholinesterase in parkinsonism]. Dihydroxyphenylalanine 16-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 222070-2 1979 The Km value of acetylcholinesterase for acetyl thiocholine was not altered in the reaction and the enzyme proved to be more resistant to heat denaturation. Acetylthiocholine 41-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 444532-0 1979 Fluorinated aldehydes and ketones acting as quasi-substrate inhibitors of acetylcholinesterase. fluorinated aldehydes 0-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 444532-0 1979 Fluorinated aldehydes and ketones acting as quasi-substrate inhibitors of acetylcholinesterase. Ketones 26-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 444532-6 1979 3. m-N,N,N-Trimethylammonium-acetophenone acts as a rapid and reversible, time-independent, linear competitive inhibitor of acetylcholinesterase (Ki = 5.0 . n,n,n-trimethylammonium-acetophenone 5-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 436301-2 1979 Total AChE activity was increased in Hirsprung"s disease; the activity was separated by polyacrylamide gel electrophoresis into two molecular forms. polyacrylamide 88-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 530484-5 1979 Acetylcholinesterase may be associated with cerulear somata and proximal processes containing norepinephrine to inactivate a cholinergic input to that structure. Norepinephrine 94-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 215229-0 1979 Labeling of human erythrocyte membranes with eosin probes used for protein diffusion measurements: inhibition of anion transport and photo-oxidative inactivation of acetylcholinesterase. Eosine Yellowish-(YS) 45-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-185 427042-3 1979 These results and that from comparison of activation of deoxycholate-extracted enzyme by lipids from normal erythrocytes suggest that the low acetylcholinesterase activity in PNH erythrocytes is due, at least in part, to alteration in the lipid environment of the enzyme. Deoxycholic Acid 56-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 435080-5 1979 The oximes with a hydroxyiminomethyl group in position 4 in the pyridinium ring were good reactivators of both phosphorylated and phosphonylated acetylcholinesterase. Oximes 4-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 435080-5 1979 The oximes with a hydroxyiminomethyl group in position 4 in the pyridinium ring were good reactivators of both phosphorylated and phosphonylated acetylcholinesterase. pyridine 64-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 215229-8 1979 Both eosin derivatives, however, inactivate acetylcholinesterase upon illumination of air-equilibrated samples of hemoglobin-free labeled ghosts. Eosine Yellowish-(YS) 5-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 93746-8 1979 Illumination of eosin-labeled ghosts causes a rapid loss of acetylcholinesterase activity but this can be prevented by prior displacement of oxygen in the sample by argon. Eosine Yellowish-(YS) 16-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 435550-1 1979 Data are presented in favour of the regulatory role of AChE in passive transmembrane transfer of anions: 1) gradual inhibition of the enzyme with proserin brings about the change of the transport activation energy and irregular shift of temperature in the salient point on Arrhenius curves; 2) complexing of different AChE inhibitors (succinyl cholinechlorine, tetraethyl ammonium, tetramethyl ammonium, d-tubocurarin, proserin) results in the change of transport velocity. succinyl cholinechlorine 335-359 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 435550-1 1979 Data are presented in favour of the regulatory role of AChE in passive transmembrane transfer of anions: 1) gradual inhibition of the enzyme with proserin brings about the change of the transport activation energy and irregular shift of temperature in the salient point on Arrhenius curves; 2) complexing of different AChE inhibitors (succinyl cholinechlorine, tetraethyl ammonium, tetramethyl ammonium, d-tubocurarin, proserin) results in the change of transport velocity. Tetraethylammonium 361-380 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 435550-1 1979 Data are presented in favour of the regulatory role of AChE in passive transmembrane transfer of anions: 1) gradual inhibition of the enzyme with proserin brings about the change of the transport activation energy and irregular shift of temperature in the salient point on Arrhenius curves; 2) complexing of different AChE inhibitors (succinyl cholinechlorine, tetraethyl ammonium, tetramethyl ammonium, d-tubocurarin, proserin) results in the change of transport velocity. tetramethylammonium 382-402 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 435550-1 1979 Data are presented in favour of the regulatory role of AChE in passive transmembrane transfer of anions: 1) gradual inhibition of the enzyme with proserin brings about the change of the transport activation energy and irregular shift of temperature in the salient point on Arrhenius curves; 2) complexing of different AChE inhibitors (succinyl cholinechlorine, tetraethyl ammonium, tetramethyl ammonium, d-tubocurarin, proserin) results in the change of transport velocity. d-tubocurarin 404-417 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 435550-1 1979 Data are presented in favour of the regulatory role of AChE in passive transmembrane transfer of anions: 1) gradual inhibition of the enzyme with proserin brings about the change of the transport activation energy and irregular shift of temperature in the salient point on Arrhenius curves; 2) complexing of different AChE inhibitors (succinyl cholinechlorine, tetraethyl ammonium, tetramethyl ammonium, d-tubocurarin, proserin) results in the change of transport velocity. Neostigmine methyl sulfate 146-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 435550-1 1979 Data are presented in favour of the regulatory role of AChE in passive transmembrane transfer of anions: 1) gradual inhibition of the enzyme with proserin brings about the change of the transport activation energy and irregular shift of temperature in the salient point on Arrhenius curves; 2) complexing of different AChE inhibitors (succinyl cholinechlorine, tetraethyl ammonium, tetramethyl ammonium, d-tubocurarin, proserin) results in the change of transport velocity. Neostigmine methyl sulfate 146-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 318-322 435550-2 1979 A significant increase of membrane binding of highly efficient and specific inhibitor of SITS anion transport forming complexes with membrane transport sites under the effect of acetylcholine AChE substrate is recorded. Acetylcholine 178-191 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 435550-4 1979 The removal of acetylcholine effect which activates SITS binding with the AChE inhibitor points to the initiation of structural disturbances from this enzyme. Acetylcholine 15-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 93746-8 1979 Illumination of eosin-labeled ghosts causes a rapid loss of acetylcholinesterase activity but this can be prevented by prior displacement of oxygen in the sample by argon. Oxygen 141-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 93746-8 1979 Illumination of eosin-labeled ghosts causes a rapid loss of acetylcholinesterase activity but this can be prevented by prior displacement of oxygen in the sample by argon. Argon 165-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 748338-2 1978 The enzyme proved to be acetylcholinesterase (AChE) since acetylthiocholine was the preferred substrate, and eserine or BW284C5I inhibited the enzyme activity, while isoOMPA was without effect. Acetylthiocholine 58-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 748338-2 1978 The enzyme proved to be acetylcholinesterase (AChE) since acetylthiocholine was the preferred substrate, and eserine or BW284C5I inhibited the enzyme activity, while isoOMPA was without effect. Acetylthiocholine 58-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 748338-2 1978 The enzyme proved to be acetylcholinesterase (AChE) since acetylthiocholine was the preferred substrate, and eserine or BW284C5I inhibited the enzyme activity, while isoOMPA was without effect. bw284c5i 120-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 748338-2 1978 The enzyme proved to be acetylcholinesterase (AChE) since acetylthiocholine was the preferred substrate, and eserine or BW284C5I inhibited the enzyme activity, while isoOMPA was without effect. bw284c5i 120-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 748338-4 1978 A fraction 8-fold enriched in AChE was isolated from pooled ventricles by a combination of differential and sucrose density gradient centrifugation. Sucrose 108-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 736567-0 1978 Acetylcholinesterase: differential affinity chromatographic purification of 11 S and 18 S plus 14 S forms; the importance of multiple-site interactions and salt concentration. Salts 156-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 719292-0 1978 Motor output to flight muscles and inhibition of acetylcholinesterase after injection of dimethoate into locusts [proceedings]. Dimethoate 89-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 177158-8 1975 It is concluded that acetylcholinesterase (EC 3.1.1.7) of red cells rapidly hydrolyzes acetylcholine mustard aziridinium ion to acetate and choline mustard aziridinium and the latter compound can act as a potent inhibitor of choline transport. aziridinium 109-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 580736-0 1978 The diagnosis of organophosphorus fatal intoxication by the AChE activity in CSF. organophosphorus 17-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 580736-1 1978 A preliminary test for the diagnosis of intoxications with organophosphorous pesticides in fatal cases is described, based on the fact that these compounds inhibit AChE activity. organophosphorous 59-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 580736-2 1978 For this purpose we measured AChE activity in CSF in 30 samples from fresh bodies autopsied after traffic accidents and in six after poisoning with organophosphorous insecticides. organophosphorous 148-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 565804-0 1978 Carbamylation and decarbamylation of acetylcholinesterase: effect of choline, 3,3-dimethyl-1-butanol and some allosteric effectors. 3,3-dimethylbutan-1-ol 78-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 582677-0 1978 The effect of acetylsalicylic acid/salicylic acid mixtures on acetylcholinesterase activity in vitro. Aspirin 14-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 582677-0 1978 The effect of acetylsalicylic acid/salicylic acid mixtures on acetylcholinesterase activity in vitro. Salicylic Acid 20-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 623848-0 1978 [Effect of Triton X-100 on properties of acetylcholinesterase from human erythrocytes]. Octoxynol 11-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 623848-1 1978 The effect of Triton X-100 on catalytic properties of acetylcholinesterase from human erythrocytes under acetylcholine hydrolysis, on sensitivity of acetylcholinesterase to specific phosphoorganic inhibitors and eserine, and on the mobility and isoenyme spectrum under analytical electrophoresis in polyacrylamide gel is investigated. Octoxynol 14-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 623848-1 1978 The effect of Triton X-100 on catalytic properties of acetylcholinesterase from human erythrocytes under acetylcholine hydrolysis, on sensitivity of acetylcholinesterase to specific phosphoorganic inhibitors and eserine, and on the mobility and isoenyme spectrum under analytical electrophoresis in polyacrylamide gel is investigated. Acetylcholine 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-169 623848-3 1978 The inhibitory effect of Triton X-100 is mainly competitive, 0.5% Triton X-100 decreases bimolecular constant (kII) of the interaction of acetylcholinesterase with phosphoorganic inhibitor and eserine in 2.5-4 times. Octoxynol 25-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 623848-3 1978 The inhibitory effect of Triton X-100 is mainly competitive, 0.5% Triton X-100 decreases bimolecular constant (kII) of the interaction of acetylcholinesterase with phosphoorganic inhibitor and eserine in 2.5-4 times. Octoxynol 66-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 623848-6 1978 The introduction of 0.1% Triton X-100 into polyacrylamide gel results in considerable quantitative redistribution of acetylcholinesterase isoenzyme fractions and in the change of the mobility of one fraction under electrophoresis. Octoxynol 25-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 623848-6 1978 The introduction of 0.1% Triton X-100 into polyacrylamide gel results in considerable quantitative redistribution of acetylcholinesterase isoenzyme fractions and in the change of the mobility of one fraction under electrophoresis. polyacrylamide 43-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 720202-0 1978 [Reaction of N-[beta-(dialkoxyphosphinyl)-mercaptoethyl]anabasines and their diiodomethylates with human erythrocyte acetylcholinesterase and horse serum butyrylcholinesterase]. n-[beta-(dialkoxyphosphinyl)-mercaptoethyl]anabasines 13-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 710696-0 1978 Coupling of acetylcholinesterase to activated nylon nets. Nylons 46-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 603636-0 1977 The arrangement of substrate and organophosphorus-inhibitor leaving groups in acetylcholinesterase active site. organophosphorus 33-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 588302-0 1977 The role of hydrophobic and electron donor properties in acetylcholinesterase inhibition by carbamates. Carbamates 92-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 20999-1 1977 In the presence of organophosphorus inhibitors (OPI) AChE inhibition is initiated at a lower concentration of ACh; the plot reaction rate versus substrate concentration shows two maxima with a distinct minimum between them. organophosphorus 19-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 20999-1 1977 In the presence of organophosphorus inhibitors (OPI) AChE inhibition is initiated at a lower concentration of ACh; the plot reaction rate versus substrate concentration shows two maxima with a distinct minimum between them. Pantothenyl-Aminoethanol-11-Pivalic Acid 48-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 17496-1 1977 A method is described for the assay of acetylcholinesterase in tissue samples using the selective cholinesterase inhibitor, lysivane (10-(alpha-diethylaminopropyl) phenothiazine hydrochloride). profenamine 124-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 17496-1 1977 A method is described for the assay of acetylcholinesterase in tissue samples using the selective cholinesterase inhibitor, lysivane (10-(alpha-diethylaminopropyl) phenothiazine hydrochloride). 10-(alpha-diethylaminopropyl) phenothiazine hydrochloride 134-191 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 19604976-1 1977 In order to study the turnover rate of motor endplate acetylcholinesterase (AChE), we have treated hypoglassal nerve with 10 mM colchine, a drug that produced a reversible decrease of AChE from geniohyoid muscle endplates. (R/S)-Colchicine 128-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 19604976-1 1977 In order to study the turnover rate of motor endplate acetylcholinesterase (AChE), we have treated hypoglassal nerve with 10 mM colchine, a drug that produced a reversible decrease of AChE from geniohyoid muscle endplates. (R/S)-Colchicine 128-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 19604976-1 1977 In order to study the turnover rate of motor endplate acetylcholinesterase (AChE), we have treated hypoglassal nerve with 10 mM colchine, a drug that produced a reversible decrease of AChE from geniohyoid muscle endplates. (R/S)-Colchicine 128-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-188 855909-2 1977 The inhibition by pancuronium of acetylcholinesterase (AChE) and of plasma cholinesterase (ChE) was investigated in vitro regarding a) the sensitivity of both enzymes; b) the mechanism and constants of inhibition; and c) the relationship between the neuromuscular blocking and the anticholinesterase activity of pancuronium. Pancuronium 18-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 855909-2 1977 The inhibition by pancuronium of acetylcholinesterase (AChE) and of plasma cholinesterase (ChE) was investigated in vitro regarding a) the sensitivity of both enzymes; b) the mechanism and constants of inhibition; and c) the relationship between the neuromuscular blocking and the anticholinesterase activity of pancuronium. Pancuronium 18-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 855909-4 1977 Pancuronium is a reversible inhibitor of both AChE and ChE. Pancuronium 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 855909-9 1977 The inhibition of AChE and ChE is thought to be induced by a reversible binding of pancuronium to the anionic subsite of the active center, thus decreasing the formation of the primary enzyme-substrate complex. Pancuronium 83-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 409034-5 1977 However, both DP- and NAC-treated cells showed a similar sensitivity to lysis by acid serum and about the same degree of acetylcholinesterase (AChE) activity decrease, thus indicating that the susceptibility to autoxidation of lipids is not involved in the determination of complement sensitivity or in the AChE activity decrease of the sulfydryl-treated cells. Penicillamine 14-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 409034-5 1977 However, both DP- and NAC-treated cells showed a similar sensitivity to lysis by acid serum and about the same degree of acetylcholinesterase (AChE) activity decrease, thus indicating that the susceptibility to autoxidation of lipids is not involved in the determination of complement sensitivity or in the AChE activity decrease of the sulfydryl-treated cells. Penicillamine 14-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 409034-5 1977 However, both DP- and NAC-treated cells showed a similar sensitivity to lysis by acid serum and about the same degree of acetylcholinesterase (AChE) activity decrease, thus indicating that the susceptibility to autoxidation of lipids is not involved in the determination of complement sensitivity or in the AChE activity decrease of the sulfydryl-treated cells. Penicillamine 14-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 307-311 604161-0 1977 Spin-labeled TMA analogs as probes to study the anionic site of acetylcholinesterase. 4,4-dimethylcholesta-8,14-dien-3-ol 13-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 617949-4 1977 The AChE inactivating effect of substances such as tannic acid and glutaraldehyde, among others, might be due to a non-specific damage of the RBC membrane. Tannins 51-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 617949-4 1977 The AChE inactivating effect of substances such as tannic acid and glutaraldehyde, among others, might be due to a non-specific damage of the RBC membrane. Glutaral 67-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 16229-4 1977 AChE identification together with autoradiographic tracing of glycine showed that large cholinergic motoneurons are accompanied by small glycine-accumulating neurons with short processes which form axo-somatic and axo-dendritic contacts with large neurons. Glycine 137-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 610003-5 1977 Isolation of tissue microsomes with Tris buffer, EDTA and the protease inhibitor phenylmethylsulfonylfluoride (PMSF), conditions which preserve the receptor molecules optimally, yielded about 50% of the tissue toxin-sites, 5% of the protein, 4% of the ATPase and less than 2% of the acetylcholinesterase (AChE). Phenylmethylsulfonyl Fluoride 111-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 283-303 610003-5 1977 Isolation of tissue microsomes with Tris buffer, EDTA and the protease inhibitor phenylmethylsulfonylfluoride (PMSF), conditions which preserve the receptor molecules optimally, yielded about 50% of the tissue toxin-sites, 5% of the protein, 4% of the ATPase and less than 2% of the acetylcholinesterase (AChE). Phenylmethylsulfonyl Fluoride 111-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 305-309 1004139-0 1976 Organophosphate toxicity: kinetic differences between acetylcholinesterase of the housefly thorax and head? Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 990993-0 1976 Binding constants for tetramethylammonium ion determined with irreversible inhibitors of acetylcholinesterase. tetramethylammonium 22-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 990993-1 1976 The reversible binding constant (Ki) for tetramethylammonium ion (TMA) was determined from the decrease in the bimolecular rate constant (ki) observed with each of 21 organophosphate or carbamate inhibitors of acetylcholinesterase (EC 3.1.1.7). tetramethylammonium 41-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-230 990993-1 1976 The reversible binding constant (Ki) for tetramethylammonium ion (TMA) was determined from the decrease in the bimolecular rate constant (ki) observed with each of 21 organophosphate or carbamate inhibitors of acetylcholinesterase (EC 3.1.1.7). Organophosphates 167-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-230 990993-1 1976 The reversible binding constant (Ki) for tetramethylammonium ion (TMA) was determined from the decrease in the bimolecular rate constant (ki) observed with each of 21 organophosphate or carbamate inhibitors of acetylcholinesterase (EC 3.1.1.7). Carbamates 186-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-230 976738-6 1976 With the bis-(thioacetoxy) aurate (I) method, EM examination showed AChE-staining at NMJs of the SFM to be confined to the postjunctional membrane. bis(thioacetoxy)aurate 9-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 958212-0 1976 Free energy relationships in the inhibition of acetylcholinesterase by diethyl phosphates. diethyl phosphate 71-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 6257896-24 1980 These data suggest that quinacrine"s main action is a slow, voltage dependent blockade of open end-plate channels, though there are probably additional effects on acetylcholinesterase and channel opening. Quinacrine 24-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-183 706252-1 1978 A modified method is described for isolation of acetylcholinesterase from human erythrocytes using an additional step of gel filtration on Sephadex G-75. sephadex 139-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 699904-2 1978 Human erythrocyte acetylcholinesterase was incorporated into liposomes of different phospholipid composition by detergent depletion methods. Phospholipids 84-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 689082-0 1978 Histochemical effects of kainic acid on neostriatal dopamine and acetylcholinesterase. Kainic Acid 25-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 78970-0 1978 Studies on axoplasmic transport of individual proteins: 1--Acetylcholinesterase (AChE) in acrylamide neuropathy. Acrylamide 90-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-79 78970-0 1978 Studies on axoplasmic transport of individual proteins: 1--Acetylcholinesterase (AChE) in acrylamide neuropathy. Acrylamide 90-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 668703-2 1978 Quantitative separation of eight multiple molecular forms of acetylcholinesterase isolated from human erythrocyte membranes was accomplished by sucrose density gradient centrifugation in a zonal rotor. Sucrose 144-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 686846-6 1978 The reduction of AChE seems attributable to TCP, and not to n-hexane, whose anti-AChE activity has never been demonstrated. Tritolyl Phosphates 44-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 693562-2 1978 One possible mechanism by which delta9-THC could have its effect is by affecting acetylcholinesterase (AChE) and there is evidence that has suggested that this may be an important mechanism. Dronabinol 32-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 693562-2 1978 One possible mechanism by which delta9-THC could have its effect is by affecting acetylcholinesterase (AChE) and there is evidence that has suggested that this may be an important mechanism. Dronabinol 32-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 658423-0 1978 Reconstitution of acetylcholinesterase activity from electroplax membrane fragments into phosphatidylcholine vesicles. Phosphatidylcholines 89-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 98962-1 1978 The cutaneous nodules obtained from seven patients with von Recklinghausen"s neurofibromatosis were investigated by electron microscopy, and ultrastructural localization of acetylcholinesterase activity was demonstrated in the nerve fibers of this tumor for the first time using Karnovsky"s thiocholine method. Thiocholine 291-302 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-193 566114-0 1978 Fluorescent phosphonate label for serine hydrolases, pyrenebutyl methylphosphonofluoridate: reaction with acetylcholinesterase. Organophosphonates 12-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 566114-0 1978 Fluorescent phosphonate label for serine hydrolases, pyrenebutyl methylphosphonofluoridate: reaction with acetylcholinesterase. 4-(1-pyrenyl)butyl methylphosphonofluoridate 53-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 647007-2 1978 Glycocholate removed approximately 25% of the membrane acetylcholinesterase and 10% of the membrane phospholipid from intact human erythrocytes prior to the onset of cell lysis. Glycocholic Acid 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 661822-1 1978 Modification of the lipid phase structure of the erythrocyte membrane by phospholipases A2, C and D as well as the partial depletion of cholesterol was shown to be accompanied by the change of the acetylcholinesterase (AChE) UV-sensitivity. Cholesterol 136-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-217 661822-1 1978 Modification of the lipid phase structure of the erythrocyte membrane by phospholipases A2, C and D as well as the partial depletion of cholesterol was shown to be accompanied by the change of the acetylcholinesterase (AChE) UV-sensitivity. Cholesterol 136-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 219-223 661822-2 1978 The ability of UV-light to change the catalytic properties (Km) of the membrane-bound AChE not observed for free AChE (constant value of Km) and known as the phenomenon of photochemical allotopy, is retained in the cholesterol depleted membranes and disappears after an enzymatic treatment of the membranes by phospholipases. Cholesterol 215-226 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 204352-2 1978 In order to elucidate some features of the mechanism of the acceleration of methanesulfonylation of acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) with cationic accelerators, the methanesulfonylation of this enzyme by high concentrations of methanesulfonylfluoride, in the absence and presence of accelerators decamethonium and tetraethylammonium, was studied. methanesulfonyl fluoride 253-276 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 204352-2 1978 In order to elucidate some features of the mechanism of the acceleration of methanesulfonylation of acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) with cationic accelerators, the methanesulfonylation of this enzyme by high concentrations of methanesulfonylfluoride, in the absence and presence of accelerators decamethonium and tetraethylammonium, was studied. decamethonium 322-335 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 204352-2 1978 In order to elucidate some features of the mechanism of the acceleration of methanesulfonylation of acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) with cationic accelerators, the methanesulfonylation of this enzyme by high concentrations of methanesulfonylfluoride, in the absence and presence of accelerators decamethonium and tetraethylammonium, was studied. Tetraethylammonium 340-358 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 204352-4 1978 The results showed that the accelerator accelerates the reaction by electrostatically improving the binding between acetylcholinesterase and methanesulfonylfluoride without effecting the rate of the decomposition of the enzyme-inhibitor complex into the methanesulfonylated enzyme and product. methanesulfonyl fluoride 141-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 656488-0 1978 [Isolation of sarcolemma acetylcholinesterase fractions by gel-filtration through Sepharose 2B]. sepharose 2b 82-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 656488-1 1978 Gel-filtration of 0,6 M NaCl and 0,6 M NaCl--0,1% Triton X-100 extracts of freshly isolated sarcolemma through Sepharose 2B (1,5 X 72 cm) has revealed one symmetric peak of acetylcholinesterase activity containing phospholipid and cholesterol, moving faster than fibrinogen and tyreoglobulin. Sodium Chloride 39-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-193 656488-1 1978 Gel-filtration of 0,6 M NaCl and 0,6 M NaCl--0,1% Triton X-100 extracts of freshly isolated sarcolemma through Sepharose 2B (1,5 X 72 cm) has revealed one symmetric peak of acetylcholinesterase activity containing phospholipid and cholesterol, moving faster than fibrinogen and tyreoglobulin. Octoxynol 50-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-193 656488-1 1978 Gel-filtration of 0,6 M NaCl and 0,6 M NaCl--0,1% Triton X-100 extracts of freshly isolated sarcolemma through Sepharose 2B (1,5 X 72 cm) has revealed one symmetric peak of acetylcholinesterase activity containing phospholipid and cholesterol, moving faster than fibrinogen and tyreoglobulin. Phospholipids 214-226 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-193 656488-1 1978 Gel-filtration of 0,6 M NaCl and 0,6 M NaCl--0,1% Triton X-100 extracts of freshly isolated sarcolemma through Sepharose 2B (1,5 X 72 cm) has revealed one symmetric peak of acetylcholinesterase activity containing phospholipid and cholesterol, moving faster than fibrinogen and tyreoglobulin. Cholesterol 231-242 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-193 647082-6 1978 The different dependence of the ester substrate and appropriate alcohol binding effectiveness upon the reagent structure indicates the dissimilar location of the molecules in the active center of acetylcholinesterase. Esters 32-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 196-216 647082-6 1978 The different dependence of the ester substrate and appropriate alcohol binding effectiveness upon the reagent structure indicates the dissimilar location of the molecules in the active center of acetylcholinesterase. Alcohols 64-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 196-216 674296-0 1978 Protective effects of a series of new pyridinium derivatives against inhibition of acetylcholinesterase by fluostigmine. pyridine 38-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 674296-0 1978 Protective effects of a series of new pyridinium derivatives against inhibition of acetylcholinesterase by fluostigmine. Isoflurophate 107-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 674296-1 1978 The protective effects of a series of new pyridinium derivatives against inhibition of acetylcholinesterase (AChE) by fluostigmine was studied in vitro on human erythrocytes. pyridine 42-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 674296-1 1978 The protective effects of a series of new pyridinium derivatives against inhibition of acetylcholinesterase (AChE) by fluostigmine was studied in vitro on human erythrocytes. pyridine 42-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 674296-1 1978 The protective effects of a series of new pyridinium derivatives against inhibition of acetylcholinesterase (AChE) by fluostigmine was studied in vitro on human erythrocytes. Isoflurophate 118-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 674296-1 1978 The protective effects of a series of new pyridinium derivatives against inhibition of acetylcholinesterase (AChE) by fluostigmine was studied in vitro on human erythrocytes. Isoflurophate 118-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 674296-2 1978 It was stated that some of these compounds exhibit protective action for AChE against inhibition by fluostigmine. Isoflurophate 100-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 580191-2 1978 The inhibition of acetylcholinesterase by low concentration of epinephrine or norepinephrine was found to follow first-order reaction kinetics. Epinephrine 63-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 580191-2 1978 The inhibition of acetylcholinesterase by low concentration of epinephrine or norepinephrine was found to follow first-order reaction kinetics. Norepinephrine 78-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 580191-4 1978 The inhibition of acetylcholinesterase by epinephrine was found to be of the mixed type while its inhibition by norepinephrine was of the competitive type. Epinephrine 42-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 736984-0 1978 Reactivation and aging of cyclopentyl methylphosphonylated acetylcholinesterase in the presence of some 1-alkyl-2-hydroxyiminomethyl-pyridinium salts. 1-alkyl-2-hydroxyiminomethyl-pyridinium salts 104-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 693539-0 1978 Histochemical effects of kainic acid on neostriatal dopamine and acetylcholinesterase. Kainic Acid 25-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 592327-2 1977 A number of bis- and mono-N-substituted benzoquinolinium salts and their analogues were prepared and evaluated as inhibitors of acetylcholinesterase (AcChE) and butyrylcholinesterase (BuChE). bis- and mono-n-substituted benzoquinolinium salts 12-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 592327-2 1977 A number of bis- and mono-N-substituted benzoquinolinium salts and their analogues were prepared and evaluated as inhibitors of acetylcholinesterase (AcChE) and butyrylcholinesterase (BuChE). bis- and mono-n-substituted benzoquinolinium salts 12-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-155 592327-8 1977 A bis-quaternary ammonium compound with a flexible bridge that links the two nitrogen atoms was found to be more potent in inhibiting AcChE and less potent in inhibiting BuChE than a bis-quaternary ammonium compound with a rigid bridge. bis-quaternary ammonium 2-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-139 592327-8 1977 A bis-quaternary ammonium compound with a flexible bridge that links the two nitrogen atoms was found to be more potent in inhibiting AcChE and less potent in inhibiting BuChE than a bis-quaternary ammonium compound with a rigid bridge. Nitrogen 77-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-139 592327-8 1977 A bis-quaternary ammonium compound with a flexible bridge that links the two nitrogen atoms was found to be more potent in inhibiting AcChE and less potent in inhibiting BuChE than a bis-quaternary ammonium compound with a rigid bridge. bis-quaternary ammonium 183-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-139 592327-9 1977 The acridinium and phenanthridinium derivatives of the benzoquinolinium compounds are very potent reversible inhibitors against both AcChE and BuChE. acridinium I 4-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-138 592327-9 1977 The acridinium and phenanthridinium derivatives of the benzoquinolinium compounds are very potent reversible inhibitors against both AcChE and BuChE. phenanthridinium 19-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-138 592327-9 1977 The acridinium and phenanthridinium derivatives of the benzoquinolinium compounds are very potent reversible inhibitors against both AcChE and BuChE. benzoquinolinium 55-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-138 595793-2 1977 Eserine sulphate (10(-5) M) was used as inhibitor for AChE. Eserine sulfate 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 20963-1 1977 Phenylacetone, 4-phenyl-2-butanone, and 4-oxopentyltrimethylammonium chloride were tested as potential transition state analogs for eel acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7). 1-phenyl-2-propanone 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 20963-1 1977 Phenylacetone, 4-phenyl-2-butanone, and 4-oxopentyltrimethylammonium chloride were tested as potential transition state analogs for eel acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7). BENZYLACETONE 15-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 20963-1 1977 Phenylacetone, 4-phenyl-2-butanone, and 4-oxopentyltrimethylammonium chloride were tested as potential transition state analogs for eel acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7). 4-oxopentyltrimethylammonium chloride 40-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 913568-0 1977 Non-lytic release of acetylcholinesterase from erythrocytes by a phosphatidylinositol-specific phospholipase C. Phosphatidylinositols 65-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 562134-0 1977 Identification of discrete disulfide-linked oligomers which distinguish 18 S from 14 S acetylcholinesterase. Disulfides 27-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 578475-0 1977 [On the effect of iodine containing opaque media on erythrocyte acetylcholinesterase (author"s transl)]. Iodine 18-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 578475-2 1977 The inhibition of acetylcholinesterase of human erythrocytes was tested with the following opaque media in vivo and in vitro: adipiodonmeglumine, meglumine-iothalamate and sodium-iothalamate. adipiodonmeglumine 126-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 578475-2 1977 The inhibition of acetylcholinesterase of human erythrocytes was tested with the following opaque media in vivo and in vitro: adipiodonmeglumine, meglumine-iothalamate and sodium-iothalamate. Iothalamate Meglumine 146-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 578475-2 1977 The inhibition of acetylcholinesterase of human erythrocytes was tested with the following opaque media in vivo and in vitro: adipiodonmeglumine, meglumine-iothalamate and sodium-iothalamate. Iothalamic Acid 172-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 578475-4 1977 For patients with congenital variants of acetylcholinesterase it could be of clinical consequence under succinyldicholinanaesthesia. succinyldicholinanaesthesia 104-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 19036-0 1977 Effects of quaternary ligands on the inhibition of acetylcholinesterase by arsenite. arsenite 75-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 19036-1 1977 Arsenite inhibits acetylcholinesterase in a second-order reaction. arsenite 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 19036-5 1977 Although the kinetic data are consistent with a covalent reaction between arsenite and acetylcholinesterase, chemical evidence excludes the involvement of sulfhydryl groups which are usually implicated in arsenite inhibition. arsenite 74-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 16611-0 1977 Effect of imidazoles and pH on aging of phosphylated acetylcholinesterase. Imidazoles 10-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 402443-4 1977 In the other 3 animals, which received 0.20 mg/kg DFP 10, 12 and 18 hr prior to sacrifice, AChE activity is greatly reduced in the neuropil of those structures which normally show intense AChE activity in pharmacologically unmanipulated monkeys. Isoflurophate 50-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 402443-4 1977 In the other 3 animals, which received 0.20 mg/kg DFP 10, 12 and 18 hr prior to sacrifice, AChE activity is greatly reduced in the neuropil of those structures which normally show intense AChE activity in pharmacologically unmanipulated monkeys. Isoflurophate 50-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-192 564313-0 1977 Inhibition of acetylcholinesterase from different species by organophosphorus compounds, carbamates and methylsulphonyfluoride. organophosphorus 61-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 564313-0 1977 Inhibition of acetylcholinesterase from different species by organophosphorus compounds, carbamates and methylsulphonyfluoride. Carbamates 89-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 564313-0 1977 Inhibition of acetylcholinesterase from different species by organophosphorus compounds, carbamates and methylsulphonyfluoride. methylsulphonyfluoride 104-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 143176-4 1977 Comparing literary data concerning the nonmediator role of acetyl-choline and catecholeamines with personal studies, the authors demonstrate the internal and external barrier functions of acetylcholinesterase and monoamineoxidase in the brain. Acetylcholine 59-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-208 143176-4 1977 Comparing literary data concerning the nonmediator role of acetyl-choline and catecholeamines with personal studies, the authors demonstrate the internal and external barrier functions of acetylcholinesterase and monoamineoxidase in the brain. catecholeamines 78-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-208 1029908-1 1976 Water, saline and ethanol extracts of Eugenia caryophyllus inhibited brain acetylcholinesterase (AchE) activity. Water 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 1029908-1 1976 Water, saline and ethanol extracts of Eugenia caryophyllus inhibited brain acetylcholinesterase (AchE) activity. Water 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 1029908-1 1976 Water, saline and ethanol extracts of Eugenia caryophyllus inhibited brain acetylcholinesterase (AchE) activity. Sodium Chloride 7-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 1029908-1 1976 Water, saline and ethanol extracts of Eugenia caryophyllus inhibited brain acetylcholinesterase (AchE) activity. Sodium Chloride 7-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 1029908-1 1976 Water, saline and ethanol extracts of Eugenia caryophyllus inhibited brain acetylcholinesterase (AchE) activity. Ethanol 18-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 1029908-1 1976 Water, saline and ethanol extracts of Eugenia caryophyllus inhibited brain acetylcholinesterase (AchE) activity. Ethanol 18-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 1008237-2 1976 Acetylcholinesterase is structurally bound at the cholinergic synaptic junction being of physiological significance for hydrolyzing the transmitter substance acetylcholine. Acetylcholine 158-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 986552-0 1976 Comparison of the effect of the reversible inhibitor hexamethylenebis-[dimethyl-(3-phthalimidopropyl) ammonium bromide] upon the hydrolysis of several substrates by acetylcholinesterase. hexamethylenebis(dimethyl-(3-phthalimidopropyl)ammonium bromide) 53-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-185 136679-0 1976 [Serum acetylcholinesterase changes after pancuronium administration]. Pancuronium 42-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 7-27 136679-3 1976 The enzyme concentrations were lower in those patients that had also received Pancuronium, suggesting a cummulative inhibitory effect on serum acetylcholinesterase. Pancuronium 78-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 949333-0 1976 Inhibition of acetylcholinesterase by derivatives of 1,3,2-dioxaphosphorinane 2-oxide. 1,3,2-dioxaphosphorinane-2-oxide 53-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 1270513-3 1976 Treatment of whole cells with 5 mM diazotized sulfanilic acid revealed that most of the AChE is located on the external surface of the cell membrane. diazotized 35-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 1270513-3 1976 Treatment of whole cells with 5 mM diazotized sulfanilic acid revealed that most of the AChE is located on the external surface of the cell membrane. Sulfanilic Acids 46-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 940960-0 1976 Inhibition of human erythrocyte acetylcholinesterase by succinyldicholine. Succinylcholine 56-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 940960-1 1976 When human erythrocyte acetylcholinesterase (AChE) is inhibited by succinyldicholine (SuCh) at low ionic strength, mu = 0.03, two apparent affinity constants for the inhibitor can be distinguished, KI(1) = 5.4 X 10-5 M and KI(2) = 1.3 X 10-5 M. Increasing the ionic strength to mu = 0.58 increases KI(1) to 1.1 X 10-4 M, but abolishes the contribution of KI(2) completely. Succinylcholine 67-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 940960-1 1976 When human erythrocyte acetylcholinesterase (AChE) is inhibited by succinyldicholine (SuCh) at low ionic strength, mu = 0.03, two apparent affinity constants for the inhibitor can be distinguished, KI(1) = 5.4 X 10-5 M and KI(2) = 1.3 X 10-5 M. Increasing the ionic strength to mu = 0.58 increases KI(1) to 1.1 X 10-4 M, but abolishes the contribution of KI(2) completely. Succinylcholine 67-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 934442-0 1976 Changes of acetylcholinesterase activity in three major brain areas and related changes in behaviour following acute treatment with diisopropyl fluorophosphate. Isoflurophate 132-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 1025896-1 1976 Appearance of low molecular components of acetylcholinesterase from erythrocyte membranes was found by gel filtration on Sephadex G-200 and polyacrylamide gel disc electrophoresis. sephadex 121-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 1025896-1 1976 Appearance of low molecular components of acetylcholinesterase from erythrocyte membranes was found by gel filtration on Sephadex G-200 and polyacrylamide gel disc electrophoresis. polyacrylamide 140-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 1261560-1 1976 Human erythrocyte acetylcholinesterase preparations which vary in lipid content, from lipid-rich to lipid-poor, have been successfully prepared using deoxycholate. Deoxycholic Acid 150-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 1261560-7 1976 Based on the data presented, it was concluded that acetylcholinesterase is a phospholipoprotein, and its activity is highly dependent on its phospholipid component. Phospholipids 141-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 1247562-2 1976 Acetylcholinesterase activity of human erythrocytes is known to be inhibited by linolenoyl sorbitol, the inhibition being critically dependent on cell membrane intactness. linolenoyl sorbitol 80-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 970243-1 1976 The localization of acetylcholinesterase (AChE) activity in the nuclei of the amygdaloid body of man was studied by Gerebtzoff"s modification of Koelle"s acetylthiocholine method on 10 human brains. Acetylthiocholine 154-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 970243-1 1976 The localization of acetylcholinesterase (AChE) activity in the nuclei of the amygdaloid body of man was studied by Gerebtzoff"s modification of Koelle"s acetylthiocholine method on 10 human brains. Acetylthiocholine 154-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 937144-1 1976 From cell fractionation studies it is concluded that gangliosides have a wide distribution in neuronal plasma membranes, being concentrated in the microsomal and the nerve-ending membranes rich in acetylcholinesterase. Gangliosides 53-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-217 1015993-0 1976 Potential acetylcholinesterase reactivators: oxime and amidoxime derivatives. Oximes 45-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-30 1015993-0 1976 Potential acetylcholinesterase reactivators: oxime and amidoxime derivatives. amidoxime 55-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-30 1036947-0 1976 [Reactivation of phosphorylated acetylcholinesterase (AChE): quaternary salts of vinylogous pyridinaldoxims (author"s transl)]. pyridinaldoxims 92-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 1036947-0 1976 [Reactivation of phosphorylated acetylcholinesterase (AChE): quaternary salts of vinylogous pyridinaldoxims (author"s transl)]. pyridinaldoxims 92-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 1036947-3 1976 In this case the formal insertion of an ethylenic double bond between the pyridinium ring and the aldoxime group decreases the ability to reactivate phosphorylated acetylcholinesterase (AChE). pyridine 74-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-184 1036947-3 1976 In this case the formal insertion of an ethylenic double bond between the pyridinium ring and the aldoxime group decreases the ability to reactivate phosphorylated acetylcholinesterase (AChE). pyridine 74-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 1037275-2 1976 This prompted us to determine the amount of inhibition of human acetylcholinesterase by the following contrast media in vivo and in vitro: methyl glucamineiodipamide (Biligrafin forte), methylglucamine iothalamate (Conray 60), sodium-iothalamate (Conray 80). meglumine iodipamide 139-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 1037275-2 1976 This prompted us to determine the amount of inhibition of human acetylcholinesterase by the following contrast media in vivo and in vitro: methyl glucamineiodipamide (Biligrafin forte), methylglucamine iothalamate (Conray 60), sodium-iothalamate (Conray 80). Meglumine iodipamide 167-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 1037275-2 1976 This prompted us to determine the amount of inhibition of human acetylcholinesterase by the following contrast media in vivo and in vitro: methyl glucamineiodipamide (Biligrafin forte), methylglucamine iothalamate (Conray 60), sodium-iothalamate (Conray 80). Iothalamate Meglumine 215-221 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 1037275-2 1976 This prompted us to determine the amount of inhibition of human acetylcholinesterase by the following contrast media in vivo and in vitro: methyl glucamineiodipamide (Biligrafin forte), methylglucamine iothalamate (Conray 60), sodium-iothalamate (Conray 80). Iothalamic Acid 227-245 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 1037275-2 1976 This prompted us to determine the amount of inhibition of human acetylcholinesterase by the following contrast media in vivo and in vitro: methyl glucamineiodipamide (Biligrafin forte), methylglucamine iothalamate (Conray 60), sodium-iothalamate (Conray 80). Iothalamate Meglumine 247-253 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 939223-2 1976 Acetylcholinesterase (EAChE; acetylcholine acetyl hydrolase, EC 3.1.1.7) was prepared from the erythrocyte membrane of Chinese adult males, and solubilised with 1% Triton X-100 in 20 mmol/l phosphate buffer, pH 7.4. Octoxynol 164-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 939223-2 1976 Acetylcholinesterase (EAChE; acetylcholine acetyl hydrolase, EC 3.1.1.7) was prepared from the erythrocyte membrane of Chinese adult males, and solubilised with 1% Triton X-100 in 20 mmol/l phosphate buffer, pH 7.4. Phosphates 190-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 1072540-0 1976 Bis-2,5-(4-hydroxyiminomethylpyridinium)-2,5-dihydrofurane dibromide as reactivator of phosphonylated acetylcholinesterase. bis-2,5-(4-hydroxyiminomethylpyridinium)-2,5-dihydrofurane dibromide 0-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 177158-8 1975 It is concluded that acetylcholinesterase (EC 3.1.1.7) of red cells rapidly hydrolyzes acetylcholine mustard aziridinium ion to acetate and choline mustard aziridinium and the latter compound can act as a potent inhibitor of choline transport. Acetates 128-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 177158-8 1975 It is concluded that acetylcholinesterase (EC 3.1.1.7) of red cells rapidly hydrolyzes acetylcholine mustard aziridinium ion to acetate and choline mustard aziridinium and the latter compound can act as a potent inhibitor of choline transport. aziridinium 156-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 177158-8 1975 It is concluded that acetylcholinesterase (EC 3.1.1.7) of red cells rapidly hydrolyzes acetylcholine mustard aziridinium ion to acetate and choline mustard aziridinium and the latter compound can act as a potent inhibitor of choline transport. Choline 93-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 1206408-0 1975 Inhibition of acetylcholinesterase by bicuculline and related alkaloids. Bicuculline 38-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 1206408-0 1975 Inhibition of acetylcholinesterase by bicuculline and related alkaloids. Alkaloids 62-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 172135-0 1975 Differential effects of denaturing agents on acetylcholinesterase: insensitivity of the reaction of methanesulfonyl fluoride compared to diisopropylphosphorofluoridate and p-nitrophenyl acetate. 4-nitrophenyl acetate 172-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 1236951-1 1975 The dissociation constants have been determined and compared for a series of reversible, noncovalent inhibitors of eel acetylcholinesterase that are structurally related to the very potent inhibitor, 1,2,3,4-tetrahydro-9-aminoacridine (THA). Tacrine 200-234 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 1236951-1 1975 The dissociation constants have been determined and compared for a series of reversible, noncovalent inhibitors of eel acetylcholinesterase that are structurally related to the very potent inhibitor, 1,2,3,4-tetrahydro-9-aminoacridine (THA). Tacrine 236-239 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 241402-1 1975 Acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) is readily in hibited by 10(-5) M diphenylphosphorochloridate even though the inhibitor hydrolyzes in a few seconds. diphenylphosphorylchloridate 93-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 1190369-6 1975 Hycanthone is an inhibitor of acetylcholinesterase (ACHE) from S. mansoni, but is less effective against ACHE of mammalian origin. Hycanthone 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 1190369-6 1975 Hycanthone is an inhibitor of acetylcholinesterase (ACHE) from S. mansoni, but is less effective against ACHE of mammalian origin. Hycanthone 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 1174747-0 1975 Toxicity, acetylcholinesterase inhibition and metabolism of enolic phosphate esters resembling the insecticide, phosdrin. Mevinphos 112-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-30 1191483-5 1975 Pancuronium inhibition of the acetylcholinesterase in human red blood cells and from the electric eel was more than one thousand times weaker. Pancuronium 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 3076-4 1975 The localization of AChE, BuChE products of cytochemical reaction on sodium suggests that the cholinergic mechanism may take part in the process of synaptic transmission. Sodium 69-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 1171220-0 1975 Interactions of acetylcholine mustard with acetylcholinesterase. Acetylcholine 16-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 1171220-1 1975 The hydrolysis of acetylcholine and acetylcholine mustard by acetylcholinesterase was compared over a substrate concentration range of 1-10 mM. Acetylcholine 18-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 1171220-1 1975 The hydrolysis of acetylcholine and acetylcholine mustard by acetylcholinesterase was compared over a substrate concentration range of 1-10 mM. Acetylcholine 36-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 1148400-2 1975 Normal red cells and ACHE-deficient red cells are separated in accordance with their density and then exposed to trypsin, cephalothin and tannic acid. Cephalothin 122-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 1148400-2 1975 Normal red cells and ACHE-deficient red cells are separated in accordance with their density and then exposed to trypsin, cephalothin and tannic acid. Tannins 138-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 1191262-0 1975 The effect of some amine oxides and disulphide compounds on the activity of acetylcholinesterase. amine oxides 19-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 1191262-0 1975 The effect of some amine oxides and disulphide compounds on the activity of acetylcholinesterase. disulphide 36-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 1191262-1 1975 Three amine oxides, two aliphatic and one aromatic, and 2,2"-dithiodipyridine were found to be weak reversible inhibitors of acetylcholinesterase. amine oxides 6-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 1191262-1 1975 Three amine oxides, two aliphatic and one aromatic, and 2,2"-dithiodipyridine were found to be weak reversible inhibitors of acetylcholinesterase. aliphatic 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 1191262-1 1975 Three amine oxides, two aliphatic and one aromatic, and 2,2"-dithiodipyridine were found to be weak reversible inhibitors of acetylcholinesterase. 2,2'-dipyridyl disulfide 56-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 1157827-0 1975 Sulfur mustards induce neurite extension and acetylcholinesterase synthesis in cultured neuroblastoma cells. Mustard Gas 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 1181266-1 1975 The acetylcholinesterase from human erythrocytes was released from the plasma membrane with 0.2% Triton X-100 at low ionic strength and purified by two affinity chromatography steps on Sepharose-bound m-[6-(6-amino-caproylamino)caproylamino]phenyltrimethyl-ammonium. Octoxynol 97-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 1181266-1 1975 The acetylcholinesterase from human erythrocytes was released from the plasma membrane with 0.2% Triton X-100 at low ionic strength and purified by two affinity chromatography steps on Sepharose-bound m-[6-(6-amino-caproylamino)caproylamino]phenyltrimethyl-ammonium. Sepharose 185-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 1181266-1 1975 The acetylcholinesterase from human erythrocytes was released from the plasma membrane with 0.2% Triton X-100 at low ionic strength and purified by two affinity chromatography steps on Sepharose-bound m-[6-(6-amino-caproylamino)caproylamino]phenyltrimethyl-ammonium. -[6-(6-amino-caproylamino)caproylamino]phenyltrimethyl-ammonium 202-265 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 1125207-2 1975 A bis-quaternary fluorescence probe, propidium diiodide, has been found to exhibit a tenfold enhancement of fluorescence when bound to acetylcholinesterase from Torpedo california. Propidium 37-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 1125207-13 1975 Although propidium and edrophonium associate at separate sites on acetylcholinesterase, bis-quaternary ligands where the quaternary nitrogens are separated by 14 A displace both ligands from the enzyme with equal effectiveness. Propidium 9-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 1125207-13 1975 Although propidium and edrophonium associate at separate sites on acetylcholinesterase, bis-quaternary ligands where the quaternary nitrogens are separated by 14 A displace both ligands from the enzyme with equal effectiveness. Edrophonium 23-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 235931-0 1975 Mechanism of inhibition in vitro of mammalian acetylcholinesterase and cholinesterase in solutions of 0,0-dimethyl 2,2,2-trichloro-1-hydroxyethyl phosphonate (Trichlorphon). 0,0-dimethyl 2,2,2-trichloro-1-hydroxyethyl phosphonate 102-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 235931-0 1975 Mechanism of inhibition in vitro of mammalian acetylcholinesterase and cholinesterase in solutions of 0,0-dimethyl 2,2,2-trichloro-1-hydroxyethyl phosphonate (Trichlorphon). Trichlorfon 159-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 1151640-1 1975 NMR was used to study the binding of acetylcholine, atropine, and physostigmine to acetylcholinesterase. Acetylcholine 37-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 1151640-1 1975 NMR was used to study the binding of acetylcholine, atropine, and physostigmine to acetylcholinesterase. Atropine 52-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 1151640-1 1975 NMR was used to study the binding of acetylcholine, atropine, and physostigmine to acetylcholinesterase. Physostigmine 66-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 1151640-4 1975 The dissociation constant, KD and the linewidth of the acetylcholinesterase-inhibitor complex, increment v bound, for atropine and physostigmine can be estimated from the linewidth changes of the N-methyl and phenyl group resonances of atropine and from the N-methyl and C-methyl group resonances of physostigmine resulting from association with the enzyme. Atropine 118-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 1151640-4 1975 The dissociation constant, KD and the linewidth of the acetylcholinesterase-inhibitor complex, increment v bound, for atropine and physostigmine can be estimated from the linewidth changes of the N-methyl and phenyl group resonances of atropine and from the N-methyl and C-methyl group resonances of physostigmine resulting from association with the enzyme. Physostigmine 131-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 1151640-4 1975 The dissociation constant, KD and the linewidth of the acetylcholinesterase-inhibitor complex, increment v bound, for atropine and physostigmine can be estimated from the linewidth changes of the N-methyl and phenyl group resonances of atropine and from the N-methyl and C-methyl group resonances of physostigmine resulting from association with the enzyme. Atropine 236-244 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 1151640-4 1975 The dissociation constant, KD and the linewidth of the acetylcholinesterase-inhibitor complex, increment v bound, for atropine and physostigmine can be estimated from the linewidth changes of the N-methyl and phenyl group resonances of atropine and from the N-methyl and C-methyl group resonances of physostigmine resulting from association with the enzyme. Physostigmine 300-313 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 235987-1 1975 Acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) and cholinesterase (acylcholine acylhydrolase, EC 3.1.1.8), respectively, were covalently attached to a cross-linked copolymerisate of maleinic anhydride and butanediol-divinylether. copolymerisate 176-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 235987-1 1975 Acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) and cholinesterase (acylcholine acylhydrolase, EC 3.1.1.8), respectively, were covalently attached to a cross-linked copolymerisate of maleinic anhydride and butanediol-divinylether. maleinic anhydride 194-212 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 235987-1 1975 Acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) and cholinesterase (acylcholine acylhydrolase, EC 3.1.1.8), respectively, were covalently attached to a cross-linked copolymerisate of maleinic anhydride and butanediol-divinylether. butanediol divinylether 217-240 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 1167578-0 1975 The effect of aliphatic alcohols on the hydrolysis of acetylcholine by acetylcholinesterase. Propylene Glycol 14-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 1167578-0 1975 The effect of aliphatic alcohols on the hydrolysis of acetylcholine by acetylcholinesterase. Acetylcholine 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 1112187-0 1975 [Effect of charge-free organophosphorus inhibitors on intensifying the substrate inhibition of acetylcholinesterase]. organophosphorus 23-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-116 1063663-0 1975 The importance of the decreased susceptibility of acetylcholinesterase in the resistance of houseflies to organophosphorus insecticides. organophosphorus 106-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 1126334-0 1975 Stability of membrane acetylcholinesterase in human erythrocytes treated with tetraphenylboron. Tetraphenylborate 78-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 1030881-5 1976 Suberyldicholine was shown to be highly active reversible inhibitor of competitive--non-competitive type (Ki=2.3-10(-6)M, alpha=0.5) of acetylcholinesterase from human erythrocytes; the inhibitory effect of monocholic ester of suberic acid was distinctly lower. subecholine 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 1030881-5 1976 Suberyldicholine was shown to be highly active reversible inhibitor of competitive--non-competitive type (Ki=2.3-10(-6)M, alpha=0.5) of acetylcholinesterase from human erythrocytes; the inhibitory effect of monocholic ester of suberic acid was distinctly lower. suberic acid 227-239 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 1030881-7 1976 The reversible binding and the enzymatic hydrolysis of suberyldicholine by acetylcholinesterase of tissues were likely to be the main factors that determined the effectiveness and prolonged blocking action of suberyldicholine on the nerve-muscle conductivity. subecholine 55-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 1030881-7 1976 The reversible binding and the enzymatic hydrolysis of suberyldicholine by acetylcholinesterase of tissues were likely to be the main factors that determined the effectiveness and prolonged blocking action of suberyldicholine on the nerve-muscle conductivity. subecholine 209-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 1109571-5 1975 It is shown that the affinity of various inhibitors (32) and acetylcholinesterase is a function of CT and pi (Hansch hydrophobicity constant). Carbon Tetrachloride 99-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 1185160-0 1975 Acetylcholinesterase neurons in dopamine-containing regions of the brain. Dopamine 32-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 1185160-3 1975 With the present technique, based on the differential regeneration of AChE in the separate subcellular compartments of the neuron (i.e., axon, dendrite, soma) after intramuscular injection of bis-(1-methylethyl)-phosphorofluoridate (di-isopropylfluorophosphate: DFP), it was shown that AChE was associated with neurons whose cell bodies lay within the brain areas studied. Isoflurophate 192-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 1185160-3 1975 With the present technique, based on the differential regeneration of AChE in the separate subcellular compartments of the neuron (i.e., axon, dendrite, soma) after intramuscular injection of bis-(1-methylethyl)-phosphorofluoridate (di-isopropylfluorophosphate: DFP), it was shown that AChE was associated with neurons whose cell bodies lay within the brain areas studied. Isoflurophate 192-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 286-290 1185160-3 1975 With the present technique, based on the differential regeneration of AChE in the separate subcellular compartments of the neuron (i.e., axon, dendrite, soma) after intramuscular injection of bis-(1-methylethyl)-phosphorofluoridate (di-isopropylfluorophosphate: DFP), it was shown that AChE was associated with neurons whose cell bodies lay within the brain areas studied. Isoflurophate 233-260 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 1185160-3 1975 With the present technique, based on the differential regeneration of AChE in the separate subcellular compartments of the neuron (i.e., axon, dendrite, soma) after intramuscular injection of bis-(1-methylethyl)-phosphorofluoridate (di-isopropylfluorophosphate: DFP), it was shown that AChE was associated with neurons whose cell bodies lay within the brain areas studied. Isoflurophate 262-265 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 1178678-0 1975 Localization of acetylcholinesterase within dopamine containing neurons in the zona compacta of the substantia nigra. Dopamine 44-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 4433524-0 1974 [A new, specific and reversible bifunctional alkylborinic acid inhibitor of acetylcholinesterase]. alkylborinic acid 45-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-97 4548065-3 1974 Return of enzymatic activity after irreversible inhibition of AChE in "differentiated" cells was blocked by cycloheximide, but not by cordycepin or actinomycin D, suggesting that protein but not mRNA synthesis was required for replacement. Cycloheximide 108-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 4429699-0 1974 Methanesulfonyl fluoride inactivation of acetylcholinesterase in the presence of substrates and reversible inhibitors. methanesulfonyl fluoride 0-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 4425686-0 1974 [Structural rearrangements in erythrocyte membranes, induced by interactions with acetylcholine, and their relation to the catalytic properties of acetylcholinesterase]. Acetylcholine 82-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-168 4848956-0 1974 [Inhibition of acetylcholinesterase caused by fluoride]. Fluorides 46-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 4826866-0 1974 Methods of the estimation of acetylcholinesterase activity in the erythrocytes of laboratory animals given carbamates or organophosphorus compounds. Carbamates 107-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 4826866-0 1974 Methods of the estimation of acetylcholinesterase activity in the erythrocytes of laboratory animals given carbamates or organophosphorus compounds. organophosphorus 121-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 4826873-0 1974 The inactivation of acetylcholinesterase by trimethyloxonium ion, an active-site-directed methylating agent. trimethyloxonium 44-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 4458970-0 1974 [Rate of aging of acetylcholinesterase and butyrylcholine esterase inhibited by O-isopropyl-S-(2-diisopropylaminoethyl)-methylthiophosphonate]. 2-isopropyl-S-(2-diisopropylaminoethyl)methylthiophosphonate 80-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 4611985-0 1974 On the chemical basis of thiocholine methods for demonstration of acetylcholinesterase activities. Thiocholine 25-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 4534273-0 1974 Dihydrofurane and tetrahydrofurane derivatives of pyridinealdoximes reactivators of isopropylmethylphosphonylated acetylcholinesterase. dihydrofurane 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 4534273-0 1974 Dihydrofurane and tetrahydrofurane derivatives of pyridinealdoximes reactivators of isopropylmethylphosphonylated acetylcholinesterase. tetrahydrofuran 18-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 4534273-0 1974 Dihydrofurane and tetrahydrofurane derivatives of pyridinealdoximes reactivators of isopropylmethylphosphonylated acetylcholinesterase. pyridinealdoximes 50-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 4586721-0 1973 [Phosphonyloxime of soman; formation and reaction with acetylcholinesterase in vitro]. phosphonyloxime 1-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 4586721-0 1973 [Phosphonyloxime of soman; formation and reaction with acetylcholinesterase in vitro]. Soman 20-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 4795368-0 1973 Concerning the rate limiting step in the hydrolysis of substituted phenyl acetates by acetylcholinesterase. Phenylacetates 67-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 4745735-0 1973 Interaction of proflavine and acriflavine with acetylcholinesterase. Proflavine 15-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 4745735-0 1973 Interaction of proflavine and acriflavine with acetylcholinesterase. Acriflavine 30-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 4737014-0 1973 Recording spectrophotometric method for determination of dissociation and phosphorylation constants for the inhibition of acetylcholinesterase by organophosphates in the presence of substrate. Organophosphates 146-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 4733238-2 1973 Acetylcholinesterase from human erythrocytes was solubilized with Triton X-100 in strong salt solution and partially purified by (NH(4))(2)SO(4) fractionation. Octoxynol 66-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 4733238-2 1973 Acetylcholinesterase from human erythrocytes was solubilized with Triton X-100 in strong salt solution and partially purified by (NH(4))(2)SO(4) fractionation. Salts 89-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 4795479-1 1973 Inhibition of acetylcholinesterase using fluorine ions]. Fluorine 41-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 4695666-0 1973 Inhibition of cholinesterase and acetylcholinesterase in vitro by butyrophenone neuroleptics. Butyrophenones 66-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 4771884-0 1973 [A study of the relationship between the rapidity of acetylcholine hydrolysis and its concentration under the influence of acetylcholinesterase and whole erythrocytes subjected to Cs-137 irradiation]. Acetylcholine 53-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-143 4735459-0 1973 Interaction of 3-quinuclidinol and its derivatives with acetylcholinesterase. 3-quinuclidinol 15-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 4788714-0 1973 [Proceedings: Separation of serum acetylcholinesterase isoenzymes on cellulose acetate]. acetylcellulose 69-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 4803241-0 1973 [Activity of acetylcholinesterase in vivo and in vitro in the presence of biquaternary ammonium compounds]. Ammonium Compounds 87-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-33 4274701-0 1973 Effect of diisopropylfluorophosphate, edrophonium and a stabilizing agent on the conformation of acetylcholinesterase. Isoflurophate 10-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 4274701-0 1973 Effect of diisopropylfluorophosphate, edrophonium and a stabilizing agent on the conformation of acetylcholinesterase. Edrophonium 38-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 4652642-0 1972 Acetylcholinesterase substrates: acetoxymethylpyridines and benzyl acetate. acetoxymethylpyridines 33-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 4652642-0 1972 Acetylcholinesterase substrates: acetoxymethylpyridines and benzyl acetate. benzyl acetate 60-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 5073767-0 1972 Activation of acetylcholinesterase by Triton X-100. Octoxynol 38-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 5083615-2 1972 A study by nuclear magnetic resonance of the acceleration of acetylcholinesterase by atropine and inhibition by eserine. Atropine 85-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 5083616-0 1972 Purification and fractionation of acetylcholinesterase into subspecies by affinity chromatography on a d-tubocurarine--sepharose column. Tubocurarine 103-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 5083616-0 1972 Purification and fractionation of acetylcholinesterase into subspecies by affinity chromatography on a d-tubocurarine--sepharose column. Sepharose 119-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 5064446-0 1972 Inhibition of acetylcholinesterase by the enantiomers of isopropyl S-2-trimethylammonioethyl methylphosphono-thioate iodide. isopropyl s-2-trimethylammonioethyl methylphosphono-thioate iodide 57-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 4672142-0 1972 [Reactions of acetylcholinesterase occupying the active center and of secondary binding sites induced by acetylcholine and methylcholine]. methylcholine 123-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 4556090-0 1972 Influence of acetyl- -methylcholine, carbamoylcholine, and bis-pyridinium compounds on the activity of acetylcholinesterase. Methacholine Chloride 13-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 4556090-0 1972 Influence of acetyl- -methylcholine, carbamoylcholine, and bis-pyridinium compounds on the activity of acetylcholinesterase. Carbachol 37-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 4556090-0 1972 Influence of acetyl- -methylcholine, carbamoylcholine, and bis-pyridinium compounds on the activity of acetylcholinesterase. bis-pyridinium 59-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 5002755-0 1971 Affinity of human brain acetylcholinesterase to some organophosphates and carbamates in vitro. Organophosphates 53-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 5002755-0 1971 Affinity of human brain acetylcholinesterase to some organophosphates and carbamates in vitro. Carbamates 74-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 5135897-0 1971 Measurement of the rate of acetylcholine diffusion through a brain slice and its significance in studies of the cellular distribution of acetylcholinesterase. Acetylcholine 27-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 4328180-1 1971 The binding of atropine and eserine to acetylcholinesterase. Atropine 15-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 5166251-0 1971 A comparative study of the interactions of the nonpolar fluorescent ligand, 1-anilino-8-naphthalene sulfonic acid, with butyryl and acetylcholinesterase. 1-anilino-8-naphthalenesulfonate 76-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-152 4951269-0 1971 Utilization of [32P] soman for measurement of acetylcholinesterase in brain tissues. Phosphorus-32 16-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 4100994-0 1971 Localization of acetylcholinesterase via production of osmiophilic polymers: new benzenediazonium salts with thiolacetate functions. Polymers 67-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 4100994-0 1971 Localization of acetylcholinesterase via production of osmiophilic polymers: new benzenediazonium salts with thiolacetate functions. benzenediazonium salts 81-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 4100994-0 1971 Localization of acetylcholinesterase via production of osmiophilic polymers: new benzenediazonium salts with thiolacetate functions. Thien-2-ylacetate 109-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 5559195-0 1971 Clinical features and plasma acetylcholinesterase activity in poisoning with insecticidal organophosphorous compounds. organophosphorous 90-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 5103905-0 1971 Methods for the estimation of acetylcholinesterase activity in the plasma and brain of laboratory animals given carbamates or organophosphorus compounds. Carbamates 112-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 5103905-0 1971 Methods for the estimation of acetylcholinesterase activity in the plasma and brain of laboratory animals given carbamates or organophosphorus compounds. organophosphorus 126-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 5566046-0 1971 In vitro effects of polyvinylpyrrolidone and sucrose on the acetylcholinesterase, succinate dehydrogenase and lactate dehydrogenase activities in the brain. Povidone 20-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 5566046-0 1971 In vitro effects of polyvinylpyrrolidone and sucrose on the acetylcholinesterase, succinate dehydrogenase and lactate dehydrogenase activities in the brain. Sucrose 45-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 4395889-0 1971 Inhibition of acetylcholinesterase by dibenamine and dibenzyline. Dibenzylchlorethamine 38-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 4395889-0 1971 Inhibition of acetylcholinesterase by dibenamine and dibenzyline. Phenoxybenzamine 53-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 5291386-0 1971 The reaction of acetylcholinesterase with N,N"-polymethylene-bis-(4-pyridinealdoxime) dibromides. n,n"-polymethylene-bis-(4-pyridinealdoxime) dibromides 42-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 5460001-0 1970 The effect of fluoride on the reactions of methanesulfonates with acetylcholinesterase. Fluorides 14-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 5460001-0 1970 The effect of fluoride on the reactions of methanesulfonates with acetylcholinesterase. Mesylates 43-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 5272331-1 1970 p-Nitrobenzene diazonium fluoroborate (NDF) is a potent inhibitor of the carbamylcholine-induced depolarization of the electroplax and of acetylcholinesterase. 4-nitrobenzene diazonium tetrafluoroborate 0-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 5272331-1 1970 p-Nitrobenzene diazonium fluoroborate (NDF) is a potent inhibitor of the carbamylcholine-induced depolarization of the electroplax and of acetylcholinesterase. Carbachol 73-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 5532277-0 1970 [Effect of lithium and calcium ions on erythrocyte acetylcholinesterase activity]. Lithium 11-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 5532277-0 1970 [Effect of lithium and calcium ions on erythrocyte acetylcholinesterase activity]. Calcium 23-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 5443532-0 1970 The effect of fluoride on the reaction of acetylcholinesterase with carbamates. Fluorides 14-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 5443532-0 1970 The effect of fluoride on the reaction of acetylcholinesterase with carbamates. Carbamates 68-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 5417394-0 1970 Hydrophobic bonding of trialkyl phosphates and phosphorothiolates to acetylcholinesterase. trialkyl phosphates 23-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 5417394-0 1970 Hydrophobic bonding of trialkyl phosphates and phosphorothiolates to acetylcholinesterase. phosphorothiolates 47-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 5507658-0 1970 Dephosphorylation in vivo of brain acetylcholinesterase inhibited by isopropyl methylphosphonofluoridate (Sarin). Sarin 69-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 5413940-0 1970 Inhibition and reactivation of acetylcholinesterase modified by reaction with 1,1-dimethyl-2-phenylaziridinium ion. N,N-dimethyl-2-phenylaziridinium 78-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 5314427-0 1970 Tris-(hydroxymethyl) aminomethane as an activator of acetylcholinesterase. Tromethamine 0-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 5378376-3 1969 The kinetics of the reaction of di-(2-chloroethyl) 3-chloro-4-methylcoumarin-7-yl phosphate (haloxon) and related compounds with acetylcholinesterase were studied and found to be unusual. haloxon 32-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-149 5378376-3 1969 The kinetics of the reaction of di-(2-chloroethyl) 3-chloro-4-methylcoumarin-7-yl phosphate (haloxon) and related compounds with acetylcholinesterase were studied and found to be unusual. haloxon 93-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-149 5378376-9 1969 Haloxon also combines with acetylcholinesterase by a non-progressive reaction, producing a complex that is reversible by dilution and by high concentrations of acetylcholine and acetylthiocholine. haloxon 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 5378376-9 1969 Haloxon also combines with acetylcholinesterase by a non-progressive reaction, producing a complex that is reversible by dilution and by high concentrations of acetylcholine and acetylthiocholine. Acetylthiocholine 178-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 5378376-17 1969 These equations are applicable to reactions of acetylcholinesterase with organophosphorus compounds, carbamates etc. organophosphorus 73-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 5378376-17 1969 These equations are applicable to reactions of acetylcholinesterase with organophosphorus compounds, carbamates etc. Carbamates 101-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 5384471-0 1969 Fine structural localization of acetylcholinesterase using acetyl-beta-methylthiocholine and acetylselenocholine as substrates. acetyl-beta-(methylthio)choline 59-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 5384471-0 1969 Fine structural localization of acetylcholinesterase using acetyl-beta-methylthiocholine and acetylselenocholine as substrates. acetylselenocholine 93-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 5810051-0 1969 The inhibition of acetylcholinesterase by oxime carbamates. oxime carbamates 42-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 5816009-0 1969 The properties of acetylcholinesterase modified by interaction with the alkylating agent N,N-dimethyl-2-phenylaziridinium ion. N,N-dimethyl-2-phenylaziridinium 89-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 4306345-0 1969 The action of phenylmethylsulfonyl fluoride on human acetylcholinesterase, chymotyrpsin and trypsin. Phenylmethylsulfonyl Fluoride 14-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 5778146-0 1969 The reaction of acetylcholinesterase with methanesulfonyl esters of quaternary quinolinium compounds. methanesulfonyl esters 42-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 5778146-0 1969 The reaction of acetylcholinesterase with methanesulfonyl esters of quaternary quinolinium compounds. quaternary quinolinium compounds 68-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 4977435-0 1969 Loss of acetylcholinesterase activity in human erythrocytes treated with cephalothin. Cephalothin 73-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-28 4242432-0 1969 [Kinetic studies on the protection, by alkane-bis-ammonium and alkane-bis-amino compounds, of acetylcholinesterase against diisopropylfluorophosphate poisoning]. alkane-bis-ammonium 39-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 4242432-0 1969 [Kinetic studies on the protection, by alkane-bis-ammonium and alkane-bis-amino compounds, of acetylcholinesterase against diisopropylfluorophosphate poisoning]. alkane-bis-amino 63-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 4242432-0 1969 [Kinetic studies on the protection, by alkane-bis-ammonium and alkane-bis-amino compounds, of acetylcholinesterase against diisopropylfluorophosphate poisoning]. Isoflurophate 123-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 4178052-0 1968 Acetyl disulfide, (CH3COS)2, a major active component in the thiolacetic acid histochemical method for acetylcholinesterase. acetyl disulfide 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 4178052-0 1968 Acetyl disulfide, (CH3COS)2, a major active component in the thiolacetic acid histochemical method for acetylcholinesterase. (ch3cos)2 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 4178053-0 1968 Acetyl disulfide, (CH3COS)2, and bis-(thioacetoy) aurate (I) complex, Au(CH3CHOS)2,-histochemical substrates of unusual properties with acetylcholinesterase. acetyl disulfide 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 4178053-0 1968 Acetyl disulfide, (CH3COS)2, and bis-(thioacetoy) aurate (I) complex, Au(CH3CHOS)2,-histochemical substrates of unusual properties with acetylcholinesterase. (ch3cos)2 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 4178053-0 1968 Acetyl disulfide, (CH3COS)2, and bis-(thioacetoy) aurate (I) complex, Au(CH3CHOS)2,-histochemical substrates of unusual properties with acetylcholinesterase. bis-(thioacetoy) aurate 33-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 4178053-0 1968 Acetyl disulfide, (CH3COS)2, and bis-(thioacetoy) aurate (I) complex, Au(CH3CHOS)2,-histochemical substrates of unusual properties with acetylcholinesterase. au(ch3chos)2 70-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 5672830-0 1968 Ageing and reactivation of acetylcholinesterase inhibited with Soman and its thiocholine-like analogue. Thiocholine 77-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 5689803-0 1968 Acetylcholinesterase hydrolysis of halogen substituted acetylcholines. Halogens 35-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 5689803-0 1968 Acetylcholinesterase hydrolysis of halogen substituted acetylcholines. Acetylcholine 55-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 5689551-0 1968 Molecular aspects of the interaction of lactoyl- and glyceroylcholines with acetylcholinesterase. lactoyl 40-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 5689551-0 1968 Molecular aspects of the interaction of lactoyl- and glyceroylcholines with acetylcholinesterase. glyceroylcholines 53-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 4384537-0 1968 Potentiation of acetylcholinesterase by a series of quaternary ammonium compounds. Quaternary Ammonium Compounds 52-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 5640175-0 1968 Catecholamine and acetylcholinesterase distribution in relation to noradrenaline release. Norepinephrine 67-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 6070259-0 1967 Acetylcholinesterase inhibition by micropollutants in drinking water. Water 63-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 11947075-0 1973 Spectral evidence for the presence of tryptophan in the binding site of acetylcholinesterase. Tryptophan 38-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 4806294-0 1973 On the conditions for assaying acetylcholinesterase with 14C-acetylbetamethylcholine. 14c-acetylbetamethylcholine 57-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 5075335-0 1972 [Identification of acetylcholinesterase species of Gymnotus after fractionation of the electric organ and electrophoresis on polyacrylamide gel]. polyacrylamide 125-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 5076351-0 1972 Inhibition of acetylcholinesterase from mammals and insects by carbofuran and its related compounds and their toxicities toward these animals. Carbofuran 63-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 4539417-0 1972 Reactions between alkyl phosphates and acetylcholinesterase from different species. alkyl phosphates 18-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 5080267-0 1972 [Restoration of acetylcholinesterase activity in animals intoxicated with pinacolyl-methylphosphonofluoridate]. Soman 74-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 5037613-0 1972 Modifications of the erythrocyte membrane by glutaraldehyde: effect on acetylcholinesterase. Glutaral 45-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 5072301-0 1972 Acetylcholinesterase inhibition by substituted phenyl N-alkyl carbamates. substituted phenyl n-alkyl carbamates 35-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 5062577-0 1972 Oxime acetates: substrates for acetylcholinesterase. oxime acetates 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 5167215-0 1971 Acceleration by free carbamate of the spontaneous reactivation of carbamylated acetylcholinesterase. Carbamates 21-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 5114499-0 1971 Influence of alkane-bis-onium compounds upon the activity of the AchE and upon its inhibition by DFP. alkane-bis-onium compounds 13-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 5166494-0 1971 Ions of the rare earths as possible reactivators of acetylcholinesterase inhibited by some organophosphorus compounds. organophosphorus 91-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 4941499-0 1971 [Acetylcholinesterase activity in acute and chronic poisoning with organophosphorous inhibitions]. organophosphorous 67-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 1-21 5576158-2 1971 Tabun is a more potent inhibitor of acetylcholinesterase than is DFP, is both lipid-and water-soluble, and penetrates readily into the squid giant axon in its inhibitory form. tabun 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 5125850-0 1971 The influence of tetraethylammonium ion on the reaction between acetylcholinesterase and selected inhibitors. Tetraethylammonium 17-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 5144280-0 1971 Solubilization of acetylcholinesterase from human erythrocytes by Triton X-100 in potassium chloride solution. Octoxynol 66-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 5144280-0 1971 Solubilization of acetylcholinesterase from human erythrocytes by Triton X-100 in potassium chloride solution. Potassium Chloride 82-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 5567394-0 1971 The influence of A1 +++ on cholinesterase and acetylcholinesterase activity. a1 +++ 17-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 4941660-1 1971 The clinical manifestations of acute poisoning by organophosphorus compounds in man are in accord with, initially, the stimulation and, later, the blocking of cholinergic transmission due to acetylcholinesterase inhibition. organophosphorus 50-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 191-211 5315349-0 1971 Relationships between the structure of organophosphorus compounds and their activity as acetylcholinesterase inhibitors. Organophosphorus Compounds 39-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 5315349-1 1971 This paper discusses the relation between chemical structure and inactivation of the enzyme acetylcholinesterase (AChE) by organophosphorus esters, in terms of reactivity and steric effects. organophosphorus esters 123-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 5315349-1 1971 This paper discusses the relation between chemical structure and inactivation of the enzyme acetylcholinesterase (AChE) by organophosphorus esters, in terms of reactivity and steric effects. organophosphorus esters 123-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 5315349-3 1971 Specific examples illustrating the effect of AChE inhibition on the selective toxicity of organophosphorus esters for insects and mammals are also presented. organophosphorus esters 90-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 5315358-1 1971 Carbamate insecticides are biologically active because of their structural complementarity to the active site of acetylcholinesterase (AChE) and their consequent action as substrates with very low turnover numbers. Carbamates 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-133 5315358-1 1971 Carbamate insecticides are biologically active because of their structural complementarity to the active site of acetylcholinesterase (AChE) and their consequent action as substrates with very low turnover numbers. Carbamates 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 5315358-2 1971 Carbamates behave as synthetic neurohormones that produce their toxic action by interrupting the normal action of AChE so that acetylcholine accumulates at synaptic junctions. Carbamates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 5315358-2 1971 Carbamates behave as synthetic neurohormones that produce their toxic action by interrupting the normal action of AChE so that acetylcholine accumulates at synaptic junctions. Acetylcholine 127-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 5315358-3 1971 The necessary properties for a suitable insecticidal carbamate are lipid solubility, suitable structural complementarity to AChE, and sufficient stability to multifunction-oxidase detoxification. Carbamates 53-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 4114055-0 1971 [Isolation of acetylcholinesterase from the stroma of erythrocytes using alcohols as detergents]. Alcohols 73-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 5552250-0 1971 The use of nuclear magnetic resonance to describe the binding of atrophine analogues to acetylcholinesterase. atrophine 65-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 5275370-1 1970 Acetylcholinesterase of intact red blood cell membranes and the acetylcholine receptor at the neuromuscular junction of whole-frog sartorius muscle have been irreversibly inactivated by photo-affinity labeling with two quaternary ammonium aryl azides. quaternary ammonium aryl azides 219-250 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 11945389-0 1970 Reactivating effect of alpha,omega-bis-(4-pyridinealdoxime)-2-trans-butene dibromide on isopropyl-methylphosphonylated acetylcholinesterase. alpha,omega-bis-(4-pyridinealdoxime)-2-trans-butene dibromide 23-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 5466226-0 1970 Acetylcholinesterase substrates: beta-methylcholine esters. beta-methylcholine esters 33-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 5426683-0 1970 Inhibition of acetylcholinesterase in vitro by pentylenetetrazol. Pentylenetetrazole 47-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 4399491-0 1970 1,2-disubstituted cyclohexanes as substrates of acetylcholinesterase and muscarinic agents. 1,2-disubstituted cyclohexanes 0-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 5507637-0 1970 Sensitivity of acetylcholinesterase in spider mites to organo-phosphorus compounds. organo-phosphorus 55-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 4253834-0 1970 [Determination of acetylcholinesterase concentration by phosphorylation with paraoxon]. Paraoxon 77-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 4253843-0 1970 [Relation between inhibition of acetylcholinesterase and binding of 3H-diisopropylphosphorofluoridate under the influence of alkane-bis-ammonium compounds]. 3h-diisopropylphosphorofluoridate 68-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 4253843-0 1970 [Relation between inhibition of acetylcholinesterase and binding of 3H-diisopropylphosphorofluoridate under the influence of alkane-bis-ammonium compounds]. alkane-bis-ammonium compounds 125-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 4982085-12 1969 The assay of acetylcholinesterase was based on the formation of labelled acetate from labelled acetylcholine. Acetates 73-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-33 5264140-4 1969 N-p-phenylazophenyl-N-phenylcarbamyl fluoride, an irreversible inhibitor of acetylcholinesterase, exists as two geometric isomers which are interconvertible through the action of light. n-p-phenylazophenyl-n-phenylcarbamyl fluoride 0-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 5264140-7 1969 Similarly, levels of acetylcholinesterase activity could be photo-regulated in a completely reversible manner by means of the photochromic reversible inhibitor p-phenylazophenyltrimethylammonium chloride. 4-phenylazophenyltrimethylammonium 160-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 5388111-0 1969 Affinity and phosphorylation constants of a series of O,O-dialkyl malaoxons and paraoxons with acetylcholinesterase. o,o-dialkyl malaoxons 54-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 5260926-0 1969 Compared effects of dithiotreitol on the interaction of an affinity-labeling reagent with acetylcholinesterase and the excitable membrane of the electroplax. Dithiothreitol 20-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 5260926-2 1969 After in vitro exposure of acetylcholinesterase to DTT, TDF becomes a reversible competitive inhibitor of the enzyme, using indophenyl acetate as the substrate. Dithiothreitol 51-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 5260926-2 1969 After in vitro exposure of acetylcholinesterase to DTT, TDF becomes a reversible competitive inhibitor of the enzyme, using indophenyl acetate as the substrate. indophenyl acetate 124-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 5260926-3 1969 Both acetylcholinesterase and the macromolecular receptor of acetylcholine thus contain disulfide bonds. Disulfides 88-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-25 5786978-5 1969 It has previously been demonstrated (Rogers et al., 1966) that one-third of the DFP-sensitive sites at the endplate can be reactivated by pyridine-2-aldoxime methiodide (2-PAM)-a compound which selectively reactivates phosphorylated acetylcholinesterase. pralidoxime 138-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-253 5786978-5 1969 It has previously been demonstrated (Rogers et al., 1966) that one-third of the DFP-sensitive sites at the endplate can be reactivated by pyridine-2-aldoxime methiodide (2-PAM)-a compound which selectively reactivates phosphorylated acetylcholinesterase. pralidoxime 170-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-253 19873643-1 1969 Several properties of the enzyme acetylcholinesterase (AChE) isolated in vitro are compared with those of the membrane receptor(s) of acetylcholine expressed by the in vivo electrical response of the electroplax membrane. Acetylcholine 33-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 19873643-2 1969 AChE strongly binds in vitro effectors of the electroplax: agonists e.g., decamethonium or antagonists, e.g., d-tubocurarine and flaxedil. decamethonium 74-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 19873643-2 1969 AChE strongly binds in vitro effectors of the electroplax: agonists e.g., decamethonium or antagonists, e.g., d-tubocurarine and flaxedil. Tubocurarine 110-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 19873643-2 1969 AChE strongly binds in vitro effectors of the electroplax: agonists e.g., decamethonium or antagonists, e.g., d-tubocurarine and flaxedil. Gallamine Triethiodide 129-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 19873643-4 1969 Two classes of sites on AChE molecule account for the binding of these quaternary nitrogen containing compounds: (1) the anionic site of the active center and (2) noncatalytic "peripheral anionic centers" located outside the active center. Nitrogen 82-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 19873643-5 1969 A disulfide bond breaking agent, dithiothreitol (DTT) alters in a parallel manner the reaction of AChE and the excitable membrane of the electroplax to TDF. Disulfides 2-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 19873643-5 1969 A disulfide bond breaking agent, dithiothreitol (DTT) alters in a parallel manner the reaction of AChE and the excitable membrane of the electroplax to TDF. Dithiothreitol 33-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 19873643-5 1969 A disulfide bond breaking agent, dithiothreitol (DTT) alters in a parallel manner the reaction of AChE and the excitable membrane of the electroplax to TDF. Dithiothreitol 49-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 19873643-7 1969 Both AChE and the acetylcholine receptor thus contain disulfide bonds-they are closely related but not necessarily identical proteins. Disulfides 54-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 5257018-0 1969 On the association of tyrocidine with acetylcholinesterase. Tyrocidine 22-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 5257018-1 1969 In studies of several polypeptide antibiotics with a high affinity for a variety of biological membranes, tyrocidine was found to bind specifically to acetylcholinesterase, an enzyme localized in excitable membranes. Tyrocidine 106-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-171 5257018-3 1969 Tyrocidine reversibly inhibits acetylcholinesterase formed by homogeneous protein, but seems to have no effect on the activity of the enzyme bound to the eel electroplax membrane. Tyrocidine 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 5709790-0 1968 Inhibition of acetylcholinesterase in vitro by hemicholinium-3. Hemicholinium 3 47-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 5688122-0 1968 The inhibition of acetylcholinesterase by 2-pyridinealdoxime methyl halide. 2-pyridinealdoxime methyl halide 42-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 5690300-0 1968 The reaction of acetylcholinesterase (AChe) with some quaternary hydroxy aminophenols. quaternary hydroxy aminophenols 54-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 5690300-0 1968 The reaction of acetylcholinesterase (AChe) with some quaternary hydroxy aminophenols. quaternary hydroxy aminophenols 54-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 6082482-0 1967 Irreversible inhibition of acetylcholinesterase by dibenamine. Dibenzylchlorethamine 51-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 4888262-0 1967 [The activity of acetylcholinesterase in the blood and elimination of catecholamines in the urine in patients with peptic ulcer before and after stomach resection and in the dumping syndrome]. Catecholamines 70-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 1126334-1 1975 Treatment of human erythrocytes with non-hemolytic concentrations of tetraphenylboron causes irreversible inactivation of acetylcholinesterase, an enzyme located at or near the outer cell surface. Tetraphenylborate 69-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 1126334-2 1975 By contrast to other agents which also inactivate acetylcholinesterase activity such as 1,5-difluoro-2,4-dinitrobenzene and glutaraldehyde, tetraphenylboron does not affect the thermostability of the enzyme, alter its susceptibility to denaturation by urea or hinder the proteolytic digestion of the erythrocyte membrane. 1,5-difluoro-2,4-dinitrobenzene 88-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 5599903-0 1967 [Effect of sodium ions on the activity of acetylcholinesterase of erythrocytes]. Sodium 11-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 4172645-0 1967 A thiocholine-lead ferrocyanide method for acetylcholinesterase. Thiocholine 2-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 4172645-0 1967 A thiocholine-lead ferrocyanide method for acetylcholinesterase. hexacyanoferrate II 19-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 6035501-0 1967 The acceleration of the acetylcholinesterase catalyzed hydrolysis of acetyl fluoride. ACETYL FLUORIDE 69-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 6037683-0 1967 The reaction of acetylcholinesterase with diethylphosphoryl esters of quaternary and tertiary aminophenols. diethylphosphoryl esters 42-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 6037683-0 1967 The reaction of acetylcholinesterase with diethylphosphoryl esters of quaternary and tertiary aminophenols. Aminophenols 94-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 6022902-2 1967 Stimulation of acetylcholinesterase synthesis by actinomycin-D in the hypoglossal nerve. Dactinomycin 49-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 6034365-0 1967 The reactivation by pyridium aldoximes of phosphorylated acetylcholinesterase in the central nervous system. Phenazopyridine 20-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 5589641-0 1967 Ultrastructural demonstration of acetylcholinesterase activity of motor endplates via osmiophilic diazothioethers. diazothioethers 98-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 6010724-0 1966 [Effect of lead triethyl-chloride on cerebral and hematic acetylcholinesterase]. triethyl-chloride 16-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 5971773-0 1966 Substrate and dilution effects on the inhibition of acetylcholinesterase by carbamates. Carbamates 76-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 5971773-2 1966 The kinetics of acetylcholinesterase (EC 3.1.1.7) activity and its inhibition by eserine or by Sevin (1-naphthyl N-methylcarbamate) have been studied over the substrate concentration range 5x10(-8) to 2.5x10(-2)m. 2. Carbaryl 102-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 5969209-0 1966 The in vivo protection by gamma-aminobutyric acid against organic phosphate inhibition of AChE. gamma-Aminobutyric Acid 26-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 5969209-0 1966 The in vivo protection by gamma-aminobutyric acid against organic phosphate inhibition of AChE. Organophosphates 58-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 5961538-0 1966 A comment on the binding of quaternary ammonium inhibitors at the anionic site of acetylcholinesterase. quaternary ammonium 28-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 5911531-4 1966 The dealkylation rates have been measured for acetylcholinesterase inhibited by isopropyl, sec.-butyl, 1,2-dimethylpropyl, 1,2,2-trimethylpropyl and cyclohexyl methylphosphonofluoridate, and by di-isopropyl phosphorofluoridate; they are first-order under the conditions used. Isoflurophate 194-226 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 4962039-0 1966 Pb-thiocholine techniques for the electron histochemical localization of acetylcholinesterase. pb-thiocholine 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 5941985-0 1966 Spectrophotometric study of the acetylcholinesterase-catalyzed hydrolysis of 1-methyl-acetoxyquinolinium iodides. 1-methyl-acetoxyquinolinium iodides 77-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 5983751-0 1966 [Studies on the reproducibility of the determination of acetylcholinesterase by the hydroxamic acid method. Hydroxamic Acids 84-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 5873635-0 1965 [Acetylcholinesterase and the bioelectrical activity of the brain under the action of eserine and galanthamine in animals with premesencephalic section of the brain]. Physostigmine 86-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-21 5873635-0 1965 [Acetylcholinesterase and the bioelectrical activity of the brain under the action of eserine and galanthamine in animals with premesencephalic section of the brain]. Galantamine 98-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-21 5833399-0 1965 Affinity of benzoquinonium and ambenonium derivatives for the acetylcholine receptor, tested on the electroplax, and for acetylcholinesterase in solution. benzoquinonium 12-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 5833399-0 1965 Affinity of benzoquinonium and ambenonium derivatives for the acetylcholine receptor, tested on the electroplax, and for acetylcholinesterase in solution. Ambenonium Chloride 31-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 14327094-0 1965 [ON BEHAVIOR OF ATP AND OF ACETYLCHOLINESTERASE OF THE SPINAL CORD IN PORPHYRIA DUE TO ALLYL-ISOPROPYL-ACETYLCARBAMIDE]. apronalide 87-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 14249356-0 1964 A TECHNIQUE FOR THE DEMONSTRATION OF ACETYLCHOLINESTERASE ACTIVITY IN THE INNER EAR AFTER DECALCIFICATION WITH EDTA. Edetic Acid 111-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 14235343-0 1964 ACETYLCHOLINESTERASE: TRIMETHYLAMMONIUM-ION INHIBITION OF DEACETYLATION. Cetrimonium 22-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 14250483-0 1964 [EXPERIMENTAL STUDY ON THE ACTION OF ISOFLUOROPHATE ON ACETYLCHOLINESTERASE OF THE MOTOR ENDPLATES OF NORMAL AND DENERVATED STRIATED MUSCLES]. Isoflurophate 37-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 14223684-1 1964 THE DISCHLORIDE OF BIS-(4-HYDROXYIMINOMETHYL-1-PYRIDINIUM-METHYL)-ETHER (LUEH6), A NEW REACTIVATOR OF ACETYLCHOLINESTERASE INHIBITED BY ORGANIC PHOSPHORIC ACID ESTERS]. dischloride 4-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 14223684-1 1964 THE DISCHLORIDE OF BIS-(4-HYDROXYIMINOMETHYL-1-PYRIDINIUM-METHYL)-ETHER (LUEH6), A NEW REACTIVATOR OF ACETYLCHOLINESTERASE INHIBITED BY ORGANIC PHOSPHORIC ACID ESTERS]. Organophosphates 144-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 14106375-0 1964 METAL CHELATES AS POTENTIAL REACTIVATORS OF ORGANIC PHOSPHATE POISONED ACETYLCHOLINESTERASE. Metals 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 14098449-0 1963 EFFECT OF NITROGEN MUSTARD ON ERYTHROCYTE ACETYLCHOLINESTERASE. Nitrogen 10-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 14099400-0 1963 [ON THE INHIBITION OF THE HISTOCHEMICAL ACETYLCHOLINESTERASE REACTION ON MOTOR END-PLATES BY INJECTIONS OF NEOSTIGMINE AND PHYSOSTIGMINE]. Neostigmine 107-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 14099400-0 1963 [ON THE INHIBITION OF THE HISTOCHEMICAL ACETYLCHOLINESTERASE REACTION ON MOTOR END-PLATES BY INJECTIONS OF NEOSTIGMINE AND PHYSOSTIGMINE]. Physostigmine 123-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 14068276-0 1963 A COMPARATIVE STUDY OF SOME PYRIDINIUM OXIMES AS REACTIVATORS OF PHOSPHORYLATED ACETYLCHOLINESTERASE AND AS ANTIDOTES IN SARIN POISONING. pyridinium oximes 28-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 14011954-0 1963 The reactivation of acetylcholinesterase after inhibition by methanesulfonic acid esters. methanesulfonic acid esters 61-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 14058030-0 1963 [ON THE EFFECT OF SOME DERIVATIVES OF ALIPHATIC TRIMETHYLBETAINE ON ACETYLCHOLINESTERASE AND ON THE HYDROLYSIS OF BETAINE ESTERS]. aliphatic 38-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 14058030-0 1963 [ON THE EFFECT OF SOME DERIVATIVES OF ALIPHATIC TRIMETHYLBETAINE ON ACETYLCHOLINESTERASE AND ON THE HYDROLYSIS OF BETAINE ESTERS]. Betaine 48-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 14033211-0 1962 Esters of methanesulfonic acid as irreversible inhibitors of acetylcholinesterase. Esters 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 14033211-0 1962 Esters of methanesulfonic acid as irreversible inhibitors of acetylcholinesterase. methanesulfonic acid 10-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 13895353-0 1961 Studies on blockade of single nodes of Ranvier and of the acetylcholinesterase system by cyclic aromatic esters. cyclic aromatic esters 89-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 13785663-0 1961 Carbamyl derivatives of acetylcholinesterase. Aldicarb 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 13769895-0 1961 The brain ACh-AChE-ChA system in respiratory control. Acetylcholine 10-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 13782920-0 1960 Inhibition of acetylcholinesterase by cetyltrimethylammonium bromide. Cetrimonium 38-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 13757475-1 1960 The return of acetylcholinesterase activity was studied in several cholinergic structures in the cat after irreversible inactivation by diisopropylfluoro-phosphate. Isoflurophate 136-163 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 13826989-0 1960 Competitive inhibition of acetylcholinesterase by several thiazolines and oxazolines. thiazolines 58-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 13826989-0 1960 Competitive inhibition of acetylcholinesterase by several thiazolines and oxazolines. oxazolines 74-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 13817665-0 1960 [Relations between testosterone and serum acetylcholinesterase in women with uterine fibroma]. Testosterone 19-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 13825217-0 1959 The responses of acetylcholinesterase and conduction in bull-frog sciatic nerve to the stereochemistry of amino alcohol derivatives. Amino Alcohols 106-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 13845452-0 1959 Acetylcholinesterase inhibitory activities of muscarine and muscarone derivatives. muscarone 60-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 14402643-0 1959 [Cardioplegia induced by acetyl choline and its immediate, effective release by synthetic acetylcholinesterase]. Acetylcholine 25-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 13664684-4 1959 Following total inactivation of the ganglionic acetylcholinesterase by intravenously administered di-isopropyl fluorophosphate, the reappearance of the enzyme in vivo occurred at the same cytoplasmic sites prior to its reappearance at the cell membrane or preganglionic axonal terminations. Isoflurophate 98-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 13662448-0 1959 [Independence of the effects of a selective acetylcholinesterase inhibitor (CT 3318) on striated muscle from its antienzymatic activity]. CT 3318 76-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 13641422-0 1959 Potassium transport in the acetylcholinesterase-deficient erythrocytes of paroxysmal nocturnal hemoglobinuria (PNH). Potassium 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 13609607-0 1958 Acetylcholinesterase, acid phosphatase, and succinic dehydrogenase in the hypothalamic magnocellular nuclei after serotonin administration. Serotonin 114-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 13587304-0 1958 Colorimetric estimation of some cholinergic esters; application to the demonstration of acetylcholinesterase activity. Esters 44-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 13574144-0 1958 Acetylcholinesterase, acid phosphatase, and succinic dehydrogenase in the hypothalamic magnocellular nuclei after chlorpromazine administration; histochemical studies. Chlorpromazine 114-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 13418739-0 1957 Inhibition of acetylcholinesterase by reserpine in suspension. Reserpine 38-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 6070126-0 1967 Effect of pH on inhibition and spontaneous reactivation of acetylcholinesterase treated with esters of phosphorus acids and of carbamic acids. Esters 93-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 6070126-0 1967 Effect of pH on inhibition and spontaneous reactivation of acetylcholinesterase treated with esters of phosphorus acids and of carbamic acids. Phosphorus Acids 103-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 6070126-0 1967 Effect of pH on inhibition and spontaneous reactivation of acetylcholinesterase treated with esters of phosphorus acids and of carbamic acids. Carbamates 127-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 6070126-2 1967 The second-order rate constants of inhibition, k(a), of acetylcholinesterase were measured at pH values between 5.5 and 10.5 for two esters of phosphorus acids and five esters of carbamic acids. Esters 133-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 6070126-2 1967 The second-order rate constants of inhibition, k(a), of acetylcholinesterase were measured at pH values between 5.5 and 10.5 for two esters of phosphorus acids and five esters of carbamic acids. Phosphorus Acids 143-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 6070126-2 1967 The second-order rate constants of inhibition, k(a), of acetylcholinesterase were measured at pH values between 5.5 and 10.5 for two esters of phosphorus acids and five esters of carbamic acids. Carbamates 179-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 13314695-0 1955 The interaction of tensilon and neostigmine with acetylcholinesterase. Edrophonium 19-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 13314695-0 1955 The interaction of tensilon and neostigmine with acetylcholinesterase. Neostigmine 32-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 14392160-0 1955 Microdiffusion of acetic acid as an assay for acetylcholinesterase. Acetic Acid 18-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 13081156-0 1953 Mechanism of hydrolysis of acetylcholine catalyzed by acetylcholinesterase and by hydroxide ion. Acetylcholine 27-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 14350811-0 1955 Reactivation of acetylcholinesterase inhibited by alkylphosphates. alkylphosphates 50-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 14904446-0 1951 Quaternary ammonium salts as inhibitors of acetylcholinesterase. quaternary ammonium salts 0-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 33979725-1 2021 The interactions between selected molecules (piperine, tacrine, curcumin and silibinin) and proteins (acetylcholinesterase and bovine serum albumin) were investigated by Fluorescence spectroscopy, molecular docking, molecular dynamics, free energy calculation and non-covalent interaction analysis. Silybin 77-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 33979725-3 2021 The steady-state emission spectrum results showed that presence of static quenching mode for piperine, tacrine, curcumin, silibinin molecules with BSA and AChE complexes separately and this excitation-emission matrix analysis suggest that formation of ground-state complex between piperine, tacrine, curcumin, silibinin drugs and both BSA, AChE protein molecules. piperine 93-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 33979725-3 2021 The steady-state emission spectrum results showed that presence of static quenching mode for piperine, tacrine, curcumin, silibinin molecules with BSA and AChE complexes separately and this excitation-emission matrix analysis suggest that formation of ground-state complex between piperine, tacrine, curcumin, silibinin drugs and both BSA, AChE protein molecules. Tacrine 103-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 33979725-3 2021 The steady-state emission spectrum results showed that presence of static quenching mode for piperine, tacrine, curcumin, silibinin molecules with BSA and AChE complexes separately and this excitation-emission matrix analysis suggest that formation of ground-state complex between piperine, tacrine, curcumin, silibinin drugs and both BSA, AChE protein molecules. Curcumin 112-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 33979725-3 2021 The steady-state emission spectrum results showed that presence of static quenching mode for piperine, tacrine, curcumin, silibinin molecules with BSA and AChE complexes separately and this excitation-emission matrix analysis suggest that formation of ground-state complex between piperine, tacrine, curcumin, silibinin drugs and both BSA, AChE protein molecules. Curcumin 112-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 340-344 33979725-3 2021 The steady-state emission spectrum results showed that presence of static quenching mode for piperine, tacrine, curcumin, silibinin molecules with BSA and AChE complexes separately and this excitation-emission matrix analysis suggest that formation of ground-state complex between piperine, tacrine, curcumin, silibinin drugs and both BSA, AChE protein molecules. Silybin 122-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 33979725-3 2021 The steady-state emission spectrum results showed that presence of static quenching mode for piperine, tacrine, curcumin, silibinin molecules with BSA and AChE complexes separately and this excitation-emission matrix analysis suggest that formation of ground-state complex between piperine, tacrine, curcumin, silibinin drugs and both BSA, AChE protein molecules. Silybin 122-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 340-344 33979725-3 2021 The steady-state emission spectrum results showed that presence of static quenching mode for piperine, tacrine, curcumin, silibinin molecules with BSA and AChE complexes separately and this excitation-emission matrix analysis suggest that formation of ground-state complex between piperine, tacrine, curcumin, silibinin drugs and both BSA, AChE protein molecules. piperine 281-289 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 33979725-3 2021 The steady-state emission spectrum results showed that presence of static quenching mode for piperine, tacrine, curcumin, silibinin molecules with BSA and AChE complexes separately and this excitation-emission matrix analysis suggest that formation of ground-state complex between piperine, tacrine, curcumin, silibinin drugs and both BSA, AChE protein molecules. piperine 281-289 acetylcholinesterase (Cartwright blood group) Homo sapiens 340-344 33979725-3 2021 The steady-state emission spectrum results showed that presence of static quenching mode for piperine, tacrine, curcumin, silibinin molecules with BSA and AChE complexes separately and this excitation-emission matrix analysis suggest that formation of ground-state complex between piperine, tacrine, curcumin, silibinin drugs and both BSA, AChE protein molecules. Tacrine 291-298 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 33979725-3 2021 The steady-state emission spectrum results showed that presence of static quenching mode for piperine, tacrine, curcumin, silibinin molecules with BSA and AChE complexes separately and this excitation-emission matrix analysis suggest that formation of ground-state complex between piperine, tacrine, curcumin, silibinin drugs and both BSA, AChE protein molecules. Curcumin 300-308 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 33979725-3 2021 The steady-state emission spectrum results showed that presence of static quenching mode for piperine, tacrine, curcumin, silibinin molecules with BSA and AChE complexes separately and this excitation-emission matrix analysis suggest that formation of ground-state complex between piperine, tacrine, curcumin, silibinin drugs and both BSA, AChE protein molecules. Silybin 310-319 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 33979725-4 2021 And, the binding model from molecular docking analysis of both BSA and AChE with these molecules clearly displayed non-covalent interactions (hydrogen bonding and hydrophobic interactions) which played a significant role in the binding mechanism. Hydrogen 142-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 33831382-4 2021 The results have shown that memantine and Mrz 2/373 exerted concentration-dependent inhibition of AChE, with Mrz 2/373 being a more potent inhibitor than the parent compound. Memantine 28-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 6076610-0 1967 The reaction of acetylcholinesterase with O-dimethylcarbamyl esters of quaternary quinolinium compounds. o-dimethylcarbamyl esters 42-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 6076610-0 1967 The reaction of acetylcholinesterase with O-dimethylcarbamyl esters of quaternary quinolinium compounds. quaternary quinolinium compounds 71-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 33930485-0 2021 Chlorpyrifos induces cell proliferation in MCF-7 and MDA-MB-231 cells, through cholinergic and Wnt/beta-catenin signaling disruption, AChE-R upregulation and oxidative stress generation after single and repeated treatment. Chlorpyrifos 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 32362189-2 2021 Herein, we investigated inhibition effects of Tamoxifen (TAM), Isoprenaline (ISO), Chlorpromazines (CPZ) and Carbamazepine (CBZ) on GST, AChE, BChE and then molecular structures and active sides of the tested drugs by molecular docking process. Isoproterenol 77-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 32362189-2 2021 Herein, we investigated inhibition effects of Tamoxifen (TAM), Isoprenaline (ISO), Chlorpromazines (CPZ) and Carbamazepine (CBZ) on GST, AChE, BChE and then molecular structures and active sides of the tested drugs by molecular docking process. Chlorpromazine 83-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 32362189-5 2021 Besides, Isoproterenol drug with the Ki value of 51.80 +- 9.44 nM was found to be the most effective inhibitor on the AChE enzyme. Isoproterenol 9-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 32364046-0 2021 To Be Ionized or Not to Be Ionized: The Vital Role of Physicochemical Properties of Galbanic Acid Derivatives in AChE Assay. galbanic acid 84-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 32364046-5 2021 Galbanic acid as a natural compound with a sesquiterpene coumarin scaffold is a weak inhibitor of AChE. galbanic acid 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 32364046-5 2021 Galbanic acid as a natural compound with a sesquiterpene coumarin scaffold is a weak inhibitor of AChE. Sesquiterpenes 43-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 32364046-5 2021 Galbanic acid as a natural compound with a sesquiterpene coumarin scaffold is a weak inhibitor of AChE. coumarin 57-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 32364046-7 2021 We performed in vitro and in silico studies on galbanic acid, methyl and ethyl galbanates as AChE inhibitors. galbanic acid 47-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 32364046-7 2021 We performed in vitro and in silico studies on galbanic acid, methyl and ethyl galbanates as AChE inhibitors. ethyl galbanates 73-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 32364046-8 2021 The order of inhibitory effect on AChE was obtained as ethyl galbanate ~ methyl galbanate > galbanic acid. Ethyl galbanate 55-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 32364046-8 2021 The order of inhibitory effect on AChE was obtained as ethyl galbanate ~ methyl galbanate > galbanic acid. methyl galbanate 73-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 32364046-8 2021 The order of inhibitory effect on AChE was obtained as ethyl galbanate ~ methyl galbanate > galbanic acid. galbanic acid 92-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 33992880-7 2021 Interestingly, the different types of components in the herbs exhibited selectivity for different targets: flavanone glycosides are effective on alpha-glucosidase but ineffective on acetylcholinesterase; polymethoxyflavonoids are effective on acetylcholinesterase but ineffective on alpha-glucosidase. flavanone glycosides 107-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 243-263 33601648-2 2021 OPs effectively reduce the production of thiocholine in the acetylcholinesterase/acetylthiocholine reaction by inhibiting the activity of acetylcholinesterase. Thiocholine 41-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 33601648-2 2021 OPs effectively reduce the production of thiocholine in the acetylcholinesterase/acetylthiocholine reaction by inhibiting the activity of acetylcholinesterase. Thiocholine 41-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 33601648-2 2021 OPs effectively reduce the production of thiocholine in the acetylcholinesterase/acetylthiocholine reaction by inhibiting the activity of acetylcholinesterase. Acetylthiocholine 81-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 33601648-2 2021 OPs effectively reduce the production of thiocholine in the acetylcholinesterase/acetylthiocholine reaction by inhibiting the activity of acetylcholinesterase. Acetylthiocholine 81-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 33831382-4 2021 The results have shown that memantine and Mrz 2/373 exerted concentration-dependent inhibition of AChE, with Mrz 2/373 being a more potent inhibitor than the parent compound. piperidine-1-carboximidamide 42-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 33831382-5 2021 Addition of soman 7.5 nmol/l induced gradual AChE inhibition that became almost complete after 20 min. Soman 12-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 33831382-6 2021 Memantine (0.1, 0.5 and 1 mmol/l) and Mrz 2/373 (0.1, 0.5 and 1 mmol/l) concentration-dependently slowed down the AChE inhibition. Memantine 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 33831382-6 2021 Memantine (0.1, 0.5 and 1 mmol/l) and Mrz 2/373 (0.1, 0.5 and 1 mmol/l) concentration-dependently slowed down the AChE inhibition. piperidine-1-carboximidamide 38-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 33831382-7 2021 After 30 min of incubation of AChE with soman, 5 min of aging and 20 min of reactivation by asoxime (HI-6 dichloride), AChE activity was 8.1% in control medium, 30.7% and 41.9% after addition of 1 and 10 mmol/l memantine, and 16.1% after addition of 1 mmol/l Mrz 2/373. asoxime 92-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 33831382-7 2021 After 30 min of incubation of AChE with soman, 5 min of aging and 20 min of reactivation by asoxime (HI-6 dichloride), AChE activity was 8.1% in control medium, 30.7% and 41.9% after addition of 1 and 10 mmol/l memantine, and 16.1% after addition of 1 mmol/l Mrz 2/373. asoxime chloride 101-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 33831382-7 2021 After 30 min of incubation of AChE with soman, 5 min of aging and 20 min of reactivation by asoxime (HI-6 dichloride), AChE activity was 8.1% in control medium, 30.7% and 41.9% after addition of 1 and 10 mmol/l memantine, and 16.1% after addition of 1 mmol/l Mrz 2/373. Memantine 211-220 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 33831382-8 2021 It was concluded that it is possible that memantine and Mrz 2/373 can prevent AChE from inhibition by soman, which could, along with known memantine"s neuroprotective activity, explain its potent antidotal effect in soman poisoning. Memantine 42-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 33831382-8 2021 It was concluded that it is possible that memantine and Mrz 2/373 can prevent AChE from inhibition by soman, which could, along with known memantine"s neuroprotective activity, explain its potent antidotal effect in soman poisoning. piperidine-1-carboximidamide 56-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 33831382-8 2021 It was concluded that it is possible that memantine and Mrz 2/373 can prevent AChE from inhibition by soman, which could, along with known memantine"s neuroprotective activity, explain its potent antidotal effect in soman poisoning. Soman 102-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 33831382-8 2021 It was concluded that it is possible that memantine and Mrz 2/373 can prevent AChE from inhibition by soman, which could, along with known memantine"s neuroprotective activity, explain its potent antidotal effect in soman poisoning. Memantine 139-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 33831382-9 2021 The potential effect on aging of the soman-AChE complex warrants further studies. Soman 37-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 34047061-2 2021 Herein, twenty-one novel dantrolene-like hydrazide and hydrazone analogues were synthesized with the aim of exploring structure-activity relationships (SARs) for the inhibition of human monoamine oxidases (MAOs) and acetylcholinesterase (AChE), two well-established target enzymes for anti-AD drugs. Dantrolene 25-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 238-242 34047061-2 2021 Herein, twenty-one novel dantrolene-like hydrazide and hydrazone analogues were synthesized with the aim of exploring structure-activity relationships (SARs) for the inhibition of human monoamine oxidases (MAOs) and acetylcholinesterase (AChE), two well-established target enzymes for anti-AD drugs. Dantrolene 25-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 216-236 34047146-0 2021 New indane derivatives containing 2-hydrazinothiazole as potential acetylcholinesterase and monoamine oxidase-B inhibitors. indan 4-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 34047146-0 2021 New indane derivatives containing 2-hydrazinothiazole as potential acetylcholinesterase and monoamine oxidase-B inhibitors. 2-Hydrazinylthiazole 34-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 34037936-5 2021 This metabolite was also significantly negatively correlated with Er-AChE, indicating effects of pyrethroid pesticides on the acetylcholine system even at concentrations below the ADI. Acetylcholine 126-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 34047061-3 2021 With few exceptions, the newly synthesized compounds exhibited selectivity toward MAO B over either MAO A and AChE, with the secondary aldimine 9 and phenylhydrazone 20 attaining IC50 values of 0.68 and 0.81 muM, respectively. phenylhydrazone 150-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 34033838-0 2021 Binding interaction of protoberberine alkaloids against acetylcholinesterase (AChE) using molecular dynamics simulations and QM/MM calculations. protoberberine alkaloids 23-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 34033838-0 2021 Binding interaction of protoberberine alkaloids against acetylcholinesterase (AChE) using molecular dynamics simulations and QM/MM calculations. protoberberine alkaloids 23-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 34033838-3 2021 Protoberberine alkaloids isolated from natural resources have previously been reported as potent AChE inhibitors. protoberberine alkaloids 0-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 34033838-4 2021 In order to gain insights into how these alkaloids could inhibit AChE, berberine, palmatine, and cyclanoline were selected to investigate in terms of binding orientation and their key interactions with AChE using molecular docking and molecular dynamics simulations and quantum chemical calculations. Alkaloids 41-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 34033838-4 2021 In order to gain insights into how these alkaloids could inhibit AChE, berberine, palmatine, and cyclanoline were selected to investigate in terms of binding orientation and their key interactions with AChE using molecular docking and molecular dynamics simulations and quantum chemical calculations. Alkaloids 41-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-206 34033838-4 2021 In order to gain insights into how these alkaloids could inhibit AChE, berberine, palmatine, and cyclanoline were selected to investigate in terms of binding orientation and their key interactions with AChE using molecular docking and molecular dynamics simulations and quantum chemical calculations. Berberine 71-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 34033838-4 2021 In order to gain insights into how these alkaloids could inhibit AChE, berberine, palmatine, and cyclanoline were selected to investigate in terms of binding orientation and their key interactions with AChE using molecular docking and molecular dynamics simulations and quantum chemical calculations. Berberine 71-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-206 34033838-4 2021 In order to gain insights into how these alkaloids could inhibit AChE, berberine, palmatine, and cyclanoline were selected to investigate in terms of binding orientation and their key interactions with AChE using molecular docking and molecular dynamics simulations and quantum chemical calculations. palmatine 82-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-206 34033838-4 2021 In order to gain insights into how these alkaloids could inhibit AChE, berberine, palmatine, and cyclanoline were selected to investigate in terms of binding orientation and their key interactions with AChE using molecular docking and molecular dynamics simulations and quantum chemical calculations. cyclanoline 97-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-206 34052739-4 2021 Imidazo[2,1-b][1,3,4]thiadiazoles demonstrated low nanomolar inhibitory activity against hCA I, hCA II, and AChE (KIs are in the range of 23.44-105.50 nM, 10.32-104.70 nM, and 20.52-54.06 nM, respectively). imidazo(2,1-b)(1,3,4)thiadiazole 0-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 34021689-2 2021 Acetylcholinesterase inhibitors (ACEI) like pyridostigmine increase gastro-intestinal (GI) motility through a cholinergic anti-inflammatory pathway (CAIP). Pyridostigmine Bromide 44-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 34024109-0 2021 Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer"s Disease. Tacrine 19-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 34024109-0 2021 Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer"s Disease. Pyrimidinones 27-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 34018740-6 2021 Further, MnNFs-Ru are employed for the homogeneous ECL determination of OPs, where acetylcholinesterase (AChE) catalyzes the hydrolysis of acetylthiocholine (ATCh) into thiocholine, which in turn decomposes MnNFs of MnNFs-Ru into Mn2+, and OPs inhibit AChE activity. OPS 72-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 34029971-3 2021 Conjugates were moderate inhibitors of equine and human BChE with negligible fluctuation in anti-BChE activity, whereas anti-AChE activity was substantially dependent on N4-substitution of the piperazine ring. Piperazine 193-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 34018740-6 2021 Further, MnNFs-Ru are employed for the homogeneous ECL determination of OPs, where acetylcholinesterase (AChE) catalyzes the hydrolysis of acetylthiocholine (ATCh) into thiocholine, which in turn decomposes MnNFs of MnNFs-Ru into Mn2+, and OPs inhibit AChE activity. OPS 72-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 34018740-6 2021 Further, MnNFs-Ru are employed for the homogeneous ECL determination of OPs, where acetylcholinesterase (AChE) catalyzes the hydrolysis of acetylthiocholine (ATCh) into thiocholine, which in turn decomposes MnNFs of MnNFs-Ru into Mn2+, and OPs inhibit AChE activity. OPS 72-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 252-256 34018740-6 2021 Further, MnNFs-Ru are employed for the homogeneous ECL determination of OPs, where acetylcholinesterase (AChE) catalyzes the hydrolysis of acetylthiocholine (ATCh) into thiocholine, which in turn decomposes MnNFs of MnNFs-Ru into Mn2+, and OPs inhibit AChE activity. Acetylthiocholine 139-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 34018740-6 2021 Further, MnNFs-Ru are employed for the homogeneous ECL determination of OPs, where acetylcholinesterase (AChE) catalyzes the hydrolysis of acetylthiocholine (ATCh) into thiocholine, which in turn decomposes MnNFs of MnNFs-Ru into Mn2+, and OPs inhibit AChE activity. Acetylthiocholine 139-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 34018740-6 2021 Further, MnNFs-Ru are employed for the homogeneous ECL determination of OPs, where acetylcholinesterase (AChE) catalyzes the hydrolysis of acetylthiocholine (ATCh) into thiocholine, which in turn decomposes MnNFs of MnNFs-Ru into Mn2+, and OPs inhibit AChE activity. Acetylthiocholine 139-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 252-256 34018740-6 2021 Further, MnNFs-Ru are employed for the homogeneous ECL determination of OPs, where acetylcholinesterase (AChE) catalyzes the hydrolysis of acetylthiocholine (ATCh) into thiocholine, which in turn decomposes MnNFs of MnNFs-Ru into Mn2+, and OPs inhibit AChE activity. Acetylthiocholine 158-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 34018740-6 2021 Further, MnNFs-Ru are employed for the homogeneous ECL determination of OPs, where acetylcholinesterase (AChE) catalyzes the hydrolysis of acetylthiocholine (ATCh) into thiocholine, which in turn decomposes MnNFs of MnNFs-Ru into Mn2+, and OPs inhibit AChE activity. Acetylthiocholine 158-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 34018740-6 2021 Further, MnNFs-Ru are employed for the homogeneous ECL determination of OPs, where acetylcholinesterase (AChE) catalyzes the hydrolysis of acetylthiocholine (ATCh) into thiocholine, which in turn decomposes MnNFs of MnNFs-Ru into Mn2+, and OPs inhibit AChE activity. Acetylthiocholine 158-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 252-256 34018740-6 2021 Further, MnNFs-Ru are employed for the homogeneous ECL determination of OPs, where acetylcholinesterase (AChE) catalyzes the hydrolysis of acetylthiocholine (ATCh) into thiocholine, which in turn decomposes MnNFs of MnNFs-Ru into Mn2+, and OPs inhibit AChE activity. Thiocholine 145-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 34018740-6 2021 Further, MnNFs-Ru are employed for the homogeneous ECL determination of OPs, where acetylcholinesterase (AChE) catalyzes the hydrolysis of acetylthiocholine (ATCh) into thiocholine, which in turn decomposes MnNFs of MnNFs-Ru into Mn2+, and OPs inhibit AChE activity. Thiocholine 145-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 34018740-6 2021 Further, MnNFs-Ru are employed for the homogeneous ECL determination of OPs, where acetylcholinesterase (AChE) catalyzes the hydrolysis of acetylthiocholine (ATCh) into thiocholine, which in turn decomposes MnNFs of MnNFs-Ru into Mn2+, and OPs inhibit AChE activity. Manganese(2+) 230-234 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 34018740-6 2021 Further, MnNFs-Ru are employed for the homogeneous ECL determination of OPs, where acetylcholinesterase (AChE) catalyzes the hydrolysis of acetylthiocholine (ATCh) into thiocholine, which in turn decomposes MnNFs of MnNFs-Ru into Mn2+, and OPs inhibit AChE activity. Manganese(2+) 230-234 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 34019427-1 2021 Oxime-based molecules are used for the treatment of patients to reactivate acetylcholinesterase (AChE) function after organophosphate intoxication. Oximes 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 34019427-1 2021 Oxime-based molecules are used for the treatment of patients to reactivate acetylcholinesterase (AChE) function after organophosphate intoxication. Oximes 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 34019427-1 2021 Oxime-based molecules are used for the treatment of patients to reactivate acetylcholinesterase (AChE) function after organophosphate intoxication. Organophosphates 118-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 34019427-1 2021 Oxime-based molecules are used for the treatment of patients to reactivate acetylcholinesterase (AChE) function after organophosphate intoxication. Organophosphates 118-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 33957044-1 2021 Organophosphorus pesticides (OPs) can inhibit the activity of acetylcholinesterase (AChE) to induce neurological diseases. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 34029971-4 2021 Compounds with para-substituted aromatic moieties (5g, 5h, and bis-amiridine 7) had the highest anti-AChE activity in the low micromolar range. 5h 55-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 34029971-4 2021 Compounds with para-substituted aromatic moieties (5g, 5h, and bis-amiridine 7) had the highest anti-AChE activity in the low micromolar range. bis-amiridine 63-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 34029971-5 2021 Top-ranked compound 5h, N-(2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-yl)-2-[4-(4-nitro-phenyl)-piperazin-1-yl]-acetamide, had an IC50 for AChE = 1.83 +- 0.03 muM (Ki = 1.50 +- 0.12 and alphaKi = 2.58 +- 0.23 muM). 5h 20-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 34029971-7 2021 In agreement with analysis of inhibition kinetics and molecular modeling studies, the lead compounds were found to bind effectively to the peripheral anionic site of AChE and displace propidium, indicating their potential to block AChE-induced beta-amyloid aggregation. Propidium 184-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 34029971-7 2021 In agreement with analysis of inhibition kinetics and molecular modeling studies, the lead compounds were found to bind effectively to the peripheral anionic site of AChE and displace propidium, indicating their potential to block AChE-induced beta-amyloid aggregation. Propidium 184-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 231-235 33957044-1 2021 Organophosphorus pesticides (OPs) can inhibit the activity of acetylcholinesterase (AChE) to induce neurological diseases. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 33957044-7 2021 Thus, on the basis of the inhibition of AChE activity by OPs, a fluorescence-colorimetric dual-signal biosensor was established. OPS 57-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 33961403-4 2021 Interestingly, S-S-AuNCs displayed a unique response to thiol compounds and low pH values and were thus pioneered as a high-efficiency sensor for OPs based on acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylthiocholine into thiocholine and CH3COOH and OP inhibition of AChE activity. Sulfhydryl Compounds 56-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 33961403-4 2021 Interestingly, S-S-AuNCs displayed a unique response to thiol compounds and low pH values and were thus pioneered as a high-efficiency sensor for OPs based on acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylthiocholine into thiocholine and CH3COOH and OP inhibition of AChE activity. Sulfhydryl Compounds 56-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 33961403-4 2021 Interestingly, S-S-AuNCs displayed a unique response to thiol compounds and low pH values and were thus pioneered as a high-efficiency sensor for OPs based on acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylthiocholine into thiocholine and CH3COOH and OP inhibition of AChE activity. Sulfhydryl Compounds 56-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 279-283 33961403-4 2021 Interestingly, S-S-AuNCs displayed a unique response to thiol compounds and low pH values and were thus pioneered as a high-efficiency sensor for OPs based on acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylthiocholine into thiocholine and CH3COOH and OP inhibition of AChE activity. Acetylthiocholine 211-228 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 33961403-4 2021 Interestingly, S-S-AuNCs displayed a unique response to thiol compounds and low pH values and were thus pioneered as a high-efficiency sensor for OPs based on acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylthiocholine into thiocholine and CH3COOH and OP inhibition of AChE activity. Acetylthiocholine 211-228 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 33961403-4 2021 Interestingly, S-S-AuNCs displayed a unique response to thiol compounds and low pH values and were thus pioneered as a high-efficiency sensor for OPs based on acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylthiocholine into thiocholine and CH3COOH and OP inhibition of AChE activity. Acetylthiocholine 211-228 acetylcholinesterase (Cartwright blood group) Homo sapiens 279-283 33961403-4 2021 Interestingly, S-S-AuNCs displayed a unique response to thiol compounds and low pH values and were thus pioneered as a high-efficiency sensor for OPs based on acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylthiocholine into thiocholine and CH3COOH and OP inhibition of AChE activity. Thiocholine 217-228 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 33961403-4 2021 Interestingly, S-S-AuNCs displayed a unique response to thiol compounds and low pH values and were thus pioneered as a high-efficiency sensor for OPs based on acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylthiocholine into thiocholine and CH3COOH and OP inhibition of AChE activity. Thiocholine 217-228 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 33961403-4 2021 Interestingly, S-S-AuNCs displayed a unique response to thiol compounds and low pH values and were thus pioneered as a high-efficiency sensor for OPs based on acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylthiocholine into thiocholine and CH3COOH and OP inhibition of AChE activity. Thiocholine 217-228 acetylcholinesterase (Cartwright blood group) Homo sapiens 279-283 33961403-4 2021 Interestingly, S-S-AuNCs displayed a unique response to thiol compounds and low pH values and were thus pioneered as a high-efficiency sensor for OPs based on acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylthiocholine into thiocholine and CH3COOH and OP inhibition of AChE activity. Acetic Acid 250-257 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 33961403-4 2021 Interestingly, S-S-AuNCs displayed a unique response to thiol compounds and low pH values and were thus pioneered as a high-efficiency sensor for OPs based on acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylthiocholine into thiocholine and CH3COOH and OP inhibition of AChE activity. Acetic Acid 250-257 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 33400519-0 2021 The Antiviral Drug Tilorone Is a Potent and Selective Inhibitor of Acetylcholinesterase. Tilorone 19-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 33831382-0 2021 Effects of memantine and its metabolite Mrz 2/373 on soman-induced inhibition of acetylcholinesterase in vitro. Memantine 11-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 33831382-0 2021 Effects of memantine and its metabolite Mrz 2/373 on soman-induced inhibition of acetylcholinesterase in vitro. Soman 53-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 33831382-2 2021 It also known that memantine pretreatment assured protection of skeletal muscles from poisoning with nerve agents and an interaction between memantine and AChE was proposed. Memantine 19-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 33831382-2 2021 It also known that memantine pretreatment assured protection of skeletal muscles from poisoning with nerve agents and an interaction between memantine and AChE was proposed. Memantine 141-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 33831382-3 2021 In the study presented we examined interactions of memantine and its main metabolite (1-amino-3-hydroxymethyl-5-methyl adamantine, Mrz 2/373) with AChE in vitro as well as their effect on kinetics of the soman-induced AChE inhibition and aging. Memantine 51-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 33831382-3 2021 In the study presented we examined interactions of memantine and its main metabolite (1-amino-3-hydroxymethyl-5-methyl adamantine, Mrz 2/373) with AChE in vitro as well as their effect on kinetics of the soman-induced AChE inhibition and aging. Memantine 51-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 218-222 33831382-3 2021 In the study presented we examined interactions of memantine and its main metabolite (1-amino-3-hydroxymethyl-5-methyl adamantine, Mrz 2/373) with AChE in vitro as well as their effect on kinetics of the soman-induced AChE inhibition and aging. 1-amino-3-hydroxymethyl-5-methyl adamantine 86-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 33831382-3 2021 In the study presented we examined interactions of memantine and its main metabolite (1-amino-3-hydroxymethyl-5-methyl adamantine, Mrz 2/373) with AChE in vitro as well as their effect on kinetics of the soman-induced AChE inhibition and aging. piperidine-1-carboximidamide 131-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 33400519-4 2021 High-throughput screens for the eel AChE inhibitor model identified several molecules including tilorone, an antiviral drug that is well-established outside of the United States, as a newly identified nanomolar AChE inhibitor. Tilorone 96-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 33400519-4 2021 High-throughput screens for the eel AChE inhibitor model identified several molecules including tilorone, an antiviral drug that is well-established outside of the United States, as a newly identified nanomolar AChE inhibitor. Tilorone 96-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-215 33400519-8 2021 This study suggests there may be a potential role for repurposing tilorone or its derivatives in conditions that benefit from AChE inhibition. Tilorone 66-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 33450470-7 2021 HBQ-AE was successfully applied to image nerve agents and AChE activity in living cells. hbq-ae 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 33990679-2 2021 Oxime reactivators of organophosphate (OP)-inhibited acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) serve as antidotes toward poisoning by OPNAs. Oximes 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 33990679-2 2021 Oxime reactivators of organophosphate (OP)-inhibited acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) serve as antidotes toward poisoning by OPNAs. Organophosphates 22-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 33968600-1 2021 In this study, in vitro inhibition effects of (E)-1-(4-aminophenyl)-3-(aryl) prop-2-en-1-one (4-amino-chalcones) derivatives (3a-o) on acetylcholinesterase (AChE) enzyme and human erythrocyte carbonic anhydrase I and II isoenzymes (hCA I- II) were investigated. (e)-1-(4-aminophenyl)-3-(aryl) prop-2-en-1-one (4-amino-chalcones) 46-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 33991570-1 2021 Cholinesterase enzymes such as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) cause hydrolysis of acetylcholine (ACh), a neurotransmitter responsible for the cognitive functions of the brain such as acquiring knowledge and comprehension. Acetylcholine 31-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 33991570-1 2021 Cholinesterase enzymes such as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) cause hydrolysis of acetylcholine (ACh), a neurotransmitter responsible for the cognitive functions of the brain such as acquiring knowledge and comprehension. Acetylcholine 53-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 33991570-3 2021 Herein, we explored the potential inhibitory activities of various pyridine, quinoxaline, and triazine derivatives (3a-k, 6a-j and 11a-h) against AChE and BuChE enzymes by following the modified Ellman"s method. pyridine 67-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 33991570-3 2021 Herein, we explored the potential inhibitory activities of various pyridine, quinoxaline, and triazine derivatives (3a-k, 6a-j and 11a-h) against AChE and BuChE enzymes by following the modified Ellman"s method. Quinoxalines 77-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 33991570-3 2021 Herein, we explored the potential inhibitory activities of various pyridine, quinoxaline, and triazine derivatives (3a-k, 6a-j and 11a-h) against AChE and BuChE enzymes by following the modified Ellman"s method. Triazines 94-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 33960866-10 2022 Five of six patients receiving pralidoxime chloride 2 g showed an initial increase in AChE and BuChE activity that was not sustained despite an infusion of pralidoxime. pralidoxime 31-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 33960866-10 2022 Five of six patients receiving pralidoxime chloride 2 g showed an initial increase in AChE and BuChE activity that was not sustained despite an infusion of pralidoxime. pralidoxime 31-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 33915501-4 2021 The Food and Drug Administration (FDA), has approved acetylcholinesterase (AChE) inhibitors (donepezil, galantamine, tacrine and rivastigmine) and glutamate receptor antagonist (memantine) for the treatment of AD. Donepezil 93-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 33968600-4 2021 Effective inhibitors of carbonic anhydrase I and II isozymes (hCAI and II) and acetylcholinesterase (AChE) enzymes with Ki values in the range of 2.55 +- 0.35-11.75 +- 3.57 nM for hCA I, 4.31 +- 0.78-17.55 +- 5.86 nM for hCA II and 96.01 +- 25.34-1411.41 +- 32.88 nM for AChE, respectively, were the 4-amino-chalcone derivatives (3a-o) molecules. 4-amino-chalcone 300-316 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 33427318-0 2021 Synthesis, characterization, crystal structure, alpha-glycosidase, and acetylcholinesterase inhibitory properties of 1,3-disubstituted benzimidazolium salts. 1,3-disubstituted benzimidazolium salts 117-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 33939580-0 2021 A new flavonoid from the leaves of Garcinia mckeaniana Craib and alpha-glucosidase and acetylcholinesterase inhibitory activities. Flavonoids 6-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 33939580-4 2021 Flavones and biflavones showed are better than flavone glycosides in both alpha-glucosidase and acetylcholinesterase inhibitory activities. Flavones 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 33939580-4 2021 Flavones and biflavones showed are better than flavone glycosides in both alpha-glucosidase and acetylcholinesterase inhibitory activities. biflavones 13-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 33939580-4 2021 Flavones and biflavones showed are better than flavone glycosides in both alpha-glucosidase and acetylcholinesterase inhibitory activities. flavone glycosides 47-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 33715020-0 2021 Physiologically based kinetic modelling based prediction of in vivo rat and human acetylcholinesterase (AChE) inhibition upon exposure to diazinon. Diazinon 138-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 33715020-0 2021 Physiologically based kinetic modelling based prediction of in vivo rat and human acetylcholinesterase (AChE) inhibition upon exposure to diazinon. Diazinon 138-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 33427318-7 2021 AChE converts acetylcholine into choline and acetic acid, thus causing the return of a cholinergic neuron to its resting state. Acetylcholine 14-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 33427318-7 2021 AChE converts acetylcholine into choline and acetic acid, thus causing the return of a cholinergic neuron to its resting state. Choline 20-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 33427318-7 2021 AChE converts acetylcholine into choline and acetic acid, thus causing the return of a cholinergic neuron to its resting state. Acetic Acid 45-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 33502038-0 2021 Synthesis of N-alkylated pyrazolo[3,4-d]pyrimidine analogs and evaluation of acetylcholinesterase and carbonic anhydrase inhibition properties. n-alkylated pyrazolo[3,4-d]pyrimidine 13-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 33934188-0 2021 Ensemble machine learning to evaluate the in vivo acute oral toxicity and in vitro human acetylcholinesterase inhibitory activity of organophosphates. Organophosphates 133-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 33629750-1 2021 Carbofuran is a broad-spectrum carbamate insecticide, which principally inhibits the acetylcholinesterase (AChE) enzyme in the nervous system. Carbofuran 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 33629750-1 2021 Carbofuran is a broad-spectrum carbamate insecticide, which principally inhibits the acetylcholinesterase (AChE) enzyme in the nervous system. Carbofuran 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 33629750-1 2021 Carbofuran is a broad-spectrum carbamate insecticide, which principally inhibits the acetylcholinesterase (AChE) enzyme in the nervous system. Carbamates 31-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 33629750-1 2021 Carbofuran is a broad-spectrum carbamate insecticide, which principally inhibits the acetylcholinesterase (AChE) enzyme in the nervous system. Carbamates 31-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 32124162-0 2021 Design, synthesis and evaluation of new chromone-derived aminophosphonates as potential acetylcholinesterase inhibitor. chromone-derived aminophosphonates 40-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 33930191-0 2021 Promising tacrine/huperzine A- based dimeric AChE inhibitors for neurodegenerative disorders: from relieving symptoms to modifying diseases through multi-target. Tacrine 10-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 33930191-0 2021 Promising tacrine/huperzine A- based dimeric AChE inhibitors for neurodegenerative disorders: from relieving symptoms to modifying diseases through multi-target. huperzine A 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 33946559-5 2021 Indirubin and dehydroevodiamine were the best potential AChE inhibitors with free binding energies of -10.03 and -9.00 kcal/mol, respectively. dehydroevodiamine 14-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 33946559-7 2021 Six H-bonds were involved in the "indirubin-AChE" interaction and three H-bonds in the "dehydroevodiamine-AChE" interaction. indirubin 34-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 33946559-7 2021 Six H-bonds were involved in the "indirubin-AChE" interaction and three H-bonds in the "dehydroevodiamine-AChE" interaction. dehydroevodiamine 88-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 33946559-9 2021 Furthermore, "indirubin-AChE" and "dehydroevodiamine-AChE" complexes were found to be stable, as determined by root mean square deviation (RMSD) during a 50 ns molecular dynamics simulation study. indirubin 14-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 33946559-9 2021 Furthermore, "indirubin-AChE" and "dehydroevodiamine-AChE" complexes were found to be stable, as determined by root mean square deviation (RMSD) during a 50 ns molecular dynamics simulation study. dehydroevodiamine 35-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 33946559-5 2021 Indirubin and dehydroevodiamine were the best potential AChE inhibitors with free binding energies of -10.03 and -9.00 kcal/mol, respectively. indirubin 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 33914192-5 2021 The spider mite E316, H369, and V105 active sites are important for AChE function. BOC-PYR-OH 22-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 33922645-8 2021 Moreover, ethanol extract of kinkor (Ferulago stellata) demonstrated IC50 values of 1.772 mug/mL against acetylcholinesterase (AChE), 33.56 +- 2.96 mug/mL against alpha-glycosidase, and 0.639 mug/mL against alpha-amylase enzyme respectively. Ethanol 10-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 33922645-8 2021 Moreover, ethanol extract of kinkor (Ferulago stellata) demonstrated IC50 values of 1.772 mug/mL against acetylcholinesterase (AChE), 33.56 +- 2.96 mug/mL against alpha-glycosidase, and 0.639 mug/mL against alpha-amylase enzyme respectively. Ethanol 10-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 33922328-0 2021 In Vitro Enzymatic and Kinetic Studies, and In Silico Drug-Receptor Interactions, and Drug-Like Profiling of the 5-Styrylbenzamide Derivatives as Potential Cholinesterase and beta-Secretase Inhibitors with Antioxidant Properties. 5-styrylbenzamide 113-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-170 33922328-2 2021 These 5-styrylbenzamide derivatives were evaluated through enzymatic assays in vitro for their capability to inhibit acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and beta-secretase (BACE-1) activities as well as for antioxidant potential. 5-styrylbenzamide 6-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 33922328-2 2021 These 5-styrylbenzamide derivatives were evaluated through enzymatic assays in vitro for their capability to inhibit acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and beta-secretase (BACE-1) activities as well as for antioxidant potential. 5-styrylbenzamide 6-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 32124162-1 2021 A series of novel N-substituted alpha-aminophosphonates-bearing chromone moiety were synthesized and evaluated for acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) activities and antioxidant properties. n-substituted alpha-aminophosphonates 18-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 32124162-1 2021 A series of novel N-substituted alpha-aminophosphonates-bearing chromone moiety were synthesized and evaluated for acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) activities and antioxidant properties. n-substituted alpha-aminophosphonates 18-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 32124162-4 2021 The results show that among the various synthesized compounds, strongest AChE inhibition was found for the compound containing aliphatic amine analogs, while in case of BuChE, aromatic amines showed better activity as compared to aliphatic amines. diethanolamine 127-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 33921560-2 2021 Here, the plain and hydrophilic-modified poly(epsilon-caprolactone) (PCL) fiber mats were used for the absorption of indolyl acetate and acetylcholinesterase (AChE), respectively. polycaprolactone 41-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 33921560-2 2021 Here, the plain and hydrophilic-modified poly(epsilon-caprolactone) (PCL) fiber mats were used for the absorption of indolyl acetate and acetylcholinesterase (AChE), respectively. polycaprolactone 41-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 33889183-2 2021 The enzyme AChE provokes the hydrolysis of substrate acetylcholine (ACh) in the nervous system and terminates nerve impulse. Acetylcholine 53-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-15 33872422-1 2021 Inspired by the structures of donepezil and rivastigmine, a novel series of indanone-carbamate hybrids was synthesized using the pharmacophore hybridization-based design strategy, and their biological activities toward acetylcholinesterase (AChE) and butyrylcholinesterase were evaluated. indacrinone 76-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 219-239 33872422-1 2021 Inspired by the structures of donepezil and rivastigmine, a novel series of indanone-carbamate hybrids was synthesized using the pharmacophore hybridization-based design strategy, and their biological activities toward acetylcholinesterase (AChE) and butyrylcholinesterase were evaluated. indacrinone 76-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 241-245 33872422-1 2021 Inspired by the structures of donepezil and rivastigmine, a novel series of indanone-carbamate hybrids was synthesized using the pharmacophore hybridization-based design strategy, and their biological activities toward acetylcholinesterase (AChE) and butyrylcholinesterase were evaluated. Carbamates 85-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 219-239 33872422-1 2021 Inspired by the structures of donepezil and rivastigmine, a novel series of indanone-carbamate hybrids was synthesized using the pharmacophore hybridization-based design strategy, and their biological activities toward acetylcholinesterase (AChE) and butyrylcholinesterase were evaluated. Carbamates 85-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 241-245 33919582-6 2021 Importantly, with an increase in solubility and permeability of piperine as a result of interaction with CD, it was proven to maintain its biological activity concerning the antioxidant potential (2,2-diphenyl-1-picryl-hydrazyl-hydrate assay), inhibition of enzymes essential for the inflammatory process and for neurodegenerative changes (hyaluronidase, acetylcholinesterase, butyrylcholinesterase). piperine 64-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 355-375 33919582-6 2021 Importantly, with an increase in solubility and permeability of piperine as a result of interaction with CD, it was proven to maintain its biological activity concerning the antioxidant potential (2,2-diphenyl-1-picryl-hydrazyl-hydrate assay), inhibition of enzymes essential for the inflammatory process and for neurodegenerative changes (hyaluronidase, acetylcholinesterase, butyrylcholinesterase). Cadmium 105-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 355-375 33923726-0 2021 Chromeno[3,4-b]xanthones as First-in-Class AChE and Abeta Aggregation Dual-Inhibitors. chromeno[3,4-b]xanthones 0-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 33923726-4 2021 Following this concept, herein we describe the design, synthesis, and biological evaluation of a family of chromeno[3,4-b]xanthones as well as their (E)-2-[2-(propargyloxy)styryl]chromone precursors, as first-in-class acetylcholinesterase (AChE) and beta-amyloid (Abeta) aggregation dual-inhibitors. chromeno[3,4-b]xanthones 107-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 218-238 33923726-4 2021 Following this concept, herein we describe the design, synthesis, and biological evaluation of a family of chromeno[3,4-b]xanthones as well as their (E)-2-[2-(propargyloxy)styryl]chromone precursors, as first-in-class acetylcholinesterase (AChE) and beta-amyloid (Abeta) aggregation dual-inhibitors. chromeno[3,4-b]xanthones 107-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 240-244 33923726-4 2021 Following this concept, herein we describe the design, synthesis, and biological evaluation of a family of chromeno[3,4-b]xanthones as well as their (E)-2-[2-(propargyloxy)styryl]chromone precursors, as first-in-class acetylcholinesterase (AChE) and beta-amyloid (Abeta) aggregation dual-inhibitors. e)-2-[2-(propargyloxy)styryl]chromone 150-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 218-238 33923726-6 2021 The molecular docking showed that most of the compounds bound to AChE through hydrogen bonds with residues of the catalytic triad and pi-stacking interactions between the main scaffold and the aromatic residues present in the binding pocket. Hydrogen 78-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 33860917-9 2021 The positive effects of daphnetin have been also related to its AChE, BChE, and BACE-1 inhibitory potential. daphnetin 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 33936095-3 2021 The cholinergic system includes the neurotransmitter\ molecule, acetylcholine (ACh), cholinergic receptors (AChRs), choline acetyltransferase (ChAT) enzyme, and acetylcholinesterase (AChE) enzyme. Choline 4-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-187 33839958-0 2021 Colorimetric detection of acetylcholinesterase and its inhibitor based on thiol-regulated oxidase-like activity of 2D palladium square nanoplates on reduced graphene oxide. Sulfhydryl Compounds 74-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 33839958-0 2021 Colorimetric detection of acetylcholinesterase and its inhibitor based on thiol-regulated oxidase-like activity of 2D palladium square nanoplates on reduced graphene oxide. Palladium 118-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 33839958-0 2021 Colorimetric detection of acetylcholinesterase and its inhibitor based on thiol-regulated oxidase-like activity of 2D palladium square nanoplates on reduced graphene oxide. graphene oxide 157-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 33839958-1 2021 A convenient and sensitive colorimetric assay for acetylcholinesterase (AChE) and its inhibitor has been designed based on the oxidase-like activity of {100}-faceted Pd square nanoplates which are grown in situ on reduced graphene oxide (PdSP@rGO). Palladium 166-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 33839958-1 2021 A convenient and sensitive colorimetric assay for acetylcholinesterase (AChE) and its inhibitor has been designed based on the oxidase-like activity of {100}-faceted Pd square nanoplates which are grown in situ on reduced graphene oxide (PdSP@rGO). Palladium 166-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 33839958-1 2021 A convenient and sensitive colorimetric assay for acetylcholinesterase (AChE) and its inhibitor has been designed based on the oxidase-like activity of {100}-faceted Pd square nanoplates which are grown in situ on reduced graphene oxide (PdSP@rGO). graphene oxide 222-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 33839958-1 2021 A convenient and sensitive colorimetric assay for acetylcholinesterase (AChE) and its inhibitor has been designed based on the oxidase-like activity of {100}-faceted Pd square nanoplates which are grown in situ on reduced graphene oxide (PdSP@rGO). graphene oxide 222-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 33839958-3 2021 In the presence of AChE, acetylthiocholine (ATCh), a typical AChE substrate, is hydrolyzed to thiocholine (TCh). Acetylthiocholine 25-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 33839958-3 2021 In the presence of AChE, acetylthiocholine (ATCh), a typical AChE substrate, is hydrolyzed to thiocholine (TCh). Acetylthiocholine 25-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 33839958-3 2021 In the presence of AChE, acetylthiocholine (ATCh), a typical AChE substrate, is hydrolyzed to thiocholine (TCh). Acetylthiocholine 44-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 33839958-3 2021 In the presence of AChE, acetylthiocholine (ATCh), a typical AChE substrate, is hydrolyzed to thiocholine (TCh). Acetylthiocholine 44-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 33839958-3 2021 In the presence of AChE, acetylthiocholine (ATCh), a typical AChE substrate, is hydrolyzed to thiocholine (TCh). Thiocholine 31-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 33839958-3 2021 In the presence of AChE, acetylthiocholine (ATCh), a typical AChE substrate, is hydrolyzed to thiocholine (TCh). Thiocholine 31-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 33839958-3 2021 In the presence of AChE, acetylthiocholine (ATCh), a typical AChE substrate, is hydrolyzed to thiocholine (TCh). Thiocholine 45-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 33839958-3 2021 In the presence of AChE, acetylthiocholine (ATCh), a typical AChE substrate, is hydrolyzed to thiocholine (TCh). Thiocholine 45-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 33839958-6 2021 Furthermore, because of the inhibition effect of tacrine on AChE, tacrine is also detected through the colorimetric AChE assay system within the concentrations range 0.025-0.4 muM with a LOD of 0.00229 muM. Tacrine 49-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 33839958-6 2021 Furthermore, because of the inhibition effect of tacrine on AChE, tacrine is also detected through the colorimetric AChE assay system within the concentrations range 0.025-0.4 muM with a LOD of 0.00229 muM. Tacrine 66-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 33839958-6 2021 Furthermore, because of the inhibition effect of tacrine on AChE, tacrine is also detected through the colorimetric AChE assay system within the concentrations range 0.025-0.4 muM with a LOD of 0.00229 muM. Tacrine 66-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 33839958-8 2021 Colorimetric method for detection of AChE and its inhibitor is established by modulating the oxidase mimetic activity of {100}-faceted Pd square nanoplates on reduced graphene oxide (PdSP@rGO). Palladium 135-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 33839958-8 2021 Colorimetric method for detection of AChE and its inhibitor is established by modulating the oxidase mimetic activity of {100}-faceted Pd square nanoplates on reduced graphene oxide (PdSP@rGO). graphene oxide 167-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 33839958-8 2021 Colorimetric method for detection of AChE and its inhibitor is established by modulating the oxidase mimetic activity of {100}-faceted Pd square nanoplates on reduced graphene oxide (PdSP@rGO). pdsp 183-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 33889183-4 2021 Methods: The present study was designed to evaluate the effect of palladium(II) complex as antivenom against krait venom AChE using kinetics methods. palladium(ii) 66-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 33889183-5 2021 Results: Statistical analysis showed that krait venom AChE inhibition decreases with the increase of Pd(II) complex (0.025-0.05 microM) and exerted 61% inhibition against the AChE at a fixed concentration (0.5 mM) of ACh. poly-4-dioxan-2-one 101-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 33889183-5 2021 Results: Statistical analysis showed that krait venom AChE inhibition decreases with the increase of Pd(II) complex (0.025-0.05 microM) and exerted 61% inhibition against the AChE at a fixed concentration (0.5 mM) of ACh. Acetylcholine 54-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 175-179 33889183-8 2021 It was observed that K m (Michaelis-Menten constant of AChE-ACh into AChE and product) increased from 0.108 to 0.310 mM (45.74 to 318.35%) and V max remained constant with an increase of Pd(II) complex concentrations. Acetylcholine 55-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 33889183-8 2021 It was observed that K m (Michaelis-Menten constant of AChE-ACh into AChE and product) increased from 0.108 to 0.310 mM (45.74 to 318.35%) and V max remained constant with an increase of Pd(II) complex concentrations. poly-4-dioxan-2-one 187-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 33889183-8 2021 It was observed that K m (Michaelis-Menten constant of AChE-ACh into AChE and product) increased from 0.108 to 0.310 mM (45.74 to 318.35%) and V max remained constant with an increase of Pd(II) complex concentrations. poly-4-dioxan-2-one 187-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 33889183-12 2021 Conclusions: The results show that the Pd(II) complex can be deliberated as an inhibitor of AChE. poly-4-dioxan-2-one 39-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 33869871-0 2021 Design, synthesis and biological assessment of new 1-benzyl-4-((4-oxoquinazolin-3(4H)-yl)methyl) pyridin-1-ium derivatives (BOPs) as potential dual inhibitors of acetylcholinesterase and butyrylcholinesterase. 1-benzyl-4-((4-oxoquinazolin-3(4h)-yl)methyl) pyridin-1-ium derivatives 51-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-182 33869871-0 2021 Design, synthesis and biological assessment of new 1-benzyl-4-((4-oxoquinazolin-3(4H)-yl)methyl) pyridin-1-ium derivatives (BOPs) as potential dual inhibitors of acetylcholinesterase and butyrylcholinesterase. bops 124-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-182 33869871-3 2021 In this study, we would like to report the design and synthesis of a new sequence of 1-benzyl-4-((4-oxoquinazolin-3(4H)-yl)methyl) pyridin-1-ium derivatives (BOPs) assessed as BuChE and AChE inhibitors. 1-benzyl-4-((4-oxoquinazolin-3(4h)-yl)methyl) pyridin-1-ium derivatives 85-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 33869871-3 2021 In this study, we would like to report the design and synthesis of a new sequence of 1-benzyl-4-((4-oxoquinazolin-3(4H)-yl)methyl) pyridin-1-ium derivatives (BOPs) assessed as BuChE and AChE inhibitors. bops 158-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 33652925-5 2021 Both isolated alkaloids were screened for their human acetylcholinesterase (hAChE) and butyrylcholinesterase (hBuChE) inhibition activity. Alkaloids 14-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-81 33917200-2 2021 Biscoumarin 12d was found to be the most effective inhibitor of both acetylcholinesterase (AChE, IC50 = 6.30 microM) and butyrylcholinesterase (BChE, IC50 = 49 microM). biscoumarin 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 33917200-2 2021 Biscoumarin 12d was found to be the most effective inhibitor of both acetylcholinesterase (AChE, IC50 = 6.30 microM) and butyrylcholinesterase (BChE, IC50 = 49 microM). biscoumarin 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 33582578-9 2021 Respective compounds BS-10 and BS-22 inhibited AChE-induced Abeta1-42 aggregation in thioflavin T-assay at 10 muM and 20 muM, but BS-10 at 10 muM and 20 muM concentrations are found more potent than BS-22. thioflavin T 85-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 33582578-13 2021 Hence, the novel phenylsulfonyl-pyrimidine carboxylate derivatives can act as promising leads in the development of AChE inhibitors and Abeta disaggregator for the treatment of AD. phenylsulfonyl-pyrimidine carboxylate 17-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 33869976-3 2021 Among them, N-(4-(trifluoromethyl)phenyl)-tacrine (3g) and N-(4-methoxypyridin-2-yl)-tacrine (3o) showed the most potent activity against AChE (IC50 values of 1.77 and 1.48 muM, respectively). n-(4-(trifluoromethyl)phenyl)-tacrine 12-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 33869976-3 2021 Among them, N-(4-(trifluoromethyl)phenyl)-tacrine (3g) and N-(4-methoxypyridin-2-yl)-tacrine (3o) showed the most potent activity against AChE (IC50 values of 1.77 and 1.48 muM, respectively). n-(4-methoxypyridin-2-yl)-tacrine 59-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 33869976-3 2021 Among them, N-(4-(trifluoromethyl)phenyl)-tacrine (3g) and N-(4-methoxypyridin-2-yl)-tacrine (3o) showed the most potent activity against AChE (IC50 values of 1.77 and 1.48 muM, respectively). 3o 94-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 33538594-0 2021 Structural and Biochemical Insights into the Inhibition of Human Acetylcholinesterase by G-Series Nerve Agents and Subsequent Reactivation by HI-6. asoxime chloride 142-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 33538594-5 2021 To gain insight into this issue, the structures of hAChE inhibited by tabun, sarin, cyclosarin, soman, and GP were obtained along with the inhibition kinetics for these agents. tabun 70-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-56 33538594-5 2021 To gain insight into this issue, the structures of hAChE inhibited by tabun, sarin, cyclosarin, soman, and GP were obtained along with the inhibition kinetics for these agents. Sarin 77-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-56 33538594-7 2021 With reports indicating that the efficacy of reactivators can vary based on the nerve agent inhibiting hAChE, human recombinatorially expressed hAChE was utilized to define these variations for HI-6 among various G-agents. asoxime chloride 194-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-149 33538594-8 2021 To identify the structural underpinnings of this phenomenon, the structures of tabun, sarin, and soman-inhibited hAChE in complex with HI-6 were determined. tabun 79-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-118 33538594-8 2021 To identify the structural underpinnings of this phenomenon, the structures of tabun, sarin, and soman-inhibited hAChE in complex with HI-6 were determined. Soman 97-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-118 33538594-8 2021 To identify the structural underpinnings of this phenomenon, the structures of tabun, sarin, and soman-inhibited hAChE in complex with HI-6 were determined. asoxime chloride 135-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-118 33660328-2 2022 Graphene (Gra) nano-fragments modified with chitosan and acetylcholinesterase were successively drip-coated on the surface of a glassy carbon electrode via a layer-by-layer assembly method. Graphite 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 33660328-2 2022 Graphene (Gra) nano-fragments modified with chitosan and acetylcholinesterase were successively drip-coated on the surface of a glassy carbon electrode via a layer-by-layer assembly method. Graphite 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 32458455-1 2021 This research work examined and likened effect of eugenol a natural phenolic compound with butylated hydroxylanisole (BHA) and butylated hydroxyl toluene (BHT) synthetic phenolic compounds with key biomolecules [acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and monoamine oxidase (MAO)] relevant to Alzheimer"s diseases (AD) in vitro. Eugenol 50-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 234-238 32458455-4 2021 The results revealed eugenol, BHT, and BHA inhibited AChE, BChE, and MAO activities dose-dependently. Eugenol 21-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 32458455-4 2021 The results revealed eugenol, BHT, and BHA inhibited AChE, BChE, and MAO activities dose-dependently. Butylated Hydroxytoluene 30-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 32720328-10 2021 Similarly, the ethanol extract (IC50 = 13.83 microg/ml) exhibited the highest acetylcholinesterase inhibitory activity, while the dichloromethane extract showed the highest butyrylcholinesterase inhibitory activity. Ethanol 15-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 32720328-11 2021 All the extracts exhibited antioxidant properties and inhibitory effects against butyrylcholinesterase and acetylcholinesterase; however, ethanol extracts showed better activity. Ethanol 138-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 33230575-1 2021 Acetylcholinesterase inhibitors such as donepezil delay the progression of Alzheimer"s dementia by increasing acetylcholine concentrations in the central nervous system. Donepezil 40-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 33230575-1 2021 Acetylcholinesterase inhibitors such as donepezil delay the progression of Alzheimer"s dementia by increasing acetylcholine concentrations in the central nervous system. Acetylcholine 110-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 33379009-0 2021 Dual electrophoretically-mediated microanalysis in multiple injection mode for the simultaneous determination of acetylcholinesterase and alpha-glucosidase activity applied to selected polyphenols. Polyphenols 185-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-133 33379009-6 2021 Ki values were 4.27 mumol L-1 for neostigmine (an AChE inhibitor) and 0.40 mmol L-1 for acarbose (an alpha-glu inhibitor). Neostigmine 34-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 33379009-10 2021 The method was applied to evaluate 10 phenolic compounds, of wich p-coumaric acid showed the best inhibitory activity for AChE (40.14 +- 4.75% at 10 mg L-1); and quercetin for alpha-glu (46.53 +- 4.90% at 10 mg L-1). Coumaric Acids 68-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 33916760-8 2021 It was found that the selected compound was a powerful non-toxic AChE inhibitor, 68 times more active than GAL, and could serve as a lead molecule for further optimization and development. Galantamine 107-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 33916863-0 2021 A Fluidics-Based Biosensor to Detect and Characterize Inhibition Patterns of Organophosphate to Acetylcholinesterase in Food Materials. Organophosphates 77-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 33916863-2 2021 The principle of the sensing platform is based on the inhibition of dimethoate (DMT), a typical OP that specifically inhibits acetylcholinesterase (AChE) activity. Dimethoate 68-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 33916863-2 2021 The principle of the sensing platform is based on the inhibition of dimethoate (DMT), a typical OP that specifically inhibits acetylcholinesterase (AChE) activity. Dimethoate 68-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 33916863-2 2021 The principle of the sensing platform is based on the inhibition of dimethoate (DMT), a typical OP that specifically inhibits acetylcholinesterase (AChE) activity. Dimethoate 80-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 33916863-2 2021 The principle of the sensing platform is based on the inhibition of dimethoate (DMT), a typical OP that specifically inhibits acetylcholinesterase (AChE) activity. Dimethoate 80-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 33916863-5 2021 The total amount of AChE was quantified, whose activity inhibition was highly linear with respect to DMT concentration. Dimethoate 101-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 31583530-2 2021 Acetylcholinesterase inhibitors (AChEI), the symptomatic therapy in AD, attenuate and delay the cognitive deficit by enhancing cholinergic synapses. Acetylcholine 33-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 31135232-0 2021 Investigation of the toxicological and inhibitory effects of some benzimidazole agents on acetylcholinesterase and butyrylcholinesterase enzymes. benzimidazole 66-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 31135232-2 2021 In this work, I investigated the effect of drugs such as ricobendazole, thiabendazole, albendazole, and oxfendazole, on Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE) enzyme activity. albendazole sulfoxide 57-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 31135232-2 2021 In this work, I investigated the effect of drugs such as ricobendazole, thiabendazole, albendazole, and oxfendazole, on Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE) enzyme activity. albendazole sulfoxide 57-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 31135232-2 2021 In this work, I investigated the effect of drugs such as ricobendazole, thiabendazole, albendazole, and oxfendazole, on Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE) enzyme activity. Thiabendazole 72-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 31135232-2 2021 In this work, I investigated the effect of drugs such as ricobendazole, thiabendazole, albendazole, and oxfendazole, on Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE) enzyme activity. Thiabendazole 72-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 31135232-2 2021 In this work, I investigated the effect of drugs such as ricobendazole, thiabendazole, albendazole, and oxfendazole, on Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE) enzyme activity. Albendazole 87-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 31135232-2 2021 In this work, I investigated the effect of drugs such as ricobendazole, thiabendazole, albendazole, and oxfendazole, on Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE) enzyme activity. Albendazole 87-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 31135232-2 2021 In this work, I investigated the effect of drugs such as ricobendazole, thiabendazole, albendazole, and oxfendazole, on Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE) enzyme activity. oxfendazole 104-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 31135232-2 2021 In this work, I investigated the effect of drugs such as ricobendazole, thiabendazole, albendazole, and oxfendazole, on Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE) enzyme activity. oxfendazole 104-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 31135232-4 2021 Study findings have shown that benzimidazoles inhibit both AChE and BChE enzymes at the nanomolar level. Benzimidazoles 31-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 31135232-5 2021 The compound that best was inhibited the AChE enzyme ricobendazole, and it was that the best inhibited the BChE enzyme thiabendazole. albendazole sulfoxide 53-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 31135232-5 2021 The compound that best was inhibited the AChE enzyme ricobendazole, and it was that the best inhibited the BChE enzyme thiabendazole. Thiabendazole 119-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 31172840-1 2021 In this study, we report the synthesis of novel tris-chalcones and testing of human carbonic anhydrase I, and II isoenzymes (hCA I, and hCA II), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and alpha-glycosidase (alpha-Gly) inhibitors for the development of novel chalcone structures towards for treatment of some diseases. tris-chalcones 48-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 31172840-3 2021 The results revealed that novel tris-chalcones can have promising drug potential for glaucoma, leukaemia, epilepsy; Alzheimer"s disease that was associated with the high enzymatic activity of hCA I, hCA II, AChE, and BChE enzymes. tris-chalcones 32-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-211 33283898-0 2021 Synthesis and in vitro carbonic anhydrases and acetylcholinesterase inhibitory activities of novel imidazolinone-based benzenesulfonamides. 4-imidazolone 99-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 33283898-0 2021 Synthesis and in vitro carbonic anhydrases and acetylcholinesterase inhibitory activities of novel imidazolinone-based benzenesulfonamides. benzenesulfonamide 119-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 33283898-7 2021 Compounds 3c and 4c, where the sulfanilamide moiety is available, were the leads in terms of AChE inhibition with the lowest Ki values. Sulfanilamide 31-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 33300644-1 2021 A new class of cyanopyridine derivatives (10a-e and 11a-e) containing the phenylurea unit was synthesized and tested against some metabolic enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and alpha-glycosidase (alpha-Gly). 2-Cyanopyridine 15-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-178 33300644-1 2021 A new class of cyanopyridine derivatives (10a-e and 11a-e) containing the phenylurea unit was synthesized and tested against some metabolic enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and alpha-glycosidase (alpha-Gly). 2-Cyanopyridine 15-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 33300644-2 2021 The new cyanopyridine derivatives showed Ki values in the range of 40.73 +- 6.54 to 87.05 +- 16.98 microM against AChE, 29.17 +- 4.88 to 124.03 +- 22.43 microM against BChE, and 3.66 +- 0.93 to 26.33 +- 5.05 microM against alpha-Gly. 2-Cyanopyridine 8-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 33300644-2 2021 The new cyanopyridine derivatives showed Ki values in the range of 40.73 +- 6.54 to 87.05 +- 16.98 microM against AChE, 29.17 +- 4.88 to 124.03 +- 22.43 microM against BChE, and 3.66 +- 0.93 to 26.33 +- 5.05 microM against alpha-Gly. alpha-gly 223-232 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 33528765-7 2021 Enzyme inhibitions of the metal complexes were investigated against glutathione S-transferase (GST), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzymes. Metals 26-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 33528765-7 2021 Enzyme inhibitions of the metal complexes were investigated against glutathione S-transferase (GST), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzymes. Metals 26-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 33528765-9 2021 Also, the Pd(II) complex showed the best inhibition value (10.17 +- 1.88 microM) against AChE. poly-4-dioxan-2-one 10-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 33571502-3 2021 Motivated by currently available treatment against neurodegenerative diseases involving the inhibitors of acetylcholinesterase (AChE) and NMDARs, administered also in combination, we developed a dually-acting compound 7-phenoxytacrine (7-PhO-THA) and evaluated its neuropsychopharmacological and drug-like properties for potential therapeutic use. 7-phenoxytacrine 218-234 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 33571502-3 2021 Motivated by currently available treatment against neurodegenerative diseases involving the inhibitors of acetylcholinesterase (AChE) and NMDARs, administered also in combination, we developed a dually-acting compound 7-phenoxytacrine (7-PhO-THA) and evaluated its neuropsychopharmacological and drug-like properties for potential therapeutic use. 7-phenoxytacrine 218-234 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 33571502-4 2021 Indeed, we have confirmed the dual potency of 7-PhO-THA, i.e. potent and balanced inhibition of both AChE and NMDARs. 7-pho-tha 46-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 33485672-1 2021 Organophosphorus pesticides (OPs) interfere with the activity of acetylcholinesterase (AChE), a vital enzyme that regulates the functioning of the nervous system, resulting in acetylcholine (Ach) accumulation at the synapses and myoneural junctions. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 33485672-1 2021 Organophosphorus pesticides (OPs) interfere with the activity of acetylcholinesterase (AChE), a vital enzyme that regulates the functioning of the nervous system, resulting in acetylcholine (Ach) accumulation at the synapses and myoneural junctions. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 33485672-1 2021 Organophosphorus pesticides (OPs) interfere with the activity of acetylcholinesterase (AChE), a vital enzyme that regulates the functioning of the nervous system, resulting in acetylcholine (Ach) accumulation at the synapses and myoneural junctions. Acetylcholine 65-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 33485672-1 2021 Organophosphorus pesticides (OPs) interfere with the activity of acetylcholinesterase (AChE), a vital enzyme that regulates the functioning of the nervous system, resulting in acetylcholine (Ach) accumulation at the synapses and myoneural junctions. Acetylcholine 191-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 33485672-1 2021 Organophosphorus pesticides (OPs) interfere with the activity of acetylcholinesterase (AChE), a vital enzyme that regulates the functioning of the nervous system, resulting in acetylcholine (Ach) accumulation at the synapses and myoneural junctions. Acetylcholine 191-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 33620128-2 2021 In vitro and in silico inhibitory effects of the novel ureido-substituted sulfaguanidine derivatives were investigated by spectrophotometric methods for alpha-glycosidase (alpha-GLY), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzymes associated with diabetes mellitus (DM) and Alzheimer"s disease (AD). ureido-substituted sulfaguanidine 55-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 206-210 33529929-4 2021 On the other hand, AChE can catalyze the hydrolysis of Myr into choline and myristic acid. myr 55-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 33529929-4 2021 On the other hand, AChE can catalyze the hydrolysis of Myr into choline and myristic acid. Choline 64-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 33529929-4 2021 On the other hand, AChE can catalyze the hydrolysis of Myr into choline and myristic acid. Myristic Acid 76-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 33529929-6 2021 However, in the presence of AChE-inhibiting pesticides, such as fenobucarb and malathion, the activity of AChE is inhibited, and thus, the enzymatic hydrolysis of Myr cannot occur. BPMC 64-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 33529929-6 2021 However, in the presence of AChE-inhibiting pesticides, such as fenobucarb and malathion, the activity of AChE is inhibited, and thus, the enzymatic hydrolysis of Myr cannot occur. BPMC 64-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 33529929-6 2021 However, in the presence of AChE-inhibiting pesticides, such as fenobucarb and malathion, the activity of AChE is inhibited, and thus, the enzymatic hydrolysis of Myr cannot occur. Malathion 79-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 33529929-6 2021 However, in the presence of AChE-inhibiting pesticides, such as fenobucarb and malathion, the activity of AChE is inhibited, and thus, the enzymatic hydrolysis of Myr cannot occur. Malathion 79-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 33844597-1 2021 BACKGROUND: Inhibition of acetylcholinesterase (AChE), a biomarker of organophosphorous and carbamate exposure in environmental and occupational human health, has been commonly used to identify potential safety liabilities. organophosphorous 70-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 33844597-1 2021 BACKGROUND: Inhibition of acetylcholinesterase (AChE), a biomarker of organophosphorous and carbamate exposure in environmental and occupational human health, has been commonly used to identify potential safety liabilities. organophosphorous 70-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 33844597-1 2021 BACKGROUND: Inhibition of acetylcholinesterase (AChE), a biomarker of organophosphorous and carbamate exposure in environmental and occupational human health, has been commonly used to identify potential safety liabilities. Carbamates 92-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 33844597-1 2021 BACKGROUND: Inhibition of acetylcholinesterase (AChE), a biomarker of organophosphorous and carbamate exposure in environmental and occupational human health, has been commonly used to identify potential safety liabilities. Carbamates 92-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 33844597-3 2021 AChE inhibitors can have therapeutic applications (e.g., tacrine and donepezil) or neurotoxic consequences (e.g., insecticides and nerve agents). Tacrine 57-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 33844597-3 2021 AChE inhibitors can have therapeutic applications (e.g., tacrine and donepezil) or neurotoxic consequences (e.g., insecticides and nerve agents). Donepezil 69-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 33844597-8 2021 RESULTS: A group of known AChE inhibitors, such as donepezil, ambenonium dichloride, and tacrine hydrochloride, as well as many previously unreported AChE inhibitors, such as chelerythrine chloride and cilostazol, were identified in this study. chelerythrine 175-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 33581413-0 2021 Acetylcholinesterase activity and thyroid hormone levels in Ecuadorian adolescents living in agricultural settings where organophosphate pesticides are used. Organophosphates 121-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 33581413-1 2021 BACKGROUND: Organophosphates are frequently applied insecticides that inhibit acetylcholinesterase (AChE) activity resulting in cholinergic overstimulation. Organophosphates 12-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 33581413-1 2021 BACKGROUND: Organophosphates are frequently applied insecticides that inhibit acetylcholinesterase (AChE) activity resulting in cholinergic overstimulation. Organophosphates 12-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 33581413-3 2021 We aimed to test the associations between AChE activity, a physiological marker of organophosphate exposure, and thyroid function in adolescents. Organophosphates 83-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 33581413-9 2021 Lower AChE activity, indicating greater organophosphate exposure, was marginally associated with greater fT4 concentrations (difference per SD decrease in AChE activity (beta) = 0.03 ng/dL, [90% CI: 0.00, 0.06]) but not with TSH (beta = -0.01 muIU/ml, [-0.38, 0.36]). Organophosphates 40-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 33581413-9 2021 Lower AChE activity, indicating greater organophosphate exposure, was marginally associated with greater fT4 concentrations (difference per SD decrease in AChE activity (beta) = 0.03 ng/dL, [90% CI: 0.00, 0.06]) but not with TSH (beta = -0.01 muIU/ml, [-0.38, 0.36]). CHEMBL179036 105-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 33581413-11 2021 In girls, lower AChE activity was associated with higher fT4 levels (beta=0.05 ng/dL [0.01, 0.10]) and lower TSH concentrations (beta = -0.51 muIU/ml, [-1.00, -0.023]). CHEMBL179036 57-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 33581413-11 2021 In girls, lower AChE activity was associated with higher fT4 levels (beta=0.05 ng/dL [0.01, 0.10]) and lower TSH concentrations (beta = -0.51 muIU/ml, [-1.00, -0.023]). Thyrotropin 109-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 32266865-2 2021 In this study, twenty-nine novel 3-aryl-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives were synthesized and assayed for their human acetylcholinesterase (hAChE) inhibitory activities. 3-aryl-7h-thiazolo[3,2-b]-1,2,4-triazin-7-one 33-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-163 34012694-4 2021 Acetylthiocholine (ATCh) could be catalytically hydrolyzed by acetylcholinesterase (AChE) to form thiocholine, which induces aggregation of the AgNPs. Acetylthiocholine 0-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 34012694-4 2021 Acetylthiocholine (ATCh) could be catalytically hydrolyzed by acetylcholinesterase (AChE) to form thiocholine, which induces aggregation of the AgNPs. Acetylthiocholine 0-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 34012694-4 2021 Acetylthiocholine (ATCh) could be catalytically hydrolyzed by acetylcholinesterase (AChE) to form thiocholine, which induces aggregation of the AgNPs. Thiocholine 6-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 34012694-4 2021 Acetylthiocholine (ATCh) could be catalytically hydrolyzed by acetylcholinesterase (AChE) to form thiocholine, which induces aggregation of the AgNPs. Thiocholine 6-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 34012694-6 2021 This fluorescence intensity could be reduced again in the presence of OPs because of the inhibitory effect of OPs on the activity of AChE. OPS 70-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 33916300-3 2021 Among them, only smilagenin and kokusaginine displayed inhibitory action against AChE (IC50 = 43.29 +- 1.38 and 70.24 +- 2.87 microg/mL, respectively). sarsasapogenin 17-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 33916300-3 2021 Among them, only smilagenin and kokusaginine displayed inhibitory action against AChE (IC50 = 43.29 +- 1.38 and 70.24 +- 2.87 microg/mL, respectively). kokusaginine 32-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 33196952-5 2021 Acetylcholinesterase activity was inhibited by proline at 1, 3, and 5 mM. Proline 47-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 33196952-7 2021 Results from Western blot analyses showed that proline at 1 mM after 72 h increased p-NF-kB and decreased acetylcholinesterase immunocontent but did not altered AKT, p-AKT, GSK3beta, and p-GSK3beta. Proline 47-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 33196952-8 2021 Taken together, the data suggest that high proline levels seems to favor the signaling pathways towards cell proliferation, since acetylcholinesterase, which may act as tumor suppressor, is inhibited by proline. Proline 43-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 33196952-8 2021 Taken together, the data suggest that high proline levels seems to favor the signaling pathways towards cell proliferation, since acetylcholinesterase, which may act as tumor suppressor, is inhibited by proline. Proline 203-210 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 33592758-7 2021 Thiol-bearing compounds such as thiocholine generated through the hydrolysis of acetylthiocholine by acetylcholinesterase (AChE) interacted with the surface of CdS QDs thus blocking the ECL. Sulfhydryl Compounds 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 33592758-7 2021 Thiol-bearing compounds such as thiocholine generated through the hydrolysis of acetylthiocholine by acetylcholinesterase (AChE) interacted with the surface of CdS QDs thus blocking the ECL. Sulfhydryl Compounds 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 33592758-7 2021 Thiol-bearing compounds such as thiocholine generated through the hydrolysis of acetylthiocholine by acetylcholinesterase (AChE) interacted with the surface of CdS QDs thus blocking the ECL. Thiocholine 32-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 33592758-7 2021 Thiol-bearing compounds such as thiocholine generated through the hydrolysis of acetylthiocholine by acetylcholinesterase (AChE) interacted with the surface of CdS QDs thus blocking the ECL. Thiocholine 32-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 33592758-7 2021 Thiol-bearing compounds such as thiocholine generated through the hydrolysis of acetylthiocholine by acetylcholinesterase (AChE) interacted with the surface of CdS QDs thus blocking the ECL. Acetylthiocholine 80-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 33592758-7 2021 Thiol-bearing compounds such as thiocholine generated through the hydrolysis of acetylthiocholine by acetylcholinesterase (AChE) interacted with the surface of CdS QDs thus blocking the ECL. Acetylthiocholine 80-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 33497692-5 2021 The present study discusses the identification of two potent AChE inhibitors (ZINC11709541 and ZINC11996936) from ZINC database through conventional in silico approaches and their in vitro validations. zinc11709541 78-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 33497692-5 2021 The present study discusses the identification of two potent AChE inhibitors (ZINC11709541 and ZINC11996936) from ZINC database through conventional in silico approaches and their in vitro validations. ZINC11996936 95-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 33784419-9 2021 Neohesperidin, naringin and meranzin showed inhibitory effect on acetylcholinesterase that regulates gastrointestinal motility in vitro and in silico, suggesting that these three components may be determined as the active biomarkers of Fructus Aurantii. neohesperidin 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 33784419-9 2021 Neohesperidin, naringin and meranzin showed inhibitory effect on acetylcholinesterase that regulates gastrointestinal motility in vitro and in silico, suggesting that these three components may be determined as the active biomarkers of Fructus Aurantii. naringin 15-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 33784419-9 2021 Neohesperidin, naringin and meranzin showed inhibitory effect on acetylcholinesterase that regulates gastrointestinal motility in vitro and in silico, suggesting that these three components may be determined as the active biomarkers of Fructus Aurantii. meranzin 28-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 33592259-1 2021 Organophosphorus compounds (OPs) include nerve agents and insecticides that potently inhibit acetylcholinesterase (AChE), an essential enzyme found throughout the nervous system. Organophosphorus Compounds 0-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 33592259-1 2021 Organophosphorus compounds (OPs) include nerve agents and insecticides that potently inhibit acetylcholinesterase (AChE), an essential enzyme found throughout the nervous system. Organophosphorus Compounds 0-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 33592259-1 2021 Organophosphorus compounds (OPs) include nerve agents and insecticides that potently inhibit acetylcholinesterase (AChE), an essential enzyme found throughout the nervous system. Organophosphorus Compounds 28-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 33592259-1 2021 Organophosphorus compounds (OPs) include nerve agents and insecticides that potently inhibit acetylcholinesterase (AChE), an essential enzyme found throughout the nervous system. Organophosphorus Compounds 28-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 33592259-3 2021 Oximes are a critical piece to the therapeutic regimen which remove the OP from the inhibited AChE and restore normal cholinergic function. Oximes 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 33855299-2 2021 We reported earlier a high acetylcholinesterase inhibitory and antioxidant activity in the chloroform fraction of this plant. Chloroform 91-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 33855299-3 2021 Therefore, this study was designed to explore the compounds with acetylcholinesterase inhibitory and antioxidant activities from the chloroform fraction of Vanda roxburghii. Chloroform 133-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 33855299-3 2021 Therefore, this study was designed to explore the compounds with acetylcholinesterase inhibitory and antioxidant activities from the chloroform fraction of Vanda roxburghii. vanda 156-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 33855299-5 2021 Among the isolates, vanillin (3) and dihydroconiferyl dihydro-p-coumarate (4) were found to significantly inhibit the activity of acetylcholinesterase, scavenge the free radicals, exhibit the reducing power and total antioxidant activity, and effectively reduce the peroxidation of lipid. vanillin 20-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 33855299-5 2021 Among the isolates, vanillin (3) and dihydroconiferyl dihydro-p-coumarate (4) were found to significantly inhibit the activity of acetylcholinesterase, scavenge the free radicals, exhibit the reducing power and total antioxidant activity, and effectively reduce the peroxidation of lipid. dihydroconiferyl dihydro-p-coumarate 37-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 33743158-0 2021 Piperazine-substituted chalcones: a new class of MAO-B, AChE, and BACE-1 inhibitors for the treatment of neurological disorders. Piperazine 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 33743158-0 2021 Piperazine-substituted chalcones: a new class of MAO-B, AChE, and BACE-1 inhibitors for the treatment of neurological disorders. Chalcones 23-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 33645607-3 2021 Two of the heterodimers were significantly stronger acetylcholinesterase inhibitors than the monomeric tacrine. Tacrine 103-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 33645607-4 2021 Molecular modelling indicated that the longer heterodimers fitted better into the active gorge of acetylcholinesterase than the shorter counterparts and the former provided more efficient simultaneous interaction with the tryptophan residues in the catalytic anionic binding site (CAS) and the peripheral anionic binding site (PAS). Tryptophan 222-232 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-118 33460612-2 2021 One option, explored recently, is the synthesis of new analogues of cannabinoids that could competitively inhibit the acetylcholinesterase (AChE) enzyme and showing the classic neuroprotective profile of cannabinoid compounds. Cannabinoids 68-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 33460612-2 2021 One option, explored recently, is the synthesis of new analogues of cannabinoids that could competitively inhibit the acetylcholinesterase (AChE) enzyme and showing the classic neuroprotective profile of cannabinoid compounds. Cannabinoids 68-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 33720374-0 2021 Inhibition Kinetics of 16 Organophosphorus Pesticides or Their Active Metabolites on Erythrocyte Acetylcholinesterase from Humans and Rats. organophosphorus 26-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 33155700-0 2021 Novel benzoic acid derivatives: Synthesis and biological evaluation as multitarget acetylcholinesterase and carbonic anhydrase inhibitors. Benzoic Acid 6-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 33155700-5 2021 In light of these data for understanding and developing AD-related multitarget AChE and hCAs inhibitors, in this study, novel methylene-aminobenzoic acid and tetrahydroisoquinolynyl-benzoic acid derivatives (4a-g and 6a-g) were designed. methylene-aminobenzoic acid 126-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 33155700-5 2021 In light of these data for understanding and developing AD-related multitarget AChE and hCAs inhibitors, in this study, novel methylene-aminobenzoic acid and tetrahydroisoquinolynyl-benzoic acid derivatives (4a-g and 6a-g) were designed. tetrahydroisoquinolynyl-benzoic acid 158-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 33439402-1 2021 Acetylcholinesterase (AChE), one of the major therapeutic strategies for the treatment of Alzheimer"s disease (AD) is to increase the acetylcholine (ACh) level in the brain by inhibiting the biological activity of AChE. Acetylcholine 134-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 33439402-1 2021 Acetylcholinesterase (AChE), one of the major therapeutic strategies for the treatment of Alzheimer"s disease (AD) is to increase the acetylcholine (ACh) level in the brain by inhibiting the biological activity of AChE. Acetylcholine 134-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 33439402-1 2021 Acetylcholinesterase (AChE), one of the major therapeutic strategies for the treatment of Alzheimer"s disease (AD) is to increase the acetylcholine (ACh) level in the brain by inhibiting the biological activity of AChE. Acetylcholine 134-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-218 33439402-1 2021 Acetylcholinesterase (AChE), one of the major therapeutic strategies for the treatment of Alzheimer"s disease (AD) is to increase the acetylcholine (ACh) level in the brain by inhibiting the biological activity of AChE. Acetylcholine 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 33439402-1 2021 Acetylcholinesterase (AChE), one of the major therapeutic strategies for the treatment of Alzheimer"s disease (AD) is to increase the acetylcholine (ACh) level in the brain by inhibiting the biological activity of AChE. Acetylcholine 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-218 33439402-2 2021 In this present work, a set of alkaloids and flavonoids against AChE enzyme were screened by computational chemistry techniques. Flavonoids 45-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 33439402-3 2021 The docking results showed that among alkaloid compounds the oxindole alkaloid namely mitragynine oxidole B (MITOB) and the indole alkaloids namely mitragynine (MIT) exhibited a good binding affinity towards AChE. 2-oxindole 61-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-212 33439402-3 2021 The docking results showed that among alkaloid compounds the oxindole alkaloid namely mitragynine oxidole B (MITOB) and the indole alkaloids namely mitragynine (MIT) exhibited a good binding affinity towards AChE. mitragynine oxidole b 86-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-212 33439402-3 2021 The docking results showed that among alkaloid compounds the oxindole alkaloid namely mitragynine oxidole B (MITOB) and the indole alkaloids namely mitragynine (MIT) exhibited a good binding affinity towards AChE. mitragynine 86-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-212 33439402-5 2021 The binding free energy calculation and ligand-protein binding pattern suggested that both alkaloids could interact with AChE very well. Alkaloids 91-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 33439402-8 2021 This finding provided that the mitragynine compound has the potential to be as a therapeutic agent for further anti-AChE drug development in treatment of Alzheimer"s disease. mitragynine 31-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 32458455-4 2021 The results revealed eugenol, BHT, and BHA inhibited AChE, BChE, and MAO activities dose-dependently. bha 39-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 32458455-5 2021 Though, eugenol had greater inhibitory effect against AChE and BChE activities. Eugenol 8-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 30990078-0 2021 Profiling of acetylcholinesterase inhibitory alkaloids from some Crinum, Habranthus and Zephyranthes species by GC-MS combined with multivariate analyses and in silico studies. Alkaloids 45-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-33 30990078-5 2021 Principal bioactive markers were discovered by correlating AChE inhibitory activity with chemical fingerprints via PLS and OPLS modeling which revealed that galanthamine, lycoramine, caranine, tazettine and N-demethylgalanthamine were the most bio-significant markers. norgalanthamine 207-229 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 30990078-6 2021 Furthermore, the molecular docking was performed to illustrate binding orientations of the top scoring alkaloids in the active site of human acetylcholinesterase. Alkaloids 103-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 30990078-7 2021 Suggested strategy revealed that, beside galanthamine, caranine, N-demethylgalanthamine, and lycoramine are promising AChE inhibitors. CARANINE 55-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 30990078-7 2021 Suggested strategy revealed that, beside galanthamine, caranine, N-demethylgalanthamine, and lycoramine are promising AChE inhibitors. norgalanthamine 65-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 30990078-7 2021 Suggested strategy revealed that, beside galanthamine, caranine, N-demethylgalanthamine, and lycoramine are promising AChE inhibitors. lycoramine 93-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 33652925-6 2021 One of the new compounds, a heterodimer alkaloid of narcikachnine-type, named narciabduliine (2), showed balanced inhibition potency for both studied enzymes, with IC50 values of 3.29 +- 0.73 microM for hAChE and 3.44 +- 0.02 microM for hBuChE. narciabduliine 78-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 203-208 33533366-1 2021 Acute organophosphorus pesticide poisoning (AOPP) is a worldwide health concern that has threatened human lives for decades, which attacks acetylcholinesterase (AChE) and causes nervous system disorders. organophosphorus 6-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-159 33638151-1 2021 We detail here distinctive departures from lead classical cholinesterase reactivators, the pyridinium aldoximes, to achieve rapid CNS penetration and reactivation of AChE in the CNS (brain and spinal cord). pyridine 91-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-72 33638151-1 2021 We detail here distinctive departures from lead classical cholinesterase reactivators, the pyridinium aldoximes, to achieve rapid CNS penetration and reactivation of AChE in the CNS (brain and spinal cord). pyridine 91-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 33638151-3 2021 Thus, the ideal cholinesterase reactivator should show minimal toxicity, limited inhibitory activity in the absence of an organophosphate, and rapid CNS penetration, in addition to its nucleophilic potential at the target, the conjugated AChE active center. Organophosphates 122-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-30 33533366-1 2021 Acute organophosphorus pesticide poisoning (AOPP) is a worldwide health concern that has threatened human lives for decades, which attacks acetylcholinesterase (AChE) and causes nervous system disorders. organophosphorus 6-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-165 33533366-3 2021 As a potential alternative, delivery of mammalian-derived butyrylcholinesterase (BChE) offers a cost-effective way to block organophosphorus attack on acetylcholinesterase, a key enzyme in the neurotransmitter cycle. organophosphorus 124-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-171 33538163-0 2021 Organoselenium Compounds as Acetylcholinesterase Inhibitors: Evidence and Mechanism of Mixed Inhibition. organoselenium 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 33602068-3 2021 Current available drugs are used, mainly, to compensate the decline of the neurotransmitter acetylcholine by acetylcholinesterase (AChE) inhibition, though they only provide temporary symptomatic benefits and cannot stop AD progression. Acetylcholine 92-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 33538163-2 2021 In recent years, the neuroprotective effects of organoselenium compounds such as ebselen and diselenides on the AChE activity have been investigated as potential therapeutic agents. organoselenium 48-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 33538163-2 2021 In recent years, the neuroprotective effects of organoselenium compounds such as ebselen and diselenides on the AChE activity have been investigated as potential therapeutic agents. ebselen 81-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 33538163-2 2021 In recent years, the neuroprotective effects of organoselenium compounds such as ebselen and diselenides on the AChE activity have been investigated as potential therapeutic agents. diselenides 93-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 33538163-3 2021 In this work, we have carried out systematic kinetic and intrinsic fluorescence assays in combination with docking and molecular dynamics (MD) simulations to elucidate the molecular mechanism of the mixed inhibition of AChE by ebselen and diphenyl diselenide (DPDSe) molecules. ebselen 227-234 acetylcholinesterase (Cartwright blood group) Homo sapiens 219-223 33538163-3 2021 In this work, we have carried out systematic kinetic and intrinsic fluorescence assays in combination with docking and molecular dynamics (MD) simulations to elucidate the molecular mechanism of the mixed inhibition of AChE by ebselen and diphenyl diselenide (DPDSe) molecules. diphenyldiselenide 239-258 acetylcholinesterase (Cartwright blood group) Homo sapiens 219-223 33538163-3 2021 In this work, we have carried out systematic kinetic and intrinsic fluorescence assays in combination with docking and molecular dynamics (MD) simulations to elucidate the molecular mechanism of the mixed inhibition of AChE by ebselen and diphenyl diselenide (DPDSe) molecules. diphenyldiselenide 260-265 acetylcholinesterase (Cartwright blood group) Homo sapiens 219-223 33538163-4 2021 Our MD simulations demonstrate significant heterogeneity in the binding modes and allosteric hotspots for DPDSe on AChE due to non-specific interactions. diphenyldiselenide 106-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 33538163-7 2021 Together with results from experiments, these simulations provide mechanistic insights into the mixed type of inhibition for AChE using DPDSe as a promising inhibitor for AChE. diphenyldiselenide 136-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 33538163-7 2021 Together with results from experiments, these simulations provide mechanistic insights into the mixed type of inhibition for AChE using DPDSe as a promising inhibitor for AChE. diphenyldiselenide 136-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 33189440-4 2021 Herein, we report a series of ROS-responsive prodrugs based on multi-target-directed ligands (MTDLs) approach, which can specifically release tacrine derivatives and ibuprofen under oxidation of ROS and show acetylcholinesterase (AChE)-inhibiting, neuron-protective and anti-inflammatory effects in extracellular or intracellular assays. ros 30-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-228 33535742-3 2021 Taking advantages of the remarkable oxidase-mimicking activity, outstanding stability, and reusability of Fe/NPC, a novel dual-channel biosensing system was strategically fabricated for sensitively determining acetylcholinesterase (AChE) through the integration of Fe/NPC and fluorescent silver nanoclusters (AgNCs) for the first time. Silver 288-294 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-230 33535742-3 2021 Taking advantages of the remarkable oxidase-mimicking activity, outstanding stability, and reusability of Fe/NPC, a novel dual-channel biosensing system was strategically fabricated for sensitively determining acetylcholinesterase (AChE) through the integration of Fe/NPC and fluorescent silver nanoclusters (AgNCs) for the first time. Silver 288-294 acetylcholinesterase (Cartwright blood group) Homo sapiens 232-236 33186817-3 2021 This is because that MnO2 NS have oxidized characteristic, and they can react with choline (TCh), which is the product of acetylthiocholine (ATCh) catalyzed by acetylcholinesterase (AChE). manganese dioxide 21-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-186 33186817-3 2021 This is because that MnO2 NS have oxidized characteristic, and they can react with choline (TCh), which is the product of acetylthiocholine (ATCh) catalyzed by acetylcholinesterase (AChE). Choline 83-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-186 33186817-3 2021 This is because that MnO2 NS have oxidized characteristic, and they can react with choline (TCh), which is the product of acetylthiocholine (ATCh) catalyzed by acetylcholinesterase (AChE). thiocarbohydrazide 92-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-186 33186817-3 2021 This is because that MnO2 NS have oxidized characteristic, and they can react with choline (TCh), which is the product of acetylthiocholine (ATCh) catalyzed by acetylcholinesterase (AChE). Acetylthiocholine 122-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-186 33186817-3 2021 This is because that MnO2 NS have oxidized characteristic, and they can react with choline (TCh), which is the product of acetylthiocholine (ATCh) catalyzed by acetylcholinesterase (AChE). Acetylthiocholine 141-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-186 33186817-4 2021 In the presence of OPs, the activity of AChE was inhibited, accompanied by the restraint of the redox reaction of MnO2 NS, therefore the fluorescence of AHNSA was quenched. mno2 ns 114-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 33186817-4 2021 In the presence of OPs, the activity of AChE was inhibited, accompanied by the restraint of the redox reaction of MnO2 NS, therefore the fluorescence of AHNSA was quenched. 1-amino-2-naphthol-4-sulfonic acid 153-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 33668452-3 2021 The hydrazide-hydrazones produced a dual inhibition of both cholinesterase enzymes with IC50 values of 46.8-137.7 microM and 19.1-881.1 microM for AChE and BuChE, respectively. hydrazide-hydrazones 4-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 33583371-4 2021 Tacrine, as the first acetylcholinesterase (AChE) inhibitor, has been discontinued because of its hepatotoxicity, but its core structure is simple and easy to modify. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 33583371-5 2021 By using tacrine to target the catalytic active site (CAS), the tacrine-based MTDLs can act on both CAS and peripheral anion site (PAS) of AChE so as to serve as a dual-site AChE inhibitor. Tacrine 9-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 33583371-5 2021 By using tacrine to target the catalytic active site (CAS), the tacrine-based MTDLs can act on both CAS and peripheral anion site (PAS) of AChE so as to serve as a dual-site AChE inhibitor. Tacrine 9-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 33583371-5 2021 By using tacrine to target the catalytic active site (CAS), the tacrine-based MTDLs can act on both CAS and peripheral anion site (PAS) of AChE so as to serve as a dual-site AChE inhibitor. Tacrine 64-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 33189440-4 2021 Herein, we report a series of ROS-responsive prodrugs based on multi-target-directed ligands (MTDLs) approach, which can specifically release tacrine derivatives and ibuprofen under oxidation of ROS and show acetylcholinesterase (AChE)-inhibiting, neuron-protective and anti-inflammatory effects in extracellular or intracellular assays. ros 30-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 230-234 33583371-5 2021 By using tacrine to target the catalytic active site (CAS), the tacrine-based MTDLs can act on both CAS and peripheral anion site (PAS) of AChE so as to serve as a dual-site AChE inhibitor. Tacrine 64-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 33583373-2 2021 The most successful approach of Alzheimer"s treatment is the administration of cholinesterase inhibitors to prevent the hydrolysis of acetylcholine and subsequently improve the cholinergic postsynaptic transmission. Acetylcholine 134-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-93 33583373-3 2021 This review highlights a class of heterocycle, namely xanthone and its remarkable acetylcholinesterase inhibitory activities. xanthone 54-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 33189440-4 2021 Herein, we report a series of ROS-responsive prodrugs based on multi-target-directed ligands (MTDLs) approach, which can specifically release tacrine derivatives and ibuprofen under oxidation of ROS and show acetylcholinesterase (AChE)-inhibiting, neuron-protective and anti-inflammatory effects in extracellular or intracellular assays. Tacrine 142-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-228 33189440-4 2021 Herein, we report a series of ROS-responsive prodrugs based on multi-target-directed ligands (MTDLs) approach, which can specifically release tacrine derivatives and ibuprofen under oxidation of ROS and show acetylcholinesterase (AChE)-inhibiting, neuron-protective and anti-inflammatory effects in extracellular or intracellular assays. Tacrine 142-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 230-234 33583373-4 2021 Naturally occurring xanthones, including oxygenated, prenylated, pyrano and glycosylated xanthones exhibited promising inhibition effects towards acetylcholinesterase. Xanthones 20-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-166 33583373-4 2021 Naturally occurring xanthones, including oxygenated, prenylated, pyrano and glycosylated xanthones exhibited promising inhibition effects towards acetylcholinesterase. pyrano 65-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-166 33583373-4 2021 Naturally occurring xanthones, including oxygenated, prenylated, pyrano and glycosylated xanthones exhibited promising inhibition effects towards acetylcholinesterase. Xanthones 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-166 33583373-5 2021 Interestingly, synthetic xanthone derivatives with complex substituents such as alkyl, pyrrolidine, piperidine and morpholine have shown greater acetylcholinesterase inhibition activities. xanthone 25-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 33189440-4 2021 Herein, we report a series of ROS-responsive prodrugs based on multi-target-directed ligands (MTDLs) approach, which can specifically release tacrine derivatives and ibuprofen under oxidation of ROS and show acetylcholinesterase (AChE)-inhibiting, neuron-protective and anti-inflammatory effects in extracellular or intracellular assays. Ibuprofen 166-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-228 33583373-5 2021 Interestingly, synthetic xanthone derivatives with complex substituents such as alkyl, pyrrolidine, piperidine and morpholine have shown greater acetylcholinesterase inhibition activities. alkyl 80-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 33189440-4 2021 Herein, we report a series of ROS-responsive prodrugs based on multi-target-directed ligands (MTDLs) approach, which can specifically release tacrine derivatives and ibuprofen under oxidation of ROS and show acetylcholinesterase (AChE)-inhibiting, neuron-protective and anti-inflammatory effects in extracellular or intracellular assays. Ibuprofen 166-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 230-234 33583373-5 2021 Interestingly, synthetic xanthone derivatives with complex substituents such as alkyl, pyrrolidine, piperidine and morpholine have shown greater acetylcholinesterase inhibition activities. pyrrolidine 87-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 33189440-4 2021 Herein, we report a series of ROS-responsive prodrugs based on multi-target-directed ligands (MTDLs) approach, which can specifically release tacrine derivatives and ibuprofen under oxidation of ROS and show acetylcholinesterase (AChE)-inhibiting, neuron-protective and anti-inflammatory effects in extracellular or intracellular assays. ros 195-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-228 33583373-5 2021 Interestingly, synthetic xanthone derivatives with complex substituents such as alkyl, pyrrolidine, piperidine and morpholine have shown greater acetylcholinesterase inhibition activities. piperidine 100-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 33189440-4 2021 Herein, we report a series of ROS-responsive prodrugs based on multi-target-directed ligands (MTDLs) approach, which can specifically release tacrine derivatives and ibuprofen under oxidation of ROS and show acetylcholinesterase (AChE)-inhibiting, neuron-protective and anti-inflammatory effects in extracellular or intracellular assays. ros 195-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 230-234 33583373-5 2021 Interestingly, synthetic xanthone derivatives with complex substituents such as alkyl, pyrrolidine, piperidine and morpholine have shown greater acetylcholinesterase inhibition activities. morpholine 115-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 32827859-2 2021 In this work, based on acetylcholinesterase (AChE) and choline oxidase (CHO), a double-enzymes-mediated Fe2+/Fe3+ conversion as magnetic relaxation switch was explored for the measurement of acetamiprid residue. ammonium ferrous sulfate 104-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 33583373-6 2021 Structure-activity relationship of xanthones revealed that the type and position of substituent(s) attached to the xanthone moiety influenced their acetylcholinesterase inhibition activities where hydrophobic moiety will lead to an improved activity by contributing the pi-pi interactions, as well as the hydroxy substituent(s) by forming hydrogen-bond interactions. Xanthones 35-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-168 33583373-6 2021 Structure-activity relationship of xanthones revealed that the type and position of substituent(s) attached to the xanthone moiety influenced their acetylcholinesterase inhibition activities where hydrophobic moiety will lead to an improved activity by contributing the pi-pi interactions, as well as the hydroxy substituent(s) by forming hydrogen-bond interactions. xanthone 35-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-168 33583373-6 2021 Structure-activity relationship of xanthones revealed that the type and position of substituent(s) attached to the xanthone moiety influenced their acetylcholinesterase inhibition activities where hydrophobic moiety will lead to an improved activity by contributing the pi-pi interactions, as well as the hydroxy substituent(s) by forming hydrogen-bond interactions. Hydrogen 339-347 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-168 33416315-2 2021 Despite the tremendous research efforts in the last decade, only four supportive or palliative drugs, namely, acetylcholinesterase (AChE) inhibitors donepezil, galantamine, and rivastigmine and the glutamate NMDA receptor antagonist memantine, are currently available. Donepezil 149-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 33416315-2 2021 Despite the tremendous research efforts in the last decade, only four supportive or palliative drugs, namely, acetylcholinesterase (AChE) inhibitors donepezil, galantamine, and rivastigmine and the glutamate NMDA receptor antagonist memantine, are currently available. Donepezil 149-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 33563155-14 2022 Further, in-vitro enzymatic assay indicated reasonable reactivation potential of the oximes against paraoxon-inhibited AChE. Oximes 85-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 33563155-14 2022 Further, in-vitro enzymatic assay indicated reasonable reactivation potential of the oximes against paraoxon-inhibited AChE. Paraoxon 100-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 32827859-2 2021 In this work, based on acetylcholinesterase (AChE) and choline oxidase (CHO), a double-enzymes-mediated Fe2+/Fe3+ conversion as magnetic relaxation switch was explored for the measurement of acetamiprid residue. ammonium ferrous sulfate 104-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 32827859-2 2021 In this work, based on acetylcholinesterase (AChE) and choline oxidase (CHO), a double-enzymes-mediated Fe2+/Fe3+ conversion as magnetic relaxation switch was explored for the measurement of acetamiprid residue. ferric sulfate 109-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 32827859-2 2021 In this work, based on acetylcholinesterase (AChE) and choline oxidase (CHO), a double-enzymes-mediated Fe2+/Fe3+ conversion as magnetic relaxation switch was explored for the measurement of acetamiprid residue. ferric sulfate 109-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 32827859-2 2021 In this work, based on acetylcholinesterase (AChE) and choline oxidase (CHO), a double-enzymes-mediated Fe2+/Fe3+ conversion as magnetic relaxation switch was explored for the measurement of acetamiprid residue. acetamiprid 191-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 32827859-2 2021 In this work, based on acetylcholinesterase (AChE) and choline oxidase (CHO), a double-enzymes-mediated Fe2+/Fe3+ conversion as magnetic relaxation switch was explored for the measurement of acetamiprid residue. acetamiprid 191-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 32827859-3 2021 In the double-enzymes reactions, acetylcholine chloride (ACh) can be catalyzed to produce choline by AChE, which is successively hydrolyzed to betaine and hydrogen peroxide (H2O2) by CHO. Acetylcholine 33-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 32827859-3 2021 In the double-enzymes reactions, acetylcholine chloride (ACh) can be catalyzed to produce choline by AChE, which is successively hydrolyzed to betaine and hydrogen peroxide (H2O2) by CHO. Acetylcholine 57-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 32827859-3 2021 In the double-enzymes reactions, acetylcholine chloride (ACh) can be catalyzed to produce choline by AChE, which is successively hydrolyzed to betaine and hydrogen peroxide (H2O2) by CHO. Choline 39-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 32827859-3 2021 In the double-enzymes reactions, acetylcholine chloride (ACh) can be catalyzed to produce choline by AChE, which is successively hydrolyzed to betaine and hydrogen peroxide (H2O2) by CHO. Betaine 143-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 32827859-3 2021 In the double-enzymes reactions, acetylcholine chloride (ACh) can be catalyzed to produce choline by AChE, which is successively hydrolyzed to betaine and hydrogen peroxide (H2O2) by CHO. Hydrogen Peroxide 155-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 32827859-3 2021 In the double-enzymes reactions, acetylcholine chloride (ACh) can be catalyzed to produce choline by AChE, which is successively hydrolyzed to betaine and hydrogen peroxide (H2O2) by CHO. Hydrogen Peroxide 174-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 32827859-4 2021 According to the enzyme inhibition principle, AChE activity will be inactivated in the presence of acetamiprid, thus leading to the less production of H2O2. acetamiprid 99-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 32827859-4 2021 According to the enzyme inhibition principle, AChE activity will be inactivated in the presence of acetamiprid, thus leading to the less production of H2O2. Hydrogen Peroxide 151-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 33538985-0 2022 Synthesis of 8-phenyl substituted 3-benzazecines with allene moiety, their thermal rearrangement and evaluation as acetylcholinesterase inhibitors. 8-phenyl substituted 3-benzazecines 13-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 33538985-0 2022 Synthesis of 8-phenyl substituted 3-benzazecines with allene moiety, their thermal rearrangement and evaluation as acetylcholinesterase inhibitors. propadiene 54-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 33538985-3 2022 Among the tested compounds, the allene derivative 2g proved to competitively inhibit human AChE with inhibition constant value (Ki) in the low micromolar range. propadiene 32-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 33540879-6 2021 Dual-drug combinations of berberine and tacrine (BerTac), berberine and galantamine (BerGal), and tacrine and donepezil (TacDon) all produced synergistic outcomes for AChE inhibition. Tacrine 98-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 33540879-6 2021 Dual-drug combinations of berberine and tacrine (BerTac), berberine and galantamine (BerGal), and tacrine and donepezil (TacDon) all produced synergistic outcomes for AChE inhibition. Donepezil 110-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 33540879-6 2021 Dual-drug combinations of berberine and tacrine (BerTac), berberine and galantamine (BerGal), and tacrine and donepezil (TacDon) all produced synergistic outcomes for AChE inhibition. tacdon 121-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 33540879-8 2021 Donepezil and galantamine (DonGal) was synergistic for human AChE but antagonistic for tcAChE. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 33540879-8 2021 Donepezil and galantamine (DonGal) was synergistic for human AChE but antagonistic for tcAChE. Galantamine 14-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 33708959-10 2021 The effects were abolished by atropine and the selective M1 mAChR antagonist pirenzepine in OGD-induced PRNs suggesting an indirect M1 mAChR-mediated effect via inhibiting AChE activity to increase endogenous ACh level. Atropine 30-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-176 33708959-10 2021 The effects were abolished by atropine and the selective M1 mAChR antagonist pirenzepine in OGD-induced PRNs suggesting an indirect M1 mAChR-mediated effect via inhibiting AChE activity to increase endogenous ACh level. Pirenzepine 77-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-176 32997390-4 2021 The novel inositols (11-17) had effective inhibition profiles against human carbonic anhydrase isoenzymes I and II (hCA I and II) and acetylcholinesterase (AChE). Inositol 10-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-154 32997390-4 2021 The novel inositols (11-17) had effective inhibition profiles against human carbonic anhydrase isoenzymes I and II (hCA I and II) and acetylcholinesterase (AChE). Inositol 10-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-160 32997390-5 2021 The novel inositols 11-17 were found to be effective inhibitors against AChE, hCA I, and hCA II enzymes. Inositol 10-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 33383322-9 2021 Hydrazine-1-carbothioamide and hydroxybenzylidene moieties of compounds play an important role in the inhibition of AChE, hCA I, and hCA II enzymes. hydrazine-1-carbothioamide 0-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 33383322-9 2021 Hydrazine-1-carbothioamide and hydroxybenzylidene moieties of compounds play an important role in the inhibition of AChE, hCA I, and hCA II enzymes. hydroxybenzylidene 31-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 33387730-8 2021 Significant human AChE/BuChE (hAChE/hBuChE) inhibitory activity was demonstrated by the newly described alkaloid narcieliine (3), with IC50 values of 18.7 +- 2.3 microM and 1.34 +- 0.31 microM, respectively. narcieliine 113-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-35 33421953-1 2021 A series of tacrine - benzothiazole hybrids incorporate inhibitors of acetylcholinesterase (AChE), amyloid beta (Abeta) aggregation and mitochondrial enzyme ABAD, whose interaction with Abeta leads to mitochondrial dysfunction, into a single molecule. Tacrine 12-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 33421953-1 2021 A series of tacrine - benzothiazole hybrids incorporate inhibitors of acetylcholinesterase (AChE), amyloid beta (Abeta) aggregation and mitochondrial enzyme ABAD, whose interaction with Abeta leads to mitochondrial dysfunction, into a single molecule. Tacrine 12-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 33421953-1 2021 A series of tacrine - benzothiazole hybrids incorporate inhibitors of acetylcholinesterase (AChE), amyloid beta (Abeta) aggregation and mitochondrial enzyme ABAD, whose interaction with Abeta leads to mitochondrial dysfunction, into a single molecule. benzothiazole 22-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 33421953-1 2021 A series of tacrine - benzothiazole hybrids incorporate inhibitors of acetylcholinesterase (AChE), amyloid beta (Abeta) aggregation and mitochondrial enzyme ABAD, whose interaction with Abeta leads to mitochondrial dysfunction, into a single molecule. benzothiazole 22-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 33476865-7 2021 Isoindoline-1,3-dione and benzothiophene moieties played a critical role in the inhibition of AChE and BChE enzymes, respectively. isoindoline-1,3-dione 0-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 33476865-7 2021 Isoindoline-1,3-dione and benzothiophene moieties played a critical role in the inhibition of AChE and BChE enzymes, respectively. benzothiophene 26-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 33448662-8 2021 Particularly, five TAC-menbutone molecules showed improved AChE and Abeta aggregation inhibition capacity compared to TAC-fenbufen conjugated molecules. tac-menbutone 19-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 33059211-0 2021 Acetylcholinesterase activity in fish species exposed to crude oil hydrocarbons: A review and new perspectives. oil hydrocarbons 63-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 33346126-7 2021 And the HAR-NC-IG could significantly inhibit the expression of acetylcholinesterase (AchE) and increase the content of acetylcholin (ACh) in brain compared with those of reference formulations (p <0.01). acetylcholin 64-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 32013770-2 2021 Zinc metal carboxylates (AAZ1 - AAZ6) were evaluated against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Zinc 0-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 32146656-0 2021 Synthesis, biological evaluation, theoretical investigations, docking study and ADME parameters of some 1,4-bisphenylhydrazone derivatives as potent antioxidant agents and acetylcholinesterase inhibitors. 1,4-bisphenylhydrazone 104-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-192 32146656-1 2021 Five 1,4-bisphenylhydrazone derivatives (1-5) were successfully synthesized and evaluated for their antioxidant and acetylcholinesterase inhibitory activities. 1,4-bisphenylhydrazone 5-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 32146656-6 2021 The obtained results indicate that compound 2 is the best acetylcholinesterase inhibitor with a low IC50 value comparable to that of the galantamine. Galantamine 137-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 32577882-5 2021 Since then, the combination of rectal mucosal biopsy and rubeanic acid-amplificated AChE staining has been brought about by the following milestones: the discovery that the submucosal plexus and the intermuscular plexus had the same level of nerve migration; the findings of research on acetylcholine (ACh) and acetylcholinesterase (AChE) in the intestinal tract; and the establishment of a rubeanic acid amplification method. rubeanic acid 57-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 32577882-5 2021 Since then, the combination of rectal mucosal biopsy and rubeanic acid-amplificated AChE staining has been brought about by the following milestones: the discovery that the submucosal plexus and the intermuscular plexus had the same level of nerve migration; the findings of research on acetylcholine (ACh) and acetylcholinesterase (AChE) in the intestinal tract; and the establishment of a rubeanic acid amplification method. rubeanic acid 57-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 311-331 32577882-5 2021 Since then, the combination of rectal mucosal biopsy and rubeanic acid-amplificated AChE staining has been brought about by the following milestones: the discovery that the submucosal plexus and the intermuscular plexus had the same level of nerve migration; the findings of research on acetylcholine (ACh) and acetylcholinesterase (AChE) in the intestinal tract; and the establishment of a rubeanic acid amplification method. rubeanic acid 57-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 333-337 32577882-5 2021 Since then, the combination of rectal mucosal biopsy and rubeanic acid-amplificated AChE staining has been brought about by the following milestones: the discovery that the submucosal plexus and the intermuscular plexus had the same level of nerve migration; the findings of research on acetylcholine (ACh) and acetylcholinesterase (AChE) in the intestinal tract; and the establishment of a rubeanic acid amplification method. Acetylcholine 287-300 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 32577882-5 2021 Since then, the combination of rectal mucosal biopsy and rubeanic acid-amplificated AChE staining has been brought about by the following milestones: the discovery that the submucosal plexus and the intermuscular plexus had the same level of nerve migration; the findings of research on acetylcholine (ACh) and acetylcholinesterase (AChE) in the intestinal tract; and the establishment of a rubeanic acid amplification method. rubeanic acid 391-404 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 33544523-5 2021 However, berberine (IC50=0.17 mg/mL) had slight higher AChE inhibitory effect than piperine and neostigmine (p<0.05). Berberine 9-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 33544523-9 2021 The modulatory and antioxidant berberine and piperine properties on these enzymes (AChE, BChE and MAO) could be possible underlying mechanisms in employing these compounds as a complementary therapy in neurodegenerative diseases (NDDs) management. Berberine 31-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 33544523-9 2021 The modulatory and antioxidant berberine and piperine properties on these enzymes (AChE, BChE and MAO) could be possible underlying mechanisms in employing these compounds as a complementary therapy in neurodegenerative diseases (NDDs) management. piperine 45-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 33585459-1 2020 Acetylcholinesterase (AChE), an enzyme catalyzing the degradation of acetylcholine, plays an important suppressive role in the cholinergic regulation by terminating the action of acetylcholine. Acetylcholine 69-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 33585459-1 2020 Acetylcholinesterase (AChE), an enzyme catalyzing the degradation of acetylcholine, plays an important suppressive role in the cholinergic regulation by terminating the action of acetylcholine. Acetylcholine 69-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 33585459-1 2020 Acetylcholinesterase (AChE), an enzyme catalyzing the degradation of acetylcholine, plays an important suppressive role in the cholinergic regulation by terminating the action of acetylcholine. Acetylcholine 179-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 33585459-1 2020 Acetylcholinesterase (AChE), an enzyme catalyzing the degradation of acetylcholine, plays an important suppressive role in the cholinergic regulation by terminating the action of acetylcholine. Acetylcholine 179-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 33513837-9 2021 N-(3-chlorophenyl)-2-((8-methyl-2-(piperidin-1-yl)quinolin-3-yl)methylene)hydrazine carbothioamide emerged as the most potent dual inhibitor of AChE and BChE with IC50 values of 9.68 and 11.59 muM, respectively. n-(3-chlorophenyl)-2-((8-methyl-2-(piperidin-1-yl)quinolin-3-yl)methylene)hydrazine carbothioamide 0-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 33320652-9 2021 Three of the 24 compounds (compounds 10b, 10h, and 10i) based on a 6-(2-(pyrrolidin-1-yl)pyrimidin-4-yl)-thiazolo[3,2-a]pyrimidine scaffold showed highly promising AChE inhibition ability with IC50 values of 13.10 +- 0.53, 16.02 +- 0.46, and 6.22 +- 0.54 muM, respectively. 6-(2-(pyrrolidin-1-yl)pyrimidin-4-yl)-thiazolo[3,2-a]pyrimidine 67-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 33320652-12 2021 Interaction analysis reveals that hydrophobic and hydrogen-bonding interactions are the primary driving forces responsible for the observed high affinity of the compound with AChE. Hydrogen 50-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 175-179 33519199-10 2021 GW4869 inhibits PtNPs induced biogenesis and release of exosomes and also acetylcholinesterase (AChE), neutral sphingomyelinase activity (n-SMase), and exosome counts. GW 4869 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 33480334-6 2021 The Pt (II) complex showed the most potent inhibitory property against all of the enzymes with IC50 values of 12 microM for AChE, 23 microM for BChE, and 21 microM for CEase. pt (ii) 4-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 33482834-5 2021 We found that the derived Tf-PL/AChE liposomes exhibited much higher transfection efficiency than the commercial product Lipo 2000 and shown premium targeting efficacy to liver cancer SMMC-7721 cells in vitro. tf-pl 26-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 33482834-5 2021 We found that the derived Tf-PL/AChE liposomes exhibited much higher transfection efficiency than the commercial product Lipo 2000 and shown premium targeting efficacy to liver cancer SMMC-7721 cells in vitro. lipo 2000 121-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 33406172-1 2021 Herein, combined with a pervasive smartphone installed with a color recognition app, dual-responsive CDs@Eu/GMP ICPs were designed as a red-to-blue paper-based colorimetric sensor for the point-of-use analysis of cerebral acetylcholinesterase (AChE) upon Cd2+ exposure. Cadmium 101-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 222-242 33406172-1 2021 Herein, combined with a pervasive smartphone installed with a color recognition app, dual-responsive CDs@Eu/GMP ICPs were designed as a red-to-blue paper-based colorimetric sensor for the point-of-use analysis of cerebral acetylcholinesterase (AChE) upon Cd2+ exposure. Cadmium 101-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 244-248 33406172-3 2021 With the presence of thiocholine (TCh), derived from acetylthiocholine (ATCh) hydrolyzed by AChE, the coordination environment of the CDs@Eu/GMP ICPs was interrupted, leading to the collapse of the CDs@Eu/GMP ICP network and the corresponding release of guest CDs into the surrounding environment. Thiocholine 21-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 33406172-3 2021 With the presence of thiocholine (TCh), derived from acetylthiocholine (ATCh) hydrolyzed by AChE, the coordination environment of the CDs@Eu/GMP ICPs was interrupted, leading to the collapse of the CDs@Eu/GMP ICP network and the corresponding release of guest CDs into the surrounding environment. Thiocholine 34-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 33406172-3 2021 With the presence of thiocholine (TCh), derived from acetylthiocholine (ATCh) hydrolyzed by AChE, the coordination environment of the CDs@Eu/GMP ICPs was interrupted, leading to the collapse of the CDs@Eu/GMP ICP network and the corresponding release of guest CDs into the surrounding environment. Acetylthiocholine 53-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 33406172-3 2021 With the presence of thiocholine (TCh), derived from acetylthiocholine (ATCh) hydrolyzed by AChE, the coordination environment of the CDs@Eu/GMP ICPs was interrupted, leading to the collapse of the CDs@Eu/GMP ICP network and the corresponding release of guest CDs into the surrounding environment. Acetylthiocholine 72-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 33406172-3 2021 With the presence of thiocholine (TCh), derived from acetylthiocholine (ATCh) hydrolyzed by AChE, the coordination environment of the CDs@Eu/GMP ICPs was interrupted, leading to the collapse of the CDs@Eu/GMP ICP network and the corresponding release of guest CDs into the surrounding environment. Cadmium 134-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 33406172-3 2021 With the presence of thiocholine (TCh), derived from acetylthiocholine (ATCh) hydrolyzed by AChE, the coordination environment of the CDs@Eu/GMP ICPs was interrupted, leading to the collapse of the CDs@Eu/GMP ICP network and the corresponding release of guest CDs into the surrounding environment. Cadmium 198-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 33406172-3 2021 With the presence of thiocholine (TCh), derived from acetylthiocholine (ATCh) hydrolyzed by AChE, the coordination environment of the CDs@Eu/GMP ICPs was interrupted, leading to the collapse of the CDs@Eu/GMP ICP network and the corresponding release of guest CDs into the surrounding environment. guanosine 5'-monophosphorothioate 141-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 33406172-3 2021 With the presence of thiocholine (TCh), derived from acetylthiocholine (ATCh) hydrolyzed by AChE, the coordination environment of the CDs@Eu/GMP ICPs was interrupted, leading to the collapse of the CDs@Eu/GMP ICP network and the corresponding release of guest CDs into the surrounding environment. Cadmium 198-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 33406172-5 2021 This obvious red-to-blue fluorescent color changes of CDs@Eu/GMP ICPs on test paper could then be integrated with the smartphone for point-of-use analysis of cerebral AChE upon Cd2+ exposure, which not only offers a new analytical platform for a better understanding of the environmental risk of Alzheimer"s Dementia (AD), but also holds great potential in the early diagnosis of AD even at the asymptomatic stage with the decrease in CSF AChE as an early biomarker. Cadmium 54-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 33406172-5 2021 This obvious red-to-blue fluorescent color changes of CDs@Eu/GMP ICPs on test paper could then be integrated with the smartphone for point-of-use analysis of cerebral AChE upon Cd2+ exposure, which not only offers a new analytical platform for a better understanding of the environmental risk of Alzheimer"s Dementia (AD), but also holds great potential in the early diagnosis of AD even at the asymptomatic stage with the decrease in CSF AChE as an early biomarker. Cadmium 54-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 439-443 33479045-4 2021 Exposure to carbamate and organophosphate insecticides was assessed using haemoglobin-adjusted erythrocyte acetylcholinesterase (AChE/Hb). Carbamates 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 33280706-0 2021 An ultra-sensitive and selective AChE based colorimetric detection of malathion using silver nanoparticle-graphene oxide (Ag-GO) nanocomposite. Malathion 70-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 33338868-0 2021 Conjugation of tacrine with genipin derivative not only enhances effects on AChE but also leads to autophagy against Alzheimer"s disease. Tacrine 15-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 33338868-0 2021 Conjugation of tacrine with genipin derivative not only enhances effects on AChE but also leads to autophagy against Alzheimer"s disease. genipin 28-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 33338868-2 2021 Compound 8-7 was confirmed as the most active AChE inhibitor with IC50 value of 5.8 +- 1.4 nM, which was 7.72-fold stronger than tacrine. Tacrine 129-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 33356266-1 2021 The combination of the scaffolds of the cholinesterase inhibitor huprine Y and the antioxidant capsaicin results in compounds with nanomolar potencies toward human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) that retain or improve the antioxidant properties of capsaicin. huprine Y 65-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-184 33356266-1 2021 The combination of the scaffolds of the cholinesterase inhibitor huprine Y and the antioxidant capsaicin results in compounds with nanomolar potencies toward human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) that retain or improve the antioxidant properties of capsaicin. huprine Y 65-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 33356266-1 2021 The combination of the scaffolds of the cholinesterase inhibitor huprine Y and the antioxidant capsaicin results in compounds with nanomolar potencies toward human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) that retain or improve the antioxidant properties of capsaicin. Capsaicin 95-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-184 33356266-1 2021 The combination of the scaffolds of the cholinesterase inhibitor huprine Y and the antioxidant capsaicin results in compounds with nanomolar potencies toward human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) that retain or improve the antioxidant properties of capsaicin. Capsaicin 95-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 33417724-6 2021 RESULTS: The sensitivity, specificity, accuracy and Kappa index of AChE histochemistry and HE staining were 94.1%, 100%, 98.9% and 0.964 and 76.5%, 84.9%, 83.3% and 0.530, respectively, with the specificity, accuracy and Kappa index of AChE histochemistry significantly higher than those of HE staining (p<0.001, p<0.001 and p<0.05). Helium 291-293 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 33057486-0 2021 Light-accelerating oxidase-mimicking activity of black phosphorus quantum dots for colorimetric detection of acetylcholinesterase activity and inhibitor screening. Phosphorus 55-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-129 33057486-1 2021 A feasible and sensitive colorimetric platform was established for the assay of acetylcholinesterase (AChE) activity and evaluation of its inhibitor screening, based upon the light-accelerating oxidase-mimicking activity of black phosphorus quantum dots (BP QDs). Phosphorus 230-240 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 33057486-1 2021 A feasible and sensitive colorimetric platform was established for the assay of acetylcholinesterase (AChE) activity and evaluation of its inhibitor screening, based upon the light-accelerating oxidase-mimicking activity of black phosphorus quantum dots (BP QDs). Phosphorus 230-240 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 33057486-6 2021 AChE can specifically catalyze the decomposition of its substrate acetylthiocholine chloride to thiocholine. Acetylthiocholine chloride 66-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 33057486-6 2021 AChE can specifically catalyze the decomposition of its substrate acetylthiocholine chloride to thiocholine. Thiocholine 72-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 33615172-3 2021 All these drugs were found to exhibit moderate to strong inhibitory efficiency on the neurotransmitter degrading enzyme acetylcholinesterase (AChE) with GLY (IC50 = 0.74 +- 0.02 muM) being the most potent, followed by CPM (IC50 = 5.72 +- 0.24 muM) and TBM (IC50 = 28.9 +- 1.60 muM). Glyburide 153-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 33615172-3 2021 All these drugs were found to exhibit moderate to strong inhibitory efficiency on the neurotransmitter degrading enzyme acetylcholinesterase (AChE) with GLY (IC50 = 0.74 +- 0.02 muM) being the most potent, followed by CPM (IC50 = 5.72 +- 0.24 muM) and TBM (IC50 = 28.9 +- 1.60 muM). Tolbutamide 252-255 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 33615172-5 2021 The larger size of GLY spans almost the full gorge of AChE ranging from catalytic active site (CAS) to the peripheral active site (PAS) with relatively strong binding affinity (6.0 x 105 M-1) and acts as a competitive inhibitor for AChE. Glyburide 19-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 33615172-5 2021 The larger size of GLY spans almost the full gorge of AChE ranging from catalytic active site (CAS) to the peripheral active site (PAS) with relatively strong binding affinity (6.0 x 105 M-1) and acts as a competitive inhibitor for AChE. Glyburide 19-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 232-236 33615172-9 2021 The consequential side effect of excess acetylcholine production, due to the administration of these drugs to AD-unaffected patients, can be rectified by using colloidal gold and silver nanofluids as potential AChE activity boosters. Acetylcholine 40-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-214 33615172-9 2021 The consequential side effect of excess acetylcholine production, due to the administration of these drugs to AD-unaffected patients, can be rectified by using colloidal gold and silver nanofluids as potential AChE activity boosters. Silver 179-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-214 33280706-0 2021 An ultra-sensitive and selective AChE based colorimetric detection of malathion using silver nanoparticle-graphene oxide (Ag-GO) nanocomposite. silver nanoparticle-graphene oxide 86-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 33280706-0 2021 An ultra-sensitive and selective AChE based colorimetric detection of malathion using silver nanoparticle-graphene oxide (Ag-GO) nanocomposite. ag-go 122-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 33280706-1 2021 Herein, we propose rapid, precise acetylcholinesterase (AChE) inhibition-based sensing strategy for malathion detection in the presence of Ag-GO and acetylthiocholine (ATCh). Malathion 100-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 33280706-1 2021 Herein, we propose rapid, precise acetylcholinesterase (AChE) inhibition-based sensing strategy for malathion detection in the presence of Ag-GO and acetylthiocholine (ATCh). Malathion 100-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 33280706-1 2021 Herein, we propose rapid, precise acetylcholinesterase (AChE) inhibition-based sensing strategy for malathion detection in the presence of Ag-GO and acetylthiocholine (ATCh). ag-go 139-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 33280706-1 2021 Herein, we propose rapid, precise acetylcholinesterase (AChE) inhibition-based sensing strategy for malathion detection in the presence of Ag-GO and acetylthiocholine (ATCh). ag-go 139-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 33280706-1 2021 Herein, we propose rapid, precise acetylcholinesterase (AChE) inhibition-based sensing strategy for malathion detection in the presence of Ag-GO and acetylthiocholine (ATCh). Acetylthiocholine 149-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 32334495-0 2021 Review about structure and evaluation of reactivators of Acetylcholinesterase inhibited with neurotoxic organophosphorus compounds. organophosphorus 104-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 32334495-2 2021 The most effective of those agents are the organophosphates (OPs) capable of restricting the enzyme acetylcholinesterase (AChE), which in turn controls the nerve impulse transmission. Organophosphates 43-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 32334495-2 2021 The most effective of those agents are the organophosphates (OPs) capable of restricting the enzyme acetylcholinesterase (AChE), which in turn controls the nerve impulse transmission. Organophosphates 43-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 32334495-2 2021 The most effective of those agents are the organophosphates (OPs) capable of restricting the enzyme acetylcholinesterase (AChE), which in turn controls the nerve impulse transmission. Organophosphates 61-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 32334495-2 2021 The most effective of those agents are the organophosphates (OPs) capable of restricting the enzyme acetylcholinesterase (AChE), which in turn controls the nerve impulse transmission. Organophosphates 61-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 32334495-3 2021 When AChE is inhibited by OPs, its reactivation can be usually performed through cationic oximes. Organophosphates 26-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 32334495-3 2021 When AChE is inhibited by OPs, its reactivation can be usually performed through cationic oximes. Oximes 90-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 33100197-2 2021 The most worldwide famous acetylcholinesterase inhibitor (AChEIs) donepezil for its dominant role in Alzheimer"s disease (AD) has also attracted the eyes of many pharmaceuticals regarding its promising pharmacological potencies such as neuroprotective, muscle relaxant, and sleep. Donepezil 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 33049692-2 2021 Acute exposure of humans to these mixtures induces the covalent modification of acetylcholinesterase (AChE) and neuropathy target esterase (NTE) and causes a cholinergic syndrome or organophosphate-induced delayed polyneuropathy syndrome (OPIDP). Organophosphates 182-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 33560903-2 2021 Malathion (MT) is one of the most widely used organophosphorus insecticides which induces toxicity through oxidative stress induction, free radical production and acetylcholinesterase inhibition. Malathion 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-183 33560903-2 2021 Malathion (MT) is one of the most widely used organophosphorus insecticides which induces toxicity through oxidative stress induction, free radical production and acetylcholinesterase inhibition. Malathion 11-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-183 33317809-0 2021 Corrigendum to "Effects of astrocyte conditioned medium on neuronal AChE expression upon 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure" [Chem. Polychlorinated Dibenzodioxins 89-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 33280706-1 2021 Herein, we propose rapid, precise acetylcholinesterase (AChE) inhibition-based sensing strategy for malathion detection in the presence of Ag-GO and acetylthiocholine (ATCh). Acetylthiocholine 149-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 33280706-1 2021 Herein, we propose rapid, precise acetylcholinesterase (AChE) inhibition-based sensing strategy for malathion detection in the presence of Ag-GO and acetylthiocholine (ATCh). Acetylthiocholine 168-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 33280706-1 2021 Herein, we propose rapid, precise acetylcholinesterase (AChE) inhibition-based sensing strategy for malathion detection in the presence of Ag-GO and acetylthiocholine (ATCh). Acetylthiocholine 168-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 33280706-5 2021 While the addition of malathion into the sensing system hindered the AChE activity and limited the TCh production, and thus inhibits the decrease in the SPR band intensity. Malathion 22-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 33197743-0 2021 Voacafrines A-N, aspidosperma-type monoterpenoid indole alkaloids from Voacanga africana with AChE inhibitory activity. voacafrines a-n 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 33197743-0 2021 Voacafrines A-N, aspidosperma-type monoterpenoid indole alkaloids from Voacanga africana with AChE inhibitory activity. aspidosperma-type monoterpenoid indole alkaloids 17-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 33197743-6 2021 Voacafrines A-C and E-G were bisindole alkaloids that exhibited AChE inhibitory activity with IC50 values of 4.97-33.28 muM, while voacafrines I and J were monomers that showed cytotoxicity against several human cancer cell lines with IC50 values of 4.45-7.49 muM. voacafrines a-c and e-g 0-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 33197743-6 2021 Voacafrines A-C and E-G were bisindole alkaloids that exhibited AChE inhibitory activity with IC50 values of 4.97-33.28 muM, while voacafrines I and J were monomers that showed cytotoxicity against several human cancer cell lines with IC50 values of 4.45-7.49 muM. bisindole alkaloids 29-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 33076048-3 2021 When AChE was introduced, acetylthiocholine could be hydrolyzed to generate thiocholine, which efficiently triggered the reduction of MnO2 NSs into Mn2+, resulting in the decrease of fluorescence. Acetylthiocholine 26-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 33424364-2 2021 Among the spiropyrrolidine heterocyclic hybrids, the indole based fluorinated compound with a methoxy substituent at the meta- position of the aryl ring exhibited the utmost potent AChE and BChE inhibitory activities with an IC50 of 1.97 +- 0.19 microM and 7.08 +- 0.20 microM respectively. spiropyrrolidine 10-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 33424364-2 2021 Among the spiropyrrolidine heterocyclic hybrids, the indole based fluorinated compound with a methoxy substituent at the meta- position of the aryl ring exhibited the utmost potent AChE and BChE inhibitory activities with an IC50 of 1.97 +- 0.19 microM and 7.08 +- 0.20 microM respectively. indole 53-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 33076046-2 2021 The sensing assay is based on the "quenched off" state of bimetallic NC with the addition of Cu2+ ions that can be "switched on" due to generation of thiocholine (TCh), a catalytic product of enzymatic reaction of acetylthiocholine (ATCh) using acetylcholinesterase (AChE) enzyme. cupric ion 93-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 245-265 33076048-6 2021 This biosensor obtained a good linear range from 0.02 to 1 mU/mL and an extremely low detection limit of 15 muU/mL for AChE assay, as well as a sensitive screening for tacrine and an excellent applicability in human serum samples. Tacrine 168-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 33076046-2 2021 The sensing assay is based on the "quenched off" state of bimetallic NC with the addition of Cu2+ ions that can be "switched on" due to generation of thiocholine (TCh), a catalytic product of enzymatic reaction of acetylthiocholine (ATCh) using acetylcholinesterase (AChE) enzyme. cupric ion 93-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 267-271 33076046-2 2021 The sensing assay is based on the "quenched off" state of bimetallic NC with the addition of Cu2+ ions that can be "switched on" due to generation of thiocholine (TCh), a catalytic product of enzymatic reaction of acetylthiocholine (ATCh) using acetylcholinesterase (AChE) enzyme. Thiocholine 150-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 245-265 33076046-2 2021 The sensing assay is based on the "quenched off" state of bimetallic NC with the addition of Cu2+ ions that can be "switched on" due to generation of thiocholine (TCh), a catalytic product of enzymatic reaction of acetylthiocholine (ATCh) using acetylcholinesterase (AChE) enzyme. Thiocholine 150-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 267-271 33076046-2 2021 The sensing assay is based on the "quenched off" state of bimetallic NC with the addition of Cu2+ ions that can be "switched on" due to generation of thiocholine (TCh), a catalytic product of enzymatic reaction of acetylthiocholine (ATCh) using acetylcholinesterase (AChE) enzyme. Thiocholine 163-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 245-265 33076046-2 2021 The sensing assay is based on the "quenched off" state of bimetallic NC with the addition of Cu2+ ions that can be "switched on" due to generation of thiocholine (TCh), a catalytic product of enzymatic reaction of acetylthiocholine (ATCh) using acetylcholinesterase (AChE) enzyme. Thiocholine 163-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 267-271 33076046-2 2021 The sensing assay is based on the "quenched off" state of bimetallic NC with the addition of Cu2+ ions that can be "switched on" due to generation of thiocholine (TCh), a catalytic product of enzymatic reaction of acetylthiocholine (ATCh) using acetylcholinesterase (AChE) enzyme. Acetylthiocholine 214-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 245-265 33076046-2 2021 The sensing assay is based on the "quenched off" state of bimetallic NC with the addition of Cu2+ ions that can be "switched on" due to generation of thiocholine (TCh), a catalytic product of enzymatic reaction of acetylthiocholine (ATCh) using acetylcholinesterase (AChE) enzyme. Acetylthiocholine 214-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 267-271 33076046-4 2021 The presence of ethyl parathion can be monitored optically due to its inhibitory action towards AChE enzyme leading to suppression of thiocholine (TCh) formation and subsequently decreases TCh-Cu2+ interaction that ultimately retrieved quenched off state of bimetallic NC. Parathion 16-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 33076046-4 2021 The presence of ethyl parathion can be monitored optically due to its inhibitory action towards AChE enzyme leading to suppression of thiocholine (TCh) formation and subsequently decreases TCh-Cu2+ interaction that ultimately retrieved quenched off state of bimetallic NC. Thiocholine 134-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 33076046-4 2021 The presence of ethyl parathion can be monitored optically due to its inhibitory action towards AChE enzyme leading to suppression of thiocholine (TCh) formation and subsequently decreases TCh-Cu2+ interaction that ultimately retrieved quenched off state of bimetallic NC. Thiocholine 147-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 33076046-4 2021 The presence of ethyl parathion can be monitored optically due to its inhibitory action towards AChE enzyme leading to suppression of thiocholine (TCh) formation and subsequently decreases TCh-Cu2+ interaction that ultimately retrieved quenched off state of bimetallic NC. Thiocholine 189-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 33076046-4 2021 The presence of ethyl parathion can be monitored optically due to its inhibitory action towards AChE enzyme leading to suppression of thiocholine (TCh) formation and subsequently decreases TCh-Cu2+ interaction that ultimately retrieved quenched off state of bimetallic NC. cupric ion 193-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 33076048-0 2021 A thiamine-triggered fluormetric assay for acetylcholinesterase activity and inhibitor screening based on oxidase-like activity of MnO2 nanosheets. Thiamine 2-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 33076048-3 2021 When AChE was introduced, acetylthiocholine could be hydrolyzed to generate thiocholine, which efficiently triggered the reduction of MnO2 NSs into Mn2+, resulting in the decrease of fluorescence. Thiocholine 32-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 33076048-3 2021 When AChE was introduced, acetylthiocholine could be hydrolyzed to generate thiocholine, which efficiently triggered the reduction of MnO2 NSs into Mn2+, resulting in the decrease of fluorescence. manganese dioxide 134-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 33076048-3 2021 When AChE was introduced, acetylthiocholine could be hydrolyzed to generate thiocholine, which efficiently triggered the reduction of MnO2 NSs into Mn2+, resulting in the decrease of fluorescence. Manganese(2+) 148-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 33076048-4 2021 Owing to the inhibiting effect of tacrine to the AChE activity, the decomposition of MnO2 was hindered, thus leading to the fluorescence recovery. Tacrine 34-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 33076048-4 2021 Owing to the inhibiting effect of tacrine to the AChE activity, the decomposition of MnO2 was hindered, thus leading to the fluorescence recovery. manganese dioxide 85-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 33728848-1 2021 OBJECTIVE: To evaluate the efficacy of the AChE inhibitor ipidacrine when added to traditional therapy in outpatients with tunnel syndromes (TS) based on clinical, neurophysiological and psycho-emotional indicators. amiridine 58-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 33382027-3 2020 The crystal structure of galantamine bound human acetylcholinesterase (hAChE) has been reported; however, the inhibition mechanism of hAChE by galantamine is not well understood. Galantamine 143-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-76 33382027-3 2020 The crystal structure of galantamine bound human acetylcholinesterase (hAChE) has been reported; however, the inhibition mechanism of hAChE by galantamine is not well understood. Galantamine 25-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-76 33382027-3 2020 The crystal structure of galantamine bound human acetylcholinesterase (hAChE) has been reported; however, the inhibition mechanism of hAChE by galantamine is not well understood. Galantamine 143-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-139 33382027-3 2020 The crystal structure of galantamine bound human acetylcholinesterase (hAChE) has been reported; however, the inhibition mechanism of hAChE by galantamine is not well understood. Galantamine 25-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-139 33382027-4 2020 A Well-tempered metadynamics (WTMtD) simulation study has been performed with the crystal structure of galantamine bound hAChE. Galantamine 103-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-126 33382027-6 2020 Such proton transfer process is lowered in the presence of galantamine due to the separation of catalytic triad inside the gorge of AChE as observed with WTMtD. Galantamine 59-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 33382027-7 2020 A docking study has been performed to examine the ACh"s binding with the catalytic triad of galantamine bound hAChE. Acetylcholine 50-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-115 33382027-7 2020 A docking study has been performed to examine the ACh"s binding with the catalytic triad of galantamine bound hAChE. Galantamine 92-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-115 33383645-7 2020 In turn, BBB-permeability studies were inconclusive, and conjugation to the CPP led to a considerable loss of Tacrine function as an AChE inhibitor. Tacrine 110-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 33375412-0 2020 First Synthesis of Racemic Trans Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer"s Disease. trans propargylamino-donepezil 27-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 33375412-2 2020 Among the numerous targets which are today validated against AD, acetylcholinesterase (ACh) and Monoamine Oxidase-B (MAO-B) appear as particularly convincing, especially if displayed by a sole agent such as ladostigil, currently in clinical trial in AD. (N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate 207-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 33375412-2 2020 Among the numerous targets which are today validated against AD, acetylcholinesterase (ACh) and Monoamine Oxidase-B (MAO-B) appear as particularly convincing, especially if displayed by a sole agent such as ladostigil, currently in clinical trial in AD. (N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate 207-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-90 33375412-3 2020 Considering these results, we wanted to take benefit of the structural analogy lying in donepezil (DPZ) and rasagiline, two indane derivatives marketed as AChE and MAO-B inhibitors, respectively, and to propose the synthesis and the preliminary in vitro biological characterization of a structural compromise between these two compounds, we called propargylaminodonepezil (PADPZ). Donepezil 88-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 33375412-3 2020 Considering these results, we wanted to take benefit of the structural analogy lying in donepezil (DPZ) and rasagiline, two indane derivatives marketed as AChE and MAO-B inhibitors, respectively, and to propose the synthesis and the preliminary in vitro biological characterization of a structural compromise between these two compounds, we called propargylaminodonepezil (PADPZ). Donepezil 99-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 33375412-3 2020 Considering these results, we wanted to take benefit of the structural analogy lying in donepezil (DPZ) and rasagiline, two indane derivatives marketed as AChE and MAO-B inhibitors, respectively, and to propose the synthesis and the preliminary in vitro biological characterization of a structural compromise between these two compounds, we called propargylaminodonepezil (PADPZ). rasagiline 108-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 33375412-3 2020 Considering these results, we wanted to take benefit of the structural analogy lying in donepezil (DPZ) and rasagiline, two indane derivatives marketed as AChE and MAO-B inhibitors, respectively, and to propose the synthesis and the preliminary in vitro biological characterization of a structural compromise between these two compounds, we called propargylaminodonepezil (PADPZ). indan 124-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 33375412-4 2020 The synthesis of racemic trans PADPZ was achieved and its biological evaluation established its inhibitory activities towards both (h)AChE (IC50 = 0.4 microM) and (h)MAO-B (IC50 = 6.4 microM). trans padpz 25-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 33357230-7 2020 Inhibition of this cancer-cell-intrinsic AChE via pyridostigmine and physostigmine, or administration of acetylcholine (ACh), diminished PCa cell viability and invasion in vitro and in vivo via suppression of pERK signaling, and reduced tumor-associated macrophage (TAM) infiltration and serum pro-inflammatory cytokine levels. Pyridostigmine Bromide 50-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 33357230-7 2020 Inhibition of this cancer-cell-intrinsic AChE via pyridostigmine and physostigmine, or administration of acetylcholine (ACh), diminished PCa cell viability and invasion in vitro and in vivo via suppression of pERK signaling, and reduced tumor-associated macrophage (TAM) infiltration and serum pro-inflammatory cytokine levels. Physostigmine 69-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 33225325-5 2020 AChE can catalyze the hydrolysis of acetylthiocholine (ATCh) to form thiocholine (TCh), which can induce the fluorescence quenching of AuNCs while having no obvious influence on the fluorescence intensity of FL. Acetylthiocholine 36-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 32984993-0 2021 Synthesis and in silico studies of triazene-substituted sulfamerazine derivatives as acetylcholinesterase and carbonic anhydrases inhibitors. Triazenes 35-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 32984993-0 2021 Synthesis and in silico studies of triazene-substituted sulfamerazine derivatives as acetylcholinesterase and carbonic anhydrases inhibitors. Sulfamerazine 56-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 33225325-5 2020 AChE can catalyze the hydrolysis of acetylthiocholine (ATCh) to form thiocholine (TCh), which can induce the fluorescence quenching of AuNCs while having no obvious influence on the fluorescence intensity of FL. Acetylthiocholine 55-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 33225325-5 2020 AChE can catalyze the hydrolysis of acetylthiocholine (ATCh) to form thiocholine (TCh), which can induce the fluorescence quenching of AuNCs while having no obvious influence on the fluorescence intensity of FL. Thiocholine 42-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 33225325-5 2020 AChE can catalyze the hydrolysis of acetylthiocholine (ATCh) to form thiocholine (TCh), which can induce the fluorescence quenching of AuNCs while having no obvious influence on the fluorescence intensity of FL. Thiocholine 56-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 33225325-5 2020 AChE can catalyze the hydrolysis of acetylthiocholine (ATCh) to form thiocholine (TCh), which can induce the fluorescence quenching of AuNCs while having no obvious influence on the fluorescence intensity of FL. Fluorescein 208-210 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 33488256-0 2020 Synthesis and pharmacological effects of novel benzenesulfonamides carrying benzamide moiety as carbonic anhydrase and acetylcholinesterase inhibitors. benzenesulfonamide 47-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 33488256-0 2020 Synthesis and pharmacological effects of novel benzenesulfonamides carrying benzamide moiety as carbonic anhydrase and acetylcholinesterase inhibitors. benzamide 76-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 33488256-6 2020 Secondary sulfonamides showed promising enzyme inhibitory effects on AChE while primary sulfonamide derivative was generally effective on hCA I and hCA II isoenzymes. Sulfonamides 10-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 33488256-6 2020 Secondary sulfonamides showed promising enzyme inhibitory effects on AChE while primary sulfonamide derivative was generally effective on hCA I and hCA II isoenzymes. Sulfonamides 10-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 33218485-4 2020 Acetylcholinesterase was immobilized to fabricate the enzyme reactor Fe3O4@COF-Apt-AChE through the high affinity and specificity with its binding aptamer. ferryl iron 69-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 33137375-0 2020 Novel deoxyvasicinone and tetrahydro-beta-carboline hybrids as inhibitors of acetylcholinesterase and amyloid beta aggregation. 2,3-trimethylene-4-quinazolone 6-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 33218485-4 2020 Acetylcholinesterase was immobilized to fabricate the enzyme reactor Fe3O4@COF-Apt-AChE through the high affinity and specificity with its binding aptamer. ferryl iron 69-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 33137375-0 2020 Novel deoxyvasicinone and tetrahydro-beta-carboline hybrids as inhibitors of acetylcholinesterase and amyloid beta aggregation. tryptoline 26-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 33218485-4 2020 Acetylcholinesterase was immobilized to fabricate the enzyme reactor Fe3O4@COF-Apt-AChE through the high affinity and specificity with its binding aptamer. cof-apt 75-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 33137375-1 2020 A novel series of deoxyvasicinone-tetrahydro-beta-carboline hybrids were synthesized and evaluated as acetylcholinesterase (AChE) and beta-amyloid peptide (Abeta) aggregation inhibitors for the treatment of Alzheimer"s disease. 2,3-trimethylene-4-quinazolone 18-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 33137375-1 2020 A novel series of deoxyvasicinone-tetrahydro-beta-carboline hybrids were synthesized and evaluated as acetylcholinesterase (AChE) and beta-amyloid peptide (Abeta) aggregation inhibitors for the treatment of Alzheimer"s disease. 2,3-trimethylene-4-quinazolone 18-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 33137375-1 2020 A novel series of deoxyvasicinone-tetrahydro-beta-carboline hybrids were synthesized and evaluated as acetylcholinesterase (AChE) and beta-amyloid peptide (Abeta) aggregation inhibitors for the treatment of Alzheimer"s disease. tryptoline 34-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 33137375-1 2020 A novel series of deoxyvasicinone-tetrahydro-beta-carboline hybrids were synthesized and evaluated as acetylcholinesterase (AChE) and beta-amyloid peptide (Abeta) aggregation inhibitors for the treatment of Alzheimer"s disease. tryptoline 34-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 33218485-4 2020 Acetylcholinesterase was immobilized to fabricate the enzyme reactor Fe3O4@COF-Apt-AChE through the high affinity and specificity with its binding aptamer. cof-apt 75-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 33320798-0 2022 Organophosphate pesticide exposure among farm women and children: Status of micronutrients, acetylcholinesterase activity, and oxidative stress. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 33307019-10 2021 The rapid hydrolysis of acetylcholine by acetylcholinesterase generates high local proton concentrations. Acetylcholine 24-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 33058916-7 2020 Donepezil, an acetylcholinesterase inhibitor, improves cognition and global function in patients with Alzheimer"s and Vascular dementia via modulation of acetylcholine receptors and downstream inflammatory response. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 33278027-1 2021 Acetylcholinesterase (AChE, EC 3.1.1.7) plays important roles in cholinergic neurotransmission and has been widely recognized as a biomarker for monitoring pollution by organophosphate (OP) and carbamate pesticides. Organophosphates 169-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 33278027-1 2021 Acetylcholinesterase (AChE, EC 3.1.1.7) plays important roles in cholinergic neurotransmission and has been widely recognized as a biomarker for monitoring pollution by organophosphate (OP) and carbamate pesticides. Organophosphates 169-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 33278027-1 2021 Acetylcholinesterase (AChE, EC 3.1.1.7) plays important roles in cholinergic neurotransmission and has been widely recognized as a biomarker for monitoring pollution by organophosphate (OP) and carbamate pesticides. Carbamates 194-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 33278027-1 2021 Acetylcholinesterase (AChE, EC 3.1.1.7) plays important roles in cholinergic neurotransmission and has been widely recognized as a biomarker for monitoring pollution by organophosphate (OP) and carbamate pesticides. Carbamates 194-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 33278027-2 2021 Dioxin is an emerging environmental AChE disruptor and is a typical persistent organic pollutant with multiple toxic effects on the nervous system. Dioxins 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 33278027-3 2021 Growing evidence has shown that there is a significant link between dioxin exposure and neurodegenerative diseases and neurodevelopmental disorders, most of which involve AChE and cholinergic dysfunctions. Dioxins 68-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 33278027-4 2021 Therefore, an in-depth understanding of the effects of dioxin on AChE and the related mechanisms of action might help to shed light on the molecular bases of dioxin impacts on the nervous system. Dioxins 55-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 33278027-4 2021 Therefore, an in-depth understanding of the effects of dioxin on AChE and the related mechanisms of action might help to shed light on the molecular bases of dioxin impacts on the nervous system. Dioxins 158-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 33278027-5 2021 In the past decade, the effects of dioxins on AChE have been revealed in cultured cells of different origins and in rodent animal models. Dioxins 35-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 33278027-6 2021 Unlike OP and carbamate pesticides, dioxin-induced AChE disturbance is not due to direct inhibition of enzymatic activity; instead, dioxin causes alterations of AChE expression in certain models. Dioxins 36-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 33278027-7 2021 As a widely accepted mechanism for most dioxin effects, the aryl hydrocarbon receptor (AhR)-dependent pathway has become a research focus in studies on the mechanism of action of dioxin-induced AChE dysregulation. Dioxins 179-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 194-198 33278027-8 2021 In this mini-review, the effects of dioxin on AChE and the diverse roles of the AhR pathway in AChE regulation are summarized. Dioxins 36-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 33278027-8 2021 In this mini-review, the effects of dioxin on AChE and the diverse roles of the AhR pathway in AChE regulation are summarized. Dioxins 36-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 32924264-0 2020 Selected 1,3-benzodioxine-containing chalcones as multipotent monoamine oxidase and acetylcholinesterase inhibitors. 1,3-benzodioxine 9-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 32924264-0 2020 Selected 1,3-benzodioxine-containing chalcones as multipotent monoamine oxidase and acetylcholinesterase inhibitors. Chalcones 37-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 32924264-2 2020 The present work describes the syntheses of selected 1,3-benzodioxine-containing chalcones (CD3, CD8 and CD10), and their inhibitory activities against MAO-A, MAO-B, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). 1,3-benzodioxine 53-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-186 32924264-2 2020 The present work describes the syntheses of selected 1,3-benzodioxine-containing chalcones (CD3, CD8 and CD10), and their inhibitory activities against MAO-A, MAO-B, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). 1,3-benzodioxine 53-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-192 32924264-2 2020 The present work describes the syntheses of selected 1,3-benzodioxine-containing chalcones (CD3, CD8 and CD10), and their inhibitory activities against MAO-A, MAO-B, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). Chalcones 81-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-186 32924264-2 2020 The present work describes the syntheses of selected 1,3-benzodioxine-containing chalcones (CD3, CD8 and CD10), and their inhibitory activities against MAO-A, MAO-B, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). Chalcones 81-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-192 33267602-6 2021 Low acetylcholinesterase levels confirmed organophosphate poisoning. Organophosphates 42-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 32815568-3 2020 In addition, the inhibitory effects of the newly synthesized compounds on the activities of hCA and acetylcholinesterase (AChE) were investigated in vitro, using the esterase and acetylcholine iodide method. Acetylcholine 179-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 33037899-7 2020 The oxon analogues were more potent inhibitors of electric eel AChE compared to human AChE. oxon 4-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 33037899-7 2020 The oxon analogues were more potent inhibitors of electric eel AChE compared to human AChE. oxon 4-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 33068814-8 2020 Regarding in vitro results, p2 (IC50 = 16 +- 3.2 muM) and p10 (IC50 = 23.6 +- 4.9 muM) showed significant AChE inhibitory effects. P-2 28-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 33339082-0 2020 Design, synthesis and biological assessment of acridine derivatives containing 1,3,4-thiadiazole moiety as novel selective acetylcholinesterase inhibitors. Acridines 47-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-143 33339082-0 2020 Design, synthesis and biological assessment of acridine derivatives containing 1,3,4-thiadiazole moiety as novel selective acetylcholinesterase inhibitors. 1,3,4-thiadiazole 79-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-143 32721694-0 2020 Effect of chlorination on anti-acetylcholinesterase activity of organophosphorus insecticide solutions and contributions of the parent insecticides and their oxons to the activity. organophosphorus 64-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 32721694-2 2020 For most organophosphorus insecticides, the toxicological endpoint for determining acceptable daily intake levels is inhibition of acetylcholinesterase (AChE). organophosphorus 9-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-151 32721694-2 2020 For most organophosphorus insecticides, the toxicological endpoint for determining acceptable daily intake levels is inhibition of acetylcholinesterase (AChE). organophosphorus 9-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 32721694-3 2020 Like the parent insecticides, oxons also inhibit AChE, so the presence of oxons in drinking water is also evaluated. oxons 30-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 32721694-5 2020 In the present study, we determined whether the anti-AChE activity observed for chlorinated solutions of the organophosphorus insecticides malathion and methidathion could be solely attributed to the parent compounds and their oxons. organophosphorus 109-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 32721694-5 2020 In the present study, we determined whether the anti-AChE activity observed for chlorinated solutions of the organophosphorus insecticides malathion and methidathion could be solely attributed to the parent compounds and their oxons. Malathion 139-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 32721694-5 2020 In the present study, we determined whether the anti-AChE activity observed for chlorinated solutions of the organophosphorus insecticides malathion and methidathion could be solely attributed to the parent compounds and their oxons. methidathion 153-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 32721694-9 2020 For both the malathion-containing solution and the methidathion-containing solution, the calculated anti-AChE activities were almost the same as the observed activities at every chlorination time. Malathion 13-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 32721694-9 2020 For both the malathion-containing solution and the methidathion-containing solution, the calculated anti-AChE activities were almost the same as the observed activities at every chlorination time. methidathion 51-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 32794101-8 2020 Finally, viral-mediated hippocampal expression of human AChE used to lower ACh levels blocked SA-induced elevation of FST immobility. sa 94-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 32949615-2 2020 Harmful effects of OPs on health have been attributed primarily for irreversible inhibition of acetylcholinesterase (AChE) at nerve synapse. Organophosphates 19-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 32949615-2 2020 Harmful effects of OPs on health have been attributed primarily for irreversible inhibition of acetylcholinesterase (AChE) at nerve synapse. Organophosphates 19-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 32949615-3 2020 However, studies have shown that inhibition of AChE alone cannot explain all the maladies encountered in prolonged exposure to OPs. Organophosphates 127-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 32942070-0 2020 Discovery of methoxy-naphthyl linked N-(1-benzylpiperidine) benzamide as a blood-brain permeable dual inhibitor of acetylcholinesterase and butyrylcholinesterase. methoxy-naphthyl 13-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 32942070-0 2020 Discovery of methoxy-naphthyl linked N-(1-benzylpiperidine) benzamide as a blood-brain permeable dual inhibitor of acetylcholinesterase and butyrylcholinesterase. n-(1-benzylpiperidine) benzamide 37-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 32942070-5 2020 Herein, we developed an energy-optimized e-pharmacophore hypothesis AHHPRR from AChE-donepezil complex and screened a set of 15 scaffolds that were designed imaginarily. Donepezil 85-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 32942070-7 2020 A series of pyridinium benzamides were synthesized and screened for cholinesterase inhibition that led to the identification of 7b, a naphthalene containing N-(1-benzylpiperidine) benzamide as a potent dual AChE and BChE inhibitor with IC50 values of 0.176, and 0.47 muM, respectively. pyridinium benzamides 12-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-211 32942070-7 2020 A series of pyridinium benzamides were synthesized and screened for cholinesterase inhibition that led to the identification of 7b, a naphthalene containing N-(1-benzylpiperidine) benzamide as a potent dual AChE and BChE inhibitor with IC50 values of 0.176, and 0.47 muM, respectively. naphthalene 134-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-211 32942070-7 2020 A series of pyridinium benzamides were synthesized and screened for cholinesterase inhibition that led to the identification of 7b, a naphthalene containing N-(1-benzylpiperidine) benzamide as a potent dual AChE and BChE inhibitor with IC50 values of 0.176, and 0.47 muM, respectively. n-(1-benzylpiperidine) benzamide 157-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-211 33145964-0 2020 Interaction of amyloid beta with humanin and acetylcholinesterase is modulated by ATP. Adenosine Triphosphate 82-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 33145964-4 2020 We found that binding of either HN or AChE to Abeta is not affected by heparan sulfate, while ATP, thought to reduce misfolding of Abeta, weakened interactions between AChE and Abeta but strengthened those between Abeta and HN. Adenosine Triphosphate 94-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-172 33145964-5 2020 Using media from either A549 or H1299 lung cancer cells, we observed that more HN was bound to Abeta upon addition of ATP, while levels of AChE in a complex with Abeta were decreased by ATP addition to A549 cell media. Adenosine Triphosphate 186-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 33145964-6 2020 Exogenous addition of ATP to either A549 or H1299 cell media increased interactions of endogenous HN with Abeta to a comparable extent despite differences in AChE expression in the two cell lines, and this was correlated with decreased binding of exogenously added HN to Abeta. Adenosine Triphosphate 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 32882280-7 2020 AChE was immobilized onto this prepared nano-interface (ZnONFs/rGO/Au) through chitosan and glutaraldehyde cross-linking. Chitosan 79-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 31760822-2 2020 The BF framework aims to endow the conjugate molecules with ability for inhibition of AChE (bimodal way) and of amyloid-beta peptide aggregation, besides providing metal (Fe, Cu) chelating ability and concomitant extra anti-oxidant activity, for the hybrids with hydroxyl substitution. Copper 175-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 31760822-2 2020 The BF framework aims to endow the conjugate molecules with ability for inhibition of AChE (bimodal way) and of amyloid-beta peptide aggregation, besides providing metal (Fe, Cu) chelating ability and concomitant extra anti-oxidant activity, for the hybrids with hydroxyl substitution. Hydroxyl Radical 263-271 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 31760822-3 2020 The new TAC-BF conjugates showed very good activity for AChE inhibition (sub-micromolar range) and good capacity for the inhibition of self- and Cu-mediated Abeta aggregation, with dependence on the linker size and substituent groups of each main moiety. tac-bf 8-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 31899981-3 2020 It was previously shown for trans-4/5-arylethenyloxazole compounds to have moderate AChE and BChE inhibitory properties. trans-4/5-arylethenyloxazole 28-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 31899981-8 2020 All of the compounds exhibited binding preference for BChE over AChE, especially for trans-amino-4-/5-arylethenyl-oxazole derivatives which inhibited BChE potently (IC50 in microM range) and AChE poorly (IC50>>100 microM). trans-amino-4-/5-arylethenyl-oxazole 85-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 31899981-8 2020 All of the compounds exhibited binding preference for BChE over AChE, especially for trans-amino-4-/5-arylethenyl-oxazole derivatives which inhibited BChE potently (IC50 in microM range) and AChE poorly (IC50>>100 microM). trans-amino-4-/5-arylethenyl-oxazole 85-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 191-195 31899981-9 2020 Therefore, due to the selectivity of all of the tested compounds for binding to BChE, these compounds could be applied for further development of cholinesterase selective inhibitors.HIGHLIGHTSSeries of oxazole benzylamines were designed and synthesisedThe tested compounds showed binding selectivity for BChENaphthoxazoles were more potent AChE inhibitors. oxazole benzylamines 202-222 acetylcholinesterase (Cartwright blood group) Homo sapiens 340-344 31899985-0 2020 Sulphonamides incorporating 1,3,5-triazine structural motifs show antioxidant, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory profile. Sulfonamides 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 31899985-0 2020 Sulphonamides incorporating 1,3,5-triazine structural motifs show antioxidant, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory profile. 1,3,5-TRIAZINE 28-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 31910701-0 2020 Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators. 1-methyl-1,6-dihydropyridine-2-carbaldoxime 55-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 31910701-3 2020 The AChE reactivation for all used organophosphates was found negligible if compared to the reactivation ability of obidoxime. Organophosphates 35-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 32183602-3 2020 3-Arylbenzofuranone compounds exhibit good antioxidant activity as well as selective acetylcholinesterase inhibitory activity. 3-arylbenzofuranone 0-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 32401067-0 2020 Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action. calix[4]azacrown substituted sulphonamides 13-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 32401067-4 2020 The calix[4]azacrown substituted sulphonamide Schiff bases were also investigated as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and tyrosinase enzymes, associated with several diseases such as Alzheimer, Parkinson, and pigmentation disorders. [4]azacrown substituted sulphonamide 9-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 32401067-4 2020 The calix[4]azacrown substituted sulphonamide Schiff bases were also investigated as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and tyrosinase enzymes, associated with several diseases such as Alzheimer, Parkinson, and pigmentation disorders. [4]azacrown substituted sulphonamide 9-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 32401067-5 2020 The new sulphonamides showed low to moderate inhibition against hCAs, AChE, BChE, and tyrosinase enzymes. Sulfonamides 8-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 32779503-2 2020 Edaravone is a potent antioxidant with significant neuroprotective effects and N-benzyl pyridinium has previously exhibited positive results as part of a dual-site binding, peripheral anionic site (PAS) and catalytic anionic site (CAS), acetylcholinesterase (AChE) inhibitor. Edaravone 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 237-257 32779503-2 2020 Edaravone is a potent antioxidant with significant neuroprotective effects and N-benzyl pyridinium has previously exhibited positive results as part of a dual-site binding, peripheral anionic site (PAS) and catalytic anionic site (CAS), acetylcholinesterase (AChE) inhibitor. Edaravone 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 259-263 32779503-2 2020 Edaravone is a potent antioxidant with significant neuroprotective effects and N-benzyl pyridinium has previously exhibited positive results as part of a dual-site binding, peripheral anionic site (PAS) and catalytic anionic site (CAS), acetylcholinesterase (AChE) inhibitor. n-benzyl pyridinium 79-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 237-257 32779503-2 2020 Edaravone is a potent antioxidant with significant neuroprotective effects and N-benzyl pyridinium has previously exhibited positive results as part of a dual-site binding, peripheral anionic site (PAS) and catalytic anionic site (CAS), acetylcholinesterase (AChE) inhibitor. n-benzyl pyridinium 79-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 259-263 32779503-3 2020 The designed edaravone-N-benzyl pyridinium hybrid compounds were docked within the AChE active site. edaravone-n-benzyl pyridinium 13-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 31694418-0 2020 Design, synthesis and evaluation of quinolinone derivatives containing dithiocarbamate moiety as multifunctional AChE inhibitors for the treatment of Alzheimer"s disease. Quinolones 36-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 31694418-0 2020 Design, synthesis and evaluation of quinolinone derivatives containing dithiocarbamate moiety as multifunctional AChE inhibitors for the treatment of Alzheimer"s disease. Dithiocarbamate 71-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 31694418-1 2020 A series of novel quinolinone derivatives bearing dithiocarbamate moiety were designed and synthesised as multifunctional AChE inhibitors for the treatment of AD. Quinolones 18-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 31694418-1 2020 A series of novel quinolinone derivatives bearing dithiocarbamate moiety were designed and synthesised as multifunctional AChE inhibitors for the treatment of AD. Dithiocarbamate 50-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 32814088-2 2020 Their broad-spectrum insecticidal effectiveness is accounted for by the irreversible inhibition of acetylcholinesterase (AChE), the enzyme that catalyzes acetylcholine (ACh) hydrolysis, in the nervous system of insects. Acetylcholine 99-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 32814088-2 2020 Their broad-spectrum insecticidal effectiveness is accounted for by the irreversible inhibition of acetylcholinesterase (AChE), the enzyme that catalyzes acetylcholine (ACh) hydrolysis, in the nervous system of insects. Acetylcholine 121-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 33327436-7 2020 Both cyclanoline and fangchinoline showed acetylcholinesterase (AChE) inhibitory activity, demonstrating noncompetitive enzyme inhibition. cyclanoline 5-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 33327436-7 2020 Both cyclanoline and fangchinoline showed acetylcholinesterase (AChE) inhibitory activity, demonstrating noncompetitive enzyme inhibition. cyclanoline 5-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 33327436-7 2020 Both cyclanoline and fangchinoline showed acetylcholinesterase (AChE) inhibitory activity, demonstrating noncompetitive enzyme inhibition. fangchinoline 21-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 33327436-7 2020 Both cyclanoline and fangchinoline showed acetylcholinesterase (AChE) inhibitory activity, demonstrating noncompetitive enzyme inhibition. fangchinoline 21-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 33327436-10 2020 The drug combination of fangchinoline-huperzine A or donepezil synergistically inhibited AChE, having a combination index (CI) < 1 at Fa = 0.5. fangchinoline 24-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 33327436-10 2020 The drug combination of fangchinoline-huperzine A or donepezil synergistically inhibited AChE, having a combination index (CI) < 1 at Fa = 0.5. huperzine A 38-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 33327436-10 2020 The drug combination of fangchinoline-huperzine A or donepezil synergistically inhibited AChE, having a combination index (CI) < 1 at Fa = 0.5. Donepezil 53-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 33327436-11 2020 Furthermore, the molecular docking results showed that fangchinoline bound with AChE residues in the peripheral anionic site, and cyclanoline bound with AChE residues in the peripheral anionic site, anionic site, and catalytic site. fangchinoline 55-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 33327436-11 2020 Furthermore, the molecular docking results showed that fangchinoline bound with AChE residues in the peripheral anionic site, and cyclanoline bound with AChE residues in the peripheral anionic site, anionic site, and catalytic site. cyclanoline 130-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 33327436-13 2020 The results support that fangchinoline and cyclanoline, alkaloids derived from STR, could account for the anti-AChE function of STR. fangchinoline 25-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 33327436-13 2020 The results support that fangchinoline and cyclanoline, alkaloids derived from STR, could account for the anti-AChE function of STR. cyclanoline 43-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 33184595-3 2020 The present study aims to screen the inhibitory activity of newly synthesized and existing novel 4-methylthiocoumarin derivative against acetylcholinesterase, butyrylcholinesterase, BACE1, beta-amyloid aggregation and oxidative stress involved in the AD pathogenesis. 4-methylchromene-2-thione 97-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 33184595-6 2020 C3 and C7 (thiocoumarin derivatives) were found to be the most potent inhibitors of acetylcholinesterase (IC50-5.63 microM) and butyrylcholinesterase (IC50-3.40 microM) using Ellman"s assays. THIOCOUMARIN 11-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 32991975-9 2020 We also found that bulbocodin D had a good inhibitory effect on AChE and GSK3beta. Bulbocodin D 19-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 32956608-12 2020 Molecular docking showed that stigmasterol, aposcopolamine and inermin can closely bind three targets (ACHE, ADRA2A and CHRM2). Stigmasterol 30-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 32956608-12 2020 Molecular docking showed that stigmasterol, aposcopolamine and inermin can closely bind three targets (ACHE, ADRA2A and CHRM2). Apohyoscine 44-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 32956608-12 2020 Molecular docking showed that stigmasterol, aposcopolamine and inermin can closely bind three targets (ACHE, ADRA2A and CHRM2). inermin 63-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 33260981-1 2020 Kinetic studies and molecular modeling of human acetylcholinesterase (AChE) inhibition by a fluorinated acetophenone derivative, 1-(3-tert-butylphenyl)-2,2,2-trifluoroethanone (TFK), were performed. acetophenone 104-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 33260981-1 2020 Kinetic studies and molecular modeling of human acetylcholinesterase (AChE) inhibition by a fluorinated acetophenone derivative, 1-(3-tert-butylphenyl)-2,2,2-trifluoroethanone (TFK), were performed. acetophenone 104-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 33260981-1 2020 Kinetic studies and molecular modeling of human acetylcholinesterase (AChE) inhibition by a fluorinated acetophenone derivative, 1-(3-tert-butylphenyl)-2,2,2-trifluoroethanone (TFK), were performed. CHEMBL89354 129-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 33260981-1 2020 Kinetic studies and molecular modeling of human acetylcholinesterase (AChE) inhibition by a fluorinated acetophenone derivative, 1-(3-tert-butylphenyl)-2,2,2-trifluoroethanone (TFK), were performed. CHEMBL89354 129-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 33260981-14 2020 Thus, this fluoroalkylketone intended for neuroimaging, could be of interest in palliative therapy of Alzheimer"s disease and protection of central AChE against organophosphorus compounds. fluoroalkylketone 11-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 33260981-14 2020 Thus, this fluoroalkylketone intended for neuroimaging, could be of interest in palliative therapy of Alzheimer"s disease and protection of central AChE against organophosphorus compounds. organophosphorus 161-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 33112607-4 2020 Recent studies have reported that temephos-oxidized derivatives cause AChE inhibition. Temefos 34-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 33306055-11 2020 Conclusions: The chloroform leaf extract of C carandas was found to contain constituents that have affinities for the 2 targets tested; that is, amyloid beta and acetylcholinesterase. Chloroform 17-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-182 32931834-0 2020 Thiazolyl-pyrazoline derivatives: In vitro and in silico evaluation as potential acetylcholinesterase and carbonic anhydrase inhibitors. thiazolyl-pyrazoline 0-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 32931834-5 2020 In an attempt to identify potent AChE and hCA inhibitors, new thiazolyl-pyrazolines (3a-k) were designed based on the molecular hybridization of thiazole and pyrazoline scaffolds. thiazolyl-pyrazolines 62-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 32931834-5 2020 In an attempt to identify potent AChE and hCA inhibitors, new thiazolyl-pyrazolines (3a-k) were designed based on the molecular hybridization of thiazole and pyrazoline scaffolds. Thiazoles 145-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 32931834-5 2020 In an attempt to identify potent AChE and hCA inhibitors, new thiazolyl-pyrazolines (3a-k) were designed based on the molecular hybridization of thiazole and pyrazoline scaffolds. pyrazoline 72-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 33047950-1 2020 Fourteen (hetero-)(arylidene)arylhydrazide derivatives (ABH1-ABH14) were synthesized, and their inhibitory activities against monoamine oxidases (MAOs) and acetylcholinesterase (AChE) were evaluated. (hetero-)(arylidene)arylhydrazide 9-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-176 33170091-6 2022 The computational virtual screening (VS) led to the identification of thiazolidinedione (TZD, antidiabetic) and aminoquinoline (antimalarial) class of drugs as acetylcholinesterase (AChE) inhibitors. 2,4-thiazolidinedione 70-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-180 33170091-6 2022 The computational virtual screening (VS) led to the identification of thiazolidinedione (TZD, antidiabetic) and aminoquinoline (antimalarial) class of drugs as acetylcholinesterase (AChE) inhibitors. 2,4-thiazolidinedione 70-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-186 33170091-6 2022 The computational virtual screening (VS) led to the identification of thiazolidinedione (TZD, antidiabetic) and aminoquinoline (antimalarial) class of drugs as acetylcholinesterase (AChE) inhibitors. 2,4-thiazolidinedione 89-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-180 33170091-6 2022 The computational virtual screening (VS) led to the identification of thiazolidinedione (TZD, antidiabetic) and aminoquinoline (antimalarial) class of drugs as acetylcholinesterase (AChE) inhibitors. 2,4-thiazolidinedione 89-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-186 33170091-6 2022 The computational virtual screening (VS) led to the identification of thiazolidinedione (TZD, antidiabetic) and aminoquinoline (antimalarial) class of drugs as acetylcholinesterase (AChE) inhibitors. Aminoquinolines 112-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-180 33170091-6 2022 The computational virtual screening (VS) led to the identification of thiazolidinedione (TZD, antidiabetic) and aminoquinoline (antimalarial) class of drugs as acetylcholinesterase (AChE) inhibitors. Aminoquinolines 112-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-186 33170091-7 2022 Intriguingly, rosiglitazone (RGZ) and hydroxychloroquine (HCQ) were found to be mild-to-moderate inhibitors of hAChE (human acetylcholinesterase) in our enzyme inhibition studies which are complementary to our computational studies. Rosiglitazone 14-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-116 33170091-7 2022 Intriguingly, rosiglitazone (RGZ) and hydroxychloroquine (HCQ) were found to be mild-to-moderate inhibitors of hAChE (human acetylcholinesterase) in our enzyme inhibition studies which are complementary to our computational studies. Rosiglitazone 14-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 33170091-7 2022 Intriguingly, rosiglitazone (RGZ) and hydroxychloroquine (HCQ) were found to be mild-to-moderate inhibitors of hAChE (human acetylcholinesterase) in our enzyme inhibition studies which are complementary to our computational studies. Rosiglitazone 29-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-116 33170091-7 2022 Intriguingly, rosiglitazone (RGZ) and hydroxychloroquine (HCQ) were found to be mild-to-moderate inhibitors of hAChE (human acetylcholinesterase) in our enzyme inhibition studies which are complementary to our computational studies. Rosiglitazone 29-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 33170091-7 2022 Intriguingly, rosiglitazone (RGZ) and hydroxychloroquine (HCQ) were found to be mild-to-moderate inhibitors of hAChE (human acetylcholinesterase) in our enzyme inhibition studies which are complementary to our computational studies. Hydroxychloroquine 38-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-116 33047950-1 2020 Fourteen (hetero-)(arylidene)arylhydrazide derivatives (ABH1-ABH14) were synthesized, and their inhibitory activities against monoamine oxidases (MAOs) and acetylcholinesterase (AChE) were evaluated. (hetero-)(arylidene)arylhydrazide 9-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-182 33170091-7 2022 Intriguingly, rosiglitazone (RGZ) and hydroxychloroquine (HCQ) were found to be mild-to-moderate inhibitors of hAChE (human acetylcholinesterase) in our enzyme inhibition studies which are complementary to our computational studies. Hydroxychloroquine 38-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 33170091-7 2022 Intriguingly, rosiglitazone (RGZ) and hydroxychloroquine (HCQ) were found to be mild-to-moderate inhibitors of hAChE (human acetylcholinesterase) in our enzyme inhibition studies which are complementary to our computational studies. Hydroxychloroquine 58-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-116 33170091-7 2022 Intriguingly, rosiglitazone (RGZ) and hydroxychloroquine (HCQ) were found to be mild-to-moderate inhibitors of hAChE (human acetylcholinesterase) in our enzyme inhibition studies which are complementary to our computational studies. Hydroxychloroquine 58-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 33170091-8 2022 On the basis of our computational and experimental studies, it can be suggested that the beneficial effect of RGZ and HCQ in AD patients reported in the literature may partly be due to their AChE inhibitory property. Rosiglitazone 110-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 191-195 33170091-8 2022 On the basis of our computational and experimental studies, it can be suggested that the beneficial effect of RGZ and HCQ in AD patients reported in the literature may partly be due to their AChE inhibitory property. Hydroxychloroquine 118-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 191-195 33170091-9 2022 The VS also led to the identification of antifungal drugs miconazole and oxiconazole as potential AChE inhibitors. Miconazole 58-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 32716578-4 2020 Dialkylation of alpha-mangostin produced AChE selective inhibitors that formed hydrophobic interactions at the active site of AChE. mangostin 16-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 33170091-9 2022 The VS also led to the identification of antifungal drugs miconazole and oxiconazole as potential AChE inhibitors. oxiconazole 73-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 32716578-4 2020 Dialkylation of alpha-mangostin produced AChE selective inhibitors that formed hydrophobic interactions at the active site of AChE. mangostin 16-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 32716578-7 2020 Taken together, modification of the hydroxyl groups of alpha-mangostin at positions C-3 and C-6 greatly influenced its BChE inhibitory and cytotoxic but not its AChE inhibitory activities. mangostin 55-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-165 32955256-2 2020 We report herein a new donepezil-like natural compound derivative (D1) as a convincing AChE inhibitor. Donepezil 23-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 33049656-5 2020 We measured blood acetylcholinesterase (AChE) activity using the acetylcholine analog acetylthiocholine. Acetylcholine 18-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 33049656-5 2020 We measured blood acetylcholinesterase (AChE) activity using the acetylcholine analog acetylthiocholine. Acetylthiocholine 86-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 33049656-5 2020 We measured blood acetylcholinesterase (AChE) activity using the acetylcholine analog acetylthiocholine. Acetylthiocholine 86-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 31820491-2 2020 In the present study, pure DDN (2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone) was examined, for the first time, for its dual potential as inhibitor of acetylcholinesterase (AChE) and Abeta42 aggregation. 2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone 27-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 31820491-2 2020 In the present study, pure DDN (2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone) was examined, for the first time, for its dual potential as inhibitor of acetylcholinesterase (AChE) and Abeta42 aggregation. 2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone 27-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 31820491-2 2020 In the present study, pure DDN (2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone) was examined, for the first time, for its dual potential as inhibitor of acetylcholinesterase (AChE) and Abeta42 aggregation. 2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone 32-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 31820491-2 2020 In the present study, pure DDN (2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone) was examined, for the first time, for its dual potential as inhibitor of acetylcholinesterase (AChE) and Abeta42 aggregation. 2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone 32-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 31820491-7 2020 Moreover, results showed that DDN inhibited AChE (IC50 = 14.5 microM). 2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone 30-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 31820491-8 2020 To better understand the interactions between DDN and AChE, molecular docking was performed. 2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone 46-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 31820491-10 2020 Several residues involved in AChE hydrophobic interactions were similarly implicated in binding of this domain to DDN (ASP74, THR83 and TYR124). 2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone 114-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 31820491-10 2020 Several residues involved in AChE hydrophobic interactions were similarly implicated in binding of this domain to DDN (ASP74, THR83 and TYR124). 4-hydroxyphenethylamino-3-(2-allyl)phenoxypropan-2-ol 136-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 32048433-3 2020 In the present study, a series of aporphinoid alkaloids were tested as potential acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors in vitro . Alkaloids 34-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 32048433-3 2020 In the present study, a series of aporphinoid alkaloids were tested as potential acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors in vitro . Alkaloids 34-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 32048433-7 2020 Laurotetatine clorhydrate ( 13 ) selectively inhibit AChE over BChE. laurotetatine clorhydrate 0-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 32048433-10 2020 These studies reveal that the benzodioxole moiety exhibits strong interactions due to hydrogen bonds that form with the Glu201 (AChE) and Tyr440 (BChE) residues, which is reflected in the IC 50 values. Benzodioxoles 30-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 32048433-10 2020 These studies reveal that the benzodioxole moiety exhibits strong interactions due to hydrogen bonds that form with the Glu201 (AChE) and Tyr440 (BChE) residues, which is reflected in the IC 50 values. Hydrogen 86-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 33040867-2 2020 Acetylcholinesterase inhibitors act by increasing the amount of acetylcholine in the neuromuscular junction, resulting in flaccid paralysis. Acetylcholine 64-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 33038610-1 2020 Acetylcholinesterase (AChE) hydrolyses acetylcholine to choline and acetate, playing an important role in terminating the neurotransmission in brain and muscle. Acetylcholine 39-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 33038610-1 2020 Acetylcholinesterase (AChE) hydrolyses acetylcholine to choline and acetate, playing an important role in terminating the neurotransmission in brain and muscle. Acetylcholine 39-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 33038610-1 2020 Acetylcholinesterase (AChE) hydrolyses acetylcholine to choline and acetate, playing an important role in terminating the neurotransmission in brain and muscle. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 33038610-1 2020 Acetylcholinesterase (AChE) hydrolyses acetylcholine to choline and acetate, playing an important role in terminating the neurotransmission in brain and muscle. Acetates 68-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 33038610-1 2020 Acetylcholinesterase (AChE) hydrolyses acetylcholine to choline and acetate, playing an important role in terminating the neurotransmission in brain and muscle. Acetates 68-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 33038610-6 2020 The light-mediated AChE expression was triggered by Ca2+, supported by an induction of Ca2+ ionophore A23187 and a blockage by Ca2+ chelator BAPTA-AM. Calcimycin 102-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 33038610-6 2020 The light-mediated AChE expression was triggered by Ca2+, supported by an induction of Ca2+ ionophore A23187 and a blockage by Ca2+ chelator BAPTA-AM. 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 141-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 32645360-0 2020 Glycosylated-imidazole aldoximes as reactivators of pesticides inhibited AChE: Synthesis and in-vitro reactivation study. glycosylated-imidazole aldoximes 0-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 32645360-6 2020 These compounds were evaluated for their in-vitro reactivation ability against pesticide (paraoxon-ethyl and paraoxon-methyl) inhibited-AChE and compared with standards antidote AChE reactivators pralidoxime and obidoxime. paraoxon-ethyl and paraoxon-methyl 90-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 32645360-6 2020 These compounds were evaluated for their in-vitro reactivation ability against pesticide (paraoxon-ethyl and paraoxon-methyl) inhibited-AChE and compared with standards antidote AChE reactivators pralidoxime and obidoxime. pralidoxime 196-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-182 32702607-3 2020 In the face of such threats, a more effective antidote against organophosphonate acetylcholinesterase (AChE) inhibitors is needed, one that can freely penetrate into the central nervous system (CNS) through the blood-brain barrier (BBB). Organophosphonates 63-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 32702607-3 2020 In the face of such threats, a more effective antidote against organophosphonate acetylcholinesterase (AChE) inhibitors is needed, one that can freely penetrate into the central nervous system (CNS) through the blood-brain barrier (BBB). Organophosphonates 63-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 31396774-0 2020 Synthesis and biological evaluation of 1,2,4-triazolidine-3-thiones as potent acetylcholinesterase inhibitors: in vitro and in silico analysis through kinetics, chemoinformatics and computational approaches. 1,2,4-triazolidine-3-thiones 39-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 31396774-4 2020 Pleasingly, synthesized compounds show noteworthy acetylcholinesterase (AChE) inhibitory activity with much lower IC50 values 0.0269 +- 0.0021-1.1725 +- 0.0112 muM than standard Neostigmine methylsulphate. Neostigmine 178-204 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 31396774-4 2020 Pleasingly, synthesized compounds show noteworthy acetylcholinesterase (AChE) inhibitory activity with much lower IC50 values 0.0269 +- 0.0021-1.1725 +- 0.0112 muM than standard Neostigmine methylsulphate. Neostigmine 178-204 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 31396774-7 2020 Therefore, overall present study illustrates synthesis of some new 1,2,4-triazolidines-3-thiones which can serve as a template for drug designing such as AChE inhibitors. 1,2,4-triazolidines-3-thiones 67-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-158 32887168-3 2020 Specifically, according to the subtle differences structural features and substrate preference between BChE and its sister enzyme AChE, CyClCP was constructed by introducing chlorine atom at the ortho-position of the phenolic hydroxyl in the previous reported probe (CyCP). Chlorine 174-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 32898602-9 2020 An increase in reactivation of POX-inhibited human brain acetylcholinesterase up to 36.08 +- 4.3% after intravenous administration of 2-PAM-DSPE-PEG2000-SLNs (dose of 2-PAM is 5 mg/kg) was achieved. pralidoxime 134-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 32898602-9 2020 An increase in reactivation of POX-inhibited human brain acetylcholinesterase up to 36.08 +- 4.3% after intravenous administration of 2-PAM-DSPE-PEG2000-SLNs (dose of 2-PAM is 5 mg/kg) was achieved. 1,2-distearoylphosphatidylethanolamine 140-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 32898602-9 2020 An increase in reactivation of POX-inhibited human brain acetylcholinesterase up to 36.08 +- 4.3% after intravenous administration of 2-PAM-DSPE-PEG2000-SLNs (dose of 2-PAM is 5 mg/kg) was achieved. polyethylene glycol 2000 145-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 32955256-6 2020 While most of the noncholinergic functions of donepezil associated with the PAS of AChE were gradually lost at higher concentrations, D1 was more functional at similar doses. Donepezil 46-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 33105595-1 2020 A library of amine, oxime, ether, epoxy and acyl derivatives of the benzobicyclo[3.2.1]octene were synthesized and evaluated as inhibitors of both human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). benzobicyclo[3.2.1]octene 68-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-173 33105595-1 2020 A library of amine, oxime, ether, epoxy and acyl derivatives of the benzobicyclo[3.2.1]octene were synthesized and evaluated as inhibitors of both human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). benzobicyclo[3.2.1]octene 68-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 175-179 33105595-3 2020 Structural adjustment for AChE seems to have been achieved by acylation, and the furan ring opening of furo-benzobicyclo[3.2.1]octadiene results for compound 51 with the highest AChE affinity (IC50 = 8.3 microM). furan 81-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-182 33105595-3 2020 Structural adjustment for AChE seems to have been achieved by acylation, and the furan ring opening of furo-benzobicyclo[3.2.1]octadiene results for compound 51 with the highest AChE affinity (IC50 = 8.3 microM). furo-benzobicyclo[3.2.1]octadiene 103-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-182 33075241-5 2020 IC50 values narcissoside, as 11.54 nM for AChE and 65.58 nM for alpha-glucosidase were calculated with % Activity-[Inhibitory] graphs. narcissin flavonol 12-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 33075241-5 2020 IC50 values narcissoside, as 11.54 nM for AChE and 65.58 nM for alpha-glucosidase were calculated with % Activity-[Inhibitory] graphs. Arsenic 26-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 33081037-6 2020 1-([1,1"-biphenyl]-4-yl)-4-(piperidin-1-yl)butan-1-one (12) performed as the best compound and was further investigated for acetylcholinesterase (AchE) inhibitor activity and determination of antioxidant activity mediated by aquaporins (AQPs). 1-([1,1"-biphenyl]-4-yl)-4-(piperidin-1-yl)butan-1-one 0-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 32739347-0 2020 Sensitive and reversible perylene derivative-based fluorescent probe for acetylcholinesterase activity monitoring and its inhibitor. Perylene 25-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 32739347-1 2020 A reversible fluorescence probe for acetylcholinesterase activity detection was developed based on water soluble perylene derivative, N,N"-di(2-aspartic acid)-perylene-3,4,9,10-tetracarboxylic diimide (PASP). Water 99-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 32739347-1 2020 A reversible fluorescence probe for acetylcholinesterase activity detection was developed based on water soluble perylene derivative, N,N"-di(2-aspartic acid)-perylene-3,4,9,10-tetracarboxylic diimide (PASP). Perylene 113-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 32739347-1 2020 A reversible fluorescence probe for acetylcholinesterase activity detection was developed based on water soluble perylene derivative, N,N"-di(2-aspartic acid)-perylene-3,4,9,10-tetracarboxylic diimide (PASP). , n,n"-di(2-aspartic acid)-perylene-3,4,9,10-tetracarboxylic diimide 132-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 32739347-1 2020 A reversible fluorescence probe for acetylcholinesterase activity detection was developed based on water soluble perylene derivative, N,N"-di(2-aspartic acid)-perylene-3,4,9,10-tetracarboxylic diimide (PASP). pasp 202-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 32739347-3 2020 Acetylcholinesterase (AChE) is well known to catalyze the hydrolysis of acetylcholine (ATCh) to produce thiocholine, whose affinity is strong enough to capture Cu2+ by thiol (-SH) group from the complex PASP-Cu, resulting in the fluorescence signal of PASP recovers up to 90%. Acetylcholine 72-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32739347-3 2020 Acetylcholinesterase (AChE) is well known to catalyze the hydrolysis of acetylcholine (ATCh) to produce thiocholine, whose affinity is strong enough to capture Cu2+ by thiol (-SH) group from the complex PASP-Cu, resulting in the fluorescence signal of PASP recovers up to 90%. Acetylcholine 72-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 32739347-3 2020 Acetylcholinesterase (AChE) is well known to catalyze the hydrolysis of acetylcholine (ATCh) to produce thiocholine, whose affinity is strong enough to capture Cu2+ by thiol (-SH) group from the complex PASP-Cu, resulting in the fluorescence signal of PASP recovers up to 90%. Acetylcholine 87-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32739347-3 2020 Acetylcholinesterase (AChE) is well known to catalyze the hydrolysis of acetylcholine (ATCh) to produce thiocholine, whose affinity is strong enough to capture Cu2+ by thiol (-SH) group from the complex PASP-Cu, resulting in the fluorescence signal of PASP recovers up to 90%. Acetylcholine 87-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 32739347-3 2020 Acetylcholinesterase (AChE) is well known to catalyze the hydrolysis of acetylcholine (ATCh) to produce thiocholine, whose affinity is strong enough to capture Cu2+ by thiol (-SH) group from the complex PASP-Cu, resulting in the fluorescence signal of PASP recovers up to 90%. Thiocholine 104-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32739347-3 2020 Acetylcholinesterase (AChE) is well known to catalyze the hydrolysis of acetylcholine (ATCh) to produce thiocholine, whose affinity is strong enough to capture Cu2+ by thiol (-SH) group from the complex PASP-Cu, resulting in the fluorescence signal of PASP recovers up to 90%. Thiocholine 104-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 32739347-3 2020 Acetylcholinesterase (AChE) is well known to catalyze the hydrolysis of acetylcholine (ATCh) to produce thiocholine, whose affinity is strong enough to capture Cu2+ by thiol (-SH) group from the complex PASP-Cu, resulting in the fluorescence signal of PASP recovers up to 90%. cupric ion 160-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32739347-3 2020 Acetylcholinesterase (AChE) is well known to catalyze the hydrolysis of acetylcholine (ATCh) to produce thiocholine, whose affinity is strong enough to capture Cu2+ by thiol (-SH) group from the complex PASP-Cu, resulting in the fluorescence signal of PASP recovers up to 90%. cupric ion 160-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 32739347-3 2020 Acetylcholinesterase (AChE) is well known to catalyze the hydrolysis of acetylcholine (ATCh) to produce thiocholine, whose affinity is strong enough to capture Cu2+ by thiol (-SH) group from the complex PASP-Cu, resulting in the fluorescence signal of PASP recovers up to 90%. Sulfhydryl Compounds 168-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32739347-3 2020 Acetylcholinesterase (AChE) is well known to catalyze the hydrolysis of acetylcholine (ATCh) to produce thiocholine, whose affinity is strong enough to capture Cu2+ by thiol (-SH) group from the complex PASP-Cu, resulting in the fluorescence signal of PASP recovers up to 90%. Sulfhydryl Compounds 168-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 32739347-3 2020 Acetylcholinesterase (AChE) is well known to catalyze the hydrolysis of acetylcholine (ATCh) to produce thiocholine, whose affinity is strong enough to capture Cu2+ by thiol (-SH) group from the complex PASP-Cu, resulting in the fluorescence signal of PASP recovers up to 90%. pasp 203-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32739347-3 2020 Acetylcholinesterase (AChE) is well known to catalyze the hydrolysis of acetylcholine (ATCh) to produce thiocholine, whose affinity is strong enough to capture Cu2+ by thiol (-SH) group from the complex PASP-Cu, resulting in the fluorescence signal of PASP recovers up to 90%. pasp 203-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 32739347-3 2020 Acetylcholinesterase (AChE) is well known to catalyze the hydrolysis of acetylcholine (ATCh) to produce thiocholine, whose affinity is strong enough to capture Cu2+ by thiol (-SH) group from the complex PASP-Cu, resulting in the fluorescence signal of PASP recovers up to 90%. Copper 160-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32739347-3 2020 Acetylcholinesterase (AChE) is well known to catalyze the hydrolysis of acetylcholine (ATCh) to produce thiocholine, whose affinity is strong enough to capture Cu2+ by thiol (-SH) group from the complex PASP-Cu, resulting in the fluorescence signal of PASP recovers up to 90%. Copper 160-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 32781220-0 2020 New coumarin-benzotriazole based hybrid molecules as inhibitors of acetylcholinesterase and amyloid aggregation. coumarin 4-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 32781220-0 2020 New coumarin-benzotriazole based hybrid molecules as inhibitors of acetylcholinesterase and amyloid aggregation. benzotriazole 13-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 32781220-2 2020 Among the synthesized compounds 13b showed most potent acetylcholinesterase (AChE) inhibition (IC50 = 0.059 muMu) with mixed type inhibition scenario. CHEMBL3741121 32-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 32781220-2 2020 Among the synthesized compounds 13b showed most potent acetylcholinesterase (AChE) inhibition (IC50 = 0.059 muMu) with mixed type inhibition scenario. CHEMBL3741121 32-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 32781220-4 2020 Hybrids obtained from 4-hydroxycoumarin and 1-benzotriazole were most potent AChE inhibitors. 4-hydroxycoumarin 22-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 32781220-4 2020 Hybrids obtained from 4-hydroxycoumarin and 1-benzotriazole were most potent AChE inhibitors. 1-benzotriazole 44-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 32781220-6 2020 13b (most potent AChE inhibitor) also showed copper-induced Abeta1-42 aggregation inhibition (34.26 % at 50 muMu) and chelating properties for metal ions (Cu2+, Fe2+, and Zn2+) involved in AD pathogenesis along with DNA protective potential against degenerative actions of OH radicals. CHEMBL3741121 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 32781220-6 2020 13b (most potent AChE inhibitor) also showed copper-induced Abeta1-42 aggregation inhibition (34.26 % at 50 muMu) and chelating properties for metal ions (Cu2+, Fe2+, and Zn2+) involved in AD pathogenesis along with DNA protective potential against degenerative actions of OH radicals. Copper 45-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 32781220-6 2020 13b (most potent AChE inhibitor) also showed copper-induced Abeta1-42 aggregation inhibition (34.26 % at 50 muMu) and chelating properties for metal ions (Cu2+, Fe2+, and Zn2+) involved in AD pathogenesis along with DNA protective potential against degenerative actions of OH radicals. Metals 143-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 32781220-6 2020 13b (most potent AChE inhibitor) also showed copper-induced Abeta1-42 aggregation inhibition (34.26 % at 50 muMu) and chelating properties for metal ions (Cu2+, Fe2+, and Zn2+) involved in AD pathogenesis along with DNA protective potential against degenerative actions of OH radicals. cupric ion 155-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 32781220-6 2020 13b (most potent AChE inhibitor) also showed copper-induced Abeta1-42 aggregation inhibition (34.26 % at 50 muMu) and chelating properties for metal ions (Cu2+, Fe2+, and Zn2+) involved in AD pathogenesis along with DNA protective potential against degenerative actions of OH radicals. Zinc 171-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 32781220-7 2020 Molecular modelling studies confirm the potential of 13b in blocking both PAS and CAS of AChE. CHEMBL3741121 53-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 32781220-9 2020 Therefore, hybrid 13b can act as an effective hit lead molecule for further development of selective AChE inhibitors as multifunctional anti-Alzheimer"s agents. CHEMBL3741121 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 33054569-3 2022 While acetylcholinesterase (AChE) inhibitors such as donepezil and galantamine are leading drugs in the symptomatic treatment of AD, new AChE inhibitors continue to be explored for improved potency and selectivity. Donepezil 53-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 33138280-1 2020 We evaluated the potential of nine vitamin B3 scaffold-based derivatives as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors, as a starting point for the development of novel drugs for treating disorders with cholinergic neurotransmission-linked pathology. Niacinamide 35-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 33138280-1 2020 We evaluated the potential of nine vitamin B3 scaffold-based derivatives as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors, as a starting point for the development of novel drugs for treating disorders with cholinergic neurotransmission-linked pathology. Niacinamide 35-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 33138280-4 2020 The most potent inhibitor of both enzymes with Ki of 4 muM for AChE and 8 muM for BChE was the nicotinamide derivative 1-(4"-phenylphenacyl)-3-carbamoylpyridinium bromide. Niacinamide 95-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 33138280-4 2020 The most potent inhibitor of both enzymes with Ki of 4 muM for AChE and 8 muM for BChE was the nicotinamide derivative 1-(4"-phenylphenacyl)-3-carbamoylpyridinium bromide. 1-(4"-phenylphenacyl)-3-carbamoylpyridinium bromide 119-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 33066293-1 2020 A series of new oxindole-based spiro-heterocycles bearing the benzo[b]thiophene motif were synthesized via a 1,3-dipolar cycloaddition reaction and their acetylcholinesterase (AChE) inhibitory activity was evaluated. 2-oxindole 16-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-174 33066293-1 2020 A series of new oxindole-based spiro-heterocycles bearing the benzo[b]thiophene motif were synthesized via a 1,3-dipolar cycloaddition reaction and their acetylcholinesterase (AChE) inhibitory activity was evaluated. 2-oxindole 16-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 33066293-1 2020 A series of new oxindole-based spiro-heterocycles bearing the benzo[b]thiophene motif were synthesized via a 1,3-dipolar cycloaddition reaction and their acetylcholinesterase (AChE) inhibitory activity was evaluated. benzothiophene 62-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-174 33066293-1 2020 A series of new oxindole-based spiro-heterocycles bearing the benzo[b]thiophene motif were synthesized via a 1,3-dipolar cycloaddition reaction and their acetylcholinesterase (AChE) inhibitory activity was evaluated. benzothiophene 62-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 33030113-2 2021 More recently, a novel series of 4-N-phenylaminoquinolines was synthesized and evaluated against AChE and BuChE in which one of the compounds displayed appreciable inhibition compared to the standard compound, galantamine. 4-n-phenylaminoquinolines 33-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 33030113-2 2021 More recently, a novel series of 4-N-phenylaminoquinolines was synthesized and evaluated against AChE and BuChE in which one of the compounds displayed appreciable inhibition compared to the standard compound, galantamine. Galantamine 210-221 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 32761307-7 2020 Addition of the AChE inhibitors neostigmine and territrem B reduced apoptotic cell death under normal culture conditions. Neostigmine 32-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 33178356-0 2020 Vicinal difluorination as a C=C surrogate: an analog of piperine with enhanced solubility, photostability, and acetylcholinesterase inhibitory activity. piperine 56-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 33178356-4 2020 We show that this fluorinated analog of piperine has superior physicochemical properties, and it also has higher potency and selectivity towards one particular drug target, acetylcholinesterase. piperine 40-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-193 32712274-8 2020 Through several well-known molecules (e.g. huperzine) and new examples (tocopherol, trifluoroacetophenone and a 6-methyluracil alkylammonium derivative), we show that slow-binding inhibitors of acetylcholinesterase are promising drugs for treatment of neurological diseases such as Alzheimer disease and myasthenia gravis. huperzine A 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 194-214 32712274-8 2020 Through several well-known molecules (e.g. huperzine) and new examples (tocopherol, trifluoroacetophenone and a 6-methyluracil alkylammonium derivative), we show that slow-binding inhibitors of acetylcholinesterase are promising drugs for treatment of neurological diseases such as Alzheimer disease and myasthenia gravis. Tocopherols 72-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 194-214 32712274-8 2020 Through several well-known molecules (e.g. huperzine) and new examples (tocopherol, trifluoroacetophenone and a 6-methyluracil alkylammonium derivative), we show that slow-binding inhibitors of acetylcholinesterase are promising drugs for treatment of neurological diseases such as Alzheimer disease and myasthenia gravis. phenyl trifluoromethyl ketone 84-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 194-214 32712274-8 2020 Through several well-known molecules (e.g. huperzine) and new examples (tocopherol, trifluoroacetophenone and a 6-methyluracil alkylammonium derivative), we show that slow-binding inhibitors of acetylcholinesterase are promising drugs for treatment of neurological diseases such as Alzheimer disease and myasthenia gravis. 6-methyluracil alkylammonium 112-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 194-214 33047663-1 2022 Recently, we designed and synthesized a subnanomolar, reversible, dual-binding site acetylcholinesterase (AChE) inhibitor which consists of the tacrine and aroylacrylic acid phenylamide moieties, mutually linked by eight methylene units. Tacrine 144-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 33047663-1 2022 Recently, we designed and synthesized a subnanomolar, reversible, dual-binding site acetylcholinesterase (AChE) inhibitor which consists of the tacrine and aroylacrylic acid phenylamide moieties, mutually linked by eight methylene units. Tacrine 144-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 33047663-1 2022 Recently, we designed and synthesized a subnanomolar, reversible, dual-binding site acetylcholinesterase (AChE) inhibitor which consists of the tacrine and aroylacrylic acid phenylamide moieties, mutually linked by eight methylene units. aroylacrylic acid phenylamide 156-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 33047663-1 2022 Recently, we designed and synthesized a subnanomolar, reversible, dual-binding site acetylcholinesterase (AChE) inhibitor which consists of the tacrine and aroylacrylic acid phenylamide moieties, mutually linked by eight methylene units. aroylacrylic acid phenylamide 156-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 32877611-0 2020 Feasibility of Acetylcholinesterase Reaction Assay Monitoring in DIUTHAME-MS. DIUTHAME (desorption ionization using through hole alumina membrane) is a novel matrix-free laser desorption/ionization method that enables highly reproducible acquisition of mass spectra. Aluminum Oxide 129-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 32877611-1 2020 This study aims to evaluate the applicability of DIUTHAME to the acetylcholinesterase reaction assay (AChE assay) commonly used in high-throughput screening (HTS) in the drug discovery process. diuthame 49-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 32877611-1 2020 This study aims to evaluate the applicability of DIUTHAME to the acetylcholinesterase reaction assay (AChE assay) commonly used in high-throughput screening (HTS) in the drug discovery process. diuthame 49-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 32877611-7 2020 DIUTHAME is potentially able to provide more precise AChE reaction kinetics plots than what have been accomplished by MALDI. diuthame 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 33020380-3 2020 The aim of this paper was to fractionate and isolate alkaloids by developing an innovative vacuum liquid chromatography method for a species of Narcissus c.v. "Hawera" rarely investigated so far and establishing the inhibitory activity of acetylcholinesterase (AChE). Alkaloids 53-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 239-259 33020380-3 2020 The aim of this paper was to fractionate and isolate alkaloids by developing an innovative vacuum liquid chromatography method for a species of Narcissus c.v. "Hawera" rarely investigated so far and establishing the inhibitory activity of acetylcholinesterase (AChE). Alkaloids 53-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 261-265 33020380-8 2020 The combination of these techniques confirmed the presence of the alkaloids and enabled the development of a modern method for the fractionation and isolation of the compounds with strong anti-AChE activity. Alkaloids 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-197 33163344-2 2020 Acetylcholinesterase (AChE), an enzyme hydrolyzing ACh, is expressed in immune cells suggesting non-classical function in inflammatory responses. Acetylcholine 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 33163344-11 2020 Together with hydrolysis of ACh, AChE plays a direct role in the regulation of inflammatory response. Acetylcholine 28-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 32643792-2 2020 In this study, a series of novel coumarin-1,2,3-triazole-acetamide hybrids was tested against some metabolic enzymes including alpha-glycosidase (alpha-Gly), alpha-amylase (alpha-Amy), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), human carbonic anhydrase I (hCA I), and hCA II. coumarin 33-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 185-205 32643792-2 2020 In this study, a series of novel coumarin-1,2,3-triazole-acetamide hybrids was tested against some metabolic enzymes including alpha-glycosidase (alpha-Gly), alpha-amylase (alpha-Amy), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), human carbonic anhydrase I (hCA I), and hCA II. coumarin 33-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-211 32643792-2 2020 In this study, a series of novel coumarin-1,2,3-triazole-acetamide hybrids was tested against some metabolic enzymes including alpha-glycosidase (alpha-Gly), alpha-amylase (alpha-Amy), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), human carbonic anhydrase I (hCA I), and hCA II. acetamide 57-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 185-205 32643792-2 2020 In this study, a series of novel coumarin-1,2,3-triazole-acetamide hybrids was tested against some metabolic enzymes including alpha-glycosidase (alpha-Gly), alpha-amylase (alpha-Amy), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), human carbonic anhydrase I (hCA I), and hCA II. acetamide 57-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-211 32643792-3 2020 The new coumarin-1,2,3-triazole-acetamide hybrids showed Ki values in the range of 483.50-1,243.04 nM against hCA I, 508.55-1,284.36 nM against hCA II, 24.85-132.85 nM against AChE, 27.17-1,104.36 nM against BChE, 590.42-1,104.36 nM against alpha-Gly, and 55.38-128.63 nM against alpha-Amy. coumarin 8-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 32643792-3 2020 The new coumarin-1,2,3-triazole-acetamide hybrids showed Ki values in the range of 483.50-1,243.04 nM against hCA I, 508.55-1,284.36 nM against hCA II, 24.85-132.85 nM against AChE, 27.17-1,104.36 nM against BChE, 590.42-1,104.36 nM against alpha-Gly, and 55.38-128.63 nM against alpha-Amy. Triazoles 17-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 32643792-3 2020 The new coumarin-1,2,3-triazole-acetamide hybrids showed Ki values in the range of 483.50-1,243.04 nM against hCA I, 508.55-1,284.36 nM against hCA II, 24.85-132.85 nM against AChE, 27.17-1,104.36 nM against BChE, 590.42-1,104.36 nM against alpha-Gly, and 55.38-128.63 nM against alpha-Amy. acetamide 32-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 32891857-0 2020 Synthesis of nitrogen, phosphorus, selenium and sulfur-containing heterocyclic compounds - Determination of their carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and alpha-glycosidase inhibition properties. Nitrogen 13-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 32891857-0 2020 Synthesis of nitrogen, phosphorus, selenium and sulfur-containing heterocyclic compounds - Determination of their carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and alpha-glycosidase inhibition properties. Sulfur 48-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 32692899-1 2020 Four xanthone derivatives were synthesized and evaluated as acetylcholinesterase inhibitors (AChEIs) with metal chelating ability and antioxidant ability against Alzheimer"s disease (AD). xanthone 5-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 32692899-1 2020 Four xanthone derivatives were synthesized and evaluated as acetylcholinesterase inhibitors (AChEIs) with metal chelating ability and antioxidant ability against Alzheimer"s disease (AD). Metals 106-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 32692899-3 2020 Among them, 3-(2-( pyrrolidinyl)ethoxy)-1- hydroxy-9H-xanthen-9-one ( 2 ) had the highest ability to inhibit AChE and displayed high selectivity towards AChE (IC 50 =2.403+-0.002 muM for AChE and IC 50 =31.221+-0.002 muM for BuChE). 3-(2-( pyrrolidinyl)ethoxy)-1- hydroxy-9h-xanthen-9-one 12-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 32692899-3 2020 Among them, 3-(2-( pyrrolidinyl)ethoxy)-1- hydroxy-9H-xanthen-9-one ( 2 ) had the highest ability to inhibit AChE and displayed high selectivity towards AChE (IC 50 =2.403+-0.002 muM for AChE and IC 50 =31.221+-0.002 muM for BuChE). 3-(2-( pyrrolidinyl)ethoxy)-1- hydroxy-9h-xanthen-9-one 12-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 32692899-3 2020 Among them, 3-(2-( pyrrolidinyl)ethoxy)-1- hydroxy-9H-xanthen-9-one ( 2 ) had the highest ability to inhibit AChE and displayed high selectivity towards AChE (IC 50 =2.403+-0.002 muM for AChE and IC 50 =31.221+-0.002 muM for BuChE). 3-(2-( pyrrolidinyl)ethoxy)-1- hydroxy-9h-xanthen-9-one 12-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 32692899-6 2020 Interestingly, the copper complex ( 2 -Cu 2+ ) showed more significant inhibitory activity for AChE (IC 50 =0.934+-0.002 muM) and antioxidant activity (IC 50 =1.064+-0.003 muM). Copper 19-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 32801088-4 2020 The features appearing in the model against AChE enzyme suggest that a small ring size, higher number of -CH2- groups, higher number of secondary aromatic amines and higher number of aromatic ketone groups may contribute to the inhibitory activity. aromatic amines 146-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 32801088-4 2020 The features appearing in the model against AChE enzyme suggest that a small ring size, higher number of -CH2- groups, higher number of secondary aromatic amines and higher number of aromatic ketone groups may contribute to the inhibitory activity. aromatic ketone 183-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 32801088-6 2020 The features obtained from selectivity based model suggest that the number of aromatic ethers, unsaturation content relative to the molecular size and molecular shape may be more specific for the inhibition of the AChE enzyme in comparison to the BuChE enzyme. Ethers 87-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-218 32688201-5 2020 The top-ranked candidates in terms of the most pronounced potency against POP, AChE and BChE can be classified as 4d, 4u and 4v, bearing 4-methylbenzyl, (naphthalen-2-yl)methylene and 1-phenoxyethyl moieties, respectively. 4-Methylbenzyl radical 137-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 32470371-3 2020 The geranylated compounds, cowanin (13), cowagarcinone E (15), norcowanin (16) and cowanol (17) exhibited potent inhibitions against acetylcholinesterase (AChE) (IC50 0.33-1.09 muM) and butyrylcholinesterase (BChE) (IC50 0.048-1.84 muM), which were more active than the reference drug, galanthamine. cowanin 27-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 32470371-3 2020 The geranylated compounds, cowanin (13), cowagarcinone E (15), norcowanin (16) and cowanol (17) exhibited potent inhibitions against acetylcholinesterase (AChE) (IC50 0.33-1.09 muM) and butyrylcholinesterase (BChE) (IC50 0.048-1.84 muM), which were more active than the reference drug, galanthamine. cowanin 27-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 32470371-3 2020 The geranylated compounds, cowanin (13), cowagarcinone E (15), norcowanin (16) and cowanol (17) exhibited potent inhibitions against acetylcholinesterase (AChE) (IC50 0.33-1.09 muM) and butyrylcholinesterase (BChE) (IC50 0.048-1.84 muM), which were more active than the reference drug, galanthamine. Cowagarcinone E 41-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 32470371-3 2020 The geranylated compounds, cowanin (13), cowagarcinone E (15), norcowanin (16) and cowanol (17) exhibited potent inhibitions against acetylcholinesterase (AChE) (IC50 0.33-1.09 muM) and butyrylcholinesterase (BChE) (IC50 0.048-1.84 muM), which were more active than the reference drug, galanthamine. Cowagarcinone E 41-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 32470371-3 2020 The geranylated compounds, cowanin (13), cowagarcinone E (15), norcowanin (16) and cowanol (17) exhibited potent inhibitions against acetylcholinesterase (AChE) (IC50 0.33-1.09 muM) and butyrylcholinesterase (BChE) (IC50 0.048-1.84 muM), which were more active than the reference drug, galanthamine. norcowanin 63-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 32470371-3 2020 The geranylated compounds, cowanin (13), cowagarcinone E (15), norcowanin (16) and cowanol (17) exhibited potent inhibitions against acetylcholinesterase (AChE) (IC50 0.33-1.09 muM) and butyrylcholinesterase (BChE) (IC50 0.048-1.84 muM), which were more active than the reference drug, galanthamine. norcowanin 63-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 32470371-3 2020 The geranylated compounds, cowanin (13), cowagarcinone E (15), norcowanin (16) and cowanol (17) exhibited potent inhibitions against acetylcholinesterase (AChE) (IC50 0.33-1.09 muM) and butyrylcholinesterase (BChE) (IC50 0.048-1.84 muM), which were more active than the reference drug, galanthamine. cowanol 83-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 32470371-3 2020 The geranylated compounds, cowanin (13), cowagarcinone E (15), norcowanin (16) and cowanol (17) exhibited potent inhibitions against acetylcholinesterase (AChE) (IC50 0.33-1.09 muM) and butyrylcholinesterase (BChE) (IC50 0.048-1.84 muM), which were more active than the reference drug, galanthamine. cowanol 83-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 32470371-3 2020 The geranylated compounds, cowanin (13), cowagarcinone E (15), norcowanin (16) and cowanol (17) exhibited potent inhibitions against acetylcholinesterase (AChE) (IC50 0.33-1.09 muM) and butyrylcholinesterase (BChE) (IC50 0.048-1.84 muM), which were more active than the reference drug, galanthamine. Galantamine 286-298 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 32470371-3 2020 The geranylated compounds, cowanin (13), cowagarcinone E (15), norcowanin (16) and cowanol (17) exhibited potent inhibitions against acetylcholinesterase (AChE) (IC50 0.33-1.09 muM) and butyrylcholinesterase (BChE) (IC50 0.048-1.84 muM), which were more active than the reference drug, galanthamine. Galantamine 286-298 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 33054569-3 2022 While acetylcholinesterase (AChE) inhibitors such as donepezil and galantamine are leading drugs in the symptomatic treatment of AD, new AChE inhibitors continue to be explored for improved potency and selectivity. Galantamine 67-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 33054569-9 2022 Another five compounds showed stronger docking scores against AChE than the clinically used donepezil including the most active isolated compound daucosterol (44), with a binding affinity of -10.11 kJ/mol towards AChE. Donepezil 92-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-217 33054569-9 2022 Another five compounds showed stronger docking scores against AChE than the clinically used donepezil including the most active isolated compound daucosterol (44), with a binding affinity of -10.11 kJ/mol towards AChE. lyoniside 146-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 33054569-9 2022 Another five compounds showed stronger docking scores against AChE than the clinically used donepezil including the most active isolated compound daucosterol (44), with a binding affinity of -10.11 kJ/mol towards AChE. lyoniside 146-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-217 33054569-10 2022 These findings broaden our understanding of Vincetoxicum metabolites and highlight the potential of glycosylated flavonoids as AChE inhibitors. Flavonoids 113-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 30373445-3 2020 Neostigmine is an acetylcholinesterase inhibitor that increases frequency of smooth muscle contraction by increasing acetylcholine at autonomic nervous system synapses. Neostigmine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 32454110-0 2020 The inefficacy of donepezil on glycated-AChE inhibition: Binding affinity, complex stability and mechanism. Donepezil 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 32454110-1 2020 Donepezil (DPZ) is a well-known drug for Alzheimer"s disease that inhibits acetylcholinesterase activity (AChE). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 32454110-1 2020 Donepezil (DPZ) is a well-known drug for Alzheimer"s disease that inhibits acetylcholinesterase activity (AChE). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 32454110-1 2020 Donepezil (DPZ) is a well-known drug for Alzheimer"s disease that inhibits acetylcholinesterase activity (AChE). Donepezil 11-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 32454110-1 2020 Donepezil (DPZ) is a well-known drug for Alzheimer"s disease that inhibits acetylcholinesterase activity (AChE). Donepezil 11-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 32454110-2 2020 In the present study, the inhibitory effect of DPZ on non-enzymatic glycated-AChE (GLY-AChE) was studied by different experimental and simulation techniques. Donepezil 47-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 32454110-2 2020 In the present study, the inhibitory effect of DPZ on non-enzymatic glycated-AChE (GLY-AChE) was studied by different experimental and simulation techniques. Donepezil 47-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 32454110-3 2020 The initial investigation revealed that glycation process could reduce AChE activity approximately 60% in the pure enzyme and 38% in the extracted crude AChE from neural cells cultured in the presence of high glucose (HG) concentration. Glucose 209-216 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 32454110-3 2020 The initial investigation revealed that glycation process could reduce AChE activity approximately 60% in the pure enzyme and 38% in the extracted crude AChE from neural cells cultured in the presence of high glucose (HG) concentration. Glucose 209-216 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 32454110-3 2020 The initial investigation revealed that glycation process could reduce AChE activity approximately 60% in the pure enzyme and 38% in the extracted crude AChE from neural cells cultured in the presence of high glucose (HG) concentration. Mercury 218-220 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 32454110-3 2020 The initial investigation revealed that glycation process could reduce AChE activity approximately 60% in the pure enzyme and 38% in the extracted crude AChE from neural cells cultured in the presence of high glucose (HG) concentration. Mercury 218-220 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 32454110-4 2020 It is suggested that glycation of lysine residues on the structure of AChE could change the conformation of the active site (Trp-86 and His-447) in a way that the orientation of acetylcholine interrupted. Lysine 34-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 32454110-4 2020 It is suggested that glycation of lysine residues on the structure of AChE could change the conformation of the active site (Trp-86 and His-447) in a way that the orientation of acetylcholine interrupted. Tryptophan 125-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 32454110-4 2020 It is suggested that glycation of lysine residues on the structure of AChE could change the conformation of the active site (Trp-86 and His-447) in a way that the orientation of acetylcholine interrupted. Histidine 136-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 32454110-4 2020 It is suggested that glycation of lysine residues on the structure of AChE could change the conformation of the active site (Trp-86 and His-447) in a way that the orientation of acetylcholine interrupted. Acetylcholine 178-191 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 32454110-6 2020 The KD values of AChE-DPZ and GLY-AChE-DPZ complexes were estimated to be 1.88 x 10-9 and 2.10 x 10-6, respectively. Donepezil 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 32454110-6 2020 The KD values of AChE-DPZ and GLY-AChE-DPZ complexes were estimated to be 1.88 x 10-9 and 2.10 x 10-6, respectively. Glycine 30-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 32454110-6 2020 The KD values of AChE-DPZ and GLY-AChE-DPZ complexes were estimated to be 1.88 x 10-9 and 2.10 x 10-6, respectively. Glycine 30-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 32454110-6 2020 The KD values of AChE-DPZ and GLY-AChE-DPZ complexes were estimated to be 1.88 x 10-9 and 2.10 x 10-6, respectively. Donepezil 39-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 32454110-6 2020 The KD values of AChE-DPZ and GLY-AChE-DPZ complexes were estimated to be 1.88 x 10-9 and 2.10 x 10-6, respectively. Donepezil 39-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 32454110-7 2020 The stability assessment showed that AChE-DPZ complex is more stable than the glycated complex. Donepezil 42-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 32759369-4 2020 Subsequent experiments demonstrated that 100% of NHPs pretreated with either dose of galantamine, challenged with soman, and posttreated with conventional antidotes survived 24 h. By contrast, given the same posttreatments, 0% and 40% of the NHPs pretreated, respectively, with vehicle and pyridostigmine bromide (1.2 mg/kg, oral), a peripherally acting reversible AChE inhibitor approved as pretreatment for military personnel at risk of exposure to soman, survived 24 h after the challenge. Galantamine 85-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 365-369 32613603-6 2020 Through molecular docking and therapeutic viability assays, we analyzed the inhibitory activity exerted by genistein on three major protein targets (AChE, BChE, and NMDA) involved in AD. Genistein 107-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 32632029-6 2020 Exposure to organophosphate and carbamate insecticides was quantified using erythrocyte acetylcholinesterase normalised by haemoglobin (AChE/Hb). Organophosphates 12-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 32632029-6 2020 Exposure to organophosphate and carbamate insecticides was quantified using erythrocyte acetylcholinesterase normalised by haemoglobin (AChE/Hb). Carbamates 32-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 32613603-10 2020 In silico analysis, suggest that genistein modulates positively the expression of AChE, BChE, and NMDA. Genistein 33-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 32888673-0 2020 Diterpenoid alkaloids from Aconitum anthoroideum that offer protection against MPP+-Induced apoptosis of SH-SY5Y cells and acetylcholinesterase inhibitory activity. Diterpenes 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-143 32835730-4 2020 Being lipophilic compounds, organophosphates readily penetrate the brain and block the enzyme acetylcholinesterase (AChE). Organophosphates 28-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 32888673-5 2020 Rotundifosine F showed a significant inhibitory activity against AChE (IC50 = 0.3 muM). rotundifosine f 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 32835730-4 2020 Being lipophilic compounds, organophosphates readily penetrate the brain and block the enzyme acetylcholinesterase (AChE). Organophosphates 28-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 32835730-6 2020 A major drawback of currently available oxime reactivators is their inability to reactivate AChE in the central nervous system (CNS) as they are unable to cross the blood-brain barrier. Oximes 40-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 32991579-4 2020 Interaction of the above-mentioned alkaloids with acetylcholinesterase enzyme and interleukins IL-6 and IL-8 was investigated in silico by molecular docking. Alkaloids 35-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 32991579-7 2020 The data obtained in silico corroborate the results of AChE enzyme inhibition, the IC50 values of 61.24muM for stepharine and 19.55muM for 5-N-methylmaytenine were found. stepharine 111-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 32991579-7 2020 The data obtained in silico corroborate the results of AChE enzyme inhibition, the IC50 values of 61.24muM for stepharine and 19.55muM for 5-N-methylmaytenine were found. 5-n-methylmaytenine 139-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 32992925-0 2020 Solvent Deuterium Oxide Isotope Effects on the Reactions of Organophosphorylated Acetylcholinesterase. Deuterium Oxide 8-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 32992925-1 2020 Organophosphates (OPs) are esters of substituted phosphates, phosphonates or phosphoramidates that react with acetylcholinesterase (AChE) by initially transferring the organophosphityl group to a serine residue in the enzyme active site, concomitant with loss of an alcohol or halide leaving group. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 32992925-1 2020 Organophosphates (OPs) are esters of substituted phosphates, phosphonates or phosphoramidates that react with acetylcholinesterase (AChE) by initially transferring the organophosphityl group to a serine residue in the enzyme active site, concomitant with loss of an alcohol or halide leaving group. Organophosphates 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 32992925-1 2020 Organophosphates (OPs) are esters of substituted phosphates, phosphonates or phosphoramidates that react with acetylcholinesterase (AChE) by initially transferring the organophosphityl group to a serine residue in the enzyme active site, concomitant with loss of an alcohol or halide leaving group. Esters 27-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 32992925-1 2020 Organophosphates (OPs) are esters of substituted phosphates, phosphonates or phosphoramidates that react with acetylcholinesterase (AChE) by initially transferring the organophosphityl group to a serine residue in the enzyme active site, concomitant with loss of an alcohol or halide leaving group. Phosphates 6-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 32992925-1 2020 Organophosphates (OPs) are esters of substituted phosphates, phosphonates or phosphoramidates that react with acetylcholinesterase (AChE) by initially transferring the organophosphityl group to a serine residue in the enzyme active site, concomitant with loss of an alcohol or halide leaving group. Organophosphonates 61-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 32992925-1 2020 Organophosphates (OPs) are esters of substituted phosphates, phosphonates or phosphoramidates that react with acetylcholinesterase (AChE) by initially transferring the organophosphityl group to a serine residue in the enzyme active site, concomitant with loss of an alcohol or halide leaving group. phosphoramidic acid 77-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 32992925-1 2020 Organophosphates (OPs) are esters of substituted phosphates, phosphonates or phosphoramidates that react with acetylcholinesterase (AChE) by initially transferring the organophosphityl group to a serine residue in the enzyme active site, concomitant with loss of an alcohol or halide leaving group. Serine 196-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 32992925-1 2020 Organophosphates (OPs) are esters of substituted phosphates, phosphonates or phosphoramidates that react with acetylcholinesterase (AChE) by initially transferring the organophosphityl group to a serine residue in the enzyme active site, concomitant with loss of an alcohol or halide leaving group. Alcohols 266-273 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 32941665-0 2021 Conducting Polymer-Based Electrochemical Biosensor for the Detection of Acetylthiocoline and Pesticides via Acetylcholinesterase. Polymers 11-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 32941665-0 2021 Conducting Polymer-Based Electrochemical Biosensor for the Detection of Acetylthiocoline and Pesticides via Acetylcholinesterase. acetylthiocoline 72-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 32892929-3 2020 With the assistance of acetylcholinesterase (AChE), acetylthiocholine (ATCh) is hydrolyzed into thiocholine (TCh) which can effectively etch the ultrathin MnO2 nanosheets, resulting in the dissociation of MnO2-CdS from the photoelectrode. Acetylthiocholine 52-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 32805836-0 2020 The Stimulus Response of GQDs Sensitized Tb/GMP ICP Nanoparticles with Dual-Responsive Ratiometric Fluorescence: Towards Point-of-Use Analysis of Acetylcholinesterase and Organophosphorus Pesticides Poisoning with Acetylcholinesterase as a Biomarker. Terbium 41-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-166 32805836-0 2020 The Stimulus Response of GQDs Sensitized Tb/GMP ICP Nanoparticles with Dual-Responsive Ratiometric Fluorescence: Towards Point-of-Use Analysis of Acetylcholinesterase and Organophosphorus Pesticides Poisoning with Acetylcholinesterase as a Biomarker. Terbium 41-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-234 32805836-1 2020 In this study, by rationally designing the stimulus response of graphene quantum dots (GQDs) sensitized Tb/GMP infinite coordination polymer (ICP) nanoparticles, we have constructed a smartphone-based colorimetric assay with ratiometric fluorescence, which could be applied for the detection of acetylcholinesterase (AChE) and organophosphorus pesticides (OPs) directly. Graphite 64-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 295-315 32805836-1 2020 In this study, by rationally designing the stimulus response of graphene quantum dots (GQDs) sensitized Tb/GMP infinite coordination polymer (ICP) nanoparticles, we have constructed a smartphone-based colorimetric assay with ratiometric fluorescence, which could be applied for the detection of acetylcholinesterase (AChE) and organophosphorus pesticides (OPs) directly. Graphite 64-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 317-321 32805836-1 2020 In this study, by rationally designing the stimulus response of graphene quantum dots (GQDs) sensitized Tb/GMP infinite coordination polymer (ICP) nanoparticles, we have constructed a smartphone-based colorimetric assay with ratiometric fluorescence, which could be applied for the detection of acetylcholinesterase (AChE) and organophosphorus pesticides (OPs) directly. Terbium 104-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 295-315 32805836-1 2020 In this study, by rationally designing the stimulus response of graphene quantum dots (GQDs) sensitized Tb/GMP infinite coordination polymer (ICP) nanoparticles, we have constructed a smartphone-based colorimetric assay with ratiometric fluorescence, which could be applied for the detection of acetylcholinesterase (AChE) and organophosphorus pesticides (OPs) directly. Terbium 104-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 317-321 32805836-4 2020 With the presence of thiocholine (TCh), an enzymatic product hydrolyzed from acetylthiocholine (ATCh) by AChE, the competitive coordination of Tb3+ between GMP and TCh results in the collapse of ICP network and thereby the release of GQDs into the solution, thus, the fluorescence of Tb/GMP turns off and the fluorescence of GQDs turns on. Thiocholine 21-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 32805836-4 2020 With the presence of thiocholine (TCh), an enzymatic product hydrolyzed from acetylthiocholine (ATCh) by AChE, the competitive coordination of Tb3+ between GMP and TCh results in the collapse of ICP network and thereby the release of GQDs into the solution, thus, the fluorescence of Tb/GMP turns off and the fluorescence of GQDs turns on. Thiocholine 34-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 32805836-4 2020 With the presence of thiocholine (TCh), an enzymatic product hydrolyzed from acetylthiocholine (ATCh) by AChE, the competitive coordination of Tb3+ between GMP and TCh results in the collapse of ICP network and thereby the release of GQDs into the solution, thus, the fluorescence of Tb/GMP turns off and the fluorescence of GQDs turns on. Acetylthiocholine 77-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 32805836-4 2020 With the presence of thiocholine (TCh), an enzymatic product hydrolyzed from acetylthiocholine (ATCh) by AChE, the competitive coordination of Tb3+ between GMP and TCh results in the collapse of ICP network and thereby the release of GQDs into the solution, thus, the fluorescence of Tb/GMP turns off and the fluorescence of GQDs turns on. Acetylthiocholine 96-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 32805836-4 2020 With the presence of thiocholine (TCh), an enzymatic product hydrolyzed from acetylthiocholine (ATCh) by AChE, the competitive coordination of Tb3+ between GMP and TCh results in the collapse of ICP network and thereby the release of GQDs into the solution, thus, the fluorescence of Tb/GMP turns off and the fluorescence of GQDs turns on. tb3+ 143-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 32805836-4 2020 With the presence of thiocholine (TCh), an enzymatic product hydrolyzed from acetylthiocholine (ATCh) by AChE, the competitive coordination of Tb3+ between GMP and TCh results in the collapse of ICP network and thereby the release of GQDs into the solution, thus, the fluorescence of Tb/GMP turns off and the fluorescence of GQDs turns on. guanosine 5'-monophosphorothioate 156-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 32805836-4 2020 With the presence of thiocholine (TCh), an enzymatic product hydrolyzed from acetylthiocholine (ATCh) by AChE, the competitive coordination of Tb3+ between GMP and TCh results in the collapse of ICP network and thereby the release of GQDs into the solution, thus, the fluorescence of Tb/GMP turns off and the fluorescence of GQDs turns on. Thiocholine 97-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 32805836-4 2020 With the presence of thiocholine (TCh), an enzymatic product hydrolyzed from acetylthiocholine (ATCh) by AChE, the competitive coordination of Tb3+ between GMP and TCh results in the collapse of ICP network and thereby the release of GQDs into the solution, thus, the fluorescence of Tb/GMP turns off and the fluorescence of GQDs turns on. Terbium 143-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 32805836-4 2020 With the presence of thiocholine (TCh), an enzymatic product hydrolyzed from acetylthiocholine (ATCh) by AChE, the competitive coordination of Tb3+ between GMP and TCh results in the collapse of ICP network and thereby the release of GQDs into the solution, thus, the fluorescence of Tb/GMP turns off and the fluorescence of GQDs turns on. guanosine 5'-monophosphorothioate 287-290 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 32805836-6 2020 Moreover, when OPs are subsequently introduced, the activity of AChE is blocked, thus preventing the stimulus response of GQDs@Tb/GMP ICP nanoparticles, leading to the fluorescent color change from greenish-blue to green, which could also be employed for OPs detection. OPS 15-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 32805836-6 2020 Moreover, when OPs are subsequently introduced, the activity of AChE is blocked, thus preventing the stimulus response of GQDs@Tb/GMP ICP nanoparticles, leading to the fluorescent color change from greenish-blue to green, which could also be employed for OPs detection. Terbium 127-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 32805836-6 2020 Moreover, when OPs are subsequently introduced, the activity of AChE is blocked, thus preventing the stimulus response of GQDs@Tb/GMP ICP nanoparticles, leading to the fluorescent color change from greenish-blue to green, which could also be employed for OPs detection. guanosine 5'-monophosphorothioate 130-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 32805836-6 2020 Moreover, when OPs are subsequently introduced, the activity of AChE is blocked, thus preventing the stimulus response of GQDs@Tb/GMP ICP nanoparticles, leading to the fluorescent color change from greenish-blue to green, which could also be employed for OPs detection. OPS 255-258 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 32892929-3 2020 With the assistance of acetylcholinesterase (AChE), acetylthiocholine (ATCh) is hydrolyzed into thiocholine (TCh) which can effectively etch the ultrathin MnO2 nanosheets, resulting in the dissociation of MnO2-CdS from the photoelectrode. Acetylthiocholine 52-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 32892929-3 2020 With the assistance of acetylcholinesterase (AChE), acetylthiocholine (ATCh) is hydrolyzed into thiocholine (TCh) which can effectively etch the ultrathin MnO2 nanosheets, resulting in the dissociation of MnO2-CdS from the photoelectrode. Acetylthiocholine 71-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 32892929-3 2020 With the assistance of acetylcholinesterase (AChE), acetylthiocholine (ATCh) is hydrolyzed into thiocholine (TCh) which can effectively etch the ultrathin MnO2 nanosheets, resulting in the dissociation of MnO2-CdS from the photoelectrode. Acetylthiocholine 71-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 32353659-0 2020 Ultra-highly sensitive organophosphorus biosensor based on chitosan/tin disulfide and British housefly acetylcholinesterase. organophosphorus 23-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 32892929-3 2020 With the assistance of acetylcholinesterase (AChE), acetylthiocholine (ATCh) is hydrolyzed into thiocholine (TCh) which can effectively etch the ultrathin MnO2 nanosheets, resulting in the dissociation of MnO2-CdS from the photoelectrode. Thiocholine 58-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 32353659-2 2020 In this paper, we report a highly sensitive biosensor for the determination of pesticides based on tin sulfide (SnS2) and chitosan (CHIT) nanocomposites decorated with a unique British housefly acetylcholinesterase (AChE). tin sulfide 99-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 194-214 32353659-2 2020 In this paper, we report a highly sensitive biosensor for the determination of pesticides based on tin sulfide (SnS2) and chitosan (CHIT) nanocomposites decorated with a unique British housefly acetylcholinesterase (AChE). tin sulfide 99-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 216-220 32892929-3 2020 With the assistance of acetylcholinesterase (AChE), acetylthiocholine (ATCh) is hydrolyzed into thiocholine (TCh) which can effectively etch the ultrathin MnO2 nanosheets, resulting in the dissociation of MnO2-CdS from the photoelectrode. Thiocholine 58-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 32892929-3 2020 With the assistance of acetylcholinesterase (AChE), acetylthiocholine (ATCh) is hydrolyzed into thiocholine (TCh) which can effectively etch the ultrathin MnO2 nanosheets, resulting in the dissociation of MnO2-CdS from the photoelectrode. Thiocholine 72-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 32892929-3 2020 With the assistance of acetylcholinesterase (AChE), acetylthiocholine (ATCh) is hydrolyzed into thiocholine (TCh) which can effectively etch the ultrathin MnO2 nanosheets, resulting in the dissociation of MnO2-CdS from the photoelectrode. Thiocholine 72-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 32892929-3 2020 With the assistance of acetylcholinesterase (AChE), acetylthiocholine (ATCh) is hydrolyzed into thiocholine (TCh) which can effectively etch the ultrathin MnO2 nanosheets, resulting in the dissociation of MnO2-CdS from the photoelectrode. manganese dioxide 155-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 32892929-3 2020 With the assistance of acetylcholinesterase (AChE), acetylthiocholine (ATCh) is hydrolyzed into thiocholine (TCh) which can effectively etch the ultrathin MnO2 nanosheets, resulting in the dissociation of MnO2-CdS from the photoelectrode. manganese dioxide 155-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 32892929-3 2020 With the assistance of acetylcholinesterase (AChE), acetylthiocholine (ATCh) is hydrolyzed into thiocholine (TCh) which can effectively etch the ultrathin MnO2 nanosheets, resulting in the dissociation of MnO2-CdS from the photoelectrode. manganese dioxide 205-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 32892929-3 2020 With the assistance of acetylcholinesterase (AChE), acetylthiocholine (ATCh) is hydrolyzed into thiocholine (TCh) which can effectively etch the ultrathin MnO2 nanosheets, resulting in the dissociation of MnO2-CdS from the photoelectrode. manganese dioxide 205-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 32892929-3 2020 With the assistance of acetylcholinesterase (AChE), acetylthiocholine (ATCh) is hydrolyzed into thiocholine (TCh) which can effectively etch the ultrathin MnO2 nanosheets, resulting in the dissociation of MnO2-CdS from the photoelectrode. Cadmium 210-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 32892929-3 2020 With the assistance of acetylcholinesterase (AChE), acetylthiocholine (ATCh) is hydrolyzed into thiocholine (TCh) which can effectively etch the ultrathin MnO2 nanosheets, resulting in the dissociation of MnO2-CdS from the photoelectrode. Cadmium 210-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 32892929-5 2020 OPs, as a specific inhibitor for AChE activity, can prevent the generation of TCh and the dissociation of MnO2 nanosheets, building a relationship between OPs concentration and photocurrent. OPS 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 32892929-5 2020 OPs, as a specific inhibitor for AChE activity, can prevent the generation of TCh and the dissociation of MnO2 nanosheets, building a relationship between OPs concentration and photocurrent. Thiocholine 78-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 32892929-5 2020 OPs, as a specific inhibitor for AChE activity, can prevent the generation of TCh and the dissociation of MnO2 nanosheets, building a relationship between OPs concentration and photocurrent. manganese dioxide 106-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 32892929-5 2020 OPs, as a specific inhibitor for AChE activity, can prevent the generation of TCh and the dissociation of MnO2 nanosheets, building a relationship between OPs concentration and photocurrent. OPS 155-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 32995619-0 2020 Molecular interaction of human acetylcholinesterase with trans-tephrostachin and derivatives for Alzheimer"s disease. trans-Tephrostachin 57-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 32632601-3 2020 In this sense, in this report a computational model of linear prediction of acetylcholinesterase inhibitory activity of steroids and triterpenes is presented. Steroids 120-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 32632601-3 2020 In this sense, in this report a computational model of linear prediction of acetylcholinesterase inhibitory activity of steroids and triterpenes is presented. Triterpenes 133-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 32995619-2 2020 Acetylcholinesterase suppression is the common approach to enhance the well-being of AD patients by increasing the duration of acetylcholine in the cholinergic synapses. Acetylcholine 127-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32932702-0 2020 Novel Acetylcholinesterase Inhibitors Based on Uracil Moiety for Possible Treatment of Alzheimer Disease. Uracil 47-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-26 33061904-1 2020 Acetylcholinesterase inhibitors (AChEIs) including donepezil (DNP) are considered to be the most promising therapeutic possibilities of Alzheimer"s disease (AD). Donepezil 51-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 33061904-1 2020 Acetylcholinesterase inhibitors (AChEIs) including donepezil (DNP) are considered to be the most promising therapeutic possibilities of Alzheimer"s disease (AD). Donepezil 62-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32787143-5 2020 MG-6267 was identified as the first dual inhibitor of AChE and microRNA-15b biogenesis. mg-6267 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 32899591-6 2020 On the other hand, theoretical calculations were performed to assess the differences in interaction modes and the reactivity of trimedoxime within the AChE active site. Trimedoxime 128-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 32891393-9 2020 The sensitive HPTLC-S9-AChE assay allowed the detection of neurotoxic chemicals with and without metabolic activation, at levels consistent with the threshold of toxicological concern of organophosphates and carbamates. Organophosphates 187-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 32891393-9 2020 The sensitive HPTLC-S9-AChE assay allowed the detection of neurotoxic chemicals with and without metabolic activation, at levels consistent with the threshold of toxicological concern of organophosphates and carbamates. Carbamates 208-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 32544483-0 2020 Oxime-mediated reactivation of organophosphate-inhibited acetylcholinesterase with emphasis on centrally-active oximes. Oximes 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 32544483-0 2020 Oxime-mediated reactivation of organophosphate-inhibited acetylcholinesterase with emphasis on centrally-active oximes. Organophosphates 31-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 32544483-0 2020 Oxime-mediated reactivation of organophosphate-inhibited acetylcholinesterase with emphasis on centrally-active oximes. Oximes 112-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 32899591-7 2020 Comparing theoretical and experimental data, it is possible to notice that the oxime, in most cases, showed better reactivation percentages at higher concentrations, with the best result for the reactivation of the AChE-VX adduct. Oximes 79-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 215-219 32544483-1 2020 This review provides an overview of the global research leading to the large number of compounds developed as reactivators of acetylcholinesterase inhibited by a variety of organophosphate compounds, most of which are nerve agents but also some insecticides. Organophosphates 173-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 32573008-2 2020 In the present work, a library of 3-hydroxy-3-phenacyloxindole analogs was screened for FAAH and ChEs (acetylcholinesterase [AChE]/butyrylcholinesterase [BuChE]) inhibition. 3-hydroxy-3-phenacyloxindole 34-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 32899576-0 2020 Synthesis, In Silico and In Vitro Evaluation of Some Flavone Derivatives for Acetylcholinesterase and BACE-1 Inhibitory Activity. flavone 53-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 32899576-2 2020 Flavones are flavonoid derivatives with various bioactive effects, including AChE and BACE-1 inhibition. Flavones 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 32899576-2 2020 Flavones are flavonoid derivatives with various bioactive effects, including AChE and BACE-1 inhibition. Flavonoids 13-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 32899431-1 2020 The detrimental effects of organophosphates (OPs) on human health are thought to be of systemic, i.e., irreversible inhibition of acetylcholinesterase (AChE) at nerve synapses. Organophosphates 27-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 32899431-1 2020 The detrimental effects of organophosphates (OPs) on human health are thought to be of systemic, i.e., irreversible inhibition of acetylcholinesterase (AChE) at nerve synapses. Organophosphates 27-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 32899431-1 2020 The detrimental effects of organophosphates (OPs) on human health are thought to be of systemic, i.e., irreversible inhibition of acetylcholinesterase (AChE) at nerve synapses. Organophosphates 45-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 32899431-1 2020 The detrimental effects of organophosphates (OPs) on human health are thought to be of systemic, i.e., irreversible inhibition of acetylcholinesterase (AChE) at nerve synapses. Organophosphates 45-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 32529657-4 2020 More specifically, ST11 (4-[3-(perfluorophenyl)triaz-1-en-1-yl]-N-(thiazol-2-yl)benzenesulfonamide) showed a highly efficient inhibition profile against hCA I, hCA II, and AChE, with KI values of 450.37 +- 50.35, 504.37 +- 57.22, and 68.28 +- 10.26 nM, respectively. st11 19-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-176 32529657-4 2020 More specifically, ST11 (4-[3-(perfluorophenyl)triaz-1-en-1-yl]-N-(thiazol-2-yl)benzenesulfonamide) showed a highly efficient inhibition profile against hCA I, hCA II, and AChE, with KI values of 450.37 +- 50.35, 504.37 +- 57.22, and 68.28 +- 10.26 nM, respectively. 4-[3-(perfluorophenyl)triaz-1-en-1-yl]-n-(thiazol-2-yl)benzenesulfonamide 25-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-176 32537757-6 2020 All tested quinoline derivatives were found to be effective inhibitors of acetylcholinesterase (AChE) and the human carbonic anhydrase I and II isoforms (hCA I and II), with Ki values of 46.04-956.82 nM for hCA I, 54.95-976.93 nM for hCA II, and 5.51-155.22 nM for AChE. quinoline 11-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 32537757-6 2020 All tested quinoline derivatives were found to be effective inhibitors of acetylcholinesterase (AChE) and the human carbonic anhydrase I and II isoforms (hCA I and II), with Ki values of 46.04-956.82 nM for hCA I, 54.95-976.93 nM for hCA II, and 5.51-155.22 nM for AChE. quinoline 11-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 32537757-6 2020 All tested quinoline derivatives were found to be effective inhibitors of acetylcholinesterase (AChE) and the human carbonic anhydrase I and II isoforms (hCA I and II), with Ki values of 46.04-956.82 nM for hCA I, 54.95-976.93 nM for hCA II, and 5.51-155.22 nM for AChE. quinoline 11-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 265-269 32738978-0 2020 Discovery of biphenyl pyrazole scaffold for neurodegenerative diseases: A novel class of acetylcholinesterase-centered multitargeted ligands. biphenyl pyrazole 13-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 32416396-2 2020 Using experimental and computational approaches, this story was to explore the neurotoxic response process of the target acetylcholinesterase (AChE) to chiral phenthoate and further decipher the microscopic mechanism of such toxicological effect at the enantiomeric level. phenthoate 159-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 32416396-2 2020 Using experimental and computational approaches, this story was to explore the neurotoxic response process of the target acetylcholinesterase (AChE) to chiral phenthoate and further decipher the microscopic mechanism of such toxicological effect at the enantiomeric level. phenthoate 159-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 32416396-3 2020 The results showed that the toxic reaction of AChE with chiral phenthoate exhibited significant enantioselectivity, and (R)-phenthoate (K=1.486 x 105 M-1) has a bioaffinity for the nerve enzyme nearly three times that of (S)-phenthoate (K=4.503 x 104 M-1). phenthoate 63-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 32416396-3 2020 The results showed that the toxic reaction of AChE with chiral phenthoate exhibited significant enantioselectivity, and (R)-phenthoate (K=1.486 x 105 M-1) has a bioaffinity for the nerve enzyme nearly three times that of (S)-phenthoate (K=4.503 x 104 M-1). (r)-phenthoate 120-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 32416396-3 2020 The results showed that the toxic reaction of AChE with chiral phenthoate exhibited significant enantioselectivity, and (R)-phenthoate (K=1.486 x 105 M-1) has a bioaffinity for the nerve enzyme nearly three times that of (S)-phenthoate (K=4.503 x 104 M-1). phenthoate 221-235 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 32416396-6 2020 Meanwhile, via analyzing the modes of toxic action and free energies, we can find that (R)-phenthoate has a strong inhibitory effect on the enzymatic activity of AChE, as compared with (S)-phenthoate, and electrostatic energy (-23.79/-17.77 kJ mol-1) played a critical role in toxicological reactions. (r)-phenthoate 87-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-166 32416396-6 2020 Meanwhile, via analyzing the modes of toxic action and free energies, we can find that (R)-phenthoate has a strong inhibitory effect on the enzymatic activity of AChE, as compared with (S)-phenthoate, and electrostatic energy (-23.79/-17.77 kJ mol-1) played a critical role in toxicological reactions. phenthoate 185-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-166 32798937-2 2020 Cholinesterase inhibitors (i.e. organophosphates and carbamates) are frequently used in agriculture and inhibit acetylcholinesterase (AChE) activity. Organophosphates 32-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 32798937-2 2020 Cholinesterase inhibitors (i.e. organophosphates and carbamates) are frequently used in agriculture and inhibit acetylcholinesterase (AChE) activity. Organophosphates 32-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 32798937-2 2020 Cholinesterase inhibitors (i.e. organophosphates and carbamates) are frequently used in agriculture and inhibit acetylcholinesterase (AChE) activity. Carbamates 53-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 32798937-2 2020 Cholinesterase inhibitors (i.e. organophosphates and carbamates) are frequently used in agriculture and inhibit acetylcholinesterase (AChE) activity. Carbamates 53-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 32590127-0 2020 Swertiamarin, a secoiridoid glycoside modulates nAChR and AChE activity. swertiamarin 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 32590127-0 2020 Swertiamarin, a secoiridoid glycoside modulates nAChR and AChE activity. Glycosides 28-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 32583098-3 2020 The reactivation was notable for both AChE and BChE inhibited by VX, cyclosarin, sarin and paraoxon, if quinuclidinium compounds contained the benzyl group attached to the quinuclidinium moiety. cyclohexyl methylphosphonofluoridate 69-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 32583098-3 2020 The reactivation was notable for both AChE and BChE inhibited by VX, cyclosarin, sarin and paraoxon, if quinuclidinium compounds contained the benzyl group attached to the quinuclidinium moiety. Sarin 74-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 32583098-3 2020 The reactivation was notable for both AChE and BChE inhibited by VX, cyclosarin, sarin and paraoxon, if quinuclidinium compounds contained the benzyl group attached to the quinuclidinium moiety. Paraoxon 91-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 32583098-3 2020 The reactivation was notable for both AChE and BChE inhibited by VX, cyclosarin, sarin and paraoxon, if quinuclidinium compounds contained the benzyl group attached to the quinuclidinium moiety. quinuclidinium 104-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 32583098-3 2020 The reactivation was notable for both AChE and BChE inhibited by VX, cyclosarin, sarin and paraoxon, if quinuclidinium compounds contained the benzyl group attached to the quinuclidinium moiety. quinuclidinium 172-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 33178419-9 2020 The metabolites of these thiocarbamate herbicides are rather poor inhibitors of AChE when compared to the organophosphorus ester, paraoxon or the monomethylcarbamate, eserine. Thiocarbamates 25-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 33178419-9 2020 The metabolites of these thiocarbamate herbicides are rather poor inhibitors of AChE when compared to the organophosphorus ester, paraoxon or the monomethylcarbamate, eserine. organophosphorus ester 106-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 32851915-0 2022 Design, synthesis, characterization, biological evaluation, and molecular docking studies of novel 1,2-aminopropanthiols substituted derivatives as selective carbonic anhydrase, acetylcholinesterase and alpha-glycosidase enzymes inhibitors. 1,2-aminopropanthiols 99-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-198 32867308-0 2020 Synthesis, In Silico and In Vitro Evaluation for Acetylcholinesterase and BACE-1 Inhibitory Activity of Some N-Substituted-4-Phenothiazine-Chalcones. Chalcones 139-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 32867308-2 2020 Chalcones are the flavonoid derivatives with diverse bioactivities, including AChE and BACE-1 inhibition. Chalcones 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 32867308-2 2020 Chalcones are the flavonoid derivatives with diverse bioactivities, including AChE and BACE-1 inhibition. Flavonoids 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 32867308-3 2020 In this study, a series of N-substituted-4-phenothiazine-chalcones was synthesized and tested for AChE and BACE-1 inhibitory activities. n-substituted-4-phenothiazine 27-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 32867308-3 2020 In this study, a series of N-substituted-4-phenothiazine-chalcones was synthesized and tested for AChE and BACE-1 inhibitory activities. Chalcones 57-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 32867308-8 2020 Two substances AC4 and AC12 exhibited the highest biological activities on both AChE and BACE-1. ac12 23-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 32833082-0 2020 A ratiometric fluorescence probe based on graphene quantum dots and o-phenylenediamine for highly sensitive detection of acetylcholinesterase activity. Graphite 42-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 32833082-0 2020 A ratiometric fluorescence probe based on graphene quantum dots and o-phenylenediamine for highly sensitive detection of acetylcholinesterase activity. 1,2-diaminobenzene 68-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 32833082-1 2020 By using graphene quantum dots (GQDs) and o-phenylenediamine (OPD), a ratiometric fluorescence probe was designed for the highly sensitive and selective detection of AChE. Graphite 9-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 32833082-1 2020 By using graphene quantum dots (GQDs) and o-phenylenediamine (OPD), a ratiometric fluorescence probe was designed for the highly sensitive and selective detection of AChE. 1,2-diaminobenzene 42-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 32833082-7 2020 When AChE was present, the substrate acetylthiocholine (ATCh) was hydrolyzed to thiocholine (TCh) that is capable of decomposing MnO2 nanosheets. Acetylthiocholine 37-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 32833082-7 2020 When AChE was present, the substrate acetylthiocholine (ATCh) was hydrolyzed to thiocholine (TCh) that is capable of decomposing MnO2 nanosheets. Acetylthiocholine 56-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 32833082-7 2020 When AChE was present, the substrate acetylthiocholine (ATCh) was hydrolyzed to thiocholine (TCh) that is capable of decomposing MnO2 nanosheets. Thiocholine 43-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 32833082-7 2020 When AChE was present, the substrate acetylthiocholine (ATCh) was hydrolyzed to thiocholine (TCh) that is capable of decomposing MnO2 nanosheets. Thiocholine 57-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 32833082-7 2020 When AChE was present, the substrate acetylthiocholine (ATCh) was hydrolyzed to thiocholine (TCh) that is capable of decomposing MnO2 nanosheets. manganese dioxide 129-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 32833082-15 2020 When AChE is present, acetylthiocholine iodide (ATCh) is hydrolyzed to thiocholine (TCh) with reducibility for decomposing MnO2 nanosheets. acetylthiocholine iodide 22-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 32833082-15 2020 When AChE is present, acetylthiocholine iodide (ATCh) is hydrolyzed to thiocholine (TCh) with reducibility for decomposing MnO2 nanosheets. Acetylthiocholine 48-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 32833082-15 2020 When AChE is present, acetylthiocholine iodide (ATCh) is hydrolyzed to thiocholine (TCh) with reducibility for decomposing MnO2 nanosheets. Thiocholine 28-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 32833082-15 2020 When AChE is present, acetylthiocholine iodide (ATCh) is hydrolyzed to thiocholine (TCh) with reducibility for decomposing MnO2 nanosheets. Thiocholine 49-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 32833082-15 2020 When AChE is present, acetylthiocholine iodide (ATCh) is hydrolyzed to thiocholine (TCh) with reducibility for decomposing MnO2 nanosheets. manganese dioxide 123-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 32825138-0 2020 Merged Tacrine-Based, Multitarget-Directed Acetylcholinesterase Inhibitors 2015-Present: Synthesis and Biological Activity. Tacrine 7-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 32825138-1 2020 Acetylcholinesterase is an important biochemical enzyme in that it controls acetylcholine-mediated neuronal transmission in the central nervous system, contains a unique structure with two binding sites connected by a gorge region, and it has historically been the main pharmacological target for treatment of Alzheimer"s disease. Acetylcholine 76-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32825138-3 2020 Tacrine, the first acetylcholinesterase inhibitor used clinically but withdrawn due to hepatotoxicity concerns, remains an important starting point in research for the development of multitarget-directed acetylcholinesterase inhibitors. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 32825138-3 2020 Tacrine, the first acetylcholinesterase inhibitor used clinically but withdrawn due to hepatotoxicity concerns, remains an important starting point in research for the development of multitarget-directed acetylcholinesterase inhibitors. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-224 32825138-4 2020 This review highlights tacrine-based, multitarget-directed acetylcholinesterase inhibitors published in the literature since 2015 with a specific focus on merged compounds (i.e., compounds where tacrine and a second pharmacophore show significant overlap in structure). Tacrine 23-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 33488212-0 2020 Synthesis and bioactivities of 1-(4-hydroxyphenyl)-2-((heteroaryl)thio)ethanones as carbonic anhydrase I, II and acetylcholinesterase inhibitors. 1-(4-hydroxyphenyl)-2-((heteroaryl)thio)ethanones 31-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-133 33488212-2 2020 Biological activities of the compounds bearing phenol and heteroaryl groups make them popular groups in drug design targeting important enzymes such as acetylcholinesterase (AChE, E.C.3.1.1.7) and carbonic anhydrases (CAs, EC 4.2.1.1). Phenol 47-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 33488212-2 2020 Biological activities of the compounds bearing phenol and heteroaryl groups make them popular groups in drug design targeting important enzymes such as acetylcholinesterase (AChE, E.C.3.1.1.7) and carbonic anhydrases (CAs, EC 4.2.1.1). Phenol 47-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 33488212-2 2020 Biological activities of the compounds bearing phenol and heteroaryl groups make them popular groups in drug design targeting important enzymes such as acetylcholinesterase (AChE, E.C.3.1.1.7) and carbonic anhydrases (CAs, EC 4.2.1.1). heteroaryl 58-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 33488212-2 2020 Biological activities of the compounds bearing phenol and heteroaryl groups make them popular groups in drug design targeting important enzymes such as acetylcholinesterase (AChE, E.C.3.1.1.7) and carbonic anhydrases (CAs, EC 4.2.1.1). heteroaryl 58-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 33488212-3 2020 1-(4-hydroxyphenyl)- 2-((aryl)thio)ethanones as possible AChE and CAs inhibitors were synthesized, and their chemical structures were confirmed by IR, 1H NMR, 13C NMR, and HRMS. 1-(4-hydroxyphenyl)- 2-((aryl)thio)ethanones 0-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 32874532-1 2020 Background: Acetylcholinesterase inhibitors (AChEis) including donepezil, galantamine and rivastigmine are used to treat Alzheimer"s disease (AD). Donepezil 63-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 32874532-1 2020 Background: Acetylcholinesterase inhibitors (AChEis) including donepezil, galantamine and rivastigmine are used to treat Alzheimer"s disease (AD). Galantamine 74-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 32874532-1 2020 Background: Acetylcholinesterase inhibitors (AChEis) including donepezil, galantamine and rivastigmine are used to treat Alzheimer"s disease (AD). Rivastigmine 90-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 32452394-1 2020 The rapid hydrolysis of acetylcholine (ACh), one of the key neurotransmitters in the human body, by the enzyme acetylcholinesterase (AChE) is fundamental for the termination of ACh impulse transmission. Acetylcholine 24-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 32452394-1 2020 The rapid hydrolysis of acetylcholine (ACh), one of the key neurotransmitters in the human body, by the enzyme acetylcholinesterase (AChE) is fundamental for the termination of ACh impulse transmission. Acetylcholine 24-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 32452394-1 2020 The rapid hydrolysis of acetylcholine (ACh), one of the key neurotransmitters in the human body, by the enzyme acetylcholinesterase (AChE) is fundamental for the termination of ACh impulse transmission. Acetylcholine 39-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 32452394-1 2020 The rapid hydrolysis of acetylcholine (ACh), one of the key neurotransmitters in the human body, by the enzyme acetylcholinesterase (AChE) is fundamental for the termination of ACh impulse transmission. Acetylcholine 39-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 32452394-1 2020 The rapid hydrolysis of acetylcholine (ACh), one of the key neurotransmitters in the human body, by the enzyme acetylcholinesterase (AChE) is fundamental for the termination of ACh impulse transmission. Acetylcholine 133-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 32452394-2 2020 Several chemicals, including organophosphorus (OP) pesticides, warfare agents and drugs, are AChE reversible or irreversible inhibitors, thus their rapid on-site detection is of primary importance. organophosphorus 29-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 32452394-4 2020 The biosensor exploits three coupled enzymatic reactions catalyzed by AChE, choline oxidase and horseradish peroxidase, leading to production of hydrogen peroxide, which is measured with an optimized luminol substrate. Hydrogen Peroxide 145-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 32452394-4 2020 The biosensor exploits three coupled enzymatic reactions catalyzed by AChE, choline oxidase and horseradish peroxidase, leading to production of hydrogen peroxide, which is measured with an optimized luminol substrate. Luminol 200-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 32454229-0 2020 Simple analogues of natural product chelerythrine: Discovery of a novel anticholinesterase 2-phenylisoquinolin-2-ium scaffold with excellent potency against acetylcholinesterase. chelerythrine 36-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-177 32454229-0 2020 Simple analogues of natural product chelerythrine: Discovery of a novel anticholinesterase 2-phenylisoquinolin-2-ium scaffold with excellent potency against acetylcholinesterase. SCHEMBL16470327 91-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-177 32454229-2 2020 The activity evaluation led to the discovery of seven compounds with potent anti-acetylcholinesterase activity with IC50 values of <=0.72 muM, superior to chelerythrine and standard drugs galantamine. chelerythrine 155-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 32454229-2 2020 The activity evaluation led to the discovery of seven compounds with potent anti-acetylcholinesterase activity with IC50 values of <=0.72 muM, superior to chelerythrine and standard drugs galantamine. Galantamine 188-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 32454229-5 2020 Molecular docking showed that the isoquinoline moiety is embedded in a cavity surrounded by four aromatic residues of acetylcholinesterase by the pi-pi action. isoquinoline 34-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 32416089-3 2020 To restore neuromuscular transmission and skeletal muscle strength, anesthesiologists typically administer peripherally acting acetylcholinesterase inhibitors such as neostigmine. Neostigmine 167-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 32416089-8 2020 Peripherally acting acetylcholinesterase inhibitors such as neostigmine should then only be administered when indicated and dosed based on results of the train-of-four ratio. Neostigmine 60-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 32803418-5 2020 When triazophos is present, the activity of AchE is inhibited, and I2-induced etching of gold nanorods results in triazophos concentration-dependent color change from brown to blue, pink, and red. triazophos 5-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 32803418-5 2020 When triazophos is present, the activity of AchE is inhibited, and I2-induced etching of gold nanorods results in triazophos concentration-dependent color change from brown to blue, pink, and red. triazophos 114-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 32639532-1 2020 The enantiomers of racemic 2-hydroxyimino-N-(azidophenylpropyl)acetamide-derived triple-binding oxime reactivators were separated, and tested for inhibition and reactivation of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibited with tabun (GA), cyclosarin (GF), sarin (GB), and VX. 2-hydroxyimino-n-(azidophenylpropyl)acetamide 27-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-197 32639532-1 2020 The enantiomers of racemic 2-hydroxyimino-N-(azidophenylpropyl)acetamide-derived triple-binding oxime reactivators were separated, and tested for inhibition and reactivation of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibited with tabun (GA), cyclosarin (GF), sarin (GB), and VX. 2-hydroxyimino-n-(azidophenylpropyl)acetamide 27-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-203 32785161-0 2020 Design of Curcumin and Flavonoid Derivatives with Acetylcholinesterase and Beta-Secretase Inhibitory Activities Using in Silico Approaches. Curcumin 10-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 32785161-0 2020 Design of Curcumin and Flavonoid Derivatives with Acetylcholinesterase and Beta-Secretase Inhibitory Activities Using in Silico Approaches. Flavonoids 23-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 32785161-5 2020 A combinatorial library containing more than 3 million structures of curcumin and flavonoid derivatives was generated and screened for drug-likeness and enzymatic inhibitory bioactivities against AChE and BACE-1 through the validated in silico models. Curcumin 69-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 196-200 32785161-5 2020 A combinatorial library containing more than 3 million structures of curcumin and flavonoid derivatives was generated and screened for drug-likeness and enzymatic inhibitory bioactivities against AChE and BACE-1 through the validated in silico models. Flavonoids 82-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 196-200 32785161-6 2020 A total of 47 substances (two curcumins and 45 flavonoids), with remarkable predicted pIC50 values against AChE and BACE-1 ranging from 4.24-5.11 (AChE) and 4.52-10.27 (BACE-1), were designed. Flavonoids 47-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 32785161-6 2020 A total of 47 substances (two curcumins and 45 flavonoids), with remarkable predicted pIC50 values against AChE and BACE-1 ranging from 4.24-5.11 (AChE) and 4.52-10.27 (BACE-1), were designed. Flavonoids 47-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 33042734-4 2020 Here, clioquinol (metal-ion chelating agent) and donepezil (acetylcholinesterase (AChE) inhibitor) co-encapsulated human serum albumin (HSA) nanoparticles (dcHGT NPs) are designed, which are modified with transcriptional activator protein (TAT) and monosialotetrahexosylganglioside (GM1). Donepezil 49-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 33042734-4 2020 Here, clioquinol (metal-ion chelating agent) and donepezil (acetylcholinesterase (AChE) inhibitor) co-encapsulated human serum albumin (HSA) nanoparticles (dcHGT NPs) are designed, which are modified with transcriptional activator protein (TAT) and monosialotetrahexosylganglioside (GM1). Donepezil 49-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 33042734-7 2020 The alleviation of Abeta-related inflammation and AChE-inhibited effect further synergistically adjust acetylcholine imbalance. Acetylcholine 103-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 32597916-10 2020 Based on the thiocholine (TCh) inhibition of the excellent peroxidase-like activity of Co3O4/MoO3 and the TCh generation via acetylcholinesterase (AChE) catalyzed hydrolysis of acetylthiocholine chloride (ATCh), the colorimetric platform was extended to screen AChE activity and its inhibitor. Thiocholine 13-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 32597916-10 2020 Based on the thiocholine (TCh) inhibition of the excellent peroxidase-like activity of Co3O4/MoO3 and the TCh generation via acetylcholinesterase (AChE) catalyzed hydrolysis of acetylthiocholine chloride (ATCh), the colorimetric platform was extended to screen AChE activity and its inhibitor. Thiocholine 13-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 261-265 32597916-10 2020 Based on the thiocholine (TCh) inhibition of the excellent peroxidase-like activity of Co3O4/MoO3 and the TCh generation via acetylcholinesterase (AChE) catalyzed hydrolysis of acetylthiocholine chloride (ATCh), the colorimetric platform was extended to screen AChE activity and its inhibitor. Thiocholine 26-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 32597916-10 2020 Based on the thiocholine (TCh) inhibition of the excellent peroxidase-like activity of Co3O4/MoO3 and the TCh generation via acetylcholinesterase (AChE) catalyzed hydrolysis of acetylthiocholine chloride (ATCh), the colorimetric platform was extended to screen AChE activity and its inhibitor. Thiocholine 26-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 261-265 32597916-10 2020 Based on the thiocholine (TCh) inhibition of the excellent peroxidase-like activity of Co3O4/MoO3 and the TCh generation via acetylcholinesterase (AChE) catalyzed hydrolysis of acetylthiocholine chloride (ATCh), the colorimetric platform was extended to screen AChE activity and its inhibitor. co3o4 87-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 32597916-10 2020 Based on the thiocholine (TCh) inhibition of the excellent peroxidase-like activity of Co3O4/MoO3 and the TCh generation via acetylcholinesterase (AChE) catalyzed hydrolysis of acetylthiocholine chloride (ATCh), the colorimetric platform was extended to screen AChE activity and its inhibitor. co3o4 87-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 261-265 32597916-10 2020 Based on the thiocholine (TCh) inhibition of the excellent peroxidase-like activity of Co3O4/MoO3 and the TCh generation via acetylcholinesterase (AChE) catalyzed hydrolysis of acetylthiocholine chloride (ATCh), the colorimetric platform was extended to screen AChE activity and its inhibitor. molybdenum trioxide 93-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 32597916-10 2020 Based on the thiocholine (TCh) inhibition of the excellent peroxidase-like activity of Co3O4/MoO3 and the TCh generation via acetylcholinesterase (AChE) catalyzed hydrolysis of acetylthiocholine chloride (ATCh), the colorimetric platform was extended to screen AChE activity and its inhibitor. molybdenum trioxide 93-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 261-265 32597916-10 2020 Based on the thiocholine (TCh) inhibition of the excellent peroxidase-like activity of Co3O4/MoO3 and the TCh generation via acetylcholinesterase (AChE) catalyzed hydrolysis of acetylthiocholine chloride (ATCh), the colorimetric platform was extended to screen AChE activity and its inhibitor. Thiocholine 106-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 32597916-10 2020 Based on the thiocholine (TCh) inhibition of the excellent peroxidase-like activity of Co3O4/MoO3 and the TCh generation via acetylcholinesterase (AChE) catalyzed hydrolysis of acetylthiocholine chloride (ATCh), the colorimetric platform was extended to screen AChE activity and its inhibitor. Acetylthiocholine chloride 177-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 32597916-10 2020 Based on the thiocholine (TCh) inhibition of the excellent peroxidase-like activity of Co3O4/MoO3 and the TCh generation via acetylcholinesterase (AChE) catalyzed hydrolysis of acetylthiocholine chloride (ATCh), the colorimetric platform was extended to screen AChE activity and its inhibitor. Acetylthiocholine chloride 177-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 261-265 32597916-10 2020 Based on the thiocholine (TCh) inhibition of the excellent peroxidase-like activity of Co3O4/MoO3 and the TCh generation via acetylcholinesterase (AChE) catalyzed hydrolysis of acetylthiocholine chloride (ATCh), the colorimetric platform was extended to screen AChE activity and its inhibitor. atch 205-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 32573008-2 2020 In the present work, a library of 3-hydroxy-3-phenacyloxindole analogs was screened for FAAH and ChEs (acetylcholinesterase [AChE]/butyrylcholinesterase [BuChE]) inhibition. 3-hydroxy-3-phenacyloxindole 34-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 32752941-4 2021 Remarkably, amongst the series, the compound 2 was identified as the most active inhibitor of both AChE (IC50 = 0.05 +- 0.01 muM) and BChE (IC50 = 0.09 +- 0.02 muM) relative to the standard Donepezil (IC50 = 0.09 +- 0.01 for AChE and 0.13 +- 0.04 muM for BChE). Donepezil 190-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 32573008-3 2020 1-Benzyl-3-hydroxy-3-(2",4"-dibromophenacyl)oxindole (16), the most promising compound, showed a balanced multifunctional profile with FAAH (IC50 = 8.7 +- 0.3 nM, competitive and reversible), AChE (IC50 = 28 +- 3 nM, mixed and reversible), and BuChE (IC50 = 65 +- 8 nM, mixed and reversible) inhibition. 1-benzyl-3-hydroxy-3-(2",4"-dibromophenacyl)oxindole 0-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-197 32752945-6 2021 According to the enzyme activity measurements, Ru(II) complex inhibited both GST and BChE enzymes, while Fe(II) complex inhibited only AChE enzyme. ammonium ferrous sulfate 105-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 32754990-0 2020 Nitrogen-containing flavonoid and their analogs with diverse B-ring in acetylcholinesterase and butyrylcholinesterase inhibition. Nitrogen 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 32754990-0 2020 Nitrogen-containing flavonoid and their analogs with diverse B-ring in acetylcholinesterase and butyrylcholinesterase inhibition. Flavonoids 20-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 32754990-3 2020 Compared with flavones, the inhibitory activity of 2-naphthyl chromone, 2-anthryl-chromone derivatives against AChE significantly decreased, while that of 2-biphenyl chromone derivatives with 7-substituted tertiary amine side chain is better than relative flavones derivatives. Flavones 14-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 32754990-3 2020 Compared with flavones, the inhibitory activity of 2-naphthyl chromone, 2-anthryl-chromone derivatives against AChE significantly decreased, while that of 2-biphenyl chromone derivatives with 7-substituted tertiary amine side chain is better than relative flavones derivatives. 2-naphthyl chromone 51-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 32754990-3 2020 Compared with flavones, the inhibitory activity of 2-naphthyl chromone, 2-anthryl-chromone derivatives against AChE significantly decreased, while that of 2-biphenyl chromone derivatives with 7-substituted tertiary amine side chain is better than relative flavones derivatives. 2-anthryl-chromone 72-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 32754990-4 2020 For all new synthesized compounds, the position of tertiary amine side chain obviously influenced the activity of inhibiting AChE. Amines 60-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 32650180-9 2020 Nickel complexes were studied against enzymes that are human carbonic anhydrase isozyme I for ID 2CAB (hCA I), butyrylcholinesterase for ID 1P0I (BChE), and acetylcholinesterase for ID 1EEA (AChE), respectively. Nickel 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 191-195 32746727-2 2021 The aim of this study was to investigate the effect of hydroquinone, 4-hydroxybenzoic acid, 3,5-dihydroxybenzoic acid, caffeic acid, vanillic acid and chlorogenic acid against acetylcholinesterase (AChE), partially purified from serum. hydroquinone 55-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-196 32746727-2 2021 The aim of this study was to investigate the effect of hydroquinone, 4-hydroxybenzoic acid, 3,5-dihydroxybenzoic acid, caffeic acid, vanillic acid and chlorogenic acid against acetylcholinesterase (AChE), partially purified from serum. 4-hydroxybenzoic acid 69-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-196 32746727-2 2021 The aim of this study was to investigate the effect of hydroquinone, 4-hydroxybenzoic acid, 3,5-dihydroxybenzoic acid, caffeic acid, vanillic acid and chlorogenic acid against acetylcholinesterase (AChE), partially purified from serum. alpha-resorcylic acid 92-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-196 32746727-2 2021 The aim of this study was to investigate the effect of hydroquinone, 4-hydroxybenzoic acid, 3,5-dihydroxybenzoic acid, caffeic acid, vanillic acid and chlorogenic acid against acetylcholinesterase (AChE), partially purified from serum. alpha-resorcylic acid 92-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-202 32746727-2 2021 The aim of this study was to investigate the effect of hydroquinone, 4-hydroxybenzoic acid, 3,5-dihydroxybenzoic acid, caffeic acid, vanillic acid and chlorogenic acid against acetylcholinesterase (AChE), partially purified from serum. caffeic acid 119-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-196 32746727-2 2021 The aim of this study was to investigate the effect of hydroquinone, 4-hydroxybenzoic acid, 3,5-dihydroxybenzoic acid, caffeic acid, vanillic acid and chlorogenic acid against acetylcholinesterase (AChE), partially purified from serum. Vanillic Acid 133-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-196 32746727-2 2021 The aim of this study was to investigate the effect of hydroquinone, 4-hydroxybenzoic acid, 3,5-dihydroxybenzoic acid, caffeic acid, vanillic acid and chlorogenic acid against acetylcholinesterase (AChE), partially purified from serum. Chlorogenic Acid 151-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-196 32746727-4 2021 Hydroquinone, chlorogenic acid and 4-hydroxybenzoic acid have been found to have higher inhibitory potential than others against the AChE. hydroquinone 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 32746727-4 2021 Hydroquinone, chlorogenic acid and 4-hydroxybenzoic acid have been found to have higher inhibitory potential than others against the AChE. Chlorogenic Acid 14-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 32746727-4 2021 Hydroquinone, chlorogenic acid and 4-hydroxybenzoic acid have been found to have higher inhibitory potential than others against the AChE. 4-hydroxybenzoic acid 35-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 32540077-0 2020 Identification of acetylcholinesterase inhibitors in water by combining two-dimensional thin-layer chromatography and high-resolution mass spectrometry. Water 53-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 32540077-14 2020 For the substances lumichrome, a derivate of riboflavin and paraxanthine as well as for linear alkylbenzene sulfonates that were applied as anionic surfactants in detergents, the inhibiting effect to the AChE could be confirmed. alkylbenzene sulfonates 95-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-208 32452582-0 2020 Novel benzo[b]xanthene derivatives: Bismuth(III) triflate-catalyzed one-pot synthesis, characterization, and acetylcholinesterase, glutathione S-transferase, and butyrylcholinesterase inhibitory properties. benzo[b]xanthene 6-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-129 32452582-0 2020 Novel benzo[b]xanthene derivatives: Bismuth(III) triflate-catalyzed one-pot synthesis, characterization, and acetylcholinesterase, glutathione S-transferase, and butyrylcholinesterase inhibitory properties. Bi(OTf)3 36-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-129 32452582-2 2020 The structural characterization of these novel substituted benzo[b]xanthenes was performed by spectroscopic methods, and their inhibitory actions against butyrylcholinesterase (BChE), acetylcholinesterase (AChE), and glutathione S-transferase (GST) were investigated. benzo[b]xanthenes 59-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-204 32452582-2 2020 The structural characterization of these novel substituted benzo[b]xanthenes was performed by spectroscopic methods, and their inhibitory actions against butyrylcholinesterase (BChE), acetylcholinesterase (AChE), and glutathione S-transferase (GST) were investigated. benzo[b]xanthenes 59-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 206-210 32452582-5 2020 Inhibition effects of the benzo[b]xanthene derivatives on AChE, BChE, and GST were found at the millimolar level. benzo[b]xanthene 26-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 32474181-6 2020 Among these, the best inhibitor against AChE enzyme is 2b (Ki 62.08 +- 11.67 microM and IC50 90.33), and against alpha-Gly, 2c showed the highest effect (Ki 0.33 +- 0.08 microM and IC50 0.28). alpha-gly 113-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 32454005-0 2020 Synthesis and in vitro evaluation of novel non-oximes for the reactivation of nerve agent inhibited human acetylcholinesterase. Oximes 47-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 32454005-1 2020 Since several decades oximes have been used as part of treatment of nerve agent intoxication with the aim to restore the biological function of the enzyme acetylcholinesterase after its covalent inhibition by organophosphorus compounds such as pesticides and nerve agents. Oximes 22-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-175 32454005-1 2020 Since several decades oximes have been used as part of treatment of nerve agent intoxication with the aim to restore the biological function of the enzyme acetylcholinesterase after its covalent inhibition by organophosphorus compounds such as pesticides and nerve agents. organophosphorus 209-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-175 32454005-5 2020 All compounds were assessed for their ability to reactivate human acetylcholinesterase inhibited by the nerve agents VX, tabun, sarin, cyclosarin and paraoxon in vitro. tabun 121-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 32454005-5 2020 All compounds were assessed for their ability to reactivate human acetylcholinesterase inhibited by the nerve agents VX, tabun, sarin, cyclosarin and paraoxon in vitro. Sarin 128-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 32454005-5 2020 All compounds were assessed for their ability to reactivate human acetylcholinesterase inhibited by the nerve agents VX, tabun, sarin, cyclosarin and paraoxon in vitro. cyclohexyl methylphosphonofluoridate 135-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 32454005-5 2020 All compounds were assessed for their ability to reactivate human acetylcholinesterase inhibited by the nerve agents VX, tabun, sarin, cyclosarin and paraoxon in vitro. Paraoxon 150-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 32731540-6 2020 Overall, the most active extracts in inhibiting both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were ethanol/water and ethanol extracts from seeds (between 31.11 and 53.90%). Ethanol 127-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 32492460-2 2020 Two inhibitors, 12-tungstosilicic acid (WSiA) and 12-tungstophosphoric acid (WPA), which have polyoxometalate (POM) type structure, have been shown to inhibit AChE activity in nM concentration. 12-tungstosilicic acid 16-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 32492460-2 2020 Two inhibitors, 12-tungstosilicic acid (WSiA) and 12-tungstophosphoric acid (WPA), which have polyoxometalate (POM) type structure, have been shown to inhibit AChE activity in nM concentration. wsia 40-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 32492460-2 2020 Two inhibitors, 12-tungstosilicic acid (WSiA) and 12-tungstophosphoric acid (WPA), which have polyoxometalate (POM) type structure, have been shown to inhibit AChE activity in nM concentration. 12-tungstophosphoric acid 50-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 32492460-2 2020 Two inhibitors, 12-tungstosilicic acid (WSiA) and 12-tungstophosphoric acid (WPA), which have polyoxometalate (POM) type structure, have been shown to inhibit AChE activity in nM concentration. wpa 77-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 32492460-2 2020 Two inhibitors, 12-tungstosilicic acid (WSiA) and 12-tungstophosphoric acid (WPA), which have polyoxometalate (POM) type structure, have been shown to inhibit AChE activity in nM concentration. polyoxometalate I 94-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 32492460-2 2020 Two inhibitors, 12-tungstosilicic acid (WSiA) and 12-tungstophosphoric acid (WPA), which have polyoxometalate (POM) type structure, have been shown to inhibit AChE activity in nM concentration. polyoxometalate I 111-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 32492460-2 2020 Two inhibitors, 12-tungstosilicic acid (WSiA) and 12-tungstophosphoric acid (WPA), which have polyoxometalate (POM) type structure, have been shown to inhibit AChE activity in nM concentration. Mechlorethamine 176-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 32229401-0 2020 Detection of organophosphorus pesticides with liquid crystals supported on the surface deposited with polyoxometalate-based acetylcholinesterase-responsive supramolecular spheres. organophosphorus 13-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 32229401-1 2020 Here, we demonstrate use of acetylcholinesterase (AChE)-responsive polyoxometalate (POM)/surfactant supramolecular spheres to build a liquid crystal (LC)-based sensing platform for detection of organophosphorus pesticides. polyoxometalate I 67-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 32229401-1 2020 Here, we demonstrate use of acetylcholinesterase (AChE)-responsive polyoxometalate (POM)/surfactant supramolecular spheres to build a liquid crystal (LC)-based sensing platform for detection of organophosphorus pesticides. polyoxometalate I 67-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 32229401-1 2020 Here, we demonstrate use of acetylcholinesterase (AChE)-responsive polyoxometalate (POM)/surfactant supramolecular spheres to build a liquid crystal (LC)-based sensing platform for detection of organophosphorus pesticides. organophosphorus 194-210 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 32229401-1 2020 Here, we demonstrate use of acetylcholinesterase (AChE)-responsive polyoxometalate (POM)/surfactant supramolecular spheres to build a liquid crystal (LC)-based sensing platform for detection of organophosphorus pesticides. organophosphorus 194-210 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 32229401-5 2020 Detection of organophosphates are successfully achieved as they are potent inhibitors of AChE. Organophosphates 13-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 32763546-3 2020 Galantamine is not only a reversible, competitive inhibitor of acetylcholinesterase but also a type I positive allosteric modulator of alpha7nACh receptors. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 32215836-9 2020 Acetylcholinesterase (AChE) enzyme activities were determined by a colorimetric assay towards to hBNs treatment. hbns 97-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32215836-9 2020 Acetylcholinesterase (AChE) enzyme activities were determined by a colorimetric assay towards to hBNs treatment. hbns 97-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 32731540-6 2020 Overall, the most active extracts in inhibiting both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were ethanol/water and ethanol extracts from seeds (between 31.11 and 53.90%). Ethanol 127-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 32731540-6 2020 Overall, the most active extracts in inhibiting both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were ethanol/water and ethanol extracts from seeds (between 31.11 and 53.90%). Water 135-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 32731540-6 2020 Overall, the most active extracts in inhibiting both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were ethanol/water and ethanol extracts from seeds (between 31.11 and 53.90%). Water 135-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 32731540-6 2020 Overall, the most active extracts in inhibiting both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were ethanol/water and ethanol extracts from seeds (between 31.11 and 53.90%). Ethanol 145-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 32731540-6 2020 Overall, the most active extracts in inhibiting both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were ethanol/water and ethanol extracts from seeds (between 31.11 and 53.90%). Ethanol 145-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 32096991-0 2020 Donepezil Inhibits Acetylcholinesterase via Multiple Binding Modes at Room Temperature. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 32096991-1 2020 Donepezil is a second generation acetylcholinesterase (AChE) inhibitor for treatment of Alzheimer"s disease (AD). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 32096991-1 2020 Donepezil is a second generation acetylcholinesterase (AChE) inhibitor for treatment of Alzheimer"s disease (AD). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 32096991-2 2020 AChE is important for neurotransmission at neuromuscular junctions and cholinergic brain synapses by hydrolyzing acetylcholine into acetate and choline. Acetylcholine 113-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 32096991-2 2020 AChE is important for neurotransmission at neuromuscular junctions and cholinergic brain synapses by hydrolyzing acetylcholine into acetate and choline. Acetates 132-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 32096991-2 2020 AChE is important for neurotransmission at neuromuscular junctions and cholinergic brain synapses by hydrolyzing acetylcholine into acetate and choline. Choline 71-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 32096991-3 2020 In vitro data support that donepezil is a reversible, mixed competitive and non-competitive inhibitor of AChE. Donepezil 27-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 32096991-9 2020 All together, our findings support a physiologically-relevant mechanism of AChE inhibition by donepezil involving multistable interactions modes at the molecular origin of inhibitor"s activity. Donepezil 94-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 32705955-8 2021 Next, liposolubity prediction and commercially available showed that ZINC43198636, ZINC43198637 and ZINC00390718 can be potential dual inhibitors against hAChE and hBuChE. ZINC43198636 69-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-159 32705955-8 2021 Next, liposolubity prediction and commercially available showed that ZINC43198636, ZINC43198637 and ZINC00390718 can be potential dual inhibitors against hAChE and hBuChE. ZINC43198637 83-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-159 32939274-4 2020 A careful analysis of the chemical environment of disulfide bonds in the structures of elastase, lysozyme, acetylcholinesterase and other proteins suggests that S-S bonds which engage in a close contact with a carbonyl O atom along the extension of the S-S bond vector are more susceptible to reduction than the others. Disulfides 50-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 32717861-2 2020 GAL acts mainly as an inhibitor of the enzyme acetylcholinesterase (AChE). Galantamine 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 32717861-2 2020 GAL acts mainly as an inhibitor of the enzyme acetylcholinesterase (AChE). Galantamine 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 32717861-4 2020 Here, we combine GAL core with CU fragments and design a combinatorial library of GAL-CU hybrids as dual-site binding AChE inhibitors. Galantamine 17-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 32717861-4 2020 Here, we combine GAL core with CU fragments and design a combinatorial library of GAL-CU hybrids as dual-site binding AChE inhibitors. Curcumin 31-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 32717861-4 2020 Here, we combine GAL core with CU fragments and design a combinatorial library of GAL-CU hybrids as dual-site binding AChE inhibitors. gal-cu 82-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 32613964-2 2020 Organophosphorus pesticides show marked specificity for the enzyme acetylcholinesterase, and can cause irreversible harm to the nervous system. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 32765630-3 2020 The plant kingdom is extremely rich in a variety of compounds that are potent AChE inhibitors: flavonoids and other phenolic compounds have been recognized as promising Alzheimer"s treatment agents. Flavonoids 95-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 32765630-8 2020 Results: The acetylcholinesterase inhibitory activity from Q. suber cork and corkback ethanol-water extracts was as follows: 62% inhibition with corkback extracts over 0.5 mg/mL and around 49% inhibition in cork extracts over 1.0 mg/mL extracts" concentration. Ethanol 86-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-33 32765630-8 2020 Results: The acetylcholinesterase inhibitory activity from Q. suber cork and corkback ethanol-water extracts was as follows: 62% inhibition with corkback extracts over 0.5 mg/mL and around 49% inhibition in cork extracts over 1.0 mg/mL extracts" concentration. Water 94-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-33 32708417-6 2020 The activity of AChE and the HMGR were inhibited by the extracts giving IC50 values of 15.0 +- 0.1 microg/mL and 4.2 +- 0.1 microg/mL, respectively and 45% of the cholesterol permeation inhibition. Cholesterol 163-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 32380385-2 2020 These compounds were designed as dual binding site AChE inhibitors: they possess an arylalkylamine moiety connected via an alkyl chain to a 3-hydroxy-4-pyridone fragment, to allow the simultaneous interaction with catalytic active site (CAS) and peripheral anionic site (PAS) of the enzyme. arylalkylamine 84-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 32380385-2 2020 These compounds were designed as dual binding site AChE inhibitors: they possess an arylalkylamine moiety connected via an alkyl chain to a 3-hydroxy-4-pyridone fragment, to allow the simultaneous interaction with catalytic active site (CAS) and peripheral anionic site (PAS) of the enzyme. 3-hydroxy-4-pyridone 140-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 32388114-0 2020 Synthesis, in vitro evaluation and molecular docking of a new class of indolylpropyl benzamidopiperazines as dual AChE and SERT ligands for Alzheimer"s disease. indolylpropyl benzamidopiperazines 71-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 32388114-4 2020 For such purpose, a new series of indolylpropyl-piperazinyl oxoethyl-benzamido piperazines were synthesized and evaluated as multitarget-directed drugs for the serotonin transporter (SERT) and acetylcholinesterase (AChE). indolylpropyl-piperazinyl oxoethyl-benzamido piperazines 34-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-213 32388114-4 2020 For such purpose, a new series of indolylpropyl-piperazinyl oxoethyl-benzamido piperazines were synthesized and evaluated as multitarget-directed drugs for the serotonin transporter (SERT) and acetylcholinesterase (AChE). indolylpropyl-piperazinyl oxoethyl-benzamido piperazines 34-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 215-219 32551623-1 2020 Acetylcholinesterase inactivating compounds, such as organophosphate (OP) and carbamate (CM) pesticides, are widely used in agriculture to ensure sustainable production of food and feed. Organophosphates 53-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32551623-1 2020 Acetylcholinesterase inactivating compounds, such as organophosphate (OP) and carbamate (CM) pesticides, are widely used in agriculture to ensure sustainable production of food and feed. Carbamates 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32551623-1 2020 Acetylcholinesterase inactivating compounds, such as organophosphate (OP) and carbamate (CM) pesticides, are widely used in agriculture to ensure sustainable production of food and feed. Carbamates 89-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32630769-0 2020 In Vitro Interaction of Organophosphono- and Organophosphorothioates with Human Acetylcholinesterase. organophosphono- and organophosphorothioates 24-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 32630769-6 2020 Our aim was to determine the in vitro inhibition kinetics of selected organophosphono- and organophosphorothioates with human AChE, as well as hydrolysis of the agents in human plasma and reactivation of inhibited AChE, in order to derive potential structure-activity relationships. organophosphono- and organophosphorothioates 70-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 32630769-7 2020 The investigation of the interactions of selected OP compounds belonging to schedule 1 (V-agents) and schedule 2 (amiton) of the CWC with human AChE revealed distinct structural effects of the P-alkyl, P-O-alkyl and N,N-dialkyl residues on the inhibitory potency of the agents. amiton 114-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 32279763-1 2020 Herein we report a multiplated and biopolymeric-based optical bioassay for organophosphate detection based on the use of acetylcholinesterase (AChE) as biocomponent and biopolymeric electrospun fibrous mats as eco-designed supports for AChE immobilisation. Organophosphates 75-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 32305437-1 2020 Human Cathepsin A (CatA) is a lysosomal serine carboxypeptidase of the renin-angiotensin system (RAS) and is structurally similar to acetylcholinesterase (AChE). Serine 40-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 32305437-5 2020 Bimolecular rate constants for inhibition by cyclosarin and VR were 1.3 x 103 M-1sec-1 and 1.2 x 103 M-1sec-1, respectively, and were approximately 3-orders of magnitude lower than those of human AChE indicating slower reactivity. cyclohexyl methylphosphonofluoridate 45-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 196-200 32305437-6 2020 Notably, both AChE and CatA bound diisopropylfluorophosphate (DFP) comparably and had KIDFP = 13 microM and 11 microM, respectively. Isoflurophate 34-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 32305437-6 2020 Notably, both AChE and CatA bound diisopropylfluorophosphate (DFP) comparably and had KIDFP = 13 microM and 11 microM, respectively. Isoflurophate 62-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 32380389-4 2020 The organoruthenium-nitrophen complex [(eta6-p-cymene)Ru(nitrophen)Cl]Cl; C22H21Cl2N3O2Ru (C1-Cl) was synthesized, structurally characterized and evaluated in vitro for its inhibitory activity against electric eel acetylcholinesterase (eeAChE), human recombinant acetylcholinesterase (hrAChE), horse serum butyrylcholinesterase (hsBChE) and horse liver glutathione-S-transferase. organoruthenium-nitrophen 4-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-234 32380389-4 2020 The organoruthenium-nitrophen complex [(eta6-p-cymene)Ru(nitrophen)Cl]Cl; C22H21Cl2N3O2Ru (C1-Cl) was synthesized, structurally characterized and evaluated in vitro for its inhibitory activity against electric eel acetylcholinesterase (eeAChE), human recombinant acetylcholinesterase (hrAChE), horse serum butyrylcholinesterase (hsBChE) and horse liver glutathione-S-transferase. [(eta6-p-cymene 38-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-234 32380389-4 2020 The organoruthenium-nitrophen complex [(eta6-p-cymene)Ru(nitrophen)Cl]Cl; C22H21Cl2N3O2Ru (C1-Cl) was synthesized, structurally characterized and evaluated in vitro for its inhibitory activity against electric eel acetylcholinesterase (eeAChE), human recombinant acetylcholinesterase (hrAChE), horse serum butyrylcholinesterase (hsBChE) and horse liver glutathione-S-transferase. c1-cl 91-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-234 32388430-7 2020 The inhibition effects of the phenols compounds against AChE and BChE activities were analysed. Phenols 30-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 32388430-8 2020 Also, these phenols were found as effective inhibitors for AChE, hCA I, hCA II, and BChE with Kis in the range of 122.95 +- 18.41-351.31 +- 69.12 nM for hCA I, 62.35 +- 9.03-363.17 +- 180.1 nM for hCA II, 134.57 +- 3.99-457.43 +- 220.10 nM for AChE, and 27.06 +- 9.12-72.98 +- 9.53 nM for BChE, respectively. Phenols 12-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 32388430-8 2020 Also, these phenols were found as effective inhibitors for AChE, hCA I, hCA II, and BChE with Kis in the range of 122.95 +- 18.41-351.31 +- 69.12 nM for hCA I, 62.35 +- 9.03-363.17 +- 180.1 nM for hCA II, 134.57 +- 3.99-457.43 +- 220.10 nM for AChE, and 27.06 +- 9.12-72.98 +- 9.53 nM for BChE, respectively. Phenols 12-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 244-248 32388435-0 2020 Design, synthesis and evaluation of novel nonquaternary and 3 non-oxime reactivators for acetylcholinesterase inhibited by organophosphates. Oximes 66-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 32388435-0 2020 Design, synthesis and evaluation of novel nonquaternary and 3 non-oxime reactivators for acetylcholinesterase inhibited by organophosphates. Organophosphates 123-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 32388435-1 2020 A new series of novel nonquaternary conjugates and non-oxime reactivators for reactivation of both nerve agents and pesticides inhibited hAChE were described in this paper. Oximes 55-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-142 32388435-2 2020 Conjugates with piperazine linked to the substituted salicylaldoxime emerged as efficient reactivators for VX inhibited hAChE. Piperazine 16-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-125 32388435-2 2020 Conjugates with piperazine linked to the substituted salicylaldoxime emerged as efficient reactivators for VX inhibited hAChE. salicylaldoxime 53-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-125 32388435-4 2020 It was also found that some non-oxime derivatives of Mannich phenols displayed obvious reactivation potency for VX, sarin and pesticides inhibited hAChE even in very low concentration. Oximes 32-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-152 32388435-4 2020 It was also found that some non-oxime derivatives of Mannich phenols displayed obvious reactivation potency for VX, sarin and pesticides inhibited hAChE even in very low concentration. mannich 53-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-152 32388435-4 2020 It was also found that some non-oxime derivatives of Mannich phenols displayed obvious reactivation potency for VX, sarin and pesticides inhibited hAChE even in very low concentration. Phenols 61-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-152 32388435-4 2020 It was also found that some non-oxime derivatives of Mannich phenols displayed obvious reactivation potency for VX, sarin and pesticides inhibited hAChE even in very low concentration. Sarin 116-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-152 32388435-5 2020 It has been proved that introduction of peripheral site ligands with widespread aromatic system and amide substitutions could increase binding affinity for inhibited hAChE in most cases, which contribute to the reactivation efficiency. Amides 100-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-171 32356584-3 2020 Especially compounds 6c and 6e were found to be the most potent with relative AChE inhibition percentages of 87% in comparison to donepezil. Donepezil 130-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 32356584-4 2020 The docking studies with AChE showed similar interactions between Donepezil and these four derivatives. Donepezil 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 32267631-1 2020 Oximes like pralidoxime (2-PAM), obidoxime (Obi) and HI-6 are the only currently available therapeutics to reactivate inhibited acetylcholinesterase (AChE) in case of intoxications with organophosphorus (OP) compounds. Oximes 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 32267631-1 2020 Oximes like pralidoxime (2-PAM), obidoxime (Obi) and HI-6 are the only currently available therapeutics to reactivate inhibited acetylcholinesterase (AChE) in case of intoxications with organophosphorus (OP) compounds. Oximes 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 32267631-1 2020 Oximes like pralidoxime (2-PAM), obidoxime (Obi) and HI-6 are the only currently available therapeutics to reactivate inhibited acetylcholinesterase (AChE) in case of intoxications with organophosphorus (OP) compounds. pralidoxime 12-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 32267631-1 2020 Oximes like pralidoxime (2-PAM), obidoxime (Obi) and HI-6 are the only currently available therapeutics to reactivate inhibited acetylcholinesterase (AChE) in case of intoxications with organophosphorus (OP) compounds. pralidoxime 12-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 32267631-1 2020 Oximes like pralidoxime (2-PAM), obidoxime (Obi) and HI-6 are the only currently available therapeutics to reactivate inhibited acetylcholinesterase (AChE) in case of intoxications with organophosphorus (OP) compounds. Obidoxime Chloride 33-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 32267631-1 2020 Oximes like pralidoxime (2-PAM), obidoxime (Obi) and HI-6 are the only currently available therapeutics to reactivate inhibited acetylcholinesterase (AChE) in case of intoxications with organophosphorus (OP) compounds. Obidoxime Chloride 33-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 32267631-1 2020 Oximes like pralidoxime (2-PAM), obidoxime (Obi) and HI-6 are the only currently available therapeutics to reactivate inhibited acetylcholinesterase (AChE) in case of intoxications with organophosphorus (OP) compounds. Obidoxime Chloride 44-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 32267631-1 2020 Oximes like pralidoxime (2-PAM), obidoxime (Obi) and HI-6 are the only currently available therapeutics to reactivate inhibited acetylcholinesterase (AChE) in case of intoxications with organophosphorus (OP) compounds. Obidoxime Chloride 44-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 32267631-1 2020 Oximes like pralidoxime (2-PAM), obidoxime (Obi) and HI-6 are the only currently available therapeutics to reactivate inhibited acetylcholinesterase (AChE) in case of intoxications with organophosphorus (OP) compounds. asoxime chloride 53-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 32267631-1 2020 Oximes like pralidoxime (2-PAM), obidoxime (Obi) and HI-6 are the only currently available therapeutics to reactivate inhibited acetylcholinesterase (AChE) in case of intoxications with organophosphorus (OP) compounds. asoxime chloride 53-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 32267631-1 2020 Oximes like pralidoxime (2-PAM), obidoxime (Obi) and HI-6 are the only currently available therapeutics to reactivate inhibited acetylcholinesterase (AChE) in case of intoxications with organophosphorus (OP) compounds. organophosphorus 186-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 32267631-1 2020 Oximes like pralidoxime (2-PAM), obidoxime (Obi) and HI-6 are the only currently available therapeutics to reactivate inhibited acetylcholinesterase (AChE) in case of intoxications with organophosphorus (OP) compounds. organophosphorus 186-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 32656560-6 2020 A novel anti-AD tripeptide WIR with potent inhibition of AChE and BACE 1 was identified, with IC50 values of 43.32 +- 1.22 muM and 2.27 +- 0.35 mM, respectively. tripeptide K-26 16-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 32510415-2 2020 ZnPT decreased the burrowing activity and AChE activity with higher acute toxicities, implying its cholinergic effect. pyrithione zinc 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 32333945-0 2020 Efficient detoxification of nerve agents by oxime-assisted reactivation of acetylcholinesterase mutants. Oximes 44-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 32333945-2 2020 Poisonings by organophosphorus compounds (OP) that lead to life-threatening toxic manifestations require immediate treatment that combines administration of anticholinergic drugs and an aldoxime as a reactivator of AChE. Organophosphorus Compounds 14-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 215-219 32333945-5 2020 Therefore, this review focuses on oxime-assisted catalysis by AChE mutants that provides a potential means for degradation of organophosphates in the plasma before reaching the cellular target site. Oximes 34-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 32333945-5 2020 Therefore, this review focuses on oxime-assisted catalysis by AChE mutants that provides a potential means for degradation of organophosphates in the plasma before reaching the cellular target site. Organophosphates 126-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 32478771-4 2020 The QDs successfully enabled the detection of low concentrations of AChE by turning on the fluorescence of the CdTe/CP via the interaction between CP and thiocholine produced by ATCh hydrolysis and aggregation induced emission enhancement (AIEE). cadmium telluride 111-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 32478771-4 2020 The QDs successfully enabled the detection of low concentrations of AChE by turning on the fluorescence of the CdTe/CP via the interaction between CP and thiocholine produced by ATCh hydrolysis and aggregation induced emission enhancement (AIEE). Thiocholine 154-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 32478771-6 2020 More importantly, an efficient, inexpensive, and disposable paper-based platform, which allows the efficient visual detection of AChE activity via the color variation of CdTe/CP, was designed. cadmium telluride 170-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 32377662-1 2020 Rapid "in-field" detection of environmentally hazardous organophosphorus and nitro-containing pesticides is highly essential due to the lethal effects caused by the inhibition of the activity of acetylcholinesterase (AChE). organophosphorus 56-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-215 32377662-1 2020 Rapid "in-field" detection of environmentally hazardous organophosphorus and nitro-containing pesticides is highly essential due to the lethal effects caused by the inhibition of the activity of acetylcholinesterase (AChE). organophosphorus 56-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 217-221 32377662-1 2020 Rapid "in-field" detection of environmentally hazardous organophosphorus and nitro-containing pesticides is highly essential due to the lethal effects caused by the inhibition of the activity of acetylcholinesterase (AChE). nitro 77-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-215 32377662-1 2020 Rapid "in-field" detection of environmentally hazardous organophosphorus and nitro-containing pesticides is highly essential due to the lethal effects caused by the inhibition of the activity of acetylcholinesterase (AChE). nitro 77-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 217-221 32520690-9 2021 Molecular docking model for the most active molecule exhibited promising bindings with AChE and BChE"s active site pertained to hydrophobic hydrogen bonds and positive ionizable interactions. Hydrogen 140-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 32285537-0 2020 Sulfonamides incorporating ketene N,S-acetal bioisosteres as potent carbonic anhydrase and acetylcholinesterase inhibitors. Sulfonamides 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 32285537-0 2020 Sulfonamides incorporating ketene N,S-acetal bioisosteres as potent carbonic anhydrase and acetylcholinesterase inhibitors. ketene 27-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 32285537-0 2020 Sulfonamides incorporating ketene N,S-acetal bioisosteres as potent carbonic anhydrase and acetylcholinesterase inhibitors. n,s-acetal 34-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 32224335-3 2020 We identified that acetate moiety for inhibition of hCA I, hCA II, and alpha-glycosidase and dioxolane and thiocarbamic acid moieties for inhibition of AChE and BChE enzymes are very important. Acetates 19-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 32224335-3 2020 We identified that acetate moiety for inhibition of hCA I, hCA II, and alpha-glycosidase and dioxolane and thiocarbamic acid moieties for inhibition of AChE and BChE enzymes are very important. Carbamothioic acid 107-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 32184102-9 2020 Knockdown of ACHE was achieved by lipofectamine-mediated siRNA transfection and pharmaceutical suppression of ACHE was manipulated by donepezil. Lipofectamine 34-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 32184102-9 2020 Knockdown of ACHE was achieved by lipofectamine-mediated siRNA transfection and pharmaceutical suppression of ACHE was manipulated by donepezil. Donepezil 134-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 31617123-11 2020 Ethanol extract presented a strong inhibitory activity toward p38 and JNK3 MAPKs and AChE activity and also toward TNF-alpha release in human whole blood. Ethanol 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 32149402-6 2020 Interestingly, it has been found that TV 3326 (i.e. ladostigil) is regarded as a novel therapeutic agent since it has the potential to cause inhibition of monoamine oxidase (MAO) A and B, and acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in the brain. (N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate 38-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-212 32149402-6 2020 Interestingly, it has been found that TV 3326 (i.e. ladostigil) is regarded as a novel therapeutic agent since it has the potential to cause inhibition of monoamine oxidase (MAO) A and B, and acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in the brain. (N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate 38-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-218 32149402-6 2020 Interestingly, it has been found that TV 3326 (i.e. ladostigil) is regarded as a novel therapeutic agent since it has the potential to cause inhibition of monoamine oxidase (MAO) A and B, and acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in the brain. (N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate 52-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-212 32149402-6 2020 Interestingly, it has been found that TV 3326 (i.e. ladostigil) is regarded as a novel therapeutic agent since it has the potential to cause inhibition of monoamine oxidase (MAO) A and B, and acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in the brain. (N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate 52-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-218 32580406-4 2020 One of the identified hits, N,N-dimethyl-1-(4-(3-methyl-[1,2,4]triazolo[4,3-a]pyrimidin-6-yl)phenyl)ethan-1-amine (Y;mir-2), has dual-activity as an acetylcholinesterase (AChE) inhibitor and as an alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. n,n-dimethyl-1-(4-(3-methyl-[1,2,4]triazolo[4,3-a]pyrimidin-6-yl)phenyl)ethan-1-amine 28-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-169 32279763-1 2020 Herein we report a multiplated and biopolymeric-based optical bioassay for organophosphate detection based on the use of acetylcholinesterase (AChE) as biocomponent and biopolymeric electrospun fibrous mats as eco-designed supports for AChE immobilisation. Organophosphates 75-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 32279763-1 2020 Herein we report a multiplated and biopolymeric-based optical bioassay for organophosphate detection based on the use of acetylcholinesterase (AChE) as biocomponent and biopolymeric electrospun fibrous mats as eco-designed supports for AChE immobilisation. Organophosphates 75-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 236-240 32279763-2 2020 The principle of the detection relays on the decrease of enzymatic activity due to the capability of the organophosphorus pesticides to irreversibly inhibit AChE, which is optically detected using Ellman colorimetric method. organophosphorus 105-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 32006676-2 2020 The ACh concentration modulation is associated to the two major esterases, the acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Acetylcholine 4-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 32006676-2 2020 The ACh concentration modulation is associated to the two major esterases, the acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Acetylcholine 4-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 32006676-3 2020 AChE H353N protein polymorphism is related to low Chagas chronic disease prognostic. RU 353 5-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 32006676-4 2020 In order to evaluate the correlation of plasmatic BuChE concentration and the presence of AChE H353N polymorphism in Chagas disease patients and healthy individuals, we studied two groups of individuals, one of 61 Chagas disease patients and another of 74 healthy individuals. RU 353 95-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 32006676-5 2020 Plasma concentration of BuChE was measured by the chemiluminescent method and AChE H353N polymorphism was investigated by PCR-RFLP and sequencing of the respective encoding AChE gene fragment. RU 353 83-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 32200493-12 2020 CONCLUSIONS: Compounds possessing methylidenecyclohexanone scaffolds, with characteristic dual-binding and involving strong cation-pi interactions, serves as new leads for AChE and opens a new direction for drug discovery efforts. methylidenecyclohexanone 34-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-176 33488178-2 2020 Food and Drug Administration (FDA) approved drugs donepezil, rivastigmine, tacrine and galantamine are AChE inhibitors and in the treatment of Alzheimer"s disease (AD) these drugs are currently prescribed. Donepezil 50-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 33488178-2 2020 Food and Drug Administration (FDA) approved drugs donepezil, rivastigmine, tacrine and galantamine are AChE inhibitors and in the treatment of Alzheimer"s disease (AD) these drugs are currently prescribed. Rivastigmine 61-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 33488178-2 2020 Food and Drug Administration (FDA) approved drugs donepezil, rivastigmine, tacrine and galantamine are AChE inhibitors and in the treatment of Alzheimer"s disease (AD) these drugs are currently prescribed. Tacrine 75-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 33488178-2 2020 Food and Drug Administration (FDA) approved drugs donepezil, rivastigmine, tacrine and galantamine are AChE inhibitors and in the treatment of Alzheimer"s disease (AD) these drugs are currently prescribed. Galantamine 87-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 32486316-0 2020 Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer"s Disease Therapy. Quinolones 60-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32559640-4 2020 The eight compounds selected for the experimental study only 12b (effectiveness 68.54 +- 3.22%) was promising AChE inhibitor. 12b 61-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 32383693-14 2020 plicatum MeOH extract for hCAI, hCAII, AChE, BChE, and alpha-glycosidase were found to be 77.87, 52.90, 115.50, 117.46, and 81.53 mg/mL, respectively. Methanol 9-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 32546965-6 2020 Results: MG promoted alpha7nAChR expression in PBMCs both in vivo and in vitro, and inhibited the enzymatic activity of AChE simultaneously. mangostin 9-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 32443670-3 2020 Donepezil (DP) and rivastigmine tartrate (RT) are acetylcholinesterase (AChE) inhibitors and are used to treat symptomatic patients of mild to moderate AD. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 32443670-3 2020 Donepezil (DP) and rivastigmine tartrate (RT) are acetylcholinesterase (AChE) inhibitors and are used to treat symptomatic patients of mild to moderate AD. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 32443670-3 2020 Donepezil (DP) and rivastigmine tartrate (RT) are acetylcholinesterase (AChE) inhibitors and are used to treat symptomatic patients of mild to moderate AD. Donepezil 11-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 32443670-3 2020 Donepezil (DP) and rivastigmine tartrate (RT) are acetylcholinesterase (AChE) inhibitors and are used to treat symptomatic patients of mild to moderate AD. Donepezil 11-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 32443670-3 2020 Donepezil (DP) and rivastigmine tartrate (RT) are acetylcholinesterase (AChE) inhibitors and are used to treat symptomatic patients of mild to moderate AD. Rivastigmine 19-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 32443670-3 2020 Donepezil (DP) and rivastigmine tartrate (RT) are acetylcholinesterase (AChE) inhibitors and are used to treat symptomatic patients of mild to moderate AD. Rivastigmine 19-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 32443670-3 2020 Donepezil (DP) and rivastigmine tartrate (RT) are acetylcholinesterase (AChE) inhibitors and are used to treat symptomatic patients of mild to moderate AD. Rivastigmine 42-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 32443670-3 2020 Donepezil (DP) and rivastigmine tartrate (RT) are acetylcholinesterase (AChE) inhibitors and are used to treat symptomatic patients of mild to moderate AD. Rivastigmine 42-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 32443652-1 2020 Previously synthesized novel chalcone oxime ethers (COEs) were evaluated for inhibitory activities against monoamine oxidases (MAOs) and acetylcholinesterase (AChE). chalcone oxime ethers 29-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 32443652-1 2020 Previously synthesized novel chalcone oxime ethers (COEs) were evaluated for inhibitory activities against monoamine oxidases (MAOs) and acetylcholinesterase (AChE). chalcone oxime ethers 29-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 32443652-1 2020 Previously synthesized novel chalcone oxime ethers (COEs) were evaluated for inhibitory activities against monoamine oxidases (MAOs) and acetylcholinesterase (AChE). coes 52-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 32443652-1 2020 Previously synthesized novel chalcone oxime ethers (COEs) were evaluated for inhibitory activities against monoamine oxidases (MAOs) and acetylcholinesterase (AChE). coes 52-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 32278712-0 2020 Acylhydrazones as isoniazid derivatives with multi-target profiles for the treatment of Alzheimer"s disease: Radical scavenging, myeloperoxidase/acetylcholinesterase inhibition and biometal chelation. acylhydrazones 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 32278712-0 2020 Acylhydrazones as isoniazid derivatives with multi-target profiles for the treatment of Alzheimer"s disease: Radical scavenging, myeloperoxidase/acetylcholinesterase inhibition and biometal chelation. Isoniazid 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 32278712-1 2020 Acylhydrazones 1a-o, derived from isoniazid, were synthesized and evaluated for Myeloperoxidase (MPO) and Acetylcholinesterase (AChE) inhibition, as well as their antioxidant and metal chelating activities, with the purpose of investigating potential multi-target profiles for the treatment of Alzheimer"s disease. acylhydrazones 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 32414087-1 2020 The study documented here was aimed to find the molecular interactions of some of the cannabinoid constituents of cannabis with acetylcholinesterase (AChE). Cannabinoids 86-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 32414087-1 2020 The study documented here was aimed to find the molecular interactions of some of the cannabinoid constituents of cannabis with acetylcholinesterase (AChE). Cannabinoids 86-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 32414155-4 2020 The current AChE inhibitors (donepezil, rivastigmine, and galantamine) have short-acting mechanisms of action that result in dose-limiting toxicity and inadequate efficacy. Donepezil 29-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-16 32414155-4 2020 The current AChE inhibitors (donepezil, rivastigmine, and galantamine) have short-acting mechanisms of action that result in dose-limiting toxicity and inadequate efficacy. Rivastigmine 40-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-16 32414155-4 2020 The current AChE inhibitors (donepezil, rivastigmine, and galantamine) have short-acting mechanisms of action that result in dose-limiting toxicity and inadequate efficacy. Galantamine 58-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-16 32385098-0 2020 Correction: Rational design, synthesis, and evaluation of uncharged, "smart" bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase. bis-oxime 77-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-152 32385098-0 2020 Correction: Rational design, synthesis, and evaluation of uncharged, "smart" bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase. Organophosphates 100-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-152 32397331-0 2020 Patterned Superhydrophobic SERS Substrates for Sample Pre-Concentration and Demonstration of Its Utility through Monitoring of Inhibitory Effects of Paraoxon and Carbaryl on AChE. sers 27-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 32397331-0 2020 Patterned Superhydrophobic SERS Substrates for Sample Pre-Concentration and Demonstration of Its Utility through Monitoring of Inhibitory Effects of Paraoxon and Carbaryl on AChE. Paraoxon 149-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 32397331-0 2020 Patterned Superhydrophobic SERS Substrates for Sample Pre-Concentration and Demonstration of Its Utility through Monitoring of Inhibitory Effects of Paraoxon and Carbaryl on AChE. Carbaryl 162-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 32397331-7 2020 We demonstrate the utility of the patterned SERS substrate by evaluating the effects of inhibitors to acetylcholinesterase (AChE). sers 44-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 32397331-7 2020 We demonstrate the utility of the patterned SERS substrate by evaluating the effects of inhibitors to acetylcholinesterase (AChE). sers 44-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 32397331-9 2020 We monitored the enzymatic activity of AChE through the SERS spectrum of thiocholine (TC), the end product from acetylthiocholine (ATC). sers 56-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 32397331-9 2020 We monitored the enzymatic activity of AChE through the SERS spectrum of thiocholine (TC), the end product from acetylthiocholine (ATC). Thiocholine 73-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 32397331-9 2020 We monitored the enzymatic activity of AChE through the SERS spectrum of thiocholine (TC), the end product from acetylthiocholine (ATC). Thiocholine 86-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 32397331-9 2020 We monitored the enzymatic activity of AChE through the SERS spectrum of thiocholine (TC), the end product from acetylthiocholine (ATC). Acetylthiocholine 112-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 32580406-4 2020 One of the identified hits, N,N-dimethyl-1-(4-(3-methyl-[1,2,4]triazolo[4,3-a]pyrimidin-6-yl)phenyl)ethan-1-amine (Y;mir-2), has dual-activity as an acetylcholinesterase (AChE) inhibitor and as an alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. n,n-dimethyl-1-(4-(3-methyl-[1,2,4]triazolo[4,3-a]pyrimidin-6-yl)phenyl)ethan-1-amine 28-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 32397331-10 2020 Inhibitory effects of paraoxon and carbaryl on AChE were evaluated from the TC peak intensity. Paraoxon 22-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 32397331-10 2020 Inhibitory effects of paraoxon and carbaryl on AChE were evaluated from the TC peak intensity. Carbaryl 35-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 32397331-10 2020 Inhibitory effects of paraoxon and carbaryl on AChE were evaluated from the TC peak intensity. Thiocholine 76-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 32380126-3 2020 Oximes reactivate AChE in both the peripheral nervous system and the CNS. Oximes 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 32370238-4 2020 Moreover, in order to understand the mechanism, the binding interactions between coumarins and their targets: (i) AChE and (ii) Abeta1-42 peptide were investigated in silico. Coumarins 81-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 32370238-5 2020 All coumarins exhibited mild to moderate AChE and self-induced Abeta aggregation inhibitory actions. Coumarins 4-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 32370238-6 2020 In addition, the coumarins substituted with the long alkyl chain at position 6 or 8 illustrated ability to inhibit AChE-induced Abeta aggregation, resulting from their dual binding site at catalytic anionic site and peripheral active site in AChE. Coumarins 17-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 32370238-6 2020 In addition, the coumarins substituted with the long alkyl chain at position 6 or 8 illustrated ability to inhibit AChE-induced Abeta aggregation, resulting from their dual binding site at catalytic anionic site and peripheral active site in AChE. Coumarins 17-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 242-246 32155491-4 2020 Alkaloid isolation from root extract of Zanthoxylum rigidum was carried out using multi-step chromatography and TLC-bioautography against acetylcholinesterase (AChE) giving eight purified isoquinoline alkaloids. Alkaloids 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 32169593-1 2020 Based on structure analyses of butyrylcholinesterase (BChE), a series of 21 acridone glycosides were designed, synthesized and evaluated in vitro for their BChE and acetylcholinesterase (AChE) inhibitory activities. acridone glycosides 76-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-185 32169593-1 2020 Based on structure analyses of butyrylcholinesterase (BChE), a series of 21 acridone glycosides were designed, synthesized and evaluated in vitro for their BChE and acetylcholinesterase (AChE) inhibitory activities. acridone glycosides 76-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 32169593-2 2020 d-ribose derivative 6f exhibited the greatest inhibitory activity on BChE (IC50 = 6.95 muM), and was the most selective inhibitor of BChE with the IC50 ratio of AChE/BChE was 20.59. Ribose 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-165 32169593-3 2020 d-glucose and d-galactose derivatives 6a and 6b showed inhibitory activities against both AChE and BChE. Glucose 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 32169593-3 2020 d-glucose and d-galactose derivatives 6a and 6b showed inhibitory activities against both AChE and BChE. Galactose 14-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 31452424-6 2020 OpdA reduced blood OP insecticide concentration and acetylcholinesterase inhibition after poisoning by dimethoate, methyl parathion, and profenofos insecticides.Conclusions: In vitro incubation of OpdA in human serum showed hydrolysis of diverse OP insecticides, although at lower rates than found in buffer solutions. 1,2-diaminobenzene 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 31452424-6 2020 OpdA reduced blood OP insecticide concentration and acetylcholinesterase inhibition after poisoning by dimethoate, methyl parathion, and profenofos insecticides.Conclusions: In vitro incubation of OpdA in human serum showed hydrolysis of diverse OP insecticides, although at lower rates than found in buffer solutions. 1,2-diaminobenzene 197-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 31758986-2 2020 In combination with tetrameric acetylcholinesterase (AChE), a certain type of amplified acylhydrazone side chain is identified and further used for the synthesis of a multivalent AChE inhibitor. acylhydrazone 88-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 31758986-2 2020 In combination with tetrameric acetylcholinesterase (AChE), a certain type of amplified acylhydrazone side chain is identified and further used for the synthesis of a multivalent AChE inhibitor. acylhydrazone 88-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 31758986-2 2020 In combination with tetrameric acetylcholinesterase (AChE), a certain type of amplified acylhydrazone side chain is identified and further used for the synthesis of a multivalent AChE inhibitor. acylhydrazone 88-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 179-183 32348360-0 2020 Acetylcholinesterase electrochemical biosensors with graphene-transition metal carbides nanocomposites modified for detection of organophosphate pesticides. Graphite 53-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32348360-0 2020 Acetylcholinesterase electrochemical biosensors with graphene-transition metal carbides nanocomposites modified for detection of organophosphate pesticides. metal carbides 73-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32348360-0 2020 Acetylcholinesterase electrochemical biosensors with graphene-transition metal carbides nanocomposites modified for detection of organophosphate pesticides. Organophosphates 129-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32348360-1 2020 An acetylcholinesterase biosensor modified with graphene and transition metal carbides was prepared to detect organophosphorus pesticides. Graphite 48-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 3-23 32348360-1 2020 An acetylcholinesterase biosensor modified with graphene and transition metal carbides was prepared to detect organophosphorus pesticides. metal carbides 72-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 3-23 32348360-1 2020 An acetylcholinesterase biosensor modified with graphene and transition metal carbides was prepared to detect organophosphorus pesticides. organophosphorus 110-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 3-23 31692155-1 2020 Organophosphorus (OP)-based nerve agents are extremely toxic and potent acetylcholinesterase inhibitors and recent attacks involving nerve agents highlight the need for fast detection and intervention. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 32380126-6 2020 The aim of this study was to load AChE reactivator obidoxime chloride to PLGA and PEG-b-PLGA nanoparticles and to improve the BBB transport of the molecule. Obidoxime Chloride 51-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 32174113-2 2020 Donepezil is a well-known acetylcholinesterase inhibitor with its primary application being the treatment of Alzheimer"s disease. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 31955081-4 2020 When the AChE-AuNCs was applied to the proposed fluorescent detection, excellent sensitivity with wide linear range (50-1000 ng L-1) and low detection limit (30 ng L-1) for TClPP with the response time less than 1 h were achieved. N-trichloroacetyl-glucosamine 173-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 31837041-3 2020 In this study, a series of novel compounds based on tramiprosate, a highly specific amyloid beta (Abeta) inhibitor, was designed to inhibit AChE, BuChE, and Abeta aggregation. tramiprosate 52-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 31471933-1 2020 Based on the monoamine oxidase (MAO) inhibition properties of aminoheterocycles with a carbonitrile group we have carried out a systematic exploration to discover new classes of carbonitriles endowed with dual MAO and AChE inhibitory activities, and Abeta anti-aggregating properties. aminoheterocycles 62-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 218-222 31471933-1 2020 Based on the monoamine oxidase (MAO) inhibition properties of aminoheterocycles with a carbonitrile group we have carried out a systematic exploration to discover new classes of carbonitriles endowed with dual MAO and AChE inhibitory activities, and Abeta anti-aggregating properties. carbonitriles 178-191 acetylcholinesterase (Cartwright blood group) Homo sapiens 218-222 32290125-1 2020 Chlorpyrifos, an acetylcholinesterase inhibitor (ACI), is one of the most widely used insecticides in the world, and is generally recognized to be a moderate human neurotoxin. Chlorpyrifos 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 32105080-1 2020 The acetylcholinesterase (AChE) inhibitor, acotiamide, improves gastric motility, and is clinically used to treat functional dyspepsia. Z 338 43-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 32105080-1 2020 The acetylcholinesterase (AChE) inhibitor, acotiamide, improves gastric motility, and is clinically used to treat functional dyspepsia. Z 338 43-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 32105443-2 2020 Oxime reactivators of AChE are used in medical practice in the treatment of nerve agent poisoning, but the search for novel improved reactivators with central activity is an ongoing pursuit. Oximes 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 32105443-4 2020 This study reports a comprehensive physicochemical, pharmacokinetic, and safety profiling of five lipophilic 3-hydroxy-2-pyridine aldoximes, which were recently shown to be potent AChE reactivators with a potential to be centrally active. 3-hydroxy-2-pyridine 109-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 31841723-9 2020 Acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and 3,5,6-trichloro-2-pyridinol (TCP-y), specific for Chlorpyrifos, were among the most common biomarkers identified; however, most metabolites found were non-specific. Chlorpyrifos 113-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 31841723-9 2020 Acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and 3,5,6-trichloro-2-pyridinol (TCP-y), specific for Chlorpyrifos, were among the most common biomarkers identified; however, most metabolites found were non-specific. Chlorpyrifos 113-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 31411109-9 2020 The use of neostigmine as a continuous subcutaneous infusion may have a role in the management of such patients, particularly when enteral administration of acetylcholinesterase inhibitors is no longer possible. Neostigmine 11-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-177 32088494-0 2020 Design, synthesis and biological evaluation of 2,3-dihydro-5,6-dimethoxy-1H-inden-1-one and piperazinium salt hybrid derivatives as hAChE and hBuChE enzyme inhibitors. 2,3-dihydro-5,6-dimethoxy-1h-inden-1-one 47-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-137 32088494-0 2020 Design, synthesis and biological evaluation of 2,3-dihydro-5,6-dimethoxy-1H-inden-1-one and piperazinium salt hybrid derivatives as hAChE and hBuChE enzyme inhibitors. piperazinium salt 92-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-137 31096863-6 2020 While the enzyme action is sensed by interacted species of NGQDs and acetylcholine, the fluorescence of NGQDs is quenched by the hydrolyzing action of acetylcholinesterase (AChE) enzyme but the lost fluorescence is recovered upon addition of anti-AD drugs. Acetylcholine 69-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-171 31096863-6 2020 While the enzyme action is sensed by interacted species of NGQDs and acetylcholine, the fluorescence of NGQDs is quenched by the hydrolyzing action of acetylcholinesterase (AChE) enzyme but the lost fluorescence is recovered upon addition of anti-AD drugs. Acetylcholine 69-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-177 31997357-5 2020 The "-CDOCKER_Energy" value of the best docking position of the tripeptide IEK, LYR and CIK interacting with acetylcholinesterase (AChE) were - 93.8119, -86.9556 and - 73.6370 kcal/mol, respectively. tripeptide K-26 64-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 31997357-10 2020 CONCLUSION: Tripeptide CIK can effectively inhibit the activities of AChE, BChE and BACE1. tripeptide K-26 12-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 31636242-1 2020 Background: Acetylcholinesterase inhibitors (e.g., pyridostigmine bromide) are used for neuromuscular blockade (NMB) reversal in patients undergoing surgery under general anesthesia (GA). Pyridostigmine Bromide 51-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 31954292-10 2020 While all the phytochemicals showed potential in inhibiting the enzymes, Rutin, Demethoxycurcumin and Acteoside were found to be most effective inhibitors of MAO-B, COMT and AChE respectively. Rutin 73-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 31954292-10 2020 While all the phytochemicals showed potential in inhibiting the enzymes, Rutin, Demethoxycurcumin and Acteoside were found to be most effective inhibitors of MAO-B, COMT and AChE respectively. demethoxycurcumin 80-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 31954292-10 2020 While all the phytochemicals showed potential in inhibiting the enzymes, Rutin, Demethoxycurcumin and Acteoside were found to be most effective inhibitors of MAO-B, COMT and AChE respectively. acteoside 102-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 31853730-1 2020 The level of acetylcholine, a neurotransmitter essential for processing memory and learning, is lower in the brains of patients with Alzheimer"s disease due to the higher concentration of the enzyme acetylcholinesterase. Acetylcholine 13-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-219 32317886-2 2020 Even intermediate-acting NMBAs may have a prolonged effect resulting in residual weakness after reversal with acetylcholinesterase inhibitors (neostigmine). Neostigmine 143-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 32019865-0 2020 Rational design, synthesis and evaluation of uncharged, "smart" bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase. Oximes 64-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 32019865-0 2020 Rational design, synthesis and evaluation of uncharged, "smart" bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase. Organophosphates 87-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 32019865-5 2020 On the basis of X-ray structures of a CNS-penetrating reactivator, monoxime RS194B, reversibly bound to native and venomous agent X (VX)-inhibited human AChE (hAChE), here we created seven uncharged acetamido bis-oximes as candidate antidotes. RS194B 67-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 32019865-5 2020 On the basis of X-ray structures of a CNS-penetrating reactivator, monoxime RS194B, reversibly bound to native and venomous agent X (VX)-inhibited human AChE (hAChE), here we created seven uncharged acetamido bis-oximes as candidate antidotes. Oximes 199-219 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 32193421-8 2020 Taken together, our results show that IGFBP-3 or its peptide blocks hyaluronan-CD44 signaling via a mechanism that depends on both p53 and acetylcholinesterase. Hyaluronic Acid 68-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-159 32031197-0 2020 Acetylcholinesterase-catalyzed silver deposition for ultrasensitive electrochemical biosensing of organophosphorus pesticides. Silver 31-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32031197-0 2020 Acetylcholinesterase-catalyzed silver deposition for ultrasensitive electrochemical biosensing of organophosphorus pesticides. Organophosphates 98-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32031197-1 2020 Herein, an electrochemical biosensing platform with acetylcholinesterase (AChE)-catalyzed silver deposition was developed for the ultrasensitive detection of organophosphorus pesticides (OPs). Silver 90-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 32031197-1 2020 Herein, an electrochemical biosensing platform with acetylcholinesterase (AChE)-catalyzed silver deposition was developed for the ultrasensitive detection of organophosphorus pesticides (OPs). Silver 90-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 32031197-1 2020 Herein, an electrochemical biosensing platform with acetylcholinesterase (AChE)-catalyzed silver deposition was developed for the ultrasensitive detection of organophosphorus pesticides (OPs). Organophosphates 158-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 32031197-1 2020 Herein, an electrochemical biosensing platform with acetylcholinesterase (AChE)-catalyzed silver deposition was developed for the ultrasensitive detection of organophosphorus pesticides (OPs). Organophosphates 158-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 32031197-2 2020 The biosensing mechanism is based on the fact that AChE can catalyze the rapid hydrolysis of indoxyl acetate to form hydroxyindole, which in turn reduces silver ions to metallic silver, resulting in the deposition of silver on the gold electrode. indoxyl acetate 93-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 32031197-2 2020 The biosensing mechanism is based on the fact that AChE can catalyze the rapid hydrolysis of indoxyl acetate to form hydroxyindole, which in turn reduces silver ions to metallic silver, resulting in the deposition of silver on the gold electrode. 3-hydroxyindole 117-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 32031197-2 2020 The biosensing mechanism is based on the fact that AChE can catalyze the rapid hydrolysis of indoxyl acetate to form hydroxyindole, which in turn reduces silver ions to metallic silver, resulting in the deposition of silver on the gold electrode. Silver 154-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 32031197-2 2020 The biosensing mechanism is based on the fact that AChE can catalyze the rapid hydrolysis of indoxyl acetate to form hydroxyindole, which in turn reduces silver ions to metallic silver, resulting in the deposition of silver on the gold electrode. Silver 178-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 32031197-2 2020 The biosensing mechanism is based on the fact that AChE can catalyze the rapid hydrolysis of indoxyl acetate to form hydroxyindole, which in turn reduces silver ions to metallic silver, resulting in the deposition of silver on the gold electrode. Silver 178-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 32031197-4 2020 Due to its lower oxidation potential under facile conditions with a relatively sharp peak, a small amount of deposited silver generated from AChE-catalysis could result in a significant change in the LSV response. Silver 119-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 32031197-5 2020 In the presence of OPs, the AChE-catalyzed hydrolysis of indoxyl acetate is blocked, and then the silver deposition on the gold electrode declines, leading to a remarkable decrease in the LSV response and, thus producing a large signal output for the ultrasensitive detection of chlorpyrifos, a proof-of-concept OP in this work. indoxyl acetate 57-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 32031197-5 2020 In the presence of OPs, the AChE-catalyzed hydrolysis of indoxyl acetate is blocked, and then the silver deposition on the gold electrode declines, leading to a remarkable decrease in the LSV response and, thus producing a large signal output for the ultrasensitive detection of chlorpyrifos, a proof-of-concept OP in this work. Silver 98-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 32031197-5 2020 In the presence of OPs, the AChE-catalyzed hydrolysis of indoxyl acetate is blocked, and then the silver deposition on the gold electrode declines, leading to a remarkable decrease in the LSV response and, thus producing a large signal output for the ultrasensitive detection of chlorpyrifos, a proof-of-concept OP in this work. Chlorpyrifos 279-291 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 32031197-7 2020 To the best of our knowledge, this is the first example of a biosensing platform for ultrasensitive OP assay using AChE-controlled silver deposition to enhance the output of electronic signals. Silver 131-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 32155927-2 2020 Acetylcholinesterase (AChE) plays a significant role in the process through hydrolysis of the acetylcholine neurotransmitter. Acetylcholine 94-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32035286-9 2020 Showing that these Cu-based compounds can act as new allosteric inhibitors of AChE and identifying novel allosteric binding site on AChE represents a significant contribution toward the design of novel and more effective inhibitors of AChE. Copper 19-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 32035286-9 2020 Showing that these Cu-based compounds can act as new allosteric inhibitors of AChE and identifying novel allosteric binding site on AChE represents a significant contribution toward the design of novel and more effective inhibitors of AChE. Copper 19-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 32035286-9 2020 Showing that these Cu-based compounds can act as new allosteric inhibitors of AChE and identifying novel allosteric binding site on AChE represents a significant contribution toward the design of novel and more effective inhibitors of AChE. Copper 19-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 32008906-0 2020 Design, synthesis and evaluation of new 4-arylthiazole-2-amine derivatives as acetylcholinesterase inhibitors. Amines 40-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 32008906-1 2020 A series of new 4-arylthiazole-2-amine derivatives as acetylcholinesterase inhibitors (AChEIs) were designed and synthesized, Furthermore, their inhibitory activities against acetylcholinesterase in vitro were tested by Ellman spectrophotometry, and the results of inhibitory activity test showed that most of them had a certain acetylcholinesterase inhibitory activity in vitro. Amines 16-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 32008906-1 2020 A series of new 4-arylthiazole-2-amine derivatives as acetylcholinesterase inhibitors (AChEIs) were designed and synthesized, Furthermore, their inhibitory activities against acetylcholinesterase in vitro were tested by Ellman spectrophotometry, and the results of inhibitory activity test showed that most of them had a certain acetylcholinesterase inhibitory activity in vitro. Amines 16-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 175-195 32008906-1 2020 A series of new 4-arylthiazole-2-amine derivatives as acetylcholinesterase inhibitors (AChEIs) were designed and synthesized, Furthermore, their inhibitory activities against acetylcholinesterase in vitro were tested by Ellman spectrophotometry, and the results of inhibitory activity test showed that most of them had a certain acetylcholinesterase inhibitory activity in vitro. Amines 16-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 175-195 31830555-1 2020 Nerve agents inhibit acetylcholinesterase (AChE), leading to a build-up of acetylcholine (ACh) and overstimulation at cholinergic synapses. Acetylcholine 21-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 31830555-1 2020 Nerve agents inhibit acetylcholinesterase (AChE), leading to a build-up of acetylcholine (ACh) and overstimulation at cholinergic synapses. Acetylcholine 43-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 31830555-2 2020 Current post-exposure nerve agent treatment includes atropine to treat overstimulation at muscarinic synapses, a benzodiazepine anti-convulsant, and an oxime to restore the function of AChE. Oximes 152-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 185-189 32163499-1 2020 Organophosphates (OPs) induce acute and chronic neurotoxicity, primarily by inhibiting acetylcholinesterase (AChE) activity as well as by necrosis, and apoptosis. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 32163499-1 2020 Organophosphates (OPs) induce acute and chronic neurotoxicity, primarily by inhibiting acetylcholinesterase (AChE) activity as well as by necrosis, and apoptosis. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 32163499-1 2020 Organophosphates (OPs) induce acute and chronic neurotoxicity, primarily by inhibiting acetylcholinesterase (AChE) activity as well as by necrosis, and apoptosis. Organophosphates 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 32163499-1 2020 Organophosphates (OPs) induce acute and chronic neurotoxicity, primarily by inhibiting acetylcholinesterase (AChE) activity as well as by necrosis, and apoptosis. Organophosphates 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 32086265-2 2020 As organophosphorus (OP) pesticide poisoning exerts the same pathomechanism, that is, inhibition of the pivotal enzyme acetylcholinesterase (AChE), a portable cholinesterase (ChE) test kit was applied in an emergency room for rapid diagnosis of OP poisoning. organophosphorus 3-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 32086265-2 2020 As organophosphorus (OP) pesticide poisoning exerts the same pathomechanism, that is, inhibition of the pivotal enzyme acetylcholinesterase (AChE), a portable cholinesterase (ChE) test kit was applied in an emergency room for rapid diagnosis of OP poisoning. organophosphorus 3-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 32086265-8 2020 In one case report, AChE activity increased after oxime administration indicating therapeutic success whereas BChE activity did not. Oximes 50-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 32086265-10 2020 As inhibition of AChE or BChE activity is determined, the CE-certified device is a global diagnostic tool for all ChE inhibitors including carbamates which might also be misused as chemical weapon. Carbamates 139-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 32155927-2 2020 Acetylcholinesterase (AChE) plays a significant role in the process through hydrolysis of the acetylcholine neurotransmitter. Acetylcholine 94-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 32032848-0 2020 Tacrine-xanomeline and tacrine-iperoxo hybrid ligands: Synthesis and biological evaluation at acetylcholinesterase and M1 muscarinic acetylcholine receptors. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 32178264-4 2020 Within the most outstanding reactivators, the substances denominated oximes stand out, showing good performance for reactivating AChE and restoring the normal synaptic acetylcholine (ACh) levels. Oximes 69-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 31978679-3 2020 Compounds 4ah and 4bh proved to be more potent than the standard drug tacrine, rivastigmine and galantamine for AChE inhibition activity with IC50 value between 0.055 +- 0.143 microM and 0.017 +- 0.02 microM respectively. CHEMBL206467 10-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 31978679-3 2020 Compounds 4ah and 4bh proved to be more potent than the standard drug tacrine, rivastigmine and galantamine for AChE inhibition activity with IC50 value between 0.055 +- 0.143 microM and 0.017 +- 0.02 microM respectively. 4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 31978679-3 2020 Compounds 4ah and 4bh proved to be more potent than the standard drug tacrine, rivastigmine and galantamine for AChE inhibition activity with IC50 value between 0.055 +- 0.143 microM and 0.017 +- 0.02 microM respectively. Tacrine 70-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 31978679-3 2020 Compounds 4ah and 4bh proved to be more potent than the standard drug tacrine, rivastigmine and galantamine for AChE inhibition activity with IC50 value between 0.055 +- 0.143 microM and 0.017 +- 0.02 microM respectively. Rivastigmine 79-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 31978679-3 2020 Compounds 4ah and 4bh proved to be more potent than the standard drug tacrine, rivastigmine and galantamine for AChE inhibition activity with IC50 value between 0.055 +- 0.143 microM and 0.017 +- 0.02 microM respectively. Galantamine 96-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 32032848-0 2020 Tacrine-xanomeline and tacrine-iperoxo hybrid ligands: Synthesis and biological evaluation at acetylcholinesterase and M1 muscarinic acetylcholine receptors. Tacrine 23-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 32032848-2 2020 When tested in vitro in a colorimetric assay for their ability to inhibit AChE, the new compounds showed higher or similar potency compared to that of tacrine. Tacrine 151-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 32032848-5 2020 The results were compared with those obtained on the known derivatives 6-C7 and 6-C10, two quite potent AChE inhibitors in which tacrine is linked to iperoxo, an exceptionally potent muscarinic orthosteric activator. 6-c7 71-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 32032848-5 2020 The results were compared with those obtained on the known derivatives 6-C7 and 6-C10, two quite potent AChE inhibitors in which tacrine is linked to iperoxo, an exceptionally potent muscarinic orthosteric activator. 6-c10 80-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 31968151-0 2020 Organocatalyzed solvent free and efficient synthesis of 2,4,5-trisubstituted imidazoles as potential acetylcholinesterase inhibitors for Alzheimer"s disease. imidazole 56-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 32032848-5 2020 The results were compared with those obtained on the known derivatives 6-C7 and 6-C10, two quite potent AChE inhibitors in which tacrine is linked to iperoxo, an exceptionally potent muscarinic orthosteric activator. Tacrine 129-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 32058104-0 2020 Synthesis, structure elucidation, and in vitro pharmacological evaluation of novel polyfluoro substituted pyrazoline type sulfonamides as multi-target agents for inhibition of acetylcholinesterase and carbonic anhydrase I and II enzymes. N-substituted Glycines 83-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-196 32058104-0 2020 Synthesis, structure elucidation, and in vitro pharmacological evaluation of novel polyfluoro substituted pyrazoline type sulfonamides as multi-target agents for inhibition of acetylcholinesterase and carbonic anhydrase I and II enzymes. Sulfonamides 122-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-196 32058104-1 2020 A novel series of 4-(3-(difluorophenyl)-5-(dimethoxyphenyl)-4,5-dihydropyrazol-1-yl)benzenesulfonamides 1-8 were designed since sulfonamide and pyrazoline pharmacophores draw great attention in novel drug design due to their wide range of bioactivities including acetylcholinesterase (AChE) and human carbonic anhydrase I and II (hCA I and hCA II) inhibitory potencies. (N-(2-(3,4-dimethoxyphenyl)ethyl)-benzenesulfonamide) 18-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 263-283 32058104-1 2020 A novel series of 4-(3-(difluorophenyl)-5-(dimethoxyphenyl)-4,5-dihydropyrazol-1-yl)benzenesulfonamides 1-8 were designed since sulfonamide and pyrazoline pharmacophores draw great attention in novel drug design due to their wide range of bioactivities including acetylcholinesterase (AChE) and human carbonic anhydrase I and II (hCA I and hCA II) inhibitory potencies. (N-(2-(3,4-dimethoxyphenyl)ethyl)-benzenesulfonamide) 18-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 285-289 32058104-1 2020 A novel series of 4-(3-(difluorophenyl)-5-(dimethoxyphenyl)-4,5-dihydropyrazol-1-yl)benzenesulfonamides 1-8 were designed since sulfonamide and pyrazoline pharmacophores draw great attention in novel drug design due to their wide range of bioactivities including acetylcholinesterase (AChE) and human carbonic anhydrase I and II (hCA I and hCA II) inhibitory potencies. Sulfonamides 91-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 263-283 32058104-1 2020 A novel series of 4-(3-(difluorophenyl)-5-(dimethoxyphenyl)-4,5-dihydropyrazol-1-yl)benzenesulfonamides 1-8 were designed since sulfonamide and pyrazoline pharmacophores draw great attention in novel drug design due to their wide range of bioactivities including acetylcholinesterase (AChE) and human carbonic anhydrase I and II (hCA I and hCA II) inhibitory potencies. Sulfonamides 91-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 285-289 32092302-3 2020 Rivastigmine is one of the most widely used AChE inhibitors. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 31968151-4 2020 Among this series of compounds 3m bearing one ethoxy and a hydroxyl group on the phenyl ring on 2,4,5-trisubstituted imidazoles proved potent AChE inhibitor (102.56+-0.14). Hydroxyl Radical 59-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 31968151-4 2020 Among this series of compounds 3m bearing one ethoxy and a hydroxyl group on the phenyl ring on 2,4,5-trisubstituted imidazoles proved potent AChE inhibitor (102.56+-0.14). TAT 59 81-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 31968151-4 2020 Among this series of compounds 3m bearing one ethoxy and a hydroxyl group on the phenyl ring on 2,4,5-trisubstituted imidazoles proved potent AChE inhibitor (102.56+-0.14). imidazole 96-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 32118214-1 2020 In this study, demethylcurcumin (DC), a minor constituent in curcuminoids, showed better anti-acetylcholinesterase (anti-AChE) activities, anti-amyloid beta peptide aggregation, neuroprotective activities in 6-hydroxydopamine-treated SH-SY5Y cell models, and anti-nitric oxide production in lipopolysaccharide-treated RAW 264.7 macrophages than those of curcumin. Curcumin 23-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 32118214-1 2020 In this study, demethylcurcumin (DC), a minor constituent in curcuminoids, showed better anti-acetylcholinesterase (anti-AChE) activities, anti-amyloid beta peptide aggregation, neuroprotective activities in 6-hydroxydopamine-treated SH-SY5Y cell models, and anti-nitric oxide production in lipopolysaccharide-treated RAW 264.7 macrophages than those of curcumin. Curcumin 23-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 32118214-2 2020 Based on molecular docking analyses with AChE, the meta-hydroxyl group in DC, nonexistent in curcumin, showed the formation of hydrogen bonds with Ser293 and Tyr341 in the binding sites of AChE. Deoxycytidine 74-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 32118214-2 2020 Based on molecular docking analyses with AChE, the meta-hydroxyl group in DC, nonexistent in curcumin, showed the formation of hydrogen bonds with Ser293 and Tyr341 in the binding sites of AChE. Deoxycytidine 74-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-193 32118214-2 2020 Based on molecular docking analyses with AChE, the meta-hydroxyl group in DC, nonexistent in curcumin, showed the formation of hydrogen bonds with Ser293 and Tyr341 in the binding sites of AChE. Hydrogen 127-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 32118214-2 2020 Based on molecular docking analyses with AChE, the meta-hydroxyl group in DC, nonexistent in curcumin, showed the formation of hydrogen bonds with Ser293 and Tyr341 in the binding sites of AChE. Hydrogen 127-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-193 31883448-3 2020 Acetylcholinesterase activity was increased, while Na+, K+-ATPase activity was decreased by 2 mM Met, Met-SO, or Met (1 and 2 mM) + Met-SO (P < 0.05). bis-(3-(3',5'-di-tert-butyl-4'-hydroxyphenyl)propyl)sulfide 136-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 31879781-3 2020 Disruption of cholinergic function through the inhibition of acetylcholinesterase (AChE) leads to the accumulation of the neurotransmitter acetylcholine. Acetylcholine 61-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 31879781-5 2020 The primary therapeutic strategy employed in the U.S. to treat OP intoxication includes reactivation of inhibited AChE with the oxime pralidoxime (2-PAM) along with the muscarinic acetylcholine receptor antagonist atropine and the benzodiazepine, diazepam. pralidoxime 128-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 31879781-5 2020 The primary therapeutic strategy employed in the U.S. to treat OP intoxication includes reactivation of inhibited AChE with the oxime pralidoxime (2-PAM) along with the muscarinic acetylcholine receptor antagonist atropine and the benzodiazepine, diazepam. Pralidoxime Compounds 147-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 32053129-5 2020 Under the catalysis of acetylcholinesterase (AChE) and choline oxidase (CHO), H2O2 was produced by using acetylcholine chloride (ACh) as a substrate, which was sensitive to the proposed CL system. Choline 29-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 32276912-3 2020 On the basis of this approach in-house library of 9-aminoacridine derivatives were constructed and allowed to docked against human acetylcholinesterase (hAChE) (PDB ID: 4EY7), using MOE 2018.01 and PyRx 0.9.2 (AutoDock Vina). Aminacrine 50-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-151 32276912-3 2020 On the basis of this approach in-house library of 9-aminoacridine derivatives were constructed and allowed to docked against human acetylcholinesterase (hAChE) (PDB ID: 4EY7), using MOE 2018.01 and PyRx 0.9.2 (AutoDock Vina). Aminacrine 50-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-158 32023409-2 2020 In the investigation, we designed and prepared several new glycine amide derivatives of Sanger"s reagent and demonstrated that they serve as a new class of photocages for Zn2+ and an acetylcholinesterase (AChE) inhibitor. glycine amide 59-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-203 32023409-2 2020 In the investigation, we designed and prepared several new glycine amide derivatives of Sanger"s reagent and demonstrated that they serve as a new class of photocages for Zn2+ and an acetylcholinesterase (AChE) inhibitor. glycine amide 59-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 205-209 32175496-0 2020 Molecular Modeling Study of Uncharged Oximes Compared to HI-6 and 2-PAM Inside Human AChE Sarin and VX Conjugates. Oximes 38-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 32175496-3 2020 HI-6 and 2-PAM are cationic oximes proved to be effective for the reactivation of AChE inhibited by the nerve agents VX and sarin (GB). asoxime chloride 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 32175496-3 2020 HI-6 and 2-PAM are cationic oximes proved to be effective for the reactivation of AChE inhibited by the nerve agents VX and sarin (GB). Oximes 28-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 32053129-5 2020 Under the catalysis of acetylcholinesterase (AChE) and choline oxidase (CHO), H2O2 was produced by using acetylcholine chloride (ACh) as a substrate, which was sensitive to the proposed CL system. Water 78-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 32053129-5 2020 Under the catalysis of acetylcholinesterase (AChE) and choline oxidase (CHO), H2O2 was produced by using acetylcholine chloride (ACh) as a substrate, which was sensitive to the proposed CL system. Water 78-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 32053129-5 2020 Under the catalysis of acetylcholinesterase (AChE) and choline oxidase (CHO), H2O2 was produced by using acetylcholine chloride (ACh) as a substrate, which was sensitive to the proposed CL system. Acetylcholine 105-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 32053129-5 2020 Under the catalysis of acetylcholinesterase (AChE) and choline oxidase (CHO), H2O2 was produced by using acetylcholine chloride (ACh) as a substrate, which was sensitive to the proposed CL system. Acetylcholine 105-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 32053129-5 2020 Under the catalysis of acetylcholinesterase (AChE) and choline oxidase (CHO), H2O2 was produced by using acetylcholine chloride (ACh) as a substrate, which was sensitive to the proposed CL system. Acetylcholine 45-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 31996889-1 2020 A thermoresponsive NIPAAm-based polymer is combined with the selective acetylcholinesterase inhibitor tacrine in order to create a strict in sense on/off switch for enzymatic activity. poly(NIPAAm-co-FL) 19-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 31996889-1 2020 A thermoresponsive NIPAAm-based polymer is combined with the selective acetylcholinesterase inhibitor tacrine in order to create a strict in sense on/off switch for enzymatic activity. Tacrine 102-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 32098407-2 2020 Among the DNP-BIM hybrids studied herein, the structural isomerization did not significantly improve the biological properties, while some substitutions, namely fluorine atom in each moiety or the methoxy group in the benzyl ring, evidenced higher cholinergic AChE activity. Donepezil 10-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 260-264 32058974-3 2020 Posiphen, a stereoisomer of the AChE inhibitor Phenserine, lacks AChE inhibitor activity. phenserine 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 32058974-3 2020 Posiphen, a stereoisomer of the AChE inhibitor Phenserine, lacks AChE inhibitor activity. phenserine 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 32058974-3 2020 Posiphen, a stereoisomer of the AChE inhibitor Phenserine, lacks AChE inhibitor activity. phenserine 47-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 31983197-0 2020 Colorimetric Differentiation of Flavonoids Based on Effective Reactivation of Acetylcholinesterase Induced by Different Affnities between Flavonoids and Metal Ions. Flavonoids 32-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 32118214-1 2020 In this study, demethylcurcumin (DC), a minor constituent in curcuminoids, showed better anti-acetylcholinesterase (anti-AChE) activities, anti-amyloid beta peptide aggregation, neuroprotective activities in 6-hydroxydopamine-treated SH-SY5Y cell models, and anti-nitric oxide production in lipopolysaccharide-treated RAW 264.7 macrophages than those of curcumin. Monodemethylcurcumin 15-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 32118214-1 2020 In this study, demethylcurcumin (DC), a minor constituent in curcuminoids, showed better anti-acetylcholinesterase (anti-AChE) activities, anti-amyloid beta peptide aggregation, neuroprotective activities in 6-hydroxydopamine-treated SH-SY5Y cell models, and anti-nitric oxide production in lipopolysaccharide-treated RAW 264.7 macrophages than those of curcumin. Monodemethylcurcumin 15-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 32118214-1 2020 In this study, demethylcurcumin (DC), a minor constituent in curcuminoids, showed better anti-acetylcholinesterase (anti-AChE) activities, anti-amyloid beta peptide aggregation, neuroprotective activities in 6-hydroxydopamine-treated SH-SY5Y cell models, and anti-nitric oxide production in lipopolysaccharide-treated RAW 264.7 macrophages than those of curcumin. Deoxycytidine 33-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 32118214-1 2020 In this study, demethylcurcumin (DC), a minor constituent in curcuminoids, showed better anti-acetylcholinesterase (anti-AChE) activities, anti-amyloid beta peptide aggregation, neuroprotective activities in 6-hydroxydopamine-treated SH-SY5Y cell models, and anti-nitric oxide production in lipopolysaccharide-treated RAW 264.7 macrophages than those of curcumin. Deoxycytidine 33-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 31983197-0 2020 Colorimetric Differentiation of Flavonoids Based on Effective Reactivation of Acetylcholinesterase Induced by Different Affnities between Flavonoids and Metal Ions. Flavonoids 138-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 31983197-0 2020 Colorimetric Differentiation of Flavonoids Based on Effective Reactivation of Acetylcholinesterase Induced by Different Affnities between Flavonoids and Metal Ions. Metals 153-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 31767347-6 2020 In the presence of OPs, the ECL signal obviously increased because the enzyme activity of the acetylcholinesterase (AChE) was inhibited by OPs. Organophosphates 19-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 31901380-0 2020 Selective acetylcholinesterase inhibitors derived from muscle relaxant dantrolene. Dantrolene 71-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-30 31901380-2 2020 Recently, it has been reported that dantrolene has a weak inhibitory effect on acetylcholinesterase (AChE), which is a therapeutic drug target for Alzheimer"s disease. Dantrolene 36-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 31901380-2 2020 Recently, it has been reported that dantrolene has a weak inhibitory effect on acetylcholinesterase (AChE), which is a therapeutic drug target for Alzheimer"s disease. Dantrolene 36-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 31901380-3 2020 Thus, we focused on developing of AChE inhibitors with benzylpiperidine/piperazine moieties that are based on the dantrolene skeleton. 1-benzylpiperidine 55-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 31901380-3 2020 Thus, we focused on developing of AChE inhibitors with benzylpiperidine/piperazine moieties that are based on the dantrolene skeleton. piperazine 72-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 31901380-3 2020 Thus, we focused on developing of AChE inhibitors with benzylpiperidine/piperazine moieties that are based on the dantrolene skeleton. Dantrolene 114-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 31901382-2 2020 In vitro studies showed all xanthone derivatives had good metal chelating property and exhibited selective inhibitory activity against Acetylcholinesterase (AChE). xanthone 28-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 31901382-2 2020 In vitro studies showed all xanthone derivatives had good metal chelating property and exhibited selective inhibitory activity against Acetylcholinesterase (AChE). xanthone 28-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 31901382-6 2020 Furthermore, copper complex had higher anti-AChE activity and antioxidant activity. Copper 13-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 32175496-5 2020 Uncharged oximes appear as an interesting alternative to solve this problem, but the development and enhancement of more efficient uncharged oximes capable of reactivating human AChE is still necessary. Oximes 10-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-182 32175496-5 2020 Uncharged oximes appear as an interesting alternative to solve this problem, but the development and enhancement of more efficient uncharged oximes capable of reactivating human AChE is still necessary. Oximes 141-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-182 32175496-8 2020 The uncharged oximes showed different behaviors, especially RS194B, which presented stability inside AChE-VX, but presented free binding energy lower than cationic oximes, suggesting that structural alterations could favor its interactions with these complexes. Oximes 14-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 32175496-9 2020 In contrast, HI-6 and 2-PAM showed higher affinities with more negative binding energy values and larger contribution of the amino acid Asp74, demonstrating the importance of the quaternary nitrogen to the affinity and interaction of oximes with AChE-GB and AChE-VX conjugates. asoxime chloride 13-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 246-250 32175496-9 2020 In contrast, HI-6 and 2-PAM showed higher affinities with more negative binding energy values and larger contribution of the amino acid Asp74, demonstrating the importance of the quaternary nitrogen to the affinity and interaction of oximes with AChE-GB and AChE-VX conjugates. Nitrogen 190-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 246-250 32175496-9 2020 In contrast, HI-6 and 2-PAM showed higher affinities with more negative binding energy values and larger contribution of the amino acid Asp74, demonstrating the importance of the quaternary nitrogen to the affinity and interaction of oximes with AChE-GB and AChE-VX conjugates. Oximes 234-240 acetylcholinesterase (Cartwright blood group) Homo sapiens 246-250 31767347-6 2020 In the presence of OPs, the ECL signal obviously increased because the enzyme activity of the acetylcholinesterase (AChE) was inhibited by OPs. Organophosphates 19-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 31767347-6 2020 In the presence of OPs, the ECL signal obviously increased because the enzyme activity of the acetylcholinesterase (AChE) was inhibited by OPs. Organophosphates 139-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 31767347-6 2020 In the presence of OPs, the ECL signal obviously increased because the enzyme activity of the acetylcholinesterase (AChE) was inhibited by OPs. Organophosphates 139-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 32055740-8 2020 In addition, the expression of some genes involved in cell cycle, protein quality control, and neurotransmission such as cyclin D1, HSP70, and ACHE genes was differentially expressed in the presence of these chemicals, most noticeably in treatment of VB. Benzoates 251-253 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 32064399-2 2020 The piperidones were further converted into analogues of donepezil, an acetylcholinesterase inhibiting drug used in the treatment of Alzheimer"s disease. Piperidones 4-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 32064399-2 2020 The piperidones were further converted into analogues of donepezil, an acetylcholinesterase inhibiting drug used in the treatment of Alzheimer"s disease. donepezil 57-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 32064399-4 2020 Biological evaluation of the acetylcholinesterase inhibition by these analogues provides a new insight into structure-activity relationship studies with regard to donepezil"s piperidine moiety toward stereochemical enhancement. donepezil 163-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 31813907-3 2020 Inhibitor A03 displayed the most potent inhibition activity on AChE at enzymatic level with IC50 value of 180 nM, and high selectivity towards AChE over butyrylcholinesterase (BChE) by more than 100-fold. ARC-1039 10-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 31707277-1 2020 A flexible acetylcholinesterase (AChE) film biosensor, based on a AuNPs-MoS2-reduced graphene oxide/polyimide flexible film (rGO/PI) electrode, has been synthesized for paraoxon detection. graphene oxide 85-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 31707277-1 2020 A flexible acetylcholinesterase (AChE) film biosensor, based on a AuNPs-MoS2-reduced graphene oxide/polyimide flexible film (rGO/PI) electrode, has been synthesized for paraoxon detection. graphene oxide 85-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 31707277-1 2020 A flexible acetylcholinesterase (AChE) film biosensor, based on a AuNPs-MoS2-reduced graphene oxide/polyimide flexible film (rGO/PI) electrode, has been synthesized for paraoxon detection. polyimide 100-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 31707277-1 2020 A flexible acetylcholinesterase (AChE) film biosensor, based on a AuNPs-MoS2-reduced graphene oxide/polyimide flexible film (rGO/PI) electrode, has been synthesized for paraoxon detection. polyimide 100-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 31813907-3 2020 Inhibitor A03 displayed the most potent inhibition activity on AChE at enzymatic level with IC50 value of 180 nM, and high selectivity towards AChE over butyrylcholinesterase (BChE) by more than 100-fold. ARC-1039 10-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 31813907-6 2020 Our findings highlighted the therapeutic promise of AChE inhibitors A01-A04 for AD treatment. a01-a04 68-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 30052145-0 2020 A Nafion/AChE-cSWCNT/MWCNT/Au-based amperometric biosensor for the determination of organophosphorous compounds. organophosphorous compounds 84-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 30052145-5 2020 This sensor worked on the AChE inhibition mechanism where the signal is inversely proportional to the amount of organophosphorous compounds. organophosphorous 112-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 30836858-1 2020 In the present study, 23 novel carvacrol derivatives involving the amide moiety as a linker between the alkyl chains and/or the heterocycle nucleus were synthesized and tested in vitro as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. carvacrol 31-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-208 30836858-1 2020 In the present study, 23 novel carvacrol derivatives involving the amide moiety as a linker between the alkyl chains and/or the heterocycle nucleus were synthesized and tested in vitro as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. carvacrol 31-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-214 30836858-1 2020 In the present study, 23 novel carvacrol derivatives involving the amide moiety as a linker between the alkyl chains and/or the heterocycle nucleus were synthesized and tested in vitro as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. Amides 67-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-208 30836858-2 2020 2-(5-Isopropyl-2-methylphenoxy)-N-(quinolin-8-yl)acetamide (5v) revealed the highest inhibition properties against AChE and BuChE with the IC50 values of 1.93 and 0.05 microM, respectively. 2-(5-isopropyl-2-methylphenoxy)-n-(quinolin-8-yl)acetamide 0-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 30836858-2 2020 2-(5-Isopropyl-2-methylphenoxy)-N-(quinolin-8-yl)acetamide (5v) revealed the highest inhibition properties against AChE and BuChE with the IC50 values of 1.93 and 0.05 microM, respectively. 5v 60-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 31660824-3 2020 Docking studies were performed for the compounds F18 and F111 also interaction modes using AChE and BChE enzymes active sites were determined. R 111 57-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 30706763-0 2020 Structural basis of fullerene derivatives as novel potent inhibitors of protein acetylcholinesterase without catalytic active site interaction: insight into the inhibitory mechanism through molecular modeling studies. Fullerenes 20-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 30706763-2 2020 Recent research has demonstrated that some fullerene derivatives serve as a new nanoscale class of potent inhibitors of AChE, but the specific inhibition mechanism remains unclear. Fullerenes 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 30706763-3 2020 In the present article, several molecular modeling methods, such as molecular docking, molecular dynamics simulations and molecular mechanics/generalized Born surface area calculations, were used for the investigation of the binding mode and inhibition mechanism of fullerene inhibitions for AChE. Fullerenes 266-275 acetylcholinesterase (Cartwright blood group) Homo sapiens 292-296 30706763-6 2020 The interactions of a fullerene backbone with AChE are at the same level in different single side chain systems and seem to be related to the length or aromaticity of the side chain. Fullerenes 22-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 30706763-7 2020 The inhibitor with multihydroxyl side chains shows an obviously large electrostatic interaction as it forms additional hydrogen bonds with AChE. Hydrogen 119-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 31816742-0 2020 Copper(II) complex as a turn on fluorescent sensing platform for acetylcholinesterase activity with high sensitivity. cupric ion 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 31816742-2 2020 A "turn on" fluorometric assay is described herein for AChE activity detection, according to the specific enzyme catalyzed reaction of acetylcholine (ATCh) by AChE, which generates thiocholine (TCh) as the product. Acetylcholine 135-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 31816742-2 2020 A "turn on" fluorometric assay is described herein for AChE activity detection, according to the specific enzyme catalyzed reaction of acetylcholine (ATCh) by AChE, which generates thiocholine (TCh) as the product. Acetylcholine 135-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 31816742-2 2020 A "turn on" fluorometric assay is described herein for AChE activity detection, according to the specific enzyme catalyzed reaction of acetylcholine (ATCh) by AChE, which generates thiocholine (TCh) as the product. Thiocholine 181-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 31816742-2 2020 A "turn on" fluorometric assay is described herein for AChE activity detection, according to the specific enzyme catalyzed reaction of acetylcholine (ATCh) by AChE, which generates thiocholine (TCh) as the product. Thiocholine 181-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 31816742-2 2020 A "turn on" fluorometric assay is described herein for AChE activity detection, according to the specific enzyme catalyzed reaction of acetylcholine (ATCh) by AChE, which generates thiocholine (TCh) as the product. Thiocholine 151-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 31816742-2 2020 A "turn on" fluorometric assay is described herein for AChE activity detection, according to the specific enzyme catalyzed reaction of acetylcholine (ATCh) by AChE, which generates thiocholine (TCh) as the product. Thiocholine 151-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 31816742-4 2020 The fluorescence-silent HBTP-Cu2+ complex could be broken by TCh generated from reaction of ATCh with AChE, giving rise to HBTP release which originates from competitive coordination of TCh with Cu2+. hbtp 24-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 31816742-4 2020 The fluorescence-silent HBTP-Cu2+ complex could be broken by TCh generated from reaction of ATCh with AChE, giving rise to HBTP release which originates from competitive coordination of TCh with Cu2+. cupric ion 29-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 31816742-4 2020 The fluorescence-silent HBTP-Cu2+ complex could be broken by TCh generated from reaction of ATCh with AChE, giving rise to HBTP release which originates from competitive coordination of TCh with Cu2+. Thiocholine 61-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 31816742-4 2020 The fluorescence-silent HBTP-Cu2+ complex could be broken by TCh generated from reaction of ATCh with AChE, giving rise to HBTP release which originates from competitive coordination of TCh with Cu2+. hbtp 123-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 31816742-4 2020 The fluorescence-silent HBTP-Cu2+ complex could be broken by TCh generated from reaction of ATCh with AChE, giving rise to HBTP release which originates from competitive coordination of TCh with Cu2+. Thiocholine 93-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 31816742-4 2020 The fluorescence-silent HBTP-Cu2+ complex could be broken by TCh generated from reaction of ATCh with AChE, giving rise to HBTP release which originates from competitive coordination of TCh with Cu2+. cupric ion 195-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 31816742-6 2020 Furthermore, both HBTP-Cu2+ and HBTP show little toxicity to live cells and is available in visualizing cellular AChE activity. hbtp 18-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 31816742-6 2020 Furthermore, both HBTP-Cu2+ and HBTP show little toxicity to live cells and is available in visualizing cellular AChE activity. cupric ion 23-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 31816742-6 2020 Furthermore, both HBTP-Cu2+ and HBTP show little toxicity to live cells and is available in visualizing cellular AChE activity. hbtp 32-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 31857189-1 2020 V-type agents are highly toxic organophosphorus nerve agents that inhibit acetylcholinesterase in the nervous system, causing a series of poison symptoms. Organophosphates 31-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 32013037-1 2020 An unsubstituted 2-hydroxyphenylbenzimidazole has recently been included as a scaffold in a series of hybrids (including the hit compound PZ1) based on the framework of the acetylcholinesterase (AChE) inhibitor Donepezil, which is a new promising multi-target ligand in Alzheimer"s disease (AD) treatment. Aligeron 17-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-193 32013037-1 2020 An unsubstituted 2-hydroxyphenylbenzimidazole has recently been included as a scaffold in a series of hybrids (including the hit compound PZ1) based on the framework of the acetylcholinesterase (AChE) inhibitor Donepezil, which is a new promising multi-target ligand in Alzheimer"s disease (AD) treatment. Aligeron 17-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 32013037-1 2020 An unsubstituted 2-hydroxyphenylbenzimidazole has recently been included as a scaffold in a series of hybrids (including the hit compound PZ1) based on the framework of the acetylcholinesterase (AChE) inhibitor Donepezil, which is a new promising multi-target ligand in Alzheimer"s disease (AD) treatment. donepezil 211-220 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-193 32013037-1 2020 An unsubstituted 2-hydroxyphenylbenzimidazole has recently been included as a scaffold in a series of hybrids (including the hit compound PZ1) based on the framework of the acetylcholinesterase (AChE) inhibitor Donepezil, which is a new promising multi-target ligand in Alzheimer"s disease (AD) treatment. donepezil 211-220 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 31942651-8 2020 The formulation demonstrated sustained release of rivastigmine tartrate for 7 days in vivo with promising biocompatibility and acetylcholinesterase inhibition efficacy for 14 days. Rivastigmine 50-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 31357051-0 2020 Colorimetric assay of acetylcholinesterase inhibitor tacrine based on MoO2 nanoparticles as peroxidase mimetics. Tacrine 53-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 31357051-0 2020 Colorimetric assay of acetylcholinesterase inhibitor tacrine based on MoO2 nanoparticles as peroxidase mimetics. molybdenum dioxide 70-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 31357051-6 2020 Acetylcholinesterase (AChE) could catalyze the hydrolysis of acetylthiocholine chloride (ATCh) into thiocholine (TCh), which could reduce oxTMB to decrease the absorbance in solution. Acetylthiocholine chloride 61-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 31357051-6 2020 Acetylcholinesterase (AChE) could catalyze the hydrolysis of acetylthiocholine chloride (ATCh) into thiocholine (TCh), which could reduce oxTMB to decrease the absorbance in solution. Acetylthiocholine chloride 61-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 31357051-6 2020 Acetylcholinesterase (AChE) could catalyze the hydrolysis of acetylthiocholine chloride (ATCh) into thiocholine (TCh), which could reduce oxTMB to decrease the absorbance in solution. atch 89-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 31357051-6 2020 Acetylcholinesterase (AChE) could catalyze the hydrolysis of acetylthiocholine chloride (ATCh) into thiocholine (TCh), which could reduce oxTMB to decrease the absorbance in solution. atch 89-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 31357051-6 2020 Acetylcholinesterase (AChE) could catalyze the hydrolysis of acetylthiocholine chloride (ATCh) into thiocholine (TCh), which could reduce oxTMB to decrease the absorbance in solution. Thiocholine 67-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 31357051-6 2020 Acetylcholinesterase (AChE) could catalyze the hydrolysis of acetylthiocholine chloride (ATCh) into thiocholine (TCh), which could reduce oxTMB to decrease the absorbance in solution. Thiocholine 67-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 31357051-6 2020 Acetylcholinesterase (AChE) could catalyze the hydrolysis of acetylthiocholine chloride (ATCh) into thiocholine (TCh), which could reduce oxTMB to decrease the absorbance in solution. Thiocholine 90-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 31357051-6 2020 Acetylcholinesterase (AChE) could catalyze the hydrolysis of acetylthiocholine chloride (ATCh) into thiocholine (TCh), which could reduce oxTMB to decrease the absorbance in solution. Thiocholine 90-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 31357051-6 2020 Acetylcholinesterase (AChE) could catalyze the hydrolysis of acetylthiocholine chloride (ATCh) into thiocholine (TCh), which could reduce oxTMB to decrease the absorbance in solution. oxtmb 138-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 31357051-6 2020 Acetylcholinesterase (AChE) could catalyze the hydrolysis of acetylthiocholine chloride (ATCh) into thiocholine (TCh), which could reduce oxTMB to decrease the absorbance in solution. oxtmb 138-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 31357051-7 2020 In the presence of AChE inhibitor tacrine, the generation of TCh was inhibited and the absorbance was preserved. Tacrine 34-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 31357051-7 2020 In the presence of AChE inhibitor tacrine, the generation of TCh was inhibited and the absorbance was preserved. Thiocholine 61-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 31357051-8 2020 Based on these properties, a colorimetric assay method was developed for AChE inhibitor tacrine. Tacrine 88-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 31735356-3 2020 They were also effective at displacing propidium from the peripheral anionic site (PAS) of acetylcholinesterase (AChE), suggesting that they could block AChE-induced beta-amyloid aggregation. Propidium 39-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 31735356-3 2020 They were also effective at displacing propidium from the peripheral anionic site (PAS) of acetylcholinesterase (AChE), suggesting that they could block AChE-induced beta-amyloid aggregation. Propidium 39-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 31735356-3 2020 They were also effective at displacing propidium from the peripheral anionic site (PAS) of acetylcholinesterase (AChE), suggesting that they could block AChE-induced beta-amyloid aggregation. Propidium 39-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 31838287-0 2020 New phosphazine and phosphazide derivatives as multifunctional ligands targeting acetylcholinesterase and beta-Amyloid aggregation for treatment of Alzheimer"s disease. phosphazine 4-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 31838287-0 2020 New phosphazine and phosphazide derivatives as multifunctional ligands targeting acetylcholinesterase and beta-Amyloid aggregation for treatment of Alzheimer"s disease. 3'-azido-2',3'-dideoxythymidine 5'-H-phoshonate 20-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 31838287-1 2020 Phosphazine and phosphazide derivatives are described herein as a new class of selective and potent acetylcholinesterase (AChE) inhibitors and beta-amyloid aggregation inhibitors. phosphazine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 31838287-1 2020 Phosphazine and phosphazide derivatives are described herein as a new class of selective and potent acetylcholinesterase (AChE) inhibitors and beta-amyloid aggregation inhibitors. phosphazine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 31838287-1 2020 Phosphazine and phosphazide derivatives are described herein as a new class of selective and potent acetylcholinesterase (AChE) inhibitors and beta-amyloid aggregation inhibitors. 3'-azido-2',3'-dideoxythymidine 5'-H-phoshonate 16-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 31838287-1 2020 Phosphazine and phosphazide derivatives are described herein as a new class of selective and potent acetylcholinesterase (AChE) inhibitors and beta-amyloid aggregation inhibitors. 3'-azido-2',3'-dideoxythymidine 5'-H-phoshonate 16-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 31838287-6 2020 Especially, the coumarin phosphazide derivative (8b) presented the best AChE inhibition selectivity index (IC50 = 34.96 nM, AChE/BuChE; 3.81) together with good inhibition ability against MMP-2 (IC50 = 441.33 nM) and self-induced Abeta1-42 aggregation (IC50 = 337.77 nM). coumarin 16-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 31838287-6 2020 Especially, the coumarin phosphazide derivative (8b) presented the best AChE inhibition selectivity index (IC50 = 34.96 nM, AChE/BuChE; 3.81) together with good inhibition ability against MMP-2 (IC50 = 441.33 nM) and self-induced Abeta1-42 aggregation (IC50 = 337.77 nM). coumarin 16-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 31838287-6 2020 Especially, the coumarin phosphazide derivative (8b) presented the best AChE inhibition selectivity index (IC50 = 34.96 nM, AChE/BuChE; 3.81) together with good inhibition ability against MMP-2 (IC50 = 441.33 nM) and self-induced Abeta1-42 aggregation (IC50 = 337.77 nM). 3'-azido-2',3'-dideoxythymidine 5'-H-phoshonate 25-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 31838287-6 2020 Especially, the coumarin phosphazide derivative (8b) presented the best AChE inhibition selectivity index (IC50 = 34.96 nM, AChE/BuChE; 3.81) together with good inhibition ability against MMP-2 (IC50 = 441.33 nM) and self-induced Abeta1-42 aggregation (IC50 = 337.77 nM). 3'-azido-2',3'-dideoxythymidine 5'-H-phoshonate 25-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 32698655-3 2020 Then, acetylcholinesterase enzyme (AChE) was covalently immobilized on these polymers to improve properties (including activity, reusability, and storage stability). Polymers 77-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-33 32698655-3 2020 Then, acetylcholinesterase enzyme (AChE) was covalently immobilized on these polymers to improve properties (including activity, reusability, and storage stability). Polymers 77-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 32698655-4 2020 Accordingly, organophosphate (malathion, acephate, chlorpyrifos methyl) and carbamate (carbofuran, methiocarb, methomyl), which are used to prevent harmful organisms in some agricultural products were enzymatically determined based on their inhibitory activity on AChE. Organophosphates 13-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 264-268 32698655-4 2020 Accordingly, organophosphate (malathion, acephate, chlorpyrifos methyl) and carbamate (carbofuran, methiocarb, methomyl), which are used to prevent harmful organisms in some agricultural products were enzymatically determined based on their inhibitory activity on AChE. Malathion 30-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 264-268 32698655-4 2020 Accordingly, organophosphate (malathion, acephate, chlorpyrifos methyl) and carbamate (carbofuran, methiocarb, methomyl), which are used to prevent harmful organisms in some agricultural products were enzymatically determined based on their inhibitory activity on AChE. Carbamates 76-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 264-268 32698655-4 2020 Accordingly, organophosphate (malathion, acephate, chlorpyrifos methyl) and carbamate (carbofuran, methiocarb, methomyl), which are used to prevent harmful organisms in some agricultural products were enzymatically determined based on their inhibitory activity on AChE. Carbofuran 87-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 264-268 32698655-4 2020 Accordingly, organophosphate (malathion, acephate, chlorpyrifos methyl) and carbamate (carbofuran, methiocarb, methomyl), which are used to prevent harmful organisms in some agricultural products were enzymatically determined based on their inhibitory activity on AChE. Methiocarb 99-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 264-268 32698655-4 2020 Accordingly, organophosphate (malathion, acephate, chlorpyrifos methyl) and carbamate (carbofuran, methiocarb, methomyl), which are used to prevent harmful organisms in some agricultural products were enzymatically determined based on their inhibitory activity on AChE. Methomyl 111-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 264-268 31309898-8 2020 RESULTS: The results of the docking studies showed that the newly designed phosphorus and thiophosphorus tacrine analogs, theoretically possess AChE and BChE-binding ability. Phosphorus 75-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 31309898-8 2020 RESULTS: The results of the docking studies showed that the newly designed phosphorus and thiophosphorus tacrine analogs, theoretically possess AChE and BChE-binding ability. thiophosphorus tacrine 90-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 31660824-1 2020 BACKGROUND: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are known serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ACh), which is a significant neurotransmitter for regulation of cognition in animals. cholecystokinin C-terminal flanking peptide 83-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 31660824-1 2020 BACKGROUND: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are known serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ACh), which is a significant neurotransmitter for regulation of cognition in animals. cholecystokinin C-terminal flanking peptide 83-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 31660824-1 2020 BACKGROUND: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are known serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ACh), which is a significant neurotransmitter for regulation of cognition in animals. Acetylcholine 142-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 31660824-1 2020 BACKGROUND: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are known serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ACh), which is a significant neurotransmitter for regulation of cognition in animals. Acetylcholine 142-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 31660824-1 2020 BACKGROUND: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are known serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ACh), which is a significant neurotransmitter for regulation of cognition in animals. Acetylcholine 34-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 31884928-1 2020 Acetylcholinesterase inhibitors are the most promising therapeutics for Alzheimer"s disease treatment as these prevent the loss of acetylcholine and slows the progression of disease. Acetylcholine 131-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 31902355-4 2020 To this end, acetylcholinesterase inhibitors (AChEIs) are commonly used. Acetylcholine 46-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-33 31902355-9 2020 Namely, AChE has an important role in acetylcholine-mediated neurotransmission. Acetylcholine 38-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-12 31902355-11 2020 AChE hydrolyses of ACh to acetate and choline as an important neurotransmitter substance. Acetates 26-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 31902355-11 2020 AChE hydrolyses of ACh to acetate and choline as an important neurotransmitter substance. Choline 38-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 31022458-1 2020 There is a unique in vivo interplay involving the mechanism of inactivation of acetylcholinesterase (AChE) by toxic organophosphorus (OP) compounds and the restoration of AChE activity by oxime antidotes. organophosphorus 116-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 31022458-1 2020 There is a unique in vivo interplay involving the mechanism of inactivation of acetylcholinesterase (AChE) by toxic organophosphorus (OP) compounds and the restoration of AChE activity by oxime antidotes. organophosphorus 116-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 31022458-1 2020 There is a unique in vivo interplay involving the mechanism of inactivation of acetylcholinesterase (AChE) by toxic organophosphorus (OP) compounds and the restoration of AChE activity by oxime antidotes. Oximes 188-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 31022458-2 2020 OP compounds form covalent adducts to this critical enzyme target and oximes are introduced to directly displace the OP from AChE. Oximes 70-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 31854974-7 2020 A sensitive bioassay for acetylcholinesterase (AChE) was established based on the excellent oxidase-like activity of C-CoCu-HNC, offering a linear detection range from 0.0001 to 1 mU/mL with an ultralow detection limit of 0.1 mU/L. 1-hydroxy-11-norcadinan-5-en-4-one 117-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 31854974-7 2020 A sensitive bioassay for acetylcholinesterase (AChE) was established based on the excellent oxidase-like activity of C-CoCu-HNC, offering a linear detection range from 0.0001 to 1 mU/mL with an ultralow detection limit of 0.1 mU/L. 1-hydroxy-11-norcadinan-5-en-4-one 117-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 31715352-8 2020 Acetylcholinesterase (AChE) competitive ELISA kit demonstrated that the resulting PEGylated STZ competes against biological TST, especially at lower concentrations. Stanozolol 92-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 31715352-8 2020 Acetylcholinesterase (AChE) competitive ELISA kit demonstrated that the resulting PEGylated STZ competes against biological TST, especially at lower concentrations. Stanozolol 92-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 31770565-1 2020 The main function of AChE is the hydrolysis of the neurotransmitter acetylcholine (ACh) at the neuromuscular and in cholinergic brain synapses. Acetylcholine 68-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 31791684-0 2020 Novel 2-methylimidazolium salts: Synthesis, characterization, molecular docking, and carbonic anhydrase and acetylcholinesterase inhibitory properties. 2-methylimidazolium salts 6-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 31818478-4 2020 In particular, compound 6c bearing a pyrrolidine group showed the highest activities against self- and Cu2+-induced Abeta1-42 aggregation (70.65% and 54.89% at 25.0 microM, respectively), highly selective inhibition towards AChE and MAO-B (IC50 = 7.15 muM and 0.43 muM respectively), good antioxidant ability and metal-chelating property. Copper 103-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 224-228 31887472-1 2020 Thirty ferulic acid-based 1,3,4-oxadiazole molecular hybrids were designed, synthesized, and screened them for multifunctional inhibitory potential against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and beta-secretase-1 (BACE-1). ferulic acid 7-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-176 31887472-1 2020 Thirty ferulic acid-based 1,3,4-oxadiazole molecular hybrids were designed, synthesized, and screened them for multifunctional inhibitory potential against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and beta-secretase-1 (BACE-1). ferulic acid 7-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-182 31887472-1 2020 Thirty ferulic acid-based 1,3,4-oxadiazole molecular hybrids were designed, synthesized, and screened them for multifunctional inhibitory potential against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and beta-secretase-1 (BACE-1). 1,3,4-oxadiazole 26-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-176 31887472-1 2020 Thirty ferulic acid-based 1,3,4-oxadiazole molecular hybrids were designed, synthesized, and screened them for multifunctional inhibitory potential against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and beta-secretase-1 (BACE-1). 1,3,4-oxadiazole 26-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-182 31887472-5 2020 Compounds 6j and 6k elicited significant displacement of propidium iodide from PAS-AChE, excellent BBB permeability in PAMPA assay, and anti-Abeta aggregatory activity in self- and AChE-induced experiments with neuroprotective activity towards neuroblastoma SH-SY5Y cells. Propidium 57-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 32766549-2 2020 Acetylcholinesterase inhibitors are one of the few treatment options for Alzheimer"s disease, where levels of available acetylcholine are enhanced to counteract the cholinergic loss. Acetylcholine 120-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32329687-6 2020 METHODS: In this study, 41 abietane diterpenoids have been assayed for antioxidant and anticholinesterase (both for AChE and BuChE) properties in vitro, which were previously isolated from Salvia species, and structurally determined by spectroscopic methods, particularly intensive 1D- and 2DNMR and mass experiments. Abietanes 27-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 32329687-8 2020 RESULTS: Thirteen out of the tested 41 abietane diterpenoids exhibited at least 50% inhibition on either AChE or BuChE. Abietanes 39-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 32329687-9 2020 The strongest inhibitory activity was obtained for Bractealine against BuChE (3.43 microM) and AChE (33.21 microM) while the most selective ligand was found to be Hypargenin E against BuChE enzyme (6.93 microM). Bractealine 51-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 32329687-11 2020 The results obtained from molecular modelling studies of Hypargenin E and Bractealine on AChE and BuChE were found to be in accordance with the in vitro anti-cholinesterase activity tests. HYPARGENIN E 57-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 32329687-11 2020 The results obtained from molecular modelling studies of Hypargenin E and Bractealine on AChE and BuChE were found to be in accordance with the in vitro anti-cholinesterase activity tests. Bractealine 74-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 31894743-5 2020 However, after analyzing the binding energy (DeltaG), the documented data shows that bacoside X, bacoside A, 3-beta-D-glucosylstigmasterol and daucosterol could be good inhibitors in the inhibition of AChE and BuChE activities. bacoside x 85-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 201-205 31894743-5 2020 However, after analyzing the binding energy (DeltaG), the documented data shows that bacoside X, bacoside A, 3-beta-D-glucosylstigmasterol and daucosterol could be good inhibitors in the inhibition of AChE and BuChE activities. bacoside A 97-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 201-205 31894743-5 2020 However, after analyzing the binding energy (DeltaG), the documented data shows that bacoside X, bacoside A, 3-beta-D-glucosylstigmasterol and daucosterol could be good inhibitors in the inhibition of AChE and BuChE activities. 3-beta-d-glucosylstigmasterol 109-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 201-205 31894743-5 2020 However, after analyzing the binding energy (DeltaG), the documented data shows that bacoside X, bacoside A, 3-beta-D-glucosylstigmasterol and daucosterol could be good inhibitors in the inhibition of AChE and BuChE activities. lyoniside 143-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 201-205 32264807-0 2020 Ajmalicine and its Analogues against AChE and BuChE for the Management of Alzheimer"s Disease: An In-silico study. raubasine 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 32264807-8 2020 The docking results revealed Ajmalicine, a prominent natural alkaloid, showing promising inhibitory potential against AChE and BuChE with the binding energy of - 9.02 and -8.89 kcal/mole respectively. raubasine 29-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 31675511-0 2020 6-Methyluracil derivatives as peripheral site ligand-hydroxamic acid conjugates: Reactivation for paraoxon-inhibited acetylcholinesterase. 6-methyluracil 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 31675511-0 2020 6-Methyluracil derivatives as peripheral site ligand-hydroxamic acid conjugates: Reactivation for paraoxon-inhibited acetylcholinesterase. Hydroxamic Acids 53-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 31675511-2 2020 Using paraoxon (POX) as a model organophosphate, it was shown that 6-methyluracil derivatives linked with hydroxamic acid are able to reactivate POX-inhibited human acetylcholinesterase (AChE) in vitro. Paraoxon 6-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-185 31675511-2 2020 Using paraoxon (POX) as a model organophosphate, it was shown that 6-methyluracil derivatives linked with hydroxamic acid are able to reactivate POX-inhibited human acetylcholinesterase (AChE) in vitro. Paraoxon 6-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 31675511-2 2020 Using paraoxon (POX) as a model organophosphate, it was shown that 6-methyluracil derivatives linked with hydroxamic acid are able to reactivate POX-inhibited human acetylcholinesterase (AChE) in vitro. Paraoxon 16-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-185 31675511-2 2020 Using paraoxon (POX) as a model organophosphate, it was shown that 6-methyluracil derivatives linked with hydroxamic acid are able to reactivate POX-inhibited human acetylcholinesterase (AChE) in vitro. Paraoxon 16-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 31675511-2 2020 Using paraoxon (POX) as a model organophosphate, it was shown that 6-methyluracil derivatives linked with hydroxamic acid are able to reactivate POX-inhibited human acetylcholinesterase (AChE) in vitro. Organophosphates 32-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-185 31675511-2 2020 Using paraoxon (POX) as a model organophosphate, it was shown that 6-methyluracil derivatives linked with hydroxamic acid are able to reactivate POX-inhibited human acetylcholinesterase (AChE) in vitro. Organophosphates 32-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 31675511-2 2020 Using paraoxon (POX) as a model organophosphate, it was shown that 6-methyluracil derivatives linked with hydroxamic acid are able to reactivate POX-inhibited human acetylcholinesterase (AChE) in vitro. 6-methyluracil 67-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-185 31675511-2 2020 Using paraoxon (POX) as a model organophosphate, it was shown that 6-methyluracil derivatives linked with hydroxamic acid are able to reactivate POX-inhibited human acetylcholinesterase (AChE) in vitro. 6-methyluracil 67-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 31675511-2 2020 Using paraoxon (POX) as a model organophosphate, it was shown that 6-methyluracil derivatives linked with hydroxamic acid are able to reactivate POX-inhibited human acetylcholinesterase (AChE) in vitro. Hydroxamic Acids 106-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-185 31675511-2 2020 Using paraoxon (POX) as a model organophosphate, it was shown that 6-methyluracil derivatives linked with hydroxamic acid are able to reactivate POX-inhibited human acetylcholinesterase (AChE) in vitro. Hydroxamic Acids 106-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 32986667-3 2020 OBJECTIVE: The aim of the current study was to evaluate the potential of two tacrine-donepezil hybrid molecules (TA8Amino and TAHB3), which are AChE inhibitors, to induce neurodifferentiation and neuritogenesis in SH-SY5Y cells. Tacrine 77-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 32986667-3 2020 OBJECTIVE: The aim of the current study was to evaluate the potential of two tacrine-donepezil hybrid molecules (TA8Amino and TAHB3), which are AChE inhibitors, to induce neurodifferentiation and neuritogenesis in SH-SY5Y cells. Donepezil 85-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 32986667-3 2020 OBJECTIVE: The aim of the current study was to evaluate the potential of two tacrine-donepezil hybrid molecules (TA8Amino and TAHB3), which are AChE inhibitors, to induce neurodifferentiation and neuritogenesis in SH-SY5Y cells. ta8amino 113-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 32986667-3 2020 OBJECTIVE: The aim of the current study was to evaluate the potential of two tacrine-donepezil hybrid molecules (TA8Amino and TAHB3), which are AChE inhibitors, to induce neurodifferentiation and neuritogenesis in SH-SY5Y cells. tahb3 126-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 33442173-11 2020 Conclusion: Organophosphate pesticide exposure lowered erythrocyte AChE activity and increased oxidative stress. Organophosphates 12-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 31686175-6 2020 A low dose of galantamine was chosen to minimize acetylcholinesterase inhibition, which was verified in blood assays. Galantamine 14-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 31614352-4 2020 In animals and humans, distigmine was reported to inhibit acetylcholinesterase (AChE) and improve myasthenia gravis for an extended period. distigmine 23-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 31614352-4 2020 In animals and humans, distigmine was reported to inhibit acetylcholinesterase (AChE) and improve myasthenia gravis for an extended period. distigmine 23-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 31686175-10 2020 A trend toward RT reduction by galantamine correlated with acetylcholinesterase inhibition. Galantamine 31-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 31893002-10 2020 CONCLUSION: Atropine combined with penehyclidine benefits OP patients by enhancing the cure rate, mortality rate, time to atropinization, AchE recovery, IMS rate, total ADR and duration of hospitalization. Atropine 12-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 31893002-10 2020 CONCLUSION: Atropine combined with penehyclidine benefits OP patients by enhancing the cure rate, mortality rate, time to atropinization, AchE recovery, IMS rate, total ADR and duration of hospitalization. penehyclidine 35-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 31847089-1 2019 Alkaloids having acetylcholinesterase (AChE) inhibitory activity are commonly found in traditional Chinese medicine (TCM); for example, berberine from Coptis chinensis, galantamine from Lycoris radiata, and huperzine A from Huperzia serrata. Berberine 136-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 31882733-3 2019 In this study, a set of compounds bearing phenoxyethyl amines were synthesized and their inhibitory activity toward electric eel AChE (eeAChE) and equine butyrylcholinesterase (eqBuChE) were evaluated. 2-phenoxyethyl propionate 42-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 31882733-8 2019 Also during MD simulation it was discovered for the first time that binding of substrates like donepezil to dual CAS and PAS or solely CAS region might have a suppressive impact on 4-alpha-helical bundles near the tryptophan amphiphilic tetramerization (WAT) domain of AChE and residues which are far away from AChE active site. donepezil 95-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 269-273 31882733-8 2019 Also during MD simulation it was discovered for the first time that binding of substrates like donepezil to dual CAS and PAS or solely CAS region might have a suppressive impact on 4-alpha-helical bundles near the tryptophan amphiphilic tetramerization (WAT) domain of AChE and residues which are far away from AChE active site. donepezil 95-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 311-315 31882733-8 2019 Also during MD simulation it was discovered for the first time that binding of substrates like donepezil to dual CAS and PAS or solely CAS region might have a suppressive impact on 4-alpha-helical bundles near the tryptophan amphiphilic tetramerization (WAT) domain of AChE and residues which are far away from AChE active site. Tryptophan 214-224 acetylcholinesterase (Cartwright blood group) Homo sapiens 269-273 31882733-8 2019 Also during MD simulation it was discovered for the first time that binding of substrates like donepezil to dual CAS and PAS or solely CAS region might have a suppressive impact on 4-alpha-helical bundles near the tryptophan amphiphilic tetramerization (WAT) domain of AChE and residues which are far away from AChE active site. Tryptophan 214-224 acetylcholinesterase (Cartwright blood group) Homo sapiens 311-315 31874099-3 2019 Background This study evaluates the antioxidant activity and enzyme inhibitory properties of the n-butanol fraction of Senna podocarpa leaves on alpha-amylase, alpha-glucosidase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, arginase, phosphodiesterase 5 (PDE-5), and angiotensin converting enzyme (ACE). 1-Butanol 97-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 179-199 31874099-3 2019 Background This study evaluates the antioxidant activity and enzyme inhibitory properties of the n-butanol fraction of Senna podocarpa leaves on alpha-amylase, alpha-glucosidase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, arginase, phosphodiesterase 5 (PDE-5), and angiotensin converting enzyme (ACE). 1-Butanol 97-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 201-205 31874099-7 2019 The n-butanol fraction of S. podocarpa leaves also inhibited alpha-glucosidase, alpha-amylase, AChE, BChE, tyrosinase, arginase, PDE-5, and ACE at the concentration tested. 1-Butanol 4-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 31878304-2 2019 Herein, we focus on generating 12 chalcone-donepezil hybrids, with the goal of simultaneously targeting amyloid-beta (Abeta) peptides as well as cholinesterases (i.e., acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)). Chalcone 34-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-188 31878304-2 2019 Herein, we focus on generating 12 chalcone-donepezil hybrids, with the goal of simultaneously targeting amyloid-beta (Abeta) peptides as well as cholinesterases (i.e., acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)). Donepezil 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-188 31847089-1 2019 Alkaloids having acetylcholinesterase (AChE) inhibitory activity are commonly found in traditional Chinese medicine (TCM); for example, berberine from Coptis chinensis, galantamine from Lycoris radiata, and huperzine A from Huperzia serrata. Berberine 136-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 31847089-1 2019 Alkaloids having acetylcholinesterase (AChE) inhibitory activity are commonly found in traditional Chinese medicine (TCM); for example, berberine from Coptis chinensis, galantamine from Lycoris radiata, and huperzine A from Huperzia serrata. Galantamine 169-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 31847089-1 2019 Alkaloids having acetylcholinesterase (AChE) inhibitory activity are commonly found in traditional Chinese medicine (TCM); for example, berberine from Coptis chinensis, galantamine from Lycoris radiata, and huperzine A from Huperzia serrata. Galantamine 169-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 31847089-1 2019 Alkaloids having acetylcholinesterase (AChE) inhibitory activity are commonly found in traditional Chinese medicine (TCM); for example, berberine from Coptis chinensis, galantamine from Lycoris radiata, and huperzine A from Huperzia serrata. huperzine A 207-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 31847089-1 2019 Alkaloids having acetylcholinesterase (AChE) inhibitory activity are commonly found in traditional Chinese medicine (TCM); for example, berberine from Coptis chinensis, galantamine from Lycoris radiata, and huperzine A from Huperzia serrata. huperzine A 207-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 31847089-3 2019 Fangchinoline from STR and coptisine and/or berberine from CR and/or PCC are active alkaloids in inhibiting AChE. fangchinoline 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 31847089-3 2019 Fangchinoline from STR and coptisine and/or berberine from CR and/or PCC are active alkaloids in inhibiting AChE. coptisine 27-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 31847089-3 2019 Fangchinoline from STR and coptisine and/or berberine from CR and/or PCC are active alkaloids in inhibiting AChE. Berberine 44-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 31847089-4 2019 The traditional usage of paired herbs suggests the synergistic effect of fangchinoline-coptisine or fangchinoline-berberine pairing in AChE inhibition. fangchinoline 100-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 31847089-8 2019 It was found that fangchinoline showed AChE inhibitory potency; furthermore, fangchinoline-coptisine/berberine pairs (at ratios of 1:5, 1:2, 1:1, and 2:1) synergistically inhibited AChE; the combination index (CI) at different ratios was less than one when Fa = 0.5, suggesting synergistic inhibition of AChE. fangchinoline 18-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 31847089-8 2019 It was found that fangchinoline showed AChE inhibitory potency; furthermore, fangchinoline-coptisine/berberine pairs (at ratios of 1:5, 1:2, 1:1, and 2:1) synergistically inhibited AChE; the combination index (CI) at different ratios was less than one when Fa = 0.5, suggesting synergistic inhibition of AChE. fangchinoline 77-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 31847089-8 2019 It was found that fangchinoline showed AChE inhibitory potency; furthermore, fangchinoline-coptisine/berberine pairs (at ratios of 1:5, 1:2, 1:1, and 2:1) synergistically inhibited AChE; the combination index (CI) at different ratios was less than one when Fa = 0.5, suggesting synergistic inhibition of AChE. fangchinoline 77-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 31847089-8 2019 It was found that fangchinoline showed AChE inhibitory potency; furthermore, fangchinoline-coptisine/berberine pairs (at ratios of 1:5, 1:2, 1:1, and 2:1) synergistically inhibited AChE; the combination index (CI) at different ratios was less than one when Fa = 0.5, suggesting synergistic inhibition of AChE. Berberine 101-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 31847089-8 2019 It was found that fangchinoline showed AChE inhibitory potency; furthermore, fangchinoline-coptisine/berberine pairs (at ratios of 1:5, 1:2, 1:1, and 2:1) synergistically inhibited AChE; the combination index (CI) at different ratios was less than one when Fa = 0.5, suggesting synergistic inhibition of AChE. Berberine 101-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 31891098-6 2019 A concomitant inhibition of human acetylcholinesterase and human monoamine oxidase B, with IC50 values of 5.58 and 7.20 muM, respectively, was achieved with the dual-target 6-(4-(piperidin-1-yl)butoxy)-4H-chromen-4-one (7). 7-(4-(4-(6-fluorobenzo(d)isoxazol-3-yl)-piperidin-1-yl)butoxy)-4-methyl-8-chloro-2H-chromen-2-one 173-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 31808389-2 2021 OBJECTIVE: Here we synthesize 10 chalcone derivatives to be evaluated their in vitro enzymatic inhibition activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Chalcones 33-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-143 31808389-2 2021 OBJECTIVE: Here we synthesize 10 chalcone derivatives to be evaluated their in vitro enzymatic inhibition activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Chalcones 33-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 31808389-5 2021 Molecular docking studies predicted that this activity might be due to the interaction of the chalcones with important amino acid residues in the binding site of AChE such as SER200 and in that of BChE such as TRP82, SER198, TRP430, TYR440, LEU286 and VAL288. Chalcones 94-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-166 31437810-4 2019 Exclusively, Ce/UiO-66/MWCNTs with a Ce (7%) and MWCNT (30%) matrix was found to not only load more acetylcholinesterase (AChE) onto vacant sites but also increase electron transfer and decrease the number of diffusion pathways between the thiocholine and electrode surface. Thiocholine 240-251 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 31893002-8 2020 Atropine combined with penehyclidine in OP patients also helped reduce the time to atropinization and AchE recovery, the rate of IMS and the rate of ADR. Atropine 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 31893002-8 2020 Atropine combined with penehyclidine in OP patients also helped reduce the time to atropinization and AchE recovery, the rate of IMS and the rate of ADR. penehyclidine 23-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 31893002-9 2020 Compared with a single dose of atropine, a single dose of penehyclidine also significantly elevated the cure rate, reduced times to atropinization, AchE recovery, and rate of IMS. penehyclidine 58-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 31544276-6 2019 Novel sulfamate derivatives showed Ki values in the range of 23.81-42.97 nM against hCA I, 8.95-52.23 nM against hCA II, 8.10-45.51 nM against AChE, 23.16-81.84 nM against BChE, and 14.02-48.68 nM against alpha-Gly. sulfamic acid 6-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 31437810-4 2019 Exclusively, Ce/UiO-66/MWCNTs with a Ce (7%) and MWCNT (30%) matrix was found to not only load more acetylcholinesterase (AChE) onto vacant sites but also increase electron transfer and decrease the number of diffusion pathways between the thiocholine and electrode surface. Thiocholine 240-251 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 31550630-4 2019 In the absence of OPs, acetylcholinesterase (AChE) hydrolyzed acetylcholine chloride (ATCh) into choline (TCh) and acetate. Acetylcholine 62-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 31550630-4 2019 In the absence of OPs, acetylcholinesterase (AChE) hydrolyzed acetylcholine chloride (ATCh) into choline (TCh) and acetate. thiocarbohydrazide 87-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 31550630-4 2019 In the absence of OPs, acetylcholinesterase (AChE) hydrolyzed acetylcholine chloride (ATCh) into choline (TCh) and acetate. Acetates 115-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 31550630-4 2019 In the absence of OPs, acetylcholinesterase (AChE) hydrolyzed acetylcholine chloride (ATCh) into choline (TCh) and acetate. Acetates 115-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 31550630-6 2019 In the presence of OPs, the activity of AChE was inhibited and the decomposition of MnO2 NS was hindered, therefore the fluorescence intensity of SC was weak and the fluorescence intensity of AR had an obvious increase. OPS 19-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 31325829-0 2019 Spectroscopic and molecular modeling investigation on inhibition effect of nitroaromatic compounds on acetylcholinesterase activity. nitroaromatic 75-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 31325829-3 2019 Here we investigated the effects of three model NACs, nitrobenzene (NB), 1,3-dinitrobenzene (DNB), and 1,3,5-trinitrobenzene (TNB), on the activity of acetylcholinesterase (AChE). 3-dinitrobenzene 73-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-171 31325829-3 2019 Here we investigated the effects of three model NACs, nitrobenzene (NB), 1,3-dinitrobenzene (DNB), and 1,3,5-trinitrobenzene (TNB), on the activity of acetylcholinesterase (AChE). sym-trinitrobenzene 103-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-171 31325829-4 2019 The presence of NACs (up to 0.5 mM) effectively suppressed the AChE-catalyzed hydrolysis of acetylthiocholine iodide, with the suppression effect increasing with the nitro-group substitution (TNB > DNB > NB). nacs 16-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 31325829-4 2019 The presence of NACs (up to 0.5 mM) effectively suppressed the AChE-catalyzed hydrolysis of acetylthiocholine iodide, with the suppression effect increasing with the nitro-group substitution (TNB > DNB > NB). acetylthiocholine iodide 92-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 31325829-4 2019 The presence of NACs (up to 0.5 mM) effectively suppressed the AChE-catalyzed hydrolysis of acetylthiocholine iodide, with the suppression effect increasing with the nitro-group substitution (TNB > DNB > NB). nitro 166-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 31325829-4 2019 The presence of NACs (up to 0.5 mM) effectively suppressed the AChE-catalyzed hydrolysis of acetylthiocholine iodide, with the suppression effect increasing with the nitro-group substitution (TNB > DNB > NB). sym-trinitrobenzene 192-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 31325829-4 2019 The presence of NACs (up to 0.5 mM) effectively suppressed the AChE-catalyzed hydrolysis of acetylthiocholine iodide, with the suppression effect increasing with the nitro-group substitution (TNB > DNB > NB). 3-dinitrobenzene 201-204 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 31325829-5 2019 Consistently, the UV absorption of AChE at 206 nm arising from the skeleton structure decreased by the addition NACs, and the decrease exhibited the same compound sequence, reflecting the perturbing interactions with the skeleton enzyme structure. nacs 112-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 31325829-7 2019 The fluorescence quenching analysis of AChE demonstrated that NB and DNB interacted with both tryptophan (Trp) and tyrosine (Tyr) residues, whereas TNB interacted only with Trp. 3-dinitrobenzene 69-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 31325829-7 2019 The fluorescence quenching analysis of AChE demonstrated that NB and DNB interacted with both tryptophan (Trp) and tyrosine (Tyr) residues, whereas TNB interacted only with Trp. Tryptophan 94-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 31325829-7 2019 The fluorescence quenching analysis of AChE demonstrated that NB and DNB interacted with both tryptophan (Trp) and tyrosine (Tyr) residues, whereas TNB interacted only with Trp. Tryptophan 106-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 31325829-7 2019 The fluorescence quenching analysis of AChE demonstrated that NB and DNB interacted with both tryptophan (Trp) and tyrosine (Tyr) residues, whereas TNB interacted only with Trp. Tyrosine 115-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 31325829-7 2019 The fluorescence quenching analysis of AChE demonstrated that NB and DNB interacted with both tryptophan (Trp) and tyrosine (Tyr) residues, whereas TNB interacted only with Trp. Tyrosine 125-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 31325829-7 2019 The fluorescence quenching analysis of AChE demonstrated that NB and DNB interacted with both tryptophan (Trp) and tyrosine (Tyr) residues, whereas TNB interacted only with Trp. sym-trinitrobenzene 148-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 32995249-1 2019 Rivastigmine is a non-competitive reversible inhibitor of acetylcholinesterase which is approved as one of the fi rst-line treatment options for Alzheimer"s disease. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 32995249-13 2019 rivastigmine, an acetylcholinesterase inhibitor, can precipitate an acute cholinergic crisis in cases of intoxication. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 30482059-4 2019 The benzothiazinone 5Bd showed the best AChE inhibition activity IC50 8.48 muM (cortex) and IC50 39.80 muM (hippocampus). benzothiazinone 4-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 30727776-0 2019 Discovery of novel dual-active 3-(4-(dimethylamino)phenyl)-7-aminoalcoxy-coumarin as potent and selective acetylcholinesterase inhibitor and antioxidant. 3-(4-(dimethylamino)phenyl)-7-aminoalcoxy-coumarin 31-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 30727776-3 2019 The 3-(4-(dimethylamino)phenyl)-7-aminoethoxy-coumarin (6a) was considered a hit, showing good AChE inhibition potency (IC50 = 20 nM) and selectivity (IC50 BuChE/AChE = 354), quite similar to the reference drug donepezil (IC50 = 6 nM; IC50 BuChE/AChE = 365), also presenting antioxidant properties, low citotoxicity and good-predicted ADMET properties. 3-(4-(dimethylamino)phenyl)-7-aminoethoxy-coumarin 4-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 30727776-3 2019 The 3-(4-(dimethylamino)phenyl)-7-aminoethoxy-coumarin (6a) was considered a hit, showing good AChE inhibition potency (IC50 = 20 nM) and selectivity (IC50 BuChE/AChE = 354), quite similar to the reference drug donepezil (IC50 = 6 nM; IC50 BuChE/AChE = 365), also presenting antioxidant properties, low citotoxicity and good-predicted ADMET properties. 3-(4-(dimethylamino)phenyl)-7-aminoethoxy-coumarin 4-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-166 31585263-3 2019 Some new inhibitors of AChE combining pyridine, acylhydrazone and N-benzylpiperidine fragments were developed in this work. pyridine 38-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 31585263-3 2019 Some new inhibitors of AChE combining pyridine, acylhydrazone and N-benzylpiperidine fragments were developed in this work. 10H-phenothiazine-1-acylhydrazone 48-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 31585263-3 2019 Some new inhibitors of AChE combining pyridine, acylhydrazone and N-benzylpiperidine fragments were developed in this work. 1-benzylpiperidine 66-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 31585263-6 2019 The higher activity with an intermediate alkyl chain substitution indicates a new binding mode of inhibitor with AChE. Alkanesulfonates 41-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 31593690-3 2019 In this study, the inhibitory effects of a synthetic phenazine dye, methylene violet 3RAX (also known as diethyl safranine) on human erythrocyte AChE and human plasma BChE were tested and also its inhibitory mechanisms for both enzymes were studied in detail. Phenazines 53-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 31593690-3 2019 In this study, the inhibitory effects of a synthetic phenazine dye, methylene violet 3RAX (also known as diethyl safranine) on human erythrocyte AChE and human plasma BChE were tested and also its inhibitory mechanisms for both enzymes were studied in detail. methylene violet 68-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 31593690-3 2019 In this study, the inhibitory effects of a synthetic phenazine dye, methylene violet 3RAX (also known as diethyl safranine) on human erythrocyte AChE and human plasma BChE were tested and also its inhibitory mechanisms for both enzymes were studied in detail. safranine T 105-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 31593690-4 2019 Kinetic analyses showed that methylene violet 3RAX acts as a hyperbolic noncompetitive inhibitor of AChE with Ki value of 1.58 +- 0.36 muM; alpha = 1; beta = 0.12 +- 0.0003. methylene violet 29-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 31593690-6 2019 In conclusion, methylene violet 3RAX which is a highly effective inhibitor of both human AChE and human BChE with Ki values in low micromolar range may be a promising candidate for the treatment of Alzheimer"s disease. methylene violet 15-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 31561043-4 2019 In particular, compound 49 containing 2,4-difluoro substitution at terminal phenyl ring considered as most potential lead with inhibition of acetylcholinesterase (hAChE, IC50 = 0.054 muM), butyrylcholinesterase (hBChE, IC50 = 0.787 muM) and beta-secretase-1 (hBACE-1, IC50 = 0.098 muM). 2,4-difluoro 38-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-168 31561043-6 2019 Also, 48 and 49 showed significant displacement of propidium iodide from the peripheral anionic site (PAS) of hAChE, excellent blood-brain barrier (BBB) permeability in parallel artificial membrane permeation assay (PAMPA), and neuroprotective ability against SH-SY5Y neuroblastoma cell lines. Propidium 51-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-115 31561043-7 2019 Further, 49 also exhibited anti-Abeta aggregation activity in self- and AChE-induced thioflavin T assay, which was ascertained by morphological characterization by atomic force microscopy (AFM). thioflavin T 85-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 31885593-5 2019 It is known that acetylcholinesterase belongs to the same group of hydrolases enzymes as lipases and it cleaves indoxyl acetate, so we assume indoxyl acetate could report a similar reaction with lipase. indoxyl acetate 112-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 31885593-5 2019 It is known that acetylcholinesterase belongs to the same group of hydrolases enzymes as lipases and it cleaves indoxyl acetate, so we assume indoxyl acetate could report a similar reaction with lipase. indoxyl acetate 142-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 30727776-3 2019 The 3-(4-(dimethylamino)phenyl)-7-aminoethoxy-coumarin (6a) was considered a hit, showing good AChE inhibition potency (IC50 = 20 nM) and selectivity (IC50 BuChE/AChE = 354), quite similar to the reference drug donepezil (IC50 = 6 nM; IC50 BuChE/AChE = 365), also presenting antioxidant properties, low citotoxicity and good-predicted ADMET properties. 3-(4-(dimethylamino)phenyl)-7-aminoethoxy-coumarin 4-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-166 30734597-0 2019 Inhibition of acetylcholinesterase and butyrylcholinesterase with uracil derivatives: kinetic and computational studies. Uracil 66-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 30734597-5 2019 Being diverse of the classical AChE and BuChE inhibitors, the investigated uracil derivatives may be used as lead molecules for designing new therapeutically effective enzyme inhibitors. Uracil 75-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 31074292-0 2019 Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach. 7-methoxytacrine-4-pyridinealdoxime 50-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 31074292-0 2019 Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach. 4-pa 87-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 31074292-0 2019 Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach. Obidoxime Chloride 104-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 31074292-1 2019 7-methoxytacrine-4-pyridinealdoxime (7-MEOTA-4-PA, named hybrid 5C) is a compound formerly synthesized and evaluated in vitro, together with 4-pyridine aldoxime (4-PA) and commercial reactivators of acetylcholinesterase (AChE). 7-methoxytacrine-4-pyridinealdoxime 0-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-219 31074292-1 2019 7-methoxytacrine-4-pyridinealdoxime (7-MEOTA-4-PA, named hybrid 5C) is a compound formerly synthesized and evaluated in vitro, together with 4-pyridine aldoxime (4-PA) and commercial reactivators of acetylcholinesterase (AChE). 7-methoxytacrine-4-pyridinealdoxime 0-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 221-225 31074292-1 2019 7-methoxytacrine-4-pyridinealdoxime (7-MEOTA-4-PA, named hybrid 5C) is a compound formerly synthesized and evaluated in vitro, together with 4-pyridine aldoxime (4-PA) and commercial reactivators of acetylcholinesterase (AChE). 7-meota-4-pa 37-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-219 31074292-1 2019 7-methoxytacrine-4-pyridinealdoxime (7-MEOTA-4-PA, named hybrid 5C) is a compound formerly synthesized and evaluated in vitro, together with 4-pyridine aldoxime (4-PA) and commercial reactivators of acetylcholinesterase (AChE). 7-meota-4-pa 37-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 221-225 31074292-1 2019 7-methoxytacrine-4-pyridinealdoxime (7-MEOTA-4-PA, named hybrid 5C) is a compound formerly synthesized and evaluated in vitro, together with 4-pyridine aldoxime (4-PA) and commercial reactivators of acetylcholinesterase (AChE). 4-pa 45-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-219 31074292-1 2019 7-methoxytacrine-4-pyridinealdoxime (7-MEOTA-4-PA, named hybrid 5C) is a compound formerly synthesized and evaluated in vitro, together with 4-pyridine aldoxime (4-PA) and commercial reactivators of acetylcholinesterase (AChE). 4-pa 45-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 221-225 31074292-3 2019 To investigate these interactions, theoretical results from docking were first compared with experimental data of hybrid 5C, 4-PA, and two commercial oximes, on the reactivation of human AChE (HssAChE) inhibited by VX. 4-pa 125-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 31074292-3 2019 To investigate these interactions, theoretical results from docking were first compared with experimental data of hybrid 5C, 4-PA, and two commercial oximes, on the reactivation of human AChE (HssAChE) inhibited by VX. Oximes 150-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 31479951-12 2019 The active metabolites of Cordyceps were thus evaluated as the potential inhibitors for the AChE enzyme, and the 5-Carboxy-2"-deoxyuridine compound can inhibit the activity of the AChE enzyme. 5-carboxy-2'-deoxyuridine 113-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 31479951-12 2019 The active metabolites of Cordyceps were thus evaluated as the potential inhibitors for the AChE enzyme, and the 5-Carboxy-2"-deoxyuridine compound can inhibit the activity of the AChE enzyme. 5-carboxy-2'-deoxyuridine 113-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 31550630-4 2019 In the absence of OPs, acetylcholinesterase (AChE) hydrolyzed acetylcholine chloride (ATCh) into choline (TCh) and acetate. Acetylcholine 62-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 31550630-4 2019 In the absence of OPs, acetylcholinesterase (AChE) hydrolyzed acetylcholine chloride (ATCh) into choline (TCh) and acetate. Acetylcholine 86-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 31550630-4 2019 In the absence of OPs, acetylcholinesterase (AChE) hydrolyzed acetylcholine chloride (ATCh) into choline (TCh) and acetate. Acetylcholine 86-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 31550630-4 2019 In the absence of OPs, acetylcholinesterase (AChE) hydrolyzed acetylcholine chloride (ATCh) into choline (TCh) and acetate. Choline 29-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 31550630-4 2019 In the absence of OPs, acetylcholinesterase (AChE) hydrolyzed acetylcholine chloride (ATCh) into choline (TCh) and acetate. thiocarbohydrazide 87-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 31832335-5 2019 Also, the inhibition effects of usnic acid were tested against some metabolic enzymes including acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) linked to neurodegenerative diseases. usnic acid 32-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 31703066-5 2019 The results show that OPs penetrated the model blood brain barrier (BBB) and inhibited AChE activity. Organophosphates 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 31560517-5 2019 The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity. Thiocholine 4-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 31560517-5 2019 The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity. Thiocholine 4-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 31560517-5 2019 The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity. Thiocholine 4-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 310-314 31560517-5 2019 The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity. Acetylthiocholine 91-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 31560517-5 2019 The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity. Acetylthiocholine 91-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 31560517-5 2019 The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity. Acetylthiocholine 91-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 310-314 31560517-5 2019 The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity. Acetylthiocholine 110-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 31560517-5 2019 The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity. Acetylthiocholine 110-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 31560517-5 2019 The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity. Acetylthiocholine 110-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 310-314 31560517-5 2019 The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity. Cadmium 137-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 31560517-5 2019 The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity. Cadmium 137-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 31560517-5 2019 The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity. Cadmium 137-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 310-314 31560517-5 2019 The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity. 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol 155-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 31560517-5 2019 The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity. 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol 155-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 31560517-5 2019 The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity. 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol 155-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 310-314 31560517-5 2019 The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity. Chlorpyrifos 237-249 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 31560517-5 2019 The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity. Chlorpyrifos 237-249 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 31560517-5 2019 The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity. Chlorpyrifos 237-249 acetylcholinesterase (Cartwright blood group) Homo sapiens 310-314 31560517-5 2019 The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity. Thiocholine 97-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 31560517-5 2019 The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity. Thiocholine 97-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 31560517-5 2019 The thiocholine generated from acetylcholinesterase (AChE)-induced catalyzed hydrolysis of acetylthiocholine (ATCh) efficiently directed CdS QDs away from PPT/ITO via electrostatic repulsion, subsequently decreasing PEC current, whereas chlorpyrifos prohibited the generation of thiocholine through inhibiting AChE activity. Thiocholine 97-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 310-314 30918344-5 2019 Here we report that donepezil, an acetylcholinesterase inhibitor (AChEI) developed for the treatment of Alzheimer"s disease (AD), significantly promotes OPC to OL differentiation. Donepezil 20-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 31675671-2 2019 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are known to be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ACh). Serine 77-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 31675671-2 2019 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are known to be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ACh). Acetylcholine 136-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 31675671-2 2019 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are known to be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ACh). Acetylcholine 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 31522735-1 2019 Acetylcholinesterase (AChE), an efficient biocatalyst known to hydrolyze the neurotransmitter acetylcholine, could be inactivated in the presence of insecticides, nerve agents or other drug inhibitors to thus result in disrupted neurotransmission. Acetylcholine 94-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 31522735-1 2019 Acetylcholinesterase (AChE), an efficient biocatalyst known to hydrolyze the neurotransmitter acetylcholine, could be inactivated in the presence of insecticides, nerve agents or other drug inhibitors to thus result in disrupted neurotransmission. Acetylcholine 94-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 31938465-0 2020 Cysteine-Targeted Insecticides against A. gambiae Acetylcholinesterase Are Neither Selective nor Reversible Inhibitors. Cysteine 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 31938465-1 2020 Acetylcholinesterase cysteine-targeted insecticides against malaria vector Anopheles gambia and other mosquitos have already been introduced. Cysteine 21-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 31479975-0 2019 Neurobehavioral investigation and acetylcholinesterase inhibitory activity study for some new coumarin derivatives. coumarin 94-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 31766252-3 2019 Kinetic studies against AChE, BChE, and beta-secretase (BACE-1) were performed on 2-(3-fluorophenyl)- (3b) and 2-(4-chlorophenyl)-6-[(4-trifluoromethylphenyl)hydrazonomethyl]furo[3,2-h]chromen-5-one (3e) complemented with molecular docking (in silico) to determine plausible protein-ligand interactions on a molecular level. flutrimazole 82-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 31766252-3 2019 Kinetic studies against AChE, BChE, and beta-secretase (BACE-1) were performed on 2-(3-fluorophenyl)- (3b) and 2-(4-chlorophenyl)-6-[(4-trifluoromethylphenyl)hydrazonomethyl]furo[3,2-h]chromen-5-one (3e) complemented with molecular docking (in silico) to determine plausible protein-ligand interactions on a molecular level. 4-methyl-9-phenyl-8-(thiophene-2-carbonyl)-furo(2,3-h)chromen-2-one 111-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 30978295-11 2019 Parent and oxon metabolites decreased acetylcholinesterase activity, but comparable acetylcholinesterase inhibition by eserine did not mimic OP effects on cytokines. oxon 11-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 31832335-5 2019 Also, the inhibition effects of usnic acid were tested against some metabolic enzymes including acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) linked to neurodegenerative diseases. usnic acid 32-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 31832335-8 2019 Furthermore, usnic acid showed the potent inhibition profiles against AChE (IC50: 1.273 nM) and BChE (IC50: 0.239 nM) enzymes. usnic acid 13-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 29860891-0 2019 The behavior of some chalcones on acetylcholinesterase and carbonic anhydrase activity. Chalcones 21-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 31650189-7 2019 Reversal by administration of the acetylcholinesterase inhibitor neostigmine reduces the incidence of residual neuromuscular block to 15.4%, in combination with calibrated acceleromyography to 3.3%. Neostigmine 65-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 31470200-0 2019 Pyrazole[3,4-d]pyridazine derivatives: Molecular docking and explore of acetylcholinesterase and carbonic anhydrase enzymes inhibitors as anticholinergics potentials. pyrazole[3,4-d]pyridazine 0-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 29860891-6 2019 We also investigated the inhibition of seven chalcones toward hCA I, hCA II, and AChE. Chalcones 45-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 29860891-7 2019 The chalcones were effective inhibitors of the cytosolic CA isoforms (hCA I and hCA II) and AChE with Ki values in the range of 1.83-7.05 muM for hCA I, 0.59-5.50 muM for hCA II, and 0.61-86.11 muM for AChE. Chalcones 4-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 29860891-7 2019 The chalcones were effective inhibitors of the cytosolic CA isoforms (hCA I and hCA II) and AChE with Ki values in the range of 1.83-7.05 muM for hCA I, 0.59-5.50 muM for hCA II, and 0.61-86.11 muM for AChE. Chalcones 4-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-206 31854179-0 2019 Starring role of acetylcholinesterase from medicinal plants on lactate dehydrogenase production in cytotoxic hepatic cells. Lactic Acid 63-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 31421177-2 2019 Herein, two enzymes acetylcholinesterase and choline oxidase were covalently immobilized over the gold nanoparticles (AuNPs) embedded graphene oxide (GO; 2D carbon material) nanocomposite modified ITO coated glass plate. graphene oxide 134-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 31421177-2 2019 Herein, two enzymes acetylcholinesterase and choline oxidase were covalently immobilized over the gold nanoparticles (AuNPs) embedded graphene oxide (GO; 2D carbon material) nanocomposite modified ITO coated glass plate. graphene oxide 150-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 31421177-2 2019 Herein, two enzymes acetylcholinesterase and choline oxidase were covalently immobilized over the gold nanoparticles (AuNPs) embedded graphene oxide (GO; 2D carbon material) nanocomposite modified ITO coated glass plate. Carbon 157-163 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 31581370-0 2019 Synthesis of novel bis-sulfone derivatives and their inhibition properties on some metabolic enzymes including carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase. bis-sulfone 19-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-151 31581370-4 2019 Here, we report the synthesis and testing of novel bis-sulfone compound-based hybrid scaffold of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors for the development of novel molecules toward the therapy of Alzheimer"s disease. bis-sulfone 51-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 31581370-4 2019 Here, we report the synthesis and testing of novel bis-sulfone compound-based hybrid scaffold of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors for the development of novel molecules toward the therapy of Alzheimer"s disease. bis-sulfone 51-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 31581370-6 2019 The results showed that novel bis-sulfone derivatives can have promising drug potential for glaucoma, leukemia, epilepsy, and Alzheimer"s disease, which are associated with the high enzymatic activity of hCA I, hCA II, AChE, and BChE enzymes. bis-sulfone 30-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 219-223 31425905-7 2019 Further, to understand the nature of interactions and the conformational flexibility of piperine in the active site of recombinant human acetylcholinesterase (rhAChE), molecular docking analysis has been performed. piperine 88-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 31575743-6 2019 These inhibitors, with high selectivity against human acetylcholinesterase and low to no toxicity in human cells and in mice, act synergistically with the OPs diazinon and malathion to reduce the amount of OP required to kill L. cuprina by up to 16-fold and abolish resistance. Malathion 172-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 31491736-6 2019 According to theoretical analysis, hydrogen bonding, van der Waals, and hydrophobic forces are the main binding interactions for each V(V) complex and AChE. Hydrogen 35-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 31717775-1 2019 The joint toxicities of [BMIM]BF4, [BMIM]PF6, and [HMIM]BF4 on acetylcholinesterase (AChE) were systematically investigated by using a progressive approach from 1D single effect point, 2D concentration-response curve (CRC), to 3D equivalent-surface (ES) level. nitrosonium tetrafluoroborate 50-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 31491074-3 2019 The potential leads 6g and 10f exhibited balanced inhibitory profiles against all the targets, with a substantial displacement of propidium iodide from the peripheral anionic site of hAChE. Propidium 130-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-188 31615442-6 2019 Expression of acetylcholinesterase (AChE) and choline acetyltransferase (ChAT) was measured by quantitative real-time PCR and western blot. Choline 20-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 31362050-6 2019 Additionally, the degree of bioconjugation of the HSA-phenthoate is positively associated with the enzymatic activity of target AChE, which may be attributed to the competitive reactions between HSA and AChE. hsa-phenthoate 50-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 31362050-6 2019 Additionally, the degree of bioconjugation of the HSA-phenthoate is positively associated with the enzymatic activity of target AChE, which may be attributed to the competitive reactions between HSA and AChE. hsa-phenthoate 50-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 203-207 31532667-0 2019 One-Step Facile Synthesis of Nitrogen-Doped Carbon Dots: A Ratiometric Fluorescent Probe for Evaluation of Acetylcholinesterase Activity and Detection of Organophosphorus Pesticides in Tap Water and Food. Nitrogen 29-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 31532667-0 2019 One-Step Facile Synthesis of Nitrogen-Doped Carbon Dots: A Ratiometric Fluorescent Probe for Evaluation of Acetylcholinesterase Activity and Detection of Organophosphorus Pesticides in Tap Water and Food. Carbon 44-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 31532667-2 2019 In this study, a highly selective and sensitive ratiometric fluorescent probe was innovatively fabricated for the evaluation of AChE activity and the determination of OPs in tap water and food on the basis of the inner filter effect (IFE) between nitrogen-doped carbon dots (N-CDs) and 2,3-diaminophenazine (DAP). Nitrogen 247-255 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 31532667-2 2019 In this study, a highly selective and sensitive ratiometric fluorescent probe was innovatively fabricated for the evaluation of AChE activity and the determination of OPs in tap water and food on the basis of the inner filter effect (IFE) between nitrogen-doped carbon dots (N-CDs) and 2,3-diaminophenazine (DAP). n-cds 275-280 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 31532667-5 2019 Upon the addition of AChE and choline oxidase, acetylcholine was catalyzed to produce choline that was further oxidized to produce H2O2. Acetylcholine 47-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 31532667-5 2019 Upon the addition of AChE and choline oxidase, acetylcholine was catalyzed to produce choline that was further oxidized to produce H2O2. Choline 53-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 31532667-5 2019 Upon the addition of AChE and choline oxidase, acetylcholine was catalyzed to produce choline that was further oxidized to produce H2O2. Hydrogen Peroxide 131-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 31532667-8 2019 OPs irreversibly impeded the catalytic activity of AChE, finally leading to the decrease of DAP amount and the variation of ratiometric fluorescent signal. 2,3-diaminophenazine 92-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 31175926-1 2019 Pyridostigmine bromide (PB), an acetylcholinesterase (AChE) enzyme inhibitor. Pyridostigmine Bromide 0-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 31351393-2 2019 Here we describe the synthesis and multitarget biological profiling of a new class of compounds designed by molecular hybridization of an NMDA receptor antagonist fluorobenzohomoadamantanamine with the potent acetylcholinesterase (AChE) inhibitor 6-chlorotacrine, using two different linker lengths and linkage positions, to preserve or not the memantine-like polycyclic unsubstituted primary amine. fluorobenzohomoadamantanamine 163-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 231-235 31351393-2 2019 Here we describe the synthesis and multitarget biological profiling of a new class of compounds designed by molecular hybridization of an NMDA receptor antagonist fluorobenzohomoadamantanamine with the potent acetylcholinesterase (AChE) inhibitor 6-chlorotacrine, using two different linker lengths and linkage positions, to preserve or not the memantine-like polycyclic unsubstituted primary amine. 6-chlorotacrine 247-262 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-229 31351393-2 2019 Here we describe the synthesis and multitarget biological profiling of a new class of compounds designed by molecular hybridization of an NMDA receptor antagonist fluorobenzohomoadamantanamine with the potent acetylcholinesterase (AChE) inhibitor 6-chlorotacrine, using two different linker lengths and linkage positions, to preserve or not the memantine-like polycyclic unsubstituted primary amine. 6-chlorotacrine 247-262 acetylcholinesterase (Cartwright blood group) Homo sapiens 231-235 31351393-2 2019 Here we describe the synthesis and multitarget biological profiling of a new class of compounds designed by molecular hybridization of an NMDA receptor antagonist fluorobenzohomoadamantanamine with the potent acetylcholinesterase (AChE) inhibitor 6-chlorotacrine, using two different linker lengths and linkage positions, to preserve or not the memantine-like polycyclic unsubstituted primary amine. Memantine 345-354 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-229 31351393-2 2019 Here we describe the synthesis and multitarget biological profiling of a new class of compounds designed by molecular hybridization of an NMDA receptor antagonist fluorobenzohomoadamantanamine with the potent acetylcholinesterase (AChE) inhibitor 6-chlorotacrine, using two different linker lengths and linkage positions, to preserve or not the memantine-like polycyclic unsubstituted primary amine. Memantine 345-354 acetylcholinesterase (Cartwright blood group) Homo sapiens 231-235 31351393-2 2019 Here we describe the synthesis and multitarget biological profiling of a new class of compounds designed by molecular hybridization of an NMDA receptor antagonist fluorobenzohomoadamantanamine with the potent acetylcholinesterase (AChE) inhibitor 6-chlorotacrine, using two different linker lengths and linkage positions, to preserve or not the memantine-like polycyclic unsubstituted primary amine. polycyclic unsubstituted 360-384 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-229 31351393-2 2019 Here we describe the synthesis and multitarget biological profiling of a new class of compounds designed by molecular hybridization of an NMDA receptor antagonist fluorobenzohomoadamantanamine with the potent acetylcholinesterase (AChE) inhibitor 6-chlorotacrine, using two different linker lengths and linkage positions, to preserve or not the memantine-like polycyclic unsubstituted primary amine. polycyclic unsubstituted 360-384 acetylcholinesterase (Cartwright blood group) Homo sapiens 231-235 31351393-2 2019 Here we describe the synthesis and multitarget biological profiling of a new class of compounds designed by molecular hybridization of an NMDA receptor antagonist fluorobenzohomoadamantanamine with the potent acetylcholinesterase (AChE) inhibitor 6-chlorotacrine, using two different linker lengths and linkage positions, to preserve or not the memantine-like polycyclic unsubstituted primary amine. Amines 187-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-229 31351393-2 2019 Here we describe the synthesis and multitarget biological profiling of a new class of compounds designed by molecular hybridization of an NMDA receptor antagonist fluorobenzohomoadamantanamine with the potent acetylcholinesterase (AChE) inhibitor 6-chlorotacrine, using two different linker lengths and linkage positions, to preserve or not the memantine-like polycyclic unsubstituted primary amine. Amines 187-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 231-235 31398669-9 2019 AChE activity was significantly reduced to 30.5%-50.6% of baseline activity during physostigmine salicylate infusion. physostigmine salicylate 83-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 31398669-12 2019 Physostigmine inhibited AChE activity with a sigmoidal concentration-response effect. Physostigmine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 31444085-3 2019 The results revealed that the tertiary amines and methylene chain length significantly affected the eeAChE inhibitory potency, in particular, compound TM-14 showed the best eeAChE inhibitory activity with IC50 value of 2.9 muM, in addition, both kinetic analysis of AChE inhibition and docking study displayed that TM-14 could simultaneously bind to the catalytic active site and peripheral anionic site of AChE. Amines 39-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 31444085-7 2019 Therefore, the structure-active-relationship of 2-acetylphenol-donepezil hybrids could encourage the development of multifunction agents with selective AChE inhibition or selective MAO-B inhibition for the treatment of Alzheimer"s disease. 2'-Hydroxyacetophenone 48-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 31444085-7 2019 Therefore, the structure-active-relationship of 2-acetylphenol-donepezil hybrids could encourage the development of multifunction agents with selective AChE inhibition or selective MAO-B inhibition for the treatment of Alzheimer"s disease. Donepezil 63-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 31265934-0 2019 Carboxamides vs. methanimines: Crystal structures, binding interactions, photophysical studies, and biological evaluation of (indazole-5-yl)methanimines as monoamine oxidase B and acetylcholinesterase inhibitors. carboxamides 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-200 31265934-0 2019 Carboxamides vs. methanimines: Crystal structures, binding interactions, photophysical studies, and biological evaluation of (indazole-5-yl)methanimines as monoamine oxidase B and acetylcholinesterase inhibitors. (indazole-5-yl)methanimines 125-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-200 31556693-0 2019 Tacroximes: novel unique compounds for the recovery of organophosphorus-inhibited acetylcholinesterase. Organophosphates 55-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 31556693-1 2019 Aim: Organophosphorus compounds are irreversible inhibitors of acetylcholinesterase. Organophosphates 5-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 31556693-6 2019 These reactivators of acetylcholinesterase have balanced physicochemical properties, and should be able to cross the blood-brain barrier with a slightly lowered cytotoxicity profile compared to reference tacrine. Tacrine 204-211 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 31478295-0 2019 Inhibition profiles of Voriconazole against acetylcholinesterase, alpha-glycosidase, and human carbonic anhydrase I and II isoenzymes. Voriconazole 23-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 31478295-1 2019 In this work, the inhibitory activity of Voriconazole was measured against some metabolic enzymes, including human carbonic anhydrase (hCA) I and II isoenzymes, acetylcholinesterase (AChE), and alpha-glycosidase; the results were compared with standard compounds including acetazolamide, tacrine, and acarbose. Voriconazole 41-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-181 31478295-1 2019 In this work, the inhibitory activity of Voriconazole was measured against some metabolic enzymes, including human carbonic anhydrase (hCA) I and II isoenzymes, acetylcholinesterase (AChE), and alpha-glycosidase; the results were compared with standard compounds including acetazolamide, tacrine, and acarbose. Voriconazole 41-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-187 31478295-5 2019 In addition, the Voriconazole compound demonstrated excellent inhibitory effects against AChE and hCA isoforms I and II. Voriconazole 17-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 31478295-6 2019 Voriconazole had Ki values of 29.13 +- 3.57 nM against hCA I, 15.92 +- 1.90 nM against hCA II, and 10.50 +- 2.46 nM against AChE. Voriconazole 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 31623258-2 2019 Acetylcholinesterase (AChE) enzyme was immobilized onto three gold interfaces with different morphologies, and the sensor response to chloroform was measured. Chloroform 134-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 31623258-2 2019 Acetylcholinesterase (AChE) enzyme was immobilized onto three gold interfaces with different morphologies, and the sensor response to chloroform was measured. Chloroform 134-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 31175926-1 2019 Pyridostigmine bromide (PB), an acetylcholinesterase (AChE) enzyme inhibitor. Pyridostigmine Bromide 0-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 31175926-1 2019 Pyridostigmine bromide (PB), an acetylcholinesterase (AChE) enzyme inhibitor. Pyridostigmine Bromide 24-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 31175926-1 2019 Pyridostigmine bromide (PB), an acetylcholinesterase (AChE) enzyme inhibitor. Pyridostigmine Bromide 24-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 31175926-7 2019 PB effects in quantity of enzyme AChE, mortality rate, oxidative stress markers, and DNA damage were assessed. Pyridostigmine Bromide 0-2 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 31175926-10 2019 However, AA-PBMCs seemed more sensitive to PB exposure, in a protein decrease of the enzyme AChE by 10%, cell-mortality at concentrations of 20 and 40 ng/mL, protein carbonylation, and DNA damage, as analyzed by the Comet assay. Pyridostigmine Bromide 12-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 31575200-1 2019 This article reports on a frequency domain analysis of quasielastic neutron scattering spectra from free and Huperzine-A-inhibited human acetylcholinesterase, extending a recent time domain analysis of the same experimental data [M. Saouessi et al., J. Chem. huperzine A 109-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 31596141-0 2019 Design, synthesis and molecular modeling of isothiochromanone derivatives as acetylcholinesterase inhibitors. isothiochromanone 44-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 31596141-1 2019 Aim: A series of novel isothio- and isoselenochromanone derivatives bearing N-benzyl pyridinium moiety were designed, synthesized and evaluated as acetylcholinesterase (AChE) inhibitors. isoselenochromanone 36-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 31596141-1 2019 Aim: A series of novel isothio- and isoselenochromanone derivatives bearing N-benzyl pyridinium moiety were designed, synthesized and evaluated as acetylcholinesterase (AChE) inhibitors. isoselenochromanone 36-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 31596141-1 2019 Aim: A series of novel isothio- and isoselenochromanone derivatives bearing N-benzyl pyridinium moiety were designed, synthesized and evaluated as acetylcholinesterase (AChE) inhibitors. Pyridinium Compounds 76-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 31596141-1 2019 Aim: A series of novel isothio- and isoselenochromanone derivatives bearing N-benzyl pyridinium moiety were designed, synthesized and evaluated as acetylcholinesterase (AChE) inhibitors. Pyridinium Compounds 76-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 31482681-0 2019 Oxidase-Like Fe-N-C Single-Atom Nanozymes for the Detection of Acetylcholinesterase Activity. fe-n-c 13-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 31482681-5 2019 Besides, the Fe-N-C SAzymes are applied in biosensor areas to evaluate the activity of acetylcholinesterase based on the inhibition toward nanozyme activity by thiols. fe-n-c 13-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 31482681-5 2019 Besides, the Fe-N-C SAzymes are applied in biosensor areas to evaluate the activity of acetylcholinesterase based on the inhibition toward nanozyme activity by thiols. Sulfhydryl Compounds 160-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 31561628-1 2019 A series of 7-halogeno- (X = F, Cl, Br) and 7-methoxy-substituted acetylated 6-iodo-3-O-flavonol glycosides were prepared, and evaluated for inhibitory effect in vitro against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities. 7-methoxy-substituted acetylated 6-iodo-3-o-flavonol glycosides 44-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-196 31561628-1 2019 A series of 7-halogeno- (X = F, Cl, Br) and 7-methoxy-substituted acetylated 6-iodo-3-O-flavonol glycosides were prepared, and evaluated for inhibitory effect in vitro against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities. 7-methoxy-substituted acetylated 6-iodo-3-o-flavonol glycosides 44-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-202 31448915-0 2019 A Flexible Acetylcholinesterase-Modified Graphene for Chiral Pesticide Sensor. Graphite 41-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 31448915-3 2019 Here, using chiral pesticide molecules as an example, we realized a highly sensitive graphene chiral sensor by modification with acetylcholinesterase (AChE). Graphite 85-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-149 31448915-3 2019 Here, using chiral pesticide molecules as an example, we realized a highly sensitive graphene chiral sensor by modification with acetylcholinesterase (AChE). Graphite 85-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 31448915-4 2019 Quantum chemical simulations indicate that the inhibition effect of the enantiomer on AChE was transferred to graphene, which allowed for the electrical detection of chiral molecules. Graphite 110-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 31252259-1 2019 A stable and sensitive electrochemical acetylcholinesterase (AChE) biosensor for detection of organophosphorus pesticides (OPs) was developed by doping Au nanorods (AuNRs)@mesoporous SiO2 (MS) core-shell nanoparticles into CS/TiO2-CS (CS denotes for chitosan) immobilization matrix. organophosphorus 94-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 31252259-1 2019 A stable and sensitive electrochemical acetylcholinesterase (AChE) biosensor for detection of organophosphorus pesticides (OPs) was developed by doping Au nanorods (AuNRs)@mesoporous SiO2 (MS) core-shell nanoparticles into CS/TiO2-CS (CS denotes for chitosan) immobilization matrix. organophosphorus 94-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 31252259-1 2019 A stable and sensitive electrochemical acetylcholinesterase (AChE) biosensor for detection of organophosphorus pesticides (OPs) was developed by doping Au nanorods (AuNRs)@mesoporous SiO2 (MS) core-shell nanoparticles into CS/TiO2-CS (CS denotes for chitosan) immobilization matrix. OPS 123-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 31252259-1 2019 A stable and sensitive electrochemical acetylcholinesterase (AChE) biosensor for detection of organophosphorus pesticides (OPs) was developed by doping Au nanorods (AuNRs)@mesoporous SiO2 (MS) core-shell nanoparticles into CS/TiO2-CS (CS denotes for chitosan) immobilization matrix. OPS 123-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 31252259-1 2019 A stable and sensitive electrochemical acetylcholinesterase (AChE) biosensor for detection of organophosphorus pesticides (OPs) was developed by doping Au nanorods (AuNRs)@mesoporous SiO2 (MS) core-shell nanoparticles into CS/TiO2-CS (CS denotes for chitosan) immobilization matrix. Gold 152-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 31252259-1 2019 A stable and sensitive electrochemical acetylcholinesterase (AChE) biosensor for detection of organophosphorus pesticides (OPs) was developed by doping Au nanorods (AuNRs)@mesoporous SiO2 (MS) core-shell nanoparticles into CS/TiO2-CS (CS denotes for chitosan) immobilization matrix. Gold 152-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 31252259-1 2019 A stable and sensitive electrochemical acetylcholinesterase (AChE) biosensor for detection of organophosphorus pesticides (OPs) was developed by doping Au nanorods (AuNRs)@mesoporous SiO2 (MS) core-shell nanoparticles into CS/TiO2-CS (CS denotes for chitosan) immobilization matrix. mesoporous 172-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 31252259-1 2019 A stable and sensitive electrochemical acetylcholinesterase (AChE) biosensor for detection of organophosphorus pesticides (OPs) was developed by doping Au nanorods (AuNRs)@mesoporous SiO2 (MS) core-shell nanoparticles into CS/TiO2-CS (CS denotes for chitosan) immobilization matrix. mesoporous 172-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 31252259-1 2019 A stable and sensitive electrochemical acetylcholinesterase (AChE) biosensor for detection of organophosphorus pesticides (OPs) was developed by doping Au nanorods (AuNRs)@mesoporous SiO2 (MS) core-shell nanoparticles into CS/TiO2-CS (CS denotes for chitosan) immobilization matrix. Silicon Dioxide 183-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 31252259-1 2019 A stable and sensitive electrochemical acetylcholinesterase (AChE) biosensor for detection of organophosphorus pesticides (OPs) was developed by doping Au nanorods (AuNRs)@mesoporous SiO2 (MS) core-shell nanoparticles into CS/TiO2-CS (CS denotes for chitosan) immobilization matrix. Silicon Dioxide 183-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 31252259-1 2019 A stable and sensitive electrochemical acetylcholinesterase (AChE) biosensor for detection of organophosphorus pesticides (OPs) was developed by doping Au nanorods (AuNRs)@mesoporous SiO2 (MS) core-shell nanoparticles into CS/TiO2-CS (CS denotes for chitosan) immobilization matrix. Cesium 223-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 31252259-1 2019 A stable and sensitive electrochemical acetylcholinesterase (AChE) biosensor for detection of organophosphorus pesticides (OPs) was developed by doping Au nanorods (AuNRs)@mesoporous SiO2 (MS) core-shell nanoparticles into CS/TiO2-CS (CS denotes for chitosan) immobilization matrix. Cesium 223-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 31252259-1 2019 A stable and sensitive electrochemical acetylcholinesterase (AChE) biosensor for detection of organophosphorus pesticides (OPs) was developed by doping Au nanorods (AuNRs)@mesoporous SiO2 (MS) core-shell nanoparticles into CS/TiO2-CS (CS denotes for chitosan) immobilization matrix. tio2-cs 226-233 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 31252259-1 2019 A stable and sensitive electrochemical acetylcholinesterase (AChE) biosensor for detection of organophosphorus pesticides (OPs) was developed by doping Au nanorods (AuNRs)@mesoporous SiO2 (MS) core-shell nanoparticles into CS/TiO2-CS (CS denotes for chitosan) immobilization matrix. tio2-cs 226-233 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 31252259-1 2019 A stable and sensitive electrochemical acetylcholinesterase (AChE) biosensor for detection of organophosphorus pesticides (OPs) was developed by doping Au nanorods (AuNRs)@mesoporous SiO2 (MS) core-shell nanoparticles into CS/TiO2-CS (CS denotes for chitosan) immobilization matrix. Cesium 231-233 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 31252259-1 2019 A stable and sensitive electrochemical acetylcholinesterase (AChE) biosensor for detection of organophosphorus pesticides (OPs) was developed by doping Au nanorods (AuNRs)@mesoporous SiO2 (MS) core-shell nanoparticles into CS/TiO2-CS (CS denotes for chitosan) immobilization matrix. Cesium 231-233 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 31252259-5 2019 The matrix both before and after AChE immobilization had a mesoporous nanostructure. mesoporous 59-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 31252259-7 2019 The doping significantly enhanced the electro-conductivity of the TiO2-CS hydrogel, and dramatically improved the bioelectrocatalytic activity and OPs detection sensitivity of the AChE immobilized matrix. tio2-cs 66-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 31378596-1 2019 A series of benzamide derivatives 1-12 with various functional groups (-H, -Br, -F, -OCH3, -OC2H5, and -NO2) was synthesized using an economic, and facile Microwave-Assisted Organic Synthesis, and evaluated for acetylcholinesterase (ACHE) and butyrylcholinesterase (BCHE) activity in vitro. benzamide 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-231 31378596-1 2019 A series of benzamide derivatives 1-12 with various functional groups (-H, -Br, -F, -OCH3, -OC2H5, and -NO2) was synthesized using an economic, and facile Microwave-Assisted Organic Synthesis, and evaluated for acetylcholinesterase (ACHE) and butyrylcholinesterase (BCHE) activity in vitro. benzamide 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-237 31271801-8 2019 Docking simulations showed binding affinities of compounds 1 to 5 for hMAO-B were higher than those for hMAO-A or AChE and suggested these five chalcones form hydrogen bonds with MAO-B at Cys172 but that they do not form hydrogen bonds with hMAO-A or AChE. Hydrogen 159-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 31136966-1 2019 Chlorpyrifos (CPF) is an organophosphate pesticide widely used in agriculture, whose traditional and well-known mechanism of action is the inhibition of the enzyme Acetylcholinesterase (AChE). Chlorpyrifos 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-184 31220673-4 2019 Our study has shown that cryptolepine (1) and its 2-bromo-derivative 2 are dual inhibitors of acetylcholinesterase and butyrylcholinesterase, the enzymes which are involved in blocking the process of neurotransmission. cryptolepine 25-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 31220673-5 2019 Cryptolepine inhibits Electrophorus electricus acetylcholinesterase, recombinant human acetylcholinesterase and equine serum butyrylcholinesterase with IC50 values of 267, 485 and 699 nM, respectively. cryptolepine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 31220673-5 2019 Cryptolepine inhibits Electrophorus electricus acetylcholinesterase, recombinant human acetylcholinesterase and equine serum butyrylcholinesterase with IC50 values of 267, 485 and 699 nM, respectively. cryptolepine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 31220673-7 2019 The kinetic studies revealed that cryptolepine inhibits human acetylcholinesterase in a non-competitive manner, with ki value of 0.88 microM. cryptolepine 34-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 31220673-11 2019 The molecular modeling studies with AChE and BChE have shown that both alkaloids were tightly packed inside the active site gorge (site 1) via multiple pi-pi and cation-pi interactions. Alkaloids 71-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 31271946-6 2019 Compounds 44 and 67 produced significant displacement of propidium iodide from the peripheral anionic site (PAS) of AChE. Propidium 57-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 31271946-6 2019 Compounds 44 and 67 produced significant displacement of propidium iodide from the peripheral anionic site (PAS) of AChE. Aminosalicylic Acid 108-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 31280015-0 2019 Ultrasound-assisted synthesis of novel chalcone, heterochalcone and bis-chalcone derivatives and the evaluation of their antioxidant properties and as acetylcholinesterase inhibitors. Chalcone 39-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-171 31280015-0 2019 Ultrasound-assisted synthesis of novel chalcone, heterochalcone and bis-chalcone derivatives and the evaluation of their antioxidant properties and as acetylcholinesterase inhibitors. bis-chalcone 68-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-171 31284100-0 2019 The green synthesis and molecular docking of novel N-substituted rhodanines as effective inhibitors for carbonic anhydrase and acetylcholinesterase enzymes. n-substituted rhodanines 51-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 31288136-1 2019 In this study, 1,2,3-triazole substituted metal-free and metallo phthalocyanines (4, 5, 6) and their water soluble derivatives (4a, 5a, 6a) were designed, synthesized for the first time and tested in vitro on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Triazoles 15-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-229 31288136-1 2019 In this study, 1,2,3-triazole substituted metal-free and metallo phthalocyanines (4, 5, 6) and their water soluble derivatives (4a, 5a, 6a) were designed, synthesized for the first time and tested in vitro on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Triazoles 15-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 231-235 31288136-1 2019 In this study, 1,2,3-triazole substituted metal-free and metallo phthalocyanines (4, 5, 6) and their water soluble derivatives (4a, 5a, 6a) were designed, synthesized for the first time and tested in vitro on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Metals 42-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 209-229 31288136-1 2019 In this study, 1,2,3-triazole substituted metal-free and metallo phthalocyanines (4, 5, 6) and their water soluble derivatives (4a, 5a, 6a) were designed, synthesized for the first time and tested in vitro on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Metals 42-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 231-235 31288136-3 2019 Among the six phthalocyanines and starting compounds, 4a showed the most interesting profile as a submicromolar selective inhibitor of AChE (IC50 = 0.040 microM) and 5a showed the most effective inhibitor of BChE (IC50 = 0.1198 microM). phthalocyanine 14-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 31350127-0 2019 Comparative analysis of stilbene and benzofuran neolignan derivatives as acetylcholinesterase inhibitors with neuroprotective and anti-inflammatory activities. Stilbenes 24-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 31350127-0 2019 Comparative analysis of stilbene and benzofuran neolignan derivatives as acetylcholinesterase inhibitors with neuroprotective and anti-inflammatory activities. benzofuran neolignan 37-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 31350127-2 2019 The objective of this study was to investigate the structure-activity relationships of naturally occurring stilbene and benzofuran neolignan derivatives as acetylcholinesterase inhibitors. Stilbenes 107-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-176 31350127-2 2019 The objective of this study was to investigate the structure-activity relationships of naturally occurring stilbene and benzofuran neolignan derivatives as acetylcholinesterase inhibitors. benzofuran neolignan 120-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-176 31350127-4 2019 delta-Viniferin, pterostilbene trans-dehydrodimer, pallidol, grossamide, and boehmenan exerted acetylcholinesterase inhibitory potential. delta-viniferin 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 31350127-4 2019 delta-Viniferin, pterostilbene trans-dehydrodimer, pallidol, grossamide, and boehmenan exerted acetylcholinesterase inhibitory potential. Pterostilbene trans-dehydrodimer 17-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 31350127-4 2019 delta-Viniferin, pterostilbene trans-dehydrodimer, pallidol, grossamide, and boehmenan exerted acetylcholinesterase inhibitory potential. pallidol 51-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 31350127-4 2019 delta-Viniferin, pterostilbene trans-dehydrodimer, pallidol, grossamide, and boehmenan exerted acetylcholinesterase inhibitory potential. GROSSAMIDE 61-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 31350127-4 2019 delta-Viniferin, pterostilbene trans-dehydrodimer, pallidol, grossamide, and boehmenan exerted acetylcholinesterase inhibitory potential. boehmenan 77-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 31554781-1 2019 BACKGROUND Pyridostigmine is a quaternary amine parasympathomymetic which inhibits acetylcholinesterase for the treatment of various conditions such as myasthenia gravis. Pyridostigmine Bromide 11-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 31554781-1 2019 BACKGROUND Pyridostigmine is a quaternary amine parasympathomymetic which inhibits acetylcholinesterase for the treatment of various conditions such as myasthenia gravis. quaternary amine 31-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 31128750-1 2019 Quantitatively paper-based senor is performed with simple distance-readout on mixed cellulose ester (MCE) filter paper based on acetylcholinesterase (AChE)-mediated alginate hydrogel. cellulose ester 84-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 31128750-1 2019 Quantitatively paper-based senor is performed with simple distance-readout on mixed cellulose ester (MCE) filter paper based on acetylcholinesterase (AChE)-mediated alginate hydrogel. cellulose ester 84-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 31128750-1 2019 Quantitatively paper-based senor is performed with simple distance-readout on mixed cellulose ester (MCE) filter paper based on acetylcholinesterase (AChE)-mediated alginate hydrogel. Metergoline 101-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 31128750-1 2019 Quantitatively paper-based senor is performed with simple distance-readout on mixed cellulose ester (MCE) filter paper based on acetylcholinesterase (AChE)-mediated alginate hydrogel. Metergoline 101-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 31128750-1 2019 Quantitatively paper-based senor is performed with simple distance-readout on mixed cellulose ester (MCE) filter paper based on acetylcholinesterase (AChE)-mediated alginate hydrogel. Alginates 165-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 31128750-1 2019 Quantitatively paper-based senor is performed with simple distance-readout on mixed cellulose ester (MCE) filter paper based on acetylcholinesterase (AChE)-mediated alginate hydrogel. Alginates 165-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 31128750-2 2019 The method is accomplished with the aid of the inhibition effect of target samples on the AChE enzyme-catalyzed hydrolysis of acetylcholine, which changes the pH value of the solution to release Ca2+ and trigger alginate hydrogelation. Acetylcholine 126-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 31128750-2 2019 The method is accomplished with the aid of the inhibition effect of target samples on the AChE enzyme-catalyzed hydrolysis of acetylcholine, which changes the pH value of the solution to release Ca2+ and trigger alginate hydrogelation. Alginates 212-220 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 31276662-1 2019 Organophosphates (OPs) irreversibly inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 31276662-1 2019 Organophosphates (OPs) irreversibly inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Organophosphates 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 31276662-3 2019 Present study evaluates reactivation potency of two newly developed oximes, K456 and K733, against paraoxon (POX)-inhibited human-RBC-AChE and human-plasma-BChE in comparison to reported reactivator, pralidoxime (2-PAM). Oximes 68-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 31276662-3 2019 Present study evaluates reactivation potency of two newly developed oximes, K456 and K733, against paraoxon (POX)-inhibited human-RBC-AChE and human-plasma-BChE in comparison to reported reactivator, pralidoxime (2-PAM). 1,4-dihydroxyanthraquinone 76-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 31276662-3 2019 Present study evaluates reactivation potency of two newly developed oximes, K456 and K733, against paraoxon (POX)-inhibited human-RBC-AChE and human-plasma-BChE in comparison to reported reactivator, pralidoxime (2-PAM). DIETHYL OXALATE 85-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 31276662-3 2019 Present study evaluates reactivation potency of two newly developed oximes, K456 and K733, against paraoxon (POX)-inhibited human-RBC-AChE and human-plasma-BChE in comparison to reported reactivator, pralidoxime (2-PAM). Paraoxon 99-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 31276662-3 2019 Present study evaluates reactivation potency of two newly developed oximes, K456 and K733, against paraoxon (POX)-inhibited human-RBC-AChE and human-plasma-BChE in comparison to reported reactivator, pralidoxime (2-PAM). Paraoxon 109-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 31276662-4 2019 In vitro studies showed higher intrinsic toxicities of both oximes than 2-PAM for AChE. Oximes 60-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 31151057-3 2019 A total of 19 dipropargyl substituted diphenylpyrimidines have been synthesized and evaluated for the monoamine oxidase (MAO) and acetylcholinesterase (AChE) inhibition potential. dipropargyl substituted diphenylpyrimidines 14-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 31151057-3 2019 A total of 19 dipropargyl substituted diphenylpyrimidines have been synthesized and evaluated for the monoamine oxidase (MAO) and acetylcholinesterase (AChE) inhibition potential. dipropargyl substituted diphenylpyrimidines 14-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 31158743-0 2019 Caffeic acid phenethyl ester (CAPE)-derivatives act as selective inhibitors of acetylcholinesterase. caffeic acid phenethyl ester 0-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 31158743-0 2019 Caffeic acid phenethyl ester (CAPE)-derivatives act as selective inhibitors of acetylcholinesterase. caffeic acid phenethyl ester 30-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 31158754-2 2019 Herein, synthesis and AChE/BChE inhibition activity of some twenty derivatives of 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole (HHAI) is reported. 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole 82-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 31165654-5 2019 Expert opinion: The available therapeutic arsenal for AD, designed under the traditional paradigm of "one-drug/one target/one-disease", is based on the inhibition of brain acetylcholinesterase (AChE) to increase acetylcholine (ACh) levels. Acetylcholine 172-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 194-198 31165654-5 2019 Expert opinion: The available therapeutic arsenal for AD, designed under the traditional paradigm of "one-drug/one target/one-disease", is based on the inhibition of brain acetylcholinesterase (AChE) to increase acetylcholine (ACh) levels. Acetylcholine 194-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-192 31345366-3 2019 Acetylcholinesterase inhibitors (AChEI) are commonly used as AD treatment to improve cognitive function, but their effect on Zn homeostasis is still unexplored. Zinc 125-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 29656653-0 2019 Derivatization, molecular docking and in vitro acetylcholinesterase inhibitory activity of glycyrrhizin as a selective anti-Alzheimer agent. Glycyrrhizic Acid 91-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 29656653-1 2019 Acetylcholinesterase inhibitors (AChE-Is) increase both level and duration of action of acetylcholine (ACh); thus, alleviate symptoms of Alzheimer"s disease (AD). Acetylcholine 88-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 29656653-1 2019 Acetylcholinesterase inhibitors (AChE-Is) increase both level and duration of action of acetylcholine (ACh); thus, alleviate symptoms of Alzheimer"s disease (AD). Acetylcholine 88-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 29656653-1 2019 Acetylcholinesterase inhibitors (AChE-Is) increase both level and duration of action of acetylcholine (ACh); thus, alleviate symptoms of Alzheimer"s disease (AD). Acetylcholine 33-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 29656653-4 2019 This study reports the synthesis and screening of a series of glycyrrhetinic acid analogs as AChE-Is. Glycyrrhetinic Acid 62-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 31132435-3 2019 Crystal structure of the complex between human AChE and C-35 revealed tight contacts of ligand along the enzyme active site gorge. Carbon 0-1 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 31132435-5 2019 Thus, C-35 is a dual binding site inhibitor of AChE. c-35 6-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 31136966-1 2019 Chlorpyrifos (CPF) is an organophosphate pesticide widely used in agriculture, whose traditional and well-known mechanism of action is the inhibition of the enzyme Acetylcholinesterase (AChE). Chlorpyrifos 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 31136966-1 2019 Chlorpyrifos (CPF) is an organophosphate pesticide widely used in agriculture, whose traditional and well-known mechanism of action is the inhibition of the enzyme Acetylcholinesterase (AChE). Chlorpyrifos 14-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-184 31136966-1 2019 Chlorpyrifos (CPF) is an organophosphate pesticide widely used in agriculture, whose traditional and well-known mechanism of action is the inhibition of the enzyme Acetylcholinesterase (AChE). Chlorpyrifos 14-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 31136966-1 2019 Chlorpyrifos (CPF) is an organophosphate pesticide widely used in agriculture, whose traditional and well-known mechanism of action is the inhibition of the enzyme Acetylcholinesterase (AChE). Organophosphates 25-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-184 31136966-1 2019 Chlorpyrifos (CPF) is an organophosphate pesticide widely used in agriculture, whose traditional and well-known mechanism of action is the inhibition of the enzyme Acetylcholinesterase (AChE). Organophosphates 25-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 31813875-3 2019 Series of new compounds were designed, synthesized and evaluated in this work, from which we identified 2-((4-(1,3-dioxoisoindolin-2-yl)benzyl)amino)-2-oxoethyl-2-(4-methoxyphenyl)acetate (1h) as a new dual cholinesterase and beta-secretase inhibitor without toxicity. 2-((4-(1,3-dioxoisoindolin-2-yl)benzyl)amino)-2-oxoethyl-2-(4-methoxyphenyl)acetate 104-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-221 31385137-5 2019 The thiopental and midazolam showed inhibition effect on AChE in vitro, whereas they showed activation effect in vivo when they are combined together. Thiopental 4-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 31385137-5 2019 The thiopental and midazolam showed inhibition effect on AChE in vitro, whereas they showed activation effect in vivo when they are combined together. Midazolam 19-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 31247192-5 2019 For AChE, two visible substrates were used, acetylthiocholine and 3-(acetamido)-N,N,N-trimethylanilinium. Acetylthiocholine 44-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 31247192-5 2019 For AChE, two visible substrates were used, acetylthiocholine and 3-(acetamido)-N,N,N-trimethylanilinium. 3-(acetamido)-n,n,n-trimethylanilinium 66-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 31247192-6 2019 For AChE, acetylcholine was competing with visible substrates. Acetylcholine 10-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 31813875-3 2019 Series of new compounds were designed, synthesized and evaluated in this work, from which we identified 2-((4-(1,3-dioxoisoindolin-2-yl)benzyl)amino)-2-oxoethyl-2-(4-methoxyphenyl)acetate (1h) as a new dual cholinesterase and beta-secretase inhibitor without toxicity. Hydrogen 189-191 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-221 31507403-7 2019 Of the four compounds screened, only curcumin (-9.6 kcal/mol) and piperine (-10.5 kcal/mol) showed favorable binding affinities and interactions towards AChE and were hence selected. Curcumin 37-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 31507403-7 2019 Of the four compounds screened, only curcumin (-9.6 kcal/mol) and piperine (-10.5 kcal/mol) showed favorable binding affinities and interactions towards AChE and were hence selected. piperine 66-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 31507403-8 2019 In vitro AChE inhibition demonstrated that combination of curcumin and piperine showed greater AChE inhibition with an IC50 of 62.81 +- 0.01 mug/ml as compared to individual compounds, i.e., IC50 of curcumin at 134.5 +- 0.06 mug/ml and IC50 of piperine at 76.6 +- 0.08 mug/ml. Curcumin 58-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 31507403-8 2019 In vitro AChE inhibition demonstrated that combination of curcumin and piperine showed greater AChE inhibition with an IC50 of 62.81 +- 0.01 mug/ml as compared to individual compounds, i.e., IC50 of curcumin at 134.5 +- 0.06 mug/ml and IC50 of piperine at 76.6 +- 0.08 mug/ml. Curcumin 58-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 31507403-8 2019 In vitro AChE inhibition demonstrated that combination of curcumin and piperine showed greater AChE inhibition with an IC50 of 62.81 +- 0.01 mug/ml as compared to individual compounds, i.e., IC50 of curcumin at 134.5 +- 0.06 mug/ml and IC50 of piperine at 76.6 +- 0.08 mug/ml. piperine 71-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 31507403-8 2019 In vitro AChE inhibition demonstrated that combination of curcumin and piperine showed greater AChE inhibition with an IC50 of 62.81 +- 0.01 mug/ml as compared to individual compounds, i.e., IC50 of curcumin at 134.5 +- 0.06 mug/ml and IC50 of piperine at 76.6 +- 0.08 mug/ml. piperine 71-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 31152735-0 2019 Effects of astrocyte conditioned medium on neuronal AChE expression upon 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. Polychlorinated Dibenzodioxins 73-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 31152735-2 2019 Emerging evidence has shown that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a typical persistent organic pollutant, suppressed neuronal AChE activity via dysregulation of different biosynthesis processes in human and rat neuronal cells. Polychlorinated Dibenzodioxins 33-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 31152735-2 2019 Emerging evidence has shown that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a typical persistent organic pollutant, suppressed neuronal AChE activity via dysregulation of different biosynthesis processes in human and rat neuronal cells. Polychlorinated Dibenzodioxins 70-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 31152735-4 2019 As a known target cell of TCDD, the astrocyte might be involved in TCDD effects on neuronal AChE. Polychlorinated Dibenzodioxins 26-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 31152735-4 2019 As a known target cell of TCDD, the astrocyte might be involved in TCDD effects on neuronal AChE. Polychlorinated Dibenzodioxins 67-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 31152735-6 2019 The enzymatic activity of AChE was generally decreased in cultured cortical neurons upon direct treatment with TCDD (0.003-0.01 nM). Polychlorinated Dibenzodioxins 111-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 31152735-8 2019 Compared with effects of treatment with ACM plus TCDD (ACMT), a significant differential effect on AChE activity was found in the TACM group in response to TCDD treatment specifically in immature neurons, suggesting the presence of a TCDD-specific active component derived from the astrocyte. Polychlorinated Dibenzodioxins 156-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 31152735-10 2019 These data indicate that the astrocyte might play a protective role in TCDD-induced alterations of neuronal AChE in certain stages of differentiation. Polychlorinated Dibenzodioxins 71-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 31163137-0 2019 Synthesis and in vitro evaluation of neutral aryloximes as reactivators of Electrophorus eel acetylcholinesterase inhibited by NEMP, a VX surrogate. aryloximes 45-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 31163137-0 2019 Synthesis and in vitro evaluation of neutral aryloximes as reactivators of Electrophorus eel acetylcholinesterase inhibited by NEMP, a VX surrogate. nemp 127-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 31163137-5 2019 In searching for structural factors that may be explored in SAR studies, we synthesized and evaluated neutral aryloximes as reactivators for acetylcholinesterase inhibited by NEMP, a VX surrogate. aryloximes 110-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 31163137-5 2019 In searching for structural factors that may be explored in SAR studies, we synthesized and evaluated neutral aryloximes as reactivators for acetylcholinesterase inhibited by NEMP, a VX surrogate. nemp 175-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 31176713-5 2019 We co-crystallized hAChE in P31 unit cell with the reversible inhibitor 9-aminoacridine that binds at the base of the active center gorge in addition to inhibitors that span the full length of the gorge, donepezil (Aricept, E2020) and AChE specific inhibitor BW284c51. Aminacrine 72-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-24 31154274-3 2019 PURPOSE: The purpose of this study was to investigate the potential competition inhibition of HAR and HAL on MAO and AChE in brain endothelial cells (RBE4) and in healthy rats to provide a basis for the application of the inhibitors in the treatment of patients with depression and with Parkinson"s disease or Alzheimer"s disease. Harmaline 102-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 31228470-1 2019 Acetylcholinesterase (AChE) is an enzyme which terminates the cholinergic neurotransmission, by hydrolyzing acetylcholine at the nerve and nerve-muscle junctions. Acetylcholine 108-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 31228470-1 2019 Acetylcholinesterase (AChE) is an enzyme which terminates the cholinergic neurotransmission, by hydrolyzing acetylcholine at the nerve and nerve-muscle junctions. Acetylcholine 108-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 31228470-3 2019 Based on our derived 3D-QSAR model for the reversible AChE inhibitors, we designed and synthesized three novel compounds 8-10, joining the tacrine and aroylacrylic acid phenylamide moieties, with a longer methylene chain to target two distinct, toplogically separated anionic areas on the AChE. Tacrine 139-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 31228470-6 2019 Putative noncovalent interactions of the selected ligand 10 with AChE active site gorge were finally explored by molecular dynamics simulation suggesting a formation of the salt bridge between the protonated linker amino group and the negatively charged Asp74 carboxylate side chain as a significant player for the successful molecular recognition in line with the design strategy. asp74 carboxylate 254-271 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 31257860-7 2019 The study also attempted to explore the mechanistic aspect of improved efficacy through biochemical evaluation (AChE histo-enzymology), which reveals that levels of dopamine and its metabolite 3,4-dihydroxyphenylacetic acid were unaffected, but AChE activity was improved for all forms of RIV. Dopamine 165-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 31257860-7 2019 The study also attempted to explore the mechanistic aspect of improved efficacy through biochemical evaluation (AChE histo-enzymology), which reveals that levels of dopamine and its metabolite 3,4-dihydroxyphenylacetic acid were unaffected, but AChE activity was improved for all forms of RIV. Dopamine 165-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 245-249 31281020-2 2019 Compound 10j, which is tacrine linked with pyrazolo[3,4-b]pyridine moiety by a six-carbon spacer, was the most potent acetylcholinesterase (AChE) with IC50 value of 0.125 muM. Tacrine 23-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 31281020-2 2019 Compound 10j, which is tacrine linked with pyrazolo[3,4-b]pyridine moiety by a six-carbon spacer, was the most potent acetylcholinesterase (AChE) with IC50 value of 0.125 muM. Tacrine 23-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 31281020-2 2019 Compound 10j, which is tacrine linked with pyrazolo[3,4-b]pyridine moiety by a six-carbon spacer, was the most potent acetylcholinesterase (AChE) with IC50 value of 0.125 muM. pyrazolo(3,4-b)pyridine 43-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 31281020-2 2019 Compound 10j, which is tacrine linked with pyrazolo[3,4-b]pyridine moiety by a six-carbon spacer, was the most potent acetylcholinesterase (AChE) with IC50 value of 0.125 muM. pyrazolo(3,4-b)pyridine 43-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 31281020-2 2019 Compound 10j, which is tacrine linked with pyrazolo[3,4-b]pyridine moiety by a six-carbon spacer, was the most potent acetylcholinesterase (AChE) with IC50 value of 0.125 muM. Carbon 83-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 31176713-5 2019 We co-crystallized hAChE in P31 unit cell with the reversible inhibitor 9-aminoacridine that binds at the base of the active center gorge in addition to inhibitors that span the full length of the gorge, donepezil (Aricept, E2020) and AChE specific inhibitor BW284c51. Aminacrine 72-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 31176713-5 2019 We co-crystallized hAChE in P31 unit cell with the reversible inhibitor 9-aminoacridine that binds at the base of the active center gorge in addition to inhibitors that span the full length of the gorge, donepezil (Aricept, E2020) and AChE specific inhibitor BW284c51. Donepezil 204-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-24 31176713-5 2019 We co-crystallized hAChE in P31 unit cell with the reversible inhibitor 9-aminoacridine that binds at the base of the active center gorge in addition to inhibitors that span the full length of the gorge, donepezil (Aricept, E2020) and AChE specific inhibitor BW284c51. Donepezil 204-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 31176713-5 2019 We co-crystallized hAChE in P31 unit cell with the reversible inhibitor 9-aminoacridine that binds at the base of the active center gorge in addition to inhibitors that span the full length of the gorge, donepezil (Aricept, E2020) and AChE specific inhibitor BW284c51. Donepezil 215-222 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-24 31176713-5 2019 We co-crystallized hAChE in P31 unit cell with the reversible inhibitor 9-aminoacridine that binds at the base of the active center gorge in addition to inhibitors that span the full length of the gorge, donepezil (Aricept, E2020) and AChE specific inhibitor BW284c51. Donepezil 215-222 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 31176713-5 2019 We co-crystallized hAChE in P31 unit cell with the reversible inhibitor 9-aminoacridine that binds at the base of the active center gorge in addition to inhibitors that span the full length of the gorge, donepezil (Aricept, E2020) and AChE specific inhibitor BW284c51. Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide 259-267 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-24 31176713-5 2019 We co-crystallized hAChE in P31 unit cell with the reversible inhibitor 9-aminoacridine that binds at the base of the active center gorge in addition to inhibitors that span the full length of the gorge, donepezil (Aricept, E2020) and AChE specific inhibitor BW284c51. Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide 259-267 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 31176713-7 2019 Successful solution of the new room temperature 3.2 A resolution structure of BW284c51*hAChE complex from large P31 crystals enables us to proceed with studying room temperature structures of lower affinity complexes, such as oxime reactivators bound to hAChE, where temperature-related conformational diversity could be expected in both oxime and hAChE, which could lead to better informed structure-based design under conditions approaching physiological temperature. Oximes 226-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-92 31176713-7 2019 Successful solution of the new room temperature 3.2 A resolution structure of BW284c51*hAChE complex from large P31 crystals enables us to proceed with studying room temperature structures of lower affinity complexes, such as oxime reactivators bound to hAChE, where temperature-related conformational diversity could be expected in both oxime and hAChE, which could lead to better informed structure-based design under conditions approaching physiological temperature. Oximes 338-343 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-92 31360962-0 2019 Molecular recognition of organophosphorus compounds in water and inhibition of their toxicity to acetylcholinesterase. organophosphorus 25-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 31360962-0 2019 Molecular recognition of organophosphorus compounds in water and inhibition of their toxicity to acetylcholinesterase. Water 55-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 31360962-2 2019 They can also be used as a fluorescent sensor for nerve agent simulants and as an inhibitor to reduce the toxicity of paraoxon to acetylcholinesterase. Paraoxon 118-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 31405089-8 2019 Cd alone significantly decreased the post-exposure predatory performance (PEPP) of M-est (>=6 mg/L) and L-est juveniles (>=3 mg/L), and acetylcholinesterase (AChE) activity of M-est juveniles (13 mg/L). Cadmium 0-2 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 31405089-9 2019 MPs alone (0.14 mg/L) significantly reduced the PEPP and AChE activity of L-est juveniles but not of M-est juveniles. mps 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 31405089-10 2019 MPs-Cd mixtures (3-13 mg/L of Cd + 0.14 mg/L of MPs) significantly inhibited the PEPP of juveniles from both estuaries and AChE of L-est estuary juveniles but not of M-est juveniles. mps-cd 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 31405089-10 2019 MPs-Cd mixtures (3-13 mg/L of Cd + 0.14 mg/L of MPs) significantly inhibited the PEPP of juveniles from both estuaries and AChE of L-est estuary juveniles but not of M-est juveniles. Cadmium 4-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 31405089-10 2019 MPs-Cd mixtures (3-13 mg/L of Cd + 0.14 mg/L of MPs) significantly inhibited the PEPP of juveniles from both estuaries and AChE of L-est estuary juveniles but not of M-est juveniles. mps 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 31353389-1 2019 Acetylcholinesterase (AChE) plays a vital role in nerve conduction through rapidly hydrolyzing the neurotransmitter acetylcholine (ACh) and is correlated with Alzheimer"s disease. Acetylcholine 116-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 31353389-1 2019 Acetylcholinesterase (AChE) plays a vital role in nerve conduction through rapidly hydrolyzing the neurotransmitter acetylcholine (ACh) and is correlated with Alzheimer"s disease. Acetylcholine 116-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 31353389-1 2019 Acetylcholinesterase (AChE) plays a vital role in nerve conduction through rapidly hydrolyzing the neurotransmitter acetylcholine (ACh) and is correlated with Alzheimer"s disease. Acetylcholine 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 31353389-5 2019 In the presence of acetylcholinesterase (AChE), acetylthiocholine (ATCh) could be hydrolyzed to thiocholine (TCh), which can reduce MnO2 to Mn2+ and trigger the decomposition of MnO2 nanosheets. Acetylthiocholine 48-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 31353389-5 2019 In the presence of acetylcholinesterase (AChE), acetylthiocholine (ATCh) could be hydrolyzed to thiocholine (TCh), which can reduce MnO2 to Mn2+ and trigger the decomposition of MnO2 nanosheets. Acetylthiocholine 48-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 31353389-5 2019 In the presence of acetylcholinesterase (AChE), acetylthiocholine (ATCh) could be hydrolyzed to thiocholine (TCh), which can reduce MnO2 to Mn2+ and trigger the decomposition of MnO2 nanosheets. Acetylthiocholine 67-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 31353389-5 2019 In the presence of acetylcholinesterase (AChE), acetylthiocholine (ATCh) could be hydrolyzed to thiocholine (TCh), which can reduce MnO2 to Mn2+ and trigger the decomposition of MnO2 nanosheets. Acetylthiocholine 67-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 31353389-5 2019 In the presence of acetylcholinesterase (AChE), acetylthiocholine (ATCh) could be hydrolyzed to thiocholine (TCh), which can reduce MnO2 to Mn2+ and trigger the decomposition of MnO2 nanosheets. Thiocholine 54-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 31353389-5 2019 In the presence of acetylcholinesterase (AChE), acetylthiocholine (ATCh) could be hydrolyzed to thiocholine (TCh), which can reduce MnO2 to Mn2+ and trigger the decomposition of MnO2 nanosheets. Thiocholine 54-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 31353389-5 2019 In the presence of acetylcholinesterase (AChE), acetylthiocholine (ATCh) could be hydrolyzed to thiocholine (TCh), which can reduce MnO2 to Mn2+ and trigger the decomposition of MnO2 nanosheets. Thiocholine 68-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 31353389-5 2019 In the presence of acetylcholinesterase (AChE), acetylthiocholine (ATCh) could be hydrolyzed to thiocholine (TCh), which can reduce MnO2 to Mn2+ and trigger the decomposition of MnO2 nanosheets. Thiocholine 68-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 31353389-5 2019 In the presence of acetylcholinesterase (AChE), acetylthiocholine (ATCh) could be hydrolyzed to thiocholine (TCh), which can reduce MnO2 to Mn2+ and trigger the decomposition of MnO2 nanosheets. manganese dioxide 132-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 31353389-5 2019 In the presence of acetylcholinesterase (AChE), acetylthiocholine (ATCh) could be hydrolyzed to thiocholine (TCh), which can reduce MnO2 to Mn2+ and trigger the decomposition of MnO2 nanosheets. manganese dioxide 132-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 31353389-5 2019 In the presence of acetylcholinesterase (AChE), acetylthiocholine (ATCh) could be hydrolyzed to thiocholine (TCh), which can reduce MnO2 to Mn2+ and trigger the decomposition of MnO2 nanosheets. Manganese(2+) 140-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 31353389-5 2019 In the presence of acetylcholinesterase (AChE), acetylthiocholine (ATCh) could be hydrolyzed to thiocholine (TCh), which can reduce MnO2 to Mn2+ and trigger the decomposition of MnO2 nanosheets. Manganese(2+) 140-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 31353389-5 2019 In the presence of acetylcholinesterase (AChE), acetylthiocholine (ATCh) could be hydrolyzed to thiocholine (TCh), which can reduce MnO2 to Mn2+ and trigger the decomposition of MnO2 nanosheets. manganese dioxide 178-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 31353389-5 2019 In the presence of acetylcholinesterase (AChE), acetylthiocholine (ATCh) could be hydrolyzed to thiocholine (TCh), which can reduce MnO2 to Mn2+ and trigger the decomposition of MnO2 nanosheets. manganese dioxide 178-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 31353389-10 2019 Furthermore, pesticide carbaryl as an inhibitor of AChE activity was detected. Carbaryl 23-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 31598242-4 2019 Moreover, the reaction of Novichok agents with acetylcholinesterase serine was calculated to be most thermodynamically favoured for Novichok candidate A234. cholecystokinin C-terminal flanking peptide 68-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 31129502-0 2019 Synthesis, biological evaluation and in silico studies of novel N-substituted phthalazine sulfonamide compounds as potent carbonic anhydrase and acetylcholinesterase inhibitors. n-substituted phthalazine sulfonamide 64-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 31129502-6 2019 ADME prediction study of the designed N-substituted phthalazine sulfonamides showed that they are not only with carbonic anhydrase and acetylcholinesterase inhibitory activities but also with appropriate pharmacokinetic, physicochemical parameters and drug-likeness properties. n-substituted phthalazine sulfonamides 38-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 31158577-6 2019 Amongst them, 7k, 7m and 7p, all with a 6 carbon linker between tacrine and isatin Schiff base exhibited the strongest inhibitory activity against AChE with IC50 values of 0.42 nM, 0.62 nM and 0.95 nM, respectively. Carbon 42-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 31158577-6 2019 Amongst them, 7k, 7m and 7p, all with a 6 carbon linker between tacrine and isatin Schiff base exhibited the strongest inhibitory activity against AChE with IC50 values of 0.42 nM, 0.62 nM and 0.95 nM, respectively. Tacrine 64-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 31158577-6 2019 Amongst them, 7k, 7m and 7p, all with a 6 carbon linker between tacrine and isatin Schiff base exhibited the strongest inhibitory activity against AChE with IC50 values of 0.42 nM, 0.62 nM and 0.95 nM, respectively. isatin schiff base 76-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 31158577-7 2019 They were 92-, 62- and 41-fold more active than tacrine (IC50 = 38.72 nM) toward AChE. Tacrine 48-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 31176239-0 2019 Design and development of 1,3,4-oxadiazole derivatives as potential inhibitors of acetylcholinesterase to ameliorate scopolamine-induced cognitive dysfunctions. 1,3,4-oxadiazole 26-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 31176239-0 2019 Design and development of 1,3,4-oxadiazole derivatives as potential inhibitors of acetylcholinesterase to ameliorate scopolamine-induced cognitive dysfunctions. Scopolamine 117-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 31061298-0 2019 A Probe for Fluorescence Detection of the Acetylcholinesterase Activity Based on Molecularly Imprinted Polymers Coated Carbon Dots. Polymers 103-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 31288978-0 2019 Design, synthesis, and evaluation of novel N-(4-phenoxybenzyl)aniline derivatives targeting acetylcholinesterase, beta-amyloid aggregation and oxidative stress to treat Alzheimer"s disease. n-(4-phenoxybenzyl)aniline 43-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 31288978-1 2019 Novel hybrids N-(4-phenoxybenzyl)aniline were designed, synthesized, and evaluated for their potential AChE inhibitory activity along with antioxidant potential. n-(4-phenoxybenzyl)aniline 14-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 31288978-5 2019 Meanwhile, compound 42 also inhibited AChE-induced Abeta aggregation (39.5-66.9%) in thioflavin T assay. thioflavin T 85-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 31100281-0 2019 Structural aspects of 4-aminoquinolines as reversible inhibitors of human acetylcholinesterase and butyrylcholinesterase. 4-aminoquinoline 22-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 31100281-1 2019 Eight derivatives of 4-aminoquinolines differing in the substituents attached to the C(4)-amino group and C(7) were synthesised and tested as inhibitors of human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). 4-aminoquinoline 21-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-182 31100281-1 2019 Eight derivatives of 4-aminoquinolines differing in the substituents attached to the C(4)-amino group and C(7) were synthesised and tested as inhibitors of human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). 4-aminoquinoline 21-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-188 31100281-3 2019 The most potent inhibitors of AChE were compounds with an n-octylamino chain or adamantyl group. adamantyl 80-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 31100281-5 2019 Docking studies revealed that the quinoline group within the AChE active site was positioned in the choline binding site, while the C(4)-amino group substituents, depending on their lipophilicity, could establish hydrogen bonds or pi-interactions with residues of the peripheral anionic site. quinoline 34-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 31100281-5 2019 Docking studies revealed that the quinoline group within the AChE active site was positioned in the choline binding site, while the C(4)-amino group substituents, depending on their lipophilicity, could establish hydrogen bonds or pi-interactions with residues of the peripheral anionic site. Choline 100-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 31100281-5 2019 Docking studies revealed that the quinoline group within the AChE active site was positioned in the choline binding site, while the C(4)-amino group substituents, depending on their lipophilicity, could establish hydrogen bonds or pi-interactions with residues of the peripheral anionic site. Hydrogen 213-221 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 31100281-7 2019 Based on AChE inhibition, compounds with an n-octylamino chain or adamantyl substituent were shown to possess the capacity for further development as potential drugs for treatment of neurodegenerative diseases. adamantyl 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 31100277-1 2019 Since the development in the 1950"s of 2-PAM (Pralidoxime), an antidote that reactivates organophosphate conjugated acetylcholinesterase in target tissues upon pesticide or nerve agent exposure, improvements in antidotal therapy have largely involved congeneric pyridinium aldoximes. pralidoxime 39-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 31100277-1 2019 Since the development in the 1950"s of 2-PAM (Pralidoxime), an antidote that reactivates organophosphate conjugated acetylcholinesterase in target tissues upon pesticide or nerve agent exposure, improvements in antidotal therapy have largely involved congeneric pyridinium aldoximes. pralidoxime 46-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 31100277-1 2019 Since the development in the 1950"s of 2-PAM (Pralidoxime), an antidote that reactivates organophosphate conjugated acetylcholinesterase in target tissues upon pesticide or nerve agent exposure, improvements in antidotal therapy have largely involved congeneric pyridinium aldoximes. Organophosphates 89-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 31129131-3 2019 Acetylecholine (ACh), a cholinergic neurotransmitter hydrolyzed by acetylcholinesterase (AChE), is an essential neurotransmitter and neuromodulator in central and peripheral nervous system and has regulatory influence on numerous neuronal functions including addiction. acetylecholine 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 31129131-3 2019 Acetylecholine (ACh), a cholinergic neurotransmitter hydrolyzed by acetylcholinesterase (AChE), is an essential neurotransmitter and neuromodulator in central and peripheral nervous system and has regulatory influence on numerous neuronal functions including addiction. acetylecholine 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 31129131-3 2019 Acetylecholine (ACh), a cholinergic neurotransmitter hydrolyzed by acetylcholinesterase (AChE), is an essential neurotransmitter and neuromodulator in central and peripheral nervous system and has regulatory influence on numerous neuronal functions including addiction. Acetylcholine 16-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 31129131-3 2019 Acetylecholine (ACh), a cholinergic neurotransmitter hydrolyzed by acetylcholinesterase (AChE), is an essential neurotransmitter and neuromodulator in central and peripheral nervous system and has regulatory influence on numerous neuronal functions including addiction. Acetylcholine 16-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 31175846-1 2019 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 31175846-1 2019 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 31175846-1 2019 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Esters 15-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 31175846-1 2019 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Esters 15-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 31175846-1 2019 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates 37-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 31175846-1 2019 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates 37-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 31175846-1 2019 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Serine 147-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 31175846-1 2019 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Serine 147-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 31175846-1 2019 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates 215-224 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 31175846-1 2019 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates 215-224 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 31175846-3 2019 Therefore, carbamates are effective AChE inhibitors that have been developed as insecticides and as therapeutic agents. Carbamates 11-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 31175846-5 2019 We also review data showing that solvent deuterium oxide isotope effects for decarbamoylation decreased from 2.8 for N-monomethylcarbamoyl AChE to 1.1 for N,N-diethylcarbamoyl AChE, indicating a shift in the rate-limiting step from general acid-base catalysis to a likely conformational change in the distorted active site in N,N-diethylcarbamoyl AChE. Deuterium Oxide 41-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 31175846-5 2019 We also review data showing that solvent deuterium oxide isotope effects for decarbamoylation decreased from 2.8 for N-monomethylcarbamoyl AChE to 1.1 for N,N-diethylcarbamoyl AChE, indicating a shift in the rate-limiting step from general acid-base catalysis to a likely conformational change in the distorted active site in N,N-diethylcarbamoyl AChE. Deuterium Oxide 41-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 31175846-5 2019 We also review data showing that solvent deuterium oxide isotope effects for decarbamoylation decreased from 2.8 for N-monomethylcarbamoyl AChE to 1.1 for N,N-diethylcarbamoyl AChE, indicating a shift in the rate-limiting step from general acid-base catalysis to a likely conformational change in the distorted active site in N,N-diethylcarbamoyl AChE. Deuterium Oxide 41-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 31175846-5 2019 We also review data showing that solvent deuterium oxide isotope effects for decarbamoylation decreased from 2.8 for N-monomethylcarbamoyl AChE to 1.1 for N,N-diethylcarbamoyl AChE, indicating a shift in the rate-limiting step from general acid-base catalysis to a likely conformational change in the distorted active site in N,N-diethylcarbamoyl AChE. Nitrogen 117-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 31175846-5 2019 We also review data showing that solvent deuterium oxide isotope effects for decarbamoylation decreased from 2.8 for N-monomethylcarbamoyl AChE to 1.1 for N,N-diethylcarbamoyl AChE, indicating a shift in the rate-limiting step from general acid-base catalysis to a likely conformational change in the distorted active site in N,N-diethylcarbamoyl AChE. Nitrogen 117-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 31175846-5 2019 We also review data showing that solvent deuterium oxide isotope effects for decarbamoylation decreased from 2.8 for N-monomethylcarbamoyl AChE to 1.1 for N,N-diethylcarbamoyl AChE, indicating a shift in the rate-limiting step from general acid-base catalysis to a likely conformational change in the distorted active site in N,N-diethylcarbamoyl AChE. Nitrogen 117-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 31207061-6 2019 For CA I and CA II, the best inhibition enzymes, was the Ni(II) complex with 62.98+-18.41, 86.17+-23.62 Ki values, whereas this inhibition effect showed ligand with 24.53+-2.66 Ki value for the AChE enzyme. Nickel(2+) 57-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 194-198 31061298-0 2019 A Probe for Fluorescence Detection of the Acetylcholinesterase Activity Based on Molecularly Imprinted Polymers Coated Carbon Dots. Carbon 119-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 31061298-1 2019 This paper presents a new probe for fluorescence detection of the acetylcholinesterase (AChE) activity based on molecularly imprinted polymer (MIP) coated carbon dots (C-dots) composite. Polymers 134-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 31061298-1 2019 This paper presents a new probe for fluorescence detection of the acetylcholinesterase (AChE) activity based on molecularly imprinted polymer (MIP) coated carbon dots (C-dots) composite. Polymers 134-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 31061298-1 2019 This paper presents a new probe for fluorescence detection of the acetylcholinesterase (AChE) activity based on molecularly imprinted polymer (MIP) coated carbon dots (C-dots) composite. Carbon 155-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 31061298-1 2019 This paper presents a new probe for fluorescence detection of the acetylcholinesterase (AChE) activity based on molecularly imprinted polymer (MIP) coated carbon dots (C-dots) composite. Carbon 155-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 31061298-4 2019 With AChE, its substrate ACh will be hydrolyzed into thiocholine and the fluorescence signals exhibit a dramatic decrease at 465 nm, Under optimal conditions, the fluorescent probe shows sensitive responses to AChE in the range of 0.01-0.6 mU/mL. Acetylthiocholine 5-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-214 31061298-4 2019 With AChE, its substrate ACh will be hydrolyzed into thiocholine and the fluorescence signals exhibit a dramatic decrease at 465 nm, Under optimal conditions, the fluorescent probe shows sensitive responses to AChE in the range of 0.01-0.6 mU/mL. Thiocholine 53-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 31061298-4 2019 With AChE, its substrate ACh will be hydrolyzed into thiocholine and the fluorescence signals exhibit a dramatic decrease at 465 nm, Under optimal conditions, the fluorescent probe shows sensitive responses to AChE in the range of 0.01-0.6 mU/mL. Thiocholine 53-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-214 31517530-2 2019 The structural properties and binding interactions of the AD drug physostigmine (-)-phy, and its analogues (-)-hex and (-)-phe and (+)-phe, were examined, as well as their impact on the conformational changes of two different AD target enzymes AChE and BChE. Physostigmine 66-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 244-248 31222828-9 2019 In particular, compound IX, having better activity than galantamine against acetylcholinesterase and butyrylcholinesterase enzymes, was visualized using molecular docking. Galantamine 56-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 30088792-0 2019 In vitro and in silico evaluation of fucosterol from Sargassum horridum as potential human acetylcholinesterase inhibitor. fucosterol 37-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 30088792-2 2019 In this study, the activity in vitro of the fucosterol from Sargassum horridum as potential human acetylcholinesterase inhibitor was evaluated. fucosterol 44-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-118 30088792-3 2019 The structural identification was obtained by nuclear magnetic resonance (NMR) spectroscopy and based on experimental data, we combined docking and molecular dynamics simulations coupled to the molecular-mechanics-generalized-born-surface-area approach to evaluating the structural and energetic basis for the molecular recognition of fucosterol and neostigmine at the binding site of acetylcholinesterase (AChE). fucosterol 335-345 acetylcholinesterase (Cartwright blood group) Homo sapiens 385-405 30088792-3 2019 The structural identification was obtained by nuclear magnetic resonance (NMR) spectroscopy and based on experimental data, we combined docking and molecular dynamics simulations coupled to the molecular-mechanics-generalized-born-surface-area approach to evaluating the structural and energetic basis for the molecular recognition of fucosterol and neostigmine at the binding site of acetylcholinesterase (AChE). fucosterol 335-345 acetylcholinesterase (Cartwright blood group) Homo sapiens 407-411 30088792-7 2019 Structural analysis revealed that neostigmine reaches the AChE binding site reported elsewhere, whereas fucosterol can act as a no-competitive and competitive acetylcholinesterase inhibitor, in agree with kinetic enzymatic experiments. Neostigmine 34-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 30088792-7 2019 Structural analysis revealed that neostigmine reaches the AChE binding site reported elsewhere, whereas fucosterol can act as a no-competitive and competitive acetylcholinesterase inhibitor, in agree with kinetic enzymatic experiments. fucosterol 104-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 30088792-8 2019 Binding free energy calculations revealed that fucosterol reaches the acetylcholinesterase binding site with higher affinity than neostigmine, which is according to experimental results. fucosterol 47-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 30088792-8 2019 Binding free energy calculations revealed that fucosterol reaches the acetylcholinesterase binding site with higher affinity than neostigmine, which is according to experimental results. Neostigmine 130-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 30088792-10 2019 Results corroborate the ability of theoretical methods to provide crucial information at the atomic level about energetic and structural differences in the binding interaction and affinity from fucosterol with AChE. fucosterol 194-204 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-214 31098925-2 2019 Pyridostigmine is an acetylcholinesterase inhibitor which has been used to augment autonomic signaling. Pyridostigmine Bromide 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 30515633-1 2019 In the present study, 14 novel naphthyridine-11-amine derivatives were synthesized and their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were evaluated. naphthyridine-11-amine 31-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 30515633-1 2019 In the present study, 14 novel naphthyridine-11-amine derivatives were synthesized and their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were evaluated. naphthyridine-11-amine 31-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 31055149-1 2019 2-(piperazin-1-yl)N-(1H-pyrazolo[3,4-b]pyridin-3-yl)acetamides are described as a new class of selective and potent acetylcholinesterase (AChE) inhibitors and amyloid beta aggregation inhibitors. 2-(piperazin-1-yl)n-(1h-pyrazolo[3,4-b]pyridin-3-yl)acetamides 0-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 31517530-4 2019 Results & conclusions: The binding free energy (DeltaGbind) and the change in the free energy surface (FES) computed from the funnel metadynamics (FMD) simulation, both support the idea that inhibitors (-)-phe and (-)-hex have better binding activities toward enzyme AChE, and that (-)-phe is stronger in binding than the present AD drug (-)-phy. Phenylalanine 206-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 267-271 31363918-0 2019 Carbon dots co-doped with nitrogen and chlorine for "off-on" fluorometric determination of the activity of acetylcholinesterase and for quantification of organophosphate pesticides. Carbon 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 31370232-5 2019 Indeed, inhibiting central AChE with brain-penetrating designed carbamates which are able to covalently bind to the enzyme and to concomitantly liberate active metabolites in the brain could constitute a clinically more efficient approach which, additionally, is less likely to cause peripheral side effects. Carbamates 64-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 31363918-0 2019 Carbon dots co-doped with nitrogen and chlorine for "off-on" fluorometric determination of the activity of acetylcholinesterase and for quantification of organophosphate pesticides. Nitrogen 26-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 31363918-0 2019 Carbon dots co-doped with nitrogen and chlorine for "off-on" fluorometric determination of the activity of acetylcholinesterase and for quantification of organophosphate pesticides. Chlorine 39-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 31363918-3 2019 The N,Cl-CDs were employed to detect acetylcholinesterase (AChE) activity and organophosphate pesticides (OPs) which are enzyme inhibitors. n,cl-cds 4-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 31177620-3 2019 N-[2-Oxo-1-(prop-2-ynyl)indolin-3-ylidene]benzo[d][1,3]dioxole-5-carbohydrazide (3) was identified as a lead AChE inhibitor with IC50 =0.052+-0.006 mum. n-[2-oxo-1-(prop-2-ynyl)indolin-3-ylidene]benzo[d][1,3]dioxole-5-carbohydrazide 0-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 31363918-3 2019 The N,Cl-CDs were employed to detect acetylcholinesterase (AChE) activity and organophosphate pesticides (OPs) which are enzyme inhibitors. n,cl-cds 4-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 31363918-4 2019 Acetylthiocholine is enzymatically split by AChE to produce thiocholine which triggers the decomposition of Ellmans"s reagent to form a yellow colored product (2-nitro-5-thiobenzoate anion). Acetylthiocholine 0-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 31363918-4 2019 Acetylthiocholine is enzymatically split by AChE to produce thiocholine which triggers the decomposition of Ellmans"s reagent to form a yellow colored product (2-nitro-5-thiobenzoate anion). Thiocholine 6-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 31363918-4 2019 Acetylthiocholine is enzymatically split by AChE to produce thiocholine which triggers the decomposition of Ellmans"s reagent to form a yellow colored product (2-nitro-5-thiobenzoate anion). 2-nitro-5-thiobenzoate anion 160-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 31363918-7 2019 If organophosphates are present, the activity of AChE becomes increasingly blocked, and this leads to a less expressed IFE and an increasing recovery of fluorescence. Organophosphates 3-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 31319560-11 2019 In the in vitro investigations, 3,4-di-o-caffeoylquinic acid (5281780), apigenin (5280443), and 7-o-methylwogonin (188316) were found to be strong inhibitors of AChE, BChE, and BACE-1. 3,4-di-O-caffeoylquinic acid 32-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-165 31319560-11 2019 In the in vitro investigations, 3,4-di-o-caffeoylquinic acid (5281780), apigenin (5280443), and 7-o-methylwogonin (188316) were found to be strong inhibitors of AChE, BChE, and BACE-1. Moslosooflavone 96-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-165 31176571-11 2019 Results suggest that triazolopyrimidines are potential candidate for Acetylcholinesterase (AChE), Butyrylcholinesterase (BuChE), and amyloid beta aggregation inhibition. triazolopyrimidines 21-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 31029943-0 2019 Benzoic acid-derived nitrones: A new class of potential acetylcholinesterase inhibitors and neuroprotective agents. Benzoic Acid 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 31029943-0 2019 Benzoic acid-derived nitrones: A new class of potential acetylcholinesterase inhibitors and neuroprotective agents. nitrones 21-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 31029943-4 2019 In general, tert-butyl derivatives effectively inhibited AChE, being compound 33 the most potent (IC50 = 8.3 +- 0.3 muM; Ki 5.2 muM). tert-butyl 12-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 31281951-7 2019 Prucalopride, a high-affinity 5HT4 agonist, and pyridostigmine, an acetylcholinesterase inhibitor, may help improve colonic transit in patients with constipation. Pyridostigmine Bromide 48-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 31173012-1 2019 Donepezil, an acetylcholinesterase inhibitor, is an approved drug for the symptomatic treatment of Alzheimer"s disease (AD). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 31173012-2 2019 The mechanistic pathway for the inhibition mechanism of acetylcholinesterase (AChE) by donepezil is not well explored. Donepezil 87-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 31173012-2 2019 The mechanistic pathway for the inhibition mechanism of acetylcholinesterase (AChE) by donepezil is not well explored. Donepezil 87-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 31173012-3 2019 We report for the first time, the inhibition mechanism of AChE by the donepezil drug molecule for the hydrolysis of acetylcholine (ACh) with docking and well-tempered metadynamics (WTMtD) simulations with a human acetylcholinesterase (hAChE) crystal structure (). Donepezil 70-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 31173012-3 2019 We report for the first time, the inhibition mechanism of AChE by the donepezil drug molecule for the hydrolysis of acetylcholine (ACh) with docking and well-tempered metadynamics (WTMtD) simulations with a human acetylcholinesterase (hAChE) crystal structure (). Donepezil 70-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-233 31173012-3 2019 We report for the first time, the inhibition mechanism of AChE by the donepezil drug molecule for the hydrolysis of acetylcholine (ACh) with docking and well-tempered metadynamics (WTMtD) simulations with a human acetylcholinesterase (hAChE) crystal structure (). Donepezil 70-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 235-240 31173012-3 2019 We report for the first time, the inhibition mechanism of AChE by the donepezil drug molecule for the hydrolysis of acetylcholine (ACh) with docking and well-tempered metadynamics (WTMtD) simulations with a human acetylcholinesterase (hAChE) crystal structure (). Acetylcholine 116-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 31173012-3 2019 We report for the first time, the inhibition mechanism of AChE by the donepezil drug molecule for the hydrolysis of acetylcholine (ACh) with docking and well-tempered metadynamics (WTMtD) simulations with a human acetylcholinesterase (hAChE) crystal structure (). Acetylcholine 116-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-233 31173012-3 2019 We report for the first time, the inhibition mechanism of AChE by the donepezil drug molecule for the hydrolysis of acetylcholine (ACh) with docking and well-tempered metadynamics (WTMtD) simulations with a human acetylcholinesterase (hAChE) crystal structure (). Acetylcholine 116-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 235-240 31173012-3 2019 We report for the first time, the inhibition mechanism of AChE by the donepezil drug molecule for the hydrolysis of acetylcholine (ACh) with docking and well-tempered metadynamics (WTMtD) simulations with a human acetylcholinesterase (hAChE) crystal structure (). Acetylcholine 58-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-233 31173012-3 2019 We report for the first time, the inhibition mechanism of AChE by the donepezil drug molecule for the hydrolysis of acetylcholine (ACh) with docking and well-tempered metadynamics (WTMtD) simulations with a human acetylcholinesterase (hAChE) crystal structure (). Acetylcholine 58-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 235-240 31173012-4 2019 This study explored the orientation of the donepezil drug molecule inside the gorge of AChE. Donepezil 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 31173012-5 2019 The 1D free energy surface obtained from WTMtD simulation studies reveals that the orientation of donepezil in the crystal donepezil (-87.25 kJ mol-1) is energetically more favored than the other orientation of donepezil (-74.74 kJ mol-1) for inhibition of AChE. Donepezil 98-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 257-261 31173012-5 2019 The 1D free energy surface obtained from WTMtD simulation studies reveals that the orientation of donepezil in the crystal donepezil (-87.25 kJ mol-1) is energetically more favored than the other orientation of donepezil (-74.74 kJ mol-1) for inhibition of AChE. Donepezil 123-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 257-261 31173012-5 2019 The 1D free energy surface obtained from WTMtD simulation studies reveals that the orientation of donepezil in the crystal donepezil (-87.25 kJ mol-1) is energetically more favored than the other orientation of donepezil (-74.74 kJ mol-1) for inhibition of AChE. Donepezil 123-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 257-261 31173012-7 2019 The WTMtD simulation performed with the crystal structure of donepezil bound hAChE gives the conformation of donepezil at Basin-I as similar to the conformation of donepezil observed in the crystal structure (). Donepezil 61-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-82 31173012-7 2019 The WTMtD simulation performed with the crystal structure of donepezil bound hAChE gives the conformation of donepezil at Basin-I as similar to the conformation of donepezil observed in the crystal structure (). Donepezil 109-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-82 31173012-7 2019 The WTMtD simulation performed with the crystal structure of donepezil bound hAChE gives the conformation of donepezil at Basin-I as similar to the conformation of donepezil observed in the crystal structure (). Donepezil 109-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-82 31173012-8 2019 The WTMtD simulations further reveal that the bridged water molecules are more ordered near the catalytic triad of AChE to deter the nucleophilicity of Ser203 through intermolecular hydrogen bonding when donepezil approaches near to the active site gorge of AChE. Water 54-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 31173012-8 2019 The WTMtD simulations further reveal that the bridged water molecules are more ordered near the catalytic triad of AChE to deter the nucleophilicity of Ser203 through intermolecular hydrogen bonding when donepezil approaches near to the active site gorge of AChE. Water 54-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 258-262 31173012-8 2019 The WTMtD simulations further reveal that the bridged water molecules are more ordered near the catalytic triad of AChE to deter the nucleophilicity of Ser203 through intermolecular hydrogen bonding when donepezil approaches near to the active site gorge of AChE. Hydrogen 182-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 31173012-8 2019 The WTMtD simulations further reveal that the bridged water molecules are more ordered near the catalytic triad of AChE to deter the nucleophilicity of Ser203 through intermolecular hydrogen bonding when donepezil approaches near to the active site gorge of AChE. Hydrogen 182-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 258-262 31173012-8 2019 The WTMtD simulations further reveal that the bridged water molecules are more ordered near the catalytic triad of AChE to deter the nucleophilicity of Ser203 through intermolecular hydrogen bonding when donepezil approaches near to the active site gorge of AChE. Donepezil 204-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 31173012-8 2019 The WTMtD simulations further reveal that the bridged water molecules are more ordered near the catalytic triad of AChE to deter the nucleophilicity of Ser203 through intermolecular hydrogen bonding when donepezil approaches near to the active site gorge of AChE. Donepezil 204-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 258-262 31173012-9 2019 The presence of donepezil near the active site of AChE can inhibit its approach for ACh hydrolysis; this is revealed through the docking study, where the drug molecule inside the active gorge of hAChE restricts the approach of ACh to Ser203 for the hydrolysis process. Donepezil 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 31173012-9 2019 The presence of donepezil near the active site of AChE can inhibit its approach for ACh hydrolysis; this is revealed through the docking study, where the drug molecule inside the active gorge of hAChE restricts the approach of ACh to Ser203 for the hydrolysis process. Donepezil 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-200 31173012-9 2019 The presence of donepezil near the active site of AChE can inhibit its approach for ACh hydrolysis; this is revealed through the docking study, where the drug molecule inside the active gorge of hAChE restricts the approach of ACh to Ser203 for the hydrolysis process. Acetylcholine 50-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-200 31173012-9 2019 The presence of donepezil near the active site of AChE can inhibit its approach for ACh hydrolysis; this is revealed through the docking study, where the drug molecule inside the active gorge of hAChE restricts the approach of ACh to Ser203 for the hydrolysis process. Acetylcholine 84-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 31173012-9 2019 The presence of donepezil near the active site of AChE can inhibit its approach for ACh hydrolysis; this is revealed through the docking study, where the drug molecule inside the active gorge of hAChE restricts the approach of ACh to Ser203 for the hydrolysis process. Acetylcholine 84-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-200 30933859-4 2019 Under the optimum conditions, the reported sensing platform AChE-Chit/MXene/Au NPs/MnO2/Mn3O4/GCE can be utilized to detect methamidophos in a broad concentration range (10-12-10-6 M), together with a good linearity (R = 0.995). methamidophos 124-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 31138650-0 2019 Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase. Oximes 36-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 31138650-2 2019 OPs inactivate acetylcholinesterase (AChE) by covalently modifying its catalytic serine. Organophosphorus Compounds 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 31138650-2 2019 OPs inactivate acetylcholinesterase (AChE) by covalently modifying its catalytic serine. Organophosphorus Compounds 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 31138650-2 2019 OPs inactivate acetylcholinesterase (AChE) by covalently modifying its catalytic serine. Serine 81-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 31138650-2 2019 OPs inactivate acetylcholinesterase (AChE) by covalently modifying its catalytic serine. Serine 81-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 31138650-3 2019 Inhibited AChE cannot hydrolyze the neurotransmitter acetylcholine leading to its build-up at the cholinergic synapses and creating an acute cholinergic crisis. Acetylcholine 53-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-14 31138650-4 2019 Current antidotes, including oxime reactivators that attack the OP-AChE conjugate to free the active enzyme, are inefficient. Oximes 29-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 31138650-6 2019 Here, we present room temperature X-ray structures of native and VX-phosphonylated hAChE with an imidazole-based oxime reactivator, RS-170B. imidazole 97-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-88 31138650-6 2019 Here, we present room temperature X-ray structures of native and VX-phosphonylated hAChE with an imidazole-based oxime reactivator, RS-170B. Oximes 113-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-88 31177620-1 2019 A set of piperonylic acid derived hydrazones with variable isatin moieties was synthesized and evaluated for their inhibitory activity against the enzymes acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and monoamine oxidases A and B (MAO-A/B). piperonylic acid derived hydrazones 9-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-175 31177620-1 2019 A set of piperonylic acid derived hydrazones with variable isatin moieties was synthesized and evaluated for their inhibitory activity against the enzymes acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and monoamine oxidases A and B (MAO-A/B). piperonylic acid derived hydrazones 9-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-181 31946099-4 2019 This biosensor combines a pH-sensitive layer of reduced graphene oxide functionalized with 4-aminobenzoic acid and acetylcholinesterase. Graphite 56-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 29564935-0 2019 The effects of some cephalosporins on acetylcholinesterase and glutathione S-transferase: an in vivo and in vitro study. Cephalosporins 20-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 29564935-8 2019 CZO (50 mg/kg), CXM (25 mg/kg), and CFP (100 mg/kg) inhibit in vivo GST and AChE activities. Cefazolin 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 29564935-8 2019 CZO (50 mg/kg), CXM (25 mg/kg), and CFP (100 mg/kg) inhibit in vivo GST and AChE activities. Cefuroxime 16-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 29564935-9 2019 CXM had the most effective in vivo inhibition on AChE and GST. Cefuroxime 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 31030060-4 2019 In view of this, the present study was designed to synthesize and evaluate the multifunctional neuroprotective ability of the sesquiterpene glycoside alpha-bisabolol beta-D-fucopyranoside (ABFP) against multiple targets like acetylcholinesterase, oxidative stress and beta-amyloid peptide aggregation induced cytotoxicity. sesquiterpene glycoside 126-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 225-245 31030060-4 2019 In view of this, the present study was designed to synthesize and evaluate the multifunctional neuroprotective ability of the sesquiterpene glycoside alpha-bisabolol beta-D-fucopyranoside (ABFP) against multiple targets like acetylcholinesterase, oxidative stress and beta-amyloid peptide aggregation induced cytotoxicity. alpha-bisabolol beta-d-fucopyranoside 150-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 225-245 31125474-0 2019 Synthesis of 2-(2-oxo-2H-chromen-4-yl)acetamides as potent acetylcholinesterase inhibitors and molecular insights into binding interactions. 2-(2-oxo-2h-chromen-4-yl)acetamides 13-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 31125474-1 2019 Sixteen novel coumarin-based compounds are reported as potent acetylcholinesterase (AChE) inhibitors. coumarin 14-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 31125474-1 2019 Sixteen novel coumarin-based compounds are reported as potent acetylcholinesterase (AChE) inhibitors. coumarin 14-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 31125474-10 2019 Molecular docking was applied to postulate the selectivity toward AChE of 5a in comparison with donepezil and tacrine. Tacrine 110-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 31136018-3 2019 The results show that among the various synthesized compounds, analogs bearing the piperidinyl ethoxy side chain with 4-hydroxybenzylidene on the 3-positions of chroman-4-one (3l) showed the most potent activity with respect to acetylcholinesterase (anti-AChE activity; IC50 = 1.18 muM). 4-hydroxybenzylidene 118-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 255-259 31054518-0 2019 Visual detection of mixed organophosphorous pesticide using QD-AChE aerogel based microfluidic arrays sensor. organophosphorous 26-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 31102808-0 2019 Synthesis and biological evaluation of flavone-8-acrylamide derivatives as potential multi-target-directed anti Alzheimer agents and investigation of binding mechanism with acetylcholinesterase. flavone-8-acrylamide 39-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-193 31128990-1 2019 Novel 4-oxobenzo[d]1,2,3-triazin derivatives bearing pyridinium moiety 6a-q were synthesized and screened against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). 4-oxobenzo[d]1,2,3-triazin 6-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 31128990-1 2019 Novel 4-oxobenzo[d]1,2,3-triazin derivatives bearing pyridinium moiety 6a-q were synthesized and screened against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). 4-oxobenzo[d]1,2,3-triazin 6-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 31128990-1 2019 Novel 4-oxobenzo[d]1,2,3-triazin derivatives bearing pyridinium moiety 6a-q were synthesized and screened against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). 6a-q 71-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 31174010-6 2019 Inhibitory activities of enantiomerically enriched oxazolidinones (8, 10 and 12) were tested against human carbonic anhydrase I and II isoenzymes (hCA I and hCA II), acetylcholinesterase (AChE), and alpha-glycosidase (alpha-Gly) enzymes. Oxazolidinones 51-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-186 31174010-7 2019 These enantiomerically enriched oxazolidinones derivatives had Ki values in the range of 11.6 +- 2.1-66.4 +- 22.7 nM for hCA I, 34.1 +- 6.7-45.2 +- 12.9 nM for hCA II, 16.5 +- 2.9 to 35.6 +- 13.9 for AChE, and 22.3 +- 6.0-70.9 +- 9.9 nM for alpha-glycosidase enzyme. Oxazolidinones 32-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-204 31174010-9 2019 These results strongly supported the promising nature of the enantiomerically enriched oxazolidinones as selective hCA, AChE, and alpha-glycosidase inhibitors. Oxazolidinones 87-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 31004594-1 2019 Bispyridinium oximes with one (K865, K866, K867) or two (K868, K869, K870) ortho-positioned chlorine moiety, analogous to previously known K027, K048 and K203 oximes, and potent reactivators of human acetylcholinesterase (AChE) inhibited by nerve agents, were tested in the reactivation of human butyrylcholinesterase (BChE) inhibited by sarin, cyclosarin, VX, and tabun. bispyridinium oximes 0-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-220 31004594-1 2019 Bispyridinium oximes with one (K865, K866, K867) or two (K868, K869, K870) ortho-positioned chlorine moiety, analogous to previously known K027, K048 and K203 oximes, and potent reactivators of human acetylcholinesterase (AChE) inhibited by nerve agents, were tested in the reactivation of human butyrylcholinesterase (BChE) inhibited by sarin, cyclosarin, VX, and tabun. bispyridinium oximes 0-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 222-226 31004594-2 2019 A previously highlighted AChE reactivator, dichlorinated bispyridinium oxime with propyl linker (K868), was tested in more detail for reactivation of four nerve agent-BChE conjugates. dichlorinated bispyridinium oxime 43-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 31004594-2 2019 A previously highlighted AChE reactivator, dichlorinated bispyridinium oxime with propyl linker (K868), was tested in more detail for reactivation of four nerve agent-BChE conjugates. k868 97-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 31121152-0 2019 Molecular modelling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime with VX-inhibited human acetylcholinesterase. 7-methoxytacrine-4-pyridinealdoxime 51-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 31121152-2 2019 The novel prophylactic agent 7-methoxytacrine-4-pyridinealdoxime is a hybrid compound formerly designed to keep acetylcholinesterase resistant to organophosphates by reactivating it in case of intoxication by such inhibitors. 7-methoxytacrine-4-pyridinealdoxime 29-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 31150769-4 2019 Delamide A (1) showed highly selective AChE inhibition activity. delamide a 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 30672607-0 2019 Acetylcholinesterase with mesoporous silica: Covalent immobilization, physiochemical characterization, and its application in food for pesticide detection. Silicon Dioxide 37-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 31121152-2 2019 The novel prophylactic agent 7-methoxytacrine-4-pyridinealdoxime is a hybrid compound formerly designed to keep acetylcholinesterase resistant to organophosphates by reactivating it in case of intoxication by such inhibitors. Organophosphates 146-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 31112674-5 2019 The central compartment is readily accessible by the OPs which are lipophilic bullets that can easily cross the BBB, whereas first-line therapeutics, namely oxime-based AChE reactivators and atropine, do not cross or do so rather slowly. Oximes 157-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 31112674-6 2019 The limitation of oxime-based AChE reactivators can be ascribed to their chemical nature, bearing a positive charge which is essential either for their AChE affinity or their reactivating potency. Oximes 18-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 31112674-6 2019 The limitation of oxime-based AChE reactivators can be ascribed to their chemical nature, bearing a positive charge which is essential either for their AChE affinity or their reactivating potency. Oximes 18-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 31261693-0 2019 Synthesis and AChE Inhibitory Activity of Novel Thiazolylhydrazone Derivatives. thiazolylhydrazone 48-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 31249381-3 2019 In this work, we select four enzymes (urease, acetylcholinesterase, glucose oxidase, and aldolase) to be attached on silica microcapsules and study how their turnover number and conformational dynamics affect the self-propulsion, combining both an experimental and molecular dynamics simulations approach. Silicon Dioxide 117-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 31035749-3 2019 Selenepezil, a selenium-based compound, was previously found to exhibit excellent acetylcholinesterase (AChE) inhibition, to mimic endogenous glutathione peroxidase (GPx) activity, and to exhibit scavenging activity for hydrogen peroxide in vitro. selenepezil 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 31035749-3 2019 Selenepezil, a selenium-based compound, was previously found to exhibit excellent acetylcholinesterase (AChE) inhibition, to mimic endogenous glutathione peroxidase (GPx) activity, and to exhibit scavenging activity for hydrogen peroxide in vitro. selenepezil 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 31035749-3 2019 Selenepezil, a selenium-based compound, was previously found to exhibit excellent acetylcholinesterase (AChE) inhibition, to mimic endogenous glutathione peroxidase (GPx) activity, and to exhibit scavenging activity for hydrogen peroxide in vitro. Selenium 15-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 31214721-0 2019 Physiologically based kinetic modelling-facilitated reverse dosimetry to predict in vivo red blood cell acetylcholinesterase inhibition following exposure to chlorpyrifos in the Caucasian and Chinese population. Chlorpyrifos 158-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 31214721-2 2019 The aim of the present study was to investigate the interethnic differences in kinetics, biomarker formation and in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition of chlorpyrifos (CPF) in the Chinese and the Caucasian population. Chlorpyrifos 184-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 31214721-2 2019 The aim of the present study was to investigate the interethnic differences in kinetics, biomarker formation and in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition of chlorpyrifos (CPF) in the Chinese and the Caucasian population. Chlorpyrifos 184-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 31214721-2 2019 The aim of the present study was to investigate the interethnic differences in kinetics, biomarker formation and in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition of chlorpyrifos (CPF) in the Chinese and the Caucasian population. Chlorpyrifos 198-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 31214721-2 2019 The aim of the present study was to investigate the interethnic differences in kinetics, biomarker formation and in vivo red blood cell (RBC) acetylcholinesterase (AChE) inhibition of chlorpyrifos (CPF) in the Chinese and the Caucasian population. Chlorpyrifos 198-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 30858091-12 2019 However, the oxime HI-6 as potent reactivator of cyclosarin-inhibited AChE was not able to prevent the FPDc prolongation in this model. Oximes 13-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 30858091-12 2019 However, the oxime HI-6 as potent reactivator of cyclosarin-inhibited AChE was not able to prevent the FPDc prolongation in this model. asoxime chloride 19-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 30858091-12 2019 However, the oxime HI-6 as potent reactivator of cyclosarin-inhibited AChE was not able to prevent the FPDc prolongation in this model. cyclohexyl methylphosphonofluoridate 49-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 31194017-0 2019 The role of acetylcholinesterase inhibitors such as neostigmine and rivastigmine on chronic pain and cognitive function in aging: A review of recent clinical applications. Neostigmine 52-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 31059278-0 2019 Potent Acetylcholinesterase Selective and Reversible Homodimeric Agent Based on Tacrine for Theranostics. Tacrine 80-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 7-27 31059278-2 2019 A potent, selective, and reversible homodimeric inhibitor of AChE, 5-amino- N1, N3-bis(2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl)isophthalamide (compound 4), was synthesized by using 9-alkyl(1,2,3,4-tetrahydroacridine) pharmacophore with appended functionality. 5-amino- n1, n3-bis(2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl)isophthalamide 67-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 31059278-2 2019 A potent, selective, and reversible homodimeric inhibitor of AChE, 5-amino- N1, N3-bis(2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl)isophthalamide (compound 4), was synthesized by using 9-alkyl(1,2,3,4-tetrahydroacridine) pharmacophore with appended functionality. 9-alkyl(1,2,3,4-tetrahydroacridine 186-220 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 31269106-5 2019 Furthermore, supplementation with SDPP (MYC+SDPP group) prevented the mycotoxin-related reduction of AChE in blood and brain. (2,5-dioxopyrrolidin-1-yl) diphenyl phosphate 34-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 31125504-3 2019 These novel pyrazoline derivatives were effective inhibitor compounds of the human carbonic anhydrase I and II isozymes (hCAs I and II) and of the acetylcholinesterase (AChE) enzyme, with Ki values in the range of 17.4-40.7 nM for hCA I, 16.1-55.2 nM for hCA II, and 48.2-84.1 nM for AChE. pyrazoline 12-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 30831354-0 2019 A sensitive amperometric AChE-biosensor for organophosphate pesticides detection based on conjugated polymer and Ag-rGO-NH2 nanocomposite. Organophosphates 44-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 30831354-0 2019 A sensitive amperometric AChE-biosensor for organophosphate pesticides detection based on conjugated polymer and Ag-rGO-NH2 nanocomposite. Polymers 101-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 30831354-4 2019 Then, Ag-rGO-NH2 nanocomposite and acetylcholinesterase (AChE) are modified on the polymer membrane surface. Polymers 83-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 30904408-2 2019 This drug is a specific inhibitor of the enzyme acetylcholinesterase (AChE), whose main physiological function is to hydrolyze the neurotransmitter acetylcholine. Acetylcholine 48-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 30904408-3 2019 The main objective of this work was to study the effect of donepezil on human erythrocytes as AChE is present in its membrane. Donepezil 59-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 30904408-9 2019 This effect was explained by the incorporation of donepezil molecules into the erythrocyte membrane and interactions with AChE. Donepezil 50-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 30538051-1 2019 A group of N-benzylpiperidine-3/4-carbohydrazide-hydrazones were designed, synthesized and evaluated for acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) activities, Abeta42 self-aggregation inhibitory potentials, and antioxidant capacities, in vitro. n-benzylpiperidine-3/4-carbohydrazide-hydrazones 11-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 30538051-1 2019 A group of N-benzylpiperidine-3/4-carbohydrazide-hydrazones were designed, synthesized and evaluated for acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) activities, Abeta42 self-aggregation inhibitory potentials, and antioxidant capacities, in vitro. n-benzylpiperidine-3/4-carbohydrazide-hydrazones 11-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 30921741-4 2019 Moreover, both kinetic analysis of AChE inhibition and molecular modeling study revealed that 7c showed a mixed-type inhibition, binding simultaneously to CAS and PAS of AChE. Protactinium 163-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 30921741-4 2019 Moreover, both kinetic analysis of AChE inhibition and molecular modeling study revealed that 7c showed a mixed-type inhibition, binding simultaneously to CAS and PAS of AChE. Protactinium 163-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 30928873-4 2019 Furthermore, the docking study of the compounds 7f and 7i showed that these compounds bound to both the catalytic site (CS) and peripheral anionic site (PAS) of AChE and BuChE, respectively. Aminosalicylic Acid 153-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-165 30956012-2 2019 In this work, a new series of 4-N-phenylaminoquinolines was synthesized and evaluated for their abilities to inhibit AChE and BChE. 4-n-phenylaminoquinolines 30-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 30956012-3 2019 Compound 11b showed significant inhibitory activities on AChE and BChE with IC50 values of 0.86 and 2.65 muM, respectively, a lot better than that of reference drug galanthamine. Galantamine 165-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 30956012-4 2019 Furthermore, docking study showed that compound 11b interacted simultaneously not only with active and peripheral sites of AChE, but also with all five regions of BChE active site. 11b 48-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 30956014-0 2019 Cu-mediated synthesis of differentially substituted diazepines as AChE inhibitors; validation through molecular docking and Lipinski"s filter to develop novel anti-neurodegenerative drugs. Copper 0-2 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 30956014-0 2019 Cu-mediated synthesis of differentially substituted diazepines as AChE inhibitors; validation through molecular docking and Lipinski"s filter to develop novel anti-neurodegenerative drugs. diazepines 52-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 30851527-10 2019 A significant increase in the AChE activity was observed after exposure to MC-LR in undifferentiated cells, and after exposure to the combination of both cyanotoxins on differentiated cells. cyanoginosin LR 75-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 30851527-11 2019 However, CYN decreased the AChE activity only on differentiated cultures. cylindrospermopsin 9-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 30451024-1 2019 BACKGROUND: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are used in clinical management to confirm the diagnosis and indicate the severity of organophosphorus and carbamate poisoning. organophosphorus 159-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 30451024-1 2019 BACKGROUND: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are used in clinical management to confirm the diagnosis and indicate the severity of organophosphorus and carbamate poisoning. organophosphorus 159-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 30451024-1 2019 BACKGROUND: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are used in clinical management to confirm the diagnosis and indicate the severity of organophosphorus and carbamate poisoning. Carbamates 180-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 30451024-1 2019 BACKGROUND: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are used in clinical management to confirm the diagnosis and indicate the severity of organophosphorus and carbamate poisoning. Carbamates 180-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 31170561-8 2019 The value of free binding energy of paraoxon with peripheral anionic site of acetylcholinesterase (AChE) has been calculated as well. Paraoxon 36-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 31170561-8 2019 The value of free binding energy of paraoxon with peripheral anionic site of acetylcholinesterase (AChE) has been calculated as well. Paraoxon 36-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 31170561-9 2019 It has been revealed that the aptamers found bind paraoxon more effectively than AChE. Paraoxon 50-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 31170562-1 2019 A series of novel tacrine derivatives as multifunctional agents with potential inhibitory effects on both acetylcholinesterase(AChE) and butyrylcholinesterase (BuChE) enzymes for the treatment of Alzheimer"s disease(AD), were applied to alignment independent 3D-QSAR methods using Pentacle software. Tacrine 18-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 31170562-3 2019 Two H-bond acceptor groups as well as hydrophobic properties of tacrine rings for AChE and two H-bond acceptor on the carbonyl group of chromene and NH of amid group for BuChE, with positive effects on their inhibitory potency have been identified. Tacrine 64-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 31170562-3 2019 Two H-bond acceptor groups as well as hydrophobic properties of tacrine rings for AChE and two H-bond acceptor on the carbonyl group of chromene and NH of amid group for BuChE, with positive effects on their inhibitory potency have been identified. Benzopyrans 136-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 30680760-0 2019 Structure-activity study of fluorine or chlorine-substituted cinnamic acid derivatives with tertiary amine side chain in acetylcholinesterase and butyrylcholinesterase inhibition. Fluorine 28-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 30680760-0 2019 Structure-activity study of fluorine or chlorine-substituted cinnamic acid derivatives with tertiary amine side chain in acetylcholinesterase and butyrylcholinesterase inhibition. Chlorine 40-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 30680760-0 2019 Structure-activity study of fluorine or chlorine-substituted cinnamic acid derivatives with tertiary amine side chain in acetylcholinesterase and butyrylcholinesterase inhibition. cinnamic acid 61-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 30680760-0 2019 Structure-activity study of fluorine or chlorine-substituted cinnamic acid derivatives with tertiary amine side chain in acetylcholinesterase and butyrylcholinesterase inhibition. Amines 101-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 30680760-1 2019 In this study, a series of new fluorine or chlorine-substituted cinnamic acid derivatives that contain tertiary amine side chain were designed, synthesized, and evaluated in acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition. Fluorine 31-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-194 30680760-1 2019 In this study, a series of new fluorine or chlorine-substituted cinnamic acid derivatives that contain tertiary amine side chain were designed, synthesized, and evaluated in acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition. Fluorine 31-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 196-200 30680760-1 2019 In this study, a series of new fluorine or chlorine-substituted cinnamic acid derivatives that contain tertiary amine side chain were designed, synthesized, and evaluated in acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition. Chlorine 43-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-194 30680760-1 2019 In this study, a series of new fluorine or chlorine-substituted cinnamic acid derivatives that contain tertiary amine side chain were designed, synthesized, and evaluated in acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition. cinnamic acid 64-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-194 30680760-1 2019 In this study, a series of new fluorine or chlorine-substituted cinnamic acid derivatives that contain tertiary amine side chain were designed, synthesized, and evaluated in acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition. cinnamic acid 64-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 196-200 30680760-2 2019 The results show that almost all the derivatives containing tertiary amine side chain (compounds 4a-9d) exhibit moderate or potent activity in AChE inhibition. Amines 69-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 30680760-4 2019 For the compounds containing pyrroline or piperidine side chain, the bioactivity in AChE inhibition is much intense than those containing N,N-diethylamino side chain. pyrroline 29-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 30680760-4 2019 For the compounds containing pyrroline or piperidine side chain, the bioactivity in AChE inhibition is much intense than those containing N,N-diethylamino side chain. piperidine 42-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 30680760-4 2019 For the compounds containing pyrroline or piperidine side chain, the bioactivity in AChE inhibition is much intense than those containing N,N-diethylamino side chain. n,n-diethylamino 138-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 30680760-5 2019 The chlorine or fluorine substituted position produces a significant effect on the bioactivity and selectivity in AChE inhibition. Chlorine 4-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 30680760-5 2019 The chlorine or fluorine substituted position produces a significant effect on the bioactivity and selectivity in AChE inhibition. Fluorine 16-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 30680760-6 2019 Most of the compounds that contain para-substituted fluorine or chlorine exhibit potent activity against AChE and poor activity against BChE, while ortho-substituted analogs show the opposite effect. para-substituted fluorine 35-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 30680760-6 2019 Most of the compounds that contain para-substituted fluorine or chlorine exhibit potent activity against AChE and poor activity against BChE, while ortho-substituted analogs show the opposite effect. Chlorine 64-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 30991225-8 2019 The AChE inhibition bioassay indicated that ICPO is the only effective inhibitor of AChE. icpo 44-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 30991225-8 2019 The AChE inhibition bioassay indicated that ICPO is the only effective inhibitor of AChE. icpo 44-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 31162119-4 2019 Acetylcholinesterase inhibitors (donepezil or rivastigmine) were studied in several double-blind placebo-controlled studies. Donepezil 33-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 31162119-4 2019 Acetylcholinesterase inhibitors (donepezil or rivastigmine) were studied in several double-blind placebo-controlled studies. Rivastigmine 46-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 30672607-2 2019 This study reports on Santa Barbara Amorphous (SBA-15), a type of mesoporous silica nanoparticles, for efficient and stable acetylcholinesterase (AChE) adhesion toward detection of toxic pesticides. Silicon Dioxide 77-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 30672607-2 2019 This study reports on Santa Barbara Amorphous (SBA-15), a type of mesoporous silica nanoparticles, for efficient and stable acetylcholinesterase (AChE) adhesion toward detection of toxic pesticides. Silicon Dioxide 77-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 30672607-8 2019 Enzyme stability was also studied, which exhibited that immobilized AChE retained its catalytic activity up to 60 days and retained 80% of the hydrolytic activity even at 37 C. On the basis of the success of immobilized enzyme (covalent) being inhibited by acetylthiocholine, the sensor was administered for the inhibition by monocrotophos and dimethoate that are used widely as pesticides in agricultural. Acetylthiocholine 257-274 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 30672607-8 2019 Enzyme stability was also studied, which exhibited that immobilized AChE retained its catalytic activity up to 60 days and retained 80% of the hydrolytic activity even at 37 C. On the basis of the success of immobilized enzyme (covalent) being inhibited by acetylthiocholine, the sensor was administered for the inhibition by monocrotophos and dimethoate that are used widely as pesticides in agricultural. Monocrotophos 326-339 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 30672607-8 2019 Enzyme stability was also studied, which exhibited that immobilized AChE retained its catalytic activity up to 60 days and retained 80% of the hydrolytic activity even at 37 C. On the basis of the success of immobilized enzyme (covalent) being inhibited by acetylthiocholine, the sensor was administered for the inhibition by monocrotophos and dimethoate that are used widely as pesticides in agricultural. Dimethoate 344-354 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 30672607-9 2019 The inhibitory concentration (IC50 ) value was found to be 2.5 ppb for monocrotophos and 1.5 ppb for dimethoate inhibiting immobilized AChE. Dimethoate 101-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 30672607-10 2019 This was verified using cyclic voltammetry, an electrochemical analysis thus proving that the SBA-15@AChE complex could be used as a sensitive and highly stable sensor for detecting the concentration of hazardous pesticide compounds. SBA-15 94-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 30950246-1 2019 Intoxications caused by organophosphorus compounds (OPs) are associated with the reversible, and sometimes irreversible interaction with acetylcholinesterase (AChE). Organophosphorus Compounds 24-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 30950246-1 2019 Intoxications caused by organophosphorus compounds (OPs) are associated with the reversible, and sometimes irreversible interaction with acetylcholinesterase (AChE). Organophosphorus Compounds 24-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 30950246-1 2019 Intoxications caused by organophosphorus compounds (OPs) are associated with the reversible, and sometimes irreversible interaction with acetylcholinesterase (AChE). Organophosphorus Compounds 52-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 30950246-1 2019 Intoxications caused by organophosphorus compounds (OPs) are associated with the reversible, and sometimes irreversible interaction with acetylcholinesterase (AChE). Organophosphorus Compounds 52-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 30950246-3 2019 The current antidotes are oxime-based drugs that can regenerate the AChE catalytic activity. Oximes 26-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 30993792-1 2019 Serving a critical role in neurotransmission, human acetylcholinesterase (hAChE) is the target of organophosphate nerve agents. Organophosphates 98-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-79 30763608-9 2019 Both substances restored AChE activity in a dose-dependent way, with HI-6 being more potent (HI-6 EC50 = 3.8 muM vs obidoxime EC50 = 197.8 muM). asoxime chloride 69-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 30876606-9 2019 Thiocholine (TCh), which produced from acetylthiocholine(ATCh) by the hydrolysis of acetylcholinesterase (AChE), can "turn on" the fluorescence sensor. Thiocholine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 30876606-9 2019 Thiocholine (TCh), which produced from acetylthiocholine(ATCh) by the hydrolysis of acetylcholinesterase (AChE), can "turn on" the fluorescence sensor. Thiocholine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 30876606-9 2019 Thiocholine (TCh), which produced from acetylthiocholine(ATCh) by the hydrolysis of acetylcholinesterase (AChE), can "turn on" the fluorescence sensor. Thiocholine 13-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 30876606-9 2019 Thiocholine (TCh), which produced from acetylthiocholine(ATCh) by the hydrolysis of acetylcholinesterase (AChE), can "turn on" the fluorescence sensor. Thiocholine 13-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 30876606-9 2019 Thiocholine (TCh), which produced from acetylthiocholine(ATCh) by the hydrolysis of acetylcholinesterase (AChE), can "turn on" the fluorescence sensor. Acetylthiocholine 39-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 30876606-9 2019 Thiocholine (TCh), which produced from acetylthiocholine(ATCh) by the hydrolysis of acetylcholinesterase (AChE), can "turn on" the fluorescence sensor. Acetylthiocholine 39-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 30876606-9 2019 Thiocholine (TCh), which produced from acetylthiocholine(ATCh) by the hydrolysis of acetylcholinesterase (AChE), can "turn on" the fluorescence sensor. atch 57-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 30876606-9 2019 Thiocholine (TCh), which produced from acetylthiocholine(ATCh) by the hydrolysis of acetylcholinesterase (AChE), can "turn on" the fluorescence sensor. atch 57-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 30978400-0 2019 Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase. pyridine 50-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 30978400-1 2019 Tabun represents the phosphoramidate class of organophosphates that are covalent inhibitors of acetylcholinesterase (AChE), an essential enzyme in neurotransmission. phosphoramidic acid 21-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 30978400-1 2019 Tabun represents the phosphoramidate class of organophosphates that are covalent inhibitors of acetylcholinesterase (AChE), an essential enzyme in neurotransmission. phosphoramidic acid 21-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 30978400-1 2019 Tabun represents the phosphoramidate class of organophosphates that are covalent inhibitors of acetylcholinesterase (AChE), an essential enzyme in neurotransmission. Organophosphates 46-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 30978400-1 2019 Tabun represents the phosphoramidate class of organophosphates that are covalent inhibitors of acetylcholinesterase (AChE), an essential enzyme in neurotransmission. Organophosphates 46-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 30978400-2 2019 Currently used therapy in counteracting excessive cholinergic stimulation consists of a muscarinic antagonist (atropine) and an oxime reactivator of inhibited AChE, but the classical oximes are particularly ineffective in counteracting tabun exposure. Oximes 128-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 30978400-3 2019 In a recent publication (Kovarik et al., 2019), we showed that several oximes prepared by the Huisgen 1,3 dipolar cycloaddition and related precursors efficiently reactivate the tabun-AChE conjugate. Oximes 71-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-188 30978400-4 2019 Herein, we pursue the antidotal question further and examine a series of lead precursor molecules, along with triazole compounds, as reactivators of two AChE mutant enzymes. Triazoles 110-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 30978400-5 2019 Such studies should reveal structural subtleties that reside within the architecture of the active center gorge of AChE and uncover intimate mechanisms of reactivation of alkylphosphate conjugates of AChE. alkylphosphate 171-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-204 30978400-7 2019 Indeed, after initial screening of the triazole oxime library and its precursors for the reactivation efficacy on Y337A and Y337A/F338A human AChE mutants, we found potentially active oxime-mutant enzyme pairs capable of degrading tabun in cycles of inhibition and reactivation. triazole oxime 39-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 30978400-7 2019 Indeed, after initial screening of the triazole oxime library and its precursors for the reactivation efficacy on Y337A and Y337A/F338A human AChE mutants, we found potentially active oxime-mutant enzyme pairs capable of degrading tabun in cycles of inhibition and reactivation. Oximes 48-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 30978400-7 2019 Indeed, after initial screening of the triazole oxime library and its precursors for the reactivation efficacy on Y337A and Y337A/F338A human AChE mutants, we found potentially active oxime-mutant enzyme pairs capable of degrading tabun in cycles of inhibition and reactivation. tabun 231-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 30978400-9 2019 Hence, although the use of mutant enzyme bio-scavengers in humans may be limited in practicality, bioscavenging and efficient neutralization of tabun itself or phosphoramidate mixtures of organophosphates might be achieved efficiently in vitro or ex vivo with these mutant AChE combinations. tabun 144-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 273-277 31139552-6 2019 These results allowed us to establish that pyridine substituent remarkably influences activation energy and reaction yield, as well as in acetylcholinesterase (AChE) activity. pyridine 43-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 31139552-6 2019 These results allowed us to establish that pyridine substituent remarkably influences activation energy and reaction yield, as well as in acetylcholinesterase (AChE) activity. pyridine 43-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 31041959-0 2019 Acetylcholine-responsive cargo release using acetylcholinesterase-capped nanomaterials. Acetylcholine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 31193469-0 2019 Synthesis, crystal structures, Hirshfeld surface analysis and spectroscopic studies of two Schiff bases of anisaldehyde and their urease and acetylcholinesterase inhibitory and antioxidant properties. Schiff Bases 91-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 31193469-0 2019 Synthesis, crystal structures, Hirshfeld surface analysis and spectroscopic studies of two Schiff bases of anisaldehyde and their urease and acetylcholinesterase inhibitory and antioxidant properties. 4-anisaldehyde 107-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 31041959-1 2019 Mesoporous silica nanoparticles capped with acetylcholinesterase, through boronic ester linkages, selectively release an entrapped cargo in the presence of acetylcholine. Silicon Dioxide 11-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 31041959-1 2019 Mesoporous silica nanoparticles capped with acetylcholinesterase, through boronic ester linkages, selectively release an entrapped cargo in the presence of acetylcholine. boronic ester 74-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 31042679-3 2019 The fluorescence intensity of N-methyl mesoporphyrin IX (NMM) binding G-quadruplex could be turn off because of inhibiting effect of the pesticides on the acetylcholinesterase (AChE) activity. N-methylmesoporphyrin IX 30-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-175 31020297-0 2019 A sensitive fluorescence assay of organophosphorus pesticides using acetylcholinesterase and copper-catalyzed click chemistry. organophosphorus 34-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 31020297-2 2019 A sensitive fluorescence assay for organophosphorus pesticides was developed using the inhibition of acetylcholinesterase (AChE) activity and the copper-catalyzed click chemical reaction. organophosphorus 35-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 31020297-2 2019 A sensitive fluorescence assay for organophosphorus pesticides was developed using the inhibition of acetylcholinesterase (AChE) activity and the copper-catalyzed click chemical reaction. organophosphorus 35-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 31020297-4 2019 AChE can hydrolyze acetylthiocholine (ATCh) to form thiocholine (TCh) which contains a thiol group. Acetylthiocholine 19-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 31020297-4 2019 AChE can hydrolyze acetylthiocholine (ATCh) to form thiocholine (TCh) which contains a thiol group. Acetylthiocholine 38-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 31020297-4 2019 AChE can hydrolyze acetylthiocholine (ATCh) to form thiocholine (TCh) which contains a thiol group. Thiocholine 25-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 31020297-4 2019 AChE can hydrolyze acetylthiocholine (ATCh) to form thiocholine (TCh) which contains a thiol group. Thiocholine 39-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 31020297-4 2019 AChE can hydrolyze acetylthiocholine (ATCh) to form thiocholine (TCh) which contains a thiol group. Sulfhydryl Compounds 87-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 31020297-6 2019 But in the presence of OPs, the activity of AChE is inhibited, releasing a high concentration of copper ions that catalyze the click chemical reaction and resulting in decreased fluorescence signals. Copper 97-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 31011780-1 2019 Acetylcholinesterase (AChE) biosensor technology is widely applied in the detection of organophosphate pesticides in agricultural production via the inhibition of AChE activity by organophosphates. Organophosphates 87-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 31011780-1 2019 Acetylcholinesterase (AChE) biosensor technology is widely applied in the detection of organophosphate pesticides in agricultural production via the inhibition of AChE activity by organophosphates. Organophosphates 87-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 31011780-1 2019 Acetylcholinesterase (AChE) biosensor technology is widely applied in the detection of organophosphate pesticides in agricultural production via the inhibition of AChE activity by organophosphates. Organophosphates 87-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 31011780-1 2019 Acetylcholinesterase (AChE) biosensor technology is widely applied in the detection of organophosphate pesticides in agricultural production via the inhibition of AChE activity by organophosphates. Organophosphates 180-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 31011780-1 2019 Acetylcholinesterase (AChE) biosensor technology is widely applied in the detection of organophosphate pesticides in agricultural production via the inhibition of AChE activity by organophosphates. Organophosphates 180-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 31011780-1 2019 Acetylcholinesterase (AChE) biosensor technology is widely applied in the detection of organophosphate pesticides in agricultural production via the inhibition of AChE activity by organophosphates. Organophosphates 180-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 31011780-3 2019 Combining the advantages of multiwalled carbon nanotubes (MWCNTs) and ionic liquids, we constructed a novel bienzyme electrode [Cl/iron porphyrin (FePP)-modified MWCNTs/AChE/glassy carbon electrode], which included AChE and mimetic oxidase FePP. iron porphyrin 131-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 31011780-8 2019 Graphical abstract The complete synthesis process of Cl/FePP-MWCNTs/AChE/GCE. fepp-mwcnts 56-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 31141559-5 2019 RESULTS: We found that propofol indeed reduced the activity of AChE / BChE in our in-vitro model, without affecting the protein levels. Propofol 23-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 31304000-2 2019 Among these, 3d, 3e, 3g, and 3h were established as the most potent and selective BChE inhibitors (IC50 = 0.5-3.9 muM), while 3f presented dual inhibitory activity against BChE and AChE (IC50 = 6.0 and 6.5 muM, respectively). Tritium 29-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 30822441-1 2019 Acetylcholinesterase (AChE) is the primary target of organophosphorus pesticides (OPs). organophosphorus 53-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 30822441-1 2019 Acetylcholinesterase (AChE) is the primary target of organophosphorus pesticides (OPs). organophosphorus 53-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 30822441-1 2019 Acetylcholinesterase (AChE) is the primary target of organophosphorus pesticides (OPs). OPS 82-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 30822441-1 2019 Acetylcholinesterase (AChE) is the primary target of organophosphorus pesticides (OPs). OPS 82-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 30822441-2 2019 Ellman"s method using Acetylthiocholine (ATCh) is the standard approach for the detection of AChE activity. Acetylthiocholine 22-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 30822441-2 2019 Ellman"s method using Acetylthiocholine (ATCh) is the standard approach for the detection of AChE activity. Acetylthiocholine 41-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 30822441-5 2019 In the present work, we have used 1-Naphthyl acetate (1-NA) as a fluorogenic substrate for the estimation of AChE activity of human erythrocytes. alpha-naphthyl acetate 34-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 30822441-5 2019 In the present work, we have used 1-Naphthyl acetate (1-NA) as a fluorogenic substrate for the estimation of AChE activity of human erythrocytes. 1-na 54-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 30822441-7 2019 Therefore, using 1-NA, we have developed a rapid, sensitive and baseline free assay for the estimation of AChE activity. 1-na 17-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 30711701-2 2019 All imidazole derivatives were tested for AChE and BChE inhibition and showed nanomolar activity similar to that of the test compound donepezil and higher than that of tacrine. imidazole 4-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 30743172-0 2019 Investigation of inhibitory properties of some hydrazone compounds on hCA I, hCA II and AChE enzymes. Hydrazones 47-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 30743172-2 2019 Keeping this in mind, N,N"-bis[(1-aryl-3-heteroaryl)propylidene]hydrazine dihydrochlorides, N1-N11, P1, P4-P8, and R1-R6, were synthesized to investigate their inhibitory activity against hCA I, hCA II, and AChE enzymes. n,n"-bis[(1-aryl-3-heteroaryl)propylidene]hydrazine dihydrochlorides 22-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-211 30743172-3 2019 All compounds in N, P, and R-series inhibited hCAs (I and II) and AChE more efficiently than the reference compounds acetazolamide (AZA), and tacrine. Neptunium 17-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 30743172-3 2019 All compounds in N, P, and R-series inhibited hCAs (I and II) and AChE more efficiently than the reference compounds acetazolamide (AZA), and tacrine. Arginine 27-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 31042679-3 2019 The fluorescence intensity of N-methyl mesoporphyrin IX (NMM) binding G-quadruplex could be turn off because of inhibiting effect of the pesticides on the acetylcholinesterase (AChE) activity. N-methylmesoporphyrin IX 30-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-181 31042679-3 2019 The fluorescence intensity of N-methyl mesoporphyrin IX (NMM) binding G-quadruplex could be turn off because of inhibiting effect of the pesticides on the acetylcholinesterase (AChE) activity. N-methylmesoporphyrin IX 57-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-175 31042679-3 2019 The fluorescence intensity of N-methyl mesoporphyrin IX (NMM) binding G-quadruplex could be turn off because of inhibiting effect of the pesticides on the acetylcholinesterase (AChE) activity. N-methylmesoporphyrin IX 57-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-181 30836234-0 2019 Synthesis of 5-methyl-2,4-dihydro-3H-1,2,4-triazole-3-one"s aryl Schiff base derivatives and investigation of carbonic anhydrase and cholinesterase (AChE, BuChE) inhibitory properties. 5-methyl-2,4-dihydro-3h-1,2,4-triazole-3-one 13-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 30801949-5 2019 An epimeric mixture of a haemanthamine-type compound (6-hydroxymaritidine) was tested as an inhibitor against acetyl- and butyrylcholinesterase enzymes (AChE and BChE, respectively), two enzymes relevant in the treatment of Alzheimer"s disease, with good results. 6-hydroxymaritidine 54-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 31003551-0 2019 Novel Carbon/PEDOT/PSS-Based Screen-Printed Biosensors for Acetylcholine Neurotransmitter and Acetylcholinesterase Detection in Human Serum. Carbon 6-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-114 30769267-0 2019 Synthesis, biological evaluation and molecular docking of novel pyrazole derivatives as potent carbonic anhydrase and acetylcholinesterase inhibitors. pyrazole 64-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 30811749-0 2019 Investigation of the effects of some sulfonamides on acetylcholinesterase and carbonic anhydrase enzymes. Sulfonamides 37-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 30811749-2 2019 In this study, we investigated the inhibition effects of some sulfonamides on hCA I, hCA II, and AChE enzymes. Sulfonamides 62-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 29749305-0 2019 Molecular modeling studies on the interactions of aflatoxin B1 and its metabolites with the peripheral anionic site of human acetylcholinesterase. Aflatoxin B1 50-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 29749305-4 2019 AFB1 is also a mixed inhibitor of the enzyme acetylcholinesterase (AChE). Aflatoxin B1 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 29749305-4 2019 AFB1 is also a mixed inhibitor of the enzyme acetylcholinesterase (AChE). Aflatoxin B1 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 29749305-6 2019 In order to investigate this, we performed inedited molecular modeling studies on the interactions of AFB1 and its metabolites inside the peripheral anionic site of human AChE (HssAChE), to verify their stability, suggest the preferential ways of inhibition, and compare their behavior to each other. Aflatoxin B1 102-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 30765424-3 2019 Acetylcholinesterase inhibitors, such as donepezil, can cause bleeding in patients, but the underlying mechanisms are not well understood. Donepezil 41-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 30765424-8 2019 Furthermore, drugs inhibiting acetylcholinesterase, such as donepezil, also inhibit platelet activation, suggesting that platelets release acetylcholine. Donepezil 60-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 30707915-1 2019 The pathogenesis of Alzheimer"s disease (AD) is involved in the aggregation of misfolded amyloid beta (Abeta), which upregulates the activity of acetylcholinesterase (AChE), increases the production of reactive oxygen species (ROS), enhances neuroinflammation, and eventually leads to neuronal death. Reactive Oxygen Species 202-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 30707915-1 2019 The pathogenesis of Alzheimer"s disease (AD) is involved in the aggregation of misfolded amyloid beta (Abeta), which upregulates the activity of acetylcholinesterase (AChE), increases the production of reactive oxygen species (ROS), enhances neuroinflammation, and eventually leads to neuronal death. Reactive Oxygen Species 202-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 30707915-1 2019 The pathogenesis of Alzheimer"s disease (AD) is involved in the aggregation of misfolded amyloid beta (Abeta), which upregulates the activity of acetylcholinesterase (AChE), increases the production of reactive oxygen species (ROS), enhances neuroinflammation, and eventually leads to neuronal death. Reactive Oxygen Species 227-230 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 30707915-1 2019 The pathogenesis of Alzheimer"s disease (AD) is involved in the aggregation of misfolded amyloid beta (Abeta), which upregulates the activity of acetylcholinesterase (AChE), increases the production of reactive oxygen species (ROS), enhances neuroinflammation, and eventually leads to neuronal death. Reactive Oxygen Species 227-230 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 30821663-9 2019 RESULTS: The behavioral, biochemical and histopathological studies revealed that oral pre-treatment with JM-20 (8 mg/kg) significantly attenuated the scopolamine-induced memory deficits, mitochondrial malfunction, oxidative stress, and prevented AChE hyperactivity probably due to specific inhibition of AChE enzyme. jm-20 105-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 246-250 30821663-9 2019 RESULTS: The behavioral, biochemical and histopathological studies revealed that oral pre-treatment with JM-20 (8 mg/kg) significantly attenuated the scopolamine-induced memory deficits, mitochondrial malfunction, oxidative stress, and prevented AChE hyperactivity probably due to specific inhibition of AChE enzyme. jm-20 105-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 304-308 31303584-1 2019 Twelve derivatives of dihydropyridine derivatives (6-17) were synthesized and evaluated for in-vitro cholinesterases (AChE, BChE) inhibitory activity. 1,4-dihydropyridine 22-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 31303584-2 2019 All compounds showed potent activity with IC50 values between 0.21+-0.003 to 147.14+-0.12muM for AChE and among them five compounds showed potent activity with IC50 values 17.16+-0.02 to 231.6+-0.12muM for BChE when compared with standard Eserine (IC50 = 0.85+-0.0001 muM (AChE) & 0.04+-0.0001muM (BChE). Adenosine Monophosphate 280-283 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 31035318-1 2019 New insecticides are needed for control of disease-vectoring mosquitoes and this research evaluates the activity of new carbamate acetylcholinesterase (AChE) inhibitors. Carbamates 120-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 31035318-5 2019 Similarly, installation of a hexyl substituent at C6 drastically reduced inhibition of AgAChE, but showed a smaller reduction in the inhibition of hAChE. dipicrylamine 29-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-152 31035318-6 2019 A series of 4-carboxamido analogs of the parent compound gave reduced activity against AgAChE and generally showed more activity against hAChE than AgAChE. 4-carboxamido 12-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-142 32254993-1 2019 Colorimetric detection of acetylcholinesterase (AChE) and its inhibitor organophosphates (OPs) is attractive for its convenience, but the addition of exogenous catalyst to produce a chromogenic agent may result in complexity and interference. Organophosphates 72-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 32254993-1 2019 Colorimetric detection of acetylcholinesterase (AChE) and its inhibitor organophosphates (OPs) is attractive for its convenience, but the addition of exogenous catalyst to produce a chromogenic agent may result in complexity and interference. Organophosphates 90-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 32254993-2 2019 Herein, we first found that acetylcholine (ATCh) itself mimicked peroxidase"s activity, based on which a simple and reliable colorimetric system containing ATCh- 3,3",5,5"-tetramethylbenzidine (TMB)-H2O2 was developed for the sensitive and selective assay of AChE activity and its inhibitor OPs. Acetylcholine 28-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 259-263 32254993-2 2019 Herein, we first found that acetylcholine (ATCh) itself mimicked peroxidase"s activity, based on which a simple and reliable colorimetric system containing ATCh- 3,3",5,5"-tetramethylbenzidine (TMB)-H2O2 was developed for the sensitive and selective assay of AChE activity and its inhibitor OPs. Acetylcholine 43-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 259-263 32254993-2 2019 Herein, we first found that acetylcholine (ATCh) itself mimicked peroxidase"s activity, based on which a simple and reliable colorimetric system containing ATCh- 3,3",5,5"-tetramethylbenzidine (TMB)-H2O2 was developed for the sensitive and selective assay of AChE activity and its inhibitor OPs. atch- 3,3",5,5"-tetramethylbenzidine 156-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 259-263 32254993-3 2019 Due to the AChE-catalyzed hydrolysis of acetylcholine, the peroxidase-like activity was affected, which was used for highly sensitive detection of AChE activity with a low limit of detection (LOD) of 0.5 mU mL-1 and a linear detection range from 2.0 to 14 mU mL-1. Acetylcholine 40-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-15 32254993-3 2019 Due to the AChE-catalyzed hydrolysis of acetylcholine, the peroxidase-like activity was affected, which was used for highly sensitive detection of AChE activity with a low limit of detection (LOD) of 0.5 mU mL-1 and a linear detection range from 2.0 to 14 mU mL-1. Acetylcholine 40-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 31003551-9 2019 A linear plot between the initial rate of the hydrolysis of ACh+ substrate and enzyme activity held 5.0 x 10-3-5.2 IU L-1 of AChE enzyme. Acetylcholine 60-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 30849722-0 2019 A ratiometric fluorescence probe based on carbon dots for discriminative and highly sensitive detection of acetylcholinesterase and butyrylcholinesterase in human whole blood. Carbon 42-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 30849722-1 2019 A ratiometric fluorescence probe based on carbon dots (CDs) was developed for discriminative and highly sensitive detection of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity in human whole blood. Carbon 42-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 30849722-1 2019 A ratiometric fluorescence probe based on carbon dots (CDs) was developed for discriminative and highly sensitive detection of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity in human whole blood. Carbon 42-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 30849722-1 2019 A ratiometric fluorescence probe based on carbon dots (CDs) was developed for discriminative and highly sensitive detection of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity in human whole blood. cds 55-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 30849722-1 2019 A ratiometric fluorescence probe based on carbon dots (CDs) was developed for discriminative and highly sensitive detection of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity in human whole blood. cds 55-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 30849722-3 2019 The AChE or BChE catalyzed hydrolysis reaction of acetylthiocholine or butyrylthiocholine to generate thiocholine, whose sulfhydryl group strongly captured Cu2+ to inhibit the oxidization of OPD, thus effectively preserving the natural fluorescence emission of CDs. Acetylthiocholine 50-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 30849722-3 2019 The AChE or BChE catalyzed hydrolysis reaction of acetylthiocholine or butyrylthiocholine to generate thiocholine, whose sulfhydryl group strongly captured Cu2+ to inhibit the oxidization of OPD, thus effectively preserving the natural fluorescence emission of CDs. Butyrylthiocholine 71-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 30771282-8 2019 Both rivastigmine and 4-bis-nitrophenyl phosphate inhibited plasma esterase activities, suggesting that acetylcholinesterase and carboxylesterase largely contribute to ASA hydrolysis. Rivastigmine 5-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 30849722-3 2019 The AChE or BChE catalyzed hydrolysis reaction of acetylthiocholine or butyrylthiocholine to generate thiocholine, whose sulfhydryl group strongly captured Cu2+ to inhibit the oxidization of OPD, thus effectively preserving the natural fluorescence emission of CDs. Thiocholine 56-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 30771282-8 2019 Both rivastigmine and 4-bis-nitrophenyl phosphate inhibited plasma esterase activities, suggesting that acetylcholinesterase and carboxylesterase largely contribute to ASA hydrolysis. 4-bis-nitrophenyl phosphate 22-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 30849722-3 2019 The AChE or BChE catalyzed hydrolysis reaction of acetylthiocholine or butyrylthiocholine to generate thiocholine, whose sulfhydryl group strongly captured Cu2+ to inhibit the oxidization of OPD, thus effectively preserving the natural fluorescence emission of CDs. cupric ion 156-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 30771282-8 2019 Both rivastigmine and 4-bis-nitrophenyl phosphate inhibited plasma esterase activities, suggesting that acetylcholinesterase and carboxylesterase largely contribute to ASA hydrolysis. Aspirin 168-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 30849722-3 2019 The AChE or BChE catalyzed hydrolysis reaction of acetylthiocholine or butyrylthiocholine to generate thiocholine, whose sulfhydryl group strongly captured Cu2+ to inhibit the oxidization of OPD, thus effectively preserving the natural fluorescence emission of CDs. 1,2-diaminobenzene 191-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 30849722-3 2019 The AChE or BChE catalyzed hydrolysis reaction of acetylthiocholine or butyrylthiocholine to generate thiocholine, whose sulfhydryl group strongly captured Cu2+ to inhibit the oxidization of OPD, thus effectively preserving the natural fluorescence emission of CDs. cds 261-264 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 30849722-6 2019 Additionally, the IC50 of tacrine and ethopropazine for the inhibition of AChE and BChE were estimated to be 29.8 nM and 132.6 nM, respectively. Tacrine 26-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 30849722-6 2019 Additionally, the IC50 of tacrine and ethopropazine for the inhibition of AChE and BChE were estimated to be 29.8 nM and 132.6 nM, respectively. profenamine 38-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 30851693-2 2019 Based on the in vitro biological profile, compound S-K1035 was found to be the most potent inhibitor of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE), demonstrating balanced IC50 values of 6.3 and 9.1 nM, respectively. Sulfur 51-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-137 30798053-2 2019 Two scaffolds, targeting AChE (tacrine) and GSK-3alpha/beta (valmerin) simultaneously, were assembled, using copper(I)-catalysed azide alkyne cycloaddition (CuAAC), to generate a new series of multifunctional ligands. Tacrine 31-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 30798053-2 2019 Two scaffolds, targeting AChE (tacrine) and GSK-3alpha/beta (valmerin) simultaneously, were assembled, using copper(I)-catalysed azide alkyne cycloaddition (CuAAC), to generate a new series of multifunctional ligands. cuprous ion 109-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 30798053-2 2019 Two scaffolds, targeting AChE (tacrine) and GSK-3alpha/beta (valmerin) simultaneously, were assembled, using copper(I)-catalysed azide alkyne cycloaddition (CuAAC), to generate a new series of multifunctional ligands. azide alkyne 129-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 30444932-5 2019 Oxime nucleophiles can reactivate select OP-inhibited acetylcholinesterase (AChE). Oximes 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 30444932-5 2019 Oxime nucleophiles can reactivate select OP-inhibited acetylcholinesterase (AChE). Oximes 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 30444932-12 2019 Mannich bases not only serve as reactivators of OP-inhibited AChE, but this class of compounds can also recover activity from the aged form of AChE, a process referred to as resurrection. Mannich Bases 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 30444932-12 2019 Mannich bases not only serve as reactivators of OP-inhibited AChE, but this class of compounds can also recover activity from the aged form of AChE, a process referred to as resurrection. Mannich Bases 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 30555106-0 2019 Efficient Preservation of Acetylcholinesterase at Room Temperature for Facile Detection of Organophosphorus Pesticide. organophosphorus 91-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 30555106-1 2019 A simple and inexpensive strategy is reported to facilitate the detection of an organophosphorus pesticide by acetylcholinesterase (AChE). organophosphorus 80-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 30555106-1 2019 A simple and inexpensive strategy is reported to facilitate the detection of an organophosphorus pesticide by acetylcholinesterase (AChE). organophosphorus 80-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 30555106-7 2019 The feasibility of activated AChE for organophosphorus pesticide detection was evaluated using malaoxon. organophosphorus 38-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 30555106-7 2019 The feasibility of activated AChE for organophosphorus pesticide detection was evaluated using malaoxon. malaoxon 95-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 30888170-0 2019 Fabricating an Acetylcholinesterase Modulated UCNPs-Cu2+ Fluorescence Biosensor for Ultrasensitive Detection of Organophosphorus Pesticides-Diazinon in Food. cupric ion 52-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 30888170-0 2019 Fabricating an Acetylcholinesterase Modulated UCNPs-Cu2+ Fluorescence Biosensor for Ultrasensitive Detection of Organophosphorus Pesticides-Diazinon in Food. organophosphorus 112-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 30888170-0 2019 Fabricating an Acetylcholinesterase Modulated UCNPs-Cu2+ Fluorescence Biosensor for Ultrasensitive Detection of Organophosphorus Pesticides-Diazinon in Food. Diazinon 140-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 30888170-3 2019 Upon addition of AChE and acetylthiocholine (ATCh), the enzymatic hydrolysate (thiocholine) could seize Cu2+ from UCNPs-Cu2+ mixture, resulting in the quenched FL triggered on. Acetylthiocholine 45-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 30888170-3 2019 Upon addition of AChE and acetylthiocholine (ATCh), the enzymatic hydrolysate (thiocholine) could seize Cu2+ from UCNPs-Cu2+ mixture, resulting in the quenched FL triggered on. 5-(Acetylamino)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide 66-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 30888170-3 2019 Upon addition of AChE and acetylthiocholine (ATCh), the enzymatic hydrolysate (thiocholine) could seize Cu2+ from UCNPs-Cu2+ mixture, resulting in the quenched FL triggered on. cupric ion 104-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 30888170-3 2019 Upon addition of AChE and acetylthiocholine (ATCh), the enzymatic hydrolysate (thiocholine) could seize Cu2+ from UCNPs-Cu2+ mixture, resulting in the quenched FL triggered on. cupric ion 120-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 30888170-4 2019 OPs could irreversibly impede the activity of AChE, which caused the formation of thiocholine to decrease, thus, reduced the recovery of FL. Thiocholine 82-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 30959739-0 2019 In Vitro and In Silico Acetylcholinesterase Inhibitory Activity of Thalictricavine and Canadine and Their Predicted Penetration across the Blood-Brain Barrier. thalictricavine 67-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 30959739-0 2019 In Vitro and In Silico Acetylcholinesterase Inhibitory Activity of Thalictricavine and Canadine and Their Predicted Penetration across the Blood-Brain Barrier. canadine 87-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 30959739-2 2019 Inhibitory activities of (+)-thalictricavine (1) and (+)-canadine (2) on human acetylcholinesterase (hAChE) and butyrylcholinesterase (hBChE) were evaluated with the Ellman"s spectrophotometric method. thalictricavine 29-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 30959739-2 2019 Inhibitory activities of (+)-thalictricavine (1) and (+)-canadine (2) on human acetylcholinesterase (hAChE) and butyrylcholinesterase (hBChE) were evaluated with the Ellman"s spectrophotometric method. thalictricavine 29-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-106 30959739-2 2019 Inhibitory activities of (+)-thalictricavine (1) and (+)-canadine (2) on human acetylcholinesterase (hAChE) and butyrylcholinesterase (hBChE) were evaluated with the Ellman"s spectrophotometric method. canadine 57-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 30959739-2 2019 Inhibitory activities of (+)-thalictricavine (1) and (+)-canadine (2) on human acetylcholinesterase (hAChE) and butyrylcholinesterase (hBChE) were evaluated with the Ellman"s spectrophotometric method. canadine 57-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-106 30959739-6 2019 Furthermore, both alkaloids demonstrated a competitive-type pattern of hAChE inhibition and bind, most probably, in the same AChE sub-site as its substrate. Alkaloids 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-76 30959739-6 2019 Furthermore, both alkaloids demonstrated a competitive-type pattern of hAChE inhibition and bind, most probably, in the same AChE sub-site as its substrate. Alkaloids 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 30987121-5 2019 Two compounds, namely 11-O-(2-methylbenzoyl)-haemanthamine (1j) and 11-O-(4-nitrobenzoyl)-haemanthamine (1m), revealed the most intriguing profile, both being acetylcholinesterase (hAChE) inhibitors on a micromolar scale, with GSK-3beta inhibition properties, and predicted permeation through the BBB. 11-o-(2-methylbenzoyl)-haemanthamine 22-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-186 30987121-5 2019 Two compounds, namely 11-O-(2-methylbenzoyl)-haemanthamine (1j) and 11-O-(4-nitrobenzoyl)-haemanthamine (1m), revealed the most intriguing profile, both being acetylcholinesterase (hAChE) inhibitors on a micromolar scale, with GSK-3beta inhibition properties, and predicted permeation through the BBB. 11-o-(4-nitrobenzoyl)-haemanthamine 68-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-186 30622011-0 2019 Synthesis and biological evaluation of novel tris-chalcones as potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and alpha-glycosidase inhibitors. tris-chalcones 45-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 30622011-4 2019 These chalcone derivatives had Ki values in the range of 19.58-78.73 nM for hCA I, 12.23-41.70 nM for hCA II, 1.09-6.84 nM for AChE, 8.30-32.30 nM for BChE and 0.93 +- 0.20-18.53 +- 5.06 nM against alpha-glycosidase. Chalcone 6-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 30622011-5 2019 These results strongly support the promising nature of the tris-chalcone scaffold as selective carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase, and alpha-glycosidase inhibitor. tris-chalcone 59-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 30720917-5 2019 Among the synthesized compounds, 14-amino-13-(3-nitrophenyl)-2,3,4,13-tetrahydro-1H-benzo[6,7]chromeno[2,3-b]quinoline-7,12-dione (6m) depicted the best inhibitory activity toward acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50 s of 0.86 and 6.03 mum, respectively. 14-amino-13-(3-nitrophenyl)-2,3,4,13-tetrahydro-1h-benzo[6,7]chromeno[2,3-b]quinoline-7,12-dione 33-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-200 30720917-5 2019 Among the synthesized compounds, 14-amino-13-(3-nitrophenyl)-2,3,4,13-tetrahydro-1H-benzo[6,7]chromeno[2,3-b]quinoline-7,12-dione (6m) depicted the best inhibitory activity toward acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50 s of 0.86 and 6.03 mum, respectively. 14-amino-13-(3-nitrophenyl)-2,3,4,13-tetrahydro-1h-benzo[6,7]chromeno[2,3-b]quinoline-7,12-dione 33-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-206 30851693-2 2019 Based on the in vitro biological profile, compound S-K1035 was found to be the most potent inhibitor of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE), demonstrating balanced IC50 values of 6.3 and 9.1 nM, respectively. k1035 53-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-137 30851693-3 2019 For all the tacrine-tryptophan heterodimers, favorable inhibitory effect on hAChE as well as on hBChE was coined to the optimal spacer length ranging from five to eight carbon atoms between these two pharmacophores. Tacrine 12-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-81 30851693-3 2019 For all the tacrine-tryptophan heterodimers, favorable inhibitory effect on hAChE as well as on hBChE was coined to the optimal spacer length ranging from five to eight carbon atoms between these two pharmacophores. Tryptophan 20-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-81 30851693-3 2019 For all the tacrine-tryptophan heterodimers, favorable inhibitory effect on hAChE as well as on hBChE was coined to the optimal spacer length ranging from five to eight carbon atoms between these two pharmacophores. Carbon 169-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-81 30784883-2 2019 Herein, a series of N-benzylpiperidine analogs (17-31 and 32-46) were designed and synthesized as multi-functional inhibitors of acetylcholinesterase (AChE) and beta-secretase-1 (BACE-1) with moderate to excellent inhibitory activities. 1-benzylpiperidine 20-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-149 30784883-2 2019 Herein, a series of N-benzylpiperidine analogs (17-31 and 32-46) were designed and synthesized as multi-functional inhibitors of acetylcholinesterase (AChE) and beta-secretase-1 (BACE-1) with moderate to excellent inhibitory activities. 1-benzylpiperidine 20-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 30784883-5 2019 Meanwhile, both these compounds inhibited self- and AChE-induced Abeta aggregation in thioflavin T assay, which was also re-affirmed by morphological characterization of Abeta aggregates using atomic force microscopy (AFM). thioflavin T 86-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 29663860-0 2019 Novel coumarin derivatives as potent acetylcholinesterase inhibitors: insight into efficacy, mode and site of inhibition. coumarin 6-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 29663860-1 2019 The inhibitory efficacy of two substituted coumarin derivatives on the activity of neurodegenerative enzyme acetylcholinesterase (AChE) was assessed in aqueous buffer as well as in the presence of human serum albumin (HSA) and compared against standard cholinergic AD drug, Donepezil (DON). coumarin 43-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 29663860-1 2019 The inhibitory efficacy of two substituted coumarin derivatives on the activity of neurodegenerative enzyme acetylcholinesterase (AChE) was assessed in aqueous buffer as well as in the presence of human serum albumin (HSA) and compared against standard cholinergic AD drug, Donepezil (DON). coumarin 43-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 29663860-1 2019 The inhibitory efficacy of two substituted coumarin derivatives on the activity of neurodegenerative enzyme acetylcholinesterase (AChE) was assessed in aqueous buffer as well as in the presence of human serum albumin (HSA) and compared against standard cholinergic AD drug, Donepezil (DON). Donepezil 274-283 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 29663860-1 2019 The inhibitory efficacy of two substituted coumarin derivatives on the activity of neurodegenerative enzyme acetylcholinesterase (AChE) was assessed in aqueous buffer as well as in the presence of human serum albumin (HSA) and compared against standard cholinergic AD drug, Donepezil (DON). Donepezil 274-283 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 29663860-6 2019 Both the coumarin derivatives were observed to bind to the peripheral anionic site (PAS) of AChE and also found to displace the fluorescence marker thioflavinT (ThT) from AChE binding pocket. coumarin 9-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 29663860-6 2019 Both the coumarin derivatives were observed to bind to the peripheral anionic site (PAS) of AChE and also found to displace the fluorescence marker thioflavinT (ThT) from AChE binding pocket. coumarin 9-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 29663860-6 2019 Both the coumarin derivatives were observed to bind to the peripheral anionic site (PAS) of AChE and also found to displace the fluorescence marker thioflavinT (ThT) from AChE binding pocket. Aminosalicylic Acid 84-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 29663860-6 2019 Both the coumarin derivatives were observed to bind to the peripheral anionic site (PAS) of AChE and also found to displace the fluorescence marker thioflavinT (ThT) from AChE binding pocket. thioflavin T 148-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 29663860-6 2019 Both the coumarin derivatives were observed to bind to the peripheral anionic site (PAS) of AChE and also found to displace the fluorescence marker thioflavinT (ThT) from AChE binding pocket. thioflavin T 161-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 29695192-1 2019 Acetylcholinesterase is a critical enzyme that regulates neurotransmission by catalyzing the breakdown of neurotransmitter acetylcholine in synapses of the nervous system. Acetylcholine 123-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 29697300-0 2019 Cooperative hydrogen bonds and mobility of the non-aromatic ring as selectivity determinants for human acetylcholinesterase to similar anti-Alzheimer"s galantaminics: a computational study. Hydrogen 12-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 29697300-1 2019 Galantamine (Gnt) is a natural alkaloid inhibitor of acetylcholinesterase and is presently one of the most used drugs in the treatment against Alzheimer"s disease during both the initial and intermediate stages. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 29697300-1 2019 Galantamine (Gnt) is a natural alkaloid inhibitor of acetylcholinesterase and is presently one of the most used drugs in the treatment against Alzheimer"s disease during both the initial and intermediate stages. Galantamine 13-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 30902161-8 2019 Thus, current treatment options of AD include symptomatic treatment to elevate the levels of ACh by inhibiting AChE. Acetylcholine 93-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 30938485-3 2019 3D porous nanowire networks with surface functionalization of polydopamine make them a promising biocompatible microenvironment for immobilizing acetylcholinesterase (AChE) and constructing enzyme-based biosensors for sensitive detection of organophosphorus compounds. polydopamine 62-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 30938485-3 2019 3D porous nanowire networks with surface functionalization of polydopamine make them a promising biocompatible microenvironment for immobilizing acetylcholinesterase (AChE) and constructing enzyme-based biosensors for sensitive detection of organophosphorus compounds. polydopamine 62-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 30938485-3 2019 3D porous nanowire networks with surface functionalization of polydopamine make them a promising biocompatible microenvironment for immobilizing acetylcholinesterase (AChE) and constructing enzyme-based biosensors for sensitive detection of organophosphorus compounds. Organophosphorus Compounds 241-267 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 30938485-3 2019 3D porous nanowire networks with surface functionalization of polydopamine make them a promising biocompatible microenvironment for immobilizing acetylcholinesterase (AChE) and constructing enzyme-based biosensors for sensitive detection of organophosphorus compounds. Organophosphorus Compounds 241-267 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 30938485-4 2019 Taking advantage of their favorable structure and composition, the optimized product exhibits superior electrochemical activity toward thiocholine produced by AChE-catalyzed hydrolysis of acetylthiocholine. Thiocholine 135-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 30938485-4 2019 Taking advantage of their favorable structure and composition, the optimized product exhibits superior electrochemical activity toward thiocholine produced by AChE-catalyzed hydrolysis of acetylthiocholine. Acetylthiocholine 188-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 30938485-5 2019 Based on the inhibition of organophosphorus pesticide on the enzymatic activity of AChE, the inhibition mode for the detection of paraoxon-ethyl is established, displaying linear regions over the range of 0.5-1000 ng L-1 with a low detection limit of 0.185 ng L-1 . organophosphorus 27-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 30625376-0 2019 Use of high-throughput enzyme-based assay with xenobiotic metabolic capability to evaluate the inhibition of acetylcholinesterase activity by organophosphorous pesticides. organophosphorous 142-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-129 30625376-2 2019 The in vivo metabolites of some chemicals including organophosphorus pesticides can become more potent AChE inhibitors compared to their parental compounds. organophosphorus 52-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 30682493-0 2019 Oxidative stress induced by oxime reactivators of acetylcholinesterase in vitro. Oximes 28-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 30934674-0 2019 Novel Benzene-Based Carbamates for AChE/BChE Inhibition: Synthesis and Ligand/Structure-Oriented SAR Study. Benzene 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 30957826-1 2019 Herein, direct-laser-writing of TiO2-decorated graphene on indium-tin oxide glass was demonstrated to fabricate a unique photoelectrode with a rapid and stable photoelectrochemical response under visible light; this photoelectrode was then applied in a photoelectrochemical enzymatic biosensor for the sensitive detection of an acetylcholinesterase inhibitor. titanium dioxide 32-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 328-348 30957826-1 2019 Herein, direct-laser-writing of TiO2-decorated graphene on indium-tin oxide glass was demonstrated to fabricate a unique photoelectrode with a rapid and stable photoelectrochemical response under visible light; this photoelectrode was then applied in a photoelectrochemical enzymatic biosensor for the sensitive detection of an acetylcholinesterase inhibitor. Graphite 47-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 328-348 30957826-1 2019 Herein, direct-laser-writing of TiO2-decorated graphene on indium-tin oxide glass was demonstrated to fabricate a unique photoelectrode with a rapid and stable photoelectrochemical response under visible light; this photoelectrode was then applied in a photoelectrochemical enzymatic biosensor for the sensitive detection of an acetylcholinesterase inhibitor. indium tin oxide 59-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 328-348 30702092-0 2019 Metal coordination polymer induced perylene probe excimer fluorescence and its application in acetylcholinesterase sensing and alpha-fetoprotein immunoassay. Metals 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 30702092-0 2019 Metal coordination polymer induced perylene probe excimer fluorescence and its application in acetylcholinesterase sensing and alpha-fetoprotein immunoassay. Polymers 19-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 30702092-0 2019 Metal coordination polymer induced perylene probe excimer fluorescence and its application in acetylcholinesterase sensing and alpha-fetoprotein immunoassay. Perylene 35-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 30702092-1 2019 A novel sensing strategy for acetylcholinesterase (AChE) and alpha-fetoprotein (AFP) is developed, based on the perylene probe monomer to excimer fluorescence transformation induced by the in situ generation of a metal coordination polymer. Perylene 112-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 30702092-1 2019 A novel sensing strategy for acetylcholinesterase (AChE) and alpha-fetoprotein (AFP) is developed, based on the perylene probe monomer to excimer fluorescence transformation induced by the in situ generation of a metal coordination polymer. Perylene 112-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 30702092-1 2019 A novel sensing strategy for acetylcholinesterase (AChE) and alpha-fetoprotein (AFP) is developed, based on the perylene probe monomer to excimer fluorescence transformation induced by the in situ generation of a metal coordination polymer. Metals 213-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 30702092-1 2019 A novel sensing strategy for acetylcholinesterase (AChE) and alpha-fetoprotein (AFP) is developed, based on the perylene probe monomer to excimer fluorescence transformation induced by the in situ generation of a metal coordination polymer. Metals 213-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 30702092-2 2019 In the presence of AChE, acetylthiocholine chloride was hydrolyzed to thiocholine. Acetylthiocholine chloride 25-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 30702092-2 2019 In the presence of AChE, acetylthiocholine chloride was hydrolyzed to thiocholine. Thiocholine 31-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 30702092-10 2019 The hydrolysis of acetylthiocholine was catalyzed by AChE on the AuNPs, and the metal coordination polymer was then formed which resulted in the aggregation of the perylene probe and the formation of the excimer emission. Acetylthiocholine 18-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 30702092-10 2019 The hydrolysis of acetylthiocholine was catalyzed by AChE on the AuNPs, and the metal coordination polymer was then formed which resulted in the aggregation of the perylene probe and the formation of the excimer emission. Metals 80-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 30702092-10 2019 The hydrolysis of acetylthiocholine was catalyzed by AChE on the AuNPs, and the metal coordination polymer was then formed which resulted in the aggregation of the perylene probe and the formation of the excimer emission. Perylene 164-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 30934674-0 2019 Novel Benzene-Based Carbamates for AChE/BChE Inhibition: Synthesis and Ligand/Structure-Oriented SAR Study. Carbamates 20-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 30458057-0 2019 Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase. tabun 12-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 30458057-0 2019 Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase. Triazoles 40-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 30458057-0 2019 Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase. Oximes 59-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 30890752-2 2019 In addition, we determined the ability of MB-gCs to bind to the peripheral anionic site (PAS) of Electrophorus electricus AChE (EeAChE) and competitively displace propidium iodide from this site. Aminosalicylic Acid 89-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 30890752-6 2019 Molecular docking results showed that the MB-gCs could bind both to the catalytic active site and to the PAS of human AChE and BChE. Aminosalicylic Acid 105-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 30409660-0 2019 Determination of sinapine in rapeseed pomace extract: Its antioxidant and acetylcholinesterase inhibition properties. sinapine 17-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 30409660-6 2019 Furthermore, sinapine provided plasmid DNA (pBR322) protection, from 2,2"-azobis(2-amidinopropane) dihydrochloride and inhibited acetylcholinesterase activity by 85%. sinapine 13-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-149 30849129-2 2019 The acetylcholinesterase inhibitory activity of the essential oil of fresh leaves was investigated on silica gel plates. Oils, Volatile 52-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 30849129-2 2019 The acetylcholinesterase inhibitory activity of the essential oil of fresh leaves was investigated on silica gel plates. Silica Gel 102-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 30458057-1 2019 Acetylcholinesterase (AChE), an enzyme that degrades the neurotransmitter acetylcholine, when covalently inhibited by organophosphorus compounds (OPs), such as nerve agents and pesticides, can be reactivated by oximes. Acetylcholine 74-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 30458057-1 2019 Acetylcholinesterase (AChE), an enzyme that degrades the neurotransmitter acetylcholine, when covalently inhibited by organophosphorus compounds (OPs), such as nerve agents and pesticides, can be reactivated by oximes. Acetylcholine 74-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 30458057-1 2019 Acetylcholinesterase (AChE), an enzyme that degrades the neurotransmitter acetylcholine, when covalently inhibited by organophosphorus compounds (OPs), such as nerve agents and pesticides, can be reactivated by oximes. Organophosphorus Compounds 118-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 30458057-1 2019 Acetylcholinesterase (AChE), an enzyme that degrades the neurotransmitter acetylcholine, when covalently inhibited by organophosphorus compounds (OPs), such as nerve agents and pesticides, can be reactivated by oximes. Organophosphorus Compounds 118-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 30458057-1 2019 Acetylcholinesterase (AChE), an enzyme that degrades the neurotransmitter acetylcholine, when covalently inhibited by organophosphorus compounds (OPs), such as nerve agents and pesticides, can be reactivated by oximes. Organophosphorus Compounds 146-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 30458057-1 2019 Acetylcholinesterase (AChE), an enzyme that degrades the neurotransmitter acetylcholine, when covalently inhibited by organophosphorus compounds (OPs), such as nerve agents and pesticides, can be reactivated by oximes. Organophosphorus Compounds 146-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 30458057-1 2019 Acetylcholinesterase (AChE), an enzyme that degrades the neurotransmitter acetylcholine, when covalently inhibited by organophosphorus compounds (OPs), such as nerve agents and pesticides, can be reactivated by oximes. Oximes 211-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 30458057-1 2019 Acetylcholinesterase (AChE), an enzyme that degrades the neurotransmitter acetylcholine, when covalently inhibited by organophosphorus compounds (OPs), such as nerve agents and pesticides, can be reactivated by oximes. Oximes 211-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 30458057-5 2019 We identified several oximes with significantly improved in vitro reactivating potential for tabun-inhibited human AChE, and in vivo antidotal efficacies in tabun-exposed mice. Oximes 22-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 30458057-5 2019 We identified several oximes with significantly improved in vitro reactivating potential for tabun-inhibited human AChE, and in vivo antidotal efficacies in tabun-exposed mice. tabun 93-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 30605787-0 2019 Synthesis and bioactivities of pyrazoline benzensulfonamides as carbonic anhydrase and acetylcholinesterase inhibitors with low cytotoxicity. pyrazoline benzensulfonamides 31-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 30530106-2 2019 In the present study, 26 novel O-alkylcoumarin derivatives were synthesized and have been tested at 100 microM for their in vitro inhibitory potential against acetylcholinesterase (AChE) and butyrlcholinesterase (BChE) targets which are the key enzymes playing role in the pathogenesis of Alzheimer"s disease. o-alkylcoumarin 31-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 30530106-2 2019 In the present study, 26 novel O-alkylcoumarin derivatives were synthesized and have been tested at 100 microM for their in vitro inhibitory potential against acetylcholinesterase (AChE) and butyrlcholinesterase (BChE) targets which are the key enzymes playing role in the pathogenesis of Alzheimer"s disease. o-alkylcoumarin 31-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 30605787-3 2019 Inhibition potency of the sulfonamides were evaluated against human CA isoenzymes (hCA IandhCA II) and acetylcholinesterase (AChE) enzyme and also their cytotoxicities were investigated towards oral squamous cancer cell carcinoma (OSCC) cell lines (Ca9-22, HSC-2, HSC-3, and HSC-4) and non-tumor cells (HGF, HPLF, and HPC). Sulfonamides 26-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-137 30605787-5 2019 AChE enzyme was strongly inhibited by the sulfonamide derivatives with Ki values in the range of 37.7 +- 14.4-89.2 +- 30.2 nM The CC50 values of the compounds were found between 15 and 200 microM towards OSCC malign cell lines. Sulfonamides 42-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 30605787-8 2019 All sulfonamide derivatives studied here can be considered as good candidates to develop novel CAs or AChE inhibitor candidates based on the enzyme inhibition potencies with their low cytotoxicity and tumor selectivity. Sulfonamides 4-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 30610971-0 2019 One-pot four-component synthesis of thiazolidin-2-imines using CuI/ZnII dual catalysis: A new class of acetylcholinesterase inhibitors. thiazolidin-2-imines 36-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 30537031-0 2019 Synthesis and characterization of novel substituted thiophene derivatives and discovery of their carbonic anhydrase and acetylcholinesterase inhibition effects. Thiophenes 52-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 31162030-2 2019 OBJECTIVES: To investigate the in-situ expression of acetylcholinesterase (AChE) in the inflamed vessel wall of patients with biopsy-positive giant cell arteritis (GCA) as compared to biopsy-negative non-GCA patients, and to evaluate the in-vivo expression of AChE in patients with large-vessel GCA (LVGCA) by 11C-donepezil (AChE inhibitor) positron emission tomography/computed tomography (PET/CT). Donepezil C-11 310-323 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 31162030-2 2019 OBJECTIVES: To investigate the in-situ expression of acetylcholinesterase (AChE) in the inflamed vessel wall of patients with biopsy-positive giant cell arteritis (GCA) as compared to biopsy-negative non-GCA patients, and to evaluate the in-vivo expression of AChE in patients with large-vessel GCA (LVGCA) by 11C-donepezil (AChE inhibitor) positron emission tomography/computed tomography (PET/CT). Donepezil C-11 310-323 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 30537031-2 2019 These novel substituted thiophene derivatives were effective inhibitor compounds of the carbonic anhydrase I and II isozymes (hCA I and II), and acetylcholinesterase (AChE) enzyme with K i values in the range of 447.28 to 1004.65 nM for hCA I, 309.44 to 935.93 nM for hCA II, and 0.28 to 4.01 nM for AChE, respectively. Thiophenes 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 30537031-2 2019 These novel substituted thiophene derivatives were effective inhibitor compounds of the carbonic anhydrase I and II isozymes (hCA I and II), and acetylcholinesterase (AChE) enzyme with K i values in the range of 447.28 to 1004.65 nM for hCA I, 309.44 to 935.93 nM for hCA II, and 0.28 to 4.01 nM for AChE, respectively. Thiophenes 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 30537031-2 2019 These novel substituted thiophene derivatives were effective inhibitor compounds of the carbonic anhydrase I and II isozymes (hCA I and II), and acetylcholinesterase (AChE) enzyme with K i values in the range of 447.28 to 1004.65 nM for hCA I, 309.44 to 935.93 nM for hCA II, and 0.28 to 4.01 nM for AChE, respectively. Thiophenes 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 300-304 30537031-3 2019 Novel substituted thiophene derivatives can be good candidate drugs for the treatment of some diseases like neurological disorders, epilepsy, glaucoma, gastric and duodenal ulcers, mountain sickness, or osteoporosis as carbonic anhydrase isozymes inhibitors, and for the treatment of Alzheimer"s and Parkinson"s diseases as acetylcholinesterase inhibitors. Thiophenes 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 324-344 30746750-10 2019 It can be carefully stated that the molecule, MCULE-5872671137-0-1, which is chemically (3S)-N-{4-[(4-chlorophenyl)sulfanyl]phenyl}-3-hydroxypyrrolidine-1-carboxamide could function as a significant "seed" ligand for future design of potent AChE inhibitors and/or novel neuro drugs built upon the seed-scaffold. mcule 46-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 241-245 30944532-5 2019 However, the brain tissue AChE activity level in wild birds exposed to organophosphate (OP) pesticide was 48.0%-96.3% of that in the normal birds. Organophosphates 71-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 30539810-7 2019 Selected monoterpenoids from these essential oils are reported to inhibit acetylcholinesterase, both in vitro and in vivo. Monoterpenes 9-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 30539810-7 2019 Selected monoterpenoids from these essential oils are reported to inhibit acetylcholinesterase, both in vitro and in vivo. Oils, Volatile 35-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 30878086-8 2019 Furthermore, the moderate inhibitory activities of eugenol against mites P450 and AChE were demonstrated. Eugenol 51-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 30639387-3 2019 Inspired from "HDL bionics", we proposed biologically reassembled nanodrugs, donepezil-loaded apolipoprotein A-I-reconstituted HDL (rHDL/Do) that concurrently executed dual-missions of Abeta-targeting clearance and acetylcholinesterase (AChE) inhibition in AD therapy. Donepezil 77-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 237-241 30823444-0 2019 Drug-1,3,4-Thiadiazole Conjugates as Novel Mixed-Type Inhibitors of Acetylcholinesterase: Synthesis, Molecular Docking, Pharmacokinetics, and ADMET Evaluation. 1,3,4-thiadiazole 5-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 30823470-0 2019 Synthesis and AChE-Inhibitory Activity of New Benzimidazole Derivatives. benzimidazole 46-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 30823470-5 2019 Among them, compounds 3d and 3h, which featured 3,4-dihydroxy substitution at the phenyl ring and 5(6)-chloro substitution at the benzimidazole ring were found to be potent inhibitors of AChE. Tritium 29-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 30823470-5 2019 Among them, compounds 3d and 3h, which featured 3,4-dihydroxy substitution at the phenyl ring and 5(6)-chloro substitution at the benzimidazole ring were found to be potent inhibitors of AChE. benzimidazole 130-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 32255162-0 2019 Sensitive colorimetric sensor for point-of-care detection of acetylcholinesterase using cobalt oxyhydroxide nanoflakes. HCoO2 88-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 32255162-2 2019 Herein, we designed a colorimetric strategy for the facile and accurate detection of AChE based on tandem catalysis with a multi-enzyme system, which is constituted by cobalt oxyhydroxide nanoflakes (CoOOH NFs) and choline oxidase (CHO). HCoO2 168-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 32255162-2 2019 Herein, we designed a colorimetric strategy for the facile and accurate detection of AChE based on tandem catalysis with a multi-enzyme system, which is constituted by cobalt oxyhydroxide nanoflakes (CoOOH NFs) and choline oxidase (CHO). Choline 215-222 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 32255162-3 2019 In this sensor, AChE catalytically hydrolyzed acetylcholine (ACh) to produce choline, which was further efficiently oxidized by CHO to yield H2O2. Acetylcholine 46-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 32255162-3 2019 In this sensor, AChE catalytically hydrolyzed acetylcholine (ACh) to produce choline, which was further efficiently oxidized by CHO to yield H2O2. Choline 52-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 32255162-3 2019 In this sensor, AChE catalytically hydrolyzed acetylcholine (ACh) to produce choline, which was further efficiently oxidized by CHO to yield H2O2. Hydrogen Peroxide 141-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 32255162-5 2019 The resulting intensity could be employed as the signal output of the CHO/CoOOH/ACh system in monitoring AChE. coooh 74-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 32255162-5 2019 The resulting intensity could be employed as the signal output of the CHO/CoOOH/ACh system in monitoring AChE. Acetylcholine 80-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 30823604-1 2019 Acetylcholinesterase (AChE) catalyzes the hydrolysis of neurotransmitter acetylcholine to acetate and choline in a synaptic cleft. Acetylcholine 73-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 30823604-1 2019 Acetylcholinesterase (AChE) catalyzes the hydrolysis of neurotransmitter acetylcholine to acetate and choline in a synaptic cleft. Acetylcholine 73-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 30823604-1 2019 Acetylcholinesterase (AChE) catalyzes the hydrolysis of neurotransmitter acetylcholine to acetate and choline in a synaptic cleft. Acetates 90-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 30823604-1 2019 Acetylcholinesterase (AChE) catalyzes the hydrolysis of neurotransmitter acetylcholine to acetate and choline in a synaptic cleft. Acetates 90-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 30823604-1 2019 Acetylcholinesterase (AChE) catalyzes the hydrolysis of neurotransmitter acetylcholine to acetate and choline in a synaptic cleft. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 30529825-2 2019 The water extracts had the highest antioxidant activity, especially those from roots and flowers, and were further appraised for in vitro inhibition of enzymes implicated on the onset of human ailments, namely acetyl- (AChE) and butyrylcholinesterase (BuChE) for Alzheimer"s disease, alpha-glucosidase and alpha-amylase for diabetes, and tyrosinase for skin hyperpigmentation disorders. Water 4-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 219-223 30557782-5 2019 Moreover, the described biochips were successfully tested to detect acetylcholinesterase via catalytic reaction followed by the formation of fluoresceine as a product. Fluorescein 141-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 30384017-2 2019 Herein, a novel fluorometric assay based on the acetylcholinesterase (AChE) inhibited enzymatic activity and the new peroxidase-like Fe3O4 nanoparticles@ZIF-8 composite (Fe3O4 NPs@ZIF-8) was developed for the determination of OPs. ferryl iron 170-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 30384017-8 2019 However, due to the inhibition effect of OPs on the enzymatic activity of AChE, lower H2O2 amounts are produced in the presence of diazinon. Hydrogen Peroxide 86-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 30384017-8 2019 However, due to the inhibition effect of OPs on the enzymatic activity of AChE, lower H2O2 amounts are produced in the presence of diazinon. Diazinon 131-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 30956677-2 2019 Pharmacological researches have reported various benefits of verticine, including anticancer, anti-inflammatory, protecting against acute lung injury, tracheobronchial relaxation, antitussive, expectorant, sedative, and analgesic activities, in addition to inhibiting proliferation of cultured orbital fibroblast, angiotensin converting enzyme (ACE), and acetylcholinesterase (AChE) and inhibiting hERG potassium channels. verticine 61-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 355-375 30956677-2 2019 Pharmacological researches have reported various benefits of verticine, including anticancer, anti-inflammatory, protecting against acute lung injury, tracheobronchial relaxation, antitussive, expectorant, sedative, and analgesic activities, in addition to inhibiting proliferation of cultured orbital fibroblast, angiotensin converting enzyme (ACE), and acetylcholinesterase (AChE) and inhibiting hERG potassium channels. verticine 61-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 377-381 30785927-0 2019 Metal based donepezil analogues designed to inhibit human acetylcholinesterase for Alzheimer"s disease. Metals 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 30785927-0 2019 Metal based donepezil analogues designed to inhibit human acetylcholinesterase for Alzheimer"s disease. Donepezil 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 30785927-12 2019 These results further confirm the ability of metal-directed drugs to bind simultaneously to the active sites of AChE and support them as potential candidates for the future treatment of Alzheimer"s disease. Metals 45-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 30384017-2 2019 Herein, a novel fluorometric assay based on the acetylcholinesterase (AChE) inhibited enzymatic activity and the new peroxidase-like Fe3O4 nanoparticles@ZIF-8 composite (Fe3O4 NPs@ZIF-8) was developed for the determination of OPs. ferryl iron 133-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 30755593-5 2019 Molecular docking simulation of mixed-type and noncompetitive inhibitors for BACE1, AChE, and BChE indicated novel binding site-directed inhibition of the enzymes by pterosins and the structure-activity relationship. pterosin 166-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 30746750-10 2019 It can be carefully stated that the molecule, MCULE-5872671137-0-1, which is chemically (3S)-N-{4-[(4-chlorophenyl)sulfanyl]phenyl}-3-hydroxypyrrolidine-1-carboxamide could function as a significant "seed" ligand for future design of potent AChE inhibitors and/or novel neuro drugs built upon the seed-scaffold. (3s)-n-{4-[(4-chlorophenyl)sulfanyl]phenyl}-3-hydroxypyrrolidine-1-carboxamide 88-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 241-245 30673880-10 2019 There is a consensus on benefit of initiating any acetylcholinesterase inhibitor (ACHI: donepezil, rivastigmine, and galantamine) as a first line of treatment for psychosis in AD, as it may reduce and/or avoid the need for the use antipsychotics. achi 82-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 30694047-0 2019 A Luminescence Turn-On Assay for Acetylcholinesterase Activity and Inhibitor Screening Based on Supramolecular Self-Assembly of Alkynylplatinum(II) Complexes on Coordination Polymer. alkynylplatinum 128-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 30694047-1 2019 A new approach toward acetylcholinesterase (AChE) detection has been demonstrated based on the electrostatic interactions between anionic alkynylplatinum(II) complex molecules and cationic coordination polymer, together with the spectroscopic and emission characteristics of alkynylplatinum(II) complexes upon supramolecular self-assembly. alkynylplatinum(ii) 138-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 30694047-1 2019 A new approach toward acetylcholinesterase (AChE) detection has been demonstrated based on the electrostatic interactions between anionic alkynylplatinum(II) complex molecules and cationic coordination polymer, together with the spectroscopic and emission characteristics of alkynylplatinum(II) complexes upon supramolecular self-assembly. alkynylplatinum(ii) 138-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 30694047-1 2019 A new approach toward acetylcholinesterase (AChE) detection has been demonstrated based on the electrostatic interactions between anionic alkynylplatinum(II) complex molecules and cationic coordination polymer, together with the spectroscopic and emission characteristics of alkynylplatinum(II) complexes upon supramolecular self-assembly. Polymers 202-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 30694047-1 2019 A new approach toward acetylcholinesterase (AChE) detection has been demonstrated based on the electrostatic interactions between anionic alkynylplatinum(II) complex molecules and cationic coordination polymer, together with the spectroscopic and emission characteristics of alkynylplatinum(II) complexes upon supramolecular self-assembly. Polymers 202-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 30694047-1 2019 A new approach toward acetylcholinesterase (AChE) detection has been demonstrated based on the electrostatic interactions between anionic alkynylplatinum(II) complex molecules and cationic coordination polymer, together with the spectroscopic and emission characteristics of alkynylplatinum(II) complexes upon supramolecular self-assembly. alkynylplatinum(ii) 275-294 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 30694047-1 2019 A new approach toward acetylcholinesterase (AChE) detection has been demonstrated based on the electrostatic interactions between anionic alkynylplatinum(II) complex molecules and cationic coordination polymer, together with the spectroscopic and emission characteristics of alkynylplatinum(II) complexes upon supramolecular self-assembly. alkynylplatinum(ii) 275-294 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 30428418-5 2019 Acetylcholinesterase (AChE) is a member of the hydrolase protein super family and has a significant role in acetylcholine-mediated neurotransmission. Acetylcholine 108-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 30428418-5 2019 Acetylcholinesterase (AChE) is a member of the hydrolase protein super family and has a significant role in acetylcholine-mediated neurotransmission. Acetylcholine 108-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 30428418-6 2019 Here, we report the synthesis and determining of novel bis-thiomethylcyclohexanone compounds based hybrid scaffold of AChE inhibitors. bis-thiomethylcyclohexanone 55-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 30428418-7 2019 The newly synthesized bis-thiomethylcyclohexanone compounds showed Ki values of in range of 39.14-183.23 nM against human carbonic anhydrase I isoenzyme (hCA I), 46.03-194.02 nM against human carbonic anhydrase II isoenzyme (hCA II), 4.55-32.64 nM against AChE and 12.77-37.38 nM against butyrylcholinesterase (BChE). bis-thiomethylcyclohexanone 22-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 256-260 30431690-3 2019 In this study, the inhibition effects of chalcone and its epoxidated derivative chalcone epoxide against human carbonic anhydrase isozymes I and II (hCA I and hCA II), acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE) were evaluated. Chalcone 41-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-188 30431690-3 2019 In this study, the inhibition effects of chalcone and its epoxidated derivative chalcone epoxide against human carbonic anhydrase isozymes I and II (hCA I and hCA II), acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE) were evaluated. Chalcone 41-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 190-194 30431690-3 2019 In this study, the inhibition effects of chalcone and its epoxidated derivative chalcone epoxide against human carbonic anhydrase isozymes I and II (hCA I and hCA II), acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE) were evaluated. chalcone epoxide 80-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-188 30431690-3 2019 In this study, the inhibition effects of chalcone and its epoxidated derivative chalcone epoxide against human carbonic anhydrase isozymes I and II (hCA I and hCA II), acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE) were evaluated. chalcone epoxide 80-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 190-194 30431690-7 2019 Furthermore, chalcone epoxide was docked within the active sites of hCA I, hCA II, AChE, and BuChE to explore its binding mode with the enzymes. chalcone epoxide 13-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 30291908-1 2019 The neurotransmitter acetylcholine (ACh) acts as an autocrine growth factor for human lung cancer. Acetylcholine 21-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-39 30291908-2 2019 Several lines of evidence show that lung cancer cells express all of the proteins required for the uptake of choline (choline transporter 1, choline transporter-like proteins) synthesis of ACh (choline acetyltransferase, carnitine acetyltransferase), transport of ACh (vesicular acetylcholine transport, OCTs, OCTNs) and degradation of ACh (acetylcholinesterase, butyrylcholinesterase). Choline 109-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-192 30291908-2 2019 Several lines of evidence show that lung cancer cells express all of the proteins required for the uptake of choline (choline transporter 1, choline transporter-like proteins) synthesis of ACh (choline acetyltransferase, carnitine acetyltransferase), transport of ACh (vesicular acetylcholine transport, OCTs, OCTNs) and degradation of ACh (acetylcholinesterase, butyrylcholinesterase). Choline 109-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 264-267 30291908-2 2019 Several lines of evidence show that lung cancer cells express all of the proteins required for the uptake of choline (choline transporter 1, choline transporter-like proteins) synthesis of ACh (choline acetyltransferase, carnitine acetyltransferase), transport of ACh (vesicular acetylcholine transport, OCTs, OCTNs) and degradation of ACh (acetylcholinesterase, butyrylcholinesterase). Choline 109-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 264-267 30291908-2 2019 Several lines of evidence show that lung cancer cells express all of the proteins required for the uptake of choline (choline transporter 1, choline transporter-like proteins) synthesis of ACh (choline acetyltransferase, carnitine acetyltransferase), transport of ACh (vesicular acetylcholine transport, OCTs, OCTNs) and degradation of ACh (acetylcholinesterase, butyrylcholinesterase). Choline 109-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 341-361 30291908-2 2019 Several lines of evidence show that lung cancer cells express all of the proteins required for the uptake of choline (choline transporter 1, choline transporter-like proteins) synthesis of ACh (choline acetyltransferase, carnitine acetyltransferase), transport of ACh (vesicular acetylcholine transport, OCTs, OCTNs) and degradation of ACh (acetylcholinesterase, butyrylcholinesterase). maxacalcitol 304-308 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-192 30700752-4 2019 Imidazo[1,2-a]pyridine-based derivatives with biphenyl side chain are potential AChE inhibitors. imidazo(1,2-a)pyridine 0-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 30700752-5 2019 Compound 2h which bears a biphenyl side chain and methyl substituent at the position R4 of the imidazo[1,2-a]pyridine ring showed the strongest AChE inhibition with an IC50 value of 79 microM. Deuterium 9-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 30700752-5 2019 Compound 2h which bears a biphenyl side chain and methyl substituent at the position R4 of the imidazo[1,2-a]pyridine ring showed the strongest AChE inhibition with an IC50 value of 79 microM. imidazo(1,2-a)pyridine 95-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 30565170-3 2019 Based on this discovery, a highly sensitive detection of acetylthiocholine (ATCl) was achieved using the acetylcholinesterase (AChE) biosensor. Acetylthiocholine 57-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 30565170-3 2019 Based on this discovery, a highly sensitive detection of acetylthiocholine (ATCl) was achieved using the acetylcholinesterase (AChE) biosensor. Acetylthiocholine 57-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 30565170-3 2019 Based on this discovery, a highly sensitive detection of acetylthiocholine (ATCl) was achieved using the acetylcholinesterase (AChE) biosensor. Acetylthiocholine 76-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 30565170-3 2019 Based on this discovery, a highly sensitive detection of acetylthiocholine (ATCl) was achieved using the acetylcholinesterase (AChE) biosensor. Acetylthiocholine 76-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 30565170-5 2019 ATCl was catalyzed by acetylcholinesterase (AChE) to produce thiocholine, which served as the coreactant accelerator to improve the ECL signal of Au NC-S2O82- system. Acetylthiocholine 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 30565170-5 2019 ATCl was catalyzed by acetylcholinesterase (AChE) to produce thiocholine, which served as the coreactant accelerator to improve the ECL signal of Au NC-S2O82- system. Acetylthiocholine 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 30565170-5 2019 ATCl was catalyzed by acetylcholinesterase (AChE) to produce thiocholine, which served as the coreactant accelerator to improve the ECL signal of Au NC-S2O82- system. Thiocholine 61-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 30565170-5 2019 ATCl was catalyzed by acetylcholinesterase (AChE) to produce thiocholine, which served as the coreactant accelerator to improve the ECL signal of Au NC-S2O82- system. Thiocholine 61-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 30503937-0 2019 Design and development of some phenyl benzoxazole derivatives as a potent acetylcholinesterase inhibitor with antioxidant property to enhance learning and memory. phenyl benzoxazole 31-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 30503937-2 2019 The synthesized phenyl benzoxazole derivatives exhibited significant antioxidant potential and AChE inhibitory activity, whereas the antioxidant potential of compound 34 (49.6%) was observed significantly better than standard donepezil (<10%) and parallel to ascorbic acid (56.6%). phenyl benzoxazole 16-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 30378536-1 2019 OBJECTIVE: Donepezil is an acetylcholinesterase inhibitor (AChI) that improves cognitive function in Alzheimer"s disease (AD) patients. Donepezil 11-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 29322868-0 2019 In silico approaches to evaluate the molecular properties of organophosphate compounds to inhibit acetylcholinesterase activity in housefly. Organophosphates 61-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-118 30499458-0 2019 Amorphous metal boride as a novel platform for acetylcholinesterase biosensor development and detection of organophosphate pesticides. metal boride 10-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 30499458-0 2019 Amorphous metal boride as a novel platform for acetylcholinesterase biosensor development and detection of organophosphate pesticides. Organophosphates 107-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 30499458-2 2019 Herein, we demonstrated that amorphous bimetallic boride material (Co-2Ni-B) prepared by a simple and facile aqueous reaction is an efficient matrix to immobilize acetylcholinesterase (AChE) to construct a biosensor for the determination of organophosphate pesticides. bimetallic boride 39-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-183 30499458-2 2019 Herein, we demonstrated that amorphous bimetallic boride material (Co-2Ni-B) prepared by a simple and facile aqueous reaction is an efficient matrix to immobilize acetylcholinesterase (AChE) to construct a biosensor for the determination of organophosphate pesticides. bimetallic boride 39-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 185-189 30499458-2 2019 Herein, we demonstrated that amorphous bimetallic boride material (Co-2Ni-B) prepared by a simple and facile aqueous reaction is an efficient matrix to immobilize acetylcholinesterase (AChE) to construct a biosensor for the determination of organophosphate pesticides. Organophosphates 241-256 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-183 30499458-2 2019 Herein, we demonstrated that amorphous bimetallic boride material (Co-2Ni-B) prepared by a simple and facile aqueous reaction is an efficient matrix to immobilize acetylcholinesterase (AChE) to construct a biosensor for the determination of organophosphate pesticides. Organophosphates 241-256 acetylcholinesterase (Cartwright blood group) Homo sapiens 185-189 30673880-10 2019 There is a consensus on benefit of initiating any acetylcholinesterase inhibitor (ACHI: donepezil, rivastigmine, and galantamine) as a first line of treatment for psychosis in AD, as it may reduce and/or avoid the need for the use antipsychotics. Donepezil 88-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 30673880-10 2019 There is a consensus on benefit of initiating any acetylcholinesterase inhibitor (ACHI: donepezil, rivastigmine, and galantamine) as a first line of treatment for psychosis in AD, as it may reduce and/or avoid the need for the use antipsychotics. Rivastigmine 99-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 30673880-10 2019 There is a consensus on benefit of initiating any acetylcholinesterase inhibitor (ACHI: donepezil, rivastigmine, and galantamine) as a first line of treatment for psychosis in AD, as it may reduce and/or avoid the need for the use antipsychotics. Galantamine 117-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 30296051-0 2019 4,6-Diphenylpyrimidine Derivatives as Dual Inhibitors of Monoamine Oxidase and Acetylcholinesterase for the Treatment of Alzheimer"s Disease. 4,6-diphenylpyrimidine 0-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-99 30296051-3 2019 A total of 15 new propargyl containing 4,6-diphenylpyrimidine derivatives were synthesized and screened for the MAO and AChE inhibition activities along with ROS production inhibition and metal-chelation potential. propargyl 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 30296051-3 2019 A total of 15 new propargyl containing 4,6-diphenylpyrimidine derivatives were synthesized and screened for the MAO and AChE inhibition activities along with ROS production inhibition and metal-chelation potential. 4,6-diphenylpyrimidine 39-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 30296051-13 2019 Thus, 4,6-diphenylpyrimidine derivatives can act as promising leads in the development of dual-acting inhibitors targeting MAO-A and AChE enzymes for the treatment of Alzheimer"s disease. 4,6-diphenylpyrimidine 6-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 30372021-4 2019 This review is focused on donepezil and covers the background, synthetic routes, structure-activity relationships, binding interactions with acetylcholinesterase, pharmacokinetics and metabolism, efficacy, adverse effects, and historical importance of this leading therapeutic in the treatment of Alzheimer"s disease and true Classic in Chemical Neuroscience. Donepezil 26-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 30236704-6 2019 Irradiated TCPF and EC are more potent AChE inhibitors than irradiated EW. tcpf 11-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 30236704-6 2019 Irradiated TCPF and EC are more potent AChE inhibitors than irradiated EW. ec 20-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 30626059-4 2019 This study aimed to examine whether BPA exposure is associated with the hydroxymethylation level of the sperm ACHE gene. bisphenol A 36-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 30291908-2 2019 Several lines of evidence show that lung cancer cells express all of the proteins required for the uptake of choline (choline transporter 1, choline transporter-like proteins) synthesis of ACh (choline acetyltransferase, carnitine acetyltransferase), transport of ACh (vesicular acetylcholine transport, OCTs, OCTNs) and degradation of ACh (acetylcholinesterase, butyrylcholinesterase). octns 310-315 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-192 30463700-4 2019 These two factors i.e. high salt concentration in the bulk medium and less viscous membranes, allow a deeper insertion of the EGCG into the lipid bilayer, thus leading to a greater inhibition of AChE. Salts 28-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 30463700-4 2019 These two factors i.e. high salt concentration in the bulk medium and less viscous membranes, allow a deeper insertion of the EGCG into the lipid bilayer, thus leading to a greater inhibition of AChE. epigallocatechin gallate 126-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 30463700-5 2019 As a corollary, we propose that any treatment or process that leads to a slight decrease in cholesterol content in the membranes can efficiently enhance the inhibitory activity of EGCG, which can have important consequences in all the pathologies where the inhibition of AChE is recommended. Cholesterol 92-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 271-275 30463700-5 2019 As a corollary, we propose that any treatment or process that leads to a slight decrease in cholesterol content in the membranes can efficiently enhance the inhibitory activity of EGCG, which can have important consequences in all the pathologies where the inhibition of AChE is recommended. epigallocatechin gallate 180-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 271-275 31550216-2 2019 OBJECTIVES: A previously synthesized ethyl acetohydroxamate-chalcones (L1-L22) were studied for their inhibitory activities against human recombinant monoamine oxidase A and B (hMAO-A and hMAO-B, respectively) and acetylcholinesterase (AChE) as multi-target directed ligands for the treatment of Alzheimer"s disease (AD). Chalcones 37-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-234 31550216-2 2019 OBJECTIVES: A previously synthesized ethyl acetohydroxamate-chalcones (L1-L22) were studied for their inhibitory activities against human recombinant monoamine oxidase A and B (hMAO-A and hMAO-B, respectively) and acetylcholinesterase (AChE) as multi-target directed ligands for the treatment of Alzheimer"s disease (AD). Chalcones 37-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 236-240 31550216-10 2019 Moerover, chalcones L3, L4, L9, L11, and L12 showed potential AChE inhibitory effect with IC50 values 0.67, 0.85, 0.39, 0.30, and 0.45 muM, respectively. Chalcones 10-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 30230960-3 2019 Variability between organophosphorus insecticides-in lipophilicity, speed of activation, speed and potency of acetylcholinesterase inhibition, and in the chemical groups attached to the phosphorus-results in variable speed of poisoning onset, severity, clinical toxidrome, and case fatality. organophosphorus 20-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 30230960-3 2019 Variability between organophosphorus insecticides-in lipophilicity, speed of activation, speed and potency of acetylcholinesterase inhibition, and in the chemical groups attached to the phosphorus-results in variable speed of poisoning onset, severity, clinical toxidrome, and case fatality. Phosphorus 26-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 30621344-0 2019 Synthesis of diN-Substituted Glycyl-Phenylalanine Derivatives by Using Ugi Four Component Reaction and Their Potential as Acetylcholinesterase Inhibitors. din-substituted glycyl-phenylalanine 13-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 30621344-5 2019 Experimentally, all of the synthesized diNsGF derivatives showed moderate inhibitory activities against acetylcholinesterase (AChE) and poor activities against butyrylcholinesterase (BuChE). dinsgf 39-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 30621344-5 2019 Experimentally, all of the synthesized diNsGF derivatives showed moderate inhibitory activities against acetylcholinesterase (AChE) and poor activities against butyrylcholinesterase (BuChE). dinsgf 39-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 30621344-7 2019 Molecular docking experiments of diNsGF derivatives inside AChE suggest that these compounds placed the phenylalanine group at the peripheral site of AChE. dinsgf 33-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 30621344-7 2019 Molecular docking experiments of diNsGF derivatives inside AChE suggest that these compounds placed the phenylalanine group at the peripheral site of AChE. dinsgf 33-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 30621344-7 2019 Molecular docking experiments of diNsGF derivatives inside AChE suggest that these compounds placed the phenylalanine group at the peripheral site of AChE. Phenylalanine 104-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 30621344-7 2019 Molecular docking experiments of diNsGF derivatives inside AChE suggest that these compounds placed the phenylalanine group at the peripheral site of AChE. Phenylalanine 104-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 30118774-7 2019 Bergenin demonstrated dose-dependent inhibition of both AChE and BuChE in vitro and found to be safe up to 50 muM when screened in vitro on SH-SY5Y cell lines by cytotoxicity studies using MTT and Alamar blue assays. bergenin 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 31334039-0 2019 Therapeutic potency of substituted chromones as Alzheimer"s drug: Elucidation of acetylcholinesterase inhibitory activity through spectroscopic and molecular modelling investigation. Chromones 35-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 31334039-1 2019 Introduction: Documentation on the potency of chromones as acetylcholinesterase (AChE) antagonists has paved the way for the design and usage of new chromone analogues as inhibitors of AChE modelled on the hypothesis based on cholinergic pathway of Alzheimer"s disease (AD). Chromones 47-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 31334039-1 2019 Introduction: Documentation on the potency of chromones as acetylcholinesterase (AChE) antagonists has paved the way for the design and usage of new chromone analogues as inhibitors of AChE modelled on the hypothesis based on cholinergic pathway of Alzheimer"s disease (AD). Chromones 47-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 31334039-1 2019 Introduction: Documentation on the potency of chromones as acetylcholinesterase (AChE) antagonists has paved the way for the design and usage of new chromone analogues as inhibitors of AChE modelled on the hypothesis based on cholinergic pathway of Alzheimer"s disease (AD). Chromones 47-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 31334039-1 2019 Introduction: Documentation on the potency of chromones as acetylcholinesterase (AChE) antagonists has paved the way for the design and usage of new chromone analogues as inhibitors of AChE modelled on the hypothesis based on cholinergic pathway of Alzheimer"s disease (AD). Chromones 47-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 31334039-1 2019 Introduction: Documentation on the potency of chromones as acetylcholinesterase (AChE) antagonists has paved the way for the design and usage of new chromone analogues as inhibitors of AChE modelled on the hypothesis based on cholinergic pathway of Alzheimer"s disease (AD). Chromones 47-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 31334039-1 2019 Introduction: Documentation on the potency of chromones as acetylcholinesterase (AChE) antagonists has paved the way for the design and usage of new chromone analogues as inhibitors of AChE modelled on the hypothesis based on cholinergic pathway of Alzheimer"s disease (AD). Chromones 47-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 31334039-4 2019 Results: The investigated systems exhibited strong inhibition activities against AChE, with CyC (IC50= 85.12 +- 6.70 nM) acting as better inhibitor than AMC (IC50 = 103.09 +- 11.90 nM) and both having IC50 values in the range of FDA approved cholinergic drug Donepezil (IC50 = 74.13 +- 8.30 nM). 7-amino-4-methylcoumarin 153-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 31334039-4 2019 Results: The investigated systems exhibited strong inhibition activities against AChE, with CyC (IC50= 85.12 +- 6.70 nM) acting as better inhibitor than AMC (IC50 = 103.09 +- 11.90 nM) and both having IC50 values in the range of FDA approved cholinergic drug Donepezil (IC50 = 74.13 +- 8.30 nM). Donepezil 259-268 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 30793620-5 2019 Inhibitory effect of THDOC on hydrolytic activity of AChE was confirmed by in vitro assay (IC50 = 5.68 microM). tetrahydrodeoxycorticosterone 21-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 30543170-5 2019 RESULTS: Based on in-silico AChE interaction studies, we predicted quercetin, caffeine, ascorbic acid and gallic acid to be potential AChE inhibitors. Quercetin 67-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 30543170-5 2019 RESULTS: Based on in-silico AChE interaction studies, we predicted quercetin, caffeine, ascorbic acid and gallic acid to be potential AChE inhibitors. Quercetin 67-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 30543170-5 2019 RESULTS: Based on in-silico AChE interaction studies, we predicted quercetin, caffeine, ascorbic acid and gallic acid to be potential AChE inhibitors. Caffeine 78-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 30543170-5 2019 RESULTS: Based on in-silico AChE interaction studies, we predicted quercetin, caffeine, ascorbic acid and gallic acid to be potential AChE inhibitors. Caffeine 78-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 30543170-5 2019 RESULTS: Based on in-silico AChE interaction studies, we predicted quercetin, caffeine, ascorbic acid and gallic acid to be potential AChE inhibitors. Ascorbic Acid 88-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 30543170-5 2019 RESULTS: Based on in-silico AChE interaction studies, we predicted quercetin, caffeine, ascorbic acid and gallic acid to be potential AChE inhibitors. Ascorbic Acid 88-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 30543170-5 2019 RESULTS: Based on in-silico AChE interaction studies, we predicted quercetin, caffeine, ascorbic acid and gallic acid to be potential AChE inhibitors. Gallic Acid 106-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 30543170-5 2019 RESULTS: Based on in-silico AChE interaction studies, we predicted quercetin, caffeine, ascorbic acid and gallic acid to be potential AChE inhibitors. Gallic Acid 106-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 31660828-8 2019 RESULTS: For the first time, new inhibitors were identified, namely: methyl jasmonate, 1R-(-)- nopol ((anti-acetyl-(AChE) and butyrylcholinesterase (BChE) activity)) and 1,4-cineole, allo- aromadendrene, nerolidol, beta-ionone, and (R)-(+)-pulegone (anti-BChE activity). nopol benzyl ether 87-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 30101703-5 2019 Plant derived licensed drugs, Galantamine and Huperzine-A were studied extensively due to their AChE inhibitory action for mild to moderate cases of AD. Galantamine 30-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 30101703-5 2019 Plant derived licensed drugs, Galantamine and Huperzine-A were studied extensively due to their AChE inhibitory action for mild to moderate cases of AD. huperzine A 46-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 29768996-5 2019 Donepezil was able to ameliorate the symptoms related to AD mainly via AChE, but also through reduction of beta-amyloid burden. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 30706815-2 2019 The enzyme Acetylcholinesterase Enzyme (AChE) is the key enzyme in the hydrolysis of the neurotransmitter acetylcholine and is also the target of most of the clinically used drugs for the treatment of AD but these drugs provide only symptomatic treatment and have the limitation of loss of therapeutic efficacy with time. Acetylcholine 106-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-38 30706815-2 2019 The enzyme Acetylcholinesterase Enzyme (AChE) is the key enzyme in the hydrolysis of the neurotransmitter acetylcholine and is also the target of most of the clinically used drugs for the treatment of AD but these drugs provide only symptomatic treatment and have the limitation of loss of therapeutic efficacy with time. Acetylcholine 106-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 30366255-1 2019 Herein we envisaged the possibility of exploiting alkyl nitrates as precursors of alcohol-bearing dual inhibitors targeting acetylcholinesterase (AChE) and monoamine oxidase B (MAO B), key enzymes in neurodegenerative syndromes such as Alzheimer"s disease (AD), through biotransformation unmasking an alcoholic function upon nitric oxide (NO) release. alkyl nitrates 50-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 30366255-1 2019 Herein we envisaged the possibility of exploiting alkyl nitrates as precursors of alcohol-bearing dual inhibitors targeting acetylcholinesterase (AChE) and monoamine oxidase B (MAO B), key enzymes in neurodegenerative syndromes such as Alzheimer"s disease (AD), through biotransformation unmasking an alcoholic function upon nitric oxide (NO) release. Alcohols 82-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 30366255-1 2019 Herein we envisaged the possibility of exploiting alkyl nitrates as precursors of alcohol-bearing dual inhibitors targeting acetylcholinesterase (AChE) and monoamine oxidase B (MAO B), key enzymes in neurodegenerative syndromes such as Alzheimer"s disease (AD), through biotransformation unmasking an alcoholic function upon nitric oxide (NO) release. Nitric Oxide 325-337 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 30366255-4 2019 Nitrate 14 proved to be a brain permeant, potent AChE-MAO B inhibitor by itself. nitrate 14 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 30819076-10 2019 RESULTS: A novel molecule formed by combination of 6-chlorotacrine and memantine proved to be a promising multipotent hybrid capable of blocking the action of AChE as well as NMDARs. 6-chlorotacrine 51-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 30626059-7 2019 Sperm ACHE hydroxymethylation level was higher in the BPA exposure group (p = 0.041) compared to the control group. bisphenol A 54-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 30626059-8 2019 When subjects were categorized according to tertiles of detected BPA level, higher ACHE hydroxymethylation levels were observed for the lowest, middle, and top tertiles compared to those with BPA below the limit of detection (LOD). bisphenol A 65-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 30819076-10 2019 RESULTS: A novel molecule formed by combination of 6-chlorotacrine and memantine proved to be a promising multipotent hybrid capable of blocking the action of AChE as well as NMDARs. Memantine 71-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 30626059-9 2019 In a linear regression analysis adjusted for confounders, a positive linear association between urine BPA concentration and 5-hydroxymethylcytosine (5hmC) rate of the sperm ACHE gene was observed, although the association did not reach statistical significance in all categories after being stratified by the BPA tertile. bisphenol A 102-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-177 30819076-11 2019 The presented hybrid surpassed the AChE inhibitory activity of the parent compound 6-Cl-THA twofold. 6-cl-tha 83-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 30626059-9 2019 In a linear regression analysis adjusted for confounders, a positive linear association between urine BPA concentration and 5-hydroxymethylcytosine (5hmC) rate of the sperm ACHE gene was observed, although the association did not reach statistical significance in all categories after being stratified by the BPA tertile. 5-hydroxymethylcytosine 124-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-177 30819076-12 2019 According to results it has been revealed that our novel hybrid blocks NMDARs in the same manner as memantine, potently inhibits AChE and is predicted to cross the blood-brain barrier via passive diffusion. Memantine 100-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 30819078-4 2019 Donepezil is one of the currently approved drugs for AD therapy acting as an acetylcholinesterase inhibitor. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 30626059-9 2019 In a linear regression analysis adjusted for confounders, a positive linear association between urine BPA concentration and 5-hydroxymethylcytosine (5hmC) rate of the sperm ACHE gene was observed, although the association did not reach statistical significance in all categories after being stratified by the BPA tertile. 5-hydroxymethylcytosine 149-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-177 30819081-1 2019 BACKGROUND: Although no effective treatment for the Alzheimer"s disease currently exist, some drugs acting as Acetylcholinesterase inhibitors, like galanthamine have positively affected such patients. Galantamine 148-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 30626059-9 2019 In a linear regression analysis adjusted for confounders, a positive linear association between urine BPA concentration and 5-hydroxymethylcytosine (5hmC) rate of the sperm ACHE gene was observed, although the association did not reach statistical significance in all categories after being stratified by the BPA tertile. bisphenol A 309-312 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-177 30819081-3 2019 Here we report synthesis of new peptide-galanthamine derivatives, with expected inhibitory activity against both Acetylcholinesterase and beta-secretase. peptide-galanthamine 32-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-133 30626059-10 2019 In conclusion, 5hmC of the sperm ACHE gene was positively associated with BPA exposure, which may provide supportive evidence for BPA"s effects on male fertility or other health endpoints. 5-hydroxymethylcytosine 15-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 30626059-10 2019 In conclusion, 5hmC of the sperm ACHE gene was positively associated with BPA exposure, which may provide supportive evidence for BPA"s effects on male fertility or other health endpoints. bisphenol A 74-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 30626059-10 2019 In conclusion, 5hmC of the sperm ACHE gene was positively associated with BPA exposure, which may provide supportive evidence for BPA"s effects on male fertility or other health endpoints. bisphenol A 130-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 31089376-5 2019 Acetylcholinesterase (AChE) inhibition by the essential oil was examined using Ellman"s method. Oils, Volatile 46-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 30478812-9 2019 Neostigmine significantly enhanced EFS responses, confirming its selectivity for inhibiting acetylcholinesterase which is responsible for termination of acetylcholine. Neostigmine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 31089376-5 2019 Acetylcholinesterase (AChE) inhibition by the essential oil was examined using Ellman"s method. Oils, Volatile 46-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 31089376-10 2019 O. decumbens essential oil was considerably inhibitory to acetylcholinesterase activity (IC50 = 0.117 microg/mL). Oils, Volatile 13-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 30027640-2 2019 Organophosphorus compounds (OPCs), inhibitors of acetylcholinesterase (AChE), are useful agents as pesticides, but also represent a serious health hazard. Organophosphorus Compounds 28-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 30027640-2 2019 Organophosphorus compounds (OPCs), inhibitors of acetylcholinesterase (AChE), are useful agents as pesticides, but also represent a serious health hazard. Organophosphorus Compounds 28-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 30411689-0 2019 Spirocyclohexadienones as an Uncommon Scaffold for Acetylcholinesterase Inhibitory Activity. spirocyclohexadienones 0-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 30027640-2 2019 Organophosphorus compounds (OPCs), inhibitors of acetylcholinesterase (AChE), are useful agents as pesticides, but also represent a serious health hazard. Organophosphorus Compounds 0-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 30027640-2 2019 Organophosphorus compounds (OPCs), inhibitors of acetylcholinesterase (AChE), are useful agents as pesticides, but also represent a serious health hazard. Organophosphorus Compounds 0-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 30411689-5 2019 METHODS: The objective of this work is to identify new substances that have spatial structural similarity with donepezil, an efficient commercial drug used for the treatment of Alzheimer"s disease, and to evaluate the capacity of inhibition of these new substances against the enzyme acetylcholinesterase. Donepezil 111-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 284-304 30411689-9 2019 Molecular docking study indicated that the spirocyclohexadienone, 9e (IC50 = 0.12 microM), a mixedtype AChE inhibitor, showed a good interaction at active site of the enzyme, including the cationic (CAS) and the peripheral site (PAS). spirocyclohexadienone 43-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 30411689-9 2019 Molecular docking study indicated that the spirocyclohexadienone, 9e (IC50 = 0.12 microM), a mixedtype AChE inhibitor, showed a good interaction at active site of the enzyme, including the cationic (CAS) and the peripheral site (PAS). Calcium 199-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 30411689-9 2019 Molecular docking study indicated that the spirocyclohexadienone, 9e (IC50 = 0.12 microM), a mixedtype AChE inhibitor, showed a good interaction at active site of the enzyme, including the cationic (CAS) and the peripheral site (PAS). Aminosalicylic Acid 229-232 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 30411689-10 2019 CONCLUSION: We described the first study aimed at investigating the biological properties of spirocyclohexadienones as acetylcholinesterase inhibitors. spirocyclohexadienones 93-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 31315114-2 2019 To further optimize treatment, acetylcholinesterase inhibitors such as donepezil and galantamine have gained increased interest, though with conflicting results. Donepezil 71-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 31538893-2 2019 Based on the cholinergic hypothesis, and Xray crystallographic determination of the structure of acetylcholinesterase (AChE) enzyme, the level of acetylcholine (ACh, an important neurotransmitter associated with memory) in the hippocampus and cortex area of the brain has a direct effect on Alzheimer. Acetylcholine 97-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 31538893-2 2019 Based on the cholinergic hypothesis, and Xray crystallographic determination of the structure of acetylcholinesterase (AChE) enzyme, the level of acetylcholine (ACh, an important neurotransmitter associated with memory) in the hippocampus and cortex area of the brain has a direct effect on Alzheimer. Acetylcholine 119-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 31538893-3 2019 This fact encourages scientists to design and synthesize a wide range of acetylcholinesterase inhibitors (AChEIs) to control the level of ACh in the brain, keeping in view the crystallographic structure of AChE enzyme and drugs approved by the Food and Drug Administration (FDA). Acetylcholine 106-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 31315114-2 2019 To further optimize treatment, acetylcholinesterase inhibitors such as donepezil and galantamine have gained increased interest, though with conflicting results. Galantamine 85-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 30380560-7 2019 The acetylcholinesterase inhibitor, neostigmine (NEO; 0.5 mumol/L), also decreased transmitter exocytosis. Neostigmine 36-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 31067549-9 2019 CONCLUSION: Aripiprazole may cause EPS at clinical dosages by augmenting cholinergic effects via AChE inhibition, in addition to its suppressive effect on dopaminergic neurons. Aripiprazole 12-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 31679283-3 2019 We previously reported the AChE-inhibitory and antioxidant-mediated antiamnestic effects of a hydromethanol extract from Ganoderma mediosinense (HME), which we evaluated using in vitro and in vivo models. hydromethanol 94-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 31679283-3 2019 We previously reported the AChE-inhibitory and antioxidant-mediated antiamnestic effects of a hydromethanol extract from Ganoderma mediosinense (HME), which we evaluated using in vitro and in vivo models. ganoderma mediosinense 121-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 31679283-8 2019 Among the fractions, the ethyl acetate fraction showed appreciable AChE-inhibitory (half-maximal inhibitory concentration [IC50] 0.81 +- 0.04 mg/mL) and DPPH scavenging (IC50 2.04 +- 0.77 mug/mL) activities; therefore it was subjected to flash chromatography, which separated 9 subfractions. ethyl acetate 25-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 31679283-12 2019 This study shows that gallic acid, a well-recognized phenolic acid, is responsible for the AChE-inhibitory and DPPH scavenging activities of G. mediosinense. Gallic Acid 22-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 31679283-12 2019 This study shows that gallic acid, a well-recognized phenolic acid, is responsible for the AChE-inhibitory and DPPH scavenging activities of G. mediosinense. phenolic acid 53-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 30380560-7 2019 The acetylcholinesterase inhibitor, neostigmine (NEO; 0.5 mumol/L), also decreased transmitter exocytosis. Neostigmine 49-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 30577562-1 2018 It has been reported that donepezil and rivastigmine, the acetylcholinesterase (AchE) inhibitors commonly used in the treatment of Alzheimer"s disease (AD), do not only inhibit AChE but also have antioxidant properties. Donepezil 26-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 31227679-4 2019 OBJECTIVE: In this study, AChE activity was assessed in occupational exposure to chromium (VI) and co-exposure to nickel (II) and chromium (VI). Chromium 81-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 31227679-4 2019 OBJECTIVE: In this study, AChE activity was assessed in occupational exposure to chromium (VI) and co-exposure to nickel (II) and chromium (VI). Nickel 114-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 31227679-4 2019 OBJECTIVE: In this study, AChE activity was assessed in occupational exposure to chromium (VI) and co-exposure to nickel (II) and chromium (VI). Chromium 130-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 31227679-10 2019 Subjects with chromium (VI) exposure contained significantly higher inhibition of AChE activity (p < 0.001) than workers with co-exposure to nickel (II) and chromium (VI). Chromium 14-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 30577562-1 2018 It has been reported that donepezil and rivastigmine, the acetylcholinesterase (AchE) inhibitors commonly used in the treatment of Alzheimer"s disease (AD), do not only inhibit AChE but also have antioxidant properties. Donepezil 26-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 30577562-1 2018 It has been reported that donepezil and rivastigmine, the acetylcholinesterase (AchE) inhibitors commonly used in the treatment of Alzheimer"s disease (AD), do not only inhibit AChE but also have antioxidant properties. Donepezil 26-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-181 30577562-1 2018 It has been reported that donepezil and rivastigmine, the acetylcholinesterase (AchE) inhibitors commonly used in the treatment of Alzheimer"s disease (AD), do not only inhibit AChE but also have antioxidant properties. Rivastigmine 40-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 30577562-1 2018 It has been reported that donepezil and rivastigmine, the acetylcholinesterase (AchE) inhibitors commonly used in the treatment of Alzheimer"s disease (AD), do not only inhibit AChE but also have antioxidant properties. Rivastigmine 40-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 30577562-1 2018 It has been reported that donepezil and rivastigmine, the acetylcholinesterase (AchE) inhibitors commonly used in the treatment of Alzheimer"s disease (AD), do not only inhibit AChE but also have antioxidant properties. Rivastigmine 40-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-181 30577562-8 2018 These observations suggest that the fluoride-induced oxidative stress may suppress the antioxidant action of AChE inhibitors. Fluorides 36-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 30427781-13 2018 There were significant relationships between AChE activity with P and PTH. Phosphorus 64-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 30567381-2 2018 Although moderate inhibitory effect was observed for the chalcones against AChE, derivatives 2h, 2j and 2n exhibited significant inhibitory effect against BChE and BACE-1. Chalcones 57-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 30567381-3 2018 The 2-aryl-7-fluoro-8-iodoflavonols 3b and 3c, on the other hand, exhibited increased activity and selectivity against AChE and reduced effect on BACE-1. 2-aryl-7-fluoro-8-iodoflavonols 4-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 30567381-4 2018 The flavonols 3h, 3i, 3k, 3l and 3p exhibited moderate inhibitory effect against AChE, but significant inhibition against BChE. Flavonols 4-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 30567381-7 2018 Similarly docking studies predicted interaction of the most active compounds with both CAS and PAS of either AChE or BChE with mixed type of enzyme inhibition confirmed by kinetic studies. Calcium 87-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 30567381-7 2018 Similarly docking studies predicted interaction of the most active compounds with both CAS and PAS of either AChE or BChE with mixed type of enzyme inhibition confirmed by kinetic studies. Protactinium 95-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 30218924-5 2018 The PtPd@NCS nanocomposites were used as an electrode material to prepare acetylcholinesterase (AChE) biosensors for detecting organophosphate pesticides. Organophosphates 127-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 30362667-1 2018 The current standard therapy to counteract organophosphate intoxication is not effective in equal measure against all types of organophosphorus compounds (OPCs), as the outcome of oxime-induced reactivation of inactivated acetylcholinesterase (AChE) strongly depends on the particular OPC. Oximes 180-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 222-242 30362667-1 2018 The current standard therapy to counteract organophosphate intoxication is not effective in equal measure against all types of organophosphorus compounds (OPCs), as the outcome of oxime-induced reactivation of inactivated acetylcholinesterase (AChE) strongly depends on the particular OPC. Oximes 180-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 244-248 30462502-0 2018 Structural Insights of Stereospecific Inhibition of Human Acetylcholinesterase by VX and Subsequent Reactivation by HI-6. asoxime chloride 116-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 30462502-1 2018 Over 50 years ago, the toxicity of irreversible organophosphate inhibitors targeting human acetylcholinesterase (hAChE) was observed to be stereospecific. Organophosphates 48-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 30462502-1 2018 Over 50 years ago, the toxicity of irreversible organophosphate inhibitors targeting human acetylcholinesterase (hAChE) was observed to be stereospecific. Organophosphates 48-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-118 30462502-4 2018 Beyond identifying hAChE structural features that lend themselves to stereospecific inhibition, structures of the reactivator HI-6 bound to hAChE inhibited by VX enantiomers of varying toxicity, or in its uninhibited state, were obtained. asoxime chloride 126-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-145 30218924-5 2018 The PtPd@NCS nanocomposites were used as an electrode material to prepare acetylcholinesterase (AChE) biosensors for detecting organophosphate pesticides. Organophosphates 127-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 30218924-8 2018 The AChE biosensor was also applied in real samples for detecting organophosphate pesticides and exhibited acceptable recovery. Organophosphates 66-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 30312685-0 2018 Interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators: Analysis of reactivation and inhibition kinetics in vitro. Oximes 123-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 30312685-1 2018 Poisoning by organophosphorus compounds (OP) is characterized by inhibition of the key enzyme acetylcholinesterase (AChE) and potentially fatal outcomes in humans. Organophosphorus Compounds 13-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 30312685-1 2018 Poisoning by organophosphorus compounds (OP) is characterized by inhibition of the key enzyme acetylcholinesterase (AChE) and potentially fatal outcomes in humans. Organophosphorus Compounds 13-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 30312685-2 2018 Insufficient efficacy of the standard therapy with atropine and AChE reactivators (oximes) against certain OP initiated synthesis of novel non-oxime reactivators basing on the common structure 4-amino-2-((diethylamino)methyl)phenol (ADOC). Oximes 83-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 30312685-2 2018 Insufficient efficacy of the standard therapy with atropine and AChE reactivators (oximes) against certain OP initiated synthesis of novel non-oxime reactivators basing on the common structure 4-amino-2-((diethylamino)methyl)phenol (ADOC). Oximes 83-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 30312685-3 2018 Recently, we reported of a pyrrolidine-bearing ADOC analogue (3 l) with a remarkable ability to reactivate OP-inhibited AChE. pyrrolidine 27-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 30312685-4 2018 This in vitro study was undertaken to determine reactivity, affinity and overall reactivation constants of 3 l, the reference compound ADOC and two structural analogues with human AChE inhibited by paraoxon, sarin, cyclosarin and VX. Paraoxon 198-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 30312685-4 2018 This in vitro study was undertaken to determine reactivity, affinity and overall reactivation constants of 3 l, the reference compound ADOC and two structural analogues with human AChE inhibited by paraoxon, sarin, cyclosarin and VX. cyclohexyl methylphosphonofluoridate 215-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 30267791-0 2018 MIA-QSAR based model for bioactivity prediction of flavonoid derivatives as acetylcholinesterase inhibitors. Flavonoids 51-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 30312685-8 2018 A combination of 3 l and the bispyridinium oxime HI-6 was tested to reactivate OP-inhibited AChE: The superior reactivator of the respective OP-AChE combination dominated the reactivation process and a synergistic effect could not be observed. bispyridinium oxime 29-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 30267791-3 2018 This study focuses on constructing an efficient QSAR model using a dataset of 52 flavonoid derivatives (substituted with amino-alkyl, alkoxy, alkyl-amines, and piperidine groups) as active compounds against acetylcholinesterase inhibitors (AChE). Flavonoids 81-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-238 30312685-8 2018 A combination of 3 l and the bispyridinium oxime HI-6 was tested to reactivate OP-inhibited AChE: The superior reactivator of the respective OP-AChE combination dominated the reactivation process and a synergistic effect could not be observed. asoxime chloride 49-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 30267791-3 2018 This study focuses on constructing an efficient QSAR model using a dataset of 52 flavonoid derivatives (substituted with amino-alkyl, alkoxy, alkyl-amines, and piperidine groups) as active compounds against acetylcholinesterase inhibitors (AChE). Flavonoids 81-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 240-244 30383374-0 2018 Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents. pyridinium oximes 0-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 30267791-3 2018 This study focuses on constructing an efficient QSAR model using a dataset of 52 flavonoid derivatives (substituted with amino-alkyl, alkoxy, alkyl-amines, and piperidine groups) as active compounds against acetylcholinesterase inhibitors (AChE). amino 121-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-238 30267791-3 2018 This study focuses on constructing an efficient QSAR model using a dataset of 52 flavonoid derivatives (substituted with amino-alkyl, alkoxy, alkyl-amines, and piperidine groups) as active compounds against acetylcholinesterase inhibitors (AChE). alkoxyl radical 134-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-238 30267791-3 2018 This study focuses on constructing an efficient QSAR model using a dataset of 52 flavonoid derivatives (substituted with amino-alkyl, alkoxy, alkyl-amines, and piperidine groups) as active compounds against acetylcholinesterase inhibitors (AChE). alkyl-amines 142-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-238 30267791-3 2018 This study focuses on constructing an efficient QSAR model using a dataset of 52 flavonoid derivatives (substituted with amino-alkyl, alkoxy, alkyl-amines, and piperidine groups) as active compounds against acetylcholinesterase inhibitors (AChE). piperidine 160-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-238 30383374-0 2018 Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents. Chlorine 40-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 30383374-5 2018 Its overall reactivation of sarin-, VX-, and cyclosarin-inhibited AChE was, respectively, 3-, 7-, and 8-fold higher than by K027. cyclohexyl methylphosphonofluoridate 45-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 30558201-4 2018 The AChE/MHCS/GCE electrochemical sensor response exhibited two good linear ranges at the incubation time of 10 min at the Malathion concentration ranges of 0.01 to 100 ppb and 100 to 600 ppb, with a detection limit of 0.0148 ppb (S/N = 3). Malathion 123-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 30558201-5 2018 The AChE/Fe3O4@MHCS/GCE electrochemical sensor that was operated with an incubation time of 12 min at the malathion concentration ranges between 0.01-50 ppb and 50-600 ppb had a detection limit of 0.0182 ppb (S/N = 3). Malathion 106-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 30558201-0 2018 Acetylcholinesterase Biosensor Based On Mesoporous Hollow Carbon Spheres/Core-Shell Magnetic Nanoparticles-Modified Electrode for the Detection of Organophosphorus Pesticides. Carbon 58-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 30558201-6 2018 Moreover, the AChE/MHCS/GCE and AChE/Fe3O4@MHCS/GCE biosensors were effective for the detection of real samples, and were demonstrated to be suitable for the field-testing of organophosphorus pesticide (OP) residues. organophosphorus 175-191 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 30558201-0 2018 Acetylcholinesterase Biosensor Based On Mesoporous Hollow Carbon Spheres/Core-Shell Magnetic Nanoparticles-Modified Electrode for the Detection of Organophosphorus Pesticides. organophosphorus 147-163 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 30544832-2 2018 All the compounds were found to be potent inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), two enzymes responsible for the hydrolysis of the neurotransmitter acetylcholine in Alzheimer"s disease patient brains. Acetylcholine 61-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 30563111-2 2018 Cholinesterases, acetylcholinesterase, and butyrylcholinesterase, are reported to be involved in detoxification processes owing to their capability of scavenging organophosphates and carbamates. Organophosphates 162-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 30515636-3 2018 Coumarin based conjugates have been described as potential AChE, BuChE, MAO and beta-amyloid inhibitors. coumarin 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 30563111-2 2018 Cholinesterases, acetylcholinesterase, and butyrylcholinesterase, are reported to be involved in detoxification processes owing to their capability of scavenging organophosphates and carbamates. Carbamates 183-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 30265992-0 2018 Design, synthesis and evaluation of new classes of nonquaternary reactivators for acetylcholinesterase inhibited by organophosphates. Organophosphates 116-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 30518102-9 2018 The best sensitivities for DMMP and DIMP obtained by using a PEI-AchE coated sensor are 65 kHz and 200 kHz, respectively, whereas the best sensitivity when using multilayered interfaces is 30 kHz and 10 KHz for DIMP and DMMP, respectively. dimethyl methylphosphonate 27-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 30121001-2 2018 The 2-amino-4H-pyran bearing nitro groups on both the aryl rings showed the highest activity, with an IC50 of 1.98 +- 0.09 microM against acetylcholinesterase (AChE) and 10.62 +- 0.21 microM against butyrylcholinesterase (BChE), the inhibition mechanisms on AChE and BChE receptors were revealed by means of molecular docking simulations. 2-amino-4h-pyran 4-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 30121001-2 2018 The 2-amino-4H-pyran bearing nitro groups on both the aryl rings showed the highest activity, with an IC50 of 1.98 +- 0.09 microM against acetylcholinesterase (AChE) and 10.62 +- 0.21 microM against butyrylcholinesterase (BChE), the inhibition mechanisms on AChE and BChE receptors were revealed by means of molecular docking simulations. 2-amino-4h-pyran 4-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 30121001-2 2018 The 2-amino-4H-pyran bearing nitro groups on both the aryl rings showed the highest activity, with an IC50 of 1.98 +- 0.09 microM against acetylcholinesterase (AChE) and 10.62 +- 0.21 microM against butyrylcholinesterase (BChE), the inhibition mechanisms on AChE and BChE receptors were revealed by means of molecular docking simulations. 2-amino-4h-pyran 4-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 258-262 30121001-2 2018 The 2-amino-4H-pyran bearing nitro groups on both the aryl rings showed the highest activity, with an IC50 of 1.98 +- 0.09 microM against acetylcholinesterase (AChE) and 10.62 +- 0.21 microM against butyrylcholinesterase (BChE), the inhibition mechanisms on AChE and BChE receptors were revealed by means of molecular docking simulations. nitro 29-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 30121001-2 2018 The 2-amino-4H-pyran bearing nitro groups on both the aryl rings showed the highest activity, with an IC50 of 1.98 +- 0.09 microM against acetylcholinesterase (AChE) and 10.62 +- 0.21 microM against butyrylcholinesterase (BChE), the inhibition mechanisms on AChE and BChE receptors were revealed by means of molecular docking simulations. nitro 29-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 30121001-2 2018 The 2-amino-4H-pyran bearing nitro groups on both the aryl rings showed the highest activity, with an IC50 of 1.98 +- 0.09 microM against acetylcholinesterase (AChE) and 10.62 +- 0.21 microM against butyrylcholinesterase (BChE), the inhibition mechanisms on AChE and BChE receptors were revealed by means of molecular docking simulations. nitro 29-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 258-262 30343499-0 2018 Thiazole-substituted benzoylpiperazine derivatives as acetylcholinesterase inhibitors. Thiazoles 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 30343499-0 2018 Thiazole-substituted benzoylpiperazine derivatives as acetylcholinesterase inhibitors. 1-Benzoylpiperazine 21-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 30343499-1 2018 Hit, Lead & Candidate Discovery After acetylcholine is released into the synaptic cleft, it is reabsorbed or deactivated by acetylcholinesterase (AChE). Adenosine Monophosphate 11-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 30343499-1 2018 Hit, Lead & Candidate Discovery After acetylcholine is released into the synaptic cleft, it is reabsorbed or deactivated by acetylcholinesterase (AChE). Adenosine Monophosphate 11-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 30343499-1 2018 Hit, Lead & Candidate Discovery After acetylcholine is released into the synaptic cleft, it is reabsorbed or deactivated by acetylcholinesterase (AChE). Acetylcholine 42-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 30343499-1 2018 Hit, Lead & Candidate Discovery After acetylcholine is released into the synaptic cleft, it is reabsorbed or deactivated by acetylcholinesterase (AChE). Acetylcholine 42-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 30343499-3 2018 Drugs, such as tacrine, rivastigmine, donepezil, and galantamine are known as acetylcholinesterase inhibitors. Tacrine 15-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 30343499-3 2018 Drugs, such as tacrine, rivastigmine, donepezil, and galantamine are known as acetylcholinesterase inhibitors. Rivastigmine 24-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 30343499-3 2018 Drugs, such as tacrine, rivastigmine, donepezil, and galantamine are known as acetylcholinesterase inhibitors. Donepezil 38-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 30343499-3 2018 Drugs, such as tacrine, rivastigmine, donepezil, and galantamine are known as acetylcholinesterase inhibitors. Galantamine 53-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 30343499-7 2018 In this study, 66 original piperazinyl thiazole derivatives were synthesized by the reaction of piperazine N"-benzoyl thioamides and bromoacetophenones to inhibit AChE. piperazinyl thiazole 27-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 30343499-7 2018 In this study, 66 original piperazinyl thiazole derivatives were synthesized by the reaction of piperazine N"-benzoyl thioamides and bromoacetophenones to inhibit AChE. piperazine n"-benzoyl thioamides 96-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 30343499-7 2018 In this study, 66 original piperazinyl thiazole derivatives were synthesized by the reaction of piperazine N"-benzoyl thioamides and bromoacetophenones to inhibit AChE. phenacyl bromide 133-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 29447012-0 2018 Structure-activity relationship investigation of tertiary amine derivatives of cinnamic acid as acetylcholinesterase and butyrylcholinesterase inhibitors: compared with that of phenylpropionic acid, sorbic acid and hexanoic acid. tertiary amine 49-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 29447012-0 2018 Structure-activity relationship investigation of tertiary amine derivatives of cinnamic acid as acetylcholinesterase and butyrylcholinesterase inhibitors: compared with that of phenylpropionic acid, sorbic acid and hexanoic acid. cinnamic 79-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 29447012-1 2018 In the present investigation, 48 new tertiary amine derivatives of cinnamic acid, phenylpropionic acid, sorbic acid and hexanoic acid (4d-6g, 10d-12g, 16d-18g and 22d-24g) were designed, synthesized and evaluated for the effect on AChE and BChE in vitro. tertiary amine 37-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 231-235 29447012-4 2018 Unsaturated bond and benzene ring in cinnamic acid scaffold seems important for the inhibitory activity against AChE. Benzene 21-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 29447012-4 2018 Unsaturated bond and benzene ring in cinnamic acid scaffold seems important for the inhibitory activity against AChE. cinnamic acid 37-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 29651876-1 2018 The inhibition of the enzyme acetylcholinesterase (AChE) increases the levels of the neurotransmitter acetylcholine and symptomatically improves the affected cognitive function. Acetylcholine 29-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 30284486-1 2018 Based on the structural analysis of tricyclic scaffolds as butyrylcholinesterase (BuChE) inhibitors, a series of pyrazolo[1,5-c][1,3]benzoxazin-5(5H)-one derivatives were designed, synthesized and evaluated for their acetylcholinesterase (AChE) and BuChE inhibitory activity. pyrazolo(1,5-c)(1,3)benzoxazin-5(5H)-one 113-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 217-237 30284486-1 2018 Based on the structural analysis of tricyclic scaffolds as butyrylcholinesterase (BuChE) inhibitors, a series of pyrazolo[1,5-c][1,3]benzoxazin-5(5H)-one derivatives were designed, synthesized and evaluated for their acetylcholinesterase (AChE) and BuChE inhibitory activity. pyrazolo(1,5-c)(1,3)benzoxazin-5(5H)-one 113-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 239-243 30105650-11 2018 Further, NaHS administration normalized nuclear factor erythroid 2-related factor 2 expression and acetylcholinesterase (AChE) activity in the brain of Hcy-treated animals. sodium bisulfide 9-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 30232815-7 2018 For the second system, a solution of acetylcholinesterase (AChE) (0.08 U/mL) in PBS was added to the nylon thread, and increasing concentrations of acetylthiocholine (ATC) (0-9.84 mg/mL) was added and measured by CV. Lead 80-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 30232815-7 2018 For the second system, a solution of acetylcholinesterase (AChE) (0.08 U/mL) in PBS was added to the nylon thread, and increasing concentrations of acetylthiocholine (ATC) (0-9.84 mg/mL) was added and measured by CV. Lead 80-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 30232815-8 2018 The current output from the oxidation of thiocholine (produced by AChE reacting with ATC) was proportional to the concentrations of ATC added to the thread. Thiocholine 41-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 30280314-6 2018 In both approaches, mixtures of diluted human whole blood with and without VX were mixed with a non-endogenous AChE specific substrate, 1,1-dimethyl-4-acetylthiomethylpiperidinium (MATP+). 1,1-dimethyl-4-acetylthiomethylpiperidinium 136-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 30291660-2 2018 These novel N-substituted tetrahydropyrimidines based on phenylthiourea showed good inhibitory action against acetylcholinesterase (AChE), alpha-glycosidase, and human carbonic anhydrase (hCA) isoforms I and II. n-substituted tetrahydropyrimidines 12-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 30291660-2 2018 These novel N-substituted tetrahydropyrimidines based on phenylthiourea showed good inhibitory action against acetylcholinesterase (AChE), alpha-glycosidase, and human carbonic anhydrase (hCA) isoforms I and II. n-substituted tetrahydropyrimidines 12-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 30291660-2 2018 These novel N-substituted tetrahydropyrimidines based on phenylthiourea showed good inhibitory action against acetylcholinesterase (AChE), alpha-glycosidase, and human carbonic anhydrase (hCA) isoforms I and II. Phenylthiourea 57-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 30291660-2 2018 These novel N-substituted tetrahydropyrimidines based on phenylthiourea showed good inhibitory action against acetylcholinesterase (AChE), alpha-glycosidase, and human carbonic anhydrase (hCA) isoforms I and II. Phenylthiourea 57-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 30384187-1 2018 Affinity chromatography on procainamide-Sepharose has been an important step in the purification of butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) since its introduction in 1978. Procainamide 27-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 30384187-1 2018 Affinity chromatography on procainamide-Sepharose has been an important step in the purification of butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) since its introduction in 1978. Procainamide 27-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 30384187-1 2018 Affinity chromatography on procainamide-Sepharose has been an important step in the purification of butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) since its introduction in 1978. Sepharose 40-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 30384187-1 2018 Affinity chromatography on procainamide-Sepharose has been an important step in the purification of butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) since its introduction in 1978. Sepharose 40-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 30384187-9 2018 Procainamide-Sepharose will continue to be useful for purification of AChE. Procainamide 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 30384187-9 2018 Procainamide-Sepharose will continue to be useful for purification of AChE. Sepharose 13-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 29166796-0 2018 Structure-activity relationship investigation of benzamide and picolinamide derivatives containing dimethylamine side chain as acetylcholinesterase inhibitors. benzamide 49-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 29166796-0 2018 Structure-activity relationship investigation of benzamide and picolinamide derivatives containing dimethylamine side chain as acetylcholinesterase inhibitors. picolinamide 63-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 29166796-0 2018 Structure-activity relationship investigation of benzamide and picolinamide derivatives containing dimethylamine side chain as acetylcholinesterase inhibitors. dimethylamine 99-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 29166796-2 2018 Structure-activity relationship investigation revealed that the substituted position of dimethylamine side chain markedly influenced the inhibitory activity and selectivity against AChE and BChE. dimethylamine 88-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 29873262-2 2018 Acetylcholinesterase (AChE), which is most widely known for the hydrolysis of the neurotransmitter acetylcholine, has a peripheral allosteric subsite responsible for amyloidosis in Alzheimer"s disease through interaction with amyloid beta-peptide. Acetylcholine 99-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 29873262-2 2018 Acetylcholinesterase (AChE), which is most widely known for the hydrolysis of the neurotransmitter acetylcholine, has a peripheral allosteric subsite responsible for amyloidosis in Alzheimer"s disease through interaction with amyloid beta-peptide. Acetylcholine 99-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 30643787-4 2018 Galantamine is an acetylcholinesterase inhibitor that is also a positive allosteric modulator at the alpha4beta2 and alpha7nACh receptors. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 30265992-2 2018 It was found that substituted salicylaldehydes conjugated to aminobenzamide through piperidine would produce efficient reactivators for sarin, VX and tabun inhibited hAChE, such as L6M1R3, L6M1R5 to L6M1R7, L4M1R3 and L4M1R5 to L4M1R7. salicylaldehyde 30-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-171 30265992-2 2018 It was found that substituted salicylaldehydes conjugated to aminobenzamide through piperidine would produce efficient reactivators for sarin, VX and tabun inhibited hAChE, such as L6M1R3, L6M1R5 to L6M1R7, L4M1R3 and L4M1R5 to L4M1R7. anthranilamide 61-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-171 30265992-2 2018 It was found that substituted salicylaldehydes conjugated to aminobenzamide through piperidine would produce efficient reactivators for sarin, VX and tabun inhibited hAChE, such as L6M1R3, L6M1R5 to L6M1R7, L4M1R3 and L4M1R5 to L4M1R7. piperidine 84-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-171 30265992-3 2018 The in vitro reactivation experiment for pesticides inhibited hAChE of these new synthesized oximes were conducted for the first time. Oximes 93-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-67 30265992-5 2018 It was found that introduction of peripheral site ligands could increase oximes" binding affinity for inhibited hAChE in most cases, which resulted in greater reactivation ability. Oximes 73-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-117 30470757-4 2018 The synthetic utility of this method is demonstrated by late-stage difluoroalkylation of donepezil, a well-known acetylcholinesterase inhibitor used to treat the Alzheimer"s disease. Donepezil 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-133 30015476-3 2018 We identified an octapeptide, which interacts with the catalytic anionic site (CAS) of AChE enzyme and inhibits its activity. octapeptide 17-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 30088833-0 2018 Effects of aryl methanesulfonate derivatives on acetylcholinesterase and butyrylcholinesterase. aryl methanesulfonate 11-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 30105650-11 2018 Further, NaHS administration normalized nuclear factor erythroid 2-related factor 2 expression and acetylcholinesterase (AChE) activity in the brain of Hcy-treated animals. sodium bisulfide 9-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 30105650-11 2018 Further, NaHS administration normalized nuclear factor erythroid 2-related factor 2 expression and acetylcholinesterase (AChE) activity in the brain of Hcy-treated animals. Homocysteine 152-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 30105650-11 2018 Further, NaHS administration normalized nuclear factor erythroid 2-related factor 2 expression and acetylcholinesterase (AChE) activity in the brain of Hcy-treated animals. Homocysteine 152-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 30105650-13 2018 The results clearly demonstrate that NaHS treatment significantly ameliorates Hcy-induced cognitive impairment by attenuating oxidative stress, improving antioxidant status, and modulating AChE activity thereby suggesting potential of H2S as a therapeutic molecule. sodium bisulfide 37-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-193 30105650-13 2018 The results clearly demonstrate that NaHS treatment significantly ameliorates Hcy-induced cognitive impairment by attenuating oxidative stress, improving antioxidant status, and modulating AChE activity thereby suggesting potential of H2S as a therapeutic molecule. Homocysteine 78-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-193 30290248-0 2018 Zebrafish bio-assay guided isolation of human acetylcholinesterase inhibitory trans-tephrostachin from Tephrosia purpurea (L.) Pers. trans-Tephrostachin 78-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 30290248-3 2018 However, the inhibition constant (Ki) was found to be 36.0 +- 0.4 muM with IC50 value of 20.0 +- 1.0 muM, whereas donepezil showed 3.2 +- 0.3 muM with the IC50 value of 0.12 +- 0.04 muM for human acetylcholinesterase. Donepezil 114-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 196-216 32254700-3 2018 Initially, the enzyme acetylcholinesterase (AChE) immobilized on the CdS/PEDOT photoanode could hydrolyze acetylthiocholine iodide (ATCh) into thiocholine as the electron donor to enhance the charge separation efficiency; thus, PEFC produced relatively high open circuit voltage (EOCV) upon illumination. pedot photoanode 73-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 32254700-3 2018 Initially, the enzyme acetylcholinesterase (AChE) immobilized on the CdS/PEDOT photoanode could hydrolyze acetylthiocholine iodide (ATCh) into thiocholine as the electron donor to enhance the charge separation efficiency; thus, PEFC produced relatively high open circuit voltage (EOCV) upon illumination. acetylthiocholine iodide 106-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 32254700-3 2018 Initially, the enzyme acetylcholinesterase (AChE) immobilized on the CdS/PEDOT photoanode could hydrolyze acetylthiocholine iodide (ATCh) into thiocholine as the electron donor to enhance the charge separation efficiency; thus, PEFC produced relatively high open circuit voltage (EOCV) upon illumination. acetylthiocholine iodide 132-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 32254700-3 2018 Initially, the enzyme acetylcholinesterase (AChE) immobilized on the CdS/PEDOT photoanode could hydrolyze acetylthiocholine iodide (ATCh) into thiocholine as the electron donor to enhance the charge separation efficiency; thus, PEFC produced relatively high open circuit voltage (EOCV) upon illumination. Thiocholine 112-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 32254700-3 2018 Initially, the enzyme acetylcholinesterase (AChE) immobilized on the CdS/PEDOT photoanode could hydrolyze acetylthiocholine iodide (ATCh) into thiocholine as the electron donor to enhance the charge separation efficiency; thus, PEFC produced relatively high open circuit voltage (EOCV) upon illumination. pefc 228-232 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 30424582-0 2018 Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon. Oximes 53-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 30424582-0 2018 Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon. Paraoxon 124-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 30307023-2 2018 However, very few works have ever found that the signal loss of thiocholine (TCh) during electrochemical processing is a key factor leading to the low sensitivity of acetylcholinesterase (AChE)-based OP electrochemical sensing platforms. Thiocholine 64-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-186 30307023-2 2018 However, very few works have ever found that the signal loss of thiocholine (TCh) during electrochemical processing is a key factor leading to the low sensitivity of acetylcholinesterase (AChE)-based OP electrochemical sensing platforms. Thiocholine 64-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-192 30307023-2 2018 However, very few works have ever found that the signal loss of thiocholine (TCh) during electrochemical processing is a key factor leading to the low sensitivity of acetylcholinesterase (AChE)-based OP electrochemical sensing platforms. Thiocholine 77-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-186 30307023-2 2018 However, very few works have ever found that the signal loss of thiocholine (TCh) during electrochemical processing is a key factor leading to the low sensitivity of acetylcholinesterase (AChE)-based OP electrochemical sensing platforms. Thiocholine 77-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-192 30307023-4 2018 For the first time, Michael addition is introduced into an AChE-based OP electrochemical sensing platform to enrich the electrochemical intermediate TCh. Thiocholine 149-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 30172744-0 2018 Acetylcholinesterase biosensor based on functionalized surface of carbon nanotubes for monocrotophos detection. Carbon 66-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 30172744-3 2018 In this study, multi-walled carbon nanotubes (MWCNTs) were selected as acetylcholinesterase (AChE) carrier and their surface was modified by introducing different functional groups (-SH, -NH2, -Cl, -OH), hydrophobic alkyl groups (-CH3, -(CH2)2CH3, -(CH2)7CH3, -(CH2)15CH3) and ionic liquids (-IL1, -IL2). Carbon 28-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 30172744-3 2018 In this study, multi-walled carbon nanotubes (MWCNTs) were selected as acetylcholinesterase (AChE) carrier and their surface was modified by introducing different functional groups (-SH, -NH2, -Cl, -OH), hydrophobic alkyl groups (-CH3, -(CH2)2CH3, -(CH2)7CH3, -(CH2)15CH3) and ionic liquids (-IL1, -IL2). Carbon 28-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 30255953-3 2018 Also, in the other section of this study, novel sulfamate derivatives of menthol were tested against some metabolic enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and carbonic anhydrase I and II enzymes (hCAs I and II). Menthol 73-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 30255953-3 2018 Also, in the other section of this study, novel sulfamate derivatives of menthol were tested against some metabolic enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and carbonic anhydrase I and II enzymes (hCAs I and II). Menthol 73-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-160 30201403-0 2018 1-Naphthyl acetate: A chromogenic substrate for the detection of erythrocyte acetylcholinesterase activity. alpha-naphthyl acetate 0-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 30201403-2 2018 Acetylthiocholine (ATCh) is the most popular substrate for the detection of AChE activity. Acetylthiocholine 0-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 30201403-2 2018 Acetylthiocholine (ATCh) is the most popular substrate for the detection of AChE activity. Acetylthiocholine 19-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 30201403-6 2018 The alternative substrates for AChE were screened in terms of high Goldscore and favorable TIE in comparison to acetylcholine (ACh)-AChE complex and other relevant esterases. Acetylcholine 112-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 30201403-6 2018 The alternative substrates for AChE were screened in terms of high Goldscore and favorable TIE in comparison to acetylcholine (ACh)-AChE complex and other relevant esterases. Acetylcholine 112-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 30201403-7 2018 Among the screened substrates, 1-Naphthyl acetate (1-NA) exhibited the most favorable interaction with AChE in terms of highest TIE and corresponding high Goldscore. alpha-naphthyl acetate 31-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 30201403-7 2018 Among the screened substrates, 1-Naphthyl acetate (1-NA) exhibited the most favorable interaction with AChE in terms of highest TIE and corresponding high Goldscore. 1-na 51-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 30201403-10 2018 We observed 1-NA to be a better alternative substrate for AChE than ATCh in terms of lower Km value. 1-na 12-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 30201403-12 2018 Therefore, we propose that 1-NA can be an attractive chromogenic substrate for the measurement of AChE activity, and it possess the potential to detect organophosphorus pesticide (OP) poisoning. 1-na 27-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 30048725-3 2018 Forsythiaside and rutin both can bind to AChE to form forsythiaside-AChE and rutin-AChE complex, and thus quench the intrinsic fluorescence of AChE. forsythiaside 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 30048725-3 2018 Forsythiaside and rutin both can bind to AChE to form forsythiaside-AChE and rutin-AChE complex, and thus quench the intrinsic fluorescence of AChE. forsythiaside 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 30048725-3 2018 Forsythiaside and rutin both can bind to AChE to form forsythiaside-AChE and rutin-AChE complex, and thus quench the intrinsic fluorescence of AChE. forsythiaside 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 30048725-3 2018 Forsythiaside and rutin both can bind to AChE to form forsythiaside-AChE and rutin-AChE complex, and thus quench the intrinsic fluorescence of AChE. Rutin 18-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 30048725-3 2018 Forsythiaside and rutin both can bind to AChE to form forsythiaside-AChE and rutin-AChE complex, and thus quench the intrinsic fluorescence of AChE. Rutin 18-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 30048725-3 2018 Forsythiaside and rutin both can bind to AChE to form forsythiaside-AChE and rutin-AChE complex, and thus quench the intrinsic fluorescence of AChE. Rutin 18-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 30048725-3 2018 Forsythiaside and rutin both can bind to AChE to form forsythiaside-AChE and rutin-AChE complex, and thus quench the intrinsic fluorescence of AChE. Rutin 18-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 30048725-3 2018 Forsythiaside and rutin both can bind to AChE to form forsythiaside-AChE and rutin-AChE complex, and thus quench the intrinsic fluorescence of AChE. forsythiaside 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 30048725-3 2018 Forsythiaside and rutin both can bind to AChE to form forsythiaside-AChE and rutin-AChE complex, and thus quench the intrinsic fluorescence of AChE. forsythiaside 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 30048725-3 2018 Forsythiaside and rutin both can bind to AChE to form forsythiaside-AChE and rutin-AChE complex, and thus quench the intrinsic fluorescence of AChE. forsythiaside 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 30048725-3 2018 Forsythiaside and rutin both can bind to AChE to form forsythiaside-AChE and rutin-AChE complex, and thus quench the intrinsic fluorescence of AChE. forsythiaside 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 30048725-3 2018 Forsythiaside and rutin both can bind to AChE to form forsythiaside-AChE and rutin-AChE complex, and thus quench the intrinsic fluorescence of AChE. Rutin 77-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 30048725-5 2018 Forsythiaside and rutin show some properties in common, including the stoichiometric binding ratio of 1:1 with AChE and the full quenching of AChE fluorescence. forsythiaside 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 30048725-5 2018 Forsythiaside and rutin show some properties in common, including the stoichiometric binding ratio of 1:1 with AChE and the full quenching of AChE fluorescence. forsythiaside 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 30048725-5 2018 Forsythiaside and rutin show some properties in common, including the stoichiometric binding ratio of 1:1 with AChE and the full quenching of AChE fluorescence. Rutin 18-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 30048725-5 2018 Forsythiaside and rutin show some properties in common, including the stoichiometric binding ratio of 1:1 with AChE and the full quenching of AChE fluorescence. Rutin 18-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 30048725-6 2018 At the same time, the two compounds distinctly present some different characters, for example, the binding constant of rutin is less than that of forsythiaside, and the interaction force and the affinity between forsythiaside and AChE are much bigger than that of rutin. Rutin 119-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 230-234 30048725-7 2018 Spectroscopy data and docking analysis powerfully support the findings that forsythiaside inhibit AChE activity more strongly than rutin. forsythiaside 76-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 30255953-3 2018 Also, in the other section of this study, novel sulfamate derivatives of menthol were tested against some metabolic enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and carbonic anhydrase I and II enzymes (hCAs I and II). sulfamic acid 48-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 30255953-3 2018 Also, in the other section of this study, novel sulfamate derivatives of menthol were tested against some metabolic enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and carbonic anhydrase I and II enzymes (hCAs I and II). sulfamic acid 48-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-160 30220607-0 2018 Unexpected AChE inhibitory activity of (2E)alpha,beta-unsaturated fatty acids. (2e)alpha,beta-unsaturated fatty acids 39-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-15 30220607-3 2018 The results have shown trans 2-mono-unsaturated fatty acids are better inhibitors for AChE than their saturated analogs. 2-mono-unsaturated fatty acids 29-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 30340901-3 2018 Most of the d-xylose derivatives (6a-e) were selective for AChE and the compound 6e (IC50 = 2.2 nM for AChE and 4.93 nM for BuChE) was the most active compound for both enzymes. Xylose 12-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 30340901-3 2018 Most of the d-xylose derivatives (6a-e) were selective for AChE and the compound 6e (IC50 = 2.2 nM for AChE and 4.93 nM for BuChE) was the most active compound for both enzymes. Xylose 12-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 30340901-4 2018 The d-galactose derivative 8a was the most selective for AChE exhibiting an IC50 ratio of 7.6 for AChE over BuChE. Galactose 4-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 30340901-4 2018 The d-galactose derivative 8a was the most selective for AChE exhibiting an IC50 ratio of 7.6 for AChE over BuChE. Galactose 4-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 30048725-0 2018 Study of the interactions of forsythiaside and rutin with acetylcholinesterase (AChE). forsythiaside 29-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 30048725-0 2018 Study of the interactions of forsythiaside and rutin with acetylcholinesterase (AChE). forsythiaside 29-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 30048725-3 2018 Forsythiaside and rutin both can bind to AChE to form forsythiaside-AChE and rutin-AChE complex, and thus quench the intrinsic fluorescence of AChE. forsythiaside 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 30088833-6 2018 Aryl methanesulfonate derivatives were screened for their acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities. aryl methanesulfonate 0-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 30088833-6 2018 Aryl methanesulfonate derivatives were screened for their acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities. aryl methanesulfonate 0-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 30085899-2 2018 Acetylcholinesterase inhibitors (ChEi) may attenuate cognitive decline and mitigate BPSD. bpsd 84-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 29198175-0 2018 New semicarbazones as gorge-spanning ligands of acetylcholinesterase and potential new drugs against Alzheimer"s disease: Synthesis, molecular modeling, NMR, and biological evaluation. Semicarbazones 4-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 29934672-0 2018 Structure-activity relationship investigation of coumarin-chalcone hybrids with diverse side-chains as acetylcholinesterase and butyrylcholinesterase inhibitors. coumarin 49-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 29934672-0 2018 Structure-activity relationship investigation of coumarin-chalcone hybrids with diverse side-chains as acetylcholinesterase and butyrylcholinesterase inhibitors. Chalcone 58-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 29934672-3 2018 Here, we report the synthesis and testing of 36 new coumarin-chalcone hybrids (5d-7j, 9d-11f, 12k-13m) against AChE and BChE. coumarin 52-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 29934672-3 2018 Here, we report the synthesis and testing of 36 new coumarin-chalcone hybrids (5d-7j, 9d-11f, 12k-13m) against AChE and BChE. Chalcone 61-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 29934672-1 2018 Chalcones containing tertiary amine side-chains have potent activity as acetylcholinesterase (AChE) inhibitors. Chalcones 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 29934672-4 2018 The nature and position of the chalcone substituents had major effects on inhibitory activity as well as selectivity for AChE over BChE. Chalcone 31-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 29934672-1 2018 Chalcones containing tertiary amine side-chains have potent activity as acetylcholinesterase (AChE) inhibitors. Chalcones 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 29934672-5 2018 Compounds with para-substituted chalcone fragments in which the substituents were choline-like had potent activity against AChE and poor activity against BChE, while ortho-substituted analogs exhibited an opposite effect. Chalcone 32-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 29934672-1 2018 Chalcones containing tertiary amine side-chains have potent activity as acetylcholinesterase (AChE) inhibitors. Amines 30-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 29934672-5 2018 Compounds with para-substituted chalcone fragments in which the substituents were choline-like had potent activity against AChE and poor activity against BChE, while ortho-substituted analogs exhibited an opposite effect. Choline 82-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 29934672-9 2018 Overall, the results show that coumarin-chalcone hybrids with choline-like side-chains have promising activity and selectivity against AChE and be promising therapeutic leads for Alzheimer"s disease. coumarin 31-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 29934672-1 2018 Chalcones containing tertiary amine side-chains have potent activity as acetylcholinesterase (AChE) inhibitors. Amines 30-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 29934672-9 2018 Overall, the results show that coumarin-chalcone hybrids with choline-like side-chains have promising activity and selectivity against AChE and be promising therapeutic leads for Alzheimer"s disease. Chalcone 40-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 29934672-2 2018 However, the effects of the location of the tertiary amine groups as well as of other groups on AChE and butyrylcholinesterase (BChE) activity have not been reported. Amines 53-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 29934672-9 2018 Overall, the results show that coumarin-chalcone hybrids with choline-like side-chains have promising activity and selectivity against AChE and be promising therapeutic leads for Alzheimer"s disease. Choline 62-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 30311614-3 2018 Some compounds prepared showed AChE inhibitory potential in the low micromolar range similar to that obtained with donepezil, a commercially available cholinesterase inhibitor. Donepezil 115-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 30587482-4 2018 Excellent cholinesterase inhibitory potential was portrayed by 3-(n-heptylthio)-5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole; 6g against AChE (IC50; 38.35+-0.62muM) and BChE (IC50; 147.75+-0.67muM) enzymes. 3-(n-heptylthio)-5-(4-methoxyphenyl)-4-phenyl-4h-1,2,4-triazole 63-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 30405413-4 2018 However, several plant species producing diverse classes of alkaloids, coumarins, terpenes, and polyphenols have been assessed for their anti-AChE activity, becoming potential candidates for new anti-AD drugs. Alkaloids 60-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 30403599-1 2018 Acetylcholinesterase inhibitors, including Neostigmine, have been used to reverse neuromuscular blockage for many years. Neostigmine 43-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 30368973-0 2018 In vitro cytotoxic and in vivo antitumoral activities of some aminomethyl derivatives of 2,4-dihydro-3H-1,2,4-triazole-3-thiones-Evaluation of their acetylcholinesterase and carbonic anhydrase enzymes inhibition profiles. 2,4-dihydro-3h-1,2,4-triazole-3-thiones 89-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-169 30405413-4 2018 However, several plant species producing diverse classes of alkaloids, coumarins, terpenes, and polyphenols have been assessed for their anti-AChE activity, becoming potential candidates for new anti-AD drugs. Polyphenols 96-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 30402044-2 2018 Neostigmine suppressed (p < 0.05) LPS-stimulated synthesis of cytokines such as interleukin- (IL-) 1beta, IL-6, and tumor necrosis factor (TNF) alpha in the POA, and this effect was similar to that induced by the treatment with systemic AChE inhibitor-donepezil (2.5 mg/animal). Neostigmine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 240-244 30402044-2 2018 Neostigmine suppressed (p < 0.05) LPS-stimulated synthesis of cytokines such as interleukin- (IL-) 1beta, IL-6, and tumor necrosis factor (TNF) alpha in the POA, and this effect was similar to that induced by the treatment with systemic AChE inhibitor-donepezil (2.5 mg/animal). lps 37-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 240-244 30223122-2 2018 The compounds based on arylalkylaminoketone scaffold integrate the pharmacophoric elements of RRC-33, a S1R modulator developed by us, donepezil, a well-known AChE inhibitor, and curcumin, a natural antioxidant compound with neuroprotective properties. arylalkylaminoketone 23-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 29966870-0 2018 Design and synthesis of donepezil analogues as dual AChE and BACE-1 inhibitors. Donepezil 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 30192517-7 2018 It is also versatile for the detection of other organophosphate or carbamate pesticides, which have the inhibition ability toward AChE. Organophosphates 48-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 30192517-7 2018 It is also versatile for the detection of other organophosphate or carbamate pesticides, which have the inhibition ability toward AChE. Carbamates 67-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 30410615-0 2018 Synthesis of 3-aminocoumarin-N-benzylpyridinium conjugates with nanomolar inhibitory activity against acetylcholinesterase. 3-aminocoumarin-n-benzylpyridinium 13-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 30410615-1 2018 A series of 3-amino-6,7-dimethoxycoumarins conjugated with the N-benzylpyridinium moiety through an amide-bond linkage was synthesized and evaluated for their acetylcholinesterase inhibitory activity. 3-amino-6,7-dimethoxycoumarins 12-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 30410615-1 2018 A series of 3-amino-6,7-dimethoxycoumarins conjugated with the N-benzylpyridinium moiety through an amide-bond linkage was synthesized and evaluated for their acetylcholinesterase inhibitory activity. n-benzylpyridinium 63-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 30410615-1 2018 A series of 3-amino-6,7-dimethoxycoumarins conjugated with the N-benzylpyridinium moiety through an amide-bond linkage was synthesized and evaluated for their acetylcholinesterase inhibitory activity. Amides 100-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 30098983-1 2018 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 30098983-1 2018 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 30098983-1 2018 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Esters 15-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 30098983-1 2018 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Esters 15-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 30098983-1 2018 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates 37-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 30098983-1 2018 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates 37-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 30098983-1 2018 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Serine 147-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 30098983-1 2018 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Serine 147-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 30098983-1 2018 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates 215-224 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 30098983-1 2018 Carbamates are esters of substituted carbamic acids that react with acetylcholinesterase (AChE) by initially transferring the carbamoyl group to a serine residue in the enzyme active site accompanied by loss of the carbamate leaving group followed by hydrolysis of the carbamoyl enzyme. Carbamates 215-224 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 30098983-3 2018 Therefore, carbamates are effective AChE inhibitors that have been developed as insecticides and as therapeutic agents. Carbamates 11-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 30098983-7 2018 Furthermore, solvent deuterium oxide isotope effects for decarbamoylation decreased from 2.8 for N-monomethylcarbamoyl AChE to 1.1 for N,N-diethylcarbamoyl AChE, indicating a shift in the rate-limiting step from general acid-base catalysis to a likely conformational change in the distorted active site. Deuterium Oxide 21-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 30098983-7 2018 Furthermore, solvent deuterium oxide isotope effects for decarbamoylation decreased from 2.8 for N-monomethylcarbamoyl AChE to 1.1 for N,N-diethylcarbamoyl AChE, indicating a shift in the rate-limiting step from general acid-base catalysis to a likely conformational change in the distorted active site. Deuterium Oxide 21-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-160 29966870-3 2018 Profiling of donepezil, a potent acetylcholinesterase (hAChE) inhibitor, into BACE-1 inhibition was achieved through introduction of backbone amide linkers to the designed compounds which are capable of hydrogen-bonding with BACE-1 catalytic site. Amides 142-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-60 29966870-3 2018 Profiling of donepezil, a potent acetylcholinesterase (hAChE) inhibitor, into BACE-1 inhibition was achieved through introduction of backbone amide linkers to the designed compounds which are capable of hydrogen-bonding with BACE-1 catalytic site. Hydrogen 203-211 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-60 30159887-5 2018 Acetylcholinesterase inhibition results in the accumulation of excessive acetylcholine levels in synapses, leading to progression of toxic signs including hypersecretions, tremors, status epilepticus, respiratory distress, and death. Acetylcholine 73-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 30319199-0 2018 Whether Lack of Measurement of Erythrocyte Cholinesterase or Acetyl Cholinesterase Activity Providing us Misleading Information in Organophosphorus Exposure? organophosphorus 131-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-82 29019446-3 2018 In order to try to find out the reason for this, a computational study involving molecular docking, molecular dynamics, and binding energies calculations, was performed on the binding modes of HI-6 and HS-6 on human AChE (HssAChE) inhibited by those nerve agents. asoxime chloride 193-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 216-220 29019446-3 2018 In order to try to find out the reason for this, a computational study involving molecular docking, molecular dynamics, and binding energies calculations, was performed on the binding modes of HI-6 and HS-6 on human AChE (HssAChE) inhibited by those nerve agents. HS 6 202-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 216-220 30179754-0 2018 Establishment of a quantitative bioanalytical method for an acetylcholinesterase inhibitor Ethyl 3-(2-(4-fluorophenyl) amino)-4-phenylthiazol-5-yl)-3-oxopropanoate including its physicochemical characterization and in vitro metabolite profiling using Liquid Chromatography-Mass Spectrometry. ethyl 3-(2-(4-fluorophenyl) amino)-4-phenylthiazol-5-yl)-3-oxopropanoate 91-163 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 30179754-1 2018 Ethyl 3-(2-(4-fluorophenyl)amino)-4-phenylthiazo)-5-yl)-3-oxopropanoate is a novel molecule with potent acetylcholinesterase inhibition property. ethyl 3-(2-(4-fluorophenyl)amino)-4-phenylthiazo)-5-yl)-3-oxopropanoate 0-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 29804239-6 2018 Donepezil (DON), a centrally acting, reversible and non-competitive acetylcholinesterase (AChE) inhibitor, approved for use in Alzheimer"s disease (AD), may also attenuate EtOH-induced cognitive impairment. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 29804239-6 2018 Donepezil (DON), a centrally acting, reversible and non-competitive acetylcholinesterase (AChE) inhibitor, approved for use in Alzheimer"s disease (AD), may also attenuate EtOH-induced cognitive impairment. Donepezil 11-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 29804239-6 2018 Donepezil (DON), a centrally acting, reversible and non-competitive acetylcholinesterase (AChE) inhibitor, approved for use in Alzheimer"s disease (AD), may also attenuate EtOH-induced cognitive impairment. Ethanol 172-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 29804239-7 2018 Cognitive effects of DON might be due to an anti-apoptotic activity as some AChE inhibitors have been shown to have this property. Donepezil 21-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 28328690-7 2018 There is reasonable theoretical science to suggest pralidoxime in case of acetylcholinesterase inhibitor toxicity. pralidoxime 51-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 30524149-0 2018 Select beta- and gamma-branched 1-alkylpyrazol-4-yl methylcarbamates exhibit high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase. beta- and gamma-branched 1-alkylpyrazol-4-yl methylcarbamates 7-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 30524149-2 2018 With the goal of developing new species-selective and resistance-breaking acetylcholinesterase (AChE)-inhibiting mosquitocides, in this report we revisit the effects of carbamate substitution on aryl carbamates, and variation of the 1-alkyl group on pyrazol-4-yl methylcarbamates. Carbamates 169-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 30524149-2 2018 With the goal of developing new species-selective and resistance-breaking acetylcholinesterase (AChE)-inhibiting mosquitocides, in this report we revisit the effects of carbamate substitution on aryl carbamates, and variation of the 1-alkyl group on pyrazol-4-yl methylcarbamates. Carbamates 169-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 30524149-2 2018 With the goal of developing new species-selective and resistance-breaking acetylcholinesterase (AChE)-inhibiting mosquitocides, in this report we revisit the effects of carbamate substitution on aryl carbamates, and variation of the 1-alkyl group on pyrazol-4-yl methylcarbamates. pyrazol-4-yl methylcarbamates 250-279 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 30524149-6 2018 Molecular modeling studies suggest the lower species-selectivity of the aryl dimethylcarbamates can be attributed to a less flexible acyl pocket in AgAChE relative to hAChE. dimethylcarbamates 77-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-172 29096599-4 2018 Our findings points to two among the compounds studied: (E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hept-4-en-3-on and 1-(3,4-dihydroxy-5-methoxyphenyl)-7-(4-hydroxy-3- ethoxyphenyl) heptane-3,5-diyl diacetate, as promising new HssAChE inhibitors that could be as effective as DNP. (e)-1,7-bis(4-hydroxy-3-methoxyphenyl)hept-4-en-3-on 56-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 222-229 29096599-4 2018 Our findings points to two among the compounds studied: (E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hept-4-en-3-on and 1-(3,4-dihydroxy-5-methoxyphenyl)-7-(4-hydroxy-3- ethoxyphenyl) heptane-3,5-diyl diacetate, as promising new HssAChE inhibitors that could be as effective as DNP. 1-(3,4-dihydroxy-5-methoxyphenyl)-7-(4-hydroxy-3- ethoxyphenyl) heptane-3,5-diyl diacetate 113-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 222-229 30142564-3 2018 To increase the chemical diversity of cholinesterase inhibitors, a series of quinoline chalcones derivatives were tested against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) isoenzymes. quinoline chalcones 77-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-149 30080993-3 2018 It has been known that heroin hydrolysis to 6-MAM and morphine is accelerated by cholinesterases, including acetylcholinesterase (AChE) and/or butyrylcholinesterase (BChE). Heroin 23-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 30080993-3 2018 It has been known that heroin hydrolysis to 6-MAM and morphine is accelerated by cholinesterases, including acetylcholinesterase (AChE) and/or butyrylcholinesterase (BChE). Heroin 23-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 30080993-3 2018 It has been known that heroin hydrolysis to 6-MAM and morphine is accelerated by cholinesterases, including acetylcholinesterase (AChE) and/or butyrylcholinesterase (BChE). Morphine 54-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 30080993-3 2018 It has been known that heroin hydrolysis to 6-MAM and morphine is accelerated by cholinesterases, including acetylcholinesterase (AChE) and/or butyrylcholinesterase (BChE). Morphine 54-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 30080993-5 2018 Here we report the kinetic characterization of AChE, BChE, and a therapeutically promising cocaine hydrolase (CocH1) for heroin and 6-MAM hydrolyses under the same experimental conditions. Heroin 121-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 30080993-6 2018 It has been demonstrated that AChE and BChE have similar kcat values (2100 and 1840 min-1, respectively) against heroin, but with a large difference in KM (2170 and 120 muM, respectively). Heroin 113-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 30080993-7 2018 Both AChE and BChE can catalyze 6-MAM hydrolysis to morphine, with relatively lower catalytic efficiency compared to the heroin hydrolysis. Morphine 52-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 30080993-7 2018 Both AChE and BChE can catalyze 6-MAM hydrolysis to morphine, with relatively lower catalytic efficiency compared to the heroin hydrolysis. Heroin 121-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 30257474-0 2018 Molecular Modeling Studies on the Interactions of Aflatoxin B1 and Its Metabolites with Human Acetylcholinesterase. Aflatoxin B1 50-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 30257474-4 2018 It is believed that this could be related to the capacity of AFB1 and its metabolites in inhibiting the enzyme acetylcholinesterase (AChE). Aflatoxin B1 61-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 30257474-4 2018 It is believed that this could be related to the capacity of AFB1 and its metabolites in inhibiting the enzyme acetylcholinesterase (AChE). Aflatoxin B1 61-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 30257474-5 2018 In a previous work, we performed an inedited theoretical investigation on the binding modes of these molecules on the peripheral anionic site (PAS) of human AChE (HssAChE), revealing that the metabolites can also bind in the PAS in the same way as AFB1. Aminosalicylic Acid 143-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 30257474-5 2018 In a previous work, we performed an inedited theoretical investigation on the binding modes of these molecules on the peripheral anionic site (PAS) of human AChE (HssAChE), revealing that the metabolites can also bind in the PAS in the same way as AFB1. Aminosalicylic Acid 225-228 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 30257474-5 2018 In a previous work, we performed an inedited theoretical investigation on the binding modes of these molecules on the peripheral anionic site (PAS) of human AChE (HssAChE), revealing that the metabolites can also bind in the PAS in the same way as AFB1. Aflatoxin B1 248-252 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 30238673-8 2018 Moreover, our study reveals that BPA is an activator of AChE. bisphenol A 33-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 30017317-0 2018 Structure-based design, synthesis, and evaluation of structurally rigid donepezil analogues as dual AChE and BACE-1 inhibitors. Donepezil 72-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 30017317-3 2018 The hybrid compound 13 bearing 2-aminoquinoline scaffold exhibited potent AChE inhibition (IC50 value of 14.7 nM) and BACE-1 inhibition (IC50 value of 13.1 nM). 2-AMINOQUINOLINE 31-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 29966870-3 2018 Profiling of donepezil, a potent acetylcholinesterase (hAChE) inhibitor, into BACE-1 inhibition was achieved through introduction of backbone amide linkers to the designed compounds which are capable of hydrogen-bonding with BACE-1 catalytic site. Donepezil 13-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-60 30125110-2 2018 Quaternary oximes can regenerate AChE activity by displacing the phosphyl group of the nerve agent from the active site, but they are poorly distributed in the central nervous system. quaternary oximes 0-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 30125110-3 2018 A promising reactivator based on tetrahydroacridine linked to a nonquaternary oxime is also an undesired submicromolar reversible inhibitor of AChE. 1,2,3,4-Tetrahydroacridine 33-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 30125110-3 2018 A promising reactivator based on tetrahydroacridine linked to a nonquaternary oxime is also an undesired submicromolar reversible inhibitor of AChE. Oximes 78-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 30217053-1 2018 Acetylcholinesterase-inhibitory peptide has gained much importance since it can inhibit acetylcholinesterase (AChE) and increase the availability of acetylcholine in cholinergic synapses, enhancing cholinergic transmission in pharmacological treatment of Alzheimer"s disease (AD). Acetylcholine 88-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 30217053-1 2018 Acetylcholinesterase-inhibitory peptide has gained much importance since it can inhibit acetylcholinesterase (AChE) and increase the availability of acetylcholine in cholinergic synapses, enhancing cholinergic transmission in pharmacological treatment of Alzheimer"s disease (AD). Acetylcholine 88-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 30004228-2 2018 This strategy was extended to the preparation of other enantioenriched 1,4-dihydropyridines 1b-i (eight examples), highlighting its potential in the development of these chiral AChE inhibitors. 1,4-dihydropyridines 1b-i 71-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-181 30205495-1 2018 The acetylcholinesterase (AChE) reactivators (e.g., obidoxime, asoxime) became an essential part of organophosphorus (OP) poisoning treatment, together with atropine and diazepam. Obidoxime Chloride 52-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 30205495-1 2018 The acetylcholinesterase (AChE) reactivators (e.g., obidoxime, asoxime) became an essential part of organophosphorus (OP) poisoning treatment, together with atropine and diazepam. Obidoxime Chloride 52-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 30205495-1 2018 The acetylcholinesterase (AChE) reactivators (e.g., obidoxime, asoxime) became an essential part of organophosphorus (OP) poisoning treatment, together with atropine and diazepam. asoxime 63-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 30205495-1 2018 The acetylcholinesterase (AChE) reactivators (e.g., obidoxime, asoxime) became an essential part of organophosphorus (OP) poisoning treatment, together with atropine and diazepam. asoxime 63-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 30205495-1 2018 The acetylcholinesterase (AChE) reactivators (e.g., obidoxime, asoxime) became an essential part of organophosphorus (OP) poisoning treatment, together with atropine and diazepam. organophosphorus 100-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 30205495-1 2018 The acetylcholinesterase (AChE) reactivators (e.g., obidoxime, asoxime) became an essential part of organophosphorus (OP) poisoning treatment, together with atropine and diazepam. organophosphorus 100-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 30205495-1 2018 The acetylcholinesterase (AChE) reactivators (e.g., obidoxime, asoxime) became an essential part of organophosphorus (OP) poisoning treatment, together with atropine and diazepam. Atropine 157-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 30205495-1 2018 The acetylcholinesterase (AChE) reactivators (e.g., obidoxime, asoxime) became an essential part of organophosphorus (OP) poisoning treatment, together with atropine and diazepam. Atropine 157-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 30205495-1 2018 The acetylcholinesterase (AChE) reactivators (e.g., obidoxime, asoxime) became an essential part of organophosphorus (OP) poisoning treatment, together with atropine and diazepam. Diazepam 170-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 30205495-1 2018 The acetylcholinesterase (AChE) reactivators (e.g., obidoxime, asoxime) became an essential part of organophosphorus (OP) poisoning treatment, together with atropine and diazepam. Diazepam 170-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 30205495-5 2018 The novel compounds were prepared, evaluated in vitro on human AChE (HssAChE) inhibited by tabun, paraoxon, methylparaoxon or DFP and compared to commercial HssAChE reactivators (pralidoxime, methoxime, trimedoxime, obidoxime, asoxime) or previously prepared compounds (K048, K074, K075, K203). tabun 91-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 30205495-5 2018 The novel compounds were prepared, evaluated in vitro on human AChE (HssAChE) inhibited by tabun, paraoxon, methylparaoxon or DFP and compared to commercial HssAChE reactivators (pralidoxime, methoxime, trimedoxime, obidoxime, asoxime) or previously prepared compounds (K048, K074, K075, K203). Paraoxon 98-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 30205495-5 2018 The novel compounds were prepared, evaluated in vitro on human AChE (HssAChE) inhibited by tabun, paraoxon, methylparaoxon or DFP and compared to commercial HssAChE reactivators (pralidoxime, methoxime, trimedoxime, obidoxime, asoxime) or previously prepared compounds (K048, K074, K075, K203). methylparaoxon 108-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 30096649-0 2018 Discovery of a potent non-oxime reactivator of nerve agent inhibited human acetylcholinesterase. Oximes 26-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 30096649-1 2018 Organophosphorous (OP) compounds (such as nerve agents) inhibit the enzyme acetylcholinesterase (AChE) by covalent phosphylation of a key serine residue in the active site of the enzyme resulting in severe symptoms and ultimately death. organophosphorous 0-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 30096649-1 2018 Organophosphorous (OP) compounds (such as nerve agents) inhibit the enzyme acetylcholinesterase (AChE) by covalent phosphylation of a key serine residue in the active site of the enzyme resulting in severe symptoms and ultimately death. organophosphorous 0-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 30096649-1 2018 Organophosphorous (OP) compounds (such as nerve agents) inhibit the enzyme acetylcholinesterase (AChE) by covalent phosphylation of a key serine residue in the active site of the enzyme resulting in severe symptoms and ultimately death. Serine 138-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 30096649-1 2018 Organophosphorous (OP) compounds (such as nerve agents) inhibit the enzyme acetylcholinesterase (AChE) by covalent phosphylation of a key serine residue in the active site of the enzyme resulting in severe symptoms and ultimately death. Serine 138-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 30096649-3 2018 The presently fielded oximes reactivate OP-inhibited AChE by liberating the phosphylated serine. Oximes 22-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 30096649-3 2018 The presently fielded oximes reactivate OP-inhibited AChE by liberating the phosphylated serine. Serine 89-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 30096649-6 2018 Recently, a number of non-oxime compounds was discovered in which the 4-amino-2-((diethylamino)methyl)phenol (ADOC) motif proved to be able to reactivate OP-inhibited AChE to some extent. Oximes 26-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 30096649-6 2018 Recently, a number of non-oxime compounds was discovered in which the 4-amino-2-((diethylamino)methyl)phenol (ADOC) motif proved to be able to reactivate OP-inhibited AChE to some extent. 4-amino-2-((diethylamino)methyl)phenol 70-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 30096649-6 2018 Recently, a number of non-oxime compounds was discovered in which the 4-amino-2-((diethylamino)methyl)phenol (ADOC) motif proved to be able to reactivate OP-inhibited AChE to some extent. adoc 110-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 30096649-7 2018 In this paper several structural derivatives of ADOC were synthesized and screened for their ability to reactivate human AChE (hAChE) inhibited by the nerve agents VX, sarin, tabun, cyclosarin and paraoxon. cyclohexyl methylphosphonofluoridate 182-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 30096649-7 2018 In this paper several structural derivatives of ADOC were synthesized and screened for their ability to reactivate human AChE (hAChE) inhibited by the nerve agents VX, sarin, tabun, cyclosarin and paraoxon. cyclohexyl methylphosphonofluoridate 182-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-132 30096649-7 2018 In this paper several structural derivatives of ADOC were synthesized and screened for their ability to reactivate human AChE (hAChE) inhibited by the nerve agents VX, sarin, tabun, cyclosarin and paraoxon. Paraoxon 197-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 30096649-7 2018 In this paper several structural derivatives of ADOC were synthesized and screened for their ability to reactivate human AChE (hAChE) inhibited by the nerve agents VX, sarin, tabun, cyclosarin and paraoxon. Paraoxon 197-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-132 30096649-8 2018 We here disclose that one of those compounds showed a remarkable ability to reactivate OP-inhibited hAChE in vitro and that it is the most potent non-oxime reported to date. Oximes 150-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-105 30187211-0 2018 A colorimetric assay for acetylcholinesterase activity and inhibitor screening based on the thiocholine-induced inhibition of the oxidative power of MnO2 nanosheets on 3,3",5,5"-tetramethylbenzidine. Thiocholine 92-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 30187211-4 2018 If AChE hydrolyzes its substrate acetylthiocholine chloride, thiocholine is formed which blocks the oxidative power of the MnO2 nanosheets. Acetylthiocholine chloride 33-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 3-7 30187211-4 2018 If AChE hydrolyzes its substrate acetylthiocholine chloride, thiocholine is formed which blocks the oxidative power of the MnO2 nanosheets. Thiocholine 39-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 3-7 30187211-4 2018 If AChE hydrolyzes its substrate acetylthiocholine chloride, thiocholine is formed which blocks the oxidative power of the MnO2 nanosheets. manganese dioxide 123-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 3-7 30187211-9 2018 Graphical abstract Based on the oxidizing properties of manganese dioxide nanosheets (MnO2 nanosheets), we report a colorimetric method for determining acetylcholinesterase activity with the chromogenic substrate 3,3",5,5"-tetramethylbenzidine (TMB). manganese dioxide 56-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 30187211-9 2018 Graphical abstract Based on the oxidizing properties of manganese dioxide nanosheets (MnO2 nanosheets), we report a colorimetric method for determining acetylcholinesterase activity with the chromogenic substrate 3,3",5,5"-tetramethylbenzidine (TMB). manganese dioxide 86-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 30187211-9 2018 Graphical abstract Based on the oxidizing properties of manganese dioxide nanosheets (MnO2 nanosheets), we report a colorimetric method for determining acetylcholinesterase activity with the chromogenic substrate 3,3",5,5"-tetramethylbenzidine (TMB). 3,3',5,5'-tetramethylbenzidine 213-243 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 30187211-9 2018 Graphical abstract Based on the oxidizing properties of manganese dioxide nanosheets (MnO2 nanosheets), we report a colorimetric method for determining acetylcholinesterase activity with the chromogenic substrate 3,3",5,5"-tetramethylbenzidine (TMB). 3,3',5,5'-tetramethylbenzidine 245-248 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 30181440-2 2018 AVCRI104P3 is a huprine derivative that exhibits potent inhibitory effects on human AChE, BuChE, and BACE-1 activities, as well as on AChE-induced and self-induced Abeta aggregation. huprine 16-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 30033646-0 2018 Schiff bases and their amines: Synthesis and discovery of carbonic anhydrase and acetylcholinesterase enzymes inhibitors. Schiff Bases 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 30033646-0 2018 Schiff bases and their amines: Synthesis and discovery of carbonic anhydrase and acetylcholinesterase enzymes inhibitors. Amines 23-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 30074266-1 2018 A series of sulfamides were synthesized and evaluated for their acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and carbonic anhydrase inhibition properties. sulfamides 12-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 30074266-1 2018 A series of sulfamides were synthesized and evaluated for their acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and carbonic anhydrase inhibition properties. sulfamides 12-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 30074266-4 2018 The synthesized sulfamide/phenolic sulfamide derivatives were investigated as cholinesterase inhibitors and their relative role in AChE versus BChE inhibition was defined. fusarubin 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 30074266-4 2018 The synthesized sulfamide/phenolic sulfamide derivatives were investigated as cholinesterase inhibitors and their relative role in AChE versus BChE inhibition was defined. phenolic sulfamide 26-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 30079554-3 2018 Monophenyl (16-18) indenoquinolines significantly inhibited the AChE and BChE enzymes in ranges of IC50 37-57 nM and 84-93 nM, respectively, compared with their starting materials 15a-c and reference compounds (galanthamine and tacrine). monophenyl (16-18) indenoquinolines 0-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 30079554-3 2018 Monophenyl (16-18) indenoquinolines significantly inhibited the AChE and BChE enzymes in ranges of IC50 37-57 nM and 84-93 nM, respectively, compared with their starting materials 15a-c and reference compounds (galanthamine and tacrine). Galantamine 211-223 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 30079554-3 2018 Monophenyl (16-18) indenoquinolines significantly inhibited the AChE and BChE enzymes in ranges of IC50 37-57 nM and 84-93 nM, respectively, compared with their starting materials 15a-c and reference compounds (galanthamine and tacrine). Tacrine 228-235 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 29723743-3 2018 Most of the synthesized compounds showed good inhibitory activity, among them, compounds 4d and 4g displayed highest potency against AChE (IC50 1.88 and 1.98 muM), and BChE (IC50 18.32 and 10.21 muM) enzyme, respectively than the standard drug, galanthamine. Galantamine 245-257 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 29775949-0 2018 Design and synthesis of some new carboxamide and propanamide derivatives bearing phenylpyridazine as a core ring and the investigation of their inhibitory potential on in-vitro acetylcholinesterase and butyrylcholinesterase. carboxamide 33-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-197 29775949-0 2018 Design and synthesis of some new carboxamide and propanamide derivatives bearing phenylpyridazine as a core ring and the investigation of their inhibitory potential on in-vitro acetylcholinesterase and butyrylcholinesterase. propionamide 49-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-197 29775949-8 2018 The Lineweaver-Burk plot and docking study showed that compound 5 h targeted both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. cas 109-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 29775949-8 2018 The Lineweaver-Burk plot and docking study showed that compound 5 h targeted both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. Aminosalicylic Acid 147-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 30104121-3 2018 The inhibitory activity of these chromone derivatives against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and carboxylesterase (CaE) was investigated using the methods of enzyme kinetics and molecular docking. Chromones 33-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 30104121-3 2018 The inhibitory activity of these chromone derivatives against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and carboxylesterase (CaE) was investigated using the methods of enzyme kinetics and molecular docking. Chromones 33-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 29992664-0 2018 Novel amides of 1,1-bis-(carboxymethylthio)-1-arylethanes: Synthesis, characterization, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase inhibitory properties. Amides 6-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 29992664-0 2018 Novel amides of 1,1-bis-(carboxymethylthio)-1-arylethanes: Synthesis, characterization, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase inhibitory properties. 1,1-bis-(carboxymethylthio)-1-arylethanes 16-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 29992664-3 2018 These novel amides of 1,1-bis-(carboxymethylthio)-1-arylethanes derivatives showed good inhibitory action against acetylcholinesterase (AChE) butyrylcholinesterase (BChE), and human carbonic anhydrase I and II isoforms (hCA I and II). Amides 12-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 29992664-3 2018 These novel amides of 1,1-bis-(carboxymethylthio)-1-arylethanes derivatives showed good inhibitory action against acetylcholinesterase (AChE) butyrylcholinesterase (BChE), and human carbonic anhydrase I and II isoforms (hCA I and II). Amides 12-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 29992664-3 2018 These novel amides of 1,1-bis-(carboxymethylthio)-1-arylethanes derivatives showed good inhibitory action against acetylcholinesterase (AChE) butyrylcholinesterase (BChE), and human carbonic anhydrase I and II isoforms (hCA I and II). 1,1-bis-(carboxymethylthio)-1-arylethanes 22-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 29992664-3 2018 These novel amides of 1,1-bis-(carboxymethylthio)-1-arylethanes derivatives showed good inhibitory action against acetylcholinesterase (AChE) butyrylcholinesterase (BChE), and human carbonic anhydrase I and II isoforms (hCA I and II). 1,1-bis-(carboxymethylthio)-1-arylethanes 22-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 30031108-6 2018 Cordycepin inhibits ROS production, elevated levels of Ca2+ induced by Abeta25-35, and the activation of acetylcholinesterase; all these are involved in oxidative-induced apoptosis. cordycepin 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 28993240-1 2018 Acetylcholinesterase (AChE) inhibited by the organophosphorus nerve (OP) agent soman underlies a spontaneous and extremely rapid dealkylation ("aging") reaction which prevents reactivation by oximes. Oximes 192-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 28993240-1 2018 Acetylcholinesterase (AChE) inhibited by the organophosphorus nerve (OP) agent soman underlies a spontaneous and extremely rapid dealkylation ("aging") reaction which prevents reactivation by oximes. Oximes 192-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 28993240-5 2018 It turned out that only HI-6 was able to slow down the ongoing inhibition of human AChE by soman without preventing final complete inhibition of the enzyme. asoxime chloride 24-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 28993240-7 2018 In conclusion, the results of the present study indicate a negligible reactivation of soman-inhibited AChE by oximes at conditions simulating the in vivo poisoning by soman. Oximes 110-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 29024789-1 2018 The primary toxic mechanism of organophosphorus compounds, i.e. nerve agents or pesticides, is based on the irreversible inhibition of acetylcholinesterase. Organophosphorus Compounds 31-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 29180286-0 2018 The estimation of oxime efficiency is affected by the experimental design of phosphylated acetylcholinesterase reactivation. Oximes 18-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 30200437-3 2018 The organophosphate pesticide chlorpyrifos (CPF) primarily exerts toxicity through the inhibition of AChE, which results in excess cholinergic stimulation at the synapse. Organophosphates 4-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 29180286-1 2018 Reactivation of acetylcholinesterase (AChE), an essential enzyme in neurotransmission, is a key point in the treatment of acute poisoning by nerve agents and pesticides, which structurally belong to organophosphorus compounds (OP). Organophosphorus Compounds 199-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 30200437-3 2018 The organophosphate pesticide chlorpyrifos (CPF) primarily exerts toxicity through the inhibition of AChE, which results in excess cholinergic stimulation at the synapse. Chlorpyrifos 30-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 30200437-3 2018 The organophosphate pesticide chlorpyrifos (CPF) primarily exerts toxicity through the inhibition of AChE, which results in excess cholinergic stimulation at the synapse. Chlorpyrifos 44-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 29180286-1 2018 Reactivation of acetylcholinesterase (AChE), an essential enzyme in neurotransmission, is a key point in the treatment of acute poisoning by nerve agents and pesticides, which structurally belong to organophosphorus compounds (OP). Organophosphorus Compounds 199-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 29180286-2 2018 Due to the high diversity of substituents on the phosphorous atom, there is a variety of OP-AChE conjugates deriving from AChE inhibition, and therefore not only is there no universal reactivator efficient enough for the most toxic OPs, but for some nerve agents there is still a lack of any reactivator at all. Phosphinidene 49-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 29180286-2 2018 Due to the high diversity of substituents on the phosphorous atom, there is a variety of OP-AChE conjugates deriving from AChE inhibition, and therefore not only is there no universal reactivator efficient enough for the most toxic OPs, but for some nerve agents there is still a lack of any reactivator at all. Phosphinidene 49-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 29180286-3 2018 The endeavor of many chemists to find more efficient reactivators resulted in thousands of newly-designed and synthesized oximes-potential reactivators of AChE. Oximes 122-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 29191791-1 2018 Organophosphorus compounds, including nerve agents and pesticides, exert their toxicity through irreversible inhibition of acetylcholinesterase (AChE) resulting in an accumulation of acetylcholine and functional impairment of muscarinic and nicotinic acetylcholine receptors. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-143 29191791-1 2018 Organophosphorus compounds, including nerve agents and pesticides, exert their toxicity through irreversible inhibition of acetylcholinesterase (AChE) resulting in an accumulation of acetylcholine and functional impairment of muscarinic and nicotinic acetylcholine receptors. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 29191791-1 2018 Organophosphorus compounds, including nerve agents and pesticides, exert their toxicity through irreversible inhibition of acetylcholinesterase (AChE) resulting in an accumulation of acetylcholine and functional impairment of muscarinic and nicotinic acetylcholine receptors. Acetylcholine 123-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 29248576-1 2018 Irreversible inhibition of acetylcholinesterase (AChE) resulting in accumulation of acetylcholine and overstimulation of muscarinic and nicotinic receptors accounts for the acute toxicity of organophosphorus compounds (OP). Acetylcholine 27-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 29248576-1 2018 Irreversible inhibition of acetylcholinesterase (AChE) resulting in accumulation of acetylcholine and overstimulation of muscarinic and nicotinic receptors accounts for the acute toxicity of organophosphorus compounds (OP). Organophosphorus Compounds 191-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 29248576-1 2018 Irreversible inhibition of acetylcholinesterase (AChE) resulting in accumulation of acetylcholine and overstimulation of muscarinic and nicotinic receptors accounts for the acute toxicity of organophosphorus compounds (OP). Organophosphorus Compounds 191-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 29303784-2 2018 Acetylcholinesterase (AChE) is an enzyme that metabolises the ACh at synaptic cleft resulting in Alzheimer"s disease. Acetylcholine 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 30200244-8 2018 The hAChE inhibition by atrazine, propazine, and simazine (the most toxic pesticides) was elucidated by SB quantum mechanics (QM) DFT mechanistic and concentration-dependent kinetic studies, enriching the knowledge for design of less toxic pesticides. Atrazine 24-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-9 30200244-8 2018 The hAChE inhibition by atrazine, propazine, and simazine (the most toxic pesticides) was elucidated by SB quantum mechanics (QM) DFT mechanistic and concentration-dependent kinetic studies, enriching the knowledge for design of less toxic pesticides. propazine 34-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-9 30200244-8 2018 The hAChE inhibition by atrazine, propazine, and simazine (the most toxic pesticides) was elucidated by SB quantum mechanics (QM) DFT mechanistic and concentration-dependent kinetic studies, enriching the knowledge for design of less toxic pesticides. Simazine 49-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-9 29708839-6 2018 beta-ketophosphonate has not been shown to affect most parameters studied, but it strongly reduced AChE activity. beta-ketophosphonate 0-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 30110162-1 2018 Organophosphorus agents such as sarin and soman that phosphylate the active site serine of the enzyme acetylcholinesterase are notorious and pernicious, not only because they have been used by tyrants to effect mass murder of their own populations but also because they are sought by terrorists to inflict mass casualties on civilian populations. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 30110162-1 2018 Organophosphorus agents such as sarin and soman that phosphylate the active site serine of the enzyme acetylcholinesterase are notorious and pernicious, not only because they have been used by tyrants to effect mass murder of their own populations but also because they are sought by terrorists to inflict mass casualties on civilian populations. Serine 81-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 30110162-3 2018 Phosphylation of acetylcholinesterase produces two adducts, an initial neutral adduct that can be reactivated with oxime nucleophiles, and a subsequent monoanionic adduct (called aged acetylcholinesterase) which has proven over two generations to be impervious to reactivation. Oximes 115-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 29772260-0 2018 Oxime-assisted reactivation of tabun-inhibited acetylcholinesterase analysed by active site mutations. Oximes 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 29772260-1 2018 The antidotal property of oximes is attributed to their ability to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP) such as pesticides and nerve warfare agents. Oximes 26-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 29772260-1 2018 The antidotal property of oximes is attributed to their ability to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP) such as pesticides and nerve warfare agents. Oximes 26-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 29772260-1 2018 The antidotal property of oximes is attributed to their ability to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP) such as pesticides and nerve warfare agents. Organophosphorus Compounds 119-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 29772260-1 2018 The antidotal property of oximes is attributed to their ability to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP) such as pesticides and nerve warfare agents. Organophosphorus Compounds 119-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 29772260-7 2018 Therefore, it seems that aromatic amino acids at the peripheral binding site presented a limitation in bispyridinium oxime reactivation efficiency of tabun-phosphorylated AChE. Amino Acids, Aromatic 25-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 29772260-7 2018 Therefore, it seems that aromatic amino acids at the peripheral binding site presented a limitation in bispyridinium oxime reactivation efficiency of tabun-phosphorylated AChE. bispyridinium oxime 103-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 29772260-7 2018 Therefore, it seems that aromatic amino acids at the peripheral binding site presented a limitation in bispyridinium oxime reactivation efficiency of tabun-phosphorylated AChE. tabun 150-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 29777723-0 2018 Effect of acetylcholinesterase inhibitors donepezil and rivastigmine on the activity and expression of cyclooxygenases in a model of the inflammatory action of fluoride on macrophages obtained from THP-1 monocytes. Donepezil 42-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-30 29777723-0 2018 Effect of acetylcholinesterase inhibitors donepezil and rivastigmine on the activity and expression of cyclooxygenases in a model of the inflammatory action of fluoride on macrophages obtained from THP-1 monocytes. Fluorides 160-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-30 29777723-2 2018 Given that acetylcholinesterase inhibitors are also currently believed to have anti-inflammatory properties, the purpose of this study was to investigate the effect of acetylcholinesterase inhibitors (rivastigmine, donepezil) on cyclooxygenase activity and expression using the proinflammatory action of fluoride (F-) on cultured macrophages obtained from THP-1 monocytes. Rivastigmine 201-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 29777723-2 2018 Given that acetylcholinesterase inhibitors are also currently believed to have anti-inflammatory properties, the purpose of this study was to investigate the effect of acetylcholinesterase inhibitors (rivastigmine, donepezil) on cyclooxygenase activity and expression using the proinflammatory action of fluoride (F-) on cultured macrophages obtained from THP-1 monocytes. Rivastigmine 201-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-188 29777723-2 2018 Given that acetylcholinesterase inhibitors are also currently believed to have anti-inflammatory properties, the purpose of this study was to investigate the effect of acetylcholinesterase inhibitors (rivastigmine, donepezil) on cyclooxygenase activity and expression using the proinflammatory action of fluoride (F-) on cultured macrophages obtained from THP-1 monocytes. Donepezil 215-224 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 29777723-2 2018 Given that acetylcholinesterase inhibitors are also currently believed to have anti-inflammatory properties, the purpose of this study was to investigate the effect of acetylcholinesterase inhibitors (rivastigmine, donepezil) on cyclooxygenase activity and expression using the proinflammatory action of fluoride (F-) on cultured macrophages obtained from THP-1 monocytes. Donepezil 215-224 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-188 30110543-1 2018 The enzyme acetylcholinesterase (AChE) is essential in humans and animals because it catalyzes the breakdown of the nerve-signaling substance acetylcholine. Acetylcholine 11-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 29870665-0 2018 Demonstration of In Vitro Resurrection of Aged Acetylcholinesterase after Exposure to Organophosphorus Chemical Nerve Agents. organophosphorus 86-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 29870665-1 2018 After the inhibition of acetylcholinesterase (AChE) by organophosphorus (OP) nerve agents, a dealkylation reaction of the phosphylated serine, referred to as aging, can occur. organophosphorus 55-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 29870665-1 2018 After the inhibition of acetylcholinesterase (AChE) by organophosphorus (OP) nerve agents, a dealkylation reaction of the phosphylated serine, referred to as aging, can occur. organophosphorus 55-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 29870665-1 2018 After the inhibition of acetylcholinesterase (AChE) by organophosphorus (OP) nerve agents, a dealkylation reaction of the phosphylated serine, referred to as aging, can occur. Serine 135-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 29870665-1 2018 After the inhibition of acetylcholinesterase (AChE) by organophosphorus (OP) nerve agents, a dealkylation reaction of the phosphylated serine, referred to as aging, can occur. Serine 135-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 29870665-4 2018 We designed and synthesized a library of quinone methide precursors (QMPs) as proposed realkylators of aged AChE. quinone 41-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 29870665-5 2018 Our lead compound (C8) from an in vitro screen successfully resurrected 32.7 and 20.4% of the activity of methylphosphonate-aged and isopropyl phosphate-aged electric-eel AChE, respectively, after 4 days. Phosphoric acid, 1-methylethyl ester 133-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 29870665-7 2018 Resurrection of methylphosphonate-aged AChE by C8 was significantly pH-dependent, recovering 21% of activity at 4 mM and pH 9 after only 1 day. methylphosphonic acid 16-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 29870665-8 2018 C8 is also effective against isopropyl phosphate-aged human AChE. Phosphoric acid, 1-methylethyl ester 29-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 30568757-5 2018 Molecules 5g and 5a disaggregated AChE-induced (58.26%, 47.36%) Abeta aggregation more than two fold more than the standard drug-donepezil (23.66%) and inhibited Cu2+-induced Abeta aggregation. Donepezil 129-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 30568757-5 2018 Molecules 5g and 5a disaggregated AChE-induced (58.26%, 47.36%) Abeta aggregation more than two fold more than the standard drug-donepezil (23.66%) and inhibited Cu2+-induced Abeta aggregation. cupric ion 162-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 29995397-1 2018 Acetylcholinesterase (AChE, EC 3.1.1.7) is a classical biomarker for monitoring contamination and intoxication of organophosphate (OP) and carbamate pesticides. Organophosphates 114-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 29995397-1 2018 Acetylcholinesterase (AChE, EC 3.1.1.7) is a classical biomarker for monitoring contamination and intoxication of organophosphate (OP) and carbamate pesticides. Organophosphates 114-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 29995397-1 2018 Acetylcholinesterase (AChE, EC 3.1.1.7) is a classical biomarker for monitoring contamination and intoxication of organophosphate (OP) and carbamate pesticides. Carbamates 139-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 29995397-1 2018 Acetylcholinesterase (AChE, EC 3.1.1.7) is a classical biomarker for monitoring contamination and intoxication of organophosphate (OP) and carbamate pesticides. Carbamates 139-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 29995397-3 2018 These emerging organic AChE disruptors include certain persistent organic pollutants (POPs), polycyclic aromatic hydrocarbons (PAHs), and wildly used chemicals, most of which have received considerable public health concern in recent years. POPS 86-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 29995397-3 2018 These emerging organic AChE disruptors include certain persistent organic pollutants (POPs), polycyclic aromatic hydrocarbons (PAHs), and wildly used chemicals, most of which have received considerable public health concern in recent years. Polycyclic Aromatic Hydrocarbons 93-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 29995397-3 2018 These emerging organic AChE disruptors include certain persistent organic pollutants (POPs), polycyclic aromatic hydrocarbons (PAHs), and wildly used chemicals, most of which have received considerable public health concern in recent years. Polycyclic Aromatic Hydrocarbons 127-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 29995397-7 2018 AChE activity in certain organisms has been found to be well correlated with the contamination level of certain persistent pesticides and PAHs in particular habitats. Polycyclic Aromatic Hydrocarbons 138-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 29995397-9 2018 Besides directly inactivating AChE, the mechanisms in terms of interference with the biosynthesis have been recognized for some emerging AChE disruptors, particularly for dioxins. Dioxins 171-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 30025348-1 2018 In this work we describe neurogenic and neuroprotective donepezil-flavonoid hybrids (DFHs), exhibiting nanomolar affinities for the sigma-1 receptor (sigma1R) and inhibition of key enzymes in Alzheimer"s disease (AD), such as acetylcholinesterase (AChE), 5-lipoxygenase (5-LOX), and monoamine oxidases (MAOs). Donepezil 56-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-246 30025348-1 2018 In this work we describe neurogenic and neuroprotective donepezil-flavonoid hybrids (DFHs), exhibiting nanomolar affinities for the sigma-1 receptor (sigma1R) and inhibition of key enzymes in Alzheimer"s disease (AD), such as acetylcholinesterase (AChE), 5-lipoxygenase (5-LOX), and monoamine oxidases (MAOs). Donepezil 56-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 248-252 30025348-1 2018 In this work we describe neurogenic and neuroprotective donepezil-flavonoid hybrids (DFHs), exhibiting nanomolar affinities for the sigma-1 receptor (sigma1R) and inhibition of key enzymes in Alzheimer"s disease (AD), such as acetylcholinesterase (AChE), 5-lipoxygenase (5-LOX), and monoamine oxidases (MAOs). Flavonoids 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-246 30025348-1 2018 In this work we describe neurogenic and neuroprotective donepezil-flavonoid hybrids (DFHs), exhibiting nanomolar affinities for the sigma-1 receptor (sigma1R) and inhibition of key enzymes in Alzheimer"s disease (AD), such as acetylcholinesterase (AChE), 5-lipoxygenase (5-LOX), and monoamine oxidases (MAOs). Flavonoids 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 248-252 30025348-5 2018 Molecular modelling studies of 18 in AChE, 5-LOX and sigma1R revealed the main interactions with these proteins, which will be further exploited in the optimization of new, more efficient DFHs. dfhs 188-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 29778781-5 2018 We also report a significant decrease of the affinity of acetylcholinesterase (AChE) for the substrate in the presence of fullerenol, indicating the relatively strong adsorption of C60(OH)36 to components of plasma membrane. fullerenol 122-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 29778781-5 2018 We also report a significant decrease of the affinity of acetylcholinesterase (AChE) for the substrate in the presence of fullerenol, indicating the relatively strong adsorption of C60(OH)36 to components of plasma membrane. fullerenol 122-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 29614435-6 2018 A series of some novel quinolonederivatives were designed, synthesized, and their inhibitory effects on AChE were evaluated. quinolonederivatives 23-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 29679445-5 2018 The strategy is to obtain an effective mimetic of donepezil, which is acetylcholinesterase inhibitor. Donepezil 50-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 29747078-0 2018 Mechanisms of acetylcholinesterase protection against sarin and soman by adenosine A1 receptor agonist N6-cyclopentyladenosine. N(6)-cyclopentyladenosine 103-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 29747078-1 2018 Organophosphorus nerve agents (NAs) irreversibly inhibit acetylcholinesterase (AChE), the enzyme responsible for breaking down the neurotransmitter acetylcholine (ACh). organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 29747078-1 2018 Organophosphorus nerve agents (NAs) irreversibly inhibit acetylcholinesterase (AChE), the enzyme responsible for breaking down the neurotransmitter acetylcholine (ACh). organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 29747078-1 2018 Organophosphorus nerve agents (NAs) irreversibly inhibit acetylcholinesterase (AChE), the enzyme responsible for breaking down the neurotransmitter acetylcholine (ACh). Acetylcholine 57-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 29747078-1 2018 Organophosphorus nerve agents (NAs) irreversibly inhibit acetylcholinesterase (AChE), the enzyme responsible for breaking down the neurotransmitter acetylcholine (ACh). Acetylcholine 79-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 29747078-4 2018 Alternative acute treatment with the adenosine A1 receptor agonist N6-cyclopentyladensosine (CPA) has previously been demonstrated to prevent AChE inhibition as well as to suppress neuronal activity. n6-cyclopentyladensosine 67-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 29747078-4 2018 Alternative acute treatment with the adenosine A1 receptor agonist N6-cyclopentyladensosine (CPA) has previously been demonstrated to prevent AChE inhibition as well as to suppress neuronal activity. cpa 93-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 29747078-6 2018 To elucidate the feasibility of potential CPA-AChE interaction mechanisms, we applied a truncated molecular model approach and density functional theory. cpa 42-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 29747078-8 2018 Our thermodynamic data suggest that CPA can compete with the NAs sarin and soman for the active site of AChE, but may, in contrast to NAs, undergo back-reaction. cpa 36-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 29747078-9 2018 We found a strong interaction between CPA and NA conjugated AChE, making enzyme reactivation unlikely but possibly allowing for CPA protection through the prevention of NA aging. cpa 38-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 29747078-9 2018 We found a strong interaction between CPA and NA conjugated AChE, making enzyme reactivation unlikely but possibly allowing for CPA protection through the prevention of NA aging. cpa 128-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 29516527-1 2018 Despite the main mechanism of organophosphate (OP) toxicity through inhibition of acetylcholinesterase (AChE) being well known over the years, some chronic adverse health effects indicate the involvement of additional pathways. Organophosphates 30-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 29516527-1 2018 Despite the main mechanism of organophosphate (OP) toxicity through inhibition of acetylcholinesterase (AChE) being well known over the years, some chronic adverse health effects indicate the involvement of additional pathways. Organophosphates 30-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 29975450-0 2018 Intermolecular amination of allylic and benzylic alcohols leads to effective inhibitions of acetylcholinesterase enzyme and carbonic anhydrase I and II isoenzymes. Alcohols 49-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 29431576-5 2018 The AChE inhibitory activity of RA was reduced by ~57% in the presence of BSA, while the antioxidant activity increased. rosmarinic acid 32-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 29675901-1 2018 Acetylcholinesterase (AChE; EC 3.1.1.7) is known to hydrolyze acetylcholine at cholinergic synapses. Acetylcholine 62-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 29675901-1 2018 Acetylcholinesterase (AChE; EC 3.1.1.7) is known to hydrolyze acetylcholine at cholinergic synapses. Acetylcholine 62-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 30008113-2 2018 The rapid hydrolysis of the principal neurotransmitter into choline and acetate by acetylcholinesterase (AChE) at synapses causes the loss of cognitive response that becomes the real cause of AD. Choline 60-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 29307532-0 2018 Analysis of acetylcholinesterase inhibitors by extraction in choline saccharinate aqueous biphasic systems. choline saccharinate 61-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 29652131-0 2018 Thioflavin T Interaction with Acetylcholinesterase: New Evidence of 1:1 Binding Stoichiometry Obtained with Samples Prepared by Equilibrium Microdialysis. thioflavin T 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 29652131-1 2018 The aim of the present work was investigation of the fluorescent dye thioflavin T (ThT) binding to acetylcholinesterase (AChE). thioflavin T 69-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 29652131-1 2018 The aim of the present work was investigation of the fluorescent dye thioflavin T (ThT) binding to acetylcholinesterase (AChE). thioflavin T 69-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 29652131-1 2018 The aim of the present work was investigation of the fluorescent dye thioflavin T (ThT) binding to acetylcholinesterase (AChE). thioflavin T 83-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 29652131-1 2018 The aim of the present work was investigation of the fluorescent dye thioflavin T (ThT) binding to acetylcholinesterase (AChE). thioflavin T 83-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 29652131-3 2018 Despite the extended and active investigation of ThT-AChE binding, there is still no common view on the stoichiometry of this interaction. thioflavin T 49-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 29652131-4 2018 In particular, there is a hypothesis explaining the spectral properties of bound to AChE dye and high quantum yield of its fluorescence by formation of dimers or excimers of ThT. thioflavin T 174-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 29652131-5 2018 In order to confirm or deny this hypothesis, we proposed a new experimental approach for examination of ThT-AChE interaction based on spectroscopic investigation of samples prepared by equilibrium microdialysis. thioflavin T 104-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 29652131-6 2018 This approach allowed us to prove 1/1 ThT/AChE binding stoichiometry. thioflavin T 38-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 29652131-7 2018 The increase of ThT fluorescence quantum yield and lifetime accompanying its binding to AChE can be explained by the molecular rotor nature of this dye. thioflavin T 16-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 29652131-8 2018 Together with the coincidence of the positions of free and AChE-bound ThT fluorescence spectra, the obtained results prove the groundlessness of the hypotheses about ThT aggregation while binding to AChE. thioflavin T 70-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 29652131-8 2018 Together with the coincidence of the positions of free and AChE-bound ThT fluorescence spectra, the obtained results prove the groundlessness of the hypotheses about ThT aggregation while binding to AChE. thioflavin T 70-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-203 29652131-8 2018 Together with the coincidence of the positions of free and AChE-bound ThT fluorescence spectra, the obtained results prove the groundlessness of the hypotheses about ThT aggregation while binding to AChE. thioflavin T 166-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 29652131-9 2018 The model of ThT localization in the active site of AChE was proposed by using molecular docking simulations. thioflavin T 13-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 29652131-10 2018 These results also allowed us to suggest the key role of aromatic residues in ThT-AChE interaction, as observed for some amyloid fibrils. thioflavin T 78-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 29886321-2 2018 Starting from potent pseudo-irreversible quinolinium salts AChE inhibitors 2 previously reported, a new set of diversely substituted quinolinium salts 2a-p was prepared and assayed for their inhibitory activity against AChE. quinolinium salts 2a-p 133-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 29886321-2 2018 Starting from potent pseudo-irreversible quinolinium salts AChE inhibitors 2 previously reported, a new set of diversely substituted quinolinium salts 2a-p was prepared and assayed for their inhibitory activity against AChE. quinolinium salts 2a-p 133-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 219-223 29886321-6 2018 Pleasingly, whereas compound 4 showed to be a highly potent inhibitor of AChE (IC50 = 6 nM) and binds to AChE-PAS to the same extent as donepezil, its prodrug 3 revealed to be inactive (IC50 > 10 muM). Aminosalicylic Acid 110-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 29886321-7 2018 These preliminary results constitute one of the few examples of carbamate-based dual binding site AChE inhibitors. Carbamates 64-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 30008113-2 2018 The rapid hydrolysis of the principal neurotransmitter into choline and acetate by acetylcholinesterase (AChE) at synapses causes the loss of cognitive response that becomes the real cause of AD. Choline 60-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 30008113-2 2018 The rapid hydrolysis of the principal neurotransmitter into choline and acetate by acetylcholinesterase (AChE) at synapses causes the loss of cognitive response that becomes the real cause of AD. Acetates 72-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 30008113-2 2018 The rapid hydrolysis of the principal neurotransmitter into choline and acetate by acetylcholinesterase (AChE) at synapses causes the loss of cognitive response that becomes the real cause of AD. Acetates 72-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 30008113-4 2018 In this context, we designed and performed molecular recognitions studies of coumarin-based inhibitors towards AChE. coumarin 77-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 29742314-4 2018 This article focuses on the history and recent advances of benzofuran- and indole-based compounds as inhibitors of butyrylcholinesterase, acetylcholinesterase, gamma-secretase, beta-secretase, tau misfolding, and beta-amyloid aggregation. benzofuran 59-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 29742314-4 2018 This article focuses on the history and recent advances of benzofuran- and indole-based compounds as inhibitors of butyrylcholinesterase, acetylcholinesterase, gamma-secretase, beta-secretase, tau misfolding, and beta-amyloid aggregation. indole 75-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 29870588-6 2018 The most active compound 3d (IC50 = 7.6 pM for AChE and 1.7 pM for BuChE) appeared to be a much more active inhibitor than tacrine (IC50 = 89.9 nM for AChE and 14.9 nM for BuChE). Tacrine 124-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 29984517-4 2018 Additionally, the most active 16 compounds against AChE/BuChE were chosen to investigate the neuroprotective effects, and the results indicated that most of the compounds have free radical scavenging properties and show their effects by reducing free radical production; moreover, some of the compounds significantly increased the viability of SH-SY5Y cells exposed to H2 O2 . Free Radicals 176-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 29984517-4 2018 Additionally, the most active 16 compounds against AChE/BuChE were chosen to investigate the neuroprotective effects, and the results indicated that most of the compounds have free radical scavenging properties and show their effects by reducing free radical production; moreover, some of the compounds significantly increased the viability of SH-SY5Y cells exposed to H2 O2 . Hydrogen Peroxide 369-374 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 29893118-0 2018 Acetylcholinesterase and Abeta Aggregation Inhibition by Heterometallic Ruthenium(II)-Platinum(II) Polypyridyl Complexes. ruthenium(ii)-platinum(ii) polypyridyl complexes 72-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 29870588-6 2018 The most active compound 3d (IC50 = 7.6 pM for AChE and 1.7 pM for BuChE) appeared to be a much more active inhibitor than tacrine (IC50 = 89.9 nM for AChE and 14.9 nM for BuChE). Tacrine 124-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 29963738-0 2018 meta-Cyanobenzyl substituted benzimidazolium salts: Synthesis, characterization, crystal structure and carbonic anhydrase, alpha-glycosidase, butyrylcholinesterase, and acetylcholinesterase inhibitory properties. meta-cyanobenzyl substituted benzimidazolium salts 0-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-189 30189733-8 2018 Key words: acetylcholinesterase Alzheimer"s disease antioxidant butyrylcholinesterase melatonin neurodegenerative disorders. Melatonin 94-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 29752732-4 2018 One of the compounds with spiro 1,3-cyclohexanedione moiety (7) possessed moderate acetylcholinesterase inhibitory activity, while 3 showed neuroprotective activity in oxygen-glucose deprivation-induced neurotoxicity in human neuroblastoma SH-SY5Y cells. spiro 1,3-cyclohexanedione 26-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 29926988-2 2018 Galantamine, an acetylcholinesterase inhibitor, may reduce cigarette smoking in otherwise healthy treatment-seeking smokers. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 30127816-1 2018 Chlorpyrifos (CP), an acetylcholinesterase (AChE) inhibitor, is used throughout the world as an insecticide in agriculture and an eradicating agent for termites around homes. Chlorpyrifos 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 30127816-9 2018 Besides, ZnO NPs increased the levels of AChE and TAP at 1 microg/mL. Zinc Oxide 9-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 29980922-0 2018 Influence of gauche effect on uncharged oxime reactivators for the reactivation of tabun-inhibited AChE: quantum chemical and steered molecular dynamics studies. Oximes 40-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 29980922-1 2018 The neutral oxime reactivator RS194B with a seven-membered ring has shown better efficacy towards the tabun-inhibited AChE than that of RS69N with a six-membered ring and RS41A with a five-membered ring. Oximes 12-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 29980922-5 2018 The SMD simulations show that RS194B retains in more stable gauche conformation inside the active gorge of AChE during different time intervals that experiences more hydrogen bonding, hydrophobic interactions with the catalytic anionic site (CAS) residues and weaker interactions with the peripheral anionic site (PAS) residues compared to RS41A and RS69N. Hydrogen 166-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 29980922-5 2018 The SMD simulations show that RS194B retains in more stable gauche conformation inside the active gorge of AChE during different time intervals that experiences more hydrogen bonding, hydrophobic interactions with the catalytic anionic site (CAS) residues and weaker interactions with the peripheral anionic site (PAS) residues compared to RS41A and RS69N. Aminosalicylic Acid 314-317 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 29777723-2 2018 Given that acetylcholinesterase inhibitors are also currently believed to have anti-inflammatory properties, the purpose of this study was to investigate the effect of acetylcholinesterase inhibitors (rivastigmine, donepezil) on cyclooxygenase activity and expression using the proinflammatory action of fluoride (F-) on cultured macrophages obtained from THP-1 monocytes. Fluorides 304-312 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-188 29797194-1 2018 Acetylcholinesterase (AChE) acts on the hydrolysis of acetylcholine, rapidly removing this neurotransmitter at cholinergic synapses and neuromuscular junctions as well as in neuronal growth and differentiation, modulation of cell adhesion ("electrotactins") and aryl-acylamidase activity (AAA). Acetylcholine 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 29797194-1 2018 Acetylcholinesterase (AChE) acts on the hydrolysis of acetylcholine, rapidly removing this neurotransmitter at cholinergic synapses and neuromuscular junctions as well as in neuronal growth and differentiation, modulation of cell adhesion ("electrotactins") and aryl-acylamidase activity (AAA). Acetylcholine 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 29797194-4 2018 Here, a review on erythrocyte AChE characteristics and use as biomarker for organophosphorus and carbamate insecticides is presented since it is the first specific target/barrier of the action of these pesticides, besides plasma butyrylcholinesterase (BChE). organophosphorus 76-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 29797194-4 2018 Here, a review on erythrocyte AChE characteristics and use as biomarker for organophosphorus and carbamate insecticides is presented since it is the first specific target/barrier of the action of these pesticides, besides plasma butyrylcholinesterase (BChE). Carbamates 97-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 29614332-3 2018 Treatment for toxicity due to OPC exposure has been largely focused on the reactivation of AChE by oxime-based compounds via direct nucleophilic attack on the phosphorous center. opc 30-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 29614332-3 2018 Treatment for toxicity due to OPC exposure has been largely focused on the reactivation of AChE by oxime-based compounds via direct nucleophilic attack on the phosphorous center. Oximes 99-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 29773682-0 2018 Water structure changes in oxime-mediated reactivation process of phosphorylated human acetylcholinesterase. Water 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 29773682-0 2018 Water structure changes in oxime-mediated reactivation process of phosphorylated human acetylcholinesterase. Oximes 27-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 29773682-2 2018 To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-). Water 23-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 29773682-2 2018 To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-). Water 23-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 29773682-2 2018 To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-). Paraoxon 81-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 29773682-2 2018 To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-). Paraoxon 81-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 29773682-2 2018 To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-). Oximes 155-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 29773682-2 2018 To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-). Oximes 155-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 29773682-2 2018 To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-). asoxime 161-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 29773682-2 2018 To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-). asoxime 161-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 29773682-2 2018 To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-). asoxime chloride 170-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 29938351-0 2018 Crystal structure, DFT calculations and evaluation of 2-(2-(3,4-dimethoxyphenyl)ethyl)isoindoline-1,3-dione as AChE inhibitor. 2-[2-(3,4-dimethoxyphenyl)ethyl]-1H-isoindole-1,3(2H)-dione 54-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 29938351-2 2018 Various reports have shown that phthalimide derivatives are potent inhibitors of AChE, a key enzyme involved in the deterioration of the cholinergic system during the development of Alzheimer"s disease. phthalimide 32-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 29938351-3 2018 In the present study, 2-(2-(3,4-dimethoxyphenyl)ethyl)isoindoline-1,3-dione was synthesized, crystallized and evaluated as an AChE inhibitor. 2-[2-(3,4-dimethoxyphenyl)ethyl]-1H-isoindole-1,3(2H)-dione 22-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 29938351-6 2018 Finally, the biological experiments reveal that the isoindoline-1,3-dione exerts a good competitive inhibition on AChE (Ki = 0.33-0.93 mM; 95% confidence interval) and has very low acute toxicity (LD50 > 1600 mg/kg) compared to the AChE inhibitors currently approved for clinical use. isoindoline-1,3-dione 52-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 29938351-6 2018 Finally, the biological experiments reveal that the isoindoline-1,3-dione exerts a good competitive inhibition on AChE (Ki = 0.33-0.93 mM; 95% confidence interval) and has very low acute toxicity (LD50 > 1600 mg/kg) compared to the AChE inhibitors currently approved for clinical use. isoindoline-1,3-dione 52-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 235-239 29932100-6 2018 Based on the biological evaluation, hesperidin demonstrated the best inhibitory properties toward BACE1, AChE, and BChE, with IC50 values of 10.02 +- 1.12, 22.80 +- 2.78, and 48.09 +- 0.74 &micro;M, respectively. Hesperidin 36-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 29684530-7 2018 The clinical phosphodiesterase type-3 inhibitor cilostazol (CSZ) was recently found to suppress the progression of cognitive decline in patients with stable AD receiving acetylcholinesterase inhibitors. Cilostazol 48-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-190 29684530-7 2018 The clinical phosphodiesterase type-3 inhibitor cilostazol (CSZ) was recently found to suppress the progression of cognitive decline in patients with stable AD receiving acetylcholinesterase inhibitors. Cilostazol 60-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-190 29977295-0 2018 Fabrication of AChE/SnO2-cMWCNTs/Cu Nanocomposite-Based Sensor Electrode for Detection of Methyl Parathion in Water. Methyl Parathion 90-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 29977295-0 2018 Fabrication of AChE/SnO2-cMWCNTs/Cu Nanocomposite-Based Sensor Electrode for Detection of Methyl Parathion in Water. Water 110-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 29977295-1 2018 The work highlights inhibition-based Acetylcholinesterase (AChE) fabrication using composite nanomaterial comprising tin oxide nanoparticles (SnO2) and carboxylated multiwalled carbon nanotubes (cMWCNTs) for detection of pesticide methyl parathion (MP) in water samples. stannic oxide 117-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 29977295-1 2018 The work highlights inhibition-based Acetylcholinesterase (AChE) fabrication using composite nanomaterial comprising tin oxide nanoparticles (SnO2) and carboxylated multiwalled carbon nanotubes (cMWCNTs) for detection of pesticide methyl parathion (MP) in water samples. stannic oxide 117-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 29977295-1 2018 The work highlights inhibition-based Acetylcholinesterase (AChE) fabrication using composite nanomaterial comprising tin oxide nanoparticles (SnO2) and carboxylated multiwalled carbon nanotubes (cMWCNTs) for detection of pesticide methyl parathion (MP) in water samples. Tin(IV) oxide 142-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 29977295-1 2018 The work highlights inhibition-based Acetylcholinesterase (AChE) fabrication using composite nanomaterial comprising tin oxide nanoparticles (SnO2) and carboxylated multiwalled carbon nanotubes (cMWCNTs) for detection of pesticide methyl parathion (MP) in water samples. Tin(IV) oxide 142-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 29977295-1 2018 The work highlights inhibition-based Acetylcholinesterase (AChE) fabrication using composite nanomaterial comprising tin oxide nanoparticles (SnO2) and carboxylated multiwalled carbon nanotubes (cMWCNTs) for detection of pesticide methyl parathion (MP) in water samples. Carbon 177-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 29977295-1 2018 The work highlights inhibition-based Acetylcholinesterase (AChE) fabrication using composite nanomaterial comprising tin oxide nanoparticles (SnO2) and carboxylated multiwalled carbon nanotubes (cMWCNTs) for detection of pesticide methyl parathion (MP) in water samples. Carbon 177-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 29977295-1 2018 The work highlights inhibition-based Acetylcholinesterase (AChE) fabrication using composite nanomaterial comprising tin oxide nanoparticles (SnO2) and carboxylated multiwalled carbon nanotubes (cMWCNTs) for detection of pesticide methyl parathion (MP) in water samples. Methyl Parathion 231-247 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 29977295-1 2018 The work highlights inhibition-based Acetylcholinesterase (AChE) fabrication using composite nanomaterial comprising tin oxide nanoparticles (SnO2) and carboxylated multiwalled carbon nanotubes (cMWCNTs) for detection of pesticide methyl parathion (MP) in water samples. Methyl Parathion 231-247 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 29977295-1 2018 The work highlights inhibition-based Acetylcholinesterase (AChE) fabrication using composite nanomaterial comprising tin oxide nanoparticles (SnO2) and carboxylated multiwalled carbon nanotubes (cMWCNTs) for detection of pesticide methyl parathion (MP) in water samples. Water 256-261 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 29977295-1 2018 The work highlights inhibition-based Acetylcholinesterase (AChE) fabrication using composite nanomaterial comprising tin oxide nanoparticles (SnO2) and carboxylated multiwalled carbon nanotubes (cMWCNTs) for detection of pesticide methyl parathion (MP) in water samples. Water 256-261 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 29977295-2 2018 Working electrode AChE/SnO2-cMWCNTs/Cu exhibited high sensitivity with a linearity range of 1.0 muM to 160 muM and a minimum detection limit of 0.1 muM for MP in water. Water 162-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 29977295-5 2018 The enzyme AChE was covalently immobilized with cMWCNTs using glutaraldehyde as crosslinking agent which has enhanced the storage stability and reusability of the method. cmwcnts 48-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-15 29977295-5 2018 The enzyme AChE was covalently immobilized with cMWCNTs using glutaraldehyde as crosslinking agent which has enhanced the storage stability and reusability of the method. Glutaral 62-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-15 29977295-7 2018 Also, AChE/SnO2-cMWCNTs/Cu was easily reactivated simply by varying pH of phosphate buffer. Phosphates 74-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 29635172-2 2018 In the present study, a surface plasmon resonance (SPR)-based assay was developed and employed to investigate interactions between human recombinant AChE (hAChE) and four known ligands: galantamine, tacrine, donepezil and edrophonium. Galantamine 186-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 29635172-2 2018 In the present study, a surface plasmon resonance (SPR)-based assay was developed and employed to investigate interactions between human recombinant AChE (hAChE) and four known ligands: galantamine, tacrine, donepezil and edrophonium. Tacrine 199-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 29635172-2 2018 In the present study, a surface plasmon resonance (SPR)-based assay was developed and employed to investigate interactions between human recombinant AChE (hAChE) and four known ligands: galantamine, tacrine, donepezil and edrophonium. Donepezil 208-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 29635172-2 2018 In the present study, a surface plasmon resonance (SPR)-based assay was developed and employed to investigate interactions between human recombinant AChE (hAChE) and four known ligands: galantamine, tacrine, donepezil and edrophonium. Edrophonium 222-233 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 29745222-0 2018 New Flavone-Cyanoacetamide Hybrids with a Combination of Cholinergic, Antioxidant, Modulation of beta-Amyloid Aggregation, and Neuroprotection Properties as Innovative Multifunctional Therapeutic Candidates for Alzheimer"s Disease and Unraveling Their Mechanism of Action with Acetylcholinesterase. flavone 4-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 277-297 29745222-0 2018 New Flavone-Cyanoacetamide Hybrids with a Combination of Cholinergic, Antioxidant, Modulation of beta-Amyloid Aggregation, and Neuroprotection Properties as Innovative Multifunctional Therapeutic Candidates for Alzheimer"s Disease and Unraveling Their Mechanism of Action with Acetylcholinesterase. 2-cyanoacetamide 12-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 277-297 29655025-7 2018 Molecular docking studies indicated that the binding mode of the compound 5f share common characteristics with the galantamine/donepezil-AChE complexes. Galantamine 115-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 29773682-2 2018 To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-). asoxime chloride 170-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 29773682-2 2018 To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-). Salts 233-237 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 29773682-2 2018 To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-). Salts 233-237 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 29773682-2 2018 To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-). Sodium Chloride 256-260 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 29773682-2 2018 To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-). Sodium Chloride 256-260 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 29773682-2 2018 To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-). Salts 250-254 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 29773682-2 2018 To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-). Salts 250-254 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 29773682-2 2018 To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-). liscn 289-294 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 29773682-2 2018 To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-). liscn 289-294 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 29773682-2 2018 To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-). Ammonium Sulfate 326-343 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 29773682-2 2018 To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-). Ammonium Sulfate 326-343 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 29773682-2 2018 To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-). Phosphates 348-357 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 29773682-2 2018 To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-). Phosphates 348-357 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 29773682-2 2018 To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-). hpo42 358-363 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 29773682-2 2018 To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-). hpo42 358-363 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 29773682-4 2018 Reactivation kinetics showed that the low concentration of chaotropic salt up to 75 mM increased the percentage of reactivation of diethylphosphorylated AChE whereas kosmotropic salts lead only to a small decrease in reactivation. Salts 70-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 29655025-7 2018 Molecular docking studies indicated that the binding mode of the compound 5f share common characteristics with the galantamine/donepezil-AChE complexes. Donepezil 127-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 29567174-1 2018 A highly sensitive electrochemical biosensor based on the synthetized L-Cysteine-Ag(I) coordination polymer (L-Cys-Ag(I) CP), which looks like a protein-mimicking nanowire, was constructed to detect acetylcholinesterase (AChE) activity and screen its inhibitors. l-cysteine-ag 70-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-219 29567153-0 2018 A novel amperometric biosensor based on covalently attached multilayer assemblies of gold nanoparticles, diazo-resins and acetylcholinesterase for the detection of organophosphorus pesticides. organophosphorus 164-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-142 29567179-4 2018 The detection mechanism monitors the inhibition of the activity of acetylcholinesterase (AChE) by the pesticide, in which the production of thiocholine from the hydrolysis of acetylthiocholine (ATCh) catalyzed by AChE is reduced. Acetylthiocholine 194-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 29567179-4 2018 The detection mechanism monitors the inhibition of the activity of acetylcholinesterase (AChE) by the pesticide, in which the production of thiocholine from the hydrolysis of acetylthiocholine (ATCh) catalyzed by AChE is reduced. Acetylthiocholine 194-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 29567179-4 2018 The detection mechanism monitors the inhibition of the activity of acetylcholinesterase (AChE) by the pesticide, in which the production of thiocholine from the hydrolysis of acetylthiocholine (ATCh) catalyzed by AChE is reduced. Acetylthiocholine 194-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-217 29763808-4 2018 In particular, compound 11 which was the most potent AChE inhibitor showed good inhibitory effect on Abeta-aggregation and intracellular ROS (reactive oxygen species) formation, as well as the ability of selective bio-metal chelation and neuroprotection against H2O2- and Abeta1-42-induced cytotoxicity. Reactive Oxygen Species 137-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 29763808-4 2018 In particular, compound 11 which was the most potent AChE inhibitor showed good inhibitory effect on Abeta-aggregation and intracellular ROS (reactive oxygen species) formation, as well as the ability of selective bio-metal chelation and neuroprotection against H2O2- and Abeta1-42-induced cytotoxicity. Reactive Oxygen Species 142-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 29763808-4 2018 In particular, compound 11 which was the most potent AChE inhibitor showed good inhibitory effect on Abeta-aggregation and intracellular ROS (reactive oxygen species) formation, as well as the ability of selective bio-metal chelation and neuroprotection against H2O2- and Abeta1-42-induced cytotoxicity. Metals 218-223 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 29763808-4 2018 In particular, compound 11 which was the most potent AChE inhibitor showed good inhibitory effect on Abeta-aggregation and intracellular ROS (reactive oxygen species) formation, as well as the ability of selective bio-metal chelation and neuroprotection against H2O2- and Abeta1-42-induced cytotoxicity. Hydrogen Peroxide 262-266 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 29664277-1 2018 Nerve agents are organophosphorus chemical warfare agents that exert their action through the irreversible inhibition of acetylcholinesterase, with a consequent overstimulation of cholinergic transmission followed by its shutdown. organophosphorus 17-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 29550345-1 2018 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are key cholinesterase enzymes responsible for the hydrolysis of acetylcholine into choline and acetic acid, an essential process for the restoration of the cholinergic neuron. Acetylcholine 126-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 29550345-1 2018 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are key cholinesterase enzymes responsible for the hydrolysis of acetylcholine into choline and acetic acid, an essential process for the restoration of the cholinergic neuron. Acetylcholine 126-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 29550345-1 2018 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are key cholinesterase enzymes responsible for the hydrolysis of acetylcholine into choline and acetic acid, an essential process for the restoration of the cholinergic neuron. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 29550345-1 2018 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are key cholinesterase enzymes responsible for the hydrolysis of acetylcholine into choline and acetic acid, an essential process for the restoration of the cholinergic neuron. Acetic Acid 157-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 29550345-1 2018 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are key cholinesterase enzymes responsible for the hydrolysis of acetylcholine into choline and acetic acid, an essential process for the restoration of the cholinergic neuron. Acetic Acid 157-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 29754165-0 2018 Amperometric determination of As(III) and Cd(II) using a platinum electrode modified with acetylcholinesterase, ruthenium(II)-tris(bipyridine) and graphene oxide. as(iii) 30-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 29567174-1 2018 A highly sensitive electrochemical biosensor based on the synthetized L-Cysteine-Ag(I) coordination polymer (L-Cys-Ag(I) CP), which looks like a protein-mimicking nanowire, was constructed to detect acetylcholinesterase (AChE) activity and screen its inhibitors. l-cysteine-ag 70-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 221-225 29567174-1 2018 A highly sensitive electrochemical biosensor based on the synthetized L-Cysteine-Ag(I) coordination polymer (L-Cys-Ag(I) CP), which looks like a protein-mimicking nanowire, was constructed to detect acetylcholinesterase (AChE) activity and screen its inhibitors. Cysteine 72-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-219 29567174-1 2018 A highly sensitive electrochemical biosensor based on the synthetized L-Cysteine-Ag(I) coordination polymer (L-Cys-Ag(I) CP), which looks like a protein-mimicking nanowire, was constructed to detect acetylcholinesterase (AChE) activity and screen its inhibitors. Cysteine 72-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 221-225 29567174-2 2018 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce hydrogen peroxide (H2O2), thus L-Cys-Ag(I) CP possesses the electro-catalytic property to H2O2 reduction. Acetylcholine 47-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 29567174-2 2018 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce hydrogen peroxide (H2O2), thus L-Cys-Ag(I) CP possesses the electro-catalytic property to H2O2 reduction. Acetylcholine 47-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 29567174-2 2018 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce hydrogen peroxide (H2O2), thus L-Cys-Ag(I) CP possesses the electro-catalytic property to H2O2 reduction. Acetylcholine 71-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 29567174-2 2018 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce hydrogen peroxide (H2O2), thus L-Cys-Ag(I) CP possesses the electro-catalytic property to H2O2 reduction. Acetylcholine 71-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 29567174-2 2018 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce hydrogen peroxide (H2O2), thus L-Cys-Ag(I) CP possesses the electro-catalytic property to H2O2 reduction. Choline 53-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 29567174-2 2018 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce hydrogen peroxide (H2O2), thus L-Cys-Ag(I) CP possesses the electro-catalytic property to H2O2 reduction. Choline 53-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 29567174-2 2018 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce hydrogen peroxide (H2O2), thus L-Cys-Ag(I) CP possesses the electro-catalytic property to H2O2 reduction. Hydrogen Peroxide 201-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 29567174-2 2018 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce hydrogen peroxide (H2O2), thus L-Cys-Ag(I) CP possesses the electro-catalytic property to H2O2 reduction. Hydrogen Peroxide 201-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 29567174-2 2018 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce hydrogen peroxide (H2O2), thus L-Cys-Ag(I) CP possesses the electro-catalytic property to H2O2 reduction. Hydrogen Peroxide 220-224 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 29567174-2 2018 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce hydrogen peroxide (H2O2), thus L-Cys-Ag(I) CP possesses the electro-catalytic property to H2O2 reduction. Hydrogen Peroxide 220-224 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 29567174-2 2018 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce hydrogen peroxide (H2O2), thus L-Cys-Ag(I) CP possesses the electro-catalytic property to H2O2 reduction. Cysteine 232-237 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 29567174-2 2018 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce hydrogen peroxide (H2O2), thus L-Cys-Ag(I) CP possesses the electro-catalytic property to H2O2 reduction. Cysteine 232-237 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 29567174-2 2018 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce hydrogen peroxide (H2O2), thus L-Cys-Ag(I) CP possesses the electro-catalytic property to H2O2 reduction. Hydrogen Peroxide 291-295 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 29567174-2 2018 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce hydrogen peroxide (H2O2), thus L-Cys-Ag(I) CP possesses the electro-catalytic property to H2O2 reduction. Hydrogen Peroxide 291-295 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 29567174-3 2018 Herein, the protein-mimicking nanowire-based platform was capable of investigating successive of H2O2 effectively by amperometric i-t (current-time) response, and was further applied for the turn-on electrochemical detection of AChE activity. Hydrogen Peroxide 97-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 228-232 29567174-5 2018 The model for AChE inhibition was further established and two traditional AChE inhibitors (donepezil and tacrine) were employed to verify the feasibility of the system. Tacrine 105-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 29567179-4 2018 The detection mechanism monitors the inhibition of the activity of acetylcholinesterase (AChE) by the pesticide, in which the production of thiocholine from the hydrolysis of acetylthiocholine (ATCh) catalyzed by AChE is reduced. Thiocholine 140-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 29567179-4 2018 The detection mechanism monitors the inhibition of the activity of acetylcholinesterase (AChE) by the pesticide, in which the production of thiocholine from the hydrolysis of acetylthiocholine (ATCh) catalyzed by AChE is reduced. Thiocholine 140-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 29567179-4 2018 The detection mechanism monitors the inhibition of the activity of acetylcholinesterase (AChE) by the pesticide, in which the production of thiocholine from the hydrolysis of acetylthiocholine (ATCh) catalyzed by AChE is reduced. Thiocholine 140-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-217 29567179-4 2018 The detection mechanism monitors the inhibition of the activity of acetylcholinesterase (AChE) by the pesticide, in which the production of thiocholine from the hydrolysis of acetylthiocholine (ATCh) catalyzed by AChE is reduced. Acetylthiocholine 175-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 29567179-4 2018 The detection mechanism monitors the inhibition of the activity of acetylcholinesterase (AChE) by the pesticide, in which the production of thiocholine from the hydrolysis of acetylthiocholine (ATCh) catalyzed by AChE is reduced. Acetylthiocholine 175-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 29567179-4 2018 The detection mechanism monitors the inhibition of the activity of acetylcholinesterase (AChE) by the pesticide, in which the production of thiocholine from the hydrolysis of acetylthiocholine (ATCh) catalyzed by AChE is reduced. Acetylthiocholine 175-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-217 29735900-0 2018 Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon. Paraoxon 162-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 29735900-1 2018 Nerve agents and oxon forms of organophosphorus pesticides act as strong irreversible inhibitors of two cholinesterases in the human body: acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BChE; EC 3.1.1.8), and are therefore highly toxic compounds. organophosphorus 31-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-159 29735900-1 2018 Nerve agents and oxon forms of organophosphorus pesticides act as strong irreversible inhibitors of two cholinesterases in the human body: acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BChE; EC 3.1.1.8), and are therefore highly toxic compounds. organophosphorus 31-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-165 29735900-2 2018 For the recovery of inhibited AChE, antidotes from the group of pyridinium or bispyridinium aldoxime reactivators (pralidoxime, obidoxime, HI-6) are used in combination with anticholinergics and anticonvulsives. pyridine 64-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 29735900-2 2018 For the recovery of inhibited AChE, antidotes from the group of pyridinium or bispyridinium aldoxime reactivators (pralidoxime, obidoxime, HI-6) are used in combination with anticholinergics and anticonvulsives. bispyridinium aldoxime 78-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 29735900-2 2018 For the recovery of inhibited AChE, antidotes from the group of pyridinium or bispyridinium aldoxime reactivators (pralidoxime, obidoxime, HI-6) are used in combination with anticholinergics and anticonvulsives. Obidoxime Chloride 128-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 29735900-2 2018 For the recovery of inhibited AChE, antidotes from the group of pyridinium or bispyridinium aldoxime reactivators (pralidoxime, obidoxime, HI-6) are used in combination with anticholinergics and anticonvulsives. asoxime chloride 139-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 29735900-4 2018 Three novel oximes (K131, K142, K153) with an oxime group in position four of the pyridinium ring were designed and then tested for their potency to reactivate human (Homo sapiens sapiens) AChE (HssACHE) and BChE (HssBChE) inhibited by the pesticide paraoxon (diethyl 4-nitrophenyl phosphate). Oximes 12-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-193 29735900-4 2018 Three novel oximes (K131, K142, K153) with an oxime group in position four of the pyridinium ring were designed and then tested for their potency to reactivate human (Homo sapiens sapiens) AChE (HssACHE) and BChE (HssBChE) inhibited by the pesticide paraoxon (diethyl 4-nitrophenyl phosphate). Oximes 12-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-193 29620852-5 2018 Furthermore, these MOF-derived materials were all successfully used as effective immobilization matrixes of acetylcholinesterase (AChE) to construct biosensors for the detection of methyl parathion. Methyl Parathion 181-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 29620852-5 2018 Furthermore, these MOF-derived materials were all successfully used as effective immobilization matrixes of acetylcholinesterase (AChE) to construct biosensors for the detection of methyl parathion. Methyl Parathion 181-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 29620852-6 2018 Especially, [La-MOF-NH2]N2 with wool-ball-like structure not only provided more active sites of multicontents to increase AChE immobilization amount but also facilitated the accessibility of electron transfer and shorten their diffusion length on the surface of electrode. [la-mof-nh2]n2 12-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 29652477-1 2018 The present work for the first time introduces nanosensors for luminescent monitoring of acetylcholinesterase (AChE)-catalyzed hydrolysis of endogenous acetylcholine (ACh) released in neuromuscular junctions of isolated muscles. Acetylcholine 89-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 29652477-1 2018 The present work for the first time introduces nanosensors for luminescent monitoring of acetylcholinesterase (AChE)-catalyzed hydrolysis of endogenous acetylcholine (ACh) released in neuromuscular junctions of isolated muscles. Acetylcholine 111-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 29652477-6 2018 The ability of the targeted SNs to sense an inhibiting effect of paraoxon on enzymatic activity of AChE in ex vivo conditions provides a way of mimicking external stimuli effects on enzymatic processes in the isolated muscles. Paraoxon 65-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 29429576-2 2018 Our strategy against AD involves design of multi-targeted 2-substituted-4,5-diphenyl-1H-imidazole analogues which can interact and inhibit AChE, thereby, increasing the synaptic availability of ACh, inhibit BuChE, relieve induced oxidative stress and confer a neuroprotective role. 2-substituted-4,5-diphenyl-1h-imidazole 58-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 29463072-0 2018 The Effects of Donepezil, an Acetylcholinesterase Inhibitor, on Impaired Learning and Memory in Rodents. Donepezil 15-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 29635895-0 2018 Flavonoids as acetylcholinesterase inhibitors: Current therapeutic standing and future prospects. Flavonoids 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 29635895-8 2018 This review deals with various plant-derived flavonoids, their preclinical potential as AChE inhibitors, in established assays, possible mechanisms of action, and structural activity relationship (SAR). Flavonoids 45-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 29463072-1 2018 A previous study in humans demonstrated the sustained inhibitory effects of donepezil on acetylcholinesterase (AChE) activity; however, the effective concentration of donepezil in humans and animals is unclear. Donepezil 76-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 29463072-1 2018 A previous study in humans demonstrated the sustained inhibitory effects of donepezil on acetylcholinesterase (AChE) activity; however, the effective concentration of donepezil in humans and animals is unclear. Donepezil 76-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 29463072-2 2018 This study aimed to characterize the effective concentration of donepezil on AChE inhibition and impaired learning and memory in rodents. Donepezil 64-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 29463072-5 2018 Plasma AChE activity was negatively correlated with plasma donepezil concentration. Donepezil 59-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 7-11 29463072-9 2018 In conclusion, our findings suggest that the AChE inhibitory activity and pharmacological effects of donepezil can be predicted by the concentration of donepezil. Donepezil 152-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 28446076-0 2018 Behavior of uncharged oximes compared to HI6 and 2-PAM in the human AChE-tabun conjugate: a molecular modeling approach. Oximes 22-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 28446076-0 2018 Behavior of uncharged oximes compared to HI6 and 2-PAM in the human AChE-tabun conjugate: a molecular modeling approach. asoxime chloride 41-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 28446076-1 2018 Tabun is one of the most dangerous nerve agents because it has deleterious effects like inhibition of the essential enzymes acetylcholinesterase (AChE) and butyrylcholinesterase. tabun 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 28446076-1 2018 Tabun is one of the most dangerous nerve agents because it has deleterious effects like inhibition of the essential enzymes acetylcholinesterase (AChE) and butyrylcholinesterase. tabun 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 28446076-2 2018 Some oximes such HI6 as 2-PAM are nucleophiles that are capable to reactivate inhibited human AChE under some conditions. Oximes 5-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 28446076-2 2018 Some oximes such HI6 as 2-PAM are nucleophiles that are capable to reactivate inhibited human AChE under some conditions. asoxime chloride 17-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 28446076-7 2018 In contrast, HI 6 and 2-PAM showed high binding energy values with great contribution of the amino acid Asp74, demonstrating the importance of the quaternary nitrogen to the affinity and interaction of the oximes/AChE tabun-inhibited complexes. asoxime chloride 13-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-217 28446076-7 2018 In contrast, HI 6 and 2-PAM showed high binding energy values with great contribution of the amino acid Asp74, demonstrating the importance of the quaternary nitrogen to the affinity and interaction of the oximes/AChE tabun-inhibited complexes. Nitrogen 158-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-217 28463066-7 2018 Parathion dominated for acetylcholinesterase (ACH) with -4.57 kcal/mol (448.09 muM) and lastly dichlorodiphenyltrichloroethane for glutathione S-transferase (GST), -5.43 kcal/mol (103.88 muM). Parathion 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 28463066-7 2018 Parathion dominated for acetylcholinesterase (ACH) with -4.57 kcal/mol (448.09 muM) and lastly dichlorodiphenyltrichloroethane for glutathione S-transferase (GST), -5.43 kcal/mol (103.88 muM). Parathion 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-49 29582230-2 2018 Binding free energy calculations and the analysis of the geometrical parameters highlight the importance of the stereochemistry of huprines in AChE inhibition. huprines 131-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 29299992-1 2018 BACKGROUND: Donepezil (DPZ) is widely prescribed as a specific and reversible acetylcholinesterase inhibitor for the symptomatic treatment of mild to moderate Alzheimer"s disease (AD). Donepezil 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 29299992-1 2018 BACKGROUND: Donepezil (DPZ) is widely prescribed as a specific and reversible acetylcholinesterase inhibitor for the symptomatic treatment of mild to moderate Alzheimer"s disease (AD). Donepezil 23-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 29336270-12 2018 RESULTS AND CONCLUSION: With no predicted indication of adverse effects on humans, this study unravels four active multi-target inhibitors against AChE with promising affinities and good ADMET profile for the potential use in AD treatment. admet 187-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 29533874-1 2018 Novel tacrine-benzyl quinolone carboxylic acid (tacrine-BQCA) hybrids were designed based on multi-target directed ligands (MTLDs) paradigm, synthesized and evaluated in vitro as inhibitors of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE). Tacrine 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 221-226 29533874-1 2018 Novel tacrine-benzyl quinolone carboxylic acid (tacrine-BQCA) hybrids were designed based on multi-target directed ligands (MTLDs) paradigm, synthesized and evaluated in vitro as inhibitors of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE). Tacrine 48-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 221-226 29533874-4 2018 All the novel tacrine-BQCA hybrids were able to block the action of hAChE and hBChE in micromolar to nanomolar range. Tacrine 14-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-73 29670172-2 2018 These effects were observed upon experimental blockage of the ACh-degrading enzyme (ACH esterase; ACHE), by Huperzine A. Acetylcholine 62-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 29635895-9 2018 RESULTS AND CONCLUSIONS: Subsequently, a number of plant-derived flavonoids with outstanding efficacy and potency as AChE inhibitors, the mechanistic, their safety profiles, and pharmacokinetic attributes have been discussed. Flavonoids 65-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 29553731-0 2018 Dynamic Mechanism of a Fluorinated Oxime Reactivator Unbinding from AChE Gorge in Polarizable Water. Oximes 35-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 29553731-0 2018 Dynamic Mechanism of a Fluorinated Oxime Reactivator Unbinding from AChE Gorge in Polarizable Water. Water 94-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 29850593-0 2018 Inhibition of Acetylcholinesterase and Butyrylcholinesterase by a Plant Secondary Metabolite Boldine. boldine 93-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 29850593-2 2018 Boldine is a natural alkaloid and it was mentioned in some older works that it can inhibit some kinds of AChE. boldine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 29527733-1 2018 A series of N-substituted-5-chloro-2(3H)-benzoxazolone derivatives were synthesized and evaluated for their acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) inhibitory, and antioxidant activities. n-substituted-5-chloro-2(3h)-benzoxazolone 12-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 29527733-5 2018 The biological activity results revealed that all of the title compounds displayed higher AChE inhibitory activity than the reference compound, rivastigmine, and were selective for AChE. Rivastigmine 144-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 29527733-7 2018 The molecular docking study of compound 7 showed that this compound can interact with the catalytic active site (CAS) of AChE and also has potential metal chelating ability and a proper log P value. Metals 149-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 29427857-1 2018 A series of thirty-three alkynyl and beta-ketophosphonates were evaluated for their in vitro acetyl- and butyryl-cholinesterase (AChE and BChE) inhibitory activities using Ellman"s spectrophotometric method. alkynyl and beta-ketophosphonates 25-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 28417668-2 2018 Acetylcholine (ACh) acts through the regulation of AChE activity, which can play a key role in accelerating senile amyloid beta-peptide (Abeta) plaque deposition. Acetylcholine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 28417668-2 2018 Acetylcholine (ACh) acts through the regulation of AChE activity, which can play a key role in accelerating senile amyloid beta-peptide (Abeta) plaque deposition. Acetylcholine 15-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 29067789-1 2018 The objective of this study was to elucidate the pharmacokinetics and metabolite formation of newly developed non-selective AChE/BChE 7-MEOTA-donepezil-like inhibitors for potential therapeutic use in Alzheimer"s disease (AD) patients. 7-methoxytacrine 134-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 29067789-1 2018 The objective of this study was to elucidate the pharmacokinetics and metabolite formation of newly developed non-selective AChE/BChE 7-MEOTA-donepezil-like inhibitors for potential therapeutic use in Alzheimer"s disease (AD) patients. Donepezil 142-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 28334147-8 2018 Conceivably, low levels of AChE activity could enhance the impact of acetylcholine on pyramidal neurons to counterbalance other involutional factors that mediate the decline of memory capacity during average aging. Acetylcholine 69-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 29456161-7 2018 We used the PET tracer N-11C-methyl-piperidin-4-yl propionate to scan for acetylcholinesterase activity. n-11c-methyl-piperidin-4-yl propionate 23-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 29620652-7 2018 LESSONS: Our case suggests that neostigmine, an acetylcholinesterase inhibitor, may warrant further investigation in patients with thyroid storm-induced severe sinus tachycardia. Neostigmine 32-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 29395675-11 2018 Ephedrine/salbutamol were very effective in AChE and DOK7 deficiencies and were useful as adjuncts in other types of CMS. Ephedrine 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 29395675-11 2018 Ephedrine/salbutamol were very effective in AChE and DOK7 deficiencies and were useful as adjuncts in other types of CMS. Albuterol 10-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 29597336-5 2018 Coumestrol showed pronounced AChE and BChE activity with IC50 values of 42.33 and 24.64 microM, respectively, acting as a dual cholinesterase (ChE) inhibitor. Coumestrol 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 29597336-7 2018 Kinetic studies of coumestrol showed AChE and BChE inhibition in a competitive and mixed fashion, whereas puerarol showed mixed inhibition for BACE1. Coumestrol 19-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 29632858-7 2018 Compounds from coumarinyl thiazole series with potent AChE activity (6b, 6h, 6i, and 6k) were found to interact with AChE in the active site with MOE score of -10.19, -9.97, -9.68, and -11.03 Kcal.mol-1, respectively. Thiazoles 26-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 29632858-7 2018 Compounds from coumarinyl thiazole series with potent AChE activity (6b, 6h, 6i, and 6k) were found to interact with AChE in the active site with MOE score of -10.19, -9.97, -9.68, and -11.03 Kcal.mol-1, respectively. Thiazoles 26-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 29566057-8 2018 In patients with fecal incontinence responding to SMDCs treatment, the improvement of clinical symptoms was positively linked with the AChE activity of the SMDCs injected. smdcs 50-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 29451128-2 2018 The biosensor was fabricated with poly(ethylene glycol) (PEG) hydrogel microarrays that entrapped acetylcholinesterase (AChE) and quantum dots (QDs) as fluorescence reporters. Polyethylene Glycols 34-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-118 29451128-2 2018 The biosensor was fabricated with poly(ethylene glycol) (PEG) hydrogel microarrays that entrapped acetylcholinesterase (AChE) and quantum dots (QDs) as fluorescence reporters. Polyethylene Glycols 57-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-118 29451128-2 2018 The biosensor was fabricated with poly(ethylene glycol) (PEG) hydrogel microarrays that entrapped acetylcholinesterase (AChE) and quantum dots (QDs) as fluorescence reporters. Polyethylene Glycols 57-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 29451128-5 2018 PEG hydrogel microarray entrapping QD-decorated Ag@Silica and AChE was prepared via photopatterning process. Polyethylene Glycols 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 29451128-6 2018 The entrapped AChE hydrolyzed paraoxon to produce p-nitrophenol within the hydrogel microstructure, which subsequently quenched the fluorescence of the QDs on the surface of Ag@Silica. Paraoxon 30-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 29451128-6 2018 The entrapped AChE hydrolyzed paraoxon to produce p-nitrophenol within the hydrogel microstructure, which subsequently quenched the fluorescence of the QDs on the surface of Ag@Silica. 4-nitrophenol 50-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 29451128-6 2018 The entrapped AChE hydrolyzed paraoxon to produce p-nitrophenol within the hydrogel microstructure, which subsequently quenched the fluorescence of the QDs on the surface of Ag@Silica. Silicon Dioxide 177-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 29593539-1 2018 Organophosphorus agents (OPs) are irreversible inhibitors of acetylcholinesterase (AChE). organophosphorus agents 0-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 29593539-1 2018 Organophosphorus agents (OPs) are irreversible inhibitors of acetylcholinesterase (AChE). organophosphorus agents 0-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 29593539-1 2018 Organophosphorus agents (OPs) are irreversible inhibitors of acetylcholinesterase (AChE). OPS 25-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 29593539-1 2018 Organophosphorus agents (OPs) are irreversible inhibitors of acetylcholinesterase (AChE). OPS 25-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 29706984-2 2018 While acetylcholinesterase (AChE) inhibitors are known to cause appetite loss, we sometimes encounter patients in whom switching from donepezil (AChE inhibitor) to rivastigmine (AChE and butyrylcholinesterase [BuChE] inhibitor) improves appetite. Donepezil 134-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 29706984-2 2018 While acetylcholinesterase (AChE) inhibitors are known to cause appetite loss, we sometimes encounter patients in whom switching from donepezil (AChE inhibitor) to rivastigmine (AChE and butyrylcholinesterase [BuChE] inhibitor) improves appetite. Donepezil 134-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 29535344-4 2018 A series of hydroxylated 2-phenylbenzofurans compounds were designed, synthesized and their inhibitory activities toward acetylcholinesterase (AChE) and BChE enzymes were evaluated. 2-phenylbenzofurans 25-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 29535344-4 2018 A series of hydroxylated 2-phenylbenzofurans compounds were designed, synthesized and their inhibitory activities toward acetylcholinesterase (AChE) and BChE enzymes were evaluated. 2-phenylbenzofurans 25-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 29534488-4 2018 Both quaternization upon methylation of the quinoline nitrogen atom, and tethering of a triazole ring, with, in some cases, the additional incorporation of a polyphenol-like moiety, result in more polar compounds with higher inhibitory activity against human AChE (up to 190-fold) and butyrylcholinesterase (up to 40-fold) than pyridostigmine, the standard drug for symptomatic treatment of myasthenia gravis. Nitrogen 54-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 259-263 29421570-2 2018 The molecular hybridization approach was based on the combination, in a single molecule, of the pharmacophoric N-benzyl-piperidine subunit of donepezil, the substituted hydroxy-piperidine fragment of the AChE inhibitor LASSBio-767, and an acylhydrazone linker, a privileged structure present in a number of synthetic aryl- and aryl-acylhydrazone derivatives with significant AChE and anti-inflammatory activities. 1-benzylpiperidine 111-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-208 29421570-2 2018 The molecular hybridization approach was based on the combination, in a single molecule, of the pharmacophoric N-benzyl-piperidine subunit of donepezil, the substituted hydroxy-piperidine fragment of the AChE inhibitor LASSBio-767, and an acylhydrazone linker, a privileged structure present in a number of synthetic aryl- and aryl-acylhydrazone derivatives with significant AChE and anti-inflammatory activities. 1-benzylpiperidine 111-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 375-379 29421570-2 2018 The molecular hybridization approach was based on the combination, in a single molecule, of the pharmacophoric N-benzyl-piperidine subunit of donepezil, the substituted hydroxy-piperidine fragment of the AChE inhibitor LASSBio-767, and an acylhydrazone linker, a privileged structure present in a number of synthetic aryl- and aryl-acylhydrazone derivatives with significant AChE and anti-inflammatory activities. Donepezil 142-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 375-379 29421570-2 2018 The molecular hybridization approach was based on the combination, in a single molecule, of the pharmacophoric N-benzyl-piperidine subunit of donepezil, the substituted hydroxy-piperidine fragment of the AChE inhibitor LASSBio-767, and an acylhydrazone linker, a privileged structure present in a number of synthetic aryl- and aryl-acylhydrazone derivatives with significant AChE and anti-inflammatory activities. hydroxy-piperidine 169-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-208 29421570-2 2018 The molecular hybridization approach was based on the combination, in a single molecule, of the pharmacophoric N-benzyl-piperidine subunit of donepezil, the substituted hydroxy-piperidine fragment of the AChE inhibitor LASSBio-767, and an acylhydrazone linker, a privileged structure present in a number of synthetic aryl- and aryl-acylhydrazone derivatives with significant AChE and anti-inflammatory activities. 3-O-acetylspectaline 219-230 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-208 29421570-2 2018 The molecular hybridization approach was based on the combination, in a single molecule, of the pharmacophoric N-benzyl-piperidine subunit of donepezil, the substituted hydroxy-piperidine fragment of the AChE inhibitor LASSBio-767, and an acylhydrazone linker, a privileged structure present in a number of synthetic aryl- and aryl-acylhydrazone derivatives with significant AChE and anti-inflammatory activities. acylhydrazone 239-252 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-208 29421570-2 2018 The molecular hybridization approach was based on the combination, in a single molecule, of the pharmacophoric N-benzyl-piperidine subunit of donepezil, the substituted hydroxy-piperidine fragment of the AChE inhibitor LASSBio-767, and an acylhydrazone linker, a privileged structure present in a number of synthetic aryl- and aryl-acylhydrazone derivatives with significant AChE and anti-inflammatory activities. aryl- 317-322 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-208 29421570-2 2018 The molecular hybridization approach was based on the combination, in a single molecule, of the pharmacophoric N-benzyl-piperidine subunit of donepezil, the substituted hydroxy-piperidine fragment of the AChE inhibitor LASSBio-767, and an acylhydrazone linker, a privileged structure present in a number of synthetic aryl- and aryl-acylhydrazone derivatives with significant AChE and anti-inflammatory activities. aryl-acylhydrazone 327-345 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-208 29421570-5 2018 In addition, compound 4c showed a similar binding mode to donepezil in both acetylated and free forms of AChE enzyme in molecular docking studies and did not show relevant toxic effects on in vitro and in vivo assays, with good predicted ADME parameters in silico. Donepezil 58-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 29438888-2 2018 A series of tricyclic pyrazolo[1,5-d][1,4]benzoxazepin-5(6H)-one derivatives were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. tricyclic pyrazolo[1,5-d][1,4]benzoxazepin-5(6h)-one 12-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 29438888-2 2018 A series of tricyclic pyrazolo[1,5-d][1,4]benzoxazepin-5(6H)-one derivatives were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. tricyclic pyrazolo[1,5-d][1,4]benzoxazepin-5(6h)-one 12-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 29563775-1 2018 Background: Intoxication by nerve agents could be prevented by using small acetylcholinesterase inhibitors (eg, pyridostigmine) for potentially exposed personnel. Pyridostigmine Bromide 112-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 29441784-4 2018 Interestingly, by combining the quenching and recognition ability of silver nanoparticles (AgNPs) with the optical capacity of CDs, a label-free strategy for specifically monitoring H2O2-generated biocatalytic processes was proposed, such as glucose oxidase-induced conversion of glucose, cholesterol oxidase-catalyzed oxidization of cholesterol, and bienzyme of acetylcholinesterase and choline oxidase-mediated reaction of acetylcholine. Silver 69-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 363-383 29441784-4 2018 Interestingly, by combining the quenching and recognition ability of silver nanoparticles (AgNPs) with the optical capacity of CDs, a label-free strategy for specifically monitoring H2O2-generated biocatalytic processes was proposed, such as glucose oxidase-induced conversion of glucose, cholesterol oxidase-catalyzed oxidization of cholesterol, and bienzyme of acetylcholinesterase and choline oxidase-mediated reaction of acetylcholine. cds 127-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 363-383 29441784-4 2018 Interestingly, by combining the quenching and recognition ability of silver nanoparticles (AgNPs) with the optical capacity of CDs, a label-free strategy for specifically monitoring H2O2-generated biocatalytic processes was proposed, such as glucose oxidase-induced conversion of glucose, cholesterol oxidase-catalyzed oxidization of cholesterol, and bienzyme of acetylcholinesterase and choline oxidase-mediated reaction of acetylcholine. Hydrogen Peroxide 182-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 363-383 29441784-4 2018 Interestingly, by combining the quenching and recognition ability of silver nanoparticles (AgNPs) with the optical capacity of CDs, a label-free strategy for specifically monitoring H2O2-generated biocatalytic processes was proposed, such as glucose oxidase-induced conversion of glucose, cholesterol oxidase-catalyzed oxidization of cholesterol, and bienzyme of acetylcholinesterase and choline oxidase-mediated reaction of acetylcholine. Glucose 242-249 acetylcholinesterase (Cartwright blood group) Homo sapiens 363-383 29441784-4 2018 Interestingly, by combining the quenching and recognition ability of silver nanoparticles (AgNPs) with the optical capacity of CDs, a label-free strategy for specifically monitoring H2O2-generated biocatalytic processes was proposed, such as glucose oxidase-induced conversion of glucose, cholesterol oxidase-catalyzed oxidization of cholesterol, and bienzyme of acetylcholinesterase and choline oxidase-mediated reaction of acetylcholine. Cholesterol 289-300 acetylcholinesterase (Cartwright blood group) Homo sapiens 363-383 29559907-5 2018 We report results from a single-case study in which DFMO was administered, for the first time, in an attempt to slow progression of AD in a single woman with multi-domain, amnestic MCI who was unable to tolerate an acetylcholinesterase inhibitor. Eflornithine 52-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 215-235 29431448-0 2018 Hupercumines A and B, Lycopodium Alkaloids from Huperzia cunninghamioides, Inhibiting Acetylcholinesterase. hupercumines a and b 0-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 29431448-3 2018 Hupercumines A (1) and B (2) showed moderate inhibitory activity against acetylcholinesterase. hupercumines a 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 29431448-3 2018 Hupercumines A (1) and B (2) showed moderate inhibitory activity against acetylcholinesterase. and b 19-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 29670172-2 2018 These effects were observed upon experimental blockage of the ACh-degrading enzyme (ACH esterase; ACHE), by Huperzine A. huperzine A 108-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 29670172-5 2018 Blocking the breakdown of ACh by inhibiting ACHE, or interfering with necroptosis, did not improve the overall follicle survival, but promoted the growth of macaque follicles from the secondary to the small antral stage in vitro, which was correlated with oocyte development. Acetylcholine 26-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 28974110-3 2018 Three acetylcholinesterase inhibitors (ACHEIs) have been approved for AD: donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne). Galantamine 135-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-26 28974110-3 2018 Three acetylcholinesterase inhibitors (ACHEIs) have been approved for AD: donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne). Donepezil 74-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-26 28974110-3 2018 Three acetylcholinesterase inhibitors (ACHEIs) have been approved for AD: donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne). Donepezil 85-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-26 29577198-1 2018 The efficiency of different reactivators of cholinesterase (toxogonin, dipiroxime, pralidoxime, carboxim, HI-6, and methoxime) at inhibition of butyrylcholinesterase and human acetylcholinesterase by organophosphate insecticide malathion was evaluated in in vitro experiments. pralidoxime 83-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-196 29577198-3 2018 Oxime-induced reactivation of acetylcholinesterase was most pronounced in dipyroxime and toxogonin: parameters of the kinetics of reduction of the phosphorylated enzyme differed by more than 2 times from the values received with the use of other reactivators. Oximes 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 29577198-3 2018 Oxime-induced reactivation of acetylcholinesterase was most pronounced in dipyroxime and toxogonin: parameters of the kinetics of reduction of the phosphorylated enzyme differed by more than 2 times from the values received with the use of other reactivators. Trimedoxime 74-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 26111751-2 2018 Inhibition of acetylcholinesterase (AChE) in erythrocyte and butyrylcholinesterase (BChE) in plasma is the predominant toxic effect of organophosphate and carbamate pesticides. Organophosphates 135-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 26111751-2 2018 Inhibition of acetylcholinesterase (AChE) in erythrocyte and butyrylcholinesterase (BChE) in plasma is the predominant toxic effect of organophosphate and carbamate pesticides. Organophosphates 135-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 26111751-2 2018 Inhibition of acetylcholinesterase (AChE) in erythrocyte and butyrylcholinesterase (BChE) in plasma is the predominant toxic effect of organophosphate and carbamate pesticides. Carbamates 155-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 26111751-2 2018 Inhibition of acetylcholinesterase (AChE) in erythrocyte and butyrylcholinesterase (BChE) in plasma is the predominant toxic effect of organophosphate and carbamate pesticides. Carbamates 155-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 28852920-5 2018 Inhibition of both the catalytic activities of AChE with edrophonium significantly reduced the amount of mineralization by decreasing the alkaline phosphatase (ALP) activity and expression of differentiation-related genes such as RUNX-2, COL1A, ALP, OC, and OP significantly (p < 0.05). Edrophonium 57-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 29044771-10 2018 Galanthamine, galanthamine N-oxide and powelline should be the most prominent inhibitors of substrate accommodation in the active site of the Torpedo californica AChE (TcAChE), hAChE and hBChE enzymes. Galantamine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-166 29044771-10 2018 Galanthamine, galanthamine N-oxide and powelline should be the most prominent inhibitors of substrate accommodation in the active site of the Torpedo californica AChE (TcAChE), hAChE and hBChE enzymes. Galanthamine N-Oxide 14-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-166 29044771-10 2018 Galanthamine, galanthamine N-oxide and powelline should be the most prominent inhibitors of substrate accommodation in the active site of the Torpedo californica AChE (TcAChE), hAChE and hBChE enzymes. Galanthamine N-Oxide 14-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-182 29044771-10 2018 Galanthamine, galanthamine N-oxide and powelline should be the most prominent inhibitors of substrate accommodation in the active site of the Torpedo californica AChE (TcAChE), hAChE and hBChE enzymes. powelline 39-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-166 29044771-10 2018 Galanthamine, galanthamine N-oxide and powelline should be the most prominent inhibitors of substrate accommodation in the active site of the Torpedo californica AChE (TcAChE), hAChE and hBChE enzymes. powelline 39-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-182 29570959-3 2018 Galantamine not only is an acetylcholinesterase inhibitor but has a dual mode of action as a alpha-7nACh receptor modulator as well. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 29390885-3 2018 The aim of the current study was to design multi-targeted directed lead structures based on the coumarin scaffold with inhibitory properties at two key enzymes in disease relevant systems, i.e. acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B). coumarin 96-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 194-214 29390885-3 2018 The aim of the current study was to design multi-targeted directed lead structures based on the coumarin scaffold with inhibitory properties at two key enzymes in disease relevant systems, i.e. acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B). coumarin 96-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 216-220 29390887-1 2018 Numerous studies show that tacrine derivatives exhibit increased inhibitory activity against butyrylcholinesterase (BuChE) and acetylcholinesterase (AChE). Tacrine 27-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 29310276-3 2018 Apyrase and acetylcholinesterase (AChE), as selective elements, are used to recognize adenosine 5"-triphosphate (ATP) and acetylcholine (ACh), respectively. Adenosine Triphosphate 86-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 29310276-3 2018 Apyrase and acetylcholinesterase (AChE), as selective elements, are used to recognize adenosine 5"-triphosphate (ATP) and acetylcholine (ACh), respectively. Adenosine Triphosphate 86-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 29310276-3 2018 Apyrase and acetylcholinesterase (AChE), as selective elements, are used to recognize adenosine 5"-triphosphate (ATP) and acetylcholine (ACh), respectively. Adenosine Triphosphate 113-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 29310276-3 2018 Apyrase and acetylcholinesterase (AChE), as selective elements, are used to recognize adenosine 5"-triphosphate (ATP) and acetylcholine (ACh), respectively. Adenosine Triphosphate 113-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 29310276-3 2018 Apyrase and acetylcholinesterase (AChE), as selective elements, are used to recognize adenosine 5"-triphosphate (ATP) and acetylcholine (ACh), respectively. Acetylcholine 12-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 29310276-3 2018 Apyrase and acetylcholinesterase (AChE), as selective elements, are used to recognize adenosine 5"-triphosphate (ATP) and acetylcholine (ACh), respectively. Acetylcholine 34-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 29535625-1 2018 Butyrylcholinesterase (BChE), a plasma enzyme that hydrolyses the neurotransmitter, acetylcholine relatively well, with far lower efficiency than acetylcholinesterase (AChE) but with the capability to degrade a broad range of bioactive esters. Esters 236-242 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-166 29535625-1 2018 Butyrylcholinesterase (BChE), a plasma enzyme that hydrolyses the neurotransmitter, acetylcholine relatively well, with far lower efficiency than acetylcholinesterase (AChE) but with the capability to degrade a broad range of bioactive esters. Esters 236-242 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-172 29291803-7 2018 Since the latter is the enzymatic hydrolysis product of acetylcholinesterase (AChE) and the activity of AChE can be inhibited by OPs, the T(TA)2-TiO2/FTO was further used for PEC assay of OPs. OPS 129-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 29291803-7 2018 Since the latter is the enzymatic hydrolysis product of acetylcholinesterase (AChE) and the activity of AChE can be inhibited by OPs, the T(TA)2-TiO2/FTO was further used for PEC assay of OPs. OPS 129-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 29291803-7 2018 Since the latter is the enzymatic hydrolysis product of acetylcholinesterase (AChE) and the activity of AChE can be inhibited by OPs, the T(TA)2-TiO2/FTO was further used for PEC assay of OPs. OPS 129-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 29291803-7 2018 Since the latter is the enzymatic hydrolysis product of acetylcholinesterase (AChE) and the activity of AChE can be inhibited by OPs, the T(TA)2-TiO2/FTO was further used for PEC assay of OPs. t(ta)2-tio2 138-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 29291803-7 2018 Since the latter is the enzymatic hydrolysis product of acetylcholinesterase (AChE) and the activity of AChE can be inhibited by OPs, the T(TA)2-TiO2/FTO was further used for PEC assay of OPs. t(ta)2-tio2 138-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 29291803-7 2018 Since the latter is the enzymatic hydrolysis product of acetylcholinesterase (AChE) and the activity of AChE can be inhibited by OPs, the T(TA)2-TiO2/FTO was further used for PEC assay of OPs. t(ta)2-tio2 138-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 29467029-0 2018 A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase. oxime k203 18-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 28942211-0 2018 Functionalized polyacrylamide as an acetylcholinesterase-inspired biomimetic device for electrochemical sensing of organophosphorus pesticides. polyacrylamide 15-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 28942211-0 2018 Functionalized polyacrylamide as an acetylcholinesterase-inspired biomimetic device for electrochemical sensing of organophosphorus pesticides. organophosphorus 115-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 28942211-4 2018 Herein, for the first time, we propose a biomimetic biosensor for organophosphorus pesticide detection employing a functionalized polyacrylamide, polyhydroxamicalkanoate (PHA), which mimics the performance of the acetylcholinesterase (AChE) enzyme. organophosphorus 66-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-233 28942211-4 2018 Herein, for the first time, we propose a biomimetic biosensor for organophosphorus pesticide detection employing a functionalized polyacrylamide, polyhydroxamicalkanoate (PHA), which mimics the performance of the acetylcholinesterase (AChE) enzyme. organophosphorus 66-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 235-239 28942211-4 2018 Herein, for the first time, we propose a biomimetic biosensor for organophosphorus pesticide detection employing a functionalized polyacrylamide, polyhydroxamicalkanoate (PHA), which mimics the performance of the acetylcholinesterase (AChE) enzyme. polyacrylamide 130-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-233 28942211-4 2018 Herein, for the first time, we propose a biomimetic biosensor for organophosphorus pesticide detection employing a functionalized polyacrylamide, polyhydroxamicalkanoate (PHA), which mimics the performance of the acetylcholinesterase (AChE) enzyme. polyacrylamide 130-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 235-239 28942211-4 2018 Herein, for the first time, we propose a biomimetic biosensor for organophosphorus pesticide detection employing a functionalized polyacrylamide, polyhydroxamicalkanoate (PHA), which mimics the performance of the acetylcholinesterase (AChE) enzyme. polyhydroxamicalkanoate 146-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-233 28942211-4 2018 Herein, for the first time, we propose a biomimetic biosensor for organophosphorus pesticide detection employing a functionalized polyacrylamide, polyhydroxamicalkanoate (PHA), which mimics the performance of the acetylcholinesterase (AChE) enzyme. polyhydroxamicalkanoate 146-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 235-239 29430663-2 2018 The aim of the study was to investigate the association between the 5"-hydroxymethylcytosine (5hmC) rate in the promoters of acetylcholinesterase (AChE) and homeobox C4 (HoxC4) genes and human sperm concentration/motility. 5-hydroxymethylcytosine 68-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 29430663-2 2018 The aim of the study was to investigate the association between the 5"-hydroxymethylcytosine (5hmC) rate in the promoters of acetylcholinesterase (AChE) and homeobox C4 (HoxC4) genes and human sperm concentration/motility. 5-hydroxymethylcytosine 68-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 29430663-2 2018 The aim of the study was to investigate the association between the 5"-hydroxymethylcytosine (5hmC) rate in the promoters of acetylcholinesterase (AChE) and homeobox C4 (HoxC4) genes and human sperm concentration/motility. 5-hydroxymethylcytosine 94-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 29430663-2 2018 The aim of the study was to investigate the association between the 5"-hydroxymethylcytosine (5hmC) rate in the promoters of acetylcholinesterase (AChE) and homeobox C4 (HoxC4) genes and human sperm concentration/motility. 5-hydroxymethylcytosine 94-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 29430663-5 2018 The 5hmC rate in the AChE promoter in group AZ and OAZ was higher than that in group NZ (p < .05). 5-hydroxymethylcytosine 4-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 29430663-5 2018 The 5hmC rate in the AChE promoter in group AZ and OAZ was higher than that in group NZ (p < .05). OAZ 51-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 29430663-8 2018 These results indicated that altered 5hmC rates of AChE and HoxC4 promoters are associated with low sperm motility and sperm concentration respectively. 5-hydroxymethylcytosine 37-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 29324339-0 2018 Novel donepezil-like N-benzylpyridinium salt derivatives as AChE inhibitors and their corresponding dihydropyridine "bio-oxidizable" prodrugs: Synthesis, biological evaluation and structure-activity relationship. Donepezil 6-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 28617100-0 2018 Discovery of potent and selective acetylcholinesterase (AChE) inhibitors: acacetin 7-O-methyl ether Mannich base derivatives synthesised from easy access natural product naringin. acacetin 7-o-methyl ether mannich base 74-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 28617100-0 2018 Discovery of potent and selective acetylcholinesterase (AChE) inhibitors: acacetin 7-O-methyl ether Mannich base derivatives synthesised from easy access natural product naringin. acacetin 7-o-methyl ether mannich base 74-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 29414887-4 2018 A series of 15 drug-like various substituted derivatives of 2-(benzylamino-2-hydroxyalkyl)isoindoline-1,3-diones was designed by modification of cholinesterase inhibitors toward beta-secretase inhibition. 2-(benzylamino-2-hydroxyalkyl)isoindoline-1,3-diones 60-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-159 29405353-4 2018 This is ensured by acetylcholinesterase (AChE), which degrades ACh. Acetylcholine 41-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 28617100-4 2018 Among them, compound 7 (IC50 for AChE = 0.82 +- 0.08 mumol L-1, IC50 for BuChE = 46.30 +- 3.26 mumol L-1) showed a potent activity and high selectivity compared with the positive control Rivastigmine (IC50 for AChE = 10.54 +- 0.86 mumol L-1, IC50 for BuChE = 0.26 +- 0.08 mumol L-1). Rivastigmine 187-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 28617100-6 2018 Molecular docking study revealed that compound 7 could combine both catalytic active site (CAS) and peripheral active site (PAS) of AChE with four points (Trp84, Trp279, Tyr70 and Phe330), while it could bind with BuChE via only His 20. Aminosalicylic Acid 124-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 28617100-6 2018 Molecular docking study revealed that compound 7 could combine both catalytic active site (CAS) and peripheral active site (PAS) of AChE with four points (Trp84, Trp279, Tyr70 and Phe330), while it could bind with BuChE via only His 20. Histidine 229-232 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 28792233-0 2018 Synthesis of chalcone-imide derivatives and investigation of their anticancer and antimicrobial activities, carbonic anhydrase and acetylcholinesterase enzymes inhibition profiles. chalcone-imide 13-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-151 28792233-8 2018 Also, tacrine inhibited AChE showed a Ki value of 446.56 +- 58.33 nM. Tacrine 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 29323749-0 2018 Synthesis and biological evaluation of phloroglucinol derivatives possessing alpha-glycosidase, acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase inhibitory activity. Phloroglucinol 39-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 29323749-1 2018 A series of novel phloroglucinol derivatives were designed, synthesized, characterized spectroscopically and tested for their inhibitory activity against selected metabolic enzymes, including alpha-glycosidase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and human carbonic anhydrase I and II (hCA I and II). Phloroglucinol 18-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-231 29323749-1 2018 A series of novel phloroglucinol derivatives were designed, synthesized, characterized spectroscopically and tested for their inhibitory activity against selected metabolic enzymes, including alpha-glycosidase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and human carbonic anhydrase I and II (hCA I and II). Phloroglucinol 18-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-237 29195093-0 2018 Synthesis of derivatives of cleistopholine and their anti-acetylcholinesterase and anti-beta-amyloid aggregation activity. cleistopholine 28-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 29195093-1 2018 A series of 6- and 9-substituted cleistopholine derivatives has been designed, synthesized and investigated to inhibit the aggregation of acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and beta-myloid (A beta). 6- and 9-substituted cleistopholine 12-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 29195093-1 2018 A series of 6- and 9-substituted cleistopholine derivatives has been designed, synthesized and investigated to inhibit the aggregation of acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and beta-myloid (A beta). 6- and 9-substituted cleistopholine 12-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 29324339-0 2018 Novel donepezil-like N-benzylpyridinium salt derivatives as AChE inhibitors and their corresponding dihydropyridine "bio-oxidizable" prodrugs: Synthesis, biological evaluation and structure-activity relationship. n-benzylpyridinium salt 21-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 29479387-2 2018 Agents that inhibit acetylcholinesterase, such as neostigmine, may precipitate myotonia, and are therefore relatively contraindicated. Neostigmine 50-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 28822269-0 2018 Correlation of cholinergic drug induced quenching of acetylcholinesterase bound thioflavin-T fluorescence with their inhibition activity. thioflavin T 80-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 29111270-0 2018 4- Substituted sampangine derivatives: Novel acetylcholinesterase and beta-myloid aggregation inhibitors. 4- substituted sampangine 0-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 29111270-1 2018 A series of 4- substituted sampangine derivatives (4-aminoalkylaminosampangine Ar-NH(CH2)nNR1R2) has been designed, synthesized, and tested for their ability to inhibit acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and beta-myloid (Abeta) aggregation. 4- substituted sampangine 12-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-189 29111270-1 2018 A series of 4- substituted sampangine derivatives (4-aminoalkylaminosampangine Ar-NH(CH2)nNR1R2) has been designed, synthesized, and tested for their ability to inhibit acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and beta-myloid (Abeta) aggregation. 4- substituted sampangine 12-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 191-195 29111270-1 2018 A series of 4- substituted sampangine derivatives (4-aminoalkylaminosampangine Ar-NH(CH2)nNR1R2) has been designed, synthesized, and tested for their ability to inhibit acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and beta-myloid (Abeta) aggregation. 4-aminoalkylaminosampangine 51-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-189 29111270-1 2018 A series of 4- substituted sampangine derivatives (4-aminoalkylaminosampangine Ar-NH(CH2)nNR1R2) has been designed, synthesized, and tested for their ability to inhibit acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and beta-myloid (Abeta) aggregation. 4-aminoalkylaminosampangine 51-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 191-195 29283199-0 2018 Synthesis and investigation of the conversion reactions of pyrimidine-thiones with nucleophilic reagent and evaluation of their acetylcholinesterase, carbonic anhydrase inhibition, and antioxidant activities. pyrimidine-thiones 59-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 29283199-3 2018 These pyrimidine-thiones derivatives (A-K) showed good inhibitory action against acetylcholinesterase (AChE), and human carbonic anhydrase (hCA) isoforms I and II. pyrimidine-thiones 6-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 29283199-3 2018 These pyrimidine-thiones derivatives (A-K) showed good inhibitory action against acetylcholinesterase (AChE), and human carbonic anhydrase (hCA) isoforms I and II. pyrimidine-thiones 6-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 29251321-5 2018 Our results showed that the AchE inhibition rate of 10 micromol/l ZBH-ZM-06 was 12.5%, compared to 96.5% for carbonyl-oxycamptothecin (CPT-11). zbh-zm-06 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 29482737-2 2018 Like many other organophosphorus (OP) pesticides, the primary mechanism of the acute toxicity of phorate is acetylcholinesterase (AChE) inhibition mediated by its bioactivated oxon metabolite. Phorate 97-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 29482737-2 2018 Like many other organophosphorus (OP) pesticides, the primary mechanism of the acute toxicity of phorate is acetylcholinesterase (AChE) inhibition mediated by its bioactivated oxon metabolite. Phorate 97-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 29482737-2 2018 Like many other organophosphorus (OP) pesticides, the primary mechanism of the acute toxicity of phorate is acetylcholinesterase (AChE) inhibition mediated by its bioactivated oxon metabolite. oxon 176-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 29482737-2 2018 Like many other organophosphorus (OP) pesticides, the primary mechanism of the acute toxicity of phorate is acetylcholinesterase (AChE) inhibition mediated by its bioactivated oxon metabolite. oxon 176-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 29482737-10 2018 (2) 2-PAM Cl, showed limited effectiveness in reactivating PHO-inhibited AChE, suggesting that it may have limited usefulness in the clinical management of acute PHO intoxication. pralidoxime 4-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 29253600-0 2018 Cadmium induced ROS alters M1 and M3 receptors, leading to SN56 cholinergic neuronal loss, through AChE variants disruption. Cadmium 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 29253600-0 2018 Cadmium induced ROS alters M1 and M3 receptors, leading to SN56 cholinergic neuronal loss, through AChE variants disruption. ros 16-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 29253600-3 2018 This effect, partially mediated by M1 receptor blockade, triggering it through AChE splices variants alteration, may explain cadmium effects on learning and memory processes. Cadmium 125-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 29253600-5 2018 Moreover, it has been reported that antioxidant treatment could reverse cognitive disorders, muscarinic receptor and AChE variants alterations induced by cadmium. Cadmium 154-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 29253600-6 2018 Thus, we hypothesized that cadmium induced cell death of BF cholinergic neurons is mediated by oxidative stress generation and this mechanism could produce this effect, in part, through AChE variants altered by muscarinic receptors disruption. Cadmium 27-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 29253600-8 2018 Our results show that cadmium induces oxidative stress, which mediates partially the alteration of AChE variants and M2 to M4 muscarinic receptors expression and blockage of M1 receptor. Cadmium 22-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 29253600-9 2018 In addition, cadmium induced oxidative stress generation by M1 and M3 receptors alteration through AChE variants disruption, leading to cell death. Cadmium 13-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 29594716-0 2018 Controlled synthesis of polydopamine: A new strategy for highly sensitive fluorescence turn-on detection of acetylcholinesterase activity. polydopamine 24-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 29594716-3 2018 The enzyme acetylcholinesterase (AChE) is known catalyze the hydrolysis of acetylthiocholine to produce thiocholine. Acetylthiocholine 75-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 29594716-3 2018 The enzyme acetylcholinesterase (AChE) is known catalyze the hydrolysis of acetylthiocholine to produce thiocholine. Acetylthiocholine 75-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 29594716-3 2018 The enzyme acetylcholinesterase (AChE) is known catalyze the hydrolysis of acetylthiocholine to produce thiocholine. Thiocholine 81-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 29594716-3 2018 The enzyme acetylcholinesterase (AChE) is known catalyze the hydrolysis of acetylthiocholine to produce thiocholine. Thiocholine 81-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 29594716-9 2018 Graphical abstract Controlled synthesis of polydopamine for the highly sensitive and selective sensing of AChE activity is reported for the first time. polydopamine 43-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 29367595-1 2018 A series of 2-aryl-9-methyl-beta-carbolinium bromides (B) were synthesized and explored for anti-acetylcholinesterase (AChE) activities in vitro, action mechanism and structure-activity relationship. 2-aryl-9-methyl-beta-carbolinium bromides 12-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-117 29367595-1 2018 A series of 2-aryl-9-methyl-beta-carbolinium bromides (B) were synthesized and explored for anti-acetylcholinesterase (AChE) activities in vitro, action mechanism and structure-activity relationship. 2-aryl-9-methyl-beta-carbolinium bromides 12-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 29265146-0 2018 Enantioselective synthesis of novel pyrano[3,2-c]chromene derivatives as AChE inhibitors via an organocatalytic domino reaction. pyrano[3,2-c]chromene 36-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 29258018-3 2018 Flavonoids with AChE inhibitory activities and low toxicity are used to developing new anti-AD agents. Flavonoids 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 29026987-4 2018 AChE is a physiological marker of organophosphate/carbamate pesticide exposures that may take up to 3 months to normalize after its inhibition. Organophosphates 34-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 29026987-4 2018 AChE is a physiological marker of organophosphate/carbamate pesticide exposures that may take up to 3 months to normalize after its inhibition. Carbamates 50-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 29182921-2 2018 Their design envisaged mainly to mimic the donepezil drug, a marketed inhibitor of acetylcholinesterase (AChE), and to endow the conjugate molecules with extra-properties such as metal chelation, radical scavenging and inhibition of amyloid peptide (Abeta) aggregation. Donepezil 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 29182921-2 2018 Their design envisaged mainly to mimic the donepezil drug, a marketed inhibitor of acetylcholinesterase (AChE), and to endow the conjugate molecules with extra-properties such as metal chelation, radical scavenging and inhibition of amyloid peptide (Abeta) aggregation. Donepezil 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 29182921-5 2018 The closest similarity with donepezil, in terms of AChE inhibitory activity, was obtained for the O-benzyl-hydroxypyridinone hybrids containing a 2-methylene linker, although still less active than the drug. Donepezil 28-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 29182921-5 2018 The closest similarity with donepezil, in terms of AChE inhibitory activity, was obtained for the O-benzyl-hydroxypyridinone hybrids containing a 2-methylene linker, although still less active than the drug. o-benzyl-hydroxypyridinone 98-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 29406992-3 2018 In a recent study, it has been demonstrated that purine nucleotides and uric acid alter the activity of acetylcholinesterase (AChE). Purine Nucleotides 49-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 29406992-3 2018 In a recent study, it has been demonstrated that purine nucleotides and uric acid alter the activity of acetylcholinesterase (AChE). Purine Nucleotides 49-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 29406992-3 2018 In a recent study, it has been demonstrated that purine nucleotides and uric acid alter the activity of acetylcholinesterase (AChE). Uric Acid 72-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 29406992-3 2018 In a recent study, it has been demonstrated that purine nucleotides and uric acid alter the activity of acetylcholinesterase (AChE). Uric Acid 72-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 29406992-4 2018 Thus, we hypothesize that adenine, hypoxanthine, xanthine, 2,8-dihydroxyadenine and uric acid may potentially interfere with the activity of AChE. Adenine 26-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 29406992-4 2018 Thus, we hypothesize that adenine, hypoxanthine, xanthine, 2,8-dihydroxyadenine and uric acid may potentially interfere with the activity of AChE. Hypoxanthine 35-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 29406992-4 2018 Thus, we hypothesize that adenine, hypoxanthine, xanthine, 2,8-dihydroxyadenine and uric acid may potentially interfere with the activity of AChE. Xanthine 39-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 29406992-4 2018 Thus, we hypothesize that adenine, hypoxanthine, xanthine, 2,8-dihydroxyadenine and uric acid may potentially interfere with the activity of AChE. 2,8-dihydroxyadenine 59-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 29406992-4 2018 Thus, we hypothesize that adenine, hypoxanthine, xanthine, 2,8-dihydroxyadenine and uric acid may potentially interfere with the activity of AChE. Uric Acid 84-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 29406992-6 2018 Uric acid has been found to be the most potent inhibitor of AChE, with a binding affinity higher than the known inhibitors of the enzyme. Uric Acid 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 29406992-7 2018 Further, since depleted AChE activity is associated with dementia and cognitive impairment, the present study suggest that disturbed purine nucleotide metabolism in CKD is a risk factor for cognitive impairment. Purine Nucleotides 133-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 29136790-0 2018 Paper-based amperometric sensor for determination of acetylcholinesterase using screen-printed graphene electrode. Graphite 95-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 29136790-3 2018 The amperometric detection of AChE is based on the determination of thiocholine (TCh) produced from hydrolysis of acetylthiocholine chloride (ATCh) by AChE. Thiocholine 68-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 29136790-3 2018 The amperometric detection of AChE is based on the determination of thiocholine (TCh) produced from hydrolysis of acetylthiocholine chloride (ATCh) by AChE. Thiocholine 68-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 29136790-3 2018 The amperometric detection of AChE is based on the determination of thiocholine (TCh) produced from hydrolysis of acetylthiocholine chloride (ATCh) by AChE. Thiocholine 81-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 29136790-3 2018 The amperometric detection of AChE is based on the determination of thiocholine (TCh) produced from hydrolysis of acetylthiocholine chloride (ATCh) by AChE. Thiocholine 81-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 29136790-3 2018 The amperometric detection of AChE is based on the determination of thiocholine (TCh) produced from hydrolysis of acetylthiocholine chloride (ATCh) by AChE. Acetylthiocholine chloride 114-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 29136790-3 2018 The amperometric detection of AChE is based on the determination of thiocholine (TCh) produced from hydrolysis of acetylthiocholine chloride (ATCh) by AChE. Acetylthiocholine chloride 114-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 29136790-3 2018 The amperometric detection of AChE is based on the determination of thiocholine (TCh) produced from hydrolysis of acetylthiocholine chloride (ATCh) by AChE. atch 142-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 29136790-3 2018 The amperometric detection of AChE is based on the determination of thiocholine (TCh) produced from hydrolysis of acetylthiocholine chloride (ATCh) by AChE. atch 142-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 29136790-5 2018 To avoid interference, glutathione (GSH), the potential of 0.5V vs. Ag/AgCl was applied onto a graphene electrode and the current, which depends on AChE concentration, was measured. Glutathione 23-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 29136790-5 2018 To avoid interference, glutathione (GSH), the potential of 0.5V vs. Ag/AgCl was applied onto a graphene electrode and the current, which depends on AChE concentration, was measured. Glutathione 36-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 29136790-5 2018 To avoid interference, glutathione (GSH), the potential of 0.5V vs. Ag/AgCl was applied onto a graphene electrode and the current, which depends on AChE concentration, was measured. Graphite 95-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 28822269-2 2018 The fluorescence intensity of thioflavin-T (ThT) bound in the active site of acetylcholinesterase (AChE) quenches substantially in presence of standard AChEI drugs due to the dynamic replacement of the fluorophore from the AChE active site as confirmed from steady state emission as well as time-resolved fluorescence anisotropy measurement and molecular dynamics simulation in conjunction with docking calculation. thioflavin T 30-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 28822269-2 2018 The fluorescence intensity of thioflavin-T (ThT) bound in the active site of acetylcholinesterase (AChE) quenches substantially in presence of standard AChEI drugs due to the dynamic replacement of the fluorophore from the AChE active site as confirmed from steady state emission as well as time-resolved fluorescence anisotropy measurement and molecular dynamics simulation in conjunction with docking calculation. thioflavin T 30-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 28822269-2 2018 The fluorescence intensity of thioflavin-T (ThT) bound in the active site of acetylcholinesterase (AChE) quenches substantially in presence of standard AChEI drugs due to the dynamic replacement of the fluorophore from the AChE active site as confirmed from steady state emission as well as time-resolved fluorescence anisotropy measurement and molecular dynamics simulation in conjunction with docking calculation. thioflavin T 30-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 28822269-2 2018 The fluorescence intensity of thioflavin-T (ThT) bound in the active site of acetylcholinesterase (AChE) quenches substantially in presence of standard AChEI drugs due to the dynamic replacement of the fluorophore from the AChE active site as confirmed from steady state emission as well as time-resolved fluorescence anisotropy measurement and molecular dynamics simulation in conjunction with docking calculation. thioflavin T 44-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 28822269-2 2018 The fluorescence intensity of thioflavin-T (ThT) bound in the active site of acetylcholinesterase (AChE) quenches substantially in presence of standard AChEI drugs due to the dynamic replacement of the fluorophore from the AChE active site as confirmed from steady state emission as well as time-resolved fluorescence anisotropy measurement and molecular dynamics simulation in conjunction with docking calculation. thioflavin T 44-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 28822269-2 2018 The fluorescence intensity of thioflavin-T (ThT) bound in the active site of acetylcholinesterase (AChE) quenches substantially in presence of standard AChEI drugs due to the dynamic replacement of the fluorophore from the AChE active site as confirmed from steady state emission as well as time-resolved fluorescence anisotropy measurement and molecular dynamics simulation in conjunction with docking calculation. thioflavin T 44-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 29321572-6 2018 The difference in action observed for C547 and pyridostigmine we attribute to a high level of pharmacological selectivity of C547 in inhibiting acetylcholinesterase as compared to butyrylcholinesterase. Pyridostigmine Bromide 47-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-164 29172437-1 2018 Toxicity from acute exposure to nerve agents and organophosphorus toxicants is due to irreversible inhibition of acetylcholinesterase (AChE) in the nervous system. organophosphorus 49-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-133 29172437-1 2018 Toxicity from acute exposure to nerve agents and organophosphorus toxicants is due to irreversible inhibition of acetylcholinesterase (AChE) in the nervous system. organophosphorus 49-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 29172437-5 2018 AChE was solubilized from frozen RBC by addition of 1% Triton X-100. Octoxynol 55-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 29172437-9 2018 Denatured AChE was eluted with 1% trifluoroacetic acid. Trifluoroacetic Acid 34-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-14 29623856-6 2018 RESULTS: Our experiments showed that AChE activity was increased in response to ACh in undifferentiated K562 cells, but in the erythroid differentiated K562 cells a high concentration of ACh (1 mM) decreased the AChE activity. Acetylcholine 37-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 212-216 29623856-6 2018 RESULTS: Our experiments showed that AChE activity was increased in response to ACh in undifferentiated K562 cells, but in the erythroid differentiated K562 cells a high concentration of ACh (1 mM) decreased the AChE activity. Acetylcholine 80-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 29623856-9 2018 Choline uptake inhibition by hemicholinium did increase the AChE activity but not in the erythroid differentiated K562 cell line. Choline 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 29623856-9 2018 Choline uptake inhibition by hemicholinium did increase the AChE activity but not in the erythroid differentiated K562 cell line. Hemicholinium 3 29-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 29195794-0 2018 Design, synthesis and pharmacological evaluation of some novel indanone derivatives as acetylcholinesterase inhibitors for the management of cognitive dysfunction. indacrinone 63-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 29737870-2 2018 We hypothesized that donepezil, an acetylcholinesterase inhibitor, would enhance cognitive recovery beyond that of usual care in an acute rehabilitation facility. Donepezil 21-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 29660899-6 2018 Correlation coefficient between AChE and NTA (r= 0.79, P< 0.001) was greater than that between BCA and NTA (r= 0.64, P= 0.003). 2-naphthylthiolacetate 41-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 29367595-7 2018 Molecular docking studies showed that the compounds could combine with the active site of AChE by the pi-pi or cation-pi action between the carboline ring and the phenyl rings of the residues, and the beta-carboline moiety is embedded in a cavity surrounded by four aromatic residues of Trp86, Tyr337, Trp439 and Tyr449. Carbolines 140-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 29367595-7 2018 Molecular docking studies showed that the compounds could combine with the active site of AChE by the pi-pi or cation-pi action between the carboline ring and the phenyl rings of the residues, and the beta-carboline moiety is embedded in a cavity surrounded by four aromatic residues of Trp86, Tyr337, Trp439 and Tyr449. norharman 201-215 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 29367595-9 2018 Thus, 2-aryl-9-methyl-beta-carboliniums emerged as novel and promising tool compounds for the development of new AChE inhibitor agents. 2-aryl-9-methyl-beta-carboliniums 6-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 29630536-3 2018 In healthy human red blood cells (RBCs), timolol is an inhibitor of AChE and induces NO efflux and GSNO efflux from that blood component in lower concentration than those obtained in presence of the natural AChE substrate, acetylcholine (ACh). Timolol 41-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 29630536-3 2018 In healthy human red blood cells (RBCs), timolol is an inhibitor of AChE and induces NO efflux and GSNO efflux from that blood component in lower concentration than those obtained in presence of the natural AChE substrate, acetylcholine (ACh). Timolol 41-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 207-211 29630536-4 2018 The signal transduction pathway in RBCs described for NO in dependence of AChE-ACh active complex involves Gi protein, protein tyrosine kinase (PTK like Syk and p53/56Lyn), protein tyrosine phosphatase (PTP) and adenylyl cyclase (AC).The aim of this in vitro study was to verify the effect of timolol maleate in ED, NO efflux and NO derivatives molecules (NOx) like nitrite (NO2-), nitrate (NO3-, peroxynitrite (-ONOO) and GSNO under the presence of PTK, PTP, AC and guanylyl cyclase (GC) enzyme proteins inhibitors.Blood samples from healthy donors were each one divided and were performed aliquots in absence (control aliquots) and presence of timolol or timolol plus each inhibitor and Gi protein uncoupling. Timolol 293-300 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 29630536-4 2018 The signal transduction pathway in RBCs described for NO in dependence of AChE-ACh active complex involves Gi protein, protein tyrosine kinase (PTK like Syk and p53/56Lyn), protein tyrosine phosphatase (PTP) and adenylyl cyclase (AC).The aim of this in vitro study was to verify the effect of timolol maleate in ED, NO efflux and NO derivatives molecules (NOx) like nitrite (NO2-), nitrate (NO3-, peroxynitrite (-ONOO) and GSNO under the presence of PTK, PTP, AC and guanylyl cyclase (GC) enzyme proteins inhibitors.Blood samples from healthy donors were each one divided and were performed aliquots in absence (control aliquots) and presence of timolol or timolol plus each inhibitor and Gi protein uncoupling. Timolol 646-653 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 29173156-8 2018 The RMSD and MM-GBSA results from molecular dymamic simulations indicated that the docking pose of diosmetin-AChE complex displayed highly stable, which can be used for validating the accuracy of molecular docking study. diosmetin 99-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 29173156-10 2018 CONCLUSION: The obtained results revealed that all the four compounds exhibited modest AChE inhibitory activity, among which Diosmetin manifested remarkable anti-AChE activity, comparable with the reference compound, Physostigmine. diosmetin 125-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 29173156-10 2018 CONCLUSION: The obtained results revealed that all the four compounds exhibited modest AChE inhibitory activity, among which Diosmetin manifested remarkable anti-AChE activity, comparable with the reference compound, Physostigmine. diosmetin 125-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-166 29189157-2 2018 In this review, the role of phenolic acids as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) is discussed, including the structure-activity relationship. phenolic acid 28-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 29189157-2 2018 In this review, the role of phenolic acids as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) is discussed, including the structure-activity relationship. phenolic acid 28-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 29564983-0 2018 Molecular Docking and Dynamic Simulation Studies of Terpenoids of I. wightii (Bentham) H. Hara against Acetylcholinesterase and Histone Deacetylase3 Receptors. Terpenes 52-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 29564983-3 2018 OBJECTIVE: In silico and in vitro approaches were attempted to screen bioactive terpenoids isolated from Isodon wightii with acetylcholinesterase and histone deacetylase3 receptors. Terpenes 80-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 29564983-4 2018 METHODS: Terpenoids such as abietic acid, oleanolic acid, alpha-amyrin acetate, beta-amyrin acetate were docked with AchE and HDAC3 receptors using AutoDock Vina (version 1.1.2). Terpenes 9-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 29564983-4 2018 METHODS: Terpenoids such as abietic acid, oleanolic acid, alpha-amyrin acetate, beta-amyrin acetate were docked with AchE and HDAC3 receptors using AutoDock Vina (version 1.1.2). abietic acid 28-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 29564983-4 2018 METHODS: Terpenoids such as abietic acid, oleanolic acid, alpha-amyrin acetate, beta-amyrin acetate were docked with AchE and HDAC3 receptors using AutoDock Vina (version 1.1.2). Oleanolic Acid 42-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 29564983-4 2018 METHODS: Terpenoids such as abietic acid, oleanolic acid, alpha-amyrin acetate, beta-amyrin acetate were docked with AchE and HDAC3 receptors using AutoDock Vina (version 1.1.2). beta-amyrin acetate 58-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 29564983-4 2018 METHODS: Terpenoids such as abietic acid, oleanolic acid, alpha-amyrin acetate, beta-amyrin acetate were docked with AchE and HDAC3 receptors using AutoDock Vina (version 1.1.2). beta-amyrin acetate 80-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 29564983-7 2018 RESULTS: Ligplot analysis indicated that abietic acid had strong binding efficiency with AchE and HDAC3 receptors forming one and four hydrogen bonds respectively. abietic acid 41-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 29564983-7 2018 RESULTS: Ligplot analysis indicated that abietic acid had strong binding efficiency with AchE and HDAC3 receptors forming one and four hydrogen bonds respectively. Hydrogen 135-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 29564983-10 2018 Solvent accessible surface area revealed the favourable interacting region of AchE and HDAC3 receptors with abietic acid in the range of ~215nm2 to ~235nm2 and ~157nm2 to ~175nm2 respectively. abietic acid 108-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 29852870-0 2018 Acetylcholinesterase Inhibitor Donepezil Effects on Plasma beta-Hydroxybutyrate Levels in the Treatment of Alzheimer"s Disease. Donepezil 31-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 29852870-0 2018 Acetylcholinesterase Inhibitor Donepezil Effects on Plasma beta-Hydroxybutyrate Levels in the Treatment of Alzheimer"s Disease. 3-Hydroxybutyric Acid 59-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 29852870-2 2018 Donepezil is a first-line acetylcholinesterase inhibitor used for the treatment of AD that has been found, in addition to its potent acetylcholinesterase inhibitory effect, to act through other non-cholinergic mechanisms such as affecting mitochondrial biogenesis through peroxisome proliferator-activated receptor gamma coactivator (PGC1alpha). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 29852870-2 2018 Donepezil is a first-line acetylcholinesterase inhibitor used for the treatment of AD that has been found, in addition to its potent acetylcholinesterase inhibitory effect, to act through other non-cholinergic mechanisms such as affecting mitochondrial biogenesis through peroxisome proliferator-activated receptor gamma coactivator (PGC1alpha). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 29992880-8 2018 CONCLUSION: Tacrine-quinoline hybrids 7a exhibited the highest activity towards hBChE (IC50 = 0.97 micromol) and 7d towards hAChE (IC50 = 0.32 micromol). Tacrine 12-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-129 29992880-8 2018 CONCLUSION: Tacrine-quinoline hybrids 7a exhibited the highest activity towards hBChE (IC50 = 0.97 micromol) and 7d towards hAChE (IC50 = 0.32 micromol). quinoline 20-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-129 30047333-0 2018 2D & 3D-QSAR Study on Novel Piperidine and Piperazine Derivatives as Acetylcholinesterase Enzyme Inhibitors. piperidine 28-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-96 30047333-0 2018 2D & 3D-QSAR Study on Novel Piperidine and Piperazine Derivatives as Acetylcholinesterase Enzyme Inhibitors. Piperazine 43-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-96 29303072-5 2018 The first involves the use of a photosensitizer with a high affinity for its target protein; in this case, the photosensitizer is methylene blue for acetylcholinesterase. Methylene Blue 130-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-169 29272792-0 2018 In-silico and in-vitro evaluation of human acetylcholinesterase inhibition by organophosphates. Organophosphates 78-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 29272792-1 2018 Organophosphates (OP) inhibit the acetylcholinesterase (AChE) activity and devastate the nervous system of pest however its mode of action is ubiquitous and acts similarly on human AChE (hAChE). Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 29272792-1 2018 Organophosphates (OP) inhibit the acetylcholinesterase (AChE) activity and devastate the nervous system of pest however its mode of action is ubiquitous and acts similarly on human AChE (hAChE). Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 29272792-1 2018 Organophosphates (OP) inhibit the acetylcholinesterase (AChE) activity and devastate the nervous system of pest however its mode of action is ubiquitous and acts similarly on human AChE (hAChE). Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 29272792-1 2018 Organophosphates (OP) inhibit the acetylcholinesterase (AChE) activity and devastate the nervous system of pest however its mode of action is ubiquitous and acts similarly on human AChE (hAChE). Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-192 29272792-5 2018 Investigation reported Tryptophan (Trp86) residue involved in most interactions by forming a pi-cation interaction apart from Ser203 on anionic subsite of hAChE. Tryptophan 23-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-160 29272792-8 2018 Molecular dynamic simulation (GROMACS 4.5.5) of hAChE-PEP complex for 4 x 104 pico-second with SPC16 water system at 310 K temperature explained the evident role of Trp86 in stabilizing the ligand at P-site of the enzyme. Water 101-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-53 29126727-1 2018 New 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives are proposed as dual-target-directed monoamine oxidase B (MAO-B) and acetylcholinesterase (AChE) inhibitors, as well as antioxidant agents, for the treatment of neurodegenerative disorders such as Parkinson"s disease. 4-(3-nitrophenyl)thiazol-2-ylhydrazone 4-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 29126727-1 2018 New 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives are proposed as dual-target-directed monoamine oxidase B (MAO-B) and acetylcholinesterase (AChE) inhibitors, as well as antioxidant agents, for the treatment of neurodegenerative disorders such as Parkinson"s disease. 4-(3-nitrophenyl)thiazol-2-ylhydrazone 4-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 28930602-2 2018 Organophosphate (OP) acaricides target acetylcholinesterase (AChE) critical to tick central nervous system function. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 28930602-2 2018 Organophosphate (OP) acaricides target acetylcholinesterase (AChE) critical to tick central nervous system function. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 29562505-3 2018 OBJECTIVE: The objective of the present study was to illustrate the regional differences of brain acetylcholinesterase (AChE) activity as quantified by N-[11C]methylpiperidinyl-4-acetate ([11C]MP4A) and PET using parametric whole brain analysis and clarify those differences as a function of age. n-[11c]methylpiperidinyl-4-acetate 152-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-118 29562505-3 2018 OBJECTIVE: The objective of the present study was to illustrate the regional differences of brain acetylcholinesterase (AChE) activity as quantified by N-[11C]methylpiperidinyl-4-acetate ([11C]MP4A) and PET using parametric whole brain analysis and clarify those differences as a function of age. n-[11c]methylpiperidinyl-4-acetate 152-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 29131470-0 2018 Synthesis of some novel pyridine compounds containing bis-1,2,4-triazole/thiosemicarbazide moiety and investigation of their antioxidant properties, carbonic anhydrase, and acetylcholinesterase enzymes inhibition profiles. pyridine 24-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-193 29149534-0 2018 Novel N-propylphthalimide- and 4-vinylbenzyl-substituted benzimidazole salts: Synthesis, characterization, and determination of their metal chelating effects and inhibition profiles against acetylcholinesterase and carbonic anhydrase enzymes. n-propylphthalimide- and 4-vinylbenzyl-substituted benzimidazole salts 6-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 190-210 29149534-5 2018 Additionally, tacrine inhibited AChE and obtained a Ki value of 174.6 nM. Tacrine 14-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 29286595-1 2018 OBJECTIVE: To examine whether galantamine, a cognitive-enhancing medication that is both acetylcholinesterase inhibitor and agonist at nicotinic acetylcholine receptors, is effective at improving cocaine use outcomes and cognitive functioning, alone and in combination with computerized cognitive behavioral therapy (CBT). Galantamine 30-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 29406108-7 2018 We further confirmed that hsa-miR-146b-5p significantly suppressed acetylcholinesterase (AChE) activity and targeted the 3"-untranslated region of the AChE T subunit, which has been down-regulated in dioxin treated SK-N-SH cells. Dioxins 200-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 29406108-7 2018 We further confirmed that hsa-miR-146b-5p significantly suppressed acetylcholinesterase (AChE) activity and targeted the 3"-untranslated region of the AChE T subunit, which has been down-regulated in dioxin treated SK-N-SH cells. Dioxins 200-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 29406108-7 2018 We further confirmed that hsa-miR-146b-5p significantly suppressed acetylcholinesterase (AChE) activity and targeted the 3"-untranslated region of the AChE T subunit, which has been down-regulated in dioxin treated SK-N-SH cells. sk-n 215-219 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 29406108-8 2018 Functional bioinformatic analysis showed that the known and predicted target genes of hsa-miR-146b-5p were involved in some brain functions or cyto-toxicities related to known dioxin effects, including synapse transmission, in which AChE may serve as a responsive gene for mediating the effect. Dioxins 176-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-237 29842826-0 2018 Effects of cyclodextrin on the stereoselectivity inhibition of acetylcholinesterase by isomalathion. Cyclodextrins 11-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 29842826-3 2018 It was speculated that higher electronic cloud density and lower water solubility of beta-CD than alpha-CD and RAMEB might favor to combination between acetylcholinesterase (AChE) and isomalathion included by beta-CD. Water 65-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 29842826-3 2018 It was speculated that higher electronic cloud density and lower water solubility of beta-CD than alpha-CD and RAMEB might favor to combination between acetylcholinesterase (AChE) and isomalathion included by beta-CD. Water 65-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 29842826-3 2018 It was speculated that higher electronic cloud density and lower water solubility of beta-CD than alpha-CD and RAMEB might favor to combination between acetylcholinesterase (AChE) and isomalathion included by beta-CD. betadex 85-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 29842826-3 2018 It was speculated that higher electronic cloud density and lower water solubility of beta-CD than alpha-CD and RAMEB might favor to combination between acetylcholinesterase (AChE) and isomalathion included by beta-CD. betadex 85-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 29842826-3 2018 It was speculated that higher electronic cloud density and lower water solubility of beta-CD than alpha-CD and RAMEB might favor to combination between acetylcholinesterase (AChE) and isomalathion included by beta-CD. alpha-cyclodextrin 98-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 29842826-3 2018 It was speculated that higher electronic cloud density and lower water solubility of beta-CD than alpha-CD and RAMEB might favor to combination between acetylcholinesterase (AChE) and isomalathion included by beta-CD. alpha-cyclodextrin 98-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 29842826-3 2018 It was speculated that higher electronic cloud density and lower water solubility of beta-CD than alpha-CD and RAMEB might favor to combination between acetylcholinesterase (AChE) and isomalathion included by beta-CD. betadex 209-216 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 29842826-3 2018 It was speculated that higher electronic cloud density and lower water solubility of beta-CD than alpha-CD and RAMEB might favor to combination between acetylcholinesterase (AChE) and isomalathion included by beta-CD. betadex 209-216 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 29332594-0 2018 In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley? organophosphorus 89-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 28060207-5 2018 DESIGN: Cholinergic function was assessed with [methyl-C] N-methylpiperidyl-4-acetate-PET (C-MP4A-PET), which reflects the activity of the acetylcholinesterase (AChE) enzyme. [methyl-c] n-methylpiperidyl-4-acetate 47-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-159 28060207-5 2018 DESIGN: Cholinergic function was assessed with [methyl-C] N-methylpiperidyl-4-acetate-PET (C-MP4A-PET), which reflects the activity of the acetylcholinesterase (AChE) enzyme. [methyl-c] n-methylpiperidyl-4-acetate 47-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-165 28060207-10 2018 After rivastigmine treatment, AChE activity was notably lower throughout the cortex in both respondents and nonrespondents, without significant differences between them. Rivastigmine 6-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 30178271-10 2018 Several new polymeric alkaloids were found to lack cytotoxicity against a number of human cancer cell lines, although two of them showed moderate aphicidal activity and one exhibited weak to moderate acetylcholinesterase inhibition. Alkaloids 22-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-220 29017007-0 2017 DMSO: A Mixed-Competitive Inhibitor of Human Acetylcholinesterase. Dimethyl Sulfoxide 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 28722512-5 2018 In silico the molecular interactions between AChE and oximes were examined and binding energies were assessed. Oximes 54-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 28722512-7 2018 In vitro the intrinsic ability of the oximes to inhibit AChE (IC50) and their reactivation potency (R50) when used in paraoxon inhibited human RBC-AChE was determined. Oximes 38-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 28722512-7 2018 In vitro the intrinsic ability of the oximes to inhibit AChE (IC50) and their reactivation potency (R50) when used in paraoxon inhibited human RBC-AChE was determined. Oximes 38-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 28722512-7 2018 In vitro the intrinsic ability of the oximes to inhibit AChE (IC50) and their reactivation potency (R50) when used in paraoxon inhibited human RBC-AChE was determined. Paraoxon 118-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 29017007-3 2017 Here, we report the detailed biochemical analysis of the effects of DMSO on the human acetylcholine-degrading enzyme, acetylcholinesterase (AChE), the primary target of current Alzheimer"s therapeutics. Dimethyl Sulfoxide 68-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 29017007-3 2017 Here, we report the detailed biochemical analysis of the effects of DMSO on the human acetylcholine-degrading enzyme, acetylcholinesterase (AChE), the primary target of current Alzheimer"s therapeutics. Dimethyl Sulfoxide 68-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 29017007-3 2017 Here, we report the detailed biochemical analysis of the effects of DMSO on the human acetylcholine-degrading enzyme, acetylcholinesterase (AChE), the primary target of current Alzheimer"s therapeutics. Acetylcholine 86-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 29017007-3 2017 Here, we report the detailed biochemical analysis of the effects of DMSO on the human acetylcholine-degrading enzyme, acetylcholinesterase (AChE), the primary target of current Alzheimer"s therapeutics. Acetylcholine 86-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 29017007-4 2017 Our analysis showed that DMSO is a considerably potent and highly selective irreversible mixed-competitive inhibitor of human AChE with IC50 values in the lower millimolar range, corresponding to 0.88% to 2.6% DMSO (v/v). Dimethyl Sulfoxide 25-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 29017007-4 2017 Our analysis showed that DMSO is a considerably potent and highly selective irreversible mixed-competitive inhibitor of human AChE with IC50 values in the lower millimolar range, corresponding to 0.88% to 2.6% DMSO (v/v). Dimethyl Sulfoxide 210-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 29017007-5 2017 Most importantly, 1-4% (v/v) DMSO, the commonly used experimental concentrations, showed ~37-80% inhibition of human AChE activity. Dimethyl Sulfoxide 29-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 29267246-5 2017 For this preliminary report, a total of 14 (i.e., 4,5-dimethoxy-2-nitrobenzohydrazide plus 1-(1-benzylpiperidin-4-yl)ethan-1-one) derivatives were synthesized and screened, in silico and in vitro, for their ability to scavenge free radicals and inhibit acetylcholinesterase (AChE)/butyrylcholinesterase (BuChE) enzymes. SCHEMBL16377398 50-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 253-273 29267246-5 2017 For this preliminary report, a total of 14 (i.e., 4,5-dimethoxy-2-nitrobenzohydrazide plus 1-(1-benzylpiperidin-4-yl)ethan-1-one) derivatives were synthesized and screened, in silico and in vitro, for their ability to scavenge free radicals and inhibit acetylcholinesterase (AChE)/butyrylcholinesterase (BuChE) enzymes. SCHEMBL16377398 50-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 275-279 29267246-5 2017 For this preliminary report, a total of 14 (i.e., 4,5-dimethoxy-2-nitrobenzohydrazide plus 1-(1-benzylpiperidin-4-yl)ethan-1-one) derivatives were synthesized and screened, in silico and in vitro, for their ability to scavenge free radicals and inhibit acetylcholinesterase (AChE)/butyrylcholinesterase (BuChE) enzymes. 1-(1-benzylpiperidin-4-yl)ethanone 91-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 253-273 29267246-5 2017 For this preliminary report, a total of 14 (i.e., 4,5-dimethoxy-2-nitrobenzohydrazide plus 1-(1-benzylpiperidin-4-yl)ethan-1-one) derivatives were synthesized and screened, in silico and in vitro, for their ability to scavenge free radicals and inhibit acetylcholinesterase (AChE)/butyrylcholinesterase (BuChE) enzymes. 1-(1-benzylpiperidin-4-yl)ethanone 91-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 275-279 29137457-1 2017 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are irreversibly inhibited by organophosphorus pesticides through formation of a covalent bond with the active site serine. organophosphorus 91-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 29137457-1 2017 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are irreversibly inhibited by organophosphorus pesticides through formation of a covalent bond with the active site serine. organophosphorus 91-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 29137457-1 2017 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are irreversibly inhibited by organophosphorus pesticides through formation of a covalent bond with the active site serine. Serine 177-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 29137457-1 2017 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are irreversibly inhibited by organophosphorus pesticides through formation of a covalent bond with the active site serine. Serine 177-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 29031067-0 2017 New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation. pyridine 4-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 29240773-10 2017 Further, the results of this study suggest that schistosome AChE is a target of ruthenium drugs, a finding that can inform modification of current compounds to identify analogues which are even more effective and selective against schistosomes. Ruthenium 80-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 28963904-0 2017 Design, synthesis and biological evaluation of 1,3-dihydroxyxanthone derivatives: Effective agents against acetylcholinesterase. 1,3-dihydroxy-xanthone 47-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 28963904-1 2017 The present work concerns the rational design and development of new inhibitors of acetylcholinesterase (AChE) based on the privileged xanthone scaffold. xanthone 135-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 28963904-1 2017 The present work concerns the rational design and development of new inhibitors of acetylcholinesterase (AChE) based on the privileged xanthone scaffold. xanthone 135-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 28963904-5 2017 The synthetic xanthone 11 showed the best inhibitory effect on AChE and a molecular modeling study revealed that 11 targeted both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. xanthone 14-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 28963904-5 2017 The synthetic xanthone 11 showed the best inhibitory effect on AChE and a molecular modeling study revealed that 11 targeted both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. xanthone 14-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 203-207 28963904-5 2017 The synthetic xanthone 11 showed the best inhibitory effect on AChE and a molecular modeling study revealed that 11 targeted both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. cas 157-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 28963904-5 2017 The synthetic xanthone 11 showed the best inhibitory effect on AChE and a molecular modeling study revealed that 11 targeted both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. cas 157-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 203-207 28963904-5 2017 The synthetic xanthone 11 showed the best inhibitory effect on AChE and a molecular modeling study revealed that 11 targeted both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. Aminosalicylic Acid 195-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 28963904-5 2017 The synthetic xanthone 11 showed the best inhibitory effect on AChE and a molecular modeling study revealed that 11 targeted both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. Aminosalicylic Acid 195-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 203-207 29362639-2 2017 MATERIAL AND METHODS: In a group of 35 acute poisoned patients by organophosphate compounds has led to inhibition of AchE. Organophosphates 66-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 29079494-4 2017 Moreover, bisphenols examined increased thiol groups level, caused oxidative damage to membrane proteins, decreased ATP level, depleted the activity of Na+/K + ATPase and changed the activity of AChE in human red blood cells. bis(4-hydroxyphenyl)sulfone 10-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 28902458-3 2017 In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), alpha-glucosidase (alpha-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). naringin 62-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 255-259 28902458-3 2017 In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), alpha-glucosidase (alpha-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). chrysin 15-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 255-259 28902458-3 2017 In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), alpha-glucosidase (alpha-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). chrysin 15-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-253 28902458-3 2017 In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), alpha-glucosidase (alpha-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). carvacrol 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-253 28902458-3 2017 In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), alpha-glucosidase (alpha-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). carvacrol 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 255-259 28902458-3 2017 In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), alpha-glucosidase (alpha-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). Hesperidin 35-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-253 28902458-3 2017 In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), alpha-glucosidase (alpha-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). Hesperidin 35-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 255-259 28902458-3 2017 In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), alpha-glucosidase (alpha-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). zingerone 47-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-253 28902458-3 2017 In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), alpha-glucosidase (alpha-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). zingerone 47-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 255-259 28902458-3 2017 In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), alpha-glucosidase (alpha-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). naringin 62-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-253 28902458-3 2017 In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), alpha-glucosidase (alpha-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). Phenols 82-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-253 28902458-3 2017 In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), alpha-glucosidase (alpha-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). Phenols 82-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 255-259 27897077-1 2017 Acetylcholinesterase (AChE) is an important enzyme responsible for Alzheimer"s disease, as per report, keto-enol form of curcumin inhibits this enzyme. keto-enol 103-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 27897077-1 2017 Acetylcholinesterase (AChE) is an important enzyme responsible for Alzheimer"s disease, as per report, keto-enol form of curcumin inhibits this enzyme. keto-enol 103-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 27897077-1 2017 Acetylcholinesterase (AChE) is an important enzyme responsible for Alzheimer"s disease, as per report, keto-enol form of curcumin inhibits this enzyme. Curcumin 121-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 27897077-1 2017 Acetylcholinesterase (AChE) is an important enzyme responsible for Alzheimer"s disease, as per report, keto-enol form of curcumin inhibits this enzyme. Curcumin 121-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 27766908-0 2017 Synthesis and molecular docking studies of some 4-phthalimidobenzenesulfonamide derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors. 4-phthalimidobenzenesulfonamide 48-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 27766908-1 2017 A series of 4-phthalimidobenzenesulfonamide derivatives were designed, synthesized and evaluated for the inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). 4-phthalimidobenzenesulfonamide 12-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 27766908-1 2017 A series of 4-phthalimidobenzenesulfonamide derivatives were designed, synthesized and evaluated for the inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). 4-phthalimidobenzenesulfonamide 12-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 27766908-6 2017 Molecular docking studies of the most active compound 7 in AChE showed that this compound can interact with both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. cas 140-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 27766908-6 2017 Molecular docking studies of the most active compound 7 in AChE showed that this compound can interact with both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. Aminosalicylic Acid 178-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 27766908-6 2017 Molecular docking studies of the most active compound 7 in AChE showed that this compound can interact with both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. Aminosalicylic Acid 178-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 27801600-0 2017 Tertiary amine derivatives of chlorochalcone as acetylcholinesterase (AChE) and buthylcholinesterase (BuChE) inhibitors: the influence of chlorine, alkyl amine side chain and alpha,beta-unsaturated ketone group. tertiary amine 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 27801600-0 2017 Tertiary amine derivatives of chlorochalcone as acetylcholinesterase (AChE) and buthylcholinesterase (BuChE) inhibitors: the influence of chlorine, alkyl amine side chain and alpha,beta-unsaturated ketone group. tertiary amine 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 27801600-0 2017 Tertiary amine derivatives of chlorochalcone as acetylcholinesterase (AChE) and buthylcholinesterase (BuChE) inhibitors: the influence of chlorine, alkyl amine side chain and alpha,beta-unsaturated ketone group. MLS002667767 30-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 27801600-0 2017 Tertiary amine derivatives of chlorochalcone as acetylcholinesterase (AChE) and buthylcholinesterase (BuChE) inhibitors: the influence of chlorine, alkyl amine side chain and alpha,beta-unsaturated ketone group. MLS002667767 30-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 27801600-1 2017 A new series of tertiary amine derivatives of chlorochalcone (4a~4l) were designed, synthesized and evaluated for the effect on acetylcholinesterase (AChE) and buthylcholinesterase (BuChE). MLS002667767 46-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 27801600-1 2017 A new series of tertiary amine derivatives of chlorochalcone (4a~4l) were designed, synthesized and evaluated for the effect on acetylcholinesterase (AChE) and buthylcholinesterase (BuChE). MLS002667767 46-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 27801600-6 2017 Molecular docking and enzyme kinetic study on compound 4l suggested that it simultaneously binds to the catalytic active site (CAS) and peripheral anionic site (PAS) of AChE. Aminosalicylic Acid 161-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 27801600-7 2017 Further study showed that the pyrazoline derivatives synthesized from chlorochalcones had weaker activity and lower selectivity in inhibiting AChE compared to that of chlorochalcone derivatives. pyrazoline 30-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 27801600-7 2017 Further study showed that the pyrazoline derivatives synthesized from chlorochalcones had weaker activity and lower selectivity in inhibiting AChE compared to that of chlorochalcone derivatives. chlorochalcones 70-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 27801600-7 2017 Further study showed that the pyrazoline derivatives synthesized from chlorochalcones had weaker activity and lower selectivity in inhibiting AChE compared to that of chlorochalcone derivatives. MLS002667767 70-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 28100082-5 2017 Newly synthesized hetaryl sulfonamides exhibited impressive inhibition profiles with Ki values in the range of 1.42-6.58 nM against hCA I, 1.72-7.41 nM against hCA II, 0.20-1.14 nM against AChE and 1.55-5.92 nM against BChE. hetaryl sulfonamides 18-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-193 28100082-7 2017 Additionally, tacrine showed Ki values of 25.75 +- 3.39 nM and 37.82 +- 2.08 against AChE and BChE, respectively. Tacrine 14-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 28133981-5 2017 Tacrine, which is the first acetylcholinesterase (AChE) inhibitor, has been selected as the ideal active fragment because of its simple structure, clear activity, and its superiority in the structural modification, thus it could be introduced into the overall molecular skeletons of the multi-target-directed anti-AD agents. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 28133981-5 2017 Tacrine, which is the first acetylcholinesterase (AChE) inhibitor, has been selected as the ideal active fragment because of its simple structure, clear activity, and its superiority in the structural modification, thus it could be introduced into the overall molecular skeletons of the multi-target-directed anti-AD agents. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 28274151-1 2017 Multifunctional carbamate-type acetylcholinesterase (AChE) inhibitors with anti-amyloidogenic properties like phenserine are potential therapeutic agents for Alzheimer"s disease (AD). Carbamates 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 28274151-1 2017 Multifunctional carbamate-type acetylcholinesterase (AChE) inhibitors with anti-amyloidogenic properties like phenserine are potential therapeutic agents for Alzheimer"s disease (AD). phenserine 110-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 28274151-4 2017 (-)-Meptazinol carbamates that superimposed well upon the model were designed and synthesized, which exhibited nanomolar AChE inhibitory potency and good anti-amyloidogenic properties in in vitro test. (-)-meptazinol carbamates 0-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 28274151-5 2017 The phenylcarbamate 43 was highly potent (IC50 31.6 nM) and slightly selective for AChE, and showed low acute toxicity. Phenylcarbamates 4-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 28718678-0 2017 Discovery of novel isoflavone derivatives as AChE/BuChE dual-targeted inhibitors: synthesis, biological evaluation and molecular modelling. Isoflavones 19-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 28718678-2 2017 In this study, we synthesised a series of novel isoflavone derivatives based on our hit compound G from in silico high-throughput screening and then tested their activities by in vitro AChE and BuChE bioassays. Isoflavones 48-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 185-189 28718678-3 2017 Most of the isoflavone derivatives displayed moderate inhibition against both AChE and BuChE. Isoflavones 12-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 28993014-5 2017 LA-GPE reduced Abeta-induced AChE activity and oxidative stress, suggesting it as a multifunctional compound potentially valuable for the treatment of Alzheimer"s disease (AD). la-gpe 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 28993014-5 2017 LA-GPE reduced Abeta-induced AChE activity and oxidative stress, suggesting it as a multifunctional compound potentially valuable for the treatment of Alzheimer"s disease (AD). UNII-042A8N37WH 15-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 28279126-3 2017 OBJECTIVE: This work focuses on the screening of acetylcholinesterase inhibitory (AChE) and mutagenic activities of the acetone extract (obtained by maceration) of the freshwater sponge Ochridaspongia rotunda Arndt (Malawispongiidae) in vitro. Acetone 120-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 28279126-3 2017 OBJECTIVE: This work focuses on the screening of acetylcholinesterase inhibitory (AChE) and mutagenic activities of the acetone extract (obtained by maceration) of the freshwater sponge Ochridaspongia rotunda Arndt (Malawispongiidae) in vitro. Acetone 120-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 28589443-8 2017 Furthermore, there is also some evidence that metformin decreases the activity of acetylcholinesterase (AChE), which is responsible for the degradation of acetylcholine (Ach), a neurotransmitter involved in the process of learning and memory. Metformin 46-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 28589443-8 2017 Furthermore, there is also some evidence that metformin decreases the activity of acetylcholinesterase (AChE), which is responsible for the degradation of acetylcholine (Ach), a neurotransmitter involved in the process of learning and memory. Metformin 46-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 28589443-8 2017 Furthermore, there is also some evidence that metformin decreases the activity of acetylcholinesterase (AChE), which is responsible for the degradation of acetylcholine (Ach), a neurotransmitter involved in the process of learning and memory. Acetylcholine 82-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 28589443-8 2017 Furthermore, there is also some evidence that metformin decreases the activity of acetylcholinesterase (AChE), which is responsible for the degradation of acetylcholine (Ach), a neurotransmitter involved in the process of learning and memory. Acetylcholine 170-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 28589443-8 2017 Furthermore, there is also some evidence that metformin decreases the activity of acetylcholinesterase (AChE), which is responsible for the degradation of acetylcholine (Ach), a neurotransmitter involved in the process of learning and memory. Acetylcholine 170-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 29186056-1 2017 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) hydrolyze the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission. Acetylcholine 92-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 29186056-1 2017 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) hydrolyze the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission. Acetylcholine 92-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 29135926-4 2017 All the compounds showed rather moderate inhibitory effect against AChE; benzyl (2S)-2-[(2-chlorophenyl)carbamoyl]pyrrolidine-1-carboxylate (IC50 = 46.35 muM) was the most potent agent. benzyl (2s)-2-[(2-chlorophenyl)carbamoyl]pyrrolidine-1-carboxylate 73-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 28923380-3 2017 In particular, compounds 12h, 12n, and 12q showed promising inhibitory activity for hAChE, with IC50 values of 5.31 +- 2.8, 4.09 +- 0.23, and 7.61 +- 0.53 nM, respectively. 12-hydroxydodecanoic acid 25-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-89 28923380-3 2017 In particular, compounds 12h, 12n, and 12q showed promising inhibitory activity for hAChE, with IC50 values of 5.31 +- 2.8, 4.09 +- 0.23, and 7.61 +- 0.53 nM, respectively. 12-nitroxide stearate 30-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-89 28923380-3 2017 In particular, compounds 12h, 12n, and 12q showed promising inhibitory activity for hAChE, with IC50 values of 5.31 +- 2.8, 4.09 +- 0.23, and 7.61 +- 0.53 nM, respectively. 12q 39-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-89 28923380-5 2017 Moreover, enzyme kinetics confirmed that compound 12q caused a mixed type of AChE inhibition, by binding to both the active sites (PAS and CAS) of AChE. 12q 50-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 28923380-5 2017 Moreover, enzyme kinetics confirmed that compound 12q caused a mixed type of AChE inhibition, by binding to both the active sites (PAS and CAS) of AChE. 12q 50-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 29099058-0 2017 Diverse Effects of an Acetylcholinesterase Inhibitor, Donepezil, on Hippocampal Neuronal Death after Pilocarpine-Induced Seizure. Donepezil 54-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 29099058-0 2017 Diverse Effects of an Acetylcholinesterase Inhibitor, Donepezil, on Hippocampal Neuronal Death after Pilocarpine-Induced Seizure. Pilocarpine 101-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 29099058-3 2017 Donepezil is an acetylcholinesterase inhibitor and is an effective treatment agent for Alzheimer"s disease. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 28940630-0 2017 Synthesis, Molecular Modeling, and Evaluation of Novel Sulfonylhydrazones as Acetylcholinesterase Inhibitors for Alzheimer"s Disease. sulfonylhydrazones 55-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 28940630-3 2017 Three series of sulfonylhydrazone compounds were designed, and their ability to inhibit AChE was evaluated. sulfonylhydrazone 16-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 28940630-6 2017 Molecular dynamics studies of compound 6d showed that the interaction with the peripheral binding site of AChE was similar to donepezil, which may explain its low IC50 (0.64 muM). Donepezil 126-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 28986116-0 2017 9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer"s disease treatment. 9-substituted acridine 0-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 28986116-1 2017 We investigated the inhibitory activity of 4 groups of novel acridine derivatives against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and carboxylesterase (CaE) using the methods of enzyme kinetics and molecular docking. Acridines 61-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 28374576-0 2017 Docking-based design and synthesis of galantamine-camphane hybrids as inhibitors of acetylcholinesterase. Galantamine 38-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 29066970-6 2017 The membrane bound AChE, solubilized from human RBC with 0.6% Triton X-100, binds to Hupresin and remains bound during washing with sodium chloride. Octoxynol 62-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 29066970-6 2017 The membrane bound AChE, solubilized from human RBC with 0.6% Triton X-100, binds to Hupresin and remains bound during washing with sodium chloride. Sodium Chloride 132-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 29066970-7 2017 Human AChE is not released in significant quantities with non-denaturing solvents, but is recovered in 1% trifluoroacetic acid. Trifluoroacetic Acid 106-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 29066970-12 2017 A similar trial was conducted with red blood cell AChE in 0.6% Triton X-100. Octoxynol 63-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 28772158-0 2017 Novel antioxidant bromophenols with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions. bromophenols 18-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 28772158-5 2017 Also in the last part of this studies novel bromophenols were tested against some metabolic enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE) enzymes and carbonic anhydrase I, and II (hCA I and hCA II) isoenzymes. bromophenols 44-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 28772158-5 2017 Also in the last part of this studies novel bromophenols were tested against some metabolic enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE) enzymes and carbonic anhydrase I, and II (hCA I and hCA II) isoenzymes. bromophenols 44-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 28772158-6 2017 The newly synthesized bromophenols showed Ki values in a range of 6.78+-0.68 to 126.07+-35.6nM against hCA I, 4.32+-0.23 to 72.25+-12.94nM against hCA II, 4.60+-1.15 to 38.13+-5.91nM against AChE and 7.36+-1.31 to 29.38+-3.68nM against BChE. bromophenols 22-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 191-195 28866249-0 2017 The synthesis of novel sulfamides derived from beta-benzylphenethylamines as acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase enzymes inhibitors. sulfamides 23-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 28866249-0 2017 The synthesis of novel sulfamides derived from beta-benzylphenethylamines as acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase enzymes inhibitors. beta-benzylphenethylamine 47-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 28843102-5 2017 In the group exposed to organophosphates, the activity of acetylcholinesterase, butyrylcholinesterase and total cholinesterase was lower by 63.8%, 12.8%, and 14.8%, respectively, and 92.6% of the group had dialkyl phosphates present in their urine. Organophosphates 24-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 28843102-5 2017 In the group exposed to organophosphates, the activity of acetylcholinesterase, butyrylcholinesterase and total cholinesterase was lower by 63.8%, 12.8%, and 14.8%, respectively, and 92.6% of the group had dialkyl phosphates present in their urine. dialkyl phosphates 206-224 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 28601645-0 2017 Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular docking of new acridine-coumarin hybrids. acridine-coumarin 90-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 28601645-1 2017 A novel series of acridine-coumarin hybrids was synthesized and biologically evaluated for their potential inhibitory effect on both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). acridine-coumarin 18-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 28601645-1 2017 A novel series of acridine-coumarin hybrids was synthesized and biologically evaluated for their potential inhibitory effect on both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). acridine-coumarin 18-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 28601645-2 2017 The newly synthesized derivatives 9a-d have shown higher activity against human AChE (hAChE) compared with 7-MEOTA as the standard drug. 7-methoxytacrine 107-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 28601645-3 2017 Among them derivative 9b exhibited the most potent acetylcholinesterase inhibitory activity, with an IC50 value of 5.85muM compared with 7-MEOTA (IC50=15muM). 7-methoxytacrine 137-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 28800181-0 2017 Synephrine and phenylephrine act as alpha-amylase, alpha-glycosidase, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase enzymes inhibitors. Synephrine 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 28800181-0 2017 Synephrine and phenylephrine act as alpha-amylase, alpha-glycosidase, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase enzymes inhibitors. Phenylephrine 15-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 28800181-1 2017 In this paper, synephrine and phenylephrine compounds showed excellent inhibitory effects against human carbonic anhydrase (hCA) isoforms I and II, alpha-amylase, alpha-glycosidase, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). Synephrine 15-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-202 28800181-1 2017 In this paper, synephrine and phenylephrine compounds showed excellent inhibitory effects against human carbonic anhydrase (hCA) isoforms I and II, alpha-amylase, alpha-glycosidase, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). Synephrine 15-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-208 28800181-1 2017 In this paper, synephrine and phenylephrine compounds showed excellent inhibitory effects against human carbonic anhydrase (hCA) isoforms I and II, alpha-amylase, alpha-glycosidase, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). Phenylephrine 30-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-202 28800181-1 2017 In this paper, synephrine and phenylephrine compounds showed excellent inhibitory effects against human carbonic anhydrase (hCA) isoforms I and II, alpha-amylase, alpha-glycosidase, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). Phenylephrine 30-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-208 28833991-5 2017 Also, some of the bis(alpha-aminoalkyl)phosphinic acid derivatives (4a, 4e-h) showed nice inhibitory action against acetylcholinesterase and human carbonic anhydrase isoforms I and II. bis(alpha-aminoalkyl)phosphinic acid 18-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 27782777-2 2017 To date, the successful therapeutic strategy to treat AD is maintaining the levels of acetylcholine via inhibiting acetylcholinesterase (AChE). Acetylcholine 86-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 27782777-2 2017 To date, the successful therapeutic strategy to treat AD is maintaining the levels of acetylcholine via inhibiting acetylcholinesterase (AChE). Acetylcholine 86-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 27782777-3 2017 The present study involves identification of newer AChE inhibitors by dual approach of e-pharmacophore and structure-based virtual screening of Asinex library. asinex 144-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 27782777-5 2017 Among 11 selected hits, ZINC72338524 with best MM-GBSA dG binding shows optimal range of CNS properties and ligand-AChE complex stability. ZINC72338524 24-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 28387957-5 2017 Sotagliflozin appeared more promising for SGLT2 as well as AChE-inhibition with reference to DeltaG and Ki values in comparison to Ertugliflozin. (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triol 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 28387957-6 2017 The DeltaG and Ki values for "Sotagliflozin:AChE-binding" were -7.16 kcal/mol and 5.6 muM, respectively while the same were found to be -8.47 kcal/mol and 0.62 muM, respectively for its interaction with SGLT2. (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triol 30-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 28809439-7 2017 KEY FINDINGS: As expected, galanthamine-type alkaloids were the most active against hACHE; yet, lycorenine- and tazettine-type alkaloids contributed significantly, while lycorine-type alkaloids dominated the hit list against HIV-1 PR target protein and were significantly active against HIV-1 RT and influenza NA. galanthamine-type alkaloids 27-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-89 31723659-4 2017 Additionally, acetylcholinesterase aging, which is the loss of an alkyl side chain that prevents reactivation by oximes, is very rapid so that the effective reactivation by oximes is thwarted. Oximes 113-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 31723659-4 2017 Additionally, acetylcholinesterase aging, which is the loss of an alkyl side chain that prevents reactivation by oximes, is very rapid so that the effective reactivation by oximes is thwarted. Oximes 173-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 31723659-5 2017 Thus, methidathion"s effect on acetylcholinesterase inhibition is long lasting, particularly with a high dose. methidathion 6-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 28785929-0 2017 Synthesis of novel 7-aryl and 7-spiropyrazolo[4",3":5,6]pyrido[2,3-d]pyrimidine derivatives and their study as AChE inhibitors. 7-aryl and 7-spiropyrazolo[4",3":5,6]pyrido[2,3-d]pyrimidine 19-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 28985942-1 2017 Pyridostigmine bromide (PB) is a reversible acetylcholinesterase (AChE) inhibitor and the first-choice for the treatment of symptoms associated with myasthenia gravis and other neuromuscular junction disorders. Pyridostigmine Bromide 0-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 28985942-1 2017 Pyridostigmine bromide (PB) is a reversible acetylcholinesterase (AChE) inhibitor and the first-choice for the treatment of symptoms associated with myasthenia gravis and other neuromuscular junction disorders. Pyridostigmine Bromide 24-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 28985942-4 2017 As expected, a PB concentration curve based on the therapeutic dose of the drug showed an inhibition of the AChE activity. Pyridostigmine Bromide 15-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 28803044-0 2017 New racemic annulated pyrazolo[1,2-b]phthalazines as tacrine-like AChE inhibitors with potential use in Alzheimer"s disease. pyrazolo(1,2-b)phthalazine 22-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 28803044-0 2017 New racemic annulated pyrazolo[1,2-b]phthalazines as tacrine-like AChE inhibitors with potential use in Alzheimer"s disease. Tacrine 53-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 28803044-1 2017 A novel series of tacrine-like compounds 7a-u possessing a fused pyrazolo[1,2-b]phthalazine structure were designed and synthesized as potent and selective inhibitors of AChE. Tacrine 18-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 28803044-1 2017 A novel series of tacrine-like compounds 7a-u possessing a fused pyrazolo[1,2-b]phthalazine structure were designed and synthesized as potent and selective inhibitors of AChE. pyrazolo(1,2-b)phthalazine 65-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 28810188-0 2017 Novel tacrine derivatives exhibiting improved acetylcholinesterase inhibition: Design, synthesis and biological evaluation. Tacrine 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 28841514-4 2017 Herein, we report the development of a novel series of thiosemicarbazones derived from 1-benzylpiperidine, a pharmacophore within the acetylcholinesterase inhibitor, Donepezil. Thiosemicarbazones 55-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 28841514-4 2017 Herein, we report the development of a novel series of thiosemicarbazones derived from 1-benzylpiperidine, a pharmacophore within the acetylcholinesterase inhibitor, Donepezil. 1-benzylpiperidine 87-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 28841514-4 2017 Herein, we report the development of a novel series of thiosemicarbazones derived from 1-benzylpiperidine, a pharmacophore within the acetylcholinesterase inhibitor, Donepezil. Donepezil 166-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 28892361-1 2017 Nerve agents and organophosphorus pesticides make a covalent bond with the active site serine of acetylcholinesterase (AChE), resulting in inhibition of AChE activity and toxic symptoms. organophosphorus 17-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 28892361-1 2017 Nerve agents and organophosphorus pesticides make a covalent bond with the active site serine of acetylcholinesterase (AChE), resulting in inhibition of AChE activity and toxic symptoms. organophosphorus 17-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 28892361-1 2017 Nerve agents and organophosphorus pesticides make a covalent bond with the active site serine of acetylcholinesterase (AChE), resulting in inhibition of AChE activity and toxic symptoms. organophosphorus 17-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 28892361-1 2017 Nerve agents and organophosphorus pesticides make a covalent bond with the active site serine of acetylcholinesterase (AChE), resulting in inhibition of AChE activity and toxic symptoms. Serine 87-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 28892361-1 2017 Nerve agents and organophosphorus pesticides make a covalent bond with the active site serine of acetylcholinesterase (AChE), resulting in inhibition of AChE activity and toxic symptoms. Serine 87-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 28892361-1 2017 Nerve agents and organophosphorus pesticides make a covalent bond with the active site serine of acetylcholinesterase (AChE), resulting in inhibition of AChE activity and toxic symptoms. Serine 87-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 28892361-7 2017 AChE was solubilized from frozen RBCs with 1% (v/v) Triton X-100. Octoxynol 52-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 28892361-12 2017 It was concluded that all 6 monoclonal antibodies could be used to immunopurify RBC AChE and that exposure to nerve agents could be detected as adducts on the active site serine of RBC AChE. Serine 171-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 185-189 28494368-2 2017 By utilizing the acetylcholinesterase (AChE) mediated hydrolysis of acetylthiocholine to thiocholine where the activity of AChE is inhibited by the presence of organophosphate pesticides (OPPs), the subsequent thiocholine-induced aggregation of 10OsCO-Au NPs can be monitored by the change in color of the NPs solution and the variation in intensity of the SERS CO signal. Acetylthiocholine 68-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 28494368-2 2017 By utilizing the acetylcholinesterase (AChE) mediated hydrolysis of acetylthiocholine to thiocholine where the activity of AChE is inhibited by the presence of organophosphate pesticides (OPPs), the subsequent thiocholine-induced aggregation of 10OsCO-Au NPs can be monitored by the change in color of the NPs solution and the variation in intensity of the SERS CO signal. Acetylthiocholine 68-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 28494368-2 2017 By utilizing the acetylcholinesterase (AChE) mediated hydrolysis of acetylthiocholine to thiocholine where the activity of AChE is inhibited by the presence of organophosphate pesticides (OPPs), the subsequent thiocholine-induced aggregation of 10OsCO-Au NPs can be monitored by the change in color of the NPs solution and the variation in intensity of the SERS CO signal. Acetylthiocholine 68-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 28494368-2 2017 By utilizing the acetylcholinesterase (AChE) mediated hydrolysis of acetylthiocholine to thiocholine where the activity of AChE is inhibited by the presence of organophosphate pesticides (OPPs), the subsequent thiocholine-induced aggregation of 10OsCO-Au NPs can be monitored by the change in color of the NPs solution and the variation in intensity of the SERS CO signal. Thiocholine 74-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 28494368-2 2017 By utilizing the acetylcholinesterase (AChE) mediated hydrolysis of acetylthiocholine to thiocholine where the activity of AChE is inhibited by the presence of organophosphate pesticides (OPPs), the subsequent thiocholine-induced aggregation of 10OsCO-Au NPs can be monitored by the change in color of the NPs solution and the variation in intensity of the SERS CO signal. Thiocholine 74-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 28494368-2 2017 By utilizing the acetylcholinesterase (AChE) mediated hydrolysis of acetylthiocholine to thiocholine where the activity of AChE is inhibited by the presence of organophosphate pesticides (OPPs), the subsequent thiocholine-induced aggregation of 10OsCO-Au NPs can be monitored by the change in color of the NPs solution and the variation in intensity of the SERS CO signal. Thiocholine 74-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 28494368-2 2017 By utilizing the acetylcholinesterase (AChE) mediated hydrolysis of acetylthiocholine to thiocholine where the activity of AChE is inhibited by the presence of organophosphate pesticides (OPPs), the subsequent thiocholine-induced aggregation of 10OsCO-Au NPs can be monitored by the change in color of the NPs solution and the variation in intensity of the SERS CO signal. Organophosphates 160-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 28494368-2 2017 By utilizing the acetylcholinesterase (AChE) mediated hydrolysis of acetylthiocholine to thiocholine where the activity of AChE is inhibited by the presence of organophosphate pesticides (OPPs), the subsequent thiocholine-induced aggregation of 10OsCO-Au NPs can be monitored by the change in color of the NPs solution and the variation in intensity of the SERS CO signal. Organophosphates 160-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 28494368-2 2017 By utilizing the acetylcholinesterase (AChE) mediated hydrolysis of acetylthiocholine to thiocholine where the activity of AChE is inhibited by the presence of organophosphate pesticides (OPPs), the subsequent thiocholine-induced aggregation of 10OsCO-Au NPs can be monitored by the change in color of the NPs solution and the variation in intensity of the SERS CO signal. Organophosphates 160-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 28494368-2 2017 By utilizing the acetylcholinesterase (AChE) mediated hydrolysis of acetylthiocholine to thiocholine where the activity of AChE is inhibited by the presence of organophosphate pesticides (OPPs), the subsequent thiocholine-induced aggregation of 10OsCO-Au NPs can be monitored by the change in color of the NPs solution and the variation in intensity of the SERS CO signal. opps 188-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 28494368-2 2017 By utilizing the acetylcholinesterase (AChE) mediated hydrolysis of acetylthiocholine to thiocholine where the activity of AChE is inhibited by the presence of organophosphate pesticides (OPPs), the subsequent thiocholine-induced aggregation of 10OsCO-Au NPs can be monitored by the change in color of the NPs solution and the variation in intensity of the SERS CO signal. opps 188-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 28494368-2 2017 By utilizing the acetylcholinesterase (AChE) mediated hydrolysis of acetylthiocholine to thiocholine where the activity of AChE is inhibited by the presence of organophosphate pesticides (OPPs), the subsequent thiocholine-induced aggregation of 10OsCO-Au NPs can be monitored by the change in color of the NPs solution and the variation in intensity of the SERS CO signal. opps 188-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 28494368-2 2017 By utilizing the acetylcholinesterase (AChE) mediated hydrolysis of acetylthiocholine to thiocholine where the activity of AChE is inhibited by the presence of organophosphate pesticides (OPPs), the subsequent thiocholine-induced aggregation of 10OsCO-Au NPs can be monitored by the change in color of the NPs solution and the variation in intensity of the SERS CO signal. Thiocholine 89-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 28494368-2 2017 By utilizing the acetylcholinesterase (AChE) mediated hydrolysis of acetylthiocholine to thiocholine where the activity of AChE is inhibited by the presence of organophosphate pesticides (OPPs), the subsequent thiocholine-induced aggregation of 10OsCO-Au NPs can be monitored by the change in color of the NPs solution and the variation in intensity of the SERS CO signal. Thiocholine 89-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 28494368-2 2017 By utilizing the acetylcholinesterase (AChE) mediated hydrolysis of acetylthiocholine to thiocholine where the activity of AChE is inhibited by the presence of organophosphate pesticides (OPPs), the subsequent thiocholine-induced aggregation of 10OsCO-Au NPs can be monitored by the change in color of the NPs solution and the variation in intensity of the SERS CO signal. Thiocholine 89-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 28821158-6 2017 As compared with chitosan, phenolic acid-g-chitosan exhibits enhanced antioxidant, antimicrobial, antitumor, anti-allergic, anti-inflammatory, anti-diabetic and acetylcholinesterase inhibitory activities. phenolic acid-g-chitosan 27-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-181 28374576-0 2017 Docking-based design and synthesis of galantamine-camphane hybrids as inhibitors of acetylcholinesterase. camphane 50-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 28374576-1 2017 Galantamine (GAL) as an acetylcholinesterase inhibitor (AChEI) is among the main drugs approved for the treatment of Alzheimer"s disease. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 28374576-1 2017 Galantamine (GAL) as an acetylcholinesterase inhibitor (AChEI) is among the main drugs approved for the treatment of Alzheimer"s disease. Galantamine 13-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 28374576-3 2017 The amyloid beta (Abeta) peptide binds in the peripheral anionic site (PAS) at the entrance of the binding gorge of AChE and initiates the formation of amyloid plaques. Aminosalicylic Acid 71-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 28374576-4 2017 The blockade of PAS prevents from AChE-induced Abeta aggregation. Aminosalicylic Acid 16-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 28374576-10 2017 The CAM fragment of the best binders fits in the same region, proximal to PAS, where the Omega-loop of Abeta binds to AChE. Aminosalicylic Acid 74-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 28667874-3 2017 Among the medicinally important indanones, the most significant drug probably is donepezil (IV), an acetylcholinesterase (AChE) inhibitor, which has been approved by the US Food and Drug Administration for the treatment of Alzheimer"s disease (AD). Donepezil 81-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 29058298-1 2017 Huperzine A is a potent, reversible, and blood-brain barrier permeable acetylcholinesterase inhibitor. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 28497342-0 2017 Exploration of the Acetylcholinesterase Inhibitory Activity of Some Alkaloids from Amaryllidaceae Family by Molecular Docking In Silico. Alkaloids 68-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 28497342-6 2017 In this context, the purpose of this study was to apply the docking molecular in silico analysis aiming to examine the recombinant human AChE enzyme (rhAChE) inhibitory activity displayed by different alkaloids from Amaryllidaceae family. Alkaloids 201-210 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 28667874-3 2017 Among the medicinally important indanones, the most significant drug probably is donepezil (IV), an acetylcholinesterase (AChE) inhibitor, which has been approved by the US Food and Drug Administration for the treatment of Alzheimer"s disease (AD). Donepezil 81-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 28688279-2 2017 3-Chlorobenzoyl- (71) was found to be the most potent compound of this series having IC50 1.80 +- 0.11 muM for acetylcholinesterase (AChE) inhibition. 3-chlorobenzoyl- 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 28688279-2 2017 3-Chlorobenzoyl- (71) was found to be the most potent compound of this series having IC50 1.80 +- 0.11 muM for acetylcholinesterase (AChE) inhibition. 3-chlorobenzoyl- 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 28922421-2 2017 Currently approved treatments, including the acetylcholinesterase inhibitor donepezil (DON) and the N-methyl-D-aspartate antagonist memantine (MEM) provide marginal therapeutic benefits to AD patients. Donepezil 76-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 28922421-2 2017 Currently approved treatments, including the acetylcholinesterase inhibitor donepezil (DON) and the N-methyl-D-aspartate antagonist memantine (MEM) provide marginal therapeutic benefits to AD patients. Donepezil 87-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 28885588-3 2017 Beyond its function as an enzyme, a special focus is highlighted in this review for a new function of the RBC AChE, namely a component of the signal transduction pathway of nitric oxide. Nitric Oxide 173-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 32264324-1 2017 We report a delivery system based on Au-mesoporous silica (MS) nanoparticles functionalized with acetylcholinesterase on the Au face as a control unit and with disulfide-containing oligo(ethylene glycol) chains on the MS face as caps. au-mesoporous silica 37-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 28869561-1 2017 Organophosphorus agents are potent inhibitors of acetylcholinesterase. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 28419192-0 2017 Efficacy and safety of a novel acetylcholinesterase inhibitor octohydroaminoacridine in mild-to-moderate Alzheimer"s disease: a Phase II multicenter randomised controlled trial. octahydroaminoacridine 62-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 28419192-2 2017 Octohydroaminoacridine, a new AChE inhibitor, is a potential treatment for AD. octahydroaminoacridine 0-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 28668178-1 2017 Donepezil is the most commonly prescribed acetylcholinesterase inhibitor for the treatment of Alzheimer"s disease, an ailment that affects millions of older adult patients. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 28751142-5 2017 Biological results revealed that some of these compounds display good biological activities against AChE with IC50 values about 44.67-169.80nM (donepezil IC50 50.12nM). Donepezil 144-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 28544359-0 2017 Discovery of potent carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase enzymes inhibitors: The new amides and thiazolidine-4-ones synthesized on an acetophenone base. Amides 116-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 28728106-0 2017 Multipotent AChE and BACE-1 inhibitors for the treatment of Alzheimer"s disease: Design, synthesis and bio-analysis of 7-amino-1,4-dihydro-2H-isoquilin-3-one derivates. 7-amino-1,4-dihydro-2H-isoquilin-3-one 119-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-16 28728106-1 2017 In this paper, the preparation of a new class of multi-target-directed ligands (MTDLs) based on a 7-amino-1,4-dihydro-2H-isoquilin-3-one, whose lead (compound I) showed promising properties in acetylcholinesterase (AChE) inhibitory activity [1], is described. 7-amino-1,4-dihydro-2H-isoquilin-3-one 98-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-213 28728106-1 2017 In this paper, the preparation of a new class of multi-target-directed ligands (MTDLs) based on a 7-amino-1,4-dihydro-2H-isoquilin-3-one, whose lead (compound I) showed promising properties in acetylcholinesterase (AChE) inhibitory activity [1], is described. 7-amino-1,4-dihydro-2H-isoquilin-3-one 98-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 215-219 28728108-2 2017 Symmetrical homodimers bearing a dichalcogenide or selenide-based tether, the best compounds in the series, were found to be strong and highly selective electric eel AChE inhibitors, with inhibition constants within the low nanomolar range. dichalcogenide 33-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 28728108-2 2017 Symmetrical homodimers bearing a dichalcogenide or selenide-based tether, the best compounds in the series, were found to be strong and highly selective electric eel AChE inhibitors, with inhibition constants within the low nanomolar range. selenide 51-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 28711758-1 2017 In this report we assessed by docking and molecular dynamics the binding mechanisms of three FDA-approved Alzheimer drugs, inhibitors of the enzyme acetylcholinesterase (AChE): donepezil, galantamine and rivastigmine. Donepezil 177-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 28711758-1 2017 In this report we assessed by docking and molecular dynamics the binding mechanisms of three FDA-approved Alzheimer drugs, inhibitors of the enzyme acetylcholinesterase (AChE): donepezil, galantamine and rivastigmine. Galantamine 188-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 28711758-1 2017 In this report we assessed by docking and molecular dynamics the binding mechanisms of three FDA-approved Alzheimer drugs, inhibitors of the enzyme acetylcholinesterase (AChE): donepezil, galantamine and rivastigmine. Rivastigmine 204-216 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 29089996-6 2017 PT-3 (125-200 nM) inhibited scopolamine (2 mM)-induced generation of reactive oxygen species, cellular apoptosis, upregulation of acetylcholinesterase activity, downregulation of choline acetyltransferase level, and activation of p38 and JNK signalling pathways. pt-3 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 29089996-6 2017 PT-3 (125-200 nM) inhibited scopolamine (2 mM)-induced generation of reactive oxygen species, cellular apoptosis, upregulation of acetylcholinesterase activity, downregulation of choline acetyltransferase level, and activation of p38 and JNK signalling pathways. Scopolamine 28-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 28916328-10 2017 In addition, PQ induced, after 24h and 14days exposure, cell death on hippocampal neurons that was partially mediated by AChE variants alteration and cholinergic and gultamatergic transmissions disruption. Paraquat 13-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 28569609-1 2017 INTRODUCTION: organophosphorus compounds act as irreversible inhibitors of the vital enzyme acetylcholinesterase (AChE). organophosphorus 14-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 28569609-1 2017 INTRODUCTION: organophosphorus compounds act as irreversible inhibitors of the vital enzyme acetylcholinesterase (AChE). organophosphorus 14-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 28832188-4 2017 The interference of xanthone derivatives with acetylcholinesterase and other molecular targets and cellular mechanisms associated with AD have been recently systematically reported. xanthone 20-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 28613396-0 2017 Evaluation of acetylcholinesterase and carbonic anhydrase inhibition profiles of 1,2,3,4,6-pentasubstituted-4-hydroxy-cyclohexanes. 1,2,3,4,6-pentasubstituted-4-hydroxy-cyclohexanes 81-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 28867801-0 2017 An Unusual Dimeric Inhibitor of Acetylcholinesterase: Cooperative Binding of Crystal Violet. Gentian Violet 77-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 28867801-1 2017 Acetylcholinesterase (AChE) is an essential enzyme that terminates cholinergic transmission by a rapid hydrolysis of the neurotransmitter acetylcholine. Acetylcholine 138-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 28867801-1 2017 Acetylcholinesterase (AChE) is an essential enzyme that terminates cholinergic transmission by a rapid hydrolysis of the neurotransmitter acetylcholine. Acetylcholine 138-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 28867801-3 2017 In a previous high throughput screening campaign, we identified the dye crystal violet (CV) as an inhibitor of AChE. Gentian Violet 72-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 28570763-0 2017 Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties. coumarin 106-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 28570763-3 2017 With the aim of discovering novel AChE dual binders with improved drug-likeness, homo- and heterodimers containing 2H-chromen-2-one building blocks were developed. coumarin 115-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 28570763-4 2017 By exploring diverse linkages of neutral and protonatable amino moieties through aliphatic spacers of different length, a nanomolar bivalent AChE inhibitor was identified (3-[2-({4-[(dimethylamino)methyl]-2-oxo-2H-chromen-7-yl}oxy)ethoxy]-6,7-dimethoxy-2H-chromen-2-one (6 d), IC50 =59 nm) from originally weakly active fragments. 3-[2-({4-[(dimethylamino)methyl]-2-oxo-2h-chromen-7-yl}oxy)ethoxy]-6,7-dimethoxy-2h-chromen-2-one 172-269 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 28621503-1 2017 A pH-sensitive, fluorescence "turn-on" sensor based on a graphene oxide-naphthalimide (GO-NI) nanoconjugate for the detection of acetylcholine (ACh) by monitoring the enzymatic activity of acetylcholinesterase (AChE) in aqueous solution is reported. graphene oxide-naphthalimide 57-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-209 28621503-1 2017 A pH-sensitive, fluorescence "turn-on" sensor based on a graphene oxide-naphthalimide (GO-NI) nanoconjugate for the detection of acetylcholine (ACh) by monitoring the enzymatic activity of acetylcholinesterase (AChE) in aqueous solution is reported. graphene oxide-naphthalimide 57-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-215 28621503-1 2017 A pH-sensitive, fluorescence "turn-on" sensor based on a graphene oxide-naphthalimide (GO-NI) nanoconjugate for the detection of acetylcholine (ACh) by monitoring the enzymatic activity of acetylcholinesterase (AChE) in aqueous solution is reported. go-ni 87-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-209 28621503-1 2017 A pH-sensitive, fluorescence "turn-on" sensor based on a graphene oxide-naphthalimide (GO-NI) nanoconjugate for the detection of acetylcholine (ACh) by monitoring the enzymatic activity of acetylcholinesterase (AChE) in aqueous solution is reported. go-ni 87-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-215 28621503-1 2017 A pH-sensitive, fluorescence "turn-on" sensor based on a graphene oxide-naphthalimide (GO-NI) nanoconjugate for the detection of acetylcholine (ACh) by monitoring the enzymatic activity of acetylcholinesterase (AChE) in aqueous solution is reported. Acetylcholine 129-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-209 28621503-1 2017 A pH-sensitive, fluorescence "turn-on" sensor based on a graphene oxide-naphthalimide (GO-NI) nanoconjugate for the detection of acetylcholine (ACh) by monitoring the enzymatic activity of acetylcholinesterase (AChE) in aqueous solution is reported. Acetylcholine 129-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-215 28621503-1 2017 A pH-sensitive, fluorescence "turn-on" sensor based on a graphene oxide-naphthalimide (GO-NI) nanoconjugate for the detection of acetylcholine (ACh) by monitoring the enzymatic activity of acetylcholinesterase (AChE) in aqueous solution is reported. Acetylcholine 144-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-209 28621503-1 2017 A pH-sensitive, fluorescence "turn-on" sensor based on a graphene oxide-naphthalimide (GO-NI) nanoconjugate for the detection of acetylcholine (ACh) by monitoring the enzymatic activity of acetylcholinesterase (AChE) in aqueous solution is reported. Acetylcholine 144-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-215 28734356-1 2017 A highly sensitive acetylcholinesterase (AChE) electrochemical biosensor for the quantitative determination of organophosphate pesticides (OPs) in vegetables and fruits based on palladium-copper nanowires (Pd-Cu NWs) was reported. Organophosphates 111-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 28734356-1 2017 A highly sensitive acetylcholinesterase (AChE) electrochemical biosensor for the quantitative determination of organophosphate pesticides (OPs) in vegetables and fruits based on palladium-copper nanowires (Pd-Cu NWs) was reported. Organophosphates 111-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 28734356-1 2017 A highly sensitive acetylcholinesterase (AChE) electrochemical biosensor for the quantitative determination of organophosphate pesticides (OPs) in vegetables and fruits based on palladium-copper nanowires (Pd-Cu NWs) was reported. OPS 139-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 28734356-1 2017 A highly sensitive acetylcholinesterase (AChE) electrochemical biosensor for the quantitative determination of organophosphate pesticides (OPs) in vegetables and fruits based on palladium-copper nanowires (Pd-Cu NWs) was reported. OPS 139-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 28734356-1 2017 A highly sensitive acetylcholinesterase (AChE) electrochemical biosensor for the quantitative determination of organophosphate pesticides (OPs) in vegetables and fruits based on palladium-copper nanowires (Pd-Cu NWs) was reported. Palladium 178-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 28734356-1 2017 A highly sensitive acetylcholinesterase (AChE) electrochemical biosensor for the quantitative determination of organophosphate pesticides (OPs) in vegetables and fruits based on palladium-copper nanowires (Pd-Cu NWs) was reported. Palladium 178-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 28734356-1 2017 A highly sensitive acetylcholinesterase (AChE) electrochemical biosensor for the quantitative determination of organophosphate pesticides (OPs) in vegetables and fruits based on palladium-copper nanowires (Pd-Cu NWs) was reported. Copper 188-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 28734356-1 2017 A highly sensitive acetylcholinesterase (AChE) electrochemical biosensor for the quantitative determination of organophosphate pesticides (OPs) in vegetables and fruits based on palladium-copper nanowires (Pd-Cu NWs) was reported. Copper 188-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 28734356-2 2017 AChE immobilized on the modified electrode could catalyze hydrolysis of acetylthiocholine chloride (ATCl), generating an irreversible oxidation peak. Acetylthiocholine chloride 72-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 28734356-2 2017 AChE immobilized on the modified electrode could catalyze hydrolysis of acetylthiocholine chloride (ATCl), generating an irreversible oxidation peak. atcl 100-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 28734356-5 2017 The Pd-Cu NWs not only provide a large active surface area (0.268 +- 0.01) cm2 for the immobilization of AChE, which was approximately 3.8 times higher than the bare glass carbon electrode, but also exhibit excellent electro-catalytic activity and remarkable electron mobility. Carbon 172-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 28478343-4 2017 In total, seventeen compounds were synthesized in which the di-substituted triazine-triazolopyrimidine derivatives 9a-d showed better acetylcholinesterase (AChE) inhibitory activity than the corresponding tri-substituted triazine-triazolopyrimidine derivatives 10a-f. Out of the disubstituted triazine-triazolopyrimidine based compounds, 9a and 9b showed encouraging inhibitory activity on AChE with IC50 values 0.065 and 0.092 muM, respectively. di-substituted triazine 60-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-160 28478343-4 2017 In total, seventeen compounds were synthesized in which the di-substituted triazine-triazolopyrimidine derivatives 9a-d showed better acetylcholinesterase (AChE) inhibitory activity than the corresponding tri-substituted triazine-triazolopyrimidine derivatives 10a-f. Out of the disubstituted triazine-triazolopyrimidine based compounds, 9a and 9b showed encouraging inhibitory activity on AChE with IC50 values 0.065 and 0.092 muM, respectively. di-substituted triazine 60-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 390-394 28478343-4 2017 In total, seventeen compounds were synthesized in which the di-substituted triazine-triazolopyrimidine derivatives 9a-d showed better acetylcholinesterase (AChE) inhibitory activity than the corresponding tri-substituted triazine-triazolopyrimidine derivatives 10a-f. Out of the disubstituted triazine-triazolopyrimidine based compounds, 9a and 9b showed encouraging inhibitory activity on AChE with IC50 values 0.065 and 0.092 muM, respectively. triazolopyrimidine 84-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-160 28478343-4 2017 In total, seventeen compounds were synthesized in which the di-substituted triazine-triazolopyrimidine derivatives 9a-d showed better acetylcholinesterase (AChE) inhibitory activity than the corresponding tri-substituted triazine-triazolopyrimidine derivatives 10a-f. Out of the disubstituted triazine-triazolopyrimidine based compounds, 9a and 9b showed encouraging inhibitory activity on AChE with IC50 values 0.065 and 0.092 muM, respectively. triazolopyrimidine 84-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 390-394 28478343-4 2017 In total, seventeen compounds were synthesized in which the di-substituted triazine-triazolopyrimidine derivatives 9a-d showed better acetylcholinesterase (AChE) inhibitory activity than the corresponding tri-substituted triazine-triazolopyrimidine derivatives 10a-f. Out of the disubstituted triazine-triazolopyrimidine based compounds, 9a and 9b showed encouraging inhibitory activity on AChE with IC50 values 0.065 and 0.092 muM, respectively. Triazines 75-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-160 28478343-4 2017 In total, seventeen compounds were synthesized in which the di-substituted triazine-triazolopyrimidine derivatives 9a-d showed better acetylcholinesterase (AChE) inhibitory activity than the corresponding tri-substituted triazine-triazolopyrimidine derivatives 10a-f. Out of the disubstituted triazine-triazolopyrimidine based compounds, 9a and 9b showed encouraging inhibitory activity on AChE with IC50 values 0.065 and 0.092 muM, respectively. Triazines 75-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 390-394 28388529-1 2017 A pH-responsive colorimetric strategy was designed for sensitive and convenient biosensing by introducing acetylcholinesterase (AChE) catalyzed hydrolysis of acetylcholine to change solution pH and phenol red as an indicator. Acetylcholine 106-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 28388529-1 2017 A pH-responsive colorimetric strategy was designed for sensitive and convenient biosensing by introducing acetylcholinesterase (AChE) catalyzed hydrolysis of acetylcholine to change solution pH and phenol red as an indicator. Phenolsulfonphthalein 198-208 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 28388529-1 2017 A pH-responsive colorimetric strategy was designed for sensitive and convenient biosensing by introducing acetylcholinesterase (AChE) catalyzed hydrolysis of acetylcholine to change solution pH and phenol red as an indicator. Phenolsulfonphthalein 198-208 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 28684009-2 2017 It was found that salicylaldoximes were able to quickly cleave the P-S bond of organophosphate and avoid the reinhibition phenomenon in the reactivation process, but they lacked reactivating ability due to poor affinity for AChE. salicylaldoxime 18-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 224-228 28806470-1 2017 BACKGROUND: Acetylcholinesterase inhibitors, such as neostigmine, have traditionally been used for reversal of non-depolarizing neuromuscular blocking agents. Neostigmine 53-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 28465191-10 2017 The presented results might be useful in routine clinical practice where the monitoring of blood AChE and plasma BChE activity is crucial for prognosis and diagnosis of organophosphate poisoning, in occupational medicine and in relevant mass casualty scenarios. Organophosphates 169-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 28777299-5 2017 The collagen-tailed A12 acetylcholinesterase is concentrated in the synaptic cleft of NMJs and NEJs, were it curtails the postsynaptic response by ultrafast ACh hydrolysis. Acetylcholine 157-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 28777299-13 2017 A12-AChE being virtually absent in CNS, G4-AChE is the most abundant form, whose function appears to modulate the "volume" transmission, keeping ACh concentration within limits in time and space. Acetylcholine 4-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-47 27990564-4 2017 Inhibition by classic protonable amine and quaternary reversible inhibitors (ethopropazine, donepezil, tacrine, edrophonium, BW284c51, propidium) shows that DjChE is far less sensitive to these inhibitors than human AChE, suggesting discrete differences in active center and peripheral site recognition and structures. Propidium 135-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 216-220 28699213-7 2017 A kinetic study revealed them to be mixed-type inhibitors, binding with both the CAS and PAS sites of AChE. Protactinium 89-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 28544359-3 2017 These amides and thiazolidine-4-ones showed good inhibitory action against butyrylcholinesterase (BChE), acetylcholinesterase (AChE), and human carbonic anhydrase isoforms. Amides 6-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 28544359-3 2017 These amides and thiazolidine-4-ones showed good inhibitory action against butyrylcholinesterase (BChE), acetylcholinesterase (AChE), and human carbonic anhydrase isoforms. Amides 6-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 28544359-3 2017 These amides and thiazolidine-4-ones showed good inhibitory action against butyrylcholinesterase (BChE), acetylcholinesterase (AChE), and human carbonic anhydrase isoforms. thiazolidine-4-ones 17-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 28544359-3 2017 These amides and thiazolidine-4-ones showed good inhibitory action against butyrylcholinesterase (BChE), acetylcholinesterase (AChE), and human carbonic anhydrase isoforms. thiazolidine-4-ones 17-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 28544359-8 2017 Additionally, Tacrine inhibited AChE and BChE, showing Ki values of 397.03 +- 31.66 and 210.21 +- 15.98 nM, respectively. Tacrine 14-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 28542985-1 2017 Organophosphorus agents (OPs) irreversibly inhibit acetylcholinesterase (AChE) causing a major cholinergic syndrome. organophosphorus agents 0-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 28646405-0 2017 Revealing the importance of linkers in K-series oxime reactivators for tabun-inhibited AChE using quantum chemical, docking and SMD studies. Oximes 48-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 28646405-1 2017 Inhibition of acetylcholinesterase (AChE) with organophosphorus compounds has a detrimental effect on human life. organophosphorus 47-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 28646405-1 2017 Inhibition of acetylcholinesterase (AChE) with organophosphorus compounds has a detrimental effect on human life. organophosphorus 47-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 28646405-2 2017 Oxime K203 seems to be one of the promising reactivators for tabun-inhibited AChE than (K027, K127, and K628). oxime k203 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 28646405-6 2017 Such orientation of K203 experiences favorable interaction with the surrounding residues of catalytic anionic site (CAS) and peripheral anionic site (PAS) of tabun-inhibited AChE. cas 116-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 28646405-6 2017 Such orientation of K203 experiences favorable interaction with the surrounding residues of catalytic anionic site (CAS) and peripheral anionic site (PAS) of tabun-inhibited AChE. Aminosalicylic Acid 150-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 28791702-3 2017 Clinical manifestations of an acute exposure of humans to OP insecticides include a well-defined cholinergic crisis that develops as a result of the irreversible inhibition of acetylcholinesterase (AChE), the enzyme that hydrolyzes the neurotransmitter acetylcholine (ACh). Acetylcholine 176-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-202 28791702-3 2017 Clinical manifestations of an acute exposure of humans to OP insecticides include a well-defined cholinergic crisis that develops as a result of the irreversible inhibition of acetylcholinesterase (AChE), the enzyme that hydrolyzes the neurotransmitter acetylcholine (ACh). Acetylcholine 198-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-196 28542985-1 2017 Organophosphorus agents (OPs) irreversibly inhibit acetylcholinesterase (AChE) causing a major cholinergic syndrome. organophosphorus agents 0-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 28542985-1 2017 Organophosphorus agents (OPs) irreversibly inhibit acetylcholinesterase (AChE) causing a major cholinergic syndrome. OPS 25-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 28542985-1 2017 Organophosphorus agents (OPs) irreversibly inhibit acetylcholinesterase (AChE) causing a major cholinergic syndrome. OPS 25-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 28542985-6 2017 Oximes poorly reactivate AChE inhibited by phosphoramidates. Oximes 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 28411556-7 2017 In addition, H2O2, (100-1000microM) reduced the total AChE content and modified its isoform profile (mainly 50-, 70-, and 132-kDa) H2O2 from 100microM to 1000microM induced cytochrome c release confirming cell death by apoptosis. Hydrogen Peroxide 13-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 28687725-7 2017 CONCLUSIONS In conclusion, our study revealed a novel class of chalcone derivatives as a selective inhibitor of AChE with considerably action against beta-secretase and Abeta aggregation. Chalcone 63-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 28458136-3 2017 Both kinetic analysis of AChE inhibition and molecular modeling study suggested that T-22 interacted with both the catalytic active site and peripheral anionic site of AChE. t-22 85-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 28458136-3 2017 Both kinetic analysis of AChE inhibition and molecular modeling study suggested that T-22 interacted with both the catalytic active site and peripheral anionic site of AChE. t-22 85-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-172 28607150-1 2017 Acetylcholinesterase (AChE) hydrolyzes acetylcholine to terminate cholinergic transmission in neurons. Acetylcholine 39-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 28607150-1 2017 Acetylcholinesterase (AChE) hydrolyzes acetylcholine to terminate cholinergic transmission in neurons. Acetylcholine 39-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 28607150-3 2017 For instance, in bone, AChE exists as a proline-rich membrane anchor (PRiMA)-linked globular form in osteoblasts, in which it is proposed to play a noncholinergic role in differentiation. Proline 40-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 28607150-10 2017 Moreover, deletion of the Runx2-binding site in the ACHE promoter reduced its activity during osteoblastic differentiation, and addition of 5-azacytidine and trichostatin A to differentiating osteoblasts affected AChE expression, suggesting epigenetic regulation of the ACHE gene. Azacitidine 140-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-217 28607150-10 2017 Moreover, deletion of the Runx2-binding site in the ACHE promoter reduced its activity during osteoblastic differentiation, and addition of 5-azacytidine and trichostatin A to differentiating osteoblasts affected AChE expression, suggesting epigenetic regulation of the ACHE gene. trichostatin A 158-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 28607150-10 2017 Moreover, deletion of the Runx2-binding site in the ACHE promoter reduced its activity during osteoblastic differentiation, and addition of 5-azacytidine and trichostatin A to differentiating osteoblasts affected AChE expression, suggesting epigenetic regulation of the ACHE gene. trichostatin A 158-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-217 28607150-10 2017 Moreover, deletion of the Runx2-binding site in the ACHE promoter reduced its activity during osteoblastic differentiation, and addition of 5-azacytidine and trichostatin A to differentiating osteoblasts affected AChE expression, suggesting epigenetic regulation of the ACHE gene. trichostatin A 158-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 270-274 28788095-1 2017 Tacrine (THA), the first clinically effective acetylcholinesterase (AChE) inhibitor and the first approved drug for the treatment of Alzheimer"s disease (AD), was withdrawn from the market due to its side effects, particularly its hepatotoxicity. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 28788095-1 2017 Tacrine (THA), the first clinically effective acetylcholinesterase (AChE) inhibitor and the first approved drug for the treatment of Alzheimer"s disease (AD), was withdrawn from the market due to its side effects, particularly its hepatotoxicity. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 28788095-1 2017 Tacrine (THA), the first clinically effective acetylcholinesterase (AChE) inhibitor and the first approved drug for the treatment of Alzheimer"s disease (AD), was withdrawn from the market due to its side effects, particularly its hepatotoxicity. Tacrine 9-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 28788095-3 2017 One such compound, namely 7-methoxytacrine (7-MEOTA), exhibits an intriguing profile, having suppressed hepatotoxicity and concomitantly retaining AChE inhibition properties. 7-methoxytacrine 26-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 28788095-3 2017 One such compound, namely 7-methoxytacrine (7-MEOTA), exhibits an intriguing profile, having suppressed hepatotoxicity and concomitantly retaining AChE inhibition properties. 7-methoxytacrine 44-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 28788095-4 2017 Another interesting class of AChE inhibitors represents Huprines, designed by merging two fragments of the known AChE inhibitors-THA and (-)-huperzine A. huprines 56-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 28788095-4 2017 Another interesting class of AChE inhibitors represents Huprines, designed by merging two fragments of the known AChE inhibitors-THA and (-)-huperzine A. huprines 56-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 28788095-4 2017 Another interesting class of AChE inhibitors represents Huprines, designed by merging two fragments of the known AChE inhibitors-THA and (-)-huperzine A. Tacrine 129-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 28788095-4 2017 Another interesting class of AChE inhibitors represents Huprines, designed by merging two fragments of the known AChE inhibitors-THA and (-)-huperzine A. Tacrine 129-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 28788095-4 2017 Another interesting class of AChE inhibitors represents Huprines, designed by merging two fragments of the known AChE inhibitors-THA and (-)-huperzine A. huperzine A 141-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 28788095-4 2017 Another interesting class of AChE inhibitors represents Huprines, designed by merging two fragments of the known AChE inhibitors-THA and (-)-huperzine A. huperzine A 141-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 28933746-1 2017 DL0410, containing biphenyl and piperidine skeletons, was identified as an acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitor through high-throughput screening assays, and further studies affirmed its efficacy and safety for Alzheimer"s disease treatment. DL0410 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 28933746-1 2017 DL0410, containing biphenyl and piperidine skeletons, was identified as an acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitor through high-throughput screening assays, and further studies affirmed its efficacy and safety for Alzheimer"s disease treatment. DL0410 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 28933746-2 2017 In our study, a series of novel DL0410 derivatives were evaluated for inhibitory activities towards AChE and BuChE. DL0410 32-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 28933746-10 2017 These studies provide better insight into the inhibitory behaviors of DL0410 derivatives, which is beneficial for rational design of AChE and BuChE inhibitors in the future. DL0410 70-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 28737687-0 2017 New Cinchona Oximes Evaluated as Reactivators of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Organophosphorus Compounds. cinchona oximes 4-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 28737687-1 2017 For the last six decades, researchers have been focused on finding efficient reactivators of organophosphorus compound (OP)-inhibited acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). organophosphorus 93-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 28737687-1 2017 For the last six decades, researchers have been focused on finding efficient reactivators of organophosphorus compound (OP)-inhibited acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). organophosphorus 93-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-160 28737687-3 2017 Three Cinchona oximes (C1, C2, and C3), derivatives of the 9-oxocinchonidine, were synthesized and investigated in reactivation of various OP-inhibited AChE and BChE. cinchona oximes 6-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 28724799-3 2017 The aim of this study was to assess the effects of galantamine, a centrally acting acetylcholinesterase inhibitor with antiinflammatory properties, on markers of inflammation implicated in insulin resistance and cardiovascular risk, and other metabolic and cardiovascular indices in subjects with MetS. Galantamine 51-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 28552337-0 2017 One-pot microwave assisted stereoselective synthesis of novel dihydro-2"H-spiro[indene-2,1"-pyrrolo-[3,4-c]pyrrole]-tetraones and evaluation of their antimycobacterial activity and inhibition of AChE. dihydro-2"h-spiro[indene-2,1"-pyrrolo-[3,4-c]pyrrole]-tetraones 62-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 28915661-0 2017 Small molecular floribundiquinone B derived from medicinal plants inhibits acetylcholinesterase activity. Floribundiquinone A 16-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 28915661-5 2017 In this study, instead of using the synthetic compounds, we used those extracted from plants to investigate the interaction between floribundiquinone B (FB) and AChE by means of both the experimental approach such as fluorescence spectra, ultraviolet-visible (UV-vis) absorption spectrometry, circular dichroism (CD) and the theoretical approaches such as molecular docking. Floribundiquinone A 132-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-165 28411556-0 2017 Hydrogen peroxide modifies both activity and isoforms of acetylcholinesterase in human neuroblastoma SH-SY5Y cells. Hydrogen Peroxide 0-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 28411556-1 2017 The involvement of cholinergic system and the reactive oxygen species (ROS) in the pathogenesis of some degenerative diseases has been widely reported; however, the specific impact of hydrogen peroxide (H2O2) on the acetylcholinesterase (AChE) activity as well as AChE isoform levels has not been clearly established. Hydrogen Peroxide 184-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 216-236 28411556-1 2017 The involvement of cholinergic system and the reactive oxygen species (ROS) in the pathogenesis of some degenerative diseases has been widely reported; however, the specific impact of hydrogen peroxide (H2O2) on the acetylcholinesterase (AChE) activity as well as AChE isoform levels has not been clearly established. Hydrogen Peroxide 184-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 238-242 28411556-1 2017 The involvement of cholinergic system and the reactive oxygen species (ROS) in the pathogenesis of some degenerative diseases has been widely reported; however, the specific impact of hydrogen peroxide (H2O2) on the acetylcholinesterase (AChE) activity as well as AChE isoform levels has not been clearly established. Hydrogen Peroxide 184-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 264-268 28411556-1 2017 The involvement of cholinergic system and the reactive oxygen species (ROS) in the pathogenesis of some degenerative diseases has been widely reported; however, the specific impact of hydrogen peroxide (H2O2) on the acetylcholinesterase (AChE) activity as well as AChE isoform levels has not been clearly established. Hydrogen Peroxide 203-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 216-236 28411556-1 2017 The involvement of cholinergic system and the reactive oxygen species (ROS) in the pathogenesis of some degenerative diseases has been widely reported; however, the specific impact of hydrogen peroxide (H2O2) on the acetylcholinesterase (AChE) activity as well as AChE isoform levels has not been clearly established. Hydrogen Peroxide 203-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 238-242 28411556-1 2017 The involvement of cholinergic system and the reactive oxygen species (ROS) in the pathogenesis of some degenerative diseases has been widely reported; however, the specific impact of hydrogen peroxide (H2O2) on the acetylcholinesterase (AChE) activity as well as AChE isoform levels has not been clearly established. Hydrogen Peroxide 203-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 264-268 28411556-4 2017 AChE activity was strongly increased from 1microM to 1000microM of H2O2. Hydrogen Peroxide 67-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 27900576-3 2017 Although both galantamine and huperzine shared a similar time course profile for acetylcholinesterase inhibition, huperzine was 88 times more potent than galantamine. Galantamine 14-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 28621747-3 2017 Among these compounds, hybrid K1383, bearing two methylene tether between two basic scaffolds, was found to be very potent hAChE inhibitor (IC50 = 1.63 nM). k1383 30-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-128 28621747-6 2017 Kinetic studies performed on hAChE with the most active compound in the study, K1383, pointed out to a mixed, non-competitive enzyme inhibition. k1383 79-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-34 27836591-3 2017 Moreover, comparison of NiCo2S4 materials from different experiment conditions as biosensors was investigated by electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV), and the best one that was reticulated hollow spheres assembled from rod-like structures NiCo2S4 has been successfully employed as a matrix of AChE immobilization for the special structure, superior conductivity and rich reaction active sites. nico2s4 24-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 342-346 28404526-2 2017 Both S- and R-DEPP are poor inhibitors of eel AChE (IC50 150muM), consistent with a large, nondiscriminatory binding interaction in the active site of this enzyme. s- and r-depp 5-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 28404526-10 2017 Since BChE has a more accommodating acyl pocket than AChE, the similar behaviors of both enzymes toward S-DEPP is notable and is likely a reflection of the weakened potency of DEPP relative to chemical warfare agents. depp 176-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 28416102-3 2017 The di-n-butyl phosphate series consistently displayed selective inhibition of BChE over AChE. di-n-butylphosphoric acid 4-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 28454848-2 2017 Among them, compound 11b displayed potent acetylcholinesterase (AChE) inhibition (IC50=187nM) and the highest BuChE/AChE selectivity (66.3). 11b 21-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 28454848-2 2017 Among them, compound 11b displayed potent acetylcholinesterase (AChE) inhibition (IC50=187nM) and the highest BuChE/AChE selectivity (66.3). 11b 21-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 28454848-2 2017 Among them, compound 11b displayed potent acetylcholinesterase (AChE) inhibition (IC50=187nM) and the highest BuChE/AChE selectivity (66.3). 11b 21-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 28487125-4 2017 Both kinetic analysis of AChE inhibition and molecular modeling study suggested that TM-33 binds simultaneously to the catalytic active site and peripheral anionic site of AChE. tm-33 85-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 28487125-4 2017 Both kinetic analysis of AChE inhibition and molecular modeling study suggested that TM-33 binds simultaneously to the catalytic active site and peripheral anionic site of AChE. tm-33 85-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-176 28492309-8 2017 Specifically, the fullerene core covered the enzyme gorge as a lid through pi-pi stacking with Tyr72 and Trp286 in the PAS, while the hydrophobic ligands on the fullerene surface inserted into the AChE active site to provide further stability for the complexes. Fullerenes 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-201 28492309-8 2017 Specifically, the fullerene core covered the enzyme gorge as a lid through pi-pi stacking with Tyr72 and Trp286 in the PAS, while the hydrophobic ligands on the fullerene surface inserted into the AChE active site to provide further stability for the complexes. Aminosalicylic Acid 119-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-201 28492309-8 2017 Specifically, the fullerene core covered the enzyme gorge as a lid through pi-pi stacking with Tyr72 and Trp286 in the PAS, while the hydrophobic ligands on the fullerene surface inserted into the AChE active site to provide further stability for the complexes. Fullerenes 161-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-201 28433681-9 2017 The thioureas showed to have different SAR when inhibiting AChE1 and hAChE, respectively, enabling an investigation of structure-selectivity relationships. Thiourea 4-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-74 29201079-0 2017 Docking Studies, Synthesis, and In-vitro Evaluation of Novel Oximes Based on Nitrones as Reactivators of Inhibited Acetylcholinesterase. Oximes 61-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 29201079-7 2017 Then, more effective reactivatorsoximes in terms of binding energy and orientation within the active site were synthesized and evaluated in-vitro on human AChE (hAChE) inhibited by paraoxon and compared to standard hAChE reactivators (2-PAM and obidoxime). Paraoxon 181-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 29201079-7 2017 Then, more effective reactivatorsoximes in terms of binding energy and orientation within the active site were synthesized and evaluated in-vitro on human AChE (hAChE) inhibited by paraoxon and compared to standard hAChE reactivators (2-PAM and obidoxime). Paraoxon 181-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-166 27900576-1 2017 Galantamine hydrobromide and (-)huperzine A, centrally active reversible acetylcholinesterase inhibitors, are potentially superior to the current standard, pyridostigmine bromide, as a pretreatment for organophosphorus chemical warfare nerve agent intoxication. Galantamine 0-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 27900576-1 2017 Galantamine hydrobromide and (-)huperzine A, centrally active reversible acetylcholinesterase inhibitors, are potentially superior to the current standard, pyridostigmine bromide, as a pretreatment for organophosphorus chemical warfare nerve agent intoxication. huperzine A 29-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 27900576-3 2017 Although both galantamine and huperzine shared a similar time course profile for acetylcholinesterase inhibition, huperzine was 88 times more potent than galantamine. huperzine A 30-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 27900576-4 2017 The dose for 50% acetylcholinesterase inhibition (ID50) was 4.1 ug/kg for huperzine, 362 ug/kg for galantamine, and 30.9 ug/kg for pyridostigmine. huperzine A 74-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 27900576-4 2017 The dose for 50% acetylcholinesterase inhibition (ID50) was 4.1 ug/kg for huperzine, 362 ug/kg for galantamine, and 30.9 ug/kg for pyridostigmine. Galantamine 99-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 27900576-4 2017 The dose for 50% acetylcholinesterase inhibition (ID50) was 4.1 ug/kg for huperzine, 362 ug/kg for galantamine, and 30.9 ug/kg for pyridostigmine. Pyridostigmine Bromide 131-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 27900576-6 2017 Huperzine and pyridostigmine were devoid of behavioral toxicity, whereas galantamine was behaviorally toxic at doses producing peak acetylcholinesterase inhibition of about 50% and higher. Galantamine 73-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-152 27900576-11 2017 The degree of acetylcholinesterase inhibition was lower for pyridostigmine, but rates of recovery of acetylcholinesterase activity following soman challenge were comparable for all drug pretreatments. Pyridostigmine Bromide 60-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 27900576-12 2017 Huperzine may be the more promising centrally active reversible acetylcholinesterase inhibitor due to its greater potency and superior safety profile. huperzine A 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 28427041-0 2017 The efficacy of donepezil administration on acetylcholinesterase activity and altered redox homeostasis in Alzheimer"s disease. Donepezil 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 28427041-6 2017 The AChE activity was significantly higher both in donepezil treated and untreated groups when compared with the control group. Donepezil 51-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 28478328-1 2017 The present study describes the synthesis, pharmacological evaluation (BChE/AChE inhibition, Abeta antiaggregation, and neuroprotective effects), and molecular modeling studies of novel 2-[4-(4-substitutedpiperazin-1-yl)phenyl]benzimidazole derivatives. 2-[4-(4-substitutedpiperazin-1-yl)phenyl]benzimidazole 186-240 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 28495556-1 2017 Pursuing the strategy of developing potent AChE inhibitors, we attempted to carry out the N1-substitution of 2,3-dihydroquinazolin-4(1H)-one core. 2,3-dihydroquinazolin-4 109-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 28495556-1 2017 Pursuing the strategy of developing potent AChE inhibitors, we attempted to carry out the N1-substitution of 2,3-dihydroquinazolin-4(1H)-one core. Hydrogen 133-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 28432980-2 2017 Human acetylcholinesterase (hAChE), an important enzyme in neuronal signaling, is responsible for the degradation of acetylcholine which in turn prevents the post synaptic signal transmissions. Acetylcholine 6-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-33 28632395-4 2017 Replacement by [1,8]-naphthyridine or thieno[3,2-e]pyridine systems resulted in decreased, although still potent, acetylcholinesterase or BACE-1 inhibitory activities, which are more balanced relative to their Abeta42 and tau antiaggregating and antioxidant activities. [1,8]-naphthyridine 15-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 28632395-4 2017 Replacement by [1,8]-naphthyridine or thieno[3,2-e]pyridine systems resulted in decreased, although still potent, acetylcholinesterase or BACE-1 inhibitory activities, which are more balanced relative to their Abeta42 and tau antiaggregating and antioxidant activities. thieno[3,2-e]pyridine 38-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 28632402-2 2017 We propose 3-(benzyloxy)-1-(5-[18F]fluoropentyl)-5-nitro-1H-indazole, [18F]-IND1, structurally related to the AChE-inhibitor CP126,998, as a new positron emission tomography-radiotracer. 3-(benzyloxy)-1-(5-fluoropentyl)-5-nitro-1H-indazole 11-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 28632402-2 2017 We propose 3-(benzyloxy)-1-(5-[18F]fluoropentyl)-5-nitro-1H-indazole, [18F]-IND1, structurally related to the AChE-inhibitor CP126,998, as a new positron emission tomography-radiotracer. cp126 125-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 28868119-2 2017 MATERIALS AND METHODS: Different 7-hydroxycoumarin derivatives were synthesized via Pechmann or Knoevenagel condensation and conjugated to different benzoheterocycle (8-hydroxyquinoline, 2-mercaptobenzoxazole or 2-mercaptobenzimidazole) using dibromoalkanes 3a-m: Final compounds were evaluated against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) by Ellman"s method. 7-hydroxycoumarin 33-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 303-323 28868119-2 2017 MATERIALS AND METHODS: Different 7-hydroxycoumarin derivatives were synthesized via Pechmann or Knoevenagel condensation and conjugated to different benzoheterocycle (8-hydroxyquinoline, 2-mercaptobenzoxazole or 2-mercaptobenzimidazole) using dibromoalkanes 3a-m: Final compounds were evaluated against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) by Ellman"s method. 7-hydroxycoumarin 33-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 325-329 28868119-5 2017 Compound 3b containing the quinoline group showed the best activity with an IC50 value of 8.80 muM against AChE. quinoline 27-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 27410776-0 2017 Identification of molecular descriptors for design of novel Isoalloxazine derivatives as potential Acetylcholinesterase inhibitors against Alzheimer"s disease. isoalloxazine 60-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 27410776-2 2017 Since Acetylcholinesterase (AChE) cleaves ACh, inhibitors of AChE are very much sought after for AD treatment. Acetylcholine 28-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-26 27410776-2 2017 Since Acetylcholinesterase (AChE) cleaves ACh, inhibitors of AChE are very much sought after for AD treatment. Acetylcholine 28-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 27410776-4 2017 Isoalloxazine derivatives have proved to be promising (AChE) inhibitors. isoalloxazine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 27410776-10 2017 Isoalloxazine derivatives were docked against human AChE, which revealed critical residues implicated in hydrogen bonds as well as hydrophobic interactions. isoalloxazine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 27410776-10 2017 Isoalloxazine derivatives were docked against human AChE, which revealed critical residues implicated in hydrogen bonds as well as hydrophobic interactions. Hydrogen 105-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 27410776-12 2017 The present study may be useful in the design of more potent Isoalloxazine derivatives as AChE inhibitors. isoalloxazine 61-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 28251653-3 2017 CASE SUMMARY: A 77-year-old women experienced probable acetylcholinesterase inhibitor-induced rhinorrhea and subsequently self-medicated with diphenhydramine which lead to worsening cognitive function. Diphenhydramine 142-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 27748125-0 2017 Acetylcholinesterase inhibitory activity of pyrrolizidine alkaloids from Echium confusum Coincy. Pyrrolizidine Alkaloids 44-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 28610432-0 2017 QSAR model for prediction of the therapeutic potency of N-benzylpiperidine derivatives as AChE inhibitors. 1-benzylpiperidine 56-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 28610432-1 2017 A new family of AChE inhibitors, N-benzylpiperidines, showed exceptional efficacy in vitro and in vivo, minimal side effects and high selectivity for acetylcholinesterase (AChE). 1-benzylpiperidine 33-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 28610432-1 2017 A new family of AChE inhibitors, N-benzylpiperidines, showed exceptional efficacy in vitro and in vivo, minimal side effects and high selectivity for acetylcholinesterase (AChE). 1-benzylpiperidine 33-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 28610432-1 2017 A new family of AChE inhibitors, N-benzylpiperidines, showed exceptional efficacy in vitro and in vivo, minimal side effects and high selectivity for acetylcholinesterase (AChE). 1-benzylpiperidine 33-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-176 28427893-0 2017 Study of acetylcholinesterase activity and apoptosis in SH-SY5Y cells and mice exposed to ethanol. Ethanol 90-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 28427893-6 2017 AChE activity was quantified by spectrophotometry and apoptosis by flow cytometer in SH-SY5Y cells exposed to ethanol. Ethanol 110-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 28427893-12 2017 In conclusion, AChE activity and apoptosis were induced in SH-SY5Y cells and mice treated with ethanol, which may indicate that increased AChE may related to apoptosis induced by ethanol. Ethanol 95-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 28427893-12 2017 In conclusion, AChE activity and apoptosis were induced in SH-SY5Y cells and mice treated with ethanol, which may indicate that increased AChE may related to apoptosis induced by ethanol. Ethanol 179-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 28286284-7 2017 Ketamine was shown to be capable of increasing the activity of acetylcholinesterase (AChE) in the brain structures. Ketamine 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 28286284-7 2017 Ketamine was shown to be capable of increasing the activity of acetylcholinesterase (AChE) in the brain structures. Ketamine 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 28294544-8 2017 A group of inhibitors were identified from this study, including known (e.g. physostigmine and neostigmine bromide) and potential novel AChE inhibitors (e.g. chelerythrine chloride and cilostazol). chelerythrine 158-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 28629119-2 2017 This study focused on the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of adamantyl-based ester derivatives with various substituents on the phenyl ring using Ellman"s colorimetric method. adamantyl-based ester 112-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 28629119-3 2017 Compound 2e with a 2,4-dichloro electron-withdrawing substituent on the phenyl ring exhibited the strongest inhibition effect against AChE, with an IC50 value of 77.15 microM. 2,4-dichloro 19-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 28629119-4 2017 Overall, the adamantyl-based ester with the mono-substituent at position 3 of the phenyl ring exhibited good AChE inhibition effects with an ascending order for the substituents: Cl < NO2 < CH3 < OCH3. adamantyl-based ester 13-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 28629119-4 2017 Overall, the adamantyl-based ester with the mono-substituent at position 3 of the phenyl ring exhibited good AChE inhibition effects with an ascending order for the substituents: Cl < NO2 < CH3 < OCH3. Nitrogen Dioxide 187-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 28629119-5 2017 Furthermore, compounds with electron-withdrawing groups (Cl and NO2) substituted at position 3 on their phenyl rings demonstrated stronger AChE inhibition effects, in comparison to their respective positional isomers. Nitrogen Dioxide 64-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 28629119-7 2017 Molecular docking analyses were conducted for potential AChE and BChE inhibitors, and the results demonstrated that the peripheral anionic sites of target proteins were predominant binding sites for these compounds through hydrogen bonds and halogen interactions instead of hydrophobic interactions in the catalytic active site. Hydrogen 223-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 28629119-7 2017 Molecular docking analyses were conducted for potential AChE and BChE inhibitors, and the results demonstrated that the peripheral anionic sites of target proteins were predominant binding sites for these compounds through hydrogen bonds and halogen interactions instead of hydrophobic interactions in the catalytic active site. Halogens 242-249 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 28302311-0 2017 The first synthesis of 4-phenylbutenone derivative bromophenols including natural products and their inhibition profiles for carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase enzymes. benzylideneacetone 23-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 28302311-0 2017 The first synthesis of 4-phenylbutenone derivative bromophenols including natural products and their inhibition profiles for carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase enzymes. bromophenols 51-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 28104598-1 2017 We report a case of Pisa syndrome (PS) due to the acetylcholinesterase inhibitor donepezil which may have been precipitated by pharmacokinetic interactions with commonly used medications. Donepezil 81-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 28294544-1 2017 Acetylcholinesterase (AChE) is an enzyme responsible for metabolism of acetylcholine, a neurotransmitter associated with muscle movement, cognition, and other neurobiological processes. Acetylcholine 71-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 28294544-1 2017 Acetylcholinesterase (AChE) is an enzyme responsible for metabolism of acetylcholine, a neurotransmitter associated with muscle movement, cognition, and other neurobiological processes. Acetylcholine 71-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 28518050-2 2017 Acetylcholinesterase (AChE) is a glycosylphosphatidylinositol (GPI)-linked enzyme that may serve as a marker for membrane processes occurring this ageing-associated remodelling process. Glycosylphosphatidylinositols 33-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 28518050-2 2017 Acetylcholinesterase (AChE) is a glycosylphosphatidylinositol (GPI)-linked enzyme that may serve as a marker for membrane processes occurring this ageing-associated remodelling process. Glycosylphosphatidylinositols 33-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 28518050-2 2017 Acetylcholinesterase (AChE) is a glycosylphosphatidylinositol (GPI)-linked enzyme that may serve as a marker for membrane processes occurring this ageing-associated remodelling process. Glycosylphosphatidylinositols 63-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 28518050-2 2017 Acetylcholinesterase (AChE) is a glycosylphosphatidylinositol (GPI)-linked enzyme that may serve as a marker for membrane processes occurring this ageing-associated remodelling process. Glycosylphosphatidylinositols 63-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 28299407-1 2017 Acetylcholinesterase (AChE) enzyme has been predominantly used for the detection of pesticides and metal ions. Metals 99-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 28299407-1 2017 Acetylcholinesterase (AChE) enzyme has been predominantly used for the detection of pesticides and metal ions. Metals 99-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 28299407-3 2017 Hence in this work, the amount of thiocholine produced during AChE inhibition has been estimated to detect the residual activity of AChE enzyme in-turn to enhance the efficiency of the biosensor. Thiocholine 34-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 28299407-3 2017 Hence in this work, the amount of thiocholine produced during AChE inhibition has been estimated to detect the residual activity of AChE enzyme in-turn to enhance the efficiency of the biosensor. Thiocholine 34-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 28299407-4 2017 In this context, Pt/ZnO-CeO2/AChE/Chitosan based biosensor has been developed for sensitive voltammetric quantification of thiocholine in AChE. Thiocholine 123-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 28299407-4 2017 In this context, Pt/ZnO-CeO2/AChE/Chitosan based biosensor has been developed for sensitive voltammetric quantification of thiocholine in AChE. Thiocholine 123-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 27779818-1 2017 Acetylcholinesterase is a potent enzyme that regulates neurotransmission by rapidly hydrolyzing the neurotransmitter acetylcholine in synapses of the nervous system. Acetylcholine 117-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 27779818-7 2017 Furthermore, the binding free energy between the inhibitor and hAChE for hAChE/TZ5 is significantly lower than of either hAChE/huprine or hAChE/1YL. huprine 127-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-68 27779818-7 2017 Furthermore, the binding free energy between the inhibitor and hAChE for hAChE/TZ5 is significantly lower than of either hAChE/huprine or hAChE/1YL. huprine 127-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-78 27779818-7 2017 Furthermore, the binding free energy between the inhibitor and hAChE for hAChE/TZ5 is significantly lower than of either hAChE/huprine or hAChE/1YL. huprine 127-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-78 27779818-7 2017 Furthermore, the binding free energy between the inhibitor and hAChE for hAChE/TZ5 is significantly lower than of either hAChE/huprine or hAChE/1YL. huprine 127-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-78 28294544-8 2017 A group of inhibitors were identified from this study, including known (e.g. physostigmine and neostigmine bromide) and potential novel AChE inhibitors (e.g. chelerythrine chloride and cilostazol). Cilostazol 185-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 28190243-7 2017 The acetylcholinesterase inhibitor neostigmine significantly increased amplitude of phasic activity only in bladder strips following castration, and this was prevented by testosterone replacement. Neostigmine 35-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 28190243-7 2017 The acetylcholinesterase inhibitor neostigmine significantly increased amplitude of phasic activity only in bladder strips following castration, and this was prevented by testosterone replacement. Testosterone 171-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 28208063-2 2017 We investigated the relationship between WML load assessed with the Scheltens scale, cerebral acetylcholinesterase (AChE) activity measured with [11C]N-methyl-4-piperidyl acetate PET, and neuropsychological performance in 17 patients with MCI due to AD and 18 cognitively normal older participants. N-methyl-4-piperidyl acetate 150-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 28723196-1 2017 This study addresses the need for sensitive pesticide assay by reporting a new label-free and immobilization-free homogeneous electroanalytical strategy, which combines acetylcholinesterase (AChE)-catalyzed hydrolysis product-mediated DNA conformational switch and rolling circle amplification (RCA) to detect organophosphorous and carbamate pesticides in a "signal-on" mode. organophosphorous 310-327 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-189 28723196-1 2017 This study addresses the need for sensitive pesticide assay by reporting a new label-free and immobilization-free homogeneous electroanalytical strategy, which combines acetylcholinesterase (AChE)-catalyzed hydrolysis product-mediated DNA conformational switch and rolling circle amplification (RCA) to detect organophosphorous and carbamate pesticides in a "signal-on" mode. organophosphorous 310-327 acetylcholinesterase (Cartwright blood group) Homo sapiens 191-195 28723196-1 2017 This study addresses the need for sensitive pesticide assay by reporting a new label-free and immobilization-free homogeneous electroanalytical strategy, which combines acetylcholinesterase (AChE)-catalyzed hydrolysis product-mediated DNA conformational switch and rolling circle amplification (RCA) to detect organophosphorous and carbamate pesticides in a "signal-on" mode. Carbamates 332-341 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-189 28723196-1 2017 This study addresses the need for sensitive pesticide assay by reporting a new label-free and immobilization-free homogeneous electroanalytical strategy, which combines acetylcholinesterase (AChE)-catalyzed hydrolysis product-mediated DNA conformational switch and rolling circle amplification (RCA) to detect organophosphorous and carbamate pesticides in a "signal-on" mode. Carbamates 332-341 acetylcholinesterase (Cartwright blood group) Homo sapiens 191-195 28723196-2 2017 When target pesticides were present, AChE activity was inhibited and could not trigger the following DNA conformational change and the RCA reaction, which results in numerous methylene blue (MB) molecules in a free state, generating a strong electrochemical response. Methylene Blue 175-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 28723196-2 2017 When target pesticides were present, AChE activity was inhibited and could not trigger the following DNA conformational change and the RCA reaction, which results in numerous methylene blue (MB) molecules in a free state, generating a strong electrochemical response. Methylene Blue 191-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 28406297-1 2017 In the present study, the binding free energy of some classical inhibitors (DMT, DNP, GNT, HUP, THA) with acetylcholinesterase (AChE) is calculated by means of the free energy perturbation (FEP) method based on hybrid quantum mechanics and molecular mechanics (QM/MM) potentials. dmt 76-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 28406297-1 2017 In the present study, the binding free energy of some classical inhibitors (DMT, DNP, GNT, HUP, THA) with acetylcholinesterase (AChE) is calculated by means of the free energy perturbation (FEP) method based on hybrid quantum mechanics and molecular mechanics (QM/MM) potentials. dmt 76-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 28406297-1 2017 In the present study, the binding free energy of some classical inhibitors (DMT, DNP, GNT, HUP, THA) with acetylcholinesterase (AChE) is calculated by means of the free energy perturbation (FEP) method based on hybrid quantum mechanics and molecular mechanics (QM/MM) potentials. 2,4-Dinitrophenol 81-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 28406297-1 2017 In the present study, the binding free energy of some classical inhibitors (DMT, DNP, GNT, HUP, THA) with acetylcholinesterase (AChE) is calculated by means of the free energy perturbation (FEP) method based on hybrid quantum mechanics and molecular mechanics (QM/MM) potentials. 2,4-Dinitrophenol 81-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 28406297-6 2017 Although several hydrogen bonds between ligands and AChE do appear, no significant values of BIEs have been recorded. Hydrogen 17-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 28406297-7 2017 This behavior can be accounted for by the special features of AChE, such as the presence of several subsites of different natures in the gorge or the existence of several water molecules that act as bridges in the electrostatic interactions. Water 171-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 28458525-0 2017 Rivastigmine: the advantages of dual inhibition of acetylcholinesterase and butyrylcholinesterase and its role in subcortical vascular dementia and Parkinson"s disease dementia. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 28458525-2 2017 Unlike donepezil and galantamine that selectively inhibit acetylcholinesterase (AChE; EC 3.1.1.7), rivastigmine is a unique cholinesterase inhibitor with both AChE and butyrylcholinesterase (BuChE; EC 3.1.1.8) inhibitory activity. Galantamine 21-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 28458525-2 2017 Unlike donepezil and galantamine that selectively inhibit acetylcholinesterase (AChE; EC 3.1.1.7), rivastigmine is a unique cholinesterase inhibitor with both AChE and butyrylcholinesterase (BuChE; EC 3.1.1.8) inhibitory activity. Galantamine 21-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 28458525-2 2017 Unlike donepezil and galantamine that selectively inhibit acetylcholinesterase (AChE; EC 3.1.1.7), rivastigmine is a unique cholinesterase inhibitor with both AChE and butyrylcholinesterase (BuChE; EC 3.1.1.8) inhibitory activity. Rivastigmine 99-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 28458525-5 2017 Additionally, we review the evidence supporting the use of dual AChE-BuChE inhibitory activity of rivastigmine as a therapeutic strategy in the treatment of neurological disorders, with a focus on the role of rivastigmine in subcortical dementias such as vascular dementia (VaD) and PDD. Rivastigmine 98-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 28458525-7 2017 The available evidence from the literature suggests that the dual inhibition of AChE and BuChE may afford additional therapeutic potential of rivastigmine in subcortical dementias (subcortical VaD and PDD) with benefits on cognition and behavioral symptoms. Rivastigmine 142-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 28106328-1 2017 Acetylcholinesterase (AChE), an enzyme of the serine hydrolase superfamily, is a mediator of signal transmission at cholinergic synapses by catalyzing acetylcholine cleavage into acetate and choline. Acetylcholine 151-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 28106328-1 2017 Acetylcholinesterase (AChE), an enzyme of the serine hydrolase superfamily, is a mediator of signal transmission at cholinergic synapses by catalyzing acetylcholine cleavage into acetate and choline. Acetylcholine 151-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 28106328-1 2017 Acetylcholinesterase (AChE), an enzyme of the serine hydrolase superfamily, is a mediator of signal transmission at cholinergic synapses by catalyzing acetylcholine cleavage into acetate and choline. Acetates 179-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 28106328-1 2017 Acetylcholinesterase (AChE), an enzyme of the serine hydrolase superfamily, is a mediator of signal transmission at cholinergic synapses by catalyzing acetylcholine cleavage into acetate and choline. Acetates 179-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 28106328-1 2017 Acetylcholinesterase (AChE), an enzyme of the serine hydrolase superfamily, is a mediator of signal transmission at cholinergic synapses by catalyzing acetylcholine cleavage into acetate and choline. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 28106328-5 2017 QM/MM simulations of VX-inhibited AChE reactivation by pralidoxime (2-PAM), a classical reactivator, were performed. pralidoxime 55-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 28106328-5 2017 QM/MM simulations of VX-inhibited AChE reactivation by pralidoxime (2-PAM), a classical reactivator, were performed. pralidoxime 68-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 28169488-0 2017 Acetylcholinesterase-capped Mesoporous Silica Nanoparticles Controlled by the Presence of Inhibitors. Silicon Dioxide 39-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 28169488-1 2017 Two different acetylcholinesterase (AChE)-capped mesoporous silica nanoparticles (MSNs), S1-AChE and S2-AChE, were prepared and characterized. Silicon Dioxide 60-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 28169488-1 2017 Two different acetylcholinesterase (AChE)-capped mesoporous silica nanoparticles (MSNs), S1-AChE and S2-AChE, were prepared and characterized. Silicon Dioxide 60-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 28169488-4 2017 Both materials were able to release rhodamine B in the presence of diisopropylfluorophosphate (DFP) or neostigmine in a concentration-dependent manner via the competitive displacement of AChE through DFP and neostigmine coordination with the AChE"s active sites. rhodamine B 36-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 28169488-4 2017 Both materials were able to release rhodamine B in the presence of diisopropylfluorophosphate (DFP) or neostigmine in a concentration-dependent manner via the competitive displacement of AChE through DFP and neostigmine coordination with the AChE"s active sites. rhodamine B 36-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 242-246 28169488-4 2017 Both materials were able to release rhodamine B in the presence of diisopropylfluorophosphate (DFP) or neostigmine in a concentration-dependent manner via the competitive displacement of AChE through DFP and neostigmine coordination with the AChE"s active sites. Isoflurophate 67-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 28169488-4 2017 Both materials were able to release rhodamine B in the presence of diisopropylfluorophosphate (DFP) or neostigmine in a concentration-dependent manner via the competitive displacement of AChE through DFP and neostigmine coordination with the AChE"s active sites. Isoflurophate 67-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 242-246 28169488-4 2017 Both materials were able to release rhodamine B in the presence of diisopropylfluorophosphate (DFP) or neostigmine in a concentration-dependent manner via the competitive displacement of AChE through DFP and neostigmine coordination with the AChE"s active sites. Isoflurophate 95-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 28169488-4 2017 Both materials were able to release rhodamine B in the presence of diisopropylfluorophosphate (DFP) or neostigmine in a concentration-dependent manner via the competitive displacement of AChE through DFP and neostigmine coordination with the AChE"s active sites. Isoflurophate 95-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 242-246 28169488-4 2017 Both materials were able to release rhodamine B in the presence of diisopropylfluorophosphate (DFP) or neostigmine in a concentration-dependent manner via the competitive displacement of AChE through DFP and neostigmine coordination with the AChE"s active sites. Neostigmine 103-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 28169488-4 2017 Both materials were able to release rhodamine B in the presence of diisopropylfluorophosphate (DFP) or neostigmine in a concentration-dependent manner via the competitive displacement of AChE through DFP and neostigmine coordination with the AChE"s active sites. Neostigmine 103-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 242-246 28169488-4 2017 Both materials were able to release rhodamine B in the presence of diisopropylfluorophosphate (DFP) or neostigmine in a concentration-dependent manner via the competitive displacement of AChE through DFP and neostigmine coordination with the AChE"s active sites. Neostigmine 208-219 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 28169488-4 2017 Both materials were able to release rhodamine B in the presence of diisopropylfluorophosphate (DFP) or neostigmine in a concentration-dependent manner via the competitive displacement of AChE through DFP and neostigmine coordination with the AChE"s active sites. Neostigmine 208-219 acetylcholinesterase (Cartwright blood group) Homo sapiens 242-246 28267984-0 2017 Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer"s disease. Pyridoxine 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 28267984-0 2017 Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer"s disease. Resveratrol 11-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 28267984-0 2017 Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer"s disease. Mannich Bases 31-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 28267984-0 2017 Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer"s disease. Metals 120-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 28008633-6 2017 DTNB and AChE/ATC (or Cys) flow towards each other where a reaction occurs to form the yellow colored 2-nitro-5-thiobenzoic acid anion (TNB2- ). Cysteine 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 28008633-6 2017 DTNB and AChE/ATC (or Cys) flow towards each other where a reaction occurs to form the yellow colored 2-nitro-5-thiobenzoic acid anion (TNB2- ). 2-nitro-5-thiobenzoic acid anion 102-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 28058724-5 2017 AChE is transported through the other inlet channel and mixes with the ATC (or Cys) as they travel up to the analysis sites. Cysteine 79-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 27967267-1 2017 INTRODUCTION: Acetylcholinesterase (AChE) is the major enzyme that hydrolyzes acetylcholine, a key neurotransmitter for synaptic transmission, into acetic acid and choline. Acetylcholine 78-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 27967267-1 2017 INTRODUCTION: Acetylcholinesterase (AChE) is the major enzyme that hydrolyzes acetylcholine, a key neurotransmitter for synaptic transmission, into acetic acid and choline. Acetylcholine 78-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 27967267-1 2017 INTRODUCTION: Acetylcholinesterase (AChE) is the major enzyme that hydrolyzes acetylcholine, a key neurotransmitter for synaptic transmission, into acetic acid and choline. Acetic Acid 148-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 27967267-1 2017 INTRODUCTION: Acetylcholinesterase (AChE) is the major enzyme that hydrolyzes acetylcholine, a key neurotransmitter for synaptic transmission, into acetic acid and choline. Acetic Acid 148-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 27967267-1 2017 INTRODUCTION: Acetylcholinesterase (AChE) is the major enzyme that hydrolyzes acetylcholine, a key neurotransmitter for synaptic transmission, into acetic acid and choline. Choline 20-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 27967267-4 2017 To combat this, AChE reactivators have to be developed to remove the offending AChE inhibitor, restoring acetylcholine levels to normal. Acetylcholine 105-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 27967267-4 2017 To combat this, AChE reactivators have to be developed to remove the offending AChE inhibitor, restoring acetylcholine levels to normal. Acetylcholine 105-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 27967267-5 2017 Areas covered: This article covers recent advances in the development of acetylcholinesterase modulators, including both inhibitors of acetylcholinesterase for the efforts in development of new chemical entities for treatment of AD, as well as re-activators for resurrection of organophosphate bound acetylcholinesterase. Organophosphates 278-293 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 27967267-8 2017 New AChE inhibitors with polypharmacology or dual inhibitory activity have also emerged as highlighted by new AChE inhibitors with dual activity at L-type calcium channels, GSK-3, BACE1 and H3, although most only show low micromolar activity, thus further research is warranted. Calcium 155-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 27967267-8 2017 New AChE inhibitors with polypharmacology or dual inhibitory activity have also emerged as highlighted by new AChE inhibitors with dual activity at L-type calcium channels, GSK-3, BACE1 and H3, although most only show low micromolar activity, thus further research is warranted. Calcium 155-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 27967267-9 2017 New small molecule reactivators of organophosphate-inhibited AChE have also been disclosed, which focused on the design of neutral ligands with improved pharmaceutical properties and blood-brain barrier (BBB) penetration. Organophosphates 35-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 28827871-2 2017 Acetylcholinesterase inhibitors, such as rivastigmine, have been studied for improving cognitive performance in these patients. Rivastigmine 41-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 30023627-0 2017 N-Methyl-beta-carbolinium Salts and an N-Methylated 8-Oxoisoguanine as Acetylcholinesterase Inhibitors from a Solitary Ascidian, Cnemidocarpa irene. methylated 8-oxoisoguanine 41-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 30023627-0 2017 N-Methyl-beta-carbolinium Salts and an N-Methylated 8-Oxoisoguanine as Acetylcholinesterase Inhibitors from a Solitary Ascidian, Cnemidocarpa irene. cnemidocarpa 129-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 30023627-4 2017 The activities of 1 and 5 were comparable to those of galantamine, a clinically used AchE inhibitor. Galantamine 54-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 28220973-2 2017 We prepared and characterized Janus Au-mesoporous silica nanoparticles functionalized with acetylcholinesterase on the Au face and with supramolecular beta-cyclodextrin:benzimidazole inclusion complexes as caps on the mesoporous silica face. Silicon Dioxide 50-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 28220973-2 2017 We prepared and characterized Janus Au-mesoporous silica nanoparticles functionalized with acetylcholinesterase on the Au face and with supramolecular beta-cyclodextrin:benzimidazole inclusion complexes as caps on the mesoporous silica face. Gold 36-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 28174098-2 2017 Recent literature has reported that human bone marrow-derived MSCs express active acetylcholinesterase (AChE) and that disruption of AChE activity by organophosphate (OP) chemicals decreases the ability of MSCs to differentiate into osteoblasts. Organophosphates 150-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 28174098-7 2017 To elucidate the possible role of AChE in MSCs signaling following OP exposure, we captured potential AChE binding partners by performing polyhistidine (His8)-tagged AChE pulldowns, followed by protein identification using liquid chromatography mass spectrometry (LC-MS). polyhistidine 138-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 28174098-7 2017 To elucidate the possible role of AChE in MSCs signaling following OP exposure, we captured potential AChE binding partners by performing polyhistidine (His8)-tagged AChE pulldowns, followed by protein identification using liquid chromatography mass spectrometry (LC-MS). polyhistidine 138-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 28338634-4 2017 In this work, an electrochemical biosensor having AChE immobilized onto MPs and stabilized through glutaraldehyde (GA) molecule was proposed for assay of the neurotoxic compounds. Glutaral 99-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 28338634-4 2017 In this work, an electrochemical biosensor having AChE immobilized onto MPs and stabilized through glutaraldehyde (GA) molecule was proposed for assay of the neurotoxic compounds. Glutaral 115-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 28338634-5 2017 The prepared nanoparticles were modified by pure AChE and they were used for the measurement anti-Alzheimer"s drug galantamine and carbamate pesticide carbofuran with limit of detection 1.5 microM and 20 nM, respectively. Carbamates 131-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 28338634-5 2017 The prepared nanoparticles were modified by pure AChE and they were used for the measurement anti-Alzheimer"s drug galantamine and carbamate pesticide carbofuran with limit of detection 1.5 microM and 20 nM, respectively. Carbofuran 151-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 28338634-8 2017 Part of this work was the elimination of reversible inhibitors represented by galantamine from the active site of AChE. Galantamine 78-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 28338634-9 2017 For this purpose, we used a lower pH to get the original activity of AChE after inhibition by galantamine. Galantamine 94-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 28338634-10 2017 We also observed decarbamylation of the AChE-carbofuran adduct. Carbofuran 45-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 28373858-3 2017 To determine if enhancing central cholinergic activity with the centrally acting acetylcholinesterase inhibitor, physostigmine would increase CBF when upright compared to the peripherally acting acetylcholinesterase inhibitor, neostigmine, or saline. Physostigmine 113-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 27342368-1 2017 An essential biological sensor for acetylcholine (ACh) detection is constructed by immobilizing enzymes, acetylcholinesterase (AChE) and choline oxidase (ChO), on the surface of iron oxide nanoparticles (Fe2O3NPs), poly(3,4-ethylenedioxythiophene) (PEDOT)-reduced graphene oxide (rGO) nanocomposite modified fluorine doped tin oxide (FTO). Acetylcholine 35-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 31294152-5 2017 Oximes are compounds that reactivate Acetylcholinesterase (AChE), a regulatory enzyme responsible for the transmission of nerve impulses, which is one of the molecular targets most vulnerable to neurotoxic agents. Oximes 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 31294152-5 2017 Oximes are compounds that reactivate Acetylcholinesterase (AChE), a regulatory enzyme responsible for the transmission of nerve impulses, which is one of the molecular targets most vulnerable to neurotoxic agents. Oximes 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 28284186-8 2017 The AChE inhibitory activity of EPHF was evaluated by Ellman method. ephf 32-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 28284186-12 2017 In addition, EPHF exhibited strong antioxidant and AChE inhibitory activity (ORAC value: 11.65 +- 2.37 muM Trolox equivalents (TE)/mg, DPPH IC50 value: 6.72 mug/mL, anti-AChE activity IC50 value: 11.72 mug/mL) compared with PHF and HF. ephf 13-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 28284186-12 2017 In addition, EPHF exhibited strong antioxidant and AChE inhibitory activity (ORAC value: 11.65 +- 2.37 muM Trolox equivalents (TE)/mg, DPPH IC50 value: 6.72 mug/mL, anti-AChE activity IC50 value: 11.72 mug/mL) compared with PHF and HF. ephf 13-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 28284186-15 2017 The contents of flavonoids especially anthocyanin in EPHF were increased significantly compared with the PHF, and EPHF exhibited strong antioxidant, AChE inhibitory activity and cytotoxicity on human tumour cells. ephf 114-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 28192982-4 2017 With the occurrence of the enzymatic reactions induced by the acetylcholinesterase (AChE) and choline oxidase (ChOx), the cathodic ECL signal from RGO-CdTe QDs was at "signal off" state due to the consumption of dissolved O2. cadmium telluride 151-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 28192982-4 2017 With the occurrence of the enzymatic reactions induced by the acetylcholinesterase (AChE) and choline oxidase (ChOx), the cathodic ECL signal from RGO-CdTe QDs was at "signal off" state due to the consumption of dissolved O2. cadmium telluride 151-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 28192982-4 2017 With the occurrence of the enzymatic reactions induced by the acetylcholinesterase (AChE) and choline oxidase (ChOx), the cathodic ECL signal from RGO-CdTe QDs was at "signal off" state due to the consumption of dissolved O2. Oxygen 222-224 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 28192982-4 2017 With the occurrence of the enzymatic reactions induced by the acetylcholinesterase (AChE) and choline oxidase (ChOx), the cathodic ECL signal from RGO-CdTe QDs was at "signal off" state due to the consumption of dissolved O2. Oxygen 222-224 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 27358236-3 2017 An interim solution could be the administration of external AChE or BChE from blood products to augment pseudocatalytic scavenging with slower but clinically approved oximes to decrease nerve agent concentrations in the body. Oximes 167-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 27358236-4 2017 We here semiquantitatively investigate the ability of obidoxime and HI-6 to decrease the inhibitory activity of VX with human AChE and BChE from whole blood, erythrocyte membranes, erythrocytes, plasma, clinically available fresh frozen plasma and packed red blood cells. Obidoxime Chloride 54-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 27358236-4 2017 We here semiquantitatively investigate the ability of obidoxime and HI-6 to decrease the inhibitory activity of VX with human AChE and BChE from whole blood, erythrocyte membranes, erythrocytes, plasma, clinically available fresh frozen plasma and packed red blood cells. asoxime chloride 68-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 27342368-1 2017 An essential biological sensor for acetylcholine (ACh) detection is constructed by immobilizing enzymes, acetylcholinesterase (AChE) and choline oxidase (ChO), on the surface of iron oxide nanoparticles (Fe2O3NPs), poly(3,4-ethylenedioxythiophene) (PEDOT)-reduced graphene oxide (rGO) nanocomposite modified fluorine doped tin oxide (FTO). reduced graphene oxide 256-278 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 27342368-1 2017 An essential biological sensor for acetylcholine (ACh) detection is constructed by immobilizing enzymes, acetylcholinesterase (AChE) and choline oxidase (ChO), on the surface of iron oxide nanoparticles (Fe2O3NPs), poly(3,4-ethylenedioxythiophene) (PEDOT)-reduced graphene oxide (rGO) nanocomposite modified fluorine doped tin oxide (FTO). reduced graphene oxide 256-278 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 27342368-1 2017 An essential biological sensor for acetylcholine (ACh) detection is constructed by immobilizing enzymes, acetylcholinesterase (AChE) and choline oxidase (ChO), on the surface of iron oxide nanoparticles (Fe2O3NPs), poly(3,4-ethylenedioxythiophene) (PEDOT)-reduced graphene oxide (rGO) nanocomposite modified fluorine doped tin oxide (FTO). rgo 280-283 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 27342368-1 2017 An essential biological sensor for acetylcholine (ACh) detection is constructed by immobilizing enzymes, acetylcholinesterase (AChE) and choline oxidase (ChO), on the surface of iron oxide nanoparticles (Fe2O3NPs), poly(3,4-ethylenedioxythiophene) (PEDOT)-reduced graphene oxide (rGO) nanocomposite modified fluorine doped tin oxide (FTO). Acetylcholine 35-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 27342368-1 2017 An essential biological sensor for acetylcholine (ACh) detection is constructed by immobilizing enzymes, acetylcholinesterase (AChE) and choline oxidase (ChO), on the surface of iron oxide nanoparticles (Fe2O3NPs), poly(3,4-ethylenedioxythiophene) (PEDOT)-reduced graphene oxide (rGO) nanocomposite modified fluorine doped tin oxide (FTO). rgo 280-283 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 27342368-1 2017 An essential biological sensor for acetylcholine (ACh) detection is constructed by immobilizing enzymes, acetylcholinesterase (AChE) and choline oxidase (ChO), on the surface of iron oxide nanoparticles (Fe2O3NPs), poly(3,4-ethylenedioxythiophene) (PEDOT)-reduced graphene oxide (rGO) nanocomposite modified fluorine doped tin oxide (FTO). Fluorine 308-316 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 27342368-1 2017 An essential biological sensor for acetylcholine (ACh) detection is constructed by immobilizing enzymes, acetylcholinesterase (AChE) and choline oxidase (ChO), on the surface of iron oxide nanoparticles (Fe2O3NPs), poly(3,4-ethylenedioxythiophene) (PEDOT)-reduced graphene oxide (rGO) nanocomposite modified fluorine doped tin oxide (FTO). Fluorine 308-316 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 27342368-1 2017 An essential biological sensor for acetylcholine (ACh) detection is constructed by immobilizing enzymes, acetylcholinesterase (AChE) and choline oxidase (ChO), on the surface of iron oxide nanoparticles (Fe2O3NPs), poly(3,4-ethylenedioxythiophene) (PEDOT)-reduced graphene oxide (rGO) nanocomposite modified fluorine doped tin oxide (FTO). stannic oxide 323-332 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 27342368-1 2017 An essential biological sensor for acetylcholine (ACh) detection is constructed by immobilizing enzymes, acetylcholinesterase (AChE) and choline oxidase (ChO), on the surface of iron oxide nanoparticles (Fe2O3NPs), poly(3,4-ethylenedioxythiophene) (PEDOT)-reduced graphene oxide (rGO) nanocomposite modified fluorine doped tin oxide (FTO). stannic oxide 323-332 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 27342368-1 2017 An essential biological sensor for acetylcholine (ACh) detection is constructed by immobilizing enzymes, acetylcholinesterase (AChE) and choline oxidase (ChO), on the surface of iron oxide nanoparticles (Fe2O3NPs), poly(3,4-ethylenedioxythiophene) (PEDOT)-reduced graphene oxide (rGO) nanocomposite modified fluorine doped tin oxide (FTO). Acetylcholine 50-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 27342368-1 2017 An essential biological sensor for acetylcholine (ACh) detection is constructed by immobilizing enzymes, acetylcholinesterase (AChE) and choline oxidase (ChO), on the surface of iron oxide nanoparticles (Fe2O3NPs), poly(3,4-ethylenedioxythiophene) (PEDOT)-reduced graphene oxide (rGO) nanocomposite modified fluorine doped tin oxide (FTO). Acetylcholine 50-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 27342368-1 2017 An essential biological sensor for acetylcholine (ACh) detection is constructed by immobilizing enzymes, acetylcholinesterase (AChE) and choline oxidase (ChO), on the surface of iron oxide nanoparticles (Fe2O3NPs), poly(3,4-ethylenedioxythiophene) (PEDOT)-reduced graphene oxide (rGO) nanocomposite modified fluorine doped tin oxide (FTO). ferric oxide 178-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 27342368-1 2017 An essential biological sensor for acetylcholine (ACh) detection is constructed by immobilizing enzymes, acetylcholinesterase (AChE) and choline oxidase (ChO), on the surface of iron oxide nanoparticles (Fe2O3NPs), poly(3,4-ethylenedioxythiophene) (PEDOT)-reduced graphene oxide (rGO) nanocomposite modified fluorine doped tin oxide (FTO). ferric oxide 178-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 27342368-1 2017 An essential biological sensor for acetylcholine (ACh) detection is constructed by immobilizing enzymes, acetylcholinesterase (AChE) and choline oxidase (ChO), on the surface of iron oxide nanoparticles (Fe2O3NPs), poly(3,4-ethylenedioxythiophene) (PEDOT)-reduced graphene oxide (rGO) nanocomposite modified fluorine doped tin oxide (FTO). L 685458 334-337 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 27342368-1 2017 An essential biological sensor for acetylcholine (ACh) detection is constructed by immobilizing enzymes, acetylcholinesterase (AChE) and choline oxidase (ChO), on the surface of iron oxide nanoparticles (Fe2O3NPs), poly(3,4-ethylenedioxythiophene) (PEDOT)-reduced graphene oxide (rGO) nanocomposite modified fluorine doped tin oxide (FTO). fe2o3nps 204-212 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 27342368-1 2017 An essential biological sensor for acetylcholine (ACh) detection is constructed by immobilizing enzymes, acetylcholinesterase (AChE) and choline oxidase (ChO), on the surface of iron oxide nanoparticles (Fe2O3NPs), poly(3,4-ethylenedioxythiophene) (PEDOT)-reduced graphene oxide (rGO) nanocomposite modified fluorine doped tin oxide (FTO). L 685458 334-337 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 27342368-1 2017 An essential biological sensor for acetylcholine (ACh) detection is constructed by immobilizing enzymes, acetylcholinesterase (AChE) and choline oxidase (ChO), on the surface of iron oxide nanoparticles (Fe2O3NPs), poly(3,4-ethylenedioxythiophene) (PEDOT)-reduced graphene oxide (rGO) nanocomposite modified fluorine doped tin oxide (FTO). fe2o3nps 204-212 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 27342368-1 2017 An essential biological sensor for acetylcholine (ACh) detection is constructed by immobilizing enzymes, acetylcholinesterase (AChE) and choline oxidase (ChO), on the surface of iron oxide nanoparticles (Fe2O3NPs), poly(3,4-ethylenedioxythiophene) (PEDOT)-reduced graphene oxide (rGO) nanocomposite modified fluorine doped tin oxide (FTO). poly(3,4-ethylene dioxythiophene) 215-247 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 27342368-1 2017 An essential biological sensor for acetylcholine (ACh) detection is constructed by immobilizing enzymes, acetylcholinesterase (AChE) and choline oxidase (ChO), on the surface of iron oxide nanoparticles (Fe2O3NPs), poly(3,4-ethylenedioxythiophene) (PEDOT)-reduced graphene oxide (rGO) nanocomposite modified fluorine doped tin oxide (FTO). poly(3,4-ethylene dioxythiophene) 215-247 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 27342368-1 2017 An essential biological sensor for acetylcholine (ACh) detection is constructed by immobilizing enzymes, acetylcholinesterase (AChE) and choline oxidase (ChO), on the surface of iron oxide nanoparticles (Fe2O3NPs), poly(3,4-ethylenedioxythiophene) (PEDOT)-reduced graphene oxide (rGO) nanocomposite modified fluorine doped tin oxide (FTO). poly(3,4-ethylene dioxythiophene) 249-254 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 27342368-1 2017 An essential biological sensor for acetylcholine (ACh) detection is constructed by immobilizing enzymes, acetylcholinesterase (AChE) and choline oxidase (ChO), on the surface of iron oxide nanoparticles (Fe2O3NPs), poly(3,4-ethylenedioxythiophene) (PEDOT)-reduced graphene oxide (rGO) nanocomposite modified fluorine doped tin oxide (FTO). poly(3,4-ethylene dioxythiophene) 249-254 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 27785538-11 2017 PCR analyses suggested that the 11C-donepezil signal in inflammatory cells is derived from both acetylcholinesterase and sigma-1 receptors. Carbon-11 32-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 27785538-11 2017 PCR analyses suggested that the 11C-donepezil signal in inflammatory cells is derived from both acetylcholinesterase and sigma-1 receptors. Donepezil 36-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 28100726-1 2017 OBJECTIVE: To investigate systemic levels of acetylcholinesterase in early Parkinson disease (PD) with 11C-donepezil PET, a potential marker of parasympathetic innervation. Donepezil C-11 103-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 27939611-6 2017 At high concentration (1mM), trichlorfon induced effects similar to those of the neuropathic OP, mipafox (20muM), but also caused high inhibition of AChE. Trichlorfon 29-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 28180311-1 2017 Acetylcholinesterase (AChE), encoded by the ACHE gene, hydrolyzes the neurotransmitter acetylcholine to terminate synaptic transmission. Acetylcholine 87-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 28180311-1 2017 Acetylcholinesterase (AChE), encoded by the ACHE gene, hydrolyzes the neurotransmitter acetylcholine to terminate synaptic transmission. Acetylcholine 87-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 28180311-1 2017 Acetylcholinesterase (AChE), encoded by the ACHE gene, hydrolyzes the neurotransmitter acetylcholine to terminate synaptic transmission. Acetylcholine 87-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 28209997-4 2017 Furthermore, blockade of peripheral miR-132 by chemically protected AM132 antisense oligonucleotide elevated muscle AChE-R 10-fold over AChE-S, and cortical miRNA-sequencing demonstrated inverse brain changes by AM132 and LPS in immune-related miRs and neurotransmission and cholinergic signaling pathways. AM132 68-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 28209997-4 2017 Furthermore, blockade of peripheral miR-132 by chemically protected AM132 antisense oligonucleotide elevated muscle AChE-R 10-fold over AChE-S, and cortical miRNA-sequencing demonstrated inverse brain changes by AM132 and LPS in immune-related miRs and neurotransmission and cholinergic signaling pathways. Oligonucleotides 84-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 28209997-5 2017 In neuromuscular junctions, AM132 co-elevated the nicotinic acetylcholine receptor and AChE, re-balancing neurotransmission and reaching mild muscle incoordination. AM132 28-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 30183230-2 2017 Currently, drugs that are used symptomatically in the treatment of AD include acetylcholinesterase inhibitors (AChEIs) (rivastigmine, galantamine, donepezil) and N-methyl D-aspartate (NMDA) receptor antagonist (memantine). Rivastigmine 120-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 28165084-0 2017 Unbinding of fluorinated oxime drug from the AChE gorge in polarizable water: a well-tempered metadynamics study. Oximes 25-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 28165084-0 2017 Unbinding of fluorinated oxime drug from the AChE gorge in polarizable water: a well-tempered metadynamics study. Water 71-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 28165084-2 2017 Due to their enhanced ability to penetrate the blood brain barrier, they are suitable for reactivation of organophosphorus inactivated acetylcholinesterase (AChE) in the central nervous system. organophosphorus 106-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 28165084-2 2017 Due to their enhanced ability to penetrate the blood brain barrier, they are suitable for reactivation of organophosphorus inactivated acetylcholinesterase (AChE) in the central nervous system. organophosphorus 106-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 28165084-3 2017 We systematically studied the unbinding of fluorinated obidoxime (FOBI) and non-fluorinated obidoxime (OBI) from the active site gorge of the serine hydrolase AChE in mean field polarizable water by employing all atom molecular dynamics simulations. Obidoxime Chloride 55-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 28165084-3 2017 We systematically studied the unbinding of fluorinated obidoxime (FOBI) and non-fluorinated obidoxime (OBI) from the active site gorge of the serine hydrolase AChE in mean field polarizable water by employing all atom molecular dynamics simulations. Water 190-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 30183230-2 2017 Currently, drugs that are used symptomatically in the treatment of AD include acetylcholinesterase inhibitors (AChEIs) (rivastigmine, galantamine, donepezil) and N-methyl D-aspartate (NMDA) receptor antagonist (memantine). Galantamine 134-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 28225493-0 2017 Acetylcholinesterase inhibitor treatment alleviated cognitive impairment caused by delayed encephalopathy due to carbon monoxide poisoning: Two case reports and a review of the literature. Carbon Monoxide 113-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 27871793-0 2017 Combining in silico and in vitro approaches to evaluate the acetylcholinesterase inhibitory profile of some commercially available flavonoids in the management of Alzheimer"s disease. Flavonoids 131-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 27871793-1 2017 The current objective of the study is to identify inhibitory affinity potential of the certain commercially available flavonoids, against crystal structure of acetylcholinesterase (AChE) enzyme using in silico and in vitro studies. Flavonoids 118-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 27871793-1 2017 The current objective of the study is to identify inhibitory affinity potential of the certain commercially available flavonoids, against crystal structure of acetylcholinesterase (AChE) enzyme using in silico and in vitro studies. Flavonoids 118-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 27871793-2 2017 The inhibitory profiles of the compounds have been compared with standard AChE inhibitor donepezil. Donepezil 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 27871793-6 2017 In vitro results showed that all the selected flavonoids displayed excellent concentration-dependant inhibition of AChE. Flavonoids 46-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 28110700-4 2017 On the basis of preclinical studies, we hypothesize that Huperzine A (HupA), a safe and potent acetylcholinesterase (AChE) inhibitor with potentially disease-modifying qualities in AD, may have a realistic role as an anticonvulsant in AD. huperzine A 57-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 28110700-4 2017 On the basis of preclinical studies, we hypothesize that Huperzine A (HupA), a safe and potent acetylcholinesterase (AChE) inhibitor with potentially disease-modifying qualities in AD, may have a realistic role as an anticonvulsant in AD. huperzine A 57-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 28110700-4 2017 On the basis of preclinical studies, we hypothesize that Huperzine A (HupA), a safe and potent acetylcholinesterase (AChE) inhibitor with potentially disease-modifying qualities in AD, may have a realistic role as an anticonvulsant in AD. huperzine A 70-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 28110700-4 2017 On the basis of preclinical studies, we hypothesize that Huperzine A (HupA), a safe and potent acetylcholinesterase (AChE) inhibitor with potentially disease-modifying qualities in AD, may have a realistic role as an anticonvulsant in AD. huperzine A 70-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 28959629-10 2017 During exposure, the Cd treatments significantly influenced the biochemical markers (CAT, GR, GPx, GST and AChE). Cadmium 21-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 27311923-8 2017 Mass spectrometry for AChE, BChE and APH have characterized the active site serine adducts with OPs being useful to detect biomarkers of OPs exposure and inhibitory and postinhibitory reactions of esterases and OPs. Serine 76-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 28567126-6 2017 The hybrid compound containing the tryptoline moiety linked with a 7 carbon spacer to tacrine (14) displayed the best AChE and BuChE inhibitory activity (IC50 = 17.37 and 3.16 nM). tryptoline 35-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 28567126-6 2017 The hybrid compound containing the tryptoline moiety linked with a 7 carbon spacer to tacrine (14) displayed the best AChE and BuChE inhibitory activity (IC50 = 17.37 and 3.16 nM). Tacrine 86-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 27918993-0 2017 Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer"s disease therapy. tetrahydropyranodiquinolin-8-amines 0-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 30108764-0 2017 Synthesis and biological evaluation of 8-hydroxy-2,7-naphthyridin-2-ium salts as novel inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). 8-hydroxy-2,7-naphthyridin-2-ium salts 39-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 27951489-1 2017 Based on our recent investigations on chalcone derivatives as AChE inhibitors, a series of ferulic acid (FA) tertiary amine derivatives similar to chalcone compounds were designed and synthesized. ferulic acid 91-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 27951489-3 2017 The alteration of carbon chain linking tertiary amine groups and ferulic acid scaffold markedly influenced the inhibition activity against AChE. Carbon 18-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 27951489-3 2017 The alteration of carbon chain linking tertiary amine groups and ferulic acid scaffold markedly influenced the inhibition activity against AChE. Amines 48-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 27951489-3 2017 The alteration of carbon chain linking tertiary amine groups and ferulic acid scaffold markedly influenced the inhibition activity against AChE. ferulic acid 65-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 27951490-2 2017 The biological assay results demonstrate the ability of several quinazoline derivatives to inhibit both acetyl and butyrylcholinesterase (AChE and BuChE) enzymes (IC50 range = 1.6-30.5 muM), prevent beta-amyloid (Abeta) aggregation (IC50 range 270 nM-16.7 muM) and exhibit antioxidant properties (34-63.4% inhibition at 50 muM). Quinazolines 64-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 27951490-3 2017 Compound 9 (N2-(1-benzylpiperidin-4-yl)-N4-(3,4-dimethoxybenzyl)quinazoline-2,4-diamine) was identified as a dual inhibitor of cholinesterases (AChE IC50 = 2.1 muM; BuChE IC50 = 8.3 muM) and exhibited good inhibition of Abeta aggregation (Abeta40 IC50 = 2.3 muM). n2-(1-benzylpiperidin-4-yl)-n4-(3,4-dimethoxybenzyl)quinazoline-2,4-diamine 12-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 27611473-0 2017 Glutathione regulation-based dual-functional upconversion sensing-platform for acetylcholinesterase activity and cadmium ions. Glutathione 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 27611473-1 2017 A dual-functional platform for the sensing of acetylcholinesterase (AChE) activity and cadmium ions (Cd2+) was developed based on the fluorescence resonance energy transfer (FRET) between NaYF4:Yb,Er upconversion nanoparticles (UCNPs) and gold nanoparticles (AuNPs) via glutathione regulation. Glutathione 270-281 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 27611473-1 2017 A dual-functional platform for the sensing of acetylcholinesterase (AChE) activity and cadmium ions (Cd2+) was developed based on the fluorescence resonance energy transfer (FRET) between NaYF4:Yb,Er upconversion nanoparticles (UCNPs) and gold nanoparticles (AuNPs) via glutathione regulation. Glutathione 270-281 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 27611473-3 2017 AChE catalyzes the hydrolysis of acetylthiocholine (ATC) into thiocholine which reacts with AuNPs by S-Au conjunction and results the aggregation of AuNPs and change in fluorescence of UCNPs. Acetylthiocholine 33-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 27611473-3 2017 AChE catalyzes the hydrolysis of acetylthiocholine (ATC) into thiocholine which reacts with AuNPs by S-Au conjunction and results the aggregation of AuNPs and change in fluorescence of UCNPs. Acetylthiocholine 52-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 27611473-3 2017 AChE catalyzes the hydrolysis of acetylthiocholine (ATC) into thiocholine which reacts with AuNPs by S-Au conjunction and results the aggregation of AuNPs and change in fluorescence of UCNPs. Thiocholine 39-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 27611473-3 2017 AChE catalyzes the hydrolysis of acetylthiocholine (ATC) into thiocholine which reacts with AuNPs by S-Au conjunction and results the aggregation of AuNPs and change in fluorescence of UCNPs. Sulfur 101-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 27611473-6 2017 When Cd2+ is added into the stable mixture of AuNPs, GSH and AChE/ATC, Cd2+ could interact with GSH to form a spherical shaped (GSH)4Cd complex, which decreases the free GSH on the surface of AuNPs to weaken the stability of AuNPs and lead to the easily aggregation of them in the system. Glutathione 96-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 27611473-6 2017 When Cd2+ is added into the stable mixture of AuNPs, GSH and AChE/ATC, Cd2+ could interact with GSH to form a spherical shaped (GSH)4Cd complex, which decreases the free GSH on the surface of AuNPs to weaken the stability of AuNPs and lead to the easily aggregation of them in the system. (gsh)4cd 127-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 27611473-6 2017 When Cd2+ is added into the stable mixture of AuNPs, GSH and AChE/ATC, Cd2+ could interact with GSH to form a spherical shaped (GSH)4Cd complex, which decreases the free GSH on the surface of AuNPs to weaken the stability of AuNPs and lead to the easily aggregation of them in the system. Glutathione 96-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 27611473-9 2017 The small molecules regulated dual-functional platform based on UCNPs/AuNPs is a simple, label-free method and can be applied for the turn-on fluorescence detection of AChE activity in human serum and Cd2+ in real water samples. Water 214-219 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-172 27914796-0 2017 Design and synthesis of new piperidone grafted acetylcholinesterase inhibitors. Piperidones 28-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 27914796-3 2017 Two series of unreported N-benzylpiperidines 5(a-h) and thiazolopyrimidines 9(a-q) molecules were synthesized and evaluated in vitro for their acetylcholinesterase (AChE) inhibitory activities. 1-benzylpiperidine 25-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 27914796-3 2017 Two series of unreported N-benzylpiperidines 5(a-h) and thiazolopyrimidines 9(a-q) molecules were synthesized and evaluated in vitro for their acetylcholinesterase (AChE) inhibitory activities. 1-benzylpiperidine 25-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 27914796-3 2017 Two series of unreported N-benzylpiperidines 5(a-h) and thiazolopyrimidines 9(a-q) molecules were synthesized and evaluated in vitro for their acetylcholinesterase (AChE) inhibitory activities. thiazolopyrimidines 56-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 27914796-4 2017 Among the newly synthesized compounds, 5h, 9h, 9j, and 9p displayed higher AChE enzyme inhibitory activities than the standard drug, galantamine, with IC50 values of 0.83, 0.98, and 0.73muM, respectively. 5h 39-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 27914796-4 2017 Among the newly synthesized compounds, 5h, 9h, 9j, and 9p displayed higher AChE enzyme inhibitory activities than the standard drug, galantamine, with IC50 values of 0.83, 0.98, and 0.73muM, respectively. Galantamine 133-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 28117700-2 2017 Here, a series of symmetrical molecules containing biphenyl/bibenzyl scaffolds (12-36) were designed, synthesized, and evaluated for their ability to inhibit both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Bibenzyls 60-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-183 28117700-2 2017 Here, a series of symmetrical molecules containing biphenyl/bibenzyl scaffolds (12-36) were designed, synthesized, and evaluated for their ability to inhibit both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Bibenzyls 60-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 185-189 28149268-2 2016 These compounds potently inhibit acetylcholinesterase (AChE), the enzyme that inactivates acetylcholine at neuronal synapses, and acute exposure to high OP levels can cause cholinergic crisis in humans and animals. Acetylcholine 33-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 30108764-0 2017 Synthesis and biological evaluation of 8-hydroxy-2,7-naphthyridin-2-ium salts as novel inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). 8-hydroxy-2,7-naphthyridin-2-ium salts 39-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 30108764-1 2017 By analogy with the natural product chelerythrine, which has been identified as an inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), we prepared a small series of 8-hydroxy-2,7-naphthyridin-2-ium salts. chelerythrine 36-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 30108764-1 2017 By analogy with the natural product chelerythrine, which has been identified as an inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), we prepared a small series of 8-hydroxy-2,7-naphthyridin-2-ium salts. chelerythrine 36-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 30108764-1 2017 By analogy with the natural product chelerythrine, which has been identified as an inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), we prepared a small series of 8-hydroxy-2,7-naphthyridin-2-ium salts. 8-hydroxy-2,7-naphthyridin-2-ium salts 193-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 30108764-1 2017 By analogy with the natural product chelerythrine, which has been identified as an inhibitor of both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), we prepared a small series of 8-hydroxy-2,7-naphthyridin-2-ium salts. 8-hydroxy-2,7-naphthyridin-2-ium salts 193-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 28061690-1 2017 Originally, organophosphorus (OP) toxicology consisted of acetylcholinesterase inhibition by insecticides and chemical threat agents acting as phosphorylating agents for serine in the catalytic triad, but this is no longer the case. organophosphorus 12-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 28061690-1 2017 Originally, organophosphorus (OP) toxicology consisted of acetylcholinesterase inhibition by insecticides and chemical threat agents acting as phosphorylating agents for serine in the catalytic triad, but this is no longer the case. Serine 170-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 32263440-5 2017 We also extended the one-step method to detect acetylcholine (ACh) by taking advantage of the specific catalytic reaction of acetylcholinesterase (AChE) and choline oxidase (ChOx). Acetylcholine 47-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 32263440-5 2017 We also extended the one-step method to detect acetylcholine (ACh) by taking advantage of the specific catalytic reaction of acetylcholinesterase (AChE) and choline oxidase (ChOx). Acetylcholine 62-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 27721153-3 2017 In vitro studies showed that the majority of saccharin derivatives with piperazine moiety and one phthalimide derivative with 3-aminopiperidine fragment exhibited inhibitory potency toward acetylcholinesterase (AChE) with EeAChE IC50 values ranging from 0.83 muM to 19.18 muM. Saccharin 45-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-209 27721153-3 2017 In vitro studies showed that the majority of saccharin derivatives with piperazine moiety and one phthalimide derivative with 3-aminopiperidine fragment exhibited inhibitory potency toward acetylcholinesterase (AChE) with EeAChE IC50 values ranging from 0.83 muM to 19.18 muM. Saccharin 45-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-215 27721153-3 2017 In vitro studies showed that the majority of saccharin derivatives with piperazine moiety and one phthalimide derivative with 3-aminopiperidine fragment exhibited inhibitory potency toward acetylcholinesterase (AChE) with EeAChE IC50 values ranging from 0.83 muM to 19.18 muM. Piperazine 72-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-215 27721153-3 2017 In vitro studies showed that the majority of saccharin derivatives with piperazine moiety and one phthalimide derivative with 3-aminopiperidine fragment exhibited inhibitory potency toward acetylcholinesterase (AChE) with EeAChE IC50 values ranging from 0.83 muM to 19.18 muM. phthalimide 98-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-209 27721153-3 2017 In vitro studies showed that the majority of saccharin derivatives with piperazine moiety and one phthalimide derivative with 3-aminopiperidine fragment exhibited inhibitory potency toward acetylcholinesterase (AChE) with EeAChE IC50 values ranging from 0.83 muM to 19.18 muM. phthalimide 98-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-215 27721153-3 2017 In vitro studies showed that the majority of saccharin derivatives with piperazine moiety and one phthalimide derivative with 3-aminopiperidine fragment exhibited inhibitory potency toward acetylcholinesterase (AChE) with EeAChE IC50 values ranging from 0.83 muM to 19.18 muM. Piperidin-3-amine 126-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-209 27721153-3 2017 In vitro studies showed that the majority of saccharin derivatives with piperazine moiety and one phthalimide derivative with 3-aminopiperidine fragment exhibited inhibitory potency toward acetylcholinesterase (AChE) with EeAChE IC50 values ranging from 0.83 muM to 19.18 muM. Piperidin-3-amine 126-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-215 27721157-4 2017 Among the entire series compounds IP-9, IP-13 and IP-15 appeared as most active multi-functional agents and displayed marked AChE inhibitory, Abeta disaggregation and antioxidant activity. indeno(1,2,3-cd)pyrene 34-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 27721157-5 2017 Studies indicate that IP-13 and IP-15 showed better AChE inhibitory activity than the standard drug donepezil and IP-9, IP-13 as well as IP-15 exhibited better Abeta aggregation inhibitory activity than curcumin. indeno(1,2,3-cd)pyrene 22-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 27721157-5 2017 Studies indicate that IP-13 and IP-15 showed better AChE inhibitory activity than the standard drug donepezil and IP-9, IP-13 as well as IP-15 exhibited better Abeta aggregation inhibitory activity than curcumin. ip-13 22-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 27721157-8 2017 To elucidate the plausible binding mode of the compounds IP-9, IP-13 and IP-15, molecular docking studies and molecular dynamics (MD) simulation studies were also performed and the results indicate their significant interactions with the active sites of AChE as well as Abeta1-42 peptide. indeno(1,2,3-cd)pyrene 57-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 254-258 27863370-5 2017 Also, molecular modeling and kinetic studies showed that compounds 5l and 5j bound simultaneously to the peripheral anionic site (PAS) and catalytic sites (CS) of the AChE and BChE. Aminosalicylic Acid 130-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 28163969-6 2017 MATERIALS AND METHODS: The crude methanol extract was prepared by cold extraction method and was assessed for acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities by the Ellman"s method. Methanol 33-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 27591048-0 2017 Differential inhibition of human erythrocyte acetylcholinesterase by polyphenols epigallocatechin-3-gallate and resveratrol. polyphenols epigallocatechin-3-gallate 69-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 27591048-0 2017 Differential inhibition of human erythrocyte acetylcholinesterase by polyphenols epigallocatechin-3-gallate and resveratrol. Resveratrol 112-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 27591048-2 2017 The activity of acetylcholinesterase (AChE) from human erythrocytes was tested in the presence of the phenolic compounds resveratrol and epigallocatechin-3-gallate (EGCG). Resveratrol 121-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 27591048-2 2017 The activity of acetylcholinesterase (AChE) from human erythrocytes was tested in the presence of the phenolic compounds resveratrol and epigallocatechin-3-gallate (EGCG). Resveratrol 121-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 27591048-2 2017 The activity of acetylcholinesterase (AChE) from human erythrocytes was tested in the presence of the phenolic compounds resveratrol and epigallocatechin-3-gallate (EGCG). epigallocatechin gallate 137-163 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 27591048-2 2017 The activity of acetylcholinesterase (AChE) from human erythrocytes was tested in the presence of the phenolic compounds resveratrol and epigallocatechin-3-gallate (EGCG). epigallocatechin gallate 137-163 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 27591048-2 2017 The activity of acetylcholinesterase (AChE) from human erythrocytes was tested in the presence of the phenolic compounds resveratrol and epigallocatechin-3-gallate (EGCG). epigallocatechin gallate 165-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 27591048-2 2017 The activity of acetylcholinesterase (AChE) from human erythrocytes was tested in the presence of the phenolic compounds resveratrol and epigallocatechin-3-gallate (EGCG). epigallocatechin gallate 165-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 27591048-3 2017 Even though the stilbene barely changed this enzymatic activity, EGCG did inhibit AChE. epigallocatechin gallate 65-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 27591048-5 2017 Actually, it was shown that this flavonoid may bind to the red blood cell membrane surface, which may improve the interaction between EGCG and AChE. Flavonoids 33-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 27591048-5 2017 Actually, it was shown that this flavonoid may bind to the red blood cell membrane surface, which may improve the interaction between EGCG and AChE. epigallocatechin gallate 134-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 28034279-9 2017 Inhibition of acetylcholinesterase activity was also potent and was in the following order: celecoxib> piroxicam> diclofenac> aspirin> indomethacin> dexamethasone. Celecoxib 92-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 28034279-9 2017 Inhibition of acetylcholinesterase activity was also potent and was in the following order: celecoxib> piroxicam> diclofenac> aspirin> indomethacin> dexamethasone. Piroxicam 106-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 28034279-9 2017 Inhibition of acetylcholinesterase activity was also potent and was in the following order: celecoxib> piroxicam> diclofenac> aspirin> indomethacin> dexamethasone. Diclofenac 120-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 28034279-9 2017 Inhibition of acetylcholinesterase activity was also potent and was in the following order: celecoxib> piroxicam> diclofenac> aspirin> indomethacin> dexamethasone. Aspirin 135-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 28034279-9 2017 Inhibition of acetylcholinesterase activity was also potent and was in the following order: celecoxib> piroxicam> diclofenac> aspirin> indomethacin> dexamethasone. Indomethacin 147-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 28034279-9 2017 Inhibition of acetylcholinesterase activity was also potent and was in the following order: celecoxib> piroxicam> diclofenac> aspirin> indomethacin> dexamethasone. Dexamethasone 164-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 28403780-0 2017 Synthesis of Novel Benzothiazole-Piperazine Derivatives and Their Biological Evaluation as Acetylcholinesterase Inhibitors and Cytotoxic Agents. benzothiazole-piperazine 19-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 28403780-7 2017 Docking study was utilized to understand the binding mode of compound 2j in comparision with donepezil on AChE. Donepezil 93-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 28840133-0 2017 Whole-Body Distribution of Donepezil as an Acetylcholinesterase Inhibitor after Oral Administration in Normal Human Subjects: A 11C-donepezil PET Study. Donepezil 27-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 28840133-2 2017 Therefore, we aimed to examine the whole-body distribution of donepezil (DNP) as an acetylcholinesterase inhibitor by means of 11C-DNP PET imaging, combined with the oral administration of pharmacological doses of DNP. Donepezil 62-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 28840133-2 2017 Therefore, we aimed to examine the whole-body distribution of donepezil (DNP) as an acetylcholinesterase inhibitor by means of 11C-DNP PET imaging, combined with the oral administration of pharmacological doses of DNP. Donepezil 73-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 28966245-0 2017 Long-Lasting Inhibitory Effects of Distigmine on Recombinant Human Acetylcholinesterase Activity. distigmine 35-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 28966245-1 2017 To elucidate the mechanism whereby distigmine, an underactive bladder remedy, potentiates urinary bladder contractions long-lastingly, the inhibition of recombinant human acetylcholinesterase (rhAChE) by distigmine was investigated. distigmine 35-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-191 28966245-1 2017 To elucidate the mechanism whereby distigmine, an underactive bladder remedy, potentiates urinary bladder contractions long-lastingly, the inhibition of recombinant human acetylcholinesterase (rhAChE) by distigmine was investigated. distigmine 204-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-191 28966245-10 2017 Based on the t1/2 values, distigmine was judged to dissociate from acetylcholinesterase (AChE) 40-120-fold slower than the other ChE inhibitors did. distigmine 26-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 28966245-10 2017 Based on the t1/2 values, distigmine was judged to dissociate from acetylcholinesterase (AChE) 40-120-fold slower than the other ChE inhibitors did. distigmine 26-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 28785576-2 2017 It acts as antagonist of muscarinic receptor activated by acetylcholine while the enzyme acetylcholinesterase (AChE) cleaves acetylcholine in synaptic junction into choline and acetic acid. Acetylcholine 58-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 28785576-2 2017 It acts as antagonist of muscarinic receptor activated by acetylcholine while the enzyme acetylcholinesterase (AChE) cleaves acetylcholine in synaptic junction into choline and acetic acid. Acetylcholine 89-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 28785576-2 2017 It acts as antagonist of muscarinic receptor activated by acetylcholine while the enzyme acetylcholinesterase (AChE) cleaves acetylcholine in synaptic junction into choline and acetic acid. Acetic Acid 177-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 28785576-2 2017 It acts as antagonist of muscarinic receptor activated by acetylcholine while the enzyme acetylcholinesterase (AChE) cleaves acetylcholine in synaptic junction into choline and acetic acid. Acetic Acid 177-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 28785576-6 2017 The lowest predicted binding energy was -7.84 kcal/mol corresponding to H-bond between biperiden molecule and Tyr 341 residuum in protein structure of AChE. Biperiden 87-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 28785576-6 2017 The lowest predicted binding energy was -7.84 kcal/mol corresponding to H-bond between biperiden molecule and Tyr 341 residuum in protein structure of AChE. Tyrosine 110-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 28894751-0 2017 Peripheral Inhibitor of AChE, Neostigmine, Prevents the Inflammatory Dependent Suppression of GnRH/LH Secretion during the Follicular Phase of the Estrous Cycle. Neostigmine 30-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 28894751-1 2017 The study was designed to test the hypothesis that the inhibition of acetylcholinesterase (AChE) activity at the periphery by Neostigmine (0.5 mg/animal) will be sufficient to prevent inflammatory dependent suppression of the gonadotropin-releasing hormone (GnRH)/luteinising hormone (LH) secretion in ewes in the follicular phase of the estrous cycle, and this effect will be comparable with the systemic AChE inhibitor, Donepezil (2.5 mg/animal). Donepezil 422-431 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 28894751-6 2017 Our study shows that inflammatory dependent changes in the GnRH/LH secretion may be eliminated or reduced by AChE inhibitors suppressing inflammatory reaction only at the periphery such as Neostigmine, without the need for interfering in the central nervous system. Neostigmine 189-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 27780618-0 2017 Synthesis, structure-activity relationship and molecular docking of 3-oxoaurones and 3-thioaurones as acetylcholinesterase and butyrylcholinesterase inhibitors. 3-oxoaurones 68-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 27780618-0 2017 Synthesis, structure-activity relationship and molecular docking of 3-oxoaurones and 3-thioaurones as acetylcholinesterase and butyrylcholinesterase inhibitors. 3-thioaurones 85-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 28243607-2 2017 In this study, we aimed to demonstrate the role of sildenafil (an antagonist of phosphodiesterase type 5 (PDE-5)) and donepezil (a specific and reversible inhibitor of acetylcholinesterase (Ach)) in increasing ischemia-induced angiogenesis. Donepezil 118-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-188 28595532-8 2017 RESULTS: The harmane-beta-carboline alkaloid has shown several pharmacological activities such as antianxiety, antidepressant, antiplatelet, antidiabetic, acetylcholinesterase and myeloperoxidase inhibition, antioxidant, antiparasitic, hypotensive, morphine withdrawal syndrome alleviation, and antinociceptive effects. harman 13-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-175 28595532-8 2017 RESULTS: The harmane-beta-carboline alkaloid has shown several pharmacological activities such as antianxiety, antidepressant, antiplatelet, antidiabetic, acetylcholinesterase and myeloperoxidase inhibition, antioxidant, antiparasitic, hypotensive, morphine withdrawal syndrome alleviation, and antinociceptive effects. beta-carboline alkaloid 21-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-175 28176636-8 2017 Since AgAChE possesses an unpaired Cys residue not present in mammalian AChE, a logical strategy to achieve selective inhibition involves design of compounds that could ligate that Cys. Cysteine 35-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-12 28176636-8 2017 Since AgAChE possesses an unpaired Cys residue not present in mammalian AChE, a logical strategy to achieve selective inhibition involves design of compounds that could ligate that Cys. Cysteine 181-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-12 28294041-2 2017 In particular, tacrine, a well known Acetylcholinesterase inhibitor, is one of the most used starting point to develop multifunctional ligands and hundreds of papers report about these new agents. Tacrine 15-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 28685687-1 2017 BACKGROUND: Acetylcholinesterase (AChE) is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. Acetylcholine 139-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 28685687-1 2017 BACKGROUND: Acetylcholinesterase (AChE) is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. Acetylcholine 139-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 27697055-9 2017 In particular, it focuses on THA hybrids capable of scavenging reactive oxygen species (ROS), and derivatives which reduce the formation of Abeta-plaques either directly by confronting the Abeta1-42 selfaggregation process or indirectly by inhibiting the BACE-1 enzyme or AChE-induced Abeta1-40 aggregation. Tacrine 29-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 272-276 27984137-0 2017 Novel eugenol derivatives: Potent acetylcholinesterase and carbonic anhydrase inhibitors. Eugenol 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 27984137-11 2017 Also, AChE was inhibited by tacrine as an AChE inhibitor at the 71.18nM level. Tacrine 28-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 27984137-11 2017 Also, AChE was inhibited by tacrine as an AChE inhibitor at the 71.18nM level. Tacrine 28-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 28133526-0 2017 2-(2-(4-Benzoylpiperazin-1-yl)ethyl)isoindoline-1,3-dione derivatives: Synthesis, docking and acetylcholinesterase inhibitory evaluation as anti-alzheimer agents. 2-(2-(4-benzoylpiperazin-1-yl)ethyl)isoindoline-1,3-dione 0-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 28133526-2 2017 Therefore, administration of the acetylcholinesterase (AChE) inhibitors such as donepezil is the first choice for treatment of the AD. Donepezil 80-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 28133526-2 2017 Therefore, administration of the acetylcholinesterase (AChE) inhibitors such as donepezil is the first choice for treatment of the AD. Donepezil 80-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 28133526-9 2017 Moreover, a similar binding mode was observed in silico for all ligands in superimposition state with donepezil into the active site of acetylcholinesterase. Donepezil 102-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 27858711-2 2017 As expected from this CNS selectivity, the irreversible AChE inhibitor methanesulfonyl fluoride (MSF) produces significant cognitive improvement in Alzheimer"s disease patients without the gastrointestinal toxicity that plagues other AChE inhibitors. methanesulfonyl fluoride 71-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 27858711-2 2017 As expected from this CNS selectivity, the irreversible AChE inhibitor methanesulfonyl fluoride (MSF) produces significant cognitive improvement in Alzheimer"s disease patients without the gastrointestinal toxicity that plagues other AChE inhibitors. methanesulfonyl fluoride 71-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 234-238 27858711-2 2017 As expected from this CNS selectivity, the irreversible AChE inhibitor methanesulfonyl fluoride (MSF) produces significant cognitive improvement in Alzheimer"s disease patients without the gastrointestinal toxicity that plagues other AChE inhibitors. methanesulfonyl fluoride 97-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 27858711-2 2017 As expected from this CNS selectivity, the irreversible AChE inhibitor methanesulfonyl fluoride (MSF) produces significant cognitive improvement in Alzheimer"s disease patients without the gastrointestinal toxicity that plagues other AChE inhibitors. methanesulfonyl fluoride 97-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 234-238 27911294-1 2017 BACKGROUND: Donepezil is an acetylcholinesterase inhibitor frequently prescribed for the treatment of mild cognitive impairment (MCI) though not approved by the Food and Drug Administration for this indication. Donepezil 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 27914299-7 2017 In the second section, the effect of fluorination on the drug enzyme interactions was evaluated by using two effective methods Based on the molecular docking and density functional theory (DFT) calculations fluorine substitution influenced the Donepezil Acetylcholinesterase interactions. Fluorine 207-215 acetylcholinesterase (Cartwright blood group) Homo sapiens 254-274 27914299-7 2017 In the second section, the effect of fluorination on the drug enzyme interactions was evaluated by using two effective methods Based on the molecular docking and density functional theory (DFT) calculations fluorine substitution influenced the Donepezil Acetylcholinesterase interactions. Donepezil 244-253 acetylcholinesterase (Cartwright blood group) Homo sapiens 254-274 27664791-3 2017 Previously, using oligodendrocyte progenitor cells, we have shown that donepezil, which is an acetylcholinesterase inhibitor developed for the treatment of Alzheimer"s disease, stimulates myelin gene expression and oligodendrocyte differentiation. Donepezil 71-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 28545385-0 2017 Effect on Acetylcholinesterase and Anti-oxidant Activity of Synthetic Chalcones having a Good Predicted Pharmacokinetic Profile. Chalcones 70-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-30 27923535-0 2017 Multitarget drug design strategy against Alzheimer"s disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties. homoisoflavonoid 62-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-133 27923535-0 2017 Multitarget drug design strategy against Alzheimer"s disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties. Mannich Bases 79-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-133 28117022-1 2017 Acetylcholinesterase is a serine hydrolase that terminates the action of the neurotransmitter acetylcholine by hydrolyzing it into acetic acid and choline. Acetylcholine 94-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 28117022-1 2017 Acetylcholinesterase is a serine hydrolase that terminates the action of the neurotransmitter acetylcholine by hydrolyzing it into acetic acid and choline. Acetic Acid 131-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 28117022-3 2017 The acetylcholinesterase inhibitors bind to the molecule and interfere with the breakdown of acetylcholine leading to the deposition of acetylcholine in the nerve synapses and causing disrupted neurotransmission. Acetylcholine 93-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 28545385-2 2017 In this work, we investigated the effect of twenty-two synthesized chalcones on AChE activity. Chalcones 67-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 28545385-3 2017 OBJECTIVE: This work is aimed to synthesize and evaluate the effect of chalcones on the AChE activity, as well as anti-oxidant activity and predict their pharmacokinetic profile. Chalcones 71-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 28545385-4 2017 METHOD: Chalcones were synthesized through a Claisen-Schmidt condensation and their inhibitory effect on the AChE was evaluated by the Elmann"s colorimetric method. Chalcones 8-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 27793617-3 2016 Galanthamine is an acetylcholinesterase inhibitor (AChEI) used to symptomatic treatment of Alzheimers disease (AD). Galantamine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 28770024-4 2017 The aim of this study was to assess in vitro the effects of metformin, phenformin, and metformin sulfenamide prodrugs on the activity of human AChE and butyrylcholinesterase (BuChE) and establish the type of inhibition. Metformin 60-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 28770024-4 2017 The aim of this study was to assess in vitro the effects of metformin, phenformin, and metformin sulfenamide prodrugs on the activity of human AChE and butyrylcholinesterase (BuChE) and establish the type of inhibition. Phenformin 71-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 28770024-4 2017 The aim of this study was to assess in vitro the effects of metformin, phenformin, and metformin sulfenamide prodrugs on the activity of human AChE and butyrylcholinesterase (BuChE) and establish the type of inhibition. metformin sulfenamide 87-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 28770024-5 2017 Metformin inhibited 50% of the AChE activity at micromolar concentrations (2.35 mumol/mL, mixed type of inhibition) and seemed to be selective towards AChE since it presented low anti-BuChE activity. Metformin 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 28770024-5 2017 Metformin inhibited 50% of the AChE activity at micromolar concentrations (2.35 mumol/mL, mixed type of inhibition) and seemed to be selective towards AChE since it presented low anti-BuChE activity. Metformin 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 28770024-7 2017 The cyclohexyl sulfenamide prodrug demonstrated the highest activity towards both AChE (IC50 = 890 nmol/mL, noncompetitive inhibition) and BuChE (IC50 = 28 nmol/mL, mixed type inhibition), while the octyl sulfenamide prodrug did not present anti-AChE activity, but exhibited mixed inhibition towards BuChE (IC50 = 184 nmol/mL). cyclohexyl sulfenamide 4-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 28770024-7 2017 The cyclohexyl sulfenamide prodrug demonstrated the highest activity towards both AChE (IC50 = 890 nmol/mL, noncompetitive inhibition) and BuChE (IC50 = 28 nmol/mL, mixed type inhibition), while the octyl sulfenamide prodrug did not present anti-AChE activity, but exhibited mixed inhibition towards BuChE (IC50 = 184 nmol/mL). cyclohexyl sulfenamide 4-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 246-250 28770024-7 2017 The cyclohexyl sulfenamide prodrug demonstrated the highest activity towards both AChE (IC50 = 890 nmol/mL, noncompetitive inhibition) and BuChE (IC50 = 28 nmol/mL, mixed type inhibition), while the octyl sulfenamide prodrug did not present anti-AChE activity, but exhibited mixed inhibition towards BuChE (IC50 = 184 nmol/mL). octyl sulfenamide 199-216 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 28770024-9 2017 In conclusion, it was demonstrated that biguanides present a novel class of inhibitors for AChE and BuChE and encourages further studies of these compounds for developing both selective and nonselective inhibitors of ChEs in the future. Biguanides 40-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 27498323-4 2016 Herein, we reported a simple paper-based fluorescent sensor (PFS) based on the aggregation induced emission (AIE) effect of tetraphenylethylene (TPE) and the addition reaction capability of maleimide, which has been used as a powerful tool for rapid naked-eye detection of AChE activity and OPs. tetraphenylethylene 124-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 273-277 27498323-4 2016 Herein, we reported a simple paper-based fluorescent sensor (PFS) based on the aggregation induced emission (AIE) effect of tetraphenylethylene (TPE) and the addition reaction capability of maleimide, which has been used as a powerful tool for rapid naked-eye detection of AChE activity and OPs. maleimide 190-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 273-277 27498323-6 2016 The hydrolysis product of acetylthiocholine catalyzed by AChE induced the maleimide ring destruction and activated the fluorescence performance of TPE. Acetylthiocholine 26-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 27498323-6 2016 The hydrolysis product of acetylthiocholine catalyzed by AChE induced the maleimide ring destruction and activated the fluorescence performance of TPE. maleimide 74-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 28018854-5 2017 Acetylcholinesterase (AChE) activity was quantitatively measured in the neo- and allocortex using N-[11C]-Methylpiperidin-4-yl propionate (PMP)-PET with arterial sampling and metabolite correction. n-[11c]-methylpiperidin-4-yl propionate 98-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 28018854-5 2017 Acetylcholinesterase (AChE) activity was quantitatively measured in the neo- and allocortex using N-[11C]-Methylpiperidin-4-yl propionate (PMP)-PET with arterial sampling and metabolite correction. n-[11c]-methylpiperidin-4-yl propionate 98-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 28018854-5 2017 Acetylcholinesterase (AChE) activity was quantitatively measured in the neo- and allocortex using N-[11C]-Methylpiperidin-4-yl propionate (PMP)-PET with arterial sampling and metabolite correction. pmp 139-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 28018854-5 2017 Acetylcholinesterase (AChE) activity was quantitatively measured in the neo- and allocortex using N-[11C]-Methylpiperidin-4-yl propionate (PMP)-PET with arterial sampling and metabolite correction. pmp 139-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 27582056-1 2016 Irreversible inhibition of acetylcholinesterase (AChE) by organophosphates leads to many failures in living organism and ultimately in death. Organophosphates 58-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 27582056-1 2016 Irreversible inhibition of acetylcholinesterase (AChE) by organophosphates leads to many failures in living organism and ultimately in death. Organophosphates 58-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 27582056-5 2016 Basic treatments for these intoxications are based on immediate administration of atropine and acetylcholinesterase reactivators which are currently represented by mono- or bis-pyridinium aldoximes. mono- or bis-pyridinium 164-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 27582056-9 2016 Among further modifications of known oximes, the main attention has been paid to dual binding site ligands of AChE as the current mainstream strategy. Oximes 37-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 27750058-0 2016 Rational design and synthesis of dihydropyrimidine based dual binding site acetylcholinesterase inhibitors. dihydropyrimidine 33-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 27750058-1 2016 Based on the pharmacological importance of dihydropyrimidine (DHPM) scaffold, substituted DHPMs linked with acetamide linker to substituted aromatic anilines were synthesized and evaluated for their potency as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. dihydropyrimidine 43-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-230 27750058-1 2016 Based on the pharmacological importance of dihydropyrimidine (DHPM) scaffold, substituted DHPMs linked with acetamide linker to substituted aromatic anilines were synthesized and evaluated for their potency as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. dihydropyrimidine 43-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 232-236 27750058-1 2016 Based on the pharmacological importance of dihydropyrimidine (DHPM) scaffold, substituted DHPMs linked with acetamide linker to substituted aromatic anilines were synthesized and evaluated for their potency as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate 62-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-230 27750058-1 2016 Based on the pharmacological importance of dihydropyrimidine (DHPM) scaffold, substituted DHPMs linked with acetamide linker to substituted aromatic anilines were synthesized and evaluated for their potency as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate 62-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 232-236 27750058-1 2016 Based on the pharmacological importance of dihydropyrimidine (DHPM) scaffold, substituted DHPMs linked with acetamide linker to substituted aromatic anilines were synthesized and evaluated for their potency as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. dhpms 90-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-230 27750058-1 2016 Based on the pharmacological importance of dihydropyrimidine (DHPM) scaffold, substituted DHPMs linked with acetamide linker to substituted aromatic anilines were synthesized and evaluated for their potency as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. dhpms 90-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 232-236 27750058-1 2016 Based on the pharmacological importance of dihydropyrimidine (DHPM) scaffold, substituted DHPMs linked with acetamide linker to substituted aromatic anilines were synthesized and evaluated for their potency as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. acetamide 108-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-230 27750058-1 2016 Based on the pharmacological importance of dihydropyrimidine (DHPM) scaffold, substituted DHPMs linked with acetamide linker to substituted aromatic anilines were synthesized and evaluated for their potency as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. aromatic anilines 140-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-230 27750058-2 2016 The good AChE inhibitory activity of 4-dihydropyrimidine-2-thione (4a-h) and 2-amino-1,4-dihyropyrimidines (5a-h) series was observed with compound 4a and 4d identified as the most potent compounds with IC50 values of 0.17+-0.01 and 0.39+-0.04muMrespectively. 4-dihydropyrimidine-2-thione 37-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 27750058-2 2016 The good AChE inhibitory activity of 4-dihydropyrimidine-2-thione (4a-h) and 2-amino-1,4-dihyropyrimidines (5a-h) series was observed with compound 4a and 4d identified as the most potent compounds with IC50 values of 0.17+-0.01 and 0.39+-0.04muMrespectively. 2-amino-1,4-dihyropyrimidines 77-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 26612005-0 2016 Docking and molecular dynamics studies of peripheral site ligand-oximes as reactivators of sarin-inhibited human acetylcholinesterase. Oximes 65-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-133 26612005-1 2016 In the present work, we performed docking and molecular dynamics simulations studies on two groups of long-tailored oximes designed as peripheral site binders of acetylcholinesterase (AChE) and potential penetrators on the blood brain barrier. Oximes 116-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-182 26453427-3 2016 Acetylcholinesterase (AChE) is responsible for acetyl choline (ACh) hydrolysis and plays a fundamental role in nerve impulse transmission by terminating the action of the ACh neurotransmitter at cholinergic synapses and neuromuscular junctions. Acetylcholine 47-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 26453427-3 2016 Acetylcholinesterase (AChE) is responsible for acetyl choline (ACh) hydrolysis and plays a fundamental role in nerve impulse transmission by terminating the action of the ACh neurotransmitter at cholinergic synapses and neuromuscular junctions. Acetylcholine 47-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 26453427-3 2016 Acetylcholinesterase (AChE) is responsible for acetyl choline (ACh) hydrolysis and plays a fundamental role in nerve impulse transmission by terminating the action of the ACh neurotransmitter at cholinergic synapses and neuromuscular junctions. Acetylcholine 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 26453427-3 2016 Acetylcholinesterase (AChE) is responsible for acetyl choline (ACh) hydrolysis and plays a fundamental role in nerve impulse transmission by terminating the action of the ACh neurotransmitter at cholinergic synapses and neuromuscular junctions. Acetylcholine 63-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 26453427-3 2016 Acetylcholinesterase (AChE) is responsible for acetyl choline (ACh) hydrolysis and plays a fundamental role in nerve impulse transmission by terminating the action of the ACh neurotransmitter at cholinergic synapses and neuromuscular junctions. Acetylcholine 63-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 26453427-6 2016 In the present study, the inhibition effect of CAPE on human carbonic anhydrase (hCA) isoforms I, II, IX, and XII, AChE, BChE, LPO, and GST was evaluated. caffeic acid phenethyl ester 47-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 26558640-0 2016 Design, synthesis, and evaluation of guanylhydrazones as potential inhibitors or reactivators of acetylcholinesterase. Mitoguazone 37-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 26558640-1 2016 Analogs of pralidoxime, which is a commercial antidote for intoxication from neurotoxic organophosphorus compounds, were designed, synthesized, characterized, and tested as potential inhibitors or reactivators of acetylcholinesterase (AChE) using the Ellman"s test, nuclear magnetic resonance, and molecular modeling. pralidoxime 11-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-233 26558640-1 2016 Analogs of pralidoxime, which is a commercial antidote for intoxication from neurotoxic organophosphorus compounds, were designed, synthesized, characterized, and tested as potential inhibitors or reactivators of acetylcholinesterase (AChE) using the Ellman"s test, nuclear magnetic resonance, and molecular modeling. pralidoxime 11-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 235-239 26558640-4 2016 The most effective AChE inhibitor discovered was the guanylhydrazone derived from 2,4-dinitrobenzaldehyde and was compared with tacrine, displaying similar activity to this reference material. Mitoguazone 53-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 26558640-4 2016 The most effective AChE inhibitor discovered was the guanylhydrazone derived from 2,4-dinitrobenzaldehyde and was compared with tacrine, displaying similar activity to this reference material. 2,4-dinitrobenzaldehyde 82-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 26864149-0 2016 Rosmarinic acid inhibits some metabolic enzymes including glutathione S-transferase, lactoperoxidase, acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase isoenzymes. rosmarinic acid 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 26864149-8 2016 The best inhibitory effect of rosmarinic acid was observed against both AChE and BChE. rosmarinic acid 30-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 26928712-0 2016 Effects of novel acylhydrazones derived from 4-quinolone on the acetylcholinesterase activity and Abeta42 peptide fibrils formation. acylhydrazones 17-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 26928712-0 2016 Effects of novel acylhydrazones derived from 4-quinolone on the acetylcholinesterase activity and Abeta42 peptide fibrils formation. 4-Quinolones 45-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 26928712-4 2016 Except for one acylhydrazone, the compounds exhibited good inhibitory effect on AChE (1.2 muM < IC50 values < 17 muM). acylhydrazone 15-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 26985691-1 2016 A series of carbamate derivatives were synthesized and their carbonic anhydrase I and II isoenzymes and acetylcholinesterase enzyme (AChE) inhibitory effects were investigated. Carbamates 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-131 26985691-1 2016 A series of carbamate derivatives were synthesized and their carbonic anhydrase I and II isoenzymes and acetylcholinesterase enzyme (AChE) inhibitory effects were investigated. Carbamates 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 26985691-3 2016 The carbamates were determined to be very good inhibitors against for AChE and hCA I, and II isoenzymes. Carbamates 4-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 26985691-8 2016 The results clearly showed that AChE and both CA isoenzymes were effectively inhibited by carbamates at the low nanomolar levels. Carbamates 90-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 27050248-6 2016 Also, Tacrine inhibited AChE and BChE showed Ki values of 396.03 and 209.21 nM, respectively. Tacrine 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 27718143-11 2017 Based on these data, it is plausible to predict that donepezil might produce a stronger AChE inhibition in the brain at 24 h compared with 12 h following the administration. Donepezil 53-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 28066242-1 2016 Donepezil, an acetylcholinesterase inhibitor, induces only moderate symptomatic effects on memory in Alzheimer"s disease patients. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 28263539-0 2016 Celecoxib is an inhibitor of enzyme acetylcholinesterase. Celecoxib 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 28263539-3 2016 In the work presented here, affinity of celecoxib to enzyme acetylcholinesterase (AChE) is inferred. Celecoxib 40-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 28263539-3 2016 In the work presented here, affinity of celecoxib to enzyme acetylcholinesterase (AChE) is inferred. Celecoxib 40-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 28263539-4 2016 METHODS: Inhibition of human AChE by celecoxib was tested using standard spectrophotometric Ellman s method and extrapolation of experimental data by Dixon plot. Celecoxib 37-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 28263539-5 2016 Interaction between AChE and celecoxib was also predicted by molecular docking using Swiss dock software. Celecoxib 29-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 27977009-9 2016 The AChE potentially negates the cholinergic anti-inflammatory signal by hydrolyzing the acetylcholine. Acetylcholine 89-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 27910192-1 2016 In order to develop effective anti-cholinesterase compounds, a novel series of pyrano[3",4":5,6]pyrano[2,3-b]quinolinones were designed, synthesized, and evaluated in vitro against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). pyrano[3",4":5,6]pyrano[2,3-b]quinolinones 79-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-201 27910192-1 2016 In order to develop effective anti-cholinesterase compounds, a novel series of pyrano[3",4":5,6]pyrano[2,3-b]quinolinones were designed, synthesized, and evaluated in vitro against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). pyrano[3",4":5,6]pyrano[2,3-b]quinolinones 79-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 203-207 27910192-6 2016 Also, kinetic and molecular docking studies of binding interactions elucidated that compound 6f bound to both the catalytic anionic site (CAS) and peripheral anionic site (PAS) of AChE. Aminosalicylic Acid 172-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 27668538-8 2016 Our findings revealed that ethanol extract exhibited inhibitory activity against JNK3 and AChE. Ethanol 27-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 27072944-3 2016 There is no report that advanced SSc with severe gastroesophageal reflux disease (GERD) is successfully treated with acotiamide, which is the acetylcholinesterase (AChE) inhibitor designed for functional dyspepsia (FD). Z 338 117-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 27072944-3 2016 There is no report that advanced SSc with severe gastroesophageal reflux disease (GERD) is successfully treated with acotiamide, which is the acetylcholinesterase (AChE) inhibitor designed for functional dyspepsia (FD). Z 338 117-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 27916909-4 2016 We demonstrated that lower ACh levels in serum of RR-MS patients were inversely correlated with the increased activity of the hydrolyzing enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Acetylcholine 27-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-166 27916909-4 2016 We demonstrated that lower ACh levels in serum of RR-MS patients were inversely correlated with the increased activity of the hydrolyzing enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Acetylcholine 27-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-172 27783974-1 2016 Donepezil (DNP), an acetylcholinesterase (AChE) inhibitor, is one of the most preferred choices in Alzheimer diseases (AD) therapy. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 27783974-1 2016 Donepezil (DNP), an acetylcholinesterase (AChE) inhibitor, is one of the most preferred choices in Alzheimer diseases (AD) therapy. Donepezil 11-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 27592396-0 2016 New piperidine-hydrazone derivatives: Synthesis, biological evaluations and molecular docking studies as AChE and BChE inhibitors. piperidine-hydrazone 4-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 27062893-0 2016 Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents. Oximes 30-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 27062893-0 2016 Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents. organophosphorus 86-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 27062893-1 2016 Currently fielded treatments for nerve agent intoxication include atropine, an acetylcholine receptor antagonist, and pralidoxime (2PAM), a small molecule reactivator of acetylcholinesterase (AChE). pralidoxime 118-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-190 27062893-1 2016 Currently fielded treatments for nerve agent intoxication include atropine, an acetylcholine receptor antagonist, and pralidoxime (2PAM), a small molecule reactivator of acetylcholinesterase (AChE). pralidoxime 118-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 27062893-2 2016 2PAM reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Oximes 82-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 27062893-2 2016 2PAM reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Phosphorus 102-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 27083142-6 2016 Acetylcholinesterase participates in the regulation of cell proliferation and apoptosis through hydrolysis of acetylcholine and by other catalytic and non catalytic mechanisms, in a variant-specific manner. Acetylcholine 110-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 27109753-2 2016 Because of the central role of acetylcholinesterase cholinergic neurotransmission in humans, one of the main purposes for using OPs is inactivation of the enzyme by phosphorylation of the nucleophilic serine residue in the active center. Serine 201-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 27125761-2 2016 The need for an effective treatment of OP poisoning resulted in the implementation of a combination therapy with the muscarinic receptor antagonist atropine and an oxime for the reactivation of OP-inhibited acetylcholinesterase (AChE). Atropine 148-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 229-233 27125761-2 2016 The need for an effective treatment of OP poisoning resulted in the implementation of a combination therapy with the muscarinic receptor antagonist atropine and an oxime for the reactivation of OP-inhibited acetylcholinesterase (AChE). Oximes 164-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 229-233 27125761-6 2016 Multiple in vitro and in vivo studies investigated the potential of oximes to reactivate OP-inhibited AChE and to reverse OP-induced cholinergic signs. Oximes 68-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 27138243-0 2016 Synthesis and in-vitro reactivation screening of imidazolium aldoximes as reactivators of sarin and VX-inhibited human acetylcholinesterase (hAChE). imidazolium 49-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-146 27138243-3 2016 A series of structurally related 1,3-disubstituted-2-[(hydroxyiminomethyl)alkyl]imidazolium halides (5a-5e, 9a-9c) were synthesized and further evaluated for their in-vitro reactivation ability to reactivate sarin- and VX-inhibited human acetylcholinesterase (hAChE). 1,3-disubstituted-2-[(hydroxyiminomethyl)alkyl]imidazolium halides 33-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 260-265 27238725-1 2016 Within this study, we designed and synthesized four new oxime compounds of the N-substituted 2-hydroxyiminoacetamide structure and evaluated their interactions with acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Oximes 56-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-185 27238725-1 2016 Within this study, we designed and synthesized four new oxime compounds of the N-substituted 2-hydroxyiminoacetamide structure and evaluated their interactions with acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Oximes 56-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 27238725-1 2016 Within this study, we designed and synthesized four new oxime compounds of the N-substituted 2-hydroxyiminoacetamide structure and evaluated their interactions with acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). n-substituted 2-hydroxyiminoacetamide 79-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-185 27238725-1 2016 Within this study, we designed and synthesized four new oxime compounds of the N-substituted 2-hydroxyiminoacetamide structure and evaluated their interactions with acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). n-substituted 2-hydroxyiminoacetamide 79-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 27238725-5 2016 The new compounds 1-4 differed in their presumed AChE peripheral site binding moiety, which ranged from an azide group to functionalized heterocycles. Azides 107-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 27238725-9 2016 Compounds were screened for reactivation of cyclosarin-, sarin- and VX-inhibited AChE and BChE. cyclohexyl methylphosphonofluoridate 44-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 27256520-4 2016 Pesticide poisonings present a special therapeutic challenge since in many cases, such as with parathion, their toxicity stems from their metabolites that inhibit the essential enzyme acetylcholinesterase. Parathion 95-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-204 27374124-0 2016 New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins. Dioxins 81-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 27374124-1 2016 Acetylcholinesterase (AChE; EC 3.1.1.7) is a vital functional enzyme in cholinergic neurotransmission which can rapidly hydrolyze neurotransmitter, acetylcholine, in the central and peripheral nervous systems. Acetylcholine 148-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 27374124-1 2016 Acetylcholinesterase (AChE; EC 3.1.1.7) is a vital functional enzyme in cholinergic neurotransmission which can rapidly hydrolyze neurotransmitter, acetylcholine, in the central and peripheral nervous systems. Acetylcholine 148-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 27374124-2 2016 Emerging evidence showed that in addition to classical environmental AChE inhibitors, e.g. organophosphate and carbamate pesticides, dioxins are a new type of xenobiotic causing impairment of AChE. Dioxins 133-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 27374124-2 2016 Emerging evidence showed that in addition to classical environmental AChE inhibitors, e.g. organophosphate and carbamate pesticides, dioxins are a new type of xenobiotic causing impairment of AChE. Dioxins 133-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 27374124-3 2016 Dioxin can transcriptionally or post-transcriptionally suppress AChE expression in human neuroblastoma cells or mouse immune cells via the aryl hydrocarbon receptor (AhR) pathway, respectively. Dioxins 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 27374124-5 2016 Therefore, in this review, by summarizing the known mechanisms of AChE regulation and dioxin-induced gene alteration, potential signaling cascades and epigenetic mechanisms are proposed for dioxin-mediated AChE regulation. Dioxins 86-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 206-210 27374124-5 2016 Therefore, in this review, by summarizing the known mechanisms of AChE regulation and dioxin-induced gene alteration, potential signaling cascades and epigenetic mechanisms are proposed for dioxin-mediated AChE regulation. Dioxins 190-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 27374124-5 2016 Therefore, in this review, by summarizing the known mechanisms of AChE regulation and dioxin-induced gene alteration, potential signaling cascades and epigenetic mechanisms are proposed for dioxin-mediated AChE regulation. Dioxins 190-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 206-210 27551891-1 2016 The organophosphate O-(2-fluoroethyl)-O-(p-nitrophenyl) methyphosphonate 1 is the first-in-class, fluorine-18 radiolabeled organophosphate inhibitor ([18F]1) of acetylcholinesterase (AChE). organophosphate o-(2-fluoroethyl)-o-(p-nitrophenyl) methyphosphonate 4-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-181 26612005-1 2016 In the present work, we performed docking and molecular dynamics simulations studies on two groups of long-tailored oximes designed as peripheral site binders of acetylcholinesterase (AChE) and potential penetrators on the blood brain barrier. Oximes 116-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-188 27551891-1 2016 The organophosphate O-(2-fluoroethyl)-O-(p-nitrophenyl) methyphosphonate 1 is the first-in-class, fluorine-18 radiolabeled organophosphate inhibitor ([18F]1) of acetylcholinesterase (AChE). organophosphate o-(2-fluoroethyl)-o-(p-nitrophenyl) methyphosphonate 4-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-187 27551891-1 2016 The organophosphate O-(2-fluoroethyl)-O-(p-nitrophenyl) methyphosphonate 1 is the first-in-class, fluorine-18 radiolabeled organophosphate inhibitor ([18F]1) of acetylcholinesterase (AChE). Organophosphates 4-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-181 27551891-1 2016 The organophosphate O-(2-fluoroethyl)-O-(p-nitrophenyl) methyphosphonate 1 is the first-in-class, fluorine-18 radiolabeled organophosphate inhibitor ([18F]1) of acetylcholinesterase (AChE). Organophosphates 4-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-187 27208478-2 2016 In this study, we developed a novel colorimetric assay for the detection of OPs based on polyacrylic acid-coated cerium oxide nanoparticles (PAA-CeO2) as an oxidase mimic and OPs as inhibitors to suppress the activity of acetylcholinesterase (AChE). carbopol 940 89-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 221-241 27693733-1 2016 Organophosphorus (OP) nerve agents (sarin, tabun VX and soman) inhibit the enzyme acetylcholinesterase (AChE, EC 3.1.1.7) by binding to its active site while preventing neurotransmission in the cholinergic synapses. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 27693733-1 2016 Organophosphorus (OP) nerve agents (sarin, tabun VX and soman) inhibit the enzyme acetylcholinesterase (AChE, EC 3.1.1.7) by binding to its active site while preventing neurotransmission in the cholinergic synapses. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 27693733-3 2016 To aid the search for more efficient antidotes, we evaluated the ability of nine pyridoxal oxime derivatives, prepared by a novel synthetic pathway, to reactivate recombinant human AChE and the related purified human plasma butyrylcholinesterase (BChE, EC 3.1.1.8) inhibited by VX, tabun and paraoxon. pyridoxaloxime 81-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 27693733-7 2016 The cholinesterases displayed a binding affinity for these derivatives in a mumolar range no matter the substituent on their rings which was in accordance with the molecular modelling results showing a similar binding pattern for all oximes within the active site of both AChE and BChE. Oximes 234-240 acetylcholinesterase (Cartwright blood group) Homo sapiens 272-276 27208478-2 2016 In this study, we developed a novel colorimetric assay for the detection of OPs based on polyacrylic acid-coated cerium oxide nanoparticles (PAA-CeO2) as an oxidase mimic and OPs as inhibitors to suppress the activity of acetylcholinesterase (AChE). carbopol 940 89-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 243-247 27681239-6 2016 In addition, they showed acetylcholinesterase inhibition activity and some of them presented activity superior to that of the standard drug galantamine. Galantamine 140-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 27687968-0 2016 A facile stereoselective synthesis of dispiro-indeno pyrrolidine/pyrrolothiazole-thiochroman hybrids and evaluation of their antimycobacterial, anticancer and AchE inhibitory activities. dispiro-indeno pyrrolidine 38-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 27687968-0 2016 A facile stereoselective synthesis of dispiro-indeno pyrrolidine/pyrrolothiazole-thiochroman hybrids and evaluation of their antimycobacterial, anticancer and AchE inhibitory activities. 2H-PYRROLO[2,3-D]THIAZOLE 65-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 27687968-0 2016 A facile stereoselective synthesis of dispiro-indeno pyrrolidine/pyrrolothiazole-thiochroman hybrids and evaluation of their antimycobacterial, anticancer and AchE inhibitory activities. Thiochroman 81-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 27484515-0 2016 Synthesis and structure-activity relationship study of tacrine-based pyrano[2,3-c]pyrazoles targeting AChE/BuChE and 15-LOX. tacrine-based pyrano[2,3-c]pyrazoles 55-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 27484515-1 2016 A series of tacrine-based pyrazolo[4",3":5,6]pyrano[2,3-b]quinolines and related compounds were designed and synthesized for targeting AChE, BuChE and 15-LOX enzymes in the field of Alzheimer"s disease therapy. tacrine-based pyrazolo[4",3":5,6]pyrano[2,3-b]quinolines 12-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 27484515-3 2016 In particular, compounds 29, 32 and 40 displayed inhibition at nano-molar level against AChE and BuChE (IC50s = 0.005-0.08 muM), being more potent than reference drug tacrine. Tacrine 167-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 27754682-0 2016 Acetylcholinesterase-Capped Mesoporous Silica Nanoparticles That Open in the Presence of Diisopropylfluorophosphate (a Sarin or Soman Simulant). Silicon Dioxide 39-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 27754682-0 2016 Acetylcholinesterase-Capped Mesoporous Silica Nanoparticles That Open in the Presence of Diisopropylfluorophosphate (a Sarin or Soman Simulant). Isoflurophate 89-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 27754682-1 2016 Mesoporous silica nanoparticles loaded with rhodamine B and capped with acetylcholinesterase are able to be selectively opened and deliver their cargo in the presence of nerve agent simulant diisopropyl fluorophosphate (DFP). Silicon Dioxide 11-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 27754682-1 2016 Mesoporous silica nanoparticles loaded with rhodamine B and capped with acetylcholinesterase are able to be selectively opened and deliver their cargo in the presence of nerve agent simulant diisopropyl fluorophosphate (DFP). Isoflurophate 191-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 27754682-1 2016 Mesoporous silica nanoparticles loaded with rhodamine B and capped with acetylcholinesterase are able to be selectively opened and deliver their cargo in the presence of nerve agent simulant diisopropyl fluorophosphate (DFP). Isoflurophate 220-223 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 27442715-4 2016 Prior studies have shown that donepezil, an acetylcholinesterase inhibitor, might improve OSA, but the mechanism is unknown. Donepezil 30-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 27208478-4 2016 And the enzyme of AChE was used to catalyze the substrate of acetylthiocholine (ATCh) to produce thiocholine (TCh). Acetylthiocholine 61-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 27208478-4 2016 And the enzyme of AChE was used to catalyze the substrate of acetylthiocholine (ATCh) to produce thiocholine (TCh). Acetylthiocholine 80-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 27208478-4 2016 And the enzyme of AChE was used to catalyze the substrate of acetylthiocholine (ATCh) to produce thiocholine (TCh). Thiocholine 67-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 27208478-4 2016 And the enzyme of AChE was used to catalyze the substrate of acetylthiocholine (ATCh) to produce thiocholine (TCh). Thiocholine 81-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 27208478-6 2016 Upon incubated with OPs, the enzymatic activity of AChE was inhibited to produce less TCh, resulting in more TMB catalytically oxidized by PAA-CeO2 to show an increasing blue color. Thiocholine 86-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 27208478-6 2016 Upon incubated with OPs, the enzymatic activity of AChE was inhibited to produce less TCh, resulting in more TMB catalytically oxidized by PAA-CeO2 to show an increasing blue color. 3,3',5,5'-tetramethylbenzidine 109-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 27229445-2 2016 On-line HPLC-photo-diode array-fluorescence detection based on the fluorogenic substrate 7-acetoxy-1-methyl quinolinium iodide, was built to search acetylcholinesterase (AChE) inhibitors in Danshen injection. 7-acetoxy-1-methyl quinolinium iodide 89-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-168 27229445-2 2016 On-line HPLC-photo-diode array-fluorescence detection based on the fluorogenic substrate 7-acetoxy-1-methyl quinolinium iodide, was built to search acetylcholinesterase (AChE) inhibitors in Danshen injection. 7-acetoxy-1-methyl quinolinium iodide 89-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 27775608-0 2016 Discovery of Potent Carbonic Anhydrase and Acetylcholinesterase Inhibitors: 2-Aminoindan beta-Lactam Derivatives. 2-aminoindan beta-lactam 76-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 27637382-3 2016 Various fluorinated acetophenone derivatives bind to acetylcholinesterase with high affinity, including 2,2,2-trifluoro-1-(3-dimethylaminophenyl)ethanone (1) and 1-(3-tert-butylphenyl)-2,2,2-trifluoroethanone (2). acetophenone 20-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 27637382-3 2016 Various fluorinated acetophenone derivatives bind to acetylcholinesterase with high affinity, including 2,2,2-trifluoro-1-(3-dimethylaminophenyl)ethanone (1) and 1-(3-tert-butylphenyl)-2,2,2-trifluoroethanone (2). 2,2,2-trifluoro-1-(3-dimethylaminophenyl)ethanone 104-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 27637382-3 2016 Various fluorinated acetophenone derivatives bind to acetylcholinesterase with high affinity, including 2,2,2-trifluoro-1-(3-dimethylaminophenyl)ethanone (1) and 1-(3-tert-butylphenyl)-2,2,2-trifluoroethanone (2). CHEMBL89354 162-208 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 27282589-2 2016 Compound 8e (N-(3,4-dimethoxybenzyl)-1,2,3,4-tetrahydroacridin-9-amine) was identified as a potent inhibitor of butyrylcholinesterase (BuChE IC50 = 20 nm; AChE IC50 = 2.2 mum) and was able to inhibit amyloid aggregation (40% inhibition at 25 mum). 8e 9-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-160 27282589-2 2016 Compound 8e (N-(3,4-dimethoxybenzyl)-1,2,3,4-tetrahydroacridin-9-amine) was identified as a potent inhibitor of butyrylcholinesterase (BuChE IC50 = 20 nm; AChE IC50 = 2.2 mum) and was able to inhibit amyloid aggregation (40% inhibition at 25 mum). n-(3,4-dimethoxybenzyl)-1,2,3,4-tetrahydroacridin-9-amine 13-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-160 27282589-4 2016 The picolylamine-substituted compound 12c (6-chloro-N-(pyridin-2-ylmethyl)-1,2,3,4-tetrahydroacridin-9-amine) was the most potent AChE inhibitor (IC50 = 90 nm). (Fe(2-picolylamine)(3))(2 ) 4-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 27282589-4 2016 The picolylamine-substituted compound 12c (6-chloro-N-(pyridin-2-ylmethyl)-1,2,3,4-tetrahydroacridin-9-amine) was the most potent AChE inhibitor (IC50 = 90 nm). 12c 38-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 27282589-4 2016 The picolylamine-substituted compound 12c (6-chloro-N-(pyridin-2-ylmethyl)-1,2,3,4-tetrahydroacridin-9-amine) was the most potent AChE inhibitor (IC50 = 90 nm). 6-chloro-n-(pyridin-2-ylmethyl)-1,2,3,4-tetrahydroacridin-9-amine 43-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 27705071-1 2016 Sarin (GB, O-isopropyl methylphosphonofluoridate) is a potent organophosphorus (OP) nerve agent that inhibits acetylcholinesterase (AChE) irreversibly. Sarin 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 27705071-1 2016 Sarin (GB, O-isopropyl methylphosphonofluoridate) is a potent organophosphorus (OP) nerve agent that inhibits acetylcholinesterase (AChE) irreversibly. Sarin 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 27705071-1 2016 Sarin (GB, O-isopropyl methylphosphonofluoridate) is a potent organophosphorus (OP) nerve agent that inhibits acetylcholinesterase (AChE) irreversibly. Sarin 11-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 27705071-1 2016 Sarin (GB, O-isopropyl methylphosphonofluoridate) is a potent organophosphorus (OP) nerve agent that inhibits acetylcholinesterase (AChE) irreversibly. Sarin 11-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 27705071-1 2016 Sarin (GB, O-isopropyl methylphosphonofluoridate) is a potent organophosphorus (OP) nerve agent that inhibits acetylcholinesterase (AChE) irreversibly. organophosphorus 62-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 27705071-1 2016 Sarin (GB, O-isopropyl methylphosphonofluoridate) is a potent organophosphorus (OP) nerve agent that inhibits acetylcholinesterase (AChE) irreversibly. organophosphorus 62-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 27796833-9 2016 Induction of AChE activity was observed in formaldehyde-exposed workers as compared with the control group (p < 0.01), while AChE activity increased in 64 % of the exposed subjects. Formaldehyde 43-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 27796833-10 2016 Spearman"s correlation (p < 0.02) was used to evaluate the association between AChE activity and occupational exposure to formaldehyde. Formaldehyde 125-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 27796833-12 2016 The findings of this study suggest that the neurotoxic effect of formaldehyde depends on the AChE activity, which is affected by metabolism. Formaldehyde 65-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 27376495-0 2016 Avarol derivatives as competitive AChE inhibitors, non hepatotoxic and neuroprotective agents for Alzheimer"s disease. avarol 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 27376495-2 2016 Recent findings indicate that some thio-avarol derivatives exhibit acetylcholinesterase (AChE) inhibitory activity. thio-avarol 35-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 27376495-2 2016 Recent findings indicate that some thio-avarol derivatives exhibit acetylcholinesterase (AChE) inhibitory activity. thio-avarol 35-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 27376495-7 2016 Among them, TPH4, bearing a geranylgeraniol substituent, is the most significant Electrophorus electricus AChE (EeAChE) inhibitor (IC50 = 6.77 +- 0.24 muM), also endowed with a moderate serum horse butyrylcholinesterase (eqBuChE) inhibitory activity, being also the least hepatotoxic and the best neuroprotective compound of the series. tph4 12-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 27376495-9 2016 Findings prove the relevance of TPHs as a new possible generation of competitive AChE inhibitors pointing out the importance of the salycilic substituents on the hydroquinone ring. hydroquinone 162-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 27505087-0 2016 Biological evaluation and docking studies of some benzoxazole derivatives as inhibitors of acetylcholinesterase and butyrylcholinesterase. Benzoxazoles 50-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 27505087-1 2016 A series of 2,5-disubstituted-benzoxazole derivatives (1-13) were evaluated as possible inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). 2,5-disubstituted-benzoxazole 12-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 27505087-1 2016 A series of 2,5-disubstituted-benzoxazole derivatives (1-13) were evaluated as possible inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). 2,5-disubstituted-benzoxazole 12-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 27505087-3 2016 Another derivative displayed a similar activity to that of reference drug (galanthamine) for inhibition of AChE and BChE. Galantamine 75-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 27775608-4 2016 The results reveal that beta-lactams are inhibitors of hCA I, II and AChE. beta-Lactams 24-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 27775608-5 2016 The Ki values of beta-lactams (2a-k) were 0.44-6.29 nM against hCA I, 0.93-8.34 nM against hCA II, and 0.25-1.13 nM against AChE. beta-Lactams 17-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 27775608-6 2016 Our findings indicate that beta-lactams (2a-k) inhibit both carbonic anhydrases (CA) isoenzymes and AChE at low nanomolar concentrations. beta-Lactams 27-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 27568232-0 2016 The dual-acting AChE inhibitor and H3 receptor antagonist UW-MD-72 reverses amnesia induced by scopolamine or dizocilpine in passive avoidance paradigm in rats. Scopolamine 95-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 27568232-0 2016 The dual-acting AChE inhibitor and H3 receptor antagonist UW-MD-72 reverses amnesia induced by scopolamine or dizocilpine in passive avoidance paradigm in rats. Dizocilpine Maleate 110-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 27568232-1 2016 Both the acetylcholine esterase (AChE) and the histamine H3 receptor (H3R) are involved in the metabolism and modulation of acetylcholine release and numerous other centrally acting neurotransmitters. Acetylcholine 9-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 27392529-3 2016 AChE molecular modeling studies of these hybrids indicated that tacrine moiety interacts in the bottom of the gorge with the catalytic active site (CAS) while tianeptine binds to peripheral anionic site (PAS). Tacrine 64-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 27258202-8 2016 In patients, we found that for higher NO range of values the respiratory function is worse and that for higher AChE range of values the RBCs nitrite content increase. Nitrites 141-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 27214510-1 2016 A number of N-(2-(1H-indol-3-yl)ethyl)-2-oxo-2H-chromene-3-carboxamides were synthesized and tested against AChE and BuChE. n-(2-(1h-indol-3-yl)ethyl)-2-oxo-2h-chromene-3-carboxamides 12-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 27392529-3 2016 AChE molecular modeling studies of these hybrids indicated that tacrine moiety interacts in the bottom of the gorge with the catalytic active site (CAS) while tianeptine binds to peripheral anionic site (PAS). cas 148-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 27214510-3 2016 The SAR study demonstrated that the introduction of benzyloxy moiety on the 7-position of coumarin scaffold can improve the anti-AChE activity. coumarin 90-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 27392529-3 2016 AChE molecular modeling studies of these hybrids indicated that tacrine moiety interacts in the bottom of the gorge with the catalytic active site (CAS) while tianeptine binds to peripheral anionic site (PAS). tianeptine 159-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 27214510-5 2016 Based on the docking study of AChE, the prototype compound 4o was laid across the active site and occupied both peripheral anionic site (PAS) and catalytic anionic site (CAS). Aminosalicylic Acid 137-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 27214510-5 2016 Based on the docking study of AChE, the prototype compound 4o was laid across the active site and occupied both peripheral anionic site (PAS) and catalytic anionic site (CAS). cas 170-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 27392529-3 2016 AChE molecular modeling studies of these hybrids indicated that tacrine moiety interacts in the bottom of the gorge with the catalytic active site (CAS) while tianeptine binds to peripheral anionic site (PAS). Aminosalicylic Acid 204-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 27604478-2 2016 As anticipated by the initial properties of huprine, both probes displayed a high affinity and selectivity for AChE toward BChE, with IC50 values in the nanomolar range and without any non-specific binding in the tissues. huprine 44-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 27604478-4 2016 Moreover, the binding of HupNIR2 is affected when AChE is inhibited with toxic molecules such as organophosphates. Organophosphates 97-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 26022447-10 2016 Of these five patients, one patient took the acetylcholinesterase inhibitor drug donepezil. Donepezil 81-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 27698319-1 2016 Crystallization of tacrine hydrochloride, an acetylcholinesterase inhibitor used during treatment of mild to moderate Alzheimer"s disease, from a water:ethanol solution has resulted in an orthorhombic pseudopolymorph. Tacrine 19-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 27251198-6 2016 Owing to the capability of organophosphorus pesticides to inhibit AChE, this biosensor was used to detect these pollutants, and paraoxon was taken as model compound. organophosphorus 27-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 27251198-3 2016 The possibility to detect thiocholine at a low applied potential with high sensitivity was exploited and an acetylcholinesterase (AChE) biosensor was developed. Thiocholine 26-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 27251198-3 2016 The possibility to detect thiocholine at a low applied potential with high sensitivity was exploited and an acetylcholinesterase (AChE) biosensor was developed. Thiocholine 26-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 27251198-5 2016 The enzymatic activity of the immobilized AChE was determined measuring the enzymatic product thiocholine at +300 mV. Thiocholine 94-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 27441832-0 2016 Synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory potential of hydrazide based Schiff bases. Isoniazid 94-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 27441832-0 2016 Synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory potential of hydrazide based Schiff bases. Schiff Bases 110-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 27441832-2 2016 We have synthesized twenty-eight analogs of hydrazide based Schiff bases, characterized by various spectroscopic techniques and evaluated in vitro for acetylcholinesterase and butyrylcholinesterase inhibition. Isoniazid 44-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-171 27519464-4 2016 Among all the synthesized compounds (15a-i, 16a-d, 17a-b), compound 15a [4-[3-(4-phenylpiperazin-1-yl)propoxy]-2H-chromen-2-one] displayed significant antiamnesic activity, AChE inhibitory activity (IC50=2.42muM) and antioxidant activity in comparison to donepezil (IC50=1.82muM). 4-[3-(4-phenylpiperazin-1-yl)propoxy]-2h-chromen-2-one 73-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-177 27398906-6 2016 Perimidine molecule displayed promising inhibitory activity against acetylcholinesterase (AChE) as compared to the reference drug, tacrine. perimidine 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 27398906-6 2016 Perimidine molecule displayed promising inhibitory activity against acetylcholinesterase (AChE) as compared to the reference drug, tacrine. perimidine 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 27398906-6 2016 Perimidine molecule displayed promising inhibitory activity against acetylcholinesterase (AChE) as compared to the reference drug, tacrine. Tacrine 131-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 27398906-6 2016 Perimidine molecule displayed promising inhibitory activity against acetylcholinesterase (AChE) as compared to the reference drug, tacrine. Tacrine 131-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 27459153-2 2016 AChEIs reversibly inhibit acetylcholinesterase (AChE), thus increasing the availability of acetylcholine in cholinergic synapses, enhancing cholinergic transmission. Acetylcholine 26-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 27698745-9 2016 The patient was treated with oral potassium supplementation and an acetylcholinesterase inhibitor (pyridostigmine), after which the symptoms were improved. Pyridostigmine Bromide 99-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 27235273-0 2016 Tacrine-(hydroxybenzoyl-pyridone) hybrids as potential multifunctional anti-Alzheimer"s agents: AChE inhibition, antioxidant activity and metal chelating capacity. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 27235273-0 2016 Tacrine-(hydroxybenzoyl-pyridone) hybrids as potential multifunctional anti-Alzheimer"s agents: AChE inhibition, antioxidant activity and metal chelating capacity. (hydroxybenzoyl-pyridone 8-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 27235273-1 2016 Three novel potentially site-activated multitarget tacrine-(hydroxybenzoyl-pyridone) (TAC-HBP) hybrids were designed, synthesized and evaluated as acetylcholinesterase (AChE) inhibitors, antioxidants and biometal chelators. Tacrine 51-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 27235273-1 2016 Three novel potentially site-activated multitarget tacrine-(hydroxybenzoyl-pyridone) (TAC-HBP) hybrids were designed, synthesized and evaluated as acetylcholinesterase (AChE) inhibitors, antioxidants and biometal chelators. Tacrine 51-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 27235273-1 2016 Three novel potentially site-activated multitarget tacrine-(hydroxybenzoyl-pyridone) (TAC-HBP) hybrids were designed, synthesized and evaluated as acetylcholinesterase (AChE) inhibitors, antioxidants and biometal chelators. (hydroxybenzoyl-pyridone 59-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 27235273-1 2016 Three novel potentially site-activated multitarget tacrine-(hydroxybenzoyl-pyridone) (TAC-HBP) hybrids were designed, synthesized and evaluated as acetylcholinesterase (AChE) inhibitors, antioxidants and biometal chelators. tac 86-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 27235273-1 2016 Three novel potentially site-activated multitarget tacrine-(hydroxybenzoyl-pyridone) (TAC-HBP) hybrids were designed, synthesized and evaluated as acetylcholinesterase (AChE) inhibitors, antioxidants and biometal chelators. tac 86-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 27235273-1 2016 Three novel potentially site-activated multitarget tacrine-(hydroxybenzoyl-pyridone) (TAC-HBP) hybrids were designed, synthesized and evaluated as acetylcholinesterase (AChE) inhibitors, antioxidants and biometal chelators. hbp 90-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 27235273-1 2016 Three novel potentially site-activated multitarget tacrine-(hydroxybenzoyl-pyridone) (TAC-HBP) hybrids were designed, synthesized and evaluated as acetylcholinesterase (AChE) inhibitors, antioxidants and biometal chelators. hbp 90-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 27235273-2 2016 All of them are dual-binding site AChE inhibitors with activity in sub-micromolar range (IC50=0.57-0.78muM), which is comparable to the parent tacrine, and have good 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity (EC50=204-249muM) conferred by the hydroxybenzoyl-pyridone (HBP) moiety. Tacrine 143-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 27235273-2 2016 All of them are dual-binding site AChE inhibitors with activity in sub-micromolar range (IC50=0.57-0.78muM), which is comparable to the parent tacrine, and have good 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity (EC50=204-249muM) conferred by the hydroxybenzoyl-pyridone (HBP) moiety. 1,1-diphenyl-2-picrylhydrazyl 166-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 27235273-2 2016 All of them are dual-binding site AChE inhibitors with activity in sub-micromolar range (IC50=0.57-0.78muM), which is comparable to the parent tacrine, and have good 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity (EC50=204-249muM) conferred by the hydroxybenzoyl-pyridone (HBP) moiety. 1,1-diphenyl-2-picrylhydrazyl 197-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 27235273-2 2016 All of them are dual-binding site AChE inhibitors with activity in sub-micromolar range (IC50=0.57-0.78muM), which is comparable to the parent tacrine, and have good 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity (EC50=204-249muM) conferred by the hydroxybenzoyl-pyridone (HBP) moiety. hydroxybenzoyl-pyridone 266-289 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 27235273-2 2016 All of them are dual-binding site AChE inhibitors with activity in sub-micromolar range (IC50=0.57-0.78muM), which is comparable to the parent tacrine, and have good 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity (EC50=204-249muM) conferred by the hydroxybenzoyl-pyridone (HBP) moiety. hbp 291-294 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 30549626-2 2016 Among the many Amaryllidaceae compounds, galanthamine has been given a great amount of attention due to the fact that it possesses potent acetylcholinesterase inhibitory activity. Galantamine 41-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 27251198-6 2016 Owing to the capability of organophosphorus pesticides to inhibit AChE, this biosensor was used to detect these pollutants, and paraoxon was taken as model compound. Paraoxon 128-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 27251198-10 2016 Graphical Abstract Biosensors based on screen-printed electrodes modified with Acetylcholinesterase, Carbon Black, and Chitosan for organophosphorus pesticide detection. organophosphorus 132-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 27552582-2 2016 Biological activity results demonstrated that compounds 5r and 5t exhibited potent inhibition and excellent selectivity toward acetylcholinesterase (AChE, 5r, IC50 = 0.204 muM, SI > 196; 5t, IC50 = 0.067 muM, SI > 597), specific metal-chelating ability, significant antioxidant effects, modulation of metal-induced Abeta aggregation, inhibition of ROS production by copper redox cycle, low cytotoxicity, and moderate neuroprotection to human neuroblastoma SH-SY5Y cells. Metals 229-234 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 27494215-0 2016 Biological Testing of Organophosphorus-Inactivated Acetylcholinesterase Oxime Reactivators Identified via Virtual Screening. organophosphorus 22-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 27494215-0 2016 Biological Testing of Organophosphorus-Inactivated Acetylcholinesterase Oxime Reactivators Identified via Virtual Screening. Oximes 72-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 27494215-1 2016 There is a pressing need for new therapeutics to reactivate covalently inactivated acetylcholinesterase (AChE) due to exposure to organophosphorus (OP) compounds. organophosphorus 130-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 27494215-1 2016 There is a pressing need for new therapeutics to reactivate covalently inactivated acetylcholinesterase (AChE) due to exposure to organophosphorus (OP) compounds. organophosphorus 130-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 27494215-4 2016 In order to find new starting points for the development of oxime-containing therapeutic reactivators and to increase our base of knowledge, we have employed a combination of computational and experimental procedures to identify additional compounds with the real or potential ability to reactivate AChE while augmenting and complementing current knowledge. Oximes 60-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 299-303 27552582-2 2016 Biological activity results demonstrated that compounds 5r and 5t exhibited potent inhibition and excellent selectivity toward acetylcholinesterase (AChE, 5r, IC50 = 0.204 muM, SI > 196; 5t, IC50 = 0.067 muM, SI > 597), specific metal-chelating ability, significant antioxidant effects, modulation of metal-induced Abeta aggregation, inhibition of ROS production by copper redox cycle, low cytotoxicity, and moderate neuroprotection to human neuroblastoma SH-SY5Y cells. Metals 301-306 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 27552582-2 2016 Biological activity results demonstrated that compounds 5r and 5t exhibited potent inhibition and excellent selectivity toward acetylcholinesterase (AChE, 5r, IC50 = 0.204 muM, SI > 196; 5t, IC50 = 0.067 muM, SI > 597), specific metal-chelating ability, significant antioxidant effects, modulation of metal-induced Abeta aggregation, inhibition of ROS production by copper redox cycle, low cytotoxicity, and moderate neuroprotection to human neuroblastoma SH-SY5Y cells. ros 348-351 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 27494215-6 2016 Experimentally, six compounds were found with reactivation capabilities comparable to, or exceeding, those of 2-pralidoxime (2-PAM) against a panel of AChE inactivated by paraoxon, diisopropylfluorophosphate (DFP), fenamiphos, and methamidophos. 2-pralidoxime 110-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 27494215-6 2016 Experimentally, six compounds were found with reactivation capabilities comparable to, or exceeding, those of 2-pralidoxime (2-PAM) against a panel of AChE inactivated by paraoxon, diisopropylfluorophosphate (DFP), fenamiphos, and methamidophos. Paraoxon 171-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 27494215-6 2016 Experimentally, six compounds were found with reactivation capabilities comparable to, or exceeding, those of 2-pralidoxime (2-PAM) against a panel of AChE inactivated by paraoxon, diisopropylfluorophosphate (DFP), fenamiphos, and methamidophos. Isoflurophate 181-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 27494215-6 2016 Experimentally, six compounds were found with reactivation capabilities comparable to, or exceeding, those of 2-pralidoxime (2-PAM) against a panel of AChE inactivated by paraoxon, diisopropylfluorophosphate (DFP), fenamiphos, and methamidophos. Isoflurophate 209-212 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 27552582-2 2016 Biological activity results demonstrated that compounds 5r and 5t exhibited potent inhibition and excellent selectivity toward acetylcholinesterase (AChE, 5r, IC50 = 0.204 muM, SI > 196; 5t, IC50 = 0.067 muM, SI > 597), specific metal-chelating ability, significant antioxidant effects, modulation of metal-induced Abeta aggregation, inhibition of ROS production by copper redox cycle, low cytotoxicity, and moderate neuroprotection to human neuroblastoma SH-SY5Y cells. Copper 366-372 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 27551784-1 2016 Acetylcholinesterase (AChE) is the physiologically important target for organophosphorus toxicants (OP) including nerve agents and pesticides. organophosphorus 72-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 27551784-1 2016 Acetylcholinesterase (AChE) is the physiologically important target for organophosphorus toxicants (OP) including nerve agents and pesticides. organophosphorus 72-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 27450532-0 2016 Synthesis and in vitro reactivation study of isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as reactivators of Sarin and VX inhibited human acetylcholinesterase (hAChE). isonicotinamide 45-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-194 27450532-6 2016 In comparison to 2-PAM and obidoxime, oxime 4a and 4b exhibited enhanced reactivation efficacy toward sarin inhibited hAChE while oxime 4c showed far greater reactivation efficacy toward VX inhibited hAChE. Oximes 38-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-123 27450532-0 2016 Synthesis and in vitro reactivation study of isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as reactivators of Sarin and VX inhibited human acetylcholinesterase (hAChE). 2-(hydroxyimino)-n-(pyridin-3-yl)acetamide 76-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-194 27450532-1 2016 Previously (Karade et al., 2014), we have reported the synthesis and in vitro evaluation of bis-pyridinium derivatives of pyridine-3-yl-(2-hydroxyimino acetamide), as reactivators of sarin and VX inhibited hAChE. bis-pyridinium 92-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 206-211 27450532-1 2016 Previously (Karade et al., 2014), we have reported the synthesis and in vitro evaluation of bis-pyridinium derivatives of pyridine-3-yl-(2-hydroxyimino acetamide), as reactivators of sarin and VX inhibited hAChE. pyridine-3-yl 122-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 206-211 27450532-1 2016 Previously (Karade et al., 2014), we have reported the synthesis and in vitro evaluation of bis-pyridinium derivatives of pyridine-3-yl-(2-hydroxyimino acetamide), as reactivators of sarin and VX inhibited hAChE. 2-hydroxyimino acetamide 137-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 206-211 27599483-9 2016 Oral administration of 1-phenylisatin has significantly recuperated 2VO induced impairment in learning-memory, increase in TBARS, GSH, CAT, SOD, mitochondrial activity with a significant reduction in AChE activity and brain damage. 1-Phenylisatin 23-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-204 27450532-3 2016 Encouraged by these results, herein we report the synthesis and in vitro evaluation of isonicotinamide derivatives of pyridine-3-yl-(2-hydroxyimino acetamide) (4a-4d) against sarin and VX inhibited erythrocyte ghost hAChE. isonicotinamide 87-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 216-221 27450532-3 2016 Encouraged by these results, herein we report the synthesis and in vitro evaluation of isonicotinamide derivatives of pyridine-3-yl-(2-hydroxyimino acetamide) (4a-4d) against sarin and VX inhibited erythrocyte ghost hAChE. pyridine-3-yl-(2-hydroxyimino acetamide) 118-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 216-221 27424196-6 2016 It has been utilised in combination with TLC- based bioautographic approaches of acetylcholinesterase (AChE) inhibitors, However, it can be also applied in any other procedures related to bioactivity (e.g. 2,2-Diphenyl-1-picryl-hydrazyl-DPPH screen test for radicals). 2,2-diphenyl-1-picryl-hydrazyl-dpph 206-241 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 27424196-6 2016 It has been utilised in combination with TLC- based bioautographic approaches of acetylcholinesterase (AChE) inhibitors, However, it can be also applied in any other procedures related to bioactivity (e.g. 2,2-Diphenyl-1-picryl-hydrazyl-DPPH screen test for radicals). 2,2-diphenyl-1-picryl-hydrazyl-dpph 206-241 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 27695768-0 2016 Profenofos, an Acetylcholinesterase-Inhibiting Organophosphorus Pesticide: A Short Review of Its Usage, Toxicity, and Biodegradation. profenofos 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 27695768-0 2016 Profenofos, an Acetylcholinesterase-Inhibiting Organophosphorus Pesticide: A Short Review of Its Usage, Toxicity, and Biodegradation. organophosphorus 47-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 27506355-12 2016 In addition, we further applied our method to reveal, for the first time, the site-specific N-glycosylation profile of recombinant human acetylcholinesterase expressed in HEK293 cells. Nitrogen 92-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 27191504-0 2016 Structures of paraoxon-inhibited human acetylcholinesterase reveal perturbations of the acyl loop and the dimer interface. Paraoxon 14-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 27191504-1 2016 Irreversible inhibition of the essential nervous system enzyme acetylcholinesterase by organophosphate nerve agents and pesticides may quickly lead to death. Organophosphates 87-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 27191504-3 2016 The current lack of published structural data specific to human acetylcholinesterase organophosphate-inhibited and oxime-bound states hinders development of effective medical treatments. Organophosphates 85-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 27191504-4 2016 We have solved structures of human acetylcholinesterase in different states in complex with the organophosphate insecticide, paraoxon, and oximes. Organophosphates 96-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 27191504-4 2016 We have solved structures of human acetylcholinesterase in different states in complex with the organophosphate insecticide, paraoxon, and oximes. Paraoxon 125-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 27191504-4 2016 We have solved structures of human acetylcholinesterase in different states in complex with the organophosphate insecticide, paraoxon, and oximes. Oximes 139-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 27191504-6 2016 This appears characteristic of acetylcholinesterase inhibition by organophosphate insecticides but not nerve agents. Organophosphates 66-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 27191504-8 2016 Ternary structures of paraoxon-inhibited human acetylcholinesterase in complex with the oximes HI6 and 2-PAM reveals relatively poor positioning for reactivation. Paraoxon 22-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 27191504-8 2016 Ternary structures of paraoxon-inhibited human acetylcholinesterase in complex with the oximes HI6 and 2-PAM reveals relatively poor positioning for reactivation. Oximes 88-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 27191504-8 2016 Ternary structures of paraoxon-inhibited human acetylcholinesterase in complex with the oximes HI6 and 2-PAM reveals relatively poor positioning for reactivation. asoxime chloride 95-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 29924535-3 2016 The new compounds were synthesized from acetylpyridines through five-steps of reaction, and their inhibition activities on AChE were measured in vitro by Ellman method. acetylpyridines 40-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 27426301-0 2016 Synthesis and evaluation of novel 1,2,3-triazole-based acetylcholinesterase inhibitors with neuroprotective activity. Triazoles 34-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 27630569-6 2016 Additionally, ACh produced by T-ALL is not efficiently hydrolyzed, because acetylcholinesterase (AChE) activity is drastically decreased in these cells. Acetylcholine 14-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 27630569-6 2016 Additionally, ACh produced by T-ALL is not efficiently hydrolyzed, because acetylcholinesterase (AChE) activity is drastically decreased in these cells. Acetylcholine 14-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 27597816-6 2016 Acetylcholinesterase (AChE) inhibitors are the drugs preferentially used in AD and that one of these, rivastigmine, is licensed also for PD. Rivastigmine 102-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 27597816-6 2016 Acetylcholinesterase (AChE) inhibitors are the drugs preferentially used in AD and that one of these, rivastigmine, is licensed also for PD. Rivastigmine 102-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 26374551-3 2016 The present study was designed to investigate whether the increased expression of AChE in central neurons under high glucose (HG) condition was due to activation of mammalian target of rapamycin (mTOR) signaling. Glucose 117-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 27222217-4 2016 To fill this apparent gap, we used electroencephalography (EEG) and a within-subject design in healthy humans who either received the acetylcholinesterase inhibitor galantamine (8mg) or a placebo before they performed a Sternberg WM paradigm. Galantamine 165-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 27260432-0 2016 A sensitive acetylcholinesterase biosensor based on gold nanorods modified electrode for detection of organophosphate pesticide. Organophosphates 102-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 27260432-1 2016 A sensitive amperometric acetylcholinesterase (AChE) biosensor, based on gold nanorods (AuNRs), was developed for the detection of organophosphate pesticide. Organophosphates 131-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 27260432-1 2016 A sensitive amperometric acetylcholinesterase (AChE) biosensor, based on gold nanorods (AuNRs), was developed for the detection of organophosphate pesticide. Organophosphates 131-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 27260432-2 2016 Compared with Au@Ag heterogeneous NRs, AuNRs exhibited excellent electrocatalytic properties, which can electrocatalytically oxidize thiocholine, the hydrolysate of acetylthiocholine chloride (ATCl) by AChE at +0.55V (vs. SCE). Thiocholine 133-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-206 27260432-2 2016 Compared with Au@Ag heterogeneous NRs, AuNRs exhibited excellent electrocatalytic properties, which can electrocatalytically oxidize thiocholine, the hydrolysate of acetylthiocholine chloride (ATCl) by AChE at +0.55V (vs. SCE). Acetylthiocholine chloride 165-191 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-206 27260432-3 2016 The AChE/AuNRs/GCE biosensor was fabricated on basis of the inhibition of AChE activity by organophosphate pesticide. Organophosphates 91-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 27260432-3 2016 The AChE/AuNRs/GCE biosensor was fabricated on basis of the inhibition of AChE activity by organophosphate pesticide. Organophosphates 91-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 27260432-5 2016 The detection limits of paraoxon and dimethoate were 0.7nM and 3.9nM, which were lower than the reported AChE biosensor. Paraoxon 24-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 27260432-5 2016 The detection limits of paraoxon and dimethoate were 0.7nM and 3.9nM, which were lower than the reported AChE biosensor. Dimethoate 37-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 26937779-5 2016 Stability behavior for organophosphates agreed with the proposed reaction mechanism responsible for acetylcholinesterase inhibition. Organophosphates 23-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 27353888-3 2016 Notably, compounds 34 and 38 appeared as most active multifunctional agents in the entire series and exhibited excellent inhibition against AChE (IC50=0.048muM: 34; 0.036muM: 38), Abeta aggregation (max% inhibition 82.2%, IC50=9.2muM: 34; max% inhibition 80.9%, IC50=10.11muM: 38) and displayed significant antioxidant potential in ORAC-FL assay. fluorescein (3',6'-dihydroxyspiro(isobenzofuran-1(3H), 9'(9H)-xanthen)-3-one) 332-339 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 27392137-0 2016 Cocaine cardiovascular effects and pharmacokinetics after treatment with the acetylcholinesterase inhibitor donepezil. Cocaine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 27602288-3 2016 As per the cholinergic hypothesis, the deficiency of choline is responsible for AD; therefore, the inhibition of AChE is a lucrative therapeutic strategy for the treatment of AD. Choline 11-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 27602288-4 2016 Acetylcholinesterase (AChE) is an enzyme that catalyzes the breakdown of the neurotransmitter acetylcholine that is essential for cognition and memory. Acetylcholine 94-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 27602288-4 2016 Acetylcholinesterase (AChE) is an enzyme that catalyzes the breakdown of the neurotransmitter acetylcholine that is essential for cognition and memory. Acetylcholine 94-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 27602288-13 2016 Molecular docking revealed that compounds 13, 5 and 28 exhibited the lowest binding energies of -12.2, -12.0 and -12.0 kcal/mol, respectively, against human AChE, which is modulated by hydrogen bonding, pi-pi stacking and hydrophobic interaction inside the binding pocket. Hydrogen 185-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 27392137-0 2016 Cocaine cardiovascular effects and pharmacokinetics after treatment with the acetylcholinesterase inhibitor donepezil. Donepezil 108-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 27392137-3 2016 Although donepezil is approved for use in patients and selective for inhibiting acetylcholinesterase over BuChE, no studies have reported cocaine bioavailability in human subjects receiving donepezil. Donepezil 9-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 27371941-0 2016 Limitations in current acetylcholinesterase structure-based design of oxime antidotes for organophosphate poisoning. Oximes 70-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 27371941-0 2016 Limitations in current acetylcholinesterase structure-based design of oxime antidotes for organophosphate poisoning. Organophosphates 90-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 27231830-0 2016 Identification of novel acetylcholinesterase inhibitors: Indolopyrazoline derivatives and molecular docking studies. indolopyrazoline 57-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 27231830-1 2016 The synthesis of novel indolopyrazoline derivatives (P1-P4 and Q1-Q4) has been characterized and evaluated as potential anti-Alzheimer agents through in vitro Acetylcholinesterase (AChE) inhibition and radical scavenging activity (antioxidant) studies. indolopyrazoline 23-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 27231830-1 2016 The synthesis of novel indolopyrazoline derivatives (P1-P4 and Q1-Q4) has been characterized and evaluated as potential anti-Alzheimer agents through in vitro Acetylcholinesterase (AChE) inhibition and radical scavenging activity (antioxidant) studies. indolopyrazoline 23-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 27231830-4 2016 Finally, molecular docking studies provided prospective evidence to identify key interactions between the active inhibitors and the AChE that furthermore led us to the identification of plausible binding mode of novel indolopyrazoline derivatives. indolopyrazoline 218-234 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 27087156-2 2016 OPs inhibit acetylcholinesterase (AChE) at nerve endings and accumulate acetylcholine (ACh) at these sites. OPS 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 27087156-2 2016 OPs inhibit acetylcholinesterase (AChE) at nerve endings and accumulate acetylcholine (ACh) at these sites. OPS 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 27087156-2 2016 OPs inhibit acetylcholinesterase (AChE) at nerve endings and accumulate acetylcholine (ACh) at these sites. Acetylcholine 12-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 27087156-2 2016 OPs inhibit acetylcholinesterase (AChE) at nerve endings and accumulate acetylcholine (ACh) at these sites. Acetylcholine 34-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 26186269-2 2016 The results suggested that amino alkyl side chain of chalcone dramatically influenced the inhibitory activity against AChE. Chalcone 53-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 27597816-1 2016 HIGHLIGHTS Compounds that interact with multiple targets but minimally with the cytochrome P450 system (CYP) address the many factors leading to neurodegeneration.Acetyl- and Butyryl-cholineEsterases (AChE, BChE) and Monoamine Oxidases A/B (MAO A, MAO B) are targets for Multi-Target Designed Ligands (MTDL).ASS234 is an irreversible inhibitor of MAO A >MAO B and has micromolar potency against the cholinesterases.ASS234 is a poor CYP substrate in human liver, yielding the depropargylated metabolite.SMe1EC2, a stobadine derivative, showed high radical scavenging property, in vitro and in vivo giving protection in head trauma and diabetic damage of endothelium.Control of mitochondrial function and morphology by manipulating fission and fusion is emerging as a target area for therapeutic strategies to decrease the pathological outcome of neurodegenerative diseases. dicarbine 516-525 acetylcholinesterase (Cartwright blood group) Homo sapiens 201-205 27230386-0 2016 Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer"s disease using multifunctional tacrine-coumarin hybrid molecules. Tacrine 127-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 26114310-1 2016 The acetylcholinesterase inhibitory and/or antitumour activities of amino-, thio- and ester-derivatives of avarol selected were evaluated for the first time at in vitro conditions. amino-, thio- and ester 68-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 26114310-1 2016 The acetylcholinesterase inhibitory and/or antitumour activities of amino-, thio- and ester-derivatives of avarol selected were evaluated for the first time at in vitro conditions. avarol 107-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 26186269-0 2016 Design, synthesis and preliminary structure-activity relationship investigation of nitrogen-containing chalcone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors: a further study based on Flavokawain B Mannich base derivatives. Nitrogen 83-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 26186269-0 2016 Design, synthesis and preliminary structure-activity relationship investigation of nitrogen-containing chalcone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors: a further study based on Flavokawain B Mannich base derivatives. Chalcone 103-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 26186269-1 2016 In order to study the structure-activity relationship of Flavokawain B Mannich-based derivatives as acetylcholinesterase (AChE) inhibitors in our recent investigation, 20 new nitrogen-containing chalcone derivatives (4 a-8d) were designed, synthesized, and evaluated for AChE inhibitory activity in vitro. flavokawain B 57-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 26186269-1 2016 In order to study the structure-activity relationship of Flavokawain B Mannich-based derivatives as acetylcholinesterase (AChE) inhibitors in our recent investigation, 20 new nitrogen-containing chalcone derivatives (4 a-8d) were designed, synthesized, and evaluated for AChE inhibitory activity in vitro. mannich 71-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 27230386-0 2016 Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer"s disease using multifunctional tacrine-coumarin hybrid molecules. coumarin 135-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 27230386-9 2016 Collectively, these results suggest that the design and investigation of multifunctional agents containing along with the acetylcholinesterase inhibitory segment also an antioxidant moiety capable of alleviating metal (copper)-induced oxidative stress, may be of importance in the treatment of Alzheimer"s disease. Metals 212-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 27230386-9 2016 Collectively, these results suggest that the design and investigation of multifunctional agents containing along with the acetylcholinesterase inhibitory segment also an antioxidant moiety capable of alleviating metal (copper)-induced oxidative stress, may be of importance in the treatment of Alzheimer"s disease. Copper 219-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 27295412-0 2016 Potent acetylcholinesterase inhibitors: Synthesis, biological assay and docking study of nitro acridone derivatives. nitro acridone 89-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 7-27 27295412-5 2016 1,7-Dinitroacridone was found to be the most potent AChE inhibitor (IC50=0.22muM). 1,7-dinitroacridone 0-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 27347731-0 2016 Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents. coumarin 38-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 27347731-0 2016 Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents. Water 129-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 27347731-1 2016 Aiming at modulating two key enzymatic targets for Alzheimer"s disease (AD), i.e., acetylcholinesterase (AChE) and monoamine oxidase B (MAO B), a series of multitarget ligands was properly designed by linking the 3,4-dimethylcoumarin scaffold to 1,3- and 1,4-substituted piperidine moieties, thus modulating the basicity to improve the hydrophilic/lipophilic balance. 3,4-DIMETHYL-CHROMEN-2-ONE 213-233 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 27347731-1 2016 Aiming at modulating two key enzymatic targets for Alzheimer"s disease (AD), i.e., acetylcholinesterase (AChE) and monoamine oxidase B (MAO B), a series of multitarget ligands was properly designed by linking the 3,4-dimethylcoumarin scaffold to 1,3- and 1,4-substituted piperidine moieties, thus modulating the basicity to improve the hydrophilic/lipophilic balance. ,4-substituted piperidine 256-281 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 27455222-0 2016 Synthesis, Biological Evaluation and Molecular Modelling of 2"-Hydroxychalcones as Acetylcholinesterase Inhibitors. 2'-hydroxychalcone 60-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 27455222-1 2016 A series of 2"-hydroxy- and 2"-hydroxy-4",6"-dimethoxychalcones was synthesised and evaluated as inhibitors of human acetylcholinesterase (AChE). 2"-hydroxy- and 2"-hydroxy-4",6"-dimethoxychalcones 12-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 27371941-1 2016 Acetylcholinesterase (AChE; EC 3.1.1.7), an essential enzyme of cholinergic neurotransmission in vertebrates, is a primary target in acute nerve agent and organophosphate (OP) pesticide intoxication. Organophosphates 155-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 27309570-0 2016 Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer"s Disease Agents. Fatty Acids 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 27371941-1 2016 Acetylcholinesterase (AChE; EC 3.1.1.7), an essential enzyme of cholinergic neurotransmission in vertebrates, is a primary target in acute nerve agent and organophosphate (OP) pesticide intoxication. Organophosphates 155-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 27371941-2 2016 Catalytically inactive OP-AChE conjugates formed between the active-center serine and phosphorus of OPs can, in principle, be reactivated by nucleophilic oxime antidotes. Serine 75-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 27371941-2 2016 Catalytically inactive OP-AChE conjugates formed between the active-center serine and phosphorus of OPs can, in principle, be reactivated by nucleophilic oxime antidotes. Phosphorus 86-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 27371941-2 2016 Catalytically inactive OP-AChE conjugates formed between the active-center serine and phosphorus of OPs can, in principle, be reactivated by nucleophilic oxime antidotes. Oximes 154-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 27371941-3 2016 Antidote efficacy is limited by the structural diversity of OP-AChE conjugates resulting from differences in the structure of the conjugated OP, the different active-center volumes they occupy when conjugated to the active-center serine of AChE, and the distinct chemical characteristics of both OPs and oximes documented in numerous X-ray structures of OP-conjugated AChEs. Serine 230-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 27371941-3 2016 Antidote efficacy is limited by the structural diversity of OP-AChE conjugates resulting from differences in the structure of the conjugated OP, the different active-center volumes they occupy when conjugated to the active-center serine of AChE, and the distinct chemical characteristics of both OPs and oximes documented in numerous X-ray structures of OP-conjugated AChEs. Serine 230-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 240-244 27371941-3 2016 Antidote efficacy is limited by the structural diversity of OP-AChE conjugates resulting from differences in the structure of the conjugated OP, the different active-center volumes they occupy when conjugated to the active-center serine of AChE, and the distinct chemical characteristics of both OPs and oximes documented in numerous X-ray structures of OP-conjugated AChEs. Oximes 304-310 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 27371941-4 2016 Efforts to improve oxime reactivation efficacy by AChE structure-based enhancement of oxime structure have yielded only limited success. Oximes 19-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 27371941-4 2016 Efforts to improve oxime reactivation efficacy by AChE structure-based enhancement of oxime structure have yielded only limited success. Oximes 86-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 27371941-5 2016 We outline here the potential limitations of available AChE X-ray structures that preclude an accurate prediction of oxime structures, which are necessary for association in the OP-AChE gorge and nucleophilic attack of the OP-conjugated phosphorus. Oximes 117-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 27371941-5 2016 We outline here the potential limitations of available AChE X-ray structures that preclude an accurate prediction of oxime structures, which are necessary for association in the OP-AChE gorge and nucleophilic attack of the OP-conjugated phosphorus. Oximes 117-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 27371941-5 2016 We outline here the potential limitations of available AChE X-ray structures that preclude an accurate prediction of oxime structures, which are necessary for association in the OP-AChE gorge and nucleophilic attack of the OP-conjugated phosphorus. Phosphorus 237-247 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 26921554-0 2016 Choline-induced selective fluorescence quenching of acetylcholinesterase conjugated Au@BSA clusters. Choline 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 26921554-2 2016 The gold quantum clusters (AuQC@BSA) synthesized using bovine serum albumin and conjugated with acetylcholinesterase (AChE), an enzyme specific for acetylcholine, resulting in AuQC@BSA-AChE. Acetylcholine 96-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 26921554-2 2016 The gold quantum clusters (AuQC@BSA) synthesized using bovine serum albumin and conjugated with acetylcholinesterase (AChE), an enzyme specific for acetylcholine, resulting in AuQC@BSA-AChE. Acetylcholine 96-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 185-189 26921554-3 2016 The enzyme, AChE hydrolyzes acetylcholine (ACh) to choline (Ch) which in turn interacts with AuQC@BSA-AChE and quenches its fluorescence, enabling sensing. Acetylcholine 28-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-16 26921554-3 2016 The enzyme, AChE hydrolyzes acetylcholine (ACh) to choline (Ch) which in turn interacts with AuQC@BSA-AChE and quenches its fluorescence, enabling sensing. Acetylcholine 28-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 26921554-3 2016 The enzyme, AChE hydrolyzes acetylcholine (ACh) to choline (Ch) which in turn interacts with AuQC@BSA-AChE and quenches its fluorescence, enabling sensing. Acetylcholine 12-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 26921554-3 2016 The enzyme, AChE hydrolyzes acetylcholine (ACh) to choline (Ch) which in turn interacts with AuQC@BSA-AChE and quenches its fluorescence, enabling sensing. Choline 34-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-16 26921554-3 2016 The enzyme, AChE hydrolyzes acetylcholine (ACh) to choline (Ch) which in turn interacts with AuQC@BSA-AChE and quenches its fluorescence, enabling sensing. Choline 34-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 26921554-7 2016 The fluorescent intensity of AuQC@BSA-AChE is sensitive towards acetylcholine in range of 10nM to 6.4microM. Acetylcholine 64-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 27455222-1 2016 A series of 2"-hydroxy- and 2"-hydroxy-4",6"-dimethoxychalcones was synthesised and evaluated as inhibitors of human acetylcholinesterase (AChE). 2"-hydroxy- and 2"-hydroxy-4",6"-dimethoxychalcones 12-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 27309570-0 2016 Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer"s Disease Agents. Carbamates 140-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 27309570-0 2016 Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer"s Disease Agents. Carbamates 140-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 27441112-0 2016 Identification of 4-aminoquinoline core for the design of new cholinesterase inhibitors. 4-aminoquinoline 18-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-76 27441112-2 2016 Previously we reported compound T5369186 with a core of quinolone as a new cholinesterase inhibitor. t5369186 32-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-89 27441112-2 2016 Previously we reported compound T5369186 with a core of quinolone as a new cholinesterase inhibitor. Quinolones 56-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-89 27441112-4 2016 Based on the results, we confirmed that only 4-aminoquinoline (compound 04 and 07) had cholinesterase inhibitory effects. 4-aminoquinoline 45-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-101 27441112-5 2016 Considering the simple structure and high inhibitory potency against AChE, 4-aminoquinoline provides a good starting core for further designing novel multifunctional AChEIs. 4-aminoquinoline 75-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 27492242-0 2016 Docking-based Design of Galantamine Derivatives with Dual-site Binding to Acetylcholinesterase. Galantamine 24-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 26833890-0 2016 Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer"s Disease. 8-imino-2-oxo-2h,8h-pyrano[2,3-f]chromene 59-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 26833890-4 2016 Among them, 3-bromobenzylamide derivative 4m exhibited the best acetylcholinesterase inhibitory activity with IC50 value of 13 +- 1.4 nm which is 51-fold superior to galantamine, a reference drug. 3-bromobenzylamide 12-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 26833890-4 2016 Among them, 3-bromobenzylamide derivative 4m exhibited the best acetylcholinesterase inhibitory activity with IC50 value of 13 +- 1.4 nm which is 51-fold superior to galantamine, a reference drug. Galantamine 166-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 26833890-8 2016 Overall, these results lead to discovery of fused tricyclic coumarins as promising dual binding site inhibitors of acetylcholinesterase and afford multifunctional compounds with potential impact for further pharmacological development in Alzheimer"s therapy. Coumarins 60-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 27980565-0 2016 Synthesis and Acetylcholinesterase Inhibitory Evaluation of 4-(1,3-Dioxoisoindolin-2-yl)-N-Phenyl Benzamide Derivatives as Potential Anti-Alzheimer Agents. 4-(1,3-dioxoisoindolin-2-yl)-n-phenyl benzamide 60-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 27402296-2 2016 RESULTS: By combining the lipoic acid structure with N-benzylpiperidine or N,N-dibenzyl(N-methyl)amine fragments, new multi-target directed ligands were obtained that act at three relevant targets in AD: sigma-1 receptor (sigma1R), beta-secretase-1 (BACE1) and acetylcholinesterase (AChE). Thioctic Acid 26-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 261-281 27402296-2 2016 RESULTS: By combining the lipoic acid structure with N-benzylpiperidine or N,N-dibenzyl(N-methyl)amine fragments, new multi-target directed ligands were obtained that act at three relevant targets in AD: sigma-1 receptor (sigma1R), beta-secretase-1 (BACE1) and acetylcholinesterase (AChE). Thioctic Acid 26-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 283-287 27402296-2 2016 RESULTS: By combining the lipoic acid structure with N-benzylpiperidine or N,N-dibenzyl(N-methyl)amine fragments, new multi-target directed ligands were obtained that act at three relevant targets in AD: sigma-1 receptor (sigma1R), beta-secretase-1 (BACE1) and acetylcholinesterase (AChE). 1-benzylpiperidine 53-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 261-281 27402296-2 2016 RESULTS: By combining the lipoic acid structure with N-benzylpiperidine or N,N-dibenzyl(N-methyl)amine fragments, new multi-target directed ligands were obtained that act at three relevant targets in AD: sigma-1 receptor (sigma1R), beta-secretase-1 (BACE1) and acetylcholinesterase (AChE). 1-benzylpiperidine 53-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 283-287 27492242-1 2016 The enzyme acetylcholinesterase is a key target in the treatment of Alzheimer"s disease because of its ability to hydrolyze acetylcholine via the catalytic binding site and to accelerate the aggregation of amyloid-beta peptide via the peripheral anionic site (PAS). Aminosalicylic Acid 260-263 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 27345502-1 2016 The insect repellent N,N-diethyl-m-toluamide (DEET) has been reported to inhibit AChE (acetylcholinesterase) and to possess potential carcinogenic properties with excessive vascularization. DEET 21-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 27345502-1 2016 The insect repellent N,N-diethyl-m-toluamide (DEET) has been reported to inhibit AChE (acetylcholinesterase) and to possess potential carcinogenic properties with excessive vascularization. DEET 21-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 27345502-1 2016 The insect repellent N,N-diethyl-m-toluamide (DEET) has been reported to inhibit AChE (acetylcholinesterase) and to possess potential carcinogenic properties with excessive vascularization. DEET 46-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 27345502-1 2016 The insect repellent N,N-diethyl-m-toluamide (DEET) has been reported to inhibit AChE (acetylcholinesterase) and to possess potential carcinogenic properties with excessive vascularization. DEET 46-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 27345502-7 2016 In addition, DEET inhibited AChE which increased acetylcholine bioavailability and binding to M3 receptors and also strengthened proangiogenic effects by an allosteric modulation. Acetylcholine 49-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 27249533-6 2016 We show proof-of-concept where acetylcholinesterase was immobilized on an organosiloxane polymer through electrostatic interactions. organosiloxane polymer 74-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 27249533-7 2016 The hydrolysis of acetylcholine by acetylcholinesterase into choline was monitored in real-time for a range of acetylcholine concentrations, fused-silica capillary geometries, and operating flow rates. Acetylcholine 18-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 27249533-7 2016 The hydrolysis of acetylcholine by acetylcholinesterase into choline was monitored in real-time for a range of acetylcholine concentrations, fused-silica capillary geometries, and operating flow rates. Choline 24-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 26548365-2 2016 The design, synthesis, and pharmacological evaluation of various derivatives led to the identification of aminobenzimidazoles as second-generation leads with micro- or sub-micromolar activities at both targets and excellent selectivity over hCB1 and AChE, respectively. aminobenzimidazoles 106-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 250-254 27169678-6 2016 Time-resolved luminescence and pH measurements under conditions of AChE-catalyzed hydrolysis of ACh show a good correlation between the cluster-centered luminescence and pH-induced inhibition of AChE. Acetylcholine 67-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 27169678-9 2016 The usability of cluster-centered luminescence for monitoring the concentration-dependent inhibition of AChE with irreversible inhibitors is demonstrated, using a carbamylating agent, pyridostigmine bromide, as a model. Pyridostigmine Bromide 184-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 27179675-7 2016 Based on the full information provided by this method, the efficacy of reactivators, such as HI-6, obidoxime and pralidoxime, in the typical treatment of NAs poisoned AChE in in vitro was further evaluated. asoxime chloride 93-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 27179675-7 2016 Based on the full information provided by this method, the efficacy of reactivators, such as HI-6, obidoxime and pralidoxime, in the typical treatment of NAs poisoned AChE in in vitro was further evaluated. pralidoxime 113-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 27283196-1 2016 BACKGROUND: Acetylcholinesterase (AChE) is an important metabolic enzyme of schistosomes present in the musculature and on the surface of the blood stage where it has been implicated in the modulation of glucose scavenging from mammalian host blood. Glucose 204-211 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 27283196-1 2016 BACKGROUND: Acetylcholinesterase (AChE) is an important metabolic enzyme of schistosomes present in the musculature and on the surface of the blood stage where it has been implicated in the modulation of glucose scavenging from mammalian host blood. Glucose 204-211 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 27283196-3 2016 Recently, using a schistosome protein microarray, a predicted S. japonicum acetylcholinesterase precursor was significantly targeted by protective IgG1 immune responses in S. haematobium-exposed individuals that had acquired drug-induced resistance to schistosomiasis after praziquantel treatment. Praziquantel 274-286 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 27106028-1 2016 We evaluated the major active components isolated from Corni Fructus: loganin, morroniside, and 7-O-galloyl-D-sedoheptulose as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) for use in Alzheimer"s disease treatment. loganin 70-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 27135466-0 2016 Exploration of a Library of 3,4-(Methylenedioxy)aniline-Derived Semicarbazones as Dual Inhibitors of Monoamine Oxidase and Acetylcholinesterase: Design, Synthesis, and Evaluation. 3,4-(methylenedioxy)aniline-derived semicarbazones 28-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-143 27135466-1 2016 A library of 3,4-(methylenedioxy)aniline-derived semicarbazones was designed, synthesized, and evaluated as monoamine oxidase (MAO) and acetylcholinesterase (AChE) inhibitors for the treatment of neurodegenerative diseases. 3,4-(methylenedioxy)aniline-derived semicarbazones 13-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 27135466-3 2016 Compound 16, 1-(2,6-dichlorobenzylidene)-4-(benzo[1,3]dioxol-5-yl)semicarbazide presented a balanced multifunctional profile of MAO-A (IC50 =4.52+-0.032 mum), MAO-B (IC50 =0.059+-0.002 mum), and AChE (IC50 =0.0087+-0.0002 mum) inhibition without neurotoxicity. 16, 1-(2,6-dichlorobenzylidene)-4-(benzo[1,3]dioxol-5-yl)semicarbazide 9-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 27327269-1 2016 Aging is a dealkylation reaction of organophosphorus (OP)-inhibited acetylcholinesterase (AChE). organophosphorus 36-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 27327269-2 2016 Despite many studies to date, aged AChE cannot be reactivated directly by traditional pyridinium oximes. pyridinium oximes 86-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 27327269-6 2016 For postaging treatment, realkylation of aged AChE by appropriate alkylators may pave the way for oxime treatment by neutralizing the oxyanion at the active site of aged AChE. Oximes 98-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 27327269-6 2016 For postaging treatment, realkylation of aged AChE by appropriate alkylators may pave the way for oxime treatment by neutralizing the oxyanion at the active site of aged AChE. Oximes 98-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 27106028-1 2016 We evaluated the major active components isolated from Corni Fructus: loganin, morroniside, and 7-O-galloyl-D-sedoheptulose as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) for use in Alzheimer"s disease treatment. loganin 70-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 27106028-1 2016 We evaluated the major active components isolated from Corni Fructus: loganin, morroniside, and 7-O-galloyl-D-sedoheptulose as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) for use in Alzheimer"s disease treatment. morroniside 79-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 27106028-1 2016 We evaluated the major active components isolated from Corni Fructus: loganin, morroniside, and 7-O-galloyl-D-sedoheptulose as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) for use in Alzheimer"s disease treatment. morroniside 79-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 27106028-1 2016 We evaluated the major active components isolated from Corni Fructus: loganin, morroniside, and 7-O-galloyl-D-sedoheptulose as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) for use in Alzheimer"s disease treatment. 7-O-galloyl-D-sedoheptulose 96-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 27106028-1 2016 We evaluated the major active components isolated from Corni Fructus: loganin, morroniside, and 7-O-galloyl-D-sedoheptulose as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) for use in Alzheimer"s disease treatment. 7-O-galloyl-D-sedoheptulose 96-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 26979315-0 2016 Electrochemical detection of malathion pesticide using acetylcholinesterase biosensor based on glassy carbon electrode modified with conducting polymer film. Malathion 29-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 26979315-0 2016 Electrochemical detection of malathion pesticide using acetylcholinesterase biosensor based on glassy carbon electrode modified with conducting polymer film. Carbon 102-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 26979315-0 2016 Electrochemical detection of malathion pesticide using acetylcholinesterase biosensor based on glassy carbon electrode modified with conducting polymer film. Polymers 144-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 26979315-2 2016 AChE was immobilized on PTT film surface through the covalent bond between aldehyde and amino groups. Bialaphos 24-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 26979315-2 2016 AChE was immobilized on PTT film surface through the covalent bond between aldehyde and amino groups. Aldehydes 75-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 26979315-4 2016 The biosensor showed an oxidation peak at +0.83 V related to the oxidation of thiocholine, hydrolysis product of acetylthiocholine iodide (ATCI), catalyzed by AChE. Thiocholine 78-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 26979315-4 2016 The biosensor showed an oxidation peak at +0.83 V related to the oxidation of thiocholine, hydrolysis product of acetylthiocholine iodide (ATCI), catalyzed by AChE. acetylthiocholine iodide 113-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 26979315-4 2016 The biosensor showed an oxidation peak at +0.83 V related to the oxidation of thiocholine, hydrolysis product of acetylthiocholine iodide (ATCI), catalyzed by AChE. acetylthiocholine iodide 139-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 27101948-0 2016 Oxime-mediated in vitro reactivation kinetic analysis of organophosphates-inhibited human and electric eel acetylcholinesterase. Oximes 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 26219766-0 2016 Computational studies of acetylcholinesterase complexed with fullerene derivatives: a new insight for Alzheimer disease treatment. Fullerenes 61-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 27101948-0 2016 Oxime-mediated in vitro reactivation kinetic analysis of organophosphates-inhibited human and electric eel acetylcholinesterase. Organophosphates 57-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-127 27101948-1 2016 Organophosphate (OP)-based pesticides and nerve agents are highly toxic compounds which interrupt the catalytic mechanism of acetylcholinesterase (AChE) by phosphorylating the hydroxyl moiety of serine residue. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 27101948-1 2016 Organophosphate (OP)-based pesticides and nerve agents are highly toxic compounds which interrupt the catalytic mechanism of acetylcholinesterase (AChE) by phosphorylating the hydroxyl moiety of serine residue. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 27101948-1 2016 Organophosphate (OP)-based pesticides and nerve agents are highly toxic compounds which interrupt the catalytic mechanism of acetylcholinesterase (AChE) by phosphorylating the hydroxyl moiety of serine residue. Serine 195-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 27101948-1 2016 Organophosphate (OP)-based pesticides and nerve agents are highly toxic compounds which interrupt the catalytic mechanism of acetylcholinesterase (AChE) by phosphorylating the hydroxyl moiety of serine residue. Serine 195-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 27101948-6 2016 A series of butene-linked bis-pyridinium mono oximes which vary in functional groups present at the second pyridinium ring have been examined against sarin, VX, tabun and ethyl-paraoxon-poisoned AChE. ethylparaoxon 171-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 27101948-9 2016 Studies stipulated that butene-linked oximes consisting of different functional moieties are good reactivators and found to have better efficacy to reactivate nerve agent-inhibited human AChE in comparison to eel AChE. butylene 24-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 27101948-9 2016 Studies stipulated that butene-linked oximes consisting of different functional moieties are good reactivators and found to have better efficacy to reactivate nerve agent-inhibited human AChE in comparison to eel AChE. Oximes 38-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 27101948-9 2016 Studies stipulated that butene-linked oximes consisting of different functional moieties are good reactivators and found to have better efficacy to reactivate nerve agent-inhibited human AChE in comparison to eel AChE. Oximes 38-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-217 27258420-2 2016 AChE is expressed as multiple splice variants, which may serve both cholinergic degradative functions and non-cholinergic functions unrelated with their capacity to hydrolyze acetylcholine. Acetylcholine 175-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 27252617-3 2016 MTDL-2 showed more high affinity toward the four enzymes than MTDL-1.MTDL-3 and MTDL-4, were designed containing the N-benzylpiperidinium moiety from Donepezil, a metal- chelating 8-hydroxyquinoline group and linked to a N-propargyl core and they were pharmacologically evaluated.The presence of the cyano group in MTDL-3, enhanced binding to AChE, BuChE and MAO A. Nitrogen 117-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 343-347 27252617-3 2016 MTDL-2 showed more high affinity toward the four enzymes than MTDL-1.MTDL-3 and MTDL-4, were designed containing the N-benzylpiperidinium moiety from Donepezil, a metal- chelating 8-hydroxyquinoline group and linked to a N-propargyl core and they were pharmacologically evaluated.The presence of the cyano group in MTDL-3, enhanced binding to AChE, BuChE and MAO A. mtdl-3 69-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 343-347 27252617-4 2016 It showed antioxidant behavior and it was able to strongly complex Cu(II), Zn(II) and Fe(III).MTDL-4 showed higher affinity toward AChE, BuChE.MTDL-3 exhibited good brain penetration capacity (ADMET) and less toxicity than Donepezil. mtdl-4 94-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 27252617-4 2016 It showed antioxidant behavior and it was able to strongly complex Cu(II), Zn(II) and Fe(III).MTDL-4 showed higher affinity toward AChE, BuChE.MTDL-3 exhibited good brain penetration capacity (ADMET) and less toxicity than Donepezil. mtdl-3 143-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 27136042-2 2016 Herein, we report the development of graphene oxide (GO) fluorescence-based biosensors for the detection of AChE activity and AChE inhibitors. graphene oxide 37-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 27136042-2 2016 Herein, we report the development of graphene oxide (GO) fluorescence-based biosensors for the detection of AChE activity and AChE inhibitors. graphene oxide 37-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 27136042-2 2016 Herein, we report the development of graphene oxide (GO) fluorescence-based biosensors for the detection of AChE activity and AChE inhibitors. graphene oxide 53-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 27136042-2 2016 Herein, we report the development of graphene oxide (GO) fluorescence-based biosensors for the detection of AChE activity and AChE inhibitors. graphene oxide 53-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 30090408-3 2016 Herein, we present a novel hybrid compound which is able not only to keep acetylcholinesterase resistant to organophosphate (OP) inhibitors, but also to serve as an enzyme reactivator in the case of OP intoxication. Organophosphates 108-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 27136042-4 2016 The fluorescence of PhO-dex-GO remarkably increased as AChE catalyzed the hydrolysis of acetylthiocholine (ATCh) to give thiocholine and acetic acid. phosphorylethanolamine 20-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 27136042-4 2016 The fluorescence of PhO-dex-GO remarkably increased as AChE catalyzed the hydrolysis of acetylthiocholine (ATCh) to give thiocholine and acetic acid. dex-go 24-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 27136042-4 2016 The fluorescence of PhO-dex-GO remarkably increased as AChE catalyzed the hydrolysis of acetylthiocholine (ATCh) to give thiocholine and acetic acid. Acetylthiocholine 88-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 27136042-4 2016 The fluorescence of PhO-dex-GO remarkably increased as AChE catalyzed the hydrolysis of acetylthiocholine (ATCh) to give thiocholine and acetic acid. Acetylthiocholine 107-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 27136042-4 2016 The fluorescence of PhO-dex-GO remarkably increased as AChE catalyzed the hydrolysis of acetylthiocholine (ATCh) to give thiocholine and acetic acid. Thiocholine 94-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 27136042-4 2016 The fluorescence of PhO-dex-GO remarkably increased as AChE catalyzed the hydrolysis of acetylthiocholine (ATCh) to give thiocholine and acetic acid. Acetic Acid 137-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 27136042-5 2016 It was found that the turn-on fluorescence response of PhO-dex-GO to AChE activity was induced by protonation of carboxyl groups on it from the product of the enzymatic hydrolysis reaction, acetic acid. pho-dex-go 55-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 27136042-5 2016 It was found that the turn-on fluorescence response of PhO-dex-GO to AChE activity was induced by protonation of carboxyl groups on it from the product of the enzymatic hydrolysis reaction, acetic acid. Acetic Acid 190-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 27136042-6 2016 On the basis of its turn-on fluorescence response, PhO-dex-GO was able to report kinetic and thermodynamic parameters involving a maximum velocity, a Michaelis constant, and an inhibition dissociation constant for AChE activity and inhibition. Dextromethorphan 55-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-218 27083471-0 2016 Biological evaluation of synthetic alpha,beta-unsaturated carbonyl based cyclohexanone derivatives as neuroprotective novel inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-beta aggregation. alpha,beta-unsaturated carbonyl based cyclohexanone 35-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 27068142-0 2016 Acetylcholinesterase and carbonic anhydrase inhibitory properties of novel urea and sulfamide derivatives incorporating dopaminergic 2-aminotetralin scaffolds. Urea 75-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 27083471-8 2016 Compounds containing N-methyl-4-piperidone linker, showed high acetylcholinesterase and self-induced Abeta aggregation inhibitory activities as compared to reference drug donepezil. 1-Methyl-4-piperidone 21-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 27068142-0 2016 Acetylcholinesterase and carbonic anhydrase inhibitory properties of novel urea and sulfamide derivatives incorporating dopaminergic 2-aminotetralin scaffolds. fusarubin 84-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 27068142-0 2016 Acetylcholinesterase and carbonic anhydrase inhibitory properties of novel urea and sulfamide derivatives incorporating dopaminergic 2-aminotetralin scaffolds. 2-aminotetralin 133-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 27083471-8 2016 Compounds containing N-methyl-4-piperidone linker, showed high acetylcholinesterase and self-induced Abeta aggregation inhibitory activities as compared to reference drug donepezil. Donepezil 171-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 27068142-3 2016 The novel urea and sulfamide derivatives were tested for inhibition of hCA I, II and AChE enzymes. Urea 10-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 27083471-10 2016 Collectively, these findings suggest that some compounds from this series have potential to be promising multifunctional agents for AD treatment and our study suggest the cyclohexanone derivatives as promising new inhibitors for AChE and BuChE, potentially useful to treat neurodegenerative diseases. cyclohexanone 171-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 229-233 27068142-3 2016 The novel urea and sulfamide derivatives were tested for inhibition of hCA I, II and AChE enzymes. fusarubin 19-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 26686921-0 2016 Highly sensitive electrochemiluminescenc assay of acetylcholinesterase activity based on dual biomarkers using Pd-Au nanowires as immobilization platform. pd-au 111-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 26686921-1 2016 One-dimensional Pd-Au nanowires (Pd-Au NWs) were prepared and applied to fabricate an electrochemiluminescence (ECL) biosensor for the detection of acetylcholinesterase (AChE) activity. pd-au 16-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-168 26686921-1 2016 One-dimensional Pd-Au nanowires (Pd-Au NWs) were prepared and applied to fabricate an electrochemiluminescence (ECL) biosensor for the detection of acetylcholinesterase (AChE) activity. pd-au 16-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 26686921-1 2016 One-dimensional Pd-Au nanowires (Pd-Au NWs) were prepared and applied to fabricate an electrochemiluminescence (ECL) biosensor for the detection of acetylcholinesterase (AChE) activity. pd-au 33-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-168 26686921-1 2016 One-dimensional Pd-Au nanowires (Pd-Au NWs) were prepared and applied to fabricate an electrochemiluminescence (ECL) biosensor for the detection of acetylcholinesterase (AChE) activity. pd-au 33-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 26686921-3 2016 In the presence of AChE and choline oxidase (ChOx), acetylcholine (ATCl) is hydrolyzed by AChE to generate thiocholine, then thiocholine is catalyzed by ChOx to produce H2O2 in situ, which serves as the coreactant to effectively enhance the ECL intensity in luminol-ECL system. Acetylcholine 52-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 26686921-3 2016 In the presence of AChE and choline oxidase (ChOx), acetylcholine (ATCl) is hydrolyzed by AChE to generate thiocholine, then thiocholine is catalyzed by ChOx to produce H2O2 in situ, which serves as the coreactant to effectively enhance the ECL intensity in luminol-ECL system. Acetylcholine 52-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 26686921-3 2016 In the presence of AChE and choline oxidase (ChOx), acetylcholine (ATCl) is hydrolyzed by AChE to generate thiocholine, then thiocholine is catalyzed by ChOx to produce H2O2 in situ, which serves as the coreactant to effectively enhance the ECL intensity in luminol-ECL system. Acetylcholine 67-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 26686921-3 2016 In the presence of AChE and choline oxidase (ChOx), acetylcholine (ATCl) is hydrolyzed by AChE to generate thiocholine, then thiocholine is catalyzed by ChOx to produce H2O2 in situ, which serves as the coreactant to effectively enhance the ECL intensity in luminol-ECL system. Acetylcholine 67-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 26686921-3 2016 In the presence of AChE and choline oxidase (ChOx), acetylcholine (ATCl) is hydrolyzed by AChE to generate thiocholine, then thiocholine is catalyzed by ChOx to produce H2O2 in situ, which serves as the coreactant to effectively enhance the ECL intensity in luminol-ECL system. Thiocholine 107-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 26686921-3 2016 In the presence of AChE and choline oxidase (ChOx), acetylcholine (ATCl) is hydrolyzed by AChE to generate thiocholine, then thiocholine is catalyzed by ChOx to produce H2O2 in situ, which serves as the coreactant to effectively enhance the ECL intensity in luminol-ECL system. Thiocholine 107-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 26686921-3 2016 In the presence of AChE and choline oxidase (ChOx), acetylcholine (ATCl) is hydrolyzed by AChE to generate thiocholine, then thiocholine is catalyzed by ChOx to produce H2O2 in situ, which serves as the coreactant to effectively enhance the ECL intensity in luminol-ECL system. Thiocholine 125-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 26686921-3 2016 In the presence of AChE and choline oxidase (ChOx), acetylcholine (ATCl) is hydrolyzed by AChE to generate thiocholine, then thiocholine is catalyzed by ChOx to produce H2O2 in situ, which serves as the coreactant to effectively enhance the ECL intensity in luminol-ECL system. Thiocholine 125-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 26686921-3 2016 In the presence of AChE and choline oxidase (ChOx), acetylcholine (ATCl) is hydrolyzed by AChE to generate thiocholine, then thiocholine is catalyzed by ChOx to produce H2O2 in situ, which serves as the coreactant to effectively enhance the ECL intensity in luminol-ECL system. Hydrogen Peroxide 169-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 26686921-3 2016 In the presence of AChE and choline oxidase (ChOx), acetylcholine (ATCl) is hydrolyzed by AChE to generate thiocholine, then thiocholine is catalyzed by ChOx to produce H2O2 in situ, which serves as the coreactant to effectively enhance the ECL intensity in luminol-ECL system. Hydrogen Peroxide 169-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 26686921-3 2016 In the presence of AChE and choline oxidase (ChOx), acetylcholine (ATCl) is hydrolyzed by AChE to generate thiocholine, then thiocholine is catalyzed by ChOx to produce H2O2 in situ, which serves as the coreactant to effectively enhance the ECL intensity in luminol-ECL system. Luminol 258-265 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 27069875-2 2016 Galantamine is an acetylcholinesterase inhibitor and a positive allosteric modulator of the alpha7 nicotinic receptors. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 26686921-3 2016 In the presence of AChE and choline oxidase (ChOx), acetylcholine (ATCl) is hydrolyzed by AChE to generate thiocholine, then thiocholine is catalyzed by ChOx to produce H2O2 in situ, which serves as the coreactant to effectively enhance the ECL intensity in luminol-ECL system. Luminol 258-265 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 26686921-4 2016 The detection principle is based on the inhibited AChE and reactivated AChE as dual biomarkers, in which AChE was inhibited by organophosphorus (OP) agents, and then reactivated by obidoxime. organophosphorus 127-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 26686921-4 2016 The detection principle is based on the inhibited AChE and reactivated AChE as dual biomarkers, in which AChE was inhibited by organophosphorus (OP) agents, and then reactivated by obidoxime. organophosphorus 127-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 26686921-4 2016 The detection principle is based on the inhibited AChE and reactivated AChE as dual biomarkers, in which AChE was inhibited by organophosphorus (OP) agents, and then reactivated by obidoxime. Obidoxime Chloride 181-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 26686921-4 2016 The detection principle is based on the inhibited AChE and reactivated AChE as dual biomarkers, in which AChE was inhibited by organophosphorus (OP) agents, and then reactivated by obidoxime. Obidoxime Chloride 181-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 26832327-0 2016 Design and prediction of new acetylcholinesterase inhibitor via quantitative structure activity relationship of huprines derivatives. huprines 112-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 27109895-0 2016 Dynamics of human acetylcholinesterase bound to non-covalent and covalent inhibitors shedding light on changes to the water network structure. Water 118-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 26832327-2 2016 Comparative quantitative structure-activity relationship (QSAR) analyses on some huprines inhibitors against AChE were carried out using comparative molecular field analysis (CoMFA), comparative molecular similarity indices analysis (CoMSIA), and hologram QSAR (HQSAR) methods. huprines 81-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 26832327-6 2016 The analysis was performed by combining the CoMFA and CoMSIA field distributions with the active sites of the AChE to further understand the vital interactions between huprines and the protease. huprines 168-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 27199640-10 2016 Examples from this approach are ASS234 with properties similar to rasagiline, and donecopride, a hybrid of an acetylcholinesterase inhibitor and a 5-HT4 receptor agonist with pro-cognitive effects. donecopride 82-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 26929400-0 2016 Slow-binding inhibition of acetylcholinesterase by an alkylammonium derivative of 6-methyluracil: mechanism and possible advantages for myasthenia gravis treatment. alkylammonium 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 26929400-0 2016 Slow-binding inhibition of acetylcholinesterase by an alkylammonium derivative of 6-methyluracil: mechanism and possible advantages for myasthenia gravis treatment. 6-methyluracil 82-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 26929400-1 2016 Inhibition of human AChE (acetylcholinesterase) and BChE (butyrylcholinesterase) by an alkylammonium derivative of 6-methyluracil, C-547, a potential drug for the treatment of MG (myasthenia gravis) was studied. alkylammonium 87-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 26929400-1 2016 Inhibition of human AChE (acetylcholinesterase) and BChE (butyrylcholinesterase) by an alkylammonium derivative of 6-methyluracil, C-547, a potential drug for the treatment of MG (myasthenia gravis) was studied. alkylammonium 87-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 26929400-1 2016 Inhibition of human AChE (acetylcholinesterase) and BChE (butyrylcholinesterase) by an alkylammonium derivative of 6-methyluracil, C-547, a potential drug for the treatment of MG (myasthenia gravis) was studied. 6-methyluracil 115-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 26929400-1 2016 Inhibition of human AChE (acetylcholinesterase) and BChE (butyrylcholinesterase) by an alkylammonium derivative of 6-methyluracil, C-547, a potential drug for the treatment of MG (myasthenia gravis) was studied. 6-methyluracil 115-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 26929400-1 2016 Inhibition of human AChE (acetylcholinesterase) and BChE (butyrylcholinesterase) by an alkylammonium derivative of 6-methyluracil, C-547, a potential drug for the treatment of MG (myasthenia gravis) was studied. c-547 131-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 26929400-1 2016 Inhibition of human AChE (acetylcholinesterase) and BChE (butyrylcholinesterase) by an alkylammonium derivative of 6-methyluracil, C-547, a potential drug for the treatment of MG (myasthenia gravis) was studied. c-547 131-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 26929400-10 2016 Thus C-547 is one of the most potent and selective reversible inhibitors of AChE with a long residence time, tau=20 min, longer than for other reversible inhibitors used in the treatment of MG. c-547 5-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 27017111-0 2016 Design, synthesis and bioactivity of novel phthalimide derivatives as acetylcholinesterase inhibitors. phthalimide 43-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 27102179-3 2016 As such, it is logical to assume that the currently accepted therapies for organophosphate poisoning (muscarinic antagonist atropine and the oxime acetylcholinesterase reactivator pralidoxime chloride [2-PAM Cl]) could afford therapeutic protection. pralidoxime 180-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 26974580-0 2016 Fluorescence properties and sequestration of peripheral anionic site specific ligands in bile acid hosts: Effect on acetylcholinesterase inhibition activity. Bile Acids and Salts 89-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 27055393-0 2016 Development of a biosensing system for tacrine based on nitrogen-doped graphene quantum dots and acetylcholinesterase. Tacrine 39-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 27055393-1 2016 This work presents a novel fluorescent sensor for the determination of tacrine by combining the magnificent fluorescence properties of nitrogen-doped graphene quantum dots (N-GQDs) with the high potential of acetylcholinesterase (AChE) enzyme for screening its inhibitors. Tacrine 71-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-228 27055393-1 2016 This work presents a novel fluorescent sensor for the determination of tacrine by combining the magnificent fluorescence properties of nitrogen-doped graphene quantum dots (N-GQDs) with the high potential of acetylcholinesterase (AChE) enzyme for screening its inhibitors. Tacrine 71-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 230-234 27055393-1 2016 This work presents a novel fluorescent sensor for the determination of tacrine by combining the magnificent fluorescence properties of nitrogen-doped graphene quantum dots (N-GQDs) with the high potential of acetylcholinesterase (AChE) enzyme for screening its inhibitors. Nitrogen 135-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 230-234 27055393-2 2016 Tacrine was the first drug approved for Alzheimer"s disease and it is currently being used in several therapeutic treatments given its activity as a reversible inhibitor of AChE. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-177 27605862-2 2016 Huperzine A (HupA), a Traditional Chinese Medicine derived from a genus of clubmosses known as Huperzineserrata, is a powerful AChE inhibitor that has been used as an adjunctive treatment for MDD, but no meta-analysis on HupA augmentation for MDD has yet been reported. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 27605862-2 2016 Huperzine A (HupA), a Traditional Chinese Medicine derived from a genus of clubmosses known as Huperzineserrata, is a powerful AChE inhibitor that has been used as an adjunctive treatment for MDD, but no meta-analysis on HupA augmentation for MDD has yet been reported. huperzine A 13-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 26947607-1 2016 A series of pterostilbene-O-acetamidoalkylbenzylamines were designed, synthesized and evaluated as dual inhibitors of AChE and BuChE. pterostilbene-o-acetamidoalkylbenzylamines 12-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 26947607-5 2016 Both the inhibition kinetic analysis and molecular modeling study revealed that these compounds showed mixed-type inhibition, binding simultaneously to the CAS and PAS of AChE. Protactinium 164-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 27016441-3 2016 The presence of organophosphorous pesticides (OPs) can inhibit the AChE activity and thus changes the fluorescent intensity of QDs/AChE microscopic dot arrays. organophosphorous 16-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 27016441-3 2016 The presence of organophosphorous pesticides (OPs) can inhibit the AChE activity and thus changes the fluorescent intensity of QDs/AChE microscopic dot arrays. organophosphorous 16-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 27132127-1 2016 Organophosphorus (OP) and N-methylcarbamate pesticides inhibit acetylcholinesterase (AChE), but differences in metabolism and detoxication can influence potency of these pesticides across and within species. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 26965078-5 2016 This was followed by NIMP then paraoxon and DFP with rat and mouse brain AChE but DFP was a more potent inhibitor than NIMP and paraoxon with human AChE. nimp 119-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 26965078-5 2016 This was followed by NIMP then paraoxon and DFP with rat and mouse brain AChE but DFP was a more potent inhibitor than NIMP and paraoxon with human AChE. Paraoxon 128-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 27000635-0 2016 Is it possible to reverse aged acetylcholinesterase inhibited by organophosphorus compounds? organophosphorus 65-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 27000635-2 2016 The main treatment for organophosphorus (OP) compound poisoning in clinics is to restore the activity of acetylcholinesterase (AChE) through oxime-induced reactivation of the phosphorylated OP-AChE adduct. organophosphorus 23-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 27000635-2 2016 The main treatment for organophosphorus (OP) compound poisoning in clinics is to restore the activity of acetylcholinesterase (AChE) through oxime-induced reactivation of the phosphorylated OP-AChE adduct. organophosphorus 23-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 27000635-2 2016 The main treatment for organophosphorus (OP) compound poisoning in clinics is to restore the activity of acetylcholinesterase (AChE) through oxime-induced reactivation of the phosphorylated OP-AChE adduct. organophosphorus 23-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-197 27000635-2 2016 The main treatment for organophosphorus (OP) compound poisoning in clinics is to restore the activity of acetylcholinesterase (AChE) through oxime-induced reactivation of the phosphorylated OP-AChE adduct. Oximes 141-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 27000635-2 2016 The main treatment for organophosphorus (OP) compound poisoning in clinics is to restore the activity of acetylcholinesterase (AChE) through oxime-induced reactivation of the phosphorylated OP-AChE adduct. Oximes 141-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 27000635-2 2016 The main treatment for organophosphorus (OP) compound poisoning in clinics is to restore the activity of acetylcholinesterase (AChE) through oxime-induced reactivation of the phosphorylated OP-AChE adduct. Oximes 141-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-197 27000635-4 2016 However, it was recently reported that N-methyl-2-methoxypyridinium species can act as methylating agents to methylate the methyl methane-phosphonate monoanion, in which the reaction mimics the reverse of the aging reaction of the phosphorylated OP-AChE adduct. n-methyl-2-methoxypyridinium 39-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 249-253 27000635-4 2016 However, it was recently reported that N-methyl-2-methoxypyridinium species can act as methylating agents to methylate the methyl methane-phosphonate monoanion, in which the reaction mimics the reverse of the aging reaction of the phosphorylated OP-AChE adduct. methyl methane-phosphonate monoanion 123-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 249-253 27000635-8 2016 In the present study, we performed DFT calculations and quantum mechanical/molecular mechanical (QM/MM) calculations to reveal the fundamental mechanism for the methylation of both the methyl methane-phosphonate monoanion and the aged sarin-AChE adduct by N-methyl-2-methoxypyridinium species, respectively. n-methyl-2-methoxypyridinium 256-284 acetylcholinesterase (Cartwright blood group) Homo sapiens 241-245 27000635-11 2016 The methylation of the aged sarin-AChE adduct by one N-methyl-2-methoxypyridinium compound (labeled as compound 2) also employs the SN2 reaction mechanism with an extremely high free energy barrier of 30.4 +- 3.5 (or 26.6) kcal mol(-1), implying that this reaction in the enzyme hardly occurs. n-methyl-2-methoxypyridinium 53-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 26953358-0 2016 A sensitive magnetic nanoparticle-based immunoassay of phosphorylated acetylcholinesterase using protein cage templated lead phosphate for signal amplification with graphite furnace atomic absorption spectrometry detection. lead phosphate 120-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 26953358-2 2016 OP-AChE adducts were firstly captured by titanium dioxide coated magnetic nanoparticles (TiO2-MNPs) from the sample matrixes through metal chelation with phospho-moieties, and then selectively recognized by anti-AChE antibody labeled on PCN which was packed with lead phosphate in its cavity (PCN-anti-AChE). titanium dioxide 41-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 3-7 26953358-2 2016 OP-AChE adducts were firstly captured by titanium dioxide coated magnetic nanoparticles (TiO2-MNPs) from the sample matrixes through metal chelation with phospho-moieties, and then selectively recognized by anti-AChE antibody labeled on PCN which was packed with lead phosphate in its cavity (PCN-anti-AChE). titanium dioxide 41-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 212-216 26953358-2 2016 OP-AChE adducts were firstly captured by titanium dioxide coated magnetic nanoparticles (TiO2-MNPs) from the sample matrixes through metal chelation with phospho-moieties, and then selectively recognized by anti-AChE antibody labeled on PCN which was packed with lead phosphate in its cavity (PCN-anti-AChE). titanium dioxide 41-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 212-216 26953358-2 2016 OP-AChE adducts were firstly captured by titanium dioxide coated magnetic nanoparticles (TiO2-MNPs) from the sample matrixes through metal chelation with phospho-moieties, and then selectively recognized by anti-AChE antibody labeled on PCN which was packed with lead phosphate in its cavity (PCN-anti-AChE). lead phosphate 263-277 acetylcholinesterase (Cartwright blood group) Homo sapiens 3-7 26902639-1 2016 Human serum albumin (HSA) induced modulation of acetylcholinesterase (AChE) inhibition activity of four well-known cholinergic inhibitors like tacrine hydrochloride (TAC), donepezil hydrochloride monohydrate (DON), (-) Huperzine A (HuPA), eserine (ESE) was monitored quantitatively by Ellman"s method. Tacrine 143-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 26902639-1 2016 Human serum albumin (HSA) induced modulation of acetylcholinesterase (AChE) inhibition activity of four well-known cholinergic inhibitors like tacrine hydrochloride (TAC), donepezil hydrochloride monohydrate (DON), (-) Huperzine A (HuPA), eserine (ESE) was monitored quantitatively by Ellman"s method. Tacrine 143-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 26902639-1 2016 Human serum albumin (HSA) induced modulation of acetylcholinesterase (AChE) inhibition activity of four well-known cholinergic inhibitors like tacrine hydrochloride (TAC), donepezil hydrochloride monohydrate (DON), (-) Huperzine A (HuPA), eserine (ESE) was monitored quantitatively by Ellman"s method. Tacrine 166-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 26902639-1 2016 Human serum albumin (HSA) induced modulation of acetylcholinesterase (AChE) inhibition activity of four well-known cholinergic inhibitors like tacrine hydrochloride (TAC), donepezil hydrochloride monohydrate (DON), (-) Huperzine A (HuPA), eserine (ESE) was monitored quantitatively by Ellman"s method. Tacrine 166-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 26902639-1 2016 Human serum albumin (HSA) induced modulation of acetylcholinesterase (AChE) inhibition activity of four well-known cholinergic inhibitors like tacrine hydrochloride (TAC), donepezil hydrochloride monohydrate (DON), (-) Huperzine A (HuPA), eserine (ESE) was monitored quantitatively by Ellman"s method. Donepezil hydrochloride monohydrate 172-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 26902639-1 2016 Human serum albumin (HSA) induced modulation of acetylcholinesterase (AChE) inhibition activity of four well-known cholinergic inhibitors like tacrine hydrochloride (TAC), donepezil hydrochloride monohydrate (DON), (-) Huperzine A (HuPA), eserine (ESE) was monitored quantitatively by Ellman"s method. Donepezil hydrochloride monohydrate 172-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 26902639-1 2016 Human serum albumin (HSA) induced modulation of acetylcholinesterase (AChE) inhibition activity of four well-known cholinergic inhibitors like tacrine hydrochloride (TAC), donepezil hydrochloride monohydrate (DON), (-) Huperzine A (HuPA), eserine (ESE) was monitored quantitatively by Ellman"s method. Diazooxonorleucine 209-212 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 26902639-1 2016 Human serum albumin (HSA) induced modulation of acetylcholinesterase (AChE) inhibition activity of four well-known cholinergic inhibitors like tacrine hydrochloride (TAC), donepezil hydrochloride monohydrate (DON), (-) Huperzine A (HuPA), eserine (ESE) was monitored quantitatively by Ellman"s method. huperzine A 219-230 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 26902639-1 2016 Human serum albumin (HSA) induced modulation of acetylcholinesterase (AChE) inhibition activity of four well-known cholinergic inhibitors like tacrine hydrochloride (TAC), donepezil hydrochloride monohydrate (DON), (-) Huperzine A (HuPA), eserine (ESE) was monitored quantitatively by Ellman"s method. huperzine A 232-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 26902639-1 2016 Human serum albumin (HSA) induced modulation of acetylcholinesterase (AChE) inhibition activity of four well-known cholinergic inhibitors like tacrine hydrochloride (TAC), donepezil hydrochloride monohydrate (DON), (-) Huperzine A (HuPA), eserine (ESE) was monitored quantitatively by Ellman"s method. Physostigmine 239-246 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 26902639-1 2016 Human serum albumin (HSA) induced modulation of acetylcholinesterase (AChE) inhibition activity of four well-known cholinergic inhibitors like tacrine hydrochloride (TAC), donepezil hydrochloride monohydrate (DON), (-) Huperzine A (HuPA), eserine (ESE) was monitored quantitatively by Ellman"s method. Physostigmine 248-251 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 26898241-1 2016 In order to develop potent dual-binding cholinesterase inhibitors as potential drugs for the treatment of Alzheimer"s disease, we designed and synthesized phthalimide-based acetylcholinesterase (AChE) inhibitors (7) containing a substituted N-benzylpyridinium residue. phthalimide 155-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-54 26898241-1 2016 In order to develop potent dual-binding cholinesterase inhibitors as potential drugs for the treatment of Alzheimer"s disease, we designed and synthesized phthalimide-based acetylcholinesterase (AChE) inhibitors (7) containing a substituted N-benzylpyridinium residue. phthalimide 155-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-193 26898241-1 2016 In order to develop potent dual-binding cholinesterase inhibitors as potential drugs for the treatment of Alzheimer"s disease, we designed and synthesized phthalimide-based acetylcholinesterase (AChE) inhibitors (7) containing a substituted N-benzylpyridinium residue. phthalimide 155-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 26898241-1 2016 In order to develop potent dual-binding cholinesterase inhibitors as potential drugs for the treatment of Alzheimer"s disease, we designed and synthesized phthalimide-based acetylcholinesterase (AChE) inhibitors (7) containing a substituted N-benzylpyridinium residue. n-benzylpyridinium 241-259 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-193 26898241-1 2016 In order to develop potent dual-binding cholinesterase inhibitors as potential drugs for the treatment of Alzheimer"s disease, we designed and synthesized phthalimide-based acetylcholinesterase (AChE) inhibitors (7) containing a substituted N-benzylpyridinium residue. n-benzylpyridinium 241-259 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 26898241-2 2016 The in vitro anti-cholinesterase assay employing the target compounds against AChE and butyrylcholinesterase (BChE) revealed the 2-fluorobenzylpyridinium derivative 7d as the most potent compound against both enzymes, with IC50 values of 0.77 and 8.71 muM. 2-fluorobenzylpyridinium 129-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-32 26898241-2 2016 The in vitro anti-cholinesterase assay employing the target compounds against AChE and butyrylcholinesterase (BChE) revealed the 2-fluorobenzylpyridinium derivative 7d as the most potent compound against both enzymes, with IC50 values of 0.77 and 8.71 muM. 2-fluorobenzylpyridinium 129-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 26943478-0 2016 Synthesis and anti-acetylcholinesterase activity of scopoletin derivatives. Scopoletin 52-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 26943478-1 2016 A series of scopoletin derivatives incorporated with the pyridinium moiety was synthesized and evaluated for their acetylcholinesterase (AChE) inhibitory activity by the colorimetric Ellman"s method. Scopoletin 12-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 26943478-1 2016 A series of scopoletin derivatives incorporated with the pyridinium moiety was synthesized and evaluated for their acetylcholinesterase (AChE) inhibitory activity by the colorimetric Ellman"s method. Scopoletin 12-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 26943478-3 2016 Docking studies revealed that the scopoletin portion of the mentioned compound was bound to the peripheral anionic site of the AChE, whereas the N-benzylpyridinium residue to the catalytic anionic site. Scopoletin 34-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 26947959-1 2016 In the current study, sixteen novel derivatives of (R)-1-(6-fluorobenzo[d]thiazol-2-yl)ethanamine were synthesized as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. (R)-1-(6-FLUOROBENZO[D]THIAZOL-2-YL)ETHANAMINE 51-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 26947959-1 2016 In the current study, sixteen novel derivatives of (R)-1-(6-fluorobenzo[d]thiazol-2-yl)ethanamine were synthesized as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. (R)-1-(6-FLUOROBENZO[D]THIAZOL-2-YL)ETHANAMINE 51-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 26947959-7 2016 Compounds indicated as 3b, 3d, 3l and 3n showed the best AChE inhibitory activity of all the evaluated compounds and were up to tenfold more potent than standard drug rivastigmine. Rivastigmine 167-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 26947959-9 2016 The obtained data clearly demonstrated that 3b, 3d, 3l and 3n benzothiazole carbamates possess high inhibitory activity against AChE and BChE and concurrently negligible cytotoxicity. benzothiazole carbamates 62-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 27054123-7 2016 There was significantly less AChE activity in farmers exposed to organophosphorus pesticides. organophosphorus 65-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 27054123-9 2016 CONCLUSION: The outcomes show that exposure to organophosphorus pesticides may cause DNA oxidative damage, inhibit AChE activity and increase the serum levels of inflammatory markers. organophosphorus 47-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 27132127-1 2016 Organophosphorus (OP) and N-methylcarbamate pesticides inhibit acetylcholinesterase (AChE), but differences in metabolism and detoxication can influence potency of these pesticides across and within species. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 27132127-1 2016 Organophosphorus (OP) and N-methylcarbamate pesticides inhibit acetylcholinesterase (AChE), but differences in metabolism and detoxication can influence potency of these pesticides across and within species. N-methylcarbamate 26-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 27132127-1 2016 Organophosphorus (OP) and N-methylcarbamate pesticides inhibit acetylcholinesterase (AChE), but differences in metabolism and detoxication can influence potency of these pesticides across and within species. N-methylcarbamate 26-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 27055524-0 2016 A mechanism-based 3D-QSAR approach for classification and prediction of acetylcholinesterase inhibitory potency of organophosphate and carbamate analogs. Organophosphates 115-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 27055524-0 2016 A mechanism-based 3D-QSAR approach for classification and prediction of acetylcholinesterase inhibitory potency of organophosphate and carbamate analogs. Carbamates 135-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 27055524-1 2016 Organophosphate (OP) and carbamate esters can inhibit acetylcholinesterase (AChE) by binding covalently to a serine residue in the enzyme active site, and their inhibitory potency depends largely on affinity for the enzyme and the reactivity of the ester. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 27055524-1 2016 Organophosphate (OP) and carbamate esters can inhibit acetylcholinesterase (AChE) by binding covalently to a serine residue in the enzyme active site, and their inhibitory potency depends largely on affinity for the enzyme and the reactivity of the ester. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 27055524-1 2016 Organophosphate (OP) and carbamate esters can inhibit acetylcholinesterase (AChE) by binding covalently to a serine residue in the enzyme active site, and their inhibitory potency depends largely on affinity for the enzyme and the reactivity of the ester. carbamate esters 25-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 27055524-1 2016 Organophosphate (OP) and carbamate esters can inhibit acetylcholinesterase (AChE) by binding covalently to a serine residue in the enzyme active site, and their inhibitory potency depends largely on affinity for the enzyme and the reactivity of the ester. carbamate esters 25-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 27055524-1 2016 Organophosphate (OP) and carbamate esters can inhibit acetylcholinesterase (AChE) by binding covalently to a serine residue in the enzyme active site, and their inhibitory potency depends largely on affinity for the enzyme and the reactivity of the ester. Serine 109-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 27055524-1 2016 Organophosphate (OP) and carbamate esters can inhibit acetylcholinesterase (AChE) by binding covalently to a serine residue in the enzyme active site, and their inhibitory potency depends largely on affinity for the enzyme and the reactivity of the ester. Serine 109-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 27055524-1 2016 Organophosphate (OP) and carbamate esters can inhibit acetylcholinesterase (AChE) by binding covalently to a serine residue in the enzyme active site, and their inhibitory potency depends largely on affinity for the enzyme and the reactivity of the ester. Esters 35-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 27055524-1 2016 Organophosphate (OP) and carbamate esters can inhibit acetylcholinesterase (AChE) by binding covalently to a serine residue in the enzyme active site, and their inhibitory potency depends largely on affinity for the enzyme and the reactivity of the ester. Esters 35-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 26879641-2 2016 We have examined the structural features of the tabun-conjugated AChE complex with an oxime reactivator, Ortho-7, to provide a strategy for designing new and efficient reactivators. Oximes 86-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 26738844-3 2016 The goal of this pilot study was to examine the efficacy of donepezil, an acetylcholinesterase inhibitor used to treat Alzheimer"s disease, in improving cognitive functions in brain tumor patients previously treated with RT + chemotherapy or chemotherapy alone. Donepezil 60-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 26851641-1 2016 Standard therapy of poisoning by organophosphorus compounds (OP) is a combined administration of an anti-muscarinic drug (e.g. atropine) and an oxime as reactivator of inhibited acetylcholinesterase (AChE). Oximes 144-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-198 26293308-1 2016 Studies of acetylcholine degrading enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in Alzheimer"s disease (AD) have suggested their potential role in the development of fibrillar amyloid-beta (Abeta) plaques (amyloid plaques). Acetylcholine 11-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 27190595-0 2016 Design, Synthesis, and Evaluation of Donepezil-Like Compounds as AChE and BACE-1 Inhibitors. Donepezil 37-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 27153754-0 2016 Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics. Obidoxime Chloride 68-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 27153754-0 2016 Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics. asoxime chloride 79-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 27153754-0 2016 Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics. Obidoxime Chloride 88-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 27153754-0 2016 Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics. asoxime chloride 98-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 27153754-0 2016 Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics. Oximes 72-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 27153754-3 2016 To investigate the ability of obidoxime, HI-6 and the combination of both oximes to reactivate inhibited human AChE in the presence of sarin, cyclosarin or tabun we adopted a dynamic in vitro model with real-time and continuous determination of AChE activity to simulate inhalation nerve agent exposure and intramuscular oxime administration. Oximes 74-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 27153754-5 2016 The oxime-induced reactivation of inhibited human AChE in the presence of nerve agents is markedly impaired and the combination of obidoxime and HI-6 had no additive effect but could broaden the spectrum. Oximes 4-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 27153754-5 2016 The oxime-induced reactivation of inhibited human AChE in the presence of nerve agents is markedly impaired and the combination of obidoxime and HI-6 had no additive effect but could broaden the spectrum. Obidoxime Chloride 131-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 27153754-5 2016 The oxime-induced reactivation of inhibited human AChE in the presence of nerve agents is markedly impaired and the combination of obidoxime and HI-6 had no additive effect but could broaden the spectrum. asoxime chloride 145-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 26809136-4 2016 The ortho-hydroxylbenzaldoximes were chosen as reactivation ligands of AChE to prevent the secondary poisoning of AChE, and simple aromatic groups were used as peripheral site ligands of AChE, which were linked to the oximes in a similar way as that found in the reactivator HI-6. Oximes 25-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 26809136-5 2016 The in vitro experiment demonstrated that some of the resulting conjugates have robust activity against soman-inhibited AChE, and oxime 8b was highlighted as the most efficient one. oxime 8b 130-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 26851641-1 2016 Standard therapy of poisoning by organophosphorus compounds (OP) is a combined administration of an anti-muscarinic drug (e.g. atropine) and an oxime as reactivator of inhibited acetylcholinesterase (AChE). Organophosphorus Compounds 33-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-198 26851641-1 2016 Standard therapy of poisoning by organophosphorus compounds (OP) is a combined administration of an anti-muscarinic drug (e.g. atropine) and an oxime as reactivator of inhibited acetylcholinesterase (AChE). Organophosphorus Compounds 33-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-204 26851641-1 2016 Standard therapy of poisoning by organophosphorus compounds (OP) is a combined administration of an anti-muscarinic drug (e.g. atropine) and an oxime as reactivator of inhibited acetylcholinesterase (AChE). Oximes 144-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-204 26851641-3 2016 Recently, reactivation of OP-inhibited AChE by the antimalarial drug amodiaquine was reported. Amodiaquine 69-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 26851641-5 2016 Thereby, reversible inhibition of human cholinesterases by amodiaquine (AChE >> BChE) was observed. Amodiaquine 59-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 26851641-6 2016 Additionally, a mixed competitive-non-competitive inhibition type of amodiaquine with human AChE was determined. Amodiaquine 69-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 26851641-8 2016 Amodiaquine, being a potent, reversible AChE inhibitor, was tested for its potential benefit as a pretreatment to prevent complete irreversible AChE inhibition by the nerve agent soman. Amodiaquine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 26851641-8 2016 Amodiaquine, being a potent, reversible AChE inhibitor, was tested for its potential benefit as a pretreatment to prevent complete irreversible AChE inhibition by the nerve agent soman. Amodiaquine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 26851641-9 2016 Hereby, amodiaquine failed to prevent phosphonylation and resulted only in a slight increase of AChE activity after removal of amodiaquine and soman. Amodiaquine 8-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 26851641-9 2016 Hereby, amodiaquine failed to prevent phosphonylation and resulted only in a slight increase of AChE activity after removal of amodiaquine and soman. Amodiaquine 127-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 26851641-10 2016 At present the molecular mechanism of amodiaquine-induced reactivation of OP-inhibited AChE is not known, nevertheless amodiaquine could be considered as a template for the design of more potent non-oxime reactivators. Amodiaquine 38-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 26999091-0 2016 Searching for Multi-Targeting Neurotherapeutics against Alzheimer"s: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif. 2h-chromen-2- 141-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 26869193-0 2016 In silico to in vitro screening of hydroxypyridinones as acetylcholinesterase inhibitors. 1-hydroxy-2(1H)-pyridinone 35-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 26516688-7 2016 Results confirm that reliable fluorescent monitoring AChE-catalyzed hydrolysis of ACh is possible through the H-function properties of Tb(III)-doped silica nanoparticles. tb(iii) 135-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 26516688-7 2016 Results confirm that reliable fluorescent monitoring AChE-catalyzed hydrolysis of ACh is possible through the H-function properties of Tb(III)-doped silica nanoparticles. Silicon Dioxide 149-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 26492468-2 2016 A highly sensitive fluorescent biosensor for the detection of carbamate pesticide has been developed based on acetylcholinesterase (AChE)-catalyzed hydrolysis product triggered Hg(2+) release coupled with subsequent nicking enzyme-induced cleavage of a duplex DNA for cycling amplification. Carbamates 62-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 26492468-2 2016 A highly sensitive fluorescent biosensor for the detection of carbamate pesticide has been developed based on acetylcholinesterase (AChE)-catalyzed hydrolysis product triggered Hg(2+) release coupled with subsequent nicking enzyme-induced cleavage of a duplex DNA for cycling amplification. Carbamates 62-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 26492468-6 2016 In the presence of carbamate pesticide, the activity of AChE is inhibited, and the amount of the product containing the thiol group generated by the hydrolysis reaction of acetylthiocholine chloride (ACh) decreases, resulting in the release of a low concentration of Hg(2+). Carbamates 19-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 26492468-6 2016 In the presence of carbamate pesticide, the activity of AChE is inhibited, and the amount of the product containing the thiol group generated by the hydrolysis reaction of acetylthiocholine chloride (ACh) decreases, resulting in the release of a low concentration of Hg(2+). Sulfhydryl Compounds 120-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 26492468-6 2016 In the presence of carbamate pesticide, the activity of AChE is inhibited, and the amount of the product containing the thiol group generated by the hydrolysis reaction of acetylthiocholine chloride (ACh) decreases, resulting in the release of a low concentration of Hg(2+). Acetylthiocholine chloride 172-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 26869193-1 2016 We have previously shown the improved acetylcholinesterase inhibitory activity of a model hydroxypyridinone compound transforming the hydroxyl group on the main ring into an N,N-dimethylcarbamate group; in the course of that study we developed a computational model to screen compounds for enzymatic activity. 1-hydroxy-2(1H)-pyridinone 90-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 26869193-1 2016 We have previously shown the improved acetylcholinesterase inhibitory activity of a model hydroxypyridinone compound transforming the hydroxyl group on the main ring into an N,N-dimethylcarbamate group; in the course of that study we developed a computational model to screen compounds for enzymatic activity. N,N-dimethylcarbamate 174-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 25743373-1 2016 The hydroxyl oxygen of the catalytic triad serine in the active center of serine hydrolase acetylcholinesterase (AChE) attacks organophosphorus compounds (OPs) at the phosphorus atom to displace the primary leaving group and to form a covalent bond. Organophosphorus Compounds 127-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 26547618-4 2016 In the presence of acetylcholinesterase (AChE) and acetylthiocholine (ATCl), the AChE catalyzes the hydrolysis of ATCl into positively charged thiocholine which would replace the citrate on AuNPs through the strong AuS bond and convert the negative charged surface to be positively charged. Acetylthiocholine 51-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 26547618-4 2016 In the presence of acetylcholinesterase (AChE) and acetylthiocholine (ATCl), the AChE catalyzes the hydrolysis of ATCl into positively charged thiocholine which would replace the citrate on AuNPs through the strong AuS bond and convert the negative charged surface to be positively charged. Acetylthiocholine 51-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 26547618-4 2016 In the presence of acetylcholinesterase (AChE) and acetylthiocholine (ATCl), the AChE catalyzes the hydrolysis of ATCl into positively charged thiocholine which would replace the citrate on AuNPs through the strong AuS bond and convert the negative charged surface to be positively charged. Acetylthiocholine 70-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 26547618-4 2016 In the presence of acetylcholinesterase (AChE) and acetylthiocholine (ATCl), the AChE catalyzes the hydrolysis of ATCl into positively charged thiocholine which would replace the citrate on AuNPs through the strong AuS bond and convert the negative charged surface to be positively charged. Acetylthiocholine 70-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 26547618-4 2016 In the presence of acetylcholinesterase (AChE) and acetylthiocholine (ATCl), the AChE catalyzes the hydrolysis of ATCl into positively charged thiocholine which would replace the citrate on AuNPs through the strong AuS bond and convert the negative charged surface to be positively charged. Acetylthiocholine 70-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 26547618-4 2016 In the presence of acetylcholinesterase (AChE) and acetylthiocholine (ATCl), the AChE catalyzes the hydrolysis of ATCl into positively charged thiocholine which would replace the citrate on AuNPs through the strong AuS bond and convert the negative charged surface to be positively charged. Acetylthiocholine 114-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 26547618-4 2016 In the presence of acetylcholinesterase (AChE) and acetylthiocholine (ATCl), the AChE catalyzes the hydrolysis of ATCl into positively charged thiocholine which would replace the citrate on AuNPs through the strong AuS bond and convert the negative charged surface to be positively charged. Acetylthiocholine 114-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 26547618-4 2016 In the presence of acetylcholinesterase (AChE) and acetylthiocholine (ATCl), the AChE catalyzes the hydrolysis of ATCl into positively charged thiocholine which would replace the citrate on AuNPs through the strong AuS bond and convert the negative charged surface to be positively charged. Acetylthiocholine 114-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 26547618-4 2016 In the presence of acetylcholinesterase (AChE) and acetylthiocholine (ATCl), the AChE catalyzes the hydrolysis of ATCl into positively charged thiocholine which would replace the citrate on AuNPs through the strong AuS bond and convert the negative charged surface to be positively charged. Thiocholine 57-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 26547618-4 2016 In the presence of acetylcholinesterase (AChE) and acetylthiocholine (ATCl), the AChE catalyzes the hydrolysis of ATCl into positively charged thiocholine which would replace the citrate on AuNPs through the strong AuS bond and convert the negative charged surface to be positively charged. Thiocholine 57-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 26547618-4 2016 In the presence of acetylcholinesterase (AChE) and acetylthiocholine (ATCl), the AChE catalyzes the hydrolysis of ATCl into positively charged thiocholine which would replace the citrate on AuNPs through the strong AuS bond and convert the negative charged surface to be positively charged. Citric Acid 179-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 26547618-4 2016 In the presence of acetylcholinesterase (AChE) and acetylthiocholine (ATCl), the AChE catalyzes the hydrolysis of ATCl into positively charged thiocholine which would replace the citrate on AuNPs through the strong AuS bond and convert the negative charged surface to be positively charged. Citric Acid 179-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 26547618-4 2016 In the presence of acetylcholinesterase (AChE) and acetylthiocholine (ATCl), the AChE catalyzes the hydrolysis of ATCl into positively charged thiocholine which would replace the citrate on AuNPs through the strong AuS bond and convert the negative charged surface to be positively charged. Citric Acid 179-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 26547618-6 2016 Based on the inhibition of carbamate pesticides on the activity of AChE, the pesticide could be quantitatively determined at a very low potential. Carbamates 27-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 25743373-0 2016 Resolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches. mipafox 37-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 25743373-1 2016 The hydroxyl oxygen of the catalytic triad serine in the active center of serine hydrolase acetylcholinesterase (AChE) attacks organophosphorus compounds (OPs) at the phosphorus atom to displace the primary leaving group and to form a covalent bond. Oxygen 13-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 25743373-1 2016 The hydroxyl oxygen of the catalytic triad serine in the active center of serine hydrolase acetylcholinesterase (AChE) attacks organophosphorus compounds (OPs) at the phosphorus atom to displace the primary leaving group and to form a covalent bond. Oxygen 13-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 25743373-1 2016 The hydroxyl oxygen of the catalytic triad serine in the active center of serine hydrolase acetylcholinesterase (AChE) attacks organophosphorus compounds (OPs) at the phosphorus atom to displace the primary leaving group and to form a covalent bond. Serine 43-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 25743373-1 2016 The hydroxyl oxygen of the catalytic triad serine in the active center of serine hydrolase acetylcholinesterase (AChE) attacks organophosphorus compounds (OPs) at the phosphorus atom to displace the primary leaving group and to form a covalent bond. Serine 43-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 25743373-1 2016 The hydroxyl oxygen of the catalytic triad serine in the active center of serine hydrolase acetylcholinesterase (AChE) attacks organophosphorus compounds (OPs) at the phosphorus atom to displace the primary leaving group and to form a covalent bond. Organophosphorus Compounds 127-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 26886849-2 2016 A set of pseudo-irreversible BChE inhibitors with high selectivity over hAChE was synthesized based on carbamates attached to tetrahydroquinazoline scaffolds with the 2-thiophenyl compound 2p as the most potent inhibitor of eqBChE (KC = 14.3 nM) and also of hBChE (KC = 19.7 nM). Carbamates 103-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-77 26886849-2 2016 A set of pseudo-irreversible BChE inhibitors with high selectivity over hAChE was synthesized based on carbamates attached to tetrahydroquinazoline scaffolds with the 2-thiophenyl compound 2p as the most potent inhibitor of eqBChE (KC = 14.3 nM) and also of hBChE (KC = 19.7 nM). 1,2,3,4-tetrahydroquinazoline 126-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-77 26839920-3 2016 The competitive binding by a thiol group (-SH), produced in the hydrolysis reaction of acetylthiocholine (ACh) chloride with acetylcholinesterase (AChE), removes mercury ions from the base pairs, causing a nuclease-catalyzed digestion, and the subsequent electrochemical response increase due to the weak electrostatic repulsion between the product-mononucleotides and the ITO electrode. Sulfhydryl Compounds 29-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 26839920-3 2016 The competitive binding by a thiol group (-SH), produced in the hydrolysis reaction of acetylthiocholine (ACh) chloride with acetylcholinesterase (AChE), removes mercury ions from the base pairs, causing a nuclease-catalyzed digestion, and the subsequent electrochemical response increase due to the weak electrostatic repulsion between the product-mononucleotides and the ITO electrode. Sulfhydryl Compounds 29-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 26839920-3 2016 The competitive binding by a thiol group (-SH), produced in the hydrolysis reaction of acetylthiocholine (ACh) chloride with acetylcholinesterase (AChE), removes mercury ions from the base pairs, causing a nuclease-catalyzed digestion, and the subsequent electrochemical response increase due to the weak electrostatic repulsion between the product-mononucleotides and the ITO electrode. Acetylthiocholine 87-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 26839920-3 2016 The competitive binding by a thiol group (-SH), produced in the hydrolysis reaction of acetylthiocholine (ACh) chloride with acetylcholinesterase (AChE), removes mercury ions from the base pairs, causing a nuclease-catalyzed digestion, and the subsequent electrochemical response increase due to the weak electrostatic repulsion between the product-mononucleotides and the ITO electrode. Acetylthiocholine 87-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 26839920-3 2016 The competitive binding by a thiol group (-SH), produced in the hydrolysis reaction of acetylthiocholine (ACh) chloride with acetylcholinesterase (AChE), removes mercury ions from the base pairs, causing a nuclease-catalyzed digestion, and the subsequent electrochemical response increase due to the weak electrostatic repulsion between the product-mononucleotides and the ITO electrode. ach) chloride 106-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 26839920-3 2016 The competitive binding by a thiol group (-SH), produced in the hydrolysis reaction of acetylthiocholine (ACh) chloride with acetylcholinesterase (AChE), removes mercury ions from the base pairs, causing a nuclease-catalyzed digestion, and the subsequent electrochemical response increase due to the weak electrostatic repulsion between the product-mononucleotides and the ITO electrode. ach) chloride 106-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 26839920-3 2016 The competitive binding by a thiol group (-SH), produced in the hydrolysis reaction of acetylthiocholine (ACh) chloride with acetylcholinesterase (AChE), removes mercury ions from the base pairs, causing a nuclease-catalyzed digestion, and the subsequent electrochemical response increase due to the weak electrostatic repulsion between the product-mononucleotides and the ITO electrode. Mercury 162-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 26839920-3 2016 The competitive binding by a thiol group (-SH), produced in the hydrolysis reaction of acetylthiocholine (ACh) chloride with acetylcholinesterase (AChE), removes mercury ions from the base pairs, causing a nuclease-catalyzed digestion, and the subsequent electrochemical response increase due to the weak electrostatic repulsion between the product-mononucleotides and the ITO electrode. Mercury 162-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 26839920-3 2016 The competitive binding by a thiol group (-SH), produced in the hydrolysis reaction of acetylthiocholine (ACh) chloride with acetylcholinesterase (AChE), removes mercury ions from the base pairs, causing a nuclease-catalyzed digestion, and the subsequent electrochemical response increase due to the weak electrostatic repulsion between the product-mononucleotides and the ITO electrode. mononucleotides 349-364 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 26839920-3 2016 The competitive binding by a thiol group (-SH), produced in the hydrolysis reaction of acetylthiocholine (ACh) chloride with acetylcholinesterase (AChE), removes mercury ions from the base pairs, causing a nuclease-catalyzed digestion, and the subsequent electrochemical response increase due to the weak electrostatic repulsion between the product-mononucleotides and the ITO electrode. mononucleotides 349-364 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 26956086-0 2016 A Novel Acetylcholinesterase Biosensor: Core-Shell Magnetic Nanoparticles Incorporating a Conjugated Polymer for the Detection of Organophosphorus Pesticides. Polymers 101-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-28 26956086-0 2016 A Novel Acetylcholinesterase Biosensor: Core-Shell Magnetic Nanoparticles Incorporating a Conjugated Polymer for the Detection of Organophosphorus Pesticides. organophosphorus 130-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-28 26956086-6 2016 Then, carboxyl group modified magnetic nanoparticles (f-MNPs) and acetylcholinesterase (AChE), the model enzyme, were co-immobilized on the polymer-coated surface. Polymers 140-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 26956086-6 2016 Then, carboxyl group modified magnetic nanoparticles (f-MNPs) and acetylcholinesterase (AChE), the model enzyme, were co-immobilized on the polymer-coated surface. Polymers 140-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 26956086-14 2016 The KM(app) value of poly(FBThF)/f-MNPs/AChE were determined as 0.73 mM. poly(fbthf 21-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 26724817-5 2016 Oligonol also displayed potent concentration-dependent inhibitory activity against AChE and BChE with IC50 values of 4.34 microg/mL and 2.07 microg/mL, respectively. oligonol 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 26827140-1 2016 A series of 31 N,N-disubstituted 2-amino-5-halomethyl-2-thiazolines was designed, synthesized, and evaluated for inhibitory potential against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and carboxylesterase (CaE). 2-amino-5-halomethyl-2-thiazolines 33-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 26827140-1 2016 A series of 31 N,N-disubstituted 2-amino-5-halomethyl-2-thiazolines was designed, synthesized, and evaluated for inhibitory potential against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and carboxylesterase (CaE). 2-amino-5-halomethyl-2-thiazolines 33-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 25743373-1 2016 The hydroxyl oxygen of the catalytic triad serine in the active center of serine hydrolase acetylcholinesterase (AChE) attacks organophosphorus compounds (OPs) at the phosphorus atom to displace the primary leaving group and to form a covalent bond. Organophosphorus Compounds 155-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 25743373-1 2016 The hydroxyl oxygen of the catalytic triad serine in the active center of serine hydrolase acetylcholinesterase (AChE) attacks organophosphorus compounds (OPs) at the phosphorus atom to displace the primary leaving group and to form a covalent bond. Organophosphorus Compounds 155-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 25743373-1 2016 The hydroxyl oxygen of the catalytic triad serine in the active center of serine hydrolase acetylcholinesterase (AChE) attacks organophosphorus compounds (OPs) at the phosphorus atom to displace the primary leaving group and to form a covalent bond. Phosphorus 133-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 25743373-1 2016 The hydroxyl oxygen of the catalytic triad serine in the active center of serine hydrolase acetylcholinesterase (AChE) attacks organophosphorus compounds (OPs) at the phosphorus atom to displace the primary leaving group and to form a covalent bond. Phosphorus 133-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 25743373-2 2016 Inhibited AChE can be reactivated by cleavage of the Ser-phosphorus bond either spontaneously or through a reaction with nucleophilic agents, such as oximes. Serine 53-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-14 25743373-2 2016 Inhibited AChE can be reactivated by cleavage of the Ser-phosphorus bond either spontaneously or through a reaction with nucleophilic agents, such as oximes. Phosphorus 57-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-14 25743373-2 2016 Inhibited AChE can be reactivated by cleavage of the Ser-phosphorus bond either spontaneously or through a reaction with nucleophilic agents, such as oximes. Oximes 150-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-14 25743373-5 2016 Here, our goal was to study oxime reactivation and aging reactions of human AChE inhibited by mipafox or a sarin analog (Flu-MPs, fluorescent methylphosphonate). Oximes 28-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 25743373-5 2016 Here, our goal was to study oxime reactivation and aging reactions of human AChE inhibited by mipafox or a sarin analog (Flu-MPs, fluorescent methylphosphonate). mipafox 94-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 25743373-5 2016 Here, our goal was to study oxime reactivation and aging reactions of human AChE inhibited by mipafox or a sarin analog (Flu-MPs, fluorescent methylphosphonate). flu-mps 121-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 25743373-5 2016 Here, our goal was to study oxime reactivation and aging reactions of human AChE inhibited by mipafox or a sarin analog (Flu-MPs, fluorescent methylphosphonate). methylphosphonic acid 142-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 25743373-8 2016 A peptide fingerprinted mass spectrometry (MS) method, which clearly distinguished the peptide with the active serine (active center peptide, ACP) of the human AChE adducted with OPs, was developed by MALDI-TOF and MALDI-TOF/TOF. Serine 111-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 27348899-1 2016 Organophosphorus compounds, such as sarin, are highly toxic nerve agents that inhibit acetylcholinesterase (AChE), but not cholinesterase, via multiple mechanisms. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 27348899-1 2016 Organophosphorus compounds, such as sarin, are highly toxic nerve agents that inhibit acetylcholinesterase (AChE), but not cholinesterase, via multiple mechanisms. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 26200596-5 2016 Butyryl (plasma) cholinesterase (BChE) and red blood cell acetylcholinesterase (RBC-AChE) revealed decreased activities, thus specific treatment with the enzyme reactivator obidoxime was started. Obidoxime Chloride 173-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 26751814-6 2016 Intranasally administered OBD was effective in partially reducing paraoxon-induced acetylcholinesterase inhibition in the brain and substantially reduced seizure severity and duration. Paraoxon 66-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 26494253-0 2016 A novel fluorogenic probe for the investigation of free thiols: Application to kinetic measurements of acetylcholinesterase activity. Sulfhydryl Compounds 56-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 26795874-3 2016 In the ReSPonD trial we aimed to assess whether ameliorating this cholinergic deficit with the acetylcholinesterase inhibitor rivastigmine would reduce gait variability. Rivastigmine 126-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 26200596-10 2016 In conclusion, obidoxime is a potent reactivator of OPP-inhibited AChE. Obidoxime Chloride 15-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 26210933-0 2016 Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase. bispyridinium oximes 64-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 26210933-0 2016 Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase. Organophosphates 90-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 26210933-1 2016 The limited effectiveness of the established oximes obidoxime and pralidoxime resulted in ongoing research on novel oximes for the reactivation of acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP). Oximes 45-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 26210933-1 2016 The limited effectiveness of the established oximes obidoxime and pralidoxime resulted in ongoing research on novel oximes for the reactivation of acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP). Obidoxime Chloride 52-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 26210933-1 2016 The limited effectiveness of the established oximes obidoxime and pralidoxime resulted in ongoing research on novel oximes for the reactivation of acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP). pralidoxime 66-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 26210933-1 2016 The limited effectiveness of the established oximes obidoxime and pralidoxime resulted in ongoing research on novel oximes for the reactivation of acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP). Oximes 116-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 26210933-1 2016 The limited effectiveness of the established oximes obidoxime and pralidoxime resulted in ongoing research on novel oximes for the reactivation of acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP). Oximes 116-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 26210933-1 2016 The limited effectiveness of the established oximes obidoxime and pralidoxime resulted in ongoing research on novel oximes for the reactivation of acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP). Organophosphorus Compounds 188-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 26210933-1 2016 The limited effectiveness of the established oximes obidoxime and pralidoxime resulted in ongoing research on novel oximes for the reactivation of acetylcholinesterase (AChE) inhibited by organophosphorus compounds (OP). Organophosphorus Compounds 188-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 26210933-2 2016 In order to get more insight into the ability of bispyridinium oximes to reactivate human AChE inhibited by structurally different OP the reactivation kinetics of 31 compounds was determined with tabun-, cyclosarin- and paraoxon-inhibited AChE under identical experimental conditions. bispyridinium oximes 49-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 26210933-2 2016 In order to get more insight into the ability of bispyridinium oximes to reactivate human AChE inhibited by structurally different OP the reactivation kinetics of 31 compounds was determined with tabun-, cyclosarin- and paraoxon-inhibited AChE under identical experimental conditions. cyclohexyl methylphosphonofluoridate 204-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 26210933-4 2016 Several oximes with superior reactivating potency towards selective OP-AChE conjugates were identified but none of the tested oximes can be considered as a broad spectrum reactivator. Oximes 8-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 26754356-6 2016 Good orthogonality (>0.9) separation was achieved and three AChE inhibitors (tiapride, amisulpride, and lamotrigine), used as antipsychotic medicines, were identified and confirmed by two-dimensional retention alignment as well as their AChE inhibition activity. Tiapride Hydrochloride 80-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 26754356-6 2016 Good orthogonality (>0.9) separation was achieved and three AChE inhibitors (tiapride, amisulpride, and lamotrigine), used as antipsychotic medicines, were identified and confirmed by two-dimensional retention alignment as well as their AChE inhibition activity. Amisulpride 90-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 26754356-6 2016 Good orthogonality (>0.9) separation was achieved and three AChE inhibitors (tiapride, amisulpride, and lamotrigine), used as antipsychotic medicines, were identified and confirmed by two-dimensional retention alignment as well as their AChE inhibition activity. Lamotrigine 107-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 26754356-6 2016 Good orthogonality (>0.9) separation was achieved and three AChE inhibitors (tiapride, amisulpride, and lamotrigine), used as antipsychotic medicines, were identified and confirmed by two-dimensional retention alignment as well as their AChE inhibition activity. Lamotrigine 107-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 240-244 27158324-6 2016 The AChE inhibitor, donepezil, is proven to strengthen cognitive functions and appears effective in treating moderate to severe AD patients. Donepezil 20-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 26795115-3 2016 Particularly, the AChE inhibition potency of compound 5k (IC50 1.9muM) was even 5-fold higher than that of galantamine. Galantamine 107-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 26752094-3 2016 Compound 2-(naphthalen-1-yl)-7-(8-(pyrrolidin-1-yl)octyloxy)-4H-chromen-4-one (5q) showed the best inhibitory activity (IC50, 0.64muM for AChE and 0.42muM for BChE) which were better than our previously reported compounds and the commercially available cholinergic agent Rivastigmine. 2-(naphthalen-1-yl)-7-(8-(pyrrolidin-1-yl)octyloxy)-4h-chromen-4-one 9-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 26752094-3 2016 Compound 2-(naphthalen-1-yl)-7-(8-(pyrrolidin-1-yl)octyloxy)-4H-chromen-4-one (5q) showed the best inhibitory activity (IC50, 0.64muM for AChE and 0.42muM for BChE) which were better than our previously reported compounds and the commercially available cholinergic agent Rivastigmine. CHEMBL3739943 79-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 26752094-5 2016 Furthermore, molecular modeling study showed that 5q targeted both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. Aminosalicylic Acid 132-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 26875979-6 2016 O-{4-Chloro-2-[(4-chlorophenyl)carbamoyl]phenyl} dimethylcarbamothioate was identified as the most effective AChE inhibitor (IC50 = 38.98 microM), while 2-(phenylcarbamoyl)phenyl diphenylcarbamate produced the lowest IC50 value for BChE (1.60 microM). o-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl} dimethylcarbamothioate 0-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 26646154-3 2016 The newly prepared AChE inhibitors (bis-quinolinium and quinolinium compounds) possess a positive charge in the molecule which ensures that anti-AChE action is restricted to peripheral effect. bis-quinolinium 36-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 26646154-3 2016 The newly prepared AChE inhibitors (bis-quinolinium and quinolinium compounds) possess a positive charge in the molecule which ensures that anti-AChE action is restricted to peripheral effect. bis-quinolinium 36-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 26646154-3 2016 The newly prepared AChE inhibitors (bis-quinolinium and quinolinium compounds) possess a positive charge in the molecule which ensures that anti-AChE action is restricted to peripheral effect. Quinolinium 40-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 26646154-3 2016 The newly prepared AChE inhibitors (bis-quinolinium and quinolinium compounds) possess a positive charge in the molecule which ensures that anti-AChE action is restricted to peripheral effect. Quinolinium 40-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 26646154-10 2016 Commonly prescribed carbamates have many severe side effects related to AChE carbamylation. Carbamates 20-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 26646154-12 2016 Unlike carbamates, these new compounds target AChE via apparent pi-pi or pi-cationic interaction aside at the AChE catalytic site. Carbamates 7-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 26646154-12 2016 Unlike carbamates, these new compounds target AChE via apparent pi-pi or pi-cationic interaction aside at the AChE catalytic site. Carbamates 7-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 26621777-3 2016 This study evaluates the ability of pure taxodione and extracts obtained from the S. austriaca hairy roots and roots from field-grown plants to inhibit human acetylcholinesterase and butyrylcholinesterase. taxodione 41-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-178 26621777-6 2016 The highest activity towards human acetylcholinesterase was demonstrated by taxodione (IC50 = 54.84 microg ml(-1)). taxodione 76-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 26735910-0 2016 Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer"s disease. cardanol 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 26735910-3 2016 On the basis of these findings and in connection with our previous studies on cardanol derivatives as acetylcholinesterase (AChE) inhibitors, we designed a novel series of analogues by including a protonable amino moiety belonging to different systems. cardanol 78-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 26735910-3 2016 On the basis of these findings and in connection with our previous studies on cardanol derivatives as acetylcholinesterase (AChE) inhibitors, we designed a novel series of analogues by including a protonable amino moiety belonging to different systems. cardanol 78-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 26735910-3 2016 On the basis of these findings and in connection with our previous studies on cardanol derivatives as acetylcholinesterase (AChE) inhibitors, we designed a novel series of analogues by including a protonable amino moiety belonging to different systems. amino 208-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 26513558-1 2016 A new mesoporous silica protected plasmonic photocatalyst, Au/BiOCl@mSiO2, was prepared by a modified AcHE method and a subsequent UV light induced photodeposition process. Silicon Dioxide 17-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 26513558-1 2016 A new mesoporous silica protected plasmonic photocatalyst, Au/BiOCl@mSiO2, was prepared by a modified AcHE method and a subsequent UV light induced photodeposition process. msio2 68-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 26875979-1 2016 Based on the presence of carbamoyl moiety, twenty salicylanilide N,N-disubstituted (thio)carbamates were investigated using Ellman"s method for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Carbamoyl 25-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-189 26875979-1 2016 Based on the presence of carbamoyl moiety, twenty salicylanilide N,N-disubstituted (thio)carbamates were investigated using Ellman"s method for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Carbamoyl 25-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 191-195 26875979-1 2016 Based on the presence of carbamoyl moiety, twenty salicylanilide N,N-disubstituted (thio)carbamates were investigated using Ellman"s method for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). salicylanilide n,n-disubstituted (thio)carbamates 50-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-189 26875979-1 2016 Based on the presence of carbamoyl moiety, twenty salicylanilide N,N-disubstituted (thio)carbamates were investigated using Ellman"s method for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). salicylanilide n,n-disubstituted (thio)carbamates 50-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 191-195 26875979-4 2016 All of the (thio)carbamates produced a stronger inhibition of AChE than rivastigmine, and five of them inhibited BChE more effectively than both established drugs rivastigmine and galantamine. Thiocarbamates 11-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 26731630-0 2016 Steric and Dynamic Parameters Influencing In Situ Cycloadditions to Form Triazole Inhibitors with Crystalline Acetylcholinesterase. Triazoles 73-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 26731630-2 2016 These features launched AChE as a reaction vessel for in situ click-chemistry synthesis of high-affinity TZ2PA6 and TZ2PA5 inhibitors, forming a syn-triazole upon cycloaddition within the gorge from alkyne and azide reactants bound at the two sites, respectively. Alkynes 199-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 26731630-2 2016 These features launched AChE as a reaction vessel for in situ click-chemistry synthesis of high-affinity TZ2PA6 and TZ2PA5 inhibitors, forming a syn-triazole upon cycloaddition within the gorge from alkyne and azide reactants bound at the two sites, respectively. Azides 210-215 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 26731630-5 2016 The structures reveal motions of residue His447 in the active site and, unprecedentedly, residue Tyr341 at the gorge mouth, associated with TZ2 binding and coordinated with other side chain motions in the gorge that may guide AChE toward a transient state favoring syn-triazole formation. Triazoles 269-277 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-230 26731630-6 2016 Despite precursor binding to crystalline AChE, coupling of rapid electric field fluctuations in the gorge with proper alignments of the azide and alkyne reactants to form the triazole remains a likely limiting step. Azides 136-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 26731630-6 2016 Despite precursor binding to crystalline AChE, coupling of rapid electric field fluctuations in the gorge with proper alignments of the azide and alkyne reactants to form the triazole remains a likely limiting step. Alkynes 146-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 26731630-6 2016 Despite precursor binding to crystalline AChE, coupling of rapid electric field fluctuations in the gorge with proper alignments of the azide and alkyne reactants to form the triazole remains a likely limiting step. Triazoles 175-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 26861273-2 2016 Currently, the only strategy for palliative treatment of AD is to inhibit acetylcholinesterase (AChE) in order to increase the concentration of acetylcholine in the synaptic cleft. Acetylcholine 74-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 26861273-4 2016 It is known that AChE has two binding sites: the peripheral site, responsible for the interactions with Abeta, and the catalytic site, related with acetylcholine hydrolysis. Acetylcholine 148-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 26861273-5 2016 In this work, we reported the synthesis and biological evaluation of a library of new tacrine-donepezil hybrids, as a potential dual binding site AChE inhibitor, containing a triazole-quinoline system. Tacrine 86-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 26861273-5 2016 In this work, we reported the synthesis and biological evaluation of a library of new tacrine-donepezil hybrids, as a potential dual binding site AChE inhibitor, containing a triazole-quinoline system. Donepezil 94-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 26861273-5 2016 In this work, we reported the synthesis and biological evaluation of a library of new tacrine-donepezil hybrids, as a potential dual binding site AChE inhibitor, containing a triazole-quinoline system. Triazoles 175-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 26861273-5 2016 In this work, we reported the synthesis and biological evaluation of a library of new tacrine-donepezil hybrids, as a potential dual binding site AChE inhibitor, containing a triazole-quinoline system. quinoline 184-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 26861273-9 2016 These results are quite interesting since the triazole-quinoline system is a new structural scaffold for AChE inhibitors. Triazoles 46-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 26861273-9 2016 These results are quite interesting since the triazole-quinoline system is a new structural scaffold for AChE inhibitors. quinoline 55-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 26839417-1 2016 A successful prescription is presented for acetylcholinesterase physically adsorbed on to a mesoporous silicon surface, with a promising hydrolytic response towards acetylthiocholine iodide. Silicon 103-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 26839417-1 2016 A successful prescription is presented for acetylcholinesterase physically adsorbed on to a mesoporous silicon surface, with a promising hydrolytic response towards acetylthiocholine iodide. acetylthiocholine iodide 165-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 26839417-7 2016 On the basis of these findings, it was believed that the porous silicon-immobilized enzyme could be exploited as a reusable biocatalyst and for screening of acetylcholinesterase inhibitors from crude plant extracts and synthesized organic compounds. Silicon 64-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-177 26620258-0 2016 Involvement of acetylcholinesterase and protein kinase C in the protective effect of caffeine against beta-amyloid-induced alterations in red blood cells. Caffeine 85-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 26611369-1 2016 A novel bio-analytical method has been devised based on the change in catalytic activity of acetylcholinesterase (AChE) enzyme induced by captan, carbosulfan, 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and pentachlorophenol (PCP) for the investigation of inhibition efficiency and sensitivity using Pt/ZnO/AChE/Chitosan bioelectrode. Captan 138-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 26611369-1 2016 A novel bio-analytical method has been devised based on the change in catalytic activity of acetylcholinesterase (AChE) enzyme induced by captan, carbosulfan, 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and pentachlorophenol (PCP) for the investigation of inhibition efficiency and sensitivity using Pt/ZnO/AChE/Chitosan bioelectrode. Captan 138-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 26611369-1 2016 A novel bio-analytical method has been devised based on the change in catalytic activity of acetylcholinesterase (AChE) enzyme induced by captan, carbosulfan, 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and pentachlorophenol (PCP) for the investigation of inhibition efficiency and sensitivity using Pt/ZnO/AChE/Chitosan bioelectrode. Captan 138-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 303-307 26611369-1 2016 A novel bio-analytical method has been devised based on the change in catalytic activity of acetylcholinesterase (AChE) enzyme induced by captan, carbosulfan, 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and pentachlorophenol (PCP) for the investigation of inhibition efficiency and sensitivity using Pt/ZnO/AChE/Chitosan bioelectrode. carbosulfan 146-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 26611369-1 2016 A novel bio-analytical method has been devised based on the change in catalytic activity of acetylcholinesterase (AChE) enzyme induced by captan, carbosulfan, 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and pentachlorophenol (PCP) for the investigation of inhibition efficiency and sensitivity using Pt/ZnO/AChE/Chitosan bioelectrode. carbosulfan 146-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 26611369-1 2016 A novel bio-analytical method has been devised based on the change in catalytic activity of acetylcholinesterase (AChE) enzyme induced by captan, carbosulfan, 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and pentachlorophenol (PCP) for the investigation of inhibition efficiency and sensitivity using Pt/ZnO/AChE/Chitosan bioelectrode. carbosulfan 146-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 303-307 26611369-1 2016 A novel bio-analytical method has been devised based on the change in catalytic activity of acetylcholinesterase (AChE) enzyme induced by captan, carbosulfan, 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and pentachlorophenol (PCP) for the investigation of inhibition efficiency and sensitivity using Pt/ZnO/AChE/Chitosan bioelectrode. Polychlorinated Dibenzodioxins 159-191 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 26611369-1 2016 A novel bio-analytical method has been devised based on the change in catalytic activity of acetylcholinesterase (AChE) enzyme induced by captan, carbosulfan, 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and pentachlorophenol (PCP) for the investigation of inhibition efficiency and sensitivity using Pt/ZnO/AChE/Chitosan bioelectrode. Polychlorinated Dibenzodioxins 159-191 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 26611369-1 2016 A novel bio-analytical method has been devised based on the change in catalytic activity of acetylcholinesterase (AChE) enzyme induced by captan, carbosulfan, 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and pentachlorophenol (PCP) for the investigation of inhibition efficiency and sensitivity using Pt/ZnO/AChE/Chitosan bioelectrode. Polychlorinated Dibenzodioxins 159-191 acetylcholinesterase (Cartwright blood group) Homo sapiens 303-307 26611369-1 2016 A novel bio-analytical method has been devised based on the change in catalytic activity of acetylcholinesterase (AChE) enzyme induced by captan, carbosulfan, 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and pentachlorophenol (PCP) for the investigation of inhibition efficiency and sensitivity using Pt/ZnO/AChE/Chitosan bioelectrode. Polychlorinated Dibenzodioxins 193-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 26611369-1 2016 A novel bio-analytical method has been devised based on the change in catalytic activity of acetylcholinesterase (AChE) enzyme induced by captan, carbosulfan, 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and pentachlorophenol (PCP) for the investigation of inhibition efficiency and sensitivity using Pt/ZnO/AChE/Chitosan bioelectrode. Polychlorinated Dibenzodioxins 193-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 26611369-1 2016 A novel bio-analytical method has been devised based on the change in catalytic activity of acetylcholinesterase (AChE) enzyme induced by captan, carbosulfan, 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and pentachlorophenol (PCP) for the investigation of inhibition efficiency and sensitivity using Pt/ZnO/AChE/Chitosan bioelectrode. Polychlorinated Dibenzodioxins 193-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 303-307 26611369-1 2016 A novel bio-analytical method has been devised based on the change in catalytic activity of acetylcholinesterase (AChE) enzyme induced by captan, carbosulfan, 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and pentachlorophenol (PCP) for the investigation of inhibition efficiency and sensitivity using Pt/ZnO/AChE/Chitosan bioelectrode. Pentachlorophenol 203-220 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 26611369-1 2016 A novel bio-analytical method has been devised based on the change in catalytic activity of acetylcholinesterase (AChE) enzyme induced by captan, carbosulfan, 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and pentachlorophenol (PCP) for the investigation of inhibition efficiency and sensitivity using Pt/ZnO/AChE/Chitosan bioelectrode. Pentachlorophenol 203-220 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 26611369-1 2016 A novel bio-analytical method has been devised based on the change in catalytic activity of acetylcholinesterase (AChE) enzyme induced by captan, carbosulfan, 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and pentachlorophenol (PCP) for the investigation of inhibition efficiency and sensitivity using Pt/ZnO/AChE/Chitosan bioelectrode. Pentachlorophenol 222-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 26611369-1 2016 A novel bio-analytical method has been devised based on the change in catalytic activity of acetylcholinesterase (AChE) enzyme induced by captan, carbosulfan, 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and pentachlorophenol (PCP) for the investigation of inhibition efficiency and sensitivity using Pt/ZnO/AChE/Chitosan bioelectrode. Pentachlorophenol 222-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 26611369-1 2016 A novel bio-analytical method has been devised based on the change in catalytic activity of acetylcholinesterase (AChE) enzyme induced by captan, carbosulfan, 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and pentachlorophenol (PCP) for the investigation of inhibition efficiency and sensitivity using Pt/ZnO/AChE/Chitosan bioelectrode. Zinc Oxide 299-302 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 26611369-1 2016 A novel bio-analytical method has been devised based on the change in catalytic activity of acetylcholinesterase (AChE) enzyme induced by captan, carbosulfan, 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and pentachlorophenol (PCP) for the investigation of inhibition efficiency and sensitivity using Pt/ZnO/AChE/Chitosan bioelectrode. Zinc Oxide 299-302 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 26611369-4 2016 The maximum inhibition of AChE enzyme by captan was about 100 %, which was much higher than that of TCDD (72.7 %), PCP (68.1 %) and carbosulfan (47.7 %). Captan 41-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 26611369-4 2016 The maximum inhibition of AChE enzyme by captan was about 100 %, which was much higher than that of TCDD (72.7 %), PCP (68.1 %) and carbosulfan (47.7 %). Polychlorinated Dibenzodioxins 100-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 26611369-4 2016 The maximum inhibition of AChE enzyme by captan was about 100 %, which was much higher than that of TCDD (72.7 %), PCP (68.1 %) and carbosulfan (47.7 %). Pentachlorophenol 115-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 26611369-4 2016 The maximum inhibition of AChE enzyme by captan was about 100 %, which was much higher than that of TCDD (72.7 %), PCP (68.1 %) and carbosulfan (47.7 %). carbosulfan 132-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 26747974-2 2016 Both oximes are very potent reactivators of organophosphate-inhibited AChE. Oximes 5-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 26747974-2 2016 Both oximes are very potent reactivators of organophosphate-inhibited AChE. Organophosphates 44-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 26747974-9 2016 Hence, the interaction of K027 and K203 oxime-type AChE reactivators with human liver microsomal CYP enzymes does not seem to be of prominent clinical importance and both compounds could be safely used in this respect as antidotes with low risk of drug interactions. k203 oxime 35-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 26838742-6 2016 However, the treatment with BBR enhanced the glucose uptake, increased the expression of alpha7nAChR protein and inhibited AChE activity. Berberine 28-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 26541777-7 2016 METHODS: Phenyl 4-iodophenylcarbamate was synthesized and evaluated for binding potency toward acetylcholinesterase and butyrylcholinesterase using enzyme kinetic analysis. phenyl 4-iodophenylcarbamate 9-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 26805806-0 2016 Graveoline Analogs Exhibiting Selective Acetylcholinesterase Inhibitory Activity as Potential Lead Compounds for the Treatment of Alzheimer"s Disease. graveoline 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 26805806-1 2016 This study designed and synthesized a series of new graveoline analogs on the basis of the structural characteristics of acetylcholinesterase (AChE) dual-site inhibitors. graveoline 52-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 26805806-1 2016 This study designed and synthesized a series of new graveoline analogs on the basis of the structural characteristics of acetylcholinesterase (AChE) dual-site inhibitors. graveoline 52-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 26805806-3 2016 Results showed that the synthesized graveoline analogs displayed stronger inhibitory activity against AChE and higher selectivity than butyrylcholine esterase (BuChE) (Selectivity Index from 45 to 486). graveoline 36-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 26339933-0 2016 Biphasic photoelectrochemical sensing strategy based on in situ formation of CdS quantum dots for highly sensitive detection of acetylcholinesterase activity and inhibition. Cadmium 77-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 26339933-2 2016 Upon the hydrolysis of acetylthiocholine catalyzed by AChE, the product thiocholine stabilizes the in situ formation of CdS QDs in homogenous solution. Acetylthiocholine 23-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 26339933-2 2016 Upon the hydrolysis of acetylthiocholine catalyzed by AChE, the product thiocholine stabilizes the in situ formation of CdS QDs in homogenous solution. Thiocholine 29-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 26339933-2 2016 Upon the hydrolysis of acetylthiocholine catalyzed by AChE, the product thiocholine stabilizes the in situ formation of CdS QDs in homogenous solution. cds qds 120-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 26339933-4 2016 By taking full advantage of the in situ formation of CdS QDs in homogenous solution, this strategy is capable of detecting AChE activity and inhibition in its optimal state. Cadmium 53-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 26339933-6 2016 The inhibition of AChE activity by aldicarb is successfully detected, and the corresponding IC50 is determined to be 13mug/L. Aldicarb 35-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 26875979-6 2016 O-{4-Chloro-2-[(4-chlorophenyl)carbamoyl]phenyl} dimethylcarbamothioate was identified as the most effective AChE inhibitor (IC50 = 38.98 microM), while 2-(phenylcarbamoyl)phenyl diphenylcarbamate produced the lowest IC50 value for BChE (1.60 microM). 2-(phenylcarbamoyl)phenyl diphenylcarbamate 153-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 27682399-3 2016 Active acetylcholinesterase (AChE) catalyzes the hydrolysis of acetylthiocholine into -SH containing thiocholine to replace the NC-dots and trigger the aggregation of AuNPs. Acetylthiocholine 63-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 7-27 27682399-3 2016 Active acetylcholinesterase (AChE) catalyzes the hydrolysis of acetylthiocholine into -SH containing thiocholine to replace the NC-dots and trigger the aggregation of AuNPs. Acetylthiocholine 63-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 27682399-3 2016 Active acetylcholinesterase (AChE) catalyzes the hydrolysis of acetylthiocholine into -SH containing thiocholine to replace the NC-dots and trigger the aggregation of AuNPs. Thiocholine 69-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 7-27 27682399-3 2016 Active acetylcholinesterase (AChE) catalyzes the hydrolysis of acetylthiocholine into -SH containing thiocholine to replace the NC-dots and trigger the aggregation of AuNPs. Thiocholine 69-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 27682399-4 2016 In the presence of paraoxon, the activity of AChE is inhibited, and thus preventing the generation of thiocholine, causing fewer NC-dots to be replaced. Paraoxon 19-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 27682399-4 2016 In the presence of paraoxon, the activity of AChE is inhibited, and thus preventing the generation of thiocholine, causing fewer NC-dots to be replaced. Thiocholine 102-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 25365355-0 2016 Acetylcholinesterase immobilized onto PEI-coated silica nanoparticles. Silicon Dioxide 49-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 25365355-9 2016 The storage stability of acetylcholinesterase was increased when immobilized onto the novel PEI-coated silica nanoparticles. Silicon Dioxide 103-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 25402624-4 2016 This study explores the molecular interactions between AChE and SGLT2 with a new US Food and Drug Administration approved antidiabetic drug Forxiga (dapagliflozin) to explore a possible link between the treatments of AD and diabetes. dapagliflozin 149-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 25402624-6 2016 Hydrophobic and cation-pi interactions play an important role in the correct positioning of dapagliflozin within the catalytic site (CAS) of SGLT2 and AChE enzymes to permit docking. dapagliflozin 92-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 25402624-7 2016 Free energy of binding (DeltaG) of "dapagliflozin-SGLT2" and "dapagliflozin-CAS domain of AChE" interactions was found to be -6.25 and -6.28 kcal/mol, respectively. dapagliflozin 36-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 25402624-7 2016 Free energy of binding (DeltaG) of "dapagliflozin-SGLT2" and "dapagliflozin-CAS domain of AChE" interactions was found to be -6.25 and -6.28 kcal/mol, respectively. dapagliflozin 62-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 25402624-8 2016 Hence, dapagliflozin might act as a potent dual inhibitor of SGLT2 and AChE. dapagliflozin 7-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 26270602-2 2016 Here, we consider a bispyridinium drug, namely, ortho-7 in three different structures of AChE, with and without complexation with organophosphorus (OP) compounds for detailed investigation using all atom molecular dynamics simulation. bispyridinium 20-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 26270602-2 2016 Here, we consider a bispyridinium drug, namely, ortho-7 in three different structures of AChE, with and without complexation with organophosphorus (OP) compounds for detailed investigation using all atom molecular dynamics simulation. ortho-7 48-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 27073702-3 2016 Rivastigmine is a reversible and competitive inhibitor of acetylcholinesterase and butyrylcholinesterase used for symptomatic treatment of Alzheimer dementia and Parkinson"s disease. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 26143664-6 2016 Initiation of donepezil, an acetylcholinesterase inhibitor, resulted in the disappearance of these symptoms and total recovery of the patient to his previous psychosocial levels. Donepezil 14-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 26862533-1 2016 OBJECTIVE: Organophosphorus (OP) compounds are used to control pests, however they can reach the food chain and enter the human body causing serious health problems by means of acetylcholinesterase (AChE) inhibition and oxidative stress (OS). organophosphorus 11-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-197 26862533-1 2016 OBJECTIVE: Organophosphorus (OP) compounds are used to control pests, however they can reach the food chain and enter the human body causing serious health problems by means of acetylcholinesterase (AChE) inhibition and oxidative stress (OS). organophosphorus 11-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-203 27581632-1 2016 A series of pyridinium salts bearing alkylphenyl groups at 1 position and hydrazone structure at 4 position of the pyridinium ring were synthesized and evaluated for the inhibition of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes. pyridinium salts 12-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-209 27581632-1 2016 A series of pyridinium salts bearing alkylphenyl groups at 1 position and hydrazone structure at 4 position of the pyridinium ring were synthesized and evaluated for the inhibition of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes. pyridinium salts 12-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-215 27581632-1 2016 A series of pyridinium salts bearing alkylphenyl groups at 1 position and hydrazone structure at 4 position of the pyridinium ring were synthesized and evaluated for the inhibition of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes. pyridine 12-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-209 27581632-1 2016 A series of pyridinium salts bearing alkylphenyl groups at 1 position and hydrazone structure at 4 position of the pyridinium ring were synthesized and evaluated for the inhibition of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes. pyridine 12-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-215 27581632-3 2016 All compounds displayed considerable AChE and BuChE inhibitory activity and some of the compounds manifested remarkable anti-AChE activity compared to the reference compound, galantamine. Galantamine 175-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 27581632-4 2016 Among the title compounds, the series including benzofuran aromatic ring exhibited the best inhibitory activity both on AChE and BuChE enzymes. benzofuran 48-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 26996169-0 2016 In Silico Analysis of Green Tea Polyphenols as Inhibitors of AChE and BChE Enzymes in Alzheimer"s Disease Treatment. Polyphenols 32-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 27767976-3 2016 It is also known that binding of acetylcholine (ACh) with AChE on erythrocyte membrane initiates a signal transduction mechanism that stimulates nitric oxide (NO) efflux. Acetylcholine 33-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 27767976-3 2016 It is also known that binding of acetylcholine (ACh) with AChE on erythrocyte membrane initiates a signal transduction mechanism that stimulates nitric oxide (NO) efflux. Acetylcholine 48-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 27767976-3 2016 It is also known that binding of acetylcholine (ACh) with AChE on erythrocyte membrane initiates a signal transduction mechanism that stimulates nitric oxide (NO) efflux. Nitric Oxide 145-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 27814291-5 2016 Furthermore, since mechanical properties of RBC membrane are regulated by a number of molecular components of signalling and/or regulatory pathways, of these, particular interest has been addressed toward Nitric Oxide (NO) metabolism, due to its dependence to AChE. Nitric Oxide 205-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 260-264 27814293-6 2016 Erythrocyte suspensions were incubated with the AChE modulators acetylcholine (ACh) and timolol at 10 muM. Acetylcholine 64-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 27697060-7 2016 Both, hydrogen bond and hydrophobic interactions were found to be involved in the proper positioning of these diabetic drugs within the catalytic site (CAS) of AChE and BACE enzymes to permit docking. Hydrogen 6-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 26996169-6 2016 In this study, we selected tea polyphenols of green tea which are reported as AChE and BChE inhibitors used in the treatment of AD. Polyphenols 31-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 26996169-7 2016 The molecular docking results revealed that polyphenols exhibit interactions and inhibit by binding with AChE and BChE. Polyphenols 44-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 26996169-8 2016 The amount of energy to bind with AChE and BChE needed by Epigallocatechin-3-gallate was lowest at about -14.45 and -13.30 kcal/mol, respectively. epigallocatechin gallate 58-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 26996169-10 2016 The present docking study suggests that tea polyphenols inhibit AChE as well as BChE and enhance the cholinergic neurotransmission by prolonging the time. Polyphenols 44-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 26813123-4 2016 ACh present at the synaptic cleft is promptly hydrolyzed by the enzyme acetylcholinesterase (AChE), forming acetate and choline, which is recycled into the presynaptic nerve terminal by the high-affinity choline transporter (CHT1). Acetylcholine 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 27040140-1 2016 The serine hydrolase butyrylcholinesterase (BChE), like the related enzyme acetylcholinesterase (AChE), co-regulates metabolism of the neurotransmitter acetylcholine. Serine 4-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 27040140-1 2016 The serine hydrolase butyrylcholinesterase (BChE), like the related enzyme acetylcholinesterase (AChE), co-regulates metabolism of the neurotransmitter acetylcholine. Serine 4-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 27040140-1 2016 The serine hydrolase butyrylcholinesterase (BChE), like the related enzyme acetylcholinesterase (AChE), co-regulates metabolism of the neurotransmitter acetylcholine. Acetylcholine 75-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 26502813-2 2016 Two novel enantiopure rhein-huprine hybrids ((+)-1 and (-)-1) exhibit potent inhibitory effects against human acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), BACE-1 and both Abeta and tau antiaggregation activity in vitro and reduction on the amyloid precursor protein (APP) processing in vivo. huprine 28-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 26502813-2 2016 Two novel enantiopure rhein-huprine hybrids ((+)-1 and (-)-1) exhibit potent inhibitory effects against human acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), BACE-1 and both Abeta and tau antiaggregation activity in vitro and reduction on the amyloid precursor protein (APP) processing in vivo. huprine 28-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 26813123-4 2016 ACh present at the synaptic cleft is promptly hydrolyzed by the enzyme acetylcholinesterase (AChE), forming acetate and choline, which is recycled into the presynaptic nerve terminal by the high-affinity choline transporter (CHT1). Acetylcholine 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 26813123-4 2016 ACh present at the synaptic cleft is promptly hydrolyzed by the enzyme acetylcholinesterase (AChE), forming acetate and choline, which is recycled into the presynaptic nerve terminal by the high-affinity choline transporter (CHT1). Acetates 108-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 26813123-4 2016 ACh present at the synaptic cleft is promptly hydrolyzed by the enzyme acetylcholinesterase (AChE), forming acetate and choline, which is recycled into the presynaptic nerve terminal by the high-affinity choline transporter (CHT1). Acetates 108-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 26813123-4 2016 ACh present at the synaptic cleft is promptly hydrolyzed by the enzyme acetylcholinesterase (AChE), forming acetate and choline, which is recycled into the presynaptic nerve terminal by the high-affinity choline transporter (CHT1). Choline 77-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 26813123-4 2016 ACh present at the synaptic cleft is promptly hydrolyzed by the enzyme acetylcholinesterase (AChE), forming acetate and choline, which is recycled into the presynaptic nerve terminal by the high-affinity choline transporter (CHT1). Choline 120-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 26813123-4 2016 ACh present at the synaptic cleft is promptly hydrolyzed by the enzyme acetylcholinesterase (AChE), forming acetate and choline, which is recycled into the presynaptic nerve terminal by the high-affinity choline transporter (CHT1). Choline 120-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 27586843-9 2016 Oral administration of 1-phenylisatin has significantly recuperated 2VO induced impairment in learning-memory, an increase in TBARS, GSH, CAT, SOD, mitochondrial activity with a significant reduction in AChE activity and brain damage. 1-Phenylisatin 23-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 203-207 27189349-11 2016 Treatment with bosentan has also restored 2K1C induced a rise in brain TBARS, AChE, MPO activity, reduction in brain GSH, SOD and CAT as well as brain damage. Bosentan 15-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 26799963-1 2016 INTRODUCTION: Acetylcholinesterase inhibitors (neostigmine, edrophonium) and encapsulating agents (sugammadex and calabadion) can be used to reverse residual neuromuscular blockade (NMB). Neostigmine 47-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 26588065-2 2016 In vitro studies revealed that most of these compounds exhibited high inhibitory activity on acetylcholinesterase (AChE), with IC50 values ranging from 0.003 to 0.357 muM which is 2-220 folds more potent than the positive control, galantamine. Galantamine 231-242 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 26588065-2 2016 In vitro studies revealed that most of these compounds exhibited high inhibitory activity on acetylcholinesterase (AChE), with IC50 values ranging from 0.003 to 0.357 muM which is 2-220 folds more potent than the positive control, galantamine. Galantamine 231-242 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 26588065-3 2016 Their inhibition selectivity against AChE over butyrylcholinesterase (BuChE) has increased about 194 fold compared with galantamine. Galantamine 120-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 26588065-5 2016 Specifically, the most potent AChE inhibitor 6n (IC50 0.003 +- 0.0007 muM) has an excellent antioxidant profile as determined by the ABTS method (IC50 7.98 +- 0.77 muM). 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid 133-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 26588065-8 2016 Accordingly, the molecular modeling study demonstrated that 6m-q with substituted benzyl amido moiety possessed an optimal docking pose with interactions at catalytic active site (CAS) and peripheral anionic site (PAS) of AChE simultaneously and thereby they might prevent aggregation of Abeta induced by AChE. 6m-q 60-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 222-226 26588065-8 2016 Accordingly, the molecular modeling study demonstrated that 6m-q with substituted benzyl amido moiety possessed an optimal docking pose with interactions at catalytic active site (CAS) and peripheral anionic site (PAS) of AChE simultaneously and thereby they might prevent aggregation of Abeta induced by AChE. 6m-q 60-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 305-309 26588065-8 2016 Accordingly, the molecular modeling study demonstrated that 6m-q with substituted benzyl amido moiety possessed an optimal docking pose with interactions at catalytic active site (CAS) and peripheral anionic site (PAS) of AChE simultaneously and thereby they might prevent aggregation of Abeta induced by AChE. benzyl amido 82-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 222-226 26588065-8 2016 Accordingly, the molecular modeling study demonstrated that 6m-q with substituted benzyl amido moiety possessed an optimal docking pose with interactions at catalytic active site (CAS) and peripheral anionic site (PAS) of AChE simultaneously and thereby they might prevent aggregation of Abeta induced by AChE. benzyl amido 82-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 305-309 27642355-4 2016 Molecular Docking Software (MOE) was used to discover molecular sites of action between biatractylolide and AChE protein by regular molecular docking approaches. biatractylolide 88-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 27642355-5 2016 Moreover, biatractylolide downregulated the expression of AChE of MEF and 293T cells in a dose-dependent manner. biatractylolide 10-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 27642355-6 2016 These results demonstrated that the molecular mechanisms of inhibitory activities of biatractylolide on AChE are not only through binding to AChE, but also via reducing AChE expression by inhibiting the activity of GSK3beta. biatractylolide 85-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 27642355-6 2016 These results demonstrated that the molecular mechanisms of inhibitory activities of biatractylolide on AChE are not only through binding to AChE, but also via reducing AChE expression by inhibiting the activity of GSK3beta. biatractylolide 85-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 27642355-6 2016 These results demonstrated that the molecular mechanisms of inhibitory activities of biatractylolide on AChE are not only through binding to AChE, but also via reducing AChE expression by inhibiting the activity of GSK3beta. biatractylolide 85-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 26799963-1 2016 INTRODUCTION: Acetylcholinesterase inhibitors (neostigmine, edrophonium) and encapsulating agents (sugammadex and calabadion) can be used to reverse residual neuromuscular blockade (NMB). Edrophonium 60-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 25697270-6 2016 In this study, some trimethoxyindane derivatives were investigated as inhibitors against the cytosolic hCA I and II isoenzymes, and AChE enzyme. trimethoxyindane 20-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 27075164-0 2016 The synthesis of some beta-lactams and investigation of their metal-chelating activity, carbonic anhydrase and acetylcholinesterase inhibition profiles. beta-Lactams 22-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 25798685-1 2016 The synthesis, the antioxidative properties and the lipoxygenase (LOX) and acetylcholinesterase (AChE) inhibition of a number of 4-hydroxy-chalcones diversely substituted as well as of a series of bis-chalcones ether derivatives are reported. 4-hydroxy-chalcones 129-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 27075164-6 2016 Also, tacrine used as standard AChE inhibitor showed Ki value of 5.70 nM against AChE. Tacrine 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 27075164-6 2016 Also, tacrine used as standard AChE inhibitor showed Ki value of 5.70 nM against AChE. Tacrine 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 25893707-0 2016 Acetylcholinesterase and carbonic anhydrase isoenzymes I and II inhibition profiles of taxifolin. taxifolin 87-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-63 25893707-6 2016 For acetylcholinesterase enzyme (AChE) inhibition, K(i) parameter of taxifolin was determined to be 16.7 nM. taxifolin 69-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-31 25893707-6 2016 For acetylcholinesterase enzyme (AChE) inhibition, K(i) parameter of taxifolin was determined to be 16.7 nM. taxifolin 69-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 25893707-7 2016 These results clearly show that taxifolin inhibited both CA isoenzymes and AChE at the nM levels. taxifolin 32-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 25798685-1 2016 The synthesis, the antioxidative properties and the lipoxygenase (LOX) and acetylcholinesterase (AChE) inhibition of a number of 4-hydroxy-chalcones diversely substituted as well as of a series of bis-chalcones ether derivatives are reported. 4-hydroxy-chalcones 129-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 26427931-2 2016 The novel compounds were tested in vitro on the model of tabun-, paraoxon-, methylparaoxon- and DFP-inhibited human erythrocyte AChE. Paraoxon 65-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 27476673-4 2016 The AChE/BChE selectivity for each carbamate was calculated. Carbamates 35-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 27476673-5 2016 These values varied from 0.50 to 9.46, two carbamate derivatives inhibited only AChE selectively. Carbamates 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 27594053-0 2016 New N,N-dimethylcarbamate inhibitors of acetylcholinesterase: design synthesis and biological evaluation. N,N-dimethylcarbamate 4-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 27594053-1 2016 A series of N,N-dimethylcarbamates containing a N,N-dibenzylamino moiety was synthesized and tested to evaluate their ability to inhibit Acetylcholinesterase (AChE). N,N-dimethylcarbamate 12-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 27594053-1 2016 A series of N,N-dimethylcarbamates containing a N,N-dibenzylamino moiety was synthesized and tested to evaluate their ability to inhibit Acetylcholinesterase (AChE). N,N-dimethylcarbamate 12-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 27594053-1 2016 A series of N,N-dimethylcarbamates containing a N,N-dibenzylamino moiety was synthesized and tested to evaluate their ability to inhibit Acetylcholinesterase (AChE). n,n-dibenzylamino 48-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 27594053-1 2016 A series of N,N-dimethylcarbamates containing a N,N-dibenzylamino moiety was synthesized and tested to evaluate their ability to inhibit Acetylcholinesterase (AChE). n,n-dibenzylamino 48-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 26427931-2 2016 The novel compounds were tested in vitro on the model of tabun-, paraoxon-, methylparaoxon- and DFP-inhibited human erythrocyte AChE. methylparaoxon 76-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 26427931-6 2016 Bisoximes obidoxime and K108 resulted as the best reactivators for paraoxon-, methylparaoxon- and DFP-inhibited AChE. bisoximes 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 26427931-6 2016 Bisoximes obidoxime and K108 resulted as the best reactivators for paraoxon-, methylparaoxon- and DFP-inhibited AChE. Obidoxime Chloride 10-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 26427931-6 2016 Bisoximes obidoxime and K108 resulted as the best reactivators for paraoxon-, methylparaoxon- and DFP-inhibited AChE. phenprobamate 24-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 26427931-6 2016 Bisoximes obidoxime and K108 resulted as the best reactivators for paraoxon-, methylparaoxon- and DFP-inhibited AChE. Paraoxon 67-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 26833077-6 2016 RESULTS: Among them, 3j displayed higher inhibitory activities than reference drug, galanthamine, with IC50 values of 2.05 and 5.77 microM, for AChE and BChE, respectively. Galantamine 84-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 26833077-9 2016 The compound forms strong hydrogen bonding at the peripheral anionic site of AChE whereas on BChE, it had hydrophobic and mild polar interactions. Hydrogen 26-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 28635795-3 2016 To overcome the cholinergic insufficiency, acetylcholinesterase inhibitors (rivastigmine, donepezil and galantamine) are primarily used. Rivastigmine 76-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 26427931-6 2016 Bisoximes obidoxime and K108 resulted as the best reactivators for paraoxon-, methylparaoxon- and DFP-inhibited AChE. methylparaoxon 78-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 26427931-8 2016 Though the novel reactivators did not exceed previously known compounds, they confirmed former SAR findings for xylene-linked AChE reactivators. Xylenes 112-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 27241224-0 2016 Synthesis of diaryl ethers with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions. diaryl ethers 13-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 26368669-1 2015 Tabun-inhibited acetylcholinesterase (AChE) is rather resistant towards reactivation by oximes in vitro while in vivo experiments showed some protection of animals poisoned by this chemical warfare nerve agent after treatment with an oxime and atropine. tabun 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 26368669-1 2015 Tabun-inhibited acetylcholinesterase (AChE) is rather resistant towards reactivation by oximes in vitro while in vivo experiments showed some protection of animals poisoned by this chemical warfare nerve agent after treatment with an oxime and atropine. tabun 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 26368669-1 2015 Tabun-inhibited acetylcholinesterase (AChE) is rather resistant towards reactivation by oximes in vitro while in vivo experiments showed some protection of animals poisoned by this chemical warfare nerve agent after treatment with an oxime and atropine. Oximes 88-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 26368669-1 2015 Tabun-inhibited acetylcholinesterase (AChE) is rather resistant towards reactivation by oximes in vitro while in vivo experiments showed some protection of animals poisoned by this chemical warfare nerve agent after treatment with an oxime and atropine. Oximes 88-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 26368669-1 2015 Tabun-inhibited acetylcholinesterase (AChE) is rather resistant towards reactivation by oximes in vitro while in vivo experiments showed some protection of animals poisoned by this chemical warfare nerve agent after treatment with an oxime and atropine. Oximes 88-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 26368669-1 2015 Tabun-inhibited acetylcholinesterase (AChE) is rather resistant towards reactivation by oximes in vitro while in vivo experiments showed some protection of animals poisoned by this chemical warfare nerve agent after treatment with an oxime and atropine. Oximes 88-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 26368669-1 2015 Tabun-inhibited acetylcholinesterase (AChE) is rather resistant towards reactivation by oximes in vitro while in vivo experiments showed some protection of animals poisoned by this chemical warfare nerve agent after treatment with an oxime and atropine. Atropine 244-252 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 26368669-1 2015 Tabun-inhibited acetylcholinesterase (AChE) is rather resistant towards reactivation by oximes in vitro while in vivo experiments showed some protection of animals poisoned by this chemical warfare nerve agent after treatment with an oxime and atropine. Atropine 244-252 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 26368669-2 2015 In addition, AChE inhibited by close tabun analogues, N,N-diethyltabun and N,N-di-n-propyltabun was completely resistant towards reactivation by oximes. n,n-diethyltabun 54-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 26368669-2 2015 In addition, AChE inhibited by close tabun analogues, N,N-diethyltabun and N,N-di-n-propyltabun was completely resistant towards reactivation by oximes. n,n-di-n-propyltabun 75-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 26368669-2 2015 In addition, AChE inhibited by close tabun analogues, N,N-diethyltabun and N,N-di-n-propyltabun was completely resistant towards reactivation by oximes. Oximes 145-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 26368669-3 2015 In order to get more insight into potential mechanisms of this oxime resistance experiments with these toxic agents and the oximes obidoxime, 2-PAM, MMB-4 and HI-6 were performed utilizing a dynamic model with real-time determination of AChE activity. Oximes 63-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 237-241 26368669-6 2015 N,N-diethyl- and N,N-di-n-propyltabun-inhibited human AChE could not be reactivated by oximes which indicates that the inadequate oxime effect was not due to re-inhibition by phosphonyloximes. n,n-diethyl- and n,n-di-n-propyltabun 0-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 26368669-8 2015 These data give further support to the assumption that an interaction of tabun with residues in the active site gorge of AChE prevents effective reactivation by oximes, a mechanism which may also be the reason for the total oxime resistance of N,N-diethyl- and N,N-di-n-propyltabun-inhibited human AChE. Oximes 161-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 26368669-8 2015 These data give further support to the assumption that an interaction of tabun with residues in the active site gorge of AChE prevents effective reactivation by oximes, a mechanism which may also be the reason for the total oxime resistance of N,N-diethyl- and N,N-di-n-propyltabun-inhibited human AChE. Oximes 161-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 298-302 26368669-8 2015 These data give further support to the assumption that an interaction of tabun with residues in the active site gorge of AChE prevents effective reactivation by oximes, a mechanism which may also be the reason for the total oxime resistance of N,N-diethyl- and N,N-di-n-propyltabun-inhibited human AChE. Oximes 161-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 26368669-8 2015 These data give further support to the assumption that an interaction of tabun with residues in the active site gorge of AChE prevents effective reactivation by oximes, a mechanism which may also be the reason for the total oxime resistance of N,N-diethyl- and N,N-di-n-propyltabun-inhibited human AChE. Oximes 161-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 298-302 26368669-8 2015 These data give further support to the assumption that an interaction of tabun with residues in the active site gorge of AChE prevents effective reactivation by oximes, a mechanism which may also be the reason for the total oxime resistance of N,N-diethyl- and N,N-di-n-propyltabun-inhibited human AChE. n,n-diethyl- 244-256 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 26368669-8 2015 These data give further support to the assumption that an interaction of tabun with residues in the active site gorge of AChE prevents effective reactivation by oximes, a mechanism which may also be the reason for the total oxime resistance of N,N-diethyl- and N,N-di-n-propyltabun-inhibited human AChE. n,n-di-n-propyltabun 261-281 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 26618211-3 2015 In the present study, we report structure elucidation for 2-5 and the revised NMR assignments for asteltoxin and demonstrated that avertoxin B (3) is an active inhibitor against human acetylcholinesterase with the IC50 value of 14.9 muM (huperzine A as the positive control had an IC50 of 0.6 muM). avertoxin b 131-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-204 28635795-3 2016 To overcome the cholinergic insufficiency, acetylcholinesterase inhibitors (rivastigmine, donepezil and galantamine) are primarily used. Donepezil 90-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 28635795-3 2016 To overcome the cholinergic insufficiency, acetylcholinesterase inhibitors (rivastigmine, donepezil and galantamine) are primarily used. Galantamine 104-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 26141104-2 2015 Subsequently, an AuNCs@11-MUA-Cu(2+) ensemble-based fluorescent chemosensor, which is amenable to convenient, sensitive, selective, turn-on and real-time assay of acetylcholinesterase (AChE), could be developed by using acetylthiocholine (ATCh) as the substrate. Acetylthiocholine 220-237 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-183 26141104-2 2015 Subsequently, an AuNCs@11-MUA-Cu(2+) ensemble-based fluorescent chemosensor, which is amenable to convenient, sensitive, selective, turn-on and real-time assay of acetylcholinesterase (AChE), could be developed by using acetylthiocholine (ATCh) as the substrate. Acetylthiocholine 220-237 acetylcholinesterase (Cartwright blood group) Homo sapiens 185-189 26141104-2 2015 Subsequently, an AuNCs@11-MUA-Cu(2+) ensemble-based fluorescent chemosensor, which is amenable to convenient, sensitive, selective, turn-on and real-time assay of acetylcholinesterase (AChE), could be developed by using acetylthiocholine (ATCh) as the substrate. Acetylthiocholine 239-243 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-183 26141104-2 2015 Subsequently, an AuNCs@11-MUA-Cu(2+) ensemble-based fluorescent chemosensor, which is amenable to convenient, sensitive, selective, turn-on and real-time assay of acetylcholinesterase (AChE), could be developed by using acetylthiocholine (ATCh) as the substrate. Acetylthiocholine 239-243 acetylcholinesterase (Cartwright blood group) Homo sapiens 185-189 26141104-3 2015 Herein, the sensing ensemble solution exhibits a marvelous fluorescent enhancement in the presence of AChE and ATCh, where AChE hydrolyzes its active substrate ATCh into thiocholine (TCh), and then TCh captures Cu(2+) from the ensemble, accompanied by the conversion from fluorescence off-state to on-state of the AuNCs. Thiocholine 170-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 26141104-3 2015 Herein, the sensing ensemble solution exhibits a marvelous fluorescent enhancement in the presence of AChE and ATCh, where AChE hydrolyzes its active substrate ATCh into thiocholine (TCh), and then TCh captures Cu(2+) from the ensemble, accompanied by the conversion from fluorescence off-state to on-state of the AuNCs. Thiocholine 170-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 26585276-0 2015 Synthesis and comparison of the biological activity of monocyclic phosphonate, difluorophosphonate and phosphate analogs of the natural AChE inhibitor cyclophostin. Phosphates 103-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 26585276-0 2015 Synthesis and comparison of the biological activity of monocyclic phosphonate, difluorophosphonate and phosphate analogs of the natural AChE inhibitor cyclophostin. cyclophostin 151-163 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 26585276-1 2015 New monocyclic phosphate, phosphonate and difluorophosphonate analogs of the natural AChE inhibitor cyclophostin were synthesized and their activity toward human AChE examined. cyclophostin 100-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 26585276-1 2015 New monocyclic phosphate, phosphonate and difluorophosphonate analogs of the natural AChE inhibitor cyclophostin were synthesized and their activity toward human AChE examined. cyclophostin 100-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-166 26642985-5 2015 We obtained finite-temperature sampling by first-principles molecular dynamics for the acylation reaction of acetylcholine catalyzed by acetylcholinesterase. Acetylcholine 109-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 26642212-5 2015 A disproportionately higher frequency of reports of death as an adverse event for rivastigmine, compared to the other acetylcholinesterase inhibiting drugs, was observed in both the FAERS (ROR = 3.42; CI95% = 2.94-3.98; P<0.0001) and CVARD (ROR = 3.67; CI95% = 1.92-7.00; P = 0.001) databases. Rivastigmine 82-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 26494532-1 2015 Organophosphorus compound (OP) tabun is resistant to reactivate by many oxime drugs after the formation of OP-conjugate with AChE. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 26152875-4 2015 In the present study, we examined the inhibitory activity of methanol extracts of different parts of 12 Angelica species against alpha-glucosidase, protein tyrosine phosphatase 1B (PTP1B), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). Methanol 61-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-209 26152875-4 2015 In the present study, we examined the inhibitory activity of methanol extracts of different parts of 12 Angelica species against alpha-glucosidase, protein tyrosine phosphatase 1B (PTP1B), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). Methanol 61-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-215 26152875-5 2015 The methanol extract of Angelica decursiva exhibited the highest inhibitory activities against alpha-glucosidase, PTP1B, AChE, and BChE and so was selected for further investigation. Methanol 4-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 26231935-8 2015 Although the three glycosylation sites within AChE sequence have different extent in affecting the enzymatic activity, their glycan compositions are very similar. Polysaccharides 125-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 26141104-3 2015 Herein, the sensing ensemble solution exhibits a marvelous fluorescent enhancement in the presence of AChE and ATCh, where AChE hydrolyzes its active substrate ATCh into thiocholine (TCh), and then TCh captures Cu(2+) from the ensemble, accompanied by the conversion from fluorescence off-state to on-state of the AuNCs. Thiocholine 112-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 26141104-3 2015 Herein, the sensing ensemble solution exhibits a marvelous fluorescent enhancement in the presence of AChE and ATCh, where AChE hydrolyzes its active substrate ATCh into thiocholine (TCh), and then TCh captures Cu(2+) from the ensemble, accompanied by the conversion from fluorescence off-state to on-state of the AuNCs. Thiocholine 161-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 26141104-3 2015 Herein, the sensing ensemble solution exhibits a marvelous fluorescent enhancement in the presence of AChE and ATCh, where AChE hydrolyzes its active substrate ATCh into thiocholine (TCh), and then TCh captures Cu(2+) from the ensemble, accompanied by the conversion from fluorescence off-state to on-state of the AuNCs. Thiocholine 161-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 26141104-3 2015 Herein, the sensing ensemble solution exhibits a marvelous fluorescent enhancement in the presence of AChE and ATCh, where AChE hydrolyzes its active substrate ATCh into thiocholine (TCh), and then TCh captures Cu(2+) from the ensemble, accompanied by the conversion from fluorescence off-state to on-state of the AuNCs. Copper 211-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 26141104-3 2015 Herein, the sensing ensemble solution exhibits a marvelous fluorescent enhancement in the presence of AChE and ATCh, where AChE hydrolyzes its active substrate ATCh into thiocholine (TCh), and then TCh captures Cu(2+) from the ensemble, accompanied by the conversion from fluorescence off-state to on-state of the AuNCs. Copper 211-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 26440714-3 2015 Coumarin linked thiourea derivatives were designed, synthesized and evaluated biologically in order to determine their inhibitory activity against acetylcholinesterases (AChE) and butyrylcholinesterases (BChE). coumarin 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 26440714-3 2015 Coumarin linked thiourea derivatives were designed, synthesized and evaluated biologically in order to determine their inhibitory activity against acetylcholinesterases (AChE) and butyrylcholinesterases (BChE). Thiourea 16-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 26440714-7 2015 Results showed that the novel synthesized coumarin linked thiourea derivatives are potential candidates to develop for potent and efficacious acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. coumarin 42-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 26440714-7 2015 Results showed that the novel synthesized coumarin linked thiourea derivatives are potential candidates to develop for potent and efficacious acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. coumarin 42-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 26440714-7 2015 Results showed that the novel synthesized coumarin linked thiourea derivatives are potential candidates to develop for potent and efficacious acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. Thiourea 58-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 26440714-7 2015 Results showed that the novel synthesized coumarin linked thiourea derivatives are potential candidates to develop for potent and efficacious acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors. Thiourea 58-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 25586344-5 2015 In the present study, the inhibition effect of the hydroquinone (benzene-1,4-diol) on AChE activity was evaluated and effectively inhibited AChE with Ki of 1.22 nM. hydroquinone 51-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 25586344-5 2015 In the present study, the inhibition effect of the hydroquinone (benzene-1,4-diol) on AChE activity was evaluated and effectively inhibited AChE with Ki of 1.22 nM. hydroquinone 51-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 25586344-5 2015 In the present study, the inhibition effect of the hydroquinone (benzene-1,4-diol) on AChE activity was evaluated and effectively inhibited AChE with Ki of 1.22 nM. hydroquinone 65-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 25586344-5 2015 In the present study, the inhibition effect of the hydroquinone (benzene-1,4-diol) on AChE activity was evaluated and effectively inhibited AChE with Ki of 1.22 nM. hydroquinone 65-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 26459445-2 2015 Paper-based platforms, including point-of-care devices and 96-well plates, provided semi-quantitative information regarding the concentration of AchE (a biomarker for organophosphate poisoning). Organophosphates 167-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 23625910-0 2015 Effect of paraoxonase 1 192 Q/R polymorphism on paraoxonase and acetylcholinesterase enzyme activities in a Turkish population exposed to organophosphate. Organophosphates 138-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 23625910-3 2015 The aim of this study was to determine the effects of PON1 gene polymorphism and its effects on PON and AChE enzyme activities in individuals who were exposed to organophosphorus insecticides due to occupational reasons, and to profile the probability of susceptibility to organophosphorus compounds. organophosphorus 162-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 26618560-1 2015 INTRODUCTION: Acetylcholinesterase inhibition by organophosphorus insecticides can cause acute parasympathetic system dysfunction, muscle weakness, seizures, coma, and respiratory failure. organophosphorus 49-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 26468911-0 2015 Protein-Drug Interactions with Effective Polarization in Polarizable Water: Oxime Unbinding from AChE Gorge. Water 69-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 26468911-0 2015 Protein-Drug Interactions with Effective Polarization in Polarizable Water: Oxime Unbinding from AChE Gorge. Oximes 76-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 26468911-2 2015 We present oxime (HI-6) unbinding from the active site gorge of AChE, known to be strongly influenced by intermolecular cation-pi, hydrogen bridge (HB) and water bridge (WB) interactions and by molecular simulations with effective polarization in polarizable mean-field model of TIP3P water. Oximes 11-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 26468911-2 2015 We present oxime (HI-6) unbinding from the active site gorge of AChE, known to be strongly influenced by intermolecular cation-pi, hydrogen bridge (HB) and water bridge (WB) interactions and by molecular simulations with effective polarization in polarizable mean-field model of TIP3P water. asoxime chloride 18-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 26468911-2 2015 We present oxime (HI-6) unbinding from the active site gorge of AChE, known to be strongly influenced by intermolecular cation-pi, hydrogen bridge (HB) and water bridge (WB) interactions and by molecular simulations with effective polarization in polarizable mean-field model of TIP3P water. Hydrogen 131-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 26468911-2 2015 We present oxime (HI-6) unbinding from the active site gorge of AChE, known to be strongly influenced by intermolecular cation-pi, hydrogen bridge (HB) and water bridge (WB) interactions and by molecular simulations with effective polarization in polarizable mean-field model of TIP3P water. Water 156-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 26468911-2 2015 We present oxime (HI-6) unbinding from the active site gorge of AChE, known to be strongly influenced by intermolecular cation-pi, hydrogen bridge (HB) and water bridge (WB) interactions and by molecular simulations with effective polarization in polarizable mean-field model of TIP3P water. Water 285-290 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 26617520-8 2015 Treatment with CoQ10 (20 and 40 mg/kg) and minocycline (50 and 100 mg/kg) alone for 21 days significantly improved cognitive performance as evidenced by reduced transfer latency and increased time spent in target quadrant (TSTQ), reduced AChE activity, oxidative damage (reduced LPO, nitrite level and restored SOD, catalase and GHS levels), TNF-alpha level, restored mitochondrial respiratory enzyme complex (I, II, III, IV) activities and histopathological alterations as compared to Abeta (1-42) treated animals. coenzyme Q10 15-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 238-242 26617520-8 2015 Treatment with CoQ10 (20 and 40 mg/kg) and minocycline (50 and 100 mg/kg) alone for 21 days significantly improved cognitive performance as evidenced by reduced transfer latency and increased time spent in target quadrant (TSTQ), reduced AChE activity, oxidative damage (reduced LPO, nitrite level and restored SOD, catalase and GHS levels), TNF-alpha level, restored mitochondrial respiratory enzyme complex (I, II, III, IV) activities and histopathological alterations as compared to Abeta (1-42) treated animals. Minocycline 43-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 238-242 26010139-1 2015 A series of 4-hydroxycoumarin-derived compounds 8a-p containing N-benzyl-1,2,3-triazole motif were designed as AChE inhibitors. 4-hydroxycoumarin 12-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 26010139-1 2015 A series of 4-hydroxycoumarin-derived compounds 8a-p containing N-benzyl-1,2,3-triazole motif were designed as AChE inhibitors. 8a-p 48-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 26010139-1 2015 A series of 4-hydroxycoumarin-derived compounds 8a-p containing N-benzyl-1,2,3-triazole motif were designed as AChE inhibitors. n-benzyl-1,2,3-triazole 64-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 26010139-4 2015 Among them, 2-chlorobenzyl derivative 8k showed the most potent activity against AChE (IC50 = 0.18 mum). 2-chlorobenzyl 12-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 26002584-5 2015 The AChE activity in non-cancerous tissues (0.248 +- 0.030 milliunits per milligram of wet tissue; mU/mg) demonstrates that upper respiratory tissues express sufficient AChE activity for controlling the level of acetylcholine (ACh). Acetylcholine 212-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 26002584-5 2015 The AChE activity in non-cancerous tissues (0.248 +- 0.030 milliunits per milligram of wet tissue; mU/mg) demonstrates that upper respiratory tissues express sufficient AChE activity for controlling the level of acetylcholine (ACh). Acetylcholine 212-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 26002584-5 2015 The AChE activity in non-cancerous tissues (0.248 +- 0.030 milliunits per milligram of wet tissue; mU/mg) demonstrates that upper respiratory tissues express sufficient AChE activity for controlling the level of acetylcholine (ACh). Acetylcholine 4-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 26003847-3 2015 Stressful intraperitoneal injection of saline, the anti-inflammatory TLR9 agonist mEN101 aptamer or the inflammation-activating TLR9 aptamer ODN 1826 all increased the expression of the acetylcholinesterase (AChE)-targeting miR-132. Sodium Chloride 39-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-206 26003847-3 2015 Stressful intraperitoneal injection of saline, the anti-inflammatory TLR9 agonist mEN101 aptamer or the inflammation-activating TLR9 aptamer ODN 1826 all increased the expression of the acetylcholinesterase (AChE)-targeting miR-132. Sodium Chloride 39-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-212 25792506-0 2015 Tacrine-propargylamine derivatives with improved acetylcholinesterase inhibitory activity and lower hepatotoxicity as a potential lead compound for the treatment of Alzheimer"s disease. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 25792506-0 2015 Tacrine-propargylamine derivatives with improved acetylcholinesterase inhibitory activity and lower hepatotoxicity as a potential lead compound for the treatment of Alzheimer"s disease. propargylamine 8-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 25807300-0 2015 (Thiazol-2-yl)hydrazone derivatives from acetylpyridines as dual inhibitors of MAO and AChE: synthesis, biological evaluation and molecular modeling studies. (thiazol-2-yl)hydrazone 0-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 25807300-0 2015 (Thiazol-2-yl)hydrazone derivatives from acetylpyridines as dual inhibitors of MAO and AChE: synthesis, biological evaluation and molecular modeling studies. acetylpyridines 41-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 26231935-0 2015 Three N-Glycosylation Sites of Human Acetylcholinesterase Shares Similar Glycan Composition. Nitrogen 6-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 26231935-0 2015 Three N-Glycosylation Sites of Human Acetylcholinesterase Shares Similar Glycan Composition. Polysaccharides 73-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 26231935-1 2015 Acetylcholinesterase (AChE; EC 3.1.1.7) is a glycoprotein possessing three conserved N-linked glycosylation sites in mammalian species, locating at 296, 381, and 495 residues of the human sequence. Nitrogen 85-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 26231935-1 2015 Acetylcholinesterase (AChE; EC 3.1.1.7) is a glycoprotein possessing three conserved N-linked glycosylation sites in mammalian species, locating at 296, 381, and 495 residues of the human sequence. Nitrogen 85-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 26231935-2 2015 Several lines of evidence demonstrated that N-glycosylation of AChE affected the enzymatic activity, as well as its biosynthesis. Nitrogen 44-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 26362598-0 2015 Solanocapsine derivatives as potential inhibitors of acetylcholinesterase: Synthesis, molecular docking and biological studies. Solanocapsine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 26362598-3 2015 This work describes the isolation of a natural compound, solanocapsine, the preparation of its chemical derivatives, the evaluation of AChE inhibitory activity, and the structure-activity analysis of relevant cases. Solanocapsine 57-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 26503905-2 2015 Several of them showed improved inhibitory properties toward acetylcholinesterase (AChE) in relation to tacrine. Tacrine 104-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 26503905-2 2015 Several of them showed improved inhibitory properties toward acetylcholinesterase (AChE) in relation to tacrine. Tacrine 104-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 26454504-3 2015 The 1-(4-fluorobenzyl) substituted derivative 9d exhibited the most potent anti-AChE activity with IC50 value of 8.9 nM and high AChE/BuChE selectivity (SI>230). 1-(4-fluorobenzyl 4-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 26454504-3 2015 The 1-(4-fluorobenzyl) substituted derivative 9d exhibited the most potent anti-AChE activity with IC50 value of 8.9 nM and high AChE/BuChE selectivity (SI>230). 1-(4-fluorobenzyl 4-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 26454504-4 2015 Kinetic and molecular modeling studies suggested that compound 9d was mixed-type inhibitor, binding simultaneously to CAS and PAS of AChE. Protactinium 126-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 26460283-7 2015 This library of lysine-conjugated dendrimers showed the ability to efficiently capture the pesticide dichlorvos, confirming the potential of dendrimer-based antidotes to maintain acetylcholinesterase activity in response to poisoning events. Lysine 16-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 179-199 26280153-0 2015 Dementia with Lewy bodies can be well-differentiated from Alzheimer"s disease by measurement of brain acetylcholinesterase activity-a [11C]MP4A PET study. Carbon-11 135-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 26280153-1 2015 OBJECTIVE: To investigate the diagnostic performance of brain acetylcholinesterase (AChE) activity measurement using N-[(11) C]-methyl-4-piperidyl acetate (MP4A) and PET in patients with dementia with Lewy bodies (DLB) and Alzheimer"s disease (AD). n-[(11) c]-methyl-4-piperidyl acetate 117-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 26280153-1 2015 OBJECTIVE: To investigate the diagnostic performance of brain acetylcholinesterase (AChE) activity measurement using N-[(11) C]-methyl-4-piperidyl acetate (MP4A) and PET in patients with dementia with Lewy bodies (DLB) and Alzheimer"s disease (AD). n-[(11) c]-methyl-4-piperidyl acetate 117-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 26280153-1 2015 OBJECTIVE: To investigate the diagnostic performance of brain acetylcholinesterase (AChE) activity measurement using N-[(11) C]-methyl-4-piperidyl acetate (MP4A) and PET in patients with dementia with Lewy bodies (DLB) and Alzheimer"s disease (AD). mp4a 156-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 26280153-1 2015 OBJECTIVE: To investigate the diagnostic performance of brain acetylcholinesterase (AChE) activity measurement using N-[(11) C]-methyl-4-piperidyl acetate (MP4A) and PET in patients with dementia with Lewy bodies (DLB) and Alzheimer"s disease (AD). mp4a 156-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 26280153-10 2015 All regional brain AChE activities of defined VOIs except ACG were able to well discriminate DLB from AD, and notably performance was the most significant in PCG (AUC = 0.989, 95% CI: 0.965-1.000). Penicillin G 158-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 25857716-0 2015 A selective molecularly imprinted polymer for immobilization of acetylcholinesterase (AChE): an active enzyme targeted and efficient method. Polymers 34-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 25857716-0 2015 A selective molecularly imprinted polymer for immobilization of acetylcholinesterase (AChE): an active enzyme targeted and efficient method. Polymers 34-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 25857716-1 2015 In the present study, we immobilized acetylcholinesterase (AChE) enzyme onto acetylcholine removed imprinted polymer and acetylcholine containing polymer. Acetylcholine 37-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 25857716-1 2015 In the present study, we immobilized acetylcholinesterase (AChE) enzyme onto acetylcholine removed imprinted polymer and acetylcholine containing polymer. Polymers 109-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 25857716-1 2015 In the present study, we immobilized acetylcholinesterase (AChE) enzyme onto acetylcholine removed imprinted polymer and acetylcholine containing polymer. Polymers 109-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 25857716-1 2015 In the present study, we immobilized acetylcholinesterase (AChE) enzyme onto acetylcholine removed imprinted polymer and acetylcholine containing polymer. Acetylcholine 77-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 25857716-1 2015 In the present study, we immobilized acetylcholinesterase (AChE) enzyme onto acetylcholine removed imprinted polymer and acetylcholine containing polymer. Acetylcholine 77-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 25857716-2 2015 First, the polymers were produced with acetylcholine, substrate of AChE, by dispersion polymerization. Acetylcholine 39-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 25857716-4 2015 In the second method (method B), AChE was immobilized onto acetylcholine containing polymer by affinity. Acetylcholine 59-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 25857716-6 2015 The immobilized AChE reached 240% relative specific activity comparison with free AChE because the active enzyme molecules bounded onto the polymer. Polymers 140-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 25857716-6 2015 The immobilized AChE reached 240% relative specific activity comparison with free AChE because the active enzyme molecules bounded onto the polymer. Polymers 140-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 26165232-1 2015 Acetylcholinesterase (AChE) is an enzyme responsible for metabolism of the neurotransmitter acetylcholine, and inhibition of AChE can have therapeutic applications (e.g., drugs for Alzheimer"s disease) or neurotoxic consequences (e.g., pesticides). Acetylcholine 92-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 26165232-1 2015 Acetylcholinesterase (AChE) is an enzyme responsible for metabolism of the neurotransmitter acetylcholine, and inhibition of AChE can have therapeutic applications (e.g., drugs for Alzheimer"s disease) or neurotoxic consequences (e.g., pesticides). Acetylcholine 92-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 26165232-1 2015 Acetylcholinesterase (AChE) is an enzyme responsible for metabolism of the neurotransmitter acetylcholine, and inhibition of AChE can have therapeutic applications (e.g., drugs for Alzheimer"s disease) or neurotoxic consequences (e.g., pesticides). Acetylcholine 92-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 26165232-2 2015 A common absorbance-based AChE activity assay that uses 5,5"-dithiobis(2-nitrobenzoic acid) (DTNB) can have limited sensitivity and be prone to interference. Dithionitrobenzoic Acid 56-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 26165232-2 2015 A common absorbance-based AChE activity assay that uses 5,5"-dithiobis(2-nitrobenzoic acid) (DTNB) can have limited sensitivity and be prone to interference. Dithionitrobenzoic Acid 93-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 26165232-3 2015 Therefore, an alternative assay was developed, in which AChE activity was determined by measuring fluorescence of resorufin produced from coupled enzyme reactions involving acetylcholine and Amplex Red (10-acetyl-3,7-dihydroxyphenoxazine). resorufin 114-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 26165232-3 2015 Therefore, an alternative assay was developed, in which AChE activity was determined by measuring fluorescence of resorufin produced from coupled enzyme reactions involving acetylcholine and Amplex Red (10-acetyl-3,7-dihydroxyphenoxazine). Acetylcholine 173-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 26165232-3 2015 Therefore, an alternative assay was developed, in which AChE activity was determined by measuring fluorescence of resorufin produced from coupled enzyme reactions involving acetylcholine and Amplex Red (10-acetyl-3,7-dihydroxyphenoxazine). Amplex Red 191-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 26165232-3 2015 Therefore, an alternative assay was developed, in which AChE activity was determined by measuring fluorescence of resorufin produced from coupled enzyme reactions involving acetylcholine and Amplex Red (10-acetyl-3,7-dihydroxyphenoxazine). Amplex Red 203-237 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 26165232-9 2015 Lastly, in addition to inhibition, AChE reactivation was measured in SH-SY5Y cells incubated with pralidoxime chloride (2-PAM). pralidoxime 98-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 26941804-8 2015 Also, MgO NPs (100 mug/mL) meaningfully restored CP-induced increase of TNF-alpha (P < 0.001) and decrease of AChE activity (P < 0.001) and were capable of preventing CP-treated human lymphocytes from apoptosis (P < 0.001). Magnesium Oxide 6-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 25620714-0 2015 Inhibition effect of graphene oxide on the catalytic activity of acetylcholinesterase enzyme. graphene oxide 21-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 25620714-1 2015 Variations in the enzyme activity of acetylcholinesterase (AChE) in the presence of the nano-material, graphene oxide (GO), were investigated with the use of molecular spectroscopy UV-visible and fluorescence methods. graphene oxide 103-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 25620714-1 2015 Variations in the enzyme activity of acetylcholinesterase (AChE) in the presence of the nano-material, graphene oxide (GO), were investigated with the use of molecular spectroscopy UV-visible and fluorescence methods. graphene oxide 103-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 25620714-1 2015 Variations in the enzyme activity of acetylcholinesterase (AChE) in the presence of the nano-material, graphene oxide (GO), were investigated with the use of molecular spectroscopy UV-visible and fluorescence methods. graphene oxide 119-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 25620714-1 2015 Variations in the enzyme activity of acetylcholinesterase (AChE) in the presence of the nano-material, graphene oxide (GO), were investigated with the use of molecular spectroscopy UV-visible and fluorescence methods. graphene oxide 119-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 25620714-5 2015 Furthermore, it was found that the resonance light-scattering (RLS) intensity of AChE changed in the presence of GO. graphene oxide 113-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 25894361-7 2015 Based on the docking studies, scaffold 2-thiazolylimino-5-benzylidene-thiazolidin-4-one is observed to exhibit affinity against diverse targets, particularly, towards COX-2, acetylcholinesterase, aldose reductase, and thyroid hormone receptor alpha. 2-thiazolylimino-5-benzylidene-thiazolidin-4-one 39-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-194 26749833-0 2015 Bromotyrosine Alkaloids with Acetylcholinesterase Inhibitory Activity from the Thai Sponge Acanthodendrilla sp. bromotyrosine alkaloids 0-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 26749833-5 2015 Only homoaerothionin (7) and fistularin 1 (10) exhibited inhibitory activity against human recombinant AChE (hrAChE) with IC50s of 4.5 and 47.5 microM, respectively. homoaerothionin 5-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 26452809-2 2015 Paper-based platforms, including point-of-care devices and 96-well plates, provided semi-quantitative information regarding the concentration of AchE (a biomarker for organophosphate poisoning). Organophosphates 167-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 26520174-3 2015 The non-target toxicity and resistance problem of organophosphate and carbamate have become of growing concern, which may be due to the fact that they target the ubiquitous catalytic serine residue of acetylcholinesterase (AChE) in mammals, birds, and beneficial insects. Organophosphates 50-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 223-227 26520174-3 2015 The non-target toxicity and resistance problem of organophosphate and carbamate have become of growing concern, which may be due to the fact that they target the ubiquitous catalytic serine residue of acetylcholinesterase (AChE) in mammals, birds, and beneficial insects. Carbamates 70-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 223-227 26520174-3 2015 The non-target toxicity and resistance problem of organophosphate and carbamate have become of growing concern, which may be due to the fact that they target the ubiquitous catalytic serine residue of acetylcholinesterase (AChE) in mammals, birds, and beneficial insects. Serine 183-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 223-227 26202430-1 2015 Acetylcholinesterase (AChE), a serine hydrolase vital for regulating the neurotransmitter acetylcholine in animals, has been used as a target for drugs and pesticides. Acetylcholine 90-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 26202430-1 2015 Acetylcholinesterase (AChE), a serine hydrolase vital for regulating the neurotransmitter acetylcholine in animals, has been used as a target for drugs and pesticides. Acetylcholine 90-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 25828536-2 2015 Similar to acetylcholinesterase, the enzyme reacts with organophosphorus compounds (OP) like nerve agents or pesticides that cause enzyme inhibition (BChE adducts). Organophosphorus Compounds 56-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 26314619-4 2015 We studied two different pesticides, chlorpyrifos and carbaryl, which specifically inhibit acetylcholinesterase (AChE) in the nervous system. Chlorpyrifos 37-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 26314619-4 2015 We studied two different pesticides, chlorpyrifos and carbaryl, which specifically inhibit acetylcholinesterase (AChE) in the nervous system. Chlorpyrifos 37-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 26314619-4 2015 We studied two different pesticides, chlorpyrifos and carbaryl, which specifically inhibit acetylcholinesterase (AChE) in the nervous system. Carbaryl 54-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 26314619-4 2015 We studied two different pesticides, chlorpyrifos and carbaryl, which specifically inhibit acetylcholinesterase (AChE) in the nervous system. Carbaryl 54-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 26363872-1 2015 A series of benzofuran-based chalconoids 6a-v were designed and synthesized as new potential AChE inhibitors. benzofuran-based chalconoids 12-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 26350723-0 2015 Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates. Organophosphates 88-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 26350723-1 2015 Acetylcholinesterase (AChE) that has been covalently inhibited by organophosphate compounds (OPCs), such as nerve agents and pesticides, has traditionally been reactivated by using nucleophilic oximes. organophosphate compounds 66-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 26350723-1 2015 Acetylcholinesterase (AChE) that has been covalently inhibited by organophosphate compounds (OPCs), such as nerve agents and pesticides, has traditionally been reactivated by using nucleophilic oximes. organophosphate compounds 66-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 26350723-1 2015 Acetylcholinesterase (AChE) that has been covalently inhibited by organophosphate compounds (OPCs), such as nerve agents and pesticides, has traditionally been reactivated by using nucleophilic oximes. opcs 93-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 26350723-1 2015 Acetylcholinesterase (AChE) that has been covalently inhibited by organophosphate compounds (OPCs), such as nerve agents and pesticides, has traditionally been reactivated by using nucleophilic oximes. opcs 93-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 26350723-3 2015 Here we describe our discovery of new functional groups--Mannich phenols and general bases--that are capable of reactivating OPC--inhibited AChE more efficiently than standard oximes and we describe the cooperative mechanism by which these functionalities are delivered to the active site. mannich 57-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 26350723-3 2015 Here we describe our discovery of new functional groups--Mannich phenols and general bases--that are capable of reactivating OPC--inhibited AChE more efficiently than standard oximes and we describe the cooperative mechanism by which these functionalities are delivered to the active site. Phenols 65-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 26210949-0 2015 Acute and long-term exposure to chlorpyrifos induces cell death of basal forebrain cholinergic neurons through AChE variants alteration. Chlorpyrifos 32-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 25736722-1 2015 A new series of icariin derivatives were synthesized and evaluated for their in vitro acetylcholinesterase (AChE) inhibitory activity. icariin 16-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 25736722-1 2015 A new series of icariin derivatives were synthesized and evaluated for their in vitro acetylcholinesterase (AChE) inhibitory activity. icariin 16-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 26583300-4 2015 These drugs, by reversibly blocking the hydrolytic activity of AChE, increase the availability of synaptic acetylcholine. Acetylcholine 107-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 25900047-3 2015 The abietane diterpenoids (12-O-demethylcryptojaponol and 6alpha-hydroxydemethylcryptojaponol) showed potent inhibitory activity against acetylcholinesterase from human erythrocytes and electric eel, and against butyrylcholinesterase from horse serum. Abietanes 4-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 26186137-5 2015 This study investigated the changes in maternal acetylcholinesterase (AChE) and paraoxonase 1 (PON1) activities and their relation to urinary diakylphosphates (DAPs), class-related metabolites of OP pesticides, during pregnancy. diakylphosphates 142-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 26159481-0 2015 A computational view on the significance of E-ring in binding of (+)-arisugacin A to acetylcholinesterase. arisugacin A 65-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 26159481-1 2015 A computational docking study of a series of de novo structural analogs of the highly potent, non-nitrogen containing, acetylcholinesterase inhibitor (+)-arisugacin A is presented. Nitrogen 98-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 26159481-1 2015 A computational docking study of a series of de novo structural analogs of the highly potent, non-nitrogen containing, acetylcholinesterase inhibitor (+)-arisugacin A is presented. arisugacin A 150-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 26159481-2 2015 In direct comparison to the recently reported X-ray single-crystal structure of (+)-territrem B bound hAChE, the modeling suggests that there is a unique conformational preference for the E-ring that is responsible for the superior inhibitory activity of (+)-arisugacin A against hAChE relative to (+)-territrem B, and that substitutions on the E-ring also play an important role in the protein-ligand interaction. arisugacin A 255-271 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-107 26159481-2 2015 In direct comparison to the recently reported X-ray single-crystal structure of (+)-territrem B bound hAChE, the modeling suggests that there is a unique conformational preference for the E-ring that is responsible for the superior inhibitory activity of (+)-arisugacin A against hAChE relative to (+)-territrem B, and that substitutions on the E-ring also play an important role in the protein-ligand interaction. arisugacin A 255-271 acetylcholinesterase (Cartwright blood group) Homo sapiens 280-285 26078409-1 2015 The current standard of care for treatment of organophosphate (OP) poisoning includes pretreatment with the weak reversible acetylcholinesterase (AChE) inhibitor pyridostigmine bromide. Organophosphates 46-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 26078409-1 2015 The current standard of care for treatment of organophosphate (OP) poisoning includes pretreatment with the weak reversible acetylcholinesterase (AChE) inhibitor pyridostigmine bromide. Organophosphates 46-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 26078409-1 2015 The current standard of care for treatment of organophosphate (OP) poisoning includes pretreatment with the weak reversible acetylcholinesterase (AChE) inhibitor pyridostigmine bromide. Pyridostigmine Bromide 162-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 26078409-1 2015 The current standard of care for treatment of organophosphate (OP) poisoning includes pretreatment with the weak reversible acetylcholinesterase (AChE) inhibitor pyridostigmine bromide. Pyridostigmine Bromide 162-184 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 25900047-3 2015 The abietane diterpenoids (12-O-demethylcryptojaponol and 6alpha-hydroxydemethylcryptojaponol) showed potent inhibitory activity against acetylcholinesterase from human erythrocytes and electric eel, and against butyrylcholinesterase from horse serum. Diterpenes 13-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 25900047-3 2015 The abietane diterpenoids (12-O-demethylcryptojaponol and 6alpha-hydroxydemethylcryptojaponol) showed potent inhibitory activity against acetylcholinesterase from human erythrocytes and electric eel, and against butyrylcholinesterase from horse serum. 11-Hydroxy-sugiol 27-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 25900047-3 2015 The abietane diterpenoids (12-O-demethylcryptojaponol and 6alpha-hydroxydemethylcryptojaponol) showed potent inhibitory activity against acetylcholinesterase from human erythrocytes and electric eel, and against butyrylcholinesterase from horse serum. CHEMBL2252749 58-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 23572393-1 2015 The current study was aimed to scrutinize acetylcholinesterase (AchE) inhibitory profile of two antidepressants, diazepam and phenobarbitone. Diazepam 113-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 25758980-1 2015 Acetylcholinesterase (AChE) inhibition has been described as the main mechanism of organophosphate (OP)-evoked toxicity. Organophosphates 83-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 25758980-1 2015 Acetylcholinesterase (AChE) inhibition has been described as the main mechanism of organophosphate (OP)-evoked toxicity. Organophosphates 83-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 23572393-1 2015 The current study was aimed to scrutinize acetylcholinesterase (AchE) inhibitory profile of two antidepressants, diazepam and phenobarbitone. Diazepam 113-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 23572393-1 2015 The current study was aimed to scrutinize acetylcholinesterase (AchE) inhibitory profile of two antidepressants, diazepam and phenobarbitone. Phenobarbital 126-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 23572393-1 2015 The current study was aimed to scrutinize acetylcholinesterase (AchE) inhibitory profile of two antidepressants, diazepam and phenobarbitone. Phenobarbital 126-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 23572393-3 2015 The results showed marked inhibition of AchE by diazepam and the values of aKm and aVm were 65.5% and 52.63%, respectively. Diazepam 48-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 23572393-5 2015 Similar trend of antagonism was shown by phenobarbitone when it was subjected to the challenge of AchE with aKm and aVm values of 51.99% and 71.80%, respectively. Phenobarbital 41-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 23572393-6 2015 It is concluded that diazepam and phenobarbitone exhibited prominent AchE attenuation apart from their well-established antidepressant activity, which could be more useful in related diseased conditions. Diazepam 21-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 23572393-6 2015 It is concluded that diazepam and phenobarbitone exhibited prominent AchE attenuation apart from their well-established antidepressant activity, which could be more useful in related diseased conditions. Phenobarbital 34-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 26248214-3 2015 This work presents the design, synthesis, and biochemical evaluation of a series of chalcones, and assesses the relationship between their structures and their ability to bind metal ions and/or Abeta species, and inhibit AChE/BChE activity. Chalcones 84-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 221-225 26248214-4 2015 Several chalcones were found to exhibit potent disaggregation of pre-formed N-biotinyl Abeta1-42 (bioAbeta42) aggregates in vitro in the absence and presence of Cu(2+)/Zn(2+), while others were effective at inhibiting the action of AChE. Chalcones 8-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 232-236 26244990-1 2015 New benzofuranylthiazole derivatives containing the aryl-urea moiety were synthesized and evaluated in vitro as dual acetylcholinesterase (AChE)-butyrylcholinesterase (BuChE) inhibitors. benzofuranylthiazole 4-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 26664715-5 2015 In this case series report, we present the effect of rivastigmine, an acetylcholinesterase inhibitor, on cognitive impairment in three older, severely depressed patients during or after a course of ECT. Rivastigmine 53-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 26364275-0 2015 Safety and Preliminary Efficacy of the Acetylcholinesterase Inhibitor Huperzine A as a Treatment for Cocaine Use Disorder. huperzine A 70-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 26364275-2 2015 In particular, acetylcholinesterase inhibitors, like huperzine A, may be effective as treatments for cocaine use disorder. huperzine A 53-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 26200465-1 2015 BACKGROUND: Physostigmine, a centrally acting acetylcholinesterase inhibitor, is most commonly used by anesthesiologists in the postanesthetic setting to reverse confusion caused by central anticholinergic medication effects. Physostigmine 12-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 26192069-0 2015 Synthesis and Evaluation of Chroman-4-One Linked to N-Benzyl Pyridinium Derivatives as New Acetylcholinesterase Inhibitors. 4-Chromanone 28-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 26192069-0 2015 Synthesis and Evaluation of Chroman-4-One Linked to N-Benzyl Pyridinium Derivatives as New Acetylcholinesterase Inhibitors. n-benzyl pyridinium 52-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 26192069-1 2015 A novel series of chroman-4-one derivatives containing the N-benzyl pyridinium moiety were designed, synthesized, and evaluated for their acetylcholinesterase (AChE) inhibitory activities. 4-Chromanone 18-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 26192069-1 2015 A novel series of chroman-4-one derivatives containing the N-benzyl pyridinium moiety were designed, synthesized, and evaluated for their acetylcholinesterase (AChE) inhibitory activities. 4-Chromanone 18-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 26192069-1 2015 A novel series of chroman-4-one derivatives containing the N-benzyl pyridinium moiety were designed, synthesized, and evaluated for their acetylcholinesterase (AChE) inhibitory activities. n-benzyl pyridinium 59-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 26192069-2 2015 Among the various synthesized compounds, (E)-1-(2,3-dibromobenzyl)-4-((7-ethoxy-4-oxochroman-3-ylidene)methyl)pyridinium bromide (8l) depicted the most potent anti-AChE activity (IC50 = 0.048 muM). (e)-1-(2,3-dibromobenzyl)-4-((7-ethoxy-4-oxochroman-3-ylidene)methyl)pyridinium bromide 41-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 26189031-1 2015 A novel serie of escitalopram triazoles (60-88) and a tetrazole (89) have been synthesized and subjected to a study to establish the inhibitory potential of these compounds toward acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). escitalopram triazoles 17-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-200 26189031-1 2015 A novel serie of escitalopram triazoles (60-88) and a tetrazole (89) have been synthesized and subjected to a study to establish the inhibitory potential of these compounds toward acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). 1H-tetrazole 54-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 202-206 26260334-0 2015 Galantamine derivatives with indole moiety: Docking, design, synthesis and acetylcholinesterase inhibitory activity. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 26260334-0 2015 Galantamine derivatives with indole moiety: Docking, design, synthesis and acetylcholinesterase inhibitory activity. indole 29-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 26260334-3 2015 In the present study, 41 galantamine derivatives with known acetylcholinesterase inhibitory activities expressed as IC50 were selected from the literature and docked into a recombinant human acetylcholinesterase by GOLD. Galantamine 25-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 26260334-3 2015 In the present study, 41 galantamine derivatives with known acetylcholinesterase inhibitory activities expressed as IC50 were selected from the literature and docked into a recombinant human acetylcholinesterase by GOLD. Galantamine 25-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 191-211 26260334-8 2015 Additionally, the indole moiety of one of the novel inhibitors binds in a region, close to the peripheral anionic site of the enzyme, where the Omega-loop of amyloid beta peptide adheres to acetylcholinesterase. indole 18-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 190-210 26244990-1 2015 New benzofuranylthiazole derivatives containing the aryl-urea moiety were synthesized and evaluated in vitro as dual acetylcholinesterase (AChE)-butyrylcholinesterase (BuChE) inhibitors. benzofuranylthiazole 4-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 26244990-3 2015 The result showed that all the synthesized compounds exhibited inhibitory activity on both AChE and BuChE with 1-(4-(5-bromobenzofuran-2-yl)thiazol-2-yl)-3-(2-fluorophenyl)urea (e25, IC50 value of 3.85 muM) and 1-(4-iodophenyl)-3-(4-(5-nitrobenzofuran-2-yl)thiazol-2-yl)urea (e38, IC50 value of 2.03 muM) as the strongest inhibitors against AChE and BuChE, respectively. Urea 172-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 26244990-3 2015 The result showed that all the synthesized compounds exhibited inhibitory activity on both AChE and BuChE with 1-(4-(5-bromobenzofuran-2-yl)thiazol-2-yl)-3-(2-fluorophenyl)urea (e25, IC50 value of 3.85 muM) and 1-(4-iodophenyl)-3-(4-(5-nitrobenzofuran-2-yl)thiazol-2-yl)urea (e38, IC50 value of 2.03 muM) as the strongest inhibitors against AChE and BuChE, respectively. Urea 270-274 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 26244990-7 2015 Best poses of compounds e38 on BuChE and e25 on AChE indicate that the thiazole ring and the amidic moiety are important sites of interaction with both ChEs. Thiazoles 71-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 26200472-6 2015 Replacement of hAChE residues known to be essential for its interaction with Fas with alanine, in this peptide, resulted in almost complete loss of binding to Fas. Alanine 86-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-20 25920465-1 2015 Exposure to organophosphorous (OP) nerve agents such as soman inhibits the critical enzyme acetylcholinesterase (AChE) leading to excessive acetylcholine accumulation in synapses, resulting in cholinergic crisis, status epilepticus and brain damage in survivors. organophosphorous 12-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 25920465-1 2015 Exposure to organophosphorous (OP) nerve agents such as soman inhibits the critical enzyme acetylcholinesterase (AChE) leading to excessive acetylcholine accumulation in synapses, resulting in cholinergic crisis, status epilepticus and brain damage in survivors. organophosphorous 12-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 25920465-1 2015 Exposure to organophosphorous (OP) nerve agents such as soman inhibits the critical enzyme acetylcholinesterase (AChE) leading to excessive acetylcholine accumulation in synapses, resulting in cholinergic crisis, status epilepticus and brain damage in survivors. Acetylcholine 91-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 26325402-4 2015 One aspect of AD therapy is to maintain ACh level up to a safe limit, by blocking acetylcholinesterase (AChE), an enzyme that is naturally responsible for its degradation. Acetylcholine 40-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 26325402-4 2015 One aspect of AD therapy is to maintain ACh level up to a safe limit, by blocking acetylcholinesterase (AChE), an enzyme that is naturally responsible for its degradation. Acetylcholine 40-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 26072115-5 2015 Molecular docking of serotonin and AAA substrates (o-nitroacetanilide, and o-nitrotrifluoroacetanilide,) onto AChE shows that these compounds bind at the side door of AChE. Serotonin 21-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 26072115-5 2015 Molecular docking of serotonin and AAA substrates (o-nitroacetanilide, and o-nitrotrifluoroacetanilide,) onto AChE shows that these compounds bind at the side door of AChE. Serotonin 21-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 26072115-5 2015 Molecular docking of serotonin and AAA substrates (o-nitroacetanilide, and o-nitrotrifluoroacetanilide,) onto AChE shows that these compounds bind at the side door of AChE. 2-nitroacetanilide 51-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 26072115-5 2015 Molecular docking of serotonin and AAA substrates (o-nitroacetanilide, and o-nitrotrifluoroacetanilide,) onto AChE shows that these compounds bind at the side door of AChE. 2-nitroacetanilide 51-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 26072115-5 2015 Molecular docking of serotonin and AAA substrates (o-nitroacetanilide, and o-nitrotrifluoroacetanilide,) onto AChE shows that these compounds bind at the side door of AChE. 2-nitrotrifluoroacetanilide 75-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 26072115-5 2015 Molecular docking of serotonin and AAA substrates (o-nitroacetanilide, and o-nitrotrifluoroacetanilide,) onto AChE shows that these compounds bind at the side door of AChE. 2-nitrotrifluoroacetanilide 75-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 26072115-10 2015 Therefore, binding of PAS inhibitors at the main door of AChE remain ineffective against AAA activity. Protactinium 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 26438408-0 2015 Combined 3D-QSAR, molecular docking, and molecular dynamics study of tacrine derivatives as potential acetylcholinesterase (AChE) inhibitors of Alzheimer"s disease. Tacrine 69-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 26438408-0 2015 Combined 3D-QSAR, molecular docking, and molecular dynamics study of tacrine derivatives as potential acetylcholinesterase (AChE) inhibitors of Alzheimer"s disease. Tacrine 69-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 26438408-2 2015 Tacrine is an approved drug with AChE-inhibitory activity. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 26438408-3 2015 In this paper, 3D-QSAR, molecular docking, and molecular dynamics were carried out in order to study 60 tacrine derivatives and their AChE-inhibitory activities. Tacrine 104-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 25407587-0 2015 Molecular modeling and in vitro reactivation study between the oxime BI-6 and acetylcholinesterase inhibited by different nerve agents. Oximes 63-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-98 25407587-1 2015 Nerve agents are organophosphates acting as potent inhibitors of acetylcholinesterase (AChE), the enzyme responsible for the hydrolysis of acetylcholine and, consequently, the termination of the transmission of nerve impulses. Organophosphates 17-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 25407587-1 2015 Nerve agents are organophosphates acting as potent inhibitors of acetylcholinesterase (AChE), the enzyme responsible for the hydrolysis of acetylcholine and, consequently, the termination of the transmission of nerve impulses. Organophosphates 17-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 25407587-1 2015 Nerve agents are organophosphates acting as potent inhibitors of acetylcholinesterase (AChE), the enzyme responsible for the hydrolysis of acetylcholine and, consequently, the termination of the transmission of nerve impulses. Acetylcholine 65-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 25407587-2 2015 The inhibition of AChE by an organophosphate can be reversed by a nucleophilic agent able to dephosphorylate a serine residue in the active site of AChE. Organophosphates 29-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 25407587-2 2015 The inhibition of AChE by an organophosphate can be reversed by a nucleophilic agent able to dephosphorylate a serine residue in the active site of AChE. Organophosphates 29-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 25407587-2 2015 The inhibition of AChE by an organophosphate can be reversed by a nucleophilic agent able to dephosphorylate a serine residue in the active site of AChE. Serine 111-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 25407587-2 2015 The inhibition of AChE by an organophosphate can be reversed by a nucleophilic agent able to dephosphorylate a serine residue in the active site of AChE. Serine 111-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 25407587-4 2015 Here, we have applied a methodology involving theoretical docking and Quantum Mechanics/Molecular Mechanics, using the softwares Molegro( ) and Spartan( ), to evaluate the kinetic constants of reactivation and the interactions of the oxime BI-6 with AChE inhibited by different organophosphorus compounds in comparison to in vitro data. oxime bi-6 234-244 acetylcholinesterase (Cartwright blood group) Homo sapiens 250-254 25407587-4 2015 Here, we have applied a methodology involving theoretical docking and Quantum Mechanics/Molecular Mechanics, using the softwares Molegro( ) and Spartan( ), to evaluate the kinetic constants of reactivation and the interactions of the oxime BI-6 with AChE inhibited by different organophosphorus compounds in comparison to in vitro data. organophosphorus 278-294 acetylcholinesterase (Cartwright blood group) Homo sapiens 250-254 26420918-9 2015 From, our extensive analysis involving binding affinity analysis, ADMET properties predictions and pharmacophoric mappings, we report p-cholorophenyl substituted rivastigmine and fluoxetine hybrid (26d) to be a potential candidate for AcHE inhibition which in addition can overcome narrow therapeutic window of present AChE inhibitors in clinical treatment of Alzheimer s disease. p-cholorophenyl substituted rivastigmine 134-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 235-239 26420918-9 2015 From, our extensive analysis involving binding affinity analysis, ADMET properties predictions and pharmacophoric mappings, we report p-cholorophenyl substituted rivastigmine and fluoxetine hybrid (26d) to be a potential candidate for AcHE inhibition which in addition can overcome narrow therapeutic window of present AChE inhibitors in clinical treatment of Alzheimer s disease. p-cholorophenyl substituted rivastigmine 134-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 319-323 26420918-9 2015 From, our extensive analysis involving binding affinity analysis, ADMET properties predictions and pharmacophoric mappings, we report p-cholorophenyl substituted rivastigmine and fluoxetine hybrid (26d) to be a potential candidate for AcHE inhibition which in addition can overcome narrow therapeutic window of present AChE inhibitors in clinical treatment of Alzheimer s disease. Fluoxetine 179-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 235-239 26420918-9 2015 From, our extensive analysis involving binding affinity analysis, ADMET properties predictions and pharmacophoric mappings, we report p-cholorophenyl substituted rivastigmine and fluoxetine hybrid (26d) to be a potential candidate for AcHE inhibition which in addition can overcome narrow therapeutic window of present AChE inhibitors in clinical treatment of Alzheimer s disease. Fluoxetine 179-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 319-323 26087169-2 2015 The detection principle is based on the irreversible inhibition of the enzymatic activity of acetylcholinesterase (AchE) by methyl parathion; AchE catalytically hydrolyzes acetylthiocholine iodine to thiocholine that in turn dissociates dithiobis-nitrobenzoate to produce a yellow product (deprotonated thio-nitrobenzoate). Methyl Parathion 124-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 26087169-2 2015 The detection principle is based on the irreversible inhibition of the enzymatic activity of acetylcholinesterase (AchE) by methyl parathion; AchE catalytically hydrolyzes acetylthiocholine iodine to thiocholine that in turn dissociates dithiobis-nitrobenzoate to produce a yellow product (deprotonated thio-nitrobenzoate). Methyl Parathion 124-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 26087169-2 2015 The detection principle is based on the irreversible inhibition of the enzymatic activity of acetylcholinesterase (AchE) by methyl parathion; AchE catalytically hydrolyzes acetylthiocholine iodine to thiocholine that in turn dissociates dithiobis-nitrobenzoate to produce a yellow product (deprotonated thio-nitrobenzoate). Methyl Parathion 124-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 26087169-2 2015 The detection principle is based on the irreversible inhibition of the enzymatic activity of acetylcholinesterase (AchE) by methyl parathion; AchE catalytically hydrolyzes acetylthiocholine iodine to thiocholine that in turn dissociates dithiobis-nitrobenzoate to produce a yellow product (deprotonated thio-nitrobenzoate). acetylthiocholine iodine 172-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 26087169-2 2015 The detection principle is based on the irreversible inhibition of the enzymatic activity of acetylcholinesterase (AchE) by methyl parathion; AchE catalytically hydrolyzes acetylthiocholine iodine to thiocholine that in turn dissociates dithiobis-nitrobenzoate to produce a yellow product (deprotonated thio-nitrobenzoate). acetylthiocholine iodine 172-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 26087169-2 2015 The detection principle is based on the irreversible inhibition of the enzymatic activity of acetylcholinesterase (AchE) by methyl parathion; AchE catalytically hydrolyzes acetylthiocholine iodine to thiocholine that in turn dissociates dithiobis-nitrobenzoate to produce a yellow product (deprotonated thio-nitrobenzoate). acetylthiocholine iodine 172-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 26087169-2 2015 The detection principle is based on the irreversible inhibition of the enzymatic activity of acetylcholinesterase (AchE) by methyl parathion; AchE catalytically hydrolyzes acetylthiocholine iodine to thiocholine that in turn dissociates dithiobis-nitrobenzoate to produce a yellow product (deprotonated thio-nitrobenzoate). Thiocholine 178-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 26087169-2 2015 The detection principle is based on the irreversible inhibition of the enzymatic activity of acetylcholinesterase (AchE) by methyl parathion; AchE catalytically hydrolyzes acetylthiocholine iodine to thiocholine that in turn dissociates dithiobis-nitrobenzoate to produce a yellow product (deprotonated thio-nitrobenzoate). Thiocholine 178-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 26087169-2 2015 The detection principle is based on the irreversible inhibition of the enzymatic activity of acetylcholinesterase (AchE) by methyl parathion; AchE catalytically hydrolyzes acetylthiocholine iodine to thiocholine that in turn dissociates dithiobis-nitrobenzoate to produce a yellow product (deprotonated thio-nitrobenzoate). Thiocholine 178-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 26087169-2 2015 The detection principle is based on the irreversible inhibition of the enzymatic activity of acetylcholinesterase (AchE) by methyl parathion; AchE catalytically hydrolyzes acetylthiocholine iodine to thiocholine that in turn dissociates dithiobis-nitrobenzoate to produce a yellow product (deprotonated thio-nitrobenzoate). dithiobis-nitrobenzoate 237-260 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 26087169-2 2015 The detection principle is based on the irreversible inhibition of the enzymatic activity of acetylcholinesterase (AchE) by methyl parathion; AchE catalytically hydrolyzes acetylthiocholine iodine to thiocholine that in turn dissociates dithiobis-nitrobenzoate to produce a yellow product (deprotonated thio-nitrobenzoate). dithiobis-nitrobenzoate 237-260 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 26087169-2 2015 The detection principle is based on the irreversible inhibition of the enzymatic activity of acetylcholinesterase (AchE) by methyl parathion; AchE catalytically hydrolyzes acetylthiocholine iodine to thiocholine that in turn dissociates dithiobis-nitrobenzoate to produce a yellow product (deprotonated thio-nitrobenzoate). dithiobis-nitrobenzoate 237-260 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 26087169-2 2015 The detection principle is based on the irreversible inhibition of the enzymatic activity of acetylcholinesterase (AchE) by methyl parathion; AchE catalytically hydrolyzes acetylthiocholine iodine to thiocholine that in turn dissociates dithiobis-nitrobenzoate to produce a yellow product (deprotonated thio-nitrobenzoate). thionitrobenzoic acid 303-321 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 26087169-2 2015 The detection principle is based on the irreversible inhibition of the enzymatic activity of acetylcholinesterase (AchE) by methyl parathion; AchE catalytically hydrolyzes acetylthiocholine iodine to thiocholine that in turn dissociates dithiobis-nitrobenzoate to produce a yellow product (deprotonated thio-nitrobenzoate). thionitrobenzoic acid 303-321 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 26087169-2 2015 The detection principle is based on the irreversible inhibition of the enzymatic activity of acetylcholinesterase (AchE) by methyl parathion; AchE catalytically hydrolyzes acetylthiocholine iodine to thiocholine that in turn dissociates dithiobis-nitrobenzoate to produce a yellow product (deprotonated thio-nitrobenzoate). thionitrobenzoic acid 303-321 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 26243006-5 2015 Regular monitoring of erythrocyte AChE will enable farmers to identify potential exposure to organophosphate insecticides and take action to reduce exposures and improve their health and safety practices. Organophosphates 93-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 26032855-3 2015 We designed the target compounds as dual binding site acetylcholinesterase inhibitors, where the N-benzylamine pharmacophore is responsible for interactions with the catalytic anionic site of the enzyme. benzylamine 97-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 26032855-5 2015 Based on the results of the pharmacological evaluation, we identified compound 8b with a saccharine moiety as the most potent and selective human acetylcholinesterase inhibitor (IC50 = 33 nM) and beta amyloid aggregation inhibitor. Saccharin 89-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-166 26042530-2 2015 A series of novel isoalloxazine derivatives were synthesized and biologically evaluated for their potential inhibitory outcome for both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). isoalloxazine 18-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 26042530-2 2015 A series of novel isoalloxazine derivatives were synthesized and biologically evaluated for their potential inhibitory outcome for both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). isoalloxazine 18-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 26042530-4 2015 Of the synthesized compounds, the most potent isoalloxazine derivatives (7m and 7q) showed IC50 values of 4.72 muM and 5.22 muM respectively against AChE; and, 6.98 muM and 5.29 muM respectively against BuChE. isoalloxazine 46-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 26043948-0 2015 Synthesis and in vitro kinetic evaluation of N-thiazolylacetamido monoquaternary pyridinium oximes as reactivators of sarin, O-ethylsarin and VX inhibited human acetylcholinesterase (hAChE). n-thiazolylacetamido monoquaternary pyridinium oximes 45-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-188 26043948-2 2015 In this regard, herein we report the synthesis of a series of N-thiazolylacetamide monoquaternary pyridinium oximes and its analogs (1a-1b to 6a-6b) with diversely substituted thiazole ring and evaluation of their in vitro reactivation efficacies against nerve agent (sarin, O-ethylsarin and VX) inhibited human erythrocyte acetylcholinesterase (hAChE). n-thiazolylacetamide 62-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 346-351 26043948-2 2015 In this regard, herein we report the synthesis of a series of N-thiazolylacetamide monoquaternary pyridinium oximes and its analogs (1a-1b to 6a-6b) with diversely substituted thiazole ring and evaluation of their in vitro reactivation efficacies against nerve agent (sarin, O-ethylsarin and VX) inhibited human erythrocyte acetylcholinesterase (hAChE). pyridinium oximes 98-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 346-351 26105711-0 2015 In vitro evaluation and in silico screening of synthetic acetylcholinesterase inhibitors bearing functionalized piperidine pharmacophores. piperidine 112-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 26105711-3 2015 Halogenation, nitration or 3,4-methylenedixoxy-substitution at the phenyl ring attached to the 2- and 6-positions of 1,2,5,6-tetrahydropyridine nucleus in compounds 14-17, 19, 20, 24 and 26 greatly enhanced the AChE inhibitory activity. 1,2,3,6-Tetrahydropyridine 117-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-215 25613529-12 2015 Neurochemical findings revealed that elevated cortical acetylcholinesterase level could be one of the responsible factors leading to memory deficit in phenytoin treated animals. Phenytoin 151-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 25613529-13 2015 However sodium valproate treatment reduced cortical acetylcholinesterase level and had least debilitating consequences on memory deficit. Valproic Acid 8-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 26107513-2 2015 To this end, by following a docking-assisted hybridization strategy, a number of aminocoumarins were designed, prepared, and tested as monoamine oxidases (MAOs) and acetyl- and butyryl-cholinesterase (AChE and BChE) inhibitors. Aminocoumarins 81-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 201-205 26070418-0 2015 Synthesis and in vitro kinetic study of novel mono-pyridinium oximes as reactivators of organophosphorus (OP) inhibited human acetylcholinesterase (hAChE). mono-pyridinium oximes 46-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-153 26070418-0 2015 Synthesis and in vitro kinetic study of novel mono-pyridinium oximes as reactivators of organophosphorus (OP) inhibited human acetylcholinesterase (hAChE). organophosphorus 88-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-153 26070418-7 2015 However, the synthesized oximes showed marginal reactivation efficacies in case of tabun inhibited hAChE. Oximes 25-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-104 26107513-3 2015 Highly flexible N-benzyl-N-alkyloxy coumarins 2-12 showed good inhibitory activities at MAO-B, AChE, and BChE but low selectivity. n-benzyl-n-alkyloxy coumarins 16-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 25937631-10 2015 CONCLUSION: The new adamantly derivatives selectively inhibit BChE with respect to AChE, thus making them good candidates for testing the hypothesis that BChE inhibitors would be more efficient and better tolerated than AChE inhibitors in the treatment of Alzheimer"s disease. adamantly 20-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 26870666-12 2015 The drug most frequently used for the treatment of CMS is pyridostigmine an acetylcholinesterase inhibitor. Pyridostigmine Bromide 58-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 26185179-3 2015 Clinical observations suggest that ephedrine can diminish, postpone or even prevent the need for immunosuppressive therapy when added to acetylcholinesterase inhibitors or low-dose prednisone. Ephedrine 35-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 26003339-0 2015 From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold. indacrinone 60-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 25937631-10 2015 CONCLUSION: The new adamantly derivatives selectively inhibit BChE with respect to AChE, thus making them good candidates for testing the hypothesis that BChE inhibitors would be more efficient and better tolerated than AChE inhibitors in the treatment of Alzheimer"s disease. adamantly 20-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 220-224 25956553-5 2015 RESULTS: The measurement in ANCT of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities (5.416 +- 0.501 mU/mg protein and 6.350 +- 0.599 mU/mg protein, respectively) demonstrated that upper respiratory tract is capable of controlling the availability of ACh. Acetylcholine 58-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 25869328-1 2015 Acetylcholinesterase (AChE), the enzyme that rapidly splits acetylcholine into acetate and choline, presents non-cholinergic functions through which may participate in the control of cell proliferation and apoptosis. Acetylcholine 60-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 25869328-1 2015 Acetylcholinesterase (AChE), the enzyme that rapidly splits acetylcholine into acetate and choline, presents non-cholinergic functions through which may participate in the control of cell proliferation and apoptosis. Acetylcholine 60-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 25869328-1 2015 Acetylcholinesterase (AChE), the enzyme that rapidly splits acetylcholine into acetate and choline, presents non-cholinergic functions through which may participate in the control of cell proliferation and apoptosis. Acetates 79-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 25869328-1 2015 Acetylcholinesterase (AChE), the enzyme that rapidly splits acetylcholine into acetate and choline, presents non-cholinergic functions through which may participate in the control of cell proliferation and apoptosis. Acetates 79-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 25869328-1 2015 Acetylcholinesterase (AChE), the enzyme that rapidly splits acetylcholine into acetate and choline, presents non-cholinergic functions through which may participate in the control of cell proliferation and apoptosis. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 26199915-1 2015 OBJECTIVE: Chlorpyrifos (CP) as an organophosphorus pesticide is thought to induce oxidative stress in human cells via producing reactive oxygen species (ROS) that leads to the presence of pathologic conditions due to apoptosis along with acetylcholinesterase (AChE) inhibition.This study aimed to evaluate the apoptotic effects of CP and to assess the protective potential of CeO2nanoparticle (CNP) and sodium selenite (SSe) by measuring cascades of apoptosis, oxidative stress, inflammation, and AChE inhibition in human isolated lymphocytes. Chlorpyrifos 11-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 239-259 26199915-1 2015 OBJECTIVE: Chlorpyrifos (CP) as an organophosphorus pesticide is thought to induce oxidative stress in human cells via producing reactive oxygen species (ROS) that leads to the presence of pathologic conditions due to apoptosis along with acetylcholinesterase (AChE) inhibition.This study aimed to evaluate the apoptotic effects of CP and to assess the protective potential of CeO2nanoparticle (CNP) and sodium selenite (SSe) by measuring cascades of apoptosis, oxidative stress, inflammation, and AChE inhibition in human isolated lymphocytes. Chlorpyrifos 11-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 261-265 26199915-1 2015 OBJECTIVE: Chlorpyrifos (CP) as an organophosphorus pesticide is thought to induce oxidative stress in human cells via producing reactive oxygen species (ROS) that leads to the presence of pathologic conditions due to apoptosis along with acetylcholinesterase (AChE) inhibition.This study aimed to evaluate the apoptotic effects of CP and to assess the protective potential of CeO2nanoparticle (CNP) and sodium selenite (SSe) by measuring cascades of apoptosis, oxidative stress, inflammation, and AChE inhibition in human isolated lymphocytes. Chlorpyrifos 11-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 498-502 26166237-7 2015 Donepezil hydrochloride, a reversible acetylcholinesterase inhibitor, was orally administered 5 mg/d for 6 weeks after the initial evaluation and was increased to 10 mg/d for the following 6 weeks. Donepezil 0-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 25594160-0 2015 Efficient immobilization of acetylcholinesterase onto amino functionalized carbon nanotubes for the fabrication of high sensitive organophosphorus pesticides biosensors. Carbon 75-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 25594160-0 2015 Efficient immobilization of acetylcholinesterase onto amino functionalized carbon nanotubes for the fabrication of high sensitive organophosphorus pesticides biosensors. organophosphorus 130-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 25594160-1 2015 This work introduced an efficient immobilization of acetylcholinesterase (AChE) onto amino functionalized carbon nanotubes (CNT-NH2), in order to fabricate high sensitive and practical organophosphorus pesticide (OPs) biosensors. Carbon 106-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 25594160-1 2015 This work introduced an efficient immobilization of acetylcholinesterase (AChE) onto amino functionalized carbon nanotubes (CNT-NH2), in order to fabricate high sensitive and practical organophosphorus pesticide (OPs) biosensors. Carbon 106-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 25594160-1 2015 This work introduced an efficient immobilization of acetylcholinesterase (AChE) onto amino functionalized carbon nanotubes (CNT-NH2), in order to fabricate high sensitive and practical organophosphorus pesticide (OPs) biosensors. organophosphorus 185-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 25594160-1 2015 This work introduced an efficient immobilization of acetylcholinesterase (AChE) onto amino functionalized carbon nanotubes (CNT-NH2), in order to fabricate high sensitive and practical organophosphorus pesticide (OPs) biosensors. organophosphorus 185-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 25594160-2 2015 Compared with the pristine, -COOH and -OH decorated CNTs, there were larger amount of enzymes adsorbed on the surface of CNT-NH2 with a favorable orientation and the best amperometric response was obtained on the AChE/CNT-NH2/GC electrode. Carbonic Acid 29-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 213-217 25660508-0 2015 In situ induced metal-enhanced fluorescence: a new strategy for biosensing the total acetylcholinesterase activity in sub-microliter human whole blood. Metals 16-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 25660508-1 2015 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities (i.e., total AChE) in human blood are biomarkers for theranostic monitoring of organophosphate neurotoxin-poisoned patients. Organophosphates 151-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 25660508-1 2015 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities (i.e., total AChE) in human blood are biomarkers for theranostic monitoring of organophosphate neurotoxin-poisoned patients. Organophosphates 151-166 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 25660508-2 2015 We developed an ultra-sensitive method to detect the total AChE activity in sub-microliter human whole blood based on in situ induced metal-enhanced fluorescence (MEF). Metals 134-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 25660508-3 2015 Both AChE and BChE can catalyze the hydrolysis of the acetylthiocholine (ATCh) substrate and produce positively-charged thiocholine (TCh). Acetylthiocholine 54-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 25660508-3 2015 Both AChE and BChE can catalyze the hydrolysis of the acetylthiocholine (ATCh) substrate and produce positively-charged thiocholine (TCh). Acetylthiocholine 73-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 25660508-3 2015 Both AChE and BChE can catalyze the hydrolysis of the acetylthiocholine (ATCh) substrate and produce positively-charged thiocholine (TCh). Thiocholine 60-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 25660508-3 2015 Both AChE and BChE can catalyze the hydrolysis of the acetylthiocholine (ATCh) substrate and produce positively-charged thiocholine (TCh). Thiocholine 74-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 25519498-2 2015 Confirmation that the sensor responds to changes in extracellular choline was achieved using local perfusion of choline which resulted in an increase in current, and the acetylcholinesterase inhibitor neostigmine which produced a decrease. Choline 66-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-190 25519498-2 2015 Confirmation that the sensor responds to changes in extracellular choline was achieved using local perfusion of choline which resulted in an increase in current, and the acetylcholinesterase inhibitor neostigmine which produced a decrease. Neostigmine 201-212 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-190 25914190-0 2015 Acetylcholinesterase inhibitory and antioxidant activities of novel symmetric sulfamides derived from phenethylamines. sulfamides 78-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 25914190-0 2015 Acetylcholinesterase inhibitory and antioxidant activities of novel symmetric sulfamides derived from phenethylamines. Phenethylamines 102-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 25914190-8 2015 Especially, the novel phenolic and symmetric sulfamides 16-19 showed high antioxidant and acetylcholinesterase inhibitory properties. sulfamides 45-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 25914190-9 2015 On the other hand, IC50 values were calculated for the DPPH( ), ABTS( +), DMPD( +), and O2( -) scavenging, the metal chelating, and the acetylcholinesterase inhibition effects of the novel symmetric sulfamides. 1,1-diphenyl-2-picrylhydrazyl 55-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 25956827-0 2015 Antioxidant and acetylcholinesterase inhibition properties of novel bromophenol derivatives. 2-bromophenol 68-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 25956827-1 2015 In this study, series of novel bromophenol derivatives were synthesized and investigated for their antioxidant and AChE inhibition properties. 2-bromophenol 31-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 25956827-10 2015 The results obtained from the current studies clearly show that novel bromophenol derivatives 20-24 have considerable antioxidant, antiradical, and AChE inhibition effects. 2-bromophenol 70-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 26153025-0 2015 Active Acetylcholinesterase Immobilization on a Functionalized Silicon Surface. Silicon 63-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 7-27 26153025-1 2015 In this work, we studied the attachment of active acetylcholinesterase (AChE) enzyme on a silicon substrate as a potential biomarker for the detection of organophosphorous (OP) pesticides. Silicon 90-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 26153025-1 2015 In this work, we studied the attachment of active acetylcholinesterase (AChE) enzyme on a silicon substrate as a potential biomarker for the detection of organophosphorous (OP) pesticides. Silicon 90-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 26153025-1 2015 In this work, we studied the attachment of active acetylcholinesterase (AChE) enzyme on a silicon substrate as a potential biomarker for the detection of organophosphorous (OP) pesticides. organophosphorous 154-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 26153025-1 2015 In this work, we studied the attachment of active acetylcholinesterase (AChE) enzyme on a silicon substrate as a potential biomarker for the detection of organophosphorous (OP) pesticides. organophosphorous 154-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 26153025-2 2015 A multistep functionalization strategy was developed on a crystalline silicon surface: a carboxylic acid-terminated monolayer was grafted onto a hydrogen-terminated silicon surface by photochemical hydrosilylation, and then AChE was covalently attached through amide bonds using an activation EDC/NHS process. Silicon 70-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 224-228 26153025-2 2015 A multistep functionalization strategy was developed on a crystalline silicon surface: a carboxylic acid-terminated monolayer was grafted onto a hydrogen-terminated silicon surface by photochemical hydrosilylation, and then AChE was covalently attached through amide bonds using an activation EDC/NHS process. Hydrogen 145-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 224-228 26153025-2 2015 A multistep functionalization strategy was developed on a crystalline silicon surface: a carboxylic acid-terminated monolayer was grafted onto a hydrogen-terminated silicon surface by photochemical hydrosilylation, and then AChE was covalently attached through amide bonds using an activation EDC/NHS process. Silicon 165-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 224-228 26153025-2 2015 A multistep functionalization strategy was developed on a crystalline silicon surface: a carboxylic acid-terminated monolayer was grafted onto a hydrogen-terminated silicon surface by photochemical hydrosilylation, and then AChE was covalently attached through amide bonds using an activation EDC/NHS process. Amides 261-266 acetylcholinesterase (Cartwright blood group) Homo sapiens 224-228 25712411-4 2015 Twenty four hours after administration of pralidoxime, RBC AChE activities had increased in patients in the dichlorvos and EPN groups, while RBC AChE activities had slightly decreased in the fenitrothion group. pralidoxime 42-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 25712411-4 2015 Twenty four hours after administration of pralidoxime, RBC AChE activities had increased in patients in the dichlorvos and EPN groups, while RBC AChE activities had slightly decreased in the fenitrothion group. pralidoxime 42-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 25712411-4 2015 Twenty four hours after administration of pralidoxime, RBC AChE activities had increased in patients in the dichlorvos and EPN groups, while RBC AChE activities had slightly decreased in the fenitrothion group. Fenitrothion 191-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 32262678-0 2015 Acetylcholinesterase-induced fluorescence turn-off of an oligothiophene-grafted quartz surface sensitive to myristoylcholine. oligothiophene 57-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32262678-0 2015 Acetylcholinesterase-induced fluorescence turn-off of an oligothiophene-grafted quartz surface sensitive to myristoylcholine. myristoylcholine 108-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 32262678-5 2015 The oligothiophene sensing probe retains its conformational sensitivity with regard to the AChE-mediated cleavage of MyrCh upon immobilization onto a quartz substrate, which is accomplished by a "grafting onto" approach based on click chemistry. oligothiophene 4-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 26030662-0 2015 In Vitro Inhibitory Effects of 8-O-Demethylmaritidine and Undulatine on Acetylcholinesterase and Their Predicted Penetration across the Blood-Brain Barrier. 8-demethylmaritidine 31-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 26030662-0 2015 In Vitro Inhibitory Effects of 8-O-Demethylmaritidine and Undulatine on Acetylcholinesterase and Their Predicted Penetration across the Blood-Brain Barrier. undulatine 58-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 26030662-4 2015 In this report the mechanism of AChE inhibition of two Amaryllidaceae alkaloids, 8-O-demethylmaritidine (1) and undulatine (2), and their possible penetration across the blood-brain barrier have been studied. Amaryllidaceae Alkaloids 55-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 26030662-4 2015 In this report the mechanism of AChE inhibition of two Amaryllidaceae alkaloids, 8-O-demethylmaritidine (1) and undulatine (2), and their possible penetration across the blood-brain barrier have been studied. 8-demethylmaritidine 81-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 26030662-4 2015 In this report the mechanism of AChE inhibition of two Amaryllidaceae alkaloids, 8-O-demethylmaritidine (1) and undulatine (2), and their possible penetration across the blood-brain barrier have been studied. undulatine 112-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 26100408-10 2015 Likewise, the chloroform extract exhibited the highest inhibition against both the acetylcholinesterase and butyrylcholinesterase enzymes with IC50 values of 221.13 and 82.51 mug/ml, respectively. Chloroform 14-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 25569873-2 2015 The detection mechanism is based on the facts that AuNPs quench the fluorescence of UCNPs and organophosphorus pesticides (OPs) inhibit the activity of acetylcholinesterase (AChE) which catalyzes the hydrolysis of acetylthiocholine (ATC) into thiocholine. organophosphorus 94-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 25569873-2 2015 The detection mechanism is based on the facts that AuNPs quench the fluorescence of UCNPs and organophosphorus pesticides (OPs) inhibit the activity of acetylcholinesterase (AChE) which catalyzes the hydrolysis of acetylthiocholine (ATC) into thiocholine. organophosphorus 94-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 25569873-2 2015 The detection mechanism is based on the facts that AuNPs quench the fluorescence of UCNPs and organophosphorus pesticides (OPs) inhibit the activity of acetylcholinesterase (AChE) which catalyzes the hydrolysis of acetylthiocholine (ATC) into thiocholine. OPS 123-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 25569873-2 2015 The detection mechanism is based on the facts that AuNPs quench the fluorescence of UCNPs and organophosphorus pesticides (OPs) inhibit the activity of acetylcholinesterase (AChE) which catalyzes the hydrolysis of acetylthiocholine (ATC) into thiocholine. OPS 123-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 25569873-2 2015 The detection mechanism is based on the facts that AuNPs quench the fluorescence of UCNPs and organophosphorus pesticides (OPs) inhibit the activity of acetylcholinesterase (AChE) which catalyzes the hydrolysis of acetylthiocholine (ATC) into thiocholine. Acetylthiocholine 214-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 25569873-2 2015 The detection mechanism is based on the facts that AuNPs quench the fluorescence of UCNPs and organophosphorus pesticides (OPs) inhibit the activity of acetylcholinesterase (AChE) which catalyzes the hydrolysis of acetylthiocholine (ATC) into thiocholine. Acetylthiocholine 214-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 25569873-2 2015 The detection mechanism is based on the facts that AuNPs quench the fluorescence of UCNPs and organophosphorus pesticides (OPs) inhibit the activity of acetylcholinesterase (AChE) which catalyzes the hydrolysis of acetylthiocholine (ATC) into thiocholine. Acetylthiocholine 233-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 25569873-2 2015 The detection mechanism is based on the facts that AuNPs quench the fluorescence of UCNPs and organophosphorus pesticides (OPs) inhibit the activity of acetylcholinesterase (AChE) which catalyzes the hydrolysis of acetylthiocholine (ATC) into thiocholine. Acetylthiocholine 233-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 25569873-2 2015 The detection mechanism is based on the facts that AuNPs quench the fluorescence of UCNPs and organophosphorus pesticides (OPs) inhibit the activity of acetylcholinesterase (AChE) which catalyzes the hydrolysis of acetylthiocholine (ATC) into thiocholine. Thiocholine 220-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 25569873-2 2015 The detection mechanism is based on the facts that AuNPs quench the fluorescence of UCNPs and organophosphorus pesticides (OPs) inhibit the activity of acetylcholinesterase (AChE) which catalyzes the hydrolysis of acetylthiocholine (ATC) into thiocholine. Thiocholine 220-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 25969170-2 2015 The in vitro anti-cholinesterase activity of designed compounds 7a-r against AChE and BuChE, revealed that compounds bearing piperidinylethoxy residue showed potent activity against AChE at sub-micromolar level (IC50 values = 0.122-0.207 muM), more potent than reference drug tacrine. Tacrine 276-283 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-186 25068731-1 2015 In our study, a series of new harmine derivatives has been prepared by cycloaddition reaction using various arylnitrile oxides and evaluated in vitro against acetylcholinesterase and 5-lipoxygenase enzymes, MCF7 and HCT116 cancer cell lines. Harmine 30-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-178 25068731-3 2015 The greatest activity against acetylcholinesterase (IC50 = 10.4 microM) was obtained for harmine 1 and cytotoxic activities (IC50 = 0.2 microM) for compound 3a. Harmine 89-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 27490385-1 2015 A training set of 22 synthetic galantamine derivatives binding to acetylcholinesterase was docked by GOLD and the protocol was optimized in terms of scoring function, rigidity/flexibility of the binding site, presence/absence of a water molecule inside and radius of the binding site. Galantamine 31-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 27490385-4 2015 The derived relationship was used to analyze the interactions between galantamine derivatives and AChE. Galantamine 70-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 26043064-1 2015 A series of 278 organophosphate compounds acting as acetylcholinesterase inhibitors has been studied. Organophosphates 16-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 26521443-0 2015 [Design, synthesis and evaluation of new L-proline derivatives as acetylcholinesterase inhibitors]. Proline 41-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 26521443-5 2015 So the acetylcholinesterase inhibitory activities of new L-proline derivatives were worth to be further studied. Proline 57-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 7-27 25998147-2 2015 National guidelines recommend treatment with acetylcholinesterase inhibitors (donepezil, galantamine, rivastigmine) or the N-Methyl-D-Aspartate antagonist (memantine) to reduce cognitive symptoms. Donepezil 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 25998147-2 2015 National guidelines recommend treatment with acetylcholinesterase inhibitors (donepezil, galantamine, rivastigmine) or the N-Methyl-D-Aspartate antagonist (memantine) to reduce cognitive symptoms. Galantamine 89-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 25835984-2 2015 Oxime antidotes commonly used to reactivate organophosphate inhibited AChE are ineffective against soman, while the efficacy of the recommended nerve agent bioscavenger butyrylcholinesterase is limited by strictly stoichiometric scavenging. Oximes 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 25835984-2 2015 Oxime antidotes commonly used to reactivate organophosphate inhibited AChE are ineffective against soman, while the efficacy of the recommended nerve agent bioscavenger butyrylcholinesterase is limited by strictly stoichiometric scavenging. Organophosphates 44-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 25835984-9 2015 One of the later imidazole aldoximes, RS-170B, was a 2-3-fold more effective reactivator of Y337A/F338A AChE than HI-6 due to the smaller imidazole ring, as indicated by computational molecular models, that affords a more productive angle of nucleophilic attack. imidazole 17-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 25875590-4 2015 By this method, the Michaelis constant (Km) of acetylcholinesterase was determined to be 70.60+-0.93muM and Huperzine A as an effective inhibitor of acetylcholinesterase displayed a mixed inhibition with competitive and noncompetitive inhibition behaviors. huperzine A 108-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 25875590-4 2015 By this method, the Michaelis constant (Km) of acetylcholinesterase was determined to be 70.60+-0.93muM and Huperzine A as an effective inhibitor of acetylcholinesterase displayed a mixed inhibition with competitive and noncompetitive inhibition behaviors. huperzine A 108-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-169 26095345-0 2015 Synthesis and biological evaluation of 5-benzylidenerhodanine-3-acetic acid derivatives as AChE and 15-LOX inhibitors. 5-benzylidenerhodanine-3-acetic acid 39-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 25327695-0 2015 Diurnal variation in salivary cortisol across age classes in Ache Amerindian males of Paraguay. Hydrocortisone 30-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 26095345-1 2015 A series of 5-benzylidenerhodanine-3-acetamides bearing morpholino-, 4-arylpiperazinyl-, or 4-benzylpiperidinyl- moieties were synthesized and their inhibitory activities against acetylcholinesterase (AChE) were evaluated. 5-benzylidenerhodanine-3-acetamides 12-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 179-199 26095345-1 2015 A series of 5-benzylidenerhodanine-3-acetamides bearing morpholino-, 4-arylpiperazinyl-, or 4-benzylpiperidinyl- moieties were synthesized and their inhibitory activities against acetylcholinesterase (AChE) were evaluated. 5-benzylidenerhodanine-3-acetamides 12-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 201-205 26095345-2 2015 Alteration of amide part and substitution on the benzylidene moiety resulted in change of anti-AChE activity. Amides 14-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 26095345-2 2015 Alteration of amide part and substitution on the benzylidene moiety resulted in change of anti-AChE activity. benzylidene 49-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 25812965-3 2015 Among these compounds, 14c exhibited strong inhibitory activity for AChE (IC50 values of 33.63 nM for eeAChE and 16.11 nM for hAChE) and BuChE (IC50 values of 80.72 nM for eqBuChE and 112.72 nM for hBuChE), and the highest inhibitory activity against hMAO-B (IC50 value of 0.24 muM). Carbon-14 23-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 25812965-3 2015 Among these compounds, 14c exhibited strong inhibitory activity for AChE (IC50 values of 33.63 nM for eeAChE and 16.11 nM for hAChE) and BuChE (IC50 values of 80.72 nM for eqBuChE and 112.72 nM for hBuChE), and the highest inhibitory activity against hMAO-B (IC50 value of 0.24 muM). Carbon-14 23-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-131 25812965-4 2015 Kinetic and molecular modeling studies revealed that 14c was a mixed-type inhibitor, binding simultaneously to catalytic, peripheral and mid-gorge sites of AChE. Carbon-14 53-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-160 25690270-5 2015 Donepezil is an acetylcholinesterase inhibitor approved for use across the full spectrum of mild, moderate, and severe AD. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 25690270-7 2015 The rationale for the higher dose formulation was the expected increase in acetylcholinesterase inhibition given the dose-response relationship of donepezil, with the benefits of the higher dose being most apparent in patients with more advanced AD. Donepezil 147-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 26334819-4 2015 Organophosphate resistance in mosquito is dependent on alteration in acetylcholinesterase (Ace) gene. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 25082528-1 2015 Combined in vivo and in silico studies were undertaken to gain insights into the change in mammalian brain acetylcholinesterase (AChE) activity under acute toxicity conditions in response to two representatives of organophosphates (OPs)--dichlorvos (DCV) and dimethoate (DM). Organophosphates 214-230 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 25082528-1 2015 Combined in vivo and in silico studies were undertaken to gain insights into the change in mammalian brain acetylcholinesterase (AChE) activity under acute toxicity conditions in response to two representatives of organophosphates (OPs)--dichlorvos (DCV) and dimethoate (DM). Dichlorvos 238-248 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 25082528-1 2015 Combined in vivo and in silico studies were undertaken to gain insights into the change in mammalian brain acetylcholinesterase (AChE) activity under acute toxicity conditions in response to two representatives of organophosphates (OPs)--dichlorvos (DCV) and dimethoate (DM). Dichlorvos 250-253 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 25082528-1 2015 Combined in vivo and in silico studies were undertaken to gain insights into the change in mammalian brain acetylcholinesterase (AChE) activity under acute toxicity conditions in response to two representatives of organophosphates (OPs)--dichlorvos (DCV) and dimethoate (DM). Dimethoate 259-269 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 25082528-2 2015 In vivo experiments elucidated that DCV, at multiple sublethal doses for acute time periods, markedly reduced (10-25%) AChE activity, whereas with DM intoxication, a decrease in enzyme activity appeared to be lower, that is, (2-15%), in contrast to respective normal control (100%). Dichlorvos 36-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 25082528-5 2015 The lowest binding energy obtained through the computational study strongly augment that DCV binds to brain AChE with greater affinity compared with DM with reference to G and Ki values. Dichlorvos 89-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 25764300-0 2015 Fluorescence Quenching Determination of Uranium (VI) Binding Properties by Two Functional Proteins: Acetylcholinesterase (AChE) and Vitellogenin (Vtg). uranium (vi) 40-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 25764300-0 2015 Fluorescence Quenching Determination of Uranium (VI) Binding Properties by Two Functional Proteins: Acetylcholinesterase (AChE) and Vitellogenin (Vtg). uranium (vi) 40-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 25764300-1 2015 The interactions between uranium and two functional proteins (AChE and Vtg) were investigated using fluorescence quenching measurements. Uranium 25-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 26334819-4 2015 Organophosphate resistance in mosquito is dependent on alteration in acetylcholinesterase (Ace) gene. Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-94 25649522-1 2015 Organophosphorus chemical warfare agents (OP CWAs) are potent acetylcholinesterase inhibitors that can cause incapacitation and death within minutes of exposure, and furthermore are largely undetectable by the human senses. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 25706813-2 2015 It has been reported that not ToCP itself but a metabolite of ToCP, namely, 2-(ortho-cresyl)-4H-1,2,3-benzodioxaphosphoran-2-one (CBDP), may be responsible for this effect as it can irreversibly bind to human butyrylcholinesterase (BuChE) and human acetylcholinesterase (AChE). tri-o-cresyl phosphate 62-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 249-269 25706813-2 2015 It has been reported that not ToCP itself but a metabolite of ToCP, namely, 2-(ortho-cresyl)-4H-1,2,3-benzodioxaphosphoran-2-one (CBDP), may be responsible for this effect as it can irreversibly bind to human butyrylcholinesterase (BuChE) and human acetylcholinesterase (AChE). tri-o-cresyl phosphate 62-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 271-275 25706813-2 2015 It has been reported that not ToCP itself but a metabolite of ToCP, namely, 2-(ortho-cresyl)-4H-1,2,3-benzodioxaphosphoran-2-one (CBDP), may be responsible for this effect as it can irreversibly bind to human butyrylcholinesterase (BuChE) and human acetylcholinesterase (AChE). 2-(ortho-cresyl)-4h-1,2,3-benzodioxaphosphoran-2-one 76-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 249-269 25706813-2 2015 It has been reported that not ToCP itself but a metabolite of ToCP, namely, 2-(ortho-cresyl)-4H-1,2,3-benzodioxaphosphoran-2-one (CBDP), may be responsible for this effect as it can irreversibly bind to human butyrylcholinesterase (BuChE) and human acetylcholinesterase (AChE). 2-(ortho-cresyl)-4h-1,2,3-benzodioxaphosphoran-2-one 76-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 271-275 25706813-2 2015 It has been reported that not ToCP itself but a metabolite of ToCP, namely, 2-(ortho-cresyl)-4H-1,2,3-benzodioxaphosphoran-2-one (CBDP), may be responsible for this effect as it can irreversibly bind to human butyrylcholinesterase (BuChE) and human acetylcholinesterase (AChE). CBDP 130-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 249-269 25706813-2 2015 It has been reported that not ToCP itself but a metabolite of ToCP, namely, 2-(ortho-cresyl)-4H-1,2,3-benzodioxaphosphoran-2-one (CBDP), may be responsible for this effect as it can irreversibly bind to human butyrylcholinesterase (BuChE) and human acetylcholinesterase (AChE). CBDP 130-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 271-275 25701203-4 2015 In contrast, aldoxime antidotes, the quaternary ammonium 2-PAM and tertiary amine RS-194B, showed generally similar overall reactivation kinetics, kr, in both zebrafish and human AChE. acetaldehyde oxime 13-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 179-183 25874456-1 2015 Irreversible inactivation of human acetylcholinesterase (hAChE) by organophosphorous pesticides (OPs) and chemical weapon agents (CWA) has severe morbidity and mortality consequences. organophosphorous 67-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-62 25874456-2 2015 We present data from quantum mechanics/molecular mechanics (QM/MM) and 80 classical molecular dynamics (MD) simulations of the apo and soman-adducted forms of hAChE to investigate the effects on the dynamics and protein structure when the catalytic Serine 203 is phosphonylated. Serine 249-255 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-164 25904872-4 2015 Both patients were successfully treated with the acetylcholinesterase inhibitor rivastigmine. Rivastigmine 80-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 25706320-1 2015 A newly series of coumarylthiazole derivatives containing aryl urea/thiourea groups were synthesized and their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were evaluated. Urea 63-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 25681712-0 2015 Benzofuran-derived benzylpyridinium bromides as potent acetylcholinesterase inhibitors. benzylpyridinium bromides 19-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 25681712-1 2015 A series of benzofuran-based N-benzylpyridinium derivatives 5a-o were designed and synthesized as novel AChE inhibitors. benzofuran-based n-benzylpyridinium 12-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 25681712-1 2015 A series of benzofuran-based N-benzylpyridinium derivatives 5a-o were designed and synthesized as novel AChE inhibitors. 5a-o 60-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 25681712-4 2015 The results of in vitro AChE activity evaluation of synthesized compounds revealed that all compound had potent anti-AChE activity comparable or more potent than standard drug donepezil. Donepezil 176-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 25681712-4 2015 The results of in vitro AChE activity evaluation of synthesized compounds revealed that all compound had potent anti-AChE activity comparable or more potent than standard drug donepezil. Donepezil 176-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-121 25674632-3 2015 A bienzymatic sensor for the detection of ACh was prepared by co-immobilizing choline oxidase (ChO) and acetylcholinesterase (AChE) on graphene matrix/platinum nanoparticles, and then electrodepositing them on an ITO-coated glass plate. Acetylcholine 42-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 25674632-3 2015 A bienzymatic sensor for the detection of ACh was prepared by co-immobilizing choline oxidase (ChO) and acetylcholinesterase (AChE) on graphene matrix/platinum nanoparticles, and then electrodepositing them on an ITO-coated glass plate. Graphite 135-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 25461134-0 2015 An ultra-sensitive acetylcholinesterase biosensor based on reduced graphene oxide-Au nanoparticles-beta-cyclodextrin/Prussian blue-chitosan nanocomposites for organophosphorus pesticides detection. graphene oxide 67-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 25461134-0 2015 An ultra-sensitive acetylcholinesterase biosensor based on reduced graphene oxide-Au nanoparticles-beta-cyclodextrin/Prussian blue-chitosan nanocomposites for organophosphorus pesticides detection. betadex 99-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 25461134-0 2015 An ultra-sensitive acetylcholinesterase biosensor based on reduced graphene oxide-Au nanoparticles-beta-cyclodextrin/Prussian blue-chitosan nanocomposites for organophosphorus pesticides detection. ferric ferrocyanide 117-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 25461134-0 2015 An ultra-sensitive acetylcholinesterase biosensor based on reduced graphene oxide-Au nanoparticles-beta-cyclodextrin/Prussian blue-chitosan nanocomposites for organophosphorus pesticides detection. Chitosan 131-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 25461134-0 2015 An ultra-sensitive acetylcholinesterase biosensor based on reduced graphene oxide-Au nanoparticles-beta-cyclodextrin/Prussian blue-chitosan nanocomposites for organophosphorus pesticides detection. organophosphorus 159-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 25461134-1 2015 This work reports a novel, ultrasensitive, and selective sensing platform based on a direct electrodeposition of electrochemical reduced graphene oxide (ERGO)-Au nanoparticles (AuNPs)-beta-cyclodextrin (beta-CD) and Prussian blue-chitosan (PB-CS) on glass carbon electrode (GCE) for efficiently fixed acetylcholinesterase (AChE) to fabricate organophosphorus pesticides (OPs) biosensor. graphene oxide 137-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 301-321 25461134-1 2015 This work reports a novel, ultrasensitive, and selective sensing platform based on a direct electrodeposition of electrochemical reduced graphene oxide (ERGO)-Au nanoparticles (AuNPs)-beta-cyclodextrin (beta-CD) and Prussian blue-chitosan (PB-CS) on glass carbon electrode (GCE) for efficiently fixed acetylcholinesterase (AChE) to fabricate organophosphorus pesticides (OPs) biosensor. graphene oxide 137-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 323-327 25461134-1 2015 This work reports a novel, ultrasensitive, and selective sensing platform based on a direct electrodeposition of electrochemical reduced graphene oxide (ERGO)-Au nanoparticles (AuNPs)-beta-cyclodextrin (beta-CD) and Prussian blue-chitosan (PB-CS) on glass carbon electrode (GCE) for efficiently fixed acetylcholinesterase (AChE) to fabricate organophosphorus pesticides (OPs) biosensor. ergo 153-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 301-321 25461134-1 2015 This work reports a novel, ultrasensitive, and selective sensing platform based on a direct electrodeposition of electrochemical reduced graphene oxide (ERGO)-Au nanoparticles (AuNPs)-beta-cyclodextrin (beta-CD) and Prussian blue-chitosan (PB-CS) on glass carbon electrode (GCE) for efficiently fixed acetylcholinesterase (AChE) to fabricate organophosphorus pesticides (OPs) biosensor. ergo 153-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 323-327 25461134-1 2015 This work reports a novel, ultrasensitive, and selective sensing platform based on a direct electrodeposition of electrochemical reduced graphene oxide (ERGO)-Au nanoparticles (AuNPs)-beta-cyclodextrin (beta-CD) and Prussian blue-chitosan (PB-CS) on glass carbon electrode (GCE) for efficiently fixed acetylcholinesterase (AChE) to fabricate organophosphorus pesticides (OPs) biosensor. Gold 159-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 301-321 25461134-1 2015 This work reports a novel, ultrasensitive, and selective sensing platform based on a direct electrodeposition of electrochemical reduced graphene oxide (ERGO)-Au nanoparticles (AuNPs)-beta-cyclodextrin (beta-CD) and Prussian blue-chitosan (PB-CS) on glass carbon electrode (GCE) for efficiently fixed acetylcholinesterase (AChE) to fabricate organophosphorus pesticides (OPs) biosensor. Gold 159-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 323-327 25461134-1 2015 This work reports a novel, ultrasensitive, and selective sensing platform based on a direct electrodeposition of electrochemical reduced graphene oxide (ERGO)-Au nanoparticles (AuNPs)-beta-cyclodextrin (beta-CD) and Prussian blue-chitosan (PB-CS) on glass carbon electrode (GCE) for efficiently fixed acetylcholinesterase (AChE) to fabricate organophosphorus pesticides (OPs) biosensor. betadex 203-210 acetylcholinesterase (Cartwright blood group) Homo sapiens 301-321 25461134-1 2015 This work reports a novel, ultrasensitive, and selective sensing platform based on a direct electrodeposition of electrochemical reduced graphene oxide (ERGO)-Au nanoparticles (AuNPs)-beta-cyclodextrin (beta-CD) and Prussian blue-chitosan (PB-CS) on glass carbon electrode (GCE) for efficiently fixed acetylcholinesterase (AChE) to fabricate organophosphorus pesticides (OPs) biosensor. betadex 203-210 acetylcholinesterase (Cartwright blood group) Homo sapiens 323-327 25461134-6 2015 Based on the inhibition of OPs on AChE activity, the sensor showed wide linear ranges of 7.98-2.00x10(3)pgmL(-1) and 4.3-1.00x10(3)pgmL(-1) with low detection limits of 4.14pgmL(-1) and 1.15pgmL(-1) for malathion and carbaryl, respectively. Malathion 203-212 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 25564805-11 2015 Acetylcholinesterase staining on fresh-frozen material has been found to have slightly higher rates of sensitivity and specificity when compared with hematoxylin and eosin only. Hematoxylin 150-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 25706320-1 2015 A newly series of coumarylthiazole derivatives containing aryl urea/thiourea groups were synthesized and their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were evaluated. coumarylthiazole 18-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 25706320-1 2015 A newly series of coumarylthiazole derivatives containing aryl urea/thiourea groups were synthesized and their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were evaluated. coumarylthiazole 18-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 25960230-7 2015 Finally, we have reported two compounds, OPA and OMT, which possess high affinity for catalytic site of AChE enzyme and thus, can be considered as potential AChE inhibitors for the symptomatic treatment of Alzheimer"s. omt 49-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 25960230-7 2015 Finally, we have reported two compounds, OPA and OMT, which possess high affinity for catalytic site of AChE enzyme and thus, can be considered as potential AChE inhibitors for the symptomatic treatment of Alzheimer"s. omt 49-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-161 24918348-0 2015 Synthesis and evaluation of anti-acetylcholinesterase activity of some benzothiazole based new piperazine-dithiocarbamate derivatives. benzothiazole 71-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 24918348-0 2015 Synthesis and evaluation of anti-acetylcholinesterase activity of some benzothiazole based new piperazine-dithiocarbamate derivatives. piperazine dithiocarbamate 95-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 25504063-1 2015 Organophosphorus nerve agents inhibit acetylcholinesterase (AChE) which causes the breakdown of the transmitter acetylcholine (ACh) in the synaptic cleft. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 25504063-1 2015 Organophosphorus nerve agents inhibit acetylcholinesterase (AChE) which causes the breakdown of the transmitter acetylcholine (ACh) in the synaptic cleft. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 25504063-1 2015 Organophosphorus nerve agents inhibit acetylcholinesterase (AChE) which causes the breakdown of the transmitter acetylcholine (ACh) in the synaptic cleft. Acetylcholine 38-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 25504063-1 2015 Organophosphorus nerve agents inhibit acetylcholinesterase (AChE) which causes the breakdown of the transmitter acetylcholine (ACh) in the synaptic cleft. Acetylcholine 60-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 25504063-4 2015 The presented study investigated whether 7-methoxytacrine (7-MEOTA) and 7-MEOTA-donepezil derivatives can act as central and peripheral reversible AChE inhibitors and simultaneously antagonize muscarinic and nicotinic receptors. 7-methoxytacrine 41-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 25504063-4 2015 The presented study investigated whether 7-methoxytacrine (7-MEOTA) and 7-MEOTA-donepezil derivatives can act as central and peripheral reversible AChE inhibitors and simultaneously antagonize muscarinic and nicotinic receptors. 7-methoxytacrine 59-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 25504063-4 2015 The presented study investigated whether 7-methoxytacrine (7-MEOTA) and 7-MEOTA-donepezil derivatives can act as central and peripheral reversible AChE inhibitors and simultaneously antagonize muscarinic and nicotinic receptors. 7-meota-donepezil 72-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 25504063-8 2015 In conclusion, this study provides promising evidence that the new synthesized 7-MEOTA-donepezil derivatives have the desired anticholinergic effect; they can inhibit AChE, and nicotinic and muscarinic receptors in the micromolar range. 7-meota-donepezil 79-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 24939096-1 2015 The acetylcholinesterase inhibitory and/or antitumour activities of amino-, thio- and ester-derivatives of avarol selected were evaluated for the first time at in vitro conditions. amino-, thio- and ester 68-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 24939096-1 2015 The acetylcholinesterase inhibitory and/or antitumour activities of amino-, thio- and ester-derivatives of avarol selected were evaluated for the first time at in vitro conditions. avarol 107-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 24964347-0 2015 Carbonic anhydrase and acetylcholinesterase inhibitory effects of carbamates and sulfamoylcarbamates. Carbamates 66-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 24964347-0 2015 Carbonic anhydrase and acetylcholinesterase inhibitory effects of carbamates and sulfamoylcarbamates. sulfamoylcarbamates 81-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 24964347-2 2015 In this study, a series of carbamate derivative was synthesized, and their inhibition effects on hCA I, hCA II and acetylcholinesterase (AChE) enzymes were investigated. Carbamates 27-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-135 24964347-2 2015 In this study, a series of carbamate derivative was synthesized, and their inhibition effects on hCA I, hCA II and acetylcholinesterase (AChE) enzymes were investigated. Carbamates 27-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 24964347-6 2015 The results clearly showed that both CA isoenzymes and AChE were inhibited by carbamate derivatives at the nM levels. Carbamates 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 25652185-0 2015 Acetylcholinesterase conformational states influence nitric oxide mobilization in the erythrocyte. Nitric Oxide 53-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 25652185-6 2015 In addition, the present study shows evidence that conformational changes in AChE promoted by incubation with N-19 and C-16 antibodies alter the enzyme"s functional connection to acetylcholine (ACh) (AChE-ACh complex) in an irreversible manner, resulting in impaired GSNO concentration and NO efflux from the erythrocyte. Acetylcholine 179-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 25652185-6 2015 In addition, the present study shows evidence that conformational changes in AChE promoted by incubation with N-19 and C-16 antibodies alter the enzyme"s functional connection to acetylcholine (ACh) (AChE-ACh complex) in an irreversible manner, resulting in impaired GSNO concentration and NO efflux from the erythrocyte. Acetylcholine 179-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-204 25652185-6 2015 In addition, the present study shows evidence that conformational changes in AChE promoted by incubation with N-19 and C-16 antibodies alter the enzyme"s functional connection to acetylcholine (ACh) (AChE-ACh complex) in an irreversible manner, resulting in impaired GSNO concentration and NO efflux from the erythrocyte. Acetylcholine 77-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-204 25652185-6 2015 In addition, the present study shows evidence that conformational changes in AChE promoted by incubation with N-19 and C-16 antibodies alter the enzyme"s functional connection to acetylcholine (ACh) (AChE-ACh complex) in an irreversible manner, resulting in impaired GSNO concentration and NO efflux from the erythrocyte. Acetylcholine 194-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 25652185-6 2015 In addition, the present study shows evidence that conformational changes in AChE promoted by incubation with N-19 and C-16 antibodies alter the enzyme"s functional connection to acetylcholine (ACh) (AChE-ACh complex) in an irreversible manner, resulting in impaired GSNO concentration and NO efflux from the erythrocyte. Acetylcholine 194-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-204 25652185-6 2015 In addition, the present study shows evidence that conformational changes in AChE promoted by incubation with N-19 and C-16 antibodies alter the enzyme"s functional connection to acetylcholine (ACh) (AChE-ACh complex) in an irreversible manner, resulting in impaired GSNO concentration and NO efflux from the erythrocyte. S-Nitrosoglutathione 267-271 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 25652185-6 2015 In addition, the present study shows evidence that conformational changes in AChE promoted by incubation with N-19 and C-16 antibodies alter the enzyme"s functional connection to acetylcholine (ACh) (AChE-ACh complex) in an irreversible manner, resulting in impaired GSNO concentration and NO efflux from the erythrocyte. S-Nitrosoglutathione 267-271 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-204 25712639-4 2015 Currently available treatments i.e. acetylcholinesterase inhibitors (rivastigmine, galantamine, donepezil) and N-methyl d-aspartate receptor antagonist (memantine) contribute minimal impact on the disease and target late aspects of the disease. Galantamine 83-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 25596135-6 2015 Trichlorfon and mipafox presented the lowest percentage of reactivation of inhibited NTE and the lowest ratio IC50 NTE/IC50 AChE. Trichlorfon 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 25596135-6 2015 Trichlorfon and mipafox presented the lowest percentage of reactivation of inhibited NTE and the lowest ratio IC50 NTE/IC50 AChE. mipafox 16-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 25681712-0 2015 Benzofuran-derived benzylpyridinium bromides as potent acetylcholinesterase inhibitors. benzofuran 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 25707322-4 2015 We designed the target compounds as dual binding site acetylcholinesterase inhibitors with N-benzylamine moiety interacting with the catalytic site of the enzyme and an isoindoline-1,3-dione fragment interacting with the peripheral anionic site of the enzyme. benzylamine 91-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 25707322-4 2015 We designed the target compounds as dual binding site acetylcholinesterase inhibitors with N-benzylamine moiety interacting with the catalytic site of the enzyme and an isoindoline-1,3-dione fragment interacting with the peripheral anionic site of the enzyme. 2-(3-hydroxypropyl)isoindoline-1,3-dione 169-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 32262377-7 2015 Furthermore, the presence of the acetylcholinesterase inhibitor neostigmine at concentrations as low as 1 fM was demonstrated, which is even below the necessary detection limit for clinical diagnostics. Neostigmine 64-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 25707322-4 2015 We designed the target compounds as dual binding site acetylcholinesterase inhibitors with N-benzylamine moiety interacting with the catalytic site of the enzyme and an isoindoline-1,3-dione fragment interacting with the peripheral anionic site of the enzyme. ALE 0540 181-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 25734590-3 2015 Cholinesterase inhibitors are hypothesised to work by inhibiting the enzyme acetylcholinesterase (AChE) which breaks down the neurotransmitter acetylcholine. Acetylcholine 76-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 25766324-7 2015 Blockage of AChE by huperzine A increased the trophic actions as seen in granulosa cells studies. huperzine A 20-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-16 25792802-1 2015 BACKGROUND: Donepezil is an acetylcholinesterase inhibitor indicated for Alzheimer"s disease. Donepezil 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 25621991-1 2015 The presented study describes the synthesis, pharmacological evaluation (AChE and BuChE inhibition, beta amyloid anti-aggregation effect and neuroprotective effect), molecular modeling and crystallographic studies of a novel series of isoindoline-1,3-dione derivatives. isoindoline-1,3-dione 235-256 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 25621991-4 2015 Moreover, compound 13b in addition to AChE inhibition (IC50 EeAChE = 0.219 muM) possesses additional properties, such as the ability to inhibit Abeta aggregation (65.96% at 10 muM) and a neuroprotective effect against Abeta toxicity at 1 and 3 muM. compound 13b 10-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 25636055-0 2015 Potent acetylcholinesterase inhibitors: design, synthesis, biological evaluation, and docking study of acridone linked to 1,2,3-triazole derivatives. acridone 103-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 7-27 25636055-0 2015 Potent acetylcholinesterase inhibitors: design, synthesis, biological evaluation, and docking study of acridone linked to 1,2,3-triazole derivatives. Triazoles 122-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 7-27 25636055-1 2015 A novel series of acridone linked to 1,2,3-triazole derivatives have been synthesized and evaluated in vitro for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities. acridone 18-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 25636055-1 2015 A novel series of acridone linked to 1,2,3-triazole derivatives have been synthesized and evaluated in vitro for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities. acridone 18-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 25636055-4 2015 Among the synthesized compounds, 10-((1-(4-chlorobenzyl)-1H-1,2,3-triazol-4-yl)methyl)-2-methoxyacridin-9(10H)-one 9g, depicted the most potent anti-AChE activity (IC50 = 7.31 muM). 10-((1-(4-chlorobenzyl)-1h-1,2,3-triazol-4-yl)methyl)-2-methoxyacridin-9(10h)-one 33-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 26165126-7 2015 Four of the triazolothiadiazoles exhibited excellent acetylcholinesterase inhibition activities as compared to the reference inhibitor. triazolothiadiazoles 12-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 25595305-1 2015 Organophosphosphates (OPs) are highly effective acetylcholinesterase (AChE) inhibitors that are used worldwide as cheap, multi-purpose insecticides. organophosphosphates 0-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 25595305-1 2015 Organophosphosphates (OPs) are highly effective acetylcholinesterase (AChE) inhibitors that are used worldwide as cheap, multi-purpose insecticides. organophosphosphates 0-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 25595305-1 2015 Organophosphosphates (OPs) are highly effective acetylcholinesterase (AChE) inhibitors that are used worldwide as cheap, multi-purpose insecticides. OPS 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 25595305-1 2015 Organophosphosphates (OPs) are highly effective acetylcholinesterase (AChE) inhibitors that are used worldwide as cheap, multi-purpose insecticides. OPS 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 26417364-0 2015 Paper-based acetylcholinesterase inhibition assay combining a wet system for organophosphate and carbamate pesticides detection. Organophosphates 77-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 25451328-1 2015 In this study, we employed site-directed mutagenesis to understand the role of amino acids in the gorge in oxime-induced reactivation of nerve agent-inhibited human (Hu) acetylcholinesterase (AChE). Oximes 107-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 26417364-7 2015 The absence or decrease in blue color produced by the AChE hydrolysis of indoxyl acetate can be observed in the presence of OPs and CMs. indoxyl acetate 73-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 25173731-3 2015 Under visible light irradiation, the AChE-CdSe@ZnS/graphene nanocomposite can generate a stable photocurrent and the photocurrent is found to be inversely dependent on the concentration of OPs. cdse 42-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 25173731-3 2015 Under visible light irradiation, the AChE-CdSe@ZnS/graphene nanocomposite can generate a stable photocurrent and the photocurrent is found to be inversely dependent on the concentration of OPs. Zinc 47-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 25461134-6 2015 Based on the inhibition of OPs on AChE activity, the sensor showed wide linear ranges of 7.98-2.00x10(3)pgmL(-1) and 4.3-1.00x10(3)pgmL(-1) with low detection limits of 4.14pgmL(-1) and 1.15pgmL(-1) for malathion and carbaryl, respectively. Carbaryl 217-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 25393881-5 2015 We show that the combination of melatonin with a fragment endowed with AChE inhibition in a unique chemical structure, ITH91/IQM157, can reduce neuronal cell death induced by Abeta and OA by a signaling pathway that implicates both nicotinic and melatonin receptors, PKC, Akt, ERK1/2, and induction of hemoxygenase-1. Melatonin 32-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 25173731-2 2015 The integration of CdSe@ZnS/graphene nanocomposite with biomolecules acetylcholinesterase (AChE) as a biorecognition element yields a novel biosensing platform. cdse 19-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 25173731-2 2015 The integration of CdSe@ZnS/graphene nanocomposite with biomolecules acetylcholinesterase (AChE) as a biorecognition element yields a novel biosensing platform. cdse 19-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 25173731-2 2015 The integration of CdSe@ZnS/graphene nanocomposite with biomolecules acetylcholinesterase (AChE) as a biorecognition element yields a novel biosensing platform. Zinc 24-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 25173731-2 2015 The integration of CdSe@ZnS/graphene nanocomposite with biomolecules acetylcholinesterase (AChE) as a biorecognition element yields a novel biosensing platform. Zinc 24-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 25173731-2 2015 The integration of CdSe@ZnS/graphene nanocomposite with biomolecules acetylcholinesterase (AChE) as a biorecognition element yields a novel biosensing platform. Graphite 28-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 25173731-2 2015 The integration of CdSe@ZnS/graphene nanocomposite with biomolecules acetylcholinesterase (AChE) as a biorecognition element yields a novel biosensing platform. Graphite 28-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 25881174-3 2015 For acute organophosphate pesticides (OPP) exposure, two biomarkers have been validated: plasma cholinesterase (ChE) and acetylcholinesterase (AChE) from erythrocytes. opp 38-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 25881174-3 2015 For acute organophosphate pesticides (OPP) exposure, two biomarkers have been validated: plasma cholinesterase (ChE) and acetylcholinesterase (AChE) from erythrocytes. opp 38-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 25560517-5 2015 Using acetylthiocholine (ATCh) as the substrate, this H39GFP/Cu(2+) complex-based sensor was further applied for the turn-on fluorescence detection of acetylcholinesterase (AChE) activity. Acetylthiocholine 6-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-171 25560517-5 2015 Using acetylthiocholine (ATCh) as the substrate, this H39GFP/Cu(2+) complex-based sensor was further applied for the turn-on fluorescence detection of acetylcholinesterase (AChE) activity. Acetylthiocholine 6-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-177 25560517-5 2015 Using acetylthiocholine (ATCh) as the substrate, this H39GFP/Cu(2+) complex-based sensor was further applied for the turn-on fluorescence detection of acetylcholinesterase (AChE) activity. Acetylthiocholine 25-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-171 25560517-5 2015 Using acetylthiocholine (ATCh) as the substrate, this H39GFP/Cu(2+) complex-based sensor was further applied for the turn-on fluorescence detection of acetylcholinesterase (AChE) activity. Acetylthiocholine 25-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 173-177 25560517-6 2015 The assay was based on the reaction between Cu(2+) and thiocholine, the hydrolysis product of ATCh by AChE. cupric ion 44-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 25560517-6 2015 The assay was based on the reaction between Cu(2+) and thiocholine, the hydrolysis product of ATCh by AChE. Thiocholine 55-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 25522658-0 2015 Effect of reversible ligands on oxime-induced reactivation of sarin- and cyclosarin-inhibited human acetylcholinesterase. Oximes 32-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 25522658-0 2015 Effect of reversible ligands on oxime-induced reactivation of sarin- and cyclosarin-inhibited human acetylcholinesterase. cyclohexyl methylphosphonofluoridate 73-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 25522658-1 2015 Poisoning by organophosphorus compounds (OP) used as pesticides and nerve agents is due to irreversible inhibition of the enzyme acetylcholinesterase (AChE). Organophosphorus Compounds 13-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-149 25522658-1 2015 Poisoning by organophosphorus compounds (OP) used as pesticides and nerve agents is due to irreversible inhibition of the enzyme acetylcholinesterase (AChE). Organophosphorus Compounds 13-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 25522658-4 2015 Hereby, oxime-induced reactivation of OP-inhibited non-human AChE was reported to be accelerated by different AChE-ligands. Oximes 8-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 25522658-4 2015 Hereby, oxime-induced reactivation of OP-inhibited non-human AChE was reported to be accelerated by different AChE-ligands. Oximes 8-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 25522658-5 2015 To investigate this concept with AChE from human source, the inhibitory potency, binding properties and the potential enhancement of oxime-induced reactivation of OP-inhibited AChE by structurally different AChE-ligands was assessed. Oximes 133-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 25522658-5 2015 To investigate this concept with AChE from human source, the inhibitory potency, binding properties and the potential enhancement of oxime-induced reactivation of OP-inhibited AChE by structurally different AChE-ligands was assessed. Oximes 133-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 25522658-5 2015 To investigate this concept with AChE from human source, the inhibitory potency, binding properties and the potential enhancement of oxime-induced reactivation of OP-inhibited AChE by structurally different AChE-ligands was assessed. Oximes 133-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 25522658-6 2015 Several ligands competed with the oxime for the AChE binding-site impairing reactivation of OP-inhibited AChE whereas a markedly accelerated reactivation of sarin-inhibited enzyme by obidoxime was recorded in the presence of edrophonium, galanthamine and donepezil. Oximes 34-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 25522658-6 2015 Several ligands competed with the oxime for the AChE binding-site impairing reactivation of OP-inhibited AChE whereas a markedly accelerated reactivation of sarin-inhibited enzyme by obidoxime was recorded in the presence of edrophonium, galanthamine and donepezil. Oximes 34-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 25562675-0 2015 Layer-by-layer assembled carbon nanotube-acetylcholinesterase/biopolymer renewable interfaces: SPR and electrochemical characterization. Carbon 25-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 25562675-2 2015 We report a method for the renewal of layer-by-layer (LbL) self-assembled inhibition-based enzymatic interfaces in multiwalled carbon nanotube (MWCNT) armored acetylcholinesterase (AChE) biosensors. Carbon 127-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 25562675-2 2015 We report a method for the renewal of layer-by-layer (LbL) self-assembled inhibition-based enzymatic interfaces in multiwalled carbon nanotube (MWCNT) armored acetylcholinesterase (AChE) biosensors. Carbon 127-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 25562675-8 2015 In contrast, a similar LbL assembly of soluble enzyme/polyelectrolytes resulted in stronger desorption on the surface after the alkaline treatment; this led to the investigation of AChE layer removal, permanently inhibited after pesticide exposure on glassy carbon (GC) electrodes, while keeping the cushion layers intact. Carbon 258-264 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 25455666-4 2015 Both classes inhibit acetylcholinesterase (AChE) enzymes, leading to excess acetylcholine accumulation at nerve terminals. Acetylcholine 21-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 25173731-3 2015 Under visible light irradiation, the AChE-CdSe@ZnS/graphene nanocomposite can generate a stable photocurrent and the photocurrent is found to be inversely dependent on the concentration of OPs. Graphite 51-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 26417364-0 2015 Paper-based acetylcholinesterase inhibition assay combining a wet system for organophosphate and carbamate pesticides detection. Carbamates 97-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 26417364-2 2015 Here, a paper-based sensor combined with a wet system was developed for the simple and rapid screening of organophosphate (OP) and carbamate (CM) pesticides based on the inhibition of acetylcholinesterase (AChE). Organophosphates 106-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-204 26417364-2 2015 Here, a paper-based sensor combined with a wet system was developed for the simple and rapid screening of organophosphate (OP) and carbamate (CM) pesticides based on the inhibition of acetylcholinesterase (AChE). Organophosphates 106-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 206-210 26417364-2 2015 Here, a paper-based sensor combined with a wet system was developed for the simple and rapid screening of organophosphate (OP) and carbamate (CM) pesticides based on the inhibition of acetylcholinesterase (AChE). Carbamates 131-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-204 26417364-2 2015 Here, a paper-based sensor combined with a wet system was developed for the simple and rapid screening of organophosphate (OP) and carbamate (CM) pesticides based on the inhibition of acetylcholinesterase (AChE). Carbamates 131-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 206-210 25446495-0 2015 A combined molecular docking and charge density analysis is a new approach for medicinal research to understand drug-receptor interaction: curcumin-AChE model. Curcumin 139-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 25446352-3 2015 Using the pyrithiamine-induced thiamine deficiency (PTD) rat model of human Wernicke-Korsakoff syndrome, we tested the hypothesis that co-infusion of the acetylcholinesterase inhibitor physostigmine across the PFC and HPC would recover spatial alternation performance in PTD rats. Physostigmine 185-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-174 25462245-1 2015 A new series of tacrine-based acetylcholinesterase (AChE) inhibitors 7a-l were designed by replacing the benzene ring of tacrine with aryl-dihydropyrano[2,3-c]pyrazole. Benzene 105-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 25462245-1 2015 A new series of tacrine-based acetylcholinesterase (AChE) inhibitors 7a-l were designed by replacing the benzene ring of tacrine with aryl-dihydropyrano[2,3-c]pyrazole. Tacrine 16-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 25462245-1 2015 A new series of tacrine-based acetylcholinesterase (AChE) inhibitors 7a-l were designed by replacing the benzene ring of tacrine with aryl-dihydropyrano[2,3-c]pyrazole. aryl-dihydropyrano[2,3-c]pyrazole 134-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 25462245-6 2015 The docking study of compound 7h with AChE enzyme revealed that the (R)-enantiomer binds preferably to CAS while the (S)-enantiomer prone to be a PAS binder. 7,8-diacetoxy-3-(4-nitrophenyl)coumarin 30-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 25462245-6 2015 The docking study of compound 7h with AChE enzyme revealed that the (R)-enantiomer binds preferably to CAS while the (S)-enantiomer prone to be a PAS binder. Protactinium 146-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 25446495-1 2015 In the present study, a molecular docking analysis has been performed on diketone form of curcumin molecule with acetylcholinesterase (AChE). 1,4-diselenophene-1,4-diketone 73-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 25446495-1 2015 In the present study, a molecular docking analysis has been performed on diketone form of curcumin molecule with acetylcholinesterase (AChE). Curcumin 90-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-133 25446495-1 2015 In the present study, a molecular docking analysis has been performed on diketone form of curcumin molecule with acetylcholinesterase (AChE). Curcumin 90-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 25437883-2 2015 The 3-substituted amide quinolin-2(1H)-ones not only show antibacterial activity, but also act as immunomodulators, 5-HT4 receptor agonists, cannabinoid receptor inverse agonists, and AchE and, BuchE inhibitors. 3-substituted amide 4-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-188 25437883-2 2015 The 3-substituted amide quinolin-2(1H)-ones not only show antibacterial activity, but also act as immunomodulators, 5-HT4 receptor agonists, cannabinoid receptor inverse agonists, and AchE and, BuchE inhibitors. quinolin-2(1h) 24-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-188 25446495-2 2015 The calculated lowest docked energy of curcumin molecule in the active site of AChE is -11.21 kcal/mol; this high negative value indicates that the molecule exhibits large binding affinity towards AChE. Curcumin 39-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 25446495-2 2015 The calculated lowest docked energy of curcumin molecule in the active site of AChE is -11.21 kcal/mol; this high negative value indicates that the molecule exhibits large binding affinity towards AChE. Curcumin 39-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-201 25446495-3 2015 When the curcumin molecule present in the active site of AChE, subsequently, its conformation has altered significantly and the molecule adopts a U-shape geometry as it is linear in gas phase (before entering into the active site). Curcumin 9-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 25446495-1 2015 In the present study, a molecular docking analysis has been performed on diketone form of curcumin molecule with acetylcholinesterase (AChE). 1,4-diselenophene-1,4-diketone 73-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-133 26455564-1 2015 Acetylcholinesterase is an enzyme responsible for termination of excitatory transmission at cholinergic synapses by the hydrolyzing of a neurotransmitter acetylcholine. Acetylcholine 154-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 26455564-4 2015 The mostly used therapy of Alzheimer disease is based on enhancing cholinergic function using inhibitors of acetylcholinesterase like rivastigmine, donepezil or galantamine. Rivastigmine 134-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 26455564-4 2015 The mostly used therapy of Alzheimer disease is based on enhancing cholinergic function using inhibitors of acetylcholinesterase like rivastigmine, donepezil or galantamine. Donepezil 148-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 26455564-4 2015 The mostly used therapy of Alzheimer disease is based on enhancing cholinergic function using inhibitors of acetylcholinesterase like rivastigmine, donepezil or galantamine. Galantamine 161-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 26579427-4 2015 Lineweaver-Burk plot and molecular modeling study showed that compound 4b targeted both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. Aminosalicylic Acid 153-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-165 25792271-4 2015 The AChE was immobilized on the composite electrode surface by cross-linking with glutaraldehyde and chitosan. Glutaral 82-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 25792271-4 2015 The AChE was immobilized on the composite electrode surface by cross-linking with glutaraldehyde and chitosan. Chitosan 101-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 25913282-4 2015 The sensing mechanism of this array is based on the irreversible inhibition capability of OPs and carbamates to the activity of acetylcholinesterase (AChE), preventing production of thiocholine and H2O2 from S-acetylthiocholine and acetylcholine and thus resulting in decreased or no color reactions to thiocholine and H2O2 sensitive indicators. Carbamates 98-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 25913282-4 2015 The sensing mechanism of this array is based on the irreversible inhibition capability of OPs and carbamates to the activity of acetylcholinesterase (AChE), preventing production of thiocholine and H2O2 from S-acetylthiocholine and acetylcholine and thus resulting in decreased or no color reactions to thiocholine and H2O2 sensitive indicators. Carbamates 98-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 25913282-4 2015 The sensing mechanism of this array is based on the irreversible inhibition capability of OPs and carbamates to the activity of acetylcholinesterase (AChE), preventing production of thiocholine and H2O2 from S-acetylthiocholine and acetylcholine and thus resulting in decreased or no color reactions to thiocholine and H2O2 sensitive indicators. Thiocholine 182-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 25913282-4 2015 The sensing mechanism of this array is based on the irreversible inhibition capability of OPs and carbamates to the activity of acetylcholinesterase (AChE), preventing production of thiocholine and H2O2 from S-acetylthiocholine and acetylcholine and thus resulting in decreased or no color reactions to thiocholine and H2O2 sensitive indicators. Thiocholine 182-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 25913282-4 2015 The sensing mechanism of this array is based on the irreversible inhibition capability of OPs and carbamates to the activity of acetylcholinesterase (AChE), preventing production of thiocholine and H2O2 from S-acetylthiocholine and acetylcholine and thus resulting in decreased or no color reactions to thiocholine and H2O2 sensitive indicators. Hydrogen Peroxide 198-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 25913282-4 2015 The sensing mechanism of this array is based on the irreversible inhibition capability of OPs and carbamates to the activity of acetylcholinesterase (AChE), preventing production of thiocholine and H2O2 from S-acetylthiocholine and acetylcholine and thus resulting in decreased or no color reactions to thiocholine and H2O2 sensitive indicators. Hydrogen Peroxide 198-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 25913282-4 2015 The sensing mechanism of this array is based on the irreversible inhibition capability of OPs and carbamates to the activity of acetylcholinesterase (AChE), preventing production of thiocholine and H2O2 from S-acetylthiocholine and acetylcholine and thus resulting in decreased or no color reactions to thiocholine and H2O2 sensitive indicators. Sulfur 208-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 25913282-4 2015 The sensing mechanism of this array is based on the irreversible inhibition capability of OPs and carbamates to the activity of acetylcholinesterase (AChE), preventing production of thiocholine and H2O2 from S-acetylthiocholine and acetylcholine and thus resulting in decreased or no color reactions to thiocholine and H2O2 sensitive indicators. Sulfur 208-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 25913282-4 2015 The sensing mechanism of this array is based on the irreversible inhibition capability of OPs and carbamates to the activity of acetylcholinesterase (AChE), preventing production of thiocholine and H2O2 from S-acetylthiocholine and acetylcholine and thus resulting in decreased or no color reactions to thiocholine and H2O2 sensitive indicators. Acetylthiocholine 210-227 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 25913282-4 2015 The sensing mechanism of this array is based on the irreversible inhibition capability of OPs and carbamates to the activity of acetylcholinesterase (AChE), preventing production of thiocholine and H2O2 from S-acetylthiocholine and acetylcholine and thus resulting in decreased or no color reactions to thiocholine and H2O2 sensitive indicators. Acetylthiocholine 210-227 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 25913282-4 2015 The sensing mechanism of this array is based on the irreversible inhibition capability of OPs and carbamates to the activity of acetylcholinesterase (AChE), preventing production of thiocholine and H2O2 from S-acetylthiocholine and acetylcholine and thus resulting in decreased or no color reactions to thiocholine and H2O2 sensitive indicators. Acetylcholine 128-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 25913282-4 2015 The sensing mechanism of this array is based on the irreversible inhibition capability of OPs and carbamates to the activity of acetylcholinesterase (AChE), preventing production of thiocholine and H2O2 from S-acetylthiocholine and acetylcholine and thus resulting in decreased or no color reactions to thiocholine and H2O2 sensitive indicators. Thiocholine 216-227 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 25913282-4 2015 The sensing mechanism of this array is based on the irreversible inhibition capability of OPs and carbamates to the activity of acetylcholinesterase (AChE), preventing production of thiocholine and H2O2 from S-acetylthiocholine and acetylcholine and thus resulting in decreased or no color reactions to thiocholine and H2O2 sensitive indicators. Thiocholine 216-227 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 26165279-1 2015 A microdevice for coulometric detection of organophosphate pesticides (OPs) was fabricated based on the measurement of the inhibition of an enzyme, acetylcholinesterase (AChE), by OPs. Organophosphates 43-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-168 26165279-1 2015 A microdevice for coulometric detection of organophosphate pesticides (OPs) was fabricated based on the measurement of the inhibition of an enzyme, acetylcholinesterase (AChE), by OPs. Organophosphates 43-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 26165279-2 2015 Thiocholine (TCh) produced in the enzymatic reaction of AChE with acetylthiocholine (ATCh) as a substrate was oxidized on a microelectrode array formed in a main flow channel. Thiocholine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 26165279-2 2015 Thiocholine (TCh) produced in the enzymatic reaction of AChE with acetylthiocholine (ATCh) as a substrate was oxidized on a microelectrode array formed in a main flow channel. Thiocholine 13-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 26165279-2 2015 Thiocholine (TCh) produced in the enzymatic reaction of AChE with acetylthiocholine (ATCh) as a substrate was oxidized on a microelectrode array formed in a main flow channel. Acetylthiocholine 66-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 26165279-2 2015 Thiocholine (TCh) produced in the enzymatic reaction of AChE with acetylthiocholine (ATCh) as a substrate was oxidized on a microelectrode array formed in a main flow channel. Acetylthiocholine 85-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 26460372-2 2015 The determination of an organophosphate pesticide, chlorpyrifos (CPF), was performed based on the inhibition system of the enzyme acetylcholinesterase bonded to magnetic beads through a biotin-streptavidin complex system. Organophosphates 24-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 26460372-2 2015 The determination of an organophosphate pesticide, chlorpyrifos (CPF), was performed based on the inhibition system of the enzyme acetylcholinesterase bonded to magnetic beads through a biotin-streptavidin complex system. Chlorpyrifos 51-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 26460372-2 2015 The determination of an organophosphate pesticide, chlorpyrifos (CPF), was performed based on the inhibition system of the enzyme acetylcholinesterase bonded to magnetic beads through a biotin-streptavidin complex system. Chlorpyrifos 65-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 26460372-2 2015 The determination of an organophosphate pesticide, chlorpyrifos (CPF), was performed based on the inhibition system of the enzyme acetylcholinesterase bonded to magnetic beads through a biotin-streptavidin complex system. Biotin 186-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 25913282-4 2015 The sensing mechanism of this array is based on the irreversible inhibition capability of OPs and carbamates to the activity of acetylcholinesterase (AChE), preventing production of thiocholine and H2O2 from S-acetylthiocholine and acetylcholine and thus resulting in decreased or no color reactions to thiocholine and H2O2 sensitive indicators. Hydrogen Peroxide 319-323 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 25913282-4 2015 The sensing mechanism of this array is based on the irreversible inhibition capability of OPs and carbamates to the activity of acetylcholinesterase (AChE), preventing production of thiocholine and H2O2 from S-acetylthiocholine and acetylcholine and thus resulting in decreased or no color reactions to thiocholine and H2O2 sensitive indicators. Hydrogen Peroxide 319-323 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 25685814-4 2015 In this study, we used the ZINC databank and the Lipinski"s rule of five to perform a virtual screening and a molecular docking (using Auto Dock Vina 1.1.1) aiming to select possible compounds that have quaternary ammonium atom able to inhibit acetylcholinesterase (AChE) activity. quaternary ammonium 203-222 acetylcholinesterase (Cartwright blood group) Homo sapiens 266-270 26584298-7 2015 Molecular docking revealed that compounds 6 and 7 interacted differently on AChE and BChE, by means of hydrophobic interactions and hydrogen bonding. Hydrogen 132-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 26584298-8 2015 In AChE, the indole moiety of both compounds interacted with the residues lining the peripheral anionic site, whereas in BChE, their methoxy groups are primarily responsible for the strong inhibitory activity via interactions with residues at the active site of the enzyme. indole 13-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 3-7 26648784-3 2015 The non-neuronal acetylcholine is accompanied by the expression of acetylcholinesterase and nicotinic/muscarinic acetylcholine receptors. Acetylcholine 17-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 25468034-0 2015 Synthesis of aminoalkyl-substituted aurone derivatives as acetylcholinesterase inhibitors. aminoalkyl-substituted aurone 13-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 25468034-2 2015 To date, the successful therapeutic strategy to treat AD is maintaining the levels of acetylcholine by inhibiting acetylcholinesterase (AChE). Acetylcholine 86-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 25468034-2 2015 To date, the successful therapeutic strategy to treat AD is maintaining the levels of acetylcholine by inhibiting acetylcholinesterase (AChE). Acetylcholine 86-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 25468034-3 2015 In the present study, aurone derivatives were designed and synthesized as AChE inhibitors based on the lead structure of sulfuretin. aurone 22-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 25468034-3 2015 In the present study, aurone derivatives were designed and synthesized as AChE inhibitors based on the lead structure of sulfuretin. sulfuretin 121-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 24958331-2 2015 GSNO has been regarded as a store and transporter of NO, with significant interest as a potential therapeutic agent, acting as an NO donor.NO metabolism inside the erythrocyte generates several derivatives, which can be altered by external and internal stimuli such as acetylcholine (ACh), a natural substrate of acetylcholinesterase (AChE). S-Nitrosoglutathione 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 335-339 24958331-2 2015 GSNO has been regarded as a store and transporter of NO, with significant interest as a potential therapeutic agent, acting as an NO donor.NO metabolism inside the erythrocyte generates several derivatives, which can be altered by external and internal stimuli such as acetylcholine (ACh), a natural substrate of acetylcholinesterase (AChE). Acetylcholine 269-282 acetylcholinesterase (Cartwright blood group) Homo sapiens 335-339 24958331-2 2015 GSNO has been regarded as a store and transporter of NO, with significant interest as a potential therapeutic agent, acting as an NO donor.NO metabolism inside the erythrocyte generates several derivatives, which can be altered by external and internal stimuli such as acetylcholine (ACh), a natural substrate of acetylcholinesterase (AChE). Acetylcholine 284-287 acetylcholinesterase (Cartwright blood group) Homo sapiens 335-339 24958331-4 2015 Hence, the objective of this research was to evaluate the efflux of GSNO, concomitant with the efflux of NO, after stimulation with AChE effectors. S-Nitrosoglutathione 68-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 24958331-5 2015 To achieve these goals, the in vitro effect of AChE modulators - ACh and timolol - in erythrocyte NO and GSNO were studied. Timolol 73-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 24958331-6 2015 Timolol is an erythrocyte AChE inhibitor. Timolol 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 26264921-5 2015 Currently, acetylcholinesterase (AChE) inhibitors, such as donepezil, rivastigmine and galantamine are used to treat mild to moderate AD. Donepezil 59-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 26264921-5 2015 Currently, acetylcholinesterase (AChE) inhibitors, such as donepezil, rivastigmine and galantamine are used to treat mild to moderate AD. Donepezil 59-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 26264921-5 2015 Currently, acetylcholinesterase (AChE) inhibitors, such as donepezil, rivastigmine and galantamine are used to treat mild to moderate AD. Rivastigmine 70-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 26264921-5 2015 Currently, acetylcholinesterase (AChE) inhibitors, such as donepezil, rivastigmine and galantamine are used to treat mild to moderate AD. Rivastigmine 70-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 26264921-5 2015 Currently, acetylcholinesterase (AChE) inhibitors, such as donepezil, rivastigmine and galantamine are used to treat mild to moderate AD. Galantamine 87-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 26264921-5 2015 Currently, acetylcholinesterase (AChE) inhibitors, such as donepezil, rivastigmine and galantamine are used to treat mild to moderate AD. Galantamine 87-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 26579414-1 2014 In this study two genistein derivatives (G1 and G2) are reported as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), and differences in the inhibition of AChE are described. Genistein 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 26059353-6 2015 Flavonoids, alkaloids, and xanthone compounds have been studied by various researchers (as inhibitory ligands in molecular docking; mainly with three enzymes: acetylcholinesterase (AChE; EC 3.1.1.7, butyrylcholinesterase (BChE; EC 3.1.1.8, and monoamine oxidase (MAO; EC 1.4.3.4. Flavonoids 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 26059353-6 2015 Flavonoids, alkaloids, and xanthone compounds have been studied by various researchers (as inhibitory ligands in molecular docking; mainly with three enzymes: acetylcholinesterase (AChE; EC 3.1.1.7, butyrylcholinesterase (BChE; EC 3.1.1.8, and monoamine oxidase (MAO; EC 1.4.3.4. Flavonoids 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 26059353-6 2015 Flavonoids, alkaloids, and xanthone compounds have been studied by various researchers (as inhibitory ligands in molecular docking; mainly with three enzymes: acetylcholinesterase (AChE; EC 3.1.1.7, butyrylcholinesterase (BChE; EC 3.1.1.8, and monoamine oxidase (MAO; EC 1.4.3.4. Alkaloids 12-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 26059353-6 2015 Flavonoids, alkaloids, and xanthone compounds have been studied by various researchers (as inhibitory ligands in molecular docking; mainly with three enzymes: acetylcholinesterase (AChE; EC 3.1.1.7, butyrylcholinesterase (BChE; EC 3.1.1.8, and monoamine oxidase (MAO; EC 1.4.3.4. xanthone 27-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 26059353-6 2015 Flavonoids, alkaloids, and xanthone compounds have been studied by various researchers (as inhibitory ligands in molecular docking; mainly with three enzymes: acetylcholinesterase (AChE; EC 3.1.1.7, butyrylcholinesterase (BChE; EC 3.1.1.8, and monoamine oxidase (MAO; EC 1.4.3.4. xanthone 27-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 24764253-0 2015 The inhibition of acetylcholinesterase by dantrolene and ondansetron. Dantrolene 42-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 24764253-0 2015 The inhibition of acetylcholinesterase by dantrolene and ondansetron. Ondansetron 57-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 24764253-1 2015 PURPOSE: A virtual screening study has suggested that the skeletal muscle relaxant, dantrolene, and the antiemetic drug, ondansetron, may act as inhibitors of the enzyme acetylcholinesterase (AChE). Dantrolene 84-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-190 24764253-1 2015 PURPOSE: A virtual screening study has suggested that the skeletal muscle relaxant, dantrolene, and the antiemetic drug, ondansetron, may act as inhibitors of the enzyme acetylcholinesterase (AChE). Dantrolene 84-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 24764253-1 2015 PURPOSE: A virtual screening study has suggested that the skeletal muscle relaxant, dantrolene, and the antiemetic drug, ondansetron, may act as inhibitors of the enzyme acetylcholinesterase (AChE). Ondansetron 121-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-190 24764253-1 2015 PURPOSE: A virtual screening study has suggested that the skeletal muscle relaxant, dantrolene, and the antiemetic drug, ondansetron, may act as inhibitors of the enzyme acetylcholinesterase (AChE). Ondansetron 121-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 24764253-3 2015 METHODS AND FINDINGS: Using AChE from human erythrocytes as enzyme source, it is shown that dantrolene and ondansetron inhibit AChE with IC(50) values of 12.8 microM and 37.1 microM, respectively. Dantrolene 92-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 24764253-3 2015 METHODS AND FINDINGS: Using AChE from human erythrocytes as enzyme source, it is shown that dantrolene and ondansetron inhibit AChE with IC(50) values of 12.8 microM and 37.1 microM, respectively. Dantrolene 92-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 24764253-3 2015 METHODS AND FINDINGS: Using AChE from human erythrocytes as enzyme source, it is shown that dantrolene and ondansetron inhibit AChE with IC(50) values of 12.8 microM and 37.1 microM, respectively. Ondansetron 107-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 24764253-3 2015 METHODS AND FINDINGS: Using AChE from human erythrocytes as enzyme source, it is shown that dantrolene and ondansetron inhibit AChE with IC(50) values of 12.8 microM and 37.1 microM, respectively. Ondansetron 107-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 24764253-4 2015 For comparison, the reference AChE inhibitors, tacrine and ranitidine, exhibit IC(50) values of 0.144 microM and 3.37 microM, respectively. Tacrine 47-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 24764253-4 2015 For comparison, the reference AChE inhibitors, tacrine and ranitidine, exhibit IC(50) values of 0.144 microM and 3.37 microM, respectively. Ranitidine 59-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 24764253-5 2015 By measuring the recoveries of enzyme activities after dilution of enzyme-inhibitor mixtures, it is further shown that dantrolene and ondansetron act as reversible AChE inhibitors. Dantrolene 119-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 24764253-5 2015 By measuring the recoveries of enzyme activities after dilution of enzyme-inhibitor mixtures, it is further shown that dantrolene and ondansetron act as reversible AChE inhibitors. Ondansetron 134-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 24764253-6 2015 CONCLUSIONS: By considering the typical plasma concentrations of dantrolene and ondansetron in humans at therapeutic doses, the pharmacological relevance of the AChE inhibitory potencies of these drugs is discussed. Dantrolene 65-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-165 24764253-6 2015 CONCLUSIONS: By considering the typical plasma concentrations of dantrolene and ondansetron in humans at therapeutic doses, the pharmacological relevance of the AChE inhibitory potencies of these drugs is discussed. Ondansetron 80-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-165 24764253-8 2015 The inhibition of AChE by ondansetron is therefore not of clinical relevance in humans. Ondansetron 26-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 24764253-9 2015 In contrast, after intravenous administration of dantrolene to humans, the typical plasma concentrations reached are similar to the recorded IC(50) value for the inhibition of AChE, and dantrolene may thus produce pharmacological significant inhibition of AChE. Dantrolene 49-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 24764253-9 2015 In contrast, after intravenous administration of dantrolene to humans, the typical plasma concentrations reached are similar to the recorded IC(50) value for the inhibition of AChE, and dantrolene may thus produce pharmacological significant inhibition of AChE. Dantrolene 49-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 256-260 24764253-9 2015 In contrast, after intravenous administration of dantrolene to humans, the typical plasma concentrations reached are similar to the recorded IC(50) value for the inhibition of AChE, and dantrolene may thus produce pharmacological significant inhibition of AChE. Dantrolene 186-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 24764253-9 2015 In contrast, after intravenous administration of dantrolene to humans, the typical plasma concentrations reached are similar to the recorded IC(50) value for the inhibition of AChE, and dantrolene may thus produce pharmacological significant inhibition of AChE. Dantrolene 186-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 256-260 24764253-10 2015 Further investigation is necessary to clarify the pharmacological relevance of the AChE inhibitory effect of dantrolene. Dantrolene 109-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 26728730-1 2015 A series of alkyl 2-Arylhydrazinylidene-3-oxo-3-polyfluoroalkylpropionates was synthesized and their inhibitory activity with respect to porcine liver carboxylesterase (CaE, EC 3.1.1.1), human erythrocyte acetylcholinesterase (AChE, EC 3.1.1.7), and horse serum butyrylcholinesterase (BChE, EC 3.1.1.8) was studied. alkyl 2-arylhydrazinylidene-3-oxo-3-polyfluoroalkylpropionates 12-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 227-231 25373357-0 2015 Relationships between the antidotal efficacy and structure, PK/PD parameters and bio-relevant molecular descriptors of AChE reactivating oximes: inclusion and integration to biopharmaceutical classification systems. Oximes 137-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 25373357-1 2015 INTRODUCTION: The therapeutic outcome of oximes used as reactivators of phosphorylated human acetylcholinesterase (AChE) is influenced, among other factors, by their biological distribution, their in vivo ability to achieve the nucleophilic attack and their affinity for the anionic center of the intact/inhibited AChE. Oximes 41-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 25373357-1 2015 INTRODUCTION: The therapeutic outcome of oximes used as reactivators of phosphorylated human acetylcholinesterase (AChE) is influenced, among other factors, by their biological distribution, their in vivo ability to achieve the nucleophilic attack and their affinity for the anionic center of the intact/inhibited AChE. Oximes 41-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 25373357-1 2015 INTRODUCTION: The therapeutic outcome of oximes used as reactivators of phosphorylated human acetylcholinesterase (AChE) is influenced, among other factors, by their biological distribution, their in vivo ability to achieve the nucleophilic attack and their affinity for the anionic center of the intact/inhibited AChE. Oximes 41-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 314-318 25373357-5 2015 EXPERT OPINION: The structural differences of the organophosphorus compounds (OP) and the available oximes reactivators of OP-inhibited AChE generate distinct toxicokinetic or PK profiles. organophosphorus 50-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 25373357-5 2015 EXPERT OPINION: The structural differences of the organophosphorus compounds (OP) and the available oximes reactivators of OP-inhibited AChE generate distinct toxicokinetic or PK profiles. Oximes 100-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 26061104-4 2015 PPT4 is a selective and good, noncompetitive EeAChE inhibitor, able to completely inhibit the Abeta1-40 aggregation induced by acetylcholinesterase. ppt4 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 26061104-5 2015 CONCLUSION: A new family of nonhepatotoxic showing selective acetylcholinesterase inhibition, permeable tacrine analogs have been discovered for the potential treatment of Alzheimer"s disease. Tacrine 104-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 26563788-1 2015 Both organophosphorus (OP) and carbamate insecticides inhibit acetylcholinesterase (AChE), which results in accumulation of acetylcholine (ACh) at autonomic and some central synapses and at autonomic postganglionic and neuromuscular junctions. organophosphorus 5-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 26563788-1 2015 Both organophosphorus (OP) and carbamate insecticides inhibit acetylcholinesterase (AChE), which results in accumulation of acetylcholine (ACh) at autonomic and some central synapses and at autonomic postganglionic and neuromuscular junctions. Carbamates 31-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 26563788-1 2015 Both organophosphorus (OP) and carbamate insecticides inhibit acetylcholinesterase (AChE), which results in accumulation of acetylcholine (ACh) at autonomic and some central synapses and at autonomic postganglionic and neuromuscular junctions. Acetylcholine 62-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 26563788-3 2015 With OP insecticides (but not carbamates), "aging" may also occur by partial dealkylation of the serine group at the active site of AChE; recovery of AChE activity requires synthesis of new enzyme in the liver. Serine 97-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 26639720-0 2015 Macrocyclic derivatives of 6-methyluracil: New ligands of the peripheral anionic site of acetylcholinesterase. 6-methyluracil 27-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 26639720-2 2015 The efficacy of anti-AChE drugs is based on their ability to potentiate the effects of acetylcholine (ACh) due to a decrease in the rate of AChE-catalyzed hydrolysis of ACh. Acetylcholine 87-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 26639720-2 2015 The efficacy of anti-AChE drugs is based on their ability to potentiate the effects of acetylcholine (ACh) due to a decrease in the rate of AChE-catalyzed hydrolysis of ACh. Acetylcholine 87-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 26639720-2 2015 The efficacy of anti-AChE drugs is based on their ability to potentiate the effects of acetylcholine (ACh) due to a decrease in the rate of AChE-catalyzed hydrolysis of ACh. Acetylcholine 21-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 26639720-2 2015 The efficacy of anti-AChE drugs is based on their ability to potentiate the effects of acetylcholine (ACh) due to a decrease in the rate of AChE-catalyzed hydrolysis of ACh. Acetylcholine 102-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 26639720-2 2015 The efficacy of anti-AChE drugs is based on their ability to potentiate the effects of acetylcholine (ACh) due to a decrease in the rate of AChE-catalyzed hydrolysis of ACh. Acetylcholine 102-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 26639720-13 2015 RESULTS: We described previously a new class of selective mammalian AChE vs. butyrylcholinesterase (BChE) inhibitors based on alkylammonium derivatives of 6-methyluracil of acyclic topology [7]. alkylammonium 126-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 26639720-13 2015 RESULTS: We described previously a new class of selective mammalian AChE vs. butyrylcholinesterase (BChE) inhibitors based on alkylammonium derivatives of 6-methyluracil of acyclic topology [7]. 6-methyluracil 155-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 26639720-14 2015 In the present study, taking acyclic derivatives of 6-methyluracil as a model AChE inhibitor, we attempted to develop AChE inhibitors that specifically bind to the PAS with weak binding to the active site of AChE. 6-methyluracil 52-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 26639720-14 2015 In the present study, taking acyclic derivatives of 6-methyluracil as a model AChE inhibitor, we attempted to develop AChE inhibitors that specifically bind to the PAS with weak binding to the active site of AChE. 6-methyluracil 52-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 26639720-14 2015 In the present study, taking acyclic derivatives of 6-methyluracil as a model AChE inhibitor, we attempted to develop AChE inhibitors that specifically bind to the PAS with weak binding to the active site of AChE. 6-methyluracil 52-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 26639720-14 2015 In the present study, taking acyclic derivatives of 6-methyluracil as a model AChE inhibitor, we attempted to develop AChE inhibitors that specifically bind to the PAS with weak binding to the active site of AChE. Aminosalicylic Acid 164-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 26639720-14 2015 In the present study, taking acyclic derivatives of 6-methyluracil as a model AChE inhibitor, we attempted to develop AChE inhibitors that specifically bind to the PAS with weak binding to the active site of AChE. Aminosalicylic Acid 164-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 26639720-14 2015 In the present study, taking acyclic derivatives of 6-methyluracil as a model AChE inhibitor, we attempted to develop AChE inhibitors that specifically bind to the PAS with weak binding to the active site of AChE. Aminosalicylic Acid 164-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 26639720-15 2015 We attempted to increase the size of AChE ligands to restrict specific binding to the PAS of AChE. Aminosalicylic Acid 86-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 26639720-15 2015 We attempted to increase the size of AChE ligands to restrict specific binding to the PAS of AChE. Aminosalicylic Acid 86-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 26639720-17 2015 Almost all of synthesized pyrimidinophanes inhibited AChE in the nanomolar range. pyrimidinophanes 26-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 26639720-18 2015 Based on molecular docking simulations, it was suggested that compounds bind AChE to the active center as well as to the PAS or only to the PAS. Aminosalicylic Acid 140-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 26639721-14 2015 RESULTS: During unconstrained MD, C547 very rapidly binded to the peripheral anionic site (PAS) of AChE. Aminosalicylic Acid 91-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 25408210-2 2015 Inhibition of acetylcholinesterase (AChE) in damaged but functional cholinergic synapses in the brains of dementia patients increases intrasynaptic ACh. Acetylcholine 36-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 24805972-0 2015 Oxime-dipeptides as anticholinesterase, reactivator of phosphonylated-serine of AChE catalytic triad: probing the mechanistic insight by MM-GBSA, dynamics simulations and DFT analysis. Oximes 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 24805972-0 2015 Oxime-dipeptides as anticholinesterase, reactivator of phosphonylated-serine of AChE catalytic triad: probing the mechanistic insight by MM-GBSA, dynamics simulations and DFT analysis. Dipeptides 6-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 24805972-0 2015 Oxime-dipeptides as anticholinesterase, reactivator of phosphonylated-serine of AChE catalytic triad: probing the mechanistic insight by MM-GBSA, dynamics simulations and DFT analysis. Serine 70-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 24805972-2 2015 Although lethal dose of some inhibitors cause interruption with AChE mediated mechanism but reversible AChE inhibitors can assist in protection from inhibition of AChE and hence in an aim to probe potential molecules as anticholinesterase and as reactivators, computationally structure-based approach has been exploited in this work for designing new 2-amino-3-pyridoixime-dipeptides conjugates. 2-amino-3-pyridoixime 351-372 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 24805972-2 2015 Although lethal dose of some inhibitors cause interruption with AChE mediated mechanism but reversible AChE inhibitors can assist in protection from inhibition of AChE and hence in an aim to probe potential molecules as anticholinesterase and as reactivators, computationally structure-based approach has been exploited in this work for designing new 2-amino-3-pyridoixime-dipeptides conjugates. 2-amino-3-pyridoixime 351-372 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 24805972-2 2015 Although lethal dose of some inhibitors cause interruption with AChE mediated mechanism but reversible AChE inhibitors can assist in protection from inhibition of AChE and hence in an aim to probe potential molecules as anticholinesterase and as reactivators, computationally structure-based approach has been exploited in this work for designing new 2-amino-3-pyridoixime-dipeptides conjugates. Dipeptides 373-383 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 24805972-2 2015 Although lethal dose of some inhibitors cause interruption with AChE mediated mechanism but reversible AChE inhibitors can assist in protection from inhibition of AChE and hence in an aim to probe potential molecules as anticholinesterase and as reactivators, computationally structure-based approach has been exploited in this work for designing new 2-amino-3-pyridoixime-dipeptides conjugates. Dipeptides 373-383 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 24805972-3 2015 We have combined MD simulations with flexible ligand docking approach to determine binding specificity of 2-amino-3-pyridoixime dipeptides towards AChE (PDB 2WHP). 2-amino-3-pyridoixime 106-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 24805972-3 2015 We have combined MD simulations with flexible ligand docking approach to determine binding specificity of 2-amino-3-pyridoixime dipeptides towards AChE (PDB 2WHP). Dipeptides 128-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 24805972-6 2015 The 2-amino-3-pyridoxime-(Arg-Asn) AChE systems subjected to MD simulations under explicit solvent systems with NPT and NVT ensemble. 2-amino-3-pyridoxime 4-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 24805972-6 2015 The 2-amino-3-pyridoxime-(Arg-Asn) AChE systems subjected to MD simulations under explicit solvent systems with NPT and NVT ensemble. Arg-Asn 26-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 24805972-9 2015 The pKa evaluation has revealed the major deprotonated 2-amino-3-pyridoixime species having pKa of 6.47 and hence making 2-amino-3-pyridoxime-(Arg-Asn) potential anticholinesterase and reactivator for AChE under the physiological pH. 2-amino-3-pyridoixime 55-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 201-205 24805972-9 2015 The pKa evaluation has revealed the major deprotonated 2-amino-3-pyridoixime species having pKa of 6.47 and hence making 2-amino-3-pyridoxime-(Arg-Asn) potential anticholinesterase and reactivator for AChE under the physiological pH. 2-amino-3-pyridoxime- 121-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 201-205 24805972-9 2015 The pKa evaluation has revealed the major deprotonated 2-amino-3-pyridoixime species having pKa of 6.47 and hence making 2-amino-3-pyridoxime-(Arg-Asn) potential anticholinesterase and reactivator for AChE under the physiological pH. Arg-Asn 143-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 201-205 24905476-1 2015 There is a need for continued development of acetylcholinesterase (AChE) inhibitors that could prolong the life of acetylcholine in the synaptic cleft and also prevent the aggregation of amyloid peptides associated with Alzheimer"s disease. Acetylcholine 45-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 25553088-0 2015 Upregulation of Acetylcholinesterase Mediated by p53 Contributes to Cisplatin-Induced Apoptosis in Human Breast Cancer Cell. Cisplatin 68-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 25553088-5 2015 RESULTS: In this study, the regulation of AChE expression during apoptosis induced by cisplatin, a current used anticancer drug, was investigated in human breast cancer cell line MCF-7. Cisplatin 86-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 25553088-9 2015 CONCLUSION: Taken together, these results suggested that AChE expression could be upregulated by the activation of p53 during apoptosis induced by cisplatin in MCF-7 cells. Cisplatin 147-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 25198888-0 2015 A computational insight into acetylcholinesterase inhibitory activity of a new lichen depsidone. lichen depsidone 79-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 25198888-2 2015 The recent phytochemical investigation has led to the isolation of a new depsidone 1 with moderate AChE activity (1 mug). depsidone 1 73-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 25198888-5 2015 However, the amino depsidone derivative 7, whose structure was proposed using computational approaches, is expected to be more active AChE inhibitor than the depsidone 1, due to the improved HOMO energy value. amino depsidone 13-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 25198888-5 2015 However, the amino depsidone derivative 7, whose structure was proposed using computational approaches, is expected to be more active AChE inhibitor than the depsidone 1, due to the improved HOMO energy value. depsidone 19-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 25198888-7 2015 The data presented herein support the design of novel AChE inhibitors based on the depsidone scaffold. depsidone 83-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 25431144-3 2015 It was revealed that compound 1a (N,N"-bis-(4-chloro-benzyl)-N,N"-diphenyl-oxalamide) showed maximum activity against BuChE with a half maximal inhibitory concentration (IC50) = 1.86 microM and compound 2a (but-2-enedioic acid bis-[(4-chloro-benzyl)-phenyl-amide]) exhibited optimum AChE (IC50 = 1.51 microM) inhibition with a high-selectivity index. n,n"-bis-(4-chloro-benzyl)-n,n"-diphenyl-oxalamide 34-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 283-287 25672529-0 2015 Evaluation of 2,6-dichlorophenolindophenol acetate as a substrate for acetylcholinesterase activity assay. 2,6-dichlorophenolindophenol acetate 14-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 25672529-3 2015 In the current article, 2,6-dichloroindophenol acetate is performed as a chromogenic substrate suitable for acetylcholinesterase (AChE) activity examination. 2,6-dichloroindophenol acetate 24-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 25672529-3 2015 In the current article, 2,6-dichloroindophenol acetate is performed as a chromogenic substrate suitable for acetylcholinesterase (AChE) activity examination. 2,6-dichloroindophenol acetate 24-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 25672529-6 2015 In conclusion, 2,6-dichloroindophenol acetate seems to be suitable chromogenic substrate for AChE and spectrophotometry and based on this it can be easily performed whenever AChE activity should be tested. 2,6-dichloroindophenol acetate 15-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 25672529-6 2015 In conclusion, 2,6-dichloroindophenol acetate seems to be suitable chromogenic substrate for AChE and spectrophotometry and based on this it can be easily performed whenever AChE activity should be tested. 2,6-dichloroindophenol acetate 15-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 24770900-0 2015 Mild thiamine deficiency and chronic ethanol consumption modulate acetylcholinesterase activity change and spatial memory performance in a water maze task. Thiamine 5-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 24770900-0 2015 Mild thiamine deficiency and chronic ethanol consumption modulate acetylcholinesterase activity change and spatial memory performance in a water maze task. Ethanol 37-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 24770900-2 2015 In the present work, the chronic effects of ethanol and its association to a mild thiamine deficiency episode (subclinical model) on neocortical and hippocampal acetylcholinesterase activity were assessed along with their possible association to spatial cognitive dysfunction. Ethanol 44-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-181 24770900-2 2015 In the present work, the chronic effects of ethanol and its association to a mild thiamine deficiency episode (subclinical model) on neocortical and hippocampal acetylcholinesterase activity were assessed along with their possible association to spatial cognitive dysfunction. Thiamine 82-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-181 24770900-3 2015 The results indicate that in the beginning of the neurodegenerative process, before the appearance of brain lesions, chronic ethanol consumption reverses the effects of mild thiamine deficiency on both spatial cognitive performance and acetylcholinesterase activity without having significant effects on any morphometric parameter. Ethanol 125-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 236-256 24770900-3 2015 The results indicate that in the beginning of the neurodegenerative process, before the appearance of brain lesions, chronic ethanol consumption reverses the effects of mild thiamine deficiency on both spatial cognitive performance and acetylcholinesterase activity without having significant effects on any morphometric parameter. Thiamine 174-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 236-256 25845909-0 2015 Universality of Oxime K203 for Reactivation of Nerve Agent-Inhibited AChE. oxime k203 16-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 25845909-1 2015 Oxime K203 seems to be the most promising oxime in case of reactivation of tabun-inhibited acetylcholinesterase (AChE). oxime k203 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 25845909-1 2015 Oxime K203 seems to be the most promising oxime in case of reactivation of tabun-inhibited acetylcholinesterase (AChE). Oximes 42-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 25441834-2 2015 The acute toxicity of nerve agents leads to progressive inhibition of the enzyme acetylcholinesterase (AChE) by phosphylation of serine residue at the active site of gorge. Serine 129-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 25563372-7 2015 Acetylcholinesterase (AChE) activity in the SH-SY5Y cells decreased upon incubation with GNDAs. gndas 89-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 25563372-7 2015 Acetylcholinesterase (AChE) activity in the SH-SY5Y cells decreased upon incubation with GNDAs. gndas 89-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 25563372-8 2015 Kinetic studies showed that GNDAs were able to inhibit AChE by the same mode as tacrine (9-amino-1,2,3,4-tetrahydroacridine), a known inhibitor of AChE. gndas 28-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 25563372-8 2015 Kinetic studies showed that GNDAs were able to inhibit AChE by the same mode as tacrine (9-amino-1,2,3,4-tetrahydroacridine), a known inhibitor of AChE. gndas 28-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 25563372-8 2015 Kinetic studies showed that GNDAs were able to inhibit AChE by the same mode as tacrine (9-amino-1,2,3,4-tetrahydroacridine), a known inhibitor of AChE. Tacrine 80-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 25563372-8 2015 Kinetic studies showed that GNDAs were able to inhibit AChE by the same mode as tacrine (9-amino-1,2,3,4-tetrahydroacridine), a known inhibitor of AChE. Tacrine 89-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 25563372-9 2015 A low cytotocity of GNDAs against SH-SY5Y cells could be caused by their affinity to AChE (the enzyme is localized mainly at the plasma membrane). gndas 20-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 25563372-10 2015 The interaction of GNDAs with AChE may affect their intracellular distribution and consequently the cytotoxicity. gndas 19-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 25445524-1 2014 Tacrine (THA), as the first approved acetylcholinesterase (AChE) inhibitors for the treatment of Alzheimer"s disease (AD), has been extensively investigated in last seven decades. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 25445524-1 2014 Tacrine (THA), as the first approved acetylcholinesterase (AChE) inhibitors for the treatment of Alzheimer"s disease (AD), has been extensively investigated in last seven decades. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 25445524-1 2014 Tacrine (THA), as the first approved acetylcholinesterase (AChE) inhibitors for the treatment of Alzheimer"s disease (AD), has been extensively investigated in last seven decades. Tacrine 9-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 25445524-1 2014 Tacrine (THA), as the first approved acetylcholinesterase (AChE) inhibitors for the treatment of Alzheimer"s disease (AD), has been extensively investigated in last seven decades. Tacrine 9-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 25445524-2 2014 After dimerization of THA via a 7-carbon alkyl spacer, bis(7)-tacrine (B7T) showed much potent anti-AChE activity than THA. 1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydroacridine 55-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 25445524-4 2014 According to IC50 values, the in vitro anti-AChE activities of THA dimers were up to 300-fold more potent and 200-fold more selective than that of THA. Tacrine 63-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 25445524-5 2014 In addition, the anti-AChE activities of THA dimers were found to be associated with the type and length of the linkage. Tacrine 41-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 25441834-2 2015 The acute toxicity of nerve agents leads to progressive inhibition of the enzyme acetylcholinesterase (AChE) by phosphylation of serine residue at the active site of gorge. Serine 129-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 25611730-0 2015 A neuroinformatics study to compare inhibition efficiency of three natural ligands (Fawcettimine, Cernuine and Lycodine) against human brain acetylcholinesterase. fawcettimine 84-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 25611730-0 2015 A neuroinformatics study to compare inhibition efficiency of three natural ligands (Fawcettimine, Cernuine and Lycodine) against human brain acetylcholinesterase. cernuine 98-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 25611730-0 2015 A neuroinformatics study to compare inhibition efficiency of three natural ligands (Fawcettimine, Cernuine and Lycodine) against human brain acetylcholinesterase. lycodine 111-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 25611730-2 2015 The present study elucidates molecular interactions of human brain AChE, with three natural ligands Lycodine, Cernuine and Fawcettimine for comparison. lycodine 100-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 25611730-2 2015 The present study elucidates molecular interactions of human brain AChE, with three natural ligands Lycodine, Cernuine and Fawcettimine for comparison. cernuine 110-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 25611730-2 2015 The present study elucidates molecular interactions of human brain AChE, with three natural ligands Lycodine, Cernuine and Fawcettimine for comparison. fawcettimine 123-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 25611730-4 2015 It was determined that polar and hydrophobic interactions play an important role in the correct positioning of Lycodine, Cernuine and Fawcettimine within the "catalytic site" of AChE to permit docking. lycodine 111-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-182 25611730-4 2015 It was determined that polar and hydrophobic interactions play an important role in the correct positioning of Lycodine, Cernuine and Fawcettimine within the "catalytic site" of AChE to permit docking. cernuine 121-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-182 25611730-4 2015 It was determined that polar and hydrophobic interactions play an important role in the correct positioning of Lycodine, Cernuine and Fawcettimine within the "catalytic site" of AChE to permit docking. fawcettimine 134-146 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-182 25611730-6 2015 Moreover, the present study confirms that Lycodine is a more efficient inhibitor of human brain AChE compared to Cernuine and Fawcettimine with reference to DeltaG and Ki values. lycodine 42-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 26978503-4 2015 For the first time, it has been shown that treatment of a-MCI patients with ceraxon (citicolin) results in an increase of the activity of blood serum AChE, BChE and NEP to the values observed in the CG. CITICOLINE SODIUM 76-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 26978503-4 2015 For the first time, it has been shown that treatment of a-MCI patients with ceraxon (citicolin) results in an increase of the activity of blood serum AChE, BChE and NEP to the values observed in the CG. citicolin 85-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 25038538-2 2014 Based on this phenomenon, acetylcholinesterase (AChE) and choline oxidase (ChOx) are used to catalyze ACh and choline to form the active product H2O2 and the as-produced H2O2 is detected optically. Acetylcholine 48-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 25038538-2 2014 Based on this phenomenon, acetylcholinesterase (AChE) and choline oxidase (ChOx) are used to catalyze ACh and choline to form the active product H2O2 and the as-produced H2O2 is detected optically. Choline 32-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 25038538-2 2014 Based on this phenomenon, acetylcholinesterase (AChE) and choline oxidase (ChOx) are used to catalyze ACh and choline to form the active product H2O2 and the as-produced H2O2 is detected optically. Hydrogen Peroxide 145-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 25038538-2 2014 Based on this phenomenon, acetylcholinesterase (AChE) and choline oxidase (ChOx) are used to catalyze ACh and choline to form the active product H2O2 and the as-produced H2O2 is detected optically. Hydrogen Peroxide 145-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 25038538-2 2014 Based on this phenomenon, acetylcholinesterase (AChE) and choline oxidase (ChOx) are used to catalyze ACh and choline to form the active product H2O2 and the as-produced H2O2 is detected optically. Hydrogen Peroxide 170-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 25038538-2 2014 Based on this phenomenon, acetylcholinesterase (AChE) and choline oxidase (ChOx) are used to catalyze ACh and choline to form the active product H2O2 and the as-produced H2O2 is detected optically. Hydrogen Peroxide 170-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 25453812-1 2014 Herein, we described a new class of uncharged non-pyridinium reactivators for nerve agent-inhibited acetylcholinesterase (AChE). pyridine 50-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 25453812-2 2014 Based on a dual site binding strategy, we conjugated the imidazolium aldoxime to different peripheral site ligands (PSLs) of AChE through alkyl chains. imidazolium aldoxime 57-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 25453812-3 2014 Compared with the known quaternary pyridinium reactivators, two of the resulting conjugates (7g and 7h) were highlighted to be the first efficient non-pyridinium oxime conjugates exhibiting similar or superior ability to reactivate sarin-, VX- and tabun-inhibited AChE. quaternary pyridinium 24-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 264-268 25453812-3 2014 Compared with the known quaternary pyridinium reactivators, two of the resulting conjugates (7g and 7h) were highlighted to be the first efficient non-pyridinium oxime conjugates exhibiting similar or superior ability to reactivate sarin-, VX- and tabun-inhibited AChE. pyridinium oxime 151-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 264-268 26579414-1 2014 In this study two genistein derivatives (G1 and G2) are reported as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), and differences in the inhibition of AChE are described. Genistein 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 26579414-1 2014 In this study two genistein derivatives (G1 and G2) are reported as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), and differences in the inhibition of AChE are described. Genistein 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-186 25234794-0 2014 Electrocardiographic monitoring for new prescriptions of quetiapine co-prescribed with acetylcholinesterase inhibitors or memantine from 2005 to 2009. Quetiapine Fumarate 57-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 25462993-1 2014 Novel aromatic embedded Schiff bases have been synthesized in ionic liquid [bmim]Br and evaluated in vitro for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes inhibitory activities. Schiff Bases 24-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 25462993-1 2014 Novel aromatic embedded Schiff bases have been synthesized in ionic liquid [bmim]Br and evaluated in vitro for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes inhibitory activities. Schiff Bases 24-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 25462993-2 2014 Among the newly synthesized compounds, 5f, 5h and 7j displayed higher AChE enzyme inhibitory activities than standard drug, galanthamine, with IC50 values of 1.88, 2.05 and 2.03muM, respectively. Galantamine 124-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 25370953-2 2014 It is considered that acotiamide acts as an antagonist on muscarinic autoreceptors in the enteric nervous system and inhibits acetylcholinesterase activity. Z 338 22-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 25234794-2 2014 PURPOSE: The aims of this study are to analyse, in community-dwelling people aged 65+ living in Italy"s Lombardy Region, electrocardiographic (ECG) monitoring for new users of the atypical antipsychotic quetiapine co-prescribed with acetylcholinesterase inhibitors (AChEIs) or memantine and to find independent predictors of ECG monitoring before and after the starting of this prescription. Quetiapine Fumarate 203-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-253 25111460-0 2014 Oxidized low density lipoprotein increases acetylcholinesterase activity correlating with reactive oxygen species production. Reactive Oxygen Species 90-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 26109903-7 2014 AChE was immobilized onto a cellulose matrix and indoxylacetate was used as a chromogenic substrate. Cellulose 28-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 25111460-5 2014 The increased AChE with oxidized LDLs was accompanied by a proportionate increase in intracellular ROS formation (R=0.904). Reactive Oxygen Species 99-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 25479380-0 2014 QSAR Models for the Reactivation of Sarin Inhibited AChE by Quaternary Pyridinium Oximes Based on Monte Carlo Method. quaternary pyridinium oximes 60-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 25479380-1 2014 For three random splits, one-variable models of oximes reactivation of sarin inhibited acetylcholinesterase (logarithm of the AChE reactivation percentage by oximes with concentration of 0.001 M) have been calculated with CORAL software. Oximes 48-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 24836212-1 2014 An amperometric acetylcholine biosensor was constructed by co-immobilizing covalently, a mixture of acetylcholinesterase (AChE) and choline oxidase (ChO) onto nanocomposite of chitosan (CHIT)/gold-coated ferric oxide nanoparticles (Fe@AuNPs) electrodeposited onto surface of a Au electrode and using it as a working electrode, Ag/AgCl as reference electrode and Pt wire as auxiliary electrode connected through potentiostat. Acetylcholine 16-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 25240274-0 2014 Reactions of methylphosphonic difluoride with human acetylcholinesterase and oximes--Possible therapeutic implications. methylphosphonic difluoride 13-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 25240274-3 2014 To fill this gap the reactions of DF and its main degradation product methylphosphonofluoridic acid (MF) with human acetylcholinesterase (AChE) and the oximes obidoxime, HI-6 and 2-PAM were investigated in vitro. methylphosphonfluoridate 70-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 25240274-3 2014 To fill this gap the reactions of DF and its main degradation product methylphosphonofluoridic acid (MF) with human acetylcholinesterase (AChE) and the oximes obidoxime, HI-6 and 2-PAM were investigated in vitro. methylphosphonfluoridate 70-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 25240274-3 2014 To fill this gap the reactions of DF and its main degradation product methylphosphonofluoridic acid (MF) with human acetylcholinesterase (AChE) and the oximes obidoxime, HI-6 and 2-PAM were investigated in vitro. methylphosphonfluoridate 101-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 25240274-3 2014 To fill this gap the reactions of DF and its main degradation product methylphosphonofluoridic acid (MF) with human acetylcholinesterase (AChE) and the oximes obidoxime, HI-6 and 2-PAM were investigated in vitro. methylphosphonfluoridate 101-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 25240274-5 2014 Incubation of human AChE with millimolar DF and MF and subsequent addition of obidoxime and HI-6 resulted in a concentration-dependent decrease of AChE activity. Obidoxime Chloride 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 25240274-5 2014 Incubation of human AChE with millimolar DF and MF and subsequent addition of obidoxime and HI-6 resulted in a concentration-dependent decrease of AChE activity. Obidoxime Chloride 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 25240274-5 2014 Incubation of human AChE with millimolar DF and MF and subsequent addition of obidoxime and HI-6 resulted in a concentration-dependent decrease of AChE activity. asoxime chloride 92-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 25240274-5 2014 Incubation of human AChE with millimolar DF and MF and subsequent addition of obidoxime and HI-6 resulted in a concentration-dependent decrease of AChE activity. asoxime chloride 92-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 25240274-6 2014 This effect was not observed when incubating highly diluted AChE with oximes. Oximes 70-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 24836212-1 2014 An amperometric acetylcholine biosensor was constructed by co-immobilizing covalently, a mixture of acetylcholinesterase (AChE) and choline oxidase (ChO) onto nanocomposite of chitosan (CHIT)/gold-coated ferric oxide nanoparticles (Fe@AuNPs) electrodeposited onto surface of a Au electrode and using it as a working electrode, Ag/AgCl as reference electrode and Pt wire as auxiliary electrode connected through potentiostat. Acetylcholine 16-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 24836212-2 2014 The biosensor is based on electrochemical measurement of H2O2 generated from oxidation of choline by immobilized ChO, which in turn is produced from hydrolysis of acetylcholine by immobilized AChE. Hydrogen Peroxide 57-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 24836212-2 2014 The biosensor is based on electrochemical measurement of H2O2 generated from oxidation of choline by immobilized ChO, which in turn is produced from hydrolysis of acetylcholine by immobilized AChE. Choline 90-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 24836212-2 2014 The biosensor is based on electrochemical measurement of H2O2 generated from oxidation of choline by immobilized ChO, which in turn is produced from hydrolysis of acetylcholine by immobilized AChE. Acetylcholine 163-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 25218671-0 2014 Quantum chemical and steered molecular dynamics studies for one pot solution to reactivate aged acetylcholinesterase with alkylator oxime. Oximes 132-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 25132563-2 2014 This strategy involves the reaction of ACh with acetylcholinesterase (AChE) to produce choline, which is further oxidized by choline oxidase (ChOx) to obtain betaine and H2O2. Acetylcholine 39-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 25132563-2 2014 This strategy involves the reaction of ACh with acetylcholinesterase (AChE) to produce choline, which is further oxidized by choline oxidase (ChOx) to obtain betaine and H2O2. Acetylcholine 39-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 25132563-2 2014 This strategy involves the reaction of ACh with acetylcholinesterase (AChE) to produce choline, which is further oxidized by choline oxidase (ChOx) to obtain betaine and H2O2. Choline 54-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 25132563-2 2014 This strategy involves the reaction of ACh with acetylcholinesterase (AChE) to produce choline, which is further oxidized by choline oxidase (ChOx) to obtain betaine and H2O2. Betaine 158-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 25132563-2 2014 This strategy involves the reaction of ACh with acetylcholinesterase (AChE) to produce choline, which is further oxidized by choline oxidase (ChOx) to obtain betaine and H2O2. Betaine 158-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 25132563-2 2014 This strategy involves the reaction of ACh with acetylcholinesterase (AChE) to produce choline, which is further oxidized by choline oxidase (ChOx) to obtain betaine and H2O2. Hydrogen Peroxide 170-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 25132563-2 2014 This strategy involves the reaction of ACh with acetylcholinesterase (AChE) to produce choline, which is further oxidized by choline oxidase (ChOx) to obtain betaine and H2O2. Hydrogen Peroxide 170-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 25218671-1 2014 Dimethyl(pyridin-2-yl)sulfonium based oxime has been designed to reverse the aging process of organophosphorus inhibited AChE and to reactivate the aged-AChE adduct. dimethyl(pyridin-2-yl)sulfonium based 0-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 25218671-1 2014 Dimethyl(pyridin-2-yl)sulfonium based oxime has been designed to reverse the aging process of organophosphorus inhibited AChE and to reactivate the aged-AChE adduct. dimethyl(pyridin-2-yl)sulfonium based 0-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 25218671-1 2014 Dimethyl(pyridin-2-yl)sulfonium based oxime has been designed to reverse the aging process of organophosphorus inhibited AChE and to reactivate the aged-AChE adduct. Oximes 38-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 25218671-1 2014 Dimethyl(pyridin-2-yl)sulfonium based oxime has been designed to reverse the aging process of organophosphorus inhibited AChE and to reactivate the aged-AChE adduct. Oximes 38-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 25218671-1 2014 Dimethyl(pyridin-2-yl)sulfonium based oxime has been designed to reverse the aging process of organophosphorus inhibited AChE and to reactivate the aged-AChE adduct. organophosphorus 94-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 25218671-1 2014 Dimethyl(pyridin-2-yl)sulfonium based oxime has been designed to reverse the aging process of organophosphorus inhibited AChE and to reactivate the aged-AChE adduct. organophosphorus 94-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 25218671-3 2014 The calculated free energy of activation for the methyl transfer process from designed dimethyl(phenyl)sulfonium (1) to aged AChE-OP adduct occurs with a barrier of 31.4kcal/mol at M05-2X/6-31G(*) level of theory, which is 6.4kcal/mol lower compared to the aging process signifies the preferential reversal process to recover the aged AChE-OP adduct. dimethyl(phenyl)sulfonium 87-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 25218671-3 2014 The calculated free energy of activation for the methyl transfer process from designed dimethyl(phenyl)sulfonium (1) to aged AChE-OP adduct occurs with a barrier of 31.4kcal/mol at M05-2X/6-31G(*) level of theory, which is 6.4kcal/mol lower compared to the aging process signifies the preferential reversal process to recover the aged AChE-OP adduct. dimethyl(phenyl)sulfonium 87-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 335-339 25218671-4 2014 The pyridine ring containing alkylated sulfonium species, dimethyl(pyridin-2-yl)sulfonium (2), reduced the free energy of activation by 4.4kcal/mol compared to the previously reported alkylating agent N-methyl-2-methoxypyridinium species (A) for the alkylation of aged AChE-OP adduct. pyridine 4-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 269-273 25218671-4 2014 The pyridine ring containing alkylated sulfonium species, dimethyl(pyridin-2-yl)sulfonium (2), reduced the free energy of activation by 4.4kcal/mol compared to the previously reported alkylating agent N-methyl-2-methoxypyridinium species (A) for the alkylation of aged AChE-OP adduct. alkylated sulfonium 29-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 269-273 25218671-4 2014 The pyridine ring containing alkylated sulfonium species, dimethyl(pyridin-2-yl)sulfonium (2), reduced the free energy of activation by 4.4kcal/mol compared to the previously reported alkylating agent N-methyl-2-methoxypyridinium species (A) for the alkylation of aged AChE-OP adduct. dimethyl(pyridin-2-yl)sulfonium 58-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 269-273 24493627-3 2014 This strategy could potentially maintain the positive outcomes of memantine-acetylcholinesterase inhibitor combinations, but with the benefits of a single molecule therapy. Memantine 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 25218671-4 2014 The pyridine ring containing alkylated sulfonium species, dimethyl(pyridin-2-yl)sulfonium (2), reduced the free energy of activation by 4.4kcal/mol compared to the previously reported alkylating agent N-methyl-2-methoxypyridinium species (A) for the alkylation of aged AChE-OP adduct. n-methyl-2-methoxypyridinium 201-229 acetylcholinesterase (Cartwright blood group) Homo sapiens 269-273 25218671-5 2014 The free enzyme can be liberated from the inhibited acetylcholinesterase with the sulfonium compound decorated with an oxime group to avoid the administration of oxime drugs separately. Sulfonium 82-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 25218671-5 2014 The free enzyme can be liberated from the inhibited acetylcholinesterase with the sulfonium compound decorated with an oxime group to avoid the administration of oxime drugs separately. Oximes 119-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 25218671-5 2014 The free enzyme can be liberated from the inhibited acetylcholinesterase with the sulfonium compound decorated with an oxime group to avoid the administration of oxime drugs separately. Oximes 162-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 25218671-12 2014 The computational study suggests that the newly designed oxime is a potential candidate to reactivate the aged-AChE adduct. Oximes 57-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 25260958-0 2014 Design, synthesis and pharmacological evaluation of chalcone derivatives as acetylcholinesterase inhibitors. Chalcone 52-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 25260958-1 2014 A novel series of chalcone derivatives (4a-8d) were designed, synthesized, and evaluated for the inhibition activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Chalcone 18-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 25260958-1 2014 A novel series of chalcone derivatives (4a-8d) were designed, synthesized, and evaluated for the inhibition activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Chalcone 18-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 25260958-3 2014 The most promising compound 4a (IC50: 4.68 mumol/L) was 2-fold more potent than Rivastigmine against AChE (IC50: 10.54 mumol/L) and showed a high selectivity for AChE over BuChE (ratio: 4.35). Rivastigmine 80-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 25593395-0 2014 Flavanone glycosides as acetylcholinesterase inhibitors: computational and experimental evidence. flavanone glycosides 0-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 25593395-1 2014 Acetylcholinesterase hydrolyzes the neurotransmitter called acetylcholine and is crucially involved in the regulation of neurotransmission. Acetylcholine 60-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 25593395-4 2014 They maintain the level of acetylcholine in the brain by inhibiting the acetylcholinesterase function. Acetylcholine 27-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 25593395-6 2014 In the present study, the binding potential of four flavanone glycosides such as naringin, hesperidin, poncirin and sakuranin against acetylcholinesterase was analysed by using the method of molecular modeling and docking. flavanone glycosides 52-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 25593395-6 2014 In the present study, the binding potential of four flavanone glycosides such as naringin, hesperidin, poncirin and sakuranin against acetylcholinesterase was analysed by using the method of molecular modeling and docking. naringin 81-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 25593395-6 2014 In the present study, the binding potential of four flavanone glycosides such as naringin, hesperidin, poncirin and sakuranin against acetylcholinesterase was analysed by using the method of molecular modeling and docking. Hesperidin 91-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 25324520-0 2014 In vivo imaging of human acetylcholinesterase density in peripheral organs using 11C-donepezil: dosimetry, biodistribution, and kinetic analyses. Donepezil C-11 81-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 25324520-4 2014 5-(11)C-methoxy-donepezil, a noncompetitive acetylcholinesterase ligand, was previously validated for imaging cerebral levels of acetylcholinesterase. c-methoxy-donepezil 6-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 25324520-4 2014 5-(11)C-methoxy-donepezil, a noncompetitive acetylcholinesterase ligand, was previously validated for imaging cerebral levels of acetylcholinesterase. c-methoxy-donepezil 6-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-149 25324520-5 2014 In the present study, we explored the utility of (11)C-donepezil for imaging acetylcholinesterase densities in peripheral organs, including the salivary glands, heart, stomach, intestine, pancreas, liver, and spleen. (11)c-donepezil 49-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 25324520-16 2014 CONCLUSION: (11)C-donepezil PET is suitable for imaging acetylcholinesterase densities in peripheral organs. c-donepezil 16-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 25096900-0 2014 In vitro effect of H2O 2, some transition metals and hydroxyl radical produced via fenton and fenton-like reactions, on the catalytic activity of AChE and the hydrolysis of ACh. Water 19-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 25096900-0 2014 In vitro effect of H2O 2, some transition metals and hydroxyl radical produced via fenton and fenton-like reactions, on the catalytic activity of AChE and the hydrolysis of ACh. Hydroxyl Radical 53-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 25096900-1 2014 It is well known that the principal biomolecules involved in Alzheimer"s disease (AD) are acetylcholinesterase (AChE), acetylcholine (ACh) and the amyloid beta peptide of 42 amino acid residues (Abeta42). Acetylcholine 90-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 25096900-1 2014 It is well known that the principal biomolecules involved in Alzheimer"s disease (AD) are acetylcholinesterase (AChE), acetylcholine (ACh) and the amyloid beta peptide of 42 amino acid residues (Abeta42). Acetylcholine 112-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 25096900-2 2014 ACh plays an important role in human memory and learning, but it is susceptible to hydrolysis by AChE, while the aggregation of Abeta42 forms oligomers and fibrils, which form senile plaques in the brain. Acetylcholine 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 25096900-5 2014 Therefore, we have studied in vitro how AChE catalytic activity and ACh levels are affected by the presence of metals (Fe(3+), Cu(2+), Cr(3+), Zn(2+), and Cd(2+)), H2O2 (without Abeta42), and ( ) OH radicals produced from FR and FLR. ferric sulfate 119-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 25096900-5 2014 Therefore, we have studied in vitro how AChE catalytic activity and ACh levels are affected by the presence of metals (Fe(3+), Cu(2+), Cr(3+), Zn(2+), and Cd(2+)), H2O2 (without Abeta42), and ( ) OH radicals produced from FR and FLR. cupric ion 127-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 25096900-5 2014 Therefore, we have studied in vitro how AChE catalytic activity and ACh levels are affected by the presence of metals (Fe(3+), Cu(2+), Cr(3+), Zn(2+), and Cd(2+)), H2O2 (without Abeta42), and ( ) OH radicals produced from FR and FLR. Chromium 135-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 25096900-5 2014 Therefore, we have studied in vitro how AChE catalytic activity and ACh levels are affected by the presence of metals (Fe(3+), Cu(2+), Cr(3+), Zn(2+), and Cd(2+)), H2O2 (without Abeta42), and ( ) OH radicals produced from FR and FLR. Zinc 143-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 25096900-5 2014 Therefore, we have studied in vitro how AChE catalytic activity and ACh levels are affected by the presence of metals (Fe(3+), Cu(2+), Cr(3+), Zn(2+), and Cd(2+)), H2O2 (without Abeta42), and ( ) OH radicals produced from FR and FLR. Cadmium 155-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 25096900-8 2014 This finding suggests that when H2O2, the metals and the ( )OH radicals are present, both, the AChE catalytic activity and ACh levels diminish. Hydrogen Peroxide 32-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 25096900-8 2014 This finding suggests that when H2O2, the metals and the ( )OH radicals are present, both, the AChE catalytic activity and ACh levels diminish. ( )oh radicals 57-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 25532280-0 2014 Non-competitive inhibition of acetylcholinesterase by bromotyrosine alkaloids. bromotyrosine alkaloids 54-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 25532280-3 2014 The acetylcholinesterase-inhibiting activity of all the isolated compounds were examined; to purealidin Q, isoanomoian A, aplyzanzine A, and aplysamine 2 were active with IC50 values of 1.2, 70, 104, and 1.3 muM, respectively. 167394-82-3 93-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 25532280-3 2014 The acetylcholinesterase-inhibiting activity of all the isolated compounds were examined; to purealidin Q, isoanomoian A, aplyzanzine A, and aplysamine 2 were active with IC50 values of 1.2, 70, 104, and 1.3 muM, respectively. isoanomoian a 107-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 25532280-3 2014 The acetylcholinesterase-inhibiting activity of all the isolated compounds were examined; to purealidin Q, isoanomoian A, aplyzanzine A, and aplysamine 2 were active with IC50 values of 1.2, 70, 104, and 1.3 muM, respectively. aplysamine-2 141-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 28626677-0 2015 Acetylcholinesterase enzyme inhibitor activity of some novel pyrazinamide condensed 1,2,3,4-tetrahydropyrimidines. pyrazinamide condensed 61-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 28626677-0 2015 Acetylcholinesterase enzyme inhibitor activity of some novel pyrazinamide condensed 1,2,3,4-tetrahydropyrimidines. 1,2,3,4-tetrahydropyrimidines 84-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 28626677-5 2015 Especially, compound (4l) showed the best AChE and BuChE inhibitory activity of all the 1,2,3,4-tetrahydropyrimidine derivatives, with an IC50 value of 0.11 muM and 3.4 muM. 1,2,3,4-tetrahydropyrimidine 88-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 24952230-2 2014 Cerebral acetylcholinesterase (AChE) activity, a measure of the integrity of the cholinergic system, can be assessed in vivo using positron emission tomography (PET) and [(11)C]N-methyl-4-piperidyl acetate (MP4A). N-methyl-4-piperidyl acetate 177-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-29 24952230-2 2014 Cerebral acetylcholinesterase (AChE) activity, a measure of the integrity of the cholinergic system, can be assessed in vivo using positron emission tomography (PET) and [(11)C]N-methyl-4-piperidyl acetate (MP4A). N-methyl-4-piperidyl acetate 177-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 25378907-2 2014 The 3D-quantitative structure-activity relationship study was used to define 3D-pharmacophores for inhibition of MAO A/B, acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE) enzymes and to design DPHs as novel multi-target drug candidates with potential impact in the therapy of AD. dphs 207-211 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 25378907-2 2014 The 3D-quantitative structure-activity relationship study was used to define 3D-pharmacophores for inhibition of MAO A/B, acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE) enzymes and to design DPHs as novel multi-target drug candidates with potential impact in the therapy of AD. dphs 207-211 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 25378907-3 2014 DPH14 (Electrophorus electricus AChE [EeAChE]: half maximal inhibitory concentration [IC50] =1.1+-0.3 nM; equine butyrylcholinesterase [eqBuChE]: IC50 =600+-80 nM) was 318-fold more potent for the inhibition of AChE, and 1.3-fold less potent for the inhibition of BuChE than the reference compound ASS234. dph14 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 25378907-4 2014 DPH14 is a potent human recombinant BuChE (hBuChE) inhibitor, in the same range as DPH12 or DPH16, but 13.1-fold less potent than DPH15 for the inhibition of human recombinant AChE (hAChE). dph14 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 25378907-4 2014 DPH14 is a potent human recombinant BuChE (hBuChE) inhibitor, in the same range as DPH12 or DPH16, but 13.1-fold less potent than DPH15 for the inhibition of human recombinant AChE (hAChE). dph14 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-187 25378907-5 2014 Compared with donepezil, DPH14 is almost equipotent for the inhibition of hAChE, and 8.8-fold more potent for hBuChE. dph14 25-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-79 25378907-10 2014 Novel donepezil-pyridyl hybrid DPH14 is a potent, moderately selective hAChE and selective irreversible hMAO B inhibitor which might be considered as a promising compound for further development for the treatment of AD. donepezil-pyridyl hybrid dph14 6-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-76 24786171-2 2014 Acetylcholinesterase (AChE) is a crucial enzyme in the cholinergic nerve system that hydrolyzes acetylcholine (ACh) and terminates synaptic signals by reducing the effective concentration of ACh in the synaptic clefts. Acetylcholine 96-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24786171-2 2014 Acetylcholinesterase (AChE) is a crucial enzyme in the cholinergic nerve system that hydrolyzes acetylcholine (ACh) and terminates synaptic signals by reducing the effective concentration of ACh in the synaptic clefts. Acetylcholine 96-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 24786171-2 2014 Acetylcholinesterase (AChE) is a crucial enzyme in the cholinergic nerve system that hydrolyzes acetylcholine (ACh) and terminates synaptic signals by reducing the effective concentration of ACh in the synaptic clefts. Acetylcholine 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24786171-2 2014 Acetylcholinesterase (AChE) is a crucial enzyme in the cholinergic nerve system that hydrolyzes acetylcholine (ACh) and terminates synaptic signals by reducing the effective concentration of ACh in the synaptic clefts. Acetylcholine 111-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24786171-2 2014 Acetylcholinesterase (AChE) is a crucial enzyme in the cholinergic nerve system that hydrolyzes acetylcholine (ACh) and terminates synaptic signals by reducing the effective concentration of ACh in the synaptic clefts. Acetylcholine 111-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 24786171-4 2014 By employing Born-Oppenheimer ab initio QM/MM molecular dynamics simulations with umbrella sampling, a state-of-the-art approach to simulate enzyme reactions, we have characterized the covalent inhibition mechanism between AChE and the nerve toxin soman and determined its free energy profile for the first time. oppenheimer 18-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 223-227 25672327-0 2014 Regional preparedness for mass acetylcholinesterase inhibitor poisoning through plans for stockpiling and interhospital sharing of pralidoxime. pralidoxime 131-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 25672327-2 2014 Little attention has been paid to how well regional preparedness efforts specifically affect availability of pralidoxime (2-PAM) if it were needed to treat a mass poisoning with acetylcholinesterase inhibitors (organophosphorus pesticides or nerve agents). pralidoxime 109-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-198 24770986-0 2014 Acetylcholinesterase biosensor for carbaryl detection based on interdigitated array microelectrodes. Carbaryl 35-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24770986-3 2014 Chitosan was used as the enzyme immobilization material, and AChE was used as the model enzyme for carbaryl detection to fabricate AChE biosensor. Carbaryl 99-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 24770986-3 2014 Chitosan was used as the enzyme immobilization material, and AChE was used as the model enzyme for carbaryl detection to fabricate AChE biosensor. Carbaryl 99-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 24770986-5 2014 Based on the inhibition of pesticides on the AChE activity, using carbaryl as model compounds, the biosensor exhibited a wide range, low detection limit, and high stability. Carbaryl 66-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 25190468-0 2014 Assessment of antidotal efficacy of cholinesterase reactivators against paraoxon: In vitro reactivation kinetics and physicochemical properties. Paraoxon 72-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-50 25190468-1 2014 The search of proficient oximes as reactivators of irreversibly inhibited-AChE by organophosphate poisoning necessitates an appropriate assessment of their physicochemical properties and reactivation kinetics. Oximes 25-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 25190468-1 2014 The search of proficient oximes as reactivators of irreversibly inhibited-AChE by organophosphate poisoning necessitates an appropriate assessment of their physicochemical properties and reactivation kinetics. Organophosphates 82-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 25190468-4 2014 Further the tested oximes were screened through in vitro reactivation kinetics against paraoxon-inhibited AChE. Oximes 19-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 25190468-4 2014 Further the tested oximes were screened through in vitro reactivation kinetics against paraoxon-inhibited AChE. Paraoxon 87-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 25205193-0 2014 Synthesis and acetylcholinesterase inhibitory activity of Mannich base derivatives flavokawain B. Mannich Bases 58-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 25205193-0 2014 Synthesis and acetylcholinesterase inhibitory activity of Mannich base derivatives flavokawain B. flavokawain B 83-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 25205193-1 2014 A novel series of flavokawain B derivatives, chalcone Mannich bases (4-10) were designed, synthesized, characterized, and evaluated for the inhibition activity against acetylcholinesterase (AChE). flavokawain B 18-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-188 25205193-1 2014 A novel series of flavokawain B derivatives, chalcone Mannich bases (4-10) were designed, synthesized, characterized, and evaluated for the inhibition activity against acetylcholinesterase (AChE). flavokawain B 18-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 190-194 25205193-1 2014 A novel series of flavokawain B derivatives, chalcone Mannich bases (4-10) were designed, synthesized, characterized, and evaluated for the inhibition activity against acetylcholinesterase (AChE). chalcone mannich bases 45-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 168-188 25205193-1 2014 A novel series of flavokawain B derivatives, chalcone Mannich bases (4-10) were designed, synthesized, characterized, and evaluated for the inhibition activity against acetylcholinesterase (AChE). chalcone mannich bases 45-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 190-194 25205193-3 2014 Moreover, the most promising compound 8 was 2-fold more active than rivastigmine, a well-known AChE inhibitor. Rivastigmine 68-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 24973536-2 2014 A new colorimetric method for the detection of dichlorvos based on polydiacethylene and acetylcholinesterase inhibition is developed. Dichlorvos 47-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 24973536-3 2014 The blue-to-red color transition of poly(10,12-pentacosadynoic acid) vesicles can be induced by myristoylcholine which is enzymatically hydrolyzed by acetylcholinesterase to myristic acid and choline to prevent the color transition. poly(10,12-pentacosadynoic acid) 36-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 24973536-3 2014 The blue-to-red color transition of poly(10,12-pentacosadynoic acid) vesicles can be induced by myristoylcholine which is enzymatically hydrolyzed by acetylcholinesterase to myristic acid and choline to prevent the color transition. myristoylcholine 96-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 24973536-3 2014 The blue-to-red color transition of poly(10,12-pentacosadynoic acid) vesicles can be induced by myristoylcholine which is enzymatically hydrolyzed by acetylcholinesterase to myristic acid and choline to prevent the color transition. Myristic Acid 174-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 24973536-3 2014 The blue-to-red color transition of poly(10,12-pentacosadynoic acid) vesicles can be induced by myristoylcholine which is enzymatically hydrolyzed by acetylcholinesterase to myristic acid and choline to prevent the color transition. Choline 105-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 25143139-1 2014 The inhibitory effects of flavonoids on acetylcholinesterase (AChE) have attracted great interest among researchers. Flavonoids 26-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 25143139-1 2014 The inhibitory effects of flavonoids on acetylcholinesterase (AChE) have attracted great interest among researchers. Flavonoids 26-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 25143139-2 2014 However, few reports have focused on the structure-activity relationship for AChE inhibition of flavonoids. Flavonoids 96-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 25143139-3 2014 This work mainly concerns the structural aspects of inhibitory activities and binding affinities of flavonoids as AChE inhibitors. Flavonoids 100-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 25143139-4 2014 The results show that hydroxyl groups in the A ring of flavonoids are favorable for inhibiting AChE, and the hydroxylation increases the affinities for AChE. Flavonoids 55-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 25143139-4 2014 The results show that hydroxyl groups in the A ring of flavonoids are favorable for inhibiting AChE, and the hydroxylation increases the affinities for AChE. Flavonoids 55-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 25143139-6 2014 The glycosylation decreases the AChE inhibitory activities of flavonoids and lowers the affinities for AChE by 1 to 5 times depending on the conjunction site and the type of sugar moiety. Flavonoids 62-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 25143139-6 2014 The glycosylation decreases the AChE inhibitory activities of flavonoids and lowers the affinities for AChE by 1 to 5 times depending on the conjunction site and the type of sugar moiety. Sugars 174-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 25143139-8 2014 The molecular property-affinity relationship reveals that the hydrogen bond force plays an important role in binding flavonoids to AChE. Hydrogen 62-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 25143139-8 2014 The molecular property-affinity relationship reveals that the hydrogen bond force plays an important role in binding flavonoids to AChE. Flavonoids 117-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 25143139-9 2014 The AChE inhibitions generally increase with the increasing affinities of flavonoids within the class, especially for flavones and flavonols. Flavonoids 74-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 25143139-9 2014 The AChE inhibitions generally increase with the increasing affinities of flavonoids within the class, especially for flavones and flavonols. Flavones 118-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 25143139-9 2014 The AChE inhibitions generally increase with the increasing affinities of flavonoids within the class, especially for flavones and flavonols. Flavonols 131-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 24321276-3 2014 Herein is presented the results of selective screening assays of a coumarin derivatives library using BChE and AChE covalently immobilized onto silica fused capillaries (ICERs, 15 cm x 0.1 mm ID). coumarin 67-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 24321276-3 2014 Herein is presented the results of selective screening assays of a coumarin derivatives library using BChE and AChE covalently immobilized onto silica fused capillaries (ICERs, 15 cm x 0.1 mm ID). Silicon Dioxide 144-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 24321276-5 2014 Two out of 20 coumarin derivatives could be highlighted: compound 17 is more active toward BChE (IC50=109 +- 21 muM) and 19 showed activity against both enzymes (BChE IC50=128 +- 28 muM and hu-AChE IC50=144 +- 40 muM). coumarin 14-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-197 25352723-3 2014 Therefore, it is of interest to evaluate the importance of fisetin (a flavonol that belongs to the flavonoid group of polyphenols) binding with AChE, ABAD and BACE1 proteins. fisetin 59-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 25484499-1 2014 Donepezil, an acetylcholinesterase inhibitor, is approved for the treatment of mild to moderate dementia secondary to Alzheimer"s disease. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 25352723-3 2014 Therefore, it is of interest to evaluate the importance of fisetin (a flavonol that belongs to the flavonoid group of polyphenols) binding with AChE, ABAD and BACE1 proteins. 3-hydroxyflavone 70-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 25271427-0 2014 New derivatives of 3,4-dihydroisoquinoline-3-carboxylic acid with free-radical scavenging, D-amino acid oxidase, acetylcholinesterase and butyrylcholinesterase inhibitory activity. SCHEMBL16431429 19-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-133 25050413-3 2014 The AChE-catalyzed hydrolysis of ATC releases thiocholine to cause the aggregation of the AuNCs towards a dramatic decrease in fluorescence intensities, which could be curbed by the phosphorylation-induced inhibition of AChE activity when exposed to organophosphorus compounds (OPs). Thiocholine 46-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 25050413-3 2014 The AChE-catalyzed hydrolysis of ATC releases thiocholine to cause the aggregation of the AuNCs towards a dramatic decrease in fluorescence intensities, which could be curbed by the phosphorylation-induced inhibition of AChE activity when exposed to organophosphorus compounds (OPs). Thiocholine 46-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 220-224 25050413-3 2014 The AChE-catalyzed hydrolysis of ATC releases thiocholine to cause the aggregation of the AuNCs towards a dramatic decrease in fluorescence intensities, which could be curbed by the phosphorylation-induced inhibition of AChE activity when exposed to organophosphorus compounds (OPs). Organophosphorus Compounds 250-276 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 25050413-3 2014 The AChE-catalyzed hydrolysis of ATC releases thiocholine to cause the aggregation of the AuNCs towards a dramatic decrease in fluorescence intensities, which could be curbed by the phosphorylation-induced inhibition of AChE activity when exposed to organophosphorus compounds (OPs). Organophosphorus Compounds 250-276 acetylcholinesterase (Cartwright blood group) Homo sapiens 220-224 25050413-3 2014 The AChE-catalyzed hydrolysis of ATC releases thiocholine to cause the aggregation of the AuNCs towards a dramatic decrease in fluorescence intensities, which could be curbed by the phosphorylation-induced inhibition of AChE activity when exposed to organophosphorus compounds (OPs). Organophosphorus Compounds 278-281 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 25050413-3 2014 The AChE-catalyzed hydrolysis of ATC releases thiocholine to cause the aggregation of the AuNCs towards a dramatic decrease in fluorescence intensities, which could be curbed by the phosphorylation-induced inhibition of AChE activity when exposed to organophosphorus compounds (OPs). Organophosphorus Compounds 278-281 acetylcholinesterase (Cartwright blood group) Homo sapiens 220-224 25050480-1 2014 An acetylcholinesterase-immobilized sensor unit was successfully prepared by encapsulating the enzyme within hybrid mesoporous silica membranes (F127-MST). Silicon Dioxide 127-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 3-23 25016233-2 2014 The tetra-, penta-, and octamethylene-linked homologues 5b-d have been also synthesized for comparison purposes, and found to retain the nanomolar hAChE inhibitory potency of the parent 6-chlorotacrine. tetra-, penta-, and octamethylene 4-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-152 25220382-1 2014 BACKGROUND: Acetylcholinesterase (AChE) mainly functions as an efficient terminator for acetylcholine signaling transmission. Acetylcholine 88-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-32 25220382-1 2014 BACKGROUND: Acetylcholinesterase (AChE) mainly functions as an efficient terminator for acetylcholine signaling transmission. Acetylcholine 88-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 25220382-4 2014 Gastric cancer cells were treated with AChE delivered by replication-deficient adenoviral vector (Ad.AChE) or oncolytic adenoviral vector (ZD55-AChE), respectively, followed by measurement of cell viability and apoptosis by MTT assay and apoptosis detection assays. monooxyethylene trimethylolpropane tristearate 224-227 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 25220382-6 2014 In addition, the cell viability of gastric cancer stem cells treated with Ad.AChE or ZD55-AChE were evaluated by MTT assay. monooxyethylene trimethylolpropane tristearate 113-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 25220382-8 2014 Ad.AChE and ZD55-AChE inhibited gastric cancer cell growth, and low dose of ZD55-AChE induced mitochondrial pathway of apoptosis in cells. zd55 12-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 25220382-8 2014 Ad.AChE and ZD55-AChE inhibited gastric cancer cell growth, and low dose of ZD55-AChE induced mitochondrial pathway of apoptosis in cells. zd55 12-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 25130420-2 2014 In this work, a reaction-based photonic strategy was developed for the efficient assay of AChE activity and inhibition based on the synergetic combination of the specific thiol-maleimide addition reaction with photonic porous structure. thiol-maleimide 171-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 25186736-5 2014 We found that BChE is anchored at the TSC by a proline-rich membrane anchor, the small transmembrane protein anchor of brain AChE. Proline 47-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 25239202-0 2014 QSAR analysis on tacrine-related acetylcholinesterase inhibitors. Tacrine 17-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 25239202-2 2014 The study of tacrine analogs presents a continuous interest, and for this reason we establish Quantitative Structure-Activity Relationships on their Acetylcholinesterase inhibitory activity. Tacrine 13-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-169 25239202-3 2014 RESULTS: Ten groups of new developed Tacrine-related inhibitors are explored, which have been experimentally measured in different biochemical conditions and AChE sources. Tacrine 37-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 25047936-0 2014 Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with "inverted" binding mode. Amines 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 25047936-0 2014 Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with "inverted" binding mode. Quinazolinones 22-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 25059502-1 2014 A series of cyclic acyl guanidine with carbamate moieties have been synthesized and evaluated in vitro for their AChE and BChE inhibitory activities. cyclic acyl guanidine 12-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 25082512-3 2014 Among all the compounds, 6a demonstrated the most potent AChE inhibition with IC50 value of 0.097muM, which is about 20-fold than that of rivastigmine. Rivastigmine 138-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 25088549-0 2014 Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Abeta aggregation, and beta-secretase. coumarin 13-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 25088549-1 2014 Exploring small-molecule acetylcholinesterase (AChE) inhibitors to slow the breakdown of acetylcholine (Ach) represents the mainstream direction for Alzheimer"s disease (AD) therapy. Acetylcholine 25-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 25088549-1 2014 Exploring small-molecule acetylcholinesterase (AChE) inhibitors to slow the breakdown of acetylcholine (Ach) represents the mainstream direction for Alzheimer"s disease (AD) therapy. Acetylcholine 104-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 25088549-1 2014 Exploring small-molecule acetylcholinesterase (AChE) inhibitors to slow the breakdown of acetylcholine (Ach) represents the mainstream direction for Alzheimer"s disease (AD) therapy. Acetylcholine 104-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 25088549-2 2014 As the first acetylcholinesterase inhibitor approved for the clinical treatment of AD, tacrine has been widely used as a pharmacophore to design hybrid compounds in order to combine its potent AChE inhibition with other multi-target profiles. Tacrine 87-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-33 25088549-2 2014 As the first acetylcholinesterase inhibitor approved for the clinical treatment of AD, tacrine has been widely used as a pharmacophore to design hybrid compounds in order to combine its potent AChE inhibition with other multi-target profiles. Tacrine 87-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-197 25088549-3 2014 In present study, a series of novel tacrine-coumarin hybrids were designed, synthesized and evaluated as potent dual-site AChE inhibitors. Tacrine 36-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 25088549-3 2014 In present study, a series of novel tacrine-coumarin hybrids were designed, synthesized and evaluated as potent dual-site AChE inhibitors. coumarin 44-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 24997974-4 2014 The biosensor was prepared by incorporating acetylcholinesterase enzyme (AChE) to the graphite paste modified with tetracyanoquinodimethane (TCNQ) mediator, along with the use of a macroalgae (Cladaphropsis membranous) as a functional immobilization support. Graphite 86-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 25924313-2 2014 The biological regulator of this neurotransmitter is acetylcholinesterase (AChE), an enzyme that catalyzes the hydrolysis of ACh to choline and acetic acid. Acetylcholine 75-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 25036600-2 2014 The most potent AChE inhibitor was found to be homodimeric tacrine derivative 14a, which demonstrated an IC50 value of 2 nM; this value indicates an activity rate which is 250-times higher than that of tacrine 1 and 7500-times higher than 7-MEOTA 15, the compounds which were used as standards in the study. Tacrine 59-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 25036600-2 2014 The most potent AChE inhibitor was found to be homodimeric tacrine derivative 14a, which demonstrated an IC50 value of 2 nM; this value indicates an activity rate which is 250-times higher than that of tacrine 1 and 7500-times higher than 7-MEOTA 15, the compounds which were used as standards in the study. Tacrine 202-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 25036600-2 2014 The most potent AChE inhibitor was found to be homodimeric tacrine derivative 14a, which demonstrated an IC50 value of 2 nM; this value indicates an activity rate which is 250-times higher than that of tacrine 1 and 7500-times higher than 7-MEOTA 15, the compounds which were used as standards in the study. 7-methoxytacrine 239-246 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 25924313-6 2014 The biosensor is based on a self-assembled platform formed by poly(allylamine) hydrochloride (PAH) and silicon dioxide nanoparticles (SiO2-Np) that contains the immobilized enzyme AChE. polyallylamine 94-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 25924313-6 2014 The biosensor is based on a self-assembled platform formed by poly(allylamine) hydrochloride (PAH) and silicon dioxide nanoparticles (SiO2-Np) that contains the immobilized enzyme AChE. Silicon Dioxide 103-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 25924313-8 2014 After quantifying ACh, the inhibition of AChE in the presence of methamidophos was determined, enabling the quantification of methamidophos expressed as the percentage of enzyme inhibition. methamidophos 65-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 25924313-8 2014 After quantifying ACh, the inhibition of AChE in the presence of methamidophos was determined, enabling the quantification of methamidophos expressed as the percentage of enzyme inhibition. methamidophos 126-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 24549829-0 2014 Unbinding free energy of acetylcholinesterase bound oxime drugs along the gorge pathway from metadynamics-umbrella sampling investigation. Oximes 52-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 24865421-6 2014 RESULTS: RBC AChE activity levels at presentation and at 24 h of presentation had a negative correlation with duration of mechanical ventilation in subjects who ingested dimethyl organophosphate, but this correlation was not observed for those who had ingested diethyl or unclassified organophosphate. dimethyl organophosphate 170-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 24865421-6 2014 RESULTS: RBC AChE activity levels at presentation and at 24 h of presentation had a negative correlation with duration of mechanical ventilation in subjects who ingested dimethyl organophosphate, but this correlation was not observed for those who had ingested diethyl or unclassified organophosphate. Organophosphates 179-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 24865421-7 2014 The optimal cutoff value of RBC AChE activity at presentation for predicting mechanical ventilation for < 7 d was 1,330 U/L in subjects intoxicated with dimethyl organophosphate. dimethyl organophosphate 156-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 24865421-9 2014 CONCLUSIONS: We conclude that RBC AChE activity within 24 h of presentation can help predict the duration of mechanical ventilation for dimethyl organophosphate intoxication; however, RBC AChE activity at the time of weaning trial may not be a suitable parameter for predicting a patient"s ability to be weaned from mechanical ventilation. dimethyl organophosphate 136-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 24650611-1 2014 Given the broad spectrum of uses of acrylonitrile derivatives as fluorescent probes, AChE inhibitors, and others, it is necessary to find easy, efficient and simple methods to synthesize and diversify these compounds. Acrylonitrile 36-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 25518328-0 2014 [Design, synthesis and activity of N-acyl-thiochromenothiazol-2-amine as acetylcholinesterase inhibitors]. n-acyl-thiochromenothiazol-2-amine 35-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 25518328-1 2014 A series of novel N-acyl-thiochromenothiazol-2-amine derivatives were designed and synthesized, furthermore, their inhibition effect on acetylcholinesterase was investigated. n-acyl-thiochromenothiazol-2-amine 18-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 25141174-5 2014 Acetylcholinesterase (AChE), beta-secretase (BACE-1), and amyloid beta (Abeta) aggregation, with one member, protriptyline, showing highest inhibitory activity. Protriptyline 109-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 25141174-5 2014 Acetylcholinesterase (AChE), beta-secretase (BACE-1), and amyloid beta (Abeta) aggregation, with one member, protriptyline, showing highest inhibitory activity. Protriptyline 109-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 24872501-0 2014 Correlation of the dynamics of native human acetylcholinesterase and its inhibited huperzine A counterpart from sub-picoseconds to nanoseconds. huperzine A 83-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 24872501-2 2014 To shed light on this puzzle, the enzyme human acetylcholinesterase in its wild-type form and complexed with the inhibitor huperzine A were investigated by various neutron scattering techniques and molecular dynamics simulations. huperzine A 123-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 24652148-2 2014 Most often binding to serine, tyrosine, or threonine residues is described as being of relevance for toxicological effects (e.g., acetylcholinesterase and neuropathy target esterase) or as biomarkers for post-exposure analysis (verification, e.g., albumin and butyrylcholinesterase). Serine 22-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 24652148-2 2014 Most often binding to serine, tyrosine, or threonine residues is described as being of relevance for toxicological effects (e.g., acetylcholinesterase and neuropathy target esterase) or as biomarkers for post-exposure analysis (verification, e.g., albumin and butyrylcholinesterase). Tyrosine 30-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 24652148-2 2014 Most often binding to serine, tyrosine, or threonine residues is described as being of relevance for toxicological effects (e.g., acetylcholinesterase and neuropathy target esterase) or as biomarkers for post-exposure analysis (verification, e.g., albumin and butyrylcholinesterase). Threonine 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 24476507-3 2014 These oxon metabolites can bind and inhibit acetylcholinesterase, thus causing acute cholinergic neurotoxicity. oxon 6-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 25036795-0 2014 Indolinone-based acetylcholinesterase inhibitors: synthesis, biological activity and molecular modeling. Oxindoles 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 25036795-1 2014 A series of indolinone-based compounds bearing benzylpyridinium moiety was designed as dual-binding inhibitors of acetylcholinesterase (AChE). Oxindoles 12-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 25036795-1 2014 A series of indolinone-based compounds bearing benzylpyridinium moiety was designed as dual-binding inhibitors of acetylcholinesterase (AChE). Oxindoles 12-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 25036795-1 2014 A series of indolinone-based compounds bearing benzylpyridinium moiety was designed as dual-binding inhibitors of acetylcholinesterase (AChE). benzylpyridinium 47-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 25036795-1 2014 A series of indolinone-based compounds bearing benzylpyridinium moiety was designed as dual-binding inhibitors of acetylcholinesterase (AChE). benzylpyridinium 47-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 25036795-3 2014 The anti-cholinesterase activity evaluation of synthesized compounds revealed that most of them had very potent inhibitory activity against AChE, superior to standard drug donepezil. Donepezil 172-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 25036795-4 2014 Particularly, 2-chlorobenzyl derivative 3c was the most potent compound against AChE with IC50 value of 0.44 nM, being 32-fold more potent than donepezil. Donepezil 144-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 25036795-6 2014 Docking study revealed that the hydrophobic aromatic part (indoline) of representative compound 3c binds to the PAS and the N-benzylpyridinium residue binds to the CAS of AChE. indoline 59-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 25036795-6 2014 Docking study revealed that the hydrophobic aromatic part (indoline) of representative compound 3c binds to the PAS and the N-benzylpyridinium residue binds to the CAS of AChE. n-benzylpyridinium 124-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-175 24890706-0 2014 Design, synthesis, and evaluation of 7H-thiazolo-[3,2-b]-1,2,4-triazin-7-one derivatives as dual binding site acetylcholinesterase inhibitors. 7H-thiazolo(3,2-b)-1,2,4-triazin-7-one 37-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 24890706-2 2014 Therefore, a series of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives 6a-j were synthesized and investigated for their ability to inhibit the activity of human AChE (hAChE) in comparison with huperzine-A. 7H-thiazolo(3,2-b)-1,2,4-triazin-7-one 23-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 24890706-2 2014 Therefore, a series of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives 6a-j were synthesized and investigated for their ability to inhibit the activity of human AChE (hAChE) in comparison with huperzine-A. 7H-thiazolo(3,2-b)-1,2,4-triazin-7-one 23-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-175 24890706-2 2014 Therefore, a series of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives 6a-j were synthesized and investigated for their ability to inhibit the activity of human AChE (hAChE) in comparison with huperzine-A. -j 76-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 24890706-2 2014 Therefore, a series of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives 6a-j were synthesized and investigated for their ability to inhibit the activity of human AChE (hAChE) in comparison with huperzine-A. huperzine A 196-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-175 24611490-0 2014 A new role for the nonpathogenic nonsynonymous single-nucleotide polymorphisms of acetylcholinesterase in the treatment of Alzheimer"s disease: a computational study. single-nucleotide 47-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 24611490-8 2014 Interestingly, huperzine A alone exhibited higher efficiency in its binding to the AChE and retained similar orientation irrespective of the polymorphisms since the orientation of Asp74 involved in its binding and trafficking remained unaltered in all protein forms. huperzine A 15-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 25924313-2 2014 The biological regulator of this neurotransmitter is acetylcholinesterase (AChE), an enzyme that catalyzes the hydrolysis of ACh to choline and acetic acid. Choline 59-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 25924313-2 2014 The biological regulator of this neurotransmitter is acetylcholinesterase (AChE), an enzyme that catalyzes the hydrolysis of ACh to choline and acetic acid. Acetic Acid 144-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 25924313-2 2014 The biological regulator of this neurotransmitter is acetylcholinesterase (AChE), an enzyme that catalyzes the hydrolysis of ACh to choline and acetic acid. Acetic Acid 144-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 25924313-6 2014 The biosensor is based on a self-assembled platform formed by poly(allylamine) hydrochloride (PAH) and silicon dioxide nanoparticles (SiO2-Np) that contains the immobilized enzyme AChE. polyallylamine 62-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 24964273-0 2014 Can hydroxylamine be a more potent nucleophile for the reactivation of tabun-inhibited AChE than prototype oxime drugs? Hydroxylamine 4-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 24964273-2 2014 Organophosphorus nerve agents are highly toxic compounds which strongly inhibit acetylcholinesterase (AChE) in the blood and in the central nervous system (CNS). organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 24964273-2 2014 Organophosphorus nerve agents are highly toxic compounds which strongly inhibit acetylcholinesterase (AChE) in the blood and in the central nervous system (CNS). organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 24964273-3 2014 Tabun is one of the highly toxic organophosphorus (OP) compounds and is resistant to many oxime drugs formulated for the reactivation of AChE. Oximes 90-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 24964273-9 2014 Furthermore, we have also examined the reactivation process of tabun-inhibited AChE with some other bis-quaternary oxime drug candidates such as methoxime (MMB4) and obidoxime. Obidoxime Chloride 166-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 24964273-10 2014 The docking analysis suggests that charged bis-quaternary pyridinium oximes have greater binding affinity inside the active-site gorge of AChE compared to the neutral pyridinylhydroxylamine. bis-quaternary pyridinium oximes 43-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 24964273-10 2014 The docking analysis suggests that charged bis-quaternary pyridinium oximes have greater binding affinity inside the active-site gorge of AChE compared to the neutral pyridinylhydroxylamine. pyridinylhydroxylamine 167-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 24964273-11 2014 The peripheral ligand attached to the neutral pyridinylhydroxylamine enhanced the binding with the aromatic residues in the active-site gorge of AChE through effective pi-pi interactions. pyridinylhydroxylamine 46-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 24964273-15 2014 The toxicity measurements and the IC50 values (a measure of the intrinsic affinity toward AChE) suggest that the pyridinylhydroxylamine compound could have similar toxic behavior compared to the prototype oxime antidotes used for reactivation purposes. pyridinylhydroxylamine 113-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 24895330-5 2014 Using structure-based design, we synthesized several azobenzene analogues of the well-known AChE inhibitor tacrine (THA) and determined their effects on enzymatic activity. azobenzene 53-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 24479585-2 2014 We present here a comparison of the reorientation dynamics of individual water molecules within the hydration shell of a series of globular proteins: acetylcholinesterase, subtilisin Carlsberg, lysozyme, and ubiquitin. Water 73-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 24797332-1 2014 Rivastigmine is a non-competitive inhibitor of both acetylcholinesterase (AChE) and butylcholinesterase (BuChE) used to treat mild to moderate dementia in Alzheimer"s disease (AD) patients. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 24797332-1 2014 Rivastigmine is a non-competitive inhibitor of both acetylcholinesterase (AChE) and butylcholinesterase (BuChE) used to treat mild to moderate dementia in Alzheimer"s disease (AD) patients. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 24895330-5 2014 Using structure-based design, we synthesized several azobenzene analogues of the well-known AChE inhibitor tacrine (THA) and determined their effects on enzymatic activity. Tacrine 107-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 24895330-5 2014 Using structure-based design, we synthesized several azobenzene analogues of the well-known AChE inhibitor tacrine (THA) and determined their effects on enzymatic activity. tha 116-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 24895330-6 2014 One of our compounds, AzoTHA, is a reversible photochromic blocker of AChE in vitro and ex vivo with high affinity and fast kinetics. azotha 22-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 24785550-1 2014 INTRODUCTION: Donepezil is a highly selective acetylcholinesterase inhibitor and one of the only four drugs currently approved for treatment of Alzheimer"s dementia. Donepezil 14-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 24853320-4 2014 Drugs presently used for the treatment of AD inhibit the two ACh controlling enzymes, acetylcholinesterase as well as butyrylcholinesterase; hence, the design of selective inhibitors is called for. Acetylcholine 61-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 24853320-6 2014 Although its glycon, glycyrrhetinic acid is known for being an AChE activator, several derivatives, altered in position C-3 and C-30, exhibited remarkable inhibition constants in micro-molar range. Glycyrrhetinic Acid 21-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 24573600-0 2014 Acetylcholinesterase complexes with the natural product inhibitors dihydrotanshinone I and territrem B: binding site assignment from inhibitor competition and validation through crystal structure determination. DIHYDROTANSHINONE 67-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24909082-0 2014 Synthesis and characterization of novel 1,2-oxazine-based small molecules that targets acetylcholinesterase. 1,2-oxazine 40-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 24909082-1 2014 Thirteen 2-oxazine-based small molecules were synthesized targeting 5-lipoxygenase (LOX), and acetylcholinesterase (AChE). 5,6-Dihydro-4H-1,2-oxazine 9-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 24909082-1 2014 Thirteen 2-oxazine-based small molecules were synthesized targeting 5-lipoxygenase (LOX), and acetylcholinesterase (AChE). 5,6-Dihydro-4H-1,2-oxazine 9-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 24242952-2 2014 Insights into the physiological meaning of glycosylphosphatidylinositol (GPI)-linked AChE-H were gained by comparing nervous and non-nervous tissues for the amount of AChE mRNA variants they contained. Glycosylphosphatidylinositols 43-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 24242952-2 2014 Insights into the physiological meaning of glycosylphosphatidylinositol (GPI)-linked AChE-H were gained by comparing nervous and non-nervous tissues for the amount of AChE mRNA variants they contained. Glycosylphosphatidylinositols 43-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 24242952-2 2014 Insights into the physiological meaning of glycosylphosphatidylinositol (GPI)-linked AChE-H were gained by comparing nervous and non-nervous tissues for the amount of AChE mRNA variants they contained. Glycosylphosphatidylinositols 73-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 24242952-2 2014 Insights into the physiological meaning of glycosylphosphatidylinositol (GPI)-linked AChE-H were gained by comparing nervous and non-nervous tissues for the amount of AChE mRNA variants they contained. Glycosylphosphatidylinositols 73-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 24242952-7 2014 Thus, non-synaptic glypiated AChE-H seems to be the counterpart of synaptic PRiMA-linked AChE-T, the former designed for clearing ACh waves, the latter for confronting ACh bursts, and both for helping to protect cells against the harmful effects of durable nicotinic and muscarinic activation. Acetylcholine 29-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 24242952-7 2014 Thus, non-synaptic glypiated AChE-H seems to be the counterpart of synaptic PRiMA-linked AChE-T, the former designed for clearing ACh waves, the latter for confronting ACh bursts, and both for helping to protect cells against the harmful effects of durable nicotinic and muscarinic activation. Acetylcholine 89-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 24243026-0 2014 Dioxin and dioxin-like compounds suppress acetylcholinesterase activity via transcriptional downregulations in vitro. Dioxins 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 24573600-1 2014 Acetylcholinesterase (AChE) is a critical enzyme that regulates neurotransmission by degrading the neurotransmitter acetylcholine in synapses of the nervous system. Acetylcholine 116-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24243026-0 2014 Dioxin and dioxin-like compounds suppress acetylcholinesterase activity via transcriptional downregulations in vitro. Dioxins 11-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 24243026-3 2014 Our previous study showed that 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) suppressed neuronal AChE enzymatic activity via transcriptional downregulations mediated by aryl hydrocarbon receptor. Polychlorinated Dibenzodioxins 31-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 24573600-1 2014 Acetylcholinesterase (AChE) is a critical enzyme that regulates neurotransmission by degrading the neurotransmitter acetylcholine in synapses of the nervous system. Acetylcholine 116-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 24243026-3 2014 Our previous study showed that 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) suppressed neuronal AChE enzymatic activity via transcriptional downregulations mediated by aryl hydrocarbon receptor. Polychlorinated Dibenzodioxins 68-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 24793543-0 2014 Synergistic inhibition on acetylcholinesterase by the combination of berberine and palmatine originally isolated from Chinese medicinal herbs. Berberine 69-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 24243026-4 2014 In the present study, the effects of several other dioxin-like compounds (DLCs) on neuronal AChE activity were determined, including 1,2,3,7,8-pentachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, 2,3,4,7,8-pentachlorodibenzofuran, and 2,3,7,8-tetrabromodibenzo-p-dioxin. Dioxins 51-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 24243026-4 2014 In the present study, the effects of several other dioxin-like compounds (DLCs) on neuronal AChE activity were determined, including 1,2,3,7,8-pentachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, 2,3,4,7,8-pentachlorodibenzofuran, and 2,3,7,8-tetrabromodibenzo-p-dioxin. 2,3,4,7,8-pentachlorodibenzofuran 205-238 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 24243026-4 2014 In the present study, the effects of several other dioxin-like compounds (DLCs) on neuronal AChE activity were determined, including 1,2,3,7,8-pentachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, 2,3,4,7,8-pentachlorodibenzofuran, and 2,3,7,8-tetrabromodibenzo-p-dioxin. 2,3,7,8-tetrabromodibenzo-4-dioxin 244-278 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 24243026-7 2014 These findings on DLCs are similar with those on 2,3,7,8-TCDD, pointing to the possibility that exposure to dioxin and DLCs, which frequently coexist in the contaminated environments, may concurrently interfere with the cholinergic functions via AChE. Dioxins 108-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 246-250 24254221-2 2014 Acetylcholine, the main parasympathetic neurotransmitter and inflammation regulator, is hydrolyzed by the two closely homologous enzymes, acetylcholinesterase and butyrylcholinesterase (AChE and BChE, respectively), which are also expressed in the serum. Acetylcholine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-184 24254221-2 2014 Acetylcholine, the main parasympathetic neurotransmitter and inflammation regulator, is hydrolyzed by the two closely homologous enzymes, acetylcholinesterase and butyrylcholinesterase (AChE and BChE, respectively), which are also expressed in the serum. Acetylcholine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 24258317-0 2014 AChE and RACK1 promote the anti-inflammatory properties of fluoxetine. Fluoxetine 59-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 24258317-4 2014 Furthermore, we show that fluoxetine intercepts the LPS-induced decreases in intracellular acetylcholinesterase (AChE-S) and that AChE-S interacts with the nuclear factor kappa B (NFkappaB)-activating intracellular receptor for activated C kinase 1 (RACK1). Fluoxetine 26-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 24258317-4 2014 Furthermore, we show that fluoxetine intercepts the LPS-induced decreases in intracellular acetylcholinesterase (AChE-S) and that AChE-S interacts with the nuclear factor kappa B (NFkappaB)-activating intracellular receptor for activated C kinase 1 (RACK1). Fluoxetine 26-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-119 24318838-2 2014 Moreover, alternative functions of AChE unrelated with the hydrolysis of acetylcholine are suspected. Acetylcholine 73-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 25002771-1 2014 The victims of organophosphorus (OP) pesticide poisoning usually present with acute cholinergic crisis, due to the inhibition of the enzyme acetylcholinesterase. organophosphorus 15-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-160 24793543-0 2014 Synergistic inhibition on acetylcholinesterase by the combination of berberine and palmatine originally isolated from Chinese medicinal herbs. palmatine 83-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 24774720-0 2014 Rapid detoxification of benzodiazepine or Z-drugs dependence using acetylcholinesterase inhibitors. Benzodiazepines 24-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-87 24774720-4 2014 Acetylcholinesterase inhibitors have been shown to reverse BZDs induced sedation. Benzodiazepines 59-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24774720-5 2014 We propose that oral form acetylcholinesterase inhibitors (donepezil, galantamine and rivastigmine) also posses the effect of inhibiting GABA receptors, and act as indirect antagonist, to be applied in the rapid detoxification treatment of BZDs and Z-drug dependence. Donepezil 59-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 24793543-5 2014 Our results showed that the combination of berberine and palmatine inhibited acetylcholinesterase in a mixed competitive pattern. Berberine 43-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 24793543-5 2014 Our results showed that the combination of berberine and palmatine inhibited acetylcholinesterase in a mixed competitive pattern. palmatine 57-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 24793543-6 2014 By the median-effect principle, the calculated combination index of the combination was less than 1, suggesting that berberine and plamatine inhibited acetylcholinesterase synergistically. Berberine 117-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-171 24793543-6 2014 By the median-effect principle, the calculated combination index of the combination was less than 1, suggesting that berberine and plamatine inhibited acetylcholinesterase synergistically. plamatine 131-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-171 24774720-5 2014 We propose that oral form acetylcholinesterase inhibitors (donepezil, galantamine and rivastigmine) also posses the effect of inhibiting GABA receptors, and act as indirect antagonist, to be applied in the rapid detoxification treatment of BZDs and Z-drug dependence. Galantamine 70-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 24770670-0 2014 Acetylcholinesterase biosensor based on a gold nanoparticle-polypyrrole-reduced graphene oxide nanocomposite modified electrode for the amperometric detection of organophosphorus pesticides. polypyrrole 60-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24774720-5 2014 We propose that oral form acetylcholinesterase inhibitors (donepezil, galantamine and rivastigmine) also posses the effect of inhibiting GABA receptors, and act as indirect antagonist, to be applied in the rapid detoxification treatment of BZDs and Z-drug dependence. Rivastigmine 86-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 24774720-5 2014 We propose that oral form acetylcholinesterase inhibitors (donepezil, galantamine and rivastigmine) also posses the effect of inhibiting GABA receptors, and act as indirect antagonist, to be applied in the rapid detoxification treatment of BZDs and Z-drug dependence. Benzodiazepines 240-244 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 24866105-8 2014 To demonstrate the potential of this polymer brush functionalization scaffold, we modified solution-gated graphene field-effect transistors with the enzyme acetylcholinesterase and a transducing group, allowing the detection of the neurotransmitter acetylcholine. Polymers 37-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-176 24866105-8 2014 To demonstrate the potential of this polymer brush functionalization scaffold, we modified solution-gated graphene field-effect transistors with the enzyme acetylcholinesterase and a transducing group, allowing the detection of the neurotransmitter acetylcholine. Graphite 106-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-176 24836068-4 2014 Twelve compounds, mostly piperidino and imidazolo derivatives, inhibited AChE in low micromolar range, and were inactive toward BChE. piperidino 25-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 24836068-4 2014 Twelve compounds, mostly piperidino and imidazolo derivatives, inhibited AChE in low micromolar range, and were inactive toward BChE. imidazolo 40-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 24836068-8 2014 Thorough docking calculations of the seven most potent AChE inhibitors from the set, showed that the hydrogen bond can be formed between amide -NH- moiety of compounds and -OH group of Tyr 124. Hydrogen 101-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 24836068-8 2014 Thorough docking calculations of the seven most potent AChE inhibitors from the set, showed that the hydrogen bond can be formed between amide -NH- moiety of compounds and -OH group of Tyr 124. Amides 137-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 24836068-8 2014 Thorough docking calculations of the seven most potent AChE inhibitors from the set, showed that the hydrogen bond can be formed between amide -NH- moiety of compounds and -OH group of Tyr 124. Tyrosine 185-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 24844448-0 2014 Synthesis and biological evaluation of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives as dual binding site acetylcholinesterase inhibitors. 7H-thiazolo(3,2-b)-1,2,4-triazin-7-one 39-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 24844448-1 2014 A series of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives 7a-i were synthesized and evaluated as novel acetylcholinesterase (AChE) inhibitors. 7H-thiazolo(3,2-b)-1,2,4-triazin-7-one 12-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 24844448-1 2014 A series of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives 7a-i were synthesized and evaluated as novel acetylcholinesterase (AChE) inhibitors. 7H-thiazolo(3,2-b)-1,2,4-triazin-7-one 12-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-134 24852273-4 2014 These strategies have been applied in the present case to the AChE inhibitor galantamine with the aim of alleviating adverse effects observed with cholinergic AD treatment. Galantamine 77-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 24950437-0 2014 Xanthenedione derivatives, new promising antioxidant and acetylcholinesterase inhibitor agents. xanthenedione 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 24770670-0 2014 Acetylcholinesterase biosensor based on a gold nanoparticle-polypyrrole-reduced graphene oxide nanocomposite modified electrode for the amperometric detection of organophosphorus pesticides. reduced graphene oxide 72-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24770670-0 2014 Acetylcholinesterase biosensor based on a gold nanoparticle-polypyrrole-reduced graphene oxide nanocomposite modified electrode for the amperometric detection of organophosphorus pesticides. organophosphorus 162-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24770670-2 2014 Acetylcholinesterase (AChE) was further encapsulated in a silica matrix and immobilized on the Au-PPy-rGO nanocomposite by co-deposition with (NH4)2SiF6. Silicon Dioxide 58-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24770670-2 2014 Acetylcholinesterase (AChE) was further encapsulated in a silica matrix and immobilized on the Au-PPy-rGO nanocomposite by co-deposition with (NH4)2SiF6. Silicon Dioxide 58-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 24770670-2 2014 Acetylcholinesterase (AChE) was further encapsulated in a silica matrix and immobilized on the Au-PPy-rGO nanocomposite by co-deposition with (NH4)2SiF6. (nh4)2sif6 142-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24770670-2 2014 Acetylcholinesterase (AChE) was further encapsulated in a silica matrix and immobilized on the Au-PPy-rGO nanocomposite by co-deposition with (NH4)2SiF6. (nh4)2sif6 142-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 24770670-5 2014 Since AChE molecules were protected by the circumambient silica matrix, which provided a biocompatible environment and facilitated mass transport, the fabricated AChE biosensor displayed high stability and excellent activity together with a fast response to organophosphorus pesticides. Silicon Dioxide 57-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 24770670-5 2014 Since AChE molecules were protected by the circumambient silica matrix, which provided a biocompatible environment and facilitated mass transport, the fabricated AChE biosensor displayed high stability and excellent activity together with a fast response to organophosphorus pesticides. Silicon Dioxide 57-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-166 24770670-5 2014 Since AChE molecules were protected by the circumambient silica matrix, which provided a biocompatible environment and facilitated mass transport, the fabricated AChE biosensor displayed high stability and excellent activity together with a fast response to organophosphorus pesticides. organophosphorus 258-274 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 24770670-5 2014 Since AChE molecules were protected by the circumambient silica matrix, which provided a biocompatible environment and facilitated mass transport, the fabricated AChE biosensor displayed high stability and excellent activity together with a fast response to organophosphorus pesticides. organophosphorus 258-274 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-166 25212025-2 2014 N-Acyl-4-phenylthiazole-2-amines were prepared from substituted 2-bromo-1-acetophenones by three steps reaction, and their AChE inhibitory activities were measured by Ellman method in vitro. n-acyl-4-phenylthiazole-2-amines 0-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 24832999-2 2014 Here, we report on a versatile strategy to synthesize functionalized graphene oxide nanomaterials with abundant affinity groups that can capture histidine (His)-tagged acetylcholinesterase (AChE) for the fabrication of paraoxon biosensors. graphene oxide 69-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 190-194 24832999-2 2014 Here, we report on a versatile strategy to synthesize functionalized graphene oxide nanomaterials with abundant affinity groups that can capture histidine (His)-tagged acetylcholinesterase (AChE) for the fabrication of paraoxon biosensors. Histidine 145-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 190-194 24832999-2 2014 Here, we report on a versatile strategy to synthesize functionalized graphene oxide nanomaterials with abundant affinity groups that can capture histidine (His)-tagged acetylcholinesterase (AChE) for the fabrication of paraoxon biosensors. Histidine 156-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 190-194 24832999-2 2014 Here, we report on a versatile strategy to synthesize functionalized graphene oxide nanomaterials with abundant affinity groups that can capture histidine (His)-tagged acetylcholinesterase (AChE) for the fabrication of paraoxon biosensors. Paraoxon 219-227 acetylcholinesterase (Cartwright blood group) Homo sapiens 190-194 24832999-5 2014 AChE was immobilized on the functionalized graphene oxide (FGO) through the specific binding between Ni-NTA and His-tag. graphene oxide 43-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 24832999-5 2014 AChE was immobilized on the functionalized graphene oxide (FGO) through the specific binding between Ni-NTA and His-tag. ni-nta 101-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 24832999-5 2014 AChE was immobilized on the functionalized graphene oxide (FGO) through the specific binding between Ni-NTA and His-tag. Histidine 112-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 24628027-3 2014 Compound 11b bearing an octylene linker exhibited interactions with both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. 1-octene 24-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 24628027-3 2014 Compound 11b bearing an octylene linker exhibited interactions with both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. Aminosalicylic Acid 138-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 24628027-5 2014 The AChE-induced beta-amyloid (Abeta) aggregation assay gave further experimental support to this finding: Abeta1-40 aggregation catalyzed by the PAS of AChE might be inhibited by compound 11b in a concentration-dependent manner and seems to occur only with one photochromic form. Aminosalicylic Acid 146-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 24628027-5 2014 The AChE-induced beta-amyloid (Abeta) aggregation assay gave further experimental support to this finding: Abeta1-40 aggregation catalyzed by the PAS of AChE might be inhibited by compound 11b in a concentration-dependent manner and seems to occur only with one photochromic form. Aminosalicylic Acid 146-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 24738476-4 2014 Moreover, they displace propidium from the peripheral anionic site of AChE, preventing the beta-amyloid aggregation promoted by AChE. Propidium 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 24573600-5 2014 Here, we review our recent reports on two uncharged, natural product inhibitors of AChE, dihydrotanshinone I and territrem B, that have relatively high affinities for the enzyme. DIHYDROTANSHINONE 89-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 24731819-0 2014 An acetylcholinesterase biosensor based on graphene-gold nanocomposite and calcined layered double hydroxide. Graphite 43-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 3-23 24731819-0 2014 An acetylcholinesterase biosensor based on graphene-gold nanocomposite and calcined layered double hydroxide. layered double hydroxide 84-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 3-23 24731819-2 2014 Acetylcholinesterase (AChE) was immobilized onto a glassy carbon electrode (GCE) with the aid of Cu-Mg-Al calcined layered double hydroxide (CLDH). Carbon 58-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24731819-2 2014 Acetylcholinesterase (AChE) was immobilized onto a glassy carbon electrode (GCE) with the aid of Cu-Mg-Al calcined layered double hydroxide (CLDH). Carbon 58-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 24731819-2 2014 Acetylcholinesterase (AChE) was immobilized onto a glassy carbon electrode (GCE) with the aid of Cu-Mg-Al calcined layered double hydroxide (CLDH). cu-mg-al 97-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24731819-2 2014 Acetylcholinesterase (AChE) was immobilized onto a glassy carbon electrode (GCE) with the aid of Cu-Mg-Al calcined layered double hydroxide (CLDH). cu-mg-al 97-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 24731819-2 2014 Acetylcholinesterase (AChE) was immobilized onto a glassy carbon electrode (GCE) with the aid of Cu-Mg-Al calcined layered double hydroxide (CLDH). double hydroxide 123-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24731819-2 2014 Acetylcholinesterase (AChE) was immobilized onto a glassy carbon electrode (GCE) with the aid of Cu-Mg-Al calcined layered double hydroxide (CLDH). double hydroxide 123-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 24731819-6 2014 Thus, the graphene-gold nanocomposite (GN-AuNPs) was firstly modified onto the GCE, and then the prepared CLDH-AChE composite was immobilized onto the modified GCE to construct a sensitive AChE biosensor for pesticides detection. Graphite 10-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 24731819-6 2014 Thus, the graphene-gold nanocomposite (GN-AuNPs) was firstly modified onto the GCE, and then the prepared CLDH-AChE composite was immobilized onto the modified GCE to construct a sensitive AChE biosensor for pesticides detection. Graphite 10-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-193 24738476-4 2014 Moreover, they displace propidium from the peripheral anionic site of AChE, preventing the beta-amyloid aggregation promoted by AChE. Propidium 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 24681070-3 2014 These phenylene-connected hybrid compounds were investigated as potential inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Phenylephrine 6-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 24811076-0 2014 Acetylcholinesterase inhibition-based biosensor for aluminum(III) chronoamperometric determination in aqueous media. ALUMINUM ION 52-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24811076-1 2014 A novel amperometric biosensor for the determination of Al(III) based on the inhibition of the enzyme acetylcholinesterase has been developed. al(iii) 56-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 24704618-0 2014 Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase. tetrahydroacridine pyridine 53-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-201 24704618-0 2014 Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase. acetaldehyde oxime 82-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-201 24704618-0 2014 Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase. amidoxime 96-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-201 24704618-1 2014 A series of new uncharged functional acetylcholinesterase (AChE) reactivators including heterodimers of tetrahydroacridine with 3-hydroxy-2-pyridine aldoximes and amidoximes has been synthesized. 1,2,3,4-Tetrahydroacridine 104-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 24704618-1 2014 A series of new uncharged functional acetylcholinesterase (AChE) reactivators including heterodimers of tetrahydroacridine with 3-hydroxy-2-pyridine aldoximes and amidoximes has been synthesized. 1,2,3,4-Tetrahydroacridine 104-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 24704618-1 2014 A series of new uncharged functional acetylcholinesterase (AChE) reactivators including heterodimers of tetrahydroacridine with 3-hydroxy-2-pyridine aldoximes and amidoximes has been synthesized. 3-hydroxy-2-pyridine 128-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 24704618-1 2014 A series of new uncharged functional acetylcholinesterase (AChE) reactivators including heterodimers of tetrahydroacridine with 3-hydroxy-2-pyridine aldoximes and amidoximes has been synthesized. 3-hydroxy-2-pyridine 128-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 24704618-1 2014 A series of new uncharged functional acetylcholinesterase (AChE) reactivators including heterodimers of tetrahydroacridine with 3-hydroxy-2-pyridine aldoximes and amidoximes has been synthesized. amidoxime 163-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 24704618-1 2014 A series of new uncharged functional acetylcholinesterase (AChE) reactivators including heterodimers of tetrahydroacridine with 3-hydroxy-2-pyridine aldoximes and amidoximes has been synthesized. amidoxime 163-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 24704618-2 2014 These novel molecules display in vitro reactivation potencies towards VX-, tabun- and paraoxon-inhibited human AChE that are superior to those of the mono- and bis-pyridinium aldoximes currently used against nerve agent and pesticide poisoning. Paraoxon 86-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 24721830-0 2014 Synthesis and in vitro evaluation of bis-quaternary 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide derivatives as reactivators against sarin and VX inhibited human acetylcholinesterase (hAChE). bis-quaternary 2-(hydroxyimino)-n-(pyridin-3-yl)acetamide 37-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-187 24721830-3 2014 These compounds were evaluated in vitro for their reactivation efficacy against organophosphorus (OP) nerve agents (NAs) (sarin and VX) inhibited human erythrocyte ghost acetylcholinesterase (hAChE) and compared with the reactivation efficacy of 2-PAM and obidoxime. organophosphorus 80-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-197 24721830-5 2014 Some of the compounds have shown better reactivation efficacy than 2-PAM, and obidoxime against sarin and VX inhibited AChE. Obidoxime Chloride 78-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 23307638-5 2014 The acetylcholinesterase inhibitor galantamine (8 mg), in contrast, reversed RS into repetition enhancement, showing no relationship to subsequent recognition memory. Galantamine 35-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 24780534-0 2014 The effect of glyphosate, its metabolites and impurities on erythrocyte acetylcholinesterase activity. glyphosate 14-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 24780534-4 2014 That is why, we have investigated the effect of the most commonly used pesticide: glyphosate, its metabolites and impurities on acetylcholinesterase (AChE) activity (in vitro) in human erythrocytes, which is biochemically similar to acetylcholinesterase present in neural synapses. glyphosate 82-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 24780534-4 2014 That is why, we have investigated the effect of the most commonly used pesticide: glyphosate, its metabolites and impurities on acetylcholinesterase (AChE) activity (in vitro) in human erythrocytes, which is biochemically similar to acetylcholinesterase present in neural synapses. glyphosate 82-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 24281389-2 2014 The attachment of AChE to the BL is primarily accomplished by the binding of the ColQ collagen domain to the heparan sulfate proteoglycan perlecan and the COOH-terminus to the muscle-specific receptor tyrosine kinase (MuSK), which in turn plays a fundamental role in the development and maintenance of the NMJ. Heparitin Sulfate 109-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 24604285-5 2014 The alpha-anomers were the most active compounds, while selectivity for BChE or acetylcholinesterase (AChE) inhibition could be tuned by the purine base, by the glycosyl moiety and by N(7)-ligation. purine 141-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 24604285-5 2014 The alpha-anomers were the most active compounds, while selectivity for BChE or acetylcholinesterase (AChE) inhibition could be tuned by the purine base, by the glycosyl moiety and by N(7)-ligation. purine 141-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 24604285-6 2014 Some of the nucleosides were far more potent than the drug galantamine, and the most promising competitive and selective BChE inhibitor, the N(7)-linked 2-acetamido-alpha-D-mannosylpurine, showed a Ki of 50 nM and a selectivity factor of 340 fold for BChE over AChE. Nucleosides 12-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 261-265 24604285-6 2014 Some of the nucleosides were far more potent than the drug galantamine, and the most promising competitive and selective BChE inhibitor, the N(7)-linked 2-acetamido-alpha-D-mannosylpurine, showed a Ki of 50 nM and a selectivity factor of 340 fold for BChE over AChE. n(7)-linked 2-acetamido-alpha-d-mannosylpurine 141-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 261-265 24599312-3 2014 Moreover, these oximes also exhibit a good ability to reactivate VX-, tabun- and paraoxon-inhibited human AChE. Oximes 16-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 24599312-3 2014 Moreover, these oximes also exhibit a good ability to reactivate VX-, tabun- and paraoxon-inhibited human AChE. Paraoxon 81-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 24595354-2 2014 The primary enzymes responsible for the metabolism of 6-MAM to the less potent morphine in humans are acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). 6-O-monoacetylmorphine 54-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 24595354-2 2014 The primary enzymes responsible for the metabolism of 6-MAM to the less potent morphine in humans are acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). 6-O-monoacetylmorphine 54-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 24595354-2 2014 The primary enzymes responsible for the metabolism of 6-MAM to the less potent morphine in humans are acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Morphine 79-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 24595354-2 2014 The primary enzymes responsible for the metabolism of 6-MAM to the less potent morphine in humans are acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Morphine 79-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 24594525-2 2014 In vitro tests revealed that compounds 3 and 5, which bear a nitrate moiety in the molecule, showed a potent inhibition activity towards AChE and compound 3 showed a good Abeta42 aggregation inhibitory activity. Nitrates 61-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 24239594-0 2014 Preliminary findings of the effects of rivastigmine, an acetylcholinesterase inhibitor, on working memory in cocaine-dependent volunteers. Rivastigmine 39-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 24594354-1 2014 Novel mono and bis spiropyrrolidine derivatives were synthesized via an efficient ionic liquid mediated, 1,3-dipolar cycloaddition methodology and evaluated in vitro for their AChE and BChE inhibitory activities in search for potent cholinesterase enzyme inhibitors. mono and bis spiropyrrolidine 6-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 24630558-1 2014 The goal of this research was to identify structurally novel, non-quaternarypyridinium reactivators of GF (cyclosarin)-inhibited hAChE that possess the capacity to mediate in vitro reactivation of GF-inhibited human acetylcholinesterase (hAChE). quaternarypyridinium 66-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-134 24630558-1 2014 The goal of this research was to identify structurally novel, non-quaternarypyridinium reactivators of GF (cyclosarin)-inhibited hAChE that possess the capacity to mediate in vitro reactivation of GF-inhibited human acetylcholinesterase (hAChE). quaternarypyridinium 66-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 238-243 24630558-1 2014 The goal of this research was to identify structurally novel, non-quaternarypyridinium reactivators of GF (cyclosarin)-inhibited hAChE that possess the capacity to mediate in vitro reactivation of GF-inhibited human acetylcholinesterase (hAChE). glycylphenylalanine 103-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-134 24630558-1 2014 The goal of this research was to identify structurally novel, non-quaternarypyridinium reactivators of GF (cyclosarin)-inhibited hAChE that possess the capacity to mediate in vitro reactivation of GF-inhibited human acetylcholinesterase (hAChE). glycylphenylalanine 103-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 238-243 24630558-1 2014 The goal of this research was to identify structurally novel, non-quaternarypyridinium reactivators of GF (cyclosarin)-inhibited hAChE that possess the capacity to mediate in vitro reactivation of GF-inhibited human acetylcholinesterase (hAChE). cyclohexyl methylphosphonofluoridate 107-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-134 24630558-1 2014 The goal of this research was to identify structurally novel, non-quaternarypyridinium reactivators of GF (cyclosarin)-inhibited hAChE that possess the capacity to mediate in vitro reactivation of GF-inhibited human acetylcholinesterase (hAChE). cyclohexyl methylphosphonofluoridate 107-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 238-243 24630558-4 2014 Lead compounds from two different chemical series, represented by compounds 17 and 38, displayed proficient in vitro reactivation of GF-inhibited hAChE, while also possessing low inhibition of native enzyme. glycylphenylalanine 133-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-151 24504487-4 2014 Nocturnal visual hallucinations persisted in spite of reduced dopaminergic medication and sequential treatment with atypical antipsychotic medication (quetiapine and clozapine) in combination with an acetylcholinesterase inhibitor (rivastigmine). Rivastigmine 232-244 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-220 24606395-0 2014 Alkaloids from the roots of Stichoneuron caudatum and their acetylcholinesterase inhibitory activities. Alkaloids 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 24595354-3 2014 The detailed reaction pathways for AChE- and BChE-catalyzed hydrolysis of 6-MAM to morphine have been explored, for the first time, in the present study by performing first-principles quantum mechanical/molecular mechanical free energy calculations. 6-O-monoacetylmorphine 74-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-40 24681070-3 2014 These phenylene-connected hybrid compounds were investigated as potential inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Phenylephrine 6-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 24681980-1 2014 In an effort to develop multipotent agents against beta-secretase (BACE-1) and acetylcholinesterase (AChE), able to counteract intracellular ROS formation as well, the structure of the fluorinated benzophenone 3 served as starting point for the synthesis of a small library of 3-fluoro-4-hydroxy- analogues. ros 141-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 24595354-3 2014 The detailed reaction pathways for AChE- and BChE-catalyzed hydrolysis of 6-MAM to morphine have been explored, for the first time, in the present study by performing first-principles quantum mechanical/molecular mechanical free energy calculations. Morphine 83-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-40 24681980-1 2014 In an effort to develop multipotent agents against beta-secretase (BACE-1) and acetylcholinesterase (AChE), able to counteract intracellular ROS formation as well, the structure of the fluorinated benzophenone 3 served as starting point for the synthesis of a small library of 3-fluoro-4-hydroxy- analogues. ros 141-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 24681980-1 2014 In an effort to develop multipotent agents against beta-secretase (BACE-1) and acetylcholinesterase (AChE), able to counteract intracellular ROS formation as well, the structure of the fluorinated benzophenone 3 served as starting point for the synthesis of a small library of 3-fluoro-4-hydroxy- analogues. benzophenone 197-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 24681980-1 2014 In an effort to develop multipotent agents against beta-secretase (BACE-1) and acetylcholinesterase (AChE), able to counteract intracellular ROS formation as well, the structure of the fluorinated benzophenone 3 served as starting point for the synthesis of a small library of 3-fluoro-4-hydroxy- analogues. benzophenone 197-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 24059296-2 2014 AChE is a serine protease, which hydrolyses the neurotransmitter, acetylcholine into acetate and choline thereby terminating neurotransmission. Acetylcholine 66-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 24166183-8 2014 Notably, LDL cholesterol increased in a dose-dependent manner the activity of AChE in SH-SY5Y cells. Cholesterol 13-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 24556150-0 2014 Ruthenium(II) polypyridyl complex as inhibitor of acetylcholinesterase and Abeta aggregation. ruthenium(ii) polypyridyl complex 0-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 24422467-0 2014 Synthesis, biological evaluation, and computational studies of Tri- and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and hH3 receptor antagonists. Nitrogen 84-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 24422467-2 2014 However, whereas AChE inhibitors prevent hydrolysis of acetylcholine also peripherally, histamine H3 antagonists will raise acetylcholine levels mostly in the brain due to predominant occurrence of the receptor in the central nervous system. Acetylcholine 55-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-21 24422467-3 2014 In this work, we designed and synthesized two novel classes of tri- and tetracyclic nitrogen-bridgehead compounds acting as dual AChE inhibitors and histamine H3 antagonists by combining the nitrogen-bridgehead moiety of novel AChE inhibitors with a second N-basic fragment based on the piperidinylpropoxy pharmacophore with different spacer lengths. Nitrogen 84-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 24422467-3 2014 In this work, we designed and synthesized two novel classes of tri- and tetracyclic nitrogen-bridgehead compounds acting as dual AChE inhibitors and histamine H3 antagonists by combining the nitrogen-bridgehead moiety of novel AChE inhibitors with a second N-basic fragment based on the piperidinylpropoxy pharmacophore with different spacer lengths. Nitrogen 84-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 227-231 24422467-3 2014 In this work, we designed and synthesized two novel classes of tri- and tetracyclic nitrogen-bridgehead compounds acting as dual AChE inhibitors and histamine H3 antagonists by combining the nitrogen-bridgehead moiety of novel AChE inhibitors with a second N-basic fragment based on the piperidinylpropoxy pharmacophore with different spacer lengths. Histamine 149-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 227-231 24422467-3 2014 In this work, we designed and synthesized two novel classes of tri- and tetracyclic nitrogen-bridgehead compounds acting as dual AChE inhibitors and histamine H3 antagonists by combining the nitrogen-bridgehead moiety of novel AChE inhibitors with a second N-basic fragment based on the piperidinylpropoxy pharmacophore with different spacer lengths. Nitrogen 191-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-133 24422467-3 2014 In this work, we designed and synthesized two novel classes of tri- and tetracyclic nitrogen-bridgehead compounds acting as dual AChE inhibitors and histamine H3 antagonists by combining the nitrogen-bridgehead moiety of novel AChE inhibitors with a second N-basic fragment based on the piperidinylpropoxy pharmacophore with different spacer lengths. Nitrogen 191-199 acetylcholinesterase (Cartwright blood group) Homo sapiens 227-231 24447378-1 2014 Organophosphorus (OP) pesticides are a diverse class of acetylcholinesterase (AChE) inhibitors that are responsible for tremendous morbidity and mortality worldwide, killing approximately 300,000 people annually. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 24447378-1 2014 Organophosphorus (OP) pesticides are a diverse class of acetylcholinesterase (AChE) inhibitors that are responsible for tremendous morbidity and mortality worldwide, killing approximately 300,000 people annually. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 24643289-4 2014 The catalytic efficiency of E30-6 for cocaine hydrolysis is comparable to that of the most efficient known naturally occurring hydrolytic enzyme, acetylcholinesterase, the catalytic activity of which approaches the diffusion limit. Cocaine 38-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-166 24184599-1 2014 A new, highly sensitive and selective ECL assay biosensor based on target induced signal on has been developed for the detection of organophosphate pesticides (OPs), whereby the smart integration of graphene nanosheets (GNs), CdTe quantum dots (CdTe QDs), and acetylcholinesterase (AChE) enzymatic reaction yields a biofunctional AChE-GNs-QDs hybrid as cathodic ECL emitters for OPs sensing. Organophosphates 132-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 260-280 24184599-1 2014 A new, highly sensitive and selective ECL assay biosensor based on target induced signal on has been developed for the detection of organophosphate pesticides (OPs), whereby the smart integration of graphene nanosheets (GNs), CdTe quantum dots (CdTe QDs), and acetylcholinesterase (AChE) enzymatic reaction yields a biofunctional AChE-GNs-QDs hybrid as cathodic ECL emitters for OPs sensing. Organophosphates 132-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 282-286 24184599-1 2014 A new, highly sensitive and selective ECL assay biosensor based on target induced signal on has been developed for the detection of organophosphate pesticides (OPs), whereby the smart integration of graphene nanosheets (GNs), CdTe quantum dots (CdTe QDs), and acetylcholinesterase (AChE) enzymatic reaction yields a biofunctional AChE-GNs-QDs hybrid as cathodic ECL emitters for OPs sensing. Organophosphates 132-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 330-334 24184599-3 2014 On the basis of the effect of OPs on the ECL signal of AChE-QDs-GNs modified glassy carbon electrode (GCE), a highly sensitive GNs-anchored-QDs-based signal-on ECL biosensor was developed for sensing OPs, combined with the enzymatic reactions and the dissolved oxygen as coreactant. Carbon 84-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 24184599-3 2014 On the basis of the effect of OPs on the ECL signal of AChE-QDs-GNs modified glassy carbon electrode (GCE), a highly sensitive GNs-anchored-QDs-based signal-on ECL biosensor was developed for sensing OPs, combined with the enzymatic reactions and the dissolved oxygen as coreactant. Oxygen 261-267 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 24416761-2 2014 Due to the inherent biocompatibility of the Cd0.5Zn0.5S-rGO nanocomposite, acetylcholinesterase (AChE) immobilized on the Cd0.5Zn0.5S-rGO modified electrode can hydrolyze acetylthiocholine chloride into thiocholine, which could increase the photocurrent of the enzyme electrode, and the further inhibition of OPs on the enzyme electrode could decrease the photocurrent response. cd0.5zn0.5s 44-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 24416761-2 2014 Due to the inherent biocompatibility of the Cd0.5Zn0.5S-rGO nanocomposite, acetylcholinesterase (AChE) immobilized on the Cd0.5Zn0.5S-rGO modified electrode can hydrolyze acetylthiocholine chloride into thiocholine, which could increase the photocurrent of the enzyme electrode, and the further inhibition of OPs on the enzyme electrode could decrease the photocurrent response. cd0.5zn0.5s 44-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 24416761-2 2014 Due to the inherent biocompatibility of the Cd0.5Zn0.5S-rGO nanocomposite, acetylcholinesterase (AChE) immobilized on the Cd0.5Zn0.5S-rGO modified electrode can hydrolyze acetylthiocholine chloride into thiocholine, which could increase the photocurrent of the enzyme electrode, and the further inhibition of OPs on the enzyme electrode could decrease the photocurrent response. (+)-Cannabidiol 44-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 24416761-2 2014 Due to the inherent biocompatibility of the Cd0.5Zn0.5S-rGO nanocomposite, acetylcholinesterase (AChE) immobilized on the Cd0.5Zn0.5S-rGO modified electrode can hydrolyze acetylthiocholine chloride into thiocholine, which could increase the photocurrent of the enzyme electrode, and the further inhibition of OPs on the enzyme electrode could decrease the photocurrent response. (+)-Cannabidiol 44-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 24416761-2 2014 Due to the inherent biocompatibility of the Cd0.5Zn0.5S-rGO nanocomposite, acetylcholinesterase (AChE) immobilized on the Cd0.5Zn0.5S-rGO modified electrode can hydrolyze acetylthiocholine chloride into thiocholine, which could increase the photocurrent of the enzyme electrode, and the further inhibition of OPs on the enzyme electrode could decrease the photocurrent response. Acetylthiocholine chloride 171-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 24416761-2 2014 Due to the inherent biocompatibility of the Cd0.5Zn0.5S-rGO nanocomposite, acetylcholinesterase (AChE) immobilized on the Cd0.5Zn0.5S-rGO modified electrode can hydrolyze acetylthiocholine chloride into thiocholine, which could increase the photocurrent of the enzyme electrode, and the further inhibition of OPs on the enzyme electrode could decrease the photocurrent response. Thiocholine 177-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-95 24594013-5 2014 Moreover, when expressed in human embryonic kidney 293 cells, N-glycosylated AChE co-immunoprecipitated with non-O-glycosylated neurexin-1beta, with N-glycosylation of the AChE being required for this co-precipitation to occur. Nitrogen 62-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 24594013-5 2014 Moreover, when expressed in human embryonic kidney 293 cells, N-glycosylated AChE co-immunoprecipitated with non-O-glycosylated neurexin-1beta, with N-glycosylation of the AChE being required for this co-precipitation to occur. Nitrogen 62-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-176 24594013-5 2014 Moreover, when expressed in human embryonic kidney 293 cells, N-glycosylated AChE co-immunoprecipitated with non-O-glycosylated neurexin-1beta, with N-glycosylation of the AChE being required for this co-precipitation to occur. Nitrogen 149-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 24589276-1 2014 BACKGROUND: Toxicology and Emergency medicine textbooks recommend measurement of acetylcholinesterase (AChE) in all symptomatic cases of organophosphorus (OP) poisoning but laboratory facilities are limited in rural Asia. organophosphorus 137-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 24589276-1 2014 BACKGROUND: Toxicology and Emergency medicine textbooks recommend measurement of acetylcholinesterase (AChE) in all symptomatic cases of organophosphorus (OP) poisoning but laboratory facilities are limited in rural Asia. organophosphorus 137-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 23601990-1 2014 A series of phosphorylated flavonoids were synthesized and investigated in vitro as inhibitors of pancreatic cholesterol esterase (CEase) and acetylcholinesterase (AChE). Flavonoids 27-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 23601990-1 2014 A series of phosphorylated flavonoids were synthesized and investigated in vitro as inhibitors of pancreatic cholesterol esterase (CEase) and acetylcholinesterase (AChE). Flavonoids 27-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 23601990-3 2014 Furthermore, these phosphorylated flavonoids demonstrated good to high selectivity for CEase over AChE, which only showed micromolar potency inhibition of AChE. Flavonoids 34-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 23601990-3 2014 Furthermore, these phosphorylated flavonoids demonstrated good to high selectivity for CEase over AChE, which only showed micromolar potency inhibition of AChE. Flavonoids 34-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 24059299-3 2014 Hydrophobic interactions and hydrogen bonds both play an equally important role in the correct positioning of Huperzine-B within the "catalytic site" of AChE to permit docking. Hydrogen 29-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 24059299-3 2014 Hydrophobic interactions and hydrogen bonds both play an equally important role in the correct positioning of Huperzine-B within the "catalytic site" of AChE to permit docking. huperzine A 110-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 24059299-5 2014 Such information may aid in the design of versatile AChE-inhibitors, and is expected to aid in safe clinical use of Huperzine-B. huperzine A 116-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 24059299-6 2014 Scope still remains in the determination of the three-dimensional structure of AChE-Huperzine-B complex by X-ray crystallography to validate the described data. huperzine A 84-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 24059299-7 2014 Furthermore, this study confirms that Huperzine-B is a more efficient inhibitor of human brain AChE compared to tolserine with reference to Ki and DeltaG values. huperzine B 38-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 24059300-3 2014 It was found that hydrophobic interactions play an important role in the correct positioning of BNC within the "catalytic site" of AChE, BuChE and 5-LPO to permit docking while hydrogen bonds are significant in case of cymserine for the same. Hydrogen 177-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 24059300-4 2014 However, only polar interactions are significant in the correct positioning of GAL within the "catalytic site" of AChE, BuChE and 5-LPO to permit docking. galangin 79-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 24059300-7 2014 Moreover, the present study confirms that GAL is a more efficient inhibitor of human brain AChE compared to BNC and cymserine, while in case of 5-LPO and human brain BuChE, BNC is a more efficient inhibitor compared to GAL and cymserine with reference to DeltaG and Ki values. galangin 42-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 24059302-0 2014 Invokana (Canagliflozin) as a dual inhibitor of acetylcholinesterase and sodium glucose co-transporter 2: advancement in Alzheimer"s disease- diabetes type 2 linkage via an enzoinformatics study. Canagliflozin 10-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 24059302-2 2014 The present study emphasizes the molecular interactions between a new Food and Drug Administration (FDA) approved antidiabetic drug "Invokana" (chemically known as Canagliflozin) with AChE and SGLT2 to establish a link between the treatment of T2DM and Alzheimer"s Disease (AD). Canagliflozin 164-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-188 24059302-4 2014 Both hydrophobic and pi-pi interactions play an important role in the correct positioning of Canagliflozin within SGLT2 and catalytic site (CAS) of AChE to permit docking. Canagliflozin 93-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 24059302-5 2014 Free energy of binding (DeltaG) for "Canagliflozin-SGLT2" interaction and "Canagliflozin - CAS domain of AChE" interaction were found to be -10.03 kcal/mol and -9.40 kcal/mol, respectively. Canagliflozin 75-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 24059302-8 2014 However, "Canagliflozin-CAS domain of AChE" interaction revealed that out of the three amino acids constituting the catalytic triad (S203, H447 and E334), two amino acid residues (S203 and H447) interact with Canagliflozin. Canagliflozin 10-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 24059302-8 2014 However, "Canagliflozin-CAS domain of AChE" interaction revealed that out of the three amino acids constituting the catalytic triad (S203, H447 and E334), two amino acid residues (S203 and H447) interact with Canagliflozin. Canagliflozin 209-222 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 24059302-9 2014 Hence, Invokana (Canagliflozin) might act as a potent dual inhibitor of AChE and SGLT2. Canagliflozin 17-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 24059302-10 2014 However, scope still remains in the determination of the three-dimensional structure of SGLT2-Canagliflozin and AChE-Canagliflozin complexes by X-ray crystallography to validate the described data. Canagliflozin 117-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 24059296-2 2014 AChE is a serine protease, which hydrolyses the neurotransmitter, acetylcholine into acetate and choline thereby terminating neurotransmission. Acetates 85-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 24059296-2 2014 AChE is a serine protease, which hydrolyses the neurotransmitter, acetylcholine into acetate and choline thereby terminating neurotransmission. Choline 72-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 24059299-0 2014 Molecular interaction of human brain acetylcholinesterase with a natural inhibitor huperzine-B: an enzoinformatics approach. huperzine B 83-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 24059299-1 2014 The present study emphasizes the molecular interactions between human brain acetylcholinesterase (AChE) and the natural ligand Huperzine-B and its comparison to "AChE-Tolserine interactions". huperzine A 127-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 24059299-1 2014 The present study emphasizes the molecular interactions between human brain acetylcholinesterase (AChE) and the natural ligand Huperzine-B and its comparison to "AChE-Tolserine interactions". huperzine A 127-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 24059317-0 2014 A neuroinformatics study describing molecular interaction of Cisplatin with acetylcholinesterase: a plausible cause for anticancer drug induced neurotoxicity. Cisplatin 61-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 24556150-5 2014 This is the first demonstration that ruthenium(II) polypyridyl complexes simultaneously inhibit AChE and Abeta aggregation. ruthenium(ii) polypyridyl complexes 37-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 24258240-0 2014 Oxime-type acetylcholinesterase reactivators in pregnancy: an overview. Oximes 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 24258240-1 2014 Oxime-type acetylcholinesterase reactivators (oxime-AChER) are used as an adjunct in the treatment for organophosphorus anticholinesterase poisoning. oxime-acher 46-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 24059317-3 2014 This study describes molecular interactions between human brain acetylcholinesterase (AChE) and the well-known anti-neoplastic drug, Cisplatin. Cisplatin 133-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 24059317-3 2014 This study describes molecular interactions between human brain acetylcholinesterase (AChE) and the well-known anti-neoplastic drug, Cisplatin. Cisplatin 133-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 24059317-4 2014 Docking between Cisplatin and AChE was performed using "GOLD 5.0" and accessible surface area of protein before and after ligand binding was calculated by NACCESS version 2.1.1. Cisplatin 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 24059317-5 2014 Hydrophobic interactions and hydrogen bonds both play an equally important role in the correct positioning of Cisplatin within the "acyl pocket" as well as "catalytic site" of AChE to permit docking. Hydrogen 29-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 24059317-6 2014 Gold fitness score of "Cisplatin- acyl domain of AChE" interaction and "Cisplatin-CAS domain of AChE" interaction were 38.78 and 39.91, respectively and free binding energy was found to be -5.82 Kcal/mol and -5.79 Kcal/mol, respectively. Cisplatin 23-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 24059317-6 2014 Gold fitness score of "Cisplatin- acyl domain of AChE" interaction and "Cisplatin-CAS domain of AChE" interaction were 38.78 and 39.91, respectively and free binding energy was found to be -5.82 Kcal/mol and -5.79 Kcal/mol, respectively. Cisplatin 72-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 24059317-7 2014 During "Cisplatin-CAS site of AChE enzyme" interaction, it was found that out of the three amino acids constituting the catalytic triad (S203, H447 and E334), two amino acid residues namely S203 and H447 interact with Cisplatin by hydrogen bonding and hydrophobic interaction, respectively. Cisplatin 8-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 24059317-7 2014 During "Cisplatin-CAS site of AChE enzyme" interaction, it was found that out of the three amino acids constituting the catalytic triad (S203, H447 and E334), two amino acid residues namely S203 and H447 interact with Cisplatin by hydrogen bonding and hydrophobic interaction, respectively. Calcium 18-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 24059317-7 2014 During "Cisplatin-CAS site of AChE enzyme" interaction, it was found that out of the three amino acids constituting the catalytic triad (S203, H447 and E334), two amino acid residues namely S203 and H447 interact with Cisplatin by hydrogen bonding and hydrophobic interaction, respectively. Cisplatin 218-227 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 24059317-7 2014 During "Cisplatin-CAS site of AChE enzyme" interaction, it was found that out of the three amino acids constituting the catalytic triad (S203, H447 and E334), two amino acid residues namely S203 and H447 interact with Cisplatin by hydrogen bonding and hydrophobic interaction, respectively. Hydrogen 231-239 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 24059317-9 2014 Hence, Cisplatin might act as a potent inhibitor of AChE. Cisplatin 7-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 24059317-10 2014 Scope still remains in the determination of the three-dimensional structure of AChE-Cisplatin complex by X-ray crystallography to validate the described data. Cisplatin 84-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 24059317-11 2014 Moreover, such information may aid in the design of versatile AChE-inhibitors, and is expected to aid in safe clinical use of Cisplatin. Cisplatin 126-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 24635520-2 2014 In this study we synthesized and evaluated a new series of compounds, with benzo[f]coumarin structure, as potential inhibitors of MAO-A, MAO-B, AChE and BuChE. benzo[f]coumarin 75-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 24719609-3 2014 We have designed and synthesized a series of novel indole derivatives and screened them for inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). indole 51-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 24719609-3 2014 We have designed and synthesized a series of novel indole derivatives and screened them for inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). indole 51-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 24577912-1 2014 The present study deals with the erythrocytic acetylcholinesterase inhibitory activity of paracetamol and chloroquine in an in vitro protocol using Michaelis Menten parameters (Apparent Michaelis Constant (aKm) and Apparent Maximum Velocity (aVm). Acetaminophen 90-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 24577912-1 2014 The present study deals with the erythrocytic acetylcholinesterase inhibitory activity of paracetamol and chloroquine in an in vitro protocol using Michaelis Menten parameters (Apparent Michaelis Constant (aKm) and Apparent Maximum Velocity (aVm). Chloroquine 106-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 24577912-2 2014 Paracetamol showed marked inhibition of the erythrocytic acetylcholinesterase. Acetaminophen 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 24577912-5 2014 In conclusion, the cholinergic intervention by paracetamol in this study suggested a new mechanism for its analgesic activity as acetylcholinesterase inhibitors have already shown both peripheral and central analgesic activity, while the cholinergic activation by chloroquine provided explanation for some of its side effects. Acetaminophen 47-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-149 24547899-0 2014 Isolation and synthesis of pulmonarins A and B, acetylcholinesterase inhibitors from the colonial ascidian Synoicum pulmonaria. pulmonarins 27-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 24547899-3 2014 Both pulmonarins A and B displayed reversible, noncompetitive acetylcholinesterase inhibition comparable to several known natural acetylcholinesterase inhibitiors. pulmonarins 5-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 24547899-3 2014 Both pulmonarins A and B displayed reversible, noncompetitive acetylcholinesterase inhibition comparable to several known natural acetylcholinesterase inhibitiors. pulmonarins 5-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 24475784-1 2014 Many previous works have demonstrated that acetylcholinesterase (AChE) was enantioselectively inhibited by chiral organophosphorus insecticides (OPs) and that a significant difference in reactivation existed for AChE inactivated by (1R)- versus (1S,3S)-stereoisomers of isomalathion. Caffeine 245-251 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 24345352-0 2014 Interactions between xylene-linked carbamoyl bis-pyridinium mono-oximes and organophosphates inhibited-AChE: a kinetic study. Xylenes 21-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 24345352-0 2014 Interactions between xylene-linked carbamoyl bis-pyridinium mono-oximes and organophosphates inhibited-AChE: a kinetic study. carbamoyl bis-pyridinium mono-oximes 35-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 24345352-0 2014 Interactions between xylene-linked carbamoyl bis-pyridinium mono-oximes and organophosphates inhibited-AChE: a kinetic study. Organophosphates 76-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 24345352-1 2014 Reactivation of organophosphate (OP) inhibited acetylcholinesterase (AChE) by oximes is inadequate against various OP nerve agents known till date owing to their diverse structural features. Organophosphates 16-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 24345352-1 2014 Reactivation of organophosphate (OP) inhibited acetylcholinesterase (AChE) by oximes is inadequate against various OP nerve agents known till date owing to their diverse structural features. Oximes 78-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 24345352-3 2014 The efficacy of oxime reactivators is estimated through different in vitro and in vivo models using AChE from various sources against structurally different OPs. Oximes 16-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 24345352-4 2014 In the present study, reactivation kinetics of OP (paraoxon, DFP, sarin and VX) inhibited AChE by xylene linked carbamoyl bis-pyridinum mono-oximes have been described. Xylenes 98-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 24345352-4 2014 In the present study, reactivation kinetics of OP (paraoxon, DFP, sarin and VX) inhibited AChE by xylene linked carbamoyl bis-pyridinum mono-oximes have been described. carbamoyl bis-pyridinum mono-oximes 112-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 24345352-7 2014 The enhanced reactivation efficacy of oximes may be attributed to the optimal length of xylene linker which facilitates appropriate positioning of carbamoyl function to the peripheral anionic site (PAS) and extending the oxime moiety to the active site of AChE. Oximes 38-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 256-260 24345352-7 2014 The enhanced reactivation efficacy of oximes may be attributed to the optimal length of xylene linker which facilitates appropriate positioning of carbamoyl function to the peripheral anionic site (PAS) and extending the oxime moiety to the active site of AChE. Xylenes 88-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 256-260 24345352-7 2014 The enhanced reactivation efficacy of oximes may be attributed to the optimal length of xylene linker which facilitates appropriate positioning of carbamoyl function to the peripheral anionic site (PAS) and extending the oxime moiety to the active site of AChE. Oximes 38-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 256-260 24321698-12 2014 In fact, the complex formed between ChEs and the best N-aryl compound reproduced the binding mode experimentally reported, where the ligand was coupled into the choline-binding site and stabilized through pi-pi interactions with Trp82 or Trp86 for BChE and AChE, respectively, suggesting that this compound could be an efficient inhibitor and supporting our model. 2-(N-cyclohexylamino)ethanesulfonic acid 36-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 257-261 24321698-12 2014 In fact, the complex formed between ChEs and the best N-aryl compound reproduced the binding mode experimentally reported, where the ligand was coupled into the choline-binding site and stabilized through pi-pi interactions with Trp82 or Trp86 for BChE and AChE, respectively, suggesting that this compound could be an efficient inhibitor and supporting our model. Choline 161-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 257-261 24475784-1 2014 Many previous works have demonstrated that acetylcholinesterase (AChE) was enantioselectively inhibited by chiral organophosphorus insecticides (OPs) and that a significant difference in reactivation existed for AChE inactivated by (1R)- versus (1S,3S)-stereoisomers of isomalathion. organophosphorus 114-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 24475784-1 2014 Many previous works have demonstrated that acetylcholinesterase (AChE) was enantioselectively inhibited by chiral organophosphorus insecticides (OPs) and that a significant difference in reactivation existed for AChE inactivated by (1R)- versus (1S,3S)-stereoisomers of isomalathion. organophosphorus 114-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 24475784-1 2014 Many previous works have demonstrated that acetylcholinesterase (AChE) was enantioselectively inhibited by chiral organophosphorus insecticides (OPs) and that a significant difference in reactivation existed for AChE inactivated by (1R)- versus (1S,3S)-stereoisomers of isomalathion. organophosphorus 114-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 212-216 24475784-1 2014 Many previous works have demonstrated that acetylcholinesterase (AChE) was enantioselectively inhibited by chiral organophosphorus insecticides (OPs) and that a significant difference in reactivation existed for AChE inactivated by (1R)- versus (1S,3S)-stereoisomers of isomalathion. (1r) 232-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 24475784-1 2014 Many previous works have demonstrated that acetylcholinesterase (AChE) was enantioselectively inhibited by chiral organophosphorus insecticides (OPs) and that a significant difference in reactivation existed for AChE inactivated by (1R)- versus (1S,3S)-stereoisomers of isomalathion. (1r) 232-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-69 24475784-1 2014 Many previous works have demonstrated that acetylcholinesterase (AChE) was enantioselectively inhibited by chiral organophosphorus insecticides (OPs) and that a significant difference in reactivation existed for AChE inactivated by (1R)- versus (1S,3S)-stereoisomers of isomalathion. (1r) 232-236 acetylcholinesterase (Cartwright blood group) Homo sapiens 212-216 24475784-1 2014 Many previous works have demonstrated that acetylcholinesterase (AChE) was enantioselectively inhibited by chiral organophosphorus insecticides (OPs) and that a significant difference in reactivation existed for AChE inactivated by (1R)- versus (1S,3S)-stereoisomers of isomalathion. Caffeine 245-251 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 24041663-0 2014 Amperometric biosensing of organophosphate and organocarbamate pesticides utilizing polypyrrole entrapped acetylcholinesterase electrode. Organophosphates 27-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 24041663-0 2014 Amperometric biosensing of organophosphate and organocarbamate pesticides utilizing polypyrrole entrapped acetylcholinesterase electrode. organocarbamate 47-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 24041663-1 2014 The work presented here describes a novel, easy and low-cost method of fabrication of a highly sensitive acetylcholinesterase biosensor and its application to detect organophosphate and organocarbamate pesticides. Organophosphates 166-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-125 24041663-2 2014 Acetylcholinesterase was electro-immobilized into a thick conducting layer of polypyrrole. polypyrrole 78-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24389509-0 2014 1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies. 1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridines 0-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 24389509-1 2014 A series of 1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridines differently substituted at positions 1, 5, and 9 have been designed from the pyrano[3,2-c]quinoline derivative 1, a weak inhibitor of acetylcholinesterase (AChE) with predicted ability to bind to the AChE peripheral anionic site (PAS), at the entrance of the catalytic gorge. 1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridines 12-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-212 24389509-1 2014 A series of 1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridines differently substituted at positions 1, 5, and 9 have been designed from the pyrano[3,2-c]quinoline derivative 1, a weak inhibitor of acetylcholinesterase (AChE) with predicted ability to bind to the AChE peripheral anionic site (PAS), at the entrance of the catalytic gorge. 1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridines 12-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-218 24389509-1 2014 A series of 1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridines differently substituted at positions 1, 5, and 9 have been designed from the pyrano[3,2-c]quinoline derivative 1, a weak inhibitor of acetylcholinesterase (AChE) with predicted ability to bind to the AChE peripheral anionic site (PAS), at the entrance of the catalytic gorge. 1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridines 12-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 258-262 24389509-4 2014 Also, the mechanism of AChE inhibition of the most potent compounds has been thoroughly studied by kinetic studies, a propidium displacement assay, and molecular modelling. Propidium 118-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 24395570-3 2014 Cholinergic status was determined by measuring the cumulative capacity of serum acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) to hydrolyze the AChE substrate acetylthiocholine. Acetylthiocholine 173-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 24395570-3 2014 Cholinergic status was determined by measuring the cumulative capacity of serum acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) to hydrolyze the AChE substrate acetylthiocholine. Acetylthiocholine 173-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 24395570-3 2014 Cholinergic status was determined by measuring the cumulative capacity of serum acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) to hydrolyze the AChE substrate acetylthiocholine. Acetylthiocholine 173-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 158-162 24446804-7 2014 Consistent with the binding screen and fluorescence quenching, gamma-mangostin 6 had a much higher affinity for AChE than 9-hydroxycalabaxanthone 9. gamma-mangostin 6 63-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 24310227-3 2014 Compound 10b was one of the most potent inhibitors and was 5-fold more active than tacrine toward AChE, and it also showed a moderate BuChE inhibition with an IC50 value of 200 nM. Tacrine 83-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 24475784-1 2014 Many previous works have demonstrated that acetylcholinesterase (AChE) was enantioselectively inhibited by chiral organophosphorus insecticides (OPs) and that a significant difference in reactivation existed for AChE inactivated by (1R)- versus (1S,3S)-stereoisomers of isomalathion. Caffeine 245-251 acetylcholinesterase (Cartwright blood group) Homo sapiens 212-216 24057572-1 2014 Great efforts have been undertaken in the last decades to develop new oximes to reactivate acetylcholinesterase inhibited by organophosphorus compounds (OP). Oximes 70-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 24057572-1 2014 Great efforts have been undertaken in the last decades to develop new oximes to reactivate acetylcholinesterase inhibited by organophosphorus compounds (OP). Organophosphorus Compounds 125-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-111 24411376-1 2014 A novel acetylcholinesterase (AChE) biosensor based on Ag NPs, carboxylic graphene (CGR) and Nafion (NF) hybrid modified glass carbon electrode (GCE) has been successfully developed. perfluorosulfonic acid 93-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-28 24343873-4 2014 In this paper, we synthesized new tacrine analogs to act on catalytic and peripheral sites of AChE. Tacrine 34-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 24479629-6 2014 The AChE inhibitory activity of leaves and stem chloroform extracts and kaempferol were 80%, 93% and 85.8%, respectively. Chloroform 48-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 24479629-6 2014 The AChE inhibitory activity of leaves and stem chloroform extracts and kaempferol were 80%, 93% and 85.8%, respectively. kaempferol 72-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 24479629-11 2014 In conclusion, the inhibition of AChE by leaf and stem chloroform extracts of A. subintegra could be due to the presence of kaempferol. Chloroform 55-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 24479629-11 2014 In conclusion, the inhibition of AChE by leaf and stem chloroform extracts of A. subintegra could be due to the presence of kaempferol. kaempferol 124-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 22052664-4 2014 Silymarin treatment maintains the integrity of erythrocytes by preventing hemolysis, protein thiol oxidation and by decreasing the activity of AChE. Silymarin 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 24411376-1 2014 A novel acetylcholinesterase (AChE) biosensor based on Ag NPs, carboxylic graphene (CGR) and Nafion (NF) hybrid modified glass carbon electrode (GCE) has been successfully developed. perfluorosulfonic acid 93-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 24411376-1 2014 A novel acetylcholinesterase (AChE) biosensor based on Ag NPs, carboxylic graphene (CGR) and Nafion (NF) hybrid modified glass carbon electrode (GCE) has been successfully developed. Carbon 127-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-28 24411376-1 2014 A novel acetylcholinesterase (AChE) biosensor based on Ag NPs, carboxylic graphene (CGR) and Nafion (NF) hybrid modified glass carbon electrode (GCE) has been successfully developed. Carbon 127-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 24411376-4 2014 The AChE biosensor showed favorable affinity to acetylthiocholine chloride (ATCl) and could catalyze the hydrolysis of ATCl with an apparent Michaelis-Menten constant value of 133 muM, which was then oxidized to produce a detectable and fast response. Acetylthiocholine chloride 48-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 24411376-4 2014 The AChE biosensor showed favorable affinity to acetylthiocholine chloride (ATCl) and could catalyze the hydrolysis of ATCl with an apparent Michaelis-Menten constant value of 133 muM, which was then oxidized to produce a detectable and fast response. atcl 76-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 24411376-4 2014 The AChE biosensor showed favorable affinity to acetylthiocholine chloride (ATCl) and could catalyze the hydrolysis of ATCl with an apparent Michaelis-Menten constant value of 133 muM, which was then oxidized to produce a detectable and fast response. atcl 119-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 24161345-0 2014 The interactions of azure B, a metabolite of methylene blue, with acetylcholinesterase and butyrylcholinesterase. Methylene Blue 45-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 24443939-0 2014 Exploring the physicochemical properties of oxime-reactivation therapeutics for cyclosarin, sarin, tabun, and VX inactivated acetylcholinesterase. Oximes 44-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 24443939-0 2014 Exploring the physicochemical properties of oxime-reactivation therapeutics for cyclosarin, sarin, tabun, and VX inactivated acetylcholinesterase. cyclohexyl methylphosphonofluoridate 80-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-145 24443939-1 2014 The inactivation of acetylcholinesterase (AChE) by organophosphorus agent (OP) compounds is a serious problem regardless of how the individual was exposed. organophosphorus 51-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 24443939-1 2014 The inactivation of acetylcholinesterase (AChE) by organophosphorus agent (OP) compounds is a serious problem regardless of how the individual was exposed. organophosphorus 51-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 24443939-2 2014 The reactivation of OP-inactivated AChE is dependent on the OP conjugate, and commonly a specific oxime is better at reactivating a specific OP conjugate than several diverse OP conjugates. Oximes 98-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 24443939-8 2014 The reactivation of AChE inactivated with either cyclosarin or tabun requires the oxime therapeutic to possess an overall polar-positive surface area. cyclohexyl methylphosphonofluoridate 49-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 24443939-8 2014 The reactivation of AChE inactivated with either cyclosarin or tabun requires the oxime therapeutic to possess an overall polar-positive surface area. tabun 63-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 24443939-8 2014 The reactivation of AChE inactivated with either cyclosarin or tabun requires the oxime therapeutic to possess an overall polar-positive surface area. Oximes 82-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 24443939-9 2014 Oxime therapeutics for the reactivation of sarin-inactivated AChE are conformationally dependent while oxime reverse therapeutics for VX require a compact region with a highly hydrophilic region and two positively charged pyridine rings. Oximes 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 24531296-4 2014 The ACh head groups of both bolaamphiphiles were hydrolyzed by AChE, but the hydrolysis rate was significantly faster for the bolaamphiphile with the shorter aliphatic chain pendant. Acetylcholine 4-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 24531296-6 2014 Our results suggest that the steric environment around the ACh head group of bolaamphiphiles is a major factor affecting the hydrolysis rate of the head groups by AChE. Acetylcholine 59-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 24360998-0 2014 Colorimetric and fluorometric assays for acetylcholinesterase and its inhibitors screening based on a fluorescein derivate. Fluorescein 102-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 24360998-1 2014 A fluorescein-based sensor was developed for the AChE activity assay and the inhibitor screening. Fluorescein 2-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 24360998-3 2014 The colorimetric and fluorometric assays were based on the following processes: (1) owing to the hydrolysis of acetylthiocholine in the presence of AChE, the fluorescein-based probe can rapidly induce 1,4-addition of the hydrolysis product thiocholine to alpha,beta-unsaturated ketone in the compound 1, resulting in strong fluorescence and absorption changes; (2) in the presence of the corresponding inhibitor, the fluorescence enhancement or the absorption change would be inhibited in that the formation of thiocholine was hindered. Acetylthiocholine 111-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 24360998-3 2014 The colorimetric and fluorometric assays were based on the following processes: (1) owing to the hydrolysis of acetylthiocholine in the presence of AChE, the fluorescein-based probe can rapidly induce 1,4-addition of the hydrolysis product thiocholine to alpha,beta-unsaturated ketone in the compound 1, resulting in strong fluorescence and absorption changes; (2) in the presence of the corresponding inhibitor, the fluorescence enhancement or the absorption change would be inhibited in that the formation of thiocholine was hindered. Fluorescein 158-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 24360998-3 2014 The colorimetric and fluorometric assays were based on the following processes: (1) owing to the hydrolysis of acetylthiocholine in the presence of AChE, the fluorescein-based probe can rapidly induce 1,4-addition of the hydrolysis product thiocholine to alpha,beta-unsaturated ketone in the compound 1, resulting in strong fluorescence and absorption changes; (2) in the presence of the corresponding inhibitor, the fluorescence enhancement or the absorption change would be inhibited in that the formation of thiocholine was hindered. Thiocholine 117-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 24360998-3 2014 The colorimetric and fluorometric assays were based on the following processes: (1) owing to the hydrolysis of acetylthiocholine in the presence of AChE, the fluorescein-based probe can rapidly induce 1,4-addition of the hydrolysis product thiocholine to alpha,beta-unsaturated ketone in the compound 1, resulting in strong fluorescence and absorption changes; (2) in the presence of the corresponding inhibitor, the fluorescence enhancement or the absorption change would be inhibited in that the formation of thiocholine was hindered. alpha,beta-unsaturated ketone 255-284 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 24360998-3 2014 The colorimetric and fluorometric assays were based on the following processes: (1) owing to the hydrolysis of acetylthiocholine in the presence of AChE, the fluorescein-based probe can rapidly induce 1,4-addition of the hydrolysis product thiocholine to alpha,beta-unsaturated ketone in the compound 1, resulting in strong fluorescence and absorption changes; (2) in the presence of the corresponding inhibitor, the fluorescence enhancement or the absorption change would be inhibited in that the formation of thiocholine was hindered. Thiocholine 240-251 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 24369842-1 2014 Novel thiazolopyrimidine derivatives have been synthesized via microwave assisted, domino cascade methodology in ionic liquid and evaluated in vitro for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities. thiazolopyrimidine 6-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 24369842-1 2014 Novel thiazolopyrimidine derivatives have been synthesized via microwave assisted, domino cascade methodology in ionic liquid and evaluated in vitro for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities. thiazolopyrimidine 6-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-185 24413757-3 2014 Organophosphorus compounds (OPs) are pesticides due to their acute insecticidal effects mediated by the inhibition of acetylcholinesterase, although other esterases as neuropathy target esterase (NTE) can also be inhibited. Organophosphorus Compounds 0-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 24413757-3 2014 Organophosphorus compounds (OPs) are pesticides due to their acute insecticidal effects mediated by the inhibition of acetylcholinesterase, although other esterases as neuropathy target esterase (NTE) can also be inhibited. Organophosphorus Compounds 28-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 24223422-1 2014 This paper describes the molecular modeling design, synthesis and characterization of a new bio-inspired hexapeptide of acetylcholinesterase enzyme and its interaction with the organophosphate pesticide dichlorvos monitored by UV-Vis spectroscopy and mass spectrometry. Organophosphates 177-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 24411376-0 2014 A novel acetylcholinesterase biosensor based on carboxylic graphene coated with silver nanoparticles for pesticide detection. carboxylic graphene 48-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-28 24411376-0 2014 A novel acetylcholinesterase biosensor based on carboxylic graphene coated with silver nanoparticles for pesticide detection. Silver 80-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-28 24411376-1 2014 A novel acetylcholinesterase (AChE) biosensor based on Ag NPs, carboxylic graphene (CGR) and Nafion (NF) hybrid modified glass carbon electrode (GCE) has been successfully developed. carboxylic graphene 63-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-28 24411376-1 2014 A novel acetylcholinesterase (AChE) biosensor based on Ag NPs, carboxylic graphene (CGR) and Nafion (NF) hybrid modified glass carbon electrode (GCE) has been successfully developed. carboxylic graphene 63-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 24251311-3 2014 The fluorescence of the AuNCs was quenched by thiocholine that was produced from the AChE hydrolysis of S-acetylthiocholine iodide (ACTI) to detect the AChE activity. Thiocholine 46-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 24225492-0 2014 Thiocholine mediated stabilization of in situ produced CdS quantum dots: application for the detection of acetylcholinesterase activity and inhibitors. Thiocholine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 24251311-3 2014 The fluorescence of the AuNCs was quenched by thiocholine that was produced from the AChE hydrolysis of S-acetylthiocholine iodide (ACTI) to detect the AChE activity. Thiocholine 46-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 24251311-3 2014 The fluorescence of the AuNCs was quenched by thiocholine that was produced from the AChE hydrolysis of S-acetylthiocholine iodide (ACTI) to detect the AChE activity. acetylthiocholine iodide 104-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 24251311-3 2014 The fluorescence of the AuNCs was quenched by thiocholine that was produced from the AChE hydrolysis of S-acetylthiocholine iodide (ACTI) to detect the AChE activity. acetylthiocholine iodide 104-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 24251311-3 2014 The fluorescence of the AuNCs was quenched by thiocholine that was produced from the AChE hydrolysis of S-acetylthiocholine iodide (ACTI) to detect the AChE activity. acetylthiocholine iodide 132-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 24251311-3 2014 The fluorescence of the AuNCs was quenched by thiocholine that was produced from the AChE hydrolysis of S-acetylthiocholine iodide (ACTI) to detect the AChE activity. acetylthiocholine iodide 132-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 24225492-0 2014 Thiocholine mediated stabilization of in situ produced CdS quantum dots: application for the detection of acetylcholinesterase activity and inhibitors. Cadmium 55-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 24225492-2 2014 The high toxicity of these compounds arises from their ability to inhibit acetylcholinesterase from degrading acetylcholine (ACh), which could affect the physiology of the nervous system with serious or fatal consequences. Acetylcholine 125-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 24225492-4 2014 The principle of this approach is based on the hydrolysis of acetylthiocholine (ATCh) by AChE, which yields the thiol-bearing compound thiocholine (TCh) that at trace concentrations stabilized the in situ generated CdS quantum dots (QDs). Acetylthiocholine 61-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 24225492-4 2014 The principle of this approach is based on the hydrolysis of acetylthiocholine (ATCh) by AChE, which yields the thiol-bearing compound thiocholine (TCh) that at trace concentrations stabilized the in situ generated CdS quantum dots (QDs). Acetylthiocholine 80-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 24225492-4 2014 The principle of this approach is based on the hydrolysis of acetylthiocholine (ATCh) by AChE, which yields the thiol-bearing compound thiocholine (TCh) that at trace concentrations stabilized the in situ generated CdS quantum dots (QDs). Sulfhydryl Compounds 112-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 24225492-4 2014 The principle of this approach is based on the hydrolysis of acetylthiocholine (ATCh) by AChE, which yields the thiol-bearing compound thiocholine (TCh) that at trace concentrations stabilized the in situ generated CdS quantum dots (QDs). Thiocholine 67-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 24225492-4 2014 The principle of this approach is based on the hydrolysis of acetylthiocholine (ATCh) by AChE, which yields the thiol-bearing compound thiocholine (TCh) that at trace concentrations stabilized the in situ generated CdS quantum dots (QDs). Thiocholine 81-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 24225492-4 2014 The principle of this approach is based on the hydrolysis of acetylthiocholine (ATCh) by AChE, which yields the thiol-bearing compound thiocholine (TCh) that at trace concentrations stabilized the in situ generated CdS quantum dots (QDs). Cadmium 215-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 24225492-7 2014 Furthermore, this novel and highly sensitive sensing system allows the detection of 80 pM of the AChE inhibitor paraoxon and 100 nM of galanthamine. Paraoxon 112-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 24515809-3 2014 Although clomazone exhibits low mammalian toxicity and is selective towards certain plant species, studies have shown that it does inhibit AChE and catalase activities. clomazone 9-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 24216754-2 2014 Here, we report for the first time the use of the human acetylcholinesterase (AChE) as an enzyme for the design and synthesis of new potent heterodimeric huprine-based inhibitors. huprine 154-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 24216754-2 2014 Here, we report for the first time the use of the human acetylcholinesterase (AChE) as an enzyme for the design and synthesis of new potent heterodimeric huprine-based inhibitors. huprine 154-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 24487260-4 2014 These agents work through altering the transmission and breakdown of acetylcholine by binding to, and inactivating, acetylcholinesterase. Acetylcholine 69-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 24919672-0 2014 A sensitive amperometric acetylcholine biosensor based on carbon nanosphere and acetylcholinesterase modified electrode for detection of pesticide residues. Acetylcholine 25-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-100 24919672-1 2014 A sensitive biosensor based on acetylcholinesterase (AChE) and carbon nanosphere (CNS) immobilized on a glassy carbon electrode was developed for the detection of pesticides by the inhibition of AChE activity. Carbon 63-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 24919672-1 2014 A sensitive biosensor based on acetylcholinesterase (AChE) and carbon nanosphere (CNS) immobilized on a glassy carbon electrode was developed for the detection of pesticides by the inhibition of AChE activity. Carbon 111-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 25054066-6 2014 Our molecular docking and simulation have predicted high binding affinity of secondary metabolite (C28H34N2O6) to AChE. c28h34n2o6 99-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 25050335-2 2014 3D-pharmacophore models of AChE and BuChE enzyme inhibitors have been developed from xanthostigmine derivatives through HypoGen and validated using test set, Fischer"s randomization technique. xanthostigmine 85-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 24694376-0 2014 Synthesis and in vitro evaluation of 1,3,4-thiadiazol-2-yl urea derivatives as novel AChE inhibitors. 1,3,4-thiadiazol-2-yl urea 37-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 24694376-1 2014 1,3,4-Thiadiazole and urea group were hybridized to form new molecular skeleton and 11 compounds were synthesized and evaluated as acetylcholinesterase (AChE) inhibitors. 1,3,4-thiadiazole 0-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-151 24694376-1 2014 1,3,4-Thiadiazole and urea group were hybridized to form new molecular skeleton and 11 compounds were synthesized and evaluated as acetylcholinesterase (AChE) inhibitors. 1,3,4-thiadiazole 0-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 24694376-1 2014 1,3,4-Thiadiazole and urea group were hybridized to form new molecular skeleton and 11 compounds were synthesized and evaluated as acetylcholinesterase (AChE) inhibitors. Urea 22-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-151 24694376-1 2014 1,3,4-Thiadiazole and urea group were hybridized to form new molecular skeleton and 11 compounds were synthesized and evaluated as acetylcholinesterase (AChE) inhibitors. Urea 22-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 24694376-2 2014 Most of them showed comparable effects in inhibition of AChE, especially compound 6b which exhibited activity with IC50 value 1.17 microM, as strong as galanthamine. Galantamine 152-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 23981668-2 2014 The peripheral anionic site (PAS) of AChE has been indicated as the amyloid-beta (Abeta) binding domain. Aminosalicylic Acid 29-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 23981668-8 2014 The results of further dot blot assays, thioflavin T fluorescence assays, and electron microscopy imaging experiments, indicated that the N-terminal synthetic peptide AChE7-20 had nearly the same ability as AChE with regard to triggering Abeta aggregation and deposition. thioflavin T 40-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 33412688-5 2014 Sinapine (sinapoyl choline) is considered to be an acetylcholinesterase inhibitor which might have therapeutic applications in various disease treatments. sinapine 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 33412688-5 2014 Sinapine (sinapoyl choline) is considered to be an acetylcholinesterase inhibitor which might have therapeutic applications in various disease treatments. sinapoyl choline 10-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 25756672-1 2014 Monte Carlo method has been used as a computational tool for building QSAR models for the reactivation of sarin inhibited acetylcholinesterase (AChE) by quaternary pyridinium oximes. quaternary pyridinium oximes 153-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148 24898642-2 2014 Acetylcholinesterase (AChE) catalyzes the hydrolysis of the cholinergic neurotransmitter acetylcholine. Acetylcholine 89-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24773345-0 2014 Preparation, in vitro screening and molecular modelling of monoquaternary compounds related to the selective acetylcholinesterase inhibitor BW284c51. Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide 140-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-129 24261316-1 2014 BACKGROUND: The first-line medication gabapentin and the acetylcholinesterase inhibitor donepezil represent a new promising combination to improve treatment outcomes for patients with severe neuropathic pain. Donepezil 88-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 25345511-5 2014 This imbalance and change in the AChE/BuChE ratio causes cholinergic deficit in the brain, i.e. deficiency in the brain neurotransmitter acetylcholine. Acetylcholine 137-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 24344993-0 2014 Computational evidence for the reactivation process of human acetylcholinesterase inhibited by carbamates. Carbamates 95-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 24344993-1 2014 Acetylcholinesterase (AChE) is responsible for hydrolysis of acetylcholine (ACh), a function, which if disrupted, leads to cholinergic syndrome. Acetylcholine 61-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24344993-1 2014 Acetylcholinesterase (AChE) is responsible for hydrolysis of acetylcholine (ACh), a function, which if disrupted, leads to cholinergic syndrome. Acetylcholine 61-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 24344993-1 2014 Acetylcholinesterase (AChE) is responsible for hydrolysis of acetylcholine (ACh), a function, which if disrupted, leads to cholinergic syndrome. Acetylcholine 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24344993-2 2014 Carbamates (CB) and organophosphorus compounds (OP) are AChE inhibitors, toxic and capable of causing severe poisoning or death to exposed individuals. Carbamates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 24344993-2 2014 Carbamates (CB) and organophosphorus compounds (OP) are AChE inhibitors, toxic and capable of causing severe poisoning or death to exposed individuals. organophosphorus 20-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 24344993-5 2014 In this work, we evaluated the affinity and reactivity of oximes with activity already reported against AChE inhibited by the OP chemical warfare agent ciclosarin, with MmAChE and HsAChE active sites inhibited by the CB pesticide carbofuran. Oximes 58-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 24344993-5 2014 In this work, we evaluated the affinity and reactivity of oximes with activity already reported against AChE inhibited by the OP chemical warfare agent ciclosarin, with MmAChE and HsAChE active sites inhibited by the CB pesticide carbofuran. ciclosarin 152-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 24344993-6 2014 Thus, our theoretical data indicate that HLO-7, BI-6 and K005 compounds may be promising reactivators of AChE inhibited by carbofuran. Carbofuran 123-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 25312618-3 2014 Some flavonoid derivatives have been demonstrated to inhibit both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) to varying extent, which are called the sister enzymes linked to the pathogenesis of AD. Flavonoids 5-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 25312618-3 2014 Some flavonoid derivatives have been demonstrated to inhibit both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) to varying extent, which are called the sister enzymes linked to the pathogenesis of AD. Flavonoids 5-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 23904256-7 2014 Among tested nanoparticles, Cl-AgNP was found to be the most potent inhibitor of both AChE and BChE. cl-agnp 28-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 24473150-0 2014 Copper, aluminum, iron and calcium inhibit human acetylcholinesterase in vitro. Copper 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 24473150-0 2014 Copper, aluminum, iron and calcium inhibit human acetylcholinesterase in vitro. Aluminum 8-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 24473150-0 2014 Copper, aluminum, iron and calcium inhibit human acetylcholinesterase in vitro. Iron 18-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 24473150-0 2014 Copper, aluminum, iron and calcium inhibit human acetylcholinesterase in vitro. Calcium 27-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 24473150-3 2014 In this work, metal salts aluminum chloride, calcium chloride, cupric chloride, ferric chloride, potassium chloride, magnesium chloride and sodium chloride were tested for their ability to inhibit AChE. metal salts 14-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-201 24473150-3 2014 In this work, metal salts aluminum chloride, calcium chloride, cupric chloride, ferric chloride, potassium chloride, magnesium chloride and sodium chloride were tested for their ability to inhibit AChE. Aluminum Chloride 26-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-201 24473150-3 2014 In this work, metal salts aluminum chloride, calcium chloride, cupric chloride, ferric chloride, potassium chloride, magnesium chloride and sodium chloride were tested for their ability to inhibit AChE. Calcium Chloride 45-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-201 24473150-3 2014 In this work, metal salts aluminum chloride, calcium chloride, cupric chloride, ferric chloride, potassium chloride, magnesium chloride and sodium chloride were tested for their ability to inhibit AChE. cupric chloride 63-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-201 24473150-3 2014 In this work, metal salts aluminum chloride, calcium chloride, cupric chloride, ferric chloride, potassium chloride, magnesium chloride and sodium chloride were tested for their ability to inhibit AChE. ferric chloride 80-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-201 24473150-3 2014 In this work, metal salts aluminum chloride, calcium chloride, cupric chloride, ferric chloride, potassium chloride, magnesium chloride and sodium chloride were tested for their ability to inhibit AChE. Potassium Chloride 97-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-201 24473150-3 2014 In this work, metal salts aluminum chloride, calcium chloride, cupric chloride, ferric chloride, potassium chloride, magnesium chloride and sodium chloride were tested for their ability to inhibit AChE. Magnesium Chloride 117-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-201 24473150-3 2014 In this work, metal salts aluminum chloride, calcium chloride, cupric chloride, ferric chloride, potassium chloride, magnesium chloride and sodium chloride were tested for their ability to inhibit AChE. Sodium Chloride 140-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-201 24473150-6 2014 However, aluminum, cupric, ferric and calcium ions were able to inhibit AChE via noncompetitive mechanism of inhibition. Aluminum 9-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 24473150-6 2014 However, aluminum, cupric, ferric and calcium ions were able to inhibit AChE via noncompetitive mechanism of inhibition. cupric 19-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 24473150-6 2014 However, aluminum, cupric, ferric and calcium ions were able to inhibit AChE via noncompetitive mechanism of inhibition. Ferric enterobactin ion 27-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 24473150-6 2014 However, aluminum, cupric, ferric and calcium ions were able to inhibit AChE via noncompetitive mechanism of inhibition. Calcium 38-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 24001830-0 2014 Acetylcholinesterase based biosensor for monitoring of Malathion and Acephate in food samples: a voltammetric study. Malathion 55-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24001830-0 2014 Acetylcholinesterase based biosensor for monitoring of Malathion and Acephate in food samples: a voltammetric study. acephate 69-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24001830-1 2014 Acetylcholinesterase (AChE) biosensor was developed through silica sol-gel (SiSG) immobilisation of AChE on the carbon paste electrode (CPE) and used as working electrode. silica sol-gel 60-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24001830-1 2014 Acetylcholinesterase (AChE) biosensor was developed through silica sol-gel (SiSG) immobilisation of AChE on the carbon paste electrode (CPE) and used as working electrode. silica sol-gel 60-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 24001830-1 2014 Acetylcholinesterase (AChE) biosensor was developed through silica sol-gel (SiSG) immobilisation of AChE on the carbon paste electrode (CPE) and used as working electrode. silica sol-gel 60-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 24001830-1 2014 Acetylcholinesterase (AChE) biosensor was developed through silica sol-gel (SiSG) immobilisation of AChE on the carbon paste electrode (CPE) and used as working electrode. Carbon 112-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24001830-1 2014 Acetylcholinesterase (AChE) biosensor was developed through silica sol-gel (SiSG) immobilisation of AChE on the carbon paste electrode (CPE) and used as working electrode. Carbon 112-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 24001830-1 2014 Acetylcholinesterase (AChE) biosensor was developed through silica sol-gel (SiSG) immobilisation of AChE on the carbon paste electrode (CPE) and used as working electrode. Carbon 112-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 24001830-2 2014 AChE catalyses the cleavage of acetylthiocholine chloride (ASChCl or substrate) to thiocholine, which was oxidised to give a disulphide compound by dimerisation at 0.60V versus saturated calomel electrode. Acetylthiocholine chloride 31-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 24001830-2 2014 AChE catalyses the cleavage of acetylthiocholine chloride (ASChCl or substrate) to thiocholine, which was oxidised to give a disulphide compound by dimerisation at 0.60V versus saturated calomel electrode. aschcl 59-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 24001830-2 2014 AChE catalyses the cleavage of acetylthiocholine chloride (ASChCl or substrate) to thiocholine, which was oxidised to give a disulphide compound by dimerisation at 0.60V versus saturated calomel electrode. Thiocholine 37-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 24001830-2 2014 AChE catalyses the cleavage of acetylthiocholine chloride (ASChCl or substrate) to thiocholine, which was oxidised to give a disulphide compound by dimerisation at 0.60V versus saturated calomel electrode. disulphide 125-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 25484901-0 2014 Bioactive paper sensor based on the acetylcholinesterase for the rapid detection of organophosphate and carbamate pesticides. Organophosphates 84-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 25484901-0 2014 Bioactive paper sensor based on the acetylcholinesterase for the rapid detection of organophosphate and carbamate pesticides. Carbamates 104-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 25484901-3 2014 In this study, a bioactive paper-based sensor was developed for detection of acetylcholinesterase (AChE) inhibitors including organophosphate and carbamate pesticides. Organophosphates 126-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 25484901-3 2014 In this study, a bioactive paper-based sensor was developed for detection of acetylcholinesterase (AChE) inhibitors including organophosphate and carbamate pesticides. Organophosphates 126-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 25484901-3 2014 In this study, a bioactive paper-based sensor was developed for detection of acetylcholinesterase (AChE) inhibitors including organophosphate and carbamate pesticides. Carbamates 146-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 25484901-3 2014 In this study, a bioactive paper-based sensor was developed for detection of acetylcholinesterase (AChE) inhibitors including organophosphate and carbamate pesticides. Carbamates 146-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 25484901-4 2014 Based on the Ellman colorimetric assay, the assay strip is composed of a paper support (1 x 10 cm), onto which a biopolymer chitosan gel immobilized in crosslinking by glutaraldehyde with AChE and 5,5"-dithiobis(2-nitrobenzoic) acid (DTNB) and uses acetylthiocholine iodide (ATChI) as an outside reagent. Chitosan 124-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-192 25484901-4 2014 Based on the Ellman colorimetric assay, the assay strip is composed of a paper support (1 x 10 cm), onto which a biopolymer chitosan gel immobilized in crosslinking by glutaraldehyde with AChE and 5,5"-dithiobis(2-nitrobenzoic) acid (DTNB) and uses acetylthiocholine iodide (ATChI) as an outside reagent. Glutaral 168-182 acetylcholinesterase (Cartwright blood group) Homo sapiens 188-192 24699279-5 2014 The AChE species capable of triggering the biggest increase in PS1 levels is a complex of AChE with the membrane anchoring subunit proline-rich membrane anchor (PRiMA), which restricts the localization of the resulting AChE tetramer to the outer plasma membrane. Proline 131-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 24699279-5 2014 The AChE species capable of triggering the biggest increase in PS1 levels is a complex of AChE with the membrane anchoring subunit proline-rich membrane anchor (PRiMA), which restricts the localization of the resulting AChE tetramer to the outer plasma membrane. Proline 131-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 24699279-5 2014 The AChE species capable of triggering the biggest increase in PS1 levels is a complex of AChE with the membrane anchoring subunit proline-rich membrane anchor (PRiMA), which restricts the localization of the resulting AChE tetramer to the outer plasma membrane. Proline 131-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 23527625-0 2014 Reactivation steps by 2-PAM of tabun-inhibited human acetylcholinesterase: reducing the computational cost in hybrid QM/MM methods. tabun 31-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 23527625-1 2014 The present work describes a simple integrated Quantum Mechanics/Molecular Mechanics method developed to study the reactivation steps by pralidoxime (2-PAM) of acetylcholinesterase (AChE) inhibited by the neurotoxic agent Tabun. pralidoxime 137-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-180 23527625-1 2014 The present work describes a simple integrated Quantum Mechanics/Molecular Mechanics method developed to study the reactivation steps by pralidoxime (2-PAM) of acetylcholinesterase (AChE) inhibited by the neurotoxic agent Tabun. pralidoxime 137-148 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-186 24138113-1 2014 A series of hitherto unreported piperidone embedded alpha,beta-unsaturated ketones were synthesized efficiently in ionic solvent and evaluated for cholinesterase inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Piperidones 32-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-218 24138113-1 2014 A series of hitherto unreported piperidone embedded alpha,beta-unsaturated ketones were synthesized efficiently in ionic solvent and evaluated for cholinesterase inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. alpha,beta-unsaturated ketones 52-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-218 23373657-2 2014 The present review discusses these different compounds with pyrrolo-isoxazole containing nucleus for their neuroprotective, anti-stress, acetylcholinesterase and anti-amnestic, antihypertensive and antibacterial activities. pyrrolo-isoxazole 60-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 24251806-5 2014 Besides its high potency, donepezil also exhibited high selectivity for AChE and a very low toxicity. Donepezil 26-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 25202788-5 2014 In this connection, the efficacy of acetylcholinesterase inhibitors: galantamine (reminil),neuromidin, rivastigmine in the treatment of PD patients with dementia is discussed. Galantamine 69-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 25202788-5 2014 In this connection, the efficacy of acetylcholinesterase inhibitors: galantamine (reminil),neuromidin, rivastigmine in the treatment of PD patients with dementia is discussed. amiridine 91-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 25202788-5 2014 In this connection, the efficacy of acetylcholinesterase inhibitors: galantamine (reminil),neuromidin, rivastigmine in the treatment of PD patients with dementia is discussed. Rivastigmine 103-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-56 24392323-0 2013 Acetylcholinesterase function in apoptotic retina pigment epithelial cells induced by H2O2. Hydrogen Peroxide 86-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24392323-1 2013 AIM: To investigate the acetylcholinesterase (AChE) expression involved in retina pigment epithelial (RPE) apoptosis induced by higher concentrations H2O2. Hydrogen Peroxide 150-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-44 24392323-1 2013 AIM: To investigate the acetylcholinesterase (AChE) expression involved in retina pigment epithelial (RPE) apoptosis induced by higher concentrations H2O2. Hydrogen Peroxide 150-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 24392323-6 2013 When H2O2 >500micromol/L, AChE expression showed an increase after 2h, and this concentration was selected for the present study. Hydrogen Peroxide 5-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 24392323-6 2013 When H2O2 >500micromol/L, AChE expression showed an increase after 2h, and this concentration was selected for the present study. Deuterium 70-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 24392323-7 2013 RPE cell was induced with 1 000micromol/L H2O2 for 2h, compared to the control group, cell activity decline detected by MTT, AChE and PARP-1 protein expression was significantly increased detected by Western blotting. Hydrogen Peroxide 42-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 24392323-7 2013 RPE cell was induced with 1 000micromol/L H2O2 for 2h, compared to the control group, cell activity decline detected by MTT, AChE and PARP-1 protein expression was significantly increased detected by Western blotting. Deuterium 51-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 125-129 24392323-8 2013 AChE immunofluorescence staining was positive in RPE cell after H2O2 incubate 2h. Hydrogen Peroxide 64-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 24392323-8 2013 AChE immunofluorescence staining was positive in RPE cell after H2O2 incubate 2h. Deuterium 78-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 24392323-11 2013 Stimulation with H2O2 caused the stable increase of AChE expression in RPE cells, which may indicate that AChE may be an important role in AMD. Hydrogen Peroxide 17-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 24392323-11 2013 Stimulation with H2O2 caused the stable increase of AChE expression in RPE cells, which may indicate that AChE may be an important role in AMD. Hydrogen Peroxide 17-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 24229314-3 2013 These complexes were subsequently conjugated to polyclonal antibody-functionalized acetylcholinesterase (AchE) and dispersed in acetylcholine (Ach) solution. Acetylcholine 83-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 24299064-9 2013 The AChE-catalyzed hydrolysis of acetylthiocholine to the thiol-functionalized thiocholine enabled the probing of the enzymatic activity of AChE through the hemin/G-quadruplex-catalyzed aerobic oxidation of thiocholine to the respective disulfide and the concomitant generation of the fluorescent resorufin product. Acetylthiocholine 33-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 24299064-9 2013 The AChE-catalyzed hydrolysis of acetylthiocholine to the thiol-functionalized thiocholine enabled the probing of the enzymatic activity of AChE through the hemin/G-quadruplex-catalyzed aerobic oxidation of thiocholine to the respective disulfide and the concomitant generation of the fluorescent resorufin product. Acetylthiocholine 33-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 24299064-9 2013 The AChE-catalyzed hydrolysis of acetylthiocholine to the thiol-functionalized thiocholine enabled the probing of the enzymatic activity of AChE through the hemin/G-quadruplex-catalyzed aerobic oxidation of thiocholine to the respective disulfide and the concomitant generation of the fluorescent resorufin product. Sulfhydryl Compounds 58-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 24299064-9 2013 The AChE-catalyzed hydrolysis of acetylthiocholine to the thiol-functionalized thiocholine enabled the probing of the enzymatic activity of AChE through the hemin/G-quadruplex-catalyzed aerobic oxidation of thiocholine to the respective disulfide and the concomitant generation of the fluorescent resorufin product. Sulfhydryl Compounds 58-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 24299064-9 2013 The AChE-catalyzed hydrolysis of acetylthiocholine to the thiol-functionalized thiocholine enabled the probing of the enzymatic activity of AChE through the hemin/G-quadruplex-catalyzed aerobic oxidation of thiocholine to the respective disulfide and the concomitant generation of the fluorescent resorufin product. Thiocholine 39-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 24299064-9 2013 The AChE-catalyzed hydrolysis of acetylthiocholine to the thiol-functionalized thiocholine enabled the probing of the enzymatic activity of AChE through the hemin/G-quadruplex-catalyzed aerobic oxidation of thiocholine to the respective disulfide and the concomitant generation of the fluorescent resorufin product. Thiocholine 39-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 24299064-9 2013 The AChE-catalyzed hydrolysis of acetylthiocholine to the thiol-functionalized thiocholine enabled the probing of the enzymatic activity of AChE through the hemin/G-quadruplex-catalyzed aerobic oxidation of thiocholine to the respective disulfide and the concomitant generation of the fluorescent resorufin product. Thiocholine 79-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 24299064-9 2013 The AChE-catalyzed hydrolysis of acetylthiocholine to the thiol-functionalized thiocholine enabled the probing of the enzymatic activity of AChE through the hemin/G-quadruplex-catalyzed aerobic oxidation of thiocholine to the respective disulfide and the concomitant generation of the fluorescent resorufin product. Thiocholine 79-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 24299064-9 2013 The AChE-catalyzed hydrolysis of acetylthiocholine to the thiol-functionalized thiocholine enabled the probing of the enzymatic activity of AChE through the hemin/G-quadruplex-catalyzed aerobic oxidation of thiocholine to the respective disulfide and the concomitant generation of the fluorescent resorufin product. Disulfides 237-246 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 24299064-9 2013 The AChE-catalyzed hydrolysis of acetylthiocholine to the thiol-functionalized thiocholine enabled the probing of the enzymatic activity of AChE through the hemin/G-quadruplex-catalyzed aerobic oxidation of thiocholine to the respective disulfide and the concomitant generation of the fluorescent resorufin product. Disulfides 237-246 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 24299064-9 2013 The AChE-catalyzed hydrolysis of acetylthiocholine to the thiol-functionalized thiocholine enabled the probing of the enzymatic activity of AChE through the hemin/G-quadruplex-catalyzed aerobic oxidation of thiocholine to the respective disulfide and the concomitant generation of the fluorescent resorufin product. resorufin 297-306 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 24299064-9 2013 The AChE-catalyzed hydrolysis of acetylthiocholine to the thiol-functionalized thiocholine enabled the probing of the enzymatic activity of AChE through the hemin/G-quadruplex-catalyzed aerobic oxidation of thiocholine to the respective disulfide and the concomitant generation of the fluorescent resorufin product. resorufin 297-306 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 24220173-3 2013 Two compounds, 1-(10-(pyridinium-1-yl)decyl)quinolinium dibromide and 1-(12-(pyridinium-1-yl)dodecyl)quinolinium dibromide, showed very promising affinity for acetylcholinesterase with their IC50 values reaching nM inhibition of acetylcholinesterase. 1-(10-(pyridinium-1-yl)decyl)quinolinium dibromide 15-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 24220173-3 2013 Two compounds, 1-(10-(pyridinium-1-yl)decyl)quinolinium dibromide and 1-(12-(pyridinium-1-yl)dodecyl)quinolinium dibromide, showed very promising affinity for acetylcholinesterase with their IC50 values reaching nM inhibition of acetylcholinesterase. 1-(10-(pyridinium-1-yl)decyl)quinolinium dibromide 15-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 229-249 24220173-3 2013 Two compounds, 1-(10-(pyridinium-1-yl)decyl)quinolinium dibromide and 1-(12-(pyridinium-1-yl)dodecyl)quinolinium dibromide, showed very promising affinity for acetylcholinesterase with their IC50 values reaching nM inhibition of acetylcholinesterase. 1-(12-(pyridinium-1-yl)dodecyl)quinolinium dibromide 70-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 24220173-3 2013 Two compounds, 1-(10-(pyridinium-1-yl)decyl)quinolinium dibromide and 1-(12-(pyridinium-1-yl)dodecyl)quinolinium dibromide, showed very promising affinity for acetylcholinesterase with their IC50 values reaching nM inhibition of acetylcholinesterase. 1-(12-(pyridinium-1-yl)dodecyl)quinolinium dibromide 70-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 229-249 23962483-0 2013 Investigation of kinetic interactions between approved oximes and human acetylcholinesterase inhibited by pesticide carbamates. Oximes 55-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 23962483-1 2013 Carbamates are widely used for pest control and act primarily by inhibition of insect and mammalian acetylcholinesterase (AChE). Carbamates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 23962483-1 2013 Carbamates are widely used for pest control and act primarily by inhibition of insect and mammalian acetylcholinesterase (AChE). Carbamates 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 23962483-4 2013 Therefore, we performed an in vitro kinetic study to investigate the effect of clinically used oximes on carbamoylation and decarbamoylation of human AChE. Oximes 95-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 23962483-5 2013 It became evident that pralidoxime and obidoxime in therapeutic concentrations aggravate the inhibition of AChE by carbaryl and propoxur, with obidoxime being substantially more potent compared to 2-PAM. pralidoxime 23-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 23962483-5 2013 It became evident that pralidoxime and obidoxime in therapeutic concentrations aggravate the inhibition of AChE by carbaryl and propoxur, with obidoxime being substantially more potent compared to 2-PAM. Obidoxime Chloride 39-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 23962483-5 2013 It became evident that pralidoxime and obidoxime in therapeutic concentrations aggravate the inhibition of AChE by carbaryl and propoxur, with obidoxime being substantially more potent compared to 2-PAM. Carbaryl 115-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 23962483-5 2013 It became evident that pralidoxime and obidoxime in therapeutic concentrations aggravate the inhibition of AChE by carbaryl and propoxur, with obidoxime being substantially more potent compared to 2-PAM. Propoxur 128-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 23962483-5 2013 It became evident that pralidoxime and obidoxime in therapeutic concentrations aggravate the inhibition of AChE by carbaryl and propoxur, with obidoxime being substantially more potent compared to 2-PAM. Obidoxime Chloride 143-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 24157926-1 2013 The toxicity of organophosphorus nerve agents or pesticides arises from accumulation of acetylcholine and overstimulation of both muscarinic and nicotinic acetylcholine receptors (mAChRs and nAChRs) due to inhibition of acetylcholinesterase (AChE). organophosphorus 16-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 242-246 24157926-2 2013 Standard treatment by administration of atropine and oximes, e.g., obidoxime or pralidoxime, focuses on antagonism of mAChRs and reactivation of AChE, whereas nicotinic malfunction is not directly treated. Atropine 40-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 24157926-2 2013 Standard treatment by administration of atropine and oximes, e.g., obidoxime or pralidoxime, focuses on antagonism of mAChRs and reactivation of AChE, whereas nicotinic malfunction is not directly treated. Oximes 53-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 24157926-2 2013 Standard treatment by administration of atropine and oximes, e.g., obidoxime or pralidoxime, focuses on antagonism of mAChRs and reactivation of AChE, whereas nicotinic malfunction is not directly treated. Obidoxime Chloride 67-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 24157926-2 2013 Standard treatment by administration of atropine and oximes, e.g., obidoxime or pralidoxime, focuses on antagonism of mAChRs and reactivation of AChE, whereas nicotinic malfunction is not directly treated. pralidoxime 80-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 24157926-8 2013 Since quaternary ammonium molecules are known to inhibit AChE, the obtained affinity constants of the tested bispyridinium compounds were compared with the inhibition of human AChE. quaternary ammonium 6-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 24157926-9 2013 In competition experiments, bispyridinium derivatives of longer linker length displaced [(3)H]epibatidine and inhibited AChE strongly. bispyridinium 28-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 24157926-10 2013 Bispyridinium compounds with short linkers, at most, have an allosteric interaction with the [(3)H]epibatidine binding sites and barely inhibited AChE. bispyridinium 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 23526889-1 2013 The recognition and association of donepezil with acetylcholinesterase (AChE) has been extensively studied in the past several decades because of the former"s use as a palliative treatment for mild Alzheimer disease. Donepezil 35-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 23526889-1 2013 The recognition and association of donepezil with acetylcholinesterase (AChE) has been extensively studied in the past several decades because of the former"s use as a palliative treatment for mild Alzheimer disease. Donepezil 35-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 23526889-2 2013 Herein we examine the conformational properties of donepezil and we re-examine the donepezil-AChE crystal structure using combined quantum mechanical/molecular mechanical (QM/MM) X-ray refinement tools. Donepezil 83-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 23526889-4 2013 The donepezil-AChE complex (PDB 1EVE) was also re-refined through a parallel QM/MM X-ray refinement approach based on an in-house ab initio code QUICK, which uses the message passing interface (MPI) in a distributed SCF algorithm to accelerate the calculation via parallelization. Donepezil 4-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 23526889-5 2013 In the QM/MM re-refined donepezil structure, coordinate errors that previously existed in the PDB deposited geometry were improved leading to an improvement of the modeling of the interaction between donepezil and the aromatic side chains located in the AChE active site gorge. Donepezil 24-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 254-258 23526889-5 2013 In the QM/MM re-refined donepezil structure, coordinate errors that previously existed in the PDB deposited geometry were improved leading to an improvement of the modeling of the interaction between donepezil and the aromatic side chains located in the AChE active site gorge. Donepezil 200-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 254-258 24160846-3 2013 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce betaine and H2O2 which can quench the photoluminescence (PL) of SiQDs. Acetylcholine 47-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 24160846-3 2013 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce betaine and H2O2 which can quench the photoluminescence (PL) of SiQDs. Acetylcholine 47-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 24160846-3 2013 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce betaine and H2O2 which can quench the photoluminescence (PL) of SiQDs. Acetylcholine 71-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 24160846-3 2013 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce betaine and H2O2 which can quench the photoluminescence (PL) of SiQDs. Acetylcholine 71-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 24160846-3 2013 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce betaine and H2O2 which can quench the photoluminescence (PL) of SiQDs. Choline 53-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 24160846-3 2013 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce betaine and H2O2 which can quench the photoluminescence (PL) of SiQDs. Choline 53-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 24160846-3 2013 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce betaine and H2O2 which can quench the photoluminescence (PL) of SiQDs. Betaine 201-208 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 24160846-3 2013 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce betaine and H2O2 which can quench the photoluminescence (PL) of SiQDs. Betaine 201-208 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 24160846-3 2013 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce betaine and H2O2 which can quench the photoluminescence (PL) of SiQDs. Hydrogen Peroxide 213-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 24160846-3 2013 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce betaine and H2O2 which can quench the photoluminescence (PL) of SiQDs. Hydrogen Peroxide 213-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 24160846-4 2013 Upon the addition of pesticides, the activity of AChE is inhibited, leading to the decrease of the generated H2O2, and hence the PL of SiQDs increases. Hydrogen Peroxide 109-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 24312449-7 2013 The calculated activation barriers support the superiority of neutral oximes for the activation of tabun-inhibited AChE compared to charged oximes. Oximes 70-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 24312449-9 2013 Docking studies revealed that the poor binding affinity of simple neutral oxime drugs such as 3-hydroxy-2-pyridinealdoxime inside the active-site gorge of AChE was significantly augmented with the addition of neutral peripheral units compared to conventional charged peripheral sites. Oximes 74-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 24312449-9 2013 Docking studies revealed that the poor binding affinity of simple neutral oxime drugs such as 3-hydroxy-2-pyridinealdoxime inside the active-site gorge of AChE was significantly augmented with the addition of neutral peripheral units compared to conventional charged peripheral sites. 3-hydroxy-2-pyridinealdoxime 94-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 23984975-1 2013 The molecular interactions between the enzyme acetylcholinesterase (AChE) and two compound classes consisting of N-[2-(diethylamino)ethyl]benzenesulfonamides and N-[2-(diethylamino)ethyl]benzenemethanesulfonamides have been investigated using organic synthesis, enzymatic assays, X-ray crystallography, and thermodynamic profiling. n-[2-(diethylamino)ethyl]benzenesulfonamides 113-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 23708814-0 2013 Acetylcholinesterase biosensor based on SnO2 nanoparticles-carboxylic graphene-nafion modified electrode for detection of pesticides. carboxylic graphene 59-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 23708814-0 2013 Acetylcholinesterase biosensor based on SnO2 nanoparticles-carboxylic graphene-nafion modified electrode for detection of pesticides. perfluorosulfonic acid 79-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 23708814-1 2013 A sensitive amperometric acetylcholinesterase (AChE) biosensor, based on SnO2 nanoparticles (SnO2 NPs), carboxylic graphene (CGR) and nafion (NF) modified glassy carbon electrode (GCE) for the detection of methyl parathion and carbofuran has been developed. carboxylic graphene 104-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 23708814-1 2013 A sensitive amperometric acetylcholinesterase (AChE) biosensor, based on SnO2 nanoparticles (SnO2 NPs), carboxylic graphene (CGR) and nafion (NF) modified glassy carbon electrode (GCE) for the detection of methyl parathion and carbofuran has been developed. perfluorosulfonic acid 134-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 23708814-1 2013 A sensitive amperometric acetylcholinesterase (AChE) biosensor, based on SnO2 nanoparticles (SnO2 NPs), carboxylic graphene (CGR) and nafion (NF) modified glassy carbon electrode (GCE) for the detection of methyl parathion and carbofuran has been developed. perfluorosulfonic acid 134-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 23708814-1 2013 A sensitive amperometric acetylcholinesterase (AChE) biosensor, based on SnO2 nanoparticles (SnO2 NPs), carboxylic graphene (CGR) and nafion (NF) modified glassy carbon electrode (GCE) for the detection of methyl parathion and carbofuran has been developed. Carbon 162-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 24097403-1 2013 RATIONALE: 2-arylidene-4-methoxy (or hydroxy)-7-methyl-1-indanone derivatives inspired from donepezil, the current drug used for the treatment of Alzheimer"s disease as inhibitor of acetylcholinesterase (AChE), were studied for the first time by electrospray ionization mass spectrometry (ESI-MS) and tandem mass spectrometry (MS/MS). 2-arylidene-4-methoxy (or hydroxy)-7-methyl-1-indanone 11-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-208 24097403-1 2013 RATIONALE: 2-arylidene-4-methoxy (or hydroxy)-7-methyl-1-indanone derivatives inspired from donepezil, the current drug used for the treatment of Alzheimer"s disease as inhibitor of acetylcholinesterase (AChE), were studied for the first time by electrospray ionization mass spectrometry (ESI-MS) and tandem mass spectrometry (MS/MS). Donepezil 92-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-202 24097403-1 2013 RATIONALE: 2-arylidene-4-methoxy (or hydroxy)-7-methyl-1-indanone derivatives inspired from donepezil, the current drug used for the treatment of Alzheimer"s disease as inhibitor of acetylcholinesterase (AChE), were studied for the first time by electrospray ionization mass spectrometry (ESI-MS) and tandem mass spectrometry (MS/MS). Donepezil 92-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-208 24084001-3 2013 Then, acetylcholinesterase (AChE) was adsorbed onto the GO/Fe3O4 surface to form GO/Fe3O4/AChE MNCs which was locally packed into PDMS microchannel simply with the help of external magnetic field to form an on-chip enzymatic microreactor. ferryl iron 59-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-26 24084001-3 2013 Then, acetylcholinesterase (AChE) was adsorbed onto the GO/Fe3O4 surface to form GO/Fe3O4/AChE MNCs which was locally packed into PDMS microchannel simply with the help of external magnetic field to form an on-chip enzymatic microreactor. ferryl iron 59-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 24084001-3 2013 Then, acetylcholinesterase (AChE) was adsorbed onto the GO/Fe3O4 surface to form GO/Fe3O4/AChE MNCs which was locally packed into PDMS microchannel simply with the help of external magnetic field to form an on-chip enzymatic microreactor. ferryl iron 59-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 24084001-3 2013 Then, acetylcholinesterase (AChE) was adsorbed onto the GO/Fe3O4 surface to form GO/Fe3O4/AChE MNCs which was locally packed into PDMS microchannel simply with the help of external magnetic field to form an on-chip enzymatic microreactor. ferryl iron 84-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-26 24084001-3 2013 Then, acetylcholinesterase (AChE) was adsorbed onto the GO/Fe3O4 surface to form GO/Fe3O4/AChE MNCs which was locally packed into PDMS microchannel simply with the help of external magnetic field to form an on-chip enzymatic microreactor. ferryl iron 84-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 24084001-4 2013 The constructed GO/Fe3O4/AChE MNCs-based enzymatic microreactor not only have the magnetism of Fe3O4 NPs that make them conveniently manipulated by an external magnetic field, but also have the larger surface and excellent biocompatibility of graphene which can incorporate much more AChE molecules and well maintain their biological activity. ferryl iron 19-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 24084001-4 2013 The constructed GO/Fe3O4/AChE MNCs-based enzymatic microreactor not only have the magnetism of Fe3O4 NPs that make them conveniently manipulated by an external magnetic field, but also have the larger surface and excellent biocompatibility of graphene which can incorporate much more AChE molecules and well maintain their biological activity. ferryl iron 19-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 284-288 24084001-4 2013 The constructed GO/Fe3O4/AChE MNCs-based enzymatic microreactor not only have the magnetism of Fe3O4 NPs that make them conveniently manipulated by an external magnetic field, but also have the larger surface and excellent biocompatibility of graphene which can incorporate much more AChE molecules and well maintain their biological activity. ferryl iron 95-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 24084001-4 2013 The constructed GO/Fe3O4/AChE MNCs-based enzymatic microreactor not only have the magnetism of Fe3O4 NPs that make them conveniently manipulated by an external magnetic field, but also have the larger surface and excellent biocompatibility of graphene which can incorporate much more AChE molecules and well maintain their biological activity. Graphite 243-251 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 24084001-5 2013 On the basis of the AChE inhibition principle, a novel on-chip enzymatic microreactor was constructed for analyzing dimethoate which is usually used as a model of organophosphorus pesticides. Dimethoate 116-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 24084001-5 2013 On the basis of the AChE inhibition principle, a novel on-chip enzymatic microreactor was constructed for analyzing dimethoate which is usually used as a model of organophosphorus pesticides. organophosphorus 163-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 24084001-6 2013 Under optimal conditions, a linear relationship between the inhibition rates of AChE and the concentration of dimethoate from 1 to 20 mugL(-1) with a detection limit of 0.18 mugL(-1) (S/N=3) was obtained. Dimethoate 110-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 24591156-7 2013 AChE was effectively inhibited by sulfanomides 13-16, with K(i) values in the range of 33.04 +- 4.3 to 131.68 +- 8.8 nM. sulfanomides 34-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 24591157-0 2013 Design, synthesis, biological evaluation, and molecular modeling of coumarin-piperazine derivatives as acetylcholinesterase inhibitors. coumarin 68-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 24591157-0 2013 Design, synthesis, biological evaluation, and molecular modeling of coumarin-piperazine derivatives as acetylcholinesterase inhibitors. Piperazine 77-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 24591157-2 2013 A novel series of coumarin-piperazine derivatives were synthesized and their potency to inhibit human AChE enzyme (hAChE) was studied. coumarin-piperazine 18-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 24591157-2 2013 A novel series of coumarin-piperazine derivatives were synthesized and their potency to inhibit human AChE enzyme (hAChE) was studied. coumarin-piperazine 18-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-120 24591157-4 2013 Docking experiments of the designed coumarin-piperazine derivatives were carried out in order to compare the theoretical and experimental binding affinities toward hAChE, to delineate the inhibitory mechanism. coumarin 36-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-169 24591157-4 2013 Docking experiments of the designed coumarin-piperazine derivatives were carried out in order to compare the theoretical and experimental binding affinities toward hAChE, to delineate the inhibitory mechanism. Piperazine 45-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-169 24076173-0 2013 Reversible inhibition of human acetylcholinesterase by methoxypyridinium species. methoxypyridinium 55-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 24076173-1 2013 The irreversible inhibition of acetylcholinesterase (AChE) by organophosphorous chemical warfare agents necessitates that antidotes be administered for effective treatment. organophosphorous 62-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 24076173-1 2013 The irreversible inhibition of acetylcholinesterase (AChE) by organophosphorous chemical warfare agents necessitates that antidotes be administered for effective treatment. organophosphorous 62-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 23777789-0 2013 On the behavior of acetylcholinesterase immobilized on carbon nanotubes in the presence of inhibitors. Carbon 55-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 23777789-1 2013 The behavior of acetylcholinesterase before and after click-chemistry reaction on carbon nanotubes was evaluated by kinetic parameters from Michaelis-Menten equation. Carbon 82-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 23777789-5 2013 We were able to demonstrate that this is caused by competition between the MWCNTs and acetylthiocholine for the active sites of AChE. Acetylthiocholine 86-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 24211763-7 2013 Two hours after acute Al exposure AChE activity and SH group content were decreased and MDA and O2(-) levels were elevated in all investigated brain structures. Aluminum 22-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 24215347-2 2013 In the absence of a single drug, the administration of an aminosteroid NMBA, such as rocuronium, followed by reversal using an acetylcholinesterase inhibitor, such as neostigmine, is commonly employed. Neostigmine 167-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 23933009-2 2013 OPs affect neuronal signaling through acetylcholine (Ach) neurotransmission via inhibition of acetylcholinesterase (AChE), leading to accumulation of Ach at the synaptic cleft and excessive stimulation at post-synaptic receptors. Acetylcholine 38-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 23933009-2 2013 OPs affect neuronal signaling through acetylcholine (Ach) neurotransmission via inhibition of acetylcholinesterase (AChE), leading to accumulation of Ach at the synaptic cleft and excessive stimulation at post-synaptic receptors. Acetylcholine 38-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 23933009-2 2013 OPs affect neuronal signaling through acetylcholine (Ach) neurotransmission via inhibition of acetylcholinesterase (AChE), leading to accumulation of Ach at the synaptic cleft and excessive stimulation at post-synaptic receptors. Acetylcholine 53-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 23933009-2 2013 OPs affect neuronal signaling through acetylcholine (Ach) neurotransmission via inhibition of acetylcholinesterase (AChE), leading to accumulation of Ach at the synaptic cleft and excessive stimulation at post-synaptic receptors. Acetylcholine 53-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 23933009-2 2013 OPs affect neuronal signaling through acetylcholine (Ach) neurotransmission via inhibition of acetylcholinesterase (AChE), leading to accumulation of Ach at the synaptic cleft and excessive stimulation at post-synaptic receptors. Acetylcholine 150-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 23933009-2 2013 OPs affect neuronal signaling through acetylcholine (Ach) neurotransmission via inhibition of acetylcholinesterase (AChE), leading to accumulation of Ach at the synaptic cleft and excessive stimulation at post-synaptic receptors. Acetylcholine 150-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 23973658-0 2013 Synthesis and acetylcholinesterase inhibitory activity of polyhydroxylated sulfated steroids: structure/activity studies. polyhydroxylated sulfated steroids 58-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 23973658-1 2013 Disulfated and trisulfated steroids have been synthesized from cholesterol and their acetylcholinesterase inhibitory activity has been evaluated. disulfated 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 23973658-1 2013 Disulfated and trisulfated steroids have been synthesized from cholesterol and their acetylcholinesterase inhibitory activity has been evaluated. trisulfated steroids 15-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 25490843-1 2013 The paper is a review of literature data on interaction of the mammalian erythrocyte acetylcholinesterase and blood serum butyrylcholinesterase with a group of isomer complex ester derivatives (acetates, propionates, butyrates, valerates, and isobutyrates) of bases and iodomethylates of ephedrine and its enantiomer pseudoephedrine. Acetates 194-202 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 25490843-1 2013 The paper is a review of literature data on interaction of the mammalian erythrocyte acetylcholinesterase and blood serum butyrylcholinesterase with a group of isomer complex ester derivatives (acetates, propionates, butyrates, valerates, and isobutyrates) of bases and iodomethylates of ephedrine and its enantiomer pseudoephedrine. Butyrates 217-226 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 25490843-1 2013 The paper is a review of literature data on interaction of the mammalian erythrocyte acetylcholinesterase and blood serum butyrylcholinesterase with a group of isomer complex ester derivatives (acetates, propionates, butyrates, valerates, and isobutyrates) of bases and iodomethylates of ephedrine and its enantiomer pseudoephedrine. Ephedrine 288-297 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 25490843-1 2013 The paper is a review of literature data on interaction of the mammalian erythrocyte acetylcholinesterase and blood serum butyrylcholinesterase with a group of isomer complex ester derivatives (acetates, propionates, butyrates, valerates, and isobutyrates) of bases and iodomethylates of ephedrine and its enantiomer pseudoephedrine. Pseudoephedrine 317-332 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 25490843-3 2013 The studied 20 aklaloid diesters and 10 trimethylammonium derivatives turned out to be non-competitive reversible inhibitors of acetylcholinesterase and competitive inhibitors of butyrylcholinesterase. Cetrimonium 40-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 24040835-0 2013 The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity. dhts 20-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 24040835-1 2013 Cholinergic synaptic transmission often requires extremely rapid hydrolysis of acetylcholine by acetylcholinesterase (AChE). Acetylcholine 79-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 24040835-1 2013 Cholinergic synaptic transmission often requires extremely rapid hydrolysis of acetylcholine by acetylcholinesterase (AChE). Acetylcholine 79-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 24040835-2 2013 AChE is inactivated by organophosphates (OPs) in chemical warfare nerve agents. Organophosphates 23-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 24040835-2 2013 AChE is inactivated by organophosphates (OPs) in chemical warfare nerve agents. Organophosphates 41-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 24040835-4 2013 A potential long-term strategy for preventing AChE inactivation by OPs is based on evidence that OPs must pass through a peripheral site or P-site near the mouth of the AChE active site gorge before reacting with a catalytic serine in an acylation site or A-site at the base of the gorge. Serine 225-231 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 24180424-0 2013 Isoxazoles: synthesis, evaluation and bioinformatic design as acetylcholinesterase inhibitors. Isoxazoles 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 24180424-2 2013 In this study, nine isoxazoles derivatives were tested for their in-vitro AChE activity. Isoxazoles 20-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 24180424-7 2013 KEY FINDINGS: The isoxazoles are described as inhibitors of AChE. Isoxazoles 18-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 24180424-10 2013 CONCLUSIONS: Our research provided enough evidence of the efficacy of isoxazoles as AChE inhibitors. Isoxazoles 70-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 24180424-11 2013 The isoxazoles were synthesized and evaluated as inhibitors of AChE. Isoxazoles 4-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 24180424-12 2013 The docking study based on a novel series of complexes isoxazole with AChE from Electroporus electricus has demonstrated that the ligand bind is similar to the compounds used as reference. Isoxazoles 55-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 24180424-13 2013 To find new candidates with the isoxazole core that act as inhibitors of AChE, part of the structure of the compound 9 was used for de-novo design. Isoxazoles 32-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 24236981-7 2013 Following this view, an increasing interest in achieving more potent and effective analogues makes alkaloids good chemical templates for the development of new cholinesterase inhibitors. Alkaloids 99-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-174 24249815-1 2013 BACKGROUND: Organophosphate exposures can affect children"s neurodevelopment, possibly due to neurotoxicity induced by acetylcholinesterase (AChE) inhibition, and may affect boys more than girls. Organophosphates 12-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 24249815-1 2013 BACKGROUND: Organophosphate exposures can affect children"s neurodevelopment, possibly due to neurotoxicity induced by acetylcholinesterase (AChE) inhibition, and may affect boys more than girls. Organophosphates 12-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 24312390-7 2013 In AD patients (n=28), CSF AChE activity correlated positively with CSF levels of total tau (T-tau) (r = 0.44, P < 0.05) and phosphorylated tau protein (P-tau) (r = 0.50, P < 0.01), but CSF activities of AChE or BuChE did not correlate with serum or CSF levels of 25OHD. 25ohd 264-269 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 24097403-1 2013 RATIONALE: 2-arylidene-4-methoxy (or hydroxy)-7-methyl-1-indanone derivatives inspired from donepezil, the current drug used for the treatment of Alzheimer"s disease as inhibitor of acetylcholinesterase (AChE), were studied for the first time by electrospray ionization mass spectrometry (ESI-MS) and tandem mass spectrometry (MS/MS). 2-arylidene-4-methoxy (or hydroxy)-7-methyl-1-indanone 11-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-202 23711227-1 2013 The main purpose of this study was to evaluate whether donepezil, acetylcholinesterase inhibitor, shown to play a protective role through inhibiting glycogen synthesis kinase-3beta (GSK-3beta) activity, could also exert neuroprotective effects by stimulating protein phosphatase 2A (PP2A) activity in the amyloid-beta (Abeta)42-induced neuronal toxicity model of Alzheimer"s disease. Donepezil 55-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 24475704-3 2013 A Lineweaver-Burk plot and molecular modeling study showed that these derivatives targeted both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. cas 123-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 24475704-3 2013 A Lineweaver-Burk plot and molecular modeling study showed that these derivatives targeted both the catalytic active site (CAS) and the peripheral anionic site (PAS) of AChE. Aminosalicylic Acid 161-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 24020883-1 2013 Considering inter- or intra-individual variation in the normal levels of acetylcholinesterase (AChE), real-time measurement of AChE via the reactivation from a postexposure sample was used, and thus a baseline-free and reliable approach was proposed for detecting/screening low-dose organophosphorus pesticides (OPs) poisons. organophosphorus 283-299 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-93 24020883-1 2013 Considering inter- or intra-individual variation in the normal levels of acetylcholinesterase (AChE), real-time measurement of AChE via the reactivation from a postexposure sample was used, and thus a baseline-free and reliable approach was proposed for detecting/screening low-dose organophosphorus pesticides (OPs) poisons. organophosphorus 283-299 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 24020883-6 2013 Greatly enhanced sensitivity was achieved by using Fe3O4/Au nanocomposites to enrich thiocholine, the hydrolysis product of active AChE, followed by electrochemical oxidative desorption of the adsorbed thiocholine. ferryl iron 51-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 24020883-6 2013 Greatly enhanced sensitivity was achieved by using Fe3O4/Au nanocomposites to enrich thiocholine, the hydrolysis product of active AChE, followed by electrochemical oxidative desorption of the adsorbed thiocholine. Gold 57-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 24020883-6 2013 Greatly enhanced sensitivity was achieved by using Fe3O4/Au nanocomposites to enrich thiocholine, the hydrolysis product of active AChE, followed by electrochemical oxidative desorption of the adsorbed thiocholine. Thiocholine 85-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 23984975-1 2013 The molecular interactions between the enzyme acetylcholinesterase (AChE) and two compound classes consisting of N-[2-(diethylamino)ethyl]benzenesulfonamides and N-[2-(diethylamino)ethyl]benzenemethanesulfonamides have been investigated using organic synthesis, enzymatic assays, X-ray crystallography, and thermodynamic profiling. n-[2-(diethylamino)ethyl]benzenesulfonamides 113-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 23984975-1 2013 The molecular interactions between the enzyme acetylcholinesterase (AChE) and two compound classes consisting of N-[2-(diethylamino)ethyl]benzenesulfonamides and N-[2-(diethylamino)ethyl]benzenemethanesulfonamides have been investigated using organic synthesis, enzymatic assays, X-ray crystallography, and thermodynamic profiling. n-[2-(diethylamino)ethyl]benzenemethanesulfonamides 162-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 23984975-1 2013 The molecular interactions between the enzyme acetylcholinesterase (AChE) and two compound classes consisting of N-[2-(diethylamino)ethyl]benzenesulfonamides and N-[2-(diethylamino)ethyl]benzenemethanesulfonamides have been investigated using organic synthesis, enzymatic assays, X-ray crystallography, and thermodynamic profiling. n-[2-(diethylamino)ethyl]benzenemethanesulfonamides 162-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-72 23984975-2 2013 The inhibitors" aromatic properties were varied to establish structure-activity relationships (SAR) between the inhibitors and the peripheral anionic site (PAS) of AChE. Aminosalicylic Acid 156-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 23988409-0 2013 Design, synthesis, biological evaluation and docking study of 5-oxo-4,5-dihydropyrano[3,2-c]chromene derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors. 5-oxo-4,5-dihydropyrano[3,2-c]chromene 62-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 24900626-2 2013 In order to identify novel Alzheimer"s modifying pharmacological tools, we developed bis-tacrines bearing a peptide moiety for specific interference with surface sites of human acetylcholinesterase (hAChE) binding amyloid-beta (Abeta). bis-tacrines 85-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-197 24900626-2 2013 In order to identify novel Alzheimer"s modifying pharmacological tools, we developed bis-tacrines bearing a peptide moiety for specific interference with surface sites of human acetylcholinesterase (hAChE) binding amyloid-beta (Abeta). bis-tacrines 85-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-204 24900626-2 2013 In order to identify novel Alzheimer"s modifying pharmacological tools, we developed bis-tacrines bearing a peptide moiety for specific interference with surface sites of human acetylcholinesterase (hAChE) binding amyloid-beta (Abeta). UNII-042A8N37WH 228-233 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-197 24900626-2 2013 In order to identify novel Alzheimer"s modifying pharmacological tools, we developed bis-tacrines bearing a peptide moiety for specific interference with surface sites of human acetylcholinesterase (hAChE) binding amyloid-beta (Abeta). UNII-042A8N37WH 228-233 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-204 23826635-3 2013 In this study, bis(propyl)-cognitin (B3C), a novel dimer that possesses anti-AChE and anti-N-methyl-d-aspartate receptor activities, was investigated for its neuroprotective effect on K(+) deprivation-induced apoptosis in cerebellar granule neurons (CGNs). bis(propyl)cognitin 15-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 23988409-1 2013 A series of fused coumarins namely 5-oxo-4,5-dihydropyrano[3,2-c]chromenes linked to N-benzylpyridinium scaffold were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. Coumarins 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 23988409-1 2013 A series of fused coumarins namely 5-oxo-4,5-dihydropyrano[3,2-c]chromenes linked to N-benzylpyridinium scaffold were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. Coumarins 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 23988409-1 2013 A series of fused coumarins namely 5-oxo-4,5-dihydropyrano[3,2-c]chromenes linked to N-benzylpyridinium scaffold were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. 5-oxo-4,5-dihydropyrano[3,2-c]chromenes 35-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 23988409-1 2013 A series of fused coumarins namely 5-oxo-4,5-dihydropyrano[3,2-c]chromenes linked to N-benzylpyridinium scaffold were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. 5-oxo-4,5-dihydropyrano[3,2-c]chromenes 35-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 23988409-2 2013 The 1-(4-fluorobenzyl)pyridinium derivative 6g showed the most potent anti-AChE activity (IC50 value=0.038 muM) and the highest AChE/BuChE selectivity (SI>48). Pyridinium, 1-[(4-fluorophenyl)methyl]- 4-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 23988409-2 2013 The 1-(4-fluorobenzyl)pyridinium derivative 6g showed the most potent anti-AChE activity (IC50 value=0.038 muM) and the highest AChE/BuChE selectivity (SI>48). Pyridinium, 1-[(4-fluorophenyl)methyl]- 4-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 23988410-1 2013 We recently discovered and reported dual inhibitor 5 of AChE and BACE1 with N-benzylpiperidine ethyl as C-terminus. n-benzylpiperidine ethyl 76-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 23988412-1 2013 Novel hybrid derivatives of two known scaffolds; tetrahydroaminoquinoline and coumarin were synthesized and evaluated for both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities. coumarin 78-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-147 24020636-0 2013 Analysis of the activation of acetylcholinesterase by carbon nanoparticles using a monolithic immobilized enzyme microreactor: role of the water molecules in the active site gorge. Carbon 54-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 24379961-0 2013 Synthesis and Evaluation of Anti-acetylcholinesterase Activity of 2-(2-(4-(2-Oxo-2-phenylethyl)piperazin-1-yl) ethyl)Isoindoline-1,3-dione Derivatives with Potential Anti-Alzheimer Effects. 2-(2-(4-(2-oxo-2-phenylethyl)piperazin-1-yl) ethyl)isoindoline-1,3-dione 66-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 24379961-4 2013 Acetylcholinesterase inhibitors such as donepezil can enhance the duration of action of acetylcholine (Ach) and therefore, through this mechanism improve the symptoms of AD. Donepezil 40-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24379961-4 2013 Acetylcholinesterase inhibitors such as donepezil can enhance the duration of action of acetylcholine (Ach) and therefore, through this mechanism improve the symptoms of AD. Acetylcholine 88-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24379961-4 2013 Acetylcholinesterase inhibitors such as donepezil can enhance the duration of action of acetylcholine (Ach) and therefore, through this mechanism improve the symptoms of AD. Acetylcholine 103-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24379961-5 2013 MATERIALS AND METHODS: In the current study, based on the potential inhibitory activity of phthalimide derivatives towards acetylcholinesterase enzyme, a new series of phthalimide-based compounds were synthesized (4a-4e) and anti-acetylcholinesterase effect was assessed using Ellman"s test. phthalimide 91-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-143 24379961-5 2013 MATERIALS AND METHODS: In the current study, based on the potential inhibitory activity of phthalimide derivatives towards acetylcholinesterase enzyme, a new series of phthalimide-based compounds were synthesized (4a-4e) and anti-acetylcholinesterase effect was assessed using Ellman"s test. phthalimide 91-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 230-250 24379961-5 2013 MATERIALS AND METHODS: In the current study, based on the potential inhibitory activity of phthalimide derivatives towards acetylcholinesterase enzyme, a new series of phthalimide-based compounds were synthesized (4a-4e) and anti-acetylcholinesterase effect was assessed using Ellman"s test. phthalimide 168-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-143 24379961-5 2013 MATERIALS AND METHODS: In the current study, based on the potential inhibitory activity of phthalimide derivatives towards acetylcholinesterase enzyme, a new series of phthalimide-based compounds were synthesized (4a-4e) and anti-acetylcholinesterase effect was assessed using Ellman"s test. phthalimide 168-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 230-250 24379961-8 2013 CONCLUSION: The new synthesized phthalimide based analogs could function as potential acetylcholinesterase inhibitors. phthalimide 32-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 22871134-0 2013 Design, synthesis and evaluation of new thiazole-piperazines as acetylcholinesterase inhibitors. thiazole-piperazines 40-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-84 24020636-0 2013 Analysis of the activation of acetylcholinesterase by carbon nanoparticles using a monolithic immobilized enzyme microreactor: role of the water molecules in the active site gorge. Water 139-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 24020636-1 2013 A biochromatographic system was used to study the direct effect of carbon nanoparticles (CNPs) on the acetylcholinesterase (AChE) activity. Carbon 67-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 24020636-1 2013 A biochromatographic system was used to study the direct effect of carbon nanoparticles (CNPs) on the acetylcholinesterase (AChE) activity. Carbon 67-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 24020636-2 2013 The AChE enzyme was covalently immobilized on a monolithic CIM-disk via its NH2 residues. cim 59-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 23948665-15 2013 Both an acetylcholinesterase inhibitor (eserine) and a butyrylcholinesterase inhibitor (ethopropazine) increased cell proliferation, and these effects were inhibited by 4-DAMP, a mAChR3 antagonist. 4-diphenylacetoxy-1,1-dimethylpiperidinium 169-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-28 23747570-4 2013 Furthermore, elevating extracellular ACh with the acetylcholinesterase inhibitor physostigmine had a larger effect on depolarizing versus hyperpolarizing responses. Acetylcholine 37-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 23747570-4 2013 Furthermore, elevating extracellular ACh with the acetylcholinesterase inhibitor physostigmine had a larger effect on depolarizing versus hyperpolarizing responses. Physostigmine 81-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 23957453-3 2013 The inhibitory activities of these isolates on acetylcholinesterase and five human tumor cell lines were tested, and hypercohins B-D (1-3) exhibited moderate inhibitory activity (IC50 5.8-17.9 muM) against the tested tumor cell lines. hypercohins b-d 117-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 24016585-4 2013 This system was validated by measuring dose-response curves of three types of acetylcholinesterase (AChE) inhibitors, including carbamate pesticide, organophosphorus pesticide, and therapeutic drugs regulating Alzheimer"s disease. Carbamates 128-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 24016585-4 2013 This system was validated by measuring dose-response curves of three types of acetylcholinesterase (AChE) inhibitors, including carbamate pesticide, organophosphorus pesticide, and therapeutic drugs regulating Alzheimer"s disease. Carbamates 128-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 24016585-4 2013 This system was validated by measuring dose-response curves of three types of acetylcholinesterase (AChE) inhibitors, including carbamate pesticide, organophosphorus pesticide, and therapeutic drugs regulating Alzheimer"s disease. organophosphorus 149-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 24016585-4 2013 This system was validated by measuring dose-response curves of three types of acetylcholinesterase (AChE) inhibitors, including carbamate pesticide, organophosphorus pesticide, and therapeutic drugs regulating Alzheimer"s disease. organophosphorus 149-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 24900610-0 2013 Structures of human acetylcholinesterase bound to dihydrotanshinone I and territrem B show peripheral site flexibility. dhts 50-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 24900610-1 2013 Acetylcholinesterase is a critical enzyme that regulates neurotransmission by degrading the neurotransmitter acetylcholine in synapses of the nervous system. Acetylcholine 109-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24900610-4 2013 Structures of recombinant human acetylcholinesterase in complex with the natural product inhibitors dihydrotanshinone I and territrem B reveal dihydrotanshinone I binding that is specific to only the peripheral site and territrem B binding that spans both sites and distorts the protein backbone in the peripheral site. DIHYDROTANSHINONE 100-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 24900610-4 2013 Structures of recombinant human acetylcholinesterase in complex with the natural product inhibitors dihydrotanshinone I and territrem B reveal dihydrotanshinone I binding that is specific to only the peripheral site and territrem B binding that spans both sites and distorts the protein backbone in the peripheral site. dhts 100-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 23885349-0 2013 Nanoparticle-based immunochromatographic test strip with fluorescent detector for quantification of phosphorylated acetylcholinesterase: an exposure biomarker of organophosphorus agents. organophosphorus 162-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 23885349-1 2013 A nanoparticle-based fluorescence immunochromatographic test strip (FITS) coupled with a hand-held detector for highly selective and sensitive detection of phosphorylated acetylcholinesterase (AChE), an exposure biomarker of organophosphate (OP) pesticides and nerve agents, is reported. Organophosphates 225-240 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-191 23885349-1 2013 A nanoparticle-based fluorescence immunochromatographic test strip (FITS) coupled with a hand-held detector for highly selective and sensitive detection of phosphorylated acetylcholinesterase (AChE), an exposure biomarker of organophosphate (OP) pesticides and nerve agents, is reported. Organophosphates 225-240 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-197 23932451-2 2013 Among these hybrids, compounds 4f and 4i, berberine linked with o-methylthiophenyl and o-chlorothiophenyl by a 2-carbon spacer, were observed to be potent inhibitors of AChE, with IC50 values of 0.077 and 0.042 muM, respectively. Berberine 42-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 24081314-2 2013 The acetylcholinesterase inhibitors donepezil, rivastigmine, and galantamine and the NMDA-receptor antagonist memantine have produced modest but apparently persistent improvements in cognition, activities of daily living, and behavior in patients with disease severity ranging from mild to severe. Donepezil 36-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 24081314-2 2013 The acetylcholinesterase inhibitors donepezil, rivastigmine, and galantamine and the NMDA-receptor antagonist memantine have produced modest but apparently persistent improvements in cognition, activities of daily living, and behavior in patients with disease severity ranging from mild to severe. Rivastigmine 47-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 24081314-2 2013 The acetylcholinesterase inhibitors donepezil, rivastigmine, and galantamine and the NMDA-receptor antagonist memantine have produced modest but apparently persistent improvements in cognition, activities of daily living, and behavior in patients with disease severity ranging from mild to severe. Galantamine 65-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 24081314-3 2013 Among the acetylcholinesterase inhibitors, transdermal rivastigmine causes fewer gastrointestinal side effects than the oral formulation. Rivastigmine 55-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 10-30 24081314-4 2013 Whether adding memantine to an acetylcholinesterase inhibitor is more effective than an acetylcholinesterase inhibitor alone remains to be established; clinical trial results have been mixed. Memantine 15-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 23603132-0 2013 A fluorometric assay for acetylcholinesterase activity and inhibitor detection based on DNA-templated copper/silver nanoclusters. Copper 102-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 23603132-1 2013 A novel label-free, rapid, cost-effective, and highly sensitive fluorometric sensor has been constructed for the detection of acetylcholinesterase (AChE) activity and its inhibitor based on the fluorescence quenching of DNA-templated copper/silver nanoclusters (DNA-Cu/AgNCs). Copper 234-240 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 23603132-1 2013 A novel label-free, rapid, cost-effective, and highly sensitive fluorometric sensor has been constructed for the detection of acetylcholinesterase (AChE) activity and its inhibitor based on the fluorescence quenching of DNA-templated copper/silver nanoclusters (DNA-Cu/AgNCs). Copper 234-240 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 23603132-2 2013 In this assay, AChE catalyzes the hydrolysis of acetylthiocholine (ATCh) to form thiocholine which induces fluorescence quenching of DNA-Cu/AgNCs. Acetylthiocholine 48-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 23603132-2 2013 In this assay, AChE catalyzes the hydrolysis of acetylthiocholine (ATCh) to form thiocholine which induces fluorescence quenching of DNA-Cu/AgNCs. Acetylthiocholine 67-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 23603132-2 2013 In this assay, AChE catalyzes the hydrolysis of acetylthiocholine (ATCh) to form thiocholine which induces fluorescence quenching of DNA-Cu/AgNCs. Thiocholine 54-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 23612061-1 2013 In this paper, we have developed a simple, fast, convenient and sensitive method for determination of organophosphorus pesticides in real samples based on inhibition mechanism of acetylcholinesterase (AChE). organophosphorus 102-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 179-199 23612061-1 2013 In this paper, we have developed a simple, fast, convenient and sensitive method for determination of organophosphorus pesticides in real samples based on inhibition mechanism of acetylcholinesterase (AChE). organophosphorus 102-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 201-205 23932451-2 2013 Among these hybrids, compounds 4f and 4i, berberine linked with o-methylthiophenyl and o-chlorothiophenyl by a 2-carbon spacer, were observed to be potent inhibitors of AChE, with IC50 values of 0.077 and 0.042 muM, respectively. Carbon 113-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 23932451-4 2013 Kinetic studies and molecular modelling simulations of the AChE-inhibitor complex indicated that a mixed-competitive binding mode existed for these berberine derivatives. Berberine 148-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 23708635-0 2013 Development of a biosensor based on immobilization of acetylcholinesterase on NiO nanoparticles-carboxylic graphene-nafion modified electrode for detection of pesticides. Graphite 107-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 23708635-0 2013 Development of a biosensor based on immobilization of acetylcholinesterase on NiO nanoparticles-carboxylic graphene-nafion modified electrode for detection of pesticides. perfluorosulfonic acid 116-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-74 23708635-1 2013 A sensitive amperometric acetylcholinesterase (AChE) biosensor based on NiO nanoparticles (NiO NPs), carboxylic graphene (CGR) and nafion (NF) modified glassy carbon electrode (GCE) has been developed. carboxylic graphene 101-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 23708635-1 2013 A sensitive amperometric acetylcholinesterase (AChE) biosensor based on NiO nanoparticles (NiO NPs), carboxylic graphene (CGR) and nafion (NF) modified glassy carbon electrode (GCE) has been developed. perfluorosulfonic acid 131-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 23708635-1 2013 A sensitive amperometric acetylcholinesterase (AChE) biosensor based on NiO nanoparticles (NiO NPs), carboxylic graphene (CGR) and nafion (NF) modified glassy carbon electrode (GCE) has been developed. perfluorosulfonic acid 131-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 23708635-1 2013 A sensitive amperometric acetylcholinesterase (AChE) biosensor based on NiO nanoparticles (NiO NPs), carboxylic graphene (CGR) and nafion (NF) modified glassy carbon electrode (GCE) has been developed. Carbon 159-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 23708635-1 2013 A sensitive amperometric acetylcholinesterase (AChE) biosensor based on NiO nanoparticles (NiO NPs), carboxylic graphene (CGR) and nafion (NF) modified glassy carbon electrode (GCE) has been developed. Carbon 159-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 23735753-9 2013 On the other hand pralidoxime, an oxime, reactivating acetylcholinesterase (AChE) after organophosphate poisoning, induced population spike recovery after DFP exposure in the presence of bradykinin and Lys-des-Arg(9)-bradykinin. pralidoxime 18-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 23735753-9 2013 On the other hand pralidoxime, an oxime, reactivating acetylcholinesterase (AChE) after organophosphate poisoning, induced population spike recovery after DFP exposure in the presence of bradykinin and Lys-des-Arg(9)-bradykinin. Oximes 24-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 23735753-9 2013 On the other hand pralidoxime, an oxime, reactivating acetylcholinesterase (AChE) after organophosphate poisoning, induced population spike recovery after DFP exposure in the presence of bradykinin and Lys-des-Arg(9)-bradykinin. Organophosphates 88-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 23735753-9 2013 On the other hand pralidoxime, an oxime, reactivating acetylcholinesterase (AChE) after organophosphate poisoning, induced population spike recovery after DFP exposure in the presence of bradykinin and Lys-des-Arg(9)-bradykinin. lys-des-arg 202-213 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 23919577-2 2013 The detection mechanism is based on the concept, that is, AChE hydrolyzes the acetylthiocholine (ATCh) chloride to produce thiocholine (TCh). acetylthiocholine (atch) chloride 78-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 23919577-2 2013 The detection mechanism is based on the concept, that is, AChE hydrolyzes the acetylthiocholine (ATCh) chloride to produce thiocholine (TCh). Thiocholine 84-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 23919577-2 2013 The detection mechanism is based on the concept, that is, AChE hydrolyzes the acetylthiocholine (ATCh) chloride to produce thiocholine (TCh). Thiocholine 98-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 23919577-5 2013 Due to the sensitive and rapid fluorescence turn-on response of dC12-Ag NCs to TCh, AChE with activity as low as 0.5 x 10(-4) U/mL (signal/noise = 3) can be analyzed with a dynamic range of 0.1 to 1.25 x 10(-3) U/mL. Thiocholine 79-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 23789829-0 2013 In silico pharmacophore modeling on known pyridinium oxime reactivators of cyclosarin (GF) inhibited AChE to Aid discovery of potential, more efficacious novel non-oxime reactivators. pyridinium oxime 42-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 23891231-0 2013 Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors. benzimidazole 65-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-117 23789829-0 2013 In silico pharmacophore modeling on known pyridinium oxime reactivators of cyclosarin (GF) inhibited AChE to Aid discovery of potential, more efficacious novel non-oxime reactivators. cyclohexyl methylphosphonofluoridate 75-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 23789829-0 2013 In silico pharmacophore modeling on known pyridinium oxime reactivators of cyclosarin (GF) inhibited AChE to Aid discovery of potential, more efficacious novel non-oxime reactivators. glycylphenylalanine 87-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 23789829-0 2013 In silico pharmacophore modeling on known pyridinium oxime reactivators of cyclosarin (GF) inhibited AChE to Aid discovery of potential, more efficacious novel non-oxime reactivators. Oximes 53-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 23789829-3 2013 The model was generated from published experimental percentage reactivation data on oximes as changes of AChE/BuChE activities in the whole blood after cyclosarin intoxication and administration. Oximes 84-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 23789829-3 2013 The model was generated from published experimental percentage reactivation data on oximes as changes of AChE/BuChE activities in the whole blood after cyclosarin intoxication and administration. cyclohexyl methylphosphonofluoridate 152-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 23789829-6 2013 Furthermore, from virtual screening of two commercial databases, Maybridge and ChemNavigator using map-fitting of the model led us to identify two new non-oxime compounds showing reactivation efficacy within 10-fold range of 2-PAM for DFP-inhibited AChE. Oximes 155-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 249-253 23789829-6 2013 Furthermore, from virtual screening of two commercial databases, Maybridge and ChemNavigator using map-fitting of the model led us to identify two new non-oxime compounds showing reactivation efficacy within 10-fold range of 2-PAM for DFP-inhibited AChE. pralidoxime 225-230 acetylcholinesterase (Cartwright blood group) Homo sapiens 249-253 23838422-0 2013 Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: new dual AChE inhibitors as potential drugs for the treatment of Alzheimer"s disease. 6-chloro-pyridonepezil 65-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 24040835-8 2013 We have used this assay to examine three uncharged, natural product inhibitors of AChE, including aflatoxin B1, dihydrotanshinone I, and territrem B. Aflatoxin B1 98-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 23838422-4 2013 6-Chloro-pyridonepezils4, 7 and 8 are potent hAChE inhibitors showing IC50 in the 0.013-0.054 muM range. 6-chloro-pyridonepezils4 0-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-50 23838422-5 2013 Particularly, 6-chloro-pyridonepezil8 is 625-fold more selective for hAChE than for hBuChE and compared to donepezil is equipotent for the inhibition of hAChE. 6-chloro-pyridonepezil8 14-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-74 23838422-5 2013 Particularly, 6-chloro-pyridonepezil8 is 625-fold more selective for hAChE than for hBuChE and compared to donepezil is equipotent for the inhibition of hAChE. 6-chloro-pyridonepezil8 14-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-158 23838422-5 2013 Particularly, 6-chloro-pyridonepezil8 is 625-fold more selective for hAChE than for hBuChE and compared to donepezil is equipotent for the inhibition of hAChE. Donepezil 27-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-74 23838422-5 2013 Particularly, 6-chloro-pyridonepezil8 is 625-fold more selective for hAChE than for hBuChE and compared to donepezil is equipotent for the inhibition of hAChE. Donepezil 27-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-158 23838422-6 2013 Molecular modeling investigation on 6-chloro-pyridonepezils4, 6-8 supports its dual AChE inhibitory profile, by binding simultaneously at the catalytic active and at peripheral anionic sites of the enzyme. 6-chloro-pyridonepezils4 36-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 23975732-6 2013 infusion of saline and the other during an infusion of the acetylcholinesterase inhibitor physostigmine. Physostigmine 90-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 23747845-2 2013 The catalytic serine of AChE can be phosphonylated by the nerve agent soman, and subsequently can undergo an aging process. Serine 14-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 23829431-4 2013 As the GOx-biocatalyzed oxidation of glucose yields H2O2, and the AChE/ChOx cascade leads to the formation of H2O2, the two biocatalytic processes could be probed by the cysteine-stimulated aggregation of the Au NPs. Glucose 37-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 23829431-4 2013 As the GOx-biocatalyzed oxidation of glucose yields H2O2, and the AChE/ChOx cascade leads to the formation of H2O2, the two biocatalytic processes could be probed by the cysteine-stimulated aggregation of the Au NPs. chox 71-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 23829431-4 2013 As the GOx-biocatalyzed oxidation of glucose yields H2O2, and the AChE/ChOx cascade leads to the formation of H2O2, the two biocatalytic processes could be probed by the cysteine-stimulated aggregation of the Au NPs. Hydrogen Peroxide 110-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 23829431-4 2013 As the GOx-biocatalyzed oxidation of glucose yields H2O2, and the AChE/ChOx cascade leads to the formation of H2O2, the two biocatalytic processes could be probed by the cysteine-stimulated aggregation of the Au NPs. Cysteine 170-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 23829431-5 2013 Since AChE is inhibited by 1,5-bis(4-allyldimethylammonium phenyl)pentane-3-one dibromide, the biocatalytic AChE/ChOx cascade is inhibited by the inhibitor, thus leading to the enhanced cysteine-mediated aggregation of the NPs. 1,5-bis(4-allyldimethylammonium phenyl)pentane-3-one dibromide 27-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 23829431-5 2013 Since AChE is inhibited by 1,5-bis(4-allyldimethylammonium phenyl)pentane-3-one dibromide, the biocatalytic AChE/ChOx cascade is inhibited by the inhibitor, thus leading to the enhanced cysteine-mediated aggregation of the NPs. 1,5-bis(4-allyldimethylammonium phenyl)pentane-3-one dibromide 27-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 23829431-5 2013 Since AChE is inhibited by 1,5-bis(4-allyldimethylammonium phenyl)pentane-3-one dibromide, the biocatalytic AChE/ChOx cascade is inhibited by the inhibitor, thus leading to the enhanced cysteine-mediated aggregation of the NPs. chox 113-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 23829431-5 2013 Since AChE is inhibited by 1,5-bis(4-allyldimethylammonium phenyl)pentane-3-one dibromide, the biocatalytic AChE/ChOx cascade is inhibited by the inhibitor, thus leading to the enhanced cysteine-mediated aggregation of the NPs. chox 113-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 23829431-5 2013 Since AChE is inhibited by 1,5-bis(4-allyldimethylammonium phenyl)pentane-3-one dibromide, the biocatalytic AChE/ChOx cascade is inhibited by the inhibitor, thus leading to the enhanced cysteine-mediated aggregation of the NPs. Cysteine 186-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 23829431-5 2013 Since AChE is inhibited by 1,5-bis(4-allyldimethylammonium phenyl)pentane-3-one dibromide, the biocatalytic AChE/ChOx cascade is inhibited by the inhibitor, thus leading to the enhanced cysteine-mediated aggregation of the NPs. Cysteine 186-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 23829431-6 2013 The results suggest the potential implementation of the cysteine-mediated aggregation of Au NPs in the presence of AChE/ChOx as a sensing platform for the optical detection of chemical warfare agents. Cysteine 56-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 23747845-6 2013 The role of pre-protonation and electrostatic stabilization by histidine (His440(+)) in catalyzing the aging process of soman inhibited AChE is energetically comparable. Histidine 63-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140 23777291-9 2013 Finally, molecular docking of these novel molecules into the AChE binding domain indicated that three molecules (6c, 7c, and 7h) should have significantly higher affinities and solvation energies than the known standard drug donepezil. Donepezil 225-234 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 23941108-6 2013 Among the compounds reported, casuarinine H (8) exhibited significant neuroprotective effect against hydrogen peroxide (H2O2)-induced neuronal cell damage in human neuroblastoma SH-SY5Y cells, while casuarinines C (3) and I (9) showed moderate inhibitory activity against acetylcholinesterase (AChE). casuarinine H 30-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 272-292 23777291-10 2013 The docking studies of 2H-thiazolo[3,2-a]pyrimidines (6a-6j) and 5H-thiazolo[3,2-a] pyrimidines (7a-7j) with human AChE have demonstrated that these ligands bind to the dual sites of the enzyme. 2h-thiazolo[3,2-a]pyrimidines 23-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 23777291-10 2013 The docking studies of 2H-thiazolo[3,2-a]pyrimidines (6a-6j) and 5H-thiazolo[3,2-a] pyrimidines (7a-7j) with human AChE have demonstrated that these ligands bind to the dual sites of the enzyme. 5h-thiazolo[3,2-a] pyrimidines 65-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 23941108-6 2013 Among the compounds reported, casuarinine H (8) exhibited significant neuroprotective effect against hydrogen peroxide (H2O2)-induced neuronal cell damage in human neuroblastoma SH-SY5Y cells, while casuarinines C (3) and I (9) showed moderate inhibitory activity against acetylcholinesterase (AChE). casuarinine H 30-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 294-298 23917882-0 2013 Acetylcholinesterase reactivators (HI-6, obidoxime, trimedoxime, K027, K075, K127, K203, K282): structural evaluation of human serum albumin binding and absorption kinetics. asoxime chloride 35-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 23999806-1 2013 The enzyme acetylcholinesterase (AChE) is an important part of cholinergic nervous system, where it stops neurotransmission by hydrolysis of the neurotransmitter acetylcholine. Acetylcholine 11-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 23959117-0 2013 Oximes: inhibitors of human recombinant acetylcholinesterase. Oximes 0-6 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 23959117-2 2013 Acetylcholinesterase (AChE) reactivators were developed for the treatment of organophosphate intoxication. Organophosphates 77-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 23959117-2 2013 Acetylcholinesterase (AChE) reactivators were developed for the treatment of organophosphate intoxication. Organophosphates 77-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 23959117-3 2013 Standard care involves the use of anticonvulsants (e.g., diazepam), parasympatolytics (e.g., atropine) and oximes that restore AChE activity. Atropine 93-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 23959117-3 2013 Standard care involves the use of anticonvulsants (e.g., diazepam), parasympatolytics (e.g., atropine) and oximes that restore AChE activity. Oximes 107-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 23959117-4 2013 However, oximes also bind to the active site of AChE, simultaneously acting as reversible inhibitors. Oximes 9-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 23959117-5 2013 The goal of the present study is to determine how oxime structure influences the inhibition of human recombinant AChE (hrAChE). Oximes 50-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 23917882-0 2013 Acetylcholinesterase reactivators (HI-6, obidoxime, trimedoxime, K027, K075, K127, K203, K282): structural evaluation of human serum albumin binding and absorption kinetics. Obidoxime Chloride 41-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 23917882-0 2013 Acetylcholinesterase reactivators (HI-6, obidoxime, trimedoxime, K027, K075, K127, K203, K282): structural evaluation of human serum albumin binding and absorption kinetics. Trimedoxime 52-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 23679855-3 2013 To aid in the design of these MTDLs, we report the crystal structures of hAChE (human acetylcholinesterase) in complex with FAS-2 (fasciculin 2) and a hydroxylated derivative of huprine (huprine W), and of hBChE (human butyrylcholinesterase) in complex with tacrine. huprine 178-185 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-78 23881696-0 2013 Synthesis and biological evaluation of a series of dithiocarbamates as new cholinesterase inhibitors. dithiocarbamates 51-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-89 23881696-4 2013 The most potent AChE inhibitor was found as compound 2g (IC50 = 0.53 +- 0.001 microM) followed by compounds 2f (IC50 = 0.74 +- 0.001 microM) and 2j (IC50 = 0.89 +- 0.002 microM) when compared with donepezil (IC50 = 0.048 +- 0.001 microM). Donepezil 200-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 23679855-3 2013 To aid in the design of these MTDLs, we report the crystal structures of hAChE (human acetylcholinesterase) in complex with FAS-2 (fasciculin 2) and a hydroxylated derivative of huprine (huprine W), and of hBChE (human butyrylcholinesterase) in complex with tacrine. huprine 187-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-78 23679855-3 2013 To aid in the design of these MTDLs, we report the crystal structures of hAChE (human acetylcholinesterase) in complex with FAS-2 (fasciculin 2) and a hydroxylated derivative of huprine (huprine W), and of hBChE (human butyrylcholinesterase) in complex with tacrine. Tacrine 258-265 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-78 23679855-4 2013 Huprine W in hAChE and tacrine in hBChE reside in strikingly similar positions highlighting the conservation of key interactions, namely, pi-pi/cation-pi interactions with Trp86 (Trp82), and hydrogen bonding with the main chain carbonyl of the catalytic histidine residue. huprine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-18 23679855-5 2013 Huprine W forms additional interactions with hAChE, which explains its superior affinity: the isoquinoline moiety is associated with a group of aromatic residues (Tyr337, Phe338 and Phe295 not present in hBChE) in addition to Trp86; the hydroxyl group is hydrogen bonded to both the catalytic serine residue and residues in the oxyanion hole; and the chlorine substituent is nested in a hydrophobic pocket interacting strongly with Trp439. huprine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-50 23679855-5 2013 Huprine W forms additional interactions with hAChE, which explains its superior affinity: the isoquinoline moiety is associated with a group of aromatic residues (Tyr337, Phe338 and Phe295 not present in hBChE) in addition to Trp86; the hydroxyl group is hydrogen bonded to both the catalytic serine residue and residues in the oxyanion hole; and the chlorine substituent is nested in a hydrophobic pocket interacting strongly with Trp439. isoquinoline 94-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-50 23679855-5 2013 Huprine W forms additional interactions with hAChE, which explains its superior affinity: the isoquinoline moiety is associated with a group of aromatic residues (Tyr337, Phe338 and Phe295 not present in hBChE) in addition to Trp86; the hydroxyl group is hydrogen bonded to both the catalytic serine residue and residues in the oxyanion hole; and the chlorine substituent is nested in a hydrophobic pocket interacting strongly with Trp439. Hydrogen 255-263 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-50 23679855-5 2013 Huprine W forms additional interactions with hAChE, which explains its superior affinity: the isoquinoline moiety is associated with a group of aromatic residues (Tyr337, Phe338 and Phe295 not present in hBChE) in addition to Trp86; the hydroxyl group is hydrogen bonded to both the catalytic serine residue and residues in the oxyanion hole; and the chlorine substituent is nested in a hydrophobic pocket interacting strongly with Trp439. Serine 293-299 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-50 23679855-5 2013 Huprine W forms additional interactions with hAChE, which explains its superior affinity: the isoquinoline moiety is associated with a group of aromatic residues (Tyr337, Phe338 and Phe295 not present in hBChE) in addition to Trp86; the hydroxyl group is hydrogen bonded to both the catalytic serine residue and residues in the oxyanion hole; and the chlorine substituent is nested in a hydrophobic pocket interacting strongly with Trp439. Chlorine 351-359 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-50 23768661-2 2013 In search for multifunctional anti-AD drug candidates, taking into account that the acetylcholinesterase (AChE) and beta-amyloid (Abeta) aggregation are particularly important targets for inhibition, the tacrine and benzothiazole (BTA) moieties were conjugated with suitable linkers in a novel series of hybrids. benzothiazole 216-229 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 23886696-1 2013 Two series of novel acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors containing benzimidazole core structure were synthesized by a four-step reaction pathway starting from 4-fluoro-3-nitrobenzoic acid as the basic compound. benzimidazole 103-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 23768661-2 2013 In search for multifunctional anti-AD drug candidates, taking into account that the acetylcholinesterase (AChE) and beta-amyloid (Abeta) aggregation are particularly important targets for inhibition, the tacrine and benzothiazole (BTA) moieties were conjugated with suitable linkers in a novel series of hybrids. benzothiazole 231-234 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 23768661-4 2013 All the tacrine-BTA hybrids displayed high in vitro activities, namely with IC50 values in the low micromolar to sub-micromolar concentration range towards the inhibition of AChE, and high percentages of inhibition of the self-induced Abeta aggregation. Tacrine 8-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 23768661-4 2013 All the tacrine-BTA hybrids displayed high in vitro activities, namely with IC50 values in the low micromolar to sub-micromolar concentration range towards the inhibition of AChE, and high percentages of inhibition of the self-induced Abeta aggregation. benzothiazole 16-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 23886696-1 2013 Two series of novel acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors containing benzimidazole core structure were synthesized by a four-step reaction pathway starting from 4-fluoro-3-nitrobenzoic acid as the basic compound. benzimidazole 103-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 23886696-1 2013 Two series of novel acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors containing benzimidazole core structure were synthesized by a four-step reaction pathway starting from 4-fluoro-3-nitrobenzoic acid as the basic compound. 4-fluoro-3-nitrobenzoic acid 195-223 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-40 23886696-1 2013 Two series of novel acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors containing benzimidazole core structure were synthesized by a four-step reaction pathway starting from 4-fluoro-3-nitrobenzoic acid as the basic compound. 4-fluoro-3-nitrobenzoic acid 195-223 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 23886696-3 2013 Of the 34 novel synthesized compounds, three benzimidazoles revealed AChE inhibition with IC50<10 muM. Benzimidazoles 45-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 23886696-4 2013 The highest inhibitory activity (IC50=5.12 muM for AChE and IC50=8.63 muM for BChE) corresponds to the compound 5IIc (ethyl 1-(3-(1H-imidazol-1-yl)propyl)-2-(4-nitrophenyl)-1H-benzo[d]imidazole-5-carboxylate). ethyl 1-(3-(1h-imidazol-1-yl)propyl)-2-(4-nitrophenyl)-1h-benzo[d]imidazole-5-carboxylate 118-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 23593992-9 2013 The association of memantine with the acetylcholinesterase inhibitor drugs used to treat dementia symptoms appears to be beneficial, in both experimental and clinical studies. Memantine 19-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 23643737-0 2013 1,4-Substituted 4-(1H)-pyridylene-hydrazone-type inhibitors of AChE, BuChE, and amyloid-beta aggregation crossing the blood-brain barrier. 1,4-substituted 4-(1h)-pyridylene-hydrazone 0-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 23603072-2 2013 For pesticide detection, the enzymes acetylcholinesterase (AChE) and choline oxidase (ChO) were co-immobilized onto the conducting polymer poly(SNS-NH2) films using covalent binding technique. Polymers 131-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 23603072-2 2013 For pesticide detection, the enzymes acetylcholinesterase (AChE) and choline oxidase (ChO) were co-immobilized onto the conducting polymer poly(SNS-NH2) films using covalent binding technique. Polymers 131-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 23603072-2 2013 For pesticide detection, the enzymes acetylcholinesterase (AChE) and choline oxidase (ChO) were co-immobilized onto the conducting polymer poly(SNS-NH2) films using covalent binding technique. -nh2) 147-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 23603072-2 2013 For pesticide detection, the enzymes acetylcholinesterase (AChE) and choline oxidase (ChO) were co-immobilized onto the conducting polymer poly(SNS-NH2) films using covalent binding technique. -nh2) 147-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 22779796-1 2013 Nerve agents such as sarin, VX and tabun are organophosphorus compounds able to inhibit an enzyme acetylcholinesterase (AChE). organophosphorus 45-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-118 22779796-1 2013 Nerve agents such as sarin, VX and tabun are organophosphorus compounds able to inhibit an enzyme acetylcholinesterase (AChE). organophosphorus 45-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 23270368-0 2013 6-acetyl-5H-thiazolo[3,2-a]pyrimidine derivatives as the novel acetylcholinesterase inhibitors: design, synthesis, and biological activity. 6-acetyl-5h-thiazolo[3,2-a]pyrimidine 0-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 23270368-2 2013 A series of 6-acetyl- 5H-thiazolo[3,2-a]pyrimidine derivatives as the novel acetylcholinesterase inhibitors were designed based on virtual screening methods. 6-acetyl- 5h-thiazolo[3,2-a]pyrimidine 12-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 24145276-0 2013 A case report on the use of an acetylcholinesterase inhibitor (donepezil) in traumatic brain injury. Donepezil 63-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 24145276-2 2013 Our patient who suffered TBI was started on a trial of an acetylcholinesterase inhibitor (Donepezil) for five weeks. Donepezil 90-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-78 23791077-0 2013 Selective inhibition of human acetylcholinesterase by xanthine derivatives: in vitro inhibition and molecular modeling investigations. Xanthine 54-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 23791077-1 2013 The commonly used beverage and psychostimulant caffeine is known to inhibit human acetylcholinesterase enzyme. Caffeine 47-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 23791077-5 2013 Among them, propentofylline was the most potent AChE inhibitor (hAChE IC50=6.40 muM). propentofylline 12-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 23791077-9 2013 Molecular modeling investigations indicate that caffeine binds primarily in the catalytic site (Ser203, Glu334 and His447) region of hAChE whereas pentoxifylline and propentofylline are able to bind to both the catalytic site and peripheral anionic site due to their increased bulk/size, thereby exhibiting superior AChE inhibition relative to caffeine. Caffeine 48-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 23791077-9 2013 Molecular modeling investigations indicate that caffeine binds primarily in the catalytic site (Ser203, Glu334 and His447) region of hAChE whereas pentoxifylline and propentofylline are able to bind to both the catalytic site and peripheral anionic site due to their increased bulk/size, thereby exhibiting superior AChE inhibition relative to caffeine. Caffeine 344-352 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 23791077-11 2013 In summary, our study has important implications in the development of novel caffeine derivatives as selective AChE inhibitors with potential application as cognitive enhancers and to treat various forms of dementia. Caffeine 77-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 24964452-1 2013 Neostigmine is an acetylcholinesterase inhibitor that is increasingly used as a medical treatment in cases of pseudo-obstruction. Neostigmine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 23643737-2 2013 Here, following the cholinergic hypothesis, we aimed to inhibit both acetyl- and butyrylcholinesterase (AChE and BuChE) in order to increase the concentration of acetylcholine in the synaptic cleft. Acetylcholine 162-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 23643737-4 2013 Based on a recently identified AChE inhibitor with a 1,4-substituted 4-(1H)-pyridylene-hydrazone skeleton, a substance library has been generated and tested for inhibition of AChE, BuChE, and fibril formation. 1,4-substituted 4-(1h)-pyridylene-hydrazone 53-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 23880932-2 2013 APS8, an analog of poly-APS with defined alkyl chain length and molecular size, non-competitively inhibits alpha7 nicotinic acetylcholine receptors (nAChRs) at nanomolar concentrations that are too low to be acetylcholinesterase (AChE) inhibitory or generally cytotoxic. aps8 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-228 23880932-2 2013 APS8, an analog of poly-APS with defined alkyl chain length and molecular size, non-competitively inhibits alpha7 nicotinic acetylcholine receptors (nAChRs) at nanomolar concentrations that are too low to be acetylcholinesterase (AChE) inhibitory or generally cytotoxic. aps8 0-4 acetylcholinesterase (Cartwright blood group) Homo sapiens 230-234 23500378-8 2013 AChE/Ag/N F TNs hybrid system was used to study AChE inhibition induced by (R)-Sal and (R)-NMSal. (r)-sal 75-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 23454740-4 2013 The R-GO FET immobilized with acetylcholinesterase (AchE) was used to detect Ach in the concentration range of 0.1-10mM by sensing protons generated during the enzymatic reactions. Acetylcholine 52-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 23796225-0 2013 Molecular docking and QSAR studies: noncovalent interaction between acephate analogous and the receptor site of human acetylcholinesterase. acephate 68-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 23796225-3 2013 Docking analysis showed that hydrophobic interaction and hydrogen bonding were created between the functional groups of Ace derivatives and the receptor sites of acetylcholinesterase. Hydrogen 57-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 162-182 23500378-8 2013 AChE/Ag/N F TNs hybrid system was used to study AChE inhibition induced by (R)-Sal and (R)-NMSal. (r)-sal 75-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 23500378-8 2013 AChE/Ag/N F TNs hybrid system was used to study AChE inhibition induced by (R)-Sal and (R)-NMSal. (r)-nmsal 87-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 23500378-8 2013 AChE/Ag/N F TNs hybrid system was used to study AChE inhibition induced by (R)-Sal and (R)-NMSal. (r)-nmsal 87-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 23500378-9 2013 The result proved that both (R)-Sal and (R)-NMSal exhibited mixed and reversible inhibition against AChE. (r)-sal 28-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 23500378-9 2013 The result proved that both (R)-Sal and (R)-NMSal exhibited mixed and reversible inhibition against AChE. (r)-nmsal 40-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 23840379-3 2013 The action of ACh on these distant cells is unlikely to occur through diffusion, given that ACh is very short-lived in the presence of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), two extremely efficient ACh-degrading enzymes abundantly present in extracellular fluids. Acetylcholine 14-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 23643881-1 2013 We have recently synthesized a series of phosphorylated flavonoids and identified some of them as potent inhibitors of pancreatic cholesterol esterase (CEase) with excellent selectivity for CEase over acetylcholinesterase (AChE). Flavonoids 56-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 223-227 24381529-1 2013 Acetylcholinesterase (AChE) (EC 3.1.1.7) is an important enzyme that breaks down of acetylcholine in synaptic cleft in neuronal junctions. Acetylcholine 84-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24381529-1 2013 Acetylcholinesterase (AChE) (EC 3.1.1.7) is an important enzyme that breaks down of acetylcholine in synaptic cleft in neuronal junctions. Acetylcholine 84-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 24381530-2 2013 The fact that naturally-occurring compounds from plants are considered to be a potential source of new inhibitors has led to the discovery of an important number of secondary metabolites and plant extracts with the ability of inhibiting the enzyme AChE, which, according to the cholinergic hypothesis, increases the levels of the neurotransmitter acetylcholine in the brain, thus improving cholinergic functions in patients with Alzheimer"s disease and alleviating the symptoms of this neurological disorder. Acetylcholine 347-360 acetylcholinesterase (Cartwright blood group) Homo sapiens 248-252 24381530-3 2013 This review summarizes a total of 128 studies which correspond to the most relevant research work published during 2006-2012 (1st semester) on plant-derived compounds, plant extracts and essential oils found to elicit AChE inhibition. Oils, Volatile 187-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 218-222 23721952-0 2013 An atom economic synthesis and AChE inhibitory activity of novel dispiro 7-aryltetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole and 4-aryloctahydroindolizine N-methylpiperidin-4-one hybrid heterocycles. 7-aryltetrahydro-1h-pyrrolo[1,2-c][1,3]thiazole 73-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 23721952-0 2013 An atom economic synthesis and AChE inhibitory activity of novel dispiro 7-aryltetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole and 4-aryloctahydroindolizine N-methylpiperidin-4-one hybrid heterocycles. 4-aryloctahydroindolizine n-methylpiperidin-4-one 125-174 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 23408593-0 2013 Interaction of metal chelators with different molecular forms of acetylcholinesterase and its significance in Alzheimer"s disease treatment. Metals 15-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 23408593-4 2013 Hence, a comparative study on the effect of metal chelators on both the esterase and AAA activity of AChE globular (G4 and G1) molecular forms was performed. Metals 44-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 23408593-7 2013 Kinetic studies on both forms of AChE show that 1,10-phenanthroline inhibits esterase in competitive and AAA activity in non-competitive manner. 1,10-phenanthroline 48-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 23408593-8 2013 Protection studies further revealed that the nature of 1,10-phenanthroline inhibition on AChE is through its direct binding to protein rather than its metal chelation property. 1,10-phenanthroline 55-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 23408593-8 2013 Protection studies further revealed that the nature of 1,10-phenanthroline inhibition on AChE is through its direct binding to protein rather than its metal chelation property. Metals 151-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 23408593-11 2013 Such an interaction of 1,10-phenanthroline on PAS may hinder "AChE-Abeta peptide" complex formation. 1,10-phenanthroline 23-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 23472585-4 2013 sym-Triazine inhibition of acetylcholinesterase (AChE) activity was observed in cytosol extracted from differentiated human SH-SY5Y neuronal cells and also using human erythrocyte AChE. 1,3,5-TRIAZINE 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 23472585-4 2013 sym-Triazine inhibition of acetylcholinesterase (AChE) activity was observed in cytosol extracted from differentiated human SH-SY5Y neuronal cells and also using human erythrocyte AChE. 1,3,5-TRIAZINE 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 23472585-4 2013 sym-Triazine inhibition of acetylcholinesterase (AChE) activity was observed in cytosol extracted from differentiated human SH-SY5Y neuronal cells and also using human erythrocyte AChE. 1,3,5-TRIAZINE 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 23719283-0 2013 Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase. 2-aminobenzimidazole 71-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-136 23719283-3 2013 A number of the 2-aminobenzimidazole derivatives showed good inhibitory activities to AChE and BuChE. 2-aminobenzimidazole 16-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 23930001-4 2013 RESULTS: Inhibition of acetylcholinesterase showed that 1-butanol fraction of the two medicines were noncompetitive inhibition, apparent inhibition constants were 9.947 and 7.1523. Butanols 58-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 24187393-7 2013 One experimental compound, 2-((2-ethylbutyl)thio)phenyl methylcarbamate, possesses >300-fold selectivity for BmAChE1 and PpAChE over human AChE, and a mouse oral LD50 of >1500 mg/kg, thus providing an excellent new lead for vector control. SCHEMBL80510 27-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 24347920-2 2013 Decreased concentration of the neurotransmitter, acetylcholine (ACh), appears to be critical element in the development of dementia, and the most appropriate therapeutic approach to treat AD and other form of dementia is to restore acetylcholine levels by inhibiting both major form of cholinesterase: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Acetylcholine 49-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 302-322 24347920-2 2013 Decreased concentration of the neurotransmitter, acetylcholine (ACh), appears to be critical element in the development of dementia, and the most appropriate therapeutic approach to treat AD and other form of dementia is to restore acetylcholine levels by inhibiting both major form of cholinesterase: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Acetylcholine 49-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 324-328 24347920-2 2013 Decreased concentration of the neurotransmitter, acetylcholine (ACh), appears to be critical element in the development of dementia, and the most appropriate therapeutic approach to treat AD and other form of dementia is to restore acetylcholine levels by inhibiting both major form of cholinesterase: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Acetylcholine 64-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 302-322 24347920-2 2013 Decreased concentration of the neurotransmitter, acetylcholine (ACh), appears to be critical element in the development of dementia, and the most appropriate therapeutic approach to treat AD and other form of dementia is to restore acetylcholine levels by inhibiting both major form of cholinesterase: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Acetylcholine 64-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 324-328 24347920-2 2013 Decreased concentration of the neurotransmitter, acetylcholine (ACh), appears to be critical element in the development of dementia, and the most appropriate therapeutic approach to treat AD and other form of dementia is to restore acetylcholine levels by inhibiting both major form of cholinesterase: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Acetylcholine 232-245 acetylcholinesterase (Cartwright blood group) Homo sapiens 302-322 24347920-2 2013 Decreased concentration of the neurotransmitter, acetylcholine (ACh), appears to be critical element in the development of dementia, and the most appropriate therapeutic approach to treat AD and other form of dementia is to restore acetylcholine levels by inhibiting both major form of cholinesterase: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Acetylcholine 232-245 acetylcholinesterase (Cartwright blood group) Homo sapiens 324-328 24164032-7 2013 Seven isoquinoline alkaloids, namely jatrorrhizine, epiberberine, columbamine, coptisine, corysamine, palmatine and berberine were identified to be active as the inhibitors of ACHE. isoquinoline alkaloids 6-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 24164032-7 2013 Seven isoquinoline alkaloids, namely jatrorrhizine, epiberberine, columbamine, coptisine, corysamine, palmatine and berberine were identified to be active as the inhibitors of ACHE. jatrorrhizine 37-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 24164032-7 2013 Seven isoquinoline alkaloids, namely jatrorrhizine, epiberberine, columbamine, coptisine, corysamine, palmatine and berberine were identified to be active as the inhibitors of ACHE. epiberberine 52-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 24164032-7 2013 Seven isoquinoline alkaloids, namely jatrorrhizine, epiberberine, columbamine, coptisine, corysamine, palmatine and berberine were identified to be active as the inhibitors of ACHE. columbamine 66-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 24164032-7 2013 Seven isoquinoline alkaloids, namely jatrorrhizine, epiberberine, columbamine, coptisine, corysamine, palmatine and berberine were identified to be active as the inhibitors of ACHE. coptisine 79-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 24164032-7 2013 Seven isoquinoline alkaloids, namely jatrorrhizine, epiberberine, columbamine, coptisine, corysamine, palmatine and berberine were identified to be active as the inhibitors of ACHE. Corysamine 90-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 24164032-7 2013 Seven isoquinoline alkaloids, namely jatrorrhizine, epiberberine, columbamine, coptisine, corysamine, palmatine and berberine were identified to be active as the inhibitors of ACHE. palmatine 102-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 24164032-7 2013 Seven isoquinoline alkaloids, namely jatrorrhizine, epiberberine, columbamine, coptisine, corysamine, palmatine and berberine were identified to be active as the inhibitors of ACHE. Berberine 55-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 23936743-1 2013 Acetylcholinesterase and Butyrylcholinesterase share unravelling link with components of metabolic syndromes that"s characterised by low levels of HDL cholesterol, obesity, high fast aldohexose levels, hyper-trigliceridaemia and high blood pressure, by regulation of cholinergic transmission and therefore the enzyme activity within a living system. Cholesterol 151-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 23936743-2 2013 The phosphomotifs associated with amino acid and tyrosine binding motifs in AChE and BChE were known to be common. Tyrosine 49-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 23936743-6 2013 Medicinal compounds like Ortho-7, Dibucaine and HI-6 are predicted as good targets for modeled AChE and BChE proteins based on docking studies. Dibucaine 34-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 23936743-6 2013 Medicinal compounds like Ortho-7, Dibucaine and HI-6 are predicted as good targets for modeled AChE and BChE proteins based on docking studies. asoxime chloride 48-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 23840379-3 2013 The action of ACh on these distant cells is unlikely to occur through diffusion, given that ACh is very short-lived in the presence of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), two extremely efficient ACh-degrading enzymes abundantly present in extracellular fluids. Acetylcholine 92-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 23840379-3 2013 The action of ACh on these distant cells is unlikely to occur through diffusion, given that ACh is very short-lived in the presence of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), two extremely efficient ACh-degrading enzymes abundantly present in extracellular fluids. Acetylcholine 92-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 23499967-1 2013 A sensitive amperometric acetylcholinesterase (AChE) biosensor based on platinum nanoparticles (Pt NPs), carboxylic graphene (CGR), and nafion (NF)-modified glassy carbon electrode (GCE) has been developed. Platinum 72-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 23499967-1 2013 A sensitive amperometric acetylcholinesterase (AChE) biosensor based on platinum nanoparticles (Pt NPs), carboxylic graphene (CGR), and nafion (NF)-modified glassy carbon electrode (GCE) has been developed. perfluorosulfonic acid 136-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 23499967-1 2013 A sensitive amperometric acetylcholinesterase (AChE) biosensor based on platinum nanoparticles (Pt NPs), carboxylic graphene (CGR), and nafion (NF)-modified glassy carbon electrode (GCE) has been developed. Carbon 164-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 23535563-2 2013 One strategy currently being explored for the development of new therapeutics for AD involves linking tacrine, a known acetylcholinesterase (AChE) inhibitor, to another drug to create bifunctional hybrids. Tacrine 102-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 23535563-2 2013 One strategy currently being explored for the development of new therapeutics for AD involves linking tacrine, a known acetylcholinesterase (AChE) inhibitor, to another drug to create bifunctional hybrids. Tacrine 102-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 23535563-4 2013 In this study, three series of 6-chlorotacrine with linkers varying in terminal functional group and length were synthesized, evaluated for AChE inhibition, and compared to tacrine and 6-chlorotacrine-mefenamic acid hybrids. 6-chlorotacrine 31-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 23618168-1 2013 Application to acetylcholinesterase inhibitor galantamine and its determination in pharmaceuticals and human urine. Galantamine 46-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-35 23618168-5 2013 The method developed is applied to the acetylcholinesterase inhibitor galantamine, using an acetylcholine-selective electrode. Galantamine 70-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 23631528-1 2013 Amphiphilic peptides were designed to fold into a beta-sheet monolayer structure while presenting the catalytic triad residues of the enzyme, acetylcholinesterase (Glu, His, and Ser), to a solution containing the organophosphate, paraoxon. Glutamic Acid 164-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 23631528-1 2013 Amphiphilic peptides were designed to fold into a beta-sheet monolayer structure while presenting the catalytic triad residues of the enzyme, acetylcholinesterase (Glu, His, and Ser), to a solution containing the organophosphate, paraoxon. Histidine 169-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 23631528-1 2013 Amphiphilic peptides were designed to fold into a beta-sheet monolayer structure while presenting the catalytic triad residues of the enzyme, acetylcholinesterase (Glu, His, and Ser), to a solution containing the organophosphate, paraoxon. Serine 178-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 23631528-1 2013 Amphiphilic peptides were designed to fold into a beta-sheet monolayer structure while presenting the catalytic triad residues of the enzyme, acetylcholinesterase (Glu, His, and Ser), to a solution containing the organophosphate, paraoxon. Organophosphates 213-228 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 23631528-1 2013 Amphiphilic peptides were designed to fold into a beta-sheet monolayer structure while presenting the catalytic triad residues of the enzyme, acetylcholinesterase (Glu, His, and Ser), to a solution containing the organophosphate, paraoxon. Paraoxon 230-238 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 23631528-6 2013 Circular dichroism revealed that the peptide most sensitive to interactions with paraoxon was that with the triad residues in the order Glu, Ser, and His, which appears to be appropriate for supporting a catalytic mechanism similar to that in the acetylcholinesterase enzyme. Paraoxon 81-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 247-267 23631528-6 2013 Circular dichroism revealed that the peptide most sensitive to interactions with paraoxon was that with the triad residues in the order Glu, Ser, and His, which appears to be appropriate for supporting a catalytic mechanism similar to that in the acetylcholinesterase enzyme. Glutamic Acid 136-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 247-267 23631528-6 2013 Circular dichroism revealed that the peptide most sensitive to interactions with paraoxon was that with the triad residues in the order Glu, Ser, and His, which appears to be appropriate for supporting a catalytic mechanism similar to that in the acetylcholinesterase enzyme. Serine 141-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 247-267 23631528-6 2013 Circular dichroism revealed that the peptide most sensitive to interactions with paraoxon was that with the triad residues in the order Glu, Ser, and His, which appears to be appropriate for supporting a catalytic mechanism similar to that in the acetylcholinesterase enzyme. Histidine 150-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 247-267 23758724-0 2013 Synthesis, docking and acetylcholinesterase inhibitory assessment of 2-(2-(4-Benzylpiperazin-1-yl)ethyl)isoindoline-1,3-dione derivatives with potential anti-Alzheimer effects. CHEMBL3793386 69-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 23758724-3 2013 In recent years, acetylcholinesterase (AChE) inhibitors like donepezil with prevention of acetylcholine hydrolysis can enhance the duration of action of acetylcholine in synaptic cleft and improve the dementia associated with Alzheimer"s disease. Donepezil 61-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 23758724-3 2013 In recent years, acetylcholinesterase (AChE) inhibitors like donepezil with prevention of acetylcholine hydrolysis can enhance the duration of action of acetylcholine in synaptic cleft and improve the dementia associated with Alzheimer"s disease. Donepezil 61-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 23758724-3 2013 In recent years, acetylcholinesterase (AChE) inhibitors like donepezil with prevention of acetylcholine hydrolysis can enhance the duration of action of acetylcholine in synaptic cleft and improve the dementia associated with Alzheimer"s disease. Acetylcholine 17-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 23758724-3 2013 In recent years, acetylcholinesterase (AChE) inhibitors like donepezil with prevention of acetylcholine hydrolysis can enhance the duration of action of acetylcholine in synaptic cleft and improve the dementia associated with Alzheimer"s disease. Acetylcholine 90-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 23758724-3 2013 In recent years, acetylcholinesterase (AChE) inhibitors like donepezil with prevention of acetylcholine hydrolysis can enhance the duration of action of acetylcholine in synaptic cleft and improve the dementia associated with Alzheimer"s disease. Acetylcholine 90-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 23758724-4 2013 RESULTS: Design, synthesis and assessment of anticholinesterase activity of 2-(2-(4-Benzylpiperazin-1-yl)ethyl)isoindoline-1,3-dione derivatives showed prepared compounds can function as potential acetylcholinesterase inhibitor. CHEMBL3793386 76-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-217 23447373-3 2013 We hypothesized that older adults with mild memory deficits would show behavioral and functional network enhancements with an acetylcholinesterase inhibitor treatment (donepezil) when compared to a placebo control group. Donepezil 168-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 23819936-3 2013 After a deliberate ingestion of malathion, a 55-year-old male suffering from miosis, somnolence, bradycardia, muscular fasciculations, rales on auscultation, respiratory insufficiency, as well as from an inhibition of red blood cell acetylcholinesterase (AChE) and plasma butyrylcholinesterase (BuChE), was admitted to hospital. Malathion 32-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-253 23819936-3 2013 After a deliberate ingestion of malathion, a 55-year-old male suffering from miosis, somnolence, bradycardia, muscular fasciculations, rales on auscultation, respiratory insufficiency, as well as from an inhibition of red blood cell acetylcholinesterase (AChE) and plasma butyrylcholinesterase (BuChE), was admitted to hospital. Malathion 32-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 255-259 23602518-1 2013 A series of hitherto unreported pyrido-pyrimidine-2-ones/pyrimidine-2-thiones were synthesized under microwave assisted solvent free reaction conditions in excellent yields and evaluated in vitro for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes inhibitory activity. pyrido-pyrimidine-2-ones 32-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 206-226 23602518-1 2013 A series of hitherto unreported pyrido-pyrimidine-2-ones/pyrimidine-2-thiones were synthesized under microwave assisted solvent free reaction conditions in excellent yields and evaluated in vitro for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes inhibitory activity. pyrido-pyrimidine-2-ones 32-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 228-232 23602518-1 2013 A series of hitherto unreported pyrido-pyrimidine-2-ones/pyrimidine-2-thiones were synthesized under microwave assisted solvent free reaction conditions in excellent yields and evaluated in vitro for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes inhibitory activity. pyrimidine-2-thiones 57-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 206-226 23602518-1 2013 A series of hitherto unreported pyrido-pyrimidine-2-ones/pyrimidine-2-thiones were synthesized under microwave assisted solvent free reaction conditions in excellent yields and evaluated in vitro for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes inhibitory activity. pyrimidine-2-thiones 57-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 228-232 23602518-2 2013 Among the pyridopyrimidine derivatives, 7e and 7l displayed 2.5- and 1.5-fold higher enzyme inhibitory activities against AChE as compared to standard drug, galanthamine, with IC50 of 0.80 and 1.37 muM, respectively. pyrido(3,2-d)pyrimidine 10-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 23602518-2 2013 Among the pyridopyrimidine derivatives, 7e and 7l displayed 2.5- and 1.5-fold higher enzyme inhibitory activities against AChE as compared to standard drug, galanthamine, with IC50 of 0.80 and 1.37 muM, respectively. Galantamine 157-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 23474324-0 2013 Can acetylcholinesterase activity be considered as a reliable biomarker for the assessment of cadmium-induced neurotoxicity? Cadmium 94-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 23474324-2 2013 (2012) recently reported the findings of a long-awaited study on the effects of long-term dietary-induced exposure to cadmium (Cd) on the acetylcholinesterase (AChE) activity of adult rodents" brain regions. Cadmium 118-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 23474324-2 2013 (2012) recently reported the findings of a long-awaited study on the effects of long-term dietary-induced exposure to cadmium (Cd) on the acetylcholinesterase (AChE) activity of adult rodents" brain regions. Cadmium 118-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 23474324-2 2013 (2012) recently reported the findings of a long-awaited study on the effects of long-term dietary-induced exposure to cadmium (Cd) on the acetylcholinesterase (AChE) activity of adult rodents" brain regions. Cadmium 127-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 23474324-2 2013 (2012) recently reported the findings of a long-awaited study on the effects of long-term dietary-induced exposure to cadmium (Cd) on the acetylcholinesterase (AChE) activity of adult rodents" brain regions. Cadmium 127-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 23474324-3 2013 Their study can be regarded as a significant contribution to the field, as there is paucity of information on the AChE activity in brain regions following exposure to Cd. Cadmium 167-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 23474324-4 2013 However, the Cd-induced modulation of AChE activity is an issue surrounded by controversy. Cadmium 13-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 23474324-5 2013 We, herein, discuss and summarize the relative in vivo and in vitro experimental data, and set out to answer the straightforward question: can AChE activity be considered as a reliable biomarker for the assessment of Cd-induced neurotoxicity? Cadmium 217-219 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 23474324-7 2013 We make a plea that authors aiming to explore this potential use of brain AChE activity in the future: (a) are aware of the biases that their experimental approach might exert upon this neurochemical parameter, (b) avoid the use of anaesthesia as a mode of sacrifice and clarify its timing, (c) decide upon the use of previously-studied in vivo experimental schemes (so that they can provide comparable results), and finally, (d) identify pharmacological, biochemical and molecular approaches that are appropriate to clarify the implicated mechanism(s) through which Cd modifies AChE activity. Cadmium 567-569 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 23474396-0 2013 The effect of bromfenvinphos, its impurities and chlorfenvinphos on acetylcholinesterase activity. bromfenvinphos 14-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 23474396-0 2013 The effect of bromfenvinphos, its impurities and chlorfenvinphos on acetylcholinesterase activity. Chlorfenvinphos 49-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 23474396-1 2013 The aim of this work was to examine the effect of two organophosphorous compounds i.e. bromfenvinphos (BFVF) and chlorfenvinphos (CFVF) possessing acaricidal and insecticidal properties, on the activity of human erythrocytes acetylcholinesterase (AChE, EC 3.1.1.7). organophosphorous 54-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 225-245 23474396-1 2013 The aim of this work was to examine the effect of two organophosphorous compounds i.e. bromfenvinphos (BFVF) and chlorfenvinphos (CFVF) possessing acaricidal and insecticidal properties, on the activity of human erythrocytes acetylcholinesterase (AChE, EC 3.1.1.7). organophosphorous 54-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 247-251 23474396-1 2013 The aim of this work was to examine the effect of two organophosphorous compounds i.e. bromfenvinphos (BFVF) and chlorfenvinphos (CFVF) possessing acaricidal and insecticidal properties, on the activity of human erythrocytes acetylcholinesterase (AChE, EC 3.1.1.7). bromfenvinphos 87-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 225-245 23474396-1 2013 The aim of this work was to examine the effect of two organophosphorous compounds i.e. bromfenvinphos (BFVF) and chlorfenvinphos (CFVF) possessing acaricidal and insecticidal properties, on the activity of human erythrocytes acetylcholinesterase (AChE, EC 3.1.1.7). bromfenvinphos 87-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 247-251 23474396-2 2013 Moreover, the effect of five bromfenvinphos production impurities on AChE activity was studied. bromfenvinphos 29-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 23474396-6 2013 Basic significance in AChE activity inhibition has the type of halogen in vinyl group. Halogens 63-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 23474396-11 2013 Two impurities of bromfenvinphos such as: dihydro-bromfenvinphos and dibromo-bromfenvinphos revealed significant effect on the AChE activity, which may be connected with the presence a phosphate group in these substances. bromfenvinphos 18-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 23474396-11 2013 Two impurities of bromfenvinphos such as: dihydro-bromfenvinphos and dibromo-bromfenvinphos revealed significant effect on the AChE activity, which may be connected with the presence a phosphate group in these substances. dihydro-bromfenvinphos 42-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 23474396-11 2013 Two impurities of bromfenvinphos such as: dihydro-bromfenvinphos and dibromo-bromfenvinphos revealed significant effect on the AChE activity, which may be connected with the presence a phosphate group in these substances. dibromo-bromfenvinphos 69-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 23474396-11 2013 Two impurities of bromfenvinphos such as: dihydro-bromfenvinphos and dibromo-bromfenvinphos revealed significant effect on the AChE activity, which may be connected with the presence a phosphate group in these substances. Phosphates 185-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 22299580-0 2013 Synthesis and biological evaluation of some thiazole derivatives as new cholinesterase inhibitors. Thiazoles 44-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-86 23676090-5 2013 Kinetic inhibition analysis clearly demonstrated that beta-naphthotacrine10 behaves as a mixed-type inhibitor (Ki2= 0.72 +- 0.06 muM) at high substrate concentrations (0.5-10 muM), while at low concentrations (0.01-0.1 muM) it behaves as a hAChE competitive inhibitor (Ki1= 0.007 +- 0.001 muM). beta-naphthotacrine10 54-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 240-245 23676090-6 2013 These findings identified beta-naphthotacrine10 as a potent and selective hAChE inhibitor in a nanomolar range, with toxicity lower than that of tacrine both in human hepatocytes and rat cortical neurons, with a potent neuroprotective activity and, consequently, an attractive multipotent active molecule of potential application in AD treatment. beta-naphthotacrine10 26-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-79 23676090-6 2013 These findings identified beta-naphthotacrine10 as a potent and selective hAChE inhibitor in a nanomolar range, with toxicity lower than that of tacrine both in human hepatocytes and rat cortical neurons, with a potent neuroprotective activity and, consequently, an attractive multipotent active molecule of potential application in AD treatment. Tacrine 38-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-79 23263540-0 2013 A therapeutic approach to cerebrovascular diseases based on indole substituted hydrazides and hydrazines able to interact with human vascular adhesion protein-1, monoamine oxidases (A and B), AChE and BuChE. indole 60-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 22397393-0 2013 Synthesis of alpha-oxycarbanilinophosphonates and their anticholinesterase activities: the most potent derivative is bound to the peripheral site of acetylcholinesterase. alpha-oxycarbanilinophosphonates 13-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-169 22397393-4 2013 This puts forward the potential of compound 4h and its derivatives to be used in the design of dual inhibitors: inhibition of the catalytic activity of AChE and of amyloid beta aggregation. 4h 44-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 23263540-0 2013 A therapeutic approach to cerebrovascular diseases based on indole substituted hydrazides and hydrazines able to interact with human vascular adhesion protein-1, monoamine oxidases (A and B), AChE and BuChE. Isoniazid 79-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 23263540-0 2013 A therapeutic approach to cerebrovascular diseases based on indole substituted hydrazides and hydrazines able to interact with human vascular adhesion protein-1, monoamine oxidases (A and B), AChE and BuChE. Hydrazines 94-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 23263540-1 2013 Herein, we report the biological evaluation of a series of indole substituted hydrazides and hydrazines throughout the assessment of their multipotent inhibitory potency towards monoamine oxidase (MAO) A and B, semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1), and the cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). indole 59-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 316-336 23263540-1 2013 Herein, we report the biological evaluation of a series of indole substituted hydrazides and hydrazines throughout the assessment of their multipotent inhibitory potency towards monoamine oxidase (MAO) A and B, semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1), and the cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). indole 59-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 338-342 23562497-2 2013 We have focussed on the observation that AChE, operating as a trophic agent independent of its enzymatic action, does indeed trigger calcium entry into neurons. Calcium 133-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 23676090-1 2013 The synthesis, toxicity, neuroprotection, and human acetylcholinesterase (hAChE)/ human butyrylcholinesterase (hBuChE) inhibition properties of beta-naphthotacrines1-14 as new drugs for Alzheimer"s disease (AD) potential treatment, are reported. beta-naphthotacrines1-14 144-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-79 23676090-4 2013 An efficient and selective inhibition of hAChE, was only observed for the beta-naphthotacrines bearing electron-donating substituents at the aromatic ring, beta-naphthotacrine10 being the most potent (hAChE: IC50 = 0.083 +- 0.024 muM). beta-naphthotacrines 74-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-46 23676090-4 2013 An efficient and selective inhibition of hAChE, was only observed for the beta-naphthotacrines bearing electron-donating substituents at the aromatic ring, beta-naphthotacrine10 being the most potent (hAChE: IC50 = 0.083 +- 0.024 muM). beta-naphthotacrines 74-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 201-206 23676090-4 2013 An efficient and selective inhibition of hAChE, was only observed for the beta-naphthotacrines bearing electron-donating substituents at the aromatic ring, beta-naphthotacrine10 being the most potent (hAChE: IC50 = 0.083 +- 0.024 muM). beta-naphthotacrine10 156-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-46 23676090-4 2013 An efficient and selective inhibition of hAChE, was only observed for the beta-naphthotacrines bearing electron-donating substituents at the aromatic ring, beta-naphthotacrine10 being the most potent (hAChE: IC50 = 0.083 +- 0.024 muM). beta-naphthotacrine10 156-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 201-206 23570516-0 2013 Molecular interactions of 4-acetoxy-plakinamine B with peripheral anionic and other catalytic subsites of the aromatic gorge of acetylcholinesterase: computational and structural insights. 4-acetoxyplakinamine B 26-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-148 23570516-1 2013 CONTEXT: A steroidal alkaloid, 4-acetoxy-plakinamine B (4APB), is a recently discovered marine natural product with inhibitory effect against acetylcholinesterase (AChE), but its mechanism of interaction with the enzyme remains to be elucidated. Alkaloids 21-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 23570516-1 2013 CONTEXT: A steroidal alkaloid, 4-acetoxy-plakinamine B (4APB), is a recently discovered marine natural product with inhibitory effect against acetylcholinesterase (AChE), but its mechanism of interaction with the enzyme remains to be elucidated. Alkaloids 21-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 23570516-1 2013 CONTEXT: A steroidal alkaloid, 4-acetoxy-plakinamine B (4APB), is a recently discovered marine natural product with inhibitory effect against acetylcholinesterase (AChE), but its mechanism of interaction with the enzyme remains to be elucidated. 4-acetoxyplakinamine B 31-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 23570516-1 2013 CONTEXT: A steroidal alkaloid, 4-acetoxy-plakinamine B (4APB), is a recently discovered marine natural product with inhibitory effect against acetylcholinesterase (AChE), but its mechanism of interaction with the enzyme remains to be elucidated. 4-acetoxyplakinamine B 31-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 23570516-1 2013 CONTEXT: A steroidal alkaloid, 4-acetoxy-plakinamine B (4APB), is a recently discovered marine natural product with inhibitory effect against acetylcholinesterase (AChE), but its mechanism of interaction with the enzyme remains to be elucidated. 4-acetoxyplakinamine B 56-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 23570516-1 2013 CONTEXT: A steroidal alkaloid, 4-acetoxy-plakinamine B (4APB), is a recently discovered marine natural product with inhibitory effect against acetylcholinesterase (AChE), but its mechanism of interaction with the enzyme remains to be elucidated. 4-acetoxyplakinamine B 56-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 23570516-12 2013 This study outlines a strategy for designing novel derivatives of 4APB with potentially better AChE inhibitory activities through interaction at the PAS and AS sites. Protactinium 149-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 23570516-12 2013 This study outlines a strategy for designing novel derivatives of 4APB with potentially better AChE inhibitory activities through interaction at the PAS and AS sites. Arsenic 150-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 23597308-2 2013 In this method, the AChE molecules catalyzed the hydrolysis of acetylthiocholine (ATCl) to form thiocholine, which in turn can specifically react with fluorescent squaraine derivative, a specific chemodosimeter for thiol-containing compounds, resulting in fluorescence quenching and offering a low fluorometric background for the further detection of AChE inhibitor. Acetylthiocholine 63-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 23597308-2 2013 In this method, the AChE molecules catalyzed the hydrolysis of acetylthiocholine (ATCl) to form thiocholine, which in turn can specifically react with fluorescent squaraine derivative, a specific chemodosimeter for thiol-containing compounds, resulting in fluorescence quenching and offering a low fluorometric background for the further detection of AChE inhibitor. Acetylthiocholine 63-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 351-355 23597308-2 2013 In this method, the AChE molecules catalyzed the hydrolysis of acetylthiocholine (ATCl) to form thiocholine, which in turn can specifically react with fluorescent squaraine derivative, a specific chemodosimeter for thiol-containing compounds, resulting in fluorescence quenching and offering a low fluorometric background for the further detection of AChE inhibitor. Acetylthiocholine 82-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 23597308-2 2013 In this method, the AChE molecules catalyzed the hydrolysis of acetylthiocholine (ATCl) to form thiocholine, which in turn can specifically react with fluorescent squaraine derivative, a specific chemodosimeter for thiol-containing compounds, resulting in fluorescence quenching and offering a low fluorometric background for the further detection of AChE inhibitor. Acetylthiocholine 82-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 351-355 23597308-2 2013 In this method, the AChE molecules catalyzed the hydrolysis of acetylthiocholine (ATCl) to form thiocholine, which in turn can specifically react with fluorescent squaraine derivative, a specific chemodosimeter for thiol-containing compounds, resulting in fluorescence quenching and offering a low fluorometric background for the further detection of AChE inhibitor. Thiocholine 69-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 23597308-2 2013 In this method, the AChE molecules catalyzed the hydrolysis of acetylthiocholine (ATCl) to form thiocholine, which in turn can specifically react with fluorescent squaraine derivative, a specific chemodosimeter for thiol-containing compounds, resulting in fluorescence quenching and offering a low fluorometric background for the further detection of AChE inhibitor. Thiocholine 69-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 351-355 23597308-2 2013 In this method, the AChE molecules catalyzed the hydrolysis of acetylthiocholine (ATCl) to form thiocholine, which in turn can specifically react with fluorescent squaraine derivative, a specific chemodosimeter for thiol-containing compounds, resulting in fluorescence quenching and offering a low fluorometric background for the further detection of AChE inhibitor. Sulfhydryl Compounds 215-220 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 23597308-2 2013 In this method, the AChE molecules catalyzed the hydrolysis of acetylthiocholine (ATCl) to form thiocholine, which in turn can specifically react with fluorescent squaraine derivative, a specific chemodosimeter for thiol-containing compounds, resulting in fluorescence quenching and offering a low fluorometric background for the further detection of AChE inhibitor. Sulfhydryl Compounds 215-220 acetylcholinesterase (Cartwright blood group) Homo sapiens 351-355 23618147-0 2013 Development of an acetylcholinesterase immobilized flow through amperometric detector based on thiocholine detection at a silver electrode. Thiocholine 95-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 23698772-0 2013 Caffeine inhibits acetylcholinesterase, but not butyrylcholinesterase. Caffeine 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 23698772-5 2013 In the present work, we focused on the question whether caffeine can inhibit acetylcholinesterase (AChE) and/or, butyrylcholinesterase (BChE), the two enzymes participating in cholinergic neurotransmission. Caffeine 56-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 23698772-5 2013 In the present work, we focused on the question whether caffeine can inhibit acetylcholinesterase (AChE) and/or, butyrylcholinesterase (BChE), the two enzymes participating in cholinergic neurotransmission. Caffeine 56-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 23698772-6 2013 A standard Ellman test with human AChE and BChE was done for altering concentrations of caffeine. Caffeine 88-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 23698772-9 2013 In compliance with Dixon"s plot, caffeine was proved to be a non-competitive inhibitor of AChE and BChE. Caffeine 33-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 23782591-1 2013 BACKGROUND: The class of acetylcholinesterase inhibitors (ChEI), including donepezil, rivastigmine, and galantamine, have similar efficacy profiles in patients with mild to moderate Alzheimer"s disease (AD). Donepezil 75-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 23782591-1 2013 BACKGROUND: The class of acetylcholinesterase inhibitors (ChEI), including donepezil, rivastigmine, and galantamine, have similar efficacy profiles in patients with mild to moderate Alzheimer"s disease (AD). Rivastigmine 86-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 23782591-1 2013 BACKGROUND: The class of acetylcholinesterase inhibitors (ChEI), including donepezil, rivastigmine, and galantamine, have similar efficacy profiles in patients with mild to moderate Alzheimer"s disease (AD). Galantamine 104-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 23590426-0 2013 Real-time fluorometric assay for acetylcholinesterase activity and inhibitor screening through the pyrene probe monomer-excimer transition. pyrene 99-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 23557940-1 2013 This study was designed to determine the effect of a potent subcutaneously injected acetylcholinesterase inhibitor, rivastigmine (6mg/animal), on the gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) release during inflammation induced by an intravenous lipopolysaccharide (LPS) (400ng/kg) injection in ewes during the follicular phase of the estrous cycle. Rivastigmine 116-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-104 23557940-3 2013 Rivastigmine decreased the acetylcholinesterase concentration in the blood plasma from 176.9+-9.5 to 99.3+-15.1mumol/min/ml. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 23475318-0 2013 Acetylcholinesterase immobilization on polyacrylamide/functionalized multi-walled carbon nanotube nanocomposite nanofibrous membrane. polyacrylamide 39-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 23475318-0 2013 Acetylcholinesterase immobilization on polyacrylamide/functionalized multi-walled carbon nanotube nanocomposite nanofibrous membrane. Carbon 82-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 23698772-13 2013 The proposed binding orientation of caffeine can interact with Trp86, and it can be stabilize by Tyr337 in comparison to the smaller Ala328 in the case of human BChE; thus, it can explain the lower binding affinity of caffeine for BChE with reference to AChE. Caffeine 36-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 254-258 23698772-13 2013 The proposed binding orientation of caffeine can interact with Trp86, and it can be stabilize by Tyr337 in comparison to the smaller Ala328 in the case of human BChE; thus, it can explain the lower binding affinity of caffeine for BChE with reference to AChE. Caffeine 218-226 acetylcholinesterase (Cartwright blood group) Homo sapiens 254-258 23494216-0 2013 Purification of acetylcholinesterase by 9-amino-1,2,3,4-tetrahydroacridine from human erythrocytes. Tacrine 40-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 23494216-8 2013 K(m), V(max), optimum pH and optimum temperature for acetylcholinesterase were found by means of graphics for acetylthiocholine iodide as the substrate. acetylthiocholine iodide 110-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 23494216-9 2013 The optimum pH and optimum temperature of the acetylcholinesterase were determined to be 7.4 and 25-35 C. The Michaelis-Menten constant (K(m)) for the hydrolysis of acetylthiocholine iodide was found to be 0.25 mM, and the V(max) was 0.090 mumol/mL/min. acetylthiocholine iodide 166-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 22940283-7 2013 Between 280 and 316K, catalytic studies of these enzymes were carried out using thiocholine esters: at the same temperature, the hAChE activity was systematically higher than the mAChE or hBChE ones. thiocholine esters 80-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-134 23511019-1 2013 A new series of flavonoid derivatives were designed, synthesized and evaluated as potential multifunctional AChE inhibitors against Alzheimer"s disease. Flavonoids 16-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 23426015-0 2013 AhR-mediated effects of dioxin on neuronal acetylcholinesterase expression in vitro. Dioxins 24-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-63 23426015-4 2013 OBJECTIVES: We investigated the action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on acetylcholinesterase (AChE), a key enzyme in cholinergic neurotransmission. Polychlorinated Dibenzodioxins 42-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 23426015-4 2013 OBJECTIVES: We investigated the action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on acetylcholinesterase (AChE), a key enzyme in cholinergic neurotransmission. Polychlorinated Dibenzodioxins 42-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 23426015-4 2013 OBJECTIVES: We investigated the action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on acetylcholinesterase (AChE), a key enzyme in cholinergic neurotransmission. Polychlorinated Dibenzodioxins 79-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 23426015-5 2013 METHODS: We used SK-N-SH human-derived neuronal cells to evaluate the effect of dioxin exposure on AChE. Dioxins 80-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 23426015-6 2013 RESULTS: We consistently found a significant decrease in enzymatic activity of AChE in cultured neurons treated with TCDD. Polychlorinated Dibenzodioxins 117-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 23426015-7 2013 We also found that, unlike organophosphate pesticides that directly act on the catalytic center of AChE, the suppressive effect of dioxin was through transcriptional regulation. Dioxins 131-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 23426015-8 2013 The addition of CH223191, an inhibitor of the aryl hydrocarbon receptor (AhR)-dependent pathway, counteracted the TCDD-induced suppression of AChE, suggesting involvement of the AhR-dependent pathway. 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide 16-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 23426015-8 2013 The addition of CH223191, an inhibitor of the aryl hydrocarbon receptor (AhR)-dependent pathway, counteracted the TCDD-induced suppression of AChE, suggesting involvement of the AhR-dependent pathway. Polychlorinated Dibenzodioxins 114-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 23426015-9 2013 The existence of putative dioxin-responsive element (DRE) consensus sequences in the human ACHE promoter region further supported this hypothesis. Dioxins 26-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 23426015-11 2013 CONCLUSIONS: In SK-N-SH cells, dioxin suppressed the activity of neuronal AChE via AhR-mediated transcriptional down-regulation. Dioxins 31-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 23567956-5 2013 These results in combination to their known AChE/BuChE inhibitory activities led us to propose these indolyl carbohydrazides as new multifunctional compounds against AD. indolyl carbohydrazides 101-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 23380204-4 2013 The strongest 5-lipoxygenase (5-LOX), acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition activities were obtained for the ethanol extract (IC50 values of 6.20, 14.83 and 2.65mg/l, respectively) and the best cytotoxic activity against MCF-7 cells was obtained for the methanol extract (IC50=31mg/l). Ethanol 144-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-58 23380204-4 2013 The strongest 5-lipoxygenase (5-LOX), acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition activities were obtained for the ethanol extract (IC50 values of 6.20, 14.83 and 2.65mg/l, respectively) and the best cytotoxic activity against MCF-7 cells was obtained for the methanol extract (IC50=31mg/l). Ethanol 144-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 23544614-6 2013 Second, acetylcholinesterase catalyzed the hydrolysis of myristoylcholine into tetradecanoic acid, which reduced the myristoylcholine concentration and led to faded color and fluorescence. Myristic Acid 79-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-28 23544614-6 2013 Second, acetylcholinesterase catalyzed the hydrolysis of myristoylcholine into tetradecanoic acid, which reduced the myristoylcholine concentration and led to faded color and fluorescence. myristoylcholine 117-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-28 23567119-4 2013 The IC50 profiles for Donepezil measured in vitro were found to be comparable between both colorimetric and electrochemical detection methods for the analysis of purified human erythrocyte-derived AChE (28+-7 nM by DPV; 26+-8 nM by Ellman"s method). diperoxovanadate 215-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-201 23379636-2 2013 Pyridonepezils 15-18 were found to be selective and moderately potent regarding the inhibition of hAChE, whereas quinolinodonepezils 19-21 were found to be poor inhibitors of hAChE. pyridonepezils 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-103 23379636-3 2013 The most potent and selective hAChE inhibitor was ethyl 6-(4-(1-benzylpiperidin-4-yl)butylamino)-5-cyano-2-methyl-4-phenylnicotinate (18) [IC(50) (hAChE) = 0.25 +- 0.02 muM]. ethyl 6-(4-(1-benzylpiperidin-4-yl)butylamino)-5-cyano-2-methyl-4-phenylnicotinate 50-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-35 23379636-3 2013 The most potent and selective hAChE inhibitor was ethyl 6-(4-(1-benzylpiperidin-4-yl)butylamino)-5-cyano-2-methyl-4-phenylnicotinate (18) [IC(50) (hAChE) = 0.25 +- 0.02 muM]. ethyl 6-(4-(1-benzylpiperidin-4-yl)butylamino)-5-cyano-2-methyl-4-phenylnicotinate 50-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-152 23379636-9 2013 The pyrazolo[3,4-b]quinolines 36 and 38 also prevented the upregulation of AChE induced by Abeta(1-42). pyrazolo[3,4-b]quinolines 4-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 23202341-0 2013 Acetylcholinesterase biosensor based on chitosan/prussian blue/multiwall carbon nanotubes/hollow gold nanospheres nanocomposite film by one-step electrodeposition. prussian 49-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 23202341-0 2013 Acetylcholinesterase biosensor based on chitosan/prussian blue/multiwall carbon nanotubes/hollow gold nanospheres nanocomposite film by one-step electrodeposition. Carbon 73-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 23202341-5 2013 Based on the inhibition of pesticides on the AChE activity, using malathion, chlorpyrifos, monocrotophos and carbofuran as model compounds, this biosensor showed a wide range, low detection limit, good reproducibility and high stability. Malathion 66-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 23202341-5 2013 Based on the inhibition of pesticides on the AChE activity, using malathion, chlorpyrifos, monocrotophos and carbofuran as model compounds, this biosensor showed a wide range, low detection limit, good reproducibility and high stability. Chlorpyrifos 77-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 23202341-5 2013 Based on the inhibition of pesticides on the AChE activity, using malathion, chlorpyrifos, monocrotophos and carbofuran as model compounds, this biosensor showed a wide range, low detection limit, good reproducibility and high stability. Monocrotophos 91-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 23202341-5 2013 Based on the inhibition of pesticides on the AChE activity, using malathion, chlorpyrifos, monocrotophos and carbofuran as model compounds, this biosensor showed a wide range, low detection limit, good reproducibility and high stability. Carbofuran 109-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 23399701-2 2013 Huperzine A (HupA) is a selective inhibitor of acetylcholinesterase (AChE) and has been shown to significantly reduce cognitive impairment in animal models of dementia. huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 23399701-2 2013 Huperzine A (HupA) is a selective inhibitor of acetylcholinesterase (AChE) and has been shown to significantly reduce cognitive impairment in animal models of dementia. huperzine A 13-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 23399701-8 2013 SIGNIFICANCE: Our data reinforce the idea that AChE inhibitors, particularly HupA, do not act exclusively on the acetylcholine balance. Acetylcholine 113-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 23435553-0 2013 Exploring the multifunctionality of thioflavin- and deferiprone-based molecules as acetylcholinesterase inhibitors for potential application in Alzheimer"s disease. thioflavin T 36-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 23435553-0 2013 Exploring the multifunctionality of thioflavin- and deferiprone-based molecules as acetylcholinesterase inhibitors for potential application in Alzheimer"s disease. Deferiprone 52-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 23480691-3 2013 Trigolutesin A (1) showed weak AChE inhibitory activity. trigolutesin a (1) 0-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 23179755-1 2013 Organophosphorus inhibitors (OP) of acetylcholinesterase (AChE) represent a group of highly toxic compounds. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 23435942-3 2013 Cholinesterase inhibitors enhance cholinergic transmission directly by inhibiting the enzyme acetylcholinesterase (AChE) which hydrolyses acetylcholine. Acetylcholine 93-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 23435942-5 2013 Therefore, AChE and BuChE inhibition have been documented as critical targets for the effective management of AD by an increase in the availability of acetylcholine in the brain regions and decrease in the Abeta deposition. Acetylcholine 151-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-15 23352838-0 2013 Polyproline tetramer organizing peptides in fetal bovine serum acetylcholinesterase. polyproline 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 23352838-10 2013 A search of the mammalian proteome database suggested that this assortment of polyproline peptides originated from at least 5 different precursor proteins, none of which were the ColQ or PRiMA of membrane-anchored AChE. polyproline 78-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-218 23352838-11 2013 To date, AChE and BChE are the only proteins known that include polyproline tetramer organizing peptides in their tetrameric structure. polyproline 64-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 23534424-0 2013 LC-MS/MS approaches for the assay of bis-quaternary pyridinium oximes used as AChE reactivators in biological matrices. bis-quaternary pyridinium oximes 37-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 23534424-1 2013 BACKGROUND: Extreme efforts are made for the structural diversification of oximes used as AChE reactivators. Oximes 75-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 23434223-0 2013 A one-pot domino synthesis and discovery of highly functionalized dihydrobenzo[b]thiophenes as AChE inhibitors. dihydrobenzo[b]thiophenes 66-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 23434223-3 2013 These compounds were evaluated for their acetylcholinesterase (AChE) inhibitory activity and 5-amino-2,7-bis(4-methoxyphenyl)-2,3-dihydrobenzo[b]thiophene-4,6-dicarbonitrile was found to be the most potent against AChE with IC50 4.16 mumol/L. 5-amino-2,7-bis(4-methoxyphenyl)-2,3-dihydrobenzo[b]thiophene-4,6-dicarbonitrile 93-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 23434223-3 2013 These compounds were evaluated for their acetylcholinesterase (AChE) inhibitory activity and 5-amino-2,7-bis(4-methoxyphenyl)-2,3-dihydrobenzo[b]thiophene-4,6-dicarbonitrile was found to be the most potent against AChE with IC50 4.16 mumol/L. 5-amino-2,7-bis(4-methoxyphenyl)-2,3-dihydrobenzo[b]thiophene-4,6-dicarbonitrile 93-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 23434223-3 2013 These compounds were evaluated for their acetylcholinesterase (AChE) inhibitory activity and 5-amino-2,7-bis(4-methoxyphenyl)-2,3-dihydrobenzo[b]thiophene-4,6-dicarbonitrile was found to be the most potent against AChE with IC50 4.16 mumol/L. 5-amino-2,7-bis(4-methoxyphenyl)-2,3-dihydrobenzo[b]thiophene-4,6-dicarbonitrile 93-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 214-218 23453838-0 2013 Synthesis and anti-acetylcholinesterase properties of novel beta- and gamma-substituted alkoxy organophosphonates. substituted alkoxy organophosphonates 76-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 23453838-1 2013 Activated organophosphate (OP) insecticides and chemical agents inhibit acetylcholinesterase (AChE) to form OP-AChE adducts. Organophosphates 10-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-92 23453838-1 2013 Activated organophosphate (OP) insecticides and chemical agents inhibit acetylcholinesterase (AChE) to form OP-AChE adducts. Organophosphates 10-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 23453838-1 2013 Activated organophosphate (OP) insecticides and chemical agents inhibit acetylcholinesterase (AChE) to form OP-AChE adducts. Organophosphates 10-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 23453838-4 2013 The beta-fluoroethoxy methylphosphonate analog (R=Me, Z=F, n=2) was the most potent anti-AChE compound comparable (ki ~6 x 10(6)M(-1)min(-1)) to paraoxon against EEAChE. beta-fluoroethoxy methylphosphonate 4-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 23408070-4 2013 Donepezil, galantamine and rivastigmine are acetylcholinesterase inhibitors with different pharmacodynamic and pharmacokinetic profiles. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 23408070-4 2013 Donepezil, galantamine and rivastigmine are acetylcholinesterase inhibitors with different pharmacodynamic and pharmacokinetic profiles. Galantamine 11-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 23408070-4 2013 Donepezil, galantamine and rivastigmine are acetylcholinesterase inhibitors with different pharmacodynamic and pharmacokinetic profiles. Rivastigmine 27-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 23408070-5 2013 Donepezil inhibits selectively the acetylcholinesterase and has a long elimination half-life (t(1/2)) of 70 h. Galantamine is also a selective acetylcholinesterase inhibitor, but also modulates presynaptic nicotinic receptors. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 23408070-5 2013 Donepezil inhibits selectively the acetylcholinesterase and has a long elimination half-life (t(1/2)) of 70 h. Galantamine is also a selective acetylcholinesterase inhibitor, but also modulates presynaptic nicotinic receptors. Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 23408070-5 2013 Donepezil inhibits selectively the acetylcholinesterase and has a long elimination half-life (t(1/2)) of 70 h. Galantamine is also a selective acetylcholinesterase inhibitor, but also modulates presynaptic nicotinic receptors. Galantamine 111-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 23408070-5 2013 Donepezil inhibits selectively the acetylcholinesterase and has a long elimination half-life (t(1/2)) of 70 h. Galantamine is also a selective acetylcholinesterase inhibitor, but also modulates presynaptic nicotinic receptors. Galantamine 111-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 23408070-7 2013 Rivastigmine is a so-called "pseudo-irreversible" inhibitor of acetylcholinesterase and butyrylcholinesterase. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 23408070-14 2013 Moreover, polymorphisms in genes of the cholinergic markers acetylcholinesterase, butyrylcholinesterase, choline acetyltransferase and paraoxonase were found to be associated with better clinical response to acetylcholinesterase inhibitors. Choline 40-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 23408070-14 2013 Moreover, polymorphisms in genes of the cholinergic markers acetylcholinesterase, butyrylcholinesterase, choline acetyltransferase and paraoxonase were found to be associated with better clinical response to acetylcholinesterase inhibitors. Choline 40-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-228 23376249-0 2013 Synthesis and biological evaluation of 1,3,4-thiadiazole analogues as novel AChE and BuChE inhibitors. 1,3,4-thiadiazole 39-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-80 23422935-1 2013 A novel series of tacrine-lophine hybrids was synthesized and tested for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) with IC50 in the nanomolar concentration scale. Tacrine 18-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-118 23422935-1 2013 A novel series of tacrine-lophine hybrids was synthesized and tested for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) with IC50 in the nanomolar concentration scale. Tacrine 18-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 23422935-1 2013 A novel series of tacrine-lophine hybrids was synthesized and tested for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) with IC50 in the nanomolar concentration scale. lophine 26-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-118 23422935-1 2013 A novel series of tacrine-lophine hybrids was synthesized and tested for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) with IC50 in the nanomolar concentration scale. lophine 26-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-124 23454517-1 2013 A novel series of tacrine-selegiline hybrids was synthesised and evaluated for application as inhibitors of cholinesterase (AChE/BuChE) and monoamine oxidase (MAO-A/B). Tacrine 18-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 23454517-1 2013 A novel series of tacrine-selegiline hybrids was synthesised and evaluated for application as inhibitors of cholinesterase (AChE/BuChE) and monoamine oxidase (MAO-A/B). Selegiline 26-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 22407886-5 2013 Results indicate that 20 microm ethopropazine can be successfully used for the accurate measurement of AChE activity in blood from humans as well as animals. profenamine 32-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 23500628-0 2013 3D-QSAR studies of azaoxoisoaporphine, oxoaporphine, and oxoisoaporphine derivatives as anti-AChE and anti-AD agents by the CoMFA method. azaoxoisoaporphine 19-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 23500628-0 2013 3D-QSAR studies of azaoxoisoaporphine, oxoaporphine, and oxoisoaporphine derivatives as anti-AChE and anti-AD agents by the CoMFA method. oxoaporphine 39-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 23500628-0 2013 3D-QSAR studies of azaoxoisoaporphine, oxoaporphine, and oxoisoaporphine derivatives as anti-AChE and anti-AD agents by the CoMFA method. oxoisoaporphine 22-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 23500628-1 2013 In the present study, a series of novel azaoxoisoaporphine derivatives were reported and their inhibitory activities toward acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and Abeta aggregation were evaluated. azaoxoisoaporphine 40-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 23500628-1 2013 In the present study, a series of novel azaoxoisoaporphine derivatives were reported and their inhibitory activities toward acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and Abeta aggregation were evaluated. azaoxoisoaporphine 40-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 22975155-7 2013 Computational molecular modeling of RS41A and RS194B interactions with VX inhibited hAChE, bound reversibly in Michaelis type complex and covalently in the pentacoordinate reaction intermediate suggests that the faster reactivation reaction is a consequence of a tighter RS194B interactions with hAChE peripheral site (PAS) residues, in particular with D74, resulting in lower interaction energies for formation of both the binding and reactivation states. Aminosalicylic Acid 319-322 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-89 22975155-7 2013 Computational molecular modeling of RS41A and RS194B interactions with VX inhibited hAChE, bound reversibly in Michaelis type complex and covalently in the pentacoordinate reaction intermediate suggests that the faster reactivation reaction is a consequence of a tighter RS194B interactions with hAChE peripheral site (PAS) residues, in particular with D74, resulting in lower interaction energies for formation of both the binding and reactivation states. d74 353-356 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-89 22982773-0 2013 A common mechanism for resistance to oxime reactivation of acetylcholinesterase inhibited by organophosphorus compounds. Oximes 37-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 22982773-0 2013 A common mechanism for resistance to oxime reactivation of acetylcholinesterase inhibited by organophosphorus compounds. organophosphorus 93-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 22982773-1 2013 Administration of oxime therapy is currently the standard approach used to reverse the acute toxicity of organophosphorus (OP) compounds, which is usually attributed to OP inhibition of acetylcholinesterase (AChE). Oximes 18-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-206 22982773-1 2013 Administration of oxime therapy is currently the standard approach used to reverse the acute toxicity of organophosphorus (OP) compounds, which is usually attributed to OP inhibition of acetylcholinesterase (AChE). Oximes 18-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-212 22982773-1 2013 Administration of oxime therapy is currently the standard approach used to reverse the acute toxicity of organophosphorus (OP) compounds, which is usually attributed to OP inhibition of acetylcholinesterase (AChE). organophosphorus 105-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-206 22982773-1 2013 Administration of oxime therapy is currently the standard approach used to reverse the acute toxicity of organophosphorus (OP) compounds, which is usually attributed to OP inhibition of acetylcholinesterase (AChE). organophosphorus 105-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-212 22982773-2 2013 Rate constants for reactivation of OP-inhibited AChE by even the best oximes, such as HI-6 and obidoxime, can vary >100-fold between OP-AChE conjugates that are easily reactivated and those that are difficult to reactivate. Oximes 70-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 22982773-2 2013 Rate constants for reactivation of OP-inhibited AChE by even the best oximes, such as HI-6 and obidoxime, can vary >100-fold between OP-AChE conjugates that are easily reactivated and those that are difficult to reactivate. Oximes 70-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 22982773-2 2013 Rate constants for reactivation of OP-inhibited AChE by even the best oximes, such as HI-6 and obidoxime, can vary >100-fold between OP-AChE conjugates that are easily reactivated and those that are difficult to reactivate. asoxime chloride 86-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 22982773-2 2013 Rate constants for reactivation of OP-inhibited AChE by even the best oximes, such as HI-6 and obidoxime, can vary >100-fold between OP-AChE conjugates that are easily reactivated and those that are difficult to reactivate. asoxime chloride 86-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 22982773-2 2013 Rate constants for reactivation of OP-inhibited AChE by even the best oximes, such as HI-6 and obidoxime, can vary >100-fold between OP-AChE conjugates that are easily reactivated and those that are difficult to reactivate. Obidoxime Chloride 95-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 22982773-2 2013 Rate constants for reactivation of OP-inhibited AChE by even the best oximes, such as HI-6 and obidoxime, can vary >100-fold between OP-AChE conjugates that are easily reactivated and those that are difficult to reactivate. Obidoxime Chloride 95-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 22982773-3 2013 To gain a better understanding of this oxime specificity problem for future design of improved reactivators, we conducted a QSAR analysis for oxime reactivation of AChE inhibited by OP agents and their analogues. Oximes 39-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 22982773-3 2013 To gain a better understanding of this oxime specificity problem for future design of improved reactivators, we conducted a QSAR analysis for oxime reactivation of AChE inhibited by OP agents and their analogues. Oximes 142-147 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-168 23475318-1 2013 In this work, polyacrylamide/multi-walled carbon nanotubes (MWCNT) solution is electrospun to nanocomposite nanofibrous membranes for acetylcholinesterase enzyme immobilization. polyacrylamide 14-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 23475318-1 2013 In this work, polyacrylamide/multi-walled carbon nanotubes (MWCNT) solution is electrospun to nanocomposite nanofibrous membranes for acetylcholinesterase enzyme immobilization. Carbon 42-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 23376121-0 2013 Catalytic-site conformational equilibrium in nerve-agent adducts of acetylcholinesterase: possible implications for the HI-6 antidote substrate specificity. asoxime chloride 120-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 23376121-1 2013 Nerve agents such as tabun, cyclosarin and Russian VX inhibit the essential enzyme acetylcholinesterase (AChE) by organophosphorylating the catalytic serine residue. tabun 21-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 23376121-1 2013 Nerve agents such as tabun, cyclosarin and Russian VX inhibit the essential enzyme acetylcholinesterase (AChE) by organophosphorylating the catalytic serine residue. tabun 21-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 23376121-1 2013 Nerve agents such as tabun, cyclosarin and Russian VX inhibit the essential enzyme acetylcholinesterase (AChE) by organophosphorylating the catalytic serine residue. cyclohexyl methylphosphonofluoridate 28-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 23376121-1 2013 Nerve agents such as tabun, cyclosarin and Russian VX inhibit the essential enzyme acetylcholinesterase (AChE) by organophosphorylating the catalytic serine residue. cyclohexyl methylphosphonofluoridate 28-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 23376121-1 2013 Nerve agents such as tabun, cyclosarin and Russian VX inhibit the essential enzyme acetylcholinesterase (AChE) by organophosphorylating the catalytic serine residue. Serine 150-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 23376121-1 2013 Nerve agents such as tabun, cyclosarin and Russian VX inhibit the essential enzyme acetylcholinesterase (AChE) by organophosphorylating the catalytic serine residue. Serine 150-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 23376121-5 2013 The interaction between HI-6 and tabun-adducts of AChE were subsequently investigated using a combination of time resolved fluorescence spectroscopy and X-ray crystallography. asoxime chloride 24-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 23376121-6 2013 Our findings show that HI-6 binds to tabun inhibited Homo sapiens AChE (hAChE) with an IC50 value of 300muM and suggest that the reactive nucleophilic moiety of HI-6 is excluded from the phosphorus atom of tabun. asoxime chloride 23-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 23376121-6 2013 Our findings show that HI-6 binds to tabun inhibited Homo sapiens AChE (hAChE) with an IC50 value of 300muM and suggest that the reactive nucleophilic moiety of HI-6 is excluded from the phosphorus atom of tabun. asoxime chloride 23-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-77 23376121-6 2013 Our findings show that HI-6 binds to tabun inhibited Homo sapiens AChE (hAChE) with an IC50 value of 300muM and suggest that the reactive nucleophilic moiety of HI-6 is excluded from the phosphorus atom of tabun. asoxime chloride 161-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 23376121-6 2013 Our findings show that HI-6 binds to tabun inhibited Homo sapiens AChE (hAChE) with an IC50 value of 300muM and suggest that the reactive nucleophilic moiety of HI-6 is excluded from the phosphorus atom of tabun. asoxime chloride 161-165 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-77 23376121-6 2013 Our findings show that HI-6 binds to tabun inhibited Homo sapiens AChE (hAChE) with an IC50 value of 300muM and suggest that the reactive nucleophilic moiety of HI-6 is excluded from the phosphorus atom of tabun. Phosphorus 187-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 23376121-6 2013 Our findings show that HI-6 binds to tabun inhibited Homo sapiens AChE (hAChE) with an IC50 value of 300muM and suggest that the reactive nucleophilic moiety of HI-6 is excluded from the phosphorus atom of tabun. Phosphorus 187-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-77 23523385-4 2013 ACh accumulates due to OP inhibition of acetylcholinesterase (AChE), the enzyme that hydrolyzes ACh. Acetylcholine 0-3 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 23116458-8 2013 Erythrocyte AChE was inhibited by a total of 33%, 46%, and 62% after 2 weeks of 3.6 mg, 7.2 mg and 10.8 mg MSF, respectively. methanesulfonyl fluoride 107-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-16 23098644-1 2013 Acetylcholinesterase inhibitors (AChEIs) are the most widely used symptomatic treatment for mild to severe Alzheimer"s disease (AD) patients, while N-methyl-d-aspartic acid (NMDA) receptor antagonist memantine is licensed for use in moderate to severe AD patients. Memantine 200-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24179466-1 2013 Acetylcholinesterase is involved in the termination of impulse transmission by rapid hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the central and peripheral nervous systems. Acetylcholine 120-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24179466-6 2013 Subsequently, mechanism of irreversible acetylcholinesterase inhibition induced by organophosphorus compounds (insecticides and nerve agents), and their specific and nonspecific toxic effects are described, as well as irreversible inhibitors having pharmacological implementation. organophosphorus 83-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 23501115-4 2013 Besides, compounds showed higher activity of inhibiting AChE-induced amyloid-beta (Abeta) aggregation than curcumin, higher anti-oxidative activity than Trolox, and could also be good metal chelators. Curcumin 107-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 23501115-4 2013 Besides, compounds showed higher activity of inhibiting AChE-induced amyloid-beta (Abeta) aggregation than curcumin, higher anti-oxidative activity than Trolox, and could also be good metal chelators. 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 153-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 23501115-4 2013 Besides, compounds showed higher activity of inhibiting AChE-induced amyloid-beta (Abeta) aggregation than curcumin, higher anti-oxidative activity than Trolox, and could also be good metal chelators. Metals 184-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 23653426-1 2013 OBJECTIVE: Chronic use of the acetylcholinesterase inhibitor donepezil has been found to improve mood or to induce mania/hypomania in many neuropsychiatric patients with altered cholinergic and dopaminergic tone. Donepezil 61-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 23247598-3 2013 The acetylcholinesterase (AChE), essential enzyme for the regulation of turnover of acetylcholine, can be considered the most important biochemical indicator of cholinergic signaling in the nervous system. Acetylcholine 4-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-30 23802426-0 2013 Design, synthesis, and biological evaluation of acetophenone derivatives as dual binding acetylcholinesterase inhibitors. acetophenone 48-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-109 23802426-1 2013 As part of a project aimed at developing new agents for potential application in Alzheimer"s disease, a new series of acetophenone derivatives which possess alkylamine side chains were designed, synthesized and assayed as acetylcholinesterase (AChE) inhibitors that could simultaneously bind to the peripheral and catalytic sites of the enzyme. acetophenone 118-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 222-242 23802426-1 2013 As part of a project aimed at developing new agents for potential application in Alzheimer"s disease, a new series of acetophenone derivatives which possess alkylamine side chains were designed, synthesized and assayed as acetylcholinesterase (AChE) inhibitors that could simultaneously bind to the peripheral and catalytic sites of the enzyme. acetophenone 118-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 244-248 23802426-1 2013 As part of a project aimed at developing new agents for potential application in Alzheimer"s disease, a new series of acetophenone derivatives which possess alkylamine side chains were designed, synthesized and assayed as acetylcholinesterase (AChE) inhibitors that could simultaneously bind to the peripheral and catalytic sites of the enzyme. alkylamine 157-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 222-242 23622085-5 2013 The preliminary structure-activity indicated that: (i) The alkoxy or alkenoxy substituents in the position 3 of xanthone have a positive influence on the inhibition potency; (ii) types of dialkylamine methyl in position 2 of xanthone affected cholinesterase activities and AChE/BuChE selectivity. xanthone 112-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 273-277 23622085-5 2013 The preliminary structure-activity indicated that: (i) The alkoxy or alkenoxy substituents in the position 3 of xanthone have a positive influence on the inhibition potency; (ii) types of dialkylamine methyl in position 2 of xanthone affected cholinesterase activities and AChE/BuChE selectivity. dialkylamine 188-200 acetylcholinesterase (Cartwright blood group) Homo sapiens 273-277 23622085-8 2013 CONCLUSIONS: This study suggested that 1, 3-dihydroxyxanthone Mannich base derivatives were potential dual inhibitors of both AChE and BuChE, which may be considered as a kind of novel drug candidates for treatment of AD. 1, 3-dihydroxyxanthone mannich base 39-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 23544614-0 2013 Colorimetric and fluorometric assays based on conjugated polydiacetylene supramolecules for screening acetylcholinesterase and its inhibitors. polydiacetylene 57-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 23544614-6 2013 Second, acetylcholinesterase catalyzed the hydrolysis of myristoylcholine into tetradecanoic acid, which reduced the myristoylcholine concentration and led to faded color and fluorescence. myristoylcholine 57-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 8-28 23500628-3 2013 By 3D-QSAR studies, we constructed a reliable CoMFA model (q(2)=0.856 and r(2)=0.986) based on the inhibitory activities toward AChE and discovered key information on structure and anti-AChE activities among the azaoxoisoaporphine, oxoaporphine, and oxoisoaporphine derivatives. azaoxoisoaporphine 212-230 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 23500628-3 2013 By 3D-QSAR studies, we constructed a reliable CoMFA model (q(2)=0.856 and r(2)=0.986) based on the inhibitory activities toward AChE and discovered key information on structure and anti-AChE activities among the azaoxoisoaporphine, oxoaporphine, and oxoisoaporphine derivatives. azaoxoisoaporphine 212-230 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 23500628-3 2013 By 3D-QSAR studies, we constructed a reliable CoMFA model (q(2)=0.856 and r(2)=0.986) based on the inhibitory activities toward AChE and discovered key information on structure and anti-AChE activities among the azaoxoisoaporphine, oxoaporphine, and oxoisoaporphine derivatives. oxoaporphine 232-244 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 23500628-3 2013 By 3D-QSAR studies, we constructed a reliable CoMFA model (q(2)=0.856 and r(2)=0.986) based on the inhibitory activities toward AChE and discovered key information on structure and anti-AChE activities among the azaoxoisoaporphine, oxoaporphine, and oxoisoaporphine derivatives. oxoaporphine 232-244 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 23500628-3 2013 By 3D-QSAR studies, we constructed a reliable CoMFA model (q(2)=0.856 and r(2)=0.986) based on the inhibitory activities toward AChE and discovered key information on structure and anti-AChE activities among the azaoxoisoaporphine, oxoaporphine, and oxoisoaporphine derivatives. oxoisoaporphine 215-230 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 23500628-3 2013 By 3D-QSAR studies, we constructed a reliable CoMFA model (q(2)=0.856 and r(2)=0.986) based on the inhibitory activities toward AChE and discovered key information on structure and anti-AChE activities among the azaoxoisoaporphine, oxoaporphine, and oxoisoaporphine derivatives. oxoisoaporphine 215-230 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 23500628-5 2013 The statistically significant and physically meaningful 3D-QSAR/CoMFA model provided better insight into understanding the inhibitory behaviors of those chemicals, which may provide useful information for the rational molecular design of azaoxoisoaporphine derivatives anti-AChE and anti-AD agents. azaoxoisoaporphine 238-256 acetylcholinesterase (Cartwright blood group) Homo sapiens 274-278 22827894-0 2013 Structural requirements for effective oximes--evaluation of kinetic in vitro data with phosphylated human AChE and structurally different oximes. Oximes 38-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 22827894-1 2013 Treatment of poisoning by various organophosphorus (OP) nerve agents with established acetylcholinesterase (AChE) reactivators (oximes) is insufficient. Oximes 128-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 22827894-1 2013 Treatment of poisoning by various organophosphorus (OP) nerve agents with established acetylcholinesterase (AChE) reactivators (oximes) is insufficient. Oximes 128-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 22827894-4 2013 The crucial mechanism of action of oximes is the reactivation of phosphylated AChE. Oximes 35-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 22827894-6 2013 It was tempting to evaluate the reactivation kinetics of a series of oximes with various OP inhibitors performed under identical experimental conditions in order to get insight into structural requirements for adequate affinity and reactivity towards inhibited AChE. Oximes 69-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 261-265 22827894-7 2013 The determination of reactivation rate constants with bispyridinium oximes having different linkers, bearing oxime group(s) at different positions and having in part additional substituents revealed that (a) the reactivating potency was dependent on the position of the oxime groups and of additional substituents, (b) small modifications of the oxime structure had an in part marked effect on the kinetic properties and (c) no single oxime had an adequate reactivating potency with AChE inhibited by structurally different OP. bispyridinium oximes 54-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 483-487 22827894-7 2013 The determination of reactivation rate constants with bispyridinium oximes having different linkers, bearing oxime group(s) at different positions and having in part additional substituents revealed that (a) the reactivating potency was dependent on the position of the oxime groups and of additional substituents, (b) small modifications of the oxime structure had an in part marked effect on the kinetic properties and (c) no single oxime had an adequate reactivating potency with AChE inhibited by structurally different OP. Oximes 68-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 483-487 23047024-1 2013 Organophosphorus compounds (OPs) and oximes may interfere with other molecules than AChE in the living systems, affecting in this way various cellular processes and underlying mechanisms. Organophosphorus Compounds 0-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 23047024-1 2013 Organophosphorus compounds (OPs) and oximes may interfere with other molecules than AChE in the living systems, affecting in this way various cellular processes and underlying mechanisms. Organophosphorus Compounds 28-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 23047024-1 2013 Organophosphorus compounds (OPs) and oximes may interfere with other molecules than AChE in the living systems, affecting in this way various cellular processes and underlying mechanisms. Oximes 37-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 84-88 23047027-0 2013 Hydrolysis of low concentrations of the acetylthiocholine analogs acetyl(homo)thiocholine and acetyl(nor)thiocholine by acetylcholinesterase may be limited by selective gating at the enzyme peripheral site. Acetylthiocholine 40-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 23047027-0 2013 Hydrolysis of low concentrations of the acetylthiocholine analogs acetyl(homo)thiocholine and acetyl(nor)thiocholine by acetylcholinesterase may be limited by selective gating at the enzyme peripheral site. acetyl(homo)thiocholine 66-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 23047027-0 2013 Hydrolysis of low concentrations of the acetylthiocholine analogs acetyl(homo)thiocholine and acetyl(nor)thiocholine by acetylcholinesterase may be limited by selective gating at the enzyme peripheral site. acetyl(nor)thiocholine 94-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 23047027-1 2013 Hydrolysis of acetylcholine by acetylcholinesterase (AChE) is extremely rapid, with a second-order hydrolysis rate constant k(E) (often denoted k(cat)/K(M)) that approaches 10(8) M(-1) s(-1). Acetylcholine 14-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 23047027-1 2013 Hydrolysis of acetylcholine by acetylcholinesterase (AChE) is extremely rapid, with a second-order hydrolysis rate constant k(E) (often denoted k(cat)/K(M)) that approaches 10(8) M(-1) s(-1). Acetylcholine 14-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 22982773-4 2013 Our objective was to identify common mechanism(s) among OP-AChE conjugates of phosphates, phosphonates and phosphoramidates that result in resistance to oxime reactivation. Phosphates 78-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 22982773-4 2013 Our objective was to identify common mechanism(s) among OP-AChE conjugates of phosphates, phosphonates and phosphoramidates that result in resistance to oxime reactivation. Organophosphonates 90-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 22982773-4 2013 Our objective was to identify common mechanism(s) among OP-AChE conjugates of phosphates, phosphonates and phosphoramidates that result in resistance to oxime reactivation. phosphoramidic acid 107-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 22982773-4 2013 Our objective was to identify common mechanism(s) among OP-AChE conjugates of phosphates, phosphonates and phosphoramidates that result in resistance to oxime reactivation. Oximes 153-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 22982773-5 2013 Our evaluation of oxime reactivation of AChE inhibited by a sarin analogue, O-methyl isopropylphosphonofluoridate, or a cyclosarin analogue, O-methyl cyclohexylphosphonofluoridate, indicated that AChE inhibited by these analogues was at least 70-fold more difficult to reactivate than AChE inhibited by sarin or cyclosarin. Oximes 18-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 22982773-5 2013 Our evaluation of oxime reactivation of AChE inhibited by a sarin analogue, O-methyl isopropylphosphonofluoridate, or a cyclosarin analogue, O-methyl cyclohexylphosphonofluoridate, indicated that AChE inhibited by these analogues was at least 70-fold more difficult to reactivate than AChE inhibited by sarin or cyclosarin. Oximes 18-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 196-200 22982773-5 2013 Our evaluation of oxime reactivation of AChE inhibited by a sarin analogue, O-methyl isopropylphosphonofluoridate, or a cyclosarin analogue, O-methyl cyclohexylphosphonofluoridate, indicated that AChE inhibited by these analogues was at least 70-fold more difficult to reactivate than AChE inhibited by sarin or cyclosarin. Oximes 18-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 196-200 22982773-5 2013 Our evaluation of oxime reactivation of AChE inhibited by a sarin analogue, O-methyl isopropylphosphonofluoridate, or a cyclosarin analogue, O-methyl cyclohexylphosphonofluoridate, indicated that AChE inhibited by these analogues was at least 70-fold more difficult to reactivate than AChE inhibited by sarin or cyclosarin. o-methyl isopropylphosphonofluoridate 76-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 22982773-5 2013 Our evaluation of oxime reactivation of AChE inhibited by a sarin analogue, O-methyl isopropylphosphonofluoridate, or a cyclosarin analogue, O-methyl cyclohexylphosphonofluoridate, indicated that AChE inhibited by these analogues was at least 70-fold more difficult to reactivate than AChE inhibited by sarin or cyclosarin. cyclohexyl methylphosphonofluoridate 120-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 22982773-5 2013 Our evaluation of oxime reactivation of AChE inhibited by a sarin analogue, O-methyl isopropylphosphonofluoridate, or a cyclosarin analogue, O-methyl cyclohexylphosphonofluoridate, indicated that AChE inhibited by these analogues was at least 70-fold more difficult to reactivate than AChE inhibited by sarin or cyclosarin. o-methyl cyclohexylphosphonofluoridate 141-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 22982773-5 2013 Our evaluation of oxime reactivation of AChE inhibited by a sarin analogue, O-methyl isopropylphosphonofluoridate, or a cyclosarin analogue, O-methyl cyclohexylphosphonofluoridate, indicated that AChE inhibited by these analogues was at least 70-fold more difficult to reactivate than AChE inhibited by sarin or cyclosarin. o-methyl cyclohexylphosphonofluoridate 141-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 196-200 22982773-5 2013 Our evaluation of oxime reactivation of AChE inhibited by a sarin analogue, O-methyl isopropylphosphonofluoridate, or a cyclosarin analogue, O-methyl cyclohexylphosphonofluoridate, indicated that AChE inhibited by these analogues was at least 70-fold more difficult to reactivate than AChE inhibited by sarin or cyclosarin. o-methyl cyclohexylphosphonofluoridate 141-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 196-200 22982773-5 2013 Our evaluation of oxime reactivation of AChE inhibited by a sarin analogue, O-methyl isopropylphosphonofluoridate, or a cyclosarin analogue, O-methyl cyclohexylphosphonofluoridate, indicated that AChE inhibited by these analogues was at least 70-fold more difficult to reactivate than AChE inhibited by sarin or cyclosarin. cyclohexyl methylphosphonofluoridate 312-322 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 22982775-0 2013 On quantum mechanical--molecular mechanical (QM/MM) approaches to model hydrolysis of acetylcholine by acetylcholinesterase. Acetylcholine 86-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-123 22982775-1 2013 We re-visited the results of quantum mechanics--molecular mechanics (QM/MM) approaches aiming to construct the reaction energy profile for the acylation stage of acetylcholine hydrolysis by acetylcholinesterase. Acetylcholine 162-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 190-210 22989775-2 2013 New carbamates that are highly selective for inhibition of Anopheles gambiae acetylcholinesterase (AChE) over the human enzyme might be useful in continuing efforts to limit malaria transmission. Carbamates 4-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 23047022-1 2013 Although acetylcholinesterase (AChE) is primarily a hydrolytic enzyme, metabolising the neurotransmitter acetylcholine in cholinergic synapses, it also has some non-catalytic functions in the brain which are far less well characterised. Acetylcholine 9-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-35 23047022-3 2013 Since AChE does not possess a transmembrane domain, its anchorage in the membrane is established via the Proline Rich Membrane Anchor (PRiMA), a transmembrane protein. Proline 105-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-10 23073172-1 2013 We are evaluating a facilitative transport strategy to move oximes across the blood brain barrier (BBB) to reactivate inhibited brain acetylcholinesterase (AChE). Oximes 60-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-160 22944069-0 2013 Lithium treatment induces proteasomal degradation of over-expressed acetylcholinesterase (AChE-S) and inhibit GSK3beta. Lithium 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 23111374-0 2013 Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents. organophosphorus 105-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 23111374-2 2013 They cause an irreversible inhibition of acetylcholinesterase (AChE), by the formation of a covalent P-O bond with the catalytic serine. Serine 129-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 23073172-5 2013 Here we report the reactivation parameters for VX- and GB-inhibited human (Hu) AChE of the best SOx (13c) and our findings that the kinetics are similar to those of the parent oxime. 13c 101-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 22944069-0 2013 Lithium treatment induces proteasomal degradation of over-expressed acetylcholinesterase (AChE-S) and inhibit GSK3beta. Lithium 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-96 23073172-5 2013 Here we report the reactivation parameters for VX- and GB-inhibited human (Hu) AChE of the best SOx (13c) and our findings that the kinetics are similar to those of the parent oxime. Oximes 176-181 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 23111374-2 2013 They cause an irreversible inhibition of acetylcholinesterase (AChE), by the formation of a covalent P-O bond with the catalytic serine. Serine 129-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 23111374-4 2013 In this study, a series of seven new uncharged oximes reactivators have been synthesized and their in vitro ability to reactivate VX and tabun-inhibited human acetylcholinesterase (hAChE) has been evaluated. Oximes 47-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-179 22944069-4 2013 Cells treated with lithium exhibited rapid proteasomal degradation of AChE-S. Lithium 19-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-76 23111374-4 2013 In this study, a series of seven new uncharged oximes reactivators have been synthesized and their in vitro ability to reactivate VX and tabun-inhibited human acetylcholinesterase (hAChE) has been evaluated. Oximes 47-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-186 22944069-5 2013 Furthermore treatment of the cells with MG132, an inhibitor of the 26S proteasome, prevented the destabilizing effect of lithium on AChE-S. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 40-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-138 23085120-0 2013 Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating alpha7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade. bis(12)-hupyridone 0-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 23111374-6 2013 Regarding the reactivation of VX-inhibited hAChE, all compounds show a better reactivation potency than those of 2-PAM, nevertheless they are less efficient than obidoxime and HI-6. Pralidoxime Compounds 113-118 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-48 22944069-5 2013 Furthermore treatment of the cells with MG132, an inhibitor of the 26S proteasome, prevented the destabilizing effect of lithium on AChE-S. Lithium 121-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-138 23111374-6 2013 Regarding the reactivation of VX-inhibited hAChE, all compounds show a better reactivation potency than those of 2-PAM, nevertheless they are less efficient than obidoxime and HI-6. Obidoxime Chloride 162-171 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-48 23085120-0 2013 Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating alpha7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade. Glutamic Acid 77-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 23085120-1 2013 Bis(12)-hupyridone (B12H), derived from the Chinese medicinal component huperzine A, was originally designed as a novel acetylcholinesterase (AChE) inhibitor. bis(12)-hupyridone 0-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 23111374-6 2013 Regarding the reactivation of VX-inhibited hAChE, all compounds show a better reactivation potency than those of 2-PAM, nevertheless they are less efficient than obidoxime and HI-6. asoxime chloride 176-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-48 22944069-6 2013 Taken together, these findings suggest that regulation of AChE-S protein stability may be an important biological target of lithium therapy. Lithium 124-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-64 23111374-7 2013 Moreover, one of seven described compounds presents an ability to reactivate tabun-inhibited hAChE equivalent to those of 2-PAM. Pralidoxime Compounds 122-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-98 23085120-1 2013 Bis(12)-hupyridone (B12H), derived from the Chinese medicinal component huperzine A, was originally designed as a novel acetylcholinesterase (AChE) inhibitor. bis(12)-hupyridone 0-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 23085120-1 2013 Bis(12)-hupyridone (B12H), derived from the Chinese medicinal component huperzine A, was originally designed as a novel acetylcholinesterase (AChE) inhibitor. bis(12)-hupyridone 20-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 22960624-0 2013 Centrally acting oximes in reactivation of tabun-phosphoramidated AChE. Oximes 17-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 23085120-1 2013 Bis(12)-hupyridone (B12H), derived from the Chinese medicinal component huperzine A, was originally designed as a novel acetylcholinesterase (AChE) inhibitor. bis(12)-hupyridone 20-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 23085120-1 2013 Bis(12)-hupyridone (B12H), derived from the Chinese medicinal component huperzine A, was originally designed as a novel acetylcholinesterase (AChE) inhibitor. huperzine A 72-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 23085120-1 2013 Bis(12)-hupyridone (B12H), derived from the Chinese medicinal component huperzine A, was originally designed as a novel acetylcholinesterase (AChE) inhibitor. huperzine A 72-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 23123247-1 2013 Organophosphorus nerve agents are irreversible inhibitors of acetylcholinesterase. organophosphorus 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 22960624-1 2013 Organophosphates (OP) inhibit acetylcholinesterase (AChE, EC 3.1.1.7), both in peripheral tissues and central nervous system (CNS), causing adverse and sometimes fatal effects due to the accumulation of neurotransmitter acetylcholine (ACh). Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 23123251-2 2013 We focused on 4 EOHs of particular toxicological interest: acetylcholinesterase (AChE: acute neurotoxicity; cognition enhancement), butyrylcholinesterase (BChE: inhibition of drug metabolism and/or stoichiometric scavenging of EOH inhibitors; cognition enhancement), carboxylesterase (CaE: inhibition of drug metabolism and/or stoichiometric scavenging of EOH inhibitors), and neuropathy target esterase (NTE: delayed neurotoxicity, OPIDN). eohs 16-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 22960624-1 2013 Organophosphates (OP) inhibit acetylcholinesterase (AChE, EC 3.1.1.7), both in peripheral tissues and central nervous system (CNS), causing adverse and sometimes fatal effects due to the accumulation of neurotransmitter acetylcholine (ACh). Acetylcholine 30-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-56 22960624-2 2013 The currently used therapy, focusing on the reactivation of inhibited AChE, is limited to peripheral tissues because commonly used quaternary pyridinium oxime reactivators do not cross the blood brain barrier (BBB) at therapeutically relevant levels. quaternary pyridinium oxime 131-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 22960624-4 2013 The oxime RS150D [N-((1-(3-(2-((hydroxyimino)methyl)-1H-imidazol-1-yl)propyl)-1H-1,2,3-triazol-4-yl)methyl)benzamide] was highlighted as the most promising reactivator of the tabun-hAChE conjugate. Oximes 4-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-186 23529036-3 2013 The dichloromethane, ethanol and methanol extracts from the leaves of Rauvolfia reflexa showed potential acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities, with IC50 values in the 8.49 to 52.23 g/mL range. Methanol 33-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 22960624-4 2013 The oxime RS150D [N-((1-(3-(2-((hydroxyimino)methyl)-1H-imidazol-1-yl)propyl)-1H-1,2,3-triazol-4-yl)methyl)benzamide] was highlighted as the most promising reactivator of the tabun-hAChE conjugate. n-((1-(3-(2-((hydroxyimino)methyl)-1h-imidazol-1-yl)propyl)-1h-1,2,3-triazol-4-yl)methyl)benzamide 18-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 181-186 22960624-8 2013 The phosphoramidated-hAChE choline-binding site mutant Y337A showed three-times enhanced reactivation capacity with non-triazole imidazole containing aldoximes (RS113B, RS113A and RS115A) and acetamide derivative (RS194B) than with 2PAM. Choline 27-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-26 23529036-3 2013 The dichloromethane, ethanol and methanol extracts from the leaves of Rauvolfia reflexa showed potential acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities, with IC50 values in the 8.49 to 52.23 g/mL range. Methylene Chloride 4-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 22960624-8 2013 The phosphoramidated-hAChE choline-binding site mutant Y337A showed three-times enhanced reactivation capacity with non-triazole imidazole containing aldoximes (RS113B, RS113A and RS115A) and acetamide derivative (RS194B) than with 2PAM. triazole imidazole 120-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-26 23529036-3 2013 The dichloromethane, ethanol and methanol extracts from the leaves of Rauvolfia reflexa showed potential acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities, with IC50 values in the 8.49 to 52.23 g/mL range. Ethanol 21-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-131 22960624-8 2013 The phosphoramidated-hAChE choline-binding site mutant Y337A showed three-times enhanced reactivation capacity with non-triazole imidazole containing aldoximes (RS113B, RS113A and RS115A) and acetamide derivative (RS194B) than with 2PAM. acetamide 192-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-26 22975155-1 2013 A library of more than 200 novel uncharged oxime reactivators was used to select and refine lead reactivators of human acetylcholinesterase (hAChE) covalently conjugated with sarin, cyclosarin, VX, paraoxon and tabun. Oximes 43-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-146 22975155-1 2013 A library of more than 200 novel uncharged oxime reactivators was used to select and refine lead reactivators of human acetylcholinesterase (hAChE) covalently conjugated with sarin, cyclosarin, VX, paraoxon and tabun. Sarin 175-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-146 22975155-1 2013 A library of more than 200 novel uncharged oxime reactivators was used to select and refine lead reactivators of human acetylcholinesterase (hAChE) covalently conjugated with sarin, cyclosarin, VX, paraoxon and tabun. cyclohexyl methylphosphonofluoridate 182-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-146 22975155-1 2013 A library of more than 200 novel uncharged oxime reactivators was used to select and refine lead reactivators of human acetylcholinesterase (hAChE) covalently conjugated with sarin, cyclosarin, VX, paraoxon and tabun. Paraoxon 198-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-146 22975155-1 2013 A library of more than 200 novel uncharged oxime reactivators was used to select and refine lead reactivators of human acetylcholinesterase (hAChE) covalently conjugated with sarin, cyclosarin, VX, paraoxon and tabun. tabun 211-216 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-146 23398232-3 2013 Acetylcholinesterase (AChE) converts ACh to choline, which in turn is oxidized by choline oxidase (ChOx) to produce betaine and H2O2 that generates the reactive oxygen species (ROS). Acetylcholine 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 23017678-0 2013 Highly sensitive detection of organophosphorus pesticides by acetylcholinesterase-coated thin film bulk acoustic resonator mass-loading sensor. organophosphorus 30-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 23017678-1 2013 An acetylcholinesterase-coated thin film bulk acoustic resonator has been developed for the detection of organophosphorus pesticides. organophosphorus 105-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 3-23 23017678-4 2013 The detection is based on the inhibitory effects of organophosphorus compounds on the enzymatic activity of the acetylcholinesterase immobilized on one of the faces of the acoustic resonator. organophosphorus 52-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 23398232-3 2013 Acetylcholinesterase (AChE) converts ACh to choline, which in turn is oxidized by choline oxidase (ChOx) to produce betaine and H2O2 that generates the reactive oxygen species (ROS). Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 23398232-3 2013 Acetylcholinesterase (AChE) converts ACh to choline, which in turn is oxidized by choline oxidase (ChOx) to produce betaine and H2O2 that generates the reactive oxygen species (ROS). Betaine 116-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 23398232-3 2013 Acetylcholinesterase (AChE) converts ACh to choline, which in turn is oxidized by choline oxidase (ChOx) to produce betaine and H2O2 that generates the reactive oxygen species (ROS). Betaine 116-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 23398232-3 2013 Acetylcholinesterase (AChE) converts ACh to choline, which in turn is oxidized by choline oxidase (ChOx) to produce betaine and H2O2 that generates the reactive oxygen species (ROS). Hydrogen Peroxide 128-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 23398232-3 2013 Acetylcholinesterase (AChE) converts ACh to choline, which in turn is oxidized by choline oxidase (ChOx) to produce betaine and H2O2 that generates the reactive oxygen species (ROS). Hydrogen Peroxide 128-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 23398232-3 2013 Acetylcholinesterase (AChE) converts ACh to choline, which in turn is oxidized by choline oxidase (ChOx) to produce betaine and H2O2 that generates the reactive oxygen species (ROS). Reactive Oxygen Species 152-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 23398232-3 2013 Acetylcholinesterase (AChE) converts ACh to choline, which in turn is oxidized by choline oxidase (ChOx) to produce betaine and H2O2 that generates the reactive oxygen species (ROS). Reactive Oxygen Species 152-175 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 23398232-3 2013 Acetylcholinesterase (AChE) converts ACh to choline, which in turn is oxidized by choline oxidase (ChOx) to produce betaine and H2O2 that generates the reactive oxygen species (ROS). Reactive Oxygen Species 177-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 23398232-3 2013 Acetylcholinesterase (AChE) converts ACh to choline, which in turn is oxidized by choline oxidase (ChOx) to produce betaine and H2O2 that generates the reactive oxygen species (ROS). Reactive Oxygen Species 177-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 23330848-4 2013 The assay method was validated using the reference AChE inhibitors tacrine and galanthamine. Tacrine 67-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 23330848-4 2013 The assay method was validated using the reference AChE inhibitors tacrine and galanthamine. Galantamine 79-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 23379662-0 2013 In situ formation of metal coordination polymer: a strategy for fluorescence turn-on assay of acetylcholinesterase activity and inhibitor screening. Metals 21-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 23440190-5 2013 We applied this method to simulate the binding event of the anti-Alzheimer"s disease drug (-)-Huperzine A to its target acetylcholinesterase (AChE). huperzine A 94-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 120-140 23440190-5 2013 We applied this method to simulate the binding event of the anti-Alzheimer"s disease drug (-)-Huperzine A to its target acetylcholinesterase (AChE). huperzine A 94-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 23440190-8 2013 The method also provides atomic resolution information for the (-)-Huperzine A binding pathway, which may be useful in designing more potent AChE inhibitors. huperzine A 67-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 23459299-0 2013 New tacrine analogs as acetylcholinesterase inhibitors - theoretical study with chemometric analysis. Tacrine 4-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 23389781-0 2013 Synthesis and biological evaluation of some pyrazoline derivatives bearing a dithiocarbamate moiety as new cholinesterase inhibitors. pyrazoline 44-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-121 23389781-0 2013 Synthesis and biological evaluation of some pyrazoline derivatives bearing a dithiocarbamate moiety as new cholinesterase inhibitors. Dithiocarbamate 77-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-121 23389781-5 2013 Compounds effective on AChE carry the 2-dimethylaminoethyl moiety, which resembles the trimethylammonium group and the ethylene bridge of acetylcholine. dimethylaminoethyl 40-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 23389781-5 2013 Compounds effective on AChE carry the 2-dimethylaminoethyl moiety, which resembles the trimethylammonium group and the ethylene bridge of acetylcholine. Cetrimonium 87-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 23354570-4 2013 The AChE biosensor showed favorable affinity for acetylthiocholine chloride and catalyzed the hydrolysis of acetylthiocholine chloride with an apparent Michaelis-Menten constant of 134 muM to form thiocholine, which was then oxidized to produce a detectable and fast response. Acetylthiocholine chloride 49-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 23354570-4 2013 The AChE biosensor showed favorable affinity for acetylthiocholine chloride and catalyzed the hydrolysis of acetylthiocholine chloride with an apparent Michaelis-Menten constant of 134 muM to form thiocholine, which was then oxidized to produce a detectable and fast response. Acetylthiocholine chloride 108-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 23354570-4 2013 The AChE biosensor showed favorable affinity for acetylthiocholine chloride and catalyzed the hydrolysis of acetylthiocholine chloride with an apparent Michaelis-Menten constant of 134 muM to form thiocholine, which was then oxidized to produce a detectable and fast response. Thiocholine 55-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 23354570-5 2013 Based on the inhibition by pesticides of the enzymatic activity of AChE, detection of the amperometric response from thiocholine on the biosensor is a simple and effective way to biomonitor exposure to pesticides. Thiocholine 117-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 23389781-5 2013 Compounds effective on AChE carry the 2-dimethylaminoethyl moiety, which resembles the trimethylammonium group and the ethylene bridge of acetylcholine. ethylene 119-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 23379662-0 2013 In situ formation of metal coordination polymer: a strategy for fluorescence turn-on assay of acetylcholinesterase activity and inhibitor screening. Polymers 40-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-114 23389781-5 2013 Compounds effective on AChE carry the 2-dimethylaminoethyl moiety, which resembles the trimethylammonium group and the ethylene bridge of acetylcholine. Acetylcholine 138-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 23379662-1 2013 A novel method for the sensing of acetylcholinesterase (AChE) activity and inhibitor screening based on the formation of metal coordination polymer has been developed. Metals 121-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 23379662-1 2013 A novel method for the sensing of acetylcholinesterase (AChE) activity and inhibitor screening based on the formation of metal coordination polymer has been developed. Metals 121-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-60 23379662-3 2013 In the presence of AChE, ATCh was hydrolyzed to thiocholine and acetate. Acetylthiocholine 25-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 23379662-3 2013 In the presence of AChE, ATCh was hydrolyzed to thiocholine and acetate. Thiocholine 48-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 23379662-3 2013 In the presence of AChE, ATCh was hydrolyzed to thiocholine and acetate. Acetates 64-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 23379662-7 2013 In the presence of acetylcholinesterase, the positively charged metal coordination polymer newly formed in situ would interact with PVS, probe 1 monomer molecules were released, and a turn on fluorescence signal was detected. Metals 64-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 23274156-1 2013 This manuscript describes results related to the characterization of electrodes modified with a composite of acetylcholinesterase covalently bound to carbon nanotubes (CNT). Carbon 150-156 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-129 22734711-2 2013 In an attempt to find inhibitors for acetylcholinesterase (AChE), the Drug Bank Database and natural alkaloids with other known medicinal values were screened through a four-point pharmacophore built in this study. Alkaloids 101-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-57 22734711-2 2013 In an attempt to find inhibitors for acetylcholinesterase (AChE), the Drug Bank Database and natural alkaloids with other known medicinal values were screened through a four-point pharmacophore built in this study. Alkaloids 101-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-63 22829062-6 2013 Finally, AChE was immobilized with covalent binding via -COOH groups of L-cysteine onto the modified GCE. Carbonic Acid 57-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 22829062-6 2013 Finally, AChE was immobilized with covalent binding via -COOH groups of L-cysteine onto the modified GCE. Cysteine 72-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 22829062-7 2013 The AChE biosensor fabrication process was characterized by cyclic voltammetry and electrochemical impedance spectroscopy methods with the use of ferricyanide as an electrochemical redox indicator. hexacyanoferrate III 146-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 23610582-2 2013 Rivastigmine, an acetylcholinesterase inhibitor, has several common adverse effects, mainly involving the gastrointestinal tract, but few cardiovascular adverse effects have been reported. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 23369066-4 2013 The results of these studies showed the inhibitory capacity of some agonist cannabinoids with selectivity at AChE or BuChE enzymes. Cannabinoids 76-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 22684846-1 2013 Organophosphate (OP) and carbamate (CP) pesticides act by the inhibition of acetylcholinesterase (AChE). Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 22684846-1 2013 Organophosphate (OP) and carbamate (CP) pesticides act by the inhibition of acetylcholinesterase (AChE). Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 22684846-1 2013 Organophosphate (OP) and carbamate (CP) pesticides act by the inhibition of acetylcholinesterase (AChE). Carbamates 25-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 22684846-1 2013 Organophosphate (OP) and carbamate (CP) pesticides act by the inhibition of acetylcholinesterase (AChE). Carbamates 25-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 22684846-5 2013 Therefore we examined the effect of five different pesticides (carbaryl, carbofuran, parathion, demeton-S-methyl, and aldicarb) on AChE activity to determine whether combinations had an additive, synergistic, or antagonistic inhibitory effect. Carbaryl 63-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 22684846-5 2013 Therefore we examined the effect of five different pesticides (carbaryl, carbofuran, parathion, demeton-S-methyl, and aldicarb) on AChE activity to determine whether combinations had an additive, synergistic, or antagonistic inhibitory effect. demeton-S-methyl 96-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 23348103-4 2013 Contour map of variable coefficients showed that hydrogen bonding between the O atom in PO and the NH groups in acetylcholinesterase (AChE) played an important role in the interaction between OP and AChE. Hydrogen 49-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 23348103-4 2013 Contour map of variable coefficients showed that hydrogen bonding between the O atom in PO and the NH groups in acetylcholinesterase (AChE) played an important role in the interaction between OP and AChE. Hydrogen 49-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-203 23229229-0 2013 In vitro inhibitory profile of NDGA against AChE and its in silico structural modifications based on ADME profile. Masoprocol 31-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 23262302-5 2013 Bis-Mep was found to be a mixed-type inhibitor on electric eel AChE by enzyme kinetic study. bis(9)-normeptazinol 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 23229229-3 2013 AChE inhibitors such as rivastigmine, galantamine, physostigmine and huperzine are obtained from plants, indicating that plants can serve as a potential source for novel AChE inhibitors. Rivastigmine 24-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 23229229-3 2013 AChE inhibitors such as rivastigmine, galantamine, physostigmine and huperzine are obtained from plants, indicating that plants can serve as a potential source for novel AChE inhibitors. Rivastigmine 24-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 23229229-3 2013 AChE inhibitors such as rivastigmine, galantamine, physostigmine and huperzine are obtained from plants, indicating that plants can serve as a potential source for novel AChE inhibitors. Galantamine 38-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 23229229-3 2013 AChE inhibitors such as rivastigmine, galantamine, physostigmine and huperzine are obtained from plants, indicating that plants can serve as a potential source for novel AChE inhibitors. Physostigmine 51-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 23229229-3 2013 AChE inhibitors such as rivastigmine, galantamine, physostigmine and huperzine are obtained from plants, indicating that plants can serve as a potential source for novel AChE inhibitors. Physostigmine 51-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 23229229-3 2013 AChE inhibitors such as rivastigmine, galantamine, physostigmine and huperzine are obtained from plants, indicating that plants can serve as a potential source for novel AChE inhibitors. huperzine A 69-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 23229229-3 2013 AChE inhibitors such as rivastigmine, galantamine, physostigmine and huperzine are obtained from plants, indicating that plants can serve as a potential source for novel AChE inhibitors. huperzine A 69-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 22931533-2 2013 Galantamine is a reversible, competitive acetylcholinesterase (AChE) inhibitor and allosteric potentiating ligand of nicotinic acetylcholine receptors (nAChR-APL) that shares many common structural elements with morphinan-based opioids. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 22931533-2 2013 Galantamine is a reversible, competitive acetylcholinesterase (AChE) inhibitor and allosteric potentiating ligand of nicotinic acetylcholine receptors (nAChR-APL) that shares many common structural elements with morphinan-based opioids. Galantamine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 22931533-2 2013 Galantamine is a reversible, competitive acetylcholinesterase (AChE) inhibitor and allosteric potentiating ligand of nicotinic acetylcholine receptors (nAChR-APL) that shares many common structural elements with morphinan-based opioids. Acetylcholine 41-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 22931533-3 2013 The structurally diverse opioids codeine and eseroline, like galantamine, are also nAChR-APL that have greatly diminished affinity for AChE, representing potential lead compounds for selective nAChR-APL development. Codeine 33-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 22931533-3 2013 The structurally diverse opioids codeine and eseroline, like galantamine, are also nAChR-APL that have greatly diminished affinity for AChE, representing potential lead compounds for selective nAChR-APL development. eseroline 45-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 22931533-3 2013 The structurally diverse opioids codeine and eseroline, like galantamine, are also nAChR-APL that have greatly diminished affinity for AChE, representing potential lead compounds for selective nAChR-APL development. Galantamine 61-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 23353586-2 2013 The AD pathogenicity involved in AChE protein is mainly due to amyloid beta peptide aggregation, which is triggered specifically by peripheral anionic site (PAS) of AChE. Aminosalicylic Acid 157-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 23353586-2 2013 The AD pathogenicity involved in AChE protein is mainly due to amyloid beta peptide aggregation, which is triggered specifically by peripheral anionic site (PAS) of AChE. Aminosalicylic Acid 157-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 23353586-3 2013 In the present study, a workflow has been developed for the identification and prioritization of potential compounds that could interact not only with the catalytic site but also with the PAS of AChE. Aminosalicylic Acid 188-191 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 23353586-10 2013 The knowledge gained from this study, could lead to the discovery of potential AChE inhibitors that are highly specific for AD treatment as they are bivalent lead molecules endowed with dual binding ability for both catalytic site and PAS of AChE. Aminosalicylic Acid 235-238 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 23353586-10 2013 The knowledge gained from this study, could lead to the discovery of potential AChE inhibitors that are highly specific for AD treatment as they are bivalent lead molecules endowed with dual binding ability for both catalytic site and PAS of AChE. Aminosalicylic Acid 235-238 acetylcholinesterase (Cartwright blood group) Homo sapiens 242-246 23410111-1 2013 Organophosphate nerve agents and pesticides are potent inhibitors of acetylcholinesterase (AChE). Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 23410111-1 2013 Organophosphate nerve agents and pesticides are potent inhibitors of acetylcholinesterase (AChE). Organophosphates 0-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 23410111-2 2013 Although oxime nucleophiles can reactivate the AChE-phosphyl adduct, the adduct undergoes a reaction called aging. Oximes 9-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 23262302-6 2013 Molecular docking revealed that two "water bridges" located at the two wings of Bis-Mep stabilized its interaction with both catalytic and peripheral anionic sites of AChE. Water 37-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 23262302-6 2013 Molecular docking revealed that two "water bridges" located at the two wings of Bis-Mep stabilized its interaction with both catalytic and peripheral anionic sites of AChE. bis(9)-normeptazinol 80-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-171 23262302-8 2013 The maximal cognitive amelioration of Bis-Mep was achieved at 100 ng/kg, comparable with the effect of a reference drug Huperzine A at 1 mg/kg and also the relevant AChE inhibition in brain. bis(9)-normeptazinol 38-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 23262302-9 2013 These findings suggested that Bis-Mep might be a promising dual-binding AChE inhibitor for potential AD therapeutics. bis(9)-normeptazinol 30-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 23429378-1 2013 A structural series of 7-MEOTA-adamantylamine thioureas was designed, synthesized and evaluated as inhibitors of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE). 7-meota-adamantylamine thioureas 23-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-146 23447584-4 2013 In humans, however, pain responses can be modulated by spinal ACh, as evidenced by the increasingly used analgesic procedure (for postoperative and labor patients) consisting of the epidural injection of the acetylcholinesterase inhibitor neostigmine. Acetylcholine 62-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-228 23447584-4 2013 In humans, however, pain responses can be modulated by spinal ACh, as evidenced by the increasingly used analgesic procedure (for postoperative and labor patients) consisting of the epidural injection of the acetylcholinesterase inhibitor neostigmine. Neostigmine 239-250 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-228 23401542-5 2013 Administration of fluoxetine also increased AChE activity throughout the brain, with the greatest change in the hippocampus. Fluoxetine 18-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 23401542-8 2013 The behavioral changes due to shRNA-mediated knockdown of AChE were rescued by coinfusion of an shRNA-resistant AChE transgene into the hippocampus and reversed by systemic administration of fluoxetine. Fluoxetine 191-201 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 23401542-10 2013 The sensitivity of these effects to fluoxetine suggests that shRNA-mediated knockdown of hippocampal AChE represents a model for anxiety- and depression-like phenotypes. Fluoxetine 36-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 23445881-0 2013 5,6-Dimethoxybenzofuran-3-one derivatives: a novel series of dual Acetylcholinesterase/Butyrylcholinesterase inhibitors bearing benzyl pyridinium moiety. 5,6-dimethoxybenzofuran-3-one 0-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 23445881-0 2013 5,6-Dimethoxybenzofuran-3-one derivatives: a novel series of dual Acetylcholinesterase/Butyrylcholinesterase inhibitors bearing benzyl pyridinium moiety. benzyl pyridinium 128-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 23445881-3 2013 As a part of a research program to find a novel drug for treating Alzheimer disease, we have previously reported 6-alkoxybenzofuranone derivatives as potent acetylcholinesterase inhibitors. 6-alkoxybenzofuranone 113-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-177 23445881-4 2013 In continuation of our work, we would like to report the synthesis of 5,6-dimethoxy benzofuranone derivatives bearing a benzyl pyridinium moiety as dual Acetylcholinesterase/Butyrylcholinesterase inhibitors. 5,6-dimethoxy benzofuranone 70-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-173 23445881-4 2013 In continuation of our work, we would like to report the synthesis of 5,6-dimethoxy benzofuranone derivatives bearing a benzyl pyridinium moiety as dual Acetylcholinesterase/Butyrylcholinesterase inhibitors. benzyl pyridinium 120-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-173 23445881-13 2013 CONCLUSIONS: In this study, we presented a new series of benzofuranone-based derivatives having pyridinium moiety as potent dual acting Acetylcholinesterase/Butyrylcholinesterase inhibitors. 2-coumaranone 57-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 23445881-13 2013 CONCLUSIONS: In this study, we presented a new series of benzofuranone-based derivatives having pyridinium moiety as potent dual acting Acetylcholinesterase/Butyrylcholinesterase inhibitors. pyridine 96-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 23421685-2 2013 We report here the synthesis of a small library of novel sym-triazine compounds designed for targeted modulation of multiple pathologies related to AD, specifically human acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and Abeta aggregation. 1,3,5-TRIAZINE 57-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 171-191 23421685-2 2013 We report here the synthesis of a small library of novel sym-triazine compounds designed for targeted modulation of multiple pathologies related to AD, specifically human acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and Abeta aggregation. 1,3,5-TRIAZINE 57-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 193-197 23421685-3 2013 Rational targeting of AChE was achieved by the incorporation of acetylcholine substrate analogues into a sym-triazine core in either a mono-, di-, or trisubstituted regime. Acetylcholine 64-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 23421685-3 2013 Rational targeting of AChE was achieved by the incorporation of acetylcholine substrate analogues into a sym-triazine core in either a mono-, di-, or trisubstituted regime. 1,3,5-TRIAZINE 105-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 23339663-2 2013 TOCP is metabolized to cresyl saligenin phosphate (CBDP), a potent irreversible inhibitor of butyrylcholinesterase (BChE), a natural bioscavenger present in the bloodstream, and acetylcholinesterase (AChE), the off-switch at cholinergic synapses. 2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide 23-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-204 23339663-2 2013 TOCP is metabolized to cresyl saligenin phosphate (CBDP), a potent irreversible inhibitor of butyrylcholinesterase (BChE), a natural bioscavenger present in the bloodstream, and acetylcholinesterase (AChE), the off-switch at cholinergic synapses. 2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide 51-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 178-198 23339663-2 2013 TOCP is metabolized to cresyl saligenin phosphate (CBDP), a potent irreversible inhibitor of butyrylcholinesterase (BChE), a natural bioscavenger present in the bloodstream, and acetylcholinesterase (AChE), the off-switch at cholinergic synapses. 2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide 51-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-204 23339663-4 2013 Also, the inhibition of AChE by CBDP is unexpected, from a structural standpoint, i.e., considering the narrowness of AChE active site and the bulkiness of CBDP. 2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide 32-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 23339663-4 2013 Also, the inhibition of AChE by CBDP is unexpected, from a structural standpoint, i.e., considering the narrowness of AChE active site and the bulkiness of CBDP. 2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide 32-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 23339663-4 2013 Also, the inhibition of AChE by CBDP is unexpected, from a structural standpoint, i.e., considering the narrowness of AChE active site and the bulkiness of CBDP. 2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide 156-160 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 23339663-6 2013 The series of crystallographic snapshots reveals that AChE and BChE react with the opposite enantiomers and that an induced-fit rearrangement of Phe297 enlarges the active site of AChE upon CBDP binding. 2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide 190-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 23339663-6 2013 The series of crystallographic snapshots reveals that AChE and BChE react with the opposite enantiomers and that an induced-fit rearrangement of Phe297 enlarges the active site of AChE upon CBDP binding. 2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide 190-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 23339663-8 2013 X-ray crystallography and mass spectrometry show the formation of an aged end product formed in both AChE and BChE that cannot be reactivated by current oxime-based therapeutics. Oximes 153-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 23339663-9 2013 Our study thus shows that only prophylactic and symptomatic treatments are viable to counter the inhibition of AChE and BChE by CBDP. 2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide 128-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 23429378-2 2013 The compounds were prepared based on the multi-target-directed ligand strategy with different linker lengths (n = 2-8) joining the well-known NMDA antagonist adamantine and the hAChE inhibitor 7-methoxytacrine (7-MEOTA). 7-methoxytacrine 193-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-182 23429378-5 2013 The most potent cholinesterase inhibitor was found to be thiourea analogue 14 (with an IC50 value of 0.47 microM for hAChE and an IC50 value of 0.11 microM for hBChE, respectively). Thiourea 57-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-122 23215841-3 2013 AREAS COVERED: This article briefly reviews about donepezil, a highly selective (IC(50) = 6.7 nM) centrally acting reversible acetylcholinesterase inhibitor that has been approved by FDA for treating cognitive deficit states such as in Alzheimer"s disease and its uses in clinical trials for the treatment of schizophrenia. Donepezil 50-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-146 22990135-0 2013 Quantitative structure-activity relationships for organophosphates binding to acetylcholinesterase. Organophosphates 50-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-98 22990135-1 2013 Organophosphates are a group of pesticides and chemical warfare nerve agents that inhibit acetylcholinesterase, the enzyme responsible for hydrolysis of the excitatory neurotransmitter acetylcholine. Organophosphates 0-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 22990135-4 2013 To address this concern, a quantitative structure-activity relationship (QSAR) was developed to predict pentavalent organophosphate oxon human acetylcholinesterase bimolecular rate constants. organophosphate oxon 116-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 22990135-16 2013 The results suggest that this QSAR model can be used in physiologically based pharmacokinetic/pharmacodynamic models of organophosphate toxicity to determine the rate of acetylcholinesterase inhibition. Organophosphates 120-135 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-190 23261030-2 2013 Two quaternary beta-carboline alkaloids, prunifoleine and 14-oxoprunifoleine, inhibited AChE, BChE and MAO-A with IC(50) values corresponding to 10 and 3.39 muM for AChE, 100 and 11 muM for BChE, and 7.41 and 6.92 muM for MAO-A, respectively. beta-carboline alkaloids 15-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 23261030-2 2013 Two quaternary beta-carboline alkaloids, prunifoleine and 14-oxoprunifoleine, inhibited AChE, BChE and MAO-A with IC(50) values corresponding to 10 and 3.39 muM for AChE, 100 and 11 muM for BChE, and 7.41 and 6.92 muM for MAO-A, respectively. beta-carboline alkaloids 15-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 23261030-2 2013 Two quaternary beta-carboline alkaloids, prunifoleine and 14-oxoprunifoleine, inhibited AChE, BChE and MAO-A with IC(50) values corresponding to 10 and 3.39 muM for AChE, 100 and 11 muM for BChE, and 7.41 and 6.92 muM for MAO-A, respectively. Prunifoleine 41-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 23261030-2 2013 Two quaternary beta-carboline alkaloids, prunifoleine and 14-oxoprunifoleine, inhibited AChE, BChE and MAO-A with IC(50) values corresponding to 10 and 3.39 muM for AChE, 100 and 11 muM for BChE, and 7.41 and 6.92 muM for MAO-A, respectively. Prunifoleine 41-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 23261030-2 2013 Two quaternary beta-carboline alkaloids, prunifoleine and 14-oxoprunifoleine, inhibited AChE, BChE and MAO-A with IC(50) values corresponding to 10 and 3.39 muM for AChE, 100 and 11 muM for BChE, and 7.41 and 6.92 muM for MAO-A, respectively. 14-oxoprunifoleine 58-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 23261030-2 2013 Two quaternary beta-carboline alkaloids, prunifoleine and 14-oxoprunifoleine, inhibited AChE, BChE and MAO-A with IC(50) values corresponding to 10 and 3.39 muM for AChE, 100 and 11 muM for BChE, and 7.41 and 6.92 muM for MAO-A, respectively. 14-oxoprunifoleine 58-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 23261030-7 2013 Taken together, our findings established molecular details of AChE, BChE and MAO-A inhibition by quaternary beta-carboline alkaloids and MIAs from Psychotria, suggesting these secondary metabolites are scaffolds for the development of multifunctional compounds against neurodegeneration. beta-carboline alkaloids 108-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 23672025-3 2013 Compound 8n exhibited the strongest inhibition on acetylcholinesterase (AChE) with an IC50 value of 8.78 micromol x L(-1), and compound 8i showed the most potent inhibition on butyrylcholinesterase (BChE) with IC50 value of 1.60 micromol x L(-1) which was slightly better than rivastigmine. Rivastigmine 277-289 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 23312317-2 2013 The amperometric biosensor, fabricated by immobilizing AChE on multi-walled carbon nanotubes-chitosan (MWCNTs-Chi) nanocomposites modified glassy carbon electrode, enjoyed high sensitivity owing to the excellent conductivity and favourable biocompatibility of MWCNTs-Chi nanocomposites. Carbon 76-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 23312317-2 2013 The amperometric biosensor, fabricated by immobilizing AChE on multi-walled carbon nanotubes-chitosan (MWCNTs-Chi) nanocomposites modified glassy carbon electrode, enjoyed high sensitivity owing to the excellent conductivity and favourable biocompatibility of MWCNTs-Chi nanocomposites. Carbon 146-152 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-59 23312317-4 2013 Under optimum conditions, methyl parathion was detected based on its inhibition effect on AChE activity and the subsequent change in electrochemical reduction response of DTNB. Methyl Parathion 26-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 22391555-2 2013 The AChE-ICERs were prepared by using the homobifunctional linker glutaraldehyde through Schiff base linkage. Glutaral 66-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 22391555-2 2013 The AChE-ICERs were prepared by using the homobifunctional linker glutaraldehyde through Schiff base linkage. Schiff Bases 89-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 22391555-7 2013 The use of AChE-ICER in the ligands recognition assay was validated by evaluation of four known reversible inhibitors (galanthamine, tacrine, propidium, and rivastigmine), and the same order of inhibitory potencies described in the literature was found. Galantamine 119-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-15 22391555-7 2013 The use of AChE-ICER in the ligands recognition assay was validated by evaluation of four known reversible inhibitors (galanthamine, tacrine, propidium, and rivastigmine), and the same order of inhibitory potencies described in the literature was found. Tacrine 133-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-15 22391555-7 2013 The use of AChE-ICER in the ligands recognition assay was validated by evaluation of four known reversible inhibitors (galanthamine, tacrine, propidium, and rivastigmine), and the same order of inhibitory potencies described in the literature was found. Propidium 142-151 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-15 22391555-7 2013 The use of AChE-ICER in the ligands recognition assay was validated by evaluation of four known reversible inhibitors (galanthamine, tacrine, propidium, and rivastigmine), and the same order of inhibitory potencies described in the literature was found. Rivastigmine 157-169 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-15 22868055-0 2013 Biosensor based on acetylcholinesterase immobilized onto layered double hydroxides for flow injection/amperometric detection of organophosphate pesticides. Organophosphates 128-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 22868055-1 2013 We developed a highly sensitive flow injection/amperometric biosensor for the detection of organophosphate pesticides (OPs) using layered double hydroxides (LDHs) as the immobilization matrix of acetylcholinesterase (AChE). Organophosphates 91-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-215 22868055-1 2013 We developed a highly sensitive flow injection/amperometric biosensor for the detection of organophosphate pesticides (OPs) using layered double hydroxides (LDHs) as the immobilization matrix of acetylcholinesterase (AChE). Organophosphates 91-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 217-221 22868055-1 2013 We developed a highly sensitive flow injection/amperometric biosensor for the detection of organophosphate pesticides (OPs) using layered double hydroxides (LDHs) as the immobilization matrix of acetylcholinesterase (AChE). OPS 119-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-215 22868055-1 2013 We developed a highly sensitive flow injection/amperometric biosensor for the detection of organophosphate pesticides (OPs) using layered double hydroxides (LDHs) as the immobilization matrix of acetylcholinesterase (AChE). OPS 119-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 217-221 22868055-1 2013 We developed a highly sensitive flow injection/amperometric biosensor for the detection of organophosphate pesticides (OPs) using layered double hydroxides (LDHs) as the immobilization matrix of acetylcholinesterase (AChE). layered double hydroxides 130-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-215 22868055-1 2013 We developed a highly sensitive flow injection/amperometric biosensor for the detection of organophosphate pesticides (OPs) using layered double hydroxides (LDHs) as the immobilization matrix of acetylcholinesterase (AChE). layered double hydroxides 130-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 217-221 22868055-3 2013 By integrating the flow injection analysis (FIA) with amperometric detection, the resulting AChE-LDHs modified electrode greatly catalyzed the oxidation of the enzymatically generated thiocholine product, and facilitated the detection automation, thus increasing the detection sensitivity. Thiocholine 184-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 23344203-0 2013 Investigating the antioxidant and acetylcholinesterase inhibition activities of Gossypium herbaceam. gossypium herbaceam 80-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-54 23153113-4 2013 The enzymes AChE and CHO catalyze the formation of H(2)O(2) in the presence of acetylcholine, which then activates MNPs to catalyze the oxidation of colorimetric substrates to produce a color reaction. Hydrogen Peroxide 51-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-16 23153113-4 2013 The enzymes AChE and CHO catalyze the formation of H(2)O(2) in the presence of acetylcholine, which then activates MNPs to catalyze the oxidation of colorimetric substrates to produce a color reaction. Acetylcholine 79-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-16 23153113-5 2013 After incubation with the organophosphorus neurotoxins, the enzymatic activity of AChE was inhibited and produced less H(2)O(2), resulting in a decreased catalytic oxidation of colorimetric substrates over MNP peroxidase mimetics, accompanied by a drop in color intensity. Hydrogen Peroxide 119-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 24383001-0 2013 Acetylcholinesterase biosensors for electrochemical detection of organophosphorus compounds: a review. organophosphorus 65-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 22814970-9 2013 Combined use of atomic-force microscopy and CLSM revealed that AChE was homogeneously and selectively distributed on the SiO(2) microstructures at a suitable distance from the reflective surface. Silicon Dioxide 121-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 22814970-10 2013 In the optimum design, efficient fluorescence emission was obtained from the AChE-based biosensing surface after labelling with propidium, a selective fluorescent probe of the peripheral binding site of AChE. Propidium 128-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 22814970-10 2013 In the optimum design, efficient fluorescence emission was obtained from the AChE-based biosensing surface after labelling with propidium, a selective fluorescent probe of the peripheral binding site of AChE. Propidium 128-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 203-207 27390758-10 2013 This protocol measures the total choline in the cell supernatent under two conditions: 1) After treatment with acetylcholinesterase (AChE), which converts the ACh to choline (also called the total choline sample) and 2) after measuring the amount of free choline in the sample. Choline 33-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 27390758-10 2013 This protocol measures the total choline in the cell supernatent under two conditions: 1) After treatment with acetylcholinesterase (AChE), which converts the ACh to choline (also called the total choline sample) and 2) after measuring the amount of free choline in the sample. Acetylcholine 133-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 27390758-10 2013 This protocol measures the total choline in the cell supernatent under two conditions: 1) After treatment with acetylcholinesterase (AChE), which converts the ACh to choline (also called the total choline sample) and 2) after measuring the amount of free choline in the sample. Choline 117-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 27390758-10 2013 This protocol measures the total choline in the cell supernatent under two conditions: 1) After treatment with acetylcholinesterase (AChE), which converts the ACh to choline (also called the total choline sample) and 2) after measuring the amount of free choline in the sample. Choline 117-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 27390758-10 2013 This protocol measures the total choline in the cell supernatent under two conditions: 1) After treatment with acetylcholinesterase (AChE), which converts the ACh to choline (also called the total choline sample) and 2) after measuring the amount of free choline in the sample. Choline 117-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 24383001-3 2013 These pesticides contain organophosphorus (OP) toxic compounds which interfere with the proper functioning of enzyme acetylcholinesterase (AChE) and finally affect the central nervous system (CNS). organophosphorus 25-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 24383001-3 2013 These pesticides contain organophosphorus (OP) toxic compounds which interfere with the proper functioning of enzyme acetylcholinesterase (AChE) and finally affect the central nervous system (CNS). organophosphorus 25-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 23199476-0 2013 Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase. coumarin alkylamines 47-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 23936791-3 2013 As a specific molecular target of organophosphate and carbamate pesticides, acetylcholinesterase activity and its inhibition has been early recognized to be a human biological marker of pesticide poisoning. Organophosphates 34-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 23936791-3 2013 As a specific molecular target of organophosphate and carbamate pesticides, acetylcholinesterase activity and its inhibition has been early recognized to be a human biological marker of pesticide poisoning. Carbamates 54-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 23936791-4 2013 Measurement of AChE inhibition has been increasingly used in the last two decades as a biomarker of effect on nervous system following exposure to organophosphate and carbamate pesticides in occupational and environmental medicine. Organophosphates 147-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 23936791-4 2013 Measurement of AChE inhibition has been increasingly used in the last two decades as a biomarker of effect on nervous system following exposure to organophosphate and carbamate pesticides in occupational and environmental medicine. Carbamates 167-176 acetylcholinesterase (Cartwright blood group) Homo sapiens 15-19 23199476-4 2013 6,7-Dimethoxycoumarin derivatives carrying a protonatable benzylamino group, linked to position 3 by suitable linkers, exhibited fairly good AChE inhibitory activity and a high selectivity over BChE. benzylamino 58-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 23476830-1 2013 Neostigmine is a parasympathomimetic drug that acts as a reversible acetylcholinesterase inhibitor. Neostigmine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-88 23931437-2 2013 One possible approach for the treatment of this disease is the restoration of the level of acetylcholine (ACh) through the inhibition of acetylcholinesterase (AChE) with reversible inhibitors. Acetylcholine 91-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 23931437-2 2013 One possible approach for the treatment of this disease is the restoration of the level of acetylcholine (ACh) through the inhibition of acetylcholinesterase (AChE) with reversible inhibitors. Acetylcholine 91-104 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 23931437-2 2013 One possible approach for the treatment of this disease is the restoration of the level of acetylcholine (ACh) through the inhibition of acetylcholinesterase (AChE) with reversible inhibitors. Acetylcholine 106-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 23931437-2 2013 One possible approach for the treatment of this disease is the restoration of the level of acetylcholine (ACh) through the inhibition of acetylcholinesterase (AChE) with reversible inhibitors. Acetylcholine 106-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 23931437-3 2013 Naturally occurring alkaloids are an important source of AChE inhibitors. Alkaloids 20-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 23931437-7 2013 2) Coumarins, flavonoids, stilbenes, and other natural products are also important AChE inhibitors from natural products. Coumarins 3-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 23931437-7 2013 2) Coumarins, flavonoids, stilbenes, and other natural products are also important AChE inhibitors from natural products. Flavonoids 14-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 23931437-7 2013 2) Coumarins, flavonoids, stilbenes, and other natural products are also important AChE inhibitors from natural products. Stilbenes 26-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 23931443-1 2013 Tacrine (1) was the first acetylcholinesterase inhibitor (AChEI) introduced in therapy for the treatment of Alzheimer"s disease (AD), but similarly to the most recent approved AChEIs and memantine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, it does not represent an effective drug in halting the progression of AD. Tacrine 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 23461011-3 2013 Acetylcholinesterase reactivation peak (5-mins long) was found to take place upon introduction of dipyroxime (32.5%), pralidoxime (18%), carboxyme (16%) at a concentration of 2.5 x 10(-4) mol/l or toxogonine (26%) at a concentration of 5 x 10(-4) mol/l. Trimedoxime 98-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 23461011-3 2013 Acetylcholinesterase reactivation peak (5-mins long) was found to take place upon introduction of dipyroxime (32.5%), pralidoxime (18%), carboxyme (16%) at a concentration of 2.5 x 10(-4) mol/l or toxogonine (26%) at a concentration of 5 x 10(-4) mol/l. pralidoxime 118-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 23461011-3 2013 Acetylcholinesterase reactivation peak (5-mins long) was found to take place upon introduction of dipyroxime (32.5%), pralidoxime (18%), carboxyme (16%) at a concentration of 2.5 x 10(-4) mol/l or toxogonine (26%) at a concentration of 5 x 10(-4) mol/l. OBIDOXIME CHLORIDE 197-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24148993-1 2013 Acetylcholinesterase is a member of the alpha/beta hydrolase protein super family, with a significant role in acetylcholine-mediated neurotransmission. Acetylcholine 110-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 24148993-3 2013 Natural anti-AChE includes carbamates, glycoalkaloids, anatoxins derived from green algae; synthetic anti-AChE includes highly poisonous organophosphates used as nerve gases and insecticides. Organophosphates 137-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 24148993-4 2013 Recently, the role of anti-AChE was reassessed from neurotoxins to neuron-protective in the diseases characterized by impaired acetylcholine-mediated neurotransmission like Alzheimer"s disease (AD). Acetylcholine 127-140 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 23273608-0 2013 Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors. Donepezil 58-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 23273608-0 2013 Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors. huperzine A 72-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-115 23273608-1 2013 Four series of novel heterodimers comprised of donepezil and huperzine A (HupA) fragments were designed, synthesized, and evaluated in search of potent acetylcholinesterase (AChE) inhibitors as potential therapeutic treatment for Alzheimer"s disease. huperzine A 74-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 23273608-1 2013 Four series of novel heterodimers comprised of donepezil and huperzine A (HupA) fragments were designed, synthesized, and evaluated in search of potent acetylcholinesterase (AChE) inhibitors as potential therapeutic treatment for Alzheimer"s disease. huperzine A 74-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 23273608-2 2013 Heterodimers comprised of dimethoxyindanone (from donepezil), hupyridone (from HupA), and connected with a multimethylene linker, were identified as potent and selective inhibitors of AChE. dimethoxyindanone 26-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-188 23273608-2 2013 Heterodimers comprised of dimethoxyindanone (from donepezil), hupyridone (from HupA), and connected with a multimethylene linker, were identified as potent and selective inhibitors of AChE. Donepezil 50-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-188 23273608-2 2013 Heterodimers comprised of dimethoxyindanone (from donepezil), hupyridone (from HupA), and connected with a multimethylene linker, were identified as potent and selective inhibitors of AChE. 5-amino-5,6,7,8-tetrahydroquinolin-2(1H)-one 62-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-188 23273608-2 2013 Heterodimers comprised of dimethoxyindanone (from donepezil), hupyridone (from HupA), and connected with a multimethylene linker, were identified as potent and selective inhibitors of AChE. huperzine A 79-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-188 23273608-2 2013 Heterodimers comprised of dimethoxyindanone (from donepezil), hupyridone (from HupA), and connected with a multimethylene linker, were identified as potent and selective inhibitors of AChE. multimethylene 107-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 184-188 23410161-6 2013 The design strategy for yet another agent, ladostigil, employed the amalgamation of active chemical moieties of the AChE inhibitor rivastigmine, and the monoamine oxidase-B (MAO-B) inhibitor rasagiline, leading to a single compound that targets both enzymes simultaneously. (N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate 43-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 23550232-1 2013 Acrylonitrile(AN) is a neurotoxin both in animals and humans, but its effects on acetylcholinesterase (AChE) activity remain controversial. Acrylonitrile 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 23550232-1 2013 Acrylonitrile(AN) is a neurotoxin both in animals and humans, but its effects on acetylcholinesterase (AChE) activity remain controversial. Acrylonitrile 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 23550232-1 2013 Acrylonitrile(AN) is a neurotoxin both in animals and humans, but its effects on acetylcholinesterase (AChE) activity remain controversial. Ethanol 14-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 23550232-1 2013 Acrylonitrile(AN) is a neurotoxin both in animals and humans, but its effects on acetylcholinesterase (AChE) activity remain controversial. Ethanol 14-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 23199476-2 2013 Donepezil is one of most used AChEIs in AD therapy, acting as a dual binding site, reversible inhibitor of AChE with high selectivity over butyrylcholinesterase (BChE). Donepezil 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 23199476-4 2013 6,7-Dimethoxycoumarin derivatives carrying a protonatable benzylamino group, linked to position 3 by suitable linkers, exhibited fairly good AChE inhibitory activity and a high selectivity over BChE. scoparone 0-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-145 22750421-9 2013 Neostigmine (10 mumol l(-1)), an acetylcholinesterase inhibitor, mimicked the effects of nicotine. Neostigmine 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 22750421-9 2013 Neostigmine (10 mumol l(-1)), an acetylcholinesterase inhibitor, mimicked the effects of nicotine. Nicotine 89-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-53 23930233-8 2013 RESULTS: AChE and BuChE play a role in cholinergic signaling; BuChE can hydrolyze acetylcholine and compensate for AChE when levels are depleted. Acetylcholine 82-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 24211638-0 2013 Novel coumarin-3-carboxamides bearing N-benzylpiperidine moiety as potent acetylcholinesterase inhibitors. coumarin-3-carboxamides 6-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 24211638-0 2013 Novel coumarin-3-carboxamides bearing N-benzylpiperidine moiety as potent acetylcholinesterase inhibitors. 1-benzylpiperidine 38-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 24211638-1 2013 Some novel coumarin-3-carboxamide derivatives linked to N-benzylpiperidine scaffold were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. 2-oxo-2H-chromene-3-carboxamide 11-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 24211638-1 2013 Some novel coumarin-3-carboxamide derivatives linked to N-benzylpiperidine scaffold were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. 2-oxo-2H-chromene-3-carboxamide 11-33 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 24211638-1 2013 Some novel coumarin-3-carboxamide derivatives linked to N-benzylpiperidine scaffold were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. 1-benzylpiperidine 56-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 24211638-1 2013 Some novel coumarin-3-carboxamide derivatives linked to N-benzylpiperidine scaffold were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. 1-benzylpiperidine 56-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 24211638-4 2013 Compound 10c was 46-fold more potent than standard drug donepezil against AChE. Donepezil 56-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 23176543-1 2013 INTRODUCTION: The more or less systematic studies on the specific activity of oximes as reactivators of acetylcholinesterase (AChE) inhibited by organophosphorus (OP) compounds provide a panoramic image of their pharmacological and toxicological profiles. Oximes 78-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 23176543-1 2013 INTRODUCTION: The more or less systematic studies on the specific activity of oximes as reactivators of acetylcholinesterase (AChE) inhibited by organophosphorus (OP) compounds provide a panoramic image of their pharmacological and toxicological profiles. Oximes 78-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 23176543-1 2013 INTRODUCTION: The more or less systematic studies on the specific activity of oximes as reactivators of acetylcholinesterase (AChE) inhibited by organophosphorus (OP) compounds provide a panoramic image of their pharmacological and toxicological profiles. organophosphorus 145-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-124 23176543-1 2013 INTRODUCTION: The more or less systematic studies on the specific activity of oximes as reactivators of acetylcholinesterase (AChE) inhibited by organophosphorus (OP) compounds provide a panoramic image of their pharmacological and toxicological profiles. organophosphorus 145-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 23176543-5 2013 The non-homogenous distribution of oximes versus OP in tissues was considered and correlated with the highly variable AChE reactivation at both peripheral and central levels. Oximes 35-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-122 23535398-3 2013 However, we observed long term deficit after acute subcutaneous exposure to Chlorpyrifos (CPF) even when AChE activity is restored. Chlorpyrifos 76-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 23431890-6 2013 Some anticholinesterase, like donepezil, exhibits high specificity for centrally active acetylcholinesterase and raise ACh levels in the brain. Donepezil 30-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 23431890-9 2013 The drugs have slightly different pharmacological properties, but they all work by inhibiting the breakdown of acetylcholine, an important neurotransmitter associated with memory, by blocking the enzyme acetylcholinesterase. Acetylcholine 111-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 203-223 23386352-7 2013 This chapter describes both techniques using the deacetylation of acetyl-lysine residues in model peptides by sirtuin enzymes as well as the hydrolysis of acetylthiocholine by acetylcholinesterase as examples. Acetylthiocholine 155-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-196 24092978-1 2013 OBJECTIVE: While acetylcholinesterase inhibitors, such as donepezil, galantamine, and rivastig-mine, are beneficial in treating behavioral symptoms of patients with Alzheimer"s disease (AD), their dose-limiting effects include gastrointestinal disturbances, such as nausea, vomiting, and diarrhea. Donepezil 58-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 24092978-1 2013 OBJECTIVE: While acetylcholinesterase inhibitors, such as donepezil, galantamine, and rivastig-mine, are beneficial in treating behavioral symptoms of patients with Alzheimer"s disease (AD), their dose-limiting effects include gastrointestinal disturbances, such as nausea, vomiting, and diarrhea. Galantamine 69-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 17-37 24159418-6 2013 In the present work, the effects of three AChE inhibitors (donepezil, rivastigmine, and galantamine) were tested on H2O2-induced apoptosis in human umbilical vein endothelial cells (HUVECs) and on angiogenesis in chicken chorioallantoic membrane model. Hydrogen Peroxide 116-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-46 24288651-0 2013 Virtual screening and biological evaluation of piperazine derivatives as human acetylcholinesterase inhibitors. Piperazine 47-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-99 24288651-1 2013 The piperazine derivatives have been shown to inhibit human acetylcholinesterase. Piperazine 4-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 23149814-14 2013 Diazinon is very highly to moderately toxic aquatic arganisms, Diazinon inhibits the enzyme acetylcholinesterase, which hydrolyzes the neurotransmitter acetylcholine and leads to a suite of intermediate syndromes including anorexia, diarrhea, generalized weakness, muscle tremors, abnormal posturing and behavior, depression, and health. Diazinon 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 23515568-1 2013 Atomic force microscopy (AFM) was applied for obtaining structural information about acetylcholinesterase (AChE) tetramer (AChE G(4)) before and after reaction with S-acetylcholine iodide (S-ACh), in the presence or absence of propidium iodide (PI), an inhibitor for peripheral anionic sites (PAS). Acetylcholine 165-187 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 23515568-1 2013 Atomic force microscopy (AFM) was applied for obtaining structural information about acetylcholinesterase (AChE) tetramer (AChE G(4)) before and after reaction with S-acetylcholine iodide (S-ACh), in the presence or absence of propidium iodide (PI), an inhibitor for peripheral anionic sites (PAS). Acetylcholine 189-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 23515568-1 2013 Atomic force microscopy (AFM) was applied for obtaining structural information about acetylcholinesterase (AChE) tetramer (AChE G(4)) before and after reaction with S-acetylcholine iodide (S-ACh), in the presence or absence of propidium iodide (PI), an inhibitor for peripheral anionic sites (PAS). Acetylcholine 189-194 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 23515568-1 2013 Atomic force microscopy (AFM) was applied for obtaining structural information about acetylcholinesterase (AChE) tetramer (AChE G(4)) before and after reaction with S-acetylcholine iodide (S-ACh), in the presence or absence of propidium iodide (PI), an inhibitor for peripheral anionic sites (PAS). Propidium 227-243 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 23515568-1 2013 Atomic force microscopy (AFM) was applied for obtaining structural information about acetylcholinesterase (AChE) tetramer (AChE G(4)) before and after reaction with S-acetylcholine iodide (S-ACh), in the presence or absence of propidium iodide (PI), an inhibitor for peripheral anionic sites (PAS). Propidium 227-243 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 23515568-1 2013 Atomic force microscopy (AFM) was applied for obtaining structural information about acetylcholinesterase (AChE) tetramer (AChE G(4)) before and after reaction with S-acetylcholine iodide (S-ACh), in the presence or absence of propidium iodide (PI), an inhibitor for peripheral anionic sites (PAS). Aminosalicylic Acid 293-296 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 23515568-1 2013 Atomic force microscopy (AFM) was applied for obtaining structural information about acetylcholinesterase (AChE) tetramer (AChE G(4)) before and after reaction with S-acetylcholine iodide (S-ACh), in the presence or absence of propidium iodide (PI), an inhibitor for peripheral anionic sites (PAS). Aminosalicylic Acid 293-296 acetylcholinesterase (Cartwright blood group) Homo sapiens 107-111 23515568-3 2013 Ves-fusion technique was applied for incorporating AChE G(4) in a lipid layer on mica. mica 81-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 23515568-7 2013 After reaction with S-ACh in the absence of PI, the loose arrangement of subunits of AChE G(4) was seen, with an average size of 104 +- 7 nm in length, 91 +- 5 nm in width, and 8 +- 2 nm in height. Acetylcholine 20-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 22990946-2 2013 Like other carbamates, it inhibits AChE activity, resulting in nerve and/or tissue failure and possibly death. Carbamates 11-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 23149814-14 2013 Diazinon is very highly to moderately toxic aquatic arganisms, Diazinon inhibits the enzyme acetylcholinesterase, which hydrolyzes the neurotransmitter acetylcholine and leads to a suite of intermediate syndromes including anorexia, diarrhea, generalized weakness, muscle tremors, abnormal posturing and behavior, depression, and health. Diazinon 63-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 23863115-2 2013 The MD simulation was performed on AChE to obtain enzyme conformation in a water environment. Water 75-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 23323211-5 2013 These results further support our hypothesis that the insect-specific AChE cysteine is a unique and unexplored target to develop new insecticides with reduced insecticide resistance and low toxicity to mammals, fish, and birds for the control of mosquito-borne diseases. Cysteine 75-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 23186408-0 2012 Energy landscapes of human acetylcholinesterase and its Huperzine A-inhibited counterpart. huperzine A 56-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 24291871-7 2013 Rivastigmine increase acetylcholine in the cholinergic synapse by inhibition of both AChE and butyrylcholinesterase. Rivastigmine 0-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 24291871-7 2013 Rivastigmine increase acetylcholine in the cholinergic synapse by inhibition of both AChE and butyrylcholinesterase. Acetylcholine 22-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 23273207-8 2012 The extracts derived from Argemone mexicana and Datura metal exhibited strong AChE inhibitory potential, whereas others did not show significant inhibition even at higher concentrations. datura metal 48-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 78-82 23186408-8 2012 We report here on investigations of the enzyme human acetylcholinesterase, unliganded and in complex with the noncovalent inhibitor Huperzine A, by incoherent neutron scattering. huperzine A 132-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 23148598-1 2012 Pyridinium and bis-pyridinium aldoximes are used as antidotes to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus nerve agents. bis-pyridinium 15-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 23140986-0 2012 Novel coumarin derivatives bearing N-benzyl pyridinium moiety: potent and dual binding site acetylcholinesterase inhibitors. coumarin 6-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 23140986-0 2012 Novel coumarin derivatives bearing N-benzyl pyridinium moiety: potent and dual binding site acetylcholinesterase inhibitors. n-benzyl pyridinium 35-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-112 23140986-1 2012 A novel series of coumarin derivatives linked to benzyl pyridinium group were synthesized and biologically evaluated as inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). coumarin 18-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-159 23140986-1 2012 A novel series of coumarin derivatives linked to benzyl pyridinium group were synthesized and biologically evaluated as inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). coumarin 18-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-165 23140986-1 2012 A novel series of coumarin derivatives linked to benzyl pyridinium group were synthesized and biologically evaluated as inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). benzyl pyridinium 49-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-159 23140986-1 2012 A novel series of coumarin derivatives linked to benzyl pyridinium group were synthesized and biologically evaluated as inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). benzyl pyridinium 49-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-165 23148598-0 2012 Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase. phenyltetrahydroisoquinoline-pyridinaldoxime 0-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-155 23148598-1 2012 Pyridinium and bis-pyridinium aldoximes are used as antidotes to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus nerve agents. pyridine 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 23148598-1 2012 Pyridinium and bis-pyridinium aldoximes are used as antidotes to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus nerve agents. pyridine 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 23148598-1 2012 Pyridinium and bis-pyridinium aldoximes are used as antidotes to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus nerve agents. bis-pyridinium 15-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 22703537-2 2012 It acts via phosphorylation of a serine residue in the active site of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), leading to enzyme inactivation. Serine 33-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-90 22703537-2 2012 It acts via phosphorylation of a serine residue in the active site of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), leading to enzyme inactivation. Serine 33-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 22703537-5 2012 In addition, we performed molecular docking studies in non-aged methamidophos-inhibited AChE to understand the mechanisms involved. methamidophos 64-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-92 22703537-11 2012 In conclusion, our work demonstrated that the newly synthesised oximes were able to reactivate not only human erythrocyte AChE but also human plasma BChE, which could represent an advantage in the treatment of OP compounds poisoning. Oximes 64-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 23108363-6 2012 In particular, benzotriazinone 24 and triazafluoranthenone 38 were endowed with an interesting multiple activity, the former displaying IC(50) values of 1.4, 1.5 and 1.9 muM on Abeta aggregation and AChE and BChE inhibition, respectively, and the latter showing IC(50) values of 1.4 and an outstanding 0.025 muM in the Abeta aggregation and BChE inhibition, respectively. 1,2,3-benzotriazin-4-one 15-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-203 23108363-6 2012 In particular, benzotriazinone 24 and triazafluoranthenone 38 were endowed with an interesting multiple activity, the former displaying IC(50) values of 1.4, 1.5 and 1.9 muM on Abeta aggregation and AChE and BChE inhibition, respectively, and the latter showing IC(50) values of 1.4 and an outstanding 0.025 muM in the Abeta aggregation and BChE inhibition, respectively. triazafluoranthenone 38-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-203 23169765-0 2012 Carbamate protection of AChE against inhibition by agricultural chemicals. Carbamates 0-9 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 22841891-5 2012 Furthermore, staurosporine treatment resulted in decreased acetylcholinesterase (AChE) enzymatic activity and decreased protein levels of the AChE splice variant tailed AChE (AChE-T). Staurosporine 13-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 22841891-5 2012 Furthermore, staurosporine treatment resulted in decreased acetylcholinesterase (AChE) enzymatic activity and decreased protein levels of the AChE splice variant tailed AChE (AChE-T). Staurosporine 13-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 22841891-5 2012 Furthermore, staurosporine treatment resulted in decreased acetylcholinesterase (AChE) enzymatic activity and decreased protein levels of the AChE splice variant tailed AChE (AChE-T). Staurosporine 13-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 22841891-5 2012 Furthermore, staurosporine treatment resulted in decreased acetylcholinesterase (AChE) enzymatic activity and decreased protein levels of the AChE splice variant tailed AChE (AChE-T). Staurosporine 13-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 22841891-5 2012 Furthermore, staurosporine treatment resulted in decreased acetylcholinesterase (AChE) enzymatic activity and decreased protein levels of the AChE splice variant tailed AChE (AChE-T). Staurosporine 13-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 22841891-9 2012 The effects of various additional phosphorylation inhibitors on AChE activity suggest that these unexpected cholinergic effects, firstly, are linked to the impact of staurosporine on phosphorylation and, secondly, reveal themselves in a first phase of cellular adaption that precedes neurotoxicity and subsequent cell death. Staurosporine 166-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 64-68 23279148-3 2012 Administration of donepezil, an acetylcholinesterase inhibitor, markedly improved delusional symptoms and cognitive function. Donepezil 18-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 23033965-2 2012 The compounds were designed by taking advantage of the crystal structures of acetylcholinesterase (AChE) in complex with galantamine derivatives. Galantamine 121-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 23033965-2 2012 The compounds were designed by taking advantage of the crystal structures of acetylcholinesterase (AChE) in complex with galantamine derivatives. Galantamine 121-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 23062825-6 2012 Analysis of the kinetic mechanism of the AChE inhibition revealed chelerythrine as a mixed inhibitor. chelerythrine 66-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 23062825-7 2012 Using molecular docking studies, it was further proven that chelerythrine binds on both the catalytic site and the peripheral anionic site (PAS) of the AChE. chelerythrine 60-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 23062825-7 2012 Using molecular docking studies, it was further proven that chelerythrine binds on both the catalytic site and the peripheral anionic site (PAS) of the AChE. Aminosalicylic Acid 140-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-156 23062825-10 2012 This approach enabled for the first time to identify a cholinesterase inhibitor of natural origin-chelerythrine-acting on AChE and BChE with a dual ability to inhibit Abeta aggregation as well as to disaggregate preformed Abeta aggregates. chelerythrine 98-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 23148598-1 2012 Pyridinium and bis-pyridinium aldoximes are used as antidotes to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus nerve agents. organophosphorus 117-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 23148598-1 2012 Pyridinium and bis-pyridinium aldoximes are used as antidotes to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus nerve agents. organophosphorus 117-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 23148598-2 2012 Herein, we described a series of nine nonquaternary phenyltetrahydroisoquinoline-pyridinaldoxime conjugates more efficient than or as efficient as pyridinium oximes to reactivate VX-, tabun- and ethyl paraoxon-inhibited human AChE. phenyltetrahydroisoquinoline-pyridinaldoxime 52-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-230 23148598-2 2012 Herein, we described a series of nine nonquaternary phenyltetrahydroisoquinoline-pyridinaldoxime conjugates more efficient than or as efficient as pyridinium oximes to reactivate VX-, tabun- and ethyl paraoxon-inhibited human AChE. pyridinium oximes 147-164 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-230 23035744-2 2012 Here we present high resolution crystal structures of human AChE, alone and in complexes with drug ligands; donepezil, an Alzheimer"s disease drug, binds differently to human AChE than it does to Torpedo AChE. Donepezil 108-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 23148598-2 2012 Herein, we described a series of nine nonquaternary phenyltetrahydroisoquinoline-pyridinaldoxime conjugates more efficient than or as efficient as pyridinium oximes to reactivate VX-, tabun- and ethyl paraoxon-inhibited human AChE. tabun 184-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-230 23035744-2 2012 Here we present high resolution crystal structures of human AChE, alone and in complexes with drug ligands; donepezil, an Alzheimer"s disease drug, binds differently to human AChE than it does to Torpedo AChE. Donepezil 108-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 175-179 23148598-2 2012 Herein, we described a series of nine nonquaternary phenyltetrahydroisoquinoline-pyridinaldoxime conjugates more efficient than or as efficient as pyridinium oximes to reactivate VX-, tabun- and ethyl paraoxon-inhibited human AChE. ethylparaoxon 195-209 acetylcholinesterase (Cartwright blood group) Homo sapiens 226-230 23035744-2 2012 Here we present high resolution crystal structures of human AChE, alone and in complexes with drug ligands; donepezil, an Alzheimer"s disease drug, binds differently to human AChE than it does to Torpedo AChE. Donepezil 108-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 175-179 23151013-4 2012 For most of the indoline-3-propionic acid derivatives, introduction of N-methyl-N-ethyl or N-methyl-N-(4-methoxyphenyl) carbamate moieties at positions 4, 6, or 7 conferred both acetyl (AChE) and butyryl (BuChE) cholinesterase inhibitory activities at similar concentrations to those that showed antioxidant activity. 3-(2,3-dihydro-1H-indol-3-yl)propanoic Acid 16-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 23151013-4 2012 For most of the indoline-3-propionic acid derivatives, introduction of N-methyl-N-ethyl or N-methyl-N-(4-methoxyphenyl) carbamate moieties at positions 4, 6, or 7 conferred both acetyl (AChE) and butyryl (BuChE) cholinesterase inhibitory activities at similar concentrations to those that showed antioxidant activity. n-methyl-n-ethyl 71-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 23151013-4 2012 For most of the indoline-3-propionic acid derivatives, introduction of N-methyl-N-ethyl or N-methyl-N-(4-methoxyphenyl) carbamate moieties at positions 4, 6, or 7 conferred both acetyl (AChE) and butyryl (BuChE) cholinesterase inhibitory activities at similar concentrations to those that showed antioxidant activity. n-methyl-n-(4-methoxyphenyl) carbamate 91-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 23151013-5 2012 The most potent AChE inhibitors were 120 (3-(2-aminoethyl) indolin-4-yl ethyl(methyl)carbamate dihydrochloride) and 94 (3-(3-methoxy-3-oxopropyl)-4-(((4-methoxyphenyl)(methyl) carbamoyl)oxy)indolin-1-ium hydrochloride) with IC50s of 0.4 and 1.2 muM, respectively. 3-(2-aminoethyl) indolin-4-yl ethyl(methyl)carbamate dihydrochloride 42-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 22932810-6 2012 Under the optimum conditions, using Huperzine-A as model inhibitor, K (i) and IC (50) were 0.551 mumol L(-1) and 1.52 mumol L(-1), respectively, for immobilized AChE. huperzine A 36-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-165 22932810-8 2012 Compared with previous publications on screening for AChE inhibitors in natural products based on CE methods, the method developed in this work has the advantages of lower cost per analysis, less leakage, and better bioaffinity for the immobilized enzyme because of the unique properties of sodium alginate and chitosan. Alginates 291-306 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 22677656-9 2012 Our results demonstrate that these drugs are very potent AChE inhibitors, especially (+-)-huprine 6 with an inhibitory activity on recombinant human AChE (rhAChE) in the picomolar range. (+-)-huprine 6 85-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-61 22876849-12 2012 Further research is warranted to delineate the mode of action of acetylcholinesterase inhibitors with respect to normalising 25OHD2 levels. 25ohd2 125-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 22595038-0 2012 Cognitive effects of the acetylcholinesterase inhibitor, donepezil, in healthy, non-treatment seeking smokers: a pilot feasibility study. Donepezil 57-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 22595038-3 2012 Endogenous acetylcholine levels, which are modulated by acetylcholinesterase inhibitors (AChEIs), play an important role in smoking behavior and cognition. Acetylcholine 11-24 acetylcholinesterase (Cartwright blood group) Homo sapiens 56-76 23078965-0 2012 Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer"s disease: synthesis, biological assessment, and molecular modeling. pyridonepezils 0-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-29 23078965-7 2012 Molecular modeling investigation on pyridonepezil7 supports its dual AChE inhibitory profile, binding simultaneously at the catalytic active and at peripheral anionic sites of the enzyme. pyridonepezil7 36-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 22697296-7 2012 That fluoxetine induces vasodilatation of cerebral arterioles suggests co-promotion of endothelial muscarinic and nitric oxide signalling, facilitated by albumin-dependent inhibition of serum AChE. Fluoxetine 5-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 22677656-9 2012 Our results demonstrate that these drugs are very potent AChE inhibitors, especially (+-)-huprine 6 with an inhibitory activity on recombinant human AChE (rhAChE) in the picomolar range. (+-)-huprine 6 85-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 22996404-1 2012 The reversible inhibition of acetylcholinesterase (AChE) has become a promising target for the treatment of Alzheimer"s disease (AD) which is mainly associated with low in vivo levels of acetylcholine (ACh). Acetylcholine 29-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 22996404-1 2012 The reversible inhibition of acetylcholinesterase (AChE) has become a promising target for the treatment of Alzheimer"s disease (AD) which is mainly associated with low in vivo levels of acetylcholine (ACh). Acetylcholine 51-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 22984913-1 2012 Acetylcholinesterase (AChE) is a crucial enzyme in the cholinergic nervous system that hydrolyzes neurotransmitter acetylcholine (ACh) and terminates synaptic signals. Acetylcholine 115-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 23021811-0 2012 A rational design of the multiwalled carbon nanotube-7,7,8,8-tetracyanoquinodimethan sensor for sensitive detection of acetylcholinesterase inhibitors. Carbon 37-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 23021811-0 2012 A rational design of the multiwalled carbon nanotube-7,7,8,8-tetracyanoquinodimethan sensor for sensitive detection of acetylcholinesterase inhibitors. 7,7,8,8-tetracyanoquinodimethan 53-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-139 23021811-1 2012 A new, simple and effective amperometric acetylcholinesterase biosensor was developed using screen-printed carbon electrodes modified with carbon nanotubes (MWCNTs)-7,7,8,8-tetracyanoquinodimethane (TCNQ). Carbon 107-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 23021811-1 2012 A new, simple and effective amperometric acetylcholinesterase biosensor was developed using screen-printed carbon electrodes modified with carbon nanotubes (MWCNTs)-7,7,8,8-tetracyanoquinodimethane (TCNQ). Carbon 139-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 23021811-1 2012 A new, simple and effective amperometric acetylcholinesterase biosensor was developed using screen-printed carbon electrodes modified with carbon nanotubes (MWCNTs)-7,7,8,8-tetracyanoquinodimethane (TCNQ). tetracyanoquinodimethane 165-197 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 23021811-1 2012 A new, simple and effective amperometric acetylcholinesterase biosensor was developed using screen-printed carbon electrodes modified with carbon nanotubes (MWCNTs)-7,7,8,8-tetracyanoquinodimethane (TCNQ). tetracyanoquinodimethane 199-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-61 23021811-6 2012 The biosensor developed by immobilization of acetylcholinesterase (AChE) in sol-gel allowed the detection of two reference AChE inhibitors, paraoxon-methyl and chlorpyrifos with detection limits of 30 pM (7 ppt) and 0.4 nM (0.1 ppb), respectively. methylparaoxon 140-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 23021811-6 2012 The biosensor developed by immobilization of acetylcholinesterase (AChE) in sol-gel allowed the detection of two reference AChE inhibitors, paraoxon-methyl and chlorpyrifos with detection limits of 30 pM (7 ppt) and 0.4 nM (0.1 ppb), respectively. methylparaoxon 140-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 23021811-6 2012 The biosensor developed by immobilization of acetylcholinesterase (AChE) in sol-gel allowed the detection of two reference AChE inhibitors, paraoxon-methyl and chlorpyrifos with detection limits of 30 pM (7 ppt) and 0.4 nM (0.1 ppb), respectively. Chlorpyrifos 160-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 23021811-6 2012 The biosensor developed by immobilization of acetylcholinesterase (AChE) in sol-gel allowed the detection of two reference AChE inhibitors, paraoxon-methyl and chlorpyrifos with detection limits of 30 pM (7 ppt) and 0.4 nM (0.1 ppb), respectively. Chlorpyrifos 160-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 23021811-6 2012 The biosensor developed by immobilization of acetylcholinesterase (AChE) in sol-gel allowed the detection of two reference AChE inhibitors, paraoxon-methyl and chlorpyrifos with detection limits of 30 pM (7 ppt) and 0.4 nM (0.1 ppb), respectively. 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol 207-210 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-65 23021811-6 2012 The biosensor developed by immobilization of acetylcholinesterase (AChE) in sol-gel allowed the detection of two reference AChE inhibitors, paraoxon-methyl and chlorpyrifos with detection limits of 30 pM (7 ppt) and 0.4 nM (0.1 ppb), respectively. 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol 207-210 acetylcholinesterase (Cartwright blood group) Homo sapiens 67-71 23021811-6 2012 The biosensor developed by immobilization of acetylcholinesterase (AChE) in sol-gel allowed the detection of two reference AChE inhibitors, paraoxon-methyl and chlorpyrifos with detection limits of 30 pM (7 ppt) and 0.4 nM (0.1 ppb), respectively. 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol 207-210 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 22984913-1 2012 Acetylcholinesterase (AChE) is a crucial enzyme in the cholinergic nervous system that hydrolyzes neurotransmitter acetylcholine (ACh) and terminates synaptic signals. Acetylcholine 115-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 22984913-1 2012 Acetylcholinesterase (AChE) is a crucial enzyme in the cholinergic nervous system that hydrolyzes neurotransmitter acetylcholine (ACh) and terminates synaptic signals. Acetylcholine 22-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 22984913-2 2012 The catalytic serine of AChE can be phosphonylated by soman, one of the most potent nerve agents, and subsequently undergo an aging reaction. Serine 14-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 22984913-4 2012 By employing Born-Oppenheimer ab initio QM/MM molecular dynamics simulations with umbrella sampling, a state-of-the-art approach to simulate enzyme reactions, we have characterized the aging mechanism of soman phosphonylated AChE and determined its free energy profile. oppenheimer 18-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 225-229 22796536-3 2012 In the presence of organophosphorus compounds, the degree of inhibitory effect of organophosphorus compounds on the AChE activity and the concentration of pesticides were detected in real time by measuring the frequency shift of the resonator. organophosphorus 19-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 22796536-3 2012 In the presence of organophosphorus compounds, the degree of inhibitory effect of organophosphorus compounds on the AChE activity and the concentration of pesticides were detected in real time by measuring the frequency shift of the resonator. organophosphorus 82-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-120 23256657-5 2012 Such an appropriate system for the detection of carbamates and highly toxic organophosphates is detection tubes with microcrystalline cellulose pellets containing immobilized acetylcholinesterase, by which analyzed air is sucked through. Carbamates 48-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 175-195 23256657-5 2012 Such an appropriate system for the detection of carbamates and highly toxic organophosphates is detection tubes with microcrystalline cellulose pellets containing immobilized acetylcholinesterase, by which analyzed air is sucked through. Organophosphates 76-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 175-195 23372236-2 2012 Donepezil hydrochloride is a potent, reversible, and highly selective inhibitor of acetylcholinesterase (AChE). Donepezil 0-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 22972560-1 2012 A quantitative analysis of the interaction sites of the anti-Alzheimer drug galanthamine with molecular probes (water and benzene molecules) representative of its surroundings in the binding site of acetylcholinesterase (AChE) has been realized through pairwise potentials calculations and quantum chemistry. Water 112-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-219 22972560-1 2012 A quantitative analysis of the interaction sites of the anti-Alzheimer drug galanthamine with molecular probes (water and benzene molecules) representative of its surroundings in the binding site of acetylcholinesterase (AChE) has been realized through pairwise potentials calculations and quantum chemistry. Water 112-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 221-225 22972560-1 2012 A quantitative analysis of the interaction sites of the anti-Alzheimer drug galanthamine with molecular probes (water and benzene molecules) representative of its surroundings in the binding site of acetylcholinesterase (AChE) has been realized through pairwise potentials calculations and quantum chemistry. Benzene 122-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 199-219 22972560-1 2012 A quantitative analysis of the interaction sites of the anti-Alzheimer drug galanthamine with molecular probes (water and benzene molecules) representative of its surroundings in the binding site of acetylcholinesterase (AChE) has been realized through pairwise potentials calculations and quantum chemistry. Benzene 122-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 221-225 22972560-7 2012 The trends obtained provide rationales to the predilection of the equatorial orientation of the galanthamine N-methyl substituent for binding to AChE. galanthamine n 96-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149 22972560-9 2012 The comparison between the cluster calculations and the crystallographic observations in galanthamine-AChE co-crystals allows the validation of the theoretical methodology. Galantamine 89-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 22972560-10 2012 In particular, the positions of several water molecules appearing as strongly conserved in galanthamine-AChE co-crystals are predicted by the calculations. Water 40-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 22972560-10 2012 In particular, the positions of several water molecules appearing as strongly conserved in galanthamine-AChE co-crystals are predicted by the calculations. Galantamine 91-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 22972560-12 2012 Our study provides relevant information for a rational drug design of galanthamine based AChE inhibitors. Galantamine 70-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 24052808-0 2012 Synthesis and in silico evaluation of 1N-methyl-1S-methyl-2-nitroethylene (NMSM) derivatives against Alzheimer disease: to understand their interacting mechanism with acetylcholinesterase. 1n-methyl-1s-methyl-2-nitroethylene 38-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-187 23085657-0 2012 A novel class of selective acetylcholinesterase inhibitors: synthesis and evaluation of (E)-2-(benzo[d]thiazol-2-yl)-3-heteroarylacrylonitriles. (e)-2-(benzo[d]thiazol-2-yl)-3-heteroarylacrylonitriles 88-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-47 23085657-1 2012 (E)-2-(benzo[d]thiazol-2-yl)-3-heteroarylacrylonitriles are described as a new class of selective inhibitors of acetylcholinesterase (AChE). (e)-2-(benzo[d]thiazol-2-yl)-3-heteroarylacrylonitriles 0-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 23085657-1 2012 (E)-2-(benzo[d]thiazol-2-yl)-3-heteroarylacrylonitriles are described as a new class of selective inhibitors of acetylcholinesterase (AChE). (e)-2-(benzo[d]thiazol-2-yl)-3-heteroarylacrylonitriles 0-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 23085657-3 2012 Compound 7f was found to be more selective than galanthamine in inhibiting AChE and it showed a moderate selectivity index. Galantamine 48-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 23085657-4 2012 Kinetic studies on AChE indicated that a competitive type of inhibition pattern exist for these acrylonitrile derivates. Acrylonitrile 96-109 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 22842334-0 2012 Novel bis-(-)-nor-meptazinol derivatives act as dual binding site AChE inhibitors with metal-complexing property. bis-(-)-nor-meptazinol 6-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 22842334-0 2012 Novel bis-(-)-nor-meptazinol derivatives act as dual binding site AChE inhibitors with metal-complexing property. Metals 87-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 22842334-2 2012 In the present study, two derivatives (ZLA and ZLB) of a potent dual binding site AChE inhibitor bis-(-)-nor-meptazinol (bis-MEP) were designed and synthesized by introducing metal chelating pharmacophores into the middle chain of bis-MEP. 1-{2-[3,5-dicyclopropyl-4-(4-{[(quinoxaline-2-carbonyl)amino]methyl}-1H-1,2,3-triazol-1-yl)phenyl]acetamido}cyclohexane-1-carboxylic acid 39-42 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 22842334-2 2012 In the present study, two derivatives (ZLA and ZLB) of a potent dual binding site AChE inhibitor bis-(-)-nor-meptazinol (bis-MEP) were designed and synthesized by introducing metal chelating pharmacophores into the middle chain of bis-MEP. zlb 47-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 22842334-2 2012 In the present study, two derivatives (ZLA and ZLB) of a potent dual binding site AChE inhibitor bis-(-)-nor-meptazinol (bis-MEP) were designed and synthesized by introducing metal chelating pharmacophores into the middle chain of bis-MEP. bis-(-)-nor-meptazinol 97-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 22842334-2 2012 In the present study, two derivatives (ZLA and ZLB) of a potent dual binding site AChE inhibitor bis-(-)-nor-meptazinol (bis-MEP) were designed and synthesized by introducing metal chelating pharmacophores into the middle chain of bis-MEP. bis-MEP 121-128 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 22842334-2 2012 In the present study, two derivatives (ZLA and ZLB) of a potent dual binding site AChE inhibitor bis-(-)-nor-meptazinol (bis-MEP) were designed and synthesized by introducing metal chelating pharmacophores into the middle chain of bis-MEP. Metals 175-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 22842334-2 2012 In the present study, two derivatives (ZLA and ZLB) of a potent dual binding site AChE inhibitor bis-(-)-nor-meptazinol (bis-MEP) were designed and synthesized by introducing metal chelating pharmacophores into the middle chain of bis-MEP. bis-MEP 231-238 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 24052808-0 2012 Synthesis and in silico evaluation of 1N-methyl-1S-methyl-2-nitroethylene (NMSM) derivatives against Alzheimer disease: to understand their interacting mechanism with acetylcholinesterase. nmsm 75-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-187 24052808-1 2012 Anomalous action of human acetylcholinesterase (hAChE) in Alzheimer"s disease (AD) was restrained by various AChE inhibitors, of which the specific and potent lead candidate Donepezil is used for treating the disease AD. Donepezil 174-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 24052808-1 2012 Anomalous action of human acetylcholinesterase (hAChE) in Alzheimer"s disease (AD) was restrained by various AChE inhibitors, of which the specific and potent lead candidate Donepezil is used for treating the disease AD. Donepezil 174-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-53 24052808-1 2012 Anomalous action of human acetylcholinesterase (hAChE) in Alzheimer"s disease (AD) was restrained by various AChE inhibitors, of which the specific and potent lead candidate Donepezil is used for treating the disease AD. Donepezil 174-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-53 24052808-6 2012 The site-specific interactions formed between these molecules also results in a conformational change in the orientation of active site residues of hAChE, which prevents them from being accessed by beta-amyloid protein (Abeta), which is a causative agent for amyloid plaque formation and acetylcholine (ACh). Acetylcholine 288-301 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-153 22901043-1 2012 Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) catalyze the hydrolysis of the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission. Acetylcholine 110-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 22901043-1 2012 Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) catalyze the hydrolysis of the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission. Acetylcholine 110-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 22901043-7 2012 In human AChE, certain aryl residues in the vicinity of the anionic aspartate residue (D74), such as W286, have been implicated in ligand binding and have therefore been considered part of the P-site of the enzyme. Aspartic Acid 68-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 22901043-7 2012 In human AChE, certain aryl residues in the vicinity of the anionic aspartate residue (D74), such as W286, have been implicated in ligand binding and have therefore been considered part of the P-site of the enzyme. d74 87-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 22901043-7 2012 In human AChE, certain aryl residues in the vicinity of the anionic aspartate residue (D74), such as W286, have been implicated in ligand binding and have therefore been considered part of the P-site of the enzyme. w286 101-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 22946763-5 2012 The immobilized AChE on the 3DOM composite displayed favorable affinity to substrate acetylthiocholine chloride (ATCh), and the 3DOM composite showed excellent electrocatalytic effect on thiocholine, the hydrolysis product of ATCh. Acetylthiocholine chloride 85-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 22946763-5 2012 The immobilized AChE on the 3DOM composite displayed favorable affinity to substrate acetylthiocholine chloride (ATCh), and the 3DOM composite showed excellent electrocatalytic effect on thiocholine, the hydrolysis product of ATCh. atch 113-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 22946763-5 2012 The immobilized AChE on the 3DOM composite displayed favorable affinity to substrate acetylthiocholine chloride (ATCh), and the 3DOM composite showed excellent electrocatalytic effect on thiocholine, the hydrolysis product of ATCh. Thiocholine 91-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 22946763-7 2012 The designed AChE biosensor was successfully applied to evaluate the AChE inhibition induced by endogenous neurotoxin 1(R),2N-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline [(R)-NMSal]. salsoline 118-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 22946763-7 2012 The designed AChE biosensor was successfully applied to evaluate the AChE inhibition induced by endogenous neurotoxin 1(R),2N-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline [(R)-NMSal]. salsoline 118-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 22946763-7 2012 The designed AChE biosensor was successfully applied to evaluate the AChE inhibition induced by endogenous neurotoxin 1(R),2N-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline [(R)-NMSal]. (r)-nmsal 181-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 13-17 22946763-7 2012 The designed AChE biosensor was successfully applied to evaluate the AChE inhibition induced by endogenous neurotoxin 1(R),2N-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline [(R)-NMSal]. (r)-nmsal 181-190 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 22946763-8 2012 The results demonstrate that (R)-NMSal exerts a considerable effect on AChE activity, and the inhibition is reversible. (r)-nmsal 29-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 22958411-5 2012 The structure-activity relationships indicated that (i) the 1-O-(methylthio)methyl substituent in lycorine was better than the 1-O-acetyl group for the inhibition of cholinesterase; (ii) the acylated or etherified derivatives of lycorine and lycorin-2-one were more potent against hBChE than hAChE; and (iii) the oxidation of lycorine at C-2 decreases the activity. lycorine 98-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 292-297 22958411-6 2012 CONCLUSION: Acylated or etherified derivatives of lycorine are potential dual inhibitors of hBChE and hAChE. lycorine 50-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-107 22958411-5 2012 The structure-activity relationships indicated that (i) the 1-O-(methylthio)methyl substituent in lycorine was better than the 1-O-acetyl group for the inhibition of cholinesterase; (ii) the acylated or etherified derivatives of lycorine and lycorin-2-one were more potent against hBChE than hAChE; and (iii) the oxidation of lycorine at C-2 decreases the activity. 1-hexadecyl-2-acetyl-glycero-3-phosphocholine 60-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 292-297 22437842-0 2012 Reactivation kinetics of a homologous series of bispyridinium bis-oximes with nerve agent-inhibited human acetylcholinesterase. bispyridinium bis-oximes 48-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 22437842-1 2012 The reactivation of organophosphorus compound (OP)-inhibited acetylcholinesterase (AChE) by oximes is inadequate in case of different OP nerve agents. organophosphorus 20-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 22437842-1 2012 The reactivation of organophosphorus compound (OP)-inhibited acetylcholinesterase (AChE) by oximes is inadequate in case of different OP nerve agents. organophosphorus 20-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 22437842-1 2012 The reactivation of organophosphorus compound (OP)-inhibited acetylcholinesterase (AChE) by oximes is inadequate in case of different OP nerve agents. Oximes 92-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 22437842-1 2012 The reactivation of organophosphorus compound (OP)-inhibited acetylcholinesterase (AChE) by oximes is inadequate in case of different OP nerve agents. Oximes 92-98 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 22437842-3 2012 In the present study, we investigated the reactivation kinetics of a homologous series of bispyridinium bis-oximes bearing a (E)-but-2-ene linker with tabun-, sarin-, and cyclosarin-inhibited human AChE. bispyridinium bis-oximes 90-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-202 22437842-4 2012 In part, marked differences in affinity and reactivity of the investigated oximes toward OP-inhibited human AChE were recorded. Oximes 75-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-112 23054722-0 2012 A novel 7-O-modified genistein derivative with acetylcholinesterase inhibitory effect, estrogenic activity and neuroprotective effect. Genistein 21-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 23054722-2 2012 GS-14 acted as a selective AChE inhibitor in vitro, with an IC50 value of 0.17 muM and showed no inhibition activity against butyrylcholinesterase (BuChE). 7-(4-(diethylamino)butoxy)-5-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one 0-5 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 23054722-6 2012 Considering its AChE-inhibition activity, estrogenic activity and neuroprotective effect, GS-14 may be a potential multi-target agent for the treatment of AD. 7-(4-(diethylamino)butoxy)-5-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one 90-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 22941287-1 2012 Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer"s disease (AD). huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-142 22941287-1 2012 Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer"s disease (AD). huperzine A 0-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-148