PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33807122-5	2021	A western blot analysis demonstrated the use of trametinib alone and trametinib in combination with ribociclib to decrease the expression of pERK, cMyc, Chk1, pChk2, pCDK1, CyclinD1, and c-myc in a time-dependent manner in NCI-H727 and QGP-1 cells.	trametinib	48-58	cyclin D1	Homo sapiens	173-181
2181375-3	1990	Concerning band q13: (i) 50 tumors (approximately 17%) were co-amplified for BCL-1, HST & INT-2; (ii) in 3 cases, amplification extended to the SEA gene; (iii) in 6 carcinomas, BCL-1 was the only amplified marker.	Adenosine Monophosphate	63-66	cyclin D1	Homo sapiens	77-82
33818655-3	2021	In this study, we explored Cd-induced mechanisms downstream of MAPK and whether Cd could stimulate phosphorylation of Histone H3 at serine 10 (H3Ser10ph) through activated Aurora B kinase (pAurora B), a kinase important in activation of histone H3 at serine 10 during mitosis, and if this occurs via Fork head box M1 (FOXM1) and cyclin D1 immediately downstream of MAPK.	Cadmium	80-82	cyclin D1	Homo sapiens	329-338
33818655-5	2021	In addition, Cd-exposed cells showed higher expression of pMAPK44/42, FOXM1, pAurora B, H3ser10ph, and Cyclin D1 by western blotting.	Cadmium	13-15	cyclin D1	Homo sapiens	103-112
33818655-6	2021	Immunoprecipitation and proximity ligation assays further indicated an association between FOXM1 and Cyclin D1 in Cd-exposed cells.	Cadmium	114-116	cyclin D1	Homo sapiens	101-110
33818655-8	2021	In summary, Cd-induced proliferation of ht-UtLM cells occurred through activation of Histone H3 and Aurora B via FOXM1/Cyclin D1 interactions downstream of MAPK.	Cadmium	12-14	cyclin D1	Homo sapiens	119-128
33770575-3	2021	METHODS: In this phase II trial, patients with advanced AM with CDK4 or/and CCND1 gain or/and CDKN2A loss were treated with oral palbociclib (125 mg) on days 1-21 of a 28-day cycle.	palbociclib	129-140	cyclin D1	Homo sapiens	76-81
33821368-11	2021	Ozone induced G2/M phase cell cycle arrest, which could be elucidated by the change of protein levels of p53, p21, Cyclin D1, cyclin B1, cdc2, and CDK4.	Ozone	0-5	cyclin D1	Homo sapiens	115-124
33822184-11	2021	protein kinase C betaI, cyclin D1 and matrix metalloproteinase-9 were modulated in response to treatment with icariin.	icariin	110-117	cyclin D1	Homo sapiens	24-33
33807148-7	2021	The two most potent derivatives, isobutyrylshikonin (IBS) and alpha-methylbutyrylshikonin (MBS), induced cell cycle disturbances and apoptosis, inhibited proliferation, and decreased expression of phospho-STAT3 and downstream-regulated molecules in BCL1 and JVM-13 cells.	isobutyrylshikonin	33-51	cyclin D1	Homo sapiens	249-253
33807148-7	2021	The two most potent derivatives, isobutyrylshikonin (IBS) and alpha-methylbutyrylshikonin (MBS), induced cell cycle disturbances and apoptosis, inhibited proliferation, and decreased expression of phospho-STAT3 and downstream-regulated molecules in BCL1 and JVM-13 cells.	isobutyrylshikonin	53-56	cyclin D1	Homo sapiens	249-253
33807148-7	2021	The two most potent derivatives, isobutyrylshikonin (IBS) and alpha-methylbutyrylshikonin (MBS), induced cell cycle disturbances and apoptosis, inhibited proliferation, and decreased expression of phospho-STAT3 and downstream-regulated molecules in BCL1 and JVM-13 cells.	alpha-methylbutyrylshikonin	62-89	cyclin D1	Homo sapiens	249-253
33807148-9	2021	The link between the decrease in phosphorylated STAT3 by MBS and IBS and BCL1 cell death was confirmed by detection of enhanced cell death after addition of AG490, an inhibitor of Jak2 kinase.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	157-162	cyclin D1	Homo sapiens	73-77
33807122-5	2021	A western blot analysis demonstrated the use of trametinib alone and trametinib in combination with ribociclib to decrease the expression of pERK, cMyc, Chk1, pChk2, pCDK1, CyclinD1, and c-myc in a time-dependent manner in NCI-H727 and QGP-1 cells.	trametinib	69-79	cyclin D1	Homo sapiens	173-181
32886819-7	2021	In addition, crocin was also participated in a halting of the proteins related to cell cycle, cyclin D1, and pro-apoptotic proteins; Bax and caspase-3 expression, together with the elevation of anti-apoptotic factor Bcl-2.	crocin	13-19	cyclin D1	Homo sapiens	94-103
33764958-7	2021	Dampened cell proliferation level, arrested cell cycle, reduced protein expressions of cyclin D1 and cyclin D2, and promoted cell apoptosis level were observed after SU-DHL-4 was transfected with ShRNA-CHI3L1-1.	su-dhl-4	166-174	cyclin D1	Homo sapiens	87-96
33236129-8	2021	Furthermore, the proliferation inhibitory effect of CECU was due to the inactivation of AKT and ERK signaling, upregulation of p53 and p21, and downregulation of cyclin B1 and cyclin D1, but not reactive oxygen species (ROS) generation.	cecu	52-56	cyclin D1	Homo sapiens	176-185
33236151-0	2021	miR-576-3p overexpression enhances cisplatin sensitivity of ovarian cancer cells by dysregulating PD-L1 and cyclin D1.	mir-576-3p	0-10	cyclin D1	Homo sapiens	108-117
33236151-0	2021	miR-576-3p overexpression enhances cisplatin sensitivity of ovarian cancer cells by dysregulating PD-L1 and cyclin D1.	Cisplatin	35-44	cyclin D1	Homo sapiens	108-117
27667548-5	2016	Furthermore, baicalein blocked the TNF-alpha-induced expression of NF-kappaB target genes involved in anti-apoptosis (cIAP-1, cIAP-2, FLIP and BCL-2), proliferation (COX-2, cyclin D1 and c-Myc), invasion (MMP-9), angiogenesis (VEGF) and major inflammatory cytokines (IL-8 and MCP1).	baicalein	13-22	cyclin D1	Homo sapiens	173-182
10583923-3	1999	The authors" series of 26 small B-cell lymphomas, analyzed for the cyclin D1 protein by paraffin immunohistochemistry and for t(11;14) by polymerase chain reaction, is included.	Paraffin	88-96	cyclin D1	Homo sapiens	67-76
26743134-5	2016	Increased nuclear STAT3, p-STAT3 and its downstream target proteins, cyclin D1, vimentin and MMP2, were shown to be underling mechanisms of high glucose stimulation.	Glucose	145-152	cyclin D1	Homo sapiens	69-78
34645649-7	2022	CCND1 levels were decreased c.20% by letrozole at 2 and 14 weeks but showed a tendency to increase with palbociclib.	Letrozole	37-46	cyclin D1	Homo sapiens	0-5
34592353-8	2022	Further, we combined panobinostat with Ad-hepaCAM, which resulted in significantly increased antitumor activity and significant attenuation of the proliferation-associated genes CCND1 and PCNA compared to each single treatment.	Panobinostat	21-33	cyclin D1	Homo sapiens	178-183
34592353-9	2022	In conclusion, panobinostat may enhance the acetylation of lys9 of histone 3 and reverse the hepaCAM expression through its inhibitory effect on HDACs activity in PCa LNCaP and DU145 cells; Ad-hepaCAM combined with panobinostat may synergistically inhibit the growth of LNCaP and DU145 cells, via a potential mechanism associated with the down-regulation of the expression of CCND1 and PCNA.	Panobinostat	15-27	cyclin D1	Homo sapiens	376-381
34468993-10	2022	Taken together, the key findings of our study demonstrate that circ-E2F3 induces inhibition of miR-296-5p, which triggers activation and nuclear translocation of STAT3 that then upregulates cyclin D1 expression.	mir-296-5p	95-105	cyclin D1	Homo sapiens	190-199
34815754-11	2022	Notably, Pg-LPS significantly upregulated the expression levels of cyclins D1, A and B1 after 24 h compared with those in the controls.	pg-lps	9-15	cyclin D1	Homo sapiens	67-87
34815754-12	2022	Overall, the present study indicated that Pg-LPS may enhance the proliferation of hPDLCs, potentially through upregulation of cyclins D1, A and B1.	pg-lps	42-48	cyclin D1	Homo sapiens	126-146
34953275-0	2021	miR-6769b-5p targets CCND-1 to regulate proliferation in cadmium-treated placental trophoblasts: Association with the impairment of fetal growth.	Cadmium	57-64	cyclin D1	Homo sapiens	21-27
34871739-0	2022	Identification of cyclin D1 as a major modulator of 3-nitropropionic acid-induced striatal neurodegeneration.	3-nitropropionic acid	52-73	cyclin D1	Homo sapiens	18-27
34954029-5	2022	Olaparib induced the feedback overexpression of PARP1, FOXM1, CDC25A, CCND1, CDK1, CCNA2, CCNB1, CDC25B, BRCA1/2 and Rad51 to promote the acceleration of cell mitosis and recovery of DNA repair, which caused the generation of adaptive resistance.	olaparib	0-8	cyclin D1	Homo sapiens	70-75
34933671-12	2021	Furthermore, we found significant correlations of DNA methylation of specific CpG sites with response to the FGFR1/3-selective inhibitors PD 173074 and AZD4547, predominantly within the transcription start site of CCND1.	PD 173074	138-147	cyclin D1	Homo sapiens	214-219
34933671-12	2021	Furthermore, we found significant correlations of DNA methylation of specific CpG sites with response to the FGFR1/3-selective inhibitors PD 173074 and AZD4547, predominantly within the transcription start site of CCND1.	AZD4547	152-159	cyclin D1	Homo sapiens	214-219
34923957-16	2021	GLA reduced the expression of cell cycle-related proteins CCNB1, CCND1, CCND2, and CCND3 and increased the expression of p21 in MM cell lines.	glaucocalyxin A	0-3	cyclin D1	Homo sapiens	65-70
34937659-7	2022	Furthermore, NTZ downregulated Wnt/beta-catenin signaling pathway through significant decrease of CTNNB1, c-Myc, ABCB1, and cyclin D1 genes and resulted in drug resistance reversal and inhibition of cell proliferation.	nitazoxanide	13-16	cyclin D1	Homo sapiens	124-133
34944712-9	2021	GSEA indicated that individuals with the increased levels of miR-154 had upregulated AKT-MTOR, CYCLIN D1, KRAS, EIF4E, RB, ATM, and EMT gene sets.	gsea	0-4	cyclin D1	Homo sapiens	95-104
34956872-10	2021	6-TG and 6-MP had effects on several cell cycle proteins, including another USP2a target protein, cyclin D1.	Thioguanine	0-4	cyclin D1	Homo sapiens	98-107
34956872-10	2021	6-TG and 6-MP had effects on several cell cycle proteins, including another USP2a target protein, cyclin D1.	Mercaptopurine	9-13	cyclin D1	Homo sapiens	98-107
34866251-6	2022	We further revealed the molecular mechanism by which nuclear-localized GHR regulates MSCs proliferation, and found that nuclear-targeted GHR enhanced the phosphorylation of STAT5, and the activated STAT5 initiates the transcription of CyclinD1, after which, the complex of CyclinD1 and CDK4 further phosphorylates Rb, and the activated Rb releases E2F1, the released E2F1 ultimately realizes the biological function of GH promoting cell proliferation.	Rubidium	314-316	cyclin D1	Homo sapiens	235-243
34866251-6	2022	We further revealed the molecular mechanism by which nuclear-localized GHR regulates MSCs proliferation, and found that nuclear-targeted GHR enhanced the phosphorylation of STAT5, and the activated STAT5 initiates the transcription of CyclinD1, after which, the complex of CyclinD1 and CDK4 further phosphorylates Rb, and the activated Rb releases E2F1, the released E2F1 ultimately realizes the biological function of GH promoting cell proliferation.	Rubidium	314-316	cyclin D1	Homo sapiens	273-281
34899944-11	2021	Conclusion: The possible mechanisms of the components of the Zhishi-Baizhu herb pair in treating gastric cancer might be related to luteolin and naringenin, which intervened with the targets AKT1, MMP9, IL-6, CCND1, BCL2, MTOR, and MDM2, and are linked with the PI3K-Akt and IL-17 signaling pathways.	naringenin	145-155	cyclin D1	Homo sapiens	209-214
34806539-1	2021	We aimed to analyze the expression of Cyclin D1 (CCND1) gene in ovarian cancer and the influence of silencing its expression on ovarian cancer cells based on the Oncomine database.	oncomine	162-170	cyclin D1	Homo sapiens	38-47
34806539-1	2021	We aimed to analyze the expression of Cyclin D1 (CCND1) gene in ovarian cancer and the influence of silencing its expression on ovarian cancer cells based on the Oncomine database.	oncomine	162-170	cyclin D1	Homo sapiens	49-54
34806539-2	2021	The expression of CCND1 gene in ovarian cancer was analyzed by utilizing the relevant information in different tumors and Oncomine database.	oncomine	122-130	cyclin D1	Homo sapiens	18-23
34281460-11	2021	LINC0163 silencing activated Axin2 while suppressing the expressions of beta-catenin, Cyclin-D1 and c-MYC.	linc0163	0-8	cyclin D1	Homo sapiens	86-95
34519612-9	2021	In U251 and SHG-44 cells, with chrysophanol concentration rising, cell viability, expressions of Cyclin D1 and Cyclin E were decreased while cell apoptosis, levels of cleaved caspase-3, cleaved caspase-9 and Cytosol Cyt C as well as ROS accumulation were increased with cell cycle arrested in G1 phase.	chrysophanic acid	31-43	cyclin D1	Homo sapiens	97-106
34696683-7	2021	Ropivacaine challenge also arrested cells in the G2 phase, followed by a decline in the protein expression of cyclin D1 and cyclin-dependent kinase 2, and an increase in p27 levels in HepG2 cells.	Ropivacaine	0-11	cyclin D1	Homo sapiens	110-119
34224057-8	2021	Overexpression of MGC27382 prevented NSCLC cell proliferation via down-regulating cyclin D1 and cyclin E. Moreover, wound healing and transwell assays indicated that the ability of cell invasion and migration could be impaired when cells were treated with MGC27382 overexpression.	mgc27382	18-26	cyclin D1	Homo sapiens	82-91
34224057-8	2021	Overexpression of MGC27382 prevented NSCLC cell proliferation via down-regulating cyclin D1 and cyclin E. Moreover, wound healing and transwell assays indicated that the ability of cell invasion and migration could be impaired when cells were treated with MGC27382 overexpression.	mgc27382	256-264	cyclin D1	Homo sapiens	82-91
34584036-6	2021	We identified ursolic acid in MRBE through LC/mass spectrum (MS) and observed that it also decreased intracellular beta-catenin, c-myc, and cyclin D1 levels.	ursolic acid	14-26	cyclin D1	Homo sapiens	140-149
34653428-9	2021	Treatment with palmitic acid induced G1 phase arrest, which was associated with downregulation of cyclin D1 and p-Rb and upregulation of p27.	Palmitic Acid	15-28	cyclin D1	Homo sapiens	98-116
34555425-4	2021	Testosterone rapidly activated inhibitory G protein signaling, Erk, and Akt, and inhibition of these signaling members abrogated the ZIP9-mediated cyclin D1 and proliferative responses.	Testosterone	0-12	cyclin D1	Homo sapiens	147-156
34866998-11	2021	Our research findings shown that there was a decline in activity of superoxide dismutase, glutathione peroxidase and glutathione s transferase in addition, personal habits like smoking play a major role in the development and progression of oral carcinogenesis and based on Insilco analysis results CCND1/Cyclin D1 could be the potential therapeutic target in oral squamous cell carcinoma.	Superoxides	68-78	cyclin D1	Homo sapiens	299-304
34866998-11	2021	Our research findings shown that there was a decline in activity of superoxide dismutase, glutathione peroxidase and glutathione s transferase in addition, personal habits like smoking play a major role in the development and progression of oral carcinogenesis and based on Insilco analysis results CCND1/Cyclin D1 could be the potential therapeutic target in oral squamous cell carcinoma.	Glutathione	90-101	cyclin D1	Homo sapiens	299-304
34837150-9	2022	In contrast, si-GSK-3beta inhibited the proliferation of HUVECs and the expression of cyclinD1 and PCNA.	Silicon	13-15	cyclin D1	Homo sapiens	86-94
34916197-7	2021	Treatment with lactate obviously up-regulated the expressions of cyclin D1, cyclin E1, PCNA, N-cadherin, MMP-2, MMP-9 and HMGB1, which were significantly inhibited by aloin; aloin significantly reversed inhibition of E-cadherin and blocked the release of HMGB1 in lactate-treated cells.	alloin	167-172	cyclin D1	Homo sapiens	65-74
34916197-7	2021	Treatment with lactate obviously up-regulated the expressions of cyclin D1, cyclin E1, PCNA, N-cadherin, MMP-2, MMP-9 and HMGB1, which were significantly inhibited by aloin; aloin significantly reversed inhibition of E-cadherin and blocked the release of HMGB1 in lactate-treated cells.	Lactic Acid	15-22	cyclin D1	Homo sapiens	65-74
34916197-7	2021	Treatment with lactate obviously up-regulated the expressions of cyclin D1, cyclin E1, PCNA, N-cadherin, MMP-2, MMP-9 and HMGB1, which were significantly inhibited by aloin; aloin significantly reversed inhibition of E-cadherin and blocked the release of HMGB1 in lactate-treated cells.	alloin	174-179	cyclin D1	Homo sapiens	65-74
34809976-12	2022	Cell cycle markers, including C-MYC (5 muM SAHA, FC = 0.828) and CCND1 (5 muM SAHA, FC = 0.583; 10 muM SAHA, FC = 0.482), were significantly down-regulated after SAHA treatment.	Vorinostat	78-82	cyclin D1	Homo sapiens	65-70
34809976-12	2022	Cell cycle markers, including C-MYC (5 muM SAHA, FC = 0.828) and CCND1 (5 muM SAHA, FC = 0.583; 10 muM SAHA, FC = 0.482), were significantly down-regulated after SAHA treatment.	Vorinostat	162-166	cyclin D1	Homo sapiens	65-70
34293698-0	2021	Platinum complexes inhibit HER-2 enriched and triple-negative breast cancer cells metabolism to suppress growth, stemness and migration by targeting PKM/LDHA and CCND1/BCL2/ATG3 signaling pathways.	Platinum	0-8	cyclin D1	Homo sapiens	162-167
34906046-6	2021	The identified targets of these two steroids are the genes of the proteins Ki67, cyclin D1, PCNA, and p21.	Steroids	36-44	cyclin D1	Homo sapiens	81-90
34909046-11	2022	Furthermore, PEI-PEG-loaded CD44 siRNA reduces the expression of cyclin D1 and CKD-4.	pei-peg	13-20	cyclin D1	Homo sapiens	65-74
34805140-3	2021	In the present study, we found that photodynamic therapy (PDT) treatment inhibited gemcitabine-resistant cholangiocarcinoma cells via repressing cell viability, enhancing cell apoptosis, and eliciting G1 cell cycle arrest through modulating Cyclin D1 and caspase 3 cleavage.	gemcitabine	83-94	cyclin D1	Homo sapiens	241-250
34365218-5	2021	Further, majority of the non-platinum drugs except irinotecan increased ERK1/2 activation in platinum-taxol resistant cells as observed by live-cell BRET assessment which were associated with p90RSK1/2 and BAD activation along with upregulation of multidrug transporter gene ABCC1 and cell survival genes like cyclin D1 and Bcl2.	Platinum	29-37	cyclin D1	Homo sapiens	310-319
34233525-5	2021	The expression of cyclin D1 in megestrol acetate treated cells was downregulated, while the expressions of p21 and p16 were upregulated via PR-B isoform.	Megestrol Acetate	31-48	cyclin D1	Homo sapiens	18-27
34514729-9	2021	Further investigations revealed that crocetin treatment inhibited the expression of STAT3 regulated genes (Bcl-2, Bcl-xL, cyclin D1, survivin, VEGF, COX-2, and MMP-9).	crocetin	37-45	cyclin D1	Homo sapiens	122-131
34673711-4	2021	We aimed to evaluate the utility of cyclin D1 and BCOR immunohistochemistry in differentiating CCSK from its morphologic mimics.	ccsk	95-99	cyclin D1	Homo sapiens	36-45
34673711-8	2021	Strong, diffuse nuclear immunoreactivity for cyclin D1 and BCOR was noted in 61% (n=11/18) and 83% (n=15/18) of CCSK, respectively, while it was significantly less in WT (n=3/10 for cyclin D1) (n=2/10 for BCOR).	ccsk	112-116	cyclin D1	Homo sapiens	45-54
34673711-11	2021	CONCLUSION: Our results provide evidence that concurrent immunopositivity with cyclin D1 and BCOR is helpful in distinguishing CCSK from its morphologic mimics.	ccsk	127-131	cyclin D1	Homo sapiens	79-88
34500061-0	2021	Nannocystin ax, an eEF1A inhibitor, induces G1 cell cycle arrest and caspase-independent apoptosis through cyclin D1 downregulation in colon cancer in vivo.	nannocystin ax	0-14	cyclin D1	Homo sapiens	107-116
34500061-5	2021	NAN significantly downregulated cyclin D1 level in a short time, but NAN did not affect the transcription level and ubiquitin-dependent degradation of cyclin D1.	nan	0-3	cyclin D1	Homo sapiens	32-41
34500061-6	2021	Furthermore, NAN treatment directly targeted eEF1A and partially decreased the synthesis of new proteins, contributing to the downregulation of cyclin D1.	nan	13-16	cyclin D1	Homo sapiens	144-153
34500061-8	2021	In conclusion, NAN triggered G1 phase cell cycle arrest through cyclin D1 downregulation and eEF1A-targeted translation inhibition and promoted caspase-independent apoptosis in CRC cells.	nan	15-18	cyclin D1	Homo sapiens	64-73
34365218-5	2021	Further, majority of the non-platinum drugs except irinotecan increased ERK1/2 activation in platinum-taxol resistant cells as observed by live-cell BRET assessment which were associated with p90RSK1/2 and BAD activation along with upregulation of multidrug transporter gene ABCC1 and cell survival genes like cyclin D1 and Bcl2.	Irinotecan	51-61	cyclin D1	Homo sapiens	310-319
34365218-5	2021	Further, majority of the non-platinum drugs except irinotecan increased ERK1/2 activation in platinum-taxol resistant cells as observed by live-cell BRET assessment which were associated with p90RSK1/2 and BAD activation along with upregulation of multidrug transporter gene ABCC1 and cell survival genes like cyclin D1 and Bcl2.	Platinum	93-101	cyclin D1	Homo sapiens	310-319
34365218-5	2021	Further, majority of the non-platinum drugs except irinotecan increased ERK1/2 activation in platinum-taxol resistant cells as observed by live-cell BRET assessment which were associated with p90RSK1/2 and BAD activation along with upregulation of multidrug transporter gene ABCC1 and cell survival genes like cyclin D1 and Bcl2.	Paclitaxel	102-107	cyclin D1	Homo sapiens	310-319
34829591-4	2021	DHA suppressed the expression of phosphorylated-Rb (p-Rb), cyclin D1, cyclin E, cyclin A, E2F1 and c-Myc proteins.	dehydroacetic acid	0-3	cyclin D1	Homo sapiens	59-68
34707101-0	2021	NRIP1 is activated by C-JUN/C-FOS and activates the expression of PGR, ESR1 and CCND1 in luminal A breast cancer.	Phenobarbital	89-96	cyclin D1	Homo sapiens	80-85
34707101-6	2021	NRIP1 is not only upregulated in luminal A patients and cell lines but also regulates breast cancer-related genes, including PR, ESR1 and CCND1.	Phenobarbital	33-40	cyclin D1	Homo sapiens	138-143
34633777-11	2021	Additionally, BIX01294 downregulated the expressions of cell cycle proteins, cyclin D1, CDK4, and P21, but upregulated the expressions of apoptosis-related proteins, Bax and caspase-3.	BIX 01294	14-22	cyclin D1	Homo sapiens	77-86
34669157-4	2021	Mechanically, the combination of rapamycin with cabozantinib resulted in the remarkable inhibition of AKT, extracellular signal-regulated protein kinases, mTOR, and common downstream signal molecules of receptor tyrosine kinases; decreased cyclin D1 expression; and induced cell cycle arrest.	Sirolimus	33-42	cyclin D1	Homo sapiens	240-249
34669157-4	2021	Mechanically, the combination of rapamycin with cabozantinib resulted in the remarkable inhibition of AKT, extracellular signal-regulated protein kinases, mTOR, and common downstream signal molecules of receptor tyrosine kinases; decreased cyclin D1 expression; and induced cell cycle arrest.	cabozantinib	48-60	cyclin D1	Homo sapiens	240-249
34480853-9	2021	Hypoxia and pamidronate decreased the number of OFMSCs positive for primary cilia that was consistent with increased HIF-1alpha and caspase 3 but decreased cyclin D1.	Pamidronate	12-23	cyclin D1	Homo sapiens	156-165
34786070-5	2021	Simultaneously, DCZ0858 activated caspase family proteins, blocked MM cells in G0/G1 phase, and reduced the expression of related cyclins CDK4/6 and CyclinD1.	dcz0858	16-23	cyclin D1	Homo sapiens	149-157
34626304-0	2021	Novel B, C-ring truncated deguelin derivatives reveals as potential inhibitors of cyclin D1 and cyclin E using molecular docking and molecular dynamic simulation.	deguelin	26-34	cyclin D1	Homo sapiens	82-91
34174548-12	2021	CONCLUSION: MiR-135a-5p suppresses VSMCs proliferation and migration induced by ox-LDL via targeting and activating FOXO1/Cyclin D1 and JAK2/STAT3 signaling pathways.	mir-135a-5p	12-23	cyclin D1	Homo sapiens	122-131
34076332-6	2021	Furthermore ELISA and real time PCR reaction determined that brucine were down regulated inflammatory (TNF-alpha, NF-kB, IL-6 & COX-2) cell proliferation (Cyclin D1) and apoptotic marker Bax, caspase-3, PI3K (phosphoinosital 3 kinase), AKT, mTOR (mammalian target of rapamycin) and over expression Bcl-2, associated death promoter.	brucine	61-68	cyclin D1	Homo sapiens	155-164
34080770-0	2021	miR-486-3p regulates CyclinD1 and promotes fluoride-induced osteoblast proliferation and activation.	mir-486-3p	0-10	cyclin D1	Homo sapiens	21-29
34080770-4	2021	On the basis of our previous miRNA-seq results and bioinformatics analysis, this study investigated the role and specific molecular mechanism of miR-486-3p in fluoride-induced osteoblast proliferation and activation via CyclinD1.	mir-486-3p	145-155	cyclin D1	Homo sapiens	220-228
34080770-4	2021	On the basis of our previous miRNA-seq results and bioinformatics analysis, this study investigated the role and specific molecular mechanism of miR-486-3p in fluoride-induced osteoblast proliferation and activation via CyclinD1.	Fluorides	159-167	cyclin D1	Homo sapiens	220-228
34080770-5	2021	Herein, in the fluoride-challenged population, we observed that miR-486-3p expression decreased while CyclinD1 and transforming growth factor (TGF)-beta1 increased, and miR-486-3p level correlated negatively with the expression of CyclinD1 and TGF-beta1 genes.	Fluorides	15-23	cyclin D1	Homo sapiens	102-110
34080770-5	2021	Herein, in the fluoride-challenged population, we observed that miR-486-3p expression decreased while CyclinD1 and transforming growth factor (TGF)-beta1 increased, and miR-486-3p level correlated negatively with the expression of CyclinD1 and TGF-beta1 genes.	Fluorides	15-23	cyclin D1	Homo sapiens	231-239
34080770-5	2021	Herein, in the fluoride-challenged population, we observed that miR-486-3p expression decreased while CyclinD1 and transforming growth factor (TGF)-beta1 increased, and miR-486-3p level correlated negatively with the expression of CyclinD1 and TGF-beta1 genes.	mir-486-3p	169-179	cyclin D1	Homo sapiens	231-239
34080770-7	2021	Meanwhile, we demonstrated that miR-486-3p regulates NaF-induced upregulation of CyclinD1 by directly targeting its 3"-untranslated region (3"-UTR).	mir-486	32-39	cyclin D1	Homo sapiens	81-89
34080770-7	2021	Meanwhile, we demonstrated that miR-486-3p regulates NaF-induced upregulation of CyclinD1 by directly targeting its 3"-untranslated region (3"-UTR).	p-Bis(2-chloroethyl)amino-o-methoxyphenylalanine	40-42	cyclin D1	Homo sapiens	81-89
34165231-7	2021	MEHP exposure can up-regulate the expression of C-MYC, Cyclin D1, Bcl-2 and affected the Notch pathway.	mono-(2-ethylhexyl)phthalate	0-4	cyclin D1	Homo sapiens	55-64
34516453-13	2021	The overexpression of miR-377-3p inhibited proliferation, migration, and inflammation while induced apoptosis of VSMCs by targeting CCND1.	mir-377-3p	22-32	cyclin D1	Homo sapiens	132-137
34466064-8	2021	Cell cycle analysis revealed that Tilianin treatment prevented G1/S transition through reduced mRNA expression of cyclin D1.	tilianin	34-42	cyclin D1	Homo sapiens	114-123
34466065-9	2021	Dieckol also regulated the proliferative (cyclin D1), inflammatory (COX-2, IL-6, TNF-alpha, and NF-kappaB), and apoptotic (caspase-3, Bax, Bcl-2) markers in the MG-63 cells.	dieckol	0-7	cyclin D1	Homo sapiens	42-51
34539418-11	2021	Cyclin D1 was involved in the anticancer effects of alpha-Mangostin on the cell cycle in MDA-MB-231 cells.	mangostin	52-67	cyclin D1	Homo sapiens	0-9
34539418-12	2021	alpha-Mangostin induces apoptosis, suppresses the migration and invasion of breast cancer cells through the PI3K/AKT signaling pathway by targeting RXRalpha, and cyclin D1 has involved in this process.	mangostin	0-15	cyclin D1	Homo sapiens	162-171
34429133-11	2021	Apatinib induced cell cycle arrest at G1 phase and suppressed the expression of Cyclin D1 and CDK4.	apatinib	0-8	cyclin D1	Homo sapiens	80-89
34901534-6	2022	When HL-60 cells were treated by Au@Ce NPs, the removal of endogenous ROS signal significantly arrested cell cycle at G1 phase and suppressed the cell proliferation by blocking the mitogen-activated protein kinases (MAPKs) signaling and the Akt/Cyclin D1 cell cycle signaling.	ros	70-73	cyclin D1	Homo sapiens	245-254
34483932-6	2021	Overexpression of USP5 could significantly extend the half-life of CyclinD1, while knockdown of USP5 decreased the protein level of CyclinD1, which could be restored by proteasome inhibitor MG-132.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	190-196	cyclin D1	Homo sapiens	67-75
34483932-6	2021	Overexpression of USP5 could significantly extend the half-life of CyclinD1, while knockdown of USP5 decreased the protein level of CyclinD1, which could be restored by proteasome inhibitor MG-132.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	190-196	cyclin D1	Homo sapiens	132-140
34385584-9	2021	The resistance to both palbociclib and abemaciclib was associated with the strong upregulation of CDK6 and CCND1 protein levels, which was reversed by the ZEN-3694 treatment.	zen	155-158	cyclin D1	Homo sapiens	107-112
34373562-7	2021	The NTAPP treatment increased the expression levels of Wnt/beta-catenin pathway-related genes (AMER3, CCND1, LEF1, and LRG1) and proteins (beta-catenin, p-GSK3beta, and cyclin D1) in human DP cells.	Plasma Gases	4-9	cyclin D1	Homo sapiens	102-107
34373562-7	2021	The NTAPP treatment increased the expression levels of Wnt/beta-catenin pathway-related genes (AMER3, CCND1, LEF1, and LRG1) and proteins (beta-catenin, p-GSK3beta, and cyclin D1) in human DP cells.	Plasma Gases	4-9	cyclin D1	Homo sapiens	169-178
34373562-8	2021	In contrast, inhibitors of Wnt/beta-catenin signaling, endo-IWR1 and IWP2, attenuated the levels of cyclin D1, p-GSK3beta, and beta-catenin proteins induced by NTAPP.	Plasma Gases	160-165	cyclin D1	Homo sapiens	100-109
34373562-9	2021	Furthermore, we observed that NTAPP induced the activation of beta-catenin in DP cells of hair follicles and the mRNA levels of target genes of the beta-catenin signaling pathway (CCND1, LEF1, and TCF4).	Plasma Gases	30-35	cyclin D1	Homo sapiens	180-185
34445227-5	2021	Osimertinib exerted significant inhibitory effects on cell growth and cell cycle progression by promoting the phosphorylation of p53 and p21 and decreasing cyclin D1 expression independently of EGFR.	osimertinib	0-11	cyclin D1	Homo sapiens	156-165
34338265-6	2021	Further study showed that the protective effect of kaempferol was associated with an enhanced mRNA level of genes related to cell cycle progression (cyclin D1, CDK4, and E2F1) and genes implicated in the anti-oxidant system (GSR, GSTA4, and HO-1), up-regulated abundance of tight junctions (ZO-1, ZO-2, occludin, and claudin-4), as well as enhanced Nrf2, an anti-oxidant transcription factor.	kaempferol	51-61	cyclin D1	Homo sapiens	149-158
34349346-4	2021	By introducing the Dox-inducible lentiviral vector into human airway epithelial cells, we established a novel human airway epithelial cell line harboring polycistronic Dox-inducible CDK4R24C and Cyclin D1, referred to as Tet-on K4D cells.	Doxycycline	19-22	cyclin D1	Homo sapiens	195-204
34349346-4	2021	By introducing the Dox-inducible lentiviral vector into human airway epithelial cells, we established a novel human airway epithelial cell line harboring polycistronic Dox-inducible CDK4R24C and Cyclin D1, referred to as Tet-on K4D cells.	Doxycycline	168-171	cyclin D1	Homo sapiens	195-204
34349346-4	2021	By introducing the Dox-inducible lentiviral vector into human airway epithelial cells, we established a novel human airway epithelial cell line harboring polycistronic Dox-inducible CDK4R24C and Cyclin D1, referred to as Tet-on K4D cells.	tetramethylenedisulfotetramine	221-224	cyclin D1	Homo sapiens	195-204
34639115-6	2021	It also decreased LPA-induced cell proliferation and cell cycle progression via increased cyclin A2, cyclin D1, cyclin-dependent kinase (CDK)2, and CDK4 expression and decreased p27Kip1 expression in HaCaT cells.	lysophosphatidic acid	18-21	cyclin D1	Homo sapiens	101-110
34098017-10	2021	CTNNB1, CCND1 and SMAD4 were identified as synergistic targets inhibited by PUE-GLY.	pue-gly	76-83	cyclin D1	Homo sapiens	8-13
34233590-8	2021	In addition, curcumin significantly inhibited the protein expression of IL-6R, STAT3, snail, survivin, and cyclin D1 in THLE-2 and HepG2 cells induced by IL-6.	Curcumin	13-21	cyclin D1	Homo sapiens	107-116
34638959-4	2021	Moreover, Morusin significantly increased G1 arrest, attenuated the expression of cyclin D1, cyclin D3, cyclin E, cyclin-dependent kinase 2 (CDK2), cyclin-dependent kinase 4 (CDK4), and cyclin-dependent kinase 6 (CDK6) and upregulated p21 and p27 in Hep3B and Huh7 cells.	morusin	10-17	cyclin D1	Homo sapiens	82-91
34603448-11	2021	DiAcSpm treatment increased levels of proliferation, cell cycle progression, and cyclin D1 and cyclin E proteins in CRC cell lines, SW480 and Caco-2.	diacspm	0-7	cyclin D1	Homo sapiens	81-90
34575112-4	2021	Calcitriol reduced the expression of cyclin D1 and c-Myc.	Calcitriol	0-10	cyclin D1	Homo sapiens	37-46
34146926-7	2021	Delta9-THC and Delta8-THC also downregulated cyclin D1, p53, NOXA, PUMAalpha, and DRAM expressions but increased p21 and H2AX expression.	Dronabinol	7-10	cyclin D1	Homo sapiens	45-54
34331612-13	2021	HCP5 promoted cell proliferation and tumor formation of MM cells by activating the Wnt/beta-catenin/CCND1 signaling pathway by sponging miR-128-3p to increase PLAGL2 expression.	mir-128-3p	136-146	cyclin D1	Homo sapiens	100-105
34146662-7	2021	Also, atrazine blocked the NSC cell cycle G1 phase via down-regulating CCND1, CDK2, and CDK4, with no obvious effect on apoptosis.	Atrazine	6-14	cyclin D1	Homo sapiens	71-76
34362486-10	2021	The proliferation of Nalm6 cells and the number of cell clones could be inhibited by miR-142-3p mimic after 48 and 72 hours of transfection (P<0.05), which causing G1 phase arrest of Nalm6 cells and inhibiting the expression of CyclinD1 and CDK4 protein (P<0.01), promoting the apoptosis of Nalm6 cells, and inhibiting the expression of BCL-2 protein, moreover, promoting the expression of Bax and Caspase-3 protein (P<0.05).	mir-142-3p	85-95	cyclin D1	Homo sapiens	228-236
34361036-5	2021	Hinokitiol significantly suppressed cell proliferation through the inhibition of the expression of cell-cycle mediators, such as cyclin D1 and cyclin-dependent kinase 4 (CDK4), as well as the induction of the tumor suppressor protein p53.	beta-thujaplicin	0-10	cyclin D1	Homo sapiens	129-138
34169322-5	2021	Bcl-xL, c-Myc, and Cyclin D1 were downregulated after treatment with SP2509.	SP2509	69-75	cyclin D1	Homo sapiens	19-28
34315394-8	2022	Significant suppression of Cyclin D1 gene expression was noted in MDA-MB-231 and MCF-7 cells treated with P. capillacea or C. officinalis polysaccharides.	Polysaccharides	138-153	cyclin D1	Homo sapiens	27-36
34354858-9	2021	Western blot analyses indicated that several cell cycle-related proteins, including cyclin D1, p21, and DNA damage inducible transcript 4 (DDIT4), were further modulated by doxycycline and gemcitabine co-treatment.	Doxycycline	173-184	cyclin D1	Homo sapiens	84-93
34354858-9	2021	Western blot analyses indicated that several cell cycle-related proteins, including cyclin D1, p21, and DNA damage inducible transcript 4 (DDIT4), were further modulated by doxycycline and gemcitabine co-treatment.	gemcitabine	189-200	cyclin D1	Homo sapiens	84-93
34230134-8	2021	Induction of p21, and caspase-3, -8, and -9 cleavages, while down-regulation of cyclin B1 and cyclin D1 were observed in TOFA-treated cells.	5-(tetradecyloxy)-2-furancarboxylic acid	121-125	cyclin D1	Homo sapiens	94-103
34146926-7	2021	Delta9-THC and Delta8-THC also downregulated cyclin D1, p53, NOXA, PUMAalpha, and DRAM expressions but increased p21 and H2AX expression.	Dronabinol	22-25	cyclin D1	Homo sapiens	45-54
34158560-10	2021	Finally, anethole treatment inhibits the expression of oncogenes (cyclin D1) and up-regulated cyclin-dependent kinase inhibitor (p21WAF1), increases the expression of p53 gene, but inhibits the epithelial-mesenchymal transition markers.	anethole	9-17	cyclin D1	Homo sapiens	66-75
34302638-3	2021	G-Rg2 significantly inhibited protein and mRNA expression of cell cycle G1-S phase regulators, including p-Rb, cyclin D1, CDK4, and CDK6, whereas it enhanced the protein and mRNA expression of cell cycle arrest and apoptotic molecules including cleaved PARP, p21, p27, p53 and Bak through ROS production.	ginsenoside Rg2	0-5	cyclin D1	Homo sapiens	111-120
34161670-8	2022	Cleaved caspases 8, 3, and 7, poly(ADP)-ribose polymerase (PARP), and the cyclin-dependent kinase (CDK) inhibitor p-Chk2 was induced by PB in HGC-27 cells, while the cell cycle-related proteins cyclin D1, cyclin D3, CDK4, CDK6, cyclin E, and phosphorylated retinoblastoma tumor suppressor protein (p-Rb) were downregulated in a dose-dependent manner.	physalin B	136-138	cyclin D1	Homo sapiens	194-203
35219784-0	2022	Tween 80 improves the infectivity of BCL1 cell-adapted infectious bursal disease virus.	Polysorbates	0-8	cyclin D1	Homo sapiens	37-41
34235153-9	2021	The in vitro results showed that the combination of metformin and pemetrexed exhibited an antiproliferative effect in reducing cell viability and colony formation, the downregulation of cyclin D1 and A2 and the upregulation of CDKN1B, which are involved in the G1/S phase.	Metformin	52-61	cyclin D1	Homo sapiens	186-195
34235153-9	2021	The in vitro results showed that the combination of metformin and pemetrexed exhibited an antiproliferative effect in reducing cell viability and colony formation, the downregulation of cyclin D1 and A2 and the upregulation of CDKN1B, which are involved in the G1/S phase.	Pemetrexed	66-76	cyclin D1	Homo sapiens	186-195
34168462-0	2021	Bergamottin Induces DNA Damage and Inhibits Malignant Progression in Melanoma by Modulating miR-145/Cyclin D1 Axis.	bergamottin	0-11	cyclin D1	Homo sapiens	100-109
34168462-13	2021	Conclusion: Thus, we conclude that BGM induces DNA damage and inhibits tumor progression in melanoma by modulating the miR-145/Cyclin D1 axis.	bergamottin	35-38	cyclin D1	Homo sapiens	127-136
34178650-0	2021	N6-Methyladenosine Associated Silencing of miR-193b Promotes Cervical Cancer Aggressiveness by Targeting CCND1.	N-methyladenosine	0-18	cyclin D1	Homo sapiens	105-110
34235224-14	2021	Oppositely, the expression of PTEN, MYC, MAPK1, UBC, and CCND1 potentially targeted by miR-20a-5p was significantly upregulated.	mir-20a-5p	87-97	cyclin D1	Homo sapiens	57-62
34199844-4	2021	We report that the CBP/p300 KAT inhibitor A-485 and the BD inhibitor GNE-049 downregulate ER, attenuate estrogen-induced c-Myc and Cyclin D1 expression, and inhibit growth of ER+ BC cells through inducing senescence.	A-485	42-47	cyclin D1	Homo sapiens	131-140
34199844-4	2021	We report that the CBP/p300 KAT inhibitor A-485 and the BD inhibitor GNE-049 downregulate ER, attenuate estrogen-induced c-Myc and Cyclin D1 expression, and inhibit growth of ER+ BC cells through inducing senescence.	GNE-049	69-76	cyclin D1	Homo sapiens	131-140
34251962-0	2021	The function and mechanism of the JARID2/CCND1 axis in modulating glioma cell growth and sensitivity to temozolomide (TMZ).	Temozolomide	104-116	cyclin D1	Homo sapiens	41-46
34251962-0	2021	The function and mechanism of the JARID2/CCND1 axis in modulating glioma cell growth and sensitivity to temozolomide (TMZ).	Temozolomide	118-121	cyclin D1	Homo sapiens	41-46
34251962-7	2021	Under TMZ treatment, JARID2 overexpression inhibited CCND1 expression, promoted glioma cell apoptosis, and increased p21, cleaved-PARP, and cleaved-caspase3 in glioma cells treated with TMZ; meanwhile, CCND1 overexpression exerted opposite effects on glioma cells treated with TMZ and partially reversed the effects of JARID2 overexpression.	Temozolomide	6-9	cyclin D1	Homo sapiens	202-207
34251962-7	2021	Under TMZ treatment, JARID2 overexpression inhibited CCND1 expression, promoted glioma cell apoptosis, and increased p21, cleaved-PARP, and cleaved-caspase3 in glioma cells treated with TMZ; meanwhile, CCND1 overexpression exerted opposite effects on glioma cells treated with TMZ and partially reversed the effects of JARID2 overexpression.	Temozolomide	186-189	cyclin D1	Homo sapiens	53-58
34251962-7	2021	Under TMZ treatment, JARID2 overexpression inhibited CCND1 expression, promoted glioma cell apoptosis, and increased p21, cleaved-PARP, and cleaved-caspase3 in glioma cells treated with TMZ; meanwhile, CCND1 overexpression exerted opposite effects on glioma cells treated with TMZ and partially reversed the effects of JARID2 overexpression.	Temozolomide	186-189	cyclin D1	Homo sapiens	202-207
34251962-7	2021	Under TMZ treatment, JARID2 overexpression inhibited CCND1 expression, promoted glioma cell apoptosis, and increased p21, cleaved-PARP, and cleaved-caspase3 in glioma cells treated with TMZ; meanwhile, CCND1 overexpression exerted opposite effects on glioma cells treated with TMZ and partially reversed the effects of JARID2 overexpression.	Temozolomide	277-280	cyclin D1	Homo sapiens	53-58
34251962-7	2021	Under TMZ treatment, JARID2 overexpression inhibited CCND1 expression, promoted glioma cell apoptosis, and increased p21, cleaved-PARP, and cleaved-caspase3 in glioma cells treated with TMZ; meanwhile, CCND1 overexpression exerted opposite effects on glioma cells treated with TMZ and partially reversed the effects of JARID2 overexpression.	Temozolomide	277-280	cyclin D1	Homo sapiens	202-207
34251962-9	2021	The JARID2/CCND1 axis modulates glioma cell growth and glioma cell sensitivity to TMZ.	Temozolomide	82-85	cyclin D1	Homo sapiens	11-16
34204881-6	2021	DFO prevented DNA damage and stress-induced senescence of hMESCs, as evidenced by reduced levels of reactive oxygen species, lipofuscin, cyclin D1, decreased SA-beta-Gal activity, and improved mitochondrial function.	Deferoxamine	0-3	cyclin D1	Homo sapiens	137-146
34092127-0	2021	Enhancing the sensitivity of ovarian cancer cells to olaparib via microRNA-20b-mediated cyclin D1 targeting.	olaparib	53-61	cyclin D1	Homo sapiens	88-97
34092127-1	2021	We previously reported that cyclin D1 silencing interferes with RAD51 accumulation and increases the sensitivity of BRCA1 wild-type ovarian cancer cells to olaparib.	olaparib	156-164	cyclin D1	Homo sapiens	28-37
34483446-0	2021	Protective Effect of Genistein on Cyclin D1 Expression in Malignant Ocular Melanoma Cells.	Genistein	21-30	cyclin D1	Homo sapiens	34-43
34483446-4	2021	Objective: This study aimed to investigate the effect of giving genistein on cyclin D1 expression in malignant melanoma.	Genistein	64-73	cyclin D1	Homo sapiens	77-86
34483446-7	2021	Results: There was a significant increase in the expression of cyclin D1, in the group given genistein 25 muM and 50 muM (p < 0.05).	Genistein	93-102	cyclin D1	Homo sapiens	63-72
34483446-8	2021	For the administration of the genistein dose of 100 muM, cyclin D1 expression decreased significantly compared to the control group (p < 0.05).	Genistein	30-39	cyclin D1	Homo sapiens	57-66
34483446-9	2021	Conclusion: It was concluded that genistein had a biphasic effect on cyclin D1 expression in malignant melanoma cells.	Genistein	34-43	cyclin D1	Homo sapiens	69-78
34070493-6	2021	Furthermore, the application of 5-ALA increased the accumulation of U87MG cells in the SUB-G1 population, decreased the expression of cyclin D1, and reduced the migration ability of U87MG cells.	5-amino levulinic acid	32-37	cyclin D1	Homo sapiens	134-143
34134955-5	2021	OBJECTIVE: Curcumol at 10, 20, 40, 80 and 160 mg/L all reduced the protein expressions of cyclin D1, PCNA and Bcl-2, inhibited the expressions of fibrotic marker proteins Col1A1, Col3A1 and alpha-SMA, decreased the levels of ERK signaling pathway proteins p-ERK1/2, p-MEK and p-c-Raf, and increased the expressions of Bax and cleaved caspase-3 proteins (P < 0.05).	curcumol	11-19	cyclin D1	Homo sapiens	90-99
34134960-6	2021	The results of Western blotting showed that curcumin also concentration-dependently increased the cellular expressions of caspase-3, caspase-9 and Bax and lowered the expressions of Bcl-2, cyclin B1, CDK1 and beta-catenin along with the downstream proteins cyclin D1 and c-myc in the Wnt/beta-catenin signaling pathway (P < 0.05).	Curcumin	44-52	cyclin D1	Homo sapiens	257-266
34093803-8	2021	In addition, the expressions of Cyclin B1, Cyclin D1, Bcl-2, PARP1 and Survivin were decreased after starch demethylation.	Starch	101-107	cyclin D1	Homo sapiens	43-52
34067020-4	2021	Transcriptomic profiling with RNA-seq indicated the top responses to AS-10 exposure as CDKN1A (P21Cip1), CCND1, and nuclear transcription factor-kappa B (NF-kappaB) complex and the top functions as cell cycle, cell death, and survival without inducing the DNA damage gene signature.	antineoplaston A10	69-74	cyclin D1	Homo sapiens	105-110
34121975-8	2021	Candesartan suppressed tumor cell proliferation and migration by modulating Cyclin D1, MMP3/9, and E-cadherin.	candesartan	0-11	cyclin D1	Homo sapiens	76-85
34159092-6	2021	By western blot assay, we found that devazepide can down-regulate CyclinD1 expression, and up-regulate Bax, PARP1, and Cleaved Caspase-3 expression.	Devazepide	37-47	cyclin D1	Homo sapiens	66-74
34374237-6	2021	Conclusion: At a final concentration of 10~30 mug/ml, betulinic acid can reduce the proliferation of human gastric cancer MGC-803 cells, inhibit cell growth, and down-regulate the expression of CCNB1 and CCND1 to block human gastric cancer MGC-803 cells in the S phase.	betulinic acid	54-68	cyclin D1	Homo sapiens	204-209
34223631-8	2021	In addition, BEZ235 arrested K562/A cells at the G0/G1 phase, and reduced the protein expression levels of CDK4, CDK6 and cyclin D1.	dactolisib	13-19	cyclin D1	Homo sapiens	122-131
34981469-9	2021	The expression levels of all tested genes were altered in all treatment groups compared to the control, with that of WNT1, CTNNB1, TCF, MTOR, AKT1, BIRC5, and CCND1 showing the most robust changes in the combined curcumin/berberine/5-FU treatment.	Curcumin	213-221	cyclin D1	Homo sapiens	159-164
34981469-9	2021	The expression levels of all tested genes were altered in all treatment groups compared to the control, with that of WNT1, CTNNB1, TCF, MTOR, AKT1, BIRC5, and CCND1 showing the most robust changes in the combined curcumin/berberine/5-FU treatment.	Berberine	222-231	cyclin D1	Homo sapiens	159-164
34981469-9	2021	The expression levels of all tested genes were altered in all treatment groups compared to the control, with that of WNT1, CTNNB1, TCF, MTOR, AKT1, BIRC5, and CCND1 showing the most robust changes in the combined curcumin/berberine/5-FU treatment.	Fluorouracil	232-236	cyclin D1	Homo sapiens	159-164
34273265-5	2021	We found that platycodin D had significant anti-proliferative effects on four types of cancer cells, especially the 5637 bladder cancer cell line, and exerted these effects by preventing cell cycle progression from G0/G1 to S phase, down-regulating Ki-67 and cyclin D1 protein expression and up-regulating P21 protein expression.	platycodin D	14-26	cyclin D1	Homo sapiens	259-268
35568265-3	2022	Our results reveal that imipramine inhibits the expression of several cell cycle- and DNA repair-associated proteins including E2F1, CDK1, Cyclin D1, and RAD51.	Imipramine	24-34	cyclin D1	Homo sapiens	139-148
35487445-6	2022	Phthalates changed methylation pattern of the tested genes, decreased expression of P16 and TP53 genes and increased the expression of BCL2 and CCND1.	phthalic acid	0-10	cyclin D1	Homo sapiens	144-149
35561750-8	2022	Molecular markers of hypoxia, induced by CoCl2, were normalized or reduced by MSM, which also inhibited the effect of CoCl2-induced JAK2/STAT5b/Cyclin D1 and PI3K/AKT signaling.	cobaltous chloride	118-123	cyclin D1	Homo sapiens	144-153
35176168-5	2022	WEE1 inhibitor AZD1775 reduced IKK/RELA phosphorylation and the expression of NF-kappaB-dependent pro-survival proteins Cyclin D1 and BCL2.	adavosertib	15-22	cyclin D1	Homo sapiens	120-129
35483142-3	2022	Firstly, citrinin mades L02 cell cycle arrest in G2/M phase by inhibition of cyclin B1, cyclin D1, cyclin-dependent kinases 2 (CDK2), and CDK4 expression.	Citrinin	9-17	cyclin D1	Homo sapiens	88-97
35266250-9	2022	The fucoxanthin effectively inhibited the PI3K/Akt/mTOR cascade along with the expression of TNF-alpha, NF-kappaB, Cox-2, and IL-6 and antiapoptotic genes cyclin D1 and Bcl-2 in the HEC-1A cells.	fucoxanthin	4-15	cyclin D1	Homo sapiens	155-164
35219784-2	2022	The impact of non-ionic surfactant Tween 80 (TW80) on the infectivity of infectious bursal disease virus (IBDV) was studied in BCL1 cells.	Polysorbates	35-43	cyclin D1	Homo sapiens	127-131
35219784-2	2022	The impact of non-ionic surfactant Tween 80 (TW80) on the infectivity of infectious bursal disease virus (IBDV) was studied in BCL1 cells.	Polysorbates	45-49	cyclin D1	Homo sapiens	127-131
35619550-9	2022	MLT+AGP induced cell death by inhibiting beta-catenin expression and its downregulatory signals, Cyclin D1, c-Myc.	andrographolide	4-7	cyclin D1	Homo sapiens	97-106
35220126-9	2022	gamma-Al2O3-5-FU inhibited cell growth in two-dimensional (2D) and three-dimensional (3D) cell culture and increased apoptosis as detected by DAPI stainning via modulation of caspases, BAx, BCl2 and cyclinD1.	gamma-al2o3-5-fu	0-16	cyclin D1	Homo sapiens	199-207
35570522-11	2022	Additionally, the treatment of endometrial cancer with compound 968 downregulated the expression of GLS1 and cyclin D1, and upregulated the expression of P21 and E-cadherin.	compound 968	55-67	cyclin D1	Homo sapiens	109-118
35598400-5	2022	CBD treatment led to G1-phase cell cycle arrest and an increased sub-G1 population (apoptotic cells); it also downregulated protein expression of cyclin D1, cyclin D3, cyclin-dependent kinase 2 (CDK2), CDK4, and CDK6.	Cannabidiol	0-3	cyclin D1	Homo sapiens	146-155
35634368-5	2022	In vitro experiments suggested that CCP significantly inhibited the proliferation of MDA-MB-231 cells, decreased the expressions of cyclin D1 and CDK4 and stocked cells at G0/G1 phase.	ccp	36-39	cyclin D1	Homo sapiens	132-141
35521898-7	2022	Functionally, propofol restrained cell viability, cell cycle entrance, cell proliferation, migration, and invasion of LUAD cells, accompanied by promoted E-cadherin and depressed CyclinD1 and Vimentin.	Propofol	14-22	cyclin D1	Homo sapiens	179-187
35503759-19	2022	We also observed that diverse proteins related to the STAT3 signaling pathway, including c-Myc, Bcl-xL, Mcl-1, cyclin D1 and cyclin D3, were powerfully inhibited by radotinib treatment in MM cells.	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-trifluoromethylphenyl)-3-(4-pyrazin-2-ylpyrimidin-2-ylamino)benzamide	165-174	cyclin D1	Homo sapiens	111-120
35276466-6	2022	Furthermore, both the butyrate-containing supernatant of S2T10D and glucose-deprived cell culture medium supplemented with the same concentration of butyrate found in S2T10D supernatant, induced a pH-independent cancer cell growth inhibition accompanied by downregulation of cyclin D1 at mRNA level.	Butyrates	149-157	cyclin D1	Homo sapiens	275-284
35088889-12	2022	After treatment with 4-OHT, knockdown of ATG4A suppressed proliferation, triggered apoptosis, decreased the expression of Bcl-2, beta-catenin, cyclin D1 and c-myc, and increased the expression of Bax and p-GSK3beta in MCF7/R cells.	4,17 beta-dihydroxy-4-androstene-3-one	21-26	cyclin D1	Homo sapiens	143-152
35378241-4	2022	MiR-182-5p and SMARCA5 were upregulated and DNMT3A, beta-catenin, and Cyclin D1 were downregulated in UC patients, IL-1beta-stimulated Caco-2 cells, and DSS-treated mice.	dss	153-156	cyclin D1	Homo sapiens	70-79
35152538-10	2022	Ethanol also induced activation of the Wnt/TCF-LEF1 pathway and its targets (Bcl-2, Cyclin D1, AXIN2 and Myc).	Ethanol	0-7	cyclin D1	Homo sapiens	84-93
35194944-7	2022	Additionally, DCZ0415 decreased cyclin D1, beta-catenin and T-cell factor 1, leading to the inactivation of the Wnt/beta-catenin pathway.	DCZ0415	14-21	cyclin D1	Homo sapiens	32-41
35406401-6	2022	RESULTS: 5-Aza downregulated cell viability/growth/migration/adhesion by upregulating miR-139-5p, which in turn downregulated ROCK2/cyclin D1/E2F1 and increased p27kip1, resulting in G1/G0 cell accumulation.	Azacitidine	9-14	cyclin D1	Homo sapiens	132-141
35406401-10	2022	CONCLUSION: We demonstrate for the first time that 5-Aza can impair HCC development via upregulation of miR-139-5p, which in turn impairs the ROCK2/cyclin D1/E2F1/cyclin B1 pro-proliferative pathway and the ROCK2/MMP-2 pro-migratory pathway.	Azacitidine	51-56	cyclin D1	Homo sapiens	148-157
35337176-9	2022	Mechanistically, ICG-001 treatment induced apoptosis and led to a downregulation of CBP, c-MYC, and Cyclin D1 in HPV-positive cells, indicating inhibition of Wnt/Beta-Catenin signaling.	ICG 001	17-24	cyclin D1	Homo sapiens	100-109
35326689-11	2022	Moreover, 5-FU/VD3/Met revealed maximal inhibitions of cell cycle inducers (CCND1/CCND3), cell survival (BCL2), and the PI3K/Akt/mTOR molecules alongside the highest expression of cell cycle inhibitors (p21/p27), proapoptotic markers (BAX/cytochrome C/caspase-3), and PTEN in both cell lines.	Fluorouracil	10-14	cyclin D1	Homo sapiens	76-81
35264157-12	2022	Further study showed that metformin blocked the cells in G1 phase by inducing phosphorylated YAP1 and reducing the expression of cyclin D1, CDK6, CDK4 and RB, which enhanced the chemosensitivity of cisplatin and activated the expression of cleaved caspase 3 in TGCTs.	Metformin	26-35	cyclin D1	Homo sapiens	129-138
35264157-12	2022	Further study showed that metformin blocked the cells in G1 phase by inducing phosphorylated YAP1 and reducing the expression of cyclin D1, CDK6, CDK4 and RB, which enhanced the chemosensitivity of cisplatin and activated the expression of cleaved caspase 3 in TGCTs.	Cisplatin	198-207	cyclin D1	Homo sapiens	129-138
35236827-6	2022	In mechanism, INHBA is an important ligand of TGF-beta signaling and metformin blocked the activation of TGF-beta signaling by targeting INHBA, and then down-regulated the activity of PI3K/Akt pathway, leading to the reduction of cyclinD1 and cell cycle arrest.	Metformin	69-78	cyclin D1	Homo sapiens	230-238
35235599-9	2022	BR2-2xPPD treatment induced cell cycle arrest by inhibiting the expression of cyclin D1 and CDK2 genes in EGFR-wild type A549 cells.	br2-2xppd	0-9	cyclin D1	Homo sapiens	78-87
35230971-7	2022	Specifically, FD-895 and pladienolide B significantly downregulates Wnt signaling pathway-associated transcripts (GSK3beta and LRP5) and both transcript and proteins including LEF1, CCND1, LRP6, and pLRP6 at the transcript, total protein, and protein phosphorylation"s levels.	pladienolide	25-37	cyclin D1	Homo sapiens	182-187
35405577-6	2022	The antitumor mechanisms of PT/DOX-MS were possibly due to that the introduction of PT-2385 could effectively inhibit the expression level of HIF-2alpha in hypoxic HCC cells, thereby down-regulating the expression levels of Cyclin D1, VEGF and TGF-alpha.	Platinum	28-30	cyclin D1	Homo sapiens	224-233
35405577-6	2022	The antitumor mechanisms of PT/DOX-MS were possibly due to that the introduction of PT-2385 could effectively inhibit the expression level of HIF-2alpha in hypoxic HCC cells, thereby down-regulating the expression levels of Cyclin D1, VEGF and TGF-alpha.	Doxorubicin	31-34	cyclin D1	Homo sapiens	224-233
35245683-6	2022	Furthermore, Z16-18 could inhibit the interaction between E7 and pRb to block the E7-pRb carcinogenic pathway, resulting in the decreased release of E2F and the cell growth inhibition characterized by the decrease of CDK6 and Cyclin D1.	z16-18	13-19	cyclin D1	Homo sapiens	226-235
35476303-0	2022	Ribonucleotide reductase holoenzyme inhibitor COH29 interacts with deubiquitinase ubiquitin-specific protease 2 and downregulates its substrate protein cyclin D1.	N-(4-(3,4-dihydroxyphenyl)-5-phenylthiazol-2-yl)-3,4-dihydroxybenzamide	46-51	cyclin D1	Homo sapiens	152-161
35476303-8	2022	The results of cellular assays confirmed that the application of COH29 could downregulate the level of cyclin D1 by enhancing its degradation via ubiquitin-proteasome system (UPS), and the modulation effect of COH29 on cyclin D1 is independent of RRM2.	N-(4-(3,4-dihydroxyphenyl)-5-phenylthiazol-2-yl)-3,4-dihydroxybenzamide	65-70	cyclin D1	Homo sapiens	103-112
35476303-8	2022	The results of cellular assays confirmed that the application of COH29 could downregulate the level of cyclin D1 by enhancing its degradation via ubiquitin-proteasome system (UPS), and the modulation effect of COH29 on cyclin D1 is independent of RRM2.	N-(4-(3,4-dihydroxyphenyl)-5-phenylthiazol-2-yl)-3,4-dihydroxybenzamide	65-70	cyclin D1	Homo sapiens	219-228
35476303-8	2022	The results of cellular assays confirmed that the application of COH29 could downregulate the level of cyclin D1 by enhancing its degradation via ubiquitin-proteasome system (UPS), and the modulation effect of COH29 on cyclin D1 is independent of RRM2.	N-(4-(3,4-dihydroxyphenyl)-5-phenylthiazol-2-yl)-3,4-dihydroxybenzamide	210-215	cyclin D1	Homo sapiens	103-112
35476303-8	2022	The results of cellular assays confirmed that the application of COH29 could downregulate the level of cyclin D1 by enhancing its degradation via ubiquitin-proteasome system (UPS), and the modulation effect of COH29 on cyclin D1 is independent of RRM2.	N-(4-(3,4-dihydroxyphenyl)-5-phenylthiazol-2-yl)-3,4-dihydroxybenzamide	210-215	cyclin D1	Homo sapiens	219-228
35476303-9	2022	Since cyclin D1 acts as an oncogenic driver in human cancer, our findings suggest that USP2 might be a promising therapeutic target for cyclin D1-addicted cancers, and COH29 could serve as a starting compound for high selectivity inhibitor development against USP2.	N-(4-(3,4-dihydroxyphenyl)-5-phenylthiazol-2-yl)-3,4-dihydroxybenzamide	168-173	cyclin D1	Homo sapiens	6-15
35266008-11	2022	Cyclopamine treatment was found to arrest 786-O cells in the G2/M phase and decreased the expression levels of GLI1, BCL2, VEGFA and CCND1.	cyclopamine	0-11	cyclin D1	Homo sapiens	133-138
35266008-12	2022	RU-SKI43 inhibited cell migration and decreased the expression levels of BCL2, MYC and CCND1 in ACHN cells.	Ethanone, 1-[4-[(4-chloro-3-Methylphenoxy)Methyl]-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-2-[(3-Methoxypropyl)aMino]-	0-8	cyclin D1	Homo sapiens	87-92
35528169-11	2022	Furthermore, baicalin inhibited the levels of Ras, p-ERK, and cyclin D1 induced by Abeta, and this effect could be reversed by the MEK activator.	baicalin	13-21	cyclin D1	Homo sapiens	62-71
35607957-5	2022	Herein, we demonstrated that 17beta-estradiol enhances the proliferative ability of gADSCs, indicated by the increased cell number and cell viability, accompanied by up-regulated expressions of cyclin D1 and PCNA.	Estradiol	29-45	cyclin D1	Homo sapiens	194-203
35563105-8	2022	Similarly, resveratrol-blocked TME-induced p65-NF-kB and its promoted gene markers linked to proliferation (cyclin D1), invasion (focal adhesion kinase, FAK), or apoptosis (caspase-3), were largely abrogated by anti-beta1-integrin or RGD peptide, suggesting that beta1-integrin is a potential transmission pathway for resveratrol/integrin down-stream signaling in CRC cells.	Resveratrol	11-22	cyclin D1	Homo sapiens	108-117
35517785-8	2022	Reduced cyclin D1 protein levels were consistent with G0/G1 phase arrest, especially when resulting from the combination of ITZ with rapamycin.	Itraconazole	124-127	cyclin D1	Homo sapiens	8-17
35517785-8	2022	Reduced cyclin D1 protein levels were consistent with G0/G1 phase arrest, especially when resulting from the combination of ITZ with rapamycin.	Sirolimus	133-142	cyclin D1	Homo sapiens	8-17
35531132-8	2022	The expression of XIAP, cyclin D1, and Bcl-2 genes and proteins in the groups treated with ALT, Cis, and ZnONPs as a single agent, double and triple combination were significantly reduced compared to the control, while Bax was generally shown an increase.	alantolactone	91-94	cyclin D1	Homo sapiens	24-33
35531132-8	2022	The expression of XIAP, cyclin D1, and Bcl-2 genes and proteins in the groups treated with ALT, Cis, and ZnONPs as a single agent, double and triple combination were significantly reduced compared to the control, while Bax was generally shown an increase.	cis, and znonps	96-111	cyclin D1	Homo sapiens	24-33
35343565-4	2022	In non-transformed cells, p21 activates RB in G2 by inhibiting Cyclin D1-CDK2/CDK4.	Rubidium	40-42	cyclin D1	Homo sapiens	63-72
35444864-13	2022	Restoration of miR-34a-5p decreased cell proliferation and migration, leading to a G1 cell cycle arrest and down-regulation of CDK4/6, cyclin D1, MMP2, MMP9.	mir-34a-5p	15-25	cyclin D1	Homo sapiens	135-144
35444456-9	2022	The results of immunohistochemical staining from clinical samples further confirmed that high expression of CCND1 and FADD was frequently detected in luminal B and high-grade breast cancer with shorter metastasis-free survival times (P < 0.05).	Phenobarbital	150-157	cyclin D1	Homo sapiens	108-113
35396910-13	2022	In conclusion, ANRIL indirectly up-regulates CCND1 expression by targeting miR-98-5p to promote ASMC proliferation, migration and ECM deposition, thus facilitating the pathogenesis of asthma.	asmc	96-100	cyclin D1	Homo sapiens	45-50
35458590-7	2022	RESULTS: The combination of EPO and TAM suppressed the VEGF level, VEGF gene expression and Cyclin D1 signaling pathways, arrested the cell cycle, and induced the apoptotic signaling pathways by increasing the Bax/Bcl-2 ratio and caspase 3 activity; this revealed significant anti-tumor activity.	evening primrose oil	28-31	cyclin D1	Homo sapiens	92-101
35458590-7	2022	RESULTS: The combination of EPO and TAM suppressed the VEGF level, VEGF gene expression and Cyclin D1 signaling pathways, arrested the cell cycle, and induced the apoptotic signaling pathways by increasing the Bax/Bcl-2 ratio and caspase 3 activity; this revealed significant anti-tumor activity.	tam	36-39	cyclin D1	Homo sapiens	92-101
35459982-2	2022	Increased CCND1 copy number (CN) in breast cancer (BC) is associated with high histopathological grade, high proliferation, and Luminal B subtype.	Phenobarbital	128-135	cyclin D1	Homo sapiens	10-15
35459982-8	2022	CCND1 CN (>= 6) was seen in all molecular subtypes, most frequently in Luminal B (HER2-) (20/126; 16%).	Phenobarbital	71-78	cyclin D1	Homo sapiens	0-5
35441158-7	2022	Multiple alterations in E2-mediated cell cycle control were identified in the endocrine-resistant cell lines including increased expression of MYC, cyclin A1, cyclin D1, cyclin-dependent kinase 1 (CDK1), CDK2, and hyperphosphorylated retinoblastoma protein (ppRb), whereas p21 and p27 were reduced.	Estradiol	24-26	cyclin D1	Homo sapiens	159-168
35159107-6	2022	In this study we show that the combination of low concentrations of panobinostat and Tegavivint have significant in vitro and in vivo anti-MM effects including in the context of proteasome inhibitor resistance, by targeting both aerobic glycolysis and mitochondrial respiration and the down-regulation of down-stream beta-catenin targets including myc, cyclinD1, and cyclinD2.	Tegatrabetan	85-95	cyclin D1	Homo sapiens	353-361
35216636-0	2022	LncRNA CASC15 upregulates cyclin D1 by downregulating miR-365 in laryngeal squamous cell carcinoma to promote cell proliferation.	mir-365	54-61	cyclin D1	Homo sapiens	26-35
35216636-9	2022	Overexpression of miR-365 did not affect the expression of CASC15 but downregulated cyclin D1.	mir-365	18-25	cyclin D1	Homo sapiens	84-93
35216636-13	2022	CONCLUSION: Therefore, CASC15 upregulates cyclin D1 by downregulating miR-365 in LSCC to promote cell proliferation.	mir-365	70-77	cyclin D1	Homo sapiens	42-51
35088780-10	2022	An in vivo study further confirmed the regulatory effect of NBT on CELF6 and cyclin D1 levels in a HeLa xenograft model.	neobractatin	60-63	cyclin D1	Homo sapiens	77-86
35237605-9	2022	Doxycycline suppresses cell cyclin D1 (CCND1) and c-Myc which play crucial roles in proliferation.	Doxycycline	0-11	cyclin D1	Homo sapiens	28-37
35237605-9	2022	Doxycycline suppresses cell cyclin D1 (CCND1) and c-Myc which play crucial roles in proliferation.	Doxycycline	0-11	cyclin D1	Homo sapiens	39-44
35148777-13	2022	Furthermore, canagliflozin inhibited G1/S phase transition and cyclin D1, cyclin D3, cyclin E1, cyclin E2, and E2F1 expression levels in thyroid cancer cell.	Canagliflozin	13-26	cyclin D1	Homo sapiens	63-72
35159107-6	2022	In this study we show that the combination of low concentrations of panobinostat and Tegavivint have significant in vitro and in vivo anti-MM effects including in the context of proteasome inhibitor resistance, by targeting both aerobic glycolysis and mitochondrial respiration and the down-regulation of down-stream beta-catenin targets including myc, cyclinD1, and cyclinD2.	Panobinostat	68-80	cyclin D1	Homo sapiens	353-361
35120552-13	2022	Additionally, the phosphorylation of AKT and expression of Cyclin D1, which were closely related with cellular growth, were distinctly lessened after treating with imatinib.	Imatinib Mesylate	164-172	cyclin D1	Homo sapiens	59-68
35048155-8	2022	In summary, our data demonstrated that 4E-BP1 participated in PTC-induced cell cycle arrest in extravillous trophoblast cells by regulating cyclin D1.	prothioconazole	62-65	cyclin D1	Homo sapiens	140-149
34747319-6	2022	Also, GA treatment significantly decreased the Bax/Bcl2 protein ratio and the expression of Cyclin D1, CDK2, CDK4, MMP-9, N-cadherin, and vimentin in SW620 and HT29 cells.	Glycyrrhizic Acid	6-8	cyclin D1	Homo sapiens	92-101
35163589-7	2022	Regorafenib suppressed proliferation in HuH-7 cell and induced G0/G1 cell cycle arrest and cyclin D1 downregulation in regorafenib-sensitive cells.	regorafenib	0-11	cyclin D1	Homo sapiens	91-100
35163589-7	2022	Regorafenib suppressed proliferation in HuH-7 cell and induced G0/G1 cell cycle arrest and cyclin D1 downregulation in regorafenib-sensitive cells.	regorafenib	119-130	cyclin D1	Homo sapiens	91-100
35163589-9	2022	Regorafenib suppresses cell proliferation and tumor growth in HCC by decreasing cyclin D1 via alterations in intracellular and exosomal miRNAs in HCC.	regorafenib	0-11	cyclin D1	Homo sapiens	80-89
35049931-8	2022	Moreover, NF-kappaB inhibitor PDTC could strengthen the effects of FGFC1 on the expression of CDK4, Cyclin D1, cleaved-PARP-1, and cleaved-caspase-3 proteins, suggesting that the NF-kappaB pathway plays a major role in FGFC1-induced cell cycle arrest and apoptosis.	prolinedithiocarbamate	30-34	cyclin D1	Homo sapiens	100-109
35178295-14	2022	The expression of DIDO may be regulated by H3K4me3 and the inhibition of DIDO may lead to the down-regulation of CDK6 and CCND1.	3,4-dihydroxybenzohydroxamic acid	18-22	cyclin D1	Homo sapiens	122-127
35178295-14	2022	The expression of DIDO may be regulated by H3K4me3 and the inhibition of DIDO may lead to the down-regulation of CDK6 and CCND1.	3,4-dihydroxybenzohydroxamic acid	73-77	cyclin D1	Homo sapiens	122-127
34974760-2	2022	Meanwhile, compared with normal L-02 cells, arsenic-transformed malignant cells, L-02-As displayed more ROS and significantly higher Cyclin D1 expression as well as aerobic glycolysis.	Arsenic	44-51	cyclin D1	Homo sapiens	133-142
35096835-9	2021	Furthermore, we found that butyrate augmented the previously described effects of HDAC6 inhibitors on CCA cell proliferation and migration by reducing the expression of CD44, cyclin D1, PCNA, Zeb1, and Vimentin.	Butyrates	27-35	cyclin D1	Homo sapiens	175-184
35070983-14	2021	Furthermore, quercetin combined with cisplatin downregulated the expression of EGFR, MYC, CCND1, and ERBB2 proteins and upregulated CASP8 expression in HeLa and SiHa cells.	Quercetin	13-22	cyclin D1	Homo sapiens	90-95
35070983-14	2021	Furthermore, quercetin combined with cisplatin downregulated the expression of EGFR, MYC, CCND1, and ERBB2 proteins and upregulated CASP8 expression in HeLa and SiHa cells.	Cisplatin	37-46	cyclin D1	Homo sapiens	90-95
34974760-4	2022	In addition, scavenging of ROS by NAC resulted in a decreased expression of phospho-Akt, HK2 and Cyclin D1, and attenuates the ability of anchorage-independent growth ofL-02-As cells, suggested that ROS mediated the Akt activation in L-02-As cells.	Reactive Oxygen Species	27-30	cyclin D1	Homo sapiens	97-106
34974760-3	2022	Moreover, Akt activation is followed by the upregulation of Cyclin D1 and HK2 expression in L-02-As cells, since inhibition of Akt activity by Ly294002 attenuated the colony formation in soft agar and decreased the levels of Cyclin D1 and HK2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	cyclin D1	Homo sapiens	60-69
34974760-4	2022	In addition, scavenging of ROS by NAC resulted in a decreased expression of phospho-Akt, HK2 and Cyclin D1, and attenuates the ability of anchorage-independent growth ofL-02-As cells, suggested that ROS mediated the Akt activation in L-02-As cells.	Reactive Oxygen Species	199-202	cyclin D1	Homo sapiens	97-106
34974760-3	2022	Moreover, Akt activation is followed by the upregulation of Cyclin D1 and HK2 expression in L-02-As cells, since inhibition of Akt activity by Ly294002 attenuated the colony formation in soft agar and decreased the levels of Cyclin D1 and HK2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	cyclin D1	Homo sapiens	225-234
34974760-3	2022	Moreover, Akt activation is followed by the upregulation of Cyclin D1 and HK2 expression in L-02-As cells, since inhibition of Akt activity by Ly294002 attenuated the colony formation in soft agar and decreased the levels of Cyclin D1 and HK2.	Agar	192-196	cyclin D1	Homo sapiens	60-69
35180914-8	2022	Additionally, the anti-cancer function of this novel liposomal nanoparticle-modified valeric acid was found to be related to STAT3/Cyclin D1 pathway.	n-pentanoic acid	85-97	cyclin D1	Homo sapiens	131-140
35098809-9	2022	Another subgroup assessment of OS established that MM patients with CCND1 overexpression in the bortezomib group had longer survival time (HR = 0.30, 95% CI: 0.11-0.82), whereas, those overexpressing CCND1 in the conventional chemotherapy group had poor prognosis (HR = 2.19, 95% CI: 1.18-4.08).	Bortezomib	96-106	cyclin D1	Homo sapiens	68-73
35098809-11	2022	Conclusion: The result of this meta-analysis suggested that CCND1 overexpression might be a predictive biomarker for MM patients when treated with bortezomib, receiving ASCT, or in relapsed and refractory period.	Bortezomib	147-157	cyclin D1	Homo sapiens	60-65
3257163-3	1988	In BCL1 cells activated by LPS for 24 h and recultured with a pharmacological concentration of the synthetic glucocorticoid triamcinolone acetonide (TA, 10(-6) M) for 6 h, lipid lateral diffusion increased to 3.5 x 10(-9) cm2s-1.	Triamcinolone Acetonide	124-147	cyclin D1	Homo sapiens	3-7
3257163-7	1988	Plasma membrane cholesterol and phospholipid content, analyzed at 0 and 24 h, indicated that LPS activation was associated with a 7% increase in the cholesterol:phospholipid ratio in BCL1 membranes and that glucocorticoid treatment of these LPS-activated cells for 6 h decreased the membrane cholesterol:phospholipid ratio perhaps through inhibition of de novo cholesterol synthesis.	Cholesterol	149-160	cyclin D1	Homo sapiens	183-187
3257163-7	1988	Plasma membrane cholesterol and phospholipid content, analyzed at 0 and 24 h, indicated that LPS activation was associated with a 7% increase in the cholesterol:phospholipid ratio in BCL1 membranes and that glucocorticoid treatment of these LPS-activated cells for 6 h decreased the membrane cholesterol:phospholipid ratio perhaps through inhibition of de novo cholesterol synthesis.	Phospholipids	161-173	cyclin D1	Homo sapiens	183-187
3257163-7	1988	Plasma membrane cholesterol and phospholipid content, analyzed at 0 and 24 h, indicated that LPS activation was associated with a 7% increase in the cholesterol:phospholipid ratio in BCL1 membranes and that glucocorticoid treatment of these LPS-activated cells for 6 h decreased the membrane cholesterol:phospholipid ratio perhaps through inhibition of de novo cholesterol synthesis.	Cholesterol	149-160	cyclin D1	Homo sapiens	183-187
3257163-7	1988	Plasma membrane cholesterol and phospholipid content, analyzed at 0 and 24 h, indicated that LPS activation was associated with a 7% increase in the cholesterol:phospholipid ratio in BCL1 membranes and that glucocorticoid treatment of these LPS-activated cells for 6 h decreased the membrane cholesterol:phospholipid ratio perhaps through inhibition of de novo cholesterol synthesis.	Phospholipids	161-173	cyclin D1	Homo sapiens	183-187
3257163-7	1988	Plasma membrane cholesterol and phospholipid content, analyzed at 0 and 24 h, indicated that LPS activation was associated with a 7% increase in the cholesterol:phospholipid ratio in BCL1 membranes and that glucocorticoid treatment of these LPS-activated cells for 6 h decreased the membrane cholesterol:phospholipid ratio perhaps through inhibition of de novo cholesterol synthesis.	Cholesterol	149-160	cyclin D1	Homo sapiens	183-187
33865831-8	2021	Accordingly, co-treatment with DSF and Cu downregulated the expression of Cyclin D1 and Cyclin A2, whereas this combination upregulated the level of P21 and P27.	Copper	39-41	cyclin D1	Homo sapiens	74-83
3871335-11	1985	Partially deproteinized chromatin from lipopolysaccharide-stimulated BCL1 cells demonstrated a different pattern of receptor binding, i.e., receptor binding was significantly greater to chromatin previously extracted with 6-8 M guanidine hydrochloride.	Guanidine	228-251	cyclin D1	Homo sapiens	69-73
6744240-7	1984	The BCL1 leukemia may be a useful animal model to provide insights into the biochemical basis for the adverse reactions experienced by some Hodgkin"s disease patients when they are treated with anti-inflammatory agents such as indomethacin.	Indomethacin	227-239	cyclin D1	Homo sapiens	4-8
33910730-3	2021	OGC treatment (100 mug/mL) significantly increased the proliferation of TMSCs, which could be attributed to cyclin D1 up-regulation in the G1 phase of the cell cycle.	ogc	0-3	cyclin D1	Homo sapiens	108-117
33621883-5	2021	Low concentrations of BPAF markedly increased the expression of G protein-coupled estrogen receptor (GPER1), c-Myc, CyclinD1 and c-Fos proteins, and enhanced phosphorylation of extracellular signal-regulated kinase (Erk) and protein kinase B (Akt) in SKBR-3 cells.	4,4'-hexafluorisopropylidene diphenol	22-26	cyclin D1	Homo sapiens	116-124
33895117-11	2021	kCREB had no effect on Cyclin D1 expression, but did prevent PDGF-induced Cyclin D1 nuclear translocation.	kcreb	0-5	cyclin D1	Homo sapiens	74-83
33831397-6	2021	Mechanistically, HHT and quizartinib cooperatively inhibit FLT3-AKT and its downstream targets GSK3beta, c-Myc, and cyclin D1, cooperatively up-regulate the pro-apoptosis proteins Bim and Bax, and down-regulate the anti-apoptosis protein Mcl1.	quizartinib	25-36	cyclin D1	Homo sapiens	116-125
33968189-14	2021	In addition, miR-219a-2-3p was confirmed to target HPSE and inhibit cell proliferation, which was associated with cyclin D1 suppression-mediated cell cycle arrest.	mir-219a-2-3p	13-26	cyclin D1	Homo sapiens	114-123
31282137-0	2021	Efficacy of trastuzumab combined with cisplatin and docetaxel on gastric cardia carcinoma and its influence on HER2 and cyclin D1 expressions.	Cisplatin	38-47	cyclin D1	Homo sapiens	120-129
31282137-0	2021	Efficacy of trastuzumab combined with cisplatin and docetaxel on gastric cardia carcinoma and its influence on HER2 and cyclin D1 expressions.	Docetaxel	52-61	cyclin D1	Homo sapiens	120-129
34058070-9	2021	Finally, a c-MYC gain, along with a loss of CCND1 and FGFR3, were detected in a patient progressing on a first-line treatment with crizotinib.	Crizotinib	131-141	cyclin D1	Homo sapiens	44-49
34056642-8	2021	The results suggest that delta-tocotrienol induces cell cycle arrest in CNE1 cells via the p16/CDK4/cyclin D1 signaling pathway.	tocotrienol, delta	25-42	cyclin D1	Homo sapiens	100-109
33784509-8	2021	Furthermore, rapid reduction of cyclin D1 upon DNA damage was attributed to proteasomal degradation, as evidenced by data showing that proteasomal inhibition by MG132 blocked cyclin D1 reduction while cycloheximide facilitated it.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	161-166	cyclin D1	Homo sapiens	32-41
33784509-8	2021	Furthermore, rapid reduction of cyclin D1 upon DNA damage was attributed to proteasomal degradation, as evidenced by data showing that proteasomal inhibition by MG132 blocked cyclin D1 reduction while cycloheximide facilitated it.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	161-166	cyclin D1	Homo sapiens	175-184
33784509-8	2021	Furthermore, rapid reduction of cyclin D1 upon DNA damage was attributed to proteasomal degradation, as evidenced by data showing that proteasomal inhibition by MG132 blocked cyclin D1 reduction while cycloheximide facilitated it.	Cycloheximide	201-214	cyclin D1	Homo sapiens	32-41
34029286-9	2021	Furthermore, high glucose also caused SH-SY5Y cells arrest in G2 phase and apoptosis, accompanied by decreasing cyclin D1 and E2, and upregulating Bax and cleaved caspase-3.	Glucose	18-25	cyclin D1	Homo sapiens	112-121
33982124-0	2021	let-7c-5p regulates CyclinD1 in fluoride-mediated osteoblast proliferation and activation.	Fluorides	32-40	cyclin D1	Homo sapiens	20-28
33982124-5	2021	Based on our previous miRNA sequencing results and bioinformatics analysis, we investigated the function of the miRNA let-7c-5p to regulate CyclinD1 in fluoride-induced osteoblast proliferation and activation.	Fluorides	152-160	cyclin D1	Homo sapiens	140-148
33982124-9	2021	We verified in vitro that let-7c-5p participates in the fluoride-induced proliferation and activation of human osteoblasts by directly targeting CyclinD1.	Fluorides	56-64	cyclin D1	Homo sapiens	145-153
33982124-11	2021	This study demonstrated the participation of let-7c-5p in fluoride-induced proliferation and activation of human osteoblasts by regulation of CyclinD1 expression at the post-transcriptional and transcriptional levels.	Fluorides	58-66	cyclin D1	Homo sapiens	142-150
33524509-13	2021	In addition, CESTG arrested cell cycle in the G1/S phase, correlating with decreased levels of cyclin D1/B1, CDK 4 and 6.	cestg	13-18	cyclin D1	Homo sapiens	95-107
33964908-12	2021	Furthermore, PBMF treatment notably upregulated the mRNA expression levels of GSK-3beta, E-cadherin, Bax, Caspase-3, and Caspase-9 but substantially downregulated those of beta-catenin, N-cadherin, MMP-2, MMP-9, Snail, and Cyclin D1 in tumor tissues.	pbmf	13-17	cyclin D1	Homo sapiens	223-232
33961012-9	2021	In SNU-449 cells, dasatinib promoted apoptosis and the cleavage of caspase-3 and caspase-7, induced cell cycle arrest in the G1 phase, and inhibited the expression of Cyclin-dependent kinase (CDK4)/6/CyclinD1 complex.	Dasatinib	18-27	cyclin D1	Homo sapiens	200-208
34026596-8	2021	Similar patterns of beta-elemene-modulated cyclinD1, c-Myc, COX2, MMP2, MMP9, VEGF, PTEN and Notch1 expression were detected in NSCLC cells.	beta-elemene	20-32	cyclin D1	Homo sapiens	43-51
33964282-5	2021	In this study, we identified a novel Hh pathway inhibitor, pseudolaric acid B (PAB), which significantly inhibited the expression of Gli1 and its transcriptional target genes, such as cyclin D1 and N-myc, thus inhibiting the proliferation of DAOY and Ptch1+/- primary MB cells.	pseudolaric acid B	59-77	cyclin D1	Homo sapiens	184-193
33964282-5	2021	In this study, we identified a novel Hh pathway inhibitor, pseudolaric acid B (PAB), which significantly inhibited the expression of Gli1 and its transcriptional target genes, such as cyclin D1 and N-myc, thus inhibiting the proliferation of DAOY and Ptch1+/- primary MB cells.	pseudolaric acid B	79-82	cyclin D1	Homo sapiens	184-193
34025442-8	2021	Results: In the initial small molecular inhibitor screening in KIT-independent GIST62, we found that bortezomib-mediated inhibition of the ubiquitin-proteasome machinery showed anti-proliferative effects of KIT-independent GIST cells via downregulation of cyclin D1 and induction of p53 and p21.	Bortezomib	101-111	cyclin D1	Homo sapiens	256-265
34025442-9	2021	Treatment with proteasome inhibitor, bortezomib, led to downregulation of cyclin D1 and YAP/TAZ and an increase in the cleaved PARP expression in three KIT-independent GIST cell lines (GIST48B, GIST54, and GIST226).	Bortezomib	37-47	cyclin D1	Homo sapiens	74-83
33873145-9	2021	Tacrolimus induced G1/S phase arrest and significantly downregulated the expression of cyclinD1, cyclinE1, and c-Myc.	Tacrolimus	0-10	cyclin D1	Homo sapiens	87-95
33952469-0	2021	MiR-3663-3p Inhibits the Progression of Gastric Cancer Through the CCND1 Pathway.	mir-3663-3p	0-11	cyclin D1	Homo sapiens	67-72
33325633-5	2021	Furthermore, berberine suppressed the activation of the EGFR and ErbB2 downstream targets cyclin D1, MMPs, and VEGF by down-regulating the EGFR-ErbB2/PI3K/Akt signaling pathway.	Berberine	13-22	cyclin D1	Homo sapiens	90-99
32757998-8	2021	Association of the extract with cisplatin enhanced the latter"s antiproliferative effect, arrested the cell cycle at the S phase by CDK2 modulation, and reduced the number of anti-cyclin D1-stained HepG2 cells.	Cisplatin	32-41	cyclin D1	Homo sapiens	180-189
33350292-0	2021	Metformin promotes apoptosis in primary breast cancer cells by downregulation of cyclin D1 and upregulation of P53 through an AMPK-alpha independent mechanism.	Metformin	0-9	cyclin D1	Homo sapiens	81-90
33350292-1	2021	AIM: In the present study we aimed to figure out the effect of metformin on the expression of AMPK-alpha, cyclin D1 and Tp53, and apoptosis in primary breast cancer cells (PBCCs).	Metformin	63-72	cyclin D1	Homo sapiens	106-115
33350292-7	2021	PBCCs treated with 25 mM metformin had lower cyclin D1 expression compared with non-treated cells, however, the difference was not statistically significant.	Metformin	25-34	cyclin D1	Homo sapiens	45-54
33350292-10	2021	CONCLUSION: Metformin can modulate cyclin D1 and p53 expression through AMPK-alpha independent mechanism in breast cancer cells, leading to cell proliferation inhibition and apoptosis induction.	Metformin	12-21	cyclin D1	Homo sapiens	35-44
33905578-7	2021	Dex also prevented MPP+ induced cell arrest by increasing G1 phase cells, decreasing S phase cells, and decreasing the expression of cyclinD1 and Cdk4.	Dexmedetomidine	0-3	cyclin D1	Homo sapiens	133-141
33995632-9	2021	Treatment with lenvatinib decreased the expression of MMP-2, CEMIP, CDK2, CDK4 and cyclin D1, and increased the expression of cleaved caspase-9, which was mediated by the inactivation of the PI3K/AKT pathway in vitro.	lenvatinib	15-25	cyclin D1	Homo sapiens	83-92
33953676-6	2021	The results showed that astragalin significantly inhibited the proliferation and diffusion of HCT116 cells by induced apoptosis (by modulation of Bax, Bcl-2, P53, caspase-3, caspase 6, caspase 7, caspase 8, caspase 9 protein express) and cell cycle arrest (by modulation of Cyclin D1, Cyclin E, P21, P27, CDK2, CDK4 protein express).	astragalin	24-34	cyclin D1	Homo sapiens	274-283
33959188-7	2021	The results demonstrated that quercetin, ephedrine, trigonelline, crocetin, and beta-sitosterol were major effective compounds of LPD responsible for the CG treatment by inhibiting the activation of the JAK 2-STAT 3 signaling pathway to reduce the expressions of cyclin D1 and Bcl-2 proteins.	Quercetin	30-39	cyclin D1	Homo sapiens	263-272
33959188-7	2021	The results demonstrated that quercetin, ephedrine, trigonelline, crocetin, and beta-sitosterol were major effective compounds of LPD responsible for the CG treatment by inhibiting the activation of the JAK 2-STAT 3 signaling pathway to reduce the expressions of cyclin D1 and Bcl-2 proteins.	Ephedrine	41-50	cyclin D1	Homo sapiens	263-272
33959188-7	2021	The results demonstrated that quercetin, ephedrine, trigonelline, crocetin, and beta-sitosterol were major effective compounds of LPD responsible for the CG treatment by inhibiting the activation of the JAK 2-STAT 3 signaling pathway to reduce the expressions of cyclin D1 and Bcl-2 proteins.	trigonelline	52-64	cyclin D1	Homo sapiens	263-272
33938344-0	2021	LncRNA ENSG00000254615 Modulates Proliferation and 5-FU Resistance by Regulating p21 and Cyclin D1 in Colorectal Cancer.	Fluorouracil	51-55	cyclin D1	Homo sapiens	89-98
33512038-4	2021	SBT-A treatment caused cell cycle arrest and decreased the expression of cyclin B1, cyclin D1, p-Cdc2, and p-Cdc25C.	scutebarbatine A	0-5	cyclin D1	Homo sapiens	84-93
33907248-8	2021	EGCG also decreased expression of substrate oncoproteins for PIN1 (including cyclin D1, NF-kappaB p65, c-MYC, and AKT) and 67 kDa laminin receptor (67LR) in the bone marrow cells.	epigallocatechin gallate	0-4	cyclin D1	Homo sapiens	77-86
34056302-8	2021	Consistently, the expressions of MMP-2, Vimentin, CyclinD1, and p-p38 were also decreased after BIRB796 treatment.	doramapimod	96-103	cyclin D1	Homo sapiens	50-58
33873145-10	2021	These results suggest that tacrolimus induces G1/S phase arrest via inhibition of cyclinD1, cyclinE1, and c-Myc expression and retards oral cell carcinogenesis in vitro and in vivo.	Tacrolimus	27-37	cyclin D1	Homo sapiens	82-90
33582643-6	2021	Low-concentration TCBPA also upregulated the expression of GPER, CyclinD1, c-Myc, and c-Fos proteins, as well as increased the phosphorylation of extracellular signal-regulated-kinase 1/2 (Erk1/2) and protein kinase B (Akt).	tetrachlorodian	18-23	cyclin D1	Homo sapiens	65-73
33917267-10	2021	A treatment with the small molecule 5"-nitroindirubin-monoxime (INO) leads to inhibition of cyclin D1 and thus inhibition of proliferation.	5"-nitroindirubin-monoxime	36-62	cyclin D1	Homo sapiens	92-101
33912552-3	2021	Polydatin efficiently inhibited cervical cancer cell proliferation by regulating cell cycle-related proteins including p21, p27, CDK2, CDK4, Cyclin D1, and Cyclin E1.	polydatin	0-9	cyclin D1	Homo sapiens	141-150
33883905-8	2021	Calycosin downregulated the cell cycle proteins cyclin-dependent kinase 2 (CDK2), CDK4, CDK6, cyclin D1, and cyclin E; upregulated p21 and p27; and arrested cells in the G0/G1 phase.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	cyclin D1	Homo sapiens	94-103
33917267-10	2021	A treatment with the small molecule 5"-nitroindirubin-monoxime (INO) leads to inhibition of cyclin D1 and thus inhibition of proliferation.	Inosine	64-67	cyclin D1	Homo sapiens	92-101
33839437-4	2021	The cD1 status (gene amplified/nonamplified) was determined on formalin-fixed paraffin-embedded tumor tissue sections by chromogenic in situ hybridization.	Formaldehyde	63-71	cyclin D1	Homo sapiens	4-7
33959188-7	2021	The results demonstrated that quercetin, ephedrine, trigonelline, crocetin, and beta-sitosterol were major effective compounds of LPD responsible for the CG treatment by inhibiting the activation of the JAK 2-STAT 3 signaling pathway to reduce the expressions of cyclin D1 and Bcl-2 proteins.	crocetin	66-74	cyclin D1	Homo sapiens	263-272
33959188-7	2021	The results demonstrated that quercetin, ephedrine, trigonelline, crocetin, and beta-sitosterol were major effective compounds of LPD responsible for the CG treatment by inhibiting the activation of the JAK 2-STAT 3 signaling pathway to reduce the expressions of cyclin D1 and Bcl-2 proteins.	gamma-sitosterol	80-95	cyclin D1	Homo sapiens	263-272
33839437-4	2021	The cD1 status (gene amplified/nonamplified) was determined on formalin-fixed paraffin-embedded tumor tissue sections by chromogenic in situ hybridization.	Paraffin	78-86	cyclin D1	Homo sapiens	4-7
33839437-12	2021	The role of cyclin D1 as potential parameter of response to tamoxifen was not as pronounced.	Tamoxifen	60-69	cyclin D1	Homo sapiens	12-21
33537802-8	2021	Treatment of U251 cells with PSH induced the upregulation of p21 and p27, and the downregulation cyclin D1 and S-phase kinase associated protein 2 protein expression levels, which induced cell cycle arrest at the G1 phase.	paris saponin H	29-32	cyclin D1	Homo sapiens	97-106
33927474-7	2021	In addition, low-concentration DIO could significantly increase the expression of Ki67, proliferating cell nuclear antigen (PCNA), osteopontin (OPN), and osteocalcin (BGP), promote osteoblast differentiation, and suppress the expression of beta-catenin, Runx2 and cyclinD1.	Diosgenin	31-34	cyclin D1	Homo sapiens	264-272
33460806-4	2021	We found that low concentrations of fluoxetine upregulated the expression of GPR30, ERalpha, CyclinD1, and C-MYC proteins, as well as elevated the phosphorylation of ERK and AKT.	Fluoxetine	36-46	cyclin D1	Homo sapiens	93-101
33275817-6	2021	We showed that both tamoxifen and ISA-2011B exert their on-target effects on prostate cancer cells by targeting cyclin D1 and PIP5K1alpha/AKT network and the interlinked estrogen signaling.	Tamoxifen	20-29	cyclin D1	Homo sapiens	112-121
33275817-6	2021	We showed that both tamoxifen and ISA-2011B exert their on-target effects on prostate cancer cells by targeting cyclin D1 and PIP5K1alpha/AKT network and the interlinked estrogen signaling.	ISA-2011B	34-43	cyclin D1	Homo sapiens	112-121
33649853-11	2021	Furthermore, lycorine significantly downregulated the protein expression levels of cyclin D1 and cyclin E1, but significantly increased p21 and Smad4 protein expression levels in HCT116 and LoVo cells compared with the control group.	lycorine	13-21	cyclin D1	Homo sapiens	83-92
33732382-10	2021	Western blotting results also revealed the upregulation of p53 acetylation and p21, as well as the downregulation of Bcl-2 and cyclin D1 in cells treated with cambinol.	cambinol	159-167	cyclin D1	Homo sapiens	127-136
33795755-7	2021	Proliferative marker, cyclin D1 and Ki67 were found to be upregulated upon ZEA treatment.	Zearalenone	75-78	cyclin D1	Homo sapiens	22-31
33131875-5	2021	We demonstrated a significant reduction in the expression of p21 with a remarkable increase in the expression of cyclin D1 that correlated with increased methylation of CpG dinucleotides in p21 proximal promoter, while cyclin D1 promoter remained unmethylated.	cytidylyl-3'-5'-guanosine	169-186	cyclin D1	Homo sapiens	113-122
33131875-8	2021	Furthermore, AFB1 induced the expression of EZH2 analogue protein E(z), cyclin D1 analogue cyclin D and decreased the expression of p21 analogue Dacapo in Drosophila melanogaster.	Aflatoxin B1	13-17	cyclin D1	Homo sapiens	72-81
33759321-7	2021	SRA exhibited significant downregulation of cyclins including CDK2, CDK4, and Cyclin D1 responsible for cell-cycle regulation.	syringic acid	0-3	cyclin D1	Homo sapiens	78-87
33757521-8	2021	RESULTS: Artesunate treatment inhibited CS-induced airway inflammation and oxidative stress in a dose-dependent manner and significantly reduced airway remodelling by inhibiting alpha-smooth muscle actin (alpha-SMA) and cyclin D1 expression.	Artesunate	9-19	cyclin D1	Homo sapiens	220-229
33757521-10	2021	Furthermore, PPAR-gamma knockdown by siRNA transfection abolished artesunate-mediated inhibition of HBSM cell proliferation by activiting the TGF-beta1/Smad2/3 signalling pathway and downregulating the expression of alpha-SMA and cyclin D1 in HBSM cells.	Artesunate	66-76	cyclin D1	Homo sapiens	230-239
33538277-0	2021	Ultrasensitive detection of cyclin D1 by a self-enhanced ECL immunosensor based on Bi2S3 quantum dots.	Bismuth sulfide (Bi2S3)	83-88	cyclin D1	Homo sapiens	28-37
33538277-5	2021	In addition, on the basis of Bi2S3 QDs, an ECL immunosensor was used for the ultrasensitive measurement of cyclin D1 (CCND1).	Bismuth sulfide (Bi2S3)	29-34	cyclin D1	Homo sapiens	107-116
33538277-5	2021	In addition, on the basis of Bi2S3 QDs, an ECL immunosensor was used for the ultrasensitive measurement of cyclin D1 (CCND1).	Bismuth sulfide (Bi2S3)	29-34	cyclin D1	Homo sapiens	118-123
33728745-5	2021	Here, we investigated the effects of o,p"-DDT, p,p"-DDT, and endosulfan and of hormones estradiol, testosterone, and progesterone on the expression of estrogen, progesterone, and androgen receptors (ER, PR, and AR) and of their target genes (KLF4, VEGFA, CCND1, PRLR, CDKN1A, and BCL6) in MCF-7 and MDA-MB-231 cells.	Progesterone	117-129	cyclin D1	Homo sapiens	255-260
33728745-7	2021	As corroborated by an experiment with ER, PR, and AR negative MDA-MB-231 cells, the change in the expression of KLF4, VEGFA, CCND1, and PRLR in MCF-7 cells treated with o,p"-DDT and the change in CDKN1A and PRLR expression in MCF-7 cells treated with p,p"-DDT are likely mediated by ER, PR, and AR pathways.	o,p'-DDT	169-177	cyclin D1	Homo sapiens	125-130
33731248-6	2021	Emodin also significantly inhibited the activation of the Wnt/-catenin signaling pathway by downregulating the expression of related downstream target genes, including TCF4, cyclin D1, and c-Myc.	Emodin	0-6	cyclin D1	Homo sapiens	174-183
33719846-12	2021	Baicalin enhanced the effect of cisplatin on promoting apoptosis, arresting cell on S stage and triggering DNA damage accompanied with the upregulation of Bcl-2-associated X protein (Bax) and downregulation of B-cell lymphoma 2 (Bcl-2) and Cyclin D1 in A549/DPP cells.	baicalin	0-8	cyclin D1	Homo sapiens	240-249
33719846-12	2021	Baicalin enhanced the effect of cisplatin on promoting apoptosis, arresting cell on S stage and triggering DNA damage accompanied with the upregulation of Bcl-2-associated X protein (Bax) and downregulation of B-cell lymphoma 2 (Bcl-2) and Cyclin D1 in A549/DPP cells.	Cisplatin	32-41	cyclin D1	Homo sapiens	240-249
33691557-6	2022	Moreover, GLY also exerted cell cycle arrest in C33A cells at G0/G1 phase which was associated with the decreased expression of cyclin D1 and cyclin-dependent kinase 4 (CDK4) along with the increased expression of CDK inhibitor p21Cip1.	Glycyrrhizic Acid	10-13	cyclin D1	Homo sapiens	128-137
33687886-7	2022	Also, nano-capsulated hydroxytyrosol showed more significant effects on the up-regulation of CDKN1A and CDKN1B genes, and down-regulation of the CCND1 gene in the colorectal cancer cells.	3,4-dihydroxyphenylethanol	22-36	cyclin D1	Homo sapiens	145-150
33867823-5	2021	FZU-0025-065 suppresses the expression of cell cycle dependent kinase 4 (CDK4), Cyclin D1 and Cyclin B1; meanwhile, elevates the expression of cell cycle dependent kinase inhibitor p21 and p27.	fzu-0025-065	0-12	cyclin D1	Homo sapiens	80-89
33534411-5	2021	Further study showed that sesamin-induced cell cycle arrest and decreased the expression of Cyclin D1 significantly and dose-dependently in HCT116 cells.	sesamin	26-33	cyclin D1	Homo sapiens	92-101
33788727-6	2021	Furthermore, amentoflavone not only triggered expression of p27, cleaved caspase-3, -8 also reduced NF-kappaB signaling, protein levels of matrix metalloproteinase (MMP)-2, -9, Cyclin-D1, and vascular endothelial growth factor (VEGF).	amentoflavone	13-26	cyclin D1	Homo sapiens	177-186
33652909-8	2021	The cell-based analysis further indicated that metformin treatment regulated p38/JNK pathway to reduce Cyclin D1 and Bcl-2 expressions.	Metformin	47-56	cyclin D1	Homo sapiens	103-112
33649777-8	2021	In addition, treatment with TSA suppressed cancer cell proliferation via G2/M arrest, as well as upregulating p21 and downregulating cyclin D1 expression.	trichostatin A	28-31	cyclin D1	Homo sapiens	133-142
33649826-7	2021	It was also demonstrated that curcumin regulated the cell cycle- and apoptosis-related proteins (cyclin D1, p21, Bcl2, cleaved-caspase-3 and cleaved-PARP), leading to cell cycle arrest and apoptosis in both ML-2 and OCI-AML5 cells.	Curcumin	30-38	cyclin D1	Homo sapiens	97-106
33386469-9	2021	Western blotting assays showed that the expression levels of EZH2 and cyclin-D1 proteins in arsenite-transformed cells increased.	arsenite	92-100	cyclin D1	Homo sapiens	70-79
33576447-11	2021	Morusin suppressed the activity of beta-catenin signaling via the inactivation of Akt; the executive beta-catenin/TCF4 complex and the downstream targets, c-Myc, survivin and cyclin D1, were also downregulated.	morusin	0-7	cyclin D1	Homo sapiens	175-184
33484789-4	2021	Exposure to E2 and Fen induced the cell growth and survival ability of MCF-7 cells by increasing the S-phase cells and regulating the cell cycle-related proteins (Cyclin D1 and E1, p21 and p27).	Estradiol	12-14	cyclin D1	Homo sapiens	163-172
33484789-4	2021	Exposure to E2 and Fen induced the cell growth and survival ability of MCF-7 cells by increasing the S-phase cells and regulating the cell cycle-related proteins (Cyclin D1 and E1, p21 and p27).	N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide	19-22	cyclin D1	Homo sapiens	163-172
33605558-10	2021	Additionally, downregulation of CCND1 by miR-194 in GC further led to cell growth inhibition and cell cycle arrest.	mir-194	41-48	cyclin D1	Homo sapiens	32-37
33624781-0	2021	Vitamin C affects G0/G1 cell cycle and autophagy by downregulating of cyclin D1 in gastric carcinoma cells.	Ascorbic Acid	0-9	cyclin D1	Homo sapiens	70-79
33624781-5	2021	Meanwhile, vitamin C treatment resulted in downregulation of cell cycle-related protein Cyclin D1.	Ascorbic Acid	11-20	cyclin D1	Homo sapiens	88-97
33624781-7	2021	These results suggest that vitamin C has the antiproliferation effect on gastric carcinoma cells via the regulation of cell cycle and autophagy by Cyclin D1.	Ascorbic Acid	27-36	cyclin D1	Homo sapiens	147-156
33605558-12	2021	MiR-194 suppresses GC cell growth mainly through targeting CCND1 and induction of cell cycle arrest.	mir-194	0-7	cyclin D1	Homo sapiens	59-64
33385409-9	2021	Cell cycle disruption at the G1 phase via down-regulation of cyclin D1 and Cyclin-dependent kinase 4 (CDK4) was another proved mechanism by which HLCA exerts its antiproliferative effects on the ovarian cell lines, OVCAR-3 and Caov-4, especially at relatively lower concentrations.	hlca	146-150	cyclin D1	Homo sapiens	61-70
33669781-7	2021	In addition, downregulation of p53 and/or cyclin D1 may also impact the responsiveness of HEC-1-A and KLE cells to cisplatin.	Cisplatin	115-124	cyclin D1	Homo sapiens	42-51
33670598-7	2021	Importantly, we also show that the combined treatment between FR054 and the pan-RAS inhibitor BI-2852 has an additive negative effect on cell proliferation and survival by means of the suppression of both Akt activity and cyclin D1 expression.	BI-2852	94-101	cyclin D1	Homo sapiens	222-231
33628179-4	2020	The cellular mechanism study suggested that VO(hntdtsc)(NPIP) inhibited the cell proliferation via arresting the cell cycle at G0/G1 phase through the p16-cyclin D1-CDK4-p-Rb pathway and inducing cell apoptosis through mitochondrial-dependent apoptosis pathway on HeLa cells.	vo(hntdtsc)	44-55	cyclin D1	Homo sapiens	155-164
33628179-4	2020	The cellular mechanism study suggested that VO(hntdtsc)(NPIP) inhibited the cell proliferation via arresting the cell cycle at G0/G1 phase through the p16-cyclin D1-CDK4-p-Rb pathway and inducing cell apoptosis through mitochondrial-dependent apoptosis pathway on HeLa cells.	4-nitrophenyl myo-inositol-1-phosphate	56-60	cyclin D1	Homo sapiens	155-164
33341705-4	2021	CCND1 amplification was examined in paraffin-embedded skin biopsies and excisions using a dual-probes fluorescence in situ hybridization (FISH) (11q13 and CEP11).	Paraffin	36-44	cyclin D1	Homo sapiens	0-5
33546391-7	2021	Concordantly, AMTA treatment of MC cells also significantly decreased protein levels of oestrogen-regulated CCND1 in a dose-dependent manner.	amta	14-18	cyclin D1	Homo sapiens	108-113
33538198-9	2021	Furthermore, fenofibrate could significantly increase the expression of cell cycle related protein (CyclinD1, CDK2)and cell proliferation related proteins (PCNA).	Fenofibrate	13-24	cyclin D1	Homo sapiens	100-108
33360419-10	2021	In addition, HES treatment reduced the mRNA level of p21 but increased the mRNA level of cyclin D1 and p53 in the mammosphere.	Hesperidin	13-16	cyclin D1	Homo sapiens	89-98
33708885-0	2021	FEN1 is a prognostic biomarker for ER+ breast cancer and associated with tamoxifen resistance through the ERalpha/cyclin D1/Rb axis.	Tamoxifen	73-82	cyclin D1	Homo sapiens	114-126
33708885-9	2021	Importantly, FEN1 over-expression could activate tamoxifen resistance through the ERalpha/cyclin D1/Rb axis.	Tamoxifen	49-58	cyclin D1	Homo sapiens	90-102
33708885-10	2021	Conclusions: As a biomarker of tamoxifen effectiveness, FEN1 participates in tamoxifen resistance through ERalpha/cyclin D1/Rb axis.	Tamoxifen	31-40	cyclin D1	Homo sapiens	114-126
33708885-10	2021	Conclusions: As a biomarker of tamoxifen effectiveness, FEN1 participates in tamoxifen resistance through ERalpha/cyclin D1/Rb axis.	Tamoxifen	77-86	cyclin D1	Homo sapiens	114-126
33521925-8	2021	We show that DFX unfolds its cytotoxic effect by a rapid induction of reactive oxygen species (ROS) that leads to oxidative stress and severe DNA damage and by triggering CD1 proteolysis in a mechanism that requires its phosphorylation on T286 by glycogen synthase kinase-3beta (GSK3beta).	Deferasirox	13-16	cyclin D1	Homo sapiens	171-174
33521925-9	2021	Moreover, we demonstrate that DFX mediates CD1 proteolysis by repressing the phosphatidylinositol 3-kinase (PI3K)/AKT/GSK3beta pathway via ROS generation.	Deferasirox	30-33	cyclin D1	Homo sapiens	43-46
33521925-9	2021	Moreover, we demonstrate that DFX mediates CD1 proteolysis by repressing the phosphatidylinositol 3-kinase (PI3K)/AKT/GSK3beta pathway via ROS generation.	Reactive Oxygen Species	139-142	cyclin D1	Homo sapiens	43-46
33521925-0	2021	Deferasirox induces cyclin D1 degradation and apoptosis in mantle cell lymphoma in a reactive oxygen species- and GSK3beta-dependent mechanism.	Deferasirox	0-11	cyclin D1	Homo sapiens	20-29
33521925-0	2021	Deferasirox induces cyclin D1 degradation and apoptosis in mantle cell lymphoma in a reactive oxygen species- and GSK3beta-dependent mechanism.	Reactive Oxygen Species	85-108	cyclin D1	Homo sapiens	20-29
33629301-6	2021	CONCLUSIONS: Our results demonstrated that kaempferol suppressed GBC progression through activation of the CDK4/CDK6/cyclin D1 signaling pathway, suggesting that it might be a potential anti-tumor agent for clinical treatment of GBC.	Kaempferols	43-53	cyclin D1	Homo sapiens	117-126
33416182-6	2021	In addition, Selumetinib induced cell cycle arrest at the G0/G1 phase by downregulating the expression levels of cyclin D1 and p21 and upregulating those of p27 compared with those in the control cells.	AZD 6244	13-24	cyclin D1	Homo sapiens	113-122
32885355-5	2021	Artesunate induced G1 phase arrest by downregulating cyclin D1/D2, CDK2/6 and c-Myc.	Artesunate	0-10	cyclin D1	Homo sapiens	53-65
33416149-7	2021	Following garcinol treatment the expression levels of p53 and p21 were increased, while the expression levels of CDK2, CDK4, cyclin D1 and cyclin B1 were gradually decreased in a dose-dependent manner in both ISH and HEC-1B cells.	garcinol	10-18	cyclin D1	Homo sapiens	125-134
33486902-12	2021	Signal transduction pathway analysis showed that after Bel-7402 cells acquired resistance to 5-Fu, CCND1, MCM2, and MCM3 gene expression was upregulated in the G1 to S cell cycle control signal transduction pathway, CDKN1C and CCNG2 gene expression was downregulated, and MCM2 and MCM3 gene expression was upregulated in the DNA replication signal transduction pathway.	Fluorouracil	93-97	cyclin D1	Homo sapiens	99-104
33530915-7	2021	After inhibiting autophagy, Bufalin significantly inhibited the protein expression of P-AKT, Cyclin D1, MMP-2, MMP-9 and VEGF in HCC-LM3 cells.	bufalin	28-35	cyclin D1	Homo sapiens	93-102
33554791-4	2021	RESULTS: PI3K inhibitor ZSTK474 could inhibit the proliferation and tumorigenicity of U937 cell, induce G1 cell cycle arrest and promote cell apoptosis, and enhance intracellular ROS production and decrease MMP, downregulate Cyclin D1, p-Rb, BCL-2 and upregulate p27, caspase-9, caspase-3, PARP and BAX.	ZSTK474	24-31	cyclin D1	Homo sapiens	225-234
33183867-6	2021	Further mechanism studies significantly indicated that compound 5h could block MDA-MB-231 cell cycle arrest in G0/G1 phase by down regulating cyclin D1 and CDK4, and induce apoptosis by up-regulation of Bax, down-regulation of Caspase-3, PARP and Bcl-2 proteins, resulting in the reduction of DNA synthesis and cell division arrest.	5h	64-66	cyclin D1	Homo sapiens	142-151
33629301-0	2021	Kaempferol suppresses proliferation and induces apoptosis and DNA damage in human gallbladder cancer cells through the CDK4/CDK6/cyclin D1 pathway.	Kaempferols	0-10	cyclin D1	Homo sapiens	129-138
33629301-4	2021	In addition, the expression levels of CDK4, CDK6 and cyclin D1, which are members of the CDK4/CDK6/cyclin D1 signaling pathway, were also decreased by kaempferol.	Kaempferols	151-161	cyclin D1	Homo sapiens	53-62
33629301-4	2021	In addition, the expression levels of CDK4, CDK6 and cyclin D1, which are members of the CDK4/CDK6/cyclin D1 signaling pathway, were also decreased by kaempferol.	Kaempferols	151-161	cyclin D1	Homo sapiens	99-108
33491760-11	2021	The expression of miR-340-5p was significantly upregulated after treatment, and overexpression of miR-340-5p inhibited the proliferation of HuCCT-1 cells and decreased the levels of cyclin D1.	mir-340-5p	18-28	cyclin D1	Homo sapiens	182-191
33491760-11	2021	The expression of miR-340-5p was significantly upregulated after treatment, and overexpression of miR-340-5p inhibited the proliferation of HuCCT-1 cells and decreased the levels of cyclin D1.	mir-340-5p	98-108	cyclin D1	Homo sapiens	182-191
33491760-14	2021	In conclusion, the present study indicated that aspirin partially inhibited cholangiocarcinoma cell proliferation and tumor growth by inducing G0/G1 phase cell cycle arrest, potentially through the miR-340-5p/cyclin D1 axis.	Aspirin	48-55	cyclin D1	Homo sapiens	209-218
33051972-10	2021	It is further confirmed by analyzing cancer cell progression proteins, that is, proliferating cell nuclear antigen and cyclin D1 expressions in untreated and dieckol-treated PANC-1 cells.	dieckol	158-165	cyclin D1	Homo sapiens	119-128
33416164-7	2021	Silencing of TCF7 downregulated the expression levels of CTNNB1, CCND1, and ABCC2, and therefore inhibited proliferation, weakened colony formation, and increased the drug sensitivity of imatinib-resistant cells.	Imatinib Mesylate	187-195	cyclin D1	Homo sapiens	65-70
33509758-5	2021	Treatment with dihydromyricetin obviously suppressed the proliferation and migration of BGC-823 cells, significantly reduced the expression levels of cyclin D1, cyclin E1 and Ncadherin, enhanced E-cadherin expression, inhibited the phosphorylation of Akt and stat3, and downregulated HMGB1 expression in the cells.	dihydromyricetin	15-31	cyclin D1	Homo sapiens	150-159
33574763-0	2020	Osthole Alleviates Neointimal Hyperplasia in Balloon-Induced Arterial Wall Injury by Suppressing Vascular Smooth Muscle Cell Proliferation and Downregulating Cyclin D1/CDK4 and Cyclin E1/CDK2 Expression.	osthol	0-7	cyclin D1	Homo sapiens	158-167
33259807-12	2021	AMG900 decreased CDK2, CDK4, CDK6, cyclin D1 and cyclin D3 expression, whereas p18, p21 and p27 expression increased.	N-(4-((3-(2-amino-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine	0-6	cyclin D1	Homo sapiens	35-44
33519190-0	2021	Paeoniflorin Sensitizes Breast Cancer Cells to Tamoxifen by Downregulating microRNA-15b via the FOXO1/CCND1/beta-Catenin Axis.	peoniflorin	0-12	cyclin D1	Homo sapiens	102-107
33519190-0	2021	Paeoniflorin Sensitizes Breast Cancer Cells to Tamoxifen by Downregulating microRNA-15b via the FOXO1/CCND1/beta-Catenin Axis.	Tamoxifen	47-56	cyclin D1	Homo sapiens	102-107
33519190-14	2021	Conclusion: Pae inhibits 4-OHT resistance in BC cells by regulating the miR-15b/FOXO1/CCND1/beta-catenin pathway.	4,17 beta-dihydroxy-4-androstene-3-one	25-30	cyclin D1	Homo sapiens	86-91
33471569-12	2021	Combining API and TMZ significantly inhibited the protein expression of p-AKT, cyclin D1, Bcl-2, Matrix Metallopeptidase 2, and Matrix Metallopeptidase 9.	Apigenin	10-13	cyclin D1	Homo sapiens	79-88
33471569-12	2021	Combining API and TMZ significantly inhibited the protein expression of p-AKT, cyclin D1, Bcl-2, Matrix Metallopeptidase 2, and Matrix Metallopeptidase 9.	Temozolomide	18-21	cyclin D1	Homo sapiens	79-88
33248230-4	2021	Our results showed that both octreotide and pasireotide reduced TT cell proliferation (-35.2+-12.1%, p<0.001, and -25.3+-24.8%, p<0.05, at 10-8 M, respectively), with concomitant inhibition of ERK phosphorylation and cyclin D1 expression.	Octreotide	29-39	cyclin D1	Homo sapiens	217-226
33450878-6	2021	Further analyses exhibited that berberine treatment caused G0/G1 phase arrest at 48 h due to high cyclin D1 (CCND1) and low cyclin-dependent kinase 4 (CDK4) protein and mRNA levels, simultaneous downregulation of human telomerase reverse transcriptase (TERT) mRNA and human telomerase RNA component (TERC) levels, as well as a decrease in the TERT protein level and telomerase activity.	Berberine	32-41	cyclin D1	Homo sapiens	98-107
33450878-6	2021	Further analyses exhibited that berberine treatment caused G0/G1 phase arrest at 48 h due to high cyclin D1 (CCND1) and low cyclin-dependent kinase 4 (CDK4) protein and mRNA levels, simultaneous downregulation of human telomerase reverse transcriptase (TERT) mRNA and human telomerase RNA component (TERC) levels, as well as a decrease in the TERT protein level and telomerase activity.	Berberine	32-41	cyclin D1	Homo sapiens	109-114
33438566-13	2021	Moreover, anlotinib downregulated the expression of survivin, cyclin D1, CDK4, caspase-3, Bcl-2, MMP-2, MMP-9, vimentin and N-cadherin, but up-regulated cleaved-caspase-3, Bax and E-cadherin and blocked the activity of the PI3K/AKT in HCT-8/5-FU cells.	anlotinib	10-19	cyclin D1	Homo sapiens	62-71
32819236-11	2021	DAS and DADS also induced cellcycle arrest in G0/G1 phase, which was supported by the downregulation of cyclin D1 and CDK4 and upregulation of CDK inhibitors p21WAF1/CIP1 and p27KIP1 in Caski cells.	allyl sulfide	0-3	cyclin D1	Homo sapiens	104-113
32819236-11	2021	DAS and DADS also induced cellcycle arrest in G0/G1 phase, which was supported by the downregulation of cyclin D1 and CDK4 and upregulation of CDK inhibitors p21WAF1/CIP1 and p27KIP1 in Caski cells.	diallyl disulfide	8-12	cyclin D1	Homo sapiens	104-113
33146000-4	2021	Furthermore, arbutin exposure decreased the protein levels of MTHFD1L, CCND1, and p-AKT/p-mTOR.	Arbutin	13-20	cyclin D1	Homo sapiens	71-76
33155660-0	2021	Pimozide augments bromocriptine lethality in prolactinoma cells and in a xenograft model via the STAT5/cyclin D1 and STAT5/Bcl-xL signaling pathways.	Pimozide	0-8	cyclin D1	Homo sapiens	103-112
33155660-9	2021	Collectively, these data indicated that pimozide treatment reduced prolactinoma growth by targeting both proliferating cells and stem cells, at least in part, by inhibiting the STAT5/Bcl-xL and STAT5/cyclin D1 signaling pathways.	Pimozide	40-48	cyclin D1	Homo sapiens	200-209
33390782-5	2021	Single treatment of both mTOR inhibitors induced a significant G1 cell cycle arrest and combination treatment with Dasatinib reduced the expression of cell cycle regulator cyclin D1 or increased the expression of cell cycle inhibitor p21.	Dasatinib	115-124	cyclin D1	Homo sapiens	172-181
33240422-9	2021	TE1 cells were also arrested in the G0/G1 phase when transfected with pcTERT-melittin, followed by the decline of CDK4, CDK6 and cyclin D1 expression levels.	pctert-melittin	70-85	cyclin D1	Homo sapiens	129-138
33414642-8	2020	Induction of apoptosis by VCX treatment induced cell cycle arrest at G0/G1 phase with inhibition of cell proliferator genes, cyclin D1 and E2F1.	venetoclax	26-29	cyclin D1	Homo sapiens	125-134
32776713-5	2021	Moreover, honokiol attenuated the expression of alpha smooth muscle actin (alpha-SMA), transforming growth factor beta 1 (TGF-beta1), phospho-Smad3, phospho-AKT, cyclin D1, c-Myc, Wnt3a, beta-catenin, and activated phosphorylation of glycogen synthase kinase 3 beta (GSK3beta) in HSCs.	honokiol	10-18	cyclin D1	Homo sapiens	162-171
33390115-7	2020	Also, free and nano-encapsulated hydroxytyrosol increased the expression of P21 and P27 genes and reduced the expression of Cyclin D1 in breast cancer cells.	3,4-dihydroxyphenylethanol	33-47	cyclin D1	Homo sapiens	124-133
33817287-8	2020	Meanwhile, the expression levels of cyclinD1, CDK4, and Bcl-2 were suppressed in cells with decitabine exposure, but Bax and caspase-3 expression levels were upregulated.	Decitabine	92-102	cyclin D1	Homo sapiens	36-44
33302980-12	2020	Moreover, naringin stimulated the gene expression of beta-catenin and cyclin D1 in fibroblasts, and the effect could be inhibited by DKK-1.	naringin	10-18	cyclin D1	Homo sapiens	70-79
33344441-10	2020	Meanwhile, dasatinib also suppressed the expression of markers relating cell cycle, cyclin D1, D3, and CDK2, and increased the levels of markers involved in cell apoptosis, cleaved caspase-3 and caspase-7 by downregulating phosphorylated LIMK1 (p-LIMK1) and cofilin (p-cofilin).	Dasatinib	11-20	cyclin D1	Homo sapiens	84-97
33227547-6	2020	Blocking cAMP/PKA/CREB/ATF3 signaling attenuated the promoting effect of IS on cyclin D1 expression and VSMC proliferation.	Cyclic AMP	9-13	cyclin D1	Homo sapiens	79-88
33287214-6	2020	In RWPE-1 cells, arecoline increased the expression of cyclin-dependent kinase (CDK)-1, p21, and cyclins B1 and D3, decreased the expression of CDK2, and had no effects on CDK4 and cyclin D1 expression.	Arecoline	17-26	cyclin D1	Homo sapiens	181-190
33287214-8	2020	In LNCaP cells, arecoline decreased CDK2, CDK4, and cyclin D1 expression; increased p21, p27, and cyclin D3 expression; had no effects on CDK1 and cyclin B1 expression.	Arecoline	16-25	cyclin D1	Homo sapiens	52-61
32013613-11	2020	Our results showed that TA I induced G0/G1 phase arrest through downregulation of cyclin D1 expression and upregulation of p21 expression.	tanshinone	24-28	cyclin D1	Homo sapiens	82-91
32988624-12	2020	CONCLUSIONS: Olaparib reduced expression of cyclin D1, which positively correlated with PARP-1 levels.	olaparib	13-21	cyclin D1	Homo sapiens	44-53
32623699-10	2020	We also found that bufalin induced both AR dephosphorylation and cell cycle-related kinase (CCRK) degradation to inhibit beta-catenin/TCF signaling, which subsequently led to cell cycle arrest via cyclin D1 down-regulation and p21 up-regulation, resulting in HCC regression.	bufalin	19-26	cyclin D1	Homo sapiens	197-206
32504027-11	2020	CCND1 was speculated as the target of miR-141-3p and miR-141-3p inhibited CCND1 expression significantly.	141-3p	42-48	cyclin D1	Homo sapiens	0-5
32504027-11	2020	CCND1 was speculated as the target of miR-141-3p and miR-141-3p inhibited CCND1 expression significantly.	141-3p	42-48	cyclin D1	Homo sapiens	74-79
32504027-11	2020	CCND1 was speculated as the target of miR-141-3p and miR-141-3p inhibited CCND1 expression significantly.	mir-141-3p	38-48	cyclin D1	Homo sapiens	0-5
32504027-11	2020	CCND1 was speculated as the target of miR-141-3p and miR-141-3p inhibited CCND1 expression significantly.	mir-141-3p	38-48	cyclin D1	Homo sapiens	74-79
33125094-12	2020	Treatment with the NF-kappaB inhibitor, BAY 11-7082, decreased Cyclin D1 and Bcl-2 expression levels.	3-(4-methylphenylsulfonyl)-2-propenenitrile	40-51	cyclin D1	Homo sapiens	63-72
33011217-10	2020	KEY FINDINGS: Niclosamide was found to inhibit expression and activation of STAT3 in a concentration- and time-dependent manner, thereby downregulating STAT3 downstream targets including survivin and cyclin-D1 to induce apoptosis and cell cycle arrest.	Niclosamide	14-25	cyclin D1	Homo sapiens	200-209
32866294-9	2020	Differential methylation analysis identified CCND1, encoding cyclin D1, as a plausible cancer driver gene in these tumours because hypermethylation of the CCND1 promoter was specific for GCTBs.	gctbs	187-192	cyclin D1	Homo sapiens	61-70
32866294-9	2020	Differential methylation analysis identified CCND1, encoding cyclin D1, as a plausible cancer driver gene in these tumours because hypermethylation of the CCND1 promoter was specific for GCTBs.	gctbs	187-192	cyclin D1	Homo sapiens	155-160
32731110-0	2020	Downregulation of miR-4755-5p promotes fluoride-induced osteoblast activation via tageting Cyclin D1.	Fluorides	39-47	cyclin D1	Homo sapiens	91-100
32731110-15	2020	RESULTS: In the fluoride-exposed population, the results showed that with the increase in UF content, the expression of miR-4755-5p decreased gradually, while the mRNA transcription and protein expression of Cyclin D1 increased gradually.	Fluorides	16-24	cyclin D1	Homo sapiens	208-217
32731110-17	2020	Subsequently, in human osteoblasts treated with sodium fluoride (NaF), the results also showed that NaF caused low expression of miR-4755-5p and increased expression of Cyclin D1.	Sodium Fluoride	48-63	cyclin D1	Homo sapiens	169-178
32731110-20	2020	CONCLUSION: The results demonstrate that fluoride exposure induced the downregulation of miR-4755-5p and downregulated miR-4755-5p promoted fluoride-induced osteoblast activation by increasing Cyclin D1 protein expression.	Fluorides	41-49	cyclin D1	Homo sapiens	193-202
32731110-20	2020	CONCLUSION: The results demonstrate that fluoride exposure induced the downregulation of miR-4755-5p and downregulated miR-4755-5p promoted fluoride-induced osteoblast activation by increasing Cyclin D1 protein expression.	Fluorides	140-148	cyclin D1	Homo sapiens	193-202
32515250-11	2020	Additionally, IKKgamma silencing inhibited expression of Bcl-XL, Bcl-2, and cyclin D1.Conclusions: Curcumin enhances LSCC radiosensitivity via NF-KappaB inhibition by suppressing IKKgamma expression.	Curcumin	99-107	cyclin D1	Homo sapiens	76-85
33011221-9	2020	In addition, diltiazem co-treatment decreased the expressions of stem cell markers CD24 and CD44, increased the expressions of Bax and cleaved caspase 3, enhanced DNA fragmentation, and attenuated cyclin D1 and P-gp expressions as compared to cells treated with either gemcitabine or 5-FU alone.	Diltiazem	13-22	cyclin D1	Homo sapiens	197-206
33154777-7	2020	In addition, flow cytometry and western blot analysis demonstrated that hypoxia (2% O2) promoted cell cycle progression in ccRCC cells with the increased expression of G1-S transition-associated proteins, namely cyclin-dependent kinase (CDK)4 and cyclin D1, while downregulation of NICD3 exerted negative effects on cell cycle progression, and the expression levels of CDK4 and cyclin D1.	Oxygen	84-86	cyclin D1	Homo sapiens	247-256
33154777-7	2020	In addition, flow cytometry and western blot analysis demonstrated that hypoxia (2% O2) promoted cell cycle progression in ccRCC cells with the increased expression of G1-S transition-associated proteins, namely cyclin-dependent kinase (CDK)4 and cyclin D1, while downregulation of NICD3 exerted negative effects on cell cycle progression, and the expression levels of CDK4 and cyclin D1.	Oxygen	84-86	cyclin D1	Homo sapiens	378-387
33154777-9	2020	Following transfection of the vector containing the NICD3 coding sequence, HIF-2alpha, CDK4, cyclin D1 and proliferating cell nuclear antigen expression, that were inhibited by RO4929097 in hypoxia, were rescued.	2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide	177-186	cyclin D1	Homo sapiens	93-102
33262612-13	2020	Berberine also reduced mutp53 content and caused G2 phase arrest in U251 cells with a concurrent decrease in p21, cyclin D1, and cyclin B1 content.	Berberine	0-9	cyclin D1	Homo sapiens	114-123
33361852-5	2020	Sample preparation was performed by a standard immunofluorescent assay for intracellular proteins using the FITC labelled Mouse Anti-Human Cyclin D1Antibody Set.	Fluorescein-5-isothiocyanate	108-112	cyclin D1	Homo sapiens	139-148
33137708-5	2020	MiR-381-3p was a typical representative of these miRNAs and its redistribution between mitochondria and cytosol regulated the network consisting of downstream molecules (P53, P21, CCND1, and MYC) by inhibiting its target genes (LRP6 and NFIA) to promote apoptosis and inhibit proliferation in endothelial cells.	mir-381-3p	0-10	cyclin D1	Homo sapiens	180-185
33027592-7	2020	In addition, aaptamine arrested cell cycle at G1 phase via selectively abating cell cycle regulation drivers (CDK2/4 and Cyclin D1/E).	aaptamine	13-22	cyclin D1	Homo sapiens	121-130
33222668-7	2021	At the molecular level, OSI-027 simultaneously blocked mTORC1 and mTORC2 activation, and resulted in the downregulation of phosphor-Akt, phpspho-p70S6k, phosphor-4EBP1, cyclin D1, and cyclin-dependent kinase4 (CDK4).	OSI 027	24-31	cyclin D1	Homo sapiens	169-178
33184448-8	2021	Furthermore, we revealed that AVT concentration-dependently suppressed USP10-mediated deubiquitination on CCND1 therefore inducing CCND1 protein degradation.	acevaltrate	30-33	cyclin D1	Homo sapiens	106-111
33184448-8	2021	Furthermore, we revealed that AVT concentration-dependently suppressed USP10-mediated deubiquitination on CCND1 therefore inducing CCND1 protein degradation.	acevaltrate	30-33	cyclin D1	Homo sapiens	131-136
33172123-8	2020	SOX2 and three of its target genes (CCND1, BMP4, and DKK1) were also decreased after treatment with quetiapine.	Quetiapine Fumarate	100-110	cyclin D1	Homo sapiens	36-41
33177647-4	2020	Coffee decoction cooperated with tamoxifen to induce cell-cycle arrest and apoptotic cell death, which may have been mediated by decreases in cyclin D1 expression and the activation of p53 tumor suppressor.	Tamoxifen	33-42	cyclin D1	Homo sapiens	142-151
33139730-1	2020	Cyclin D1 is one of the most important oncoproteins that drives cancer cell proliferation and associates with tamoxifen resistance in breast cancer.	Tamoxifen	110-119	cyclin D1	Homo sapiens	0-9
33139730-2	2020	Here, we identify a lncRNA, DILA1, which interacts with Cyclin D1 and is overexpressed in tamoxifen-resistant breast cancer cells.	Tamoxifen	90-99	cyclin D1	Homo sapiens	56-65
33139730-5	2020	High expression of DILA1 is associated with overexpressed Cyclin D1 protein and poor prognosis in breast cancer patients who received tamoxifen treatment.	Tamoxifen	134-143	cyclin D1	Homo sapiens	58-67
33139730-6	2020	This study shows the previously unappreciated importance of post-translational dysregulation of Cyclin D1 contributing to tamoxifen resistance in breast cancer.	Tamoxifen	122-131	cyclin D1	Homo sapiens	96-105
33139730-7	2020	Moreover, it reveals the novel mechanism of DILA1 in regulating Cyclin D1 protein stability and suggests DILA1 is a specific therapeutic target to downregulate Cyclin D1 protein and reverse tamoxifen resistance in treating breast cancer.	Tamoxifen	190-199	cyclin D1	Homo sapiens	64-73
33109561-0	2020	3EZ, 20Ac-ingenol-induced Apoptosis in Chemoresistant Cancers With Cyclin D1 Accumulation.	3EZ	0-3	cyclin D1	Homo sapiens	67-76
32671454-0	2020	A case of "double hit" mantle cell lymphoma carrying CCND1 and MYC translocations relapsed/refractory to rituximab bendamustine cytarabine (R-BAC) and ibrutinib.	bendamustine cytarabine	115-138	cyclin D1	Homo sapiens	53-58
32671454-0	2020	A case of "double hit" mantle cell lymphoma carrying CCND1 and MYC translocations relapsed/refractory to rituximab bendamustine cytarabine (R-BAC) and ibrutinib.	r-bac	140-145	cyclin D1	Homo sapiens	53-58
32671454-0	2020	A case of "double hit" mantle cell lymphoma carrying CCND1 and MYC translocations relapsed/refractory to rituximab bendamustine cytarabine (R-BAC) and ibrutinib.	ibrutinib	151-160	cyclin D1	Homo sapiens	53-58
32417359-16	2020	Furthermore, simvastatin treatment led to reduced levels of mechanical signaling proteins involved in beta1 integrin downstream signaling, such as A-kinase anchor protein 13, Rho-associated protein kinase 1, myosin light-chain kinase, and cyclin D1.	Simvastatin	13-24	cyclin D1	Homo sapiens	239-248
33109561-0	2020	3EZ, 20Ac-ingenol-induced Apoptosis in Chemoresistant Cancers With Cyclin D1 Accumulation.	20ac-ingenol	5-17	cyclin D1	Homo sapiens	67-76
33109561-6	2020	CONCLUSION: 3EZ, 20Ac-ingenol-induced apoptosis might occur in cells with cyclin D1 accumulation through enhancing DDR, regardless of the cancer cell type.	3EZ, 20Ac-ingenol	12-29	cyclin D1	Homo sapiens	74-83
33000185-4	2020	Both in vitro and in vivo, a low concentration of NaHS (100 microM in vitro; 9 mg/kg in vivo) significantly promoted the viability of HC11 cells and the development of mammary glands by increasing the expression of the proliferative markers cyclin D1/3 and proliferating cell nuclear antigen.	sodium bisulfide	50-54	cyclin D1	Homo sapiens	241-252
33073770-4	2020	In addition, MHY2256 induced G0/G1 phase arrest of the cell cycle progression, which was accompanied by the reduction of cyclin D1 and cyclin E and the decrease of cyclin-dependent kinase 2, cyclin-dependent kinase 4, cyclin-dependent kinase 6, phosphorylated retinoblastoma protein, and E2F transcription factor 1.	mhy2256	13-20	cyclin D1	Homo sapiens	121-130
33044899-0	2020	miR-20b-5p functions as tumor suppressor microRNA by targeting cyclinD1 in colon cancer.	mir-20b-5p	0-10	cyclin D1	Homo sapiens	63-71
33044899-9	2020	CyclinD1 (CCND1) was identified as a direct target of miR-20b-5p.	mir-20b-5p	54-64	cyclin D1	Homo sapiens	0-8
33044899-9	2020	CyclinD1 (CCND1) was identified as a direct target of miR-20b-5p.	mir-20b-5p	54-64	cyclin D1	Homo sapiens	10-15
33044899-11	2020	Mechanically, the inhibition of cell cycle, migration, and invasion of CC cells mediated by miRNA-20b-5p are through regulating the CCND1/CDK4/FOXM1 axis.	mirna-20b-5p	92-104	cyclin D1	Homo sapiens	132-137
32660221-10	2020	Moreover, it can reduce the expression of CCND1 mRNA independent of the paclitaxel effect.	Paclitaxel	72-82	cyclin D1	Homo sapiens	42-47
32700164-2	2020	Here, we demonstrate that exposure to PFOS (10 microM) and PFOA (100 microM)-two contaminants ubiquitously found in human blood-for 72 h induced breast epithelial cell (MCF-10A cell line) proliferation and alteration of regulatory cell-cycle proteins (cyclin D1, CDK6, p21, p53, p27, ERK 1/2 and p38) that persisted after a multitude of cell divisions.	perfluorooctane sulfonic acid	38-42	cyclin D1	Homo sapiens	252-261
32700164-2	2020	Here, we demonstrate that exposure to PFOS (10 microM) and PFOA (100 microM)-two contaminants ubiquitously found in human blood-for 72 h induced breast epithelial cell (MCF-10A cell line) proliferation and alteration of regulatory cell-cycle proteins (cyclin D1, CDK6, p21, p53, p27, ERK 1/2 and p38) that persisted after a multitude of cell divisions.	perfluorooctanoic acid	59-63	cyclin D1	Homo sapiens	252-261
32994812-7	2020	Under normal glucose conditions, MET attenuated E2-induced cell proliferation and cyclin D1 gene expression, and increased total PGR and PGR-B transcript levels.	Estradiol	48-50	cyclin D1	Homo sapiens	82-91
32816241-6	2020	PI3K substrate Akt (at Ser473) as well as Wnt dependent beta-catenin and cyclin D1 activity was found to be upregulated by DMF pretreatment in Abeta1-42 treated cells.	Dimethyl Fumarate	123-126	cyclin D1	Homo sapiens	73-82
32934722-2	2020	Based on our previous phase 3 trial on TPF (docetaxel, cisplatin and fluorouracil) induction chemotherapy in patients with oral squamous cell carcinoma (OSCC), in which short-term prognostic and predictive values of cyclin D1 expression were reported, the present study aimed to determine the long-term predictive value of cyclin D1 expression in the same patients with OSCC who were eligible to receive TPF induction chemotherapy.	TPF	39-42	cyclin D1	Homo sapiens	216-225
32934722-2	2020	Based on our previous phase 3 trial on TPF (docetaxel, cisplatin and fluorouracil) induction chemotherapy in patients with oral squamous cell carcinoma (OSCC), in which short-term prognostic and predictive values of cyclin D1 expression were reported, the present study aimed to determine the long-term predictive value of cyclin D1 expression in the same patients with OSCC who were eligible to receive TPF induction chemotherapy.	TPF	39-42	cyclin D1	Homo sapiens	323-332
32934722-7	2020	Furthermore, patients with stage clinical nodal stage 2 (cN2) OSCC in the high cyclin D1 expression group benefitted from TPF induction chemotherapy (OS, P=0.024; DMFS, P=0.024), whilst patients with cN2 OSCC in the low cyclin D1 expression group did not benefit from this chemotherapy.	TPF	122-125	cyclin D1	Homo sapiens	79-88
33719271-10	2020	Conclusion: The betulinic acid regulates the proliferation of SGC-7901 cells by inhibiting the expressions of cyclin D1 and cyclin B1, which leads to cell cycle arrest and proliferative inhibition.	betulinic acid	16-30	cyclin D1	Homo sapiens	110-119
33204396-14	2020	We found seven putative genes predicted to be modulated by Rsv in the context of Doxo treatment: CCND1, CDH1, ESR1, HSP90AA1, MAPK3, PTPN11, and RPS6KB1.	Resveratrol	59-62	cyclin D1	Homo sapiens	97-102
33204396-14	2020	We found seven putative genes predicted to be modulated by Rsv in the context of Doxo treatment: CCND1, CDH1, ESR1, HSP90AA1, MAPK3, PTPN11, and RPS6KB1.	Doxorubicin	81-85	cyclin D1	Homo sapiens	97-102
33210592-10	2020	CCK-8 and Western blot assays showed that the proliferation was inhibited and the expression of PCNA and cyclin D1 were down-regulated after the cells were treated with miR-23b-3p mimic.	mir-23b-3p	169-179	cyclin D1	Homo sapiens	105-114
33681764-10	2021	In addition, guanine supplementation partially rescued IDHmut glioma cell growth, mTOR signaling, and Cyclin D1 protein expression in vitro.	Guanine	13-20	cyclin D1	Homo sapiens	102-111
33178666-3	2020	Curcumin inhibits Bcl-2, Bcl-XL, VEGF, c-Myc, ICAM-1, EGFR, STAT3 phosphorylation, and cyclin D1 genes involved in the various stages of breast, prostate, and gastric cancer proliferation, angiogenesis, invasion, and metastasis.	Curcumin	0-8	cyclin D1	Homo sapiens	87-96
33122919-0	2020	MicroRNA-16 Inhibits Glioblastoma Growth in Orthotopic Model by Targeting Cyclin D1 and WIP1.	microrna-16	0-11	cyclin D1	Homo sapiens	74-83
33122919-13	2020	In an orthotopic tumor model, overexpression of miR-16 inhibited tumor growth in vivo was accompanied with reduction in cyclin D1 and WIP1 expression in the xenografts.	mir-16	48-54	cyclin D1	Homo sapiens	120-129
33052706-0	2020	Upregulation of miR-519d-3p Inhibits Viability, Proliferation, and G1/S Cell Cycle Transition of Oral Squamous Cell Carcinoma Cells Through Targeting CCND1.	mir-519d-3p	16-27	cyclin D1	Homo sapiens	150-155
33061853-13	2020	Western blot analysis revealed that PD enhanced sensitivity to CDDP through the CDK4/6-cyclin D1-RB-E2F pathway.	Palladium	36-38	cyclin D1	Homo sapiens	87-96
33061853-13	2020	Western blot analysis revealed that PD enhanced sensitivity to CDDP through the CDK4/6-cyclin D1-RB-E2F pathway.	Cisplatin	63-67	cyclin D1	Homo sapiens	87-96
32645459-0	2020	lncRNA-OBFC2A targeted to Smad3 regulated Cyclin D1 influences cell cycle arrest induced by 1,4-benzoquinone.	quinone	92-108	cyclin D1	Homo sapiens	42-51
33050377-2	2020	Tamoxifen is the golden therapy for hormonal BC, but resistance of cancer cells to tamoxifen contributes to the recurrence of BC due to many reasons, including high levels of AIB1 and cyclin D1.	Tamoxifen	83-92	cyclin D1	Homo sapiens	184-193
33050377-10	2020	Interestingly, HAA2020 and dinaciclib showed a synergistic apoptotic and G1 cell cycle effect in MCF7 cells, which was supported by their synergistic CDK2, cyclin D1, and PCNA inhibition activities.	dinaciclib	27-37	cyclin D1	Homo sapiens	156-165
33008330-14	2020	MiR-20b-5p directly targeted both CCND1 and E2F1 in a dual luciferase assay, while antagomir-20b-5p downregulated the protein levels of CCND1 and E2F1.	mir-20b-5p	0-10	cyclin D1	Homo sapiens	34-39
32851455-0	2020	A methotrexate-associated lymphoproliferative disorder expressing CD10 and BCL6 with the IGH/CCND1 translocation.	Methotrexate	2-14	cyclin D1	Homo sapiens	93-98
32894380-8	2020	The limonoid suppressed the level of proteins associated with anti-apoptosis (survivin, Bcl-2, Bcl-xL), proliferation (cyclin D1), and invasion (MMP-9).	Limonins	4-12	cyclin D1	Homo sapiens	119-128
33112552-0	2020	Cyclin D1 G870A Polymorphism: Relation to the Risk of ALL Development, Prognosis Impact, and Methotrexate Cytotoxicity.	Methotrexate	93-105	cyclin D1	Homo sapiens	0-9
32645459-5	2020	In vitro study, results showed that benzene metabolic, 1,4-Benzoquinone (1,4-BQ), induced cell cycle arrest at the G1 phase accompanied with decreased expression of Cyclin D1 in a dose-dependently manner.	Benzene	36-43	cyclin D1	Homo sapiens	165-174
32645459-5	2020	In vitro study, results showed that benzene metabolic, 1,4-Benzoquinone (1,4-BQ), induced cell cycle arrest at the G1 phase accompanied with decreased expression of Cyclin D1 in a dose-dependently manner.	quinone	55-71	cyclin D1	Homo sapiens	165-174
32645459-5	2020	In vitro study, results showed that benzene metabolic, 1,4-Benzoquinone (1,4-BQ), induced cell cycle arrest at the G1 phase accompanied with decreased expression of Cyclin D1 in a dose-dependently manner.	quinone	73-79	cyclin D1	Homo sapiens	165-174
32645459-6	2020	Interestingly, lncRNA-OBFC2A overexpression was found in AHH-1 cells treated with 1,4-BQ and while interference with lncRNA-OBFC2A, the expression of Cyclin D1 were reversed.	quinone	82-88	cyclin D1	Homo sapiens	150-159
32645459-8	2020	In benzene exposed workers, the expression of lncRNA-OBFC2A and Smad3 increased while cyclin D1 decreased which was consistent with the in vitro experiment, meanwhile, the significant associations among them were also found.	Benzene	3-10	cyclin D1	Homo sapiens	86-95
32645459-9	2020	Thus, these findings indicate that lncRNA-OBFC2A targeted to Smad3 regulated cyclin D1 influences cell cycle arrest induced by 1,4-BQ.	quinone	127-133	cyclin D1	Homo sapiens	77-86
32645459-10	2020	LncRNA-OBFC2A, Smad3 and Cyclin D1 as a set of biomarkers play important roles in benzene haematotoxicity.	Benzene	82-89	cyclin D1	Homo sapiens	25-34
32721630-6	2020	Further studies found that CCT128930 triggered significant G-1 phase arrest and apoptosis, as convinced by the dysfunction of p27, Cyclin B1, Cyclin D1 and Cdc2, and PARP cleavage and caspase-3 activation.	4-(4-chlorobenzyl)-1-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)piperidin-4-amine	27-36	cyclin D1	Homo sapiens	142-151
32544514-6	2020	Mechanistically, quantitative proteomics and bioinformatics analyses, Western blotting and qRT-PCR confirmed that daurisoline exerted its anticancer effects by inhibiting the expression levels of beta-catenin and its downstream targets c-myc and cyclin D1.	daurisoline	114-125	cyclin D1	Homo sapiens	246-255
32945376-12	2020	In addition, AC significantly reduced the expression of CDK4 and Cyclin D1 in a dose-dependent manner, significantly upregulated the activation of caspase-9 and caspase-3, and decreased the Bcl-2/Bax mRNA ratio.	asiaticoside	13-15	cyclin D1	Homo sapiens	65-74
32567066-7	2020	CPF-exposed cells accumulated in S phase due to DNA damages while PILO + CPF imposed G0 stage arrest through cyclin D1 and P-Akt downregulation.	Pilocarpine	66-70	cyclin D1	Homo sapiens	109-118
33719271-8	2020	qRT-PCR and Western blot analysis showed that the mRNA and protein levels of cyclin D1 and cyclin B1 were significantly downregulated by BA at different concentrations(P<0.01).	Barium	137-139	cyclin D1	Homo sapiens	77-86
32945363-8	2020	In miR-483-3p-overexpressing human osteoblasts, cell viability, DNA synthesis capacity and osteogenesis were promoted, and the protein levels of Wnt1, beta-catenin and cyclin D1 were increased.	mir-483-3p	3-13	cyclin D1	Homo sapiens	168-177
33086930-7	2020	CONCLUSIONS: Non-cytotoxic naringin reduced the expression of beta-catenin, c-Myc, and cyclin D1 in SKOV3/CDDP cells and partially reversed cisplatin resistance in SKOV3/CDDP CN 20 cells.	naringin	27-35	cyclin D1	Homo sapiens	87-96
32945473-4	2020	Of note, the natural product xanthohumol (Xanth) inhibited NSCLC cells via the downregulation of cyclin D1.	xanthohumol	42-47	cyclin D1	Homo sapiens	97-106
32945504-7	2020	We also found that combined treatment of Rg3 and 5-FU significantly enhanced the apoptosis of colon cancer cells by activating the Apaf1/caspase 9/caspase 3 pathway and arrested the cell cycle of the colon cancer cells in G0/G1 by promoting the expression of Cyclin D1, CDK2 and CDK4.	ginsenoside Rg3	41-44	cyclin D1	Homo sapiens	259-268
33112552-1	2020	BACKGROUND: Cyclin D1 (CCND1) regulates cell cycle progression during the late G1 and S phase and takes part in methotrexate metabolism.	Methotrexate	112-124	cyclin D1	Homo sapiens	12-21
32945504-7	2020	We also found that combined treatment of Rg3 and 5-FU significantly enhanced the apoptosis of colon cancer cells by activating the Apaf1/caspase 9/caspase 3 pathway and arrested the cell cycle of the colon cancer cells in G0/G1 by promoting the expression of Cyclin D1, CDK2 and CDK4.	Fluorouracil	49-53	cyclin D1	Homo sapiens	259-268
33112552-1	2020	BACKGROUND: Cyclin D1 (CCND1) regulates cell cycle progression during the late G1 and S phase and takes part in methotrexate metabolism.	Methotrexate	112-124	cyclin D1	Homo sapiens	23-28
33112552-2	2020	It was hypothesized that CCND1 gene polymorphism affects acute lymphoblastic leukemia (ALL) development, prognosis and may relate to methotrexate cytotoxicity.	Methotrexate	133-145	cyclin D1	Homo sapiens	25-30
32634469-6	2020	In addition, 7-Epi reduced cyclin D1 and p-ERK expression levels in MCF-7 cell line.	7-epiclusianone	13-18	cyclin D1	Homo sapiens	27-36
33040777-6	2020	MDA-MB-231 cells were treated with cisatracurium of different concentrations for 48 h. CCK-8method detected cell proliferation, Transwell detected cell migration and invasion, Western Blot method detected the expression levels of CyclinD1, p21, MMP-2andMMP-9protein in cells, RT-qPCR) detected the expression level of miR-3174in cells.	cisatracurium	35-48	cyclin D1	Homo sapiens	230-238
33040777-8	2020	After different concentrations of Cisatracurium acted on MDA-MB-231 cells, the cell inhibition rate and p21 protein expression were significantly increased (p<0.05), the number of cell migration and invasion and the expression levels of CyclinD1, MMP-2 and MMP-9 were significantly reduced (p<0.05), and the expression of miR-3174 in cells was significantly reduced (p<0.05).	cisatracurium	34-47	cyclin D1	Homo sapiens	237-245
33029148-6	2020	The results showed that CTNNB1 and its target genes, including proto-oncogenes CCND1 and C-MYC, were aberrantly upregulated in hESCs after MMC treatment.	Mitomycin	139-142	cyclin D1	Homo sapiens	79-84
32645343-5	2020	Besides, BIBR1532 augmented ATO-induced cytotoxic effects via triggering G1 cell cycle arrest and induction of apoptosis coupled with the down-regulation of NF-kappaB target genes that were involved in cell cycle progression (e.g. CCND1 and CDK6) and prevention of apoptosis such as Bcl-2, Bcl-xl, c-IAP2, and Survivin Respectively.	BIBR 1532	9-17	cyclin D1	Homo sapiens	231-236
33072590-7	2020	Moreover, regorafenib suppressed palbociclib-induced expression of cyclin D1 contributing to the cytotoxic effects of the combination.	regorafenib	10-21	cyclin D1	Homo sapiens	67-76
33072590-7	2020	Moreover, regorafenib suppressed palbociclib-induced expression of cyclin D1 contributing to the cytotoxic effects of the combination.	palbociclib	33-44	cyclin D1	Homo sapiens	67-76
32645343-5	2020	Besides, BIBR1532 augmented ATO-induced cytotoxic effects via triggering G1 cell cycle arrest and induction of apoptosis coupled with the down-regulation of NF-kappaB target genes that were involved in cell cycle progression (e.g. CCND1 and CDK6) and prevention of apoptosis such as Bcl-2, Bcl-xl, c-IAP2, and Survivin Respectively.	Arsenic Trioxide	28-31	cyclin D1	Homo sapiens	231-236
32995296-0	2020	Autophagy regulates the Wnt/GSK3beta/beta-catenin/cyclin D1 pathway in mesenchymal stem cells (MSCs) exposed to titanium dioxide nanoparticles (TiO2NPs).	tio2nps	144-151	cyclin D1	Homo sapiens	50-59
32707053-10	2020	Similarly, rapamycin also significantly decreased the stimulatory effect of Rab31 on the expression of cyclin D1.	Sirolimus	11-20	cyclin D1	Homo sapiens	103-112
32574796-5	2020	miR-455-5p inhibition increased cell viability, PCNA, cyclin D1, and Bcl-2 levels and decreased apoptosis and Bax levels in SH-SY5Y neuroblastoma cells.	mir-455-5p	0-10	cyclin D1	Homo sapiens	54-63
32900227-11	2021	In conclusion, downregulations of protein expression of mutant p53, cyclin D1, mTOR, and beta-catenin were increased after both cell lines had been treated with pterostilbene.	pterostilbene	161-174	cyclin D1	Homo sapiens	68-77
32995296-6	2020	Our data shows that the exposure to TiO2NPs initiated autophagy, which led to an increase in extracellular Wnt protein levels and increased Wnt/GSK3beta/beta-catenin/cyclin D1 signalling in the cell population.	tio2nps	36-43	cyclin D1	Homo sapiens	166-175
32995296-9	2020	In conclusion, following exposure to TiO2NPs, MSCs undergo autophagy, which induces cell proliferation among the cell population by upregulation of cyclin D1 through the Wnt/GSK3beta/beta-catenin pathway.	tio2nps	37-44	cyclin D1	Homo sapiens	148-157
32810829-9	2020	Accordingly, GATA-4 inhibition via the small-molecule inhibitor NSC140905 restored miR-497~195 cluster expression, resulting in decreased viability, and Cyclin D1 downregulation.	2-(1,3-benzodioxol-5-ylmethyl)butanedioic acid	64-73	cyclin D1	Homo sapiens	153-162
31967380-10	2020	Alkannin counteracted the growth of PANC-1 cells through inhibiting proliferation, migration, and invasion and facilitating apoptosis, which was evidenced by the modulation on PCNA, CyclinD1, p53, and cleavage of caspases.	alkannin	0-8	cyclin D1	Homo sapiens	182-190
32765780-9	2020	Matrine treatment also promoted the expression of Bax and reduced the expression of Bcl-2 and cyclin D1 compared with the control.	matrine	0-7	cyclin D1	Homo sapiens	94-103
32558936-7	2020	Furthermore, we find that this cyclin D1 deficiency in ATRT results in marked in vitro and in vivo sensitivity to the CDK4/6 inhibitor palbociclib as a single agent.	palbociclib	135-146	cyclin D1	Homo sapiens	31-40
32716585-5	2020	miR-375-3p blocks the Wnt/beta-catenin pathway and downstream molecules Cyclin D1 and c-Myc by inhibiting the expression of FZD8 directly, it could increase caspase 1 and caspase 3 expression and promote T24 cell apoptosis as well.	mir-375-3p	0-10	cyclin D1	Homo sapiens	72-81
33277850-13	2020	Oridonin also targeted G2/M phase cell cycle in these gastric cancer cells along with targeting some key cell cycle related proteins including cyclin-B1, cyclin D1 and cyclin E. CONCLUSION: In conclusion, the results show that oridonin showed strong anticancer effects in SGC-7901 human gastric cancer cells by triggering apoptosis and autophagy, and targeting cell cycle at G2/M phase.	oridonin	0-8	cyclin D1	Homo sapiens	154-163
32909117-9	2020	shEPO treatment also significantly decreased the expression of cyclin D1 and increased the expression of p27kip1.	shepo	0-5	cyclin D1	Homo sapiens	63-72
32582967-13	2020	The changes in cyclin A and cyclin D1 expression was associated with cell cycle arrest upon alisol A treatment.	alisol A	92-100	cyclin D1	Homo sapiens	28-37
32606016-7	2020	Modulation of EZH2, Snail, eIF4E, IMPDH, mTOR, and cyclin D1 were observed in western blots and enzymatic activity assays in response to ribavirin treatment.	Ribavirin	137-146	cyclin D1	Homo sapiens	51-60
32872665-5	2020	In addition, CD treatment led to cell cycle arrest at the G0/G1 phase and inhibited expression of cyclin D1 and cyclin-dependent kinases 2 and 4 and led to increased levels of p21, p27Kip1 and p53.	Cadmium	13-15	cyclin D1	Homo sapiens	98-107
33164374-8	2020	Flavonoids of Sophorae Fructus significantly inhibited the proliferation, migration and invasion of Huh7 cells(P<0.05), promoted the expression of p21 protein(P<0.05), and inhibited the expressions of cyclinD1, MMP-2 and MMP-9(P<0.05) in a dose-dependent manner, and could reduce the activity of MMP-2 and MMP-9(P<0.05).	Flavonoids	0-10	cyclin D1	Homo sapiens	201-209
32904674-16	2020	WB detection showed that Carboplatin + LncRNA XIST intervention group could more significantly inhibit beta-catenin, cyclin B1, cyclin D1, N-cadherin, vimentin, Snail protein, and promote the up-regulation of Bax, Caspase-3, E-Cadherin and ZO-1 expression.	Carboplatin	25-36	cyclin D1	Homo sapiens	128-137
32792963-7	2020	Moreover, we found that the levels of p-RB, CDK4, and Cyclin D1 were up-regulated in sunitinib resistant 786-O, OS-RC-2, and TK-10 cells, and inhibition of CDK4 by palbociclib or wogonin effectively reversed the sunitinib resistance, indicating that the hyperactivation of CDK4-RB pathway may at least partially contribute to the resistance of RCC to sunitinib.	Sunitinib	85-94	cyclin D1	Homo sapiens	54-63
32945473-4	2020	Of note, the natural product xanthohumol (Xanth) inhibited NSCLC cells via the downregulation of cyclin D1.	xanthohumol	29-40	cyclin D1	Homo sapiens	97-106
32698579-5	2020	Specifically, the levels of the G1 phase-related markers cyclin D1 and cyclin E as well as the cycle dependent kinase 4, were suppressed by this particular ester.	Esters	156-161	cyclin D1	Homo sapiens	57-66
33015030-9	2020	Indeed, VPA impaired the transcription of genes induced by non-canonical activity of nuclear EGFR, such as cyclin D1 and thymidylate synthase.	Valproic Acid	8-11	cyclin D1	Homo sapiens	107-116
32505850-8	2020	Mechanistically, the expression of cyclin D1, an enhancer of the cell cycle, decreases, while p53, an inhibitor of cell proliferation, was up-regulated upon the treatment with compound 6 alone or in combination with the chemotherapeutic agent doxorubicin.	Doxorubicin	243-254	cyclin D1	Homo sapiens	35-44
32913511-7	2020	In vitro, SCLC cell line treated with Fasudil exhibited synapse-like morphologic change, accompanied by a reduction in the expression levels of c-myc and cyclin D1.	fasudil	38-45	cyclin D1	Homo sapiens	154-163
32944401-13	2020	GSK3beta then mediates phosphorylation of Cyclin D1 at threonine 286, thereby promoting the translocation of Cyclin D1 from the nucleus to the cytoplasm and facilitating Cyclin D1 degradation through the ubiquitin-proteasome system.	Threonine	55-64	cyclin D1	Homo sapiens	42-51
32944401-13	2020	GSK3beta then mediates phosphorylation of Cyclin D1 at threonine 286, thereby promoting the translocation of Cyclin D1 from the nucleus to the cytoplasm and facilitating Cyclin D1 degradation through the ubiquitin-proteasome system.	Threonine	55-64	cyclin D1	Homo sapiens	109-118
32944401-13	2020	GSK3beta then mediates phosphorylation of Cyclin D1 at threonine 286, thereby promoting the translocation of Cyclin D1 from the nucleus to the cytoplasm and facilitating Cyclin D1 degradation through the ubiquitin-proteasome system.	Threonine	55-64	cyclin D1	Homo sapiens	109-118
32792481-0	2020	PLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance.	palbociclib	109-120	cyclin D1	Homo sapiens	57-62
32850849-10	2020	In vitro studies showed increased expression of osteogenic markers (BMP2 and miRNA-223-3p), expression of cyclin D1, beta-galactosidase activity and VSMC size in those cells treated with txMV.	txmv	187-191	cyclin D1	Homo sapiens	106-115
32505819-7	2020	RESULTS: The current study shows that, Notch signaling downregulation (Hes1 and CyclinD1 genes), caused by 6-shogaol, lead to antiproliferative activity in breast cancer cells.	shogaol	107-116	cyclin D1	Homo sapiens	80-88
32535106-5	2020	Cyclin D1/CDK4/6 inhibition resensitizes erlotinib-resistant (ER) cells to erlotinib.	Erlotinib Hydrochloride	41-50	cyclin D1	Homo sapiens	0-9
32535106-5	2020	Cyclin D1/CDK4/6 inhibition resensitizes erlotinib-resistant (ER) cells to erlotinib.	Erlotinib Hydrochloride	75-84	cyclin D1	Homo sapiens	0-9
32915362-11	2020	The increase in berberine concentration led to an increase in miRNA-582-5p and miRNA-188-5p expression and a decrease in the expression of mRNA for the corresponding target genes encoding CDK1, CDK2, and cyclins D1 and A.	Berberine	16-25	cyclin D1	Homo sapiens	204-220
32898333-5	2020	RESULTS: Dysregulation of CCND1-CDK4/6-Rb axis might be the key to pyrotinib refractory.	pyrotinib	67-76	cyclin D1	Homo sapiens	26-31
32765662-10	2020	Additionally, the expression of phosphorylated (p)-AKT and p-mTOR, P70 and cyclin D1 were decreased in U251 and U81 cells following prazosin treatment (P<0.05).	Prazosin	132-140	cyclin D1	Homo sapiens	75-84
32626954-8	2020	The results indicated that paeonol exhibited a notable effect against HCT116 cells by inducing G0/G1-phase arrest, as demonstrated by downregulation of the cell cycle regulators cyclin-dependent kinase 4 and cyclin D1 and upregulation of p21Cip1 in a dose-dependent manner.	paeonol	27-34	cyclin D1	Homo sapiens	208-217
32626954-10	2020	Paeonol also dose-dependently blocked the activation of the Wnt/beta-catenin signaling pathway by suppressing the expression of beta-catenin, resulting in a decrease in beta-catenin-mediated activity of TCF/LEF and downregulation of downstream target genes, including cyclin D1, survivin and c-Myc.	paeonol	0-7	cyclin D1	Homo sapiens	268-277
32227673-3	2020	Treatment with tomentosin (IC50  = 20 microM) significantly inhibited cell proliferation and oxidative stress-induced anti-cell proliferative (proliferating cell nuclear antigen and cyclin-D1) also regulated expression, drastically diminished tumor necrosis factor-alpha, nuclear factor-kappaB, interleukin-6, and interleukin-1beta expression levels, significantly upregulated Bcl-2 and Bax expression.	tomentosin	15-25	cyclin D1	Homo sapiens	182-191
32302969-8	2020	Real-time PCR and western blotting demonstrated that 10-3 M NaI increased p21, p27, and p57 levels and reduced cyclin D1 levels in PTC cells.	nai	60-63	cyclin D1	Homo sapiens	111-120
32388163-4	2020	Fucoidan treatment decreased the expression of beta-catenin C-Myc, CyclinD1 and Survivin, while the Hippo pathway was activated with increased phosphorylation levels of mammalian sterile 20-like kinase 1 and 2, large tumor suppressor 1 and 2, and Yes-associated protein.	fucoidan	0-8	cyclin D1	Homo sapiens	67-75
32626956-11	2020	In addition, the curcumin-induced decreased expression levels of beta-catenin, cyclin D1 and c-Myc were rescued following the genetic knockdown of miR-192-5p.	Curcumin	17-25	cyclin D1	Homo sapiens	79-88
32626983-4	2020	Telmisartan and candesartan inhibited the proliferation of these cells by blocking the G0 to G1 cell cycle transition, which was accompanied by a decrease in cell cycle-related proteins such as cyclin D1.	Telmisartan	0-11	cyclin D1	Homo sapiens	194-203
32626983-4	2020	Telmisartan and candesartan inhibited the proliferation of these cells by blocking the G0 to G1 cell cycle transition, which was accompanied by a decrease in cell cycle-related proteins such as cyclin D1.	candesartan	16-27	cyclin D1	Homo sapiens	194-203
32428595-0	2020	Corrigendum to "Sesamin suppresses NSCLC cell proliferation through cyclin D1 inhibition-dependent cell cycle arrest via Akt/p53 pathway" [Toxicology and applied pharmacology, 387 (2020) 114848].	sesamin	16-23	cyclin D1	Homo sapiens	68-77
32798398-7	2020	Compared with single-drug treatment group, DAC combined with BTZ significantly increased the inhibitory rate and apoptotic rate of Jeko-1 and Grante519 cells; PCDH8, Caspase 3 and BAX expression levels significantly increased, and the expression levels of NF-kappaB, BCL-2 and CCND1 significantly decreased in Jeko-1 and Grante519 cells.	Decitabine	43-46	cyclin D1	Homo sapiens	277-282
32798398-7	2020	Compared with single-drug treatment group, DAC combined with BTZ significantly increased the inhibitory rate and apoptotic rate of Jeko-1 and Grante519 cells; PCDH8, Caspase 3 and BAX expression levels significantly increased, and the expression levels of NF-kappaB, BCL-2 and CCND1 significantly decreased in Jeko-1 and Grante519 cells.	btz	61-64	cyclin D1	Homo sapiens	277-282
32722075-11	2020	The results suggested that the synergistic cytotoxic effect of LY and TAM is achieved by the induction of apoptosis and cell cycle arrest through cyclin D1, pAKT, caspases, and Bcl-2 signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-65	cyclin D1	Homo sapiens	146-155
32722075-11	2020	The results suggested that the synergistic cytotoxic effect of LY and TAM is achieved by the induction of apoptosis and cell cycle arrest through cyclin D1, pAKT, caspases, and Bcl-2 signaling pathways.	Tamoxifen	70-73	cyclin D1	Homo sapiens	146-155
32792963-7	2020	Moreover, we found that the levels of p-RB, CDK4, and Cyclin D1 were up-regulated in sunitinib resistant 786-O, OS-RC-2, and TK-10 cells, and inhibition of CDK4 by palbociclib or wogonin effectively reversed the sunitinib resistance, indicating that the hyperactivation of CDK4-RB pathway may at least partially contribute to the resistance of RCC to sunitinib.	wogonin	179-186	cyclin D1	Homo sapiens	54-63
32792963-7	2020	Moreover, we found that the levels of p-RB, CDK4, and Cyclin D1 were up-regulated in sunitinib resistant 786-O, OS-RC-2, and TK-10 cells, and inhibition of CDK4 by palbociclib or wogonin effectively reversed the sunitinib resistance, indicating that the hyperactivation of CDK4-RB pathway may at least partially contribute to the resistance of RCC to sunitinib.	Sunitinib	212-221	cyclin D1	Homo sapiens	54-63
32792963-7	2020	Moreover, we found that the levels of p-RB, CDK4, and Cyclin D1 were up-regulated in sunitinib resistant 786-O, OS-RC-2, and TK-10 cells, and inhibition of CDK4 by palbociclib or wogonin effectively reversed the sunitinib resistance, indicating that the hyperactivation of CDK4-RB pathway may at least partially contribute to the resistance of RCC to sunitinib.	Sunitinib	212-221	cyclin D1	Homo sapiens	54-63
32708030-10	2020	Calebin A also suppressed the expression of NF-kappaB-promoted anti-apoptotic (Bcl-2, Bcl-xL, survivin), proliferation (Cyclin D1), invasion (MMP-9), metastasis (CXCR4), and down-regulated apoptosis (Caspase-3) gene biomarkers, leading to apoptosis in HCT116 cells.	calebin-A	0-9	cyclin D1	Homo sapiens	120-129
32631996-7	2020	Hepatocyte cyclin D1 gene ablation caused markedly increased postprandial liver glycogen levels (in a HNF4alpha-dependent fashion), indicating that the cyclin D1-HNF4alpha axis regulates glucose metabolism in response to feeding.	Glycogen	80-88	cyclin D1	Homo sapiens	11-20
32631996-7	2020	Hepatocyte cyclin D1 gene ablation caused markedly increased postprandial liver glycogen levels (in a HNF4alpha-dependent fashion), indicating that the cyclin D1-HNF4alpha axis regulates glucose metabolism in response to feeding.	Glycogen	80-88	cyclin D1	Homo sapiens	152-171
32631996-8	2020	In AML12 hepatocytes, cyclin D1 depletion led to increased glucose uptake, which was negated if HNF4alpha was depleted simultaneously, and markedly elevated glycogen synthesis.	Glucose	59-66	cyclin D1	Homo sapiens	22-31
32631996-8	2020	In AML12 hepatocytes, cyclin D1 depletion led to increased glucose uptake, which was negated if HNF4alpha was depleted simultaneously, and markedly elevated glycogen synthesis.	Glycogen	157-165	cyclin D1	Homo sapiens	22-31
32220884-8	2020	We identified two mechanisms of acquired resistance to AZD5363: cyclin D1 overexpression and loss of AKT1 p.E17K.	capivasertib	55-62	cyclin D1	Homo sapiens	64-73
32648126-8	2022	After treated with KAI for 48 h, the proportion of G1 phase was increased, expression level of cyclin D1 and phosphorylation-RB were down-regulated, whereas the expression of p21 was up-regulated (all P<0.01).	Kainic Acid	19-22	cyclin D1	Homo sapiens	95-104
32304943-6	2020	In addition, TDCPP induced cell apoptosis and arrested cell cycle in the G0/G1 phase at 16 and 160 mug/mL by enhancing Bax and Caspase-3 expression besides inhibiting cyclin D1, CDK2, CDK6 and Bcl-2 expression.	tris(1,3-dichloro-2-propyl)phosphate	13-18	cyclin D1	Homo sapiens	167-176
31646340-3	2020	Similar to estrogens, exposure of ovariectomized animals to arsenite induced the expression of the progesterone receptor, GREB1, and c-fos in the mammary gland and the expression of complement C3, c-fos, and cyclin D1 in the uterus and the increase was blocked by the antiestrogen ICI-182,780.	Arsenites	60-68	cyclin D1	Homo sapiens	208-217
32644826-0	2021	Pulsed and Discontinuous Electromagnetic Field Exposure Decreases Temozolomide Resistance in Glioblastoma by Modulating the Expression of O6-Methylguanine-DNA Methyltransferase, Cyclin-D1, and p53.	Temozolomide	66-78	cyclin D1	Homo sapiens	178-187
32650495-8	2020	Mambalgin-2 induced a cell cycle arrest, inhibited Cyclin D1 and cyclin-dependent kinases (CDK) phosphorylation and caused apoptosis in U251 MG and A172 cells.	mambalgin-2	0-11	cyclin D1	Homo sapiens	51-60
32404543-4	2020	Latifolin reversed the senescence-like phenotypes of the oxidant-challenged model, including senescence-associated beta-galactosidase (SA-beta-gal) staining, cell proliferation, and the expression of senescence-related proteins, such as caveolin-1, ac-p53, p21Cip1/WAF1, p16Ink4alpha, pRb, and cyclinD1.	latifolin	0-9	cyclin D1	Homo sapiens	294-302
32044796-9	2020	The combination of C61-LNP and CDDP changed in alterations of the cell cycle regulatory proteins p53, p21, p27, cyclin D1 and cyclin E levels.	AT 61	19-22	cyclin D1	Homo sapiens	112-121
32044796-9	2020	The combination of C61-LNP and CDDP changed in alterations of the cell cycle regulatory proteins p53, p21, p27, cyclin D1 and cyclin E levels.	Cisplatin	31-35	cyclin D1	Homo sapiens	112-121
32394669-4	2020	Vanillic acid promoted the proliferation of DPCs, accompanied by increased levels of cell-cycle proteins cyclin D1, CDK6, and Cdc2 p34.	Vanillic Acid	0-13	cyclin D1	Homo sapiens	105-114
32394669-9	2020	We found that vanillic acid increased the levels of cyclin D1 and Cox-2, which are target genes of beta-catenin, and these changes were inhibited by wortmannin.	Vanillic Acid	14-27	cyclin D1	Homo sapiens	52-61
32394669-9	2020	We found that vanillic acid increased the levels of cyclin D1 and Cox-2, which are target genes of beta-catenin, and these changes were inhibited by wortmannin.	Wortmannin	149-159	cyclin D1	Homo sapiens	52-61
32377705-9	2020	Further studies revealed the mechanism underlying this cooperative antiproliferative effect involved to be due to the prohibitive effects of HSulf-1 on the palbociclib-induced accumulation of cyclin D1 through AKT/STAT3 and ERK1/2/STAT3 signaling.	palbociclib	156-167	cyclin D1	Homo sapiens	192-201
31529026-8	2020	Using protein expression analysis along with luciferase assays, we found that extracellular cAMP acts via the A2R/PKA/CREB/p53/Cyclin D1 pathway.	Cyclic AMP	92-96	cyclin D1	Homo sapiens	127-136
31647312-11	2020	Hub mRNAs, including CYCS, CCND1, BDKRB, ITGA6, and TNNC1, were mainly enriched in cancer pathways, p53 signaling pathway, and calcium signaling pathway.	Calcium	127-134	cyclin D1	Homo sapiens	27-32
32542982-6	2020	In human airway smooth muscle cells (HASMCs), dabigatran not only alleviated thrombin-induced proliferation, migration and up-regulation of collagen I, alpha-SMA, CTGF and cyclin D1, but also inhibited thrombin-induced YAP activation, while YAP activation mediated thrombin-induced HASMCs remodeling.	Dabigatran	46-56	cyclin D1	Homo sapiens	172-181
32418739-0	2020	CCND1 silencing suppresses liver cancer stem cell differentiation and overcomes 5-Fluorouracil resistance in hepatocellular carcinoma.	Fluorouracil	80-94	cyclin D1	Homo sapiens	0-5
32418739-5	2020	Herein, this study was designed to explore the role of CCND1 in regulating LCSCs differentiation and 5-Fu resistance in HCC cells.	Fluorouracil	101-105	cyclin D1	Homo sapiens	55-60
32418739-10	2020	Furthermore, CCND1 silencing significantly increased protein level of gamma-H2AX and decreased that of RAD51 under 5-Fu exposure.	Fluorouracil	115-119	cyclin D1	Homo sapiens	13-18
32418739-11	2020	Moreover, CCND1 silencing enhanced the sensitivity of HepG2 and SMMC-7721 cells to 5-Fu, which was effectively abrogated by RAD51 upregulation.	Fluorouracil	83-87	cyclin D1	Homo sapiens	10-15
32418739-12	2020	CONCLUSION: Collectively, CCND1 silencing suppresses LCSCs differentiation and overcomes 5-Fu resistance in HCC.	Fluorouracil	89-93	cyclin D1	Homo sapiens	26-31
32566002-6	2020	Furthermore, it was demonstrated that the downregulation of miR-181a inhibited the expression of CCND1, a cell cycle regulatory gene, and caused cell cycle arrest in MM cells.	mir-181a	60-68	cyclin D1	Homo sapiens	97-102
32377708-13	2020	DHC inhibited the production of proliferation- and anti-apoptosis-associated proteins CDK1, CCND1, BCL2 as well as that of the metastasis-associated proteins MMP2 and MMP9.	dehydrocorydalin	0-3	cyclin D1	Homo sapiens	92-97
32377708-16	2020	DHC exerted anticancer effects by downregulating cell proliferation, antiapoptosis, metastasis-associated proteins CDK1, CCND1, BCL2 and metastasis-associated proteins MMP2 and MMP9, and by upregulating the expression of proapoptotic proteins caspase 3/8/9.	dehydrocorydalin	0-3	cyclin D1	Homo sapiens	121-126
32565961-11	2020	Overall, the findings of the present study suggest that DMY inhibits the proliferation of human choriocarcinoma JAR cells, potentially through cell cycle arrest via the downregulation of cyclin A1, cyclin D1, SMAD3 and SMAD4 expression levels.	dihydromyricetin	56-59	cyclin D1	Homo sapiens	198-207
32373927-7	2020	MiR-377-3p was observed to significantly inhibit ox-LDL-induced VSMC proliferation characterized by inhibited cell viability, expressions of proliferating cell nuclear antigen (PCNA), cyclin D1 and cyclin E and cell cycle transition from G1 to S phase accompanied with less 5-Ethynyl-2"-deoxyuridine (EdU)-positive cells.	mir-377-3p	0-10	cyclin D1	Homo sapiens	184-193
32551032-11	2020	The western blot analysis revealed that nitroxoline or bortezomib treatment markedly diminished the levels of Bcl-2 and cyclin D1, and increased the levels of p21, Bax, cleaved PARP and cleaved caspase-3.	nitroxoline	40-51	cyclin D1	Homo sapiens	120-129
32307979-6	2020	Subgroup analysis showed that the levels of beta-catenin, cyclinD1 and c-myc in the high-dose (>5muM) arsenic intervention group were lower than those in the control group, and the levels of beta-catenin and cyclinD1 in the high-dose (>5muM) arsenic intervention group were lower than those in the low-dose (<=5muM) arsenic intervention group (P<0.05, respectively).	Arsenic	102-109	cyclin D1	Homo sapiens	58-66
32307979-6	2020	Subgroup analysis showed that the levels of beta-catenin, cyclinD1 and c-myc in the high-dose (>5muM) arsenic intervention group were lower than those in the control group, and the levels of beta-catenin and cyclinD1 in the high-dose (>5muM) arsenic intervention group were lower than those in the low-dose (<=5muM) arsenic intervention group (P<0.05, respectively).	Arsenic	102-109	cyclin D1	Homo sapiens	208-216
32551032-11	2020	The western blot analysis revealed that nitroxoline or bortezomib treatment markedly diminished the levels of Bcl-2 and cyclin D1, and increased the levels of p21, Bax, cleaved PARP and cleaved caspase-3.	Bortezomib	55-65	cyclin D1	Homo sapiens	120-129
32486604-9	2020	Overexpression of miR-16-5p obviously reduced the expression of CyclinD1, MMP-2, MMP-9 protein, cell viability, cell migration and invasion (F=150.136,117.228, 154.971, 89.479, 98.373, 130.880, all P<0.05) in MG63 cells.	mir-16-5p	18-27	cyclin D1	Homo sapiens	64-72
32486604-13	2020	High expression of TSPAN15 partially reversed the inhibitory effect of miR-16-5p on TSPAN15, CyclinD1, MMP-2, MMP-9, p-PI3K, p-AKT protein expression, cell viability, cell migration number and invasion number in MG63 cells.	mir-16-5p	71-80	cyclin D1	Homo sapiens	93-101
32145588-5	2020	Fluoxetine obviously decreased expression of cell proliferative, anti-apoptotic, invasion-associated proteins including Cyclin-D1, survivin, vascular endothelial growth factor (VEGF), matrix metallopeptidase 9 (MMP-9) and urokinase-type plasminogen activator (uPA).	Fluoxetine	0-10	cyclin D1	Homo sapiens	120-129
31955140-0	2020	SOX7 is involved in polyphyllin D-induced G0/G1 cell cycle arrest through down-regulation of cyclin D1.	polyphyllin D	20-33	cyclin D1	Homo sapiens	93-102
32633363-10	2020	Meanwhile, simvastatin treatment caused cell cycle arrest in G0/G1 phase, remarkably downregulated expression of cyclin D1, and upregulated expressions of p21 and Bim.	Simvastatin	11-22	cyclin D1	Homo sapiens	113-122
32130660-11	2020	After treatment with si-LINC01234 or miR-193a-5p mimic, EC cells (Eca-109 and EC9706) exhibited cyclinD1 and Bcl-2 downregulation, and caspase-3, p21, Bax and cleaved caspase-3 upregulation.	Silicon	21-23	cyclin D1	Homo sapiens	96-104
32472755-5	2020	Overexpression of miR-139-5p in OSCC inhibited in vitro and in vivo cell proliferation and in vitro mobility of OSCC and inhibited the expression of WNT responsive c-myc, cyclinD1, and Bcl-2, and such effects were all reversible by an inhibitor of miR-139-5p or over-expression of CXCR4.	mir-139-5p	18-28	cyclin D1	Homo sapiens	171-179
32236634-3	2020	HS-146 was found to be most effective in inhibiting the proliferation of MCF-7 cells and in inducing cell cycle arrest in the G0/G1 phase by downregulating cyclin D1, cyclin E, cyclin-dependent kinase (Cdk)2 and Cdk4, and upregulating p21Waf1/Cip1 protein levels in this cell line.	hs-146	0-6	cyclin D1	Homo sapiens	156-165
32347651-6	2020	Pristimerin inhibited Akt and FoxO3a phosphorylation and induced nuclear accumulation of FoxO3a in UM-1 cells, increased the expression of pro-apoptotic proteins Bim p27Kip1 , cleaved caspase-3, PARP and Bax, and decreased the expression of Cyclin D1 and Bcl-2.	pristimerin	0-11	cyclin D1	Homo sapiens	241-250
32267554-4	2020	In addition, oleanolic acid was the dominant compound act on the Bel-7402 cells in the extract and it induced apoptosis by the caspase pathway and induced cell cycle arrest at the G0/G1 phase by inhibiting the cyclin D1/CDK4 pathway.	Oleanolic Acid	13-27	cyclin D1	Homo sapiens	210-219
31971313-5	2020	alpha-Conidendrin remarkably inhibited the proliferation of breast cancer cells through induction of cell cycle arrest by upregulating p53 and p21 and downregulating cyclin D1 and CDK4.	conidendrin	0-17	cyclin D1	Homo sapiens	166-175
33043343-8	2020	Inhibition of NEAT1 or over-expression of miR-339-5p significantly inhibited proliferation, migration and invasion of CAL27 cells, and significantly inhibited expression of Cyclin D1 and MMP-9 proteins.	mir-339-5p	42-52	cyclin D1	Homo sapiens	173-182
32268137-9	2020	At the molecular level, CHF6001 inhibited translocation of phosphorylated NF-kappaB subunit p65, promoting loss of nuclear cyclin D1 accumulation and an increase of cell cycle inhibitor p21.	3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3-(cyclopropylmethoxy)-4-(methylsulfonamido)benzoyloxy)ethyl)pyridine 1-oxide	24-31	cyclin D1	Homo sapiens	123-132
31975484-5	2020	The combination of these agents also more efficiently reduced major molecular drivers of BC proliferation in the tamoxifen-resistant cells, including c-Myc, cyclin D1 and p-AKT, while up-regulating the cell cycle inhibitor, p27, and inhibiting oncogenic phosphorylation of ER-alpha at Ser167.	Tamoxifen	113-122	cyclin D1	Homo sapiens	157-166
32509787-9	2020	Xanthohumol also induced apoptosis and cell cycle arrest at G1 phase which was associated with the modulation of expression of related makers including cyclin D1, cyclin D3, and cleaved-PARP, Bcl-2, cytochrome c and Bax.	xanthohumol	0-11	cyclin D1	Homo sapiens	152-161
32429557-6	2020	In all cell lines, combination indexes documented synergistic interaction of SHetA2 and palbociclib in association SHetA2 reduction of cyclin D1 and phospho-Rb, palbociclib reduction of phospho-Rb, and enhanced phospho-Rb reduction upon drug combination.	palbociclib	88-99	cyclin D1	Homo sapiens	135-144
32393760-8	2020	We further verified the upregulation of beta-catenin and cyclin D1 induced by circ5615.	circ5615	78-86	cyclin D1	Homo sapiens	57-66
32440158-9	2020	In vitro, AURKA knockdown significantly reduced the viability of HuH-6 cells, while ALS treatment significantly suppressed HuH-6 cell proliferation and induced G1-phase cell cycle arrest by reducing cyclin-D1 expression.	MLN 8237	84-87	cyclin D1	Homo sapiens	199-208
32371868-7	2020	I-BET726 not only downregulated BRD4-regulated proteins (c-Myc, Bcl-2, and cyclin D1), but also inhibited sphingosine kinase 1 (SphK1) and Akt signalings in SCC cells.	4-(1-acetyl-4-((4-chlorophenyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoic acid	0-8	cyclin D1	Homo sapiens	75-84
32198408-7	2020	A significant positive correlation was found between Cyclin D1 expression and the cumulative dose of radioactive iodine received by patients (r = -0.2, p value = 0.03).	radioactive iodine	101-119	cyclin D1	Homo sapiens	53-62
32062191-3	2020	Here we found that rapamycin inhibited human soluble BAFF (hsBAFF)-stimulated cell proliferation by inducing G1-cell cycle arrest, which was through downregulating the protein levels of CDK2, CDK4, CDK6, cyclin A, cyclin D1, and cyclin E. Rapamycin reduced hsBAFF-stimulated cell survival by downregulating the levels of anti-apoptotic proteins (Mcl-1, Bcl-2, Bcl-xL and survivin) and meanwhile upregulating the levels of pro-apoptotic proteins (BAK and BAX).	Sirolimus	19-28	cyclin D1	Homo sapiens	214-223
32432757-0	2020	TUG1 weakens the sensitivity of acute myeloid leukemia cells to cytarabine by regulating miR-655-3p/CCND1 axis.	Cytarabine	64-74	cyclin D1	Homo sapiens	100-105
32432757-10	2020	MiR-655-3p directly targeted CCND1, and CCND1 overexpression attenuated miR-655-3p restoration-mediated reinforcement of Ara-C sensitivity in AML cells.	mir-655-3p	0-10	cyclin D1	Homo sapiens	29-34
32691575-9	2020	Meanwhile, Baicalein treatment downregulated CyclinD1 and CDK4, while upregulating P53 and P21.	baicalein	11-20	cyclin D1	Homo sapiens	45-53
32009586-5	2020	LCC induced G1 arrest accompanied by decreased cyclin D1 expression and an increase in the levels of p21 and p27.	licochalcone A	0-3	cyclin D1	Homo sapiens	47-56
32323769-5	2020	The miR-296-3p antagonist altered the expression of a number of key genes that are involved in cell cycle control, including cyclin D1 and p21.	mir-296-3p	4-14	cyclin D1	Homo sapiens	125-134
32425601-14	2020	Subsequently, EVO induced cell cycle arrest at the G2/M phase that correlated with reduced levels of cyclin D1 protein, while the apoptotic effects of EVO were associated with the upregulation of Bax and Bad and a decrease in Bcl-2 protein levels.	evodiamine	14-17	cyclin D1	Homo sapiens	101-110
32425599-8	2020	GA treatment down-regulated the levels of G1 phase-related proteins, including cyclin D1, D2, D3, E1, and E2.	Glycyrrhizic Acid	0-2	cyclin D1	Homo sapiens	79-108
32260268-4	2020	8-Hydroxyquinaldic acid induced changes in protein expression of cell cycle regulators (CDK4, CDK6, cyclin D1, cyclin E) and CDKs inhibitors (p21 Waf1/Cip1, p27 Kip1), but the effect was dependent on the tested cell line.	8-hydroxyquinoline-2-carboxylic acid	0-23	cyclin D1	Homo sapiens	100-109
32742733-7	2020	In the K562 cells, mambalgin-2 caused arrest of the cell cycle in the G1 phase and reduced the phosphorylation of G1 cell cycle phase regulators: cyclin D1 and cyclin-dependent kinase CDK4, without affecting the activity of CDK6 kinase.	mambalgin-2	19-30	cyclin D1	Homo sapiens	146-155
31986415-13	2020	MIF-induced increase in cyclin D1 mRNA level also was inhibited only by U0126 following MIF stimulation.	U 0126	72-77	cyclin D1	Homo sapiens	24-33
31543512-7	2020	After cell treatment by 5-AZA, the genetic expression of SOX17 significantly increased, when compared with that before treatment (P < 0.05), while the genetic expression of beta-catenin and CyclinD1 significantly declined (P < 0.05).	Azacitidine	24-29	cyclin D1	Homo sapiens	190-198
32307979-3	2020	We found that in normal cells, the levels of wnt3a, beta-catenin, glycogen synthase kinase-3beta phosphorylated at serine 9 (p-GSK-3beta(Ser9)), cyclinD1, proto-oncogene c-myc and vascular endothelial growth factor (VEGF) in arsenic intervention group were higher than those in control group, and the level of glycogen synthase kinase-3beta (GSK-3beta) was lower than that in control group (P<0.05, respectively).	Serine	115-121	cyclin D1	Homo sapiens	145-175
32432757-10	2020	MiR-655-3p directly targeted CCND1, and CCND1 overexpression attenuated miR-655-3p restoration-mediated reinforcement of Ara-C sensitivity in AML cells.	mir-655-3p	72-82	cyclin D1	Homo sapiens	40-45
32432757-10	2020	MiR-655-3p directly targeted CCND1, and CCND1 overexpression attenuated miR-655-3p restoration-mediated reinforcement of Ara-C sensitivity in AML cells.	Cytarabine	121-126	cyclin D1	Homo sapiens	40-45
32432757-12	2020	CONCLUSIONS: TUG1 weakened the sensitivity of AML cells to Ara-C by up-regulating CCND1 via miR-655-3p, suggesting a new insight into the chemotherapy of AML.	Cytarabine	59-64	cyclin D1	Homo sapiens	82-87
31960917-7	2020	Quercetin down-regulated p53, Bax and cleaved-caspase-3 expression, while up-regulated CyclinD1, CDK4 and Bcl-2.	Quercetin	0-9	cyclin D1	Homo sapiens	87-95
32323807-6	2020	In addition, alpha-solanine arrested the cell cycle at the G0/G1 phase and suppressed the expression levels of cyclin D1 and cyclin-dependent kinase 2 in RKO cells.	alpha-solanine	13-27	cyclin D1	Homo sapiens	111-120
32431514-9	2020	Moreover, combination of TET and PTX obviously induced cell cycle arrest in SKOV3/PTX cells via increasing the level of p21 and decreasing the levels of c-Myc and Cyclin D1.	tetrandrine	25-28	cyclin D1	Homo sapiens	163-172
32431514-9	2020	Moreover, combination of TET and PTX obviously induced cell cycle arrest in SKOV3/PTX cells via increasing the level of p21 and decreasing the levels of c-Myc and Cyclin D1.	Paclitaxel	33-36	cyclin D1	Homo sapiens	163-172
32431514-12	2020	Conclusion: We found that TET could enhance the sensitivity of SKOV3/PTX cells to PTX via inhibiting the beta-catenin/c-Myc/Cyclin D1 signaling pathway.	tetrandrine	26-29	cyclin D1	Homo sapiens	124-133
32431514-12	2020	Conclusion: We found that TET could enhance the sensitivity of SKOV3/PTX cells to PTX via inhibiting the beta-catenin/c-Myc/Cyclin D1 signaling pathway.	Paclitaxel	69-72	cyclin D1	Homo sapiens	124-133
32431514-12	2020	Conclusion: We found that TET could enhance the sensitivity of SKOV3/PTX cells to PTX via inhibiting the beta-catenin/c-Myc/Cyclin D1 signaling pathway.	Paclitaxel	82-85	cyclin D1	Homo sapiens	124-133
32368152-7	2020	Furthermore, psoralen reversed miR-196a-5p-induced DDP resistance and reduced the expression levels of HOXB7, HER2, Bcl-2 and CCND1.	Ficusin	13-21	cyclin D1	Homo sapiens	126-131
32036474-4	2020	Western blot analysis with an antibody to gammaH2AX showed that DS00329 induced DNA damage and flow cytometry and western blotting confirmed that it triggered a G1 cell cycle arrest which correlated with decreased levels in Cyclin A, Cyclin B, Cyclin D1 and cyclin dependent kinase 2 and an increase in levels of the cyclin dependent kinase inhibitor p21.	ds00329	64-71	cyclin D1	Homo sapiens	244-253
31972361-0	2020	Long noncoding RNA LINC00461 mediates cisplatin resistance of rectal cancer via miR-593-5p/CCND1 axis.	Cisplatin	38-47	cyclin D1	Homo sapiens	91-96
31972361-9	2020	Furthermore, CCND1 upregulation could reverse the effect of LINC00461 downregulation on rectal cancer progression and cisplatin resistance of rectal cancer.	Cisplatin	118-127	cyclin D1	Homo sapiens	13-18
31972361-10	2020	To sum up, LINC00461 mediates cisplatin resistance of rectal cancer by targeting miR-593-5p/CCND1 axis, shedding new light on the treatment of rectal cancer.	Cisplatin	30-39	cyclin D1	Homo sapiens	92-97
32332626-5	2020	In addition, Bicalutamide could significantly induce the cell cycle arrest at G0/G1 phase and decrease the protein expression of AR, cyclin D1, matrix metalloprotease-2 (MMP-2), and matrix metalloprotease-9 (MMP-9).The present study indicated the Bicalutamide inhibited the proliferation and invasion process of triple negative breast cancer cells by targeting AR signaling pathway and down-regulating MMP-2/-9 protein expression levels.	bicalutamide	13-25	cyclin D1	Homo sapiens	133-142
31782192-4	2020	Further, we found capsaicin suppressed the expression of Wnt-2, p-GSK3beta and beta-catenin, along with downregulation of Wnt/beta-catenin pathway target genes c-myc and cyclinD1.	Capsaicin	18-27	cyclin D1	Homo sapiens	170-178
32113150-12	2020	Furthermore, beta-EA induced G0/G1 cell cycle arrest and inhibited metastasis of HOS and 143B cells by attenuating Wnt/beta-catenin signaling effects, which included decreased levels of p-Akt(Ser473), p-Gsk3beta (Ser9), Wnt/beta-catenin target genes (c-Myc and CyclinD1) along with a decline in nuclear beta-catenin accumulation.	beta-ea	13-20	cyclin D1	Homo sapiens	261-269
32219038-9	2020	At molecular levels, cell cycle regulators cyclin D1, CDK4, CDK6, p21 and p53 were modulated in response to treatment with ICA.	icariin	123-126	cyclin D1	Homo sapiens	43-52
32219038-11	2020	Further mechanical explorations showed that H19 knockdown resulted in alternative expressions levels of cyclin D1, CDK4, CDK6, p21 and p53 under ICA treatment.	icariin	145-148	cyclin D1	Homo sapiens	104-113
32231574-6	2020	In this study, we found that nintedanib attenuated myofibroblast activation through inhibiting the expression of genes downstream of Wnt signaling such as Cyclin D1, Wisp1, and S100a4.	nintedanib	29-39	cyclin D1	Homo sapiens	155-164
32170185-4	2020	Western blot analysis showed the degradation of cyclin D1 and CDK4, and an increase in the expression levels of p21 and p27 after TZDs treatment.	Thiazolidinediones	130-134	cyclin D1	Homo sapiens	48-57
32183146-5	2020	Then, we noted that EVO arrested the cell cycle, caused apoptosis, and downregulated the expression of various carcinogenic markers such as B-cell lymphoma 2 (Bcl-2), B-cell lymphoma-extra large (Bcl-xL), cyclin D1, cyclooxygenase 2 (COX-2), survivin, vascular endothelial growth factor (VEGF), and matrix metallopeptidases 9 (MMP-9).	evodiamine	20-23	cyclin D1	Homo sapiens	205-214
32183159-11	2020	Conducted experiments proved NFkB expression inhibition as well as cyclin D1 expression limitation under asoprisnil and ulipristal treatment.	asoprisnil	105-115	cyclin D1	Homo sapiens	67-76
32164284-4	2020	Focusing on pantoprazole, we show that it significantly reduced human cancer cell proliferation by inhibiting cellular H+ extrusion, increasing K+ conductance and promoting cyclin D1-dependent cell cycle arrest and preventing STAT3 activation.	Pantoprazole	12-24	cyclin D1	Homo sapiens	173-182
33543028-8	2020	Interestingly, salicylate inhibited metastatic breast cancer cell proliferation and growth by inducing cell growth arrest without signs of apoptosis as evidenced by the substantial decrease of cyclin D1 protein and the absence of cleaved caspase-3, respectively.	Salicylates	15-25	cyclin D1	Homo sapiens	193-202
31154861-1	2020	The aim of this study was to evaluate the inhibitory effects of resveratrol (RSV) in A375 and A431 melanoma cells, by assessing cell viability (CCK-8 assay), apoptosis through flow cytometer and cell morphology, cell cycle assay by flow cytometer and western blot (Cyclin D1, Rac1 and PCDH9).	Resveratrol	64-75	cyclin D1	Homo sapiens	265-274
31705676-2	2020	GdCl3 (CaSR agonist) significantly increased the proliferation rate of MG-63 cells, the expression of PCNA and Cyclin D1 and decreased the expression of p21Cip/WAF-1 .	Gadolinium	0-5	cyclin D1	Homo sapiens	111-120
31595560-5	2020	In opposite to Matrine, Cisplatin treatment increases the ability of tumorsphere formation and the expression of BrCSCs markers, which was partially blocked by either Let-7b overexpression or CCND1 inhibition.	Cisplatin	24-33	cyclin D1	Homo sapiens	192-197
31038780-7	2020	The expression of Wnt/beta-catenin pathway markers (beta-catenin and cyclin D1) were enhanced after miR-103 overexpression.	mir-103	100-107	cyclin D1	Homo sapiens	69-78
31991293-4	2020	PURPOSE: The aim of the current study was to explore whether wogonin can suppress hepatocellular carcinoma (HCC) progression and the mechanism of wogonin in inhibiting Cyclin D1 expression.	wogonin	146-153	cyclin D1	Homo sapiens	168-177
31991293-8	2020	Moreover, the findings from the western blot and immunofluoscence assay confirmed the inhibition action of wogonin (10, 20 microM) on Cyclin D1 expression in MHCC97L cells, and wogonin (10, 20 microM) pre-treatment was capable of promoting Cyclin D1 ubiquitination and degradation in MHCC97L cell.	wogonin	107-114	cyclin D1	Homo sapiens	134-143
31991293-8	2020	Moreover, the findings from the western blot and immunofluoscence assay confirmed the inhibition action of wogonin (10, 20 microM) on Cyclin D1 expression in MHCC97L cells, and wogonin (10, 20 microM) pre-treatment was capable of promoting Cyclin D1 ubiquitination and degradation in MHCC97L cell.	wogonin	107-114	cyclin D1	Homo sapiens	240-249
31991293-9	2020	In addition, wogonin promoted phosphorylation of Cyclin D1 on threonine-286 site, the mutation of threonine-286 to alanine-286A blocked Cyclin D1 proteolysis induced by wogonin.	wogonin	13-20	cyclin D1	Homo sapiens	49-58
31991293-9	2020	In addition, wogonin promoted phosphorylation of Cyclin D1 on threonine-286 site, the mutation of threonine-286 to alanine-286A blocked Cyclin D1 proteolysis induced by wogonin.	Threonine	62-71	cyclin D1	Homo sapiens	49-58
31991293-9	2020	In addition, wogonin promoted phosphorylation of Cyclin D1 on threonine-286 site, the mutation of threonine-286 to alanine-286A blocked Cyclin D1 proteolysis induced by wogonin.	wogonin	169-176	cyclin D1	Homo sapiens	49-58
31991293-9	2020	In addition, wogonin promoted phosphorylation of Cyclin D1 on threonine-286 site, the mutation of threonine-286 to alanine-286A blocked Cyclin D1 proteolysis induced by wogonin.	wogonin	169-176	cyclin D1	Homo sapiens	136-145
31991293-10	2020	Wogonin-promoted Cyclin D1 phosphorylation and subsequent proteolysis may associate with the activation of GSK3beta in cancer cells.	wogonin	0-7	cyclin D1	Homo sapiens	17-26
31751608-7	2020	Glyphosate decreased expression of P16 and TP53 as well as an increase in the expression of BCl2, CCND1 and P21.	glyphosate	0-10	cyclin D1	Homo sapiens	98-103
32343239-8	2020	Both lanthanum citrate and KAAD-cyclopamine downregulated the protein expressions of CyclinD1, Bcl-2, Gli1, and Shh and upregulated the protein expressions of p21 and Caspase-3.	lanthanum citrate	5-22	cyclin D1	Homo sapiens	85-93
32343239-8	2020	Both lanthanum citrate and KAAD-cyclopamine downregulated the protein expressions of CyclinD1, Bcl-2, Gli1, and Shh and upregulated the protein expressions of p21 and Caspase-3.	kaad	27-31	cyclin D1	Homo sapiens	85-93
32343239-8	2020	Both lanthanum citrate and KAAD-cyclopamine downregulated the protein expressions of CyclinD1, Bcl-2, Gli1, and Shh and upregulated the protein expressions of p21 and Caspase-3.	cyclopamine	32-43	cyclin D1	Homo sapiens	85-93
32081843-11	2020	Finally, we chose the top 5 common targets, CCND1, EGFR, IL6, MAPK8, and VEGFA, for molecular docking with the 11 active ingredients of CS.	Cesium	136-138	cyclin D1	Homo sapiens	44-49
32090087-8	2020	Inhibition of miR-326-3p also decreased the number of cells entering the G2/M phase and the expression of cyclin D1.	mir-326-3p	14-24	cyclin D1	Homo sapiens	106-115
32041324-4	2020	Z-Ajoene repressed beta-catenin response transcriptional activity, intracellular beta-catenin levels, and its representative target protein levels (c-Myc and cyclin D1) in SW480 colon cancer cells.	(Z)-Ajoene	0-8	cyclin D1	Homo sapiens	158-167
32103979-12	2020	Moreover, Wnt/beta-catenin pathway inhibitor XAV939 could inhibit the expressions of c-myc, cyclin D1 and beta-catenin, but activator LiCl could promote their expression.	XAV939	45-51	cyclin D1	Homo sapiens	92-101
32055740-8	2020	In addition, the expression of some genes involved in cell cycle, protein quality control, and neurotransmission such as cyclin D1, HSP70, and ACHE genes was differentially expressed in the presence of these chemicals, most noticeably in treatment of VB.	Benzoates	251-253	cyclin D1	Homo sapiens	121-130
32027811-0	2020	Comment on "Everolimus induces G1 cell arrest through autophagy-mediated protein degradation of cyclin D1 in breast cancer cells".	everolimus	12-22	cyclin D1	Homo sapiens	96-105
32102502-0	2020	Activation of MAPK and Cyclin D1/CDK4 in Malignant Transformation of Human Embryonic Lung Fibroblasts Induced by Silica and Benzopyrene.	Silicon Dioxide	113-119	cyclin D1	Homo sapiens	23-32
32102502-0	2020	Activation of MAPK and Cyclin D1/CDK4 in Malignant Transformation of Human Embryonic Lung Fibroblasts Induced by Silica and Benzopyrene.	Benzopyrenes	124-135	cyclin D1	Homo sapiens	23-32
32102502-4	2020	The expression of cyclin D1 and CDK4 (cyclin dependent kinase) were measured in silica and B(a)P induced malignant using Western blot (WB) assay.	Silicon Dioxide	80-86	cyclin D1	Homo sapiens	18-27
32102502-8	2020	CONCLUSION: MAPK and cyclin D1/CDK4 activation expressed differently in human embryo lung fibroblasts malignant transformation induced by silica and benzopyrene.	Silicon Dioxide	138-144	cyclin D1	Homo sapiens	21-30
32102502-8	2020	CONCLUSION: MAPK and cyclin D1/CDK4 activation expressed differently in human embryo lung fibroblasts malignant transformation induced by silica and benzopyrene.	Benzopyrenes	149-160	cyclin D1	Homo sapiens	21-30
31661371-8	2020	Taken together, these data demonstrate that suppression of CCND1 by miR-519d-3p might be a therapeutic target for glioma.Abbreviations miR-519d-3p: microRNA-519d-3p; CCND1: Cyclin D1; ATCC: American Type Culture Collection; MTT: 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide; PI: propidium iodide; WT: wild type; MUT: mutant type; SD: standard deviation.	thiazolyl blue	224-227	cyclin D1	Homo sapiens	59-64
31661371-8	2020	Taken together, these data demonstrate that suppression of CCND1 by miR-519d-3p might be a therapeutic target for glioma.Abbreviations miR-519d-3p: microRNA-519d-3p; CCND1: Cyclin D1; ATCC: American Type Culture Collection; MTT: 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide; PI: propidium iodide; WT: wild type; MUT: mutant type; SD: standard deviation.	thiazolyl blue	224-227	cyclin D1	Homo sapiens	166-171
31661371-8	2020	Taken together, these data demonstrate that suppression of CCND1 by miR-519d-3p might be a therapeutic target for glioma.Abbreviations miR-519d-3p: microRNA-519d-3p; CCND1: Cyclin D1; ATCC: American Type Culture Collection; MTT: 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide; PI: propidium iodide; WT: wild type; MUT: mutant type; SD: standard deviation.	thiazolyl blue	224-227	cyclin D1	Homo sapiens	173-182
31661371-8	2020	Taken together, these data demonstrate that suppression of CCND1 by miR-519d-3p might be a therapeutic target for glioma.Abbreviations miR-519d-3p: microRNA-519d-3p; CCND1: Cyclin D1; ATCC: American Type Culture Collection; MTT: 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide; PI: propidium iodide; WT: wild type; MUT: mutant type; SD: standard deviation.	thiazolyl blue	229-291	cyclin D1	Homo sapiens	59-64
31661371-8	2020	Taken together, these data demonstrate that suppression of CCND1 by miR-519d-3p might be a therapeutic target for glioma.Abbreviations miR-519d-3p: microRNA-519d-3p; CCND1: Cyclin D1; ATCC: American Type Culture Collection; MTT: 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide; PI: propidium iodide; WT: wild type; MUT: mutant type; SD: standard deviation.	thiazolyl blue	229-291	cyclin D1	Homo sapiens	166-171
31661371-8	2020	Taken together, these data demonstrate that suppression of CCND1 by miR-519d-3p might be a therapeutic target for glioma.Abbreviations miR-519d-3p: microRNA-519d-3p; CCND1: Cyclin D1; ATCC: American Type Culture Collection; MTT: 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide; PI: propidium iodide; WT: wild type; MUT: mutant type; SD: standard deviation.	thiazolyl blue	229-291	cyclin D1	Homo sapiens	173-182
31661371-8	2020	Taken together, these data demonstrate that suppression of CCND1 by miR-519d-3p might be a therapeutic target for glioma.Abbreviations miR-519d-3p: microRNA-519d-3p; CCND1: Cyclin D1; ATCC: American Type Culture Collection; MTT: 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide; PI: propidium iodide; WT: wild type; MUT: mutant type; SD: standard deviation.	Propidium	297-313	cyclin D1	Homo sapiens	59-64
31661371-8	2020	Taken together, these data demonstrate that suppression of CCND1 by miR-519d-3p might be a therapeutic target for glioma.Abbreviations miR-519d-3p: microRNA-519d-3p; CCND1: Cyclin D1; ATCC: American Type Culture Collection; MTT: 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide; PI: propidium iodide; WT: wild type; MUT: mutant type; SD: standard deviation.	Propidium	297-313	cyclin D1	Homo sapiens	166-171
31661371-8	2020	Taken together, these data demonstrate that suppression of CCND1 by miR-519d-3p might be a therapeutic target for glioma.Abbreviations miR-519d-3p: microRNA-519d-3p; CCND1: Cyclin D1; ATCC: American Type Culture Collection; MTT: 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide; PI: propidium iodide; WT: wild type; MUT: mutant type; SD: standard deviation.	Propidium	297-313	cyclin D1	Homo sapiens	173-182
31902649-7	2020	Western blot analysis of cell cycle-related proteins Cyclin A, Cyclin B1 and Cyclin D1 have further confirmed the cell cycle arrest was induced by the ectopic expression of miR-140-3p.	mir-140-3p	173-183	cyclin D1	Homo sapiens	77-86
31832810-0	2020	6-Gingerol induces cell-cycle G1-phase arrest through AKT-GSK 3beta-cyclin D1 pathway in renal-cell carcinoma.	gingerol	0-10	cyclin D1	Homo sapiens	68-77
31832810-7	2020	Western-blotting results showed that 6-gingerol reduces phosphorylation of protein kinase B (AKT) Ser 473, cyclin-dependent kinases (CDK4), and cyclin D1 and, meanwhile, increases glycogen synthase kinase (GSK 3beta) protein amount.	gingerol	37-47	cyclin D1	Homo sapiens	144-153
31832810-9	2020	CONCLUSION: The above results indicate that 6-gingerol can induce cell-cycle arrest and cell-growth inhibition through the AKT-GSK 3beta-cyclin D1 signaling pathway in vitro and in vivo, suggesting that 6-gingerol should be useful for renal-cell carcinoma treatment.	gingerol	44-54	cyclin D1	Homo sapiens	137-146
31832810-9	2020	CONCLUSION: The above results indicate that 6-gingerol can induce cell-cycle arrest and cell-growth inhibition through the AKT-GSK 3beta-cyclin D1 signaling pathway in vitro and in vivo, suggesting that 6-gingerol should be useful for renal-cell carcinoma treatment.	gingerol	203-213	cyclin D1	Homo sapiens	137-146
31797547-7	2020	In addition, treatment of HeLa cells with PGG significantly reduced the protein levels of cyclin D1, Bcl-2 and STAT3 phosphorylation.	Glucose	42-45	cyclin D1	Homo sapiens	90-99
31154861-1	2020	The aim of this study was to evaluate the inhibitory effects of resveratrol (RSV) in A375 and A431 melanoma cells, by assessing cell viability (CCK-8 assay), apoptosis through flow cytometer and cell morphology, cell cycle assay by flow cytometer and western blot (Cyclin D1, Rac1 and PCDH9).	Resveratrol	77-80	cyclin D1	Homo sapiens	265-274
31154861-4	2020	According to the outcomes obtained from statistical analyses, Cyclin D1 and PCDH9 were strongly affected by RSV duration while Rac1 was not influenced.	Resveratrol	108-111	cyclin D1	Homo sapiens	62-71
31879047-0	2020	Dihydroartemisinin inhibits the growth and invasion of gastric cancer cells by regulating cyclin D1-CDK4-Rb signaling.	artenimol	0-18	cyclin D1	Homo sapiens	90-99
31960187-6	2020	RESULT: This review tries to highlight the effect of itraconazole on smoothened receptor (SMO) in the Hedgehog pathway, thereby reducing the glioma-associated oncogene homolog (GLI) release and finally exhibiting a range of anticancer effects, promoting apoptosis of cancer cells, and inhibiting proliferation by indirect inhibition of NF-kappaB pathway and inflammation, moreover, promoting the expression of cyclin-dependent kinase inhibitors, inhibiting the expression of target genes transcribed by GLI such as BCL-2 and Cyclin-D1.	Itraconazole	53-65	cyclin D1	Homo sapiens	525-534
31879047-5	2020	qRT-PCR and Western blot analyses were used to determine the effects of DHA on the cyclin D1-CDK4-Rb signaling pathway.	artenimol	72-75	cyclin D1	Homo sapiens	83-92
31870592-6	2020	CD could suppress proliferation, invasion and migration of glioma cells and induced reduction of cyclinE, cyclinD1, CTGF, MMP-2 and MMP-9 expression via activating JNK signaling pathway.	coronarin D	0-2	cyclin D1	Homo sapiens	106-114
31879047-7	2020	DHA suppressed cell proliferation, migration and invasion in vitro and in vivo and induced G1 phase cell cycle arrest in a dose-dependent manner by regulating cyclin D1-CDK4-Rb signaling.	artenimol	0-3	cyclin D1	Homo sapiens	159-168
31879047-8	2020	CONCLUSIONS: DHA inhibits the tumorigenesis and invasion of GC by regulating cyclin D1-CDK4-Rb signaling and may provide therapeutic strategies for the treatment of GC.	artenimol	13-16	cyclin D1	Homo sapiens	77-86
32296029-5	2020	NT157 treatment inhibited IRS1/2, JAK2/STAT, and NFkappaB signaling, and it activated the AP-1 complex, downregulated four oncogenes (CCND1, MYB, WT1, and NFKB1), and upregulated three apoptotic-related genes (CDKN1A, FOS, and JUN) (p < 0.05).	NT157	0-5	cyclin D1	Homo sapiens	134-139
31840737-0	2020	Isoliquiritigenin inhibits the proliferation, migration and metastasis of Hep3B cells via suppressing cyclin D1 and PI3K/AKT pathway.	isoliquiritigenin	0-17	cyclin D1	Homo sapiens	102-111
31840737-8	2020	Mechanistic analysis revealed that ISL inhibited cyclin D1 and up-regulated the proteins P21, P27 that negatively regulate the cell cycle.	isoliquiritigenin	35-38	cyclin D1	Homo sapiens	49-58
31982864-6	2020	AURKB is able to activate the expression of CCND1 through mediating H3S10ph in the promoter of the CCND1 gene.	h3s10ph	68-75	cyclin D1	Homo sapiens	44-49
31982864-6	2020	AURKB is able to activate the expression of CCND1 through mediating H3S10ph in the promoter of the CCND1 gene.	h3s10ph	68-75	cyclin D1	Homo sapiens	99-104
31982864-7	2020	Furthermore, we show that AZD1152, a specific inhibitor of AURKB, can suppress the expression of CCND1 in the gastric cancer cells and inhibit cell proliferation in vitro and in vivo.	2-((3-((4-((5-(2-((3-fluorophenyl)amino)-2-oxoethyl)-1H-pyrazol-3-yl)amino)quinazolin-7-yl)oxy)propyl)(ethyl)amino)ethyl dihydrogen phosphate	26-33	cyclin D1	Homo sapiens	97-102
31961892-10	2020	Further, inhibition of endogenous Atox1 by siRNA in SW620 decreased colony formation and reactive oxygen species generation via decreased expression of Atox1 targets cyclin D1 and NADPH oxidase subunit p47 phox, respectively.	Oxygen	98-104	cyclin D1	Homo sapiens	166-175
31961892-10	2020	Further, inhibition of endogenous Atox1 by siRNA in SW620 decreased colony formation and reactive oxygen species generation via decreased expression of Atox1 targets cyclin D1 and NADPH oxidase subunit p47 phox, respectively.	NADP	180-185	cyclin D1	Homo sapiens	166-175
31809756-9	2020	Treatment with sesamin caused cell cycle arrest at G1 phase and inhibited cyclin D1 and CDK2 expression.	sesamin	15-22	cyclin D1	Homo sapiens	74-83
31756335-0	2020	Triptolide inhibits PDGF-induced proliferation of ASMCs through G0/G1 cell cycle arrest and suppression of the AKT/NF-kappaB/cyclinD1 signaling pathway.	triptolide	0-10	cyclin D1	Homo sapiens	125-133
31756335-9	2020	Triptolide could significantly inhibit cell proliferation, induce cell cycle arrest in the G0/G1 phase, and reduce the expression of PCNA, cyclinD1, and CDK4 in PDGF-treated ASMCs.	triptolide	0-10	cyclin D1	Homo sapiens	139-147
31756335-11	2020	Moreover, triptolide cotreatment with the phosphatidylinositol 3 kinase (PI3k) inhibitor, 2-(4-morpholinyl)-8-phenylchromone (LY294002), could further suppress the proliferation, NF-kappaB activation and cyclinD1 expression.	triptolide	10-20	cyclin D1	Homo sapiens	204-212
31756335-11	2020	Moreover, triptolide cotreatment with the phosphatidylinositol 3 kinase (PI3k) inhibitor, 2-(4-morpholinyl)-8-phenylchromone (LY294002), could further suppress the proliferation, NF-kappaB activation and cyclinD1 expression.	2-(4-morpholinyl)-8-phenylchromone	90-124	cyclin D1	Homo sapiens	204-212
31756335-11	2020	Moreover, triptolide cotreatment with the phosphatidylinositol 3 kinase (PI3k) inhibitor, 2-(4-morpholinyl)-8-phenylchromone (LY294002), could further suppress the proliferation, NF-kappaB activation and cyclinD1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	cyclin D1	Homo sapiens	204-212
31756335-13	2020	Our results suggest that triptolide could inhibit the PDGF-induced proliferation of ASMCs through G0/G1 cell cycle arrest and suppression of the AKT/NF-kappaB/cyclinD1 signaling pathway.	triptolide	25-35	cyclin D1	Homo sapiens	159-167
31678612-5	2020	By Western blot, cotinine induced phosphorylation of Stat3 and expression of cyclin D1 in UMUC3 cells.	Cotinine	17-25	cyclin D1	Homo sapiens	77-86
31830480-7	2020	Dysregulation of Wnt/beta-catenin signaling with Peruvoside treatment resulted in inhibition of cyclin D1 and c-Myc also observed in this study.	cannogenin thevetoside	49-59	cyclin D1	Homo sapiens	96-105
32010625-5	2019	We found that both endogenous, glucose-derived lactate and exogenous, lactate supplementation significantly affected the transcription of key oncogenes (MYC, RAS, and PI3KCA), transcription factors (HIF1A and E2F1), tumor suppressors (BRCA1, BRCA2) as well as cell cycle and proliferation genes involved in breast cancer (AKT1, ATM, CCND1, CDK4, CDKN1A, CDK2B) (0.001 &lt; p &lt; 0.05 for all genes).	Glucose	31-38	cyclin D1	Homo sapiens	333-338
32010625-5	2019	We found that both endogenous, glucose-derived lactate and exogenous, lactate supplementation significantly affected the transcription of key oncogenes (MYC, RAS, and PI3KCA), transcription factors (HIF1A and E2F1), tumor suppressors (BRCA1, BRCA2) as well as cell cycle and proliferation genes involved in breast cancer (AKT1, ATM, CCND1, CDK4, CDKN1A, CDK2B) (0.001 &lt; p &lt; 0.05 for all genes).	Lactic Acid	47-54	cyclin D1	Homo sapiens	333-338
32010625-5	2019	We found that both endogenous, glucose-derived lactate and exogenous, lactate supplementation significantly affected the transcription of key oncogenes (MYC, RAS, and PI3KCA), transcription factors (HIF1A and E2F1), tumor suppressors (BRCA1, BRCA2) as well as cell cycle and proliferation genes involved in breast cancer (AKT1, ATM, CCND1, CDK4, CDKN1A, CDK2B) (0.001 &lt; p &lt; 0.05 for all genes).	Lactic Acid	70-77	cyclin D1	Homo sapiens	333-338
32907364-6	2020	Accompanied with cell cycle disruption, cucurbitacin B altered the expression of proteins involved in the G2/M phase transition including downregulation of cyclin A, cyclin D1, and cdc25A, and upregulation of p21.	cucurbitacin B	40-54	cyclin D1	Homo sapiens	166-175
31941067-8	2020	Accumulated evidence has revealed that Triphala modulates multiple cell signaling pathways including, ERK, MAPK, NF-kappaB, Akt, c-Myc, VEGFR, mTOR, tubulin, p53, cyclin D1, anti-apoptotic and pro-apoptotic proteins.	triphala	39-47	cyclin D1	Homo sapiens	163-172
31919338-9	2020	The expression of cyclin D1 and p21 proteins was significantly increased by 3,6-diazabicyclo[3.3.1]heptane in LNCaP and PC3 cells.	triethylenediamine	76-92	cyclin D1	Homo sapiens	18-27
31669217-6	2020	The results showed a positive relationship between fluoride exposure and expression of Cyclin d1/CDK4, and a negative relationship between fluoride exposure and expression of P21.	Fluorides	51-59	cyclin D1	Homo sapiens	87-96
31950839-8	2020	Noscapine showed anti-proliferative effects by decreasing Ki-67, cyclin-D1 and apoptotic effects by increasing BAX/Bcl-2 ratio in both breast cancer cells.	Noscapine	0-9	cyclin D1	Homo sapiens	65-74
31892560-8	2020	Immunohistochemical analysis of tumor tissues revealed down-regulation of cyclin D1 and proliferating cell nuclear antigen in the metformin-treated group.	Metformin	130-139	cyclin D1	Homo sapiens	74-83
32021099-11	2020	Further investigations revealed that aloin decreased the protein expression levels of cyclin D1, N-cadherin, and the matrix metalloproteinases (MMP)-2 and MMP-9; increased E-cadherin expression in a dose-dependent manner; inhibited reactive oxygen species (ROS) generation; and mediated the activation of Akt-mTOR, signal transducer and activator of transcription-3 (Stat3), and NF-kappaB signalling pathways.	alloin	37-42	cyclin D1	Homo sapiens	86-95
31707351-7	2020	In conclusion, 6Br-6a effectively inhibited activation of STAT3 and induced cell cycle arrest and apoptosis via regulating cyclin D1 and Bcl-2 expression.	6br-6a	15-21	cyclin D1	Homo sapiens	123-132
31222373-2	2020	Our previous studies report that isorhapontigenin (ISO) down-regulates SOX2-mediated cyclin D1 induction and stem-like cell properties in glioma stem-like cells.	isorhapontigenin	33-49	cyclin D1	Homo sapiens	85-94
31747859-2	2020	Our previous study showed that CDK4/Cyclin D1 phosphorylates p53-RS at the cancer-derived Ser249 and promotes its interaction with c-Myc in the nucleus, consequently enhancing c-Myc-dependent ribosomal biogenesis and HCC cell proliferation.	seryl-seryl-seryl-arginine	90-93	cyclin D1	Homo sapiens	36-45
31222373-2	2020	Our previous studies report that isorhapontigenin (ISO) down-regulates SOX2-mediated cyclin D1 induction and stem-like cell properties in glioma stem-like cells.	isorhapontigenin	51-54	cyclin D1	Homo sapiens	85-94
32193954-9	2020	There was a significant upregulation of mRNA expression of Axin2, c-Myc, and Cyclin D1 genes of the Wnt/beta-catenin axis in ISCs treated with HMDEs (6.99 +- 2.34, 4.21 +- 1.68, 6.17 +- 2.22, respectively, P < 0.05 for all), as compared to control.	hmdes	143-148	cyclin D1	Homo sapiens	77-86
31786976-12	2020	Adenosine inhibits P-SMC migration and proliferation via the A2B receptor/cyclic AMP/protein kinase A axis, which reduces cyclin D1 expression and activity via inhibiting Akt phosphorylation and Skp2 expression and upregulating p27kip1 levels.	Adenosine	0-9	cyclin D1	Homo sapiens	122-131
32907379-6	2020	ADAR1 and cyclin D1 protein levels were dramatically decreased, while p53 and p21 levels were increased after 8-Cl-Ado exposure.	8-chloroadenosine	110-118	cyclin D1	Homo sapiens	10-19
31667787-10	2020	Moreover, treatment with the autophagy activator rapamycin effectively abrogated the CCND1 silencing-reduced CD133 + cell percentage.	Sirolimus	49-58	cyclin D1	Homo sapiens	85-90
31786976-12	2020	Adenosine inhibits P-SMC migration and proliferation via the A2B receptor/cyclic AMP/protein kinase A axis, which reduces cyclin D1 expression and activity via inhibiting Akt phosphorylation and Skp2 expression and upregulating p27kip1 levels.	Cyclic AMP	74-84	cyclin D1	Homo sapiens	122-131
32405344-8	2020	Crocin can induce apoptosis through activation of caspase 8, up-regulation of p53 expression, Bax/Bcl-2 ratio, and down-regulation expression of Bcl-2, survivin, and cyclin D1.	crocin	0-6	cyclin D1	Homo sapiens	166-175
32841893-14	2020	Significant reductions in cell survival, mutagenic activity, Cyclin D1, CDK4, Snail, and JAK2/STAT3 expression were found after inhibitor AG490, ANF and CHJ223191 treatment.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	138-143	cyclin D1	Homo sapiens	61-70
31949488-7	2020	In addition, the pro-apoptotic effect of sertindole on GC might in part, involved in inhibition of STAT3 activation and downstream signals, including Mcl1, surviving, c-Myc, cyclin D1.	sertindole	41-51	cyclin D1	Homo sapiens	174-183
31821701-5	2020	Lovastatin caused p21 elevation while reduced cyclin D1 and survivin levels.	Lovastatin	0-10	cyclin D1	Homo sapiens	46-55
32841893-14	2020	Significant reductions in cell survival, mutagenic activity, Cyclin D1, CDK4, Snail, and JAK2/STAT3 expression were found after inhibitor AG490, ANF and CHJ223191 treatment.	alpha-naphthoflavone	145-148	cyclin D1	Homo sapiens	61-70
32841893-14	2020	Significant reductions in cell survival, mutagenic activity, Cyclin D1, CDK4, Snail, and JAK2/STAT3 expression were found after inhibitor AG490, ANF and CHJ223191 treatment.	chj223191	153-162	cyclin D1	Homo sapiens	61-70
31816985-5	2019	Also, TMS-TMF-4f suppressed both constitutive and IL-6-inducible levels of phosphorylated STAT3 (p-STAT3) and associated proteins such as Mcl-1, cyclin D1, survivin, and c-Myc in both cervical cancer cells.	thiomarinol F	6-16	cyclin D1	Homo sapiens	145-154
30091007-6	2020	Effect of NF-Bp65 inhibitor (BAY-117082) on the proliferation and expression level of Cyclin D1 and PLD2 of colon cancer cells under hypoxic conditions were further analysised.	3-(4-methylphenylsulfonyl)-2-propenenitrile	29-39	cyclin D1	Homo sapiens	86-95
31831640-3	2019	We found that p27, when phosphorylated by tyrosine kinases, allosterically activated CDK4 in complex with cyclin D1 (CDK4-CycD1).	Tyrosine	42-50	cyclin D1	Homo sapiens	106-115
31780054-0	2020	Apigenin, a flavonoid constituent derived from P. villosa, inhibits hepatocellular carcinoma cell growth by CyclinD1/CDK4 regulation via p38 MAPK-p21 signaling.	Apigenin	0-8	cyclin D1	Homo sapiens	108-116
31780054-10	2020	CyclinD1 was up-regulated and CDK4 was down-regulated upon Apigenin treatment, which indicated that Apigenin could block cell cycle progression at the G1 phase though the regulation of CDK4 and CyclinD1 expression.	Apigenin	59-67	cyclin D1	Homo sapiens	194-202
31284780-0	2019	Baicalein blocked cervical carcinoma cell proliferation by targeting CCND1 via Wnt/beta-catenin signaling pathway.	baicalein	0-9	cyclin D1	Homo sapiens	69-74
30880481-7	2019	We found that, salidroside remarkably reduced cell viability, colony formation and Cyclin D1 expression, but increased p21 expression and apoptosis in A549 cells.	rhodioloside	15-26	cyclin D1	Homo sapiens	83-92
31284780-9	2019	In conclusion, it indicated that baicalein inhibits cervical carcinoma progression by targeting CCND1 via Wnt/beta-catenin signaling pathway.	baicalein	33-42	cyclin D1	Homo sapiens	96-101
31539270-8	2019	Compared with control group, curcumin significantly inhibited cell cycle progression in G0/G1-S phase, increased the cell number of G0/G1 phase, and downregulated the Bcl-2, CDK4, and cyclin D1 protein expression in cells and tissues (p &lt; 0.05).	Curcumin	29-37	cyclin D1	Homo sapiens	184-193
31432697-7	2019	Salidroside inhibited GC cells proliferation, migration, invasion and promoted apoptosis, which coupled with the down-regulation of p21, Bcl-2, MMP2, RhoA, p-ROCK1, Vimentin and the up-regulations of CyclinD1, Bax, cleaved caspases.	rhodioloside	0-11	cyclin D1	Homo sapiens	200-208
31616959-7	2019	The results showed elevated cyclin D1 mRNA levels in As(III)-exposed Het1A cells.	angoletin	53-60	cyclin D1	Homo sapiens	28-37
31616959-9	2019	Collectively, these findings indicate that the promotion of HB-EGF-induced migration of Het1A cells chronically exposed to submicromolar As(III) might be caused by increased expression of cyclin D1 mediated by enhanced activation of the ERK pathway.	angoletin	137-144	cyclin D1	Homo sapiens	188-197
31226499-7	2019	Furthermore, we designed two sets of double heptamer-type sgRNA, which target the human CCND1 mRNA, and both sets synergistically reduced RPMI-8226 cell viability.	rpmi	138-142	cyclin D1	Homo sapiens	88-93
31601147-5	2019	miR-342-5p overexpression remarkably suppressed the viability and invasion while enhanced the apoptosis of OS cells; meanwhile, Wnt7b, beta-catenin, c-myc, and cyclin D1 proteins were reduced while E-cadherin protein showed to be increased.	mir-342-5p	0-10	cyclin D1	Homo sapiens	160-169
31665911-6	2019	Further investigation showed that inhibition or down-regulation of PRMT5 further reduced Akt/GSK3beta phosphorylation and the downstream targets cyclin D1 and E1 expression upon resveratrol treatment.	Resveratrol	178-189	cyclin D1	Homo sapiens	145-154
31359579-6	2019	Dorsomorphin inhibited CRC cell growth by modulating the cyclinD1, surviving and p-Akt.	dorsomorphin	0-12	cyclin D1	Homo sapiens	57-65
31219186-11	2019	In melanoma cells transfected with miR-329 mimics or siRNA-HMGB2, cell proliferation, migration, and invasion were impeded, yet cell cycle arrest and apoptosis were promoted, corresponding to decreased levels of beta-catenin, cyclin D1, and vimentin and increased levels of GSK3beta and E-cadherin.	mir-329	35-42	cyclin D1	Homo sapiens	226-235
31744691-8	2019	Metformin promoted the expression of p-AMPK, P53, P21CIP1 and P27KIP1, while inhibited the expression of CDK4 and CyclinD1.	Metformin	0-9	cyclin D1	Homo sapiens	114-122
31120355-1	2019	In mantle cell lymphoma (MCL), cyclin D1 combines with CDK4/6 to phosphorylate Rb, releasing a break on the G1 to S phase cell cycle.	Rubidium	79-81	cyclin D1	Homo sapiens	31-40
31727500-8	2019	In addition, we found that naringin dose-dependently enhanced the expression of Caspase3, cleaved Caspase3 and Bax, and reduced the expression of cyclin D1, c-Myc, survivin, and Bcl-2 in TPC-1 and SW1736 cells.	naringin	27-35	cyclin D1	Homo sapiens	146-155
31801187-3	2019	In particular, we showed that nanomolar concentrations of (Bu2Sn)2TPPS and (Bu3Sn)4TPPS are sufficient to inhibit melanoma cell growth, to increase the expression of the full-length poly (ADP-ribose) polymerase (PARP-1), to induce the cell cycle arrest respectively at G2/M and G0/G1 through the inhibition of the Cyclin D1 expression and to inhibit cell colony formation.	(bu2sn)2tpps	58-70	cyclin D1	Homo sapiens	314-323
31801187-3	2019	In particular, we showed that nanomolar concentrations of (Bu2Sn)2TPPS and (Bu3Sn)4TPPS are sufficient to inhibit melanoma cell growth, to increase the expression of the full-length poly (ADP-ribose) polymerase (PARP-1), to induce the cell cycle arrest respectively at G2/M and G0/G1 through the inhibition of the Cyclin D1 expression and to inhibit cell colony formation.	(bu3sn)4tpps	75-87	cyclin D1	Homo sapiens	314-323
31563649-5	2019	Further studies revealed that nitidine chloride inhibited HaCaT proliferation and induced S phase cell cycle arrest; these effects were associated with reduced DNA synthesis, decreased Ki67, cyclin A, and cyclin D1 levels, and increased p53 protein expression.	nitidine	30-47	cyclin D1	Homo sapiens	205-214
31684907-0	2019	AIB1 sequestration by androgen receptor inhibits estrogen-dependent cyclin D1 expression in breast cancer cells.	Estrogens	49-57	cyclin D1	Homo sapiens	68-77
31684907-5	2019	RESULTS: Here we demonstrated, in estrogen receptor alpha (ERalpha)-positive breast cancer cells, an androgen-dependent mechanism through which ligand-activated androgen receptor (AR) decreases estradiol-induced cyclin D1 protein, mRNA and gene promoter activity.	Androgens	101-109	cyclin D1	Homo sapiens	212-221
31684907-5	2019	RESULTS: Here we demonstrated, in estrogen receptor alpha (ERalpha)-positive breast cancer cells, an androgen-dependent mechanism through which ligand-activated androgen receptor (AR) decreases estradiol-induced cyclin D1 protein, mRNA and gene promoter activity.	Estradiol	194-203	cyclin D1	Homo sapiens	212-221
31684907-6	2019	These effects involve the competition between AR and ERalpha for the interaction with the steroid receptor coactivator AIB1, a limiting factor in the functional coupling of the ERalpha with the cyclin D1 promoter.	Steroids	90-97	cyclin D1	Homo sapiens	194-203
31684907-9	2019	In addition, ChIP analysis evidenced that androgen administration decreased E2-induced recruitment of AIB1 on the AP-1 site containing region of the cyclin D1 gene promoter.	Androgens	42-50	cyclin D1	Homo sapiens	149-158
31684907-10	2019	CONCLUSIONS: Taken together all these data support the hypothesis that AIB1 sequestration by AR may be an effective mechanism to explain the reduction of estrogen-induced cyclin D1 gene activity.	Estrogens	154-162	cyclin D1	Homo sapiens	171-180
31815042-0	2019	Benzethonium chloride suppresses lung cancer tumorigenesis through inducing p38-mediated cyclin D1 degradation.	Benzethonium	0-21	cyclin D1	Homo sapiens	89-98
31815042-6	2019	Mechanistically, quantitative proteomics coupled with bioinformatics analyses and a series of functional assays demonstrated that BZN induced cell cycle arrest at G1 phase, and this was associated with an increase in p38-mediated phosphorylation at threonine 286 (T286) and accelerated degradation of cyclin D1.	Benzethonium	130-133	cyclin D1	Homo sapiens	301-310
31882431-8	2019	Meanwhile, cisplatin chemosensitivity was enhanced by PDRG1 knockdown, via the suppression of cyclinD1 and beta-catenin expression within esophageal cancer cells.	Cisplatin	11-20	cyclin D1	Homo sapiens	94-102
31742207-11	2019	Conclusion: Addition of emodin attenuated tamoxifen"s treatment effect via cyclin D1 and pERK up-regulation in ER-positive breast cancer cell lines.	Tamoxifen	42-51	cyclin D1	Homo sapiens	75-84
31553107-7	2019	The STAT3 inhibitor S3I-201 suppressed cyclin D1 expression and cell proliferation and the overexpression of STAT3 enhanced cyclin D1 expression and accelerated proliferation.	8,2'-S-cycloinosinyl-(3',5')-8,2'-S-cycloadenosine	20-23	cyclin D1	Homo sapiens	39-48
31553107-10	2019	Inhibition of p70S6K /p85S6K by rapamycin also reduced the expressions of STAT3 and cyclin D1.	Sirolimus	32-41	cyclin D1	Homo sapiens	84-93
31388935-5	2019	RESULTS: The combination treatment with AEE788 and rapalog effectively inhibits phosphorylation of mTOR and 4EBP1, relieves mTOR inhibition-mediated upregulation of cyclin D1, and maintains suppression of AKT and ERK signaling, thereby sensitizing TNBC cells to the rapalogs.	AEE 788	40-46	cyclin D1	Homo sapiens	165-174
31388935-5	2019	RESULTS: The combination treatment with AEE788 and rapalog effectively inhibits phosphorylation of mTOR and 4EBP1, relieves mTOR inhibition-mediated upregulation of cyclin D1, and maintains suppression of AKT and ERK signaling, thereby sensitizing TNBC cells to the rapalogs.	rapalog	51-58	cyclin D1	Homo sapiens	165-174
31428968-0	2019	BCR-ABL induces tyrosine phosphorylation of YAP leading to expression of Survivin and Cyclin D1 in chronic myeloid leukemia cells.	Tyrosine	16-24	cyclin D1	Homo sapiens	86-95
31428968-6	2019	YAP was phosphorylated at Y357 constitutively in BCR-ABL stable transfectant but not in control transfectant, and treatment with imatinib or RK-20449, a Src family kinase-specific inhibitor, inhibited cell growth, YAP tyrosine phosphorylation, and expression of Cyclin D1 in BCR-ABL stable transfectant.	Imatinib Mesylate	129-137	cyclin D1	Homo sapiens	262-271
31001861-11	2019	The percentage of the S phase cells was evidently reduced by Nimotuzuma through regulating P21, Cyclin E1, and Cyclin D1.	nimotuzuma	61-71	cyclin D1	Homo sapiens	111-120
31574243-0	2019	Omethoate induces pharyngeal cancer cell proliferation and G1/S cell cycle progression by activation of Akt/GSK-3beta/cyclin D1 signaling pathway.	dimethoxon	0-9	cyclin D1	Homo sapiens	118-127
31517438-0	2019	Iron chelation and 2-oxoglutarate-dependent dioxygenase inhibition suppress mantle cell lymphoma"s cyclin D1.	Iron	0-4	cyclin D1	Homo sapiens	99-108
31517438-2	2019	We observed that iron (an essential cofactor of dioxygenases including prolyl hydroxylases [PHDs]) depletion by deferoxamine blocked MCL cells" proliferation, increased expression of DNA damage marker gammaH2AX, induced cell cycle arrest and decreased cyclin D1 level.	Iron	17-21	cyclin D1	Homo sapiens	252-261
31517438-2	2019	We observed that iron (an essential cofactor of dioxygenases including prolyl hydroxylases [PHDs]) depletion by deferoxamine blocked MCL cells" proliferation, increased expression of DNA damage marker gammaH2AX, induced cell cycle arrest and decreased cyclin D1 level.	Deferoxamine	112-124	cyclin D1	Homo sapiens	252-261
31517438-3	2019	Treatment of MCL cell lines with dimethyloxalylglycine, which blocks dioxygenases involving PHDs by competing with their substrate 2-oxoglutarate, leads to their decreased proliferation and the decrease of cyclin D1 level.	oxalylglycine	33-54	cyclin D1	Homo sapiens	206-215
31517438-6	2019	These data suggest that expression of cyclin D1 in MCL is not controlled by ENGL2/PHD1-FOXO3A pathway and that chelation- and 2-oxoglutarate competition-mediated down-regulation of cyclin D1 in MCL cells is driven by yet unknown mechanism involving iron- and 2-oxoglutarate-dependent dioxygenases other than PHD1.	Ketoglutaric Acids	126-140	cyclin D1	Homo sapiens	38-47
31517438-6	2019	These data suggest that expression of cyclin D1 in MCL is not controlled by ENGL2/PHD1-FOXO3A pathway and that chelation- and 2-oxoglutarate competition-mediated down-regulation of cyclin D1 in MCL cells is driven by yet unknown mechanism involving iron- and 2-oxoglutarate-dependent dioxygenases other than PHD1.	Ketoglutaric Acids	126-140	cyclin D1	Homo sapiens	181-190
31517438-6	2019	These data suggest that expression of cyclin D1 in MCL is not controlled by ENGL2/PHD1-FOXO3A pathway and that chelation- and 2-oxoglutarate competition-mediated down-regulation of cyclin D1 in MCL cells is driven by yet unknown mechanism involving iron- and 2-oxoglutarate-dependent dioxygenases other than PHD1.	Iron	249-253	cyclin D1	Homo sapiens	38-47
31517438-6	2019	These data suggest that expression of cyclin D1 in MCL is not controlled by ENGL2/PHD1-FOXO3A pathway and that chelation- and 2-oxoglutarate competition-mediated down-regulation of cyclin D1 in MCL cells is driven by yet unknown mechanism involving iron- and 2-oxoglutarate-dependent dioxygenases other than PHD1.	Iron	249-253	cyclin D1	Homo sapiens	181-190
31517438-6	2019	These data suggest that expression of cyclin D1 in MCL is not controlled by ENGL2/PHD1-FOXO3A pathway and that chelation- and 2-oxoglutarate competition-mediated down-regulation of cyclin D1 in MCL cells is driven by yet unknown mechanism involving iron- and 2-oxoglutarate-dependent dioxygenases other than PHD1.	Ketoglutaric Acids	259-273	cyclin D1	Homo sapiens	38-47
31517438-6	2019	These data suggest that expression of cyclin D1 in MCL is not controlled by ENGL2/PHD1-FOXO3A pathway and that chelation- and 2-oxoglutarate competition-mediated down-regulation of cyclin D1 in MCL cells is driven by yet unknown mechanism involving iron- and 2-oxoglutarate-dependent dioxygenases other than PHD1.	Ketoglutaric Acids	259-273	cyclin D1	Homo sapiens	181-190
31612027-5	2019	A total of 6 ATO target genes (namely AKT1, CCND1, CDKN2A, IKBKB, MAPK1 and MAPK3) were found to be associated with pancreatic cancer.	ato	13-16	cyclin D1	Homo sapiens	44-49
31467112-5	2019	Mechanistically, the -141T allele of Ht2 creates a novel ZEB1 binding site; meanwhile, the -78C allele of Ht1 exists as an emerging KLF5 binding site, which synergistically induces promote/inhibit mTOR expression, cell proliferation and excretion of cytotoxic drugs through the ZEB1/KLF5-mTOR-CCND1/ABCB1 cascade, thereby affecting the response to PTX treatment in vivo and in vitro.	Paclitaxel	348-351	cyclin D1	Homo sapiens	293-298
31467112-6	2019	Our results suggest the existence of a ZEB1/KLF5-mTOR-CCND1/ABCB1 axis in human cells that could be involved in PTX response pathways and functionally regulate inter-individualized breast cancer susceptibility and prognosis.	Paclitaxel	112-115	cyclin D1	Homo sapiens	54-59
31467112-7	2019	Implications: The current study highlights the function of haplotypes of mTOR -78C/-141G and -78G/-141T, in affecting breast cancer susceptibility and PTX response regulated by ZEB1/KLF5-mTOR-CCND1/ABCB1 axis.	Paclitaxel	151-154	cyclin D1	Homo sapiens	192-197
31574243-7	2019	We also found that omethoate up-regulated cyclin D1, a key gene controlling the G1-S transition.	dimethoxon	19-28	cyclin D1	Homo sapiens	42-51
31574243-9	2019	Blockage of Akt by siRNA or small molecule inhibitor significantly suppressed omethoate-induced cyclin D1 expression and cell proliferation.	dimethoxon	78-87	cyclin D1	Homo sapiens	96-105
31574243-10	2019	Collectively, these findings demonstrated for the first time that omethoate could induce the pharyngeal cancer cell proliferation by activation of the Akt/GSK-3beta/cyclin D1 signaling pathway.	dimethoxon	66-75	cyclin D1	Homo sapiens	165-174
31671572-7	2019	These results indicate that ethanol-induced dysregulation of NRF2 coordinately regulates PCNA/CYCLIN-D1/p21 involving growth network, at least partially to set a stage for placental perturbations.	Ethanol	28-35	cyclin D1	Homo sapiens	94-103
31635244-9	2019	beta- Caryophyllene induced G1 cell cycle arrest by downregulating cyclin D1, cyclin E, cyclin-dependent protein kinase (CDK) -2, -4, and -6, and RB phosphorylation, and by upregulating p21CIP1/WAF1 and p27KIP1.	caryophyllene	6-19	cyclin D1	Homo sapiens	67-76
31648230-5	2019	Treatment with FND-4b for 24h resulted in a marked induction of phosphorylated AMPK expression and a concomitant reduction in markers of cell proliferation, such as cyclin D1, in all CRC cell lines.	fnd-4b	15-21	cyclin D1	Homo sapiens	165-174
31661890-7	2019	It was shown that DMF induces a cell cycle arrest in G0/G1 phase, which is accompanied by upregulation of p21 and downregulation of cyclin D1 and Cyclin dependent kinase (CDK)4.	dimethyl fumarate	18-21	cyclin D1	Homo sapiens	132-141
31637187-7	2019	In addition, PTL induced the apoptosis of C918 cells, and decreased the expressions of Cyclin D1, B-cell lymphoma-2 (Bcl-2) and B-cell lymphoma-extra large (Bcl-XL).	parthenolide	13-16	cyclin D1	Homo sapiens	87-96
31680960-0	2019	Akt Regulated Phosphorylation of GSK-3beta/Cyclin D1, p21 and p27 Contributes to Cell Proliferation Through Cell Cycle Progression From G1 to S/G2M Phase in Low-Dose Arsenite Exposed HaCat Cells.	Arsenites	166-174	cyclin D1	Homo sapiens	43-52
31637188-10	2019	Obtusifolin reduced the expression of Cyclin D1 and proliferating cell nuclear antigen (PCNA) in the hypoxic environment and increased the expression of p53 and p21.	obtusifolin	0-11	cyclin D1	Homo sapiens	38-47
31623109-5	2019	The DETA/NO induced a dose and time-dependent reduction in cell viability by the activation of caspase-3 and cell cycle arrest at the G0/G1 phase that was associated with the attenuated expression of cyclin-D1 and D3.	DEET	4-8	cyclin D1	Homo sapiens	200-209
31615010-5	2019	Androgen signaling induces the overexpression of prostate-specific antigen (PSA) and cell proliferation factor such as proliferating cell nuclear antigen (PCNA) and cyclin D1.	Androgens	0-8	cyclin D1	Homo sapiens	165-174
31680960-10	2019	Our findings indicated that the phosphorylated activation of Akt played a role in the proliferation of HaCat cells upon long-term, low-dose NaAsO2 exposure through the phosphorylative regulation of its downstream cell cycle regulating factors of GSK-3beta/cyclin D1, p21 and p27, which could induce the promotion of cell cycle progression from G1 to S/G2M phase.	Sodium	140-146	cyclin D1	Homo sapiens	256-265
31649888-3	2019	Atorvastatin inhibited K562 and HL60 cell proliferation, induced G2/M cell cycle arrest in K562 cells by down-regulating cyclinB1 and cdc2, but G0/G1 arrest in HL60 cells by up-regulating p27 and down-regulating cyclinD1 and p-pRb.	atorvastatin	0-12	cyclin D1	Homo sapiens	212-220
31618367-10	2019	Furthermore, SchA inhibited cell proliferation and cyclin D1 expression.	schizandrin A	13-17	cyclin D1	Homo sapiens	51-60
31608167-11	2019	In addition, gene expression analysis revealed that MnIII complex exerts its antiproliferative effect via up-and down-regulation of p21 and cyclin D1, respectively, along with increased expression of Bax/Bcl-2 ratio, TNF-alpha, initiator caspase-8 and -10 and effector caspase-3 in MCF-7 and MDA-MB-231 cells.	Manganese	52-57	cyclin D1	Homo sapiens	140-149
31584928-9	2019	RESULTS Curcumin reduced cell viability and increased apoptosis of SW620 human colonic adenocarcinoma cells in a dose-dependent way, and increased the expression of CDX2 but decreased ss-catenin nuclear translocation and the expression of Wnt3a, c-Myc, survivin, and cyclin D1.	Curcumin	8-16	cyclin D1	Homo sapiens	267-276
31325197-5	2019	Western blot analysis confirmed that delphinidin treatment can significantly decrease the expression of beta-catenin, glycogen synthase kinase-3beta (Gsk3beta), c-Myc, cyclin-D1, and matrix metalloproteinase-7(MMP-7) expression in breast cancer cells, and inhibition of miR-34a significantly reduced the effect of delphinidin on c-Myc, cyclin-D1, and MMP-7.	delphinidin	37-48	cyclin D1	Homo sapiens	168-177
31342395-11	2019	Finally, the expression of CCND1, a cyclin that forms complexes with CDK4/6 to promote the cell cycle, was the most informative feature in pre-NAC biopsies to predict response to NAC.	nac	143-146	cyclin D1	Homo sapiens	27-32
31342395-11	2019	Finally, the expression of CCND1, a cyclin that forms complexes with CDK4/6 to promote the cell cycle, was the most informative feature in pre-NAC biopsies to predict response to NAC.	nac	179-182	cyclin D1	Homo sapiens	27-32
31545251-7	2019	Realtime-qPCR assay shown that ART decreased the mRNA levels of proliferation related genes c-Myc, cyclin D1 and PCNA, and reduced the mRNA levels of mesenchymal genes N-cadherin, Vimentin and Snail, but increased the mRNA levels of epithelial marker E-cadherin.	Artemisinins	31-34	cyclin D1	Homo sapiens	99-108
31325197-5	2019	Western blot analysis confirmed that delphinidin treatment can significantly decrease the expression of beta-catenin, glycogen synthase kinase-3beta (Gsk3beta), c-Myc, cyclin-D1, and matrix metalloproteinase-7(MMP-7) expression in breast cancer cells, and inhibition of miR-34a significantly reduced the effect of delphinidin on c-Myc, cyclin-D1, and MMP-7.	delphinidin	37-48	cyclin D1	Homo sapiens	336-345
31998463-4	2019	The present study aimed to compare cyclin D1 (CCN D1) gene expression in hepatocellular carcinoma cell line (HUH7) when it is treated with nanomicelle curcumin and sorafenib.	Curcumin	151-159	cyclin D1	Homo sapiens	35-44
31572529-9	2019	Additionally, the Reg3A-mediated upregulation of expression of JAK2, STAT3, NF-kappaBp65 and cyclin D1 was reduced when treated with eckol.	eckol	133-138	cyclin D1	Homo sapiens	93-102
31998463-4	2019	The present study aimed to compare cyclin D1 (CCN D1) gene expression in hepatocellular carcinoma cell line (HUH7) when it is treated with nanomicelle curcumin and sorafenib.	Curcumin	151-159	cyclin D1	Homo sapiens	46-52
31998463-4	2019	The present study aimed to compare cyclin D1 (CCN D1) gene expression in hepatocellular carcinoma cell line (HUH7) when it is treated with nanomicelle curcumin and sorafenib.	sorafenib	164-173	cyclin D1	Homo sapiens	35-44
31998463-4	2019	The present study aimed to compare cyclin D1 (CCN D1) gene expression in hepatocellular carcinoma cell line (HUH7) when it is treated with nanomicelle curcumin and sorafenib.	sorafenib	164-173	cyclin D1	Homo sapiens	46-52
31998463-9	2019	Results: The expression of the CCN D1 gene was statistically significant (P&lt;0.001) at 289.31, 128 and 152.36 for sorafenib, nanomicelle curcumin and SNC (sorafenib-nanomicelle curcumin) respectively.	sorafenib	116-125	cyclin D1	Homo sapiens	31-37
31998463-9	2019	Results: The expression of the CCN D1 gene was statistically significant (P&lt;0.001) at 289.31, 128 and 152.36 for sorafenib, nanomicelle curcumin and SNC (sorafenib-nanomicelle curcumin) respectively.	Curcumin	139-147	cyclin D1	Homo sapiens	31-37
31292999-5	2019	Further, 4"-BR caused a G0/G1 phase arrest of melanoma cells that was accompanied by an increase in WAF-1/P21 and decrease in Cyclin D1/Cyclin-dependent kinase 6 protein levels.	5-(2-(4-bromophenyl)vinyl)-1,3-benzenediol	9-14	cyclin D1	Homo sapiens	126-135
31898689-0	2019	Erratum: Anticancer activity of britannin through the downregulation of cyclin D1 and CDK4 in human breast cancer cells.	britannin	32-41	cyclin D1	Homo sapiens	72-81
31161672-0	2019	Centaurea cyanus extracted 13-O-acetylsolstitialin A decrease Bax/Bcl-2 ratio and expression of cyclin D1/Cdk-4 to induce apoptosis and cell cycle arrest in MCF-7 and MDA-MB-231 breast cancer cell lines.	13-o-acetylsolstitialin	27-50	cyclin D1	Homo sapiens	96-105
31161672-9	2019	Moreover, 13ASA induced cell cycle arrest at subG1 and G1 phases by decreasing protein levels of cyclin D1 and Cdk-4.	13asa	10-15	cyclin D1	Homo sapiens	97-106
31473880-9	2019	Ectopic expression of non-methylatable hnRNP A1 mutants demonstrated that methylation of either arginine residues 218 or 225 was sufficient to maintain IRES binding and hnRNP A1-dependent cyclin D1 or c-MYC IRES activity, however a double R218K/R225K mutant was unable to do so.	Arginine	96-104	cyclin D1	Homo sapiens	188-197
31270151-4	2019	In addition, atovaquone treatment significantly reduced the expression of HER2, beta-catenin and its downstream molecules such as pGSK-3beta, TCF-4, cyclin D1 and c-Myc in vitro.	Atovaquone	13-23	cyclin D1	Homo sapiens	149-158
31270645-9	2019	The LX-2 cells treated with apelin-13 displayed an increased expression of pERK1/2 in a time-dependent manner, while the pretreatment with PD98059 abolished the apelin-induced expression of alpha-SMA and cyclinD1.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	139-146	cyclin D1	Homo sapiens	204-212
31154016-7	2019	Ochratoxin A reduced cell proliferation with sub G0/G1 cell cycle arrest by inhibiting CCND1, CCNE1, CDK4, and MYC expression.	ochratoxin A	0-12	cyclin D1	Homo sapiens	87-92
31383722-5	2019	Accordingly, siRNA oligonucleotides targeted against HuR, YAP1, and their common target cyclin D1, validated the synergy studies.	Oligonucleotides	19-35	cyclin D1	Homo sapiens	88-97
31399647-10	2019	Chromatin immunoprecipitation and DNA affinity precipitation assays showed that ZNF322A phosphorylation defective mutants Thr-150A, Ser-224A, and Thr-234A attenuated chromatin binding and DNA binding affinity to ADD1 and CCND1 promoters compared with wild-type ZNF322A.	Threonine	122-125	cyclin D1	Homo sapiens	221-226
31607309-7	2019	The miR-28-5p target CCND1 was expressed at high levels in MM patients with LPP / miR-28-5p methylation, the expression level of miR-28-5p in MM patients correlated with beta2-MG concentration.	CHEMBL3740941	11-13	cyclin D1	Homo sapiens	21-26
31534470-8	2019	DHA treatment downregulated the angiogenic gene ANGPTL2 and the cell proliferation genes CCND1, E2F1, PCNA, and BCL2.	artenimol	0-3	cyclin D1	Homo sapiens	89-94
31998463-9	2019	Results: The expression of the CCN D1 gene was statistically significant (P&lt;0.001) at 289.31, 128 and 152.36 for sorafenib, nanomicelle curcumin and SNC (sorafenib-nanomicelle curcumin) respectively.	sorafenib	157-166	cyclin D1	Homo sapiens	31-37
31998463-9	2019	Results: The expression of the CCN D1 gene was statistically significant (P&lt;0.001) at 289.31, 128 and 152.36 for sorafenib, nanomicelle curcumin and SNC (sorafenib-nanomicelle curcumin) respectively.	Curcumin	179-187	cyclin D1	Homo sapiens	31-37
31998463-10	2019	The finding of this study revealed that, in comparison to sorafenib alone, the treatment of HUH7 with a nanomicelle curcumin IC50 dose, in combination with sorafenib, might down-regulate CCN D1 gene expression.	Curcumin	116-124	cyclin D1	Homo sapiens	187-193
31998463-10	2019	The finding of this study revealed that, in comparison to sorafenib alone, the treatment of HUH7 with a nanomicelle curcumin IC50 dose, in combination with sorafenib, might down-regulate CCN D1 gene expression.	sorafenib	156-165	cyclin D1	Homo sapiens	187-193
31998463-11	2019	Conclusion: The present research indicates that the treatment of the cell line with only nanomicelle curcumin results in the down-regulation of cyclin D1.	Curcumin	101-109	cyclin D1	Homo sapiens	144-153
31998463-12	2019	To further decrease cyclin D1 expression, the co-delivery of curcumin and sorafenib appears to induce the apoptotic process.	Curcumin	61-69	cyclin D1	Homo sapiens	20-29
31998463-12	2019	To further decrease cyclin D1 expression, the co-delivery of curcumin and sorafenib appears to induce the apoptotic process.	sorafenib	74-83	cyclin D1	Homo sapiens	20-29
31537830-10	2019	The mRNA levels of glutamine synthetase (GLUL), beta-catenin (CTNNB) and its direct target cyclin D1 (CCND1) showed significantly higher expression in the cells grown in low pO2 compared to those grown in high pO2.	PO-2	174-177	cyclin D1	Homo sapiens	91-100
31537830-10	2019	The mRNA levels of glutamine synthetase (GLUL), beta-catenin (CTNNB) and its direct target cyclin D1 (CCND1) showed significantly higher expression in the cells grown in low pO2 compared to those grown in high pO2.	PO-2	174-177	cyclin D1	Homo sapiens	102-107
31537830-10	2019	The mRNA levels of glutamine synthetase (GLUL), beta-catenin (CTNNB) and its direct target cyclin D1 (CCND1) showed significantly higher expression in the cells grown in low pO2 compared to those grown in high pO2.	PO-2	210-213	cyclin D1	Homo sapiens	91-100
31537830-10	2019	The mRNA levels of glutamine synthetase (GLUL), beta-catenin (CTNNB) and its direct target cyclin D1 (CCND1) showed significantly higher expression in the cells grown in low pO2 compared to those grown in high pO2.	PO-2	210-213	cyclin D1	Homo sapiens	102-107
31540454-8	2019	Additionally, cyclin D1 and cyclin E1 were decreased by fludioxonil.	fludioxonil	56-67	cyclin D1	Homo sapiens	14-23
31619992-6	2019	Further investigation revealed that the key proteins (including cyclinD1, cyclinE1, cyclinB1, CDK2, and CDK4) were involved in the cell regulation by NAT-F.	neoantimycin	150-155	cyclin D1	Homo sapiens	64-72
31571914-6	2019	MK2206 and BEZ235 inhibited cell proliferation, enhanced apoptosis, and induced cell-cycle arrest through downstream effectors SKP2, MCL-1, and cyclin D1 in esophageal SCC cells.	MK 2206	0-6	cyclin D1	Homo sapiens	144-153
31571914-6	2019	MK2206 and BEZ235 inhibited cell proliferation, enhanced apoptosis, and induced cell-cycle arrest through downstream effectors SKP2, MCL-1, and cyclin D1 in esophageal SCC cells.	dactolisib	11-17	cyclin D1	Homo sapiens	144-153
31288004-7	2019	beta-Cryptoxanthin treatment induced G0/G1 arrest, and reduced the expression of Cyclin E, Cyclin D1, cyclin-dependent kinases (CDK) of CDK4 and CDK6, and increased the expression of p53 and p21 in the two GC cells.	Beta-Cryptoxanthin	0-18	cyclin D1	Homo sapiens	91-100
31572198-4	2019	In vitro studies showed that TFP induced G0/G1 cell cycle arrest to dramatically inhibit CRC cell proliferation through downregulating cyclin-dependent kinase (CDK) 2, CDK4, cyclin D1, and cyclin E and upregulating p27.	Trifluoperazine	29-32	cyclin D1	Homo sapiens	174-183
31533086-0	2019	Correction for: The combination of lonafarnib and sorafenib induces cyclin D1 degradation via ATG3-mediated autophagic flux in hepatocellular carcinoma cells.	lonafarnib	35-45	cyclin D1	Homo sapiens	68-77
31533086-0	2019	Correction for: The combination of lonafarnib and sorafenib induces cyclin D1 degradation via ATG3-mediated autophagic flux in hepatocellular carcinoma cells.	Sorafenib	50-59	cyclin D1	Homo sapiens	68-77
31460901-13	2019	The expression of p21 (P < 0.05), LC3II/I (P < 0.01), and Beclin 1 (P < 0.01) increased and the expression of cyclin D1 (P < 0.05) decreased with increasing doses of matrine.	matrine	166-173	cyclin D1	Homo sapiens	110-119
31460901-16	2019	Compared with matrine or acitretin group, the expression of p21 (P < 0.05, P < 0.05) and LC3II/I (P < 0.01, P < 0.05) in matrine plus acitretin group increased significantly and the expression of cyclin D1 (P < 0.01, P < 0.05) and p62 (P < 0.05, P < 0.05) was reduced significantly.	matrine	121-128	cyclin D1	Homo sapiens	196-205
31460901-16	2019	Compared with matrine or acitretin group, the expression of p21 (P < 0.05, P < 0.05) and LC3II/I (P < 0.01, P < 0.05) in matrine plus acitretin group increased significantly and the expression of cyclin D1 (P < 0.01, P < 0.05) and p62 (P < 0.05, P < 0.05) was reduced significantly.	Acitretin	134-143	cyclin D1	Homo sapiens	196-205
31484966-5	2019	Cyclin D1 upregulation is observed in human invasive breast cancers, and our findings indicate that dysregulation of T286 phosphorylation could play a role in this phenomenon.	C.I. Basic Blue 54	117-121	cyclin D1	Homo sapiens	0-9
31129716-7	2019	Further, DA was seen to block the G1/S progression and decrease the expression of cyclin D1 in cancer cells.	dinactin	9-11	cyclin D1	Homo sapiens	82-91
31129716-8	2019	Since cyclin D1 is the downstream target gene of Wnt/beta-catenin signaling, we examined the impact of DA on TCF-dependent beta-catenin activity using Top-Flash reporter assay.	dinactin	103-105	cyclin D1	Homo sapiens	6-15
31322047-0	2019	Ara-c induces cell cycle G1/S arrest by inducing upregulation of the INK4 family gene or directly inhibiting the formation of the cell cycle-dependent complex CDK4/cyclin D1.	Cytarabine	0-5	cyclin D1	Homo sapiens	164-173
31322047-8	2019	Moreover, Ara-c-induced cell cycle arrest was found to be associated with an Ara-c-induced upregulation of INK4 family gene expression, which ultimately inhibited the formation of the CDK4/cyclin D1 complex.	Cytarabine	10-15	cyclin D1	Homo sapiens	189-198
31322047-8	2019	Moreover, Ara-c-induced cell cycle arrest was found to be associated with an Ara-c-induced upregulation of INK4 family gene expression, which ultimately inhibited the formation of the CDK4/cyclin D1 complex.	Cytarabine	77-82	cyclin D1	Homo sapiens	189-198
31322047-10	2019	Moreover, Ara-c was shown to promote the upregulation of INK4 family genes, at the same time, Ara-c could directly regulate the cell cycle-dependent genes CDK4 and cyclin D1 (CCND1), independent of the INK4 family genes.	Cytarabine	10-15	cyclin D1	Homo sapiens	164-173
31322047-10	2019	Moreover, Ara-c was shown to promote the upregulation of INK4 family genes, at the same time, Ara-c could directly regulate the cell cycle-dependent genes CDK4 and cyclin D1 (CCND1), independent of the INK4 family genes.	Cytarabine	10-15	cyclin D1	Homo sapiens	175-180
31322047-10	2019	Moreover, Ara-c was shown to promote the upregulation of INK4 family genes, at the same time, Ara-c could directly regulate the cell cycle-dependent genes CDK4 and cyclin D1 (CCND1), independent of the INK4 family genes.	Cytarabine	94-99	cyclin D1	Homo sapiens	164-173
31322047-10	2019	Moreover, Ara-c was shown to promote the upregulation of INK4 family genes, at the same time, Ara-c could directly regulate the cell cycle-dependent genes CDK4 and cyclin D1 (CCND1), independent of the INK4 family genes.	Cytarabine	94-99	cyclin D1	Homo sapiens	175-180
31150783-6	2019	Meanwhile, DMC induced G1 cell cycle arrest through downregulation of cyclin D1 and CDK4.	2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone	11-14	cyclin D1	Homo sapiens	70-79
31912690-5	2019	The effects of AG490 on the expression of STAT3, p-STAT3, MMP2 and Cyclin D1 in Pumc-91 were evaluated using qRT-PCR and Western blot.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	15-20	cyclin D1	Homo sapiens	67-76
31042325-4	2019	In the present study, we showed that curcumin altered the expression of cell cycle-related genes (cyclin D1, PCNA, and p21) and inhibited the proliferation of prostate cancer cells.	Curcumin	37-45	cyclin D1	Homo sapiens	98-107
31528253-6	2019	Results: Thyroxine suppressed the expression of pro-apoptotic BAD but induced proliferative CCND1 expression in SSC-25 cells and OEC-M1 cells.	Thyroxine	9-18	cyclin D1	Homo sapiens	92-97
31288526-10	2019	Significant decreases in the expression of Cyclin D1, beta-Catenin, and c-Myc were observed in the groups that underwent ZOL treatment.	Zoledronic Acid	121-124	cyclin D1	Homo sapiens	43-52
31452795-8	2019	Western blot analysis demonstrated significantly decreased ratios of phosphorylated-AKT/AKT and Bcl-2/Bax, and decreased protein levels of cyclin D1 and CDK4 in cells treated with baicalin.	baicalin	180-188	cyclin D1	Homo sapiens	139-148
31894049-6	2019	S phase arrest induced by hispolon was associated with downregulation of cyclin B1, cyclin D1 and CDK4 while up-regulation of p21.	hispolon	26-34	cyclin D1	Homo sapiens	84-93
31022444-0	2019	Phenylpropanoid-based sulfonamide promotes cyclin D1 and cyclin E down-regulation and induces cell cycle arrest at G1/S transition in estrogen positive MCF-7 cell line.	phenylpropanoid-based sulfonamide	0-33	cyclin D1	Homo sapiens	43-52
31455378-6	2019	Western Blot was performed to detect the expressions of AMPKalpha, Yap1, CCND1, CCNE1/2 and CDK2/4/6 in the metformin-treated BLCA cell lines.	Metformin	108-117	cyclin D1	Homo sapiens	73-78
31455378-12	2019	And metformin upregulated the phosphorylated AMPKalpha and decreased the expressions of Yap1 and CCND1, CCNE1/2 and CDK4/6.	Metformin	4-13	cyclin D1	Homo sapiens	97-102
31238027-6	2019	Menadione decreased TOPFlash/FOPFlash luciferase activity and expression of several downstream targets of Wnt signaling and coactivators such as beta-catenin (CTNNB1), TCF7L2, Bcl9l, p300 (EP300) and cyclin D1 (CCND1) was suppressed.	Vitamin K 3	0-9	cyclin D1	Homo sapiens	200-209
31238027-6	2019	Menadione decreased TOPFlash/FOPFlash luciferase activity and expression of several downstream targets of Wnt signaling and coactivators such as beta-catenin (CTNNB1), TCF7L2, Bcl9l, p300 (EP300) and cyclin D1 (CCND1) was suppressed.	Vitamin K 3	0-9	cyclin D1	Homo sapiens	211-216
31116586-0	2019	Everolimus induces G1 cell cycle arrest through autophagy-mediated protein degradation of cyclin D1 in breast cancer cells.	Everolimus	0-10	cyclin D1	Homo sapiens	90-99
31438640-6	2019	We found that fisetin significantly inhibited cell viability through cell cycle arrest in the G2/M phase, in addition to downregulating cyclin D1 and upregulating p21/p27.	fisetin	14-21	cyclin D1	Homo sapiens	136-145
31426282-4	2019	Interestingly, Pyrogallol induced S-phase arrest and attenuated the protein expression of CyclinD1, Cyclin E, Cyclin A, c-Myc, S-phase kinase-associated protein 2 (Skp2), p-AKT, PI3K, increased the protein expression of p27, and also reduced the fluorescent expression of Cyclin E in Hep3B and Huh7 cells.	Pyrogallol	15-25	cyclin D1	Homo sapiens	90-98
31426282-6	2019	Notably, Pyrogallol upregulated miRNA levels of miR-134, and conversely, miR-134 inhibition rescued the decreased expression levels of c-Myc, Cyclin E, and Cyclin D1 and increased the expression of p27 by Pyrogallol in Huh7 cells.	Pyrogallol	9-19	cyclin D1	Homo sapiens	156-165
31497196-6	2019	Moreover, target prediction and luciferase reporter assay demonstrated that miR-16-5p could negatively regulate Bcl-2 and Cyclin-D1 expression.	mir-16-5p	76-85	cyclin D1	Homo sapiens	122-131
31409760-0	2019	The combination of lonafarnib and sorafenib induces cyclin D1 degradation via ATG3-mediated autophagic flux in hepatocellular carcinoma cells.	lonafarnib	19-29	cyclin D1	Homo sapiens	52-61
31409760-0	2019	The combination of lonafarnib and sorafenib induces cyclin D1 degradation via ATG3-mediated autophagic flux in hepatocellular carcinoma cells.	Sorafenib	34-43	cyclin D1	Homo sapiens	52-61
31426542-2	2019	Herein, we demonstrate that hydroxyprogesterone (OHPg) through progesterone receptor B (PR-B) reduces breast cancer cell aggressiveness, by targeting the cytoplasmic CD1.	Hydroxyprogesterones	28-47	cyclin D1	Homo sapiens	166-169
31116586-3	2019	We, for the first time, suggested that everolimus could stimulate autophagy-mediated cyclin D1 degradation in breast cancer cells.	Everolimus	39-49	cyclin D1	Homo sapiens	85-94
31116586-4	2019	Everolimus-induced cyclin D1 degradation through the autophagy pathway was investigated in MCF-10DCIS.COM and MCF-7 cell lines upon autophagy inhibitor treatment using Western blot assay.	Everolimus	0-10	cyclin D1	Homo sapiens	19-28
31116586-5	2019	Everolimus-stimulated autophagy and decrease in cyclin D1 were also tested in explant human breast tissue.	Everolimus	0-10	cyclin D1	Homo sapiens	48-57
31116586-6	2019	Inhibiting mTORC1 with everolimus rapidly increased cyclin D1 degradation, whereas 3-methyladenine, chloroquine, and bafilomycin A1, the classic autophagy inhibitors, could attenuate everolimus-induced cyclin D1 degradation.	Everolimus	23-33	cyclin D1	Homo sapiens	52-61
31116586-6	2019	Inhibiting mTORC1 with everolimus rapidly increased cyclin D1 degradation, whereas 3-methyladenine, chloroquine, and bafilomycin A1, the classic autophagy inhibitors, could attenuate everolimus-induced cyclin D1 degradation.	3-methyladenine	83-98	cyclin D1	Homo sapiens	202-211
31116586-6	2019	Inhibiting mTORC1 with everolimus rapidly increased cyclin D1 degradation, whereas 3-methyladenine, chloroquine, and bafilomycin A1, the classic autophagy inhibitors, could attenuate everolimus-induced cyclin D1 degradation.	bafilomycin A1	117-131	cyclin D1	Homo sapiens	202-211
31116586-7	2019	Similarly, knockdown of autophagy-related 7 (Atg-7) also repressed everolimus-triggered cyclin D1 degradation.	Everolimus	67-77	cyclin D1	Homo sapiens	88-97
31116586-9	2019	We also found that everolimus stimulated autophagy and decreased cyclin D1 levels in explant human breast tissue.	Everolimus	19-29	cyclin D1	Homo sapiens	65-74
31116586-10	2019	These data support the conclusion that the autophagy induced by everolimus in human mammary epithelial cells appears to cause cyclin D1 degradation resulting in G1 cell cycle arrest.	Everolimus	64-74	cyclin D1	Homo sapiens	126-135
31016752-7	2019	Additionally, we confirmed 0.1 mum BBP-induced cell proliferation caused the arrest of cells in S phase and inhibited apoptosis, which might be partially explained by the decreased expression of p53, the increased expression of proliferating cell nuclear antigen, Bcl-2 and cell cycle regulator cyclin-D1, and the activation of aromatase.	butylbenzyl phthalate	35-38	cyclin D1	Homo sapiens	295-304
31078603-5	2019	The mechanistic study elucidated that the Fe(II) complex caused cell cycle arrest at the G0/G1 phase by blocking the CDK4/6-cyclin D1 complex and induced mitochondria-mediated apoptosis.	ammonium ferrous sulfate	42-48	cyclin D1	Homo sapiens	124-133
31143889-7	2019	Importantly, treatment with TUDCA at sub-micellar concentrations (2500 muM) significantly increased cell proliferation and Cyclin D1 expression compared with the controls.	ursodoxicoltaurine	28-33	cyclin D1	Homo sapiens	123-132
31042404-5	2019	NHERF1 knockdown fully abrogated the ISO-, PGE2-, and FSK-induced IL-6 gene expression and cytokine production without affecting cAMP-mediated phosphodiesterase 4D (PDE4D) gene expression, phospho-cAMP response element-binding protein (p-CREB), and cAMP response element (CRE)-Luc, or PDGF-induced cyclin D1 expression.	Colforsin	54-57	cyclin D1	Homo sapiens	298-307
30859584-4	2019	Western blot analysis showed the protein level of ERK, phosphorylated ERK, cyclin D1 (CCND1), and cyclin-dependent kinase 2 (CDK2) increased after stimulation with RA, and this effect could also be abolished by U0126.	Tretinoin	164-166	cyclin D1	Homo sapiens	75-84
30859584-4	2019	Western blot analysis showed the protein level of ERK, phosphorylated ERK, cyclin D1 (CCND1), and cyclin-dependent kinase 2 (CDK2) increased after stimulation with RA, and this effect could also be abolished by U0126.	Tretinoin	164-166	cyclin D1	Homo sapiens	86-91
30536619-6	2019	Additionally, miR-16-5p specifically targeted the Cyclin D1/E1-3"-UTR in LNCaP cells and affected the expression of Cyclin D1/E1 in both mRNA and protein levels.	mir-16-5p	14-23	cyclin D1	Homo sapiens	50-59
30536619-6	2019	Additionally, miR-16-5p specifically targeted the Cyclin D1/E1-3"-UTR in LNCaP cells and affected the expression of Cyclin D1/E1 in both mRNA and protein levels.	mir-16-5p	14-23	cyclin D1	Homo sapiens	116-125
30536619-7	2019	Taken together, miR-16-5p enhanced radiosensitivity of CaP cells, the mechanism may be through modulating Cyclin D1/Cyclin E1/pRb/E2F1 pathway to cause cell cycle arrest at G0/G1 phase.	mir-16-5p	16-25	cyclin D1	Homo sapiens	106-115
30536619-8	2019	These findings provided new insight into the correlation between miR-16-5p, cell cycle arrest, and radiosensitivity in CaP, revealed a previously unrecognized function of miR-16-5p-Cyclin D1/E1-pRb-E2F1 regulation in response to IR and may offer an alternative therapy to improve the efficiency of conventional radiotherapy.	mir-16-5p	65-74	cyclin D1	Homo sapiens	181-190
31741457-9	2019	Lycopene induces apoptosis by reducing ROS levels and suppressing beta-catenin-c-myc/cyclin D1 axis.	Lycopene	0-8	cyclin D1	Homo sapiens	85-94
31189612-6	2019	Mechanistically, vorinostat reverted 5FU/CDDP-induced EGFR phosphorylation and nuclear translocation, leading to the impairment of nuclear EGFR noncanonical induction of genes such as thymidylate synthase and cyclin D1.	Vorinostat	17-27	cyclin D1	Homo sapiens	209-218
30859584-4	2019	Western blot analysis showed the protein level of ERK, phosphorylated ERK, cyclin D1 (CCND1), and cyclin-dependent kinase 2 (CDK2) increased after stimulation with RA, and this effect could also be abolished by U0126.	U 0126	211-216	cyclin D1	Homo sapiens	75-84
30911957-6	2019	Berberine decreased the expression of protein levels of cyclin D1, cyclin E, CDK2, CDK4, and CDK6 to cause G1 phase arrest.	Berberine	0-9	cyclin D1	Homo sapiens	56-65
31189612-6	2019	Mechanistically, vorinostat reverted 5FU/CDDP-induced EGFR phosphorylation and nuclear translocation, leading to the impairment of nuclear EGFR noncanonical induction of genes such as thymidylate synthase and cyclin D1.	Fluorouracil	37-40	cyclin D1	Homo sapiens	209-218
30859584-4	2019	Western blot analysis showed the protein level of ERK, phosphorylated ERK, cyclin D1 (CCND1), and cyclin-dependent kinase 2 (CDK2) increased after stimulation with RA, and this effect could also be abolished by U0126.	U 0126	211-216	cyclin D1	Homo sapiens	86-91
31423185-8	2019	Consistent with the observed growth inhibitory effects, BPs also inhibited the cell cycle by promoting G1 phase arrest and the downregulation of cyclin D1 and upregulation of p21.	Diphosphonates	56-59	cyclin D1	Homo sapiens	145-154
31555522-13	2019	Under hypoxic conditions, apatinib could not inhibit the protein expression of VEGFR and HIF-alpha in both cell lines; however, apatinib decreased the expression of cyclin D1 and P53 significantly.	apatinib	128-136	cyclin D1	Homo sapiens	165-174
30940290-8	2019	Our data suggested that siRNA-TMEM168 (siTMEM168) prevented viability of U87 and U373 cells, induced cell cycle arrest (G0/G1 phase) and promoted apoptosis, and the mechanisms involved in blocking Wnt/beta-catenin pathway, as evidenced by reducing expression of beta-catenin, C-myc, cyclin D1, and survivin.	sitmem168	39-48	cyclin D1	Homo sapiens	283-292
31396349-11	2019	In addition, in MCF-7 cells, Apatinib decreased AMOT expression, accompanied with the decreased expression of LATS1/2, YAP, ERK1/2 phosphorylation and cyclin D1.	apatinib	29-37	cyclin D1	Homo sapiens	151-160
31341363-9	2019	Also, RA decreased protein expression of Wee1, while the combinational effect of RA and 5-Fu decreased protein expressions of cyclooxygenase-2, B cell lymphoma 2, and Wee1 but increased protein levels of Bax, cyclin D1, and cyclin E. CONCLUSION: Taken together, the results suggest that RA acts as an anti-cancer agent and enhancer of 5-Fu in bile duct cancer cells via regulating multiple cell cycle and apoptosis-related proteins.	raddeanin A	81-83	cyclin D1	Homo sapiens	209-218
31341363-9	2019	Also, RA decreased protein expression of Wee1, while the combinational effect of RA and 5-Fu decreased protein expressions of cyclooxygenase-2, B cell lymphoma 2, and Wee1 but increased protein levels of Bax, cyclin D1, and cyclin E. CONCLUSION: Taken together, the results suggest that RA acts as an anti-cancer agent and enhancer of 5-Fu in bile duct cancer cells via regulating multiple cell cycle and apoptosis-related proteins.	Fluorouracil	88-92	cyclin D1	Homo sapiens	209-218
31341363-9	2019	Also, RA decreased protein expression of Wee1, while the combinational effect of RA and 5-Fu decreased protein expressions of cyclooxygenase-2, B cell lymphoma 2, and Wee1 but increased protein levels of Bax, cyclin D1, and cyclin E. CONCLUSION: Taken together, the results suggest that RA acts as an anti-cancer agent and enhancer of 5-Fu in bile duct cancer cells via regulating multiple cell cycle and apoptosis-related proteins.	raddeanin A	81-83	cyclin D1	Homo sapiens	209-218
31063955-7	2019	RESULTS: The flow cytometry and western blot results indicated that compared to TPL or HCPT treatment alone, combination treatment of HCPT and TPL significantly induced cell cycle arrest at the G1 phase via suppressing CDK4, CDK6 and CyclinD1 in the EJ and UMUC3 bladder cancer cell lines.	hydroxycamptothecinum	134-138	cyclin D1	Homo sapiens	234-242
31189612-6	2019	Mechanistically, vorinostat reverted 5FU/CDDP-induced EGFR phosphorylation and nuclear translocation, leading to the impairment of nuclear EGFR noncanonical induction of genes such as thymidylate synthase and cyclin D1.	cddp	41-45	cyclin D1	Homo sapiens	209-218
31277690-7	2019	Psoralen induces cell cycle arrest at G1 phase by enhancing CyclinD1 and reducing CyclinE1 expression.	Ficusin	0-8	cyclin D1	Homo sapiens	60-68
31078043-4	2019	In addition, we found that overexpression of miR-128-3p arrested breast cancer cells in G0/G1 phase by affecting expression of CDK4/CDK6/Cyclin D1 and CDK2/Cyclin E1.	mir-128-3p	45-55	cyclin D1	Homo sapiens	137-146
31063955-7	2019	RESULTS: The flow cytometry and western blot results indicated that compared to TPL or HCPT treatment alone, combination treatment of HCPT and TPL significantly induced cell cycle arrest at the G1 phase via suppressing CDK4, CDK6 and CyclinD1 in the EJ and UMUC3 bladder cancer cell lines.	triptolide	143-146	cyclin D1	Homo sapiens	234-242
31189128-3	2019	In this study, we provided evidence that 17beta-estradiol (E2) could significantly promote endometrial cancer cells viability, migration and invasion through activation of IL-6 pathway, which involved in its downstream pathway and target genes (p-Stat3, Bcl-2, Mcl-1, CyclinD1 and MMP2).	Estradiol	41-57	cyclin D1	Homo sapiens	268-276
31239643-12	2019	Furthermore, notopterol induced the G0/G1 cell-cycle arrest as determined using flow cytometry, which may be related to the regulation of cell-cycle-related proteins p53, CDK2, CDK4, Cyclin D1, Cyclin E, and survivin.	notopterol	13-23	cyclin D1	Homo sapiens	183-192
31219365-5	2019	Expert opinion: The cyclin D1 gene encodes the regulatory subunit of a proline-directed serine-threonine kinase that phosphorylates several substrates.	Proline	71-78	cyclin D1	Homo sapiens	20-29
31219365-5	2019	Expert opinion: The cyclin D1 gene encodes the regulatory subunit of a proline-directed serine-threonine kinase that phosphorylates several substrates.	Serine	88-94	cyclin D1	Homo sapiens	20-29
31059018-6	2019	Notably, KYS05090S attenuated the expression of anti-apoptotic proteins, including cyclin D1 and B-cell lymphoma-2 (Bcl-2), and reduced the phosphorylation of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) in ovarian cancer cells.	KYS 05090	9-18	cyclin D1	Homo sapiens	83-92
30585634-8	2019	In the core signaling pathways of GBM, nano micelles curcumin either significantly influences the NF-kappaB pathway by decreasing p-65 expression or significantly inhibits the Wnt/beta-catenin pathway by declining cyclin D1 expression.	Curcumin	53-61	cyclin D1	Homo sapiens	214-223
31603118-0	2019	Anticancer activity of britannin through the downregulation of cyclin D1 and CDK4 in human breast cancer cells.	britannin	23-32	cyclin D1	Homo sapiens	63-72
31603118-6	2019	The effects of britannin on cyclin D1 and CDK4 expression were evaluated using the Western blot.	britannin	15-24	cyclin D1	Homo sapiens	28-37
31603118-8	2019	Reduction of cyclin D1 and CDK4 protein levels were also observed after treating cancer cells with britannin.	britannin	99-108	cyclin D1	Homo sapiens	13-22
31603118-9	2019	Conclusion: The obtained results reveal that britannin can inhibit MCF-7 and MDA-MB-468 breast cancer cells proliferation through arresting cell cycle progression through cyclin D1/CDK4-mediated pathway.	britannin	45-54	cyclin D1	Homo sapiens	171-180
31646826-11	2019	Esculetin also triggered G0/G1 cell cycle arrest in HL-60 cells, which was also accompanied by suppression of Cyclin D1 and D3.	esculetin	0-9	cyclin D1	Homo sapiens	110-119
31289542-6	2019	The expression of EGFR and STAT3 was downregulated following TSA treatment, and cell cycle arrest was induced by downregulating the expression of cyclin D1 and CDK6, and via retinoblastoma protein phosphorylation.	trichostatin A	61-64	cyclin D1	Homo sapiens	146-155
31289542-7	2019	Furthermore, the transcription of cyclin D1 and CDK6 was suppressed by TSA.	trichostatin A	71-74	cyclin D1	Homo sapiens	34-43
31078367-0	2019	Tylophorine reduces protein biosynthesis and rapidly decreases cyclin D1, inhibiting vascular smooth muscle cell proliferation in vitro and in organ culture.	tylophorine	0-11	cyclin D1	Homo sapiens	63-72
31078367-12	2019	TYL also decreased levels of p21 and p27 proteins, although at later time points than observed for cyclin D1.	tylophorine	0-3	cyclin D1	Homo sapiens	99-108
31078367-14	2019	Comparable time-dependent downregulation of cyclin D1, p21 and p27 in TYL- or CHX-treated cells, together with decreased protein synthesis observed in the Click-iT assay, suggests that TYL is a protein synthesis inhibitor.	tylophorine	70-73	cyclin D1	Homo sapiens	44-53
31078367-14	2019	Comparable time-dependent downregulation of cyclin D1, p21 and p27 in TYL- or CHX-treated cells, together with decreased protein synthesis observed in the Click-iT assay, suggests that TYL is a protein synthesis inhibitor.	tylophorine	185-188	cyclin D1	Homo sapiens	44-53
31250221-7	2019	Further, Qu (0.12%) + TiO2 (15%) nanogel significantly (p &lt; 0.001) downregulated COX-2, EP3, EP4, PCNA, and cyclin D1 expressions in contrast to Qu and TiO2 only pretreated groups.	titanium dioxide	22-26	cyclin D1	Homo sapiens	111-120
31238539-8	2019	After regorafenib treatment, downregulation of related genes in invasion (vascular endothelial growth factor (VEGF) and matrix metallopeptidase 9 (MMP-9)), proliferation (CyclinD1) and anti-apoptosis (X-linked inhibitor of apoptosis protein (XIAP), myeloid cell leukemia-1 (MCL-1), and cellular FLICE (FADD-like IL-1beta-converting enzyme)-inhibitory protein (C-FLIP)) were found.	regorafenib	6-17	cyclin D1	Homo sapiens	171-179
30837032-10	2019	Thus, the transcription of cyclin D1, c-Myc, and LEF/TCF was reduced, which synergistically inhibited cell proliferation, enhanced BZM-induced apoptosis, and promoted BZM-induced cell cycle arrest in myeloma cells.	Bortezomib	131-134	cyclin D1	Homo sapiens	27-36
30837032-10	2019	Thus, the transcription of cyclin D1, c-Myc, and LEF/TCF was reduced, which synergistically inhibited cell proliferation, enhanced BZM-induced apoptosis, and promoted BZM-induced cell cycle arrest in myeloma cells.	Bortezomib	167-170	cyclin D1	Homo sapiens	27-36
30878387-5	2019	Western blotting demonstrated that tanshinone I inhibited the expression of proliferation-related proteins, including cyclin-dependent kinase 4 (CDK4), cyclin D3, and cyclin D1, in a dose-dependent manner.	tanshinone	35-47	cyclin D1	Homo sapiens	167-176
31196027-10	2019	In the following experiments, we found that CDCA2 regulated CCND1 expression through activating the PI3K/AKT pathway, and confirmed this using a specific PI3K inhibitor (LY294002).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	170-178	cyclin D1	Homo sapiens	60-65
31235998-18	2019	Western blotting showed that upregulation of miR-34a combined with treatment with doxorubicin caused significant changes in the expression levels of p-p53, SIRT1, cyclin D1, CDK4, CDK6, BCL-2, MDR1/P-gp and AXL proteins (P &lt; 0.01).	Doxorubicin	82-93	cyclin D1	Homo sapiens	163-172
28963442-5	2019	In addition, acrylamide reduced the PTEN expression in protein level, while induced the expressions of p-AKT, EGFR and cyclin D1.	Acrylamide	13-23	cyclin D1	Homo sapiens	119-128
30693973-9	2019	Further experiments showed that administration of rEGFL6 to cell cultures with EGFL6 knocked down or treated with the WNT/beta-catenin inhibitor ICG-001 increased beta-catenin and its downstream protein CyclinD1.	ICG 001	145-152	cyclin D1	Homo sapiens	203-211
31656498-2	2019	Objectives: The aim of this study was to relate the Cyclin D1 protein overexpression with the amplification of its gene CCND1 in Estrogen Receptors (ER) positive breast carcinomas, in order to investigate the prognostic effect of their aberrations in relation to ER status, also to correlate the Cyclin D1 overexpression with other prognostic parameters.	Estrogens	129-137	cyclin D1	Homo sapiens	52-61
31656498-2	2019	Objectives: The aim of this study was to relate the Cyclin D1 protein overexpression with the amplification of its gene CCND1 in Estrogen Receptors (ER) positive breast carcinomas, in order to investigate the prognostic effect of their aberrations in relation to ER status, also to correlate the Cyclin D1 overexpression with other prognostic parameters.	Estrogens	129-137	cyclin D1	Homo sapiens	120-125
31656498-2	2019	Objectives: The aim of this study was to relate the Cyclin D1 protein overexpression with the amplification of its gene CCND1 in Estrogen Receptors (ER) positive breast carcinomas, in order to investigate the prognostic effect of their aberrations in relation to ER status, also to correlate the Cyclin D1 overexpression with other prognostic parameters.	Estrogens	129-137	cyclin D1	Homo sapiens	296-305
31656498-3	2019	Materials and methods: Chromogenic in situ hybridization (CISH) was used to identify CCND1 amplification on formalin-fixed paraffin-embedded invasive ductal carcinoma, in which immunohistochemistry (IHC) had previously been performed in order to evaluate the pathological relevance of Cyclin D1 overexpression in human breast cancer (n = 138).	Formaldehyde	108-116	cyclin D1	Homo sapiens	85-90
31244286-0	2019	Metformin Modulates Cyclin D1 and P53 Expression to Inhibit Cell Proliferation and to Induce Apoptosis in Cervical Cancer Cell Lines.	Metformin	0-9	cyclin D1	Homo sapiens	20-29
31244286-4	2019	Thisstudy aimed to investigate the effect of metfomin on expression of cyclin D1 and p53 and apoptosis in HeLa cancer cellline.	metfomin	45-53	cyclin D1	Homo sapiens	71-80
31244286-14	2019	Conclusion: Metformin can modulate cyclin D1 and p53 expression in HeLa cancer cell line, leadingto inhibition of cell proliferation and induction of apoptosis.	Metformin	12-21	cyclin D1	Homo sapiens	35-44
30930425-0	2019	Ginsenoside Rg3 Combined with Oxaliplatin Inhibits the Proliferation and Promotes Apoptosis of Hepatocellular Carcinoma Cells via Downregulating PCNA and Cyclin D1.	ginsenoside Rg3	0-15	cyclin D1	Homo sapiens	154-163
30930425-0	2019	Ginsenoside Rg3 Combined with Oxaliplatin Inhibits the Proliferation and Promotes Apoptosis of Hepatocellular Carcinoma Cells via Downregulating PCNA and Cyclin D1.	Oxaliplatin	30-41	cyclin D1	Homo sapiens	154-163
30930425-6	2019	Meanwhile, ginsenoside Rg3, oxaliplatin or ginsenoside Rg3 + oxaliplatin also significantly inhibited the expressions of PCNA and cyclin D1.	ginsenoside Rg3	11-26	cyclin D1	Homo sapiens	130-139
30930425-6	2019	Meanwhile, ginsenoside Rg3, oxaliplatin or ginsenoside Rg3 + oxaliplatin also significantly inhibited the expressions of PCNA and cyclin D1.	Oxaliplatin	28-39	cyclin D1	Homo sapiens	130-139
30930425-6	2019	Meanwhile, ginsenoside Rg3, oxaliplatin or ginsenoside Rg3 + oxaliplatin also significantly inhibited the expressions of PCNA and cyclin D1.	ginsenoside Rg3	43-58	cyclin D1	Homo sapiens	130-139
30930425-6	2019	Meanwhile, ginsenoside Rg3, oxaliplatin or ginsenoside Rg3 + oxaliplatin also significantly inhibited the expressions of PCNA and cyclin D1.	Oxaliplatin	61-72	cyclin D1	Homo sapiens	130-139
30930425-8	2019	Taken together, cells treated with oxaliplatin+ ginsenoside enhanced the anti-tumor effect and may inhibit the proliferation and promoted apoptosis of hepatocellular carcinoma via regulating the expression of PCNA and cyclin D1.	Oxaliplatin	35-46	cyclin D1	Homo sapiens	218-227
30930425-8	2019	Taken together, cells treated with oxaliplatin+ ginsenoside enhanced the anti-tumor effect and may inhibit the proliferation and promoted apoptosis of hepatocellular carcinoma via regulating the expression of PCNA and cyclin D1.	Ginsenosides	48-59	cyclin D1	Homo sapiens	218-227
30801954-6	2019	Our results demonstrated NF-kappaB activation and protein levels of MMP-9, XIAP, VEGF, and Cyclin-D1 were significantly reduced by NF-kappaB (QNZ), ERK (PD98059), and P38 (SB203580) inhibitors.	SB 203580	172-180	cyclin D1	Homo sapiens	91-100
31105786-10	2019	Simvastatin treatment induced cell cycle arrest in the G1 phase in C666-1 cells by inhibiting the expression of cyclin D1 and cyclin-dependent kinase 4, and enhancing p27 expression.	Simvastatin	0-11	cyclin D1	Homo sapiens	112-121
31338250-9	2019	Significant decrease occurred in cyclin D1 expression by Dox NPs and HP NPs (P &lt; 0.05).	Doxorubicin	57-60	cyclin D1	Homo sapiens	33-42
31338250-10	2019	Exposure of KYSE-30 cells to combined treatments including both Dox and HP extract significantly increased the level of cyclin D1 expression as compared to those with individual treatments (P &lt; 0.05).	Doxorubicin	64-67	cyclin D1	Homo sapiens	120-129
31338250-10	2019	Exposure of KYSE-30 cells to combined treatments including both Dox and HP extract significantly increased the level of cyclin D1 expression as compared to those with individual treatments (P &lt; 0.05).	histidylproline	72-74	cyclin D1	Homo sapiens	120-129
31338250-11	2019	Conclusion: Dox NPs and HP NPs can successfully and specifically target ESCC cells through downregulation of cyclin D1.	Doxorubicin	12-15	cyclin D1	Homo sapiens	109-118
31228347-9	2019	Moreover, diosmetin treatment significantly downregulated the expression levels of Bcl-2 and Cyclin D1, and upregulated that of p53, Bax, caspase 3, cleaved caspase 9, and cleaved caspase 3.	diosmetin	10-19	cyclin D1	Homo sapiens	93-102
31206033-9	2019	Finally, miR-107 could further reduce the decreased expression of TPD52, Wnt1, beta-catenin and cyclin D1 that was induced by PTX in both mRNA and protein levels, which were rescued by pcDNA3.1-TPD52 indicating that miR-107 regulated breast cancer cell sensitivity to PTX may be targeting TPD52 through Wnt/beta-catenin signaling pathway.	Paclitaxel	126-129	cyclin D1	Homo sapiens	96-105
31206033-9	2019	Finally, miR-107 could further reduce the decreased expression of TPD52, Wnt1, beta-catenin and cyclin D1 that was induced by PTX in both mRNA and protein levels, which were rescued by pcDNA3.1-TPD52 indicating that miR-107 regulated breast cancer cell sensitivity to PTX may be targeting TPD52 through Wnt/beta-catenin signaling pathway.	Paclitaxel	268-271	cyclin D1	Homo sapiens	96-105
30958912-12	2019	Furthermore, the activation of the cGMP/PKG pathway inhibited CCL5 secretion by CD8 + T cells by downregulating nuclear factor-kappaB p65 phosphorylation, which reduced the growth of BPH-1 through CCL5/STAT5/CCND1 signaling.	Cyclic GMP	35-39	cyclin D1	Homo sapiens	208-213
31004883-11	2019	Finally, proliferation markers including cyclin D1 and c-Myc, and anti-apoptosis proteins such as Bcl-2 and survivin were also down-regulated by PAB treatment in HepG2 cells.	pseudolaric acid B	145-148	cyclin D1	Homo sapiens	41-50
30244336-10	2019	Western blot and RT-PCR studies showed that only the LARP1 and CCND1 genes were over-expressed up to 2-5 times in all paclitaxel-resistant cell lines compared to the other investigated genes.	Paclitaxel	118-128	cyclin D1	Homo sapiens	63-68
30935902-6	2019	The inhibitory effect of curcumin, piperine and vitamin E on cell proliferation involves different markers, and in particular inhibits beta-catenin, cyclinD1 and p53, making them candidates for a possible use in alternative therapies although further studies are needed.	Curcumin	25-33	cyclin D1	Homo sapiens	149-157
31138777-7	2019	Mechanistically, by upregulating the expression of cAMP response element-binding protein (CREB1) and its downstream targets, such as cyclin D1 and MMP-9, the effects of the HBx-CTTN interaction on the enhancement of cellular proliferation and migration were maintained by inhibiting cell cycle arrest.	Cyclic AMP	51-55	cyclin D1	Homo sapiens	133-142
30935902-6	2019	The inhibitory effect of curcumin, piperine and vitamin E on cell proliferation involves different markers, and in particular inhibits beta-catenin, cyclinD1 and p53, making them candidates for a possible use in alternative therapies although further studies are needed.	piperine	35-43	cyclin D1	Homo sapiens	149-157
30935902-6	2019	The inhibitory effect of curcumin, piperine and vitamin E on cell proliferation involves different markers, and in particular inhibits beta-catenin, cyclinD1 and p53, making them candidates for a possible use in alternative therapies although further studies are needed.	Vitamin E	48-57	cyclin D1	Homo sapiens	149-157
31211239-2	2019	Recent work reveals that dysregulation of F-Box Protein 4 (FBXO4)-Cyclin D1 axis leads to mitochondrial dysfunction and drives glutamine-addiction in esophageal squamous cell carcinoma.	Glutamine	127-136	cyclin D1	Homo sapiens	66-75
31213891-7	2019	At 48 hours, E2+Dox had induced a significant increase in the percentage of sub-G1 apoptotic cells, increased CHK1 expression, and decreased cyclin D1, CDK4, and CDK6 expression.	Doxorubicin	16-19	cyclin D1	Homo sapiens	141-150
31026007-4	2019	beta-Thujaplicin induced G0/G1 phase cell cycle arrest and regulated cell cycle mediators, cyclin D1, cyclin E, and cyclin-dependent kinase 4 (CDK 4), leading to the inhibition of the proliferation of ER-negative basal-like MCF10DCIS.com human breast cancer cells.	beta-thujaplicin	0-16	cyclin D1	Homo sapiens	91-100
31040202-12	2019	Therefore, we conclude that Tet and the CCND1/CDK4 compound could form hydrogen bonds and a stable compound structure, which can inhibit colon cancer cells proliferation by regulating CCND1/CDK4 compound and its downstream proteins phosphorylated Rb (p-Rb).	tetrandrine	28-31	cyclin D1	Homo sapiens	184-189
31040202-12	2019	Therefore, we conclude that Tet and the CCND1/CDK4 compound could form hydrogen bonds and a stable compound structure, which can inhibit colon cancer cells proliferation by regulating CCND1/CDK4 compound and its downstream proteins phosphorylated Rb (p-Rb).	Hydrogen	71-79	cyclin D1	Homo sapiens	40-45
31040202-12	2019	Therefore, we conclude that Tet and the CCND1/CDK4 compound could form hydrogen bonds and a stable compound structure, which can inhibit colon cancer cells proliferation by regulating CCND1/CDK4 compound and its downstream proteins phosphorylated Rb (p-Rb).	Hydrogen	71-79	cyclin D1	Homo sapiens	184-189
31191746-8	2019	Western blot detection showed that CCND1 and phosphorylated Rb transcriptional corepressor 1 at ser-807/811 (pRb1-ser807/811) expression levels were downregulated when NFE2L3 was inhibited in those two cell lines.	Serine	96-99	cyclin D1	Homo sapiens	35-40
30420719-6	2019	Suppression of cap-dependent translation by 4EGI-1 resulted in diminished expression of oncogenic proteins c-Myc, Bcl-2, cyclin D1, and survivin, whereas beta-actin expression was left unchanged.	cap	15-18	cyclin D1	Homo sapiens	121-130
30424705-5	2019	In addition, the combination of Vorinostat and Palbociclib significantly inhibited the activation of the key molecules of the CDK4/6-Rb pathway and HDAC activity and subsequently decreased the expression of Cyclin-D1 and Bcl-2.	Vorinostat	32-42	cyclin D1	Homo sapiens	207-216
30794351-6	2019	Exposure to 8:2 FTOH inhibited the mRNA expression of cell cycle-related genes, including CCNA1, CCNA2, CCND1, and CCNE2.	Fluorocarbons	16-20	cyclin D1	Homo sapiens	104-109
30424705-5	2019	In addition, the combination of Vorinostat and Palbociclib significantly inhibited the activation of the key molecules of the CDK4/6-Rb pathway and HDAC activity and subsequently decreased the expression of Cyclin-D1 and Bcl-2.	palbociclib	47-58	cyclin D1	Homo sapiens	207-216
30896878-4	2019	CsA treatment increased the phosphorylation of protein kinase B (Akt) and consequently the expression of Cyclin D1.	Cyclosporine	0-3	cyclin D1	Homo sapiens	105-114
29251999-5	2019	Among them, compound 15beta-hydroxy-20(R)-panaxatriol (4) exhibited selective inhibitory effects on human leukaemic progenitor cells K562/ADR through arresting cell cycle, which was associated with obvious decrease of cyclin B1, cyclin D1 and cyclin-dependent kinase (CDK) 1/2/4/6 protein expression.	15beta-hydroxy-20(r)-panaxatriol	21-53	cyclin D1	Homo sapiens	229-238
30896878-6	2019	Mechanistically, CsA treatment increased reactive oxygen species (ROS) generation, and the intracellular ROS scavenger N-acetyl-cysteine (NAC) attenuated CsA-induced cell proliferation as well as the activation of Akt/Cyclin D1 signaling.	Reactive Oxygen Species	105-108	cyclin D1	Homo sapiens	218-227
30896878-6	2019	Mechanistically, CsA treatment increased reactive oxygen species (ROS) generation, and the intracellular ROS scavenger N-acetyl-cysteine (NAC) attenuated CsA-induced cell proliferation as well as the activation of Akt/Cyclin D1 signaling.	Acetylcysteine	119-136	cyclin D1	Homo sapiens	218-227
30896878-6	2019	Mechanistically, CsA treatment increased reactive oxygen species (ROS) generation, and the intracellular ROS scavenger N-acetyl-cysteine (NAC) attenuated CsA-induced cell proliferation as well as the activation of Akt/Cyclin D1 signaling.	Acetylcysteine	138-141	cyclin D1	Homo sapiens	218-227
30896878-6	2019	Mechanistically, CsA treatment increased reactive oxygen species (ROS) generation, and the intracellular ROS scavenger N-acetyl-cysteine (NAC) attenuated CsA-induced cell proliferation as well as the activation of Akt/Cyclin D1 signaling.	Cyclosporine	154-157	cyclin D1	Homo sapiens	218-227
30910432-4	2019	Furthermore, we found that arecoline reduces the protein level of cyclin D1, but it has no effect on its mRNA level and protein stability, implying that arecoline may modulate the translation of cyclin D1.	Arecoline	27-36	cyclin D1	Homo sapiens	66-75
30910432-4	2019	Furthermore, we found that arecoline reduces the protein level of cyclin D1, but it has no effect on its mRNA level and protein stability, implying that arecoline may modulate the translation of cyclin D1.	Arecoline	27-36	cyclin D1	Homo sapiens	195-204
30910432-4	2019	Furthermore, we found that arecoline reduces the protein level of cyclin D1, but it has no effect on its mRNA level and protein stability, implying that arecoline may modulate the translation of cyclin D1.	Arecoline	153-162	cyclin D1	Homo sapiens	195-204
30910432-5	2019	We also observed the downregulation of the Akt/mTOR signaling pathway after treatment with arecoline, which may be related to the translation of cyclin D1.	Arecoline	91-100	cyclin D1	Homo sapiens	145-154
30959969-3	2019	Toward SK-Hep-1 and SNU-423 cells, ponatinib induces apoptosis by upregulation of cleaved caspase-3 and -7 and promotes cell cycle arrest in the G1 phase by inhibiting CDK4/6/CyclinD1 complex and phosphorylation of retinoblastoma protein.	ponatinib	35-44	cyclin D1	Homo sapiens	175-183
30962952-6	2019	Copanlisib strongly reduced cell viability and colony formation in different native and sorafenib-resistant HCC cell lines by affecting cyclin D1/CDK4/6 signaling and causing cell cycle arrest.	copanlisib	0-10	cyclin D1	Homo sapiens	136-145
30962952-6	2019	Copanlisib strongly reduced cell viability and colony formation in different native and sorafenib-resistant HCC cell lines by affecting cyclin D1/CDK4/6 signaling and causing cell cycle arrest.	Sorafenib	88-97	cyclin D1	Homo sapiens	136-145
30939155-7	2019	Digoxin modified the effects of statins on ATF3, p21, p53, and cyclin D1 expression, while fluvastatin boosted its DNA damage effect and lovastatin impeded its DNA damage effect.	Digoxin	0-7	cyclin D1	Homo sapiens	63-72
30755485-10	2019	The 5"-iodotubercidin treatment also suppressed beta-catenin, lymphoid enhancer-binding factor 1 (LEF-1), cyclin D1, N-Myc, and INSM1 levels, ultimately leading to apoptosis via caspase-3 and p53 activation.	5-iodotubercidin	4-21	cyclin D1	Homo sapiens	106-115
31217064-0	2019	2,3,7,8-Tetrachlorodibenzo-p-dioxin Promotes Proliferation of Astrocyte Cells via the Akt/STAT3/Cyclin D1 Pathway.	Polychlorinated Dibenzodioxins	0-35	cyclin D1	Homo sapiens	96-105
33911565-9	2019	Results: Treatment with ceramides increased the expression of proteins affecting cell proliferation such as Bcl-2, BAX, phosphorylated-ERK and Cyclin D1.	Ceramides	24-33	cyclin D1	Homo sapiens	143-152
30784907-7	2019	Results Sinomenine significantly suppressed cell proliferation, promoted apoptosis and inhibited migration and invasion, as well as down-regulated Cyclin D1, CDK4, Bcl-2, MMP-2, MMP-9, Vimentin protein levels and up-regulated p16 and Bax protein levels in PC3 cells.	sinomenine	8-18	cyclin D1	Homo sapiens	147-156
31217064-7	2019	The exposure to TCDD resulted in the upregulation in the expression levels of phosphorylated protein kinase B (p-Akt), phosphorylated STAT3, and cyclin D1 in a dose- and time-dependent manner.	Polychlorinated Dibenzodioxins	16-20	cyclin D1	Homo sapiens	145-154
31217064-8	2019	The inhibition of Akt expression with LY294002 or STAT3 expression with AG490 abolished the TCDD-induced cyclin D1 upregulation and cell proliferation.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	72-77	cyclin D1	Homo sapiens	105-114
31217064-8	2019	The inhibition of Akt expression with LY294002 or STAT3 expression with AG490 abolished the TCDD-induced cyclin D1 upregulation and cell proliferation.	Polychlorinated Dibenzodioxins	92-96	cyclin D1	Homo sapiens	105-114
31217064-11	2019	CONCLUSION: TCDD exposure promotes the proliferation of astrocyte cells via the Akt/STAT3/cyclin D1 pathway, leading to astrogliosis.	Polychlorinated Dibenzodioxins	12-16	cyclin D1	Homo sapiens	90-99
30590302-5	2019	BPAF in low concentration significantly enhances the protein expression of estrogen receptor alpha (ERalpha), G protein-coupled receptor (GPER), c-Myc, and Cyclin D1, as well as increases phosphorylation levels of protein kinase B (Akt) and extracellular signal-regulated kinase (Erk) in MCF-7 cells.	4,4'-hexafluorisopropylidene diphenol	0-4	cyclin D1	Homo sapiens	156-165
30474823-8	2019	The cyclin D1-negative group showed higher serum cortisol levels compared to the cyclin D1-positive group (p = 0.01).	Hydrocortisone	49-57	cyclin D1	Homo sapiens	4-13
30720080-7	2019	Western blot analysis revealed that BP-1-102 inhibited the phosphorylation of STAT3 and its target genes, including c-Myc, cyclin D1 and survivin, in a time- and dose-dependent manner.	BP-1-102	36-44	cyclin D1	Homo sapiens	123-132
30720134-10	2019	The inhibitory effects of TCRV on EMT and the induction of apoptosis were exerted through the suppression of the sonic hedgehog (Shh) pathway, and through the modulation of cyclin D1 and Bcl-2 expression.	tcrv	26-30	cyclin D1	Homo sapiens	173-182
30720135-8	2019	Taken together and in light of our previous findings that the aspirin-like analogues can affect cyclin D1 expression and nuclear factor-kappaB localisation, it was hypothesized that aspirin and aspirin analogues significantly and swiftly perturb the EGFR axis and that the protective activity of aspirin may in part be explained by perturbed EGFR internalisation and activation.	Aspirin	62-69	cyclin D1	Homo sapiens	96-105
30720135-8	2019	Taken together and in light of our previous findings that the aspirin-like analogues can affect cyclin D1 expression and nuclear factor-kappaB localisation, it was hypothesized that aspirin and aspirin analogues significantly and swiftly perturb the EGFR axis and that the protective activity of aspirin may in part be explained by perturbed EGFR internalisation and activation.	Aspirin	182-189	cyclin D1	Homo sapiens	96-105
30720135-8	2019	Taken together and in light of our previous findings that the aspirin-like analogues can affect cyclin D1 expression and nuclear factor-kappaB localisation, it was hypothesized that aspirin and aspirin analogues significantly and swiftly perturb the EGFR axis and that the protective activity of aspirin may in part be explained by perturbed EGFR internalisation and activation.	Aspirin	182-189	cyclin D1	Homo sapiens	96-105
30720135-8	2019	Taken together and in light of our previous findings that the aspirin-like analogues can affect cyclin D1 expression and nuclear factor-kappaB localisation, it was hypothesized that aspirin and aspirin analogues significantly and swiftly perturb the EGFR axis and that the protective activity of aspirin may in part be explained by perturbed EGFR internalisation and activation.	Aspirin	182-189	cyclin D1	Homo sapiens	96-105
30822424-9	2019	Meanwhile, down-regulation of Cyclin D1, MMP-2 and Vimentin, up-regulations of p53 and p21, as well as cleavage of caspase-3 and -9 were observed in Salidroside-treated cell.	rhodioloside	149-160	cyclin D1	Homo sapiens	30-39
30311108-6	2019	The addition of ERK inhibitor PD98059 counteracted the upregulation of Snail, Cyclin D1 and Cyclin E1, and restored the expression of E-cadherin, which indicated that C6orf106 was an upstream factor of ERK signaling pathway.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	30-37	cyclin D1	Homo sapiens	78-87
30899002-3	2019	Here we demonstrate that Rb and mTORC1 contribute to Gln-addiction upon the dysregulation of the Fbxo4-cyclin D1 axis, which leads to the reprogramming of cellular metabolism.	Glutamine	53-56	cyclin D1	Homo sapiens	103-112
30826569-9	2019	The antitumor effects of nor-wogonin can be attributed to cell cycle arrest via reduction of the expression of cyclin D1, cyclin B1, and CDK1.	norwogonin	25-36	cyclin D1	Homo sapiens	111-120
30902084-8	2019	TSA reduced PCNA, cyclin D1, cyclin E1, CDK2, p16 and p21 expressions and stimulated CDK6 levels.	trichostatin A	0-3	cyclin D1	Homo sapiens	18-27
30936742-0	2019	Nano-curcumin"s suppression of breast cancer cells (MCF7) through the inhibition of cyclinD1 expression.	Curcumin	5-13	cyclin D1	Homo sapiens	84-92
30890138-7	2019	RESULTS: Swainsonine significantly hindered cell proliferation through decreasing cell viability, declining the percentage of BrdU cells, down-regulating CyclinD1 and up-regulating p16 expression.	Swainsonine	9-20	cyclin D1	Homo sapiens	154-162
30874538-7	2019	We also found that increased expression of p21 and decreased expression of CDK7, Cyclin D1, and Cyclin A2 participating in beta-Thujaplicin caused the S-phase arrest.	beta-thujaplicin	123-139	cyclin D1	Homo sapiens	81-90
30936742-15	2019	In addition, curcumin was able to significantly reduce the expression of cyclinD1, whereas CAF did not alter cyclinD1 expression.	Curcumin	13-21	cyclin D1	Homo sapiens	73-81
30936742-16	2019	Conclusion: Nano-curcumin has a relatively high cytotoxic effect on MCF7 breast cancer cells, suppressing the expression of cyclinD1, a critical gene in the development and metastasis of breast cancer.	Curcumin	17-25	cyclin D1	Homo sapiens	124-132
30509103-5	2019	The results showed that Skullcapflavone I significantly suppressed cell proliferation and viability and down-regulated PCNA and Cyclin D1protein levels.	skullcapflavone	24-39	cyclin D1	Homo sapiens	128-137
31182915-6	2019	Additionally, CyclinD1 accumulation was increased in response to chloroquine (CQ) or in MEF Atg7 knockout cells.	Chloroquine	65-76	cyclin D1	Homo sapiens	14-22
31182915-6	2019	Additionally, CyclinD1 accumulation was increased in response to chloroquine (CQ) or in MEF Atg7 knockout cells.	Chloroquine	78-80	cyclin D1	Homo sapiens	14-22
30616080-9	2019	PGG affected cell cycle- or apoptosis-related proteins such as cyclin D1, Bcl-2 and Bax.	beta-penta-O-galloyl-glucose	0-3	cyclin D1	Homo sapiens	63-72
30553812-4	2019	Exposure to BLT2 siRNA or LY255283, a specific BLT2 inhibitor, clearly suppressed the proliferation of KRAS mutant colorectal cancer cells and markedly increased cell cycle arrest by downregulating the PI3K/Akt-cyclin D1 cascade.	LY 255283	26-34	cyclin D1	Homo sapiens	211-220
30854080-6	2019	In addition, cell cycle distribution analysis revealed that G0/G1 phase arrest was induced following pristimerin treatment in CAL-27 and SCC-25 cells, which was strongly associated with upregulation of p21 and p27, coupled with downregulation of cyclin D1 and cyclin E. Meanwhile, pristimerin induced significant apoptosis of CAL-27 and SCC-25 cells, alongside decreased levels of caspase-3 and specific cleavage of poly (ADP-ribose) polymerase.	pristimerin	101-112	cyclin D1	Homo sapiens	246-255
30569123-8	2019	Specific inhibition of AKT by MK2206 reduced the expression of p-PEA-15 at the Ser116 residue, resulting in sequential downregulation of p-ERK1/2, cyclin D1 and caspase-8 activation.	MK 2206	30-36	cyclin D1	Homo sapiens	147-156
30463098-4	2019	In this study, we explore the influence of cucurbitacin B from Trichosanthes cucumerina on the methylation status at the promoter of oncogenes c-Myc, cyclin D1, and survivin in breast cancer cell lines.	cucurbitacin B	43-57	cyclin D1	Homo sapiens	150-159
30565332-4	2019	Our findings concluded that BCH showed good inhibition on the HCC proliferation and colony formation, which attributed to cell cycle arrest by BCH at G1 phase through impairing the expression of cyclinD1, cyclinE, and cdc2 and downregulated the phosphorylation of Akt, mTOR, and ERK.	bis(cyclohexylammonium)sulfate	28-31	cyclin D1	Homo sapiens	195-203
30819233-7	2019	In gene expression analysis, CCND1-amplified luminal A tumours showed increased proliferation (P &lt; 0.001) and decreased progesterone (P = 0.002) levels along with a large overlap in differentially expressed genes when comparing luminal A and B-amplified vs. non-amplified tumours.	Progesterone	123-135	cyclin D1	Homo sapiens	29-34
30853911-9	2019	Taken together, our data provide a mechanism by which GBM cells can exhibit TMZ-induced resistance through miRNA targeting of Cyclin D1.	Temozolomide	76-79	cyclin D1	Homo sapiens	126-135
30863177-8	2019	Besides, forskolin obviously reduced the expression of beta-catenin protein, promoted its ubiquitination, enhanced its transportation from nuclear to cytoplasm, as well as decreased the expression of its downstream oncogenes c-myc and cyclin D1 through upregulating Axin expression and stability and inhibiting Axin ubiquitination.	Colforsin	9-18	cyclin D1	Homo sapiens	235-244
30949393-4	2019	Flow cytometry analysis revealed that hydrangenol suppressed the VEGF-induced inhibition of G1-cell cycle phase and also decreased cyclin D1, cyclin E, CDK2, and CDK4 levels.	hydrangenol	38-49	cyclin D1	Homo sapiens	131-140
29688163-0	2019	Human amniotic fluid stem cells (hAFSCs) expressing p21 and cyclin D1 genes retain excellent viability after freezing with (dimethyl sulfoxide) DMSO.	Dimethyl Sulfoxide	124-142	cyclin D1	Homo sapiens	60-69
30824767-6	2019	Fenofibrate caused S and G2/M cell cycle arrest by inducing cyclin A/Cdk2 and reducing cyclin D1 and E protein levels in Hep3B cells.	Fenofibrate	0-11	cyclin D1	Homo sapiens	87-110
30853938-4	2019	Here we show that the dynamic and reversible O-linked beta-N-Acetyl-glucosaminylation (O-GlcNAcylation) regulates also cyclin D1 half-life.	Nitrogen	58-60	cyclin D1	Homo sapiens	119-128
30853938-4	2019	Here we show that the dynamic and reversible O-linked beta-N-Acetyl-glucosaminylation (O-GlcNAcylation) regulates also cyclin D1 half-life.	Cysteine	61-67	cyclin D1	Homo sapiens	119-128
29688163-0	2019	Human amniotic fluid stem cells (hAFSCs) expressing p21 and cyclin D1 genes retain excellent viability after freezing with (dimethyl sulfoxide) DMSO.	Dimethyl Sulfoxide	144-148	cyclin D1	Homo sapiens	60-69
30736789-7	2019	Decreased level of cyclin D1 protein was observed in SW480 cells treated with STL or STB, but no change in cyclin D1 mRNA level was observed with the treatment of STL or STB.	stb	85-88	cyclin D1	Homo sapiens	19-28
30736789-8	2019	MG132 blocked downregulation of cyclin D1 protein by STL or STB.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	0-5	cyclin D1	Homo sapiens	32-41
30736802-5	2019	In this study, we aim to determine the usefulness of Cyclin D1 in differentiating between CCSK and other pediatric renal neoplasms and to compare our results with those of recently published studies.	ccsk	90-94	cyclin D1	Homo sapiens	53-62
30736802-10	2019	RESULTS: Most or all cases of CCSK, neuroblastoma and renal Ewing sarcoma demonstrated diffuse and strong positivity for Cyclin D1.	ccsk	30-34	cyclin D1	Homo sapiens	121-130
30736802-13	2019	CONCLUSIONS: Cyclin D1 is a sensitive but not specific immunohistochemical marker for CCSK and many other pediatric renal malignant neoplasms as well as for neuroblastoma.	ccsk	86-90	cyclin D1	Homo sapiens	13-22
30736802-15	2019	However, Cyclin D1 is very helpful in distinguishing between blastema-rich WT and CCSK.	ccsk	82-86	cyclin D1	Homo sapiens	9-18
30585173-5	2019	The acetoxymethyl ester of (S)-2, i.e., 6, suppressed cyclin D1 expression in human prostate cancer PC-3 cells, and exhibited cytotoxicity.	acetoxymethyl ester	4-23	cyclin D1	Homo sapiens	54-63
31119047-14	2019	Reciprocally, CYH33 abrogated the PD0332991-induced up-regulation of cyclin D1 and phosphorylation of AKT in A549 cells.	UNII-RCA38L4HB5	14-19	cyclin D1	Homo sapiens	69-78
31119047-14	2019	Reciprocally, CYH33 abrogated the PD0332991-induced up-regulation of cyclin D1 and phosphorylation of AKT in A549 cells.	palbociclib	34-43	cyclin D1	Homo sapiens	69-78
30453015-8	2019	Enforced expression of miR-382-5p or specific PTEN inhibitors inhibited ATRA-induced granulocytic differentiation via regulation of the cell cycle regulator cyclinD1.	Tretinoin	72-76	cyclin D1	Homo sapiens	157-165
29872938-9	2019	Results Rucaparib suppressed proliferation, induced G2/M phase arrest, and reduced the expression of cyclin D1 and CDK4 in cervical cancer cells.	rucaparib	8-17	cyclin D1	Homo sapiens	101-110
30461193-5	2019	We found that the down-regulation of PRMT5 by shRNA or the inhibition of PRMT5 by specific inhibitor GSK591 dramatically suppressed cyclin E1 and cyclin D1 expression and cell proliferation.	GSK591	101-107	cyclin D1	Homo sapiens	146-155
30535469-8	2019	Inhibition of glycogen synthase kinase 3beta activity by phosphorylation of its N-terminal serine increases accumulation of cyclin D1, which promotes the cell cycle and improves cell proliferation through the PI3K/Akt signaling pathway.	Serine	91-97	cyclin D1	Homo sapiens	124-133
30305722-4	2019	Serine-dephosphorylated form of Leo1 binds directly to beta-catenin, promoting the nuclear accumulation of beta-catenin and transactivation of TCF/LEF downstream target genes such as cyclin D1 and c-myc.	Serine	0-6	cyclin D1	Homo sapiens	183-192
30483745-0	2019	AT-101 induces G1/G0 phase arrest via the beta-catenin/cyclin D1 signaling pathway in human esophageal cancer cells.	gossypol acetic acid	0-6	cyclin D1	Homo sapiens	55-64
30483745-7	2019	XAV-939, a small molecule that inhibits the Wnt/beta-catenin signaling pathway by facilitating beta-catenin degradation, lowered beta-catenin and cyclin D1 protein expression to an extent similar to AT-101.	XAV939	0-3	cyclin D1	Homo sapiens	146-155
30483745-8	2019	XAV-939 alone resulted in G1/G0 phase arrest and further induced cell cycle arrest in combination with AT-101, suggesting that the beta-catenin/cyclin D1 signaling pathway mediated, at least in part, the cell cycle arrest induced by AT-101.	XAV939	0-7	cyclin D1	Homo sapiens	144-153
30483745-8	2019	XAV-939 alone resulted in G1/G0 phase arrest and further induced cell cycle arrest in combination with AT-101, suggesting that the beta-catenin/cyclin D1 signaling pathway mediated, at least in part, the cell cycle arrest induced by AT-101.	Astatine	103-105	cyclin D1	Homo sapiens	144-153
30483745-8	2019	XAV-939 alone resulted in G1/G0 phase arrest and further induced cell cycle arrest in combination with AT-101, suggesting that the beta-catenin/cyclin D1 signaling pathway mediated, at least in part, the cell cycle arrest induced by AT-101.	Astatine	233-235	cyclin D1	Homo sapiens	144-153
30340049-8	2019	In addition, PD98059 (a MEK inhibitor) could block cell differentiation of CML cells and contributed to the expression of c-myc and cyclin D1.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	13-20	cyclin D1	Homo sapiens	132-141
30463098-10	2019	Upon cucurbitacin B treatment, upregulation of DNMT1 and obvious heavy methylation in the promoters of c-Myc, cyclin D1, and survivin, which consequently downregulated the expression of all these oncogenes, were observed.	cucurbitacin B	5-19	cyclin D1	Homo sapiens	110-119
30562828-6	2019	Furthermore, damulin B activated the following: both intrinsic and extrinsic apoptosis pathways along with early G1 phase arrest via the upregulation of the Bax, Bid, tBid, cleaved caspase-8, and p53 expression levels; downregulation of the procaspase-8/-9, CDK4, CDK6, and cyclin D1 expression levels; and more release of cytochrome c in the cytoplasm.	damulin B	13-22	cyclin D1	Homo sapiens	274-283
30669360-0	2019	Tetracenomycin X Exerts Antitumour Activity in Lung Cancer Cells through the Downregulation of Cyclin D1.	5838 DNI	0-14	cyclin D1	Homo sapiens	95-104
30669360-5	2019	Tetracenomycin X exerts antitumour activity through cell cycle arrest induced by the downregulation of cyclin D1.	5838 DNI	0-14	cyclin D1	Homo sapiens	103-112
30669360-6	2019	To explore the specific mechanism, we found that tetracenomycin X directly induced cyclin D1 proteasomal degradation and indirectly downregulated cyclin D1 via the activation of p38 and c-JUN proteins.	tetracenomycin X	49-65	cyclin D1	Homo sapiens	83-92
30669360-6	2019	To explore the specific mechanism, we found that tetracenomycin X directly induced cyclin D1 proteasomal degradation and indirectly downregulated cyclin D1 via the activation of p38 and c-JUN proteins.	tetracenomycin X	49-65	cyclin D1	Homo sapiens	146-155
30705597-5	2019	The gene and protein expression levels of NR1H3, cyclin D1 (CCND1), and cyclin E (CCNE) in cells pretreated with different concentrations of TO901317 for different periods of time were also detected by real-time RT-PCR and Western blot, respectively.	T0901317	141-149	cyclin D1	Homo sapiens	49-58
30705597-5	2019	The gene and protein expression levels of NR1H3, cyclin D1 (CCND1), and cyclin E (CCNE) in cells pretreated with different concentrations of TO901317 for different periods of time were also detected by real-time RT-PCR and Western blot, respectively.	T0901317	141-149	cyclin D1	Homo sapiens	60-65
30705597-9	2019	Furthermore, the administration of TO901317 not only promoted the expression of NR1H3 but also inhibited the expression of CCND1 and CCNE in Ishikawa cells.	T0901317	35-43	cyclin D1	Homo sapiens	123-128
30389635-5	2019	Celastrol resulted in a G2/M cell cycle arrest, accompanied with the down-regulation of Cyclin D1, CDK2, and CDK4.	celastrol	0-9	cyclin D1	Homo sapiens	88-97
30274983-7	2019	ER transcriptional reporter assays, gene expression, and immunoblot analyses showed that treatment with neratinib/fulvestrant, but not fulvestrant, potently inhibited growth and downregulated ER reporter activity, P-AKT, P-ERK, and cyclin D1 levels.	neratinib	104-113	cyclin D1	Homo sapiens	232-241
31364516-15	2019	Cell cycle analysis revealed that carvacrol prevented cell cycle in G0/G1 that was associated with decline in expression of cyclin D1 and Cyclin-Dependent Kinase 4 (CDK4) and augmented expression of CDK inhibitor p21.	carvacrol	34-43	cyclin D1	Homo sapiens	124-133
30655700-13	2019	HCEE promoted cell cycle arrest at G1 phase in HeLa cells by upregulating the levels of p53 and p21 and downregulating the levels of cyclin D1, CDK-4, and CDK-6.	hcee	0-4	cyclin D1	Homo sapiens	133-142
31096773-6	2019	Here, we indicated that amentoflavone not only diminished NF- kappa B activation, but also reduced NF- kappa B-mediated downstream oncogenes expression, such as MMP-2, MMP-9, XIAP, cyclinD1 and VEGF, which was elucidated by Western blot and immunohistochemistry (IHC).	amentoflavone	24-37	cyclin D1	Homo sapiens	181-189
30198914-4	2019	9-Cis-RA also induced G0/G1 cell cycle arrest by downregulation of cyclin D1.	Alitretinoin	0-8	cyclin D1	Homo sapiens	67-76
30874462-5	2019	Mechanistically, RPL22/eL22 can interact with and inhibit CDK4-Cyclin D1 to decrease RB phosphorylation both in vitro and in cells.	Rubidium	85-87	cyclin D1	Homo sapiens	63-72
30909183-12	2019	CONCLUSION: The results of this study demonstrate that ginsenoside inhibits proliferation and promotes apoptosis of human OS MG-63 and Saos-2 cells by reducing the expressions of beta-catenin, Bcl-2 and Cyclin D1 and increasing the expression of Bax and cleaved caspase-3.	Ginsenosides	55-66	cyclin D1	Homo sapiens	203-212
30307360-6	2019	Molecularly, SAHA-treated cells showed activation of a DNA damage response, induction of the cell cycle inhibitors p21Cip1 and p27Kip1 and downregulation of Cyclin D1.	Vorinostat	13-17	cyclin D1	Homo sapiens	157-166
30467747-4	2019	In the current study, low concentrations of BPA reduced TAM-induced cytotoxicity of MCF-7 cells, which was proved by the suppression of cell apoptosis, transition of cell cycle from G1 to S phase, and upregulation of cyclin D1 and ERalpha.	bisphenol A	44-47	cyclin D1	Homo sapiens	217-226
30084835-9	2019	Mechanistically, palbociclib was found to potentiate MLN0128 mTOR inhibition activity, whereas MLN0128 prevented the upregulation of cyclin D1 induced by palbociclib treatment.	INK128	95-102	cyclin D1	Homo sapiens	133-142
30084835-9	2019	Mechanistically, palbociclib was found to potentiate MLN0128 mTOR inhibition activity, whereas MLN0128 prevented the upregulation of cyclin D1 induced by palbociclib treatment.	palbociclib	154-165	cyclin D1	Homo sapiens	133-142
30245290-18	2019	Upregulation of miR-139-5p inhibited the expression of Cyclin D1 and VEGFR-1 and increased the expression of E-cadherin.	mir-139-5p	16-26	cyclin D1	Homo sapiens	55-64
30467747-4	2019	In the current study, low concentrations of BPA reduced TAM-induced cytotoxicity of MCF-7 cells, which was proved by the suppression of cell apoptosis, transition of cell cycle from G1 to S phase, and upregulation of cyclin D1 and ERalpha.	Tamoxifen	56-59	cyclin D1	Homo sapiens	217-226
30472705-8	2019	Cyclin D1, estrogen receptor 1, catechol-O-methyltransferase, and cathepsin D (CTSD; hub genes) were the predicted new genes associated with beta-estradiol.	Estradiol	141-155	cyclin D1	Homo sapiens	0-30
30387805-7	2019	Additionally, resveratrol treatment decreased the protein expression levels of cyclin D1, cyclin E2 and BCL2 apoptosis regulator, while it increased BCL2 associated X and tumor protein p53, all of which are involved in the regulation of cell cycle and apoptosis.	Resveratrol	14-25	cyclin D1	Homo sapiens	79-88
30431107-8	2019	The restoration of CCND1 expression significantly abolished the inhibitory effects of miR-584 overexpression on pancreatic cancer cells.	mir-584	86-93	cyclin D1	Homo sapiens	19-24
30359864-0	2019	Quercetin inhibits proliferation of endometriosis regulating cyclin D1 and its target microRNAs in vitro and in vivo.	Quercetin	0-9	cyclin D1	Homo sapiens	61-70
30431107-9	2019	Collectively, the present results demonstrated that miR-584 inhibited the development of pancreatic cancer by directly targeting CCND1, suggesting that this miRNA may represent a potential therapeutic target for this fatal disease.	mir-584	52-59	cyclin D1	Homo sapiens	129-134
30104711-11	2019	ISA-2011B-treatment reduced expression of pSer-473 AKT (p &lt; 0.001) and its downstream effectors including cyclin D1, VEGF and its receptors, VEGFR1 and VEGFR2 (p &lt; 0.001) in xenograft tumors.	ISA-2011B	0-9	cyclin D1	Homo sapiens	109-118
30661406-3	2019	MTT assay results showed a reduction of HeLa cells viability OLE-induced, concomitantly with a gene and protein down-regulation of Cyclin-D1 and an up-regulation of p21, triggering intrinsic apoptosis.	monooxyethylene trimethylolpropane tristearate	0-3	cyclin D1	Homo sapiens	131-140
30663403-0	2019	Isochamanetin is a Selective Inhibitor for CyclinD1 in SKOV3 Cell Lines.	Isochamanetin	0-13	cyclin D1	Homo sapiens	43-51
30663403-4	2019	In the present study we identified that the expression levels of Bcl-2, Bax, caspase 8, 9 and cyclinD1 using Q-PCR method in SKOV3 cell lines treated with Isochamanetin.	Isochamanetin	155-168	cyclin D1	Homo sapiens	94-102
30663403-6	2019	Further the expression levels of Bcl-2, caspase8,9, Cytochrome C and CyclinD1 were significantly down regulated in SKOV3 cancer cells treated with isochamanetin, a specific binding molecule to CyclinD1.	Isochamanetin	147-160	cyclin D1	Homo sapiens	69-77
30663403-6	2019	Further the expression levels of Bcl-2, caspase8,9, Cytochrome C and CyclinD1 were significantly down regulated in SKOV3 cancer cells treated with isochamanetin, a specific binding molecule to CyclinD1.	Isochamanetin	147-160	cyclin D1	Homo sapiens	193-201
30663403-9	2019	The current result suggests that isochamanetin serves as potent binding agent to the cyclinD1.	Isochamanetin	33-46	cyclin D1	Homo sapiens	85-93
29495973-7	2018	The overexpressed CCND1 in GC tissues was negatively correlated with miR-623 level.	mir-623	69-76	cyclin D1	Homo sapiens	18-23
30448832-4	2019	Effects of propranolol on apoptosis and expressions of cell cycle-related genes, CDK4 and cyclin D1, were detected by flow cytometry and RT-PCR respectively.	Propranolol	11-22	cyclin D1	Homo sapiens	90-99
30448832-6	2019	RESULTS: Propranolol significantly inhibited the CoCl2-induced hypoxic proliferation of HUVECs in a dose-dependent manner, and also induced apoptosis and suppressed the expression of CDK4 and cyclin D1.	Propranolol	9-20	cyclin D1	Homo sapiens	192-201
30448832-6	2019	RESULTS: Propranolol significantly inhibited the CoCl2-induced hypoxic proliferation of HUVECs in a dose-dependent manner, and also induced apoptosis and suppressed the expression of CDK4 and cyclin D1.	cobaltous chloride	49-54	cyclin D1	Homo sapiens	192-201
29495973-0	2018	MicroRNA-623 Targets Cyclin D1 to Inhibit Cell Proliferation and Enhance the Chemosensitivity of Cells to 5-Fluorouracil in Gastric Cancer.	Fluorouracil	106-120	cyclin D1	Homo sapiens	21-30
30580326-5	2018	The effects of naringin, which included downregulation of Cyclin D1, MMP2, and bcl-2, where reproduced by siRNA-mediated Zeb1 silencing, whereas Zeb1 overexpression increased proliferation, migration, and Cyclin D1, MMP2, and bcl-2 levels.	naringin	15-23	cyclin D1	Homo sapiens	58-67
30580326-5	2018	The effects of naringin, which included downregulation of Cyclin D1, MMP2, and bcl-2, where reproduced by siRNA-mediated Zeb1 silencing, whereas Zeb1 overexpression increased proliferation, migration, and Cyclin D1, MMP2, and bcl-2 levels.	naringin	15-23	cyclin D1	Homo sapiens	205-214
30292139-5	2018	Mechanism dissection suggests that the combination of MLN8237 and sorafenib led to significant inhibition of the activation of phospho-Akt (p-Akt) and phospho-p38 mitogen-activated protein kinase (p-p38 MAPK) and their downstream genes including CDK4, cyclinD1, and VEGFA.	MLN 8237	54-61	cyclin D1	Homo sapiens	252-260
30292139-5	2018	Mechanism dissection suggests that the combination of MLN8237 and sorafenib led to significant inhibition of the activation of phospho-Akt (p-Akt) and phospho-p38 mitogen-activated protein kinase (p-p38 MAPK) and their downstream genes including CDK4, cyclinD1, and VEGFA.	Sorafenib	66-75	cyclin D1	Homo sapiens	252-260
30253373-6	2018	RESULTS: Cell viability, proliferation and cyclinD1 expression level in A549 cells were all reduced by kaempferol.	kaempferol	103-113	cyclin D1	Homo sapiens	43-51
30247801-4	2018	Mechanism analysis found that tigecycline led to cell cycle arrest at G0/G1 with down-regulation of p21, CDK2 and cyclin D1, rather than induced apoptosis, in MM cells.	Tigecycline	30-41	cyclin D1	Homo sapiens	114-123
30187481-7	2018	Furthermore, EGCG could inhibit breast cancer cell proliferation and promote apoptosis by modulating CCND1.	epigallocatechin gallate	13-17	cyclin D1	Homo sapiens	101-106
30717563-7	2018	The results of Western blot showed that orchinol could significantly down-regulate the protein expression levels of beta-catenin, Wnt3a, DvL2 and cyclinD1, and up-regulate the protein expression level of GSK-3beta(P&lt;0.05, P&lt;0.01, P&lt;0.001).	orchinol	40-48	cyclin D1	Homo sapiens	146-154
30542720-6	2019	Moreover, as shown using western blot analysis, the levels of p-AKT, p-GSK-3beta, Bcl-2, and cyclin D1 were decreased after AZD6482 treatment.	2-(1-(7-methyl-2-morpholin-4-yl-4-oxo-4H-pyrido(1,2-a)pyrimidin-9-yl)ethylamino)benzoic acid	124-131	cyclin D1	Homo sapiens	93-102
30599890-10	2019	Further investigation of the mechanism of action of curcumin and quercetin in melanoma cells, A375, suggested that inhibition of cell proliferation occurred through down-regulation of Wnt/beta-catenin signaling pathway proteins, DVL2, beta-catenin, cyclin D1, Cox2, and Axin2.	Curcumin	52-60	cyclin D1	Homo sapiens	249-258
30201337-7	2018	Additionally, hyperoside and let-7a-5p had a synergetic effect on suppressing the proliferation of A549 cells; microRNA-let-7a-5p directly regulated the expression of CCND1 in A549 cells.	hyperoside	14-24	cyclin D1	Homo sapiens	167-172
30201337-7	2018	Additionally, hyperoside and let-7a-5p had a synergetic effect on suppressing the proliferation of A549 cells; microRNA-let-7a-5p directly regulated the expression of CCND1 in A549 cells.	let-7a-5p	29-38	cyclin D1	Homo sapiens	167-172
30622945-9	2018	Accordingly, PL induced in quiescent cells activation of the proliferation-related pathways ERK, Akt, and STAT-3 and expression of Cyclin D1.	pl	13-15	cyclin D1	Homo sapiens	131-140
29073835-10	2018	Down-regulation of CDK6 and Cyclin D1 in Tca8113 transfected with miR-9 mimics indicate that the complex formed by both proteins may be the effector of the antiproliferative function of miR-9 in OSCCs.	tca8113	41-48	cyclin D1	Homo sapiens	28-37
30553472-9	2018	Besides, the results of GSEA analysis showed that the CCND1 was mostly enriched in lung cancer group.	gsea	24-28	cyclin D1	Homo sapiens	54-59
30484863-8	2018	Taken together, we propose that LBH589 inhibits ESCC cell proliferation mainly through inducing cell cycle arrest by increasing p21 and decreasing cyclin D1 in a p53-independent manner.	Panobinostat	32-38	cyclin D1	Homo sapiens	147-156
29920623-0	2018	Synergistic Anti-proliferative Effects of Metformin and Silibinin Combination on T47D Breast Cancer Cells via hTERT and Cyclin D1 Inhibition.	Metformin	42-51	cyclin D1	Homo sapiens	120-129
29920623-0	2018	Synergistic Anti-proliferative Effects of Metformin and Silibinin Combination on T47D Breast Cancer Cells via hTERT and Cyclin D1 Inhibition.	Silybin	56-65	cyclin D1	Homo sapiens	120-129
30132953-12	2018	Further, combination of INPP4B overexpression and rucaparib declined Myc, cyclin E1 and cyclin D1 expressions, enhanced Bad, Bax, and cleaved-caspase-3 expressions, and blocked PI3K/AKT signal pathway in SaOS2 and U2OS cells.	rucaparib	50-59	cyclin D1	Homo sapiens	88-97
30546426-11	2018	Markedly decreased Akt phosphorylation and cyclin D1 levels and increased p53 levels were detected when cells were transfected with miR-128 mimics.	mir-128	132-139	cyclin D1	Homo sapiens	43-52
29495973-8	2018	The recovered CCND1 expression counteracted the effects of miR-623 on GC cell proliferation, chemosensitivity, and 5-FU-induced apoptosis.	Fluorouracil	115-119	cyclin D1	Homo sapiens	14-19
30316911-5	2018	The results showed that L-NBP elevated the proliferation of NSCs by upregulating cyclin D1, and PI3K/Akt might be a possible target in this process.	l-nbp	24-29	cyclin D1	Homo sapiens	81-90
30020469-11	2018	Conclusion: Two variants of the dominant-negative GRbeta, in conjunction with a common Bcl1 intron variant, resulted in hypersensitivity to endogenous and exogenous glucocorticoids and, as a reflection of severity, low circulating cortisol levels without clinical evidence of glucocorticoid insufficiency.	Hydrocortisone	231-239	cyclin D1	Homo sapiens	87-91
30413753-6	2018	tHGA caused arrest of hBSMC proliferation at the G1 phase of the cell cycle with downregulation of cell cycle proteins, cyclin D1 and diminished degradation of cyclin-dependent kinase inhibitor (CKI), p27Kip1.	2,4,6-trihydroxy-3-geranylacetophenone	0-4	cyclin D1	Homo sapiens	120-129
30226534-10	2018	Sulforaphane inhibited multiple cancer-associated signaling pathways, including B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein, cytochrome c, Caspase-3, phosphorylated AKT, phosphorylated nuclear factor-kappaB, P53, P27, Cyclin-D1 and cMyc, and reduced the expression levels of human epidermal growth factor receptor 2 in human ovarian cancer cells.	sulforaphane	0-12	cyclin D1	Homo sapiens	228-237
30203400-9	2018	Furthermore, Runx2 knockdown suppressed both Ccnd1 mRNA expression and activation of the Ccnd1 promoter by forskolin, a PKA-activating reagent, in C6 glioma cells.	Colforsin	107-116	cyclin D1	Homo sapiens	89-94
30498362-11	2018	Western blotting results revealed that FAM129B upregulated the expression of MMP2 and Cyclin D1 by enhancing the phosphorylation of FAK at Tyr 397 and Tyr 925.	Tyrosine	139-142	cyclin D1	Homo sapiens	86-95
31011108-13	2018	Pioglitazone reduced molecular-PAK biomarkers of proliferation (Ki67 and CyclinD1), and metformin had the opposite effect.	Pioglitazone	0-12	cyclin D1	Homo sapiens	73-81
30326563-6	2018	PTX+BGJ398 induced cell cycle arrest and apoptosis in UC cells with mesenchymal characteristics was accompanied by downregulation of cyclin D1 protein and upregulation of gamma-histone 2A family member X and cleaved poly(ADP-ribose) polymerase.	Paclitaxel	0-3	cyclin D1	Homo sapiens	133-142
30326563-6	2018	PTX+BGJ398 induced cell cycle arrest and apoptosis in UC cells with mesenchymal characteristics was accompanied by downregulation of cyclin D1 protein and upregulation of gamma-histone 2A family member X and cleaved poly(ADP-ribose) polymerase.	infigratinib	4-10	cyclin D1	Homo sapiens	133-142
30402135-16	2018	LY294002 and BSYX evidently downregulated the proteins levels of FSHR, p-Akt/Akt, Gankyrin, and cyclinD1 and upregulated the expression of HIF-alpha protein, and FSH was on the opposite.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	cyclin D1	Homo sapiens	96-104
30302278-6	2018	Consistent with this, YL064 inhibited the nuclear translocation of STAT3 and the expression of STAT3 target genes, such as cyclin D1 and Mcl-1.	yl064	22-27	cyclin D1	Homo sapiens	123-132
30279365-7	2018	The results of the Western blot showed that C8-ceramide causes a dramatically increased protein level of cyclin D1, a critical regulator of cell cycle G1/S transition.	2,3-N-octanoylsphingosine	44-55	cyclin D1	Homo sapiens	105-114
29999407-4	2018	Pretreatment of cells with S1PR2 antagonist JTE013, S1PR3 antagonist CAY10444, or ROCK inhibitor Y27632 blocked S1P-induced alterations of YAP, FOXM1, cyclin D1, and ASMC proliferation, migration, and contraction.	Y 27632	97-103	cyclin D1	Homo sapiens	151-160
30047791-4	2018	METHODS: In the present study, we hypothesized that pioglitazone would decrease proliferation of human leukoplakia cells (MSK Leuk1) and transformed bronchial epithelial cells (BEAS-2B) through regulatory changes of G1 checkpoint protein regulators, p21 and cyclin-D1.	Pioglitazone	52-64	cyclin D1	Homo sapiens	258-267
30007266-5	2018	CBD-induced apoptosis was accompanied by down-regulation of mTOR, cyclin D1 and up-regulation and localization of PPARgamma protein expression in the nuclei and cytoplasmic of the tested cells.	Cannabidiol	0-3	cyclin D1	Homo sapiens	66-75
30003927-6	2018	Nx potentiated growth inhibitory effects of IR by down regulating ribosomal protein S6K (RPS6KB1), CyclinD1, Chk1 and HIF-1 alpha and prolonging G2/M checkpoint block.	nx	0-2	cyclin D1	Homo sapiens	99-107
29744857-4	2018	Accordingly, 10 microM NaHS significantly increased the percentage of cells undergoing DNA replication, elevated the mRNA and/or protein expression of Cyclin A2, Cyclin D1/3, Cyclin E2 and PCNA, and decreased p21 mRNA expression.	sodium bisulfide	23-27	cyclin D1	Homo sapiens	162-173
30117680-7	2018	These results demonstrate for the first time that bradykinin-mediated increase in free Cai2+ via ER-IP3R3 Ca2+ release followed by Ca2+ influx through SOCE channel plays a crucial role in regulating cell growth and migration via activating pAkt, pERK1/2 and cyclin D1 in human cardiac c-Kit+ progenitor cells.	cai2+	87-92	cyclin D1	Homo sapiens	258-267
30265530-6	2018	Moreover, cyadox (2 muM) activated the Akt and increased the EGF, cyclin D1, and FOXO1 expression levels.	cyadox	10-16	cyclin D1	Homo sapiens	66-75
30334455-6	2018	TSA treatment leads to decreased expression of CYCLIN D1, CDK4, CDK6 and BCL-XL, but increased P21 expression.	trichostatin A	0-3	cyclin D1	Homo sapiens	47-56
30555320-3	2018	Para-toluenesulfonamide (PTS) is a small molecule that inhibited cell proliferation of PC-3 and DU-145, two CRPC cell lines, through p21- and p27-independent G1 arrest of cell cycle in which cyclin D1 was down-regulated and Rb phosphorylation was inhibited.	4-toluenesulfonamide	0-23	cyclin D1	Homo sapiens	191-200
30555320-3	2018	Para-toluenesulfonamide (PTS) is a small molecule that inhibited cell proliferation of PC-3 and DU-145, two CRPC cell lines, through p21- and p27-independent G1 arrest of cell cycle in which cyclin D1 was down-regulated and Rb phosphorylation was inhibited.	4-toluenesulfonamide	25-28	cyclin D1	Homo sapiens	191-200
30400136-6	2018	Since the activation of STAT3 and NF-kappaB mediates the expression of survival genes cyclin D1 and survivin, DHA induced apoptosis by suppressing the STAT3/NF-kappaB-cyclin D1/survivin axis.	Docosahexaenoic Acids	110-113	cyclin D1	Homo sapiens	86-95
30400136-6	2018	Since the activation of STAT3 and NF-kappaB mediates the expression of survival genes cyclin D1 and survivin, DHA induced apoptosis by suppressing the STAT3/NF-kappaB-cyclin D1/survivin axis.	Docosahexaenoic Acids	110-113	cyclin D1	Homo sapiens	167-176
30205135-7	2018	In addition, kahweol lowered the levels of phosphorylated Akt and its downstream targets mammalian target of rapamycin (mTOR) and cyclin D1.	kahweol	13-20	cyclin D1	Homo sapiens	130-139
30074282-6	2018	Accordingly, acetylcholine triggers the expression of critical NF-kappaB target genes, such as Cyclin D1 and PCNA, as well as the proliferation of HCC cells in a PP1gamma- and alpha7nAChR-dependent manner.	Acetylcholine	13-26	cyclin D1	Homo sapiens	95-104
30374056-0	2018	Dehydroabietic oximes halt pancreatic cancer cell growth in the G1 phase through induction of p27 and downregulation of cyclin D1.	Oximes	15-21	cyclin D1	Homo sapiens	120-129
30498362-11	2018	Western blotting results revealed that FAM129B upregulated the expression of MMP2 and Cyclin D1 by enhancing the phosphorylation of FAK at Tyr 397 and Tyr 925.	Tyrosine	151-154	cyclin D1	Homo sapiens	86-95
30042033-11	2018	Besides, liraglutide induced an increase of beta-catenin, c-myc, and cyclin D1 levels, which could also be blocked in the presence of Xav939.	XAV939	134-140	cyclin D1	Homo sapiens	69-78
30214619-9	2018	Mechanistically, RME and UA inhibited G1-S phase transition resulting in an increased G1:S+G2/M ratio and decreased cyclin D1 expression.	3-Pyridinecarboxamide, N-ethyl-2-(4-methyl-1-piperazinyl)-	17-20	cyclin D1	Homo sapiens	116-125
30214619-9	2018	Mechanistically, RME and UA inhibited G1-S phase transition resulting in an increased G1:S+G2/M ratio and decreased cyclin D1 expression.	ursolic acid	25-27	cyclin D1	Homo sapiens	116-125
30513211-14	2018	Further studies revealed that EGCG induced cell cycle arrest at G1 by downregulation of cyclin E and cyclin D1 and upregulation of p21.	epigallocatechin gallate	30-34	cyclin D1	Homo sapiens	101-110
30235818-0	2018	Zingerone Suppresses Tumor Development through Decreasing Cyclin D1 Expression and Inducing Mitotic Arrest.	zingerone	0-9	cyclin D1	Homo sapiens	58-67
29864457-5	2018	In this study, we showed that BBP induced proliferation of both ER(+) MCF-7 and ER(-) MDA-MB-231 breast cancer cells, proved by increased cell viability, transition of cell cycle from G1 to S phase, upregulation of proliferating cell nuclear antigen (PCNA) and Cyclin D1, and downregulation of p21.	butylbenzyl phthalate	30-33	cyclin D1	Homo sapiens	261-270
30235818-11	2018	Regarding specific molecular mechanisms, zingerone decreased cyclin D1 expression and induced the cleavage of caspase-3 and poly (ADP-ribose) polymerase 1 (PARP-1).	zingerone	41-50	cyclin D1	Homo sapiens	61-70
30235818-12	2018	The decrease in cyclin D1 and increase in histone H3 phosphorylated (p)-Ser10 were confirmed by immunohistochemistry in tumor tissues administered with zingerone.	zingerone	152-161	cyclin D1	Homo sapiens	16-25
30107167-10	2018	Expression of beta-catenin and Wnt target genes c-Myc, cyclin D1, Axin 2 and survivin was reduced by pimozide treatment in both HCT 116 and SW480 cells.	Pimozide	101-109	cyclin D1	Homo sapiens	55-64
30180865-0	2018	Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA.	Bortezomib	46-56	cyclin D1	Homo sapiens	0-9
30195874-15	2018	Allicin, ATRA, and allicin/ATRA increased the expression of cyclin D1 mRNA in both CD44+ and CD117+ cells.	allicin	0-7	cyclin D1	Homo sapiens	60-69
30195874-15	2018	Allicin, ATRA, and allicin/ATRA increased the expression of cyclin D1 mRNA in both CD44+ and CD117+ cells.	Tretinoin	9-13	cyclin D1	Homo sapiens	60-69
30195874-15	2018	Allicin, ATRA, and allicin/ATRA increased the expression of cyclin D1 mRNA in both CD44+ and CD117+ cells.	allicin	19-26	cyclin D1	Homo sapiens	60-69
30195874-15	2018	Allicin, ATRA, and allicin/ATRA increased the expression of cyclin D1 mRNA in both CD44+ and CD117+ cells.	Tretinoin	27-31	cyclin D1	Homo sapiens	60-69
30201862-4	2018	Furthermore, Moracin D increased sub G1 population; cleaved poly (Adenosine diphosphate (ADP-ribose)) polymerase (PARP); activated cysteine aspartyl-specific protease 3 (caspase 3); and attenuated the expression of c-Myc, cyclin D1, B-cell lymphoma 2 (Bcl-2), and X-linked inhibitor of apoptosis protein (XIAP) in MDA-MB231 cells.	Moracin D	13-22	cyclin D1	Homo sapiens	222-250
29851220-7	2018	Knockdown of CCAT1 by siRNA inhibited Dex-mediated protection against OGD/R-induced injury and promoted cell apoptosis, caspase-3 expression and cell cycle arrest in the G0/G1 phase, and inhibited cell proliferation and cyclin D1 expression.	Dexmedetomidine	38-41	cyclin D1	Homo sapiens	220-229
30091530-5	2018	SAHA and MG132 treatment increased the expression levels of ING5, PTEN, p53, Caspase-3, Bax, p21, and p27 but decreased the expression levels of 14-3-3, MMP-2, MMP-9, ADFP, Nanog, c-myc, CyclinD1, CyclinB1, and Cdc25c concentration dependently, similar to ING5.	Vorinostat	0-4	cyclin D1	Homo sapiens	187-195
30091530-5	2018	SAHA and MG132 treatment increased the expression levels of ING5, PTEN, p53, Caspase-3, Bax, p21, and p27 but decreased the expression levels of 14-3-3, MMP-2, MMP-9, ADFP, Nanog, c-myc, CyclinD1, CyclinB1, and Cdc25c concentration dependently, similar to ING5.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	9-14	cyclin D1	Homo sapiens	187-195
29796912-8	2018	The expression of PCNA, beta-catenin, c-myc, and Cyclin D1 in AOM + DSS/Tg group was significantly higher than that in AOM + DSS/WT group.	Dextran Sulfate	68-71	cyclin D1	Homo sapiens	49-58
30229829-8	2018	Further study on the underlying mechanism found that after overexpression of miR-791, the expressions of Cyclin D1, CKD6 and CDK4 decreased significantly, while the expression of cyclin inhibitor P21 increased significantly.	mir-791	77-84	cyclin D1	Homo sapiens	105-114
30127928-5	2018	Furthermore, treatment with resibufogenin effectively increased Bax/Bcl-2 expression, and suppressed cyclin D1, cyclin E, PI3K, phosphorylated AKT, phosphorylated GSK3beta and beta-catenin protein expression in MGC-803 cells.	bufogenin	28-41	cyclin D1	Homo sapiens	101-110
30135075-6	2018	Finally, we found that expression of cyclin D1 or an oncogenic cyclin D3 mutant or RB1 loss protected NMC cells from BETi-induced cell cycle arrest.	beti	117-121	cyclin D1	Homo sapiens	37-46
30043217-10	2018	Moreover, cantharidin reduced cell proliferation and induced apoptosis with downregulation of STAT3 target genes, such as Bcl-2, COX-2, and cyclin D1.	Cantharidin	10-21	cyclin D1	Homo sapiens	140-149
29654697-3	2018	Furthermore, melatonin reduced the expression of CDK2, CDK4, cyclin D1, cyclin E, and c-Myc and upregulated cyclin B1 in X02 cells.	Melatonin	13-22	cyclin D1	Homo sapiens	61-70
30127932-10	2018	Western blot analysis indicated that oridonin markedly decreased the expression of beta-catenin, cyclin D1 and v-myc avian myelocytomatosis viral oncogene homolog.	oridonin	37-45	cyclin D1	Homo sapiens	97-106
30214285-5	2018	Results: TSA exerted a time and dose-dependent cytotoxicity on MM cell lines, and suppressed the proliferation of MM cells and induced an upregulation of p21 protein accompanied by a decreased expression of cyclin D1.	trichostatin A	9-12	cyclin D1	Homo sapiens	207-216
30146633-10	2018	XPD diminished the phosphorylation of GSK3beta, and SB216763 inhibited the reduction effect of XPD on CDK4 and cyclin D1.	SB 216763	52-60	cyclin D1	Homo sapiens	111-120
30143678-3	2018	We also showed that niclosamide effectively inhibits activation of the Wnt/beta-catenin signaling pathway by targeting multiple components of this pathway, including downregulating the expression beta-catenin, Dishevelled 2 (DVL2), phosphorylated glycogen synthase kinase-3beta (p-GSK3beta) and Cyclin D1, in human OSCC SCC4 and SCC25 cell lines, as well as reduced the formation of primary and secondary tumorspheres.	Niclosamide	20-31	cyclin D1	Homo sapiens	295-304
30175155-7	2018	Also, etomoxir and radiation combination treatment reduced the protein level of biomarkers for proliferation (Ki-67 and cyclin D1), stemness (CD44) and beta-oxidation (CPT1A) in H460 spheres.	etomoxir	6-14	cyclin D1	Homo sapiens	120-129
30066004-5	2018	Chronic arsenite exposure also led to an upregulation of proliferation factors such as cyclin D1, COX2, PCNA, VEGF, and HIF-1alpha.	arsenite	8-16	cyclin D1	Homo sapiens	87-96
30090655-8	2018	Consistently, high glucose decreased cyclin D1 and D3 expression.	Glucose	19-26	cyclin D1	Homo sapiens	37-46
29852353-8	2018	Besides, H2 down-regulated the expression of NIBPL, SMC3, SMC5 and SMC6, and also reduced the expression of Cyclin D1, CDK4 and CDK6.	Hydrogen	9-11	cyclin D1	Homo sapiens	108-117
29956761-9	2018	The phosphorylation of protein kinase B and mechanistic target of rapamycin were significantly inhibited in MKN-28 cells treated with aclidinium bromide; and the activity of the downstream proteins such as p70S6K and Cyclin D1 were also significantly decreased.	aclidinium bromide	134-152	cyclin D1	Homo sapiens	217-226
29767250-2	2018	In this study, using western blot analysis for protein expression and flow cytometry for cell cycle analysis, we determined that the treatment of the LNCaP and PC-3 prostate cancer cells with diosmetin resulted in a marked decrease in cyclin D1, Cdk2 and Cdk4 expression levels (these proteins remain active in the G0-G1 phases of the cell cycle).	diosmetin	192-201	cyclin D1	Homo sapiens	235-244
29989650-9	2018	Furthermore, SAL decreased the expression of beta-catenin and its targets cyclin D1 and C-myc.	salinomycin	13-16	cyclin D1	Homo sapiens	74-83
29709426-7	2018	While knock-outing STIM1 by CRISPR-CAS9 in 16HBE or inhibiting STIM1 mediated SOCE activation ameliorated cell death caused by acute PQ treatment, which also leaded to alleviating the cell accumulation in S phase through the modulation the expression of cyclinD1, p21, cyclinA2 and CDK2.	Paraquat	133-135	cyclin D1	Homo sapiens	254-262
30008879-5	2018	Overexpression of miR-137 suppressed the protein expression of AKT2, increased caspase-3 activity, increased Bax protein expression and suppressed Cyclin D1 protein expression in A549 and H520 cells treated with cisplatin.	Cisplatin	212-221	cyclin D1	Homo sapiens	147-156
30008879-7	2018	The inhibition of AKT2 also increased caspase-3 activity and Bax protein expression, and suppressed Cyclin D1 protein expression in A549 and H520 cells treated with cisplatin following overexpression of miR-137.	Cisplatin	165-174	cyclin D1	Homo sapiens	100-109
30032159-12	2018	Use of BAY 11-7082, a noted NF-kappaB inhibitor, partially abolished overexpression of MMP9 and cyclin D1 by Rab11.	3-(4-methylphenylsulfonyl)-2-propenenitrile	7-18	cyclin D1	Homo sapiens	96-105
30187878-9	2018	10-gingerol at 1, 3, and 10 mumol/L significantly decreased the mRNA expressions of cyclin D1 and CMCC as shown by qPCR (P &lt; 0.01).	gingerol	0-11	cyclin D1	Homo sapiens	84-93
30108651-8	2018	Conclusion: Bufadienolides inhibit proliferation partially due to arresting cell cycle in G1 phase, which is mediated by inhibiting mTOR-cyclin D1/Rb signal pathway.	Bufanolides	12-26	cyclin D1	Homo sapiens	137-146
30008817-12	2018	Semi-quantitative PCR and western blot analysis revealed that the expression levels of p-GSK3beta, beta-catenin, c-Myc and cyclin D1 in cells after ICA treatment were significantly downregulated (p&lt;0.01), while the expression level of caspase-3 was significantly increased (p&lt;0.01).	icariin	148-151	cyclin D1	Homo sapiens	123-132
29710665-5	2018	Voxtalisib arrested cell cycle progression at G1 phase in all cell lines by upregulating p27, downregulating cyclin D1 and p-pRb.	XL765	0-10	cyclin D1	Homo sapiens	109-118
30008840-5	2018	Reverse transcription-polymerase chain reaction and western blot analysis showed that resveratrol downregulated the expression of three important components of the Wnt signaling pathway, beta-catenin, c-myc, and cyclin D1, at the mRNA and protein levels.	Resveratrol	86-97	cyclin D1	Homo sapiens	212-221
29969496-6	2018	CCND1 mutations in endometrial endometrioid adenocarcinoma occurred most commonly in the c-terminus of cyclin D1, as putative driver mutations, in a region thought to result in oncogenic activation of cyclin D1 via inhibition of Thr-286 phosphorylation and nuclear export, thereby resulting in nuclear retention and protein overexpression.	Threonine	229-232	cyclin D1	Homo sapiens	0-5
29969496-6	2018	CCND1 mutations in endometrial endometrioid adenocarcinoma occurred most commonly in the c-terminus of cyclin D1, as putative driver mutations, in a region thought to result in oncogenic activation of cyclin D1 via inhibition of Thr-286 phosphorylation and nuclear export, thereby resulting in nuclear retention and protein overexpression.	Threonine	229-232	cyclin D1	Homo sapiens	103-112
29969496-6	2018	CCND1 mutations in endometrial endometrioid adenocarcinoma occurred most commonly in the c-terminus of cyclin D1, as putative driver mutations, in a region thought to result in oncogenic activation of cyclin D1 via inhibition of Thr-286 phosphorylation and nuclear export, thereby resulting in nuclear retention and protein overexpression.	Threonine	229-232	cyclin D1	Homo sapiens	201-210
29600521-13	2018	Also suppression of AMPK abrogated inhibitory effect of phytosomal-curcumin on thrombin-induced cyclin D1 over-expression, suggesting that AMPK is essential for anti-proliferative effect of this agent in breast cancer.	Curcumin	67-75	cyclin D1	Homo sapiens	96-105
29605511-0	2018	Tetrandrine inhibits deregulated cell cycle in pancreatic cancer cells: Differential regulation of p21Cip1/Waf1, p27Kip1 and cyclin D1.	tetrandrine	0-11	cyclin D1	Homo sapiens	125-134
29605511-4	2018	TET increased levels of p21Cip1/Waf1 and p27Kip1, had no effect on the levels of CDK4/6 proteins and decreased the levels of cyclin D1 and pRb proteins.	tetrandrine	0-3	cyclin D1	Homo sapiens	125-134
29605511-5	2018	TET resulted in changes in mRNA levels of cyclin D1 and p21Cip1/Waf1 but had no effect on the mRNA of p27Kip1.	tetrandrine	0-3	cyclin D1	Homo sapiens	42-51
29620174-10	2018	Finally, VAS2870 suppressed the proliferation of RPE cells, and led to G1-phase cell cycle arrest and a significant downregulation of the expression of cyclin D1.	3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine	9-16	cyclin D1	Homo sapiens	152-161
29702091-5	2018	Significantly, MALAT1 deletion sensitized HepG2 cells to 5-FU-induced cell cycle arrest in G1 phase, as evidenced by the significant reduction in Cyclin D1 and CDK4 and increase in p53, p21 and p27 protein levels.	Fluorouracil	57-61	cyclin D1	Homo sapiens	146-155
30197337-6	2018	Cyclin D1 was significantly correlated with MTV (r = 0.45, P = 0.03), TLG (r = 0.492, P = 0.01) and T-stage (r = 0.483, P = 0.02).	(5r)-3-Acetyl-4-Hydroxy-5-Methyl-5-[(1z)-2-Methylbuta-1,3-Dien-1-Yl]thiophen-2(5h)-One	70-73	cyclin D1	Homo sapiens	0-9
30197337-9	2018	Conclusion: Our results indicated that biomarkers such as cyclin D1 and Bcl-2 were correlated with measures such as MTV, TLG, and SUV in 18F-FDG PET/CT.	mtv	116-119	cyclin D1	Homo sapiens	58-67
30197337-9	2018	Conclusion: Our results indicated that biomarkers such as cyclin D1 and Bcl-2 were correlated with measures such as MTV, TLG, and SUV in 18F-FDG PET/CT.	(5r)-3-Acetyl-4-Hydroxy-5-Methyl-5-[(1z)-2-Methylbuta-1,3-Dien-1-Yl]thiophen-2(5h)-One	121-124	cyclin D1	Homo sapiens	58-67
30197337-9	2018	Conclusion: Our results indicated that biomarkers such as cyclin D1 and Bcl-2 were correlated with measures such as MTV, TLG, and SUV in 18F-FDG PET/CT.	Fluorodeoxyglucose F18	141-144	cyclin D1	Homo sapiens	58-67
30108651-0	2018	Bufadienolides from Venenum Bufonis Inhibit mTOR-Mediated Cyclin D1 and Retinoblastoma Protein Leading to Arrest of Cell Cycle in Cancer Cells.	Bufanolides	0-14	cyclin D1	Homo sapiens	58-67
29749557-3	2018	More in-depth research demonstrated that DIDS downregulated the protein expression levels of cyclin D1 and cyclin E, which are key proteins of the G1 phase.	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	41-45	cyclin D1	Homo sapiens	93-102
30001775-10	2018	Curcumin (0.6 muM) significantly reduced BrdU+-positive cells, declined the expression of CyclinD1, and enhanced cell apoptosis.	Curcumin	0-8	cyclin D1	Homo sapiens	90-98
29880532-7	2018	We identified a build-up of intracellular reactive oxygen species in the cancer cells that underwent senescence upon depletion of cyclin D1 but not in those cells where CDK4 was inhibited.	Reactive Oxygen Species	42-65	cyclin D1	Homo sapiens	130-139
29891980-6	2018	(-)-Gochnatiolide B induced G1 arrest which associated with SKP2 downregulation, leading to p27/Kip1 accumulation and downregulation of cyclin D1 in T24 cells.	gochnatiolide B	0-19	cyclin D1	Homo sapiens	136-145
29400636-7	2018	Consistently, western blotting showed that buformin activated AMPK and suppressed S6, cyclin D1, CDK4, and MMP9.	Buformin	43-51	cyclin D1	Homo sapiens	86-95
29858490-10	2018	We also found that the phenotypic alterations by miR-365 were partially due to downregulation of CCND1 and BCL2 oncogenes.	mir-365	49-56	cyclin D1	Homo sapiens	97-102
29710520-5	2018	The mRNA levels and protein levels of several key cell cycle relative proteins (cyclin D1 and CDK4) were also dramatically decreased during the process of G0/G1 arrest after the administration of Astragaloside IV.	astragaloside	196-209	cyclin D1	Homo sapiens	80-89
29873242-6	2018	Stachydrine promoted apoptosis and cyclin D1/p27Kip1-associated G0/G1 phase arrest in a CXCR4/ERK- and CXCR4/Akt-dependent manner.	stachydrine	0-11	cyclin D1	Homo sapiens	35-44
29266359-6	2018	Overexpression of miR-320 increased B cell proliferation and promoted cyclin D1 expression.	mir-320	18-25	cyclin D1	Homo sapiens	70-79
28833099-0	2018	Simvastatin induces G1 arrest by up-regulating GSK3beta and down-regulating CDK4/cyclin D1 and CDK2/cyclin E1 in human primary colorectal cancer cells.	Simvastatin	0-11	cyclin D1	Homo sapiens	81-90
28833099-7	2018	SIM suppressed cell growth and induced cell cycle G1 -arrest by suppressing the expression of CDK4/cyclin D1 and CDK2/cyclin E1, but elevating the expression of glycogen synthase kinase 3beta in CPs.	Simvastatin	0-3	cyclin D1	Homo sapiens	99-108
29741716-11	2018	Validation experiments also found that riboflavin depletion decreased p21 and p27 protein levels by ~20%, and increased cell cycle-related and expression-elevated protein in tumor (CREPT) protein expression &gt;2-fold, resulting in cyclin D1 and CDK4 levels being increased ~1.5-fold, and cell cycle acceleration.	Riboflavin	39-49	cyclin D1	Homo sapiens	232-241
30003065-9	2018	DHTS induced cell cycle arrest in the G0/G1 phase, which was mediated by downregulation of cyclin D1, cyclin A, cyclin E, CDK4, CDK2, c-Myc and p-Rb expression and with increased expression of the CDK inhibitor p21.	dhts	0-4	cyclin D1	Homo sapiens	91-100
29805678-15	2018	Induction of cyclin D1 and aromatase expression by 17beta-estradiol was also prevented by Somavert.	Estradiol	51-67	cyclin D1	Homo sapiens	13-22
29805688-3	2018	Propidium iodide staining analysis identified the cell cycle arrest of G1 phase and western blotting analysis demonstrated that the expression levels of cyclin D1, cyclin E2, cyclin A and cyclin B1 were decreased.	Propidium	0-16	cyclin D1	Homo sapiens	153-162
29932493-6	2018	In a separate experiment, we found that the application of norepinephrine or acetylcholine decreases the expression of cyclin D1, a gene necessary for cell cycle progression, in intestinal epithelial organoids compared with controls (P &lt; 0.05).	Norepinephrine	59-73	cyclin D1	Homo sapiens	119-128
29932493-6	2018	In a separate experiment, we found that the application of norepinephrine or acetylcholine decreases the expression of cyclin D1, a gene necessary for cell cycle progression, in intestinal epithelial organoids compared with controls (P &lt; 0.05).	Acetylcholine	77-90	cyclin D1	Homo sapiens	119-128
29654165-9	2018	Furthermore, overexpressed NEAT1 reduced the sensitivity of cisplatin (DDP) and inhibited DDP-induced apoptosis and cell cycle arrest via miR-34c The results in vivo also confirmed that knockdown of NEAT1 sensitized the OS cells to DPP-induced tumor regression, delayed the tumor growth with reduced levels of Ki-67, BCL-2, and cyclin D1 signals, suggesting that NEAT1 is an oncogene and chemotherapy resistant factor in OS.	Cisplatin	60-69	cyclin D1	Homo sapiens	328-337
29596834-8	2018	BRD4-regulated proteins, including c-Myc, Bcl-2 and cyclin D1, were significantly downregulated following AZD5153 treatment in TPC-1 and primary cancer cells.	AZD5153	106-113	cyclin D1	Homo sapiens	52-61
29596834-10	2018	BRD4-dependent proteins, Myc, Bcl-2 and cyclin D1, were also downregulated in AZD5153-treated tumor tissues.	AZD5153	78-85	cyclin D1	Homo sapiens	40-49
28835320-5	2018	Moreover, when CHIR-99021, a GSK3beta inhibitor, was added to baicalein-treated SiHa cells, the expression of cyclin D1 was recovered, and cell proliferation was promoted.	baicalein	62-71	cyclin D1	Homo sapiens	110-119
28835320-6	2018	In conclusion, these data indicated that baicalein suspended the cell cycle at the G0/G1 phase via the downregulation of cyclin D1 through the AKT-GSK3beta signaling pathway and further inhibited the proliferation of SiHa and HeLa cervical cancer cells.	baicalein	41-50	cyclin D1	Homo sapiens	121-130
29806073-5	2018	Furthermore, Taraxasterol upregulated Hint1 and Bax, but downregulated Bcl2 and cyclin D1 expression, accompanied by promoting the demethylation in the Hint1 promoter region in liver cancer cells.	taraxasterol	13-25	cyclin D1	Homo sapiens	80-89
29806073-6	2018	The effects of Taraxasterol were abrogated by Hint1 silencing and partially mitigated by Bax silencing, Bcl2 or cyclin D1 over-expression in HepG2 cells.	taraxasterol	15-27	cyclin D1	Homo sapiens	112-121
29806073-12	2018	Taraxasterol increases Hint1 levels to regulate Bax, Bcl2, and cyclinD1 expression.	taraxasterol	0-12	cyclin D1	Homo sapiens	63-71
29867331-9	2018	Moreover, VU0155041 treatment substantially blocked SHH-induced cyclin D1 expression and cell proliferation, while increasing TUNEL-positive cells and the activation of apoptosis-related proteins.	VU 0155041	10-19	cyclin D1	Homo sapiens	64-73
29737325-14	2018	Combination treatment with vemurafenib and AZD6244 inhibited cell growth and induced apoptosis by causing cell-cycle arrest, with the corresponding changes in the expression of the cell cycle regulators p27Kip1 and cyclin D1.	Vemurafenib	27-38	cyclin D1	Homo sapiens	215-224
29737325-14	2018	Combination treatment with vemurafenib and AZD6244 inhibited cell growth and induced apoptosis by causing cell-cycle arrest, with the corresponding changes in the expression of the cell cycle regulators p27Kip1 and cyclin D1.	AZD 6244	43-50	cyclin D1	Homo sapiens	215-224
29502166-7	2018	PFOA increased cyclin D1 and CDK4/6 levels, concomitant with a decrease in p27.	perfluorooctanoic acid	0-4	cyclin D1	Homo sapiens	15-24
29301388-9	2018	Immunoblot analysis data revealed that, in MCF-7 cell lines, PA treatment resulted in the dose-dependent (i) induction of p21WAF1/Cip1 and p27Kip1, (ii) downregulation of Cyclin dependent kinase (CDK) 4 and (iii) decrease in cyclin D1.	panduratin A	61-63	cyclin D1	Homo sapiens	225-234
29477054-6	2018	Furthermore, overexpression of TRIM37 obviously inhibited the protein expression levels of beta-catenin, c-Myc and cyclinD1 in PDGF-BB-stimulated ASMCs.	asmcs	146-151	cyclin D1	Homo sapiens	115-123
29743815-14	2018	Moreover, genistein, daidzein and ERB-041 treatment reduced p-FAK, p-PI3K, p-AKT, p-GSK3beta, p21 or cyclin D1 expression in ovarian cancer cells.	Genistein	10-19	cyclin D1	Homo sapiens	101-110
29743815-14	2018	Moreover, genistein, daidzein and ERB-041 treatment reduced p-FAK, p-PI3K, p-AKT, p-GSK3beta, p21 or cyclin D1 expression in ovarian cancer cells.	daidzein	21-29	cyclin D1	Homo sapiens	101-110
29743815-15	2018	Conclusion: Genistein, daidzein and ERB-041 decreased ovarian cancer cell migration, invasion, proliferation and sphere formation, and induced cell cycle arrest and apoptosis with altered FAK and PI3K/AKT/GSK signaling and p21/cyclin D1 expression, suggesting their roles on ovarian cancer cell metastasis, tumorigenesis and stem-like properties and their potential as alternative therapies for ovarian cancer patients.	Genistein	12-21	cyclin D1	Homo sapiens	227-236
29592859-7	2018	PAI-1 localization to SGs increases the translocation of cyclin D1 to the nucleus, promotes RB phosphorylation, and maintains a proliferative, non-senescent state.	Glycyrrhetinyl stearate	22-25	cyclin D1	Homo sapiens	57-66
29771440-0	2018	MiR-519d reduces the 5-fluorouracil resistance in colorectal cancer cells by down-regulating the expression of CCND1.	Fluorouracil	21-35	cyclin D1	Homo sapiens	111-116
29771440-4	2018	Dual luciferase assay was used to examine the effect of CCND1 on the sensitivity of cells to 5-Fu mediated by miR-519d.	Fluorouracil	93-97	cyclin D1	Homo sapiens	56-61
29771440-9	2018	si-CCND1 increased the sensitivity of colorectal cancer cells to 5-Fu.	Fluorouracil	65-69	cyclin D1	Homo sapiens	3-8
29393377-9	2018	Furthermore, overexpression of BCL6B resulted in upregulation of E-cadherin and downregulation of cyclin D1 and matrix metalloproteinase-9, which were strongly enhanced by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	172-180	cyclin D1	Homo sapiens	98-138
29578061-7	2018	Treatment of the liver cancer stem cells with mefloquine markedly decreased the potential to undergo self-renewal at 10 muM concentration after 48 h. The results from western blot analysis showed significantly higher expression of cancer stem cell molecules beta-catenin and cyclin D1 in LCSCs.	Mefloquine	46-56	cyclin D1	Homo sapiens	275-284
29578061-8	2018	Treatment of the LCSCs with various concentrations of mefloquine reduced the expression levels of beta-catenin and cyclin D1.	Mefloquine	54-64	cyclin D1	Homo sapiens	115-124
29517103-7	2018	In addition, lenvatinib inhibited EGFR, AKT and ERK1/2 phosphorylation and downregulated cyclin D1 in the ATC cells.	lenvatinib	13-23	cyclin D1	Homo sapiens	89-98
29517106-4	2018	Furthermore, vandetanib inhibited EGFR, AKT and ERK1/2 phosphorylation and downregulated cyclin D1 in ATC cells.	vandetanib	13-23	cyclin D1	Homo sapiens	89-98
29725405-6	2018	Consistently, there was a significant decrease in the expression of cell proliferation-associated proteins, including cyclin D1, cyclin-dependent kinase (Cdk)2 and Cdk4 in A431 cells treated with rosiglitazone.	Rosiglitazone	196-209	cyclin D1	Homo sapiens	118-127
29731854-6	2018	Additionally, western blot analysis identified that CTD inhibited the phosphatidylinositol 3-kinase (PI3K)/RAC serine/threonine protein kinase (Akt)/mechanistic target of rapamycin (mTOR) signaling pathway in NSCLC, demonstrating that the levels of phosphorylated (p-)Akt, p-mTOR, phosphorylated ribosomal p70S6 protein kinase (p-p70-S6K) and cyclin D1 were significantly decreased following treatment with CTD.	Cantharidin	52-55	cyclin D1	Homo sapiens	343-352
29731858-4	2018	The effects of lycopene and beta-carotene on the expression of PPARgamma, p21WAF1/CIP1, cyclin D1 and cyclooxygenase-2 (COX-2) were analyzed by western blotting.	beta Carotene	28-41	cyclin D1	Homo sapiens	88-97
29731858-7	2018	Lycopene and beta-carotene treatments upregulated the expression of PPARgamma and p21WAF1/CIP1, and downregulated the expression of cyclin D1 and COX-2.	Lycopene	0-8	cyclin D1	Homo sapiens	132-141
29731858-7	2018	Lycopene and beta-carotene treatments upregulated the expression of PPARgamma and p21WAF1/CIP1, and downregulated the expression of cyclin D1 and COX-2.	beta Carotene	13-26	cyclin D1	Homo sapiens	132-141
29731858-8	2018	These modulatory effects of the carotenoid treatments were suppressed by GW9662, suggesting that the inhibition of EC109 cell viability by lycopene and beta-carotene involves PPARgamma signaling pathways and the modulation of p21WAF1/CIP1, cyclin D1 and COX-2 expression.	Carotenoids	32-42	cyclin D1	Homo sapiens	240-249
29731858-8	2018	These modulatory effects of the carotenoid treatments were suppressed by GW9662, suggesting that the inhibition of EC109 cell viability by lycopene and beta-carotene involves PPARgamma signaling pathways and the modulation of p21WAF1/CIP1, cyclin D1 and COX-2 expression.	2-chloro-5-nitrobenzanilide	73-79	cyclin D1	Homo sapiens	240-249
29731858-8	2018	These modulatory effects of the carotenoid treatments were suppressed by GW9662, suggesting that the inhibition of EC109 cell viability by lycopene and beta-carotene involves PPARgamma signaling pathways and the modulation of p21WAF1/CIP1, cyclin D1 and COX-2 expression.	Lycopene	139-147	cyclin D1	Homo sapiens	240-249
29731858-8	2018	These modulatory effects of the carotenoid treatments were suppressed by GW9662, suggesting that the inhibition of EC109 cell viability by lycopene and beta-carotene involves PPARgamma signaling pathways and the modulation of p21WAF1/CIP1, cyclin D1 and COX-2 expression.	beta Carotene	152-165	cyclin D1	Homo sapiens	240-249
29724295-6	2018	Further, the expression levels of phosphorylated AKT, phosphorylated mTOR, P70 and CyclinD1 in the PI3K/AKT signaling pathway were obviously reduced in the JTC-801 treated SKOV3 group.	N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl)benzamide	156-163	cyclin D1	Homo sapiens	83-91
29335070-6	2018	However, Akt pathway was additionally involved in upregulated expression levels of cyclin D1 and cyclin E induced by CaS by activating 5-HT2BR.	cas	117-120	cyclin D1	Homo sapiens	83-92
29499919-9	2018	Furthermore, Wnt1, beta-Catenin, c-Myc and Cyclin D1 were significantly increased after US irradiation (all p &lt;0.05), and the enhancements of c-Myc and Cyclin D1 could be obviously impaired by the inhibitor ICG-001 (p &lt;0.05, p &lt;0.05), in accordance with decreased ALB and CK18 expression and glycogen content (all p &lt;0.05).	Indocyanine Green	210-213	cyclin D1	Homo sapiens	155-164
29499919-9	2018	Furthermore, Wnt1, beta-Catenin, c-Myc and Cyclin D1 were significantly increased after US irradiation (all p &lt;0.05), and the enhancements of c-Myc and Cyclin D1 could be obviously impaired by the inhibitor ICG-001 (p &lt;0.05, p &lt;0.05), in accordance with decreased ALB and CK18 expression and glycogen content (all p &lt;0.05).	Glycogen	301-309	cyclin D1	Homo sapiens	155-164
29693804-0	2018	Synergistic Growth Inhibitory Effects of Chrysin and Metformin Combination on Breast Cancer Cells through hTERT and Cyclin D1 Suppression Objective: To explore the possibility of a novel chemopreventive strategy for improving breast cancer treatment,the anticancer effects of a combination two natural compounds, Chrysin and Metformin, against T47D breast cancercells were investigated.	chrysin	41-48	cyclin D1	Homo sapiens	116-125
29693804-0	2018	Synergistic Growth Inhibitory Effects of Chrysin and Metformin Combination on Breast Cancer Cells through hTERT and Cyclin D1 Suppression Objective: To explore the possibility of a novel chemopreventive strategy for improving breast cancer treatment,the anticancer effects of a combination two natural compounds, Chrysin and Metformin, against T47D breast cancercells were investigated.	Metformin	53-62	cyclin D1	Homo sapiens	116-125
29693804-5	2018	Conclusion: The conmbinationof metformin and chrysin suppressing hTERT and cyclin D1 gene expression might offer an appropriate approach forbreast cancer therapy.	Metformin	31-40	cyclin D1	Homo sapiens	75-84
29695901-12	2018	Transfection of NOR1 overexpression plasmid raised cyclin D1 protein levels, which could be significant inhibited by NOR1-specific siRNA or a CDK4/6 inhibitor PD0332991.	palbociclib	159-168	cyclin D1	Homo sapiens	51-60
29477771-8	2018	Resveratrol treatment suppressed the CAF-CM-induced expression of Cyclin D1, c-Myc, MMP-2 and MMP-9.	Resveratrol	0-11	cyclin D1	Homo sapiens	66-75
29436583-9	2018	PD0332991 also inhibited CDK6-specific phosphorylation of retinoblastoma on Ser780, reduced the expression of cyclin D1, and induced expression of p53 and p27.	palbociclib	0-9	cyclin D1	Homo sapiens	110-119
29432993-6	2018	Oridonin also induced G2/M phase arrest in OSCC cells via down-regulating the G2/M transition-related proteins such as cyclin B1 or up-regulating cyclin D1, cyclin D3, P21, p-CDK1 and cyclin A2.	oridonin	0-8	cyclin D1	Homo sapiens	146-155
29421580-9	2018	Also, we found that ghrelin treatment inhibited UVB radiation- induced reduction of Wnt1, Wnt3a, Myc, and cyclin D1 at both the mRNA levels and the protein levels.	Ghrelin	20-27	cyclin D1	Homo sapiens	106-115
29240261-10	2018	We also found an additional mechanism for the dinaciclib-induced augmentation of apoptosis due to abrogation RAD51-cyclin D1 interaction, specifically proteolysis of the DNA repair proteins RAD51 and Ku80.	dinaciclib	46-56	cyclin D1	Homo sapiens	115-124
29414668-10	2018	In the same assay, garcinol down-regulated beta-catenin, Dvl2, Axin2, and cyclin D1 expressions in NSCLC-generated spheres, suggesting its ability to regulate the Wnt/beta-catenin signaling pathway.	garcinol	19-27	cyclin D1	Homo sapiens	74-83
29436653-6	2018	Mechanistically, 4-AP upregulated the phosphatase and tensin homolog (PTEN) and modulated the phosphoinositide 3-kinase/protein kinase B signaling pathway and its downstream cell cycle factors, including cyclin D1, cyclin-dependent kinase 4 and p21, as well as apoptosis-associated proteins B-cell lymphoma 2, pro-caspase 9, pro-caspase 3, cleaved caspase 9 and cleaved caspase 3.	4-Aminopyridine	17-21	cyclin D1	Homo sapiens	204-213
29436642-10	2018	Western blot analysis revealed that these synergistic effects of ruxolitinib and calcitriol were associated with reduced protein levels of JAK2, phosphorylated JAK2, c-Myc proto oncogene protein, cyclin-D1, apoptosis regulator Bcl-2 and Bcl-2-like protein 1, and with increased levels of caspase-3 and Bcl-2-associated agonist of cell death proteins.	ruxolitinib	65-76	cyclin D1	Homo sapiens	196-205
29436642-10	2018	Western blot analysis revealed that these synergistic effects of ruxolitinib and calcitriol were associated with reduced protein levels of JAK2, phosphorylated JAK2, c-Myc proto oncogene protein, cyclin-D1, apoptosis regulator Bcl-2 and Bcl-2-like protein 1, and with increased levels of caspase-3 and Bcl-2-associated agonist of cell death proteins.	Calcitriol	81-91	cyclin D1	Homo sapiens	196-205
29552167-8	2018	Cyclin D1 expression was decreased in all chemotherapy treatment groups; the most significant decrease was in A549 cells treated with nimotuzumab followed sequentially by cisplatin.	Cisplatin	171-180	cyclin D1	Homo sapiens	0-9
29505958-9	2018	In contrast, SK-N-AS cells show increased CCND1, phosphorylated RB and E2F1 in response to Wnt3a/Rspo2, consistent with their proliferative response, and these proteins are not increased in differentiating lines.	sk-n	13-17	cyclin D1	Homo sapiens	42-47
29393444-5	2018	This over-proliferative activity induced by TSA may be associated with abnormal activation of JAK2/STAT3 signaling, which can be strengthened by interleukin-6 (IL-6), a STAT3-upstream inducer, resulting in enhanced expression of STAT3-downstream target genes including c-Myc, c-Src, HIF-1alpha, and CCND1.	trichostatin A	44-47	cyclin D1	Homo sapiens	299-304
29356571-10	2018	In addition, EO-PCL-PEG electrospun nanofibrous mats significantly upregulated the expression levels of cell cycle regulated genes (Cyclin D1, pRb, and P53) and stemness markers (Nanog, OCT-4, Rex-1, and Sox-2) than PCL-PEG nanofiber and tissue culture polystyrene in 7 and 14 days of cell culture.	eo-pcl-peg	13-23	cyclin D1	Homo sapiens	132-141
29356571-10	2018	In addition, EO-PCL-PEG electrospun nanofibrous mats significantly upregulated the expression levels of cell cycle regulated genes (Cyclin D1, pRb, and P53) and stemness markers (Nanog, OCT-4, Rex-1, and Sox-2) than PCL-PEG nanofiber and tissue culture polystyrene in 7 and 14 days of cell culture.	pcl-peg	16-23	cyclin D1	Homo sapiens	132-141
29765996-4	2018	Cyclin D1 is overexpressed in ESCC and curcumin may change its expression.	Curcumin	39-47	cyclin D1	Homo sapiens	0-9
29765996-5	2018	Methods: In this study, the effect of SinaCurcumin , a novel nano-micelle product containing 80 mg curcumin, on the growth of KYSE-30 cells and expression of cyclin D1, was investigated.	sinacurcumin	38-50	cyclin D1	Homo sapiens	158-167
29765996-7	2018	Results: Nano-curcumin increased cell cytotoxicity, decreased IC50, and down-regulated of cyclin D1.	Curcumin	14-22	cyclin D1	Homo sapiens	90-99
29765996-9	2018	Conclusion: Nano-curcumin suppressed proliferation of KYSE-30 cells and expression of cyclin D1 although its use in combination with other chemotherapeutic agents requires further testing.	Curcumin	17-25	cyclin D1	Homo sapiens	86-95
29973327-0	2018	[Lycorine inhibits the proliferation and promotes apoptosis of SGC-7901 gastric cancer cells by downregulating expression of cyclin D1].	lycorine	1-9	cyclin D1	Homo sapiens	125-134
29973327-6	2018	The cell cycle was arrested in G0/G1 phase, the apoptosis rate of cells increased, and the level of cyclin D1 mRNA and protein decreased significantly 48 hours after the treatment with 13 mumol/L lycorine.	lycorine	196-204	cyclin D1	Homo sapiens	100-109
29725496-3	2018	In this study, we found that melatonin impaired the proliferation and apoptosis resistance of oral cancer cells by inactivating ROS-dependent Akt signaling, involving in downregulation of cyclin D1, PCNA, and Bcl-2 and upregulation of Bax.	Melatonin	29-38	cyclin D1	Homo sapiens	188-197
29596381-6	2018	In comparison with normally cultured cells, the total cell number in resveratrol-treated THJ-16T and THJ-21T cultures significantly decreased (p &lt; 0.05), and this effect was accompanied by reduced Cyclin D1 immuno-labeling, increased apoptotic fractions, and distinct caspase-3 activation.	Resveratrol	69-80	cyclin D1	Homo sapiens	200-209
29725496-3	2018	In this study, we found that melatonin impaired the proliferation and apoptosis resistance of oral cancer cells by inactivating ROS-dependent Akt signaling, involving in downregulation of cyclin D1, PCNA, and Bcl-2 and upregulation of Bax.	Reactive Oxygen Species	128-131	cyclin D1	Homo sapiens	188-197
29266182-10	2018	Transfection experiments using enzalutamide-sensitive and enzalutamide-resistant LNCaP cells confirmed the involvement of SMAD family member 3, a key mediator of the TGFbeta pathway, and of CCND1 in resistance to enzalutamide treatment.	enzalutamide	58-70	cyclin D1	Homo sapiens	190-195
29568320-3	2018	The enzymes responsible for arginine methylation, protein arginine methyltransferases (PRMTs), have been shown to methylate or associate with important regulatory proteins of the cell cycle and DNA damage repair pathways, such as cyclin D1, p53, p21 and the retinoblastoma protein.	Arginine	28-36	cyclin D1	Homo sapiens	230-239
29266182-10	2018	Transfection experiments using enzalutamide-sensitive and enzalutamide-resistant LNCaP cells confirmed the involvement of SMAD family member 3, a key mediator of the TGFbeta pathway, and of CCND1 in resistance to enzalutamide treatment.	enzalutamide	58-70	cyclin D1	Homo sapiens	190-195
29409027-2	2018	Recently, we have demonstrated that isorhapontigenin (ISO), a new derivative isolated from the Chinese herb Gnetum cleistostachyum, effectively induces cell-cycle arrest at the G0/G1 phase and inhibits anchorage-independent cell growth through the miR-137/Sp1/cyclin D1 axis in human MIBC cells.	isorhapontigenin	36-52	cyclin D1	Homo sapiens	260-269
29522490-8	2018	Some bioactive compounds from EEAC, such as cordycepin and zhankuic acid A, were demonstrated to reduce the protein expressions of matrix metalloproteinase (MMP)-9 and cyclin D1 in A549 cells.	eeac	30-34	cyclin D1	Homo sapiens	168-177
29522490-8	2018	Some bioactive compounds from EEAC, such as cordycepin and zhankuic acid A, were demonstrated to reduce the protein expressions of matrix metalloproteinase (MMP)-9 and cyclin D1 in A549 cells.	cordycepin	44-54	cyclin D1	Homo sapiens	168-177
29522490-8	2018	Some bioactive compounds from EEAC, such as cordycepin and zhankuic acid A, were demonstrated to reduce the protein expressions of matrix metalloproteinase (MMP)-9 and cyclin D1 in A549 cells.	zhankuic acid A	59-74	cyclin D1	Homo sapiens	168-177
28624869-6	2018	Furthermore, the H2O2-induced decrease of gene and protein expressions of beta-catenin and cyclin D1 in the Wnt/beta-catenin signaling pathway was successfully rescued by the CeO2 incorporated HA coatings.	Hydrogen Peroxide	17-21	cyclin D1	Homo sapiens	91-100
29305319-7	2018	AKAP12"s scaffolding activity for protein kinase C/cyclin-D1 decreased in ethanol-treated HSCs but not hepatocytes.	Ethanol	74-81	cyclin D1	Homo sapiens	51-60
29456111-3	2018	Methyllucidone decreased the expression levels of STAT3 target genes, such as cyclin D1, cyclin A, Bcl-2, Mcl-1, and survivin.	methyllucidone	0-14	cyclin D1	Homo sapiens	78-87
29355544-5	2018	Additionally, CyclinD1 and B cell lymphoma-2 expression were suppressed and Bcl-2-like protein-4 expression was enhanced after quercetin treatment.	Quercetin	127-136	cyclin D1	Homo sapiens	14-22
28775176-8	2018	Moreover, a known miR-28-5p target, CCND1, was expressed at higher levels in HMCLs with LPP/miR-28 methylation than those without, consistent with a tumour suppressor role of miR-28-5p in myeloma.	hmcls	77-82	cyclin D1	Homo sapiens	36-41
29520172-9	2018	Fluvastatin repressed cell cycle regulatory genes cyclin D1 and Cdk4 and augmented cyclin-dependent kinase inhibitors p27 and p21 in AGE-induced VSMCs.	Fluvastatin	0-11	cyclin D1	Homo sapiens	50-59
29528074-6	2018	An NFAT inhibitor (CsA) and NF-kappaB inhibitor (PDTC) all markedly reduced Cyclin D1 protein expression.	Cyclosporine	19-22	cyclin D1	Homo sapiens	76-85
29528074-0	2018	Arsenite increases Cyclin D1 expression through coordinated regulation of the Ca2+/NFAT2 and NF-kappaB pathways via ERK/MAPK in a human uroepithelial cell line.	arsenite	0-8	cyclin D1	Homo sapiens	19-28
29528074-5	2018	Cyclin D1 is known as a proto-oncogene and the level of this protein was increased in SV-HUC-1 cells treated with arsenite for 24 h and long-term.	arsenite	114-122	cyclin D1	Homo sapiens	0-9
29344652-0	2018	Chrysophanol inhibits proliferation and induces apoptosis through NF-kappaB/cyclin D1 and NF-kappaB/Bcl-2 signaling cascade in breast cancer cell lines.	chrysophanic acid	0-12	cyclin D1	Homo sapiens	76-85
29344652-5	2018	The expression of cell cycle-associated cyclin D1 and cyclin E were downregulated while p27 expression was upregulated following chrysophanol treatment at the mRNA, and protein levels.	chrysophanic acid	129-141	cyclin D1	Homo sapiens	40-49
29363722-8	2018	Administration of beta-elemene induced G1 phase cell-cycle arrest, as demonstrated by the upregulation of P15 expression and the downregulation of Cyclin D1 expression.	beta-elemene	18-30	cyclin D1	Homo sapiens	147-156
29363722-11	2018	Western blotting demonstrated that beta-elemene reduced the expression levels of beta-catenin and its downstream target molecule TCF7, thus resulting in reduced levels of their target proteins, including c-Myc, Cyclin D1, Bax and MMP-2 in cervical cancer cells.	beta-elemene	35-47	cyclin D1	Homo sapiens	211-220
29344638-8	2018	In addition, we found that garcinone C stimulated the expression levels of ATR and 4E-BP1, while efficiently inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, cdc2, CDK7 and Stat3.	garcinone C	27-38	cyclin D1	Homo sapiens	156-165
29344640-6	2018	When EGFR protein expression was suppressed, PI3K, p-Akt, p-JAK2 and p-STAT3, decreased cyclin D1 and increased Bax protein expression in cisplatin-induced A549 cells by over-regulation of microRNA-133b.	Cisplatin	138-147	cyclin D1	Homo sapiens	88-97
29496041-4	2018	Formalin-fixed, paraffin-embedded cancer tissues were subjected to histopathological evaluation, DNA quality control, HPV-DNA detection, and p16INK4a/pRb/p53/Cyclin-D1 immunohistochemistry.	Formaldehyde	0-8	cyclin D1	Homo sapiens	158-167
29483552-2	2018	TGF-beta1 reduced microRNA-206 (miR-206) level by activating Smad2/3, and this in turn up-regulated histone deacetylase 4 (HDAC4) and consequently increased cyclin D1 protein leading to ASMCs proliferation.	asmcs	186-191	cyclin D1	Homo sapiens	157-166
29483552-5	2018	Our study suggests that activation of AMPK modulates miR-206/HDAC4/cyclin D1 signaling pathway, particularly targeting on HDAC4, to suppress ASMCs proliferation and therefore has a potential value in the prevention and treatment of asthma by alleviating airway remodeling.	asmcs	141-146	cyclin D1	Homo sapiens	67-76
29472557-6	2018	Metformin reduced cyclin D1 expression and RB, STAT3, STAT5, ERK1/2 and p70S6K phosphorylation.	Metformin	0-9	cyclin D1	Homo sapiens	18-27
29511436-4	2018	Under the basal condition, DHA significantly retarded the cell cycle progression as shown by decreased cell percentage in S phase and increased cell percentage in G1/G0 phases in line with reduced cell cycle proteins cyclin A2 and cyclin D1.	artenimol	27-30	cyclin D1	Homo sapiens	231-240
29599917-6	2018	The combination of EGF and PGE2 prolongs nuclear EGFR transcriptional activity manifested by the upregulation of CCND1, PTGS2, MYC and NOS2 mRNA levels and potentiates nuclear EGFR-induced NSCLC cell proliferation.	Dinoprostone	27-31	cyclin D1	Homo sapiens	113-118
29445224-7	2018	NBT induced cell cycle arrest in the G0/G1 phase by decreasing the expression of cyclin D1.	Nitroblue Tetrazolium	0-3	cyclin D1	Homo sapiens	81-90
29552199-6	2018	In addition, the expression of the proapoptotic molecules caspase-3 and caspase-8 was significantly upregulated, and the expression of the antiapoptotic molecule MCL1 and the cell cycle-associated cyclin D1 was downregulated in sorafenib-treated NB4 cells compared with untreated cells.	Sorafenib	228-237	cyclin D1	Homo sapiens	197-206
29552215-8	2018	Additionally, levels of phosphorylated RAC serine/threonine-protein kinase (p-AKT), p-mechanistic target of rapamycin, p70-S6 kinase and cyclin D1 was decreased in the telmisartan-treated group.	Telmisartan	168-179	cyclin D1	Homo sapiens	137-146
29059158-0	2018	RAF inhibitor LY3009120 sensitizes RAS or BRAF mutant cancer to CDK4/6 inhibition by abemaciclib via superior inhibition of phospho-RB and suppression of cyclin D1.	LY3009120	14-23	cyclin D1	Homo sapiens	154-163
29059158-8	2018	The combinatory treatment cooperatively demonstrated more complete inhibition of Rb phosphorylation, and LY3009120 suppressed the cyclin D1 upregulation mediated by abemaciclib.	LY3009120	105-114	cyclin D1	Homo sapiens	130-139
29059158-10	2018	Importantly, the more complete phospho-Rb inhibition and cyclin D1 suppression by LY3009120 and abemaciclib combination led to more significant cell cycle G0/G1 arrest of tumor cells.	LY3009120	82-91	cyclin D1	Homo sapiens	57-66
29556338-0	2018	Elevated Expression of miR302-367 in Endothelial Cells Inhibits Developmental Angiogenesis via CDC42/CCND1 Mediated Signaling Pathways.	mir302	23-29	cyclin D1	Homo sapiens	101-106
29177689-4	2018	In this study, we determined Cyclin D1 expression in residual BC after NACT.	nact	71-75	cyclin D1	Homo sapiens	29-38
29218545-10	2018	In addition, we found that the application of BAY606583 led to CSC cell cycle arrest and apoptosis through the cyclin-D1/Cdk-4 and Bax/Bcl-2 pathways, respectively.	bay606583	46-55	cyclin D1	Homo sapiens	111-120
29134746-5	2018	Using the PPARalpha agonist fenofibrate, we found that fenofibrate increased Hep3B cell proliferation efficiency by increasing cell cycle proteins, such as cyclin D1 and PCNA, and inhibiting p27 and caspase 3 expressions.	Fenofibrate	55-66	cyclin D1	Homo sapiens	156-165
29135079-6	2018	After based on the MTT assay, two IP concentrations of 10-11 and 10-8 M were selected and the protein expressions of cyclin D1, cyclin E1, p21, and p27 decreased in response to IP.	monooxyethylene trimethylolpropane tristearate	19-22	cyclin D1	Homo sapiens	117-126
29434772-0	2018	Transcription activated p73-modulated cyclin D1 expression leads to doxorubicin resistance in gastric cancer.	Doxorubicin	68-79	cyclin D1	Homo sapiens	38-47
29434772-6	2018	Western blot results revealed that cyclin D1 was upregulated in Dox-resistant cells, whereas inhibition or depletion of cyclin D1 re-sensitized the resistant cells to Dox treatment, which indicated that the induction of cyclin D1 expression was a result of the Dox resistance in GC cells.	Doxorubicin	64-67	cyclin D1	Homo sapiens	35-44
29434772-6	2018	Western blot results revealed that cyclin D1 was upregulated in Dox-resistant cells, whereas inhibition or depletion of cyclin D1 re-sensitized the resistant cells to Dox treatment, which indicated that the induction of cyclin D1 expression was a result of the Dox resistance in GC cells.	Doxorubicin	167-170	cyclin D1	Homo sapiens	120-129
29434772-6	2018	Western blot results revealed that cyclin D1 was upregulated in Dox-resistant cells, whereas inhibition or depletion of cyclin D1 re-sensitized the resistant cells to Dox treatment, which indicated that the induction of cyclin D1 expression was a result of the Dox resistance in GC cells.	Doxorubicin	167-170	cyclin D1	Homo sapiens	120-129
29434772-6	2018	Western blot results revealed that cyclin D1 was upregulated in Dox-resistant cells, whereas inhibition or depletion of cyclin D1 re-sensitized the resistant cells to Dox treatment, which indicated that the induction of cyclin D1 expression was a result of the Dox resistance in GC cells.	Doxorubicin	167-170	cyclin D1	Homo sapiens	120-129
29434772-6	2018	Western blot results revealed that cyclin D1 was upregulated in Dox-resistant cells, whereas inhibition or depletion of cyclin D1 re-sensitized the resistant cells to Dox treatment, which indicated that the induction of cyclin D1 expression was a result of the Dox resistance in GC cells.	Doxorubicin	167-170	cyclin D1	Homo sapiens	120-129
29434772-8	2018	Overall, the present study data provided a rational strategy to overcome the Dox resistance in GC treatment by inhibiting cyclin D1 expression.	Doxorubicin	77-80	cyclin D1	Homo sapiens	122-131
29103775-0	2018	Cyclin D1 promoter -56 and -54bp CpG un-methylation predicts invasive progression in arsenic-induced Bowen"s disease.	Arsenic	85-92	cyclin D1	Homo sapiens	0-9
29207109-9	2018	In addition, 14-3-3beta knockdown significantly decreased the protein expression levels of beta-catenin, cyclin D1, v-myc avian myelocytomatosis viral oncogene homolog and matrix metallopeptidase 9 in osteosarcoma MG63 cells.	3beta	18-23	cyclin D1	Homo sapiens	105-114
29673455-7	2018	Results Compared with beta-lapachone or NVP-BEZ235 treatment, the combination of beta-lapachone and NVP-BEZ235 showed more prominent inhibitory effect on the proliferation and colony formation of BGC-823 cells.The most effective suppression on the expressions of p-AKT, p-NF-kappaB, p-ERK and cyclin D1 was observed in the combination therapy.	beta-lapachone	81-95	cyclin D1	Homo sapiens	293-302
29673455-7	2018	Results Compared with beta-lapachone or NVP-BEZ235 treatment, the combination of beta-lapachone and NVP-BEZ235 showed more prominent inhibitory effect on the proliferation and colony formation of BGC-823 cells.The most effective suppression on the expressions of p-AKT, p-NF-kappaB, p-ERK and cyclin D1 was observed in the combination therapy.	dactolisib	104-110	cyclin D1	Homo sapiens	293-302
29673455-10	2018	Conclusion beta-lapachone combined with NVP-BEZ235 can effectively inhibit the proliferation of BGC-823 cells, which may be related to the down-regulation of p-AKT, p-NF-kappaB, p-ERK and cyclin D1.	beta-lapachone	11-25	cyclin D1	Homo sapiens	188-197
29673455-10	2018	Conclusion beta-lapachone combined with NVP-BEZ235 can effectively inhibit the proliferation of BGC-823 cells, which may be related to the down-regulation of p-AKT, p-NF-kappaB, p-ERK and cyclin D1.	dactolisib	44-50	cyclin D1	Homo sapiens	188-197
29528074-7	2018	Treatment with U0126 also significantly decreased Cyclin D1 protein expression while JNK and p38 inhibitors did not attenuate the arsenite-associated increase in Cyclin D1 protein expression.	U 0126	15-20	cyclin D1	Homo sapiens	50-59
29528074-8	2018	The results suggest that regulation of Cyclin D1 protein expression by arsenite in SV-HUC-1 cells is dependent on ERK/NFAT2 and ERK/NF-kappaB, but is not dependent on JNK or p38.	arsenite	71-79	cyclin D1	Homo sapiens	39-48
29554905-9	2018	TC-HW decreased cyclin D1 protein level through cyclin D1 degradation via GSK3beta-dependent threonine-286 (T286) phosphorylation of cyclin D1, indicating that cyclin D1 degradation may contribute to TC-HW-mediated decrease of cyclin D1 protein level.	Threonine	93-102	cyclin D1	Homo sapiens	16-25
29554905-9	2018	TC-HW decreased cyclin D1 protein level through cyclin D1 degradation via GSK3beta-dependent threonine-286 (T286) phosphorylation of cyclin D1, indicating that cyclin D1 degradation may contribute to TC-HW-mediated decrease of cyclin D1 protein level.	C.I. Basic Blue 54	108-112	cyclin D1	Homo sapiens	16-25
29554905-9	2018	TC-HW decreased cyclin D1 protein level through cyclin D1 degradation via GSK3beta-dependent threonine-286 (T286) phosphorylation of cyclin D1, indicating that cyclin D1 degradation may contribute to TC-HW-mediated decrease of cyclin D1 protein level.	tc-hw	0-5	cyclin D1	Homo sapiens	16-25
29554905-9	2018	TC-HW decreased cyclin D1 protein level through cyclin D1 degradation via GSK3beta-dependent threonine-286 (T286) phosphorylation of cyclin D1, indicating that cyclin D1 degradation may contribute to TC-HW-mediated decrease of cyclin D1 protein level.	tc-hw	0-5	cyclin D1	Homo sapiens	48-57
29554905-9	2018	TC-HW decreased cyclin D1 protein level through cyclin D1 degradation via GSK3beta-dependent threonine-286 (T286) phosphorylation of cyclin D1, indicating that cyclin D1 degradation may contribute to TC-HW-mediated decrease of cyclin D1 protein level.	tc-hw	0-5	cyclin D1	Homo sapiens	48-57
29554905-9	2018	TC-HW decreased cyclin D1 protein level through cyclin D1 degradation via GSK3beta-dependent threonine-286 (T286) phosphorylation of cyclin D1, indicating that cyclin D1 degradation may contribute to TC-HW-mediated decrease of cyclin D1 protein level.	tc-hw	0-5	cyclin D1	Homo sapiens	48-57
29370087-4	2018	A study of the mechanisms indicated that BOS-102 could significantly block cell proliferation in human A549 lung cancer cells and effectively induce G0/G1 cell cycle arrest via targeting cyclin D1 and cyclin-dependent kinase 4 (CDK4).	BOS-102	41-48	cyclin D1	Homo sapiens	187-196
29554905-9	2018	TC-HW decreased cyclin D1 protein level through cyclin D1 degradation via GSK3beta-dependent threonine-286 (T286) phosphorylation of cyclin D1, indicating that cyclin D1 degradation may contribute to TC-HW-mediated decrease of cyclin D1 protein level.	tc-hw	0-5	cyclin D1	Homo sapiens	48-57
29433670-15	2018	Moreover, genistein inhibited the phosphorylation of signal transducer and activator of transcription STAT3 proteins and downregulated the expression of survivin, cyclin D1 and ALDH1A1 in Mia-PaCa2 cells in a dose dependent manner.	Genistein	10-19	cyclin D1	Homo sapiens	163-172
29159499-6	2018	Analysis of promoter methylation status of 22 cell cycle related genes in NB4 revealed that CCND1, CCNE1, CCNF, CDKN1A, GADD45alpha, and RBL1 genes were methylated 60.7, 84.6, 58.6, 8.7, 33.4, and 73.7%, respectively, that after treatment with 2 muM ATO for 48 h, turn into 0.6, 13.8, 0.1, 6.6, 10.7, and 54.5% methylated.	Arsenic Trioxide	250-253	cyclin D1	Homo sapiens	92-97
28684297-0	2018	Curcumol induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3beta/cyclin D1 pathway.	curcumol	0-8	cyclin D1	Homo sapiens	103-112
28684297-13	2018	RT-qPCR and Western blot data showed that curcumol enhanced the expression of GSK3beta, P27, p21 and P16, and decreased the levels of PI3K, phosphorylated Akt (p-Akt), cyclin D1, CDK4, cyclin E and CDK2.	curcumol	42-50	cyclin D1	Homo sapiens	168-177
28684297-16	2018	CONCLUSIONS: Curcumol caused cell cycle arrest at the G0/G1 phase by ROS production and Akt/ GSK3beta/cyclin D1 pathways inactivation, indicating the potential of curcumol in the prevention of colon cancer carcinogenesis.	curcumol	13-21	cyclin D1	Homo sapiens	102-111
28684297-16	2018	CONCLUSIONS: Curcumol caused cell cycle arrest at the G0/G1 phase by ROS production and Akt/ GSK3beta/cyclin D1 pathways inactivation, indicating the potential of curcumol in the prevention of colon cancer carcinogenesis.	curcumol	163-171	cyclin D1	Homo sapiens	102-111
29053388-7	2018	The cells treated with 5-FU or IRINO exhibited several hallmarks of SIPS: growth arrest, increased size and granularity, polyploidization, augmented activity of the SA-beta-galactosidase, accumulation of P21 and CYCLIN D1 proteins, and the senescence-associated secretory phenotype.	Fluorouracil	23-27	cyclin D1	Homo sapiens	212-221
29159499-8	2018	ATO induced the expression of CCND1, CCNE1, and GADD45alpha genes, suppressed the expression of CCNF and CDKN1A genes, which were consistent with decreased number of cells in G1 and S phases and increased number of cells in G2/M phase.	Arsenic Trioxide	0-3	cyclin D1	Homo sapiens	30-35
29203243-8	2018	Notably, we found that rottlerin upregulated DDX3 expression and subsequently downregulated Cyclin D1 expression and increased p21 level.	rottlerin	23-32	cyclin D1	Homo sapiens	92-101
29866018-8	2018	RESULTS: Pe-A effectively inhibited proliferation, with IC50 values was 22.33 muM for 72 h. Mechanistic studies revealed that Pe-A caused cell cycle arrest at the G0-G1 phase by decreasing cyclinD1 expression and induced apoptosis through accelerating the mitochondrial apoptotic pathway.	peniciketal A	9-13	cyclin D1	Homo sapiens	189-197
29866018-8	2018	RESULTS: Pe-A effectively inhibited proliferation, with IC50 values was 22.33 muM for 72 h. Mechanistic studies revealed that Pe-A caused cell cycle arrest at the G0-G1 phase by decreasing cyclinD1 expression and induced apoptosis through accelerating the mitochondrial apoptotic pathway.	peniciketal A	126-130	cyclin D1	Homo sapiens	189-197
30489168-5	2018	Results were shown that Cyclin-D1 and beta-catenin gene expression was significantly increased in those cells treated by poly-P.	Polyphosphates	121-127	cyclin D1	Homo sapiens	24-33
29793319-6	2018	The results indicated that oroxyloside significantly suppressed the proliferation of human glioma cells through inducing cell cycle arrest at G0/G1 phase through reducing Cyclin D1 and cyclin-dependent kinase 2 (CDK2) while enhancing p53 and p21 expressions.	oroxylin A-7-O-glucuronide	27-38	cyclin D1	Homo sapiens	171-180
29793319-9	2018	In vivo, oroxyloside administration significantly inhibited the glioma cell xenograft tumorigenesis through various signaling pathways, including suppression of Cyclin D1/CDK2 and ECM pathways, as well as potentiation of p53/p21 and Caspases pathways.	oroxylin A-7-O-glucuronide	9-20	cyclin D1	Homo sapiens	161-170
29099263-8	2018	Taken together, the results indicated that serum shock synchronization induced a circadian oscillation in mTOR activity in MCF-7 cells, which rhythmically regulated the synthesis or phosphorylation of key G1 progression proteins, such as Cyclin D1 and phosphorylated RB, ultimately resulting in different G0/G1 blockage efficiency according to different EV administration timing.	Everolimus	354-356	cyclin D1	Homo sapiens	238-247
30355923-13	2018	In addition, Erinacine was found to decrease the mitochondrial membrane potential, expression of PI3K, Akt, GSK-3beta, CyclinD1, Vimentin, beta-catenin, and Bcl-2, cell proliferation, colony formation ability, migration, invasion, and xenograft tumor size, while E-cadherin, Bax, and caspase-9 expression, and cell apoptosis were elevated in a dose-dependent manner.	erinacine S	13-22	cyclin D1	Homo sapiens	119-127
29969371-6	2018	Further studies showed that the combinations of cladribine and entinostat as compared to either agent alone more potently induced mitotic catastrophe in the MM cells, and resulted in a marked increase of the cells at G1 phase associated with decrease of Cyclin D1 and E2F-1 expression and upregulation of p21waf-1.	Cladribine	48-58	cyclin D1	Homo sapiens	254-263
29969371-6	2018	Further studies showed that the combinations of cladribine and entinostat as compared to either agent alone more potently induced mitotic catastrophe in the MM cells, and resulted in a marked increase of the cells at G1 phase associated with decrease of Cyclin D1 and E2F-1 expression and upregulation of p21waf-1.	entinostat	63-73	cyclin D1	Homo sapiens	254-263
30101722-8	2018	After treatment with paclitaxel, cyclin D1 and CDK4 protein levels were similar to control values; meanwhile, cylinE1 and CDK2 protein amounts were reduced, with increased cyclin B1 levels, compared with control values (p&lt;0.05).	Paclitaxel	21-31	cyclin D1	Homo sapiens	33-42
30497066-10	2018	The potential anti-GBM role of peiminine might involve cell cycle arrest and autophagic flux blocking via changes in expression of the cyclin D1/CDK network, p62 and LC3.	peiminine	31-40	cyclin D1	Homo sapiens	135-144
30562739-0	2018	Inhibition of Cyclin D1 Expression in Human Glioblastoma Cells is Associated with Increased Temozolomide Chemosensitivity.	Temozolomide	92-104	cyclin D1	Homo sapiens	14-23
30562739-7	2018	Forced inhibition of CCND1 increased temozolomide efficacy in U251 and SHG-44 cells.	Temozolomide	37-49	cyclin D1	Homo sapiens	21-26
30562739-8	2018	After CCND1 overexpression, the temozolomide efficacy decreased in U251 and SHG-44 cells.	Temozolomide	32-44	cyclin D1	Homo sapiens	6-11
30562739-9	2018	Colony survival assay and apoptosis analysis confirmed that CCND1 inhibition renders cells more sensitive to temozolomide treatment and temozolomide-induced apoptosis in U251 and SHG-44 cells.	Temozolomide	109-121	cyclin D1	Homo sapiens	60-65
30562739-9	2018	Colony survival assay and apoptosis analysis confirmed that CCND1 inhibition renders cells more sensitive to temozolomide treatment and temozolomide-induced apoptosis in U251 and SHG-44 cells.	Temozolomide	136-148	cyclin D1	Homo sapiens	60-65
30562739-10	2018	Inhibition of P-gp (MDR1) by Tariquidar overcomes the effects of CCND1 overexpression on inhibiting temozolomide-induced apoptosis.	Temozolomide	100-112	cyclin D1	Homo sapiens	65-70
30562739-11	2018	Inhibition of CCND1 inhibited cell growth in vitro and in vivo significantly more effectively after temozolomide treatments than single temozolomide treatments.	Temozolomide	100-112	cyclin D1	Homo sapiens	14-19
30562739-11	2018	Inhibition of CCND1 inhibited cell growth in vitro and in vivo significantly more effectively after temozolomide treatments than single temozolomide treatments.	Temozolomide	136-148	cyclin D1	Homo sapiens	14-19
29794421-9	2018	Our results revealed that some genes with high expression in colorectal cancer tissues were downregulated by cobimetinib in HCT116 cells, including CCND1, E2F1, CDC25C, CCNE2, MYC, and PCNA.	cobimetinib	109-120	cyclin D1	Homo sapiens	148-153
29692251-10	2018	RESULTS: Artesunate suppressed the phosphorylation of GSK3beta at S9, and lowered the protein level of beta-catenin and its downstream targets (c-Myc, cyclin D1).	Artesunate	9-19	cyclin D1	Homo sapiens	151-160
29269566-7	2018	In our TC xenograft model, the combination of Vemurafenib and Bortezomib significantly reduced tumor size (P &lt; 0.05) and expression of the markers of cell growth and proliferation, Ki-67 and cyclin D1 (P &lt; 0.001), when compared to monotherapy.	Vemurafenib	46-57	cyclin D1	Homo sapiens	194-203
30216786-2	2018	With retinoic acid (RA) induction, a high percentage of cells were found to be arrested at the G0/G1 phase, with decreased levels of cyclinD1, CDK4, phosphorylation status of pRb and E2F1, in addition to an elevated level of p27.	Tretinoin	5-18	cyclin D1	Homo sapiens	133-141
29269566-7	2018	In our TC xenograft model, the combination of Vemurafenib and Bortezomib significantly reduced tumor size (P &lt; 0.05) and expression of the markers of cell growth and proliferation, Ki-67 and cyclin D1 (P &lt; 0.001), when compared to monotherapy.	Bortezomib	62-72	cyclin D1	Homo sapiens	194-203
29179029-0	2018	3EZ, 20Ac-ingenol induces cell-specific apoptosis in cyclin D1 over-expression through the activation of ATR and downregulation of p-Akt.	3EZ, 20Ac-ingenol	0-17	cyclin D1	Homo sapiens	53-62
29109039-7	2018	The expression of cyclin D1, CDK4, CDK6 and p-Rb were markedly decreased in cells treated with PL at 40 muM.	piperlonguminine	95-97	cyclin D1	Homo sapiens	18-27
28815764-10	2018	Interestingly, the highest percentages of PD-L1-positive TCs with the three antibodies were found in samples with cyclin-dependent kinase 6 (CDK6) amplification, with high amplification of proto-oncogene C-Myc (CMYC) or with cyclin D1-PI3 kinase subunit alpha (CCND1-PIK3CA) co-amplification.	9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide	57-60	cyclin D1	Homo sapiens	261-266
29179029-5	2018	The DDR induced during the S-phase with 3EZ, 20Ac-ingenol treatment was increased by the intra S-phase checkpoint response that was triggered by the loss of nuclear cyclin D1 regulation in BALL-1 cells overexpressing cyclin D1.	ddr	4-7	cyclin D1	Homo sapiens	165-174
29179029-5	2018	The DDR induced during the S-phase with 3EZ, 20Ac-ingenol treatment was increased by the intra S-phase checkpoint response that was triggered by the loss of nuclear cyclin D1 regulation in BALL-1 cells overexpressing cyclin D1.	ddr	4-7	cyclin D1	Homo sapiens	217-226
29179029-5	2018	The DDR induced during the S-phase with 3EZ, 20Ac-ingenol treatment was increased by the intra S-phase checkpoint response that was triggered by the loss of nuclear cyclin D1 regulation in BALL-1 cells overexpressing cyclin D1.	20ac-ingenol	45-57	cyclin D1	Homo sapiens	165-174
29179029-5	2018	The DDR induced during the S-phase with 3EZ, 20Ac-ingenol treatment was increased by the intra S-phase checkpoint response that was triggered by the loss of nuclear cyclin D1 regulation in BALL-1 cells overexpressing cyclin D1.	20ac-ingenol	45-57	cyclin D1	Homo sapiens	217-226
29179029-6	2018	Although topo 1 catalytic inhibitors induce a decatenation checkpoint and subsequent G2/M phase arrest, the decatenation checkpoint caused by 3EZ, 20Ac-ingenol induced apoptosis only in the BALL-1 cells that accumulated cyclin D1.	20ac-ingenol	147-159	cyclin D1	Homo sapiens	220-229
27995573-6	2018	Forskolin induced hyperphosphorylation of tau and increased cyclin D1 and cyclin B1 protein levels in HEK293/tau441 cells, but not in the HEK293/vector cells, whereas the PKA inhibitor H89 inhibited the effects of forskolin on tau hyperphosphorylation and cyclin D1 and cyclin B1 protein levels.	Colforsin	0-9	cyclin D1	Homo sapiens	60-69
30220832-7	2018	The anti-proliferative action of DPBT in LS180 was attributed to cell cycle arrest in the G1 phase via up-regulation of p27KIP1 and down-regulation of cyclin D1 and CDK4 proteins.	dpbt	33-37	cyclin D1	Homo sapiens	151-160
27995573-6	2018	Forskolin induced hyperphosphorylation of tau and increased cyclin D1 and cyclin B1 protein levels in HEK293/tau441 cells, but not in the HEK293/vector cells, whereas the PKA inhibitor H89 inhibited the effects of forskolin on tau hyperphosphorylation and cyclin D1 and cyclin B1 protein levels.	Colforsin	0-9	cyclin D1	Homo sapiens	256-265
27995573-7	2018	These findings suggest that forskolin induces tau hyperphosphorylation, which is itself necessary for the subsequent increases of cyclin D1 and cyclin B1 levels.	Colforsin	28-37	cyclin D1	Homo sapiens	130-139
28385009-6	2017	Resveratrol lowered cyclin D1 transcription.	Resveratrol	0-11	cyclin D1	Homo sapiens	20-29
29539615-9	2018	In addition, AG1478 reduced the levels of phosphorylated AKT (p-AKT), ERK, p-ERK, cyclin D1, and brain-derived neurotrophic factor (BDNF), while enhancing p53 levels.	RTKI cpd	13-19	cyclin D1	Homo sapiens	82-91
29953997-7	2018	The suppression of STAT3 activation by CDDO-me in W4P-LHB-NIH3T3 cells was further confirmed by decreased cyclin D1 protein levels and increased p21 and p53 mRNA synthesis.	bardoxolone methyl	39-46	cyclin D1	Homo sapiens	106-115
28385009-7	2017	Western blot analysis of the effects of resveratrol on upstream cyclin D1 transcriptional signaling, extracellular signal-related kinase (ERK), p90RSK, Akt, and p70S6K revealed inhibition of Akt but not the ERK signaling pathway.	Resveratrol	40-51	cyclin D1	Homo sapiens	64-73
28385009-8	2017	Collectively, the results indicate that resveratrol inhibits Huh7-HBx proliferation by decreasing cyclin D1 expression through blockade of Akt signaling.	Resveratrol	40-51	cyclin D1	Homo sapiens	98-107
29541385-7	2018	Rb is hyperphosphorylated and inactivated by CDK4/6:cyclin D1 and when restored to its hypophosphorylated active form blocks cell cycle progression.	Rubidium	0-2	cyclin D1	Homo sapiens	52-61
29416786-8	2018	These genes, except PGR and CCND1 which were down-regulated, were also up-regulated in ER+ MCF-7 cells by 4-OH-TAM.	hydroxytamoxifen	106-114	cyclin D1	Homo sapiens	28-33
29267213-3	2017	Our results indicate that PA significantly inhibited cell proliferation, colony formation, migration, invasion, and wound closure of HeLa and SiHa cells, induced cell cycle arrest at G0/G1 phase, upregulated Rb, p16, p21 and p27 proteins and downregulated cyclin D1 and S-phase kinase-associated protein 2 (Skp2) proteins.	praeruptorin A	26-28	cyclin D1	Homo sapiens	256-265
29464035-12	2018	For the decreased cyclin D1 and CDK 4/6 levels found in tumor tissue, these proteins can serve as biomarker for erufosine intervention.	erucylphospho-N,N,N-trimethylpropylammonium	112-121	cyclin D1	Homo sapiens	18-27
29024631-3	2017	In the present study, we have investigated the anticancer effects of luteoloside on non-small cell lung cancer (NSCLC) cells and demonstrated that luteoloside effectively inhibited cancer cell proliferation, inducing G0/G1 phase arrest associated with reduced expression of CyclinE, CyclinD1 and CDK4; we further found that treatment with luteoloside did not strongly result in apoptotic cell death in NSCLC (A549 and H292) cells.	luteolin-7-glucoside	147-158	cyclin D1	Homo sapiens	283-291
29383186-3	2017	Our data showed that BPA induces the down regulation of cyclin D1 expression and the upregulation of the cell cycle inhibitors p21 and p27, leading to cell cycle arrest.	bisphenol A	21-24	cyclin D1	Homo sapiens	56-65
29236027-7	2017	Simvastatin increased the levels of p21cip and p27kip proteins and reduced the levels of hyperphosphorylated-Rb, E2F1 and CCND1 proteins.	Simvastatin	0-11	cyclin D1	Homo sapiens	122-127
29024631-3	2017	In the present study, we have investigated the anticancer effects of luteoloside on non-small cell lung cancer (NSCLC) cells and demonstrated that luteoloside effectively inhibited cancer cell proliferation, inducing G0/G1 phase arrest associated with reduced expression of CyclinE, CyclinD1 and CDK4; we further found that treatment with luteoloside did not strongly result in apoptotic cell death in NSCLC (A549 and H292) cells.	luteolin-7-glucoside	147-158	cyclin D1	Homo sapiens	283-291
28713162-7	2017	We further demonstrated that ABT-263 treatment markedly increased the expression of p21Waf1/Cip1 and decreased the expression of cyclin D1 and phospho-Rb (retinoblastoma tumor suppressor protein) (Ser780) proteins that contributed to the G1/G0-phase arrest.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	29-32	cyclin D1	Homo sapiens	129-138
29238273-8	2017	The inhibitory effect of DMF on cell proliferation was accompanied by the decrease of cyclin D1 and cyclin E1 protein expression, leading to the cell cycle arrest at the G0/G1 phase.	Dimethylformamide	25-28	cyclin D1	Homo sapiens	86-95
29442453-10	2017	CONCLUSIONS: The overall results indicate that CCND1, FOXO1, and JUN may contribute to the induction of resistance to ATO, and that the C-Jun N-terminal kinase (JNK) signaling pathway may have greater significance than the phosphoinositide 3-kinase (PI3K)/Akt pathway in mediating the cytotoxic effects of ATO and the development of resistance to ATO in the HL-60 cell line.	Arsenic Trioxide	118-121	cyclin D1	Homo sapiens	47-52
29049978-6	2017	Mechanistically, ribavirin inhibited eIF4E function in retinoblastoma cells as shown by the decreased protein levels of Cyclin D1, c-Myc and VEGF without affecting their mRNA expression.	Ribavirin	17-26	cyclin D1	Homo sapiens	120-129
28983768-5	2017	In addition, the combination of CBNPs and Pb(AC)2 induced a significant increase in MDA and reduced the activities of ROS, LDH, SOD, and GSH, with G1/S phase arrest via upregulation of Chk1 and downregulation of CDK6 and cyclin D1.	cbnps	32-37	cyclin D1	Homo sapiens	221-230
28983768-5	2017	In addition, the combination of CBNPs and Pb(AC)2 induced a significant increase in MDA and reduced the activities of ROS, LDH, SOD, and GSH, with G1/S phase arrest via upregulation of Chk1 and downregulation of CDK6 and cyclin D1.	pb(ac)2	42-49	cyclin D1	Homo sapiens	221-230
28430389-8	2017	The ROS generated by the combination of carmustine and selenite exhibited a strong inhibition on EGF stimulated EGFR and its downstream signaling molecules such as Akt, NF-kB, ERK1/2, and Cyclin D1.	ros	4-7	cyclin D1	Homo sapiens	188-197
28430389-8	2017	The ROS generated by the combination of carmustine and selenite exhibited a strong inhibition on EGF stimulated EGFR and its downstream signaling molecules such as Akt, NF-kB, ERK1/2, and Cyclin D1.	Carmustine	40-50	cyclin D1	Homo sapiens	188-197
28430389-8	2017	The ROS generated by the combination of carmustine and selenite exhibited a strong inhibition on EGF stimulated EGFR and its downstream signaling molecules such as Akt, NF-kB, ERK1/2, and Cyclin D1.	Selenious Acid	55-63	cyclin D1	Homo sapiens	188-197
29079539-7	2017	Particularly interesting was the downregulation of BCOR, CCND1 and ATR, validated let-7f targets, which play a key role in the mechanisms of neurogenesis, neuroplasticity and protection from oxidative stress in the brain, indicating that escitalopram could exert downstream effects on gene expression through the regulation of specific miRNAs.	Citalopram	238-250	cyclin D1	Homo sapiens	57-62
28990074-8	2017	Furthermore, puerarin increased the protein expression levels of beta-catenin and cyclin D1, which are key factors involved in the Wnt/beta-catenin signaling pathway.	puerarin	13-21	cyclin D1	Homo sapiens	82-91
29423038-6	2018	The superior anti-tumor activity of tubacin was linked to its ability to not only inhibit accumulation of mutant FGFR3, but also to cause robust downregulation of MYC and cyclin D1, and to induce a DNA damage response and apoptosis.	tubacin	36-43	cyclin D1	Homo sapiens	171-180
28644062-0	2017	4-Nerolidylcatechol: apoptosis by mitochondrial mechanisms with reduction in cyclin D1 at G0/G1 stage of the chronic myelogenous K562 cell line.	4-nerolidylcatechol	0-19	cyclin D1	Homo sapiens	77-86
29190771-8	2017	Moreover, the Aza+AA induced prominent expression of GATA 4, alpha-Sarcomeric actinin and phospho beta-catenin while non phospho beta-catenin and Cyclin D1 expression was significantly suppressed as displayed in protein expression analysis.	aza+aa	14-20	cyclin D1	Homo sapiens	146-155
29340064-5	2017	After treatment with resveratrol, the expression of related Wnt/beta-catenin signaling pathway target genes, such as beta-catenin, c-myc, cyclin D1, MMP-2 and MMP-9, was downregulated and an increased E-cadherin level was observed as well.	Resveratrol	21-32	cyclin D1	Homo sapiens	138-147
28855436-7	2017	Forskolin significantly suppressed the growth of all 3 cell lines and also activated the cAMP pathway and inhibited expression of cyclin D1.	Colforsin	0-9	cyclin D1	Homo sapiens	130-139
29070518-8	2017	Digoxin treatment combined with IR allowed the damaged cell to progress through the cell cycle via suppression of cell cycle-related proteins (p53, cyclin D1, cyclin B1, CDK4, and p-cdc2).	Digoxin	0-7	cyclin D1	Homo sapiens	148-157
29172284-5	2017	Consistent with its effect on the cell cycle, aspirin also reduced the expressionof cyclin D1 and cyclin-dependent kinase 4 (Cdk-4), which are important for G0/G1 cell cycle progression.	Aspirin	46-53	cyclin D1	Homo sapiens	84-93
28982980-5	2017	We found that carbofuran increases TGF-beta signaling (i.e. increased phosphorylated SMAD-2/3 and reduced SMAD-7 expression) in the hippocampus, which reduced NSC proliferation because of increased p21 levels and reduced cyclin D1 levels.	Carbofuran	14-24	cyclin D1	Homo sapiens	221-230
29312589-6	2017	G6PD up-regulated ROS generation by facilitating NADPH-dependent NOX4 activation, which led to increased expression of p-STAT3 and CyclinD1.	ros	18-21	cyclin D1	Homo sapiens	131-139
29312589-6	2017	G6PD up-regulated ROS generation by facilitating NADPH-dependent NOX4 activation, which led to increased expression of p-STAT3 and CyclinD1.	NADP	49-54	cyclin D1	Homo sapiens	131-139
29312589-7	2017	Enhanced ROS generation rescued the p-STAT3 and CyclinD1 expression reduction in G6PD-knockdown cells, while ROS scavengers reversed the up-regulated p-STAT3 and CyclinD1 expression in G6PD-overexpressing cells.	ros	9-12	cyclin D1	Homo sapiens	48-56
29218104-6	2017	We further analyzed the expression of cyclins and found that the level of cyclin D1 was significantly reduced after aspirin treatment, while there was no obvious effect on the levels of cyclin A2 and cyclin E1.	Aspirin	116-123	cyclin D1	Homo sapiens	74-83
29218104-10	2017	The results suggested that aspirin inhibited the proliferation of MSCs and caused cell-cycle arrest in the G0/G1 phase through downregulation of cyclin D1, which could be related to the increased expression of miRNA145.	Aspirin	27-34	cyclin D1	Homo sapiens	145-154
28800883-8	2017	In addition, Western blot analysis demonstrated that Jaridon 6 regulated the expression of Wnt pathway proteins, including reduced levels of Dvl 2, survivin and cyclin D1, and increased levels of p-beta-catenin, and AXIN2 in EC109 and EC9706 esophageal cancer cells.	jaridon 6	53-62	cyclin D1	Homo sapiens	161-170
29798594-11	2017	Conclusion: Ursolic acid can effectively inhibit the proliferation of osteosarcoma cell line U2-OS, induce the down-regulation of cyclin D1 expression leading to G 0/G 1 phase arrest, increase the activation of Caspase-3 and promote cell apoptosis.	ursolic acid	12-24	cyclin D1	Homo sapiens	130-139
29296214-10	2017	Notably, PI3K inhibitor LY294002 obviously attenuated the effects of NCOA5 on p-AKT, Cyclin D1, P27 and MMP9.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	cyclin D1	Homo sapiens	85-94
29061795-7	2017	RESULTS: Compared to berberine or evodiamine treatments alone, the combination treatment of berberine (25 muM) and evodiamine (15 muM) synergistically inhibited the proliferation of MCF-7 cells in a time-dependent manner and resulted in the G0/G1 phase accumulation of cells that exhibited increased expression levels of the CDK inhibitors p21 and p27 with a concomitant reduction in the expression levels of cell-cycle checkpoint proteins cyclin D1, cyclin E, CDK4, and CDK6.	Berberine	92-101	cyclin D1	Homo sapiens	440-449
29061795-7	2017	RESULTS: Compared to berberine or evodiamine treatments alone, the combination treatment of berberine (25 muM) and evodiamine (15 muM) synergistically inhibited the proliferation of MCF-7 cells in a time-dependent manner and resulted in the G0/G1 phase accumulation of cells that exhibited increased expression levels of the CDK inhibitors p21 and p27 with a concomitant reduction in the expression levels of cell-cycle checkpoint proteins cyclin D1, cyclin E, CDK4, and CDK6.	evodiamine	115-125	cyclin D1	Homo sapiens	440-449
29061796-5	2017	Pterostilbene induced strong and sustained activation of extracellular signal-regulated kinase (ERK) 1/2, with concomitant cyclin D1 suppression and p21 up-regulation, and inhibited the phosphorylation of AKT and mammalian target of rapamycin (mTOR), followed by subsequent up-regulation of BAX without affecting B-cell lymphoma-extra large (BCL-xL).	pterostilbene	0-13	cyclin D1	Homo sapiens	123-132
29035583-0	2017	Resveratrol Suppresses Growth and Migration of Myelodysplastic Cells by Inhibiting the Expression of Elevated Cyclin D1 (CCND1).	Resveratrol	0-11	cyclin D1	Homo sapiens	110-119
28275859-8	2017	CONCLUSION: Downregulation of miR-138 increases the gene and protein expression of its potential target CCND1 in OLP mucosa which might have a pivotal role in the disease pathogenesis.	mir-138	30-37	cyclin D1	Homo sapiens	104-109
29035583-10	2017	Resveratrol also decreased the expression of CCND1 (a gene that encodes the cyclin D1 protein) and increased expressions of KMT2A [lysine (K)-specific methyltransferase 2A] and caspase-3, suggesting that resveratrol exerts its effect by regulating CCND1 in SKM-1 cells.	Resveratrol	0-11	cyclin D1	Homo sapiens	76-85
29035583-0	2017	Resveratrol Suppresses Growth and Migration of Myelodysplastic Cells by Inhibiting the Expression of Elevated Cyclin D1 (CCND1).	Resveratrol	0-11	cyclin D1	Homo sapiens	121-126
29035583-10	2017	Resveratrol also decreased the expression of CCND1 (a gene that encodes the cyclin D1 protein) and increased expressions of KMT2A [lysine (K)-specific methyltransferase 2A] and caspase-3, suggesting that resveratrol exerts its effect by regulating CCND1 in SKM-1 cells.	Resveratrol	0-11	cyclin D1	Homo sapiens	248-253
29035583-10	2017	Resveratrol also decreased the expression of CCND1 (a gene that encodes the cyclin D1 protein) and increased expressions of KMT2A [lysine (K)-specific methyltransferase 2A] and caspase-3, suggesting that resveratrol exerts its effect by regulating CCND1 in SKM-1 cells.	Resveratrol	0-11	cyclin D1	Homo sapiens	45-50
29035583-12	2017	Our study proved that resveratrol suppresses SKM-1 growth and migration by inhibiting CCND1 expression.	Resveratrol	22-33	cyclin D1	Homo sapiens	86-91
28712859-8	2017	In addition, hydrogen peroxide induced NF-kappaB activation and cell proliferation, along with expression of c-Myc and cyclin D1 in the presence of RhoA WT and RhoA Y42E, but not RhoA Y42F.	Hydrogen Peroxide	13-30	cyclin D1	Homo sapiens	119-128
28598010-11	2017	Therefore, we suggest that through interaction with miR-490-3p, DLEU1 may influence the expression of CDK1, CCND1 and SMARCD1 protein, subsequently promoting the development and progression of EOC.	mir-490-3p	52-62	cyclin D1	Homo sapiens	108-113
29048661-7	2017	The single agent treatment and combinations of 5-FU and Blu9931 arrest cell cycle (P&lt;0.05), increased p27kip1 expression and reduced cyclin D1 expression.	Fluorouracil	47-51	cyclin D1	Homo sapiens	136-145
28849182-8	2017	Chloroquine also disrupted the cell cycle, resulting in the cell cycle arrest of CAL27 and SCC25 cells at G0/G1 phase, via downregulation of cyclin D1.	Chloroquine	0-11	cyclin D1	Homo sapiens	141-150
28280274-0	2017	The CXCR4 inhibitor BL-8040 induces the apoptosis of AML blasts by downregulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression.	4-fluorobenzoyl-TN-14003	20-27	cyclin D1	Homo sapiens	104-113
28882785-9	2017	The expression of cyclin D1 and E was decreased and phosphorylation of CDK1 was increased by orlistat treatment in HSC-3 cells.	Orlistat	93-101	cyclin D1	Homo sapiens	18-27
28882785-10	2017	Thus, orlistat induces apoptosis and cell cycle arrest in G2/M phase in HSC-3 cells through decrease in expression of cyclin D1 and E and increase in phosphorylation of CDK1.	Orlistat	6-14	cyclin D1	Homo sapiens	118-127
28901456-5	2017	In this study, ATO was shown to promote apoptosis and to inhibit cell viability in MCL cell lines, whereas, the expression of DNA methyltransferase-1 (DNMT-1), beta-catenin and the downstream molecules of Wnt/beta-catenin pathway such as c-myc, cyclin D1 and MMP7 were all decreased in a dose-dependent manner with ATO.	ato	15-18	cyclin D1	Homo sapiens	245-254
29098029-7	2017	The results revealed that 5F and cisplatin synergistically induced apoptosis and inhibited cell growth, arrested cell cycles in the G0/G1 phase, downregulated beta-catenin, c-Myc and cyclin D1, and upregulated GSK-3beta.	Cisplatin	33-42	cyclin D1	Homo sapiens	183-192
29094813-9	2017	P21 was up-regulated and cyclin D1 was down-regulated at both mRNA and protein levels under sodium valproate (2.0 mmol/L, 48h)(P&lt;0.05), although cyclin E and cyclin A remained changed.	Valproic Acid	92-108	cyclin D1	Homo sapiens	25-34
29113274-10	2017	Additionally, simvastatin in combination with doxorubicin significantly induced expression of the cyclin-dependent kinase inhibitor p21, increased cytochrome c and caspase 3 expression and reduced cyclin D1 expression.	Simvastatin	14-25	cyclin D1	Homo sapiens	197-206
29113274-10	2017	Additionally, simvastatin in combination with doxorubicin significantly induced expression of the cyclin-dependent kinase inhibitor p21, increased cytochrome c and caspase 3 expression and reduced cyclin D1 expression.	Doxorubicin	46-57	cyclin D1	Homo sapiens	197-206
29059232-6	2017	We found that ATO treatment of HeLa cells resulted in significant decreases in the expression of beta-catenin mRNA and protein and the downstream target factors c-Myc, cyclin B1, and cyclin D1 in the Wnt signaling pathway.	Arsenic Trioxide	14-17	cyclin D1	Homo sapiens	183-192
29285232-4	2017	In addition, lonafarnib caused G1 to S phase arrest through the downregulation of Cyclin D1, CDK6 and SKP2, while it induced cellular apoptosis by promoting the cleavage and activation of Caspase-3 and PARP.	lonafarnib	13-23	cyclin D1	Homo sapiens	82-91
29123981-8	2017	Expression of cyclin D1, PDGFR, Notch1, and Hes1 was markedly enhanced by PDGF-BB but inhibited by DAPT.	dapt	99-103	cyclin D1	Homo sapiens	14-23
29039762-8	2017	They inhibited cyclin D1 phosphorylation on a DYRK1A phosphosite in cultured cells.	phosphosite	53-64	cyclin D1	Homo sapiens	15-24
28666623-3	2017	CG902 specifically inhibited STAT3 phosphorylation at Tyr-705 in DU145 prostate cancer cells and decreased the expression levels of STAT3 target genes, such as cyclin D1, cyclin A, and survivin.	cg902	0-5	cyclin D1	Homo sapiens	160-169
28978936-6	2017	Interestingly, co-incubation FLSs with Pioditazone (25 muM) and over expression vector with pEGFP-N1-PPAR-gamma reduced proliferation and expressions of c-Myc, Cyclin D1, MMP-1, and MMP-9 in AA FLSs, besides TIMP-1.	pioditazone	39-50	cyclin D1	Homo sapiens	160-169
28843521-4	2017	The expression levels of cell cycle proteins (Ccnd1 and Cdk4) and stem cell markers (Oct4, CD44, and CD133) were decreased in curcumin-treated HuPCaSCs.	Curcumin	126-134	cyclin D1	Homo sapiens	46-51
28968471-5	2017	Our results showed that siHuR decreased transcriptional expressions of galectin-3, beta-catenin, cyclin D1, Bcl-2, P-gp, MRP1, and MRP2 in epirubicin-treated colon cancer cells.	Epirubicin	139-149	cyclin D1	Homo sapiens	97-106
28374108-5	2017	We found that geraniin treatment for 48 h significantly (P &lt; 0.05) impaired the phosphorylation of STAT3 and reduced the expression of downstream target genes Bcl-xL, Mcl-1, Bcl-2, and cyclin D1.	Geraniin	14-22	cyclin D1	Homo sapiens	188-197
28981601-6	2017	The results revealed that pyrvinium pamoate treatment repressed the phosphorylation of GSK3beta at S9 which might be mediated by AKT, and decreased the protein levels of beta-catenin and its downstream targets (c-Myc, cyclin D1).	pyrvinium	26-43	cyclin D1	Homo sapiens	218-227
28779709-7	2017	TREATMENT: with magnolol induced cell cycle arrest in G1 phase with a downregulation of cell cycle protein CyclinD1 (all P&lt;0.05).	magnolol	16-24	cyclin D1	Homo sapiens	107-115
28374108-8	2017	Overexpression of constitutively active STAT3 significantly (P &lt; 0.05) reversed geraniin-mediated growth suppression and apoptosis, which was accompanied by restoration of Bcl-xL, Mcl-1, Bcl-2, and cyclin D1 expression.	Geraniin	83-91	cyclin D1	Homo sapiens	201-210
28849149-11	2017	ERK inhibitor PD98059 partially inhibited the role of Rab5a on MMP-2, cyclin D1, cell proliferation and invasion.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	14-21	cyclin D1	Homo sapiens	70-79
28912852-9	2017	Baicalein-treated cells also exhibited significantly reduced expression of Bcl-2, PCNA and cyclin D1 compared with control cells (P&lt;0.05).	baicalein	0-9	cyclin D1	Homo sapiens	91-100
28849003-8	2017	In addition, the cell cycle-related proteins, including p27, CHK1, cyclin D1, CDK1, p-AMP-activated protein kinase (AMPK) and p-protein kinase B (AKT), were regulated by chrysophanol nanoparticles to prevent human prostate cancer cell progression.	chrysophanic acid	170-182	cyclin D1	Homo sapiens	67-76
28719035-5	2017	Accordingly, melatonin down-regulated gene expression of cyclin D1, PCNA, matrix metallopeptidase-3, and matrix metallopeptidase-9 and upregulated gene expression of collagen type II alpha 1 chain and aggrecan in NP cells.	Melatonin	13-22	cyclin D1	Homo sapiens	57-66
28849226-7	2017	Cell cycle was arrested at G1 phase and expression of cyclin D1, c-myc, PCNA was reduced while p21 was upregulated during daidzein treatment.	daidzein	122-130	cyclin D1	Homo sapiens	54-63
28849118-6	2017	Western blotting demonstrated K-Ras-p110alpha interaction was required for the effects of aspirin-induced inhibition on cell growth and cell cycle transition via cell cycle regulators, including cyclin D1 and cyclin-dependent kinase 2 (CDK2).	Aspirin	90-97	cyclin D1	Homo sapiens	195-204
28891417-12	2017	Although estradiol induced both cyclin D1 and cyclin D2 mRNA, DHT did not induce these markers of cell proliferation.	Estradiol	9-18	cyclin D1	Homo sapiens	32-41
28943959-3	2017	In the present study, the expression of the cyclin D1 (CCND1), cyclin D2 (CCND2) and cyclin D3 (CCND3) genes in gastric cancer patients was explored using the Oncomine database, and their correlation with overall survival (OS) and progression-free survival (PFS) was evaluated using Kaplan-Meier analysis.	oncomine	159-167	cyclin D1	Homo sapiens	44-53
28688761-6	2017	Overexpression of Gm4419 in injury-treated astrocytes increased protein expressions of TNF-alpha, Bax, cleaved caspase-3 and cleaved caspase-9, decreased levels of Bcl-2 and CyclinD1, and significantly led to cellular apoptosis.	gm4419	18-24	cyclin D1	Homo sapiens	174-182
28774850-0	2017	[Ru(pipe)(dppb)(bipy)]PF6: A novel ruthenium complex that effectively inhibits ERK activation and cyclin D1 expression in A549 cells.	Ruthenium complex	35-52	cyclin D1	Homo sapiens	98-107
29262559-5	2017	Cyclin d1 and DICER 1 were proved to promote Let-7 maturation, and in present study, we proved that miR-129 exhibited inhibition on ESR1 and halted the cyclin d1/DICER 1 sustaining of Let-7, which consequently released the Let-7 degradation of NUMB.	mir-129	100-107	cyclin D1	Homo sapiens	0-9
29262559-5	2017	Cyclin d1 and DICER 1 were proved to promote Let-7 maturation, and in present study, we proved that miR-129 exhibited inhibition on ESR1 and halted the cyclin d1/DICER 1 sustaining of Let-7, which consequently released the Let-7 degradation of NUMB.	mir-129	100-107	cyclin D1	Homo sapiens	152-161
29262559-7	2017	In conclusion, we demonstrated the negative regulation of miR-129 on NOTCH signaling activation in BrCSCs" renewal, which was achieved via continuous suppression on cyclin d1/DICER1 sustaining of Let-7 level, and eventually rescued the targeted inhibition of NUMB.	mir-129	58-65	cyclin D1	Homo sapiens	165-174
28910957-10	2017	Among them, the effect of NAC in patients with two or more genes copy number variations of c-Myc, CCND1, p53, p16 were poorer than that in patients with one or not gene copy number variations (P=0.000).	nac	26-29	cyclin D1	Homo sapiens	98-103
29156780-6	2017	Moreover, the level of beta-catenin and its target genes, including c-myc, cyclinD1, and survivin significantly decreased in baicalein-treated osteosarcoma cells, whereas exogenous expression of beta-catenin could reverse the anti-proliferative and anti-metastatic effects of baicalein.	baicalein	125-134	cyclin D1	Homo sapiens	75-83
28634044-0	2017	miR-218 suppresses gastric cancer cell cycle progression through the CDK6/Cyclin D1/E2F1 axis in a feedback loop.	mir-218	0-7	cyclin D1	Homo sapiens	74-83
28634044-5	2017	Overexpression of CDK6 and Cyclin D1 reversed miR-218-mediated inhibition of pRB/E2F1 signaling and attenuated the miR-218-induced cell cycle arrest.	mir-218	46-53	cyclin D1	Homo sapiens	27-36
28634044-5	2017	Overexpression of CDK6 and Cyclin D1 reversed miR-218-mediated inhibition of pRB/E2F1 signaling and attenuated the miR-218-induced cell cycle arrest.	mir-218	115-122	cyclin D1	Homo sapiens	27-36
28910957-12	2017	Conclusion: These results indicated that the copy number variations of c-Myc, CCND1, p53, and p16 in patients were significant correlation with poor effect of NAC.	nac	159-162	cyclin D1	Homo sapiens	78-83
28870200-12	2017	CONCLUSIONS: Our results suggest that DKC-E70 may downregulate cyclin D1 as one of the potential anti-cancer targets through cyclin D1 degradation by T286 phosphorylation dependent on ERK1/2, p38 or GSK3beta, and cyclin D1 transcriptional inhibition through Wnt signaling.	C.I. Basic Blue 54	150-154	cyclin D1	Homo sapiens	125-134
28878842-8	2017	GSK-343-treated cells displayed moderate expressional changes, with CCND1 increased in HPV-positive cell lines and decreased TP53 in HPV-negative SCC-1.	gsk	0-3	cyclin D1	Homo sapiens	68-73
28870200-8	2017	In cyclin D1 degradation, we found that cyclin D1 downregulation by DKC-E70 was attenuated in presence of MG132.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	106-111	cyclin D1	Homo sapiens	3-12
28870200-8	2017	In cyclin D1 degradation, we found that cyclin D1 downregulation by DKC-E70 was attenuated in presence of MG132.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	106-111	cyclin D1	Homo sapiens	40-49
28870200-9	2017	In addition, DKC-E70 phosphorylated threonine-286 (T286) of cyclin D1 and T286A abolished cyclin D1 downregulation by DKC-E70.	Threonine	36-45	cyclin D1	Homo sapiens	60-69
28870200-9	2017	In addition, DKC-E70 phosphorylated threonine-286 (T286) of cyclin D1 and T286A abolished cyclin D1 downregulation by DKC-E70.	Threonine	36-45	cyclin D1	Homo sapiens	90-99
28870200-12	2017	CONCLUSIONS: Our results suggest that DKC-E70 may downregulate cyclin D1 as one of the potential anti-cancer targets through cyclin D1 degradation by T286 phosphorylation dependent on ERK1/2, p38 or GSK3beta, and cyclin D1 transcriptional inhibition through Wnt signaling.	C.I. Basic Blue 54	150-154	cyclin D1	Homo sapiens	63-72
28870200-12	2017	CONCLUSIONS: Our results suggest that DKC-E70 may downregulate cyclin D1 as one of the potential anti-cancer targets through cyclin D1 degradation by T286 phosphorylation dependent on ERK1/2, p38 or GSK3beta, and cyclin D1 transcriptional inhibition through Wnt signaling.	C.I. Basic Blue 54	150-154	cyclin D1	Homo sapiens	125-134
28643892-4	2017	From a mechanistic standpoint, calcitriol induced endoplasmic reticulum (ER) stress, which was potentially responsible for downregulation of cyclin D1, activation of p38 MAPK, and intracellular production of reactive oxygen species (ROS).	Calcitriol	31-41	cyclin D1	Homo sapiens	141-150
28444938-4	2017	mRNA and protein expressions of proliferation factors, such as cyclin D1, COX-2, and proliferating cell nuclear antigen (PCNA), increased in chronically exposed arsenite SV-HUC-1 cells with exposure time.	arsenite	161-169	cyclin D1	Homo sapiens	63-72
28444938-6	2017	Knockdown of STAT3 reduced expressions of cyclin D1, COX-2, PCNA, and BCL2 induced by arsenite.	arsenite	86-94	cyclin D1	Homo sapiens	42-51
28444938-7	2017	In conclusion, arsenic induced proliferation in human uroepithelial cells after short and long term exposure to arsenite and JAK2/STAT3 signaling pathway might be pivotal in arsenite-induced proliferation by regulating cyclin D1, COX-2, PCNA, and BCL2.	Arsenic	15-22	cyclin D1	Homo sapiens	219-228
28444938-7	2017	In conclusion, arsenic induced proliferation in human uroepithelial cells after short and long term exposure to arsenite and JAK2/STAT3 signaling pathway might be pivotal in arsenite-induced proliferation by regulating cyclin D1, COX-2, PCNA, and BCL2.	arsenite	174-182	cyclin D1	Homo sapiens	219-228
31966836-0	2017	Luteolin suppresses tumor progression through lncRNA BANCR and its downstream TSHR/CCND1 signaling in thyroid carcinoma.	Luteolin	0-8	cyclin D1	Homo sapiens	83-88
28578456-6	2017	Sequential combination of docetaxel and SC-43 in vitro showed enhanced anti-proliferation and apoptosis associated with decreased p-STAT3 and decreased STAT3-downstream effector cyclin D1 in the TNBC cell lines MDA-MB-231, MDA-MB-468, and HCC-1937.	Docetaxel	26-35	cyclin D1	Homo sapiens	178-187
28578456-6	2017	Sequential combination of docetaxel and SC-43 in vitro showed enhanced anti-proliferation and apoptosis associated with decreased p-STAT3 and decreased STAT3-downstream effector cyclin D1 in the TNBC cell lines MDA-MB-231, MDA-MB-468, and HCC-1937.	SC-43	40-45	cyclin D1	Homo sapiens	178-187
28500231-4	2017	Inhibiting PP2A and beta-catenin interaction by selectively engaging PR55alpha-binding site, our most potent small-molecule inhibitor diminished the expression of active beta-catenin and its target proteins c-Myc and Cyclin D1.	pr55alpha	69-78	cyclin D1	Homo sapiens	217-226
28714004-9	2017	In addition, treatment with the TAK1 selective inhibitor OZ reduced the proliferation and invasion abilities of MGC803 cells and significantly reduced the expression levels of phosphorylated-TAK1 (Thr187), nuclear p65, cyclin D1, Bcl-2 apoptosis regulator and matrix metallopeptidase (MMP)9 (P&lt;0.05).	5-7-oxo-zeaenol	57-59	cyclin D1	Homo sapiens	219-228
28703366-4	2017	Also, the combination of TAB induced G1 -phase cell-cycle arrest by downregulating the level of cyclin D1, cyclin E, and CDC2.	tab	25-28	cyclin D1	Homo sapiens	96-105
29089081-8	2017	Verteporfin inhibited significantly the expressions of c-MYC, cyclin D1, YAP, CYR61 and CTGF.	Verteporfin	0-11	cyclin D1	Homo sapiens	62-71
30090552-5	2017	Furthermore, TBP and TBEP caused a concentration-dependent decrease of cyclin D1 expression and an increase of cyclin-dependent kinase (CDK) inhibitor proteins such as p21 and p27, resulting in significant cell cycle arrest in the G0/G1 phase.	tributyl phosphate	13-16	cyclin D1	Homo sapiens	71-80
30090552-5	2017	Furthermore, TBP and TBEP caused a concentration-dependent decrease of cyclin D1 expression and an increase of cyclin-dependent kinase (CDK) inhibitor proteins such as p21 and p27, resulting in significant cell cycle arrest in the G0/G1 phase.	tris(2-butoxyethyl) phosphate	21-25	cyclin D1	Homo sapiens	71-80
28655771-9	2017	These findings suggest that p115 RhoGEF is critical for MCP1-induced HASMC migration and proliferation in vitro and for injury-induced neointima formation in vivo by modulating Rac1-NFATc1-cyclin D1-CDK6-PKN1-CDK4-PAK1 signaling.	hasmc	69-74	cyclin D1	Homo sapiens	189-198
28829835-5	2017	We furthermore show that vemurafenib and trametinib abrogated the activity of ERK1/2, arrested cells in G0/G1 cell cycle phase, triggered apoptosis, induced changes in the expression of CXCL8, CCND1 and CTGF and the frequency of Ki-67high and CD271high cells.	Vemurafenib	25-36	cyclin D1	Homo sapiens	193-198
28829835-5	2017	We furthermore show that vemurafenib and trametinib abrogated the activity of ERK1/2, arrested cells in G0/G1 cell cycle phase, triggered apoptosis, induced changes in the expression of CXCL8, CCND1 and CTGF and the frequency of Ki-67high and CD271high cells.	trametinib	41-51	cyclin D1	Homo sapiens	193-198
29069825-5	2017	Using a point-mutant lentivirus transfection and using an activator of P300 allowed us to observe the mono-ADP-ribosylation at H3R117 and enhancement of the activity of P300 to up-regulate the level of acetylated beta-catenin, which could increase the expression of c-myc and cyclin D1.	mono-adp	102-110	cyclin D1	Homo sapiens	276-285
28861154-7	2017	STAT3 pathway was involved in curcumin-induced tumor inhibition, in which phosphorylation of STAT3 and JAK in ectopic xenograft were both declined after curcumin treatment, and the STAT3-regulated promoter activation of VEGF, Bcl-xL, Cyclin D1 was also significantly reduced after treatment.	Curcumin	30-38	cyclin D1	Homo sapiens	234-243
28861154-7	2017	STAT3 pathway was involved in curcumin-induced tumor inhibition, in which phosphorylation of STAT3 and JAK in ectopic xenograft were both declined after curcumin treatment, and the STAT3-regulated promoter activation of VEGF, Bcl-xL, Cyclin D1 was also significantly reduced after treatment.	Curcumin	153-161	cyclin D1	Homo sapiens	234-243
28810862-8	2017	Furthermore, we found that EGCG reduced the protein levels of cyclin D1 and Zac1 (a zinc-finger protein which regulates apoptosis and cell cycle arrest 1) dose-dependently in proliferative as compared to differentiated keratinocytes.	epigallocatechin gallate	27-31	cyclin D1	Homo sapiens	62-71
28811522-4	2017	Atranorin suppressed beta-catenin-mediated TOPFLASH activity by inhibiting the nuclear import of beta-catenin and downregulating beta-catenin/LEF and c-jun/AP-1 downstream target genes such as CD44, cyclin-D1 and c-myc.	atranorin	0-9	cyclin D1	Homo sapiens	199-208
28673967-3	2017	Piperlongumine also downregulated expression of Sp1, Sp3, Sp4, and several pro-oncogenic Sp-regulated genes, including cyclin D1, survivin, cMyc, EGFR and hepatocyte growth factor receptor (cMet), and these responses were also attenuated after cotreatment with glutathione.	piperlonguminine	0-14	cyclin D1	Homo sapiens	119-128
28370734-11	2017	Adenosine induced G1 cell cycle arrest in breast CSCs in conjunction with a marked down-regulation of cyclin D1 and CDK4.	Adenosine	0-9	cyclin D1	Homo sapiens	102-111
28555524-8	2017	Mechanistically, ellipticine reduced the phosphorylation of STAT3 and downregulated the expression of Mcl-1, cyclin D1 and Bcl-2.	ellipticine	17-28	cyclin D1	Homo sapiens	109-118
28479391-4	2017	Activation of caspase-3, increased level of cytosolic cytochrome c, decreased levels of pAkt, pGSK-3beta and cyclin D1 in 40 muM Quercetin treated HT29 cells alone.	Quercetin	129-138	cyclin D1	Homo sapiens	109-118
28586029-11	2017	Moreover, fangchinoline-treated MG63 cells showed downregulated expression of cyclin D1 and matrix metalloproteinase 2 and 9, which act downstream of PI3K, and upregulated expression of caspase-3 and caspase-8.	fangchinoline	10-23	cyclin D1	Homo sapiens	78-87
28176351-8	2017	Knockdown of Cx43 using siRNA blocked Cd-induced proliferation and interfered with the Cd-induced changes in the protein levels of cyclin D1, cyclin B1, p27Kip1 (p27) and p21Waf1/Cip1 (p21).	Cadmium	87-89	cyclin D1	Homo sapiens	131-140
28555524-10	2017	Overexpression of constitutively active STAT3 reversed the suppressive effects of ellipticine on RA-FLSs, which was accompanied by restoration of Mcl-1, cyclin D1 and Bcl-2.	ellipticine	82-93	cyclin D1	Homo sapiens	153-162
28627625-0	2017	Effects of metal ions on the structure and activity of a human anti-cyclin D1 single-chain variable fragment AD5.	Metals	11-16	cyclin D1	Homo sapiens	68-77
31966695-5	2017	Pretreatment with AUDA (0.5-8 microM) dose-dependently inhibited TNF-alpha-induced proliferation of HASMCs as revealed by the MTT assay and the decreased expression of Cyclin D1 and beta-tubulin.	12-(3-adamantan-1-ylureido)dodecanoic acid	18-22	cyclin D1	Homo sapiens	168-177
28656255-7	2017	miR-320b mimic impaired cell cycle and metastasis through inhibiting the expression of G1/S transition key regulator Cyclin D1 as well as decreasing the expression level of MMP2 and MMP9.	mir-320b	0-8	cyclin D1	Homo sapiens	117-126
28631436-12	2017	Mechanistic studies revealed that BL140 blocked G1 phase cell cycle entry by reducing cyclin D1 but increasing p27kip1 protein levels.	bl140	34-39	cyclin D1	Homo sapiens	86-95
28781641-8	2017	Therefore, the present results indicated that the anticancer effects of liriodenine suppress cell growth and induce the apoptosis of human breast cancer MCF-7 cells through inhibition of Bcl-2, cyclin D1 and VEGF expression, and upregulation of p53 expression.	liriodenine	72-83	cyclin D1	Homo sapiens	194-203
28789402-4	2017	Treatment of SMMC-7721 cells with esculetin resulted in downregulation of the mRNA and protein levels of beta-catenin, c-Myc and cyclin D1.	esculetin	34-43	cyclin D1	Homo sapiens	129-138
29050266-6	2017	The IL-6-stimulated activation of STAT3 and its downstream genes Cyclin D1, survivin, and Bcl-xL was also repressed by Physapubescin B.	physapubescin B	119-134	cyclin D1	Homo sapiens	65-74
28823263-7	2017	Moreover, phosphorylation of GSF-3beta, beta-catenin, c-myc and cyclinD1 decreased after exposure to phenelzine for 24 hours.	Phenelzine	101-111	cyclin D1	Homo sapiens	64-72
28823273-6	2017	In addition, DATS treatment could significantly induce the G1/S arrest and suppress the expression of cyclin D1, cyclin E, CDK2 and CDK4.	allicin	13-17	cyclin D1	Homo sapiens	102-111
28823273-7	2017	CONCLUSION: DATS can inhibit the proliferation and colony-forming of SP cells in multiple myeloma, and induce the G1/S arrest that may be carried out via suppressing the expression of cyclin D1, cyclin E, CDK2 and CDK4.	allicin	12-16	cyclin D1	Homo sapiens	184-193
28733577-6	2017	In particular, NTP treatment immediately dispersed E-cadherin-mediated cell-to-cell interactions, resulting in the translocation of beta-catenin to the nucleus and leading to the enhanced transcription of target genes including c-MYC and cyclin D1.	ntp	15-18	cyclin D1	Homo sapiens	238-247
28969056-8	2017	The miR-708 inhibitor or 5-aza significantly increased DKK3 expression and decreased p-GSK3beta, cyclin D1 and nuclear and cytoplasmic beta-catenin protein expression, indicating that the Wnt/beta-catenin signaling pathway was inhibited.	Azacitidine	25-30	cyclin D1	Homo sapiens	97-106
28720098-0	2017	Arcyriaflavin a, a cyclin D1-cyclin-dependent kinase4 inhibitor, induces apoptosis and inhibits proliferation of human endometriotic stromal cells: a potential therapeutic agent in endometriosis.	arcyriaflavin A	0-15	cyclin D1	Homo sapiens	19-28
28720098-3	2017	This study aimed to determine whether arcyriaflavin A, a representative inhibitor of cyclin D1-cyclin-dependent kinase 4 (CDK4), is beneficial in the treatment of endometriosis.	arcyriaflavin A	38-53	cyclin D1	Homo sapiens	85-94
28247504-7	2017	Co-treated cells had greater reductions in gefitinib-induced CYP1A1/CYB1B1, EGFR, cyclin D1, p-Akt (Ser473), and survivin mRNA/protein expression, as well as an increase in p-p53 (Ser15).	Gefitinib	43-52	cyclin D1	Homo sapiens	82-91
28716056-8	2017	Cell cycle of ISL treated HASMCs arrested mainly in G1/S phase and accompanied with elevated expression of p27 and decreased expression of CyclinD1 and CyclinE.	hasmcs	26-32	cyclin D1	Homo sapiens	139-147
28696369-4	2017	It was discovered that DHAP downregulated the expression of oncogenic gene products like Bcl-xl, Bcl-2, Mcl-1, Survivin, Cyclin D1, IAP-1, Cyclin E, COX-2, and MMP-9, and upregulated the expression of Bax and p21 proteins, consistent with the induction of G2/M phase cell cycle arrest and apoptosis in U266 cells.	Dihydroxyacetone Phosphate	23-27	cyclin D1	Homo sapiens	121-130
28591705-5	2017	Chaperone-mediated autophagy induced tolerance to oxaliplatin treatment by reducing cyclin D1 expression; thus, cyclin D1 overexpression stimulated oxaliplatin-induced apoptosis.	Oxaliplatin	50-61	cyclin D1	Homo sapiens	84-93
28245170-10	2017	CFEZO treatments induced upregulation of p53 and p21 expression and downregulation of cyclin D1 and cyclin-dependent kinase-4 expression, which were accompanied by G2/M phase arrest.	cfezo	0-5	cyclin D1	Homo sapiens	86-95
28591705-5	2017	Chaperone-mediated autophagy induced tolerance to oxaliplatin treatment by reducing cyclin D1 expression; thus, cyclin D1 overexpression stimulated oxaliplatin-induced apoptosis.	Oxaliplatin	148-159	cyclin D1	Homo sapiens	112-121
28318508-6	2017	TBMEHP induced a marked G0/G1 cell cycle arrest and robust cell apoptosis at 1mug/mL by inducing expression of p53, GADD45alpha and cyclin dependent kinase (CDK) inhibitors (p21and p27) while suppressing the expression of cyclin D1, CDK2, CDK6, and Bcl-2.	tbmehp	0-6	cyclin D1	Homo sapiens	222-231
28474758-5	2017	ATP could promote the in vitro invasion of breast cancer cells and enhance the expression of beta-catenin as well as its downstream target genes CD44, c-Myc and cyclin D1, while P2Y2 knockdown attenuated above ATP-driven events in vitro and in vivo.	Adenosine Triphosphate	0-3	cyclin D1	Homo sapiens	161-170
28529129-7	2017	We also found that icaritin inhibited ER-alpha36-mediated MAPK/ERK pathway and cyclin D1 induction by estrogen.	icaritin	19-27	cyclin D1	Homo sapiens	79-88
28952212-17	2017	The 5-year OS was 55% in the group with a CycD1 expression below 11.5, while it was 79% in the group above the 11.5 value (p=0.044).	Osmium	11-13	cyclin D1	Homo sapiens	42-47
28643150-8	2017	Treatment with demethylating agent (5-aza-2"-deoxycytidine) or exogenous expression of Six3 restored Six3 production and resulted in suppression of cell cycle G1/S transition, proliferation and invasion and down-regulation of the expression of Wnt1, p-GSK3-beta, beta-catenin and cyclin D1 in glioma U251 cells.	Decitabine	36-58	cyclin D1	Homo sapiens	280-289
28535012-8	2017	Western blot analysis revealed that neokestose treatment reduced the expression levels of p-IkappaB and cyclin D1.	neokestose	36-46	cyclin D1	Homo sapiens	104-113
28084852-8	2017	Besides, digoxin inhibited NF-kappaB and TNF-alpha-stimulated NF-kappaB activity, and suppressed NF-kappaB initiating genes (Bcl-2, Bcl-xL, cyclin D1, and c-myc), however, increased p21cip1.	Digoxin	9-16	cyclin D1	Homo sapiens	140-149
28586058-0	2017	3,3"-diindolylmethane downregulates cyclin D1 through triggering endoplasmic reticulum stress in colorectal cancer cells.	3,3'-diindolylmethane	0-21	cyclin D1	Homo sapiens	36-45
28693280-4	2017	The results indicated that rapamycin alone decreased the phosphorylation of S6 and GSK3beta, as well as the expression of cyclin D1, in NPC cells.	Sirolimus	27-36	cyclin D1	Homo sapiens	122-131
28693189-10	2017	EGCG decreased MDA-MB-231 cell viability and significantly downregulated the expression of beta-catenin, phosphorylated Akt and cyclin D1.	epigallocatechin gallate	0-4	cyclin D1	Homo sapiens	128-137
28693280-7	2017	In conclusion, rapamycin improves the anti-tumor effect of IR for treating NPC through inhibiting the Akt/mechanistic target of rapamycin/S6 and Akt/GSK3beta/cyclin D1 signaling pathways.	Sirolimus	15-24	cyclin D1	Homo sapiens	158-167
28481876-7	2017	The cyclin D1/MCM8 interaction is required for Rb phosphorylation and S-phase entry in cancer cells.	Rubidium	47-49	cyclin D1	Homo sapiens	4-13
28120452-8	2017	Further, silibinin treatment decreased the phosphorylated Akt (Serine 473), phosphorylated ERK1/2 (Threonine 202/Tyrosine 204), cyclin D1 and Gli-1 level but increased the SUFU expression in ASZ001-Sant-1-resistant cells.	Silybin	9-18	cyclin D1	Homo sapiens	128-137
27879454-2	2017	As previously shown, in human endometrial cells, androstenediol increases CYCLIN D1 levels and KI67 and decreases P27 content.	Androstenediol	49-63	cyclin D1	Homo sapiens	74-83
27879454-5	2017	The data showed that androstenediol treatment significantly increases CYCLIN D1 and decreases P27 levels through ERalpha activation ( P &lt; .05).	Androstenediol	21-35	cyclin D1	Homo sapiens	70-79
28744352-7	2017	Moreover, HeLa cells were treated with the CYP1B1 inducer 7,12-dimethylbenz[alpha]anthracene (DMBA) or the CYP1B1 specific inhibitor, tetramethoxystilbene (TMS) and consequently DMBA increased and TMS decreased beta-catenin and cyclin D1 expression, respectively.	7,12-dimethylbenz[alpha]anthracene	58-92	cyclin D1	Homo sapiens	228-237
28670365-5	2017	LC-0882 was found to significantly inhibit the proliferation of human gastric cancer cells by repressing phospho-PAK4/cyclin D1 and CDK4/6 expression.	lc-0882	0-7	cyclin D1	Homo sapiens	118-127
28569510-2	2017	Herein, an ultrasensitive ECL biosensor for the detection of Cyclin-D1 (CCND1) was designed by utilizing in situ electrogenerated silver nanoclusters (AgNCs) as ECL emitters and Fe3O4-CeO2 nanocomposites as a coreaction accelerator.	ferryl iron	178-183	cyclin D1	Homo sapiens	61-70
28569510-2	2017	Herein, an ultrasensitive ECL biosensor for the detection of Cyclin-D1 (CCND1) was designed by utilizing in situ electrogenerated silver nanoclusters (AgNCs) as ECL emitters and Fe3O4-CeO2 nanocomposites as a coreaction accelerator.	ferryl iron	178-183	cyclin D1	Homo sapiens	72-77
28569510-2	2017	Herein, an ultrasensitive ECL biosensor for the detection of Cyclin-D1 (CCND1) was designed by utilizing in situ electrogenerated silver nanoclusters (AgNCs) as ECL emitters and Fe3O4-CeO2 nanocomposites as a coreaction accelerator.	ceric oxide	184-188	cyclin D1	Homo sapiens	61-70
28569510-2	2017	Herein, an ultrasensitive ECL biosensor for the detection of Cyclin-D1 (CCND1) was designed by utilizing in situ electrogenerated silver nanoclusters (AgNCs) as ECL emitters and Fe3O4-CeO2 nanocomposites as a coreaction accelerator.	ceric oxide	184-188	cyclin D1	Homo sapiens	72-77
28694919-11	2017	8-pCPT-cGMP also increased activation of cAMP response element-binding protein (CREB) and expression of cyclins D1 and E in FPG.	8-((4-chlorophenyl)thio)cyclic-3',5'-GMP	0-11	cyclin D1	Homo sapiens	104-120
28670110-10	2017	CTS treatment induced S-phase arrest with a decrease of cyclin A1 and an increase of cyclin D1 protein level.	cryptotanshinone	0-3	cyclin D1	Homo sapiens	85-94
28551632-0	2017	The Prognostic Value of the Immunohistochemical Expression of Phosphorylated RB and p16 Proteins in Association with Cyclin D1 and the p53 Pathway in a Large Cohort of Patients with Breast Cancer Treated with Taxane-based Adjuvant Chemotherapy.	taxane	209-215	cyclin D1	Homo sapiens	117-126
28740556-5	2017	YD277 also reduced the protein expression levels of Cyclin D1, Bcl2 and Bclxl and promoted the expression of p21 and p27.	yd277	0-5	cyclin D1	Homo sapiens	52-61
28222387-10	2017	Moreover, baicalein strongly activated the Wnt/beta-catenin pathway and up-regulated the expression of beta-catenin, lymphoid enhancer factor 1 (LEF1) and Cyclin D1.	baicalein	10-19	cyclin D1	Homo sapiens	155-164
28542559-8	2017	Moreover, fluvastatin suppressed the protein expressions of cyclin D1 and Cdk4, but induced p27, and blocked VSMC proliferation by regulating cell cycle.	Fluvastatin	10-21	cyclin D1	Homo sapiens	60-69
28440424-6	2017	Importantly, metformin reduced the expression of cyclin D1, cyclin E, cyclin-dependent kinase 4, and phosphorylated retinoblastoma protein, which resulted in cell cycle arrest at the G0/G1 phase.	Metformin	13-22	cyclin D1	Homo sapiens	49-58
27918099-0	2017	MiR-193b Mediates CEBPD-Induced Cisplatin Sensitization Through Targeting ETS1 and Cyclin D1 in Human Urothelial Carcinoma Cells.	Cisplatin	32-41	cyclin D1	Homo sapiens	83-92
27918099-11	2017	CDDP-induced CEBPD trans-activated miR-193b-3p expression and it directly targeted the 3"-UTR of Cyclin D1 and ETS1 mRNA, and silenced the protein expression.	Cisplatin	0-4	cyclin D1	Homo sapiens	97-106
28537766-6	2017	RESULTS: Under proliferative conditions, pirfenidone inhibited Tenon"s fibroblasts proliferation and arrested the cell cycle at the G1 phase; decreased the phosphorylation of AKT, GSK3beta, ERK1/2/MAPK, and JNK/MAPK; increased the phosphorylation of p38 MAPK; and inhibited CDK2, CDK6, cyclin D1, cyclin D3, and cyclin E in a dose-dependent manner.	pirfenidone	41-52	cyclin D1	Homo sapiens	286-295
28537766-9	2017	The expression of CDK2, CDK6, cyclin D1, and cyclin D3 were inhibited by LY294002, U0126, and SP600125.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	cyclin D1	Homo sapiens	30-39
28537766-9	2017	The expression of CDK2, CDK6, cyclin D1, and cyclin D3 were inhibited by LY294002, U0126, and SP600125.	U 0126	83-88	cyclin D1	Homo sapiens	30-39
28537766-9	2017	The expression of CDK2, CDK6, cyclin D1, and cyclin D3 were inhibited by LY294002, U0126, and SP600125.	pyrazolanthrone	94-102	cyclin D1	Homo sapiens	30-39
28537766-10	2017	SB202190 attenuated the pirfenidone-induced reduction of CDK2, CDK6, cyclin D1, cyclin D3, and cyclin E. CONCLUSIONS: Pirfenidone inhibited HTFs proliferation and induced G1 arrest by downregulating CDKs and cyclins involving the AKT/GSK3beta and MAPK signaling pathways.	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	0-8	cyclin D1	Homo sapiens	69-78
28537766-10	2017	SB202190 attenuated the pirfenidone-induced reduction of CDK2, CDK6, cyclin D1, cyclin D3, and cyclin E. CONCLUSIONS: Pirfenidone inhibited HTFs proliferation and induced G1 arrest by downregulating CDKs and cyclins involving the AKT/GSK3beta and MAPK signaling pathways.	pirfenidone	24-35	cyclin D1	Homo sapiens	69-78
28537766-10	2017	SB202190 attenuated the pirfenidone-induced reduction of CDK2, CDK6, cyclin D1, cyclin D3, and cyclin E. CONCLUSIONS: Pirfenidone inhibited HTFs proliferation and induced G1 arrest by downregulating CDKs and cyclins involving the AKT/GSK3beta and MAPK signaling pathways.	pirfenidone	118-129	cyclin D1	Homo sapiens	69-78
28498474-7	2017	Furthermore, overexpression of miR-1244 promoted caspase-3 activity and p53 and Bax protein expression, and suppressed myocyte enhancer factor 2D (MEF2D) and cyclin D1 protein expression in cisplatin-treated A549 and NCI-H522 cells.	Cisplatin	190-199	cyclin D1	Homo sapiens	158-167
28498474-8	2017	Small interfering RNA (siRNA) targeting MEF2D suppressed the protein expression of MEF2D, and was able to decrease the proliferation, promote caspase-3 activity, p53 and Bax protein expression and inhibit cyclin D1 protein expression in cisplatin-treated A549 and NCI-H522 cells following the overexpression of miR-1244.	Cisplatin	237-246	cyclin D1	Homo sapiens	205-214
28588729-7	2017	Western blotting revealed that grifolin treatment resulted in inactivation of protein kinase B (Akt) and extracellular signal-related kinase 1/2 (ERK1/2), accompanied by upregulation of Bcl-2 associated X, apoptosis regulator, cleaved-caspase-3 and cleaved-poly (ADP-ribose) polymerase, and downregulation of B cell lymphoma-2, cyclin dependent kinase 4 and cyclinD1.	grifolin	31-39	cyclin D1	Homo sapiens	358-366
29442024-0	2017	Anti-cancer activity of Bacillus amyloliquefaciens AK-0 through cyclin D1 proteasomal degradation via GSK3beta-dependent phosphorylation of threonine-286.	Threonine	140-149	cyclin D1	Homo sapiens	64-73
29442024-5	2017	Inhibition of proteasomal degradation by MG132 blocked EA-AK0-mediated cyclin D1 downregulation and the half-life of cyclin D1 was decreased in the cells treated with MRB.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	41-46	cyclin D1	Homo sapiens	71-80
29442024-6	2017	In addition, EA-AK0 increased threonine-286 (T286) phosphorylation of cyclin D1, and a point mutation of T286 to alanine attenuated cyclin D1 degradation by EA-AK0.	Threonine	30-39	cyclin D1	Homo sapiens	70-79
29442024-6	2017	In addition, EA-AK0 increased threonine-286 (T286) phosphorylation of cyclin D1, and a point mutation of T286 to alanine attenuated cyclin D1 degradation by EA-AK0.	C.I. Basic Blue 54	45-49	cyclin D1	Homo sapiens	70-79
29442024-6	2017	In addition, EA-AK0 increased threonine-286 (T286) phosphorylation of cyclin D1, and a point mutation of T286 to alanine attenuated cyclin D1 degradation by EA-AK0.	Alanine	113-120	cyclin D1	Homo sapiens	132-141
29442024-7	2017	Inhibition of GSK3beta by LiCl suppressed cyclin D1 phosphorylation and downregulation by EA-AKO.	Lithium Chloride	26-30	cyclin D1	Homo sapiens	42-51
28656880-9	2017	Functionally, targeting beta-catenin with lipofection-delivered small interfering RNA oligonucleotide inhibited the proliferation and cell cycle arrest in G0/G1 phase and increased apoptosis of fibroblast cells, accompanied by downregulation of Wnt2 and cyclin D1 as well as the phosphorylation level of glycogen synthase kinase 3 beta in the keloid fibrosis.	Oligonucleotides	86-101	cyclin D1	Homo sapiens	254-263
28558682-9	2017	Meanwhile, the expression of several regulators that contribute to G1/S phased transition, such as Cyclin D1, CDK4 and CDK6, were significantly down-regulated with the up-regulation of cell cycle inhibitors, p21 and p53, after treatment with glucosamine.	Glucosamine	242-253	cyclin D1	Homo sapiens	99-108
28915591-7	2017	Furthermore eugenol for external (1 mg) markedly decreased the protein expressions of HER2 (62.9%), AKT (58.6%), PDK1 (56.4%), p85 (54.3%), Bcl2 (59.3%), NF-kappaB (65.7%), Bad (64.0%), Cyclin D1 (43.0%), while p21, p27 and Bax protein expressions were respectively increased 1.83-, 2.52- and 2.51-fold.	Eugenol	12-19	cyclin D1	Homo sapiens	186-195
28415726-3	2017	Indeed, cyclin D1, COX-2, iNOS and c-Myc mRNA levels are upregulated following PGE2 treatment.	Dinoprostone	79-83	cyclin D1	Homo sapiens	8-17
28338993-8	2017	Notably, DHCE reduced the expression of cyclin D1 and cyclin-dependent kinases 4 and 6 in MM cell lines.	dhce	9-13	cyclin D1	Homo sapiens	40-49
28415819-0	2017	Aspirin regulation of c-myc and cyclinD1 proteins to overcome tamoxifen resistance in estrogen receptor-positive breast cancer cells.	Aspirin	0-7	cyclin D1	Homo sapiens	32-40
28415819-0	2017	Aspirin regulation of c-myc and cyclinD1 proteins to overcome tamoxifen resistance in estrogen receptor-positive breast cancer cells.	Tamoxifen	62-71	cyclin D1	Homo sapiens	32-40
28415819-4	2017	Aspirin combined with tamoxifen can down regulate cyclinD1 and block cell cycle in G0/G1 phase.	Aspirin	0-7	cyclin D1	Homo sapiens	50-58
28415819-4	2017	Aspirin combined with tamoxifen can down regulate cyclinD1 and block cell cycle in G0/G1 phase.	Tamoxifen	22-31	cyclin D1	Homo sapiens	50-58
28415819-5	2017	Besides, tamoxifen alone represses c-myc, progesterone receptor (PR) and cyclinD1 in MCF-7 cell line but not in MCF-7/TAM, while aspirin combined with tamoxifen can inhibit the expression of these proteins in the resistant cell line.	Tamoxifen	9-18	cyclin D1	Homo sapiens	73-81
28415819-5	2017	Besides, tamoxifen alone represses c-myc, progesterone receptor (PR) and cyclinD1 in MCF-7 cell line but not in MCF-7/TAM, while aspirin combined with tamoxifen can inhibit the expression of these proteins in the resistant cell line.	Tamoxifen	151-160	cyclin D1	Homo sapiens	73-81
28415819-6	2017	When knocking down c-myc in MCF-7/TAM, cells become more sensitive to tamoxifen, cell cycle is blocked as well, indicating that aspirin can regulate c-myc and cyclinD1 proteins to overcome tamoxifen resistance.	Tamoxifen	70-79	cyclin D1	Homo sapiens	159-167
28415819-6	2017	When knocking down c-myc in MCF-7/TAM, cells become more sensitive to tamoxifen, cell cycle is blocked as well, indicating that aspirin can regulate c-myc and cyclinD1 proteins to overcome tamoxifen resistance.	Aspirin	128-135	cyclin D1	Homo sapiens	159-167
28415819-6	2017	When knocking down c-myc in MCF-7/TAM, cells become more sensitive to tamoxifen, cell cycle is blocked as well, indicating that aspirin can regulate c-myc and cyclinD1 proteins to overcome tamoxifen resistance.	Tamoxifen	189-198	cyclin D1	Homo sapiens	159-167
28275987-4	2017	Consistently, smenospongidine down-regulated beta-catenin expression and repressed the levels of beta-catenin/T cell factor-dependent genes such as axin2, c-myc, and cyclin D1 in RPMI-8226 multiple myeloma cells.	Smenospongidine	14-29	cyclin D1	Homo sapiens	166-175
28292011-5	2017	Further study of the molecular mechanisms of this cytotoxic compound demonstrated that Jatamanvaltrate P enhanced cleavage of PARP and caspases, while decreased the expression levels of cell cycle-related Cyclin B1, Cyclin D1 and Cdc-2.	jatamanvaltrate P	87-104	cyclin D1	Homo sapiens	216-225
28610415-8	2017	Conclusion: The data provideevidence that synergistic antiproliferative effects of Chrysin and Silibinin are linked to the down-regulation of cyclinD1 and hTERT genes, and suggest that their combination may have therapeutic value in treatment of breast cancer.	chrysin	83-90	cyclin D1	Homo sapiens	142-150
28610415-8	2017	Conclusion: The data provideevidence that synergistic antiproliferative effects of Chrysin and Silibinin are linked to the down-regulation of cyclinD1 and hTERT genes, and suggest that their combination may have therapeutic value in treatment of breast cancer.	Silybin	95-104	cyclin D1	Homo sapiens	142-150
28193521-7	2017	The MAGL inhibitor URB602 reduced xenograft tumor volume, this effect being associated to down-regulation of VEGF and FGF-2, reduction in the number of vessels and down-regulation of cyclin D1.	URB602	19-25	cyclin D1	Homo sapiens	183-192
27762064-0	2017	CCND1-BCL2 Gene Network: A direct target of Amifostine in human acute megakaryocytic leukemia cells.	Amifostine	44-54	cyclin D1	Homo sapiens	0-5
27762064-5	2017	Through whole-genome microarray and bioinformatics analyses, we found that amifostine affected the gene expression of CCND1, BCL2, and CASP3 which revealed the mechanism amifostine acted on Dami cells.	Amifostine	75-85	cyclin D1	Homo sapiens	118-123
27762064-5	2017	Through whole-genome microarray and bioinformatics analyses, we found that amifostine affected the gene expression of CCND1, BCL2, and CASP3 which revealed the mechanism amifostine acted on Dami cells.	Amifostine	170-180	cyclin D1	Homo sapiens	118-123
27762064-6	2017	Thus, CCND1-BCL2 Gene Network is predicted to be a direct target of amifostine treating human acute megakaryocytic leukemia, which may provide a novel potential target for the therapy of several subtypes of human AML.	Amifostine	68-78	cyclin D1	Homo sapiens	6-11
28393191-4	2017	TSA also induces an elevated expression of cell cycle inhibitory protein p21Cip1 along with a decrease in cell cycle regulatory protein cyclin D1.	trichostatin A	0-3	cyclin D1	Homo sapiens	136-145
28212533-6	2017	Western blot analysis showed that compared with their expression when TGF-beta1 inhibitor LY2109761 was not added, N-Cadherin and CyclinD1 expression decreased and E-Cadherin expression increased.	LY2109761	90-99	cyclin D1	Homo sapiens	130-138
28343940-0	2017	Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G0/G1 Arrest by Inhibiting Deubiquitinase USP2a.	(4R)-N-hydroxy-4-[(3R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanamide	0-29	cyclin D1	Homo sapiens	43-52
28343940-3	2017	The most potent LCA derivative, LCA hydroxyamide (LCAHA), inhibits USP2a, leading to a significant Akt/GSK3beta-independent destabilization of cyclin D1, but does not change the expression of p27.	Lithocholic Acid	16-19	cyclin D1	Homo sapiens	143-152
28343940-3	2017	The most potent LCA derivative, LCA hydroxyamide (LCAHA), inhibits USP2a, leading to a significant Akt/GSK3beta-independent destabilization of cyclin D1, but does not change the expression of p27.	lca hydroxyamide	32-48	cyclin D1	Homo sapiens	143-152
28343940-3	2017	The most potent LCA derivative, LCA hydroxyamide (LCAHA), inhibits USP2a, leading to a significant Akt/GSK3beta-independent destabilization of cyclin D1, but does not change the expression of p27.	LCAHA	50-55	cyclin D1	Homo sapiens	143-152
28343940-5	2017	As a result, LCAHA inhibits the growth of cyclin D1-expressing, but not cyclin D1-negative cells, independently of the p53 status.	LCAHA	13-18	cyclin D1	Homo sapiens	42-51
28343940-6	2017	We show that LCA derivatives may be considered as future therapeutics for the treatment of cyclin D1-addicted p53-expressing and p53-defective cancer types.	Lithocholic Acid	13-16	cyclin D1	Homo sapiens	91-100
28212533-16	2017	The cell cycle, cell invasion, and levels of Cyclin-D1, E-Cadherin, and N-Cadherin were observed after adding TGF-beta1 inhibitor LY2109761 in the C4-2-PlncRNA-1 group.	LY2109761	130-139	cyclin D1	Homo sapiens	45-54
28469807-10	2017	Both protein-bound and unbound P-cresol enhanced the expression of p21Cip1 (0.62 and 0.60, both P&lt;0.05) and suppressed the expression of cyclin D1 (0.49 and 0.53, both P&lt;0.05) in a dose-dependent manner.	4-cresol	31-39	cyclin D1	Homo sapiens	140-149
28412732-5	2017	We also evaluated the expression of HSP90 by immunohistochemistry in human GBC tumors.In vitro assays showed that 17-AAG and GA significantly reduced the expression of HSP90 target proteins, including EGFR, AKT, phospho-AKT, Cyclin B1, phospho-ERK and Cyclin D1.	geldanamycin	125-127	cyclin D1	Homo sapiens	252-261
28469807-11	2017	In conclusion, unbound and protein-bound P-cresol inhibit the HUVEC proliferation by inducing cell cycle arrest at G0/G1 phase in a dose- and time-dependent manner, which associates with the up-regulation of p21Cip1 and down-regulation of cyclin D1.	4-cresol	41-49	cyclin D1	Homo sapiens	239-248
28435223-10	2017	In addition, results also found that, after treatment by NVP-BEZ235, phosphorylation levels of Akt kinase and S6K kinase significantly reduced, and the expression levels of cleaved caspase-3 significantly increased; meanwhile, the expression levels of caspase-3, B-cell lymphoma-2, cyclin D1, and cyclin D2 significantly decreased, and the ratio of LC3II/LC3I was significantly increased with increased LC3II expression level.	dactolisib	61-67	cyclin D1	Homo sapiens	282-291
28428754-6	2017	In particular, the JNK-specific inhibitor SP600125 restored the induction of P-JNK, P-p53 (Ser15), p21, CyclinD1 and CyclinE by Pu-erh tea extract.	pyrazolanthrone	42-50	cyclin D1	Homo sapiens	104-112
28428754-6	2017	In particular, the JNK-specific inhibitor SP600125 restored the induction of P-JNK, P-p53 (Ser15), p21, CyclinD1 and CyclinE by Pu-erh tea extract.	pu-erh	128-134	cyclin D1	Homo sapiens	104-112
29871302-8	2017	The combination of metformin and 5-fluorouracil produced an antagonism action in Hep-2 cells.Western blot assay showed that metformin, cisplatin, 5-fluorouracil could have caused the increase of expression level of AMPK-alpha, P21 and Cyclin D1 in Hep-2 cells while Paclitaxel could have cause the decrease of expression level of Cyclin D1.	Metformin	124-133	cyclin D1	Homo sapiens	235-244
29871302-8	2017	The combination of metformin and 5-fluorouracil produced an antagonism action in Hep-2 cells.Western blot assay showed that metformin, cisplatin, 5-fluorouracil could have caused the increase of expression level of AMPK-alpha, P21 and Cyclin D1 in Hep-2 cells while Paclitaxel could have cause the decrease of expression level of Cyclin D1.	Metformin	124-133	cyclin D1	Homo sapiens	330-339
29871302-8	2017	The combination of metformin and 5-fluorouracil produced an antagonism action in Hep-2 cells.Western blot assay showed that metformin, cisplatin, 5-fluorouracil could have caused the increase of expression level of AMPK-alpha, P21 and Cyclin D1 in Hep-2 cells while Paclitaxel could have cause the decrease of expression level of Cyclin D1.	Cisplatin	135-144	cyclin D1	Homo sapiens	235-244
29871302-8	2017	The combination of metformin and 5-fluorouracil produced an antagonism action in Hep-2 cells.Western blot assay showed that metformin, cisplatin, 5-fluorouracil could have caused the increase of expression level of AMPK-alpha, P21 and Cyclin D1 in Hep-2 cells while Paclitaxel could have cause the decrease of expression level of Cyclin D1.	Cisplatin	135-144	cyclin D1	Homo sapiens	330-339
29871302-8	2017	The combination of metformin and 5-fluorouracil produced an antagonism action in Hep-2 cells.Western blot assay showed that metformin, cisplatin, 5-fluorouracil could have caused the increase of expression level of AMPK-alpha, P21 and Cyclin D1 in Hep-2 cells while Paclitaxel could have cause the decrease of expression level of Cyclin D1.	Fluorouracil	146-160	cyclin D1	Homo sapiens	235-244
29871302-8	2017	The combination of metformin and 5-fluorouracil produced an antagonism action in Hep-2 cells.Western blot assay showed that metformin, cisplatin, 5-fluorouracil could have caused the increase of expression level of AMPK-alpha, P21 and Cyclin D1 in Hep-2 cells while Paclitaxel could have cause the decrease of expression level of Cyclin D1.	Fluorouracil	146-160	cyclin D1	Homo sapiens	330-339
29871302-11	2017	Metformin has an antagonism on the anticancer effect to 5-fluorouracil in Hep-2 cells, and this antagonistic effect occurred partially through molecular signal pathways of AMPK-alpha, P21 and Cyclin D1 and it"s significantly related to the cell cycle arrest.	Metformin	0-9	cyclin D1	Homo sapiens	192-201
29871302-11	2017	Metformin has an antagonism on the anticancer effect to 5-fluorouracil in Hep-2 cells, and this antagonistic effect occurred partially through molecular signal pathways of AMPK-alpha, P21 and Cyclin D1 and it"s significantly related to the cell cycle arrest.	Fluorouracil	56-70	cyclin D1	Homo sapiens	192-201
28368390-2	2017	We here show that sesaminol, a sesame lignan, reduces the expression of cyclin D1 with decreasing mRNA expression levels, inhibiting mTORC1 signaling and promoting proteasomal degradation.	sesaminol	18-27	cyclin D1	Homo sapiens	72-81
28368390-6	2017	Furthermore, we screened other ANT2-binding compounds and found that the proliferator-activated receptor-gamma agonist troglitazone also reduced cyclin D1 expression in a multifaceted manner, analogous to that of the sesaminol treatment and ANT2 depletion.	Troglitazone	119-131	cyclin D1	Homo sapiens	145-154
28368390-7	2017	Therefore, the chemical biology approach using magnetic FG beads employed in the present study revealed that sesaminol bound to ANT2, which may pleiotropically upregulate cyclin D1 expression at the mRNA level and protein level with mTORC1 activation and protein stabilization.	sesaminol	109-118	cyclin D1	Homo sapiens	171-180
27539251-6	2017	Protein levels of cyclin E1, cyclin D1, Snail, and N-cadherin increased in response to fludioxonil as the reaction to E2, but these increases were not observed when fludioxonil was administered with ICI 182,780.	fludioxonil	87-98	cyclin D1	Homo sapiens	29-38
28529629-10	2017	Niclosamide caused a dose- and time-dependent reduction of beta-catenin and the key components [e.g., DVLs, phospho-GSK3beta (S9), c-Myc and Cyclin D1] in the canonical Wnt/beta-catenin pathway.	Niclosamide	0-11	cyclin D1	Homo sapiens	141-150
28443465-9	2017	Furthermore, bauerenol-mediated S-phase arrest was associated with downregulation of cell cycle-rate-limiting factor (cyclin D1) and upregulation of cyclin-dependent kinase inhibitor p21 and tumor suppressor p53.	bauerenol	13-22	cyclin D1	Homo sapiens	118-127
28030785-4	2017	We found that low concentrations of 4-HNE (0.1 and 1muM) stimulated cell proliferation by enhancing cyclin D1 and c-Myc expression in primary HPASMCs.	4-hydroxy-2-nonenal	36-41	cyclin D1	Homo sapiens	100-109
28103884-11	2017	Mechanistically, Induction of AhR/CYP1A1 by TCDD and DMBA was associated with significant increase in beta-Catenin mRNA and protein expression, nuclear translocation and its downstream target Cyclin D1, whereas AhR or CYP1A1 knockdown using shRNA dramatically inhibited beta-Catenin cellular content and nuclear translocation.	Polychlorinated Dibenzodioxins	44-48	cyclin D1	Homo sapiens	192-201
30090515-5	2017	The results showed that low concentration arsenite increased the expressions of proliferative factors BCL2, cyclin D1, COX-2, MMP1 and PCNA in SV-HUC-1 cells, and ATF2 siRNA partly decreased the expressions of BCL2, cyclin D1, and COX-2.	arsenite	42-50	cyclin D1	Homo sapiens	108-117
30090515-5	2017	The results showed that low concentration arsenite increased the expressions of proliferative factors BCL2, cyclin D1, COX-2, MMP1 and PCNA in SV-HUC-1 cells, and ATF2 siRNA partly decreased the expressions of BCL2, cyclin D1, and COX-2.	arsenite	42-50	cyclin D1	Homo sapiens	216-225
28264020-13	2017	Our findings thus suggest that quercetin can significantly inhibit HepG2 cell proliferation, and this effect may be achieved through the regulation of cyclin D1 expression.	Quercetin	31-40	cyclin D1	Homo sapiens	151-160
28002618-7	2017	Treatment with verteporfin led to downregulation of cyclinD1 and cyclinE1, modulation of Bcl-2 family proteins and activation of PARP.	Verteporfin	15-26	cyclin D1	Homo sapiens	52-60
28611319-12	2017	Also, increase in intake of Vitamin E might help in reducing the risk of recurrence in KCOT by reducing the dysregulation of Cyclin D1 and Down-Regulation of mutant p53.	Vitamin E	28-37	cyclin D1	Homo sapiens	125-134
27338091-5	2017	Finally, in contrast to depletion or inhibition of cyclin-dependent kinase 4, CCND1 depletion increased chemosensitivity of MCL cells to replication inhibitors hydroxyurea and cytarabine.	Hydroxyurea	160-171	cyclin D1	Homo sapiens	78-83
27338091-5	2017	Finally, in contrast to depletion or inhibition of cyclin-dependent kinase 4, CCND1 depletion increased chemosensitivity of MCL cells to replication inhibitors hydroxyurea and cytarabine.	Cytarabine	176-186	cyclin D1	Homo sapiens	78-83
28025797-7	2017	Molecular docking was performed to understand the possible interaction between nimbolide and Akt, PCNA, and Cyclin D1.	nimbolide	79-88	cyclin D1	Homo sapiens	108-117
27996348-5	2017	Compared with FZD alone group, curcumin pretreatment significantly reduced the expression of phospho (p)-p38, cyclin D1, p-checkpoint kinase 1 (ChK1) and breast cancer associated gene 1 (BRCA1) protein, followed to attenuate S phase arrest.	Curcumin	31-39	cyclin D1	Homo sapiens	110-119
28347255-6	2017	We also demonstrated that JPH203 induced both G2/M and G0/G1 cell cycle arrest, as well as reduced the S phase accompanied by altered expression of the proteins in cell cycle progression: cyclin D1, CDK4, and CDK6.	2-amino-3-(4-((5-amino-2-phenylbenzo(d)oxazol-7-yl)methoxy)-3,5-dichlorophenyl)propanoic acid	26-32	cyclin D1	Homo sapiens	188-197
28245605-7	2017	Furthermore, TTB selectively inhibited STAT3 activation, which resulted in a reduction in cyclin D1, MMP-9, survivin, VEGF, and IL-6.	Thenoyltrifluoroacetone	13-16	cyclin D1	Homo sapiens	90-99
28231299-5	2017	Therefore, we suggest miR-34a-5p/miR-34c-5p/miR-302b-3p -LEF1-CCND1/WNT1/MYC axis may be a crucial mechanism in inhibition of lung cancer metastasis by curcumin.	Curcumin	152-160	cyclin D1	Homo sapiens	62-67
28038705-6	2017	In 4 cases, at least 20% of LP cells were positive for CD20/cyclin D1.	leucylproline	28-30	cyclin D1	Homo sapiens	60-69
28038705-9	2017	Two of 5 cases of THRLBCL showed rare positive staining for CD20/cyclin D1; 1 case showed polysomy with CCND1/CEP11.	thrlbcl	18-25	cyclin D1	Homo sapiens	65-74
28038429-10	2017	AMD3100 plus triptolide induced proliferation inhibition and apoptosis of U2OS cells, which was attributed to the downregulation of c-Myc, survivin, cyclin D1 and increased cleaved caspase-3 and PARP.	triptolide	13-23	cyclin D1	Homo sapiens	149-158
28061416-4	2017	Interestingly, activation of P2X7R by stimulating with P2X7R agonist BzATP significantly promoted acetaldehyde-induced CyclinD1 expression, cell proportion in S phase, inflammatory response, and the protein and mRNA levels of alpha-SMA, collagen I.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	69-74	cyclin D1	Homo sapiens	119-127
28061416-4	2017	Interestingly, activation of P2X7R by stimulating with P2X7R agonist BzATP significantly promoted acetaldehyde-induced CyclinD1 expression, cell proportion in S phase, inflammatory response, and the protein and mRNA levels of alpha-SMA, collagen I.	Acetaldehyde	98-110	cyclin D1	Homo sapiens	119-127
28101580-12	2017	MeOH fraction arrested HepG2 cells at the G0/G1 phase in a concentration-dependent manner, and resulted in decreased expression of cyclin D1, cyclin E, cyclin-dependent kinase (CDK)2, CDK4, CDK6, p21, and p27.	Methanol	0-4	cyclin D1	Homo sapiens	131-140
27592355-3	2017	RESULTS: Cellular viability revealed that high doses of hydroxytyrosol reduced cancer cells viability concomitantly with a reduction of cyclin D1 expression and an up-regulation of cell cycle key modulator p21 levels.	3,4-dihydroxyphenylethanol	56-70	cyclin D1	Homo sapiens	136-145
27743340-10	2017	However, downregulation of p16INK4a and hypophosphorylated-pRb and cyclin D1 protein expressions (p &lt; 0.05) by gamma-tocotrienol led to modulation of the cell cycle regulation during cellular aging.	plastochromanol 8	114-131	cyclin D1	Homo sapiens	67-76
27128966-0	2017	Metformin induces degradation of cyclin D1 via AMPK/GSK3beta axis in ovarian cancer.	Metformin	0-9	cyclin D1	Homo sapiens	33-42
27128966-3	2017	Here, we first describe that the anti-cancer effect of metformin is mediated by cyclin D1 deregulation via AMPK/GSK3beta axis in ovarian cancer cells.	Metformin	55-64	cyclin D1	Homo sapiens	80-89
27128966-5	2017	Metformin induced the G1 cell cycle arrest, in parallel with a decrease in the protein expressions of cyclin D1 without affecting its transcriptional levels.	Metformin	0-9	cyclin D1	Homo sapiens	102-111
27128966-6	2017	Using a proteasomal inhibitor, we could address that metformin-induced decrease in cyclin D1 through the ubiquitin/proteasome process.	Metformin	53-62	cyclin D1	Homo sapiens	83-92
27128966-7	2017	Cyclin D1 degradation by metformin requires the activation of GSK3beta, as determined based on the treatment with GSK3beta inhibitors.	Metformin	25-34	cyclin D1	Homo sapiens	0-9
27128966-9	2017	These findings suggested that the anticancer effects of metformin was induced due to cyclin D1 degradation via AMPK/GSK3beta signaling axis that involved the ubiquitin/proteasome pathway specifically in ovarian cancer cells.	Metformin	56-65	cyclin D1	Homo sapiens	85-94
27959426-16	2017	Phosphorylation of CREB and induction of c-fos, cyclin D1 and aromatase expression by 17beta-estradiol were all prevented by gefitinib.	Estradiol	86-102	cyclin D1	Homo sapiens	48-57
27959426-16	2017	Phosphorylation of CREB and induction of c-fos, cyclin D1 and aromatase expression by 17beta-estradiol were all prevented by gefitinib.	Gefitinib	125-134	cyclin D1	Homo sapiens	48-57
28356961-8	2017	In addition, levels of Cyclin D1 expression decreased in cells exposed to 3 microM sorafenib and 1 microM 2DG compared with cells exposed to 2DG or sorafenib alone (P&lt;0.05).	Sorafenib	83-92	cyclin D1	Homo sapiens	23-32
28356961-8	2017	In addition, levels of Cyclin D1 expression decreased in cells exposed to 3 microM sorafenib and 1 microM 2DG compared with cells exposed to 2DG or sorafenib alone (P&lt;0.05).	Deoxyglucose	106-109	cyclin D1	Homo sapiens	23-32
28356961-8	2017	In addition, levels of Cyclin D1 expression decreased in cells exposed to 3 microM sorafenib and 1 microM 2DG compared with cells exposed to 2DG or sorafenib alone (P&lt;0.05).	Deoxyglucose	141-144	cyclin D1	Homo sapiens	23-32
28356961-8	2017	In addition, levels of Cyclin D1 expression decreased in cells exposed to 3 microM sorafenib and 1 microM 2DG compared with cells exposed to 2DG or sorafenib alone (P&lt;0.05).	Sorafenib	148-157	cyclin D1	Homo sapiens	23-32
27806920-0	2017	Casearin D inhibits ERK phosphorylation and induces downregulation of cyclin D1 in HepG2 cells.	casearin D	0-10	cyclin D1	Homo sapiens	70-79
27988424-5	2017	Based on these findings, we speculated that miR-3940-5p might target CCND1 and USP28 to inhibit NSCLC growth.	mir-3940-5p	44-55	cyclin D1	Homo sapiens	69-74
27988424-7	2017	Cell proliferation and apoptosis assays showed that miR-3940-5p suppressed proliferation and promoted apoptosis in NSCLC cells, and silencing CCND1 and USP28 both recapitulated the effects of miR-3940-5p on NSCLC cells.	mir-3940	192-200	cyclin D1	Homo sapiens	142-147
28103884-11	2017	Mechanistically, Induction of AhR/CYP1A1 by TCDD and DMBA was associated with significant increase in beta-Catenin mRNA and protein expression, nuclear translocation and its downstream target Cyclin D1, whereas AhR or CYP1A1 knockdown using shRNA dramatically inhibited beta-Catenin cellular content and nuclear translocation.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	53-57	cyclin D1	Homo sapiens	192-201
28098804-5	2017	The results showed that olaquindox could induce reactive oxygen species (ROS)-mediated DNA damage and S-phase arrest, where increases of GADD45a, cyclin A, Cdk 2, p21 and p53 protein expression, decrease of cyclin D1 and the activation of phosphorylation-c-Jun N-terminal kinases (p-JNK), phosphorylation-p38 (p-p38) and phosphorylation-extracellular signal-regulated kinases (p-ERK) were involved.	olaquindox	24-34	cyclin D1	Homo sapiens	207-216
27270423-0	2017	miR-374a-CCND1-pPI3K/AKT-c-JUN feedback loop modulated by PDCD4 suppresses cell growth, metastasis, and sensitizes nasopharyngeal carcinoma to cisplatin.	Cisplatin	143-152	cyclin D1	Homo sapiens	9-14
29871302-8	2017	The combination of metformin and 5-fluorouracil produced an antagonism action in Hep-2 cells.Western blot assay showed that metformin, cisplatin, 5-fluorouracil could have caused the increase of expression level of AMPK-alpha, P21 and Cyclin D1 in Hep-2 cells while Paclitaxel could have cause the decrease of expression level of Cyclin D1.	Metformin	19-28	cyclin D1	Homo sapiens	235-244
29871302-8	2017	The combination of metformin and 5-fluorouracil produced an antagonism action in Hep-2 cells.Western blot assay showed that metformin, cisplatin, 5-fluorouracil could have caused the increase of expression level of AMPK-alpha, P21 and Cyclin D1 in Hep-2 cells while Paclitaxel could have cause the decrease of expression level of Cyclin D1.	Metformin	19-28	cyclin D1	Homo sapiens	330-339
29871302-8	2017	The combination of metformin and 5-fluorouracil produced an antagonism action in Hep-2 cells.Western blot assay showed that metformin, cisplatin, 5-fluorouracil could have caused the increase of expression level of AMPK-alpha, P21 and Cyclin D1 in Hep-2 cells while Paclitaxel could have cause the decrease of expression level of Cyclin D1.	Fluorouracil	33-47	cyclin D1	Homo sapiens	235-244
29871302-8	2017	The combination of metformin and 5-fluorouracil produced an antagonism action in Hep-2 cells.Western blot assay showed that metformin, cisplatin, 5-fluorouracil could have caused the increase of expression level of AMPK-alpha, P21 and Cyclin D1 in Hep-2 cells while Paclitaxel could have cause the decrease of expression level of Cyclin D1.	Fluorouracil	33-47	cyclin D1	Homo sapiens	330-339
29120119-2	2017	Immunohistochemistry was performed on formalin-fixed, paraffin-embeddedtissue by the RET, p27 and cyclin D1 antibodies.	Paraffin	54-62	cyclin D1	Homo sapiens	98-107
28062277-6	2017	In these cells, arsenite induced increases of EZH2 and cyclin D1 and accelerated the cell cycle.	arsenite	16-24	cyclin D1	Homo sapiens	55-64
28062277-8	2017	Further, in HaCaT cells exposed to arsenite, EZH2 regulated the cell cycle by binding to the promoter of CCND1, which codes for cyclin D1.	arsenite	35-43	cyclin D1	Homo sapiens	105-110
28062277-8	2017	Further, in HaCaT cells exposed to arsenite, EZH2 regulated the cell cycle by binding to the promoter of CCND1, which codes for cyclin D1.	arsenite	35-43	cyclin D1	Homo sapiens	128-137
28062277-11	2017	These results suggest that, in HaCaT cells, arsenite increases circ100284 levels, which act as a sponge for miR-217 and up-regulate the miR-217 target, EZH2, which, in turn, up-regulates cyclin D1and CDK4, and thus accelerates the cell cycle and leads to malignant transformation.	arsenite	44-52	cyclin D1	Homo sapiens	187-196
28098854-7	2017	This is because the inhibition of LSD1 induces dimethylation of lysine 9 on histone H3 (H3K9m2) accumulation at the promoter region of cyclin D1.	Lysine	64-70	cyclin D1	Homo sapiens	135-144
28092744-4	2017	In this study, we found that quercetin inhibited PI3K/AKT/mTOR and STAT3 pathways in PEL cells, and as a consequence, it down-regulated the expression of the prosurvival cellular proteins such as c-FLIP, cyclin D1 and cMyc.	Quercetin	29-38	cyclin D1	Homo sapiens	204-213
27956520-4	2017	BTMB inhibited the expression of beta-catenin, cdc2 and the cell-cycle regulatory proteins, cyclin A, cyclin D1, and cyclin E. The mechanism of action was associated with the suppression of cell survival signaling through inactivation of the Akt and ERK1/2 signaling pathways.	3,5-Bis(trimethylsilyl)benzoic acid	0-4	cyclin D1	Homo sapiens	102-111
28119080-9	2017	3alpha-THP (10nM) increased the expression of TGFbeta1, EGFR, VEGF and cyclin D1 genes.	3alpha-thp	0-10	cyclin D1	Homo sapiens	71-80
28099142-0	2017	The pentapeptide Gly-Thr-Gly-Lys-Thr confers sensitivity to anti-cancer drugs by inhibition of CAGE binding to GSK3beta and decreasing the expression of cyclinD1.	glycyl-threonine	17-24	cyclin D1	Homo sapiens	153-161
28099142-0	2017	The pentapeptide Gly-Thr-Gly-Lys-Thr confers sensitivity to anti-cancer drugs by inhibition of CAGE binding to GSK3beta and decreasing the expression of cyclinD1.	Gly-Lys-Thr	25-36	cyclin D1	Homo sapiens	153-161
28099911-7	2017	The increase of pAkt, pERK1/2 and cyclin D1 by bradykinin was prevented by the PI3K inhibitor Ly294002, the PLC inhibitors U73122 and neomycin, and/or the PKC inhibitor chelerythrine and the MAPK inhibitor PD98059.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	94-102	cyclin D1	Homo sapiens	34-43
28099911-7	2017	The increase of pAkt, pERK1/2 and cyclin D1 by bradykinin was prevented by the PI3K inhibitor Ly294002, the PLC inhibitors U73122 and neomycin, and/or the PKC inhibitor chelerythrine and the MAPK inhibitor PD98059.	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	123-129	cyclin D1	Homo sapiens	34-43
28099911-7	2017	The increase of pAkt, pERK1/2 and cyclin D1 by bradykinin was prevented by the PI3K inhibitor Ly294002, the PLC inhibitors U73122 and neomycin, and/or the PKC inhibitor chelerythrine and the MAPK inhibitor PD98059.	Neomycin	134-142	cyclin D1	Homo sapiens	34-43
28052039-4	2017	In the dose- and time-dependent experiments, UA increased cell proliferation shown by the increased total cell number, DNA synthesis rate, and the number of cells in S and G2 phases in parallel with the upregulation of cyclin A2 and cyclin D1.	Uric Acid	45-47	cyclin D1	Homo sapiens	233-242
27894814-10	2017	Finally, the apoptotic molecules such as Bax/Bcl2, cleavage caspase 3 and the cell cycle regulation factors including p21, cyclin D1, and CDK6 were changed by Tanshinone IIA.	tanshinone	159-169	cyclin D1	Homo sapiens	123-132
27305912-9	2017	RESULTS: After adjusting for multiple comparisons in the 32 tumors from metformin-treated patients vs. 34 untreated historical controls, 11 proteins were significantly different between cases vs. CONTROLS: increases in Raptor, C-Raf, Cyclin B1, Cyclin D1, TRFC, and Syk; and reductions in pMAPKpT202,Y204, JNKpT183,pT185, BadpS112, PKC.alphapS657, and SrcpY416.	Metformin	72-81	cyclin D1	Homo sapiens	245-254
27305912-10	2017	Cyclin D1 change after metformin by IHC was not observed.	Metformin	23-32	cyclin D1	Homo sapiens	0-9
27766528-5	2017	Among the tested inhibitors, FH535 demonstrated a markedly suppressive effect (IC50 = 358 nM) on mRNA levels of beta-catenin target genes (LEF1, CCND1, and cMYC).	FH535	29-34	cyclin D1	Homo sapiens	145-150
28000897-7	2017	Mechanistically, signal transducer and activator of transcription 3 (Stat3) and its downstream targets Bcl-2, cyclin D1 and c-Myc was inactivated by bortezomib treatment.	Bortezomib	149-159	cyclin D1	Homo sapiens	110-119
27911270-3	2017	The treatment with SAHA increased the expression of acetyl-histones 3 and 4, which were recruited to the promoters of p21, p27, Cyclin D1, c-myc and Nanog to down-regulate their transcriptional levels.	Vorinostat	19-23	cyclin D1	Homo sapiens	128-137
27932253-0	2017	Regulation of cyclin D1 by arsenic and microRNA inhibits adipogenesis.	Arsenic	27-34	cyclin D1	Homo sapiens	14-23
28070171-9	2017	Moreover, casticin induced cycle arrest and apoptosis by upregulating p27 and downregulating cyclinD1/cyclin-dependent kinase4 and phosphorylated protein kinase B.	casticin	10-18	cyclin D1	Homo sapiens	93-126
27932253-6	2017	Exposing hMSCs to arsenic increased abundance of miR-29b and cyclin D1 to promote proliferation over differentiation.	Arsenic	18-25	cyclin D1	Homo sapiens	61-70
27932253-8	2017	This paradox was attributed to a requirement for miR-29 in regulating cyclin D1 expression as stable inhibition of miR-29b eliminated the cyclic pattern of cyclin D1 expression.	mir-29	49-55	cyclin D1	Homo sapiens	70-79
27932253-9	2017	Temporal regulation of cyclin D1 is critical for adipogenic differentiation, and the data suggest a paradigm where arsenic disruption of miR-29b regulatory pathways impairs adipogenic differentiation and ultimately adipose metabolic homeostasis.	Arsenic	115-122	cyclin D1	Homo sapiens	23-32
28045889-11	2017	It was shown that metformin downregulates the expression of cyclin D1 and increases the p27KIP1 level.	Metformin	18-27	cyclin D1	Homo sapiens	60-69
26478521-7	2017	RESULTS: DHTI treatment inhibited the proliferation of 143B cells in a dose- and time-dependent manner through arresting cells in G1 phase by reducing the expression of cyclin D1, cyclin E1, CDK2, CDK4, CDK6, p-Rb, E2F1, SKP2 and increasing the expression of P53, P21cip1, P27kip1.	dhts	9-13	cyclin D1	Homo sapiens	169-178
27816443-3	2017	In keratinocytes, lucidone-induced nuclear translocation of beta-catenin was accompanied by increased transcriptional target genes, including c-Myc and cyclin-D1, through GSK3beta-dependent pathway.	lucidone	18-26	cyclin D1	Homo sapiens	152-161
27491935-10	2017	Further, BPIQ down-regulates the pro-survival proteins, survivin, XIAP and cyclin D1.	9-bis(2-(pyrrolidin-1-yl)ethoxy)-6-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-11H-indeno(1,2-c)quinolin-11-one	9-13	cyclin D1	Homo sapiens	75-84
27816443-8	2017	Inhibition of PI3K/AKT signaling impaired the lucidone-induced proliferation/migration with corresponding suppression of beta-catenin/c-Myc/cyclin-D1 and NF-kappaB/MMP-9 expressions.	lucidone	46-54	cyclin D1	Homo sapiens	140-149
27889234-17	2017	Western blot shows that ICA could effectively down regulate the expression of cell cycle protein cyclin D1, while promoting the activation of Caspase 3, 8 and 9 when compared to curcumin in human colon cancer cell line SW480.	isocyanic acid	24-27	cyclin D1	Homo sapiens	97-106
28566619-7	2017	The inhibition was largely attributed to cell cycle arrest at the G1 phase through the reduction of cyclin D1, and cyclin E. Moreover, berberine could reduce the expression and activation of signal transducers and activator of transcription 3 (STAT3) and probably nuclear factor-kappaB (NF-kappaB) via suppression of extracellular signal-regulated kinase (ERK) 1/2 action.	Berberine	135-144	cyclin D1	Homo sapiens	100-109
28980866-6	2017	Therefore, these results indicate that NVP-BEZ235-induced cyclin D1 and cyclin E1 degradation, which happened through activating GSK3beta, and GSK3beta-dependent down-regulation of cyclin D1 and cyclin E1 should be available for anticancer therapeutics.	dactolisib	43-49	cyclin D1	Homo sapiens	58-67
28386546-11	2017	After being treated with different concentrations of ethyl acetate extracts, the percentage of G0/G1 phase increased significantly, cyclin D1 and cyclin E expression decreased, apoptosis rate was significantly higher, and the ability of migration of PC-3 and RV1 was inhibited significantly.	ethyl acetate	53-66	cyclin D1	Homo sapiens	132-141
27761963-6	2017	2,5-Dimethylcelecoxib also inhibited the T-cell factor-dependent transcription activity and suppressed the expression of Wnt/beta-catenin target gene products cyclin D1 and survivin.	2,5-dimethylcelecoxib	0-21	cyclin D1	Homo sapiens	159-168
27743340-12	2017	Palm gamma-tocotrienol may delay cellular senescence of HDFs by regulating cell cycle through downregulation of p16INK4a and hypophosphorylated-pRb and cyclin D1 protein expressions.	plastochromanol 8	5-22	cyclin D1	Homo sapiens	152-161
28980866-6	2017	Therefore, these results indicate that NVP-BEZ235-induced cyclin D1 and cyclin E1 degradation, which happened through activating GSK3beta, and GSK3beta-dependent down-regulation of cyclin D1 and cyclin E1 should be available for anticancer therapeutics.	dactolisib	43-49	cyclin D1	Homo sapiens	181-190
29055954-9	2017	Western blotting confirmed that a higher concentration of artesunate reduced the expression levels of beta-catenin, cyclin A, cyclin D1 and CDK1 and increased the expression levels of cyclin B1; however, artesunate had no impact on CDK2 expression in MG-63 cells.	Artesunate	58-68	cyclin D1	Homo sapiens	126-135
26822619-4	2017	Furthermore, the decline in nuclear beta-catenin and cyclin D1 levels in hBMSCs exposed to BPA was reversed by MnTBAP treatment.	bisphenol A	91-94	cyclin D1	Homo sapiens	53-62
29131001-7	2017	We demonstrated that atorvastatin calcium induced cell cycle arrest in the G0/G1 phase in response to PDGF-betabeta stimulation and decreased the expression of G0/G1-specific regulatory proteins, including proliferating cell nuclear antigen (PCNA), CDK2, cyclin D1, cyclin E and CDK4 in PDGF-betabeta-treated VSMCs.	Atorvastatin	21-41	cyclin D1	Homo sapiens	255-264
28123594-13	2017	SAHA also caused cell cycle arrest by upregulation of CDKN1A and downregulation of CCND1 encoding p21WAF1/CIP1 and cyclin D1 proteins, respectively.	Vorinostat	0-4	cyclin D1	Homo sapiens	83-88
28123594-13	2017	SAHA also caused cell cycle arrest by upregulation of CDKN1A and downregulation of CCND1 encoding p21WAF1/CIP1 and cyclin D1 proteins, respectively.	Vorinostat	0-4	cyclin D1	Homo sapiens	115-124
27125297-5	2017	Our study showed out that naringin can inhibit cell proliferation by inhibiting FAK/cyclin D1 pathway, promote cell apoptosis through influencing FAK/bads pathway, at the same time, it can also inhibit cell invasion and metastasis by inhibiting the FAK/mmps pathway.	naringin	26-34	cyclin D1	Homo sapiens	84-93
28508842-10	2017	CONCLUSION: This study demonstrated that IB-MECA induces G1 phase cell cycle arrest through Cyclin D1/CDK4-mediated pathway in ovarian cancer cells.	N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine	41-48	cyclin D1	Homo sapiens	92-101
27761814-8	2017	HDACi, such as Vorinostat (Suberoylanilide hydroxamic acid (SAHA)), affect cancer cells in part by suppressing the translation of key proteins linked to tumorigenesis, such as cyclin D1 and hypoxia inducible factor 1 alpha (HIF-1alpha).	Vorinostat	27-58	cyclin D1	Homo sapiens	176-185
27761814-8	2017	HDACi, such as Vorinostat (Suberoylanilide hydroxamic acid (SAHA)), affect cancer cells in part by suppressing the translation of key proteins linked to tumorigenesis, such as cyclin D1 and hypoxia inducible factor 1 alpha (HIF-1alpha).	Vorinostat	60-64	cyclin D1	Homo sapiens	176-185
28123566-3	2017	The present study reported that resveratrol exhibited a marked anti-proliferative effect on human esophageal squamous cell carcinoma (ESCC) cells by inducing cell cycle G0/G1 phase arrest and cell death, which was associated with a decrease in the expression levels of cyclin D1 and an increase in cleaved PARP/cleaved caspase-3 expression levels.	Resveratrol	32-43	cyclin D1	Homo sapiens	269-278
28980866-3	2017	Moreover, we showed NVP-BEZ235 could induce neuroblastoma cells arrested at G0/G1 phase accompanied with significant reduction of the cyclin D1 and E1 proteins in a dose dependent manner at nanomole concentration.	dactolisib	24-30	cyclin D1	Homo sapiens	134-143
28010928-3	2017	Total triterpenes induced apoptosis in MCF-7 cells by down-regulating the levels of cyclin D1, Bcl-2, Bcl-xL and also by up-regulating the levels of Bax and caspase-9.	Triterpenes	6-17	cyclin D1	Homo sapiens	84-93
28030611-9	2016	PDGF-stimulated cell cycle in HTFs was delayed by silibinin, and the related cyclin D1 and CDK4 were also suppressed by silibinin.	Silybin	120-129	cyclin D1	Homo sapiens	77-86
28035994-7	2016	Mechanistically, pre-treatment with the proteasome inhibitor MG-132 restored cyclin D1 levels in all obatoclax-treated cell lines.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	61-67	cyclin D1	Homo sapiens	77-86
27863383-5	2016	Next, by using co-culture system of myeloma and adipocytes, and pharmacologic enhancement of leptin, we found that increased growth of myeloma cells and reduced toxicity of bortezomib were best observed at 50 ng/ml of leptin, along with increased expression of cyclinD1, Bcl-2 and decreased caspase-3 expression.	Bortezomib	173-183	cyclin D1	Homo sapiens	261-269
28035994-8	2016	Cycloheximide chase analyses further revealed an evident reduction in the half-life of cyclin D1 protein by obatoclax, confirming that obatoclax downregulates cyclin D1 through induction of cyclin D1 proteasomal degradation.	Cycloheximide	0-13	cyclin D1	Homo sapiens	87-96
28035994-8	2016	Cycloheximide chase analyses further revealed an evident reduction in the half-life of cyclin D1 protein by obatoclax, confirming that obatoclax downregulates cyclin D1 through induction of cyclin D1 proteasomal degradation.	Cycloheximide	0-13	cyclin D1	Homo sapiens	159-168
28035994-8	2016	Cycloheximide chase analyses further revealed an evident reduction in the half-life of cyclin D1 protein by obatoclax, confirming that obatoclax downregulates cyclin D1 through induction of cyclin D1 proteasomal degradation.	Cycloheximide	0-13	cyclin D1	Homo sapiens	159-168
28035994-9	2016	Lastly, threonine 286 phosphorylation of cyclin D1, which is essential for initiating cyclin D1 proteasomal degradation, was induced by obatoclax in one cell line but not others.	Threonine	8-17	cyclin D1	Homo sapiens	41-50
28035994-9	2016	Lastly, threonine 286 phosphorylation of cyclin D1, which is essential for initiating cyclin D1 proteasomal degradation, was induced by obatoclax in one cell line but not others.	Threonine	8-17	cyclin D1	Homo sapiens	86-95
27977759-3	2016	Viscolin reduced the PDGF-BB-induced HASMC proliferation and migration in vitro; it also arrested HASMCs in the G0/G1 phase by decreasing the protein expression of Cyclin D1, CDK2, Cyclin E, CDK4, and p21Cip1 as detected by Western blot analysis.	viscolin	0-8	cyclin D1	Homo sapiens	164-173
27686271-8	2016	Bufalin treatment inhibited cyclin D1 and cyclin E1 expression and therefore increased expression of p27, a regulatory molecular that controls cell cycle transition from S to G2 phase.	bufalin	0-7	cyclin D1	Homo sapiens	28-37
27973395-7	2016	In LNCaP, a human androgen-dependent prostate cancer cell line, PGZ also inhibited cyclin D1 expression and the activation of both p38 MAPK and NFkappaB.	Pioglitazone	64-67	cyclin D1	Homo sapiens	83-92
27519631-0	2016	Tamoxifen has a proliferative effect in endometrial carcinoma mediated via the GPER/EGFR/ERK/cyclin D1 pathway: A retrospective study and an in vitro study.	Tamoxifen	0-9	cyclin D1	Homo sapiens	93-102
27286739-7	2016	Overexpression of phosphorylated JAK1 (p-JAK1) and cyclin D1 was significantly overexpressed in ductal cells compared with myoepithelial cells in PA. A shift from p-JAK1 to p-JAK2 and p-Tyk2 overexpression was seen between PA and ca-ex-PA, combined with a high p-STAT3 expression in the latter.	ca-ex-pa	230-238	cyclin D1	Homo sapiens	51-60
27665868-10	2016	Moreover, inhibition of p53 partly reverses the UA-induced downregulation of beta-catenin, as do the targets of Wnt/beta-catenin signaling, such as c-Myc and cyclin D1.	ursolic acid	48-50	cyclin D1	Homo sapiens	158-167
27736002-4	2016	miR-105 up-regulation repressed the expression of SOX9, TCF4, c-MYC, cyclin D1, and AXIN2 and suppressed glioma cell progression.	mir-105	0-7	cyclin D1	Homo sapiens	69-78
27748837-6	2016	This study demonstrated that EMMQ induced DNA damage by activating p53 and gamma-H2AX and cell arrest by suppressing cyclin D1 and CDK2.	3-((7-ethyl-1H-indol-3-yl)-methyl)-2-methylquinoline	29-33	cyclin D1	Homo sapiens	117-126
27071708-6	2016	DNA translocations with cyclin D1 overexpression occur in PAs (8%).	Protactinium	58-61	cyclin D1	Homo sapiens	24-33
27779693-5	2016	Metformin upregulated the expression of p21Waf1 and p27kip1, and downregulated the expression of cyclin D1, a key protein required for cell cycle progression.	Metformin	0-9	cyclin D1	Homo sapiens	97-106
27779693-6	2016	The combination of gemcitabine and cisplatin inhibited the proliferation and induced the apoptosis of human cholangiocarcinoma cells by inducing the phosphorylation of AMPK, downregulating cyclin D1, and activating caspase-3.	gemcitabine	19-30	cyclin D1	Homo sapiens	189-198
27779693-6	2016	The combination of gemcitabine and cisplatin inhibited the proliferation and induced the apoptosis of human cholangiocarcinoma cells by inducing the phosphorylation of AMPK, downregulating cyclin D1, and activating caspase-3.	Cisplatin	35-44	cyclin D1	Homo sapiens	189-198
27779693-7	2016	Administration of metformin enhanced the efficacy of gemcitabine and cisplatin to suppress the growth of cholangiocarcinoma tumors established in experimental models by inhibiting cell proliferation and inducing cell apoptosis through their effects on AMPK, cyclin D1 and caspase-3.	Metformin	18-27	cyclin D1	Homo sapiens	258-267
27779693-7	2016	Administration of metformin enhanced the efficacy of gemcitabine and cisplatin to suppress the growth of cholangiocarcinoma tumors established in experimental models by inhibiting cell proliferation and inducing cell apoptosis through their effects on AMPK, cyclin D1 and caspase-3.	gemcitabine	53-64	cyclin D1	Homo sapiens	258-267
27779693-7	2016	Administration of metformin enhanced the efficacy of gemcitabine and cisplatin to suppress the growth of cholangiocarcinoma tumors established in experimental models by inhibiting cell proliferation and inducing cell apoptosis through their effects on AMPK, cyclin D1 and caspase-3.	Cisplatin	69-78	cyclin D1	Homo sapiens	258-267
28101212-8	2016	Finally, following treatment with a combination of PPC and L-OHP, the expression of cyclins D1 and E was downregulated; however, PPC did not alter the production of reactive oxygen species caused by L-OHP (P=0.88).	Oxaliplatin	59-64	cyclin D1	Homo sapiens	84-100
28024484-4	2016	The expression of CyclinD1 and p27kip1 in K562 cells treated with As2O3 was analyzed by reverse transcription-polymerase chain reaction(RT-PCR), immunohistochemistry and Western blot.	Arsenic Trioxide	66-71	cyclin D1	Homo sapiens	18-26
28024484-7	2016	As2O3 could markedly inhibit the expression of CyclinD1 in K562 cells(P&lt;0.05), but the expression of P27kip1 was not significantly changed after As2O3 treatment.	Arsenic Trioxide	0-5	cyclin D1	Homo sapiens	47-55
28024484-8	2016	CONCLUSIONS: As2O3 can induce K562 cell apoptosis and inhibit K562 cell proliferation by regulating the expression of CyclinD1.	Arsenic Trioxide	13-18	cyclin D1	Homo sapiens	118-126
27793037-8	2016	Chronic hypoxia suppressed the expression of cyclinD1, CDK4, and CDK6, inducing G1 phase block and 5-flurouracil (5-FU) chemoresistance.	5-flurouracil	99-112	cyclin D1	Homo sapiens	45-53
27793037-8	2016	Chronic hypoxia suppressed the expression of cyclinD1, CDK4, and CDK6, inducing G1 phase block and 5-flurouracil (5-FU) chemoresistance.	Fluorouracil	114-118	cyclin D1	Homo sapiens	45-53
27793037-9	2016	Overexpression of c-Myc reversed the inhibition of cyclinD1, CDK4, and CDK6, which accelerated the G1/S phase transition under hypoxia and enhanced sensitivity to 5-FU.	Fluorouracil	163-167	cyclin D1	Homo sapiens	51-59
27769069-11	2016	In conclusion, the data suggest that SPS-7 is not an immunosuppressant while induces anticancer effect against HRPC through inhibition of Akt/mTOR/p70S6K pathwaysthat down-regulate protein levels of both c-Myc and cyclin D1, leading to G1 arrest of cell cycle and subsequent apoptosis.	arginyl-threonyl-prolyl-prolyl-prolyl-seryl-glycine	37-42	cyclin D1	Homo sapiens	214-223
27681596-2	2016	We report the discovery of ML364, a small molecule inhibitor of the deubiquitinase USP2 and its use to interrogate the biology of USP2 and its putative substrate cyclin D1.	ML364	27-32	cyclin D1	Homo sapiens	162-171
27681596-5	2016	ML364 induced an increase in cellular cyclin D1 degradation and caused cell cycle arrest as shown in Western blottings and flow cytometry assays utilizing both Mino and HCT116 cancer cell lines.	ML364	0-5	cyclin D1	Homo sapiens	38-47
27904693-5	2016	Berberine also downregulated the expression of SP1, CCND1, and BCL2, determined with western blotting.	Berberine	0-9	cyclin D1	Homo sapiens	52-57
27904693-8	2016	Therefore, we conclude that berberine treatment suppresses cancer cell growth by regulating miR-22-3p and SP1 and its downstream targets, CCND1 and BCL2, in HCC.	Berberine	28-37	cyclin D1	Homo sapiens	138-143
27761814-8	2017	HDACi, such as Vorinostat (Suberoylanilide hydroxamic acid (SAHA)), affect cancer cells in part by suppressing the translation of key proteins linked to tumorigenesis, such as cyclin D1 and hypoxia inducible factor 1 alpha (HIF-1alpha).	Vorinostat	15-25	cyclin D1	Homo sapiens	176-185
27565221-9	2016	Ca-Asp also up-regulated the levels of caspase-3 and p53, but down regulated the level of cyclin D1, NF-kappaB, COX-2 and PGE2.	ca-asp	0-6	cyclin D1	Homo sapiens	90-99
27640746-6	2016	In consistent with this view, the expression of Wnt/beta-catenin signaling target genes including c-Myc, cyclin D1 and Axin2 in MCF-7 and MDA-MB-231 cells were suppressed after treatment with 5GTN.	5-acetyl goniothalamin	192-196	cyclin D1	Homo sapiens	105-114
27693124-10	2016	There were significant decreases in the expression levels of p53, p27, CDK4, cyclinD1 and PCNA in HSFs treated with rhEndostatin.	rhendostatin	116-128	cyclin D1	Homo sapiens	77-85
27693124-11	2016	In conclusion, rhEndostatin inhibited HSF proliferation via G0/G1 and/or G2/M phase arrest of the cell cycle, which was partially due to the down-regulation of cyclinD1, CDK4 and PCNA.	rhendostatin	15-27	cyclin D1	Homo sapiens	160-168
27854312-0	2016	Berberine Suppresses Cyclin D1 Expression through Proteasomal Degradation in Human Hepatoma Cells.	Berberine	0-9	cyclin D1	Homo sapiens	21-30
27854312-1	2016	The aim of this study is to explore the underlying mechanism on berberine-induced Cyclin D1 degradation in human hepatic carcinoma.	Berberine	64-73	cyclin D1	Homo sapiens	82-91
27854312-2	2016	We observed that berberine could suppress both in vitro and in vivo expression of Cyclin D1 in hepatoma cells.	Berberine	17-26	cyclin D1	Homo sapiens	82-91
27854312-3	2016	Berberine exhibits dose- and time-dependent inhibition on Cyclin D1 expression in human hepatoma cell HepG2.	Berberine	0-9	cyclin D1	Homo sapiens	58-67
27854312-4	2016	Berberine increases the phosphorylation of Cyclin D1 at Thr286 site and potentiates Cyclin D1 nuclear export to cytoplasm for proteasomal degradation.	Berberine	0-9	cyclin D1	Homo sapiens	43-52
27854312-4	2016	Berberine increases the phosphorylation of Cyclin D1 at Thr286 site and potentiates Cyclin D1 nuclear export to cytoplasm for proteasomal degradation.	Berberine	0-9	cyclin D1	Homo sapiens	84-93
27854312-5	2016	In addition, berberine recruits the Skp, Cullin, F-box containing complex-beta-Transducin Repeat Containing Protein (SCFbeta-TrCP) complex to facilitate Cyclin D1 ubiquitin-proteasome dependent proteolysis.	Berberine	13-22	cyclin D1	Homo sapiens	153-162
27854312-6	2016	Knockdown of beta-TrCP blocks Cyclin D1 turnover induced by berberine; blocking the protein degradation induced by berberine in HepG2 cells increases tumor cell resistance to berberine.	Berberine	60-69	cyclin D1	Homo sapiens	30-39
27738318-8	2016	The expressions of Bcl-xL and Cyclind1 proteins were decreased, whereas the levels of cleavage of poly-ADP ribose polymerase (PARP) were considerably increased in the cell lines in response to berberine treatment.	Berberine	193-202	cyclin D1	Homo sapiens	30-38
27799526-5	2016	In breast cancer MDA-MB-231 and MDA-MB-468 cells, nanomolar concentrations of prodigiosin decreased phosphorylation of LRP6, DVL2, and GSK3beta and suppressed beta-catenin-stimulated Wnt target gene expression, including expression of cyclin D1.	Prodigiosin	78-89	cyclin D1	Homo sapiens	235-244
27412172-7	2016	MG treatment also downregulated factors that are upstream of RB-E2F1 signaling such as Cdk2, Cyclin E, Cdk4, and Cyclin D1 where Cyclin D3 level was unaffected.	methyl gallate	0-2	cyclin D1	Homo sapiens	113-122
27821095-16	2016	Treatment with OZ513 increased apoptotic markers and glycolysis with a decline in the MYCN oncogene and the cell cycle regulator cyclinD1.	oz513	15-20	cyclin D1	Homo sapiens	129-137
27713153-0	2016	CCND1 mutations increase protein stability and promote ibrutinib resistance in mantle cell lymphoma.	ibrutinib	55-64	cyclin D1	Homo sapiens	0-5
27713153-5	2016	Mechanistically, these mutations stabilized CCND1 protein through attenuation of threonine-286 phosphorylation, which is important for proteolysis through the ubiquitin-proteasome pathway.	Threonine	81-90	cyclin D1	Homo sapiens	44-49
27713153-7	2016	Interestingly, forced expression of WT or mutant CCND1 increased resistance of MCL cell lines to ibrutinib, an FDA-approved Bruton tyrosine kinase inhibitor for MCL treatment.	ibrutinib	97-106	cyclin D1	Homo sapiens	49-54
27713153-9	2016	Furthermore, primary MCL tumors with CCND1 mutations also expressed stable CCND1 protein and were resistant to ibrutinib.	ibrutinib	111-120	cyclin D1	Homo sapiens	37-42
27713153-10	2016	These findings uncover a new mechanism that is critical for the regulation of CCND1 protein levels, and is directly relevant to primary ibrutinib resistance in MCL.	ibrutinib	136-145	cyclin D1	Homo sapiens	78-83
27824155-5	2016	Cucurbitacin D treatment of cervical cancer cells arrested the cell cycle in G1/S phase, inhibited constitutive expression of E6, Cyclin D1, CDK4, pRb, and Rb and induced the protein levels of p21 and p27.	cucurbitacin D	0-14	cyclin D1	Homo sapiens	130-139
27600289-6	2016	d-3-Deoxy-diC8PI also induces a decrease in endogenous levels of cyclins D1 and D3 and blocks downstream retinoblastoma protein phosphorylation.	3-deoxy-dioctanoylphosphatidylinositol	0-16	cyclin D1	Homo sapiens	65-82
27726305-6	2016	Solanine regulates the protein levels of cell cycle proteins, including Cyclin D1, Cyclin E1, CDK2, CDK4, CDK6, and P21 in vivo and in vitro.	Solanine	0-8	cyclin D1	Homo sapiens	72-81
27449706-6	2016	G1 phase cell cycle arrest and decreased expression of cyclin D1 and cyclin-dependent kinases 4 were also observed after STA treatment.	stephanthraniline A	121-124	cyclin D1	Homo sapiens	55-64
27826624-6	2016	Western blotting also confirmed that GMSCs could upregulate expression of pro-apoptotic genes including p-JNK, cleaved PARP, cleaved caspase-3, Bax expression and downregulate proliferation- and anti-apoptosis-related gene expression such as p-ERK1/2, Bcl-2, CDK4, cyclin D1, PCNA and survivin.	gmscs	37-42	cyclin D1	Homo sapiens	265-274
27748864-2	2016	The antitumor pharmacological effects of BA consist of triggering apoptosis via the mitochondrial pathway, regulating the cell cycle and the angiogenic pathway via factors, including specificity protein transcription factors, cyclin D1 and epidermal growth factor receptor, inhibiting the signal transducer and activator of transcription 3 and nuclear factor-kappaB signaling pathways, preventing the invasion and metastasis of tumor cells, and affecting the expression of topoisomerase I, p53 and lamin B1.	betulinic acid	41-43	cyclin D1	Homo sapiens	226-235
27546592-0	2016	Inorganic polyphosphate promotes cyclin D1 synthesis through activation of mTOR/Wnt/beta-catenin signaling in endothelial cells.	inorganic polyphosphate	0-23	cyclin D1	Homo sapiens	33-42
27546592-10	2016	Inhibitors of mTORC1 (PI3K, AKT, PLC, PKC), rapamycin and siRNA for raptor (mTORC1-specific component) and beta-catenin, all inhibited polyP-mediated regulation of cyclin D1 expression, phosphorylation and subcellular localization in endothelial cells.	Polyphosphates	135-140	cyclin D1	Homo sapiens	164-173
27633099-5	2016	Furthermore, the phosphorylation levels of ErbB2, ErbB3 and Akt and the protein levels of cyclin D1 were decreased by lapatinib treatment of HSC3, HSC4 and Ca9-22 cells.	Lapatinib	118-127	cyclin D1	Homo sapiens	90-99
27633795-8	2016	Regarding extratelomeric activities, our results showed a decrease of 64, 38 and 25% in the transcription of c-Myc, Cyc-D1 and TERT, respectively (p&lt;0.05) after AZT treatment.	Zidovudine	164-167	cyclin D1	Homo sapiens	116-122
27779188-6	2016	Moreover, flow cytometry analysis indicated that simvastatin induced cell cycle arrest at G0/G1 phase, suggested by downregulation of CDK4/6 and Cyclin D1.	Simvastatin	49-60	cyclin D1	Homo sapiens	145-154
27489231-5	2016	Consistently, obovatol cleaved PARP, activated caspase 9/3 and Bax and attenuated the expression of cyclin D1 in A549 and H460 NSCLCs.	obovatol	14-22	cyclin D1	Homo sapiens	100-109
27779188-8	2016	More importantly, we found that the cell cycle arrest at G0/G1 phase and the alterations of CDK4/6 and Cyclin D1 triggered by simvastatin could be recovered by PPARgamma-antagonist (GW9662), whereas the treatment of PPARalpha-antagonist (GW6471) shown no significant effects on the BCa cells.	Simvastatin	126-137	cyclin D1	Homo sapiens	103-112
27779188-8	2016	More importantly, we found that the cell cycle arrest at G0/G1 phase and the alterations of CDK4/6 and Cyclin D1 triggered by simvastatin could be recovered by PPARgamma-antagonist (GW9662), whereas the treatment of PPARalpha-antagonist (GW6471) shown no significant effects on the BCa cells.	2-chloro-5-nitrobenzanilide	182-188	cyclin D1	Homo sapiens	103-112
28090191-4	2016	Also, ursolic acid treatment accumulated the sub-G1 population, attenuated the expression of procapase 9, cyclin D1, pAKT, p-glycogen synthase kinase 3-alpha/beta (pGSK3alpha/beta), beta-catenin and nuclear factor kappa-light-chain-enhancer of activated B cells (NFkB) and also cleaved caspase 3 and poly (ADP-ribose) polymerase (PARP) in mesothelioma cells.	ursolic acid	6-18	cyclin D1	Homo sapiens	106-115
27735939-5	2016	We also found pectolinarigenin significantly suppressed osteosarcoma cell proliferation, induced apoptosis and reduced the level of STAT3 downstream proteins cyclin D1, Survivin, B-cell lymphoma 2 (Bcl-2), B-cell lymphoma extra-large (Bcl-xl) and myeloid cell leukemia 1 (Mcl-1).	pectolinarigenin	14-30	cyclin D1	Homo sapiens	158-167
27592552-6	2016	Consequently, MG treatment facilitated translocation of the stabilized beta-catenin from the cytoplasm to nucleus, and activates its target genes cyclin D1 and c-Myc.	methyl gallate	14-16	cyclin D1	Homo sapiens	146-155
27321870-10	2016	Moreover, we found that WISP1 overexpression stimulated GSK3alpha/beta phosphorylation, and increased expression of cyclin D1 and MMP9 in human VSMCs, and this effect was abolished by AZD5363.	capivasertib	184-191	cyclin D1	Homo sapiens	116-125
27798882-0	2016	The Significant Role of Cyclin D1 in the Synergistic Growth-inhibitory Effect of Combined Therapy of Vandetanib with 5-Fluorouracil for Gastric Cancer.	vandetanib	101-111	cyclin D1	Homo sapiens	24-33
27798882-0	2016	The Significant Role of Cyclin D1 in the Synergistic Growth-inhibitory Effect of Combined Therapy of Vandetanib with 5-Fluorouracil for Gastric Cancer.	Fluorouracil	117-131	cyclin D1	Homo sapiens	24-33
27798882-11	2016	The level of expression of cyclin D1 was clearly strong in MKN7 and MKN74 in the natural state, and the expression of cyclin D1, E2 promoter binding factor 1 and thymidylate synthase (TYMS) was inhibited by vandetanib, but not in MKN1 cells.	vandetanib	207-217	cyclin D1	Homo sapiens	27-36
27798882-11	2016	The level of expression of cyclin D1 was clearly strong in MKN7 and MKN74 in the natural state, and the expression of cyclin D1, E2 promoter binding factor 1 and thymidylate synthase (TYMS) was inhibited by vandetanib, but not in MKN1 cells.	vandetanib	207-217	cyclin D1	Homo sapiens	118-127
27798882-13	2016	CONCLUSION: The synergistic effect of vandetanib with 5-FU is related to vandetanib-induced reduction of TYMS via down-regulation of cyclin D1.	vandetanib	38-48	cyclin D1	Homo sapiens	133-142
27798882-13	2016	CONCLUSION: The synergistic effect of vandetanib with 5-FU is related to vandetanib-induced reduction of TYMS via down-regulation of cyclin D1.	Fluorouracil	54-58	cyclin D1	Homo sapiens	133-142
27798882-13	2016	CONCLUSION: The synergistic effect of vandetanib with 5-FU is related to vandetanib-induced reduction of TYMS via down-regulation of cyclin D1.	vandetanib	73-83	cyclin D1	Homo sapiens	133-142
27520485-7	2016	At the molecular level, the expression of several key TPA-induced pro-survival and pro-proliferative genes (Bcl2, Cyclin D1, and c-Myc) decreased rapidly after BET inhibition.	Tetradecanoylphorbol Acetate	54-57	cyclin D1	Homo sapiens	114-123
27287014-6	2016	In contrast, genes involved in promoting adipogenesis such as LEP, FGF1, CCND1, and SREBF1 were significantly down-regulated by hydroxytyrosol treatment.	3,4-dihydroxyphenylethanol	128-142	cyclin D1	Homo sapiens	73-78
27698776-7	2016	Cucurbitacin B treatment significantly suppressed the expression of cyclin D1, cyclin E, cyclin-dependent kinase 4 (CDK4) and CDK2, while increasing the expression of p27.	cucurbitacin B	0-14	cyclin D1	Homo sapiens	68-77
27831653-8	2016	RESULTS: Our results demonstrated that cisplatin could inhibit the expression of CCND1 in human epithelial ovarian cancer cell line, which is related to the decreased cell proliferation and increased cell apoptosis.	Cisplatin	39-48	cyclin D1	Homo sapiens	81-86
27198552-6	2016	Combination of carmustine and selenite treatment significantly increased reactive oxygen species, apoptosis and growth inhibition in CRPC cells with down regulation of anti-apoptotic (Bcl-2 and Mcl-1) and proliferative proteins (c-Myc and cyclin-D1).	Carmustine	15-25	cyclin D1	Homo sapiens	239-248
27198552-6	2016	Combination of carmustine and selenite treatment significantly increased reactive oxygen species, apoptosis and growth inhibition in CRPC cells with down regulation of anti-apoptotic (Bcl-2 and Mcl-1) and proliferative proteins (c-Myc and cyclin-D1).	Selenious Acid	30-38	cyclin D1	Homo sapiens	239-248
27464528-5	2016	Indigocarpan induces p53-dependent p21 upregulation and apoptosis in LS174T cells, upregulates p53 and p21(WAF1) protein levels, enhances cleavage of caspase-3 and downregulates cyclin D1, cyclin B1 and PCNA protein levels, indicating its role in modulating cell cycle progression.	Indigocarpan	0-12	cyclin D1	Homo sapiens	178-187
27574028-6	2016	Through western blotting, immunofluorescence and a luciferase assay, it was identified that reduced cyclin D1/Akt1/wingless type MMTV integration site family member 1 (Wnt1) signaling activity accounts for the let-7-induced radiation sensitization.	let-7	210-215	cyclin D1	Homo sapiens	100-109
27574028-7	2016	Let-7 directly inhibits cyclin D1 expression, resulting in low phosphorylation of Akt1, which is critical for the let-7-induced inhibition of mammosphere numbers.	let-7	0-5	cyclin D1	Homo sapiens	24-33
27574028-7	2016	Let-7 directly inhibits cyclin D1 expression, resulting in low phosphorylation of Akt1, which is critical for the let-7-induced inhibition of mammosphere numbers.	let-7	114-119	cyclin D1	Homo sapiens	24-33
27599556-7	2016	Heparin also decreased the TNF-alpha-induced mRNA and protein expression levels of IL-6, IL-8, TNF-alpha and cyclin D1 in a dose-dependent manner.	Heparin	0-7	cyclin D1	Homo sapiens	109-118
27599556-10	2016	In conclusion, the results of the present study revealed that heparin inhibited the TNF-alpha-induced proliferation, cytokine production, expression of cyclin D1 and activation of NF-kappaB signaling in FLSs, indicating the therapeutic potential of heparin in the treatment of RA.	Heparin	62-69	cyclin D1	Homo sapiens	152-161
27599556-10	2016	In conclusion, the results of the present study revealed that heparin inhibited the TNF-alpha-induced proliferation, cytokine production, expression of cyclin D1 and activation of NF-kappaB signaling in FLSs, indicating the therapeutic potential of heparin in the treatment of RA.	Heparin	249-256	cyclin D1	Homo sapiens	152-161
27698879-8	2016	Furthermore, GSL suppressed Gli-mediated transcriptional activity in human pancreatic cancer PANC-1 and AsPC-1 cells, which resulted in reduced cancer cell proliferation and downregulated expression of the Gli-target genes, Gli1 and cyclin D1.	GalA-GSL	13-16	cyclin D1	Homo sapiens	233-242
27499090-7	2016	Mechanistically, western blot analysis indicated that Sch B induced apoptosis by upregulating Bax, cleaved caspase-3, cleaved caspase-9 and cleaved PARP, and by downregulating cyclin D1, Bcl-2 and CDK-4.	schizandrin B	54-59	cyclin D1	Homo sapiens	176-185
27657916-3	2016	In this work we have demonstrated that physiological concentrations of caffeine reduce the proliferation rate of H460 cells: along with the modulation of p53, pAKT and Cyclin D1, caffeine also determines a significant FHC up-regulation through the activation of its transcriptional efficiency.	Caffeine	71-79	cyclin D1	Homo sapiens	168-177
27495233-9	2016	Furthermore, miRNA-363 inhibition induced the downregulation of AKT, cyclin-D1, matrix metalloproteinase (MMP)-2, MMP-9, and Bcl-2 and upregulation of caspase 3.	mirna-363	13-22	cyclin D1	Homo sapiens	69-78
27766950-8	2016	Molecular docking analyses were performed to check the potential of two natural inhibitors, rutin and curcumin to bind CCND1.	Rutin	92-97	cyclin D1	Homo sapiens	119-124
27766950-8	2016	Molecular docking analyses were performed to check the potential of two natural inhibitors, rutin and curcumin to bind CCND1.	Curcumin	102-110	cyclin D1	Homo sapiens	119-124
27766950-13	2016	The ligands - rutin and curcumin bounded with CCND1 with good affinity.	Rutin	14-19	cyclin D1	Homo sapiens	46-51
27766950-13	2016	The ligands - rutin and curcumin bounded with CCND1 with good affinity.	Curcumin	24-32	cyclin D1	Homo sapiens	46-51
27670681-10	2016	In cyclin D1 degradation, we found that T286 of cyclin D1 play a pivotal role in PF-mediated cyclin D1 degradation.	C.I. Basic Blue 54	40-44	cyclin D1	Homo sapiens	3-12
27670681-10	2016	In cyclin D1 degradation, we found that T286 of cyclin D1 play a pivotal role in PF-mediated cyclin D1 degradation.	C.I. Basic Blue 54	40-44	cyclin D1	Homo sapiens	48-57
27670681-10	2016	In cyclin D1 degradation, we found that T286 of cyclin D1 play a pivotal role in PF-mediated cyclin D1 degradation.	C.I. Basic Blue 54	40-44	cyclin D1	Homo sapiens	48-57
27654866-9	2016	Furthermore, western blot showed that bicyclol inhibited phosphorylation of Akt and ERK, down-regulated the expressions of cyclin D1, cyclin E2, CDK2, CDK4, p-Rb and p-mTOR.	bicyclol	38-46	cyclin D1	Homo sapiens	123-132
27542271-10	2016	In addition, the induction of alterations in quantity of c-Myc, Bcl-2, Bax, cyclinD1 and Akt-p molecules in HepG2 cells by LAPTM4B-35 overexpression could be reversed by ETS.	ets	170-173	cyclin D1	Homo sapiens	76-84
27624480-8	2016	Furthermore, the combination of atorvastatin and C3G modulated the PI3K/Akt pathway and upregulated p21Cip1, which was associated with decreases in cyclin D1 and phospho-retinoblastoma expressions.	Atorvastatin	32-44	cyclin D1	Homo sapiens	148-157
27596272-0	2016	Tylophorine Analog DCB-3503 Inhibited Cyclin D1 Translation through Allosteric Regulation of Heat Shock Cognate Protein 70.	tylophorine	0-11	cyclin D1	Homo sapiens	38-47
27596272-1	2016	Tylophorine analog DCB-3503 is a potential anticancer and immunosuppressive agent that suppresses the translation of cellular regulatory proteins, including cyclin D1, at the elongation step.	tylophorine	0-11	cyclin D1	Homo sapiens	157-166
27596272-0	2016	Tylophorine Analog DCB-3503 Inhibited Cyclin D1 Translation through Allosteric Regulation of Heat Shock Cognate Protein 70.	DCB 3503	19-27	cyclin D1	Homo sapiens	38-47
27596272-1	2016	Tylophorine analog DCB-3503 is a potential anticancer and immunosuppressive agent that suppresses the translation of cellular regulatory proteins, including cyclin D1, at the elongation step.	DCB 3503	19-27	cyclin D1	Homo sapiens	157-166
27596272-4	2016	DCB-3503 allosterically regulates the ATPase and chaperone activities of HSC70 by promoting ATP hydrolysis in the presence of specific RNA binding motifs (AUUUA) of cyclin D1 mRNA.	dcb	0-3	cyclin D1	Homo sapiens	165-174
27596272-5	2016	The suppression of cyclin D1 translation by DCB-3503 is not solely caused by perturbation of the homeostasis of microRNAs, although the microRNA processing complex is dissociated with DCB-3503 treatment.	DCB 3503	44-52	cyclin D1	Homo sapiens	19-28
27596272-5	2016	The suppression of cyclin D1 translation by DCB-3503 is not solely caused by perturbation of the homeostasis of microRNAs, although the microRNA processing complex is dissociated with DCB-3503 treatment.	DCB 3503	184-192	cyclin D1	Homo sapiens	19-28
27596272-7	2016	DCB-3503 may be used to treat malignancies, such as hepatocellular carcinoma or breast cancer with elevated expression of cyclin D1.	DCB 3503	0-8	cyclin D1	Homo sapiens	122-131
27424123-0	2016	The coffee diterpene kahweol suppresses the cell proliferation by inducing cyclin D1 proteasomal degradation via ERK1/2, JNK and GKS3beta-dependent threonine-286 phosphorylation in human colorectal cancer cells.	Diterpenes	11-20	cyclin D1	Homo sapiens	75-84
27181679-8	2016	Importantly, the MEK1 inhibitor PD98059, like MEK1 silencing, induced an augment of cyclin D1 expression that correlated with an increase of MDA-MB-231 cell proliferation suggesting that MEK1 may play a regulatory role in these cells.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	32-39	cyclin D1	Homo sapiens	84-93
27424123-0	2016	The coffee diterpene kahweol suppresses the cell proliferation by inducing cyclin D1 proteasomal degradation via ERK1/2, JNK and GKS3beta-dependent threonine-286 phosphorylation in human colorectal cancer cells.	kahweol	21-28	cyclin D1	Homo sapiens	75-84
27424123-0	2016	The coffee diterpene kahweol suppresses the cell proliferation by inducing cyclin D1 proteasomal degradation via ERK1/2, JNK and GKS3beta-dependent threonine-286 phosphorylation in human colorectal cancer cells.	Threonine	148-157	cyclin D1	Homo sapiens	75-84
27424123-7	2016	MG132 treatment attenuated kahweol-mediated cyclin D1 downregulation and the half-life of cyclin D1 was decreased in kahweol-treated cells.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	0-5	cyclin D1	Homo sapiens	44-53
27424123-7	2016	MG132 treatment attenuated kahweol-mediated cyclin D1 downregulation and the half-life of cyclin D1 was decreased in kahweol-treated cells.	kahweol	27-34	cyclin D1	Homo sapiens	44-53
27424123-7	2016	MG132 treatment attenuated kahweol-mediated cyclin D1 downregulation and the half-life of cyclin D1 was decreased in kahweol-treated cells.	kahweol	117-124	cyclin D1	Homo sapiens	90-99
27424123-8	2016	Kahweol increased phosphorylation of cyclin D1 at threonine-286 and a point mutation of threonine-286 to alanine attenuated cyclin D1 degradation by kahweol.	kahweol	0-7	cyclin D1	Homo sapiens	37-46
27424123-8	2016	Kahweol increased phosphorylation of cyclin D1 at threonine-286 and a point mutation of threonine-286 to alanine attenuated cyclin D1 degradation by kahweol.	Threonine	50-59	cyclin D1	Homo sapiens	37-46
27424123-8	2016	Kahweol increased phosphorylation of cyclin D1 at threonine-286 and a point mutation of threonine-286 to alanine attenuated cyclin D1 degradation by kahweol.	kahweol	149-156	cyclin D1	Homo sapiens	124-133
27424123-9	2016	Inhibition of ERK1/2 by PD98059, JNK by SP600125 or GSK3beta by LiCl suppressed cyclin D1 phosphorylation and downregulation by kahweol.	pyrazolanthrone	40-48	cyclin D1	Homo sapiens	80-89
27424123-10	2016	Furthermore, the inhibition of nuclear export by LMB attenuated cyclin D1 degradation by kahweol.	leptomycin B	49-52	cyclin D1	Homo sapiens	64-73
27424123-11	2016	In conclusion, kahweol-mediated cyclin D1 degradation may contribute to the inhibition of the proliferation in human colorectal cancer cells.	kahweol	15-22	cyclin D1	Homo sapiens	32-41
27500741-5	2016	Quantitative PCR analysis demonstrated that CIMO decreases the relative mRNA expression of genes that are involved in cell cycle progression (CCND1) and cell survival (BCL2, BCL-xL, BAD, CASP 3/7/9, and TP53).	cimo	44-48	cyclin D1	Homo sapiens	142-147
27432558-6	2016	Propranolol treatment inhibited growth and induced apoptosis of 8505C cells in vitro and in vivo, which are closely associated with decreased expressions of cyclin D1 and anti-apoptotic Bcl-2.	Propranolol	0-11	cyclin D1	Homo sapiens	157-166
27573873-8	2016	The blocking of cell cycle progression by VC-A was associated with the inhibition of cell cycle regulatory proteins cyclin D1, cyclin E, cyclin-dependent kinases (cdks) cdk2, cdk4 and cdk inhibitor WAF1/21.	muconomycin A	42-46	cyclin D1	Homo sapiens	116-125
27491559-5	2016	We also found that neo-tanshinlactone decreased steady state ESR1 mRNA levels in ER+ breast cancer cells, which was further confirmed by analysis of ER protein levels as well as the mRNA levels of target genes of this transcription factor, such as ESR2, BRCA1, CCND1, GREB1, TFF1, SERPINB9 and ABCA3.	neotanshinlactone	19-37	cyclin D1	Homo sapiens	261-266
27474499-6	2016	We also detected the expression and activities of cell-cycle positive regulators (cyclin D1, cyclin E, CDK2, CDK4 and CDK6) and negative regulators (p21 and p27) in human PASMCs by western blots and co-immuoprecipitation (IP).	pasmcs	171-177	cyclin D1	Homo sapiens	82-91
27447743-3	2016	SAHA induced the overexpression of acetyl histone 3 and 4, which were recruited to p21, p27, Cyclin D1, c-myc and nanog promoters to transcriptionally up-regulate the former two and down-regulate the latter three.	acetyl histone	35-49	cyclin D1	Homo sapiens	93-102
27589737-6	2016	Iron chelators enhanced expressions of NDRG1 and NDRG3 while repressing cyclin D1 expression in OSCC cells.	Iron	0-4	cyclin D1	Homo sapiens	72-81
27312872-6	2016	The protein level assays revealed that TCDD increased cyclin-dependent kinases 4 (cdk4), cyclin D1, cyclin E and p21 (Waf1/Cip1) but not cdk2, bcl-2, cyclin B1 and cyclin A.	Polychlorinated Dibenzodioxins	39-43	cyclin D1	Homo sapiens	89-98
27515956-5	2016	Our model analysis revealed an ultrasensitive mechanism of cyclin D1 degradation that controls the glioma differentiation induced by the cAMP inducer cholera toxin (CT).	Cyclic AMP	137-141	cyclin D1	Homo sapiens	59-68
27525972-8	2016	Nevertheless, 3MCIC inhibited the Wnt/beta-catenin pathway by downregulating beta-catenin, c-Myc, cyclin D1 and E2F1.	3mcic	14-19	cyclin D1	Homo sapiens	98-107
27506388-7	2016	RSV-GSE, but not sulindac, suppressed downstream protein levels of Wnt/beta-catenin pathway, c-Myc and cyclin D1.	Resveratrol	0-3	cyclin D1	Homo sapiens	103-112
27648364-8	2016	We evaluated the cell killing effect of combined rapamycin and cisplatin treatment and showed that the combination had a more than additive effect in both androgen dependent and independent prostate cancer cells, which may be partially explained by the reduction of cyclin D1 expression by rapamycin.	Sirolimus	49-58	cyclin D1	Homo sapiens	266-275
27490694-5	2016	Specific inhibition of AP-1 by the retinoid SR 11302 counteracted the cytotoxic effects induced by GCDCA while promoting NOS-3 expression recovery and cyclin D1 reduction.	Retinoids	35-43	cyclin D1	Homo sapiens	151-160
27490694-8	2016	Our data provide direct evidence for the involvement of AP-1 in the NOS-3 expression regulation during cholestasis and define a critical role for NOS-3 in regulating the expression of cyclin D1 during the cell damage induced by bile acids.	Bile Acids and Salts	228-238	cyclin D1	Homo sapiens	184-193
27648364-7	2016	We determined the expression of cyclin D1 and phosphorylated-mTOR proteins in association with the response to rapamycin in two androgen sensitive (22RV1 and LNCaP) and two androgen independent (DU145 and PC3) prostate cancer cell lines and found that the base-line and changes of cyclin D1 level, but not the expression level of p-mTOR, correlated with rapamycin sensitivity.	Sirolimus	111-120	cyclin D1	Homo sapiens	32-41
25894100-9	2016	In addition, Cyclin D1 protein expression levels were decreased by second- and third-generation BP treatment.	Diphosphonates	96-98	cyclin D1	Homo sapiens	13-22
27087167-11	2016	In addition, treatment with PLX4032 significantly decreased proliferation in both stromal and epithelial cells with a concomitant decrease in Cyclin D1/CDK4 complex and PTGS2 levels.	Vemurafenib	28-35	cyclin D1	Homo sapiens	142-151
27045402-1	2016	In the present study, our aim was to assess the incidence of BCL-1 gene rearrangements in formalin-fixed paraffin embedded (FFPE) tissue in patients with non-Hodgkin lymphomas (NHL).	Formaldehyde	90-98	cyclin D1	Homo sapiens	61-66
27045402-1	2016	In the present study, our aim was to assess the incidence of BCL-1 gene rearrangements in formalin-fixed paraffin embedded (FFPE) tissue in patients with non-Hodgkin lymphomas (NHL).	Paraffin	105-113	cyclin D1	Homo sapiens	61-66
27094504-9	2016	Also, treatment with honokiol and rosiglitazone induced cell cycle arrest in the G0/G1 phase; increased p21; and decreased cyclin D1, cyclin E1, and Rb expression in SK-Hep1 hepatoma cells.	honokiol	21-29	cyclin D1	Homo sapiens	123-132
27094504-9	2016	Also, treatment with honokiol and rosiglitazone induced cell cycle arrest in the G0/G1 phase; increased p21; and decreased cyclin D1, cyclin E1, and Rb expression in SK-Hep1 hepatoma cells.	Rosiglitazone	34-47	cyclin D1	Homo sapiens	123-132
27094504-10	2016	CONCLUSION: Honokiol combined with rosiglitazone showed more effective growth inhibition in hepatoma cells mediated through the regulation of G0/G1 phase-related proteins p21, cyclin D1, cyclin E1, and Rb and cell cycle progression.	honokiol	12-20	cyclin D1	Homo sapiens	176-185
27094504-10	2016	CONCLUSION: Honokiol combined with rosiglitazone showed more effective growth inhibition in hepatoma cells mediated through the regulation of G0/G1 phase-related proteins p21, cyclin D1, cyclin E1, and Rb and cell cycle progression.	Rosiglitazone	35-48	cyclin D1	Homo sapiens	176-185
26671528-9	2016	In addition, GW9662 and PPARgamma-siRNA pretreatment also significantly attenuated the downregulation of the cell cycle control protein cyclin D1 and the upregulation of cyclin-dependent kinase inhibitor p21 induced by evodiamine.	2-chloro-5-nitrobenzanilide	13-19	cyclin D1	Homo sapiens	136-145
27648364-8	2016	We evaluated the cell killing effect of combined rapamycin and cisplatin treatment and showed that the combination had a more than additive effect in both androgen dependent and independent prostate cancer cells, which may be partially explained by the reduction of cyclin D1 expression by rapamycin.	Cisplatin	63-72	cyclin D1	Homo sapiens	266-275
27648364-8	2016	We evaluated the cell killing effect of combined rapamycin and cisplatin treatment and showed that the combination had a more than additive effect in both androgen dependent and independent prostate cancer cells, which may be partially explained by the reduction of cyclin D1 expression by rapamycin.	Sirolimus	290-299	cyclin D1	Homo sapiens	266-275
27477809-8	2016	Furthermore, sodium selenite increased the expression level of SBP1 and decreased the levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and the Wnt pathway components and its downstream targets, including beta-catenin, GSK-3beta, c-myc and cyclinD1 in these cell lines.	Sodium Selenite	13-28	cyclin D1	Homo sapiens	251-259
27071802-5	2016	Western blot analysis showed that cyclin D1, cyclin B1, and cyclin E were upregulated in Cd-treated cells.	Cadmium	89-91	cyclin D1	Homo sapiens	34-43
27071802-7	2016	Silencing of HMGA2 gene by siRNA blocked Cd-induced cyclin D1, cyclin B1, and cyclin E expression and reduction of the number of G0/G1 phase cells.	Cadmium	41-43	cyclin D1	Homo sapiens	52-61
27351284-6	2016	In liver and breast cancer cells, knockdown of cyclin D1 leads to increased PPARalpha transcriptional activity, expression of PPARalpha target genes, and fatty acid oxidation.	Fatty Acids	154-164	cyclin D1	Homo sapiens	47-56
27351284-0	2016	Cyclin D1 represses peroxisome proliferator-activated receptor alpha and inhibits fatty acid oxidation.	Fatty Acids	82-92	cyclin D1	Homo sapiens	0-9
27351284-9	2016	Cyclin D1 expression is both necessary and sufficient for growth factor-mediated repression of fatty acid oxidation in proliferating hepatocytes.	Fatty Acids	95-105	cyclin D1	Homo sapiens	0-9
27351284-4	2016	In this study, we find that cyclin D1 inhibits the activity of a key metabolic transcription factor, peroxisome proliferator-activated receptor alpha (PPARalpha), a member of nuclear receptor family that induces fatty acid oxidation and may play an anti-neoplastic role.	Fatty Acids	212-222	cyclin D1	Homo sapiens	28-37
27351284-10	2016	These studies indicate that in addition to playing a pivotal role in cell cycle progression, cyclin D1 represses PPARalpha activity and inhibits fatty acid oxidation.	Fatty Acids	145-155	cyclin D1	Homo sapiens	93-102
27453171-10	2016	Thioridazine and irradiation treatment induced G0/G1 phases cell cycle arrest through down-regulation of CDK4 and cyclinD1.	Thioridazine	0-12	cyclin D1	Homo sapiens	114-122
27286258-7	2016	Both control and cyclin D1-expressing cells were more resistant to acute carfilzomib treatment when cultured on stromal cells than in suspension.	carfilzomib	73-84	cyclin D1	Homo sapiens	17-26
27286258-8	2016	However, this resistance was specifically reduced in cyclin D1-expressing cells after pomalidomide pre-treatment that modifies tumor cell/microenvironment interactions.	pomalidomide	86-98	cyclin D1	Homo sapiens	53-62
27286258-10	2016	We also found that cyclin D1 expression disrupted the redox balance by producing reactive oxygen species.	Reactive Oxygen Species	81-104	cyclin D1	Homo sapiens	19-28
27215381-5	2016	Calpain knockdown was associated with increased 17AAG-induced degradation of the HSP90 clients cyclin D1 and AKT and multidrug resistance protein 2, which correlated with increased expression of antimitogenic p27(KIP1) and proapoptotic BIM proteins.	tanespimycin	48-53	cyclin D1	Homo sapiens	95-104
27421652-8	2016	The inhibitory effect of everolimus was due to G1 arrest as a result of downregulation of cyclin D1 and p21.	Everolimus	25-35	cyclin D1	Homo sapiens	90-99
27237096-6	2016	Furthermore, the pro-proliferative effect of HA and up-regulated expression of Wnt/beta-catenin pathway-associated proteins - wnt3a, beta-catenin and cyclin D1 in hAMSCs were significantly inhibited upon pre-treatment with Wnt-C59, an inhibitor of the Wnt/beta-catenin pathway.	2-(4-(2-methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide	223-230	cyclin D1	Homo sapiens	150-159
27265745-0	2016	Erratum to "Down-regulation of hTERT and Cyclin D1 transcription via PI3K/Akt and TGF-beta pathways in MCF-7 cancer cells with PX-866 and Raloxifene" [Exp.	Raloxifene Hydrochloride	138-148	cyclin D1	Homo sapiens	41-50
27259268-5	2016	(-)-Oleocanthal also reduced STAT3 nuclear translocation and DNA binding activity, ultimately downregulating its downstream effectors, including the cell cycle protein Cyclin D1, the anti-apoptotic proteins Bcl-2 and survivin, and the invasion-related protein MMP 2.	oleocanthal	0-15	cyclin D1	Homo sapiens	168-177
27262990-4	2016	In Western blot assay, the protein expression of cell cycle related genes, cyclin D1 &amp; E1, was decreased by FA, Bz, and IP, which corresponded to their inhibitory effect on cell viability.	Benzene	116-118	cyclin D1	Homo sapiens	75-84
29441916-5	2016	Treatment of SMMC-7721 cells with oleanolic acid derivatives led to the downregulation of the mRNA and protein levels of beta-catenin, c-myc, and cyclin D1.	smmc	13-17	cyclin D1	Homo sapiens	146-155
29441916-5	2016	Treatment of SMMC-7721 cells with oleanolic acid derivatives led to the downregulation of the mRNA and protein levels of beta-catenin, c-myc, and cyclin D1.	Oleanolic Acid	34-48	cyclin D1	Homo sapiens	146-155
27068260-2	2016	In previous study, we reported that silymarin induces cyclin D1 proteasomal degradation through NF-kappaB-mediated threonine-286 phosphorylation.	Silymarin	36-45	cyclin D1	Homo sapiens	54-63
27068260-2	2016	In previous study, we reported that silymarin induces cyclin D1 proteasomal degradation through NF-kappaB-mediated threonine-286 phosphorylation.	Threonine	115-124	cyclin D1	Homo sapiens	54-63
27262990-9	2016	Taken together, these results showed that CS components, i.e., FA, Bz, and IP, inhibited the cell viability of SW620 cells by down-regulating the protein expression of cyclin D1 &amp; E1 and induced apoptosis of SW620 cells by increasing ROS production and simultaneously activating ER-stress.	Cesium	42-44	cyclin D1	Homo sapiens	168-177
27262990-9	2016	Taken together, these results showed that CS components, i.e., FA, Bz, and IP, inhibited the cell viability of SW620 cells by down-regulating the protein expression of cyclin D1 &amp; E1 and induced apoptosis of SW620 cells by increasing ROS production and simultaneously activating ER-stress.	Adenosine Monophosphate	179-182	cyclin D1	Homo sapiens	168-177
27262990-9	2016	Taken together, these results showed that CS components, i.e., FA, Bz, and IP, inhibited the cell viability of SW620 cells by down-regulating the protein expression of cyclin D1 &amp; E1 and induced apoptosis of SW620 cells by increasing ROS production and simultaneously activating ER-stress.	Reactive Oxygen Species	238-241	cyclin D1	Homo sapiens	168-177
27050122-0	2016	Some GCR Polymorphisms (N363S, ER22/23EK, and Bcl-1) May Influence Steroid-induced Toxicities and Survival Rates in Children With ALL.	Steroids	67-74	cyclin D1	Homo sapiens	46-51
27347174-0	2016	Quercetin reduces cyclin D1 activity and induces G1 phase arrest in HepG2 cells.	Quercetin	0-9	cyclin D1	Homo sapiens	18-27
27347121-6	2016	In AsPC-1 cells, the levels of cyclin D1 and phosphorylated retinoblastoma protein decreased following treatment with arsenite, but this was not observed in BxPC-3 cells.	arsenite	118-126	cyclin D1	Homo sapiens	31-40
27122002-6	2016	These results demonstrated that myricetin suppressed the cell viability of human breast cancer MCF-7 cells through PAK1/MEK/ERK/GSK3beta/beta-catenin/cyclin D1/PCNA/survivin/Bax-caspase-3 signaling.	myricetin	32-41	cyclin D1	Homo sapiens	150-159
27347174-12	2016	Based on the aforementioned observations, it is suggested that quercetin exerts antitumor activity in HepG2 cells through multiple pathways, including interfering with CCND1 gene expression to disrupt the cell cycle and proliferation of HepG2 cells.	Quercetin	63-72	cyclin D1	Homo sapiens	168-173
27347203-5	2016	The expression levels of STAT3 [total, tyrosine phosphorylated (p-Tyr) and serine phosphorylated (p-Ser)], JNK, c-Jun and cyclin D1 were assessed in the OSCC cell lines SCC25 and SCC9.	Phosphorus	6-7	cyclin D1	Homo sapiens	122-131
27347203-8	2016	Inhibition of JNK1/2 with either SP600125 treatment or specific siRNA silencing resulted in decreased levels of p-Ser STAT3 and increased levels of p-Tyr STAT3 and cyclin D1 in both cell lines.	pyrazolanthrone	33-41	cyclin D1	Homo sapiens	164-173
27445486-14	2016	Furthermore, AK126698 could inhibit the activation of Wnt/beta-catenin pathway, which was demonstrated by measuring the expression levels of Axin1, beta-catenin, c-myc, cyclin D1, and E-cadherin.	ak126698	13-21	cyclin D1	Homo sapiens	169-178
26980915-10	2016	Patients positive for cMet (P = .007), cyclin D1 (P = .019), and p16 (P = .004) had worse DSS.	dss	90-93	cyclin D1	Homo sapiens	39-48
27268017-8	2016	In vitro analysis showed that JNK inhibition by SP600125 in SNU-638 cells decreased cyclin D1 protein expression and increased FOXO1 activation.	pyrazolanthrone	48-56	cyclin D1	Homo sapiens	84-93
27347927-6	2016	In the mechanism study, cyanidin-3-O-glucoside chloride increased the ratio of cell cycle at G0/G1 phase and reduced cyclin D1 expression on Caco-2 cells.	asterin	24-55	cyclin D1	Homo sapiens	117-126
28881576-6	2017	LY294002-treated CCSCs showed decreases in proliferation, sphere formation and self-renewal, in phosphorylation-dependent activation of Akt, and in expression of cyclin D1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	cyclin D1	Homo sapiens	162-171
26104856-5	2016	Wogonoside promotes the expression of GATA-1 and facilitates the binding to methyl ethyl ketone (MEK) and p21 promoter, thus inhibiting MEK/extracellular signal-regulated kinase signaling and cell cycle checkpoint proteins, including CDK2, CDK4, cyclin A, and cyclin D1, and increasing p21 expression.	wogonoside	0-10	cyclin D1	Homo sapiens	260-269
27078622-0	2016	Mitochondrial reactive oxygen species-mediated genomic instability in low-dose irradiated human cells through nuclear retention of cyclin D1.	Reactive Oxygen Species	14-37	cyclin D1	Homo sapiens	131-140
27078622-7	2016	Excess mitochondrial ROS perturb AKT/cyclin D1 cell cycle signaling via oxidative inactivation of protein phosphatase 2A after low-dose long-term FR.	Reactive Oxygen Species	21-24	cyclin D1	Homo sapiens	37-46
27082017-7	2016	Results indicated that curcumin decreased expression of EMT-related genes in Tumor2 cell line when compared to its counterpart as E-cadherin, N-cadherin, ZEB2, Twist1, Slug, Axl, vimentin, STAT-3, fibronectin; and genes p53 and caveolin-1, as well as apoptotic genes caspase-3, caspase-8, and others such as cyclin D1 and NFkappaB.	Curcumin	23-31	cyclin D1	Homo sapiens	308-317
27390740-6	2016	Moreover, treatment with delphinidin inhibited the nuclear translocation of beta-catenin and the expression of beta-catenin target genes such as cyclin D1, c-myc, Axin-2, and T cell factor-1.	delphinidin	25-36	cyclin D1	Homo sapiens	145-154
27035641-0	2016	The effect of sulforaphane on the cell cycle, apoptosis and expression of cyclin D1 and p21 in the A549 non-small cell lung cancer cell line.	sulforaphane	14-26	cyclin D1	Homo sapiens	74-83
27035641-7	2016	siRNA was used to evaluate the role of cyclin D1 in the process of suforaphane-induced cell death.	suforaphane	67-78	cyclin D1	Homo sapiens	39-48
27035641-8	2016	We found that the percentage of cyclin D1-positive cells decreased after the treatment with SFN, but at the same time mean fluorescence intensity reflecting cyclin D1 content was increased at 30 microM SFN and decreased at 60 and 90 microM SFN.	sulforaphane	92-95	cyclin D1	Homo sapiens	32-41
27320892-8	2016	Lycorine up-regulated the mRNA levels of CDK4, Bax, caspase-3 while down-regulated the levels of survivin, Bcl-2 and Cyclin D1; the protein levels of CDK4 and Bax were increased and cyclin D1, Bcl-2 and surviving expressions were decreased, but caspase-3 expression showed no significant changes following the treatment.	lycorine	0-8	cyclin D1	Homo sapiens	117-126
26681767-0	2016	Isorhapontigenin suppresses growth of patient-derived glioblastoma spheres through regulating miR-145/SOX2/cyclin D1 axis.	isorhapontigenin	0-16	cyclin D1	Homo sapiens	107-116
27320892-8	2016	Lycorine up-regulated the mRNA levels of CDK4, Bax, caspase-3 while down-regulated the levels of survivin, Bcl-2 and Cyclin D1; the protein levels of CDK4 and Bax were increased and cyclin D1, Bcl-2 and surviving expressions were decreased, but caspase-3 expression showed no significant changes following the treatment.	lycorine	0-8	cyclin D1	Homo sapiens	182-191
26607678-5	2016	In serum-starved and re-feeding models of U251 and U373MG, we observed the rising expression of nucleostemin and p-beta-Catenin (p-Tyr645) were accompanied with cell proliferation markers (cyclin D1 and proliferating cell nuclear antigen (PCNA)).	Phosphorus	84-85	cyclin D1	Homo sapiens	189-198
27231235-7	2016	Additionally, combined treatment of FC and puromycin/doxorubicin promoted the activation of caspase 9/3, and attenuated the expression of c-Myc, Cyclin D1 and CDK4 in H1299 cells compared to single treatment.	farnesiferol C	36-38	cyclin D1	Homo sapiens	145-154
27109433-7	2016	Moreover, two well-known resveratrol effectors, cyclin D1 (CCND1) and cyclin B1 (CCNB1), were also repressed at both times.	Resveratrol	25-36	cyclin D1	Homo sapiens	48-57
27109433-7	2016	Moreover, two well-known resveratrol effectors, cyclin D1 (CCND1) and cyclin B1 (CCNB1), were also repressed at both times.	Resveratrol	25-36	cyclin D1	Homo sapiens	59-64
27109433-9	2016	By western blot assays, we confirmed that resveratrol suppressed AURKA, CCND1 and CCNB1 at 24 and 48 h. In summary, we showed for the first time that resveratrol regulates cell cycle progression by targeting AURKA and PLK1.	Resveratrol	42-53	cyclin D1	Homo sapiens	72-77
27109433-9	2016	By western blot assays, we confirmed that resveratrol suppressed AURKA, CCND1 and CCNB1 at 24 and 48 h. In summary, we showed for the first time that resveratrol regulates cell cycle progression by targeting AURKA and PLK1.	Resveratrol	150-161	cyclin D1	Homo sapiens	72-77
27252826-7	2016	Exogenous H2S (100 muM NaHS) inhibits vascular smooth muscle cells of human pulmonary aorta(HPASMC) proliferation and migration in response to high glucose using the BrdU and scratch wound repair assays, decreases proliferative protein (PCNA and cyclin D1) expression, and reduces ROS production in the cytoplasm and mitochondria.	Hydrogen Sulfide	10-13	cyclin D1	Homo sapiens	246-255
27252826-7	2016	Exogenous H2S (100 muM NaHS) inhibits vascular smooth muscle cells of human pulmonary aorta(HPASMC) proliferation and migration in response to high glucose using the BrdU and scratch wound repair assays, decreases proliferative protein (PCNA and cyclin D1) expression, and reduces ROS production in the cytoplasm and mitochondria.	sodium bisulfide	23-27	cyclin D1	Homo sapiens	246-255
27313460-13	2016	After closing target gene CCND1 in HepG2 cells, the number of cell migration and invasion in the small interfering (si)-CCND1 group were 0.444 and 0.435 times that of the si-NC group (P&lt;0.05); and compared to the si-NC group, the migration and inhibition rates were 55.6% and 56.5%, respectively.	Silicon	9-11	cyclin D1	Homo sapiens	120-125
27313460-13	2016	After closing target gene CCND1 in HepG2 cells, the number of cell migration and invasion in the small interfering (si)-CCND1 group were 0.444 and 0.435 times that of the si-NC group (P&lt;0.05); and compared to the si-NC group, the migration and inhibition rates were 55.6% and 56.5%, respectively.	Silicon	85-87	cyclin D1	Homo sapiens	120-125
27313460-13	2016	After closing target gene CCND1 in HepG2 cells, the number of cell migration and invasion in the small interfering (si)-CCND1 group were 0.444 and 0.435 times that of the si-NC group (P&lt;0.05); and compared to the si-NC group, the migration and inhibition rates were 55.6% and 56.5%, respectively.	Silicon	85-87	cyclin D1	Homo sapiens	120-125
27129163-0	2016	Downregulation of cyclin D1 sensitizes cancer cells to MDM2 antagonist Nutlin-3.	nutlin 3	71-79	cyclin D1	Homo sapiens	18-27
27231235-7	2016	Additionally, combined treatment of FC and puromycin/doxorubicin promoted the activation of caspase 9/3, and attenuated the expression of c-Myc, Cyclin D1 and CDK4 in H1299 cells compared to single treatment.	Puromycin	43-52	cyclin D1	Homo sapiens	145-154
27231235-7	2016	Additionally, combined treatment of FC and puromycin/doxorubicin promoted the activation of caspase 9/3, and attenuated the expression of c-Myc, Cyclin D1 and CDK4 in H1299 cells compared to single treatment.	Doxorubicin	53-64	cyclin D1	Homo sapiens	145-154
27224031-5	2016	We identified two novel SUMO-acceptor sites within the La protein located between the RNA recognition motif 1 and 2 and we demonstrate for the first time that sumoylation facilitates the RNA-binding of La to small RNA oligonucleotides representing the oligopyrimidine tract (TOP) elements from the 5" untranslated regions (UTR) of mRNAs encoding ribosomal protein L22 and L37 and to a longer RNA element from the 5" UTR of cyclin D1 (CCND1) mRNA in vitro.	oligopyrimidine	252-267	cyclin D1	Homo sapiens	423-432
27224031-5	2016	We identified two novel SUMO-acceptor sites within the La protein located between the RNA recognition motif 1 and 2 and we demonstrate for the first time that sumoylation facilitates the RNA-binding of La to small RNA oligonucleotides representing the oligopyrimidine tract (TOP) elements from the 5" untranslated regions (UTR) of mRNAs encoding ribosomal protein L22 and L37 and to a longer RNA element from the 5" UTR of cyclin D1 (CCND1) mRNA in vitro.	oligopyrimidine	252-267	cyclin D1	Homo sapiens	434-439
25779086-0	2016	Aluminum oxide nanoparticles alter cell cycle progression through CCND1 and EGR1 gene expression in human mesenchymal stem cells.	Aluminum Oxide	0-14	cyclin D1	Homo sapiens	66-71
27017931-0	2016	Down-regulation of hTERT and Cyclin D1 transcription via PI3K/Akt and TGF-beta pathways in MCF-7 Cancer cells with PX-866 and Raloxifene.	Raloxifene Hydrochloride	126-136	cyclin D1	Homo sapiens	29-38
27064011-10	2016	Honokiol provoked signal-transducing downregulation of CDK6, CDK4, cyclin D1, phosphorylated (p)RB, and E2F1.	honokiol	0-8	cyclin D1	Homo sapiens	67-76
27064011-12	2016	Honokiol-induced alterations in levels of CDK6, CDK4, cyclin D1, p-RB, and E2F1 were attenuated by PFN-alpha.	honokiol	0-8	cyclin D1	Homo sapiens	54-63
27064011-14	2016	In our in vivo model, administration of honokiol prolonged the survival rate of nude mice implanted with U87 MG cells and induced caspase-3 activation and chronological changes in p53, p21, CDK6, CDK4, cyclin D1, p-RB, and E2F1.	honokiol	40-48	cyclin D1	Homo sapiens	202-211
27064011-15	2016	CONCLUSIONS: Honokiol can repress human glioma growth by inducing apoptosis and cell cycle arrest in tumor cells though activating a p53/cyclin D1/CDK6/CDK4/E2F1-dependent pathway.	honokiol	13-21	cyclin D1	Homo sapiens	137-146
26861731-9	2016	The downregulation of cyclinD1 and upregulation of p27 were abolished by co-treatment with CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	91-99	cyclin D1	Homo sapiens	22-30
26013878-0	2016	PI3K target based novel cyano derivative of betulinic acid induces its signalling inhibition by down-regulation of pGSK3beta and cyclin D1 and potentially checks cancer cell proliferation.	betulinic acid	44-58	cyclin D1	Homo sapiens	129-138
25648304-2	2016	DHA upregulated Src homology region 2 domain-containing protein tyrosine phosphatase-1 (SHP-1) protein levels and suppressed levels of phosphorylated signal transducer and activator of transcription-3 (pStat3) and its downstream mediators c-Myc, and cyclin D1.	Docosahexaenoic Acids	0-3	cyclin D1	Homo sapiens	250-259
26878773-5	2016	We also found that tBHQ relieved the G2/M phase arrest by arsenic exposure, which was associated with altering the expression of cell cycle regulators cyclin D1 and CDK4.	2-tert-butylhydroquinone	19-23	cyclin D1	Homo sapiens	151-160
26878773-5	2016	We also found that tBHQ relieved the G2/M phase arrest by arsenic exposure, which was associated with altering the expression of cell cycle regulators cyclin D1 and CDK4.	Arsenic	58-65	cyclin D1	Homo sapiens	151-160
25968914-8	2016	Quercetin-induced MET was linked with the alteration of nuclear localization of beta-catenin and modulation of beta-catenin target genes such as cyclin D1 and c-Myc.	Quercetin	0-9	cyclin D1	Homo sapiens	145-154
27143925-4	2016	Our results demonstrated that the molecular mechanisms of the effect of carvacrol in Tca-8113 induces G1/S cell cycle arrest through downregulation of CDK regulator CCND1 and CDK4, and upregulation of CDK inhibitor P21.	carvacrol	72-81	cyclin D1	Homo sapiens	165-170
25969134-4	2016	Further, our in vitro studies demonstrate that 3-AWA treatment amplified E-cadherin expression along with sharp downregulation of c-Myc and cyclin D1 proteins.	3-azidowithaferin A	47-52	cyclin D1	Homo sapiens	140-149
27035431-7	2016	Western blot analysis indicated that artemisinin induced the expression of p16, while down-regulating phosphorylated extracellular signal-regulated kinase (ERK)1/2, CDK4 and cyclin D1 expression, leading to inhibition of the ERK1/2 pathway.	artemisinin	37-48	cyclin D1	Homo sapiens	174-183
26986084-3	2016	The inhibition of cell viability by cantharidin in HepG2 CD133+ and parental cells was significant at the concentration 5 and 15 microM, respectively after 48 h. Cantharidin treatment inhibited the self-renewal ability of the HCSCs and the expression of beta-catenin and cyclin D1.	Cantharidin	36-47	cyclin D1	Homo sapiens	271-280
26986084-3	2016	The inhibition of cell viability by cantharidin in HepG2 CD133+ and parental cells was significant at the concentration 5 and 15 microM, respectively after 48 h. Cantharidin treatment inhibited the self-renewal ability of the HCSCs and the expression of beta-catenin and cyclin D1.	Cantharidin	162-173	cyclin D1	Homo sapiens	271-280
26909600-6	2016	Ectopic expression of miR-329 in lung cancer cell lines substantially repressed cell growth as evidenced by cell viability assay, colony formation assay and BrdU staining, through inhibiting cyclin D1, cyclin D2 and up-regulatiing p57(Kip2) and p21(WAF1/CIP1).	mir-329	22-29	cyclin D1	Homo sapiens	191-200
27090655-9	2016	Analyzing mechanism of action interference of the mTOR inhibitor sirolimus shows specific impact on the drug resistance signature imposed by cisplatin and paclitaxel, further holding evidence for a synthetic lethal interaction to paclitaxel mechanism of action involving cyclin D1.	Sirolimus	65-74	cyclin D1	Homo sapiens	271-280
27090655-9	2016	Analyzing mechanism of action interference of the mTOR inhibitor sirolimus shows specific impact on the drug resistance signature imposed by cisplatin and paclitaxel, further holding evidence for a synthetic lethal interaction to paclitaxel mechanism of action involving cyclin D1.	Paclitaxel	230-240	cyclin D1	Homo sapiens	271-280
26986571-6	2016	Metformin repressed E2-inducible estrogen response element (ERE) luciferase activity, protein levels and mRNA levels of E2/ERalpha-regulated genes [including c-Myc, cyclin D1, progesterone receptor (PR) and pS2] to a greater degree than tamoxifen, resulting in inhibition of cell proliferation of MCF-7, TR MCF-7 and MDA-MB-361 cells.	Metformin	0-9	cyclin D1	Homo sapiens	165-174
27097161-4	2016	Furthermore, CIP downregulated the phosphorylation of Akt, PDK and mTOR proteins and decreased expression of cyclin D1, Bcl-2, survivin, VEGF, procaspase-3 and increased cleavage of PARP.	cip	13-16	cyclin D1	Homo sapiens	109-118
27143925-4	2016	Our results demonstrated that the molecular mechanisms of the effect of carvacrol in Tca-8113 induces G1/S cell cycle arrest through downregulation of CDK regulator CCND1 and CDK4, and upregulation of CDK inhibitor P21.	tca-8113	85-93	cyclin D1	Homo sapiens	165-170
26776764-5	2016	In our study, we found that benzidine increased the proliferation of human bladder cancer T24 cells, triggered transition of the cells from G1 to S phase, elevated the expression of cyclin D1 and proliferating cell nuclear antigen (PCNA) and decreased p21 expression.	benzidine	28-37	cyclin D1	Homo sapiens	182-191
27077843-4	2016	In this paper, we reported that GL-1196, as a small molecular compound, effectively suppressed the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclinD1 pathway and CDK4/6 expression.	glycylleucine	32-34	cyclin D1	Homo sapiens	185-193
26905586-8	2016	PGIA induced cyclin D1 degradation via the proteasome pathway and induced dephosphorylation of GSK3beta, which was required for cyclin D1 turnover.	pgia	0-4	cyclin D1	Homo sapiens	13-22
26905586-8	2016	PGIA induced cyclin D1 degradation via the proteasome pathway and induced dephosphorylation of GSK3beta, which was required for cyclin D1 turnover.	pgia	0-4	cyclin D1	Homo sapiens	128-137
26905586-9	2016	Furthermore, cyclin D1 overexpression rescued GBM cells from the cell growth inhibition by PGIA.	pgia	91-95	cyclin D1	Homo sapiens	13-22
26307133-7	2016	CONCLUSIONS: We observed improved treatment response with CPS in patients with melanoma whose tumors have RAF1 (cRAF), KRAS, or CCND1 amplification, all of which can be attributed to sorafenib targeting CRAF.	Sorafenib	183-192	cyclin D1	Homo sapiens	128-133
27150989-4	2016	RESULTS: 20 micromol/L XAV-939 and 20 mmol/L LiCl could effectively inhibit and activate Wnt signalling pathway of HL-60 cells respectively, could significantly down- and up-regulate the expression of cyclinD1, TCF1 and c-Jun genes (P &lt; 0.05) and proteins (P &lt; 0.05); moreover, the number of CD10(+) HL-60 cells in these conditions was below 1%, no early apoptosis of HL-60 cells was found.	XAV939	23-26	cyclin D1	Homo sapiens	201-209
27150989-4	2016	RESULTS: 20 micromol/L XAV-939 and 20 mmol/L LiCl could effectively inhibit and activate Wnt signalling pathway of HL-60 cells respectively, could significantly down- and up-regulate the expression of cyclinD1, TCF1 and c-Jun genes (P &lt; 0.05) and proteins (P &lt; 0.05); moreover, the number of CD10(+) HL-60 cells in these conditions was below 1%, no early apoptosis of HL-60 cells was found.	Lithium Chloride	45-49	cyclin D1	Homo sapiens	201-209
27031247-9	2016	Pre-treatment with AZD2014 in irradiated oral cancer cells induced tumor cell cycle arrest at the G1 and G2/M phases, which led to disruption of cyclin D1-CDK4 and cyclin B1-CDC2 complexes.	vistusertib	19-26	cyclin D1	Homo sapiens	145-154
26621841-6	2016	Clofibrate treatment reduced the proliferation of breast cancer cells probably by inhibiting NF-kappaB and ERK1/2 activation, reducing cyclinD1, cyclinA, cyclinE, and inducing pro-apoptotic P21 levels.	Clofibrate	0-10	cyclin D1	Homo sapiens	135-143
27014877-5	2016	Co-treatment with BC-23 at low concentrations effectively inhibits Wnt/beta-catenin signaling and down-regulates c-Myc and cyclin D1 expression.	NSC45382	18-23	cyclin D1	Homo sapiens	123-132
26965928-12	2016	Moreover, deferasirox induced G1 arrest; upregulated p21, p27, and p53 expression; and downregulated cyclin D1, cyclin B, and CDK4 expression.	Deferasirox	10-21	cyclin D1	Homo sapiens	101-110
26663097-9	2016	In addition, DMF suppressed Cyclin D1 and Cyclin A expression in a concentration-dependent manner.	Dimethyl Fumarate	13-16	cyclin D1	Homo sapiens	28-37
25840567-9	2016	Inhibition of GSK3beta by LiCl led to increased levels of beta-catenin, LEF-1, cyclin D1, and CXCR-4 expression.	Lithium Chloride	26-30	cyclin D1	Homo sapiens	79-88
25840567-10	2016	Our data indicate that GSK3beta plays an important role in regulating the proliferation and migration of BMSCs by inhibiting cyclin D1 and CXCR-4 under high glucose conditions.	Glucose	157-164	cyclin D1	Homo sapiens	125-134
26707712-9	2016	During the study of the related mechanisms, we found an upregulation of p27 and downregulation of cyclin D1 as well as CDK4 after darbufelone treatment, which indicated that darbufelone could arrest the cell cycle of LoVo cells at the G0/G1 phase.	darbufelone	174-185	cyclin D1	Homo sapiens	98-107
26718494-9	2016	The present study indicated that BNMPH and its copper complex effectively induced S phase arrest and the cell cycle arrest was associated with the downregulation of cyclin D1.	Copper	47-53	cyclin D1	Homo sapiens	165-174
26443539-10	2016	Blockage of FAK using inhibitor PF573228 abolished the role of Rab5a on cyclin D1.	6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one	32-40	cyclin D1	Homo sapiens	72-81
26616281-0	2016	Alkaloids derived from flowers of Senna spectabilis, (-)-cassine and (-)-spectaline, have antiproliferative activity on HepG2 cells for inducing cell cycle arrest in G1/S transition through ERK inactivation and downregulation of cyclin D1 expression.	Alkaloids	0-9	cyclin D1	Homo sapiens	229-238
26616281-0	2016	Alkaloids derived from flowers of Senna spectabilis, (-)-cassine and (-)-spectaline, have antiproliferative activity on HepG2 cells for inducing cell cycle arrest in G1/S transition through ERK inactivation and downregulation of cyclin D1 expression.	cassine	53-64	cyclin D1	Homo sapiens	229-238
26616281-0	2016	Alkaloids derived from flowers of Senna spectabilis, (-)-cassine and (-)-spectaline, have antiproliferative activity on HepG2 cells for inducing cell cycle arrest in G1/S transition through ERK inactivation and downregulation of cyclin D1 expression.	spectaline	69-83	cyclin D1	Homo sapiens	229-238
26932893-9	2016	In addition, expression of p16 was increased, and expressions of p-ERK1/2, CDK4 and cyclin D1 were down-regulated by artemisinin(all P&lt;0.05).	artemisinin	117-128	cyclin D1	Homo sapiens	84-93
26926171-0	2016	The involvement of cyclin D1 degradation through GSK3beta-mediated threonine-286 phosphorylation-dependent nuclear export in anti-cancer activity of mulberry root bark extracts.	Threonine	67-76	cyclin D1	Homo sapiens	19-28
26926171-11	2016	Inhibition of proteasomal degradation by MG132 attenuated MRB-mediated cyclin D1 downregulation and the half-life of cyclin D1 was decreased in the cells treated with MRB.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	41-46	cyclin D1	Homo sapiens	71-80
26926171-12	2016	In addition, MRB increased phosphorylation of cyclin D1 at threonine-286 and a point mutation of threonine-286 to alanine attenuated MRB-mediated cyclin D1 degradation.	Threonine	59-68	cyclin D1	Homo sapiens	46-55
26926171-13	2016	Inhibition of GSK3beta by LiCl suppressed cyclin D1 phosphorylation and downregulation by MRB.	Lithium Chloride	26-30	cyclin D1	Homo sapiens	42-51
26926171-15	2016	CONCLUSION: MRB has anti-cancer activity by inducing cyclin D1 proteasomal degradation through cyclin D1 nuclear export via GSK3beta-dependent threonine-286 phosphorylation.	Threonine	143-152	cyclin D1	Homo sapiens	53-62
26089158-5	2016	Gene ablation of FoxO3A prevented gAcrp-induced increase in p27 and decreased in cyclin D1 expression, and further ameliorated cell cycle arrest by gAcrp, indicating a critical role of FoxO3A in gAcrp-induced cell cycle arrest of cancer cells.	gacrp	34-39	cyclin D1	Homo sapiens	81-90
26878784-6	2016	The treatment of the cells with TCS up-regulated the protein expressions of cyclin D1, cyclin E and cathepsin D, while down-regulated p21 and bax expressions.	9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide	32-35	cyclin D1	Homo sapiens	76-85
26437743-13	2016	AKT mediates casodex resistance and androgen independence through regulation of cyclin D1.	bicalutamide	13-20	cyclin D1	Homo sapiens	80-89
26586345-6	2016	Additionally, inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 1B by AZ191 reversed LGX818-induced CyclinD1 turnover and senescence.	AZ191	93-98	cyclin D1	Homo sapiens	123-131
26847145-5	2016	Lico B caused cell cycle arrest at G1 phase along with downregulation of cyclin D1 and upregulation of p21 and p27 proteins.	licochalcone B	0-6	cyclin D1	Homo sapiens	73-82
26556739-11	2016	Mechanistic studies showed that Dex inhibited BMSC proliferation by microRNA-34a-5p targeting cell cycle factors, including CDK4, CDK6, and Cyclin D1.	Dexamethasone	32-35	cyclin D1	Homo sapiens	140-149
27051274-7	2016	AZD1080 also significantly downregulated GSK-3beta, CDK2, CDK1, cyclin D1, MMP9, and Bcl-xL expression at both mRNA and protein levels.	2-hydroxy-3-(5-((morpholin-4-yl)methyl)pyridin-2-yl)-1H-indole-5-carbonitrile	0-7	cyclin D1	Homo sapiens	64-73
26872218-7	2016	Additionally, treatment of SB203580, a p38 MAPK specific inhibitor, reversed the inhibition of PCNA, cyclin D1, and Bcl-2 expression induced by 2alpha-hydroxyursolic acid in MDA-MB-231 cells.	SB 203580	27-35	cyclin D1	Homo sapiens	95-110
26872218-7	2016	Additionally, treatment of SB203580, a p38 MAPK specific inhibitor, reversed the inhibition of PCNA, cyclin D1, and Bcl-2 expression induced by 2alpha-hydroxyursolic acid in MDA-MB-231 cells.	2-hydroxyursolic acid	144-170	cyclin D1	Homo sapiens	95-110
25840567-8	2016	We showed that high glucose activates GSK3beta but suppresses CXCR-4, beta-catenin, LEF-1, and cyclin D1.	Glucose	20-27	cyclin D1	Homo sapiens	95-104
26832795-1	2016	Our recent studies found that isorhapontigenin (ISO) showed a significant inhibitory effect on human bladder cancer cell growth, accompanied with cell-cycle G0-G1 arrest as well as downregulation of Cyclin D1 expression at transcriptional level via inhibition of Sp1 transactivation in bladder cancer cells.	isorhapontigenin	30-46	cyclin D1	Homo sapiens	199-208
26832795-1	2016	Our recent studies found that isorhapontigenin (ISO) showed a significant inhibitory effect on human bladder cancer cell growth, accompanied with cell-cycle G0-G1 arrest as well as downregulation of Cyclin D1 expression at transcriptional level via inhibition of Sp1 transactivation in bladder cancer cells.	isorhapontigenin	48-51	cyclin D1	Homo sapiens	199-208
26846278-3	2016	The results demonstrated that the proportion of SH-SY5Y cells in G1 phase was significantly increased following treatment with isatin for 48 h with simultaneous downregulation of cyclin D1 expression.	Isatin	127-133	cyclin D1	Homo sapiens	179-188
26846278-6	2016	These results demonstrated that isatin induces G1-phase arrest in SH-SY5Y cells, possibly by decreasing cyclin D1 expression as well as inhibiting their migration and invasiveness, probably by reducing MMP2 and MMP9.	Isatin	32-38	cyclin D1	Homo sapiens	104-113
26657292-0	2016	Mitochondrial reactive oxygen species perturb AKT/cyclin D1 cell cycle signaling via oxidative inactivation of PP2A in lowdose irradiated human fibroblasts.	Reactive Oxygen Species	14-37	cyclin D1	Homo sapiens	50-59
26657292-3	2016	Excess ROS promoted oxidative inactivation of protein phosphatase PP2A which in turn led to disruption of normal negative feed-back control of AKT/cyclin D1 signaling in cells treated with long-term FR.	Reactive Oxygen Species	7-10	cyclin D1	Homo sapiens	147-156
26657292-6	2016	Our study highlights a specific role of mitochondrial ROS in perturbation of AKT/cyclin D1 cell cycle signaling after low-dose long-term FR.	Reactive Oxygen Species	54-57	cyclin D1	Homo sapiens	81-90
28955838-9	2016	Further, mangiferin enhanced the expression of cell proliferative signaling cascade molecules, Cyclin d1, NFkappaB and antioxidant molecules HO-1, SOD2, by PI3K/Akt dependent pathway.	mangiferin	9-19	cyclin D1	Homo sapiens	95-104
27095936-11	2016	However, combined treatment of everolimus and paclitaxel significantly reduced BCL2 and CCND1 mRNA expression (p &lt; 0.05).	Everolimus	31-41	cyclin D1	Homo sapiens	88-93
26751081-6	2016	The quantitative real-time PCR data showed that (+)-usnic acid decreased the mRNA level of CD44, Cyclin D1 and c-myc, which are the downstream target genes of both beta-catenin/LEF and c-jun/AP-1.	usnic acid	48-62	cyclin D1	Homo sapiens	97-106
27889776-9	2016	The western blot analysis results showed that KLF6, Fas-L, Bax, P53 and caspase-3 protein expression was drastically increased in the CNE2 cells after treatment with 2 mmol/L CINN, whereas Bcl-2 and cyclin D1 protein expression was markedly reduced.	cinnamic acid	175-179	cyclin D1	Homo sapiens	199-208
26938985-11	2016	Moreover, DHT-dependent activation of AR involves regulation in the cell cycle related genes, including p73, p21 and Cyclin D1.	Dihydrotestosterone	10-13	cyclin D1	Homo sapiens	117-126
27832629-7	2016	The changes included G1 and G2/M phase arrest of the cell cycle, and a downregulation of the expression at both the protein and mRNA levels of cyclin D1 and CDK4 (related to the G1 phase) and of cyclin B1 and CDK1 (related to the G2/M phase) as measured by flow cytometry after propidium iodide staining, and both western blot and real-time PCR, respectively.	Propidium	278-294	cyclin D1	Homo sapiens	143-152
27832629-9	2016	Co-immunoprecipitation further confirmed that there was an interaction between p-ERK1/2 and cyclin D1, CDK4, cyclin B1, or CDK1, which was blunted in the presence of melatonin or PD98059.	Melatonin	166-175	cyclin D1	Homo sapiens	92-101
27832629-9	2016	Co-immunoprecipitation further confirmed that there was an interaction between p-ERK1/2 and cyclin D1, CDK4, cyclin B1, or CDK1, which was blunted in the presence of melatonin or PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	179-186	cyclin D1	Homo sapiens	92-101
27095936-0	2016	Reduced BCL2 and CCND1 mRNA expression in human cervical cancer HeLa cells treated with a combination of everolimus and paclitaxel.	Everolimus	105-115	cyclin D1	Homo sapiens	17-22
27095936-0	2016	Reduced BCL2 and CCND1 mRNA expression in human cervical cancer HeLa cells treated with a combination of everolimus and paclitaxel.	Paclitaxel	120-130	cyclin D1	Homo sapiens	17-22
27095936-11	2016	However, combined treatment of everolimus and paclitaxel significantly reduced BCL2 and CCND1 mRNA expression (p &lt; 0.05).	Paclitaxel	46-56	cyclin D1	Homo sapiens	88-93
27095936-3	2016	In this study, we aimed to investigate the effects of everolimus, gemcitabine, and paclitaxel in terms of cell viability and mRNA expression levels of GRP78, CCND1, CASP2, and BCL2 genes.	Everolimus	54-64	cyclin D1	Homo sapiens	158-163
27095936-3	2016	In this study, we aimed to investigate the effects of everolimus, gemcitabine, and paclitaxel in terms of cell viability and mRNA expression levels of GRP78, CCND1, CASP2, and BCL2 genes.	gemcitabine	66-77	cyclin D1	Homo sapiens	158-163
27095936-13	2016	CONCLUSIONS: Down-regulation of CCND1 and BCL2 expression may be an important mechanism by which everolimus increases the therapeutic window of paclitaxel in cervical cancers.	Everolimus	97-107	cyclin D1	Homo sapiens	32-37
27095936-3	2016	In this study, we aimed to investigate the effects of everolimus, gemcitabine, and paclitaxel in terms of cell viability and mRNA expression levels of GRP78, CCND1, CASP2, and BCL2 genes.	Paclitaxel	83-93	cyclin D1	Homo sapiens	158-163
27095936-13	2016	CONCLUSIONS: Down-regulation of CCND1 and BCL2 expression may be an important mechanism by which everolimus increases the therapeutic window of paclitaxel in cervical cancers.	Paclitaxel	144-154	cyclin D1	Homo sapiens	32-37
26382555-4	2016	In addition, the downregulation of Wnt, beta-catenin and cyclinD1 expression levels was detected in TMPyP4-treated SW480 cells.	tetra(4-N-methylpyridyl)porphine	100-106	cyclin D1	Homo sapiens	57-65
27006530-9	2016	IL-6 blockade and carboplatin synergistically reduced cyclin D1 expression and enhanced caspase-3 activity in LoVo cells.	Carboplatin	18-29	cyclin D1	Homo sapiens	54-63
26648539-7	2016	Compared with shHSP27 or quercetin alone, shHSP27 plus quercetin markedly decreased the protein expression of cyclinD1 and thus blocked the cell cycle at G1 phase.	Quercetin	25-34	cyclin D1	Homo sapiens	110-118
26647836-4	2016	In addition, hesperetin blocked the progression of the cell cycle from G0/G1 to S phase, which was correlated with the decreased mRNA expression levels of cyclin D1, cyclin E, cyclin-dependent kinase (CDK)2 and CDK4, and the increased mRNA expression levels of p27.	hesperetin	13-23	cyclin D1	Homo sapiens	155-164
26774143-8	2016	Western blot analysis showed that after being treated with fengycin, Bax, Caspase-3, and Caspase-6 expressions were increased, however, Bcl-2, and CDK4/cyclin D1 expressions were decreased (P&lt;0.05).Our study suggested that fengycin may play certain inhibit roles in the development and progression of colon cancer through involving in the cell apoptosis and cell cycle processes by targeting the Bax/Bcl-2 pathway.	fengycin	59-67	cyclin D1	Homo sapiens	152-161
27008503-2	2016	delta-T induces tumor cell death through peroxisome proliferator-activated receptor gamma (PPAR-gamma) induction, cyclin-D1 inhibition, and modulation of redox balance.	delta-tocopherol	0-7	cyclin D1	Homo sapiens	114-123
26530632-5	2016	Furthermore, western blotting demonstrated that resveratrol decreased the protein expression of phospho-glycogen synthase kinase 3beta (p-GSK3beta), cyclin D1, phospho-phosphatase and tensin homologue (p-PTEN), phospho-phosphatidylinositol 3"-OH kinase (p-PI3K), and phospho-protein kinase B (p-PKB/Akt).	Resveratrol	48-59	cyclin D1	Homo sapiens	149-158
26531053-0	2016	Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and cyclin D1-mediated tumour cell inhibition in non-small cell lung cancer cell lines.	Curcumin	0-8	cyclin D1	Homo sapiens	96-105
26531053-0	2016	Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and cyclin D1-mediated tumour cell inhibition in non-small cell lung cancer cell lines.	Cisplatin	34-43	cyclin D1	Homo sapiens	96-105
26802652-7	2016	Additionally, PI3K-specific inhibitor Ly294002 suppressed the expression of pPI3K (Tyr458), pAkt (Ser473), CCND1, and CDK4 in PC9-shPDCD4 and A549-shPDCD4 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	cyclin D1	Homo sapiens	107-112
26802652-8	2016	Furthermore, Akt-specific inhibitor MK2206 inhibited the expression of pAkt (Ser473), CCND1, and CDK4 in PC9-shPDCD4 and A549-shPDCD4 cells.	MK 2206	36-42	cyclin D1	Homo sapiens	86-91
26870186-8	2016	Cell cycle-associated proteins, including phosphorylated protein kinase B, cyclin D1, cyclin dependent kinase (CDK) 2 and CDK6 were downregulated by BCTC, while phosphorylated glycogen synthase kinase 3beta was upregulated.	BCTC	149-153	cyclin D1	Homo sapiens	75-84
26849623-4	2016	Western blot demonstrated that DYC-279-induced G2/M arrest effect was correlated with the inhibition of cyclin-dependent kinase 1 activity, including a concomitant downregulation of cyclinD1 and cdc2 and upregulation of cyclinB1 in HepG2 cells.	DYC-279	31-38	cyclin D1	Homo sapiens	182-190
26977159-5	2016	After EGCG treatment, expressions of beta-catenin and cyclin D1 were upregulated, suggesting that the Wnt pathway was involved in the effects of EGCG on the osteogenic differentiation of BM-MSCs.	epigallocatechin gallate	6-10	cyclin D1	Homo sapiens	54-63
26845717-9	2016	Furthermore, the triterpenoids increased the expression of cyclin-B1, cyclin-D1 and cleaved caspase-3, as determined by immunofluorescence, indicating an important role of apoptosis in cell death induced by these compounds.	triterpenoids	17-30	cyclin D1	Homo sapiens	70-79
26681199-0	2015	Negative effect of cyclin D1 overexpression on recurrence-free survival in stage II-IIIA lung adenocarcinoma and its expression modulation by vorinostat in vitro.	Vorinostat	142-152	cyclin D1	Homo sapiens	19-28
26681199-6	2015	Vorinostat inhibited cell cycle progression to the S-phase and induced down-regulation of cyclin D1 in vitro.	Vorinostat	0-10	cyclin D1	Homo sapiens	90-99
26681199-7	2015	The down-regulation of cyclin D1 by vorinostat was comparable to a siRNA-mediated knockdown of cyclin D1 in A549 cells, but vorinostat in the presence of benzo[a]pyrene showed a differential effect in different lung cancer cell lines.	Vorinostat	36-46	cyclin D1	Homo sapiens	23-32
26681199-8	2015	Cyclin D1 down-regulation by vorinostat was associated with the accumulation of dimethyl-H3K9 at the promoter of the gene.	Vorinostat	29-39	cyclin D1	Homo sapiens	0-9
26673922-7	2015	Sulindac sulfide also decreased expression of several Sp-regulated genes that are critical for cancer cell survival, proliferation and angiogenesis and these include survivin, bcl-2, epidermal growth factor receptor (EGFR), cyclin D1, p65 subunit of NFkappaB and vascular endothelial growth factor (VEGF).	sulindac sulfide	0-16	cyclin D1	Homo sapiens	224-233
26246306-7	2015	Though rare adenocarcinomas showed cyclin D1 loss, many of these were associated with clinical features of small-cell carcinoma, and in a cohort of men treated with adjuvant ADT who developed metastasis, lower cyclin D1 gene expression was associated with more rapid onset of metastasis and death.	adt	174-177	cyclin D1	Homo sapiens	210-219
26506573-8	2015	The mechanism of this result may be related to sulfite dependent inhibition of cell cycle at the G1 phase by down-regulating URG4/URGCP or CCND1, CDK4, CDK6 gene expression and stimulating apoptosis via the intrinsic pathway.	Sulfites	47-54	cyclin D1	Homo sapiens	139-144
26589262-4	2015	We found that cAMP increased cyclin D1 expression in P-NET and QGP-1 cells, whereas it had opposite effects on bronchial carcinoids and H727 cells and it promoted cell adhesion in QGP-1 and H727 cells.	Cyclic AMP	14-18	cyclin D1	Homo sapiens	29-38
30090349-7	2016	The inhibition of cellular proliferation by probucol was caused by G1-phase arrest through regulating proteins associated with cell cycle progression, such as cyclin D1, p21Waf1/Cip1, and p27Kip1.	Probucol	44-52	cyclin D1	Homo sapiens	159-168
26677902-5	2015	Additionally, down-regulation of cyclin D1, A2, E1, Cdk2 and up-regulation of p21, p27 were detected after the treatment with clioquinol.	Clioquinol	126-136	cyclin D1	Homo sapiens	33-42
26648539-7	2016	Compared with shHSP27 or quercetin alone, shHSP27 plus quercetin markedly decreased the protein expression of cyclinD1 and thus blocked the cell cycle at G1 phase.	Quercetin	55-64	cyclin D1	Homo sapiens	110-118
26788160-8	2015	Furthermore, compared with the control treatment, treatment with 1.0 microM niclosamide downregulated the expression of cyclin D1 to 52.4+-4.4 and 23.9+-5.4% (P&lt;0.05) in the HLF and PRL/PRF/5 cells, respectively.	Niclosamide	76-87	cyclin D1	Homo sapiens	120-129
26416848-5	2015	Knockdown of A2B receptors prevented the effects of 2-chloroadenosine on ERK1/2, Akt, Skp2, p27(Kip1), cyclin D1, cyclin A, and proliferation.	2-Chloroadenosine	52-69	cyclin D1	Homo sapiens	103-112
25307746-8	2015	Moreover, PGZ inhibited proliferative activity and invasive potential, and induced apoptosis and cell cycle arrest in HCC cells resulting in increased expression of PPARgamma and decreased expression of RAGE, NF-kappaB, HMGB1, p38MAPK, Ki-67, MMP-2, and CyclinD1.	Pioglitazone	10-13	cyclin D1	Homo sapiens	254-262
26458285-6	2015	Further investigations indicated that the enhancement of CPPP-mediated antitumor effects by GRIM-19 may be associated with the upregulation of phosphorylated p53 and the downregulation of B cell lymphoma-2, cyclin D1, vascular endothelial growth factor, matrix metalloproteinase (MMP)-2 and MMP-9, the proteins of which are involved in the activation of signal transducer and activator of transcription 3.	4-carboxy-5-(pyridyloxy-5'-phosphate)proline	57-61	cyclin D1	Homo sapiens	207-216
26398221-5	2015	Metformin treatment also led to marked decreases in cyclin D1 and cyclin-dependent kinase (Cdk) 4 protein levels and retinoblastoma protein phosphorylation.	Metformin	0-9	cyclin D1	Homo sapiens	52-61
26343756-5	2015	Moreover, Bis-GMA induced a depletion of mitochondrial membrane potential, an increase in the Bax/Bcl-2 ratio, an activation of caspase-3 and altered expressions of cell cycle-related proteins (p21, PCNA, cyclinD1).	Bisphenol A-Glycidyl Methacrylate	10-17	cyclin D1	Homo sapiens	205-213
26177467-7	2015	Treatment with Gentian Violet and Brilliant Green was associated with a reduced cyclin D1 expression and activation of caspase 3 and/or 7.	Gentian Violet	15-29	cyclin D1	Homo sapiens	80-89
26177467-7	2015	Treatment with Gentian Violet and Brilliant Green was associated with a reduced cyclin D1 expression and activation of caspase 3 and/or 7.	brilliant green	34-49	cyclin D1	Homo sapiens	80-89
26706948-9	2015	Western blot analysis showed that, compared with the control group, thioridazine reduced the expressions of CyclinD1, Bcl-2 and Bcl-xl (P&lt;0.01) and increased the expression of Bax (P&lt;0.01).	Thioridazine	68-80	cyclin D1	Homo sapiens	108-116
26706948-11	2015	CONCLUSIONS: The mechanism of thioridazine inhibiting the proliferation of PC9 cells may be related to stimulation of Caspase apoptotic pathway, down-regulation of CyclinD1, Bcl-2, Bcl-xl and up-regulation of Bax.	Thioridazine	30-42	cyclin D1	Homo sapiens	164-172
26459366-6	2015	The protein levels of cleaved caspase-3, caspase-9 and poly ADP ribose polymerase were upregulated, while the levels of c-myc, survivin and cyclin D1 were downregulated following treatment with CPT.	cryptotanshinone	194-197	cyclin D1	Homo sapiens	140-149
26447757-4	2015	Knockdown of AMPKalpha significantly rescued nitroxoline-induced inhibition of cyclin D1-Rb-Cdc25A axis indicating AMPK-dependent mechanism.	nitroxoline	45-56	cyclin D1	Homo sapiens	79-88
26447757-8	2015	In conclusion, the data suggest that nitroxoline induces anticancer activity through AMPK-dependent inhibition of mTOR-p70S6K signaling pathway and cyclin D1-Rb-Cdc25A axis, leading to G1 arrest of cell cycle and apoptosis.	nitroxoline	37-48	cyclin D1	Homo sapiens	148-157
26440150-6	2015	Furthermore, the expression of beta-catenin target genes, cyclinD1, c-Myc and CD44, were significantly decreased, suggesting that fendiline might prevent cell proliferation and migration by inhibiting ADAM10 function, cadherin proteolysis and stabilization of cadherin-catenin interaction at the plasma membrane.	Fendiline	130-139	cyclin D1	Homo sapiens	58-66
26615000-8	2015	In comparison with Human umbilical vein endothelial cells in the control group, high glucose level increased the levels of TXNIP expression and ROS level in cells, but reduced cell proliferation as well as migration capability and expression levels of beta-catenin, Cyclin D1 and C-myc; the difference was statistically significant (P &lt; 0.05).	Glucose	85-92	cyclin D1	Homo sapiens	266-275
26531889-3	2015	Figure 1 shows the modulation of telomerase activity by herbimycin A in K562 cells: (a) cell cycle and (b) telomerase activity, mRNA expressions of hTERT, hTERC, TEP-1, c-myc, cyclin D1 and b-actin, and c-Myc protein.	herbimycin	56-68	cyclin D1	Homo sapiens	176-185
26531889-4	2015	The authors however wish to inform the readers that Figure 1b incorrectly shows hTERT mRNA, which is the result of herbimycin A treatment of cyclin-D1-transfected K562 cells (Figure 3b, hTERT mRNA).	herbimycin	115-127	cyclin D1	Homo sapiens	141-150
26407842-4	2015	Salinomycin suppressed cell viability, concomitant with the downregulation of cyclin D1 and increased p27(kip1) nuclear accumulation.	salinomycin	0-11	cyclin D1	Homo sapiens	78-87
26586936-7	2015	As4S4 inhibited COX2 and cyclin D1 expression.	as4s4	0-5	cyclin D1	Homo sapiens	25-34
26492346-6	2015	PNAP-6h led to cell arrest at the S phase, most likely due to increasing levels of p21 and p27 and decreasing levels of cyclin D1, CDK4, cyclin E, and CDK2.	6H	5-7	cyclin D1	Homo sapiens	120-129
26491966-6	2015	In addition, quercetin effectively suppressed the expression of CyclinD1, p21, Twist and phospho p38MAPK, which was not observed in MDA-MB-231 cells.	Quercetin	13-22	cyclin D1	Homo sapiens	64-72
26297991-7	2015	The mechanisms involved in these effects of XN were associated with cell growth inhibition by induction of cell cycle arrest in the G1 phase, increased p53 and p21/WAF1 expression levels, downregulation of cyclin D1 and Bcl-2, and activation of caspases-9, -8, and -3.	xanthohumol	44-46	cyclin D1	Homo sapiens	206-215
26219504-15	2015	HCB increased cyclin D1 protein levels and ERK1/2 phosphorylation in a dose-dependent manner.	Hexachlorobenzene	0-3	cyclin D1	Homo sapiens	14-23
26250568-4	2015	Magnolol also blocked cell cycle progression at G0 /G1 phase and induced mitochondrial-related apoptosis by upregulating p53 and p21 protein levels and by downregulating cyclin D1, CDC25A, and Cdk2 protein levels.	magnolol	0-8	cyclin D1	Homo sapiens	170-179
26275572-6	2015	After etodolac exposure mean cyclin D1 protein levels, assayed by immunohistochemistry, decreased (P = 0.03).	Etodolac	6-14	cyclin D1	Homo sapiens	29-38
26275572-7	2015	Notably, pre- versus post cyclin D1 gene expression change went from positive to negative with greater duration of etodolac exposure (r = -0.64, P = 0.01).	Etodolac	115-123	cyclin D1	Homo sapiens	26-35
26275572-9	2015	In resectable breast cancer relatively brief exposure to the NSAID etodolac was associated with reduced cyclin D1 protein levels.	Etodolac	67-75	cyclin D1	Homo sapiens	104-113
26722440-7	2015	Furthermore, allicin treatment enhanced the expression of cyclin D1, CDK4 and CDK6.	allicin	13-20	cyclin D1	Homo sapiens	58-67
26722440-8	2015	Therefore, allicin treatment enhances the proliferation of chondrocytes by promoting the transition from G1 to S phase of the cell cycle through increase in the expression of cyclin D1, CDK4 and CDK6 levels.	allicin	11-18	cyclin D1	Homo sapiens	175-184
26252371-9	2015	Gemcitabine inhibited cell cycle progression in HuCCT-1 cells from G0/G1 to S phase, resulting in G1 cell cycle arrest due to the reduction of cyclin D1 expression.	gemcitabine	0-11	cyclin D1	Homo sapiens	143-152
26310353-14	2015	FoxO3a target genes involved in cell cycle progression and apoptosis were also investigated, and combined treatment with butein and cisplatin resulted in the downregulation of cyclin D1 and Bcl-2 and the upregulation of p27 and Bax.	butein	121-127	cyclin D1	Homo sapiens	176-185
26310353-14	2015	FoxO3a target genes involved in cell cycle progression and apoptosis were also investigated, and combined treatment with butein and cisplatin resulted in the downregulation of cyclin D1 and Bcl-2 and the upregulation of p27 and Bax.	Cisplatin	132-141	cyclin D1	Homo sapiens	176-185
26095818-1	2015	In this study, overexpression of GADD45a induced by furazolidone in HepG2 cells could arouse S-phase cell cycle arrest, suppress cell proliferation, and increase the activities of cyclin D1, cyclin D3, and cyclin-dependent kinase 6 (CDK6).	Furazolidone	52-64	cyclin D1	Homo sapiens	180-189
26095818-3	2015	Moreover, data from our current studies show that cyclin D1, cyclin D3, and CDK6 are target genes functioning at the downstream of the GADD45a pathway induced by furazolidone.	Furazolidone	162-174	cyclin D1	Homo sapiens	50-59
26095818-5	2015	GADD45a influences furazolidone-induced S-phase cell cycle arrest in human hepatoma G2 cells via cyclin D1, cyclin D3, and CDK6, but not CDK4.	Furazolidone	19-31	cyclin D1	Homo sapiens	97-106
24798089-5	2015	The effect of celecoxib on cell cycle is associated with an induction of p27 and the down-regulation of cyclin D1.	Celecoxib	14-23	cyclin D1	Homo sapiens	104-113
24798214-8	2015	Our data suggest that cadmium exposure promotes breast cancer progression by (1) down-regulating E-cadherin, thus decreasing the number of E-cadherin/beta-catenin adhesion complexes, and (2) enhancing the nuclear translocation of beta-catenin to increase expression of cancer-promoting proteins (i.e., c-Jun and cyclin D1).	Cadmium	22-29	cyclin D1	Homo sapiens	312-321
24819444-3	2015	Piperine inhibited HT-29 colon carcinoma cell proliferation by causing G1 phase cell cycle arrest that was associated with decreased expression of cyclins D1 and D3 and their activating partner cyclin-dependent kinases 4 and 6, as well as reduced phosphorylation of the retinoblastoma protein and up-regulation of p21/WAF1 and p27/KIP1 expression.	piperine	0-8	cyclin D1	Homo sapiens	147-226
26166196-8	2015	The findings revealed that curcumin significantly decreased cell proliferation, which was associated with increased expression of the p21/CIP1 and p27/KIP1 cyclin-dependent kinase inhibitors, and inhibited expression of cyclin D1.	Curcumin	27-35	cyclin D1	Homo sapiens	220-229
26360782-6	2015	Furthermore, BK treatment of H2O2-exposed cells leads to elevated phosphorylation of RB, AKT, and cyclin D1 compared with H2O2-treatment alone.	Hydrogen Peroxide	29-33	cyclin D1	Homo sapiens	98-107
26210065-7	2015	Ergosterol peroxide inhibited the nuclear levels of beta-catenin, which ultimately resulted in reduced transcription of c-Myc, cyclin D1, and CDK-8.	ergosterol-5,8-peroxide	0-19	cyclin D1	Homo sapiens	127-136
26212545-5	2015	Sugiol induced cell cycle arrest and decreased the expression levels of STAT3 target genes, such as cyclin D1, cyclin A, and survivin.	sugiol	0-6	cyclin D1	Homo sapiens	100-109
26172301-5	2015	Our data indicate that CCND1 has a 4-fold lower binding affinity for AZ than does ODC and an approximately 40-fold lower binding affinity for AZ than does AZI.	alizarin	69-71	cyclin D1	Homo sapiens	23-28
26172301-5	2015	Our data indicate that CCND1 has a 4-fold lower binding affinity for AZ than does ODC and an approximately 40-fold lower binding affinity for AZ than does AZI.	alizarin	142-144	cyclin D1	Homo sapiens	23-28
26172301-5	2015	Our data indicate that CCND1 has a 4-fold lower binding affinity for AZ than does ODC and an approximately 40-fold lower binding affinity for AZ than does AZI.	azi	155-158	cyclin D1	Homo sapiens	23-28
26359868-10	2015	As2O3 also decreased the protein expressions of cyclin D1, cyclin E, cyclin B1, cyclin-dependent kinase (CDK) 2, and CDK4, but did not affect the protein expressions of p21 and p27.	Arsenic Trioxide	0-5	cyclin D1	Homo sapiens	48-57
25920498-7	2015	In contrast, GH-RT stimulated increases in clonogenic growth of erythroid lineage and RBC counts as well as significant up-regulation of cell cycle-propagating genes, including MAP2K1, cyclins D1/E1, PCNA, and IGF1.	gh-rt	13-18	cyclin D1	Homo sapiens	185-198
26208739-12	2015	Furthermore, the mTOR/p70S6K1 signaling pathway was inhibited in gossypol-treated colon cancer cells, and consequently, cyclin D1 expression was decreased, suggesting an additional mechanism of the observed antiproliferative synergistic interactions.	Gossypol	65-73	cyclin D1	Homo sapiens	120-129
26208739-14	2015	CONCLUSIONS: These findings suggest that gossypol-mediated down-regulation of TS, cyclin D1, and the mTOR/p70S6K1 signaling pathways enhances the anti-tumor effect of 5-FU.	Gossypol	41-49	cyclin D1	Homo sapiens	82-91
26208739-14	2015	CONCLUSIONS: These findings suggest that gossypol-mediated down-regulation of TS, cyclin D1, and the mTOR/p70S6K1 signaling pathways enhances the anti-tumor effect of 5-FU.	Fluorouracil	167-171	cyclin D1	Homo sapiens	82-91
25516376-11	2015	Expression of c-myc and cyclin D1 was significantly decreased by PGD2 ; this inhibitory effect was suppressed by PPARgamma antagonist.	Prostaglandin D2	65-69	cyclin D1	Homo sapiens	24-33
25556515-4	2015	As this fusion results in overexpression of cyclin D1 in ESS, we postulated that overexpression would also occur in CCSK; cyclin D1 immunohistochemistry could then be used to differentiate CCSK from other tumours.	ccsk	116-120	cyclin D1	Homo sapiens	44-53
25556515-4	2015	As this fusion results in overexpression of cyclin D1 in ESS, we postulated that overexpression would also occur in CCSK; cyclin D1 immunohistochemistry could then be used to differentiate CCSK from other tumours.	ccsk	189-193	cyclin D1	Homo sapiens	44-53
25556515-4	2015	As this fusion results in overexpression of cyclin D1 in ESS, we postulated that overexpression would also occur in CCSK; cyclin D1 immunohistochemistry could then be used to differentiate CCSK from other tumours.	ccsk	189-193	cyclin D1	Homo sapiens	122-131
25556515-10	2015	CONCLUSIONS: Cyclin D1 is most helpful in distinguishing CCSK from WT, rhabdoid tumour, and some CMNs, but not from neuroblastoma or Ewing sarcomas.	ccsk	57-61	cyclin D1	Homo sapiens	13-22
26135903-9	2015	To study the molecular mechanism, cell proliferation, invasion and cyclin D1 were inhibited by pre-treatment with 10 microM of PD98059 (ERK(1/2) inhibitor).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	127-134	cyclin D1	Homo sapiens	67-76
26617896-0	2015	CCND1 G870A polymorphism is associated with toxicity of methotrexate in childhood acute lymphoblastic leukemia.	Methotrexate	56-68	cyclin D1	Homo sapiens	0-5
26201988-9	2015	The levels of the cell cycle-related genes and proteins (cyclin D1, cyclin E and CDK2) were reduced by amantadine, and apoptosis was significantly induced.	Amantadine	103-113	cyclin D1	Homo sapiens	57-66
26617896-1	2015	CCND1 plays a key role in cell cycle progression and may cause methotrexate (MTX) resistance, as well as its cytotoxicity.	Methotrexate	63-75	cyclin D1	Homo sapiens	0-5
26617896-1	2015	CCND1 plays a key role in cell cycle progression and may cause methotrexate (MTX) resistance, as well as its cytotoxicity.	Methotrexate	77-80	cyclin D1	Homo sapiens	0-5
26617896-4	2015	We genotyped the CCND1 G870A polymorphism in 125 childhood ALL patients treated with HDMTX.	Methotrexate	85-90	cyclin D1	Homo sapiens	17-22
26617896-7	2015	Our results indicated that the CCND1 G870A polymorphism may be involved in the hepatotoxicity of MTX and act as a biological marker.	Methotrexate	97-100	cyclin D1	Homo sapiens	31-36
26094054-0	2015	The inhibitory mechanism by curcumin on the Zac1-enhanced cyclin D1 expression in human keratinocytes.	Curcumin	28-36	cyclin D1	Homo sapiens	58-67
26094054-3	2015	OBJECTIVES: Since cyclin D1 is a positive regulator for cell-cycle progression and its expression can be inhibited by curcumin, we would like to test whether the expression of cyclin D1 can be affected by Zac1.	Curcumin	118-126	cyclin D1	Homo sapiens	18-27
26094054-4	2015	The cross-talk between curcumin and Zac1 upon the regulation of cyclin D1 expression will also be explored in the HaCaT cell line.	Curcumin	23-31	cyclin D1	Homo sapiens	64-73
26094054-7	2015	RESULTS: Zac1 enhances the expression of cyclin D1, but curcumin decreases both the expression of Zac1 and cyclin D1.	Curcumin	56-64	cyclin D1	Homo sapiens	107-116
26094054-8	2015	Interestingly, Zac1-induced cyclin D1 promoter activity is abolished by curcumin.	Curcumin	72-80	cyclin D1	Homo sapiens	28-37
26094054-11	2015	The experimental results implied that curcumin may inhibit the expression of ZAC, consequently down-regulate the cyclin D1 expression and decelerate cell-cycle progression of psoriatic keratinocytes.	Curcumin	38-46	cyclin D1	Homo sapiens	113-122
26622692-10	2015	Furthermore, cyclin D1 expression was downregulated to 43.7+-17.9% (P&lt;0.05) and 53.2+-18.6% (P&lt;0.05) of the control level in the MIA-Paca2 and PK-45H cell lines, respectively, following treatment with 30 microM SU11274.	((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)	217-224	cyclin D1	Homo sapiens	13-22
26330754-6	2015	This anti-proliferative action of murrayafoline A, arresting cell cycle progression at G0/G1 phase in PDGF-BB-stimulated VSMCs, was mediated via down-regulation of the expression of cyclin D1, cyclin E, cyclin-dependent kinase (CDK)2, CDK4, and proliferating cell nuclear antigen (PCNA), and the phosphorylation of retinoblastoma protein (pRb).	murrayafoline A	34-49	cyclin D1	Homo sapiens	182-191
26094902-9	2015	It was certified that the increase in the amount of NO release, the decrease in the luciferase promoter activity and the expression of cyclin D1 and c-myc in HCT116 cells were affected by aspirin and ISMN in a synergistic manner.	Aspirin	188-195	cyclin D1	Homo sapiens	135-144
26094902-9	2015	It was certified that the increase in the amount of NO release, the decrease in the luciferase promoter activity and the expression of cyclin D1 and c-myc in HCT116 cells were affected by aspirin and ISMN in a synergistic manner.	isosorbide-5-mononitrate	200-204	cyclin D1	Homo sapiens	135-144
26133123-8	2015	The energy metabolism change enhanced AMP-activated protein kinase (AMPK) activation, mTOR repression and downregulation of cyclin D1 and Mcl-1 in response to the mitochondrial inhibitors and biguanides.	Biguanides	192-202	cyclin D1	Homo sapiens	124-133
26622692-12	2015	These results indicated that SU11274 suppresses the proliferation of pancreatic cancer cells via the downregulation of cyclin D1.	((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)	29-36	cyclin D1	Homo sapiens	119-128
26425661-3	2015	Recent studies suggest that PRMT5, which is frequently elevated in human cancers, cooperates with oncogenic cyclin D1 and leaves marks on p53 by way of arginine methylation, promoting the bypass of wild-type p53, and in doing so, evade apoptosis.	Arginine	152-160	cyclin D1	Homo sapiens	108-117
25846733-9	2015	This study suggested that long-term endocrine therapy facilitates leptin and ObRb overexpression in breast cancer cells, which attenuates the inhibitory effect of tamoxifen by activating both the ERK1/2 and STAT3 signaling pathways and upregulating CCND1 gene expression.	Tamoxifen	163-172	cyclin D1	Homo sapiens	249-254
26287365-8	2015	TSA and SAHA promoted apoptosis of SGC-996 cells, down-regulated the expression of cyclin D1, c-Myc and Bmi1, and decreased the phosphorylation of AKT, mTOR p70S6K1, S6 and 4E-BP1.	trichostatin A	0-3	cyclin D1	Homo sapiens	83-92
26203195-3	2015	In addition, our results suggest that activation of the cyclin D1-CDK4 complex by NGP-1 via maintaining the stoichiometry between cyclin D1-CDK4 complex and p21 resulted in hyperphosphorylation of retinoblastoma protein at serine 780 (p-RB(Ser-780)) followed by the up-regulation of E2F1 target genes required to promote G1 to S phase transition.	Serine	223-229	cyclin D1	Homo sapiens	56-65
26203195-3	2015	In addition, our results suggest that activation of the cyclin D1-CDK4 complex by NGP-1 via maintaining the stoichiometry between cyclin D1-CDK4 complex and p21 resulted in hyperphosphorylation of retinoblastoma protein at serine 780 (p-RB(Ser-780)) followed by the up-regulation of E2F1 target genes required to promote G1 to S phase transition.	Serine	240-243	cyclin D1	Homo sapiens	56-65
26244686-4	2015	Sesamin potently inhibited cyclin D1 and CDK4 expression, pRb phosphorylation, and expression of the proliferating cell nuclear antigen (PCNA); and upregulated p27(KIP1), p21(CIP1), and p53.	sesamin	0-7	cyclin D1	Homo sapiens	27-36
26244686-5	2015	The results thus indicate that the antiproliferative effect of sesamin on PDGF-stimulated VSMCs is attributable to arrest of the cell cycle in G0/G1 caused, in turn, by upregulation of p27(KIP1), p21(CIP1), and p53, and inhibition of cyclin E-CDK2 and cyclin D1-CDK4 expression.	sesamin	63-70	cyclin D1	Homo sapiens	252-261
26286725-19	2015	Furthermore, the miR-101 level was inversely correlated with levels of CDK8, beta-catenin, and cyclin D1 in western blotting assay and immunohistochemical staining assay.	mir-101	17-24	cyclin D1	Homo sapiens	95-104
26288223-6	2015	Tauroursodeoxycholic acid, which is known to suppress eIF2alpha phosphorylation, cancelled the effects of EGFR inhibitors on cyclin-D1 expression and cell proliferation in a concentration-dependent manner.	ursodoxicoltaurine	0-25	cyclin D1	Homo sapiens	125-134
26288223-7	2015	The results of an EGFR-silencing study using siRNA showed that gefitinib and erlotinib affected eIF2alpha phosphorylation and cyclin-D1 expression independent of EGFR inhibition.	Gefitinib	63-72	cyclin D1	Homo sapiens	126-135
26288223-7	2015	The results of an EGFR-silencing study using siRNA showed that gefitinib and erlotinib affected eIF2alpha phosphorylation and cyclin-D1 expression independent of EGFR inhibition.	Erlotinib Hydrochloride	77-86	cyclin D1	Homo sapiens	126-135
25946380-10	2015	ATRA not only influenced the cycle procession but also reduced the expression of cyclin D1.	Tretinoin	0-4	cyclin D1	Homo sapiens	81-90
26096843-8	2015	gamma-tocotrienol also reduced PI3K/Akt/mTOR and Ras/MEK/Erk mitogenic signalling, cyclin D1 and cyclin-dependent kinase 4 levels, and increased p27 levels.	plastochromanol 8	0-17	cyclin D1	Homo sapiens	83-92
26119846-5	2015	Thonningianin A induced cell cycle arrest by changing the cyclin D1 and CDK4 mRNA expression levels.	thonningianin A	0-15	cyclin D1	Homo sapiens	58-67
26060089-8	2015	Cisplatin also blocked the progression of the cell cycle in the G0/G1 phase, which inhibited cyclin D1 and induced apoptosis.	Cisplatin	0-9	cyclin D1	Homo sapiens	93-102
25736800-0	2015	EGF Protects Cells Against Dox-Induced Growth Arrest Through Activating Cyclin D1 Expression.	Doxorubicin	27-30	cyclin D1	Homo sapiens	72-81
25736800-4	2015	Utilizing real-time PCR and western blotting analysis, we found that the expression of the cell cycle-associated protein cyclin D1 was inhibited in GATA-4-silenced cells and Dox-treated cells and was enhanced in GATA-4 over-expressing cells and EGF-treated cells.	Doxorubicin	174-177	cyclin D1	Homo sapiens	121-130
25736800-5	2015	Furthermore, EGF treatment reversed the inhibited expression of cyclin D1 that was mediated by GATA-4 RNAi or Dox.	Doxorubicin	110-113	cyclin D1	Homo sapiens	64-73
26015296-10	2015	Octreotide not only reversed everolimus-induced Akt phosphorylation but also displayed additive and complementary effects with everolimus on downstream proteins involved in translation (4EB-P1), and controlling cell cycle (p27Kip1 and cyclin D1).	Octreotide	0-10	cyclin D1	Homo sapiens	235-244
26015296-10	2015	Octreotide not only reversed everolimus-induced Akt phosphorylation but also displayed additive and complementary effects with everolimus on downstream proteins involved in translation (4EB-P1), and controlling cell cycle (p27Kip1 and cyclin D1).	Everolimus	127-137	cyclin D1	Homo sapiens	235-244
25280667-6	2015	TCE treatment was seen to arrest the majority of cells in G0/G1 phase and modulated the expression of DNA clamp sliding protein (PCNA) and cyclin D1.	Trichloroethylene	0-3	cyclin D1	Homo sapiens	139-148
26434118-5	2015	The levels of cyclin D1 and cyclin B1 were determined by means of Western blot in all cell lines incubated with quercetin (50 muM) for 48 hours.	Quercetin	112-121	cyclin D1	Homo sapiens	14-23
26434118-6	2015	The cyclin D1 expression was significantly decreased following the treatment with quercetin in SKOV3 and U2OSPt cells, but not in SKOV3/CDDP and U2OS cells.	Quercetin	82-91	cyclin D1	Homo sapiens	4-13
26434118-7	2015	The reduction of cyclin D1 level could be linked to the G1/S phase alteration found in quercetin-treated cells.	Quercetin	87-96	cyclin D1	Homo sapiens	17-26
25854169-5	2015	Cyclin D1 and c-Myc are important regulators of cancer cell growth, and we observed that treatment of thyroid cancer cells with metformin reduced c-Myc and cyclin D1 expression through suppression of mTOR and subsequent inhibition of P70S6K1 and 4E-BP1 phosphorylation.	Metformin	128-137	cyclin D1	Homo sapiens	0-9
25854169-5	2015	Cyclin D1 and c-Myc are important regulators of cancer cell growth, and we observed that treatment of thyroid cancer cells with metformin reduced c-Myc and cyclin D1 expression through suppression of mTOR and subsequent inhibition of P70S6K1 and 4E-BP1 phosphorylation.	Metformin	128-137	cyclin D1	Homo sapiens	156-165
25910917-6	2015	When cell death was induced by UA, it was found that the expression of beta-catenin, c-Myc and Cyclin D1 were decreased and TCF/LEF transcriptional activation was notably down-regulated.	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one	31-33	cyclin D1	Homo sapiens	95-104
26287365-8	2015	TSA and SAHA promoted apoptosis of SGC-996 cells, down-regulated the expression of cyclin D1, c-Myc and Bmi1, and decreased the phosphorylation of AKT, mTOR p70S6K1, S6 and 4E-BP1.	Vorinostat	8-12	cyclin D1	Homo sapiens	83-92
26124325-11	2015	We demonstrated a statistically significant lapatinib- and gefitinib-induced repression of cyclin D1, MMP9 and beta-catenin in CERV196 cells dependent on incubation time.	Lapatinib	44-53	cyclin D1	Homo sapiens	91-100
26196392-7	2015	Most importantly, the up-regulation of AMPK, p53, p21CIP1, p27KIP1 and the down-regulation of cyclinD1 are involved in the anti-tumor action of metformin in vivo.	Metformin	144-153	cyclin D1	Homo sapiens	94-102
26196392-9	2015	AMPK, p53, p21CIP1, p27KIP1 and cyclinD1 are involved in the inhibition of tumor growth that is induced by metformin and cell cycle arrest in ESCC.	Metformin	107-116	cyclin D1	Homo sapiens	32-40
26124325-11	2015	We demonstrated a statistically significant lapatinib- and gefitinib-induced repression of cyclin D1, MMP9 and beta-catenin in CERV196 cells dependent on incubation time.	Gefitinib	59-68	cyclin D1	Homo sapiens	91-100
26124325-12	2015	CONCLUSION: Cyclin D1 and MMP9 expression profiles may represent an early measure of sensitivity and level of response to lapatinib and gefitinib.	Lapatinib	122-131	cyclin D1	Homo sapiens	12-21
26124325-12	2015	CONCLUSION: Cyclin D1 and MMP9 expression profiles may represent an early measure of sensitivity and level of response to lapatinib and gefitinib.	Gefitinib	136-145	cyclin D1	Homo sapiens	12-21
26157550-0	2015	Anti-Proliferative Effect of Naringenin through p38-Dependent Downregulation of Cyclin D1 in Human Colorectal Cancer Cells.	naringenin	29-39	cyclin D1	Homo sapiens	80-89
26157550-5	2015	Inhibition of proteasomal degradation by MG132 blocked NAR-mediated cyclin D1 downregulation and the half-life of cyclin D1 was decreased in the cells treated with NAR.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	41-46	cyclin D1	Homo sapiens	68-77
26211581-3	2015	XN treatment was found to induce cell cycle arrest and apoptosis of PC cells (PANC-1, BxPC-3) by inhibiting phosphorylation of signal transducer and activator of transcription 3 (STAT3) and expression of its downstream targeted genes cyclinD1, survivin, and Bcl-xL at the messenger RNA level, which involved in regulation of apoptosis and the cell cycle.	xanthohumol	0-2	cyclin D1	Homo sapiens	234-242
26157550-6	2015	In addition, NAR increased the phosphorylation of cyclin D1 at threonine-286 and a point mutation of threonine-286 to alanine blocked cyclin D1 downregulation by NAR.	Threonine	63-72	cyclin D1	Homo sapiens	50-59
26307847-6	2015	Moreover, the expression of the cell cycle protein cyclin D1 was dramatically inhibited by simvastatin in both cells, with simvastatin-loaded star-shaped CA-PLGA nanoparticles having the greatest effect.	Simvastatin	91-102	cyclin D1	Homo sapiens	51-60
26339357-8	2015	Furthermore, methylprednisolone could inhibit LEF-1 protein expression, consequently down-regulate mRNA levels of c-myc and cyclin D1, but could not affect the transcription level of beta-catenin and LEF-1 mRNA.	Methylprednisolone	13-31	cyclin D1	Homo sapiens	124-133
26307847-6	2015	Moreover, the expression of the cell cycle protein cyclin D1 was dramatically inhibited by simvastatin in both cells, with simvastatin-loaded star-shaped CA-PLGA nanoparticles having the greatest effect.	Simvastatin	123-134	cyclin D1	Homo sapiens	51-60
25738885-5	2015	Furthermore, the present study observed that DS/Cu may inhibit proliferation via inhibition of AKT and cyclin D1 signaling and promote apoptosis via c-Jun N-terminal kinase activation and suppression of nuclear factor kappaB signaling.	Deuterium	45-47	cyclin D1	Homo sapiens	103-112
25738885-5	2015	Furthermore, the present study observed that DS/Cu may inhibit proliferation via inhibition of AKT and cyclin D1 signaling and promote apoptosis via c-Jun N-terminal kinase activation and suppression of nuclear factor kappaB signaling.	Copper	48-50	cyclin D1	Homo sapiens	103-112
25738368-5	2015	In addition, simvastatin arrested cells in the G0/G1 phase of the cell cycle, downregulated the protein expression levels of cyclin D1 and cyclin-dependent kinase (CDK)2, mediated the mitochondria-dependent caspase cascade by increasing the protein expression levels of caspase-3, -8 and -9, and downregulated the protein expression of X-linked inhibitor of apoptosis, which induced cell apoptosis.	Simvastatin	13-24	cyclin D1	Homo sapiens	125-134
25751590-9	2015	Cyclin D1 immunohistochemistry helps distinguish CCSK from blastemal WT and metanephric adenoma and rhabdoid tumors, but not from neuroblastomas and mesoblastic nephromas.	ccsk	49-53	cyclin D1	Homo sapiens	0-9
25738368-7	2015	Taken together, these results demonstrated that the antitumor effect of simvastatin in the human MDA-MB-231 breast cancer cell line was via the inhibition of cell proliferation, affecting the cell cycle, downregulating the expression levels of cyclin D1 and CDKs, inducing apoptosis and decreasing the expression of MMP-2, possibly by inhibiting the activation of NF-kappaB.	Simvastatin	72-83	cyclin D1	Homo sapiens	244-262
25779425-11	2015	Thus, EV71 regulated the host SH-SY5Y cell cycle and cell proliferation via stimulating endo-genous miRNA let-7b and directly targeting CCND1, therefore EV71 is a potential candidate for antiviral therapy.	ev71	6-10	cyclin D1	Homo sapiens	136-141
25779425-11	2015	Thus, EV71 regulated the host SH-SY5Y cell cycle and cell proliferation via stimulating endo-genous miRNA let-7b and directly targeting CCND1, therefore EV71 is a potential candidate for antiviral therapy.	ev71	153-157	cyclin D1	Homo sapiens	136-141
25751590-10	2015	Cyclin D1 overexpression in CCSK is not contingent on YWHAE-FAM22 translocation, and cyclin D1 inhibition may potentially be explored as a targeted therapeutic strategy in CCSK.	ccsk	28-32	cyclin D1	Homo sapiens	0-9
26085034-6	2015	Individuals over 50 years of age and those with high dietary arginine consumption had increased basal expression of CyclinD1, AXIN2, cMYC and CD133 (p value range 0   04 to &lt;0   001) that, following grape ingestion, were reduced to levels seen in younger participants.The reduction in Wnt signaling and mucosal proliferation seen following short-term ingestion of 1/3-1 lb (0.15-0.45 kg) of grapes per day may reduce the risk of mutational events that can facilitate colon carcinogenesis.	Arginine	61-69	cyclin D1	Homo sapiens	116-124
26121043-0	2015	Resibufogenin Induces G1-Phase Arrest through the Proteasomal Degradation of Cyclin D1 in Human Malignant Tumor Cells.	bufogenin	0-13	cyclin D1	Homo sapiens	77-86
26121043-5	2015	Here we report that resibufogenin induces G1-phase arrest with hypophosphorylation of retinoblastoma (RB) protein and down-regulation of cyclin D1 expression in human colon cancer HT-29 cells.	bufogenin	20-33	cyclin D1	Homo sapiens	137-146
26121043-6	2015	Since the down-regulation of cyclin D1 was completely blocked by a proteasome inhibitor MG132, the suppression of cyclin D1 expression by resibufogenin was considered to be in a proteasome-dependent manner.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	88-93	cyclin D1	Homo sapiens	29-38
26121043-6	2015	Since the down-regulation of cyclin D1 was completely blocked by a proteasome inhibitor MG132, the suppression of cyclin D1 expression by resibufogenin was considered to be in a proteasome-dependent manner.	bufogenin	138-151	cyclin D1	Homo sapiens	29-38
26121043-6	2015	Since the down-regulation of cyclin D1 was completely blocked by a proteasome inhibitor MG132, the suppression of cyclin D1 expression by resibufogenin was considered to be in a proteasome-dependent manner.	bufogenin	138-151	cyclin D1	Homo sapiens	114-123
26121043-8	2015	The addition of GSK-3beta inhibitor SB216763 inhibited the reduction of cyclin D1 caused by resibufogenin.	SB 216763	36-44	cyclin D1	Homo sapiens	72-81
26121043-9	2015	These effects on cyclin D1 by resibufogenin were also observed in human lung cancer A549 cells.	bufogenin	30-43	cyclin D1	Homo sapiens	17-26
26309628-8	2015	As expected, curcumin inhibited IL-22 induced phosphorylation of STAT3; furthermore, curcumin down regulated cyclin D1 and cyclin E. We can reach a conclusion that curcumin can suppress the proliferation of keratinocytes even with IL-22 treatment.	Curcumin	13-21	cyclin D1	Homo sapiens	109-118
26309628-8	2015	As expected, curcumin inhibited IL-22 induced phosphorylation of STAT3; furthermore, curcumin down regulated cyclin D1 and cyclin E. We can reach a conclusion that curcumin can suppress the proliferation of keratinocytes even with IL-22 treatment.	Curcumin	85-93	cyclin D1	Homo sapiens	109-118
26309628-8	2015	As expected, curcumin inhibited IL-22 induced phosphorylation of STAT3; furthermore, curcumin down regulated cyclin D1 and cyclin E. We can reach a conclusion that curcumin can suppress the proliferation of keratinocytes even with IL-22 treatment.	Curcumin	85-93	cyclin D1	Homo sapiens	109-118
25714087-5	2015	Results show that chabamide inhibited the growth of K562/ADR cells in a dose-dependent and time-dependent manner, and significantly inhibited cell proliferation by cell cycle arrest in the G0/G1 phase, which was associated with an obvious increase in p21 and decrease in cyclin D1 and CDK2/4/6 protein expression.	chabamide	18-27	cyclin D1	Homo sapiens	271-280
26043725-15	2015	Butyrate increased levels of cyclin D1, p21 and PARP p86, but decreased Bcl-XL and survivin levels.	Butyrates	0-8	cyclin D1	Homo sapiens	29-38
25840985-5	2015	Ormeloxifene caused potent inhibition of the SHH signaling pathway via downregulation of SHH and its related important downstream targets such as Gli-1, SMO, PTCH1/2, NF-kappaB, p-AKT, and cyclin D1.	ormeloxifene	0-12	cyclin D1	Homo sapiens	189-198
26073339-7	2015	Compared with the control cells, the expression levels of the cell cycle regulatory proteins cyclin D1/D2/D3, cyclin E1, CDK2/4/6 (CDK: cyclin dependent kinase), and p-Rb were decreased significantly in the cells treated with MTE at 40 mg mL(-1).	methylthioethanol	226-229	cyclin D1	Homo sapiens	93-102
26221477-8	2015	RESULTS: Juglone significantly inhibited SKOV3 cell proliferation as shown by G0/G1 phase arrest, and this effect was mediated by inactivation of cyclin D1 protein (P&lt;0.05).	juglone	9-16	cyclin D1	Homo sapiens	146-155
26261511-6	2015	Ectopic expression of miR-135a led to downregulation of the FOXO1 protein, resulting in upregulation of Cyclin D1, and downregulation of P21(Cip1) and P27(Kip1) through AKT pathway.	mir-135a	22-30	cyclin D1	Homo sapiens	104-113
26151043-6	2015	Notably, esculetin modulated Sp1 downstream target genes including p27, p21 and cyclin D1, resulted in activation of apoptosis signaling molecules such as caspase-3 and PARP in G361 HMM cells.	esculetin	9-18	cyclin D1	Homo sapiens	80-89
25845399-4	2015	We found that the proliferation of PC3 cells, as determined using the MTT assay, and the expression of cyclin D1, COX-2, Bcl-2 and survivin proteins elevated by LPS were distinctly inhibited by sesamin in a dose-dependent manner.	sesamin	194-201	cyclin D1	Homo sapiens	103-112
26016774-5	2015	The chromatin immunoprecipitation assay showed the association of sHB-EGF-EGFR complex with promoter region of cyclin D1 in the cell nucleus and this association was prevented by application of EGFR kinase inhibitor AG-1478.	RTKI cpd	216-223	cyclin D1	Homo sapiens	111-120
26137139-0	2015	miR-218 inhibits the proliferation of glioma U87 cells through the inactivation of the CDK6/cyclin D1/p21Cip1/Waf1 pathway.	mir-218	0-7	cyclin D1	Homo sapiens	92-101
26137139-8	2015	The present results suggest that miR-218 plays an important role in the prevention of the proliferation of glioma cells, and the present study also revealed a novel mechanism for miRNA-mediated direct suppression of the CDK6/cyclin D1/p21Cip1/Waf1 pathway in glioma cells.	mir-218	33-40	cyclin D1	Homo sapiens	225-234
26310342-8	2015	RESULTS: As compared to the control group (1.00 +- 0.08), the expression of CyclinD1 (2.99 +- 0.15), KI67 (2.35 +- 0.38) and PCNA (2.46 +- 0.25) in HET-1A were all markedly increased by NMBzA treatment (F values were 97.23, 65.28, 34.62, P &lt; 0.001).	nitrosobenzylmethylamine	186-191	cyclin D1	Homo sapiens	76-84
25921811-5	2015	GRM7 regulates the phosphorylation of cyclic AMP response element-binding protein (CREB) and the expression of Yes-associated protein (YAP) by directly interacting with CaM, which subsequently regulates the expression of CyclinD1 and ultimately affects early cortical development.	cafestol palmitate	169-172	cyclin D1	Homo sapiens	221-229
25849888-6	2015	Interestingly, we found that c-myc and cyclin D1 increased significantly in transfected cells with increasing PTX concentration, and cell-survival rates remained at 60% while the PTX concentration increased.	Paclitaxel	110-113	cyclin D1	Homo sapiens	39-48
25849888-6	2015	Interestingly, we found that c-myc and cyclin D1 increased significantly in transfected cells with increasing PTX concentration, and cell-survival rates remained at 60% while the PTX concentration increased.	Paclitaxel	179-182	cyclin D1	Homo sapiens	39-48
25869100-5	2015	Expression of TCF-1 and beta-catenin-responsive proteins, c-Myc and cyclin D1 also decreased in response to capsaicin treatment.	Capsaicin	108-117	cyclin D1	Homo sapiens	68-77
25946558-7	2015	TBBX induced Hsp90 hyper-acetylation and led to the disruption of cyclin D1/Hsp90 and CDK4/Hsp90 association following the degradation of cyclin D1 and CDK4 proteins through proteasome.	tbbx	0-4	cyclin D1	Homo sapiens	138-147
26309548-5	2015	The expression levels of Cyclin A, CDK2, and Cyclin D1 were downregulated by baicalin treatment.	baicalin	77-85	cyclin D1	Homo sapiens	45-54
25946558-9	2015	Conclusively, the data suggested that TBBX induced G1 growth arrest may mediate HDAC6-caused Hsp90 hyper-acetylation and consequently increased the degradation of cyclin D1 and CDK4.	tbbx	38-42	cyclin D1	Homo sapiens	163-172
25735758-7	2015	Wnt signaling could be activated in DPSCs after Lithium or Wnt-1 treatment, as shown by accumulation of beta-catenin, its translocation into the nucleus and enhanced expression of key pathway players, like LEF1 and Cyclin D1.	Lithium	48-55	cyclin D1	Homo sapiens	215-224
25537422-7	2015	CaeA caused cell cycle arrest by (i) inhibiting ribonucleotide reductase (RNR) enzyme, which catalyses the rate-limiting step in the synthesis of DNA; (ii) stimulating MAPKs signalling transduction pathways that play an important role in cell growth, proliferation and differentiation; and (iii) by targeting cell cycle control molecules such as cyclin D1, cyclin-dependent kinase 4 and p21(CIP1/WAF1) .	caerulomycin A	0-4	cyclin D1	Homo sapiens	346-355
26109759-8	2015	In silico docking interaction of the 14 active components (identified by high-performance liquid chromatography/gas chromatography-mass spectroscopy) of the methanol extract was tested with cyclin D1 (Protein Data Bank ID: 2W96) and compared with the reference cyclin D1/Cdk4 inhibitor.	Methanol	157-165	cyclin D1	Homo sapiens	190-199
25776829-7	2015	In addition, quercetin aglycone and PAC DP-9 deactivated MAPK-ERK pathway, induced downregulation of cyclin D1, DNA-PK, phospho-histone H3 and upregulation of p21, and arrested cell cycle progression.	quercetin aglycone	13-31	cyclin D1	Homo sapiens	101-110
25597476-6	2015	In addition, the expressions of cyclin-dependent kinase 4 (CDK4), CDK6, cyclin D3, and cyclin D1 were downregulated by alantolactone.	alantolactone	119-132	cyclin D1	Homo sapiens	87-96
26109759-8	2015	In silico docking interaction of the 14 active components (identified by high-performance liquid chromatography/gas chromatography-mass spectroscopy) of the methanol extract was tested with cyclin D1 (Protein Data Bank ID: 2W96) and compared with the reference cyclin D1/Cdk4 inhibitor.	Methanol	157-165	cyclin D1	Homo sapiens	261-270
25625870-4	2015	DCL and CL suppressed cyclin D1 and survivin through inhibiting nuclear translocation of beta-catenin.	dehydrocostus lactone	0-3	cyclin D1	Homo sapiens	22-31
25908095-6	2015	Conversely, MAPK/p38 inactivation or REGgamma deletion prevents the increase of cyclinD1 and c-Myc by TPA.	Tetradecanoylphorbol Acetate	102-105	cyclin D1	Homo sapiens	80-88
25858474-4	2015	Our results showed that ESR2 overexpression in the presence of 10-8 M 17-beta-estradiol downregulated c-myc and cyclin D1 expression and simultaneously upregulated p27 expression.	Estradiol	70-87	cyclin D1	Homo sapiens	112-121
25871400-6	2015	In addition, activated FOXO3a disturbed the interaction between beta-catenin and TCF and inhibited the expression of beta-catenin/TCF target genes (ZEB1, c-Myc and CyclinD1), which played important roles in doxorubicin-induced EMT in HCC cells.	Doxorubicin	207-218	cyclin D1	Homo sapiens	164-172
25925673-13	2015	However, CCND1 expression was lower in tumors responding to atorvastatin treatment with a decrease in proliferation although not significantly (P = 0.08).	Atorvastatin	60-72	cyclin D1	Homo sapiens	9-14
25898413-7	2015	Moreover, treatment with PD98059, a highly selective ERK inhibitor, blocked PDGF-induced upregulation of cyclin D1 and cyclin E and downregulation of p27kip1.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	25-32	cyclin D1	Homo sapiens	105-114
25691730-8	2015	Caffeine significantly reduced ER and cyclin D1 abundance in ER(+) cells.	Caffeine	0-8	cyclin D1	Homo sapiens	38-47
25945059-8	2015	Arsenic trioxide treatment also reduced Gli1 downstream target gene expression, such as Bcl2 and CCND1.	Arsenic Trioxide	0-16	cyclin D1	Homo sapiens	97-102
25897210-12	2015	Treatment of CQ and NQ repressed expression of cyclin D1 but enhanced expression of p21.	Clioquinol	13-15	cyclin D1	Homo sapiens	47-56
25897210-12	2015	Treatment of CQ and NQ repressed expression of cyclin D1 but enhanced expression of p21.	nq	20-22	cyclin D1	Homo sapiens	47-56
25721973-1	2015	Crispene E, a new clerodane-type diterpene, inhibited STAT3 dimerization in a cell-free fluorescent polarisation assay and was found to have significant toxicity against STAT3-dependent MDA-MB 231 breast cancer cell line and selectively inhibited the expression of STAT3 and STAT3 target genes cyclin D1, Fascin and bcl-2.	crispene E	0-10	cyclin D1	Homo sapiens	294-303
25837691-13	2015	Treated BCCs expressed cyclin D1 on TCP and fibrous scaffolds during the 7-day culture period.	tcp	36-39	cyclin D1	Homo sapiens	23-32
25960215-5	2015	Furthermore, we demonstrated that miR-194 could reduce the phosphoinositide 3-kinase (PI3K)/AKT/FoxO3a signaling pathway by suppressing acylglycerol kinase (AGK) directly, resulting in decreasing cyclin D1 expression and increasing expression of p21 in OSCC.	mir-194	34-41	cyclin D1	Homo sapiens	196-205
25611086-7	2015	Ginkgetin induced STAT3 dephosphorylation at Try705 and inhibited its localization to the nucleus, leading to the inhibition of expression of STAT3 target genes such as cell survival-related genes (cyclin D1 and survivin) and anti-apoptotic proteins (Bcl-2 and Bcl-xL).	ginkgetin	0-9	cyclin D1	Homo sapiens	198-207
25672876-7	2015	Resveratrol inhibited cyclin D1 synthesis, whereas it stimulated p21WAF1/CIP1 (p21) and p27KIP1 (p27) synthesis.	Resveratrol	0-11	cyclin D1	Homo sapiens	22-31
25434397-7	2015	In addition, the expression of p53, cyclin D1 and CDK2 was altered following DCA treatment.	Deoxycholic Acid	77-80	cyclin D1	Homo sapiens	36-45
25515619-5	2015	Cell cycle analysis revealed that resveratrol may induce cell cycle arrest in the G0/G1 phase by downregulating the expression levels of cyclin D1, cyclin-dependent kinase (CDK)4 and CDK6, and upregulating the expression levels of the CDK inhibitors, p21 and p27.	Resveratrol	34-45	cyclin D1	Homo sapiens	137-146
25739982-0	2015	mTOR is involved in 17beta-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1, and CCNE1.	Estradiol	20-36	cyclin D1	Homo sapiens	135-140
25739982-7	2015	Rapamycin suppressed 17beta-estradiol-induced Sertoli cell proliferation, appearing to act by reducing the abundance of SKP2, CCND1, and CCNE1 mRNA as well as RB and EMI1 protein.	Sirolimus	0-9	cyclin D1	Homo sapiens	126-131
25739982-7	2015	Rapamycin suppressed 17beta-estradiol-induced Sertoli cell proliferation, appearing to act by reducing the abundance of SKP2, CCND1, and CCNE1 mRNA as well as RB and EMI1 protein.	Estradiol	21-37	cyclin D1	Homo sapiens	126-131
25907934-9	2015	Thioridazine treatment of the cells resulted in up-regulated PDCD4 mRNA expression and down-regulated mRNA expressions of CCND1, CDK4, c-MYC, BCL2, CASPASE3, PARP1 and EIF4A, increased PDCD4 protein expression and reduced p-AKT protein expression.	Thioridazine	0-12	cyclin D1	Homo sapiens	122-127
25633416-9	2015	FOXM1 effector genes such as CDK4, p53 and cyclin D1 were downregulated in gastric cancer cells by combination treatment with DIM and paclitaxel.	3,3'-diindolylmethane	126-129	cyclin D1	Homo sapiens	43-52
25633416-9	2015	FOXM1 effector genes such as CDK4, p53 and cyclin D1 were downregulated in gastric cancer cells by combination treatment with DIM and paclitaxel.	Paclitaxel	134-144	cyclin D1	Homo sapiens	43-52
25946558-5	2015	Furthermore, the protein levels of cyclin D1, CDK2 and CDK4 were reduced while cyclin E and CDK inhibitor, p21Waf1/Cip1, were up-regulated in TBBX-treated H1299 cells.	tbbx	142-146	cyclin D1	Homo sapiens	35-44
25946558-7	2015	TBBX induced Hsp90 hyper-acetylation and led to the disruption of cyclin D1/Hsp90 and CDK4/Hsp90 association following the degradation of cyclin D1 and CDK4 proteins through proteasome.	tbbx	0-4	cyclin D1	Homo sapiens	66-75
25815723-6	2015	In addition, the up-regulation of EGR-1 by nicotine can also increase the phosphorylation of CyclinD1 which contributes to the attenuation of amyloid-beta (Abeta(25-35)) -induced neurotoxicity.	Nicotine	43-51	cyclin D1	Homo sapiens	93-101
25040852-6	2015	Stimulation of AR by dihydrotestosterone in OSCC cells caused an increase in cyclin D1 expression and promoted cell growth, whereas treatment with bicalutamide led to decreased cyclin D1 expression and inhibited cell growth.	Dihydrotestosterone	21-40	cyclin D1	Homo sapiens	77-86
25040852-6	2015	Stimulation of AR by dihydrotestosterone in OSCC cells caused an increase in cyclin D1 expression and promoted cell growth, whereas treatment with bicalutamide led to decreased cyclin D1 expression and inhibited cell growth.	bicalutamide	147-159	cyclin D1	Homo sapiens	177-186
25416439-6	2015	Both sorafenib and ATO downregulated the expression of cyclin D1, resulting in HCC cells arrested at G0/G1 phase.	Sorafenib	5-14	cyclin D1	Homo sapiens	55-64
25686711-6	2015	Analysis of the underlying mechanism showed that 6-S and PTE decreased the expression of the surface antigen CD44 on BCSCs and promoted beta-catenin phosphorylation through the inhibition of hedgehog/Akt/GSK3beta signaling, thus decreasing the protein expression of downstream c-Myc and cyclin D1 and reducing BCSC stemness.	shogaol	49-52	cyclin D1	Homo sapiens	287-296
25416439-6	2015	Both sorafenib and ATO downregulated the expression of cyclin D1, resulting in HCC cells arrested at G0/G1 phase.	Arsenic Trioxide	19-22	cyclin D1	Homo sapiens	55-64
25811972-5	2015	Importantly, flubendazole reduced CD44high/CD24low subpopulation and suppressed the formation of mammosphere and the expression of self-renewal related genes including c-myc, oct4, sox2, nanog and cyclinD1.	flubendazole	13-25	cyclin D1	Homo sapiens	197-205
25786122-7	2015	Expression of downstream effectors of TGF-beta signaling pathway, cyclinD1, p21 and Pin1, was inhibited along with the down regulation of key mesenchymal markers (Snail and Slug) upon curcumin and emodin treatment.	Curcumin	184-192	cyclin D1	Homo sapiens	66-74
25686711-6	2015	Analysis of the underlying mechanism showed that 6-S and PTE decreased the expression of the surface antigen CD44 on BCSCs and promoted beta-catenin phosphorylation through the inhibition of hedgehog/Akt/GSK3beta signaling, thus decreasing the protein expression of downstream c-Myc and cyclin D1 and reducing BCSC stemness.	pterostilbene	57-60	cyclin D1	Homo sapiens	287-296
25762616-3	2015	We found that garcinol inhibited the viability of a panel of diverse HNSCC cell lines, enhanced the apoptotic effect of cisplatin, suppressed constitutive as well as cisplatin-induced NF-kappaB activation, and downregulated the expression of various oncogenic gene products (cyclin D1, Bcl-2, survivin and VEGF).	garcinol	14-22	cyclin D1	Homo sapiens	275-284
25686822-5	2015	Furthermore, canertinib and afatinib treatment also inhibited proliferation, migration and survival of pancreatic cancer cells by attenuation of signaling events including pERK1/2 (T202/Y204), cyclin D1, cyclin A, pFAK (Y925) and pAKT (Ser473).	Canertinib	13-23	cyclin D1	Homo sapiens	193-202
25686822-5	2015	Furthermore, canertinib and afatinib treatment also inhibited proliferation, migration and survival of pancreatic cancer cells by attenuation of signaling events including pERK1/2 (T202/Y204), cyclin D1, cyclin A, pFAK (Y925) and pAKT (Ser473).	Afatinib	28-36	cyclin D1	Homo sapiens	193-202
25744297-4	2015	Scoparone markedly reduced the serum-stimulated accumulation of cells in the S phase and concomitantly increased the proportion of cells in the G0/G1 phase, which was consistent with the reduced expression of cyclin D1, phosphorylated Rb and survivin in the VSMCs.	scoparone	0-9	cyclin D1	Homo sapiens	209-218
25817345-11	2015	We further revealed that Pim&amp;mdash;3 knockdown induced growth inhibition by reducing the levels of the anti&amp;mdash;apoptotic protein Bcl&amp;mdash;xl and cell cycle regulatory proteins, including cyclin D1 and Cdc25C, and increasing the levels of the pro&amp;mdash;apoptotic protein Bax.	Adenosine Monophosphate	29-32	cyclin D1	Homo sapiens	203-212
25817345-11	2015	We further revealed that Pim&amp;mdash;3 knockdown induced growth inhibition by reducing the levels of the anti&amp;mdash;apoptotic protein Bcl&amp;mdash;xl and cell cycle regulatory proteins, including cyclin D1 and Cdc25C, and increasing the levels of the pro&amp;mdash;apoptotic protein Bax.	Adenosine Monophosphate	112-115	cyclin D1	Homo sapiens	203-212
25817345-11	2015	We further revealed that Pim&amp;mdash;3 knockdown induced growth inhibition by reducing the levels of the anti&amp;mdash;apoptotic protein Bcl&amp;mdash;xl and cell cycle regulatory proteins, including cyclin D1 and Cdc25C, and increasing the levels of the pro&amp;mdash;apoptotic protein Bax.	Adenosine Monophosphate	112-115	cyclin D1	Homo sapiens	203-212
26204392-0	2015	Cyclic phosphatidic acid induces G0/G1 arrest, inhibits AKT phosphorylation, and downregulates cyclin D1 expression in colorectal cancer cells.	cyclic phosphatidic acid	0-24	cyclin D1	Homo sapiens	95-104
25661319-11	2015	Pretreatment with Z-FY-CHO (a selective cathepsin L inhibitor), or knockdown of cathepsin L significantly attenuated IR-induced nuclear translocation of NF-kappaB and cyclin D1 and ATM transactivation, and sensitized the cells to IR.	N-(benzyloxycarbonyl)-phenylalanyl-tyrosinal	18-26	cyclin D1	Homo sapiens	167-176
26204392-8	2015	Our findings indicate that cPA inhibits cell cycle progression in DLD-1 colon cancer cells via the downregulation of cyclin D1 and the inhibition of AKT phosphorylation.	cpa	27-30	cyclin D1	Homo sapiens	117-126
26045752-9	2015	Our results also showed that miR-196a mimic accelerated cell cycle progression of MG63 and U2OS cells by down regulation of p21 and p27, and upregulation of cyclin D1.	mir-196a	29-37	cyclin D1	Homo sapiens	157-166
25615593-0	2015	Tanshinone I induces cyclin D1 proteasomal degradation in an ERK1/2 dependent way in human colorectal cancer cells.	tanshinone	0-12	cyclin D1	Homo sapiens	21-30
25615593-6	2015	Inhibition of proteasomal degradation by MG132 blocked TAN I-mediated cyclin D1 downregulation and the half-life of cyclin D1 was decreased in the cells treated with TAN I.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	41-46	cyclin D1	Homo sapiens	70-79
25615593-7	2015	In addition, phosphorylation of cyclin D1 at threonine-286 was increased by TAN I and a point mutation of threonine-286 to alanine attenuated TAN I-mediated cyclin D1 downregulation.	Threonine	45-54	cyclin D1	Homo sapiens	32-41
25615593-7	2015	In addition, phosphorylation of cyclin D1 at threonine-286 was increased by TAN I and a point mutation of threonine-286 to alanine attenuated TAN I-mediated cyclin D1 downregulation.	Threonine	45-54	cyclin D1	Homo sapiens	157-166
25615593-9	2015	From these results, we suggest that TAN I-mediated cyclin D1 downregulation may result from proteasomal degradation through its ERK1/2-mediated phosphorylation of threonine-286.	Threonine	163-172	cyclin D1	Homo sapiens	51-60
25617735-8	2015	Inhibition of cyclinD1 decreased the cell viability assessed by MTT and increased rate of apoptosis when exposed to 5-FU treatment while overexpression of cyclinD1 showed the reverse effect.	monooxyethylene trimethylolpropane tristearate	64-67	cyclin D1	Homo sapiens	14-22
26011354-9	2015	Rapamycin induced autophagy, increased the expression of p27 and decreased the expression of Cyclin D1.	Sirolimus	0-9	cyclin D1	Homo sapiens	93-102
25470788-6	2015	The survival in patients with Cyclin D1 G870A polymorphism Adenine/Adenine was 15.1 months (95% CI 11.3-18.9), 21.5 months (17.4-25.6) for Adenine/Guanine, and 29.4 months (95% CI 23.8-35.0) for Guanine/Guanine (P = 0.003).	Adenine	59-66	cyclin D1	Homo sapiens	30-39
25470788-6	2015	The survival in patients with Cyclin D1 G870A polymorphism Adenine/Adenine was 15.1 months (95% CI 11.3-18.9), 21.5 months (17.4-25.6) for Adenine/Guanine, and 29.4 months (95% CI 23.8-35.0) for Guanine/Guanine (P = 0.003).	Adenine	67-74	cyclin D1	Homo sapiens	30-39
25470788-6	2015	The survival in patients with Cyclin D1 G870A polymorphism Adenine/Adenine was 15.1 months (95% CI 11.3-18.9), 21.5 months (17.4-25.6) for Adenine/Guanine, and 29.4 months (95% CI 23.8-35.0) for Guanine/Guanine (P = 0.003).	Adenine	67-74	cyclin D1	Homo sapiens	30-39
25470788-6	2015	The survival in patients with Cyclin D1 G870A polymorphism Adenine/Adenine was 15.1 months (95% CI 11.3-18.9), 21.5 months (17.4-25.6) for Adenine/Guanine, and 29.4 months (95% CI 23.8-35.0) for Guanine/Guanine (P = 0.003).	Guanine	147-154	cyclin D1	Homo sapiens	30-39
25470788-6	2015	The survival in patients with Cyclin D1 G870A polymorphism Adenine/Adenine was 15.1 months (95% CI 11.3-18.9), 21.5 months (17.4-25.6) for Adenine/Guanine, and 29.4 months (95% CI 23.8-35.0) for Guanine/Guanine (P = 0.003).	Guanine	195-202	cyclin D1	Homo sapiens	30-39
25470788-6	2015	The survival in patients with Cyclin D1 G870A polymorphism Adenine/Adenine was 15.1 months (95% CI 11.3-18.9), 21.5 months (17.4-25.6) for Adenine/Guanine, and 29.4 months (95% CI 23.8-35.0) for Guanine/Guanine (P = 0.003).	Guanine	195-202	cyclin D1	Homo sapiens	30-39
25573651-5	2015	Western blot analysis indicated that GA mediated G1-phase cell cycle arrest by upregulation of cyclin-dependent kinase inhibitors (CKIs) (p18, p16, p27 and p21) and inhibition of cyclins (cyclin-D1, -D3 and -E) and cyclin-dependent kinases (CDKs) (CDK4, 6 and 2).	Glycyrrhetinic Acid	37-39	cyclin D1	Homo sapiens	188-209
25388553-0	2015	Effect of growth factors and steroid hormones on heme oxygenase and cyclin D1 expression in primary astroglial cell cultures.	Steroids	29-45	cyclin D1	Homo sapiens	68-77
25388553-2	2015	This study investigates the interaction between glucocorticoids or estrogens and GFs on the expression of heme oxygenase-1 (HO-1) and cyclin D1 in astrocyte cultures at 14 days treated for 48 or 60 hr with dexamethasone (DEX) or 48 hr with 17beta-estradiol (E2) alone or with GFs added only in the last 12 or 24 hr.	Dexamethasone	206-219	cyclin D1	Homo sapiens	134-143
25388553-5	2015	Sixty-hour DEX-alone pretreatment as well as the last-12-hr EGF treatment in 60-hr DEX-pretreated astrocyte cultures showed a significant increase of cyclin D1 expression.	Dexamethasone	11-14	cyclin D1	Homo sapiens	150-159
25388553-5	2015	Sixty-hour DEX-alone pretreatment as well as the last-12-hr EGF treatment in 60-hr DEX-pretreated astrocyte cultures showed a significant increase of cyclin D1 expression.	Dexamethasone	83-86	cyclin D1	Homo sapiens	150-159
25388553-6	2015	A significant decrease of cyclin D1 expression in the last-12-hr insulin-like growth factor-I (IGF-1)-treated cultures pretreated for 60 hr with DEX was observed.	Dexamethasone	145-148	cyclin D1	Homo sapiens	26-35
25617735-8	2015	Inhibition of cyclinD1 decreased the cell viability assessed by MTT and increased rate of apoptosis when exposed to 5-FU treatment while overexpression of cyclinD1 showed the reverse effect.	Fluorouracil	116-120	cyclin D1	Homo sapiens	14-22
25617735-11	2015	Inhibition of STAT3 decreased cyclinD1 expression to decrease the cell viability and increase rate of apoptosis when exposed to 5-FU treatment.	Fluorouracil	128-132	cyclin D1	Homo sapiens	30-38
25142862-6	2015	Moreover, phosphorylation of cyclin D1 at threonine 286 by GSK-3beta was required for PSAT1-induced blockage of cyclin D1 degradation.	Threonine	42-51	cyclin D1	Homo sapiens	29-38
25142862-6	2015	Moreover, phosphorylation of cyclin D1 at threonine 286 by GSK-3beta was required for PSAT1-induced blockage of cyclin D1 degradation.	Threonine	42-51	cyclin D1	Homo sapiens	112-121
25544362-10	2015	Treatment with sanguinarine, but not berberine, inhibited the proliferation of Rac1b cells, which was accompanied by significantly increased the level of PARP-89, and decreased both the level of cyclin-D1 and the percentage of BrdU positive cells.	sanguinarine	15-27	cyclin D1	Homo sapiens	195-204
25434456-9	2015	Further experiments showed that inhibition of cell proliferation by fluvastatin was associated with elevated IGFBP-6, p27, p53 levels and reduced survivin, cyclin B1, cyclin D1 and VEGF expression.	Fluvastatin	68-79	cyclin D1	Homo sapiens	167-176
25527205-5	2015	RESULTS: These results showed that oxymatrine inhibited the proliferation and invasion of gastric cells through inhibition of EGFR/Cyclin D1/CDK4/6, EGFR/Akt and MEK-1/ERK1/2/MMP2 pathway by inhibiting EGFR(p-Tyr845).	oxymatrine	35-45	cyclin D1	Homo sapiens	131-140
25305450-6	2015	Western blot showed that metformin activated caspase 3, caspase 9, PARP-1, Bak, and p21 and inactivated Mcl-1, HIAP-1, cyclin D1, CDK4, and CDK6.	Metformin	25-34	cyclin D1	Homo sapiens	119-128
26135564-6	2015	We found glucagon, which is substantially raised in patients with T2D, rapidly phosphorylates beta-catenin on serine 552 that is associated with increased expression of genes cyclin D1 (CCND1) and c-Myc (MYC), which are known to be involved in liver cancer.	Serine	110-116	cyclin D1	Homo sapiens	175-184
25603341-0	2015	Ophiobolin O isolated from Aspergillus ustus induces G1 arrest of MCF-7 cells through interaction with AKT/GSK3beta/cyclin D1 signaling.	ophiobolin O	0-12	cyclin D1	Homo sapiens	116-125
25603341-3	2015	In this study, we further verified ophiobolin O-induced G1 phase arrest in human breast cancer MCF-7 cells, and found that ophiobolin O reduced the phosphorylation level of AKT and GSK3beta, and induced down-regulation of cyclin D1.	ophiobolin O	123-135	cyclin D1	Homo sapiens	222-231
25603341-4	2015	The inverse docking (INVDOCK) analysis indicated that ophiobolin O could bind to GSK3beta, and GSK3beta knockdown abolished cyclin D1 degradation and G1 phase arrest.	ophiobolin O	54-66	cyclin D1	Homo sapiens	124-133
25603341-6	2015	These data suggest that ophiobolin O may induce G1 arrest in MCF-7 cells through interaction with AKT/GSK3beta/cyclin D1 signaling.	ophiobolin O	24-36	cyclin D1	Homo sapiens	111-120
25980816-7	2015	ROS generated by estrogens affect pro-proliferative (e.g. cyclin D1, Cdc2), prosurvival (e.g. AKT), antiapoptotic (e.g. BCl2) and pro-inflammatory (e.g. NF-kappaB) molecules.	Reactive Oxygen Species	0-3	cyclin D1	Homo sapiens	58-67
26135564-6	2015	We found glucagon, which is substantially raised in patients with T2D, rapidly phosphorylates beta-catenin on serine 552 that is associated with increased expression of genes cyclin D1 (CCND1) and c-Myc (MYC), which are known to be involved in liver cancer.	Serine	110-116	cyclin D1	Homo sapiens	186-191
25879038-7	2015	Specifically, we showed that curcumin is able to deregulate the expression of cyclin D1, PECAM-1, and p65, which are regulated by NF-kappaB.	Curcumin	29-37	cyclin D1	Homo sapiens	78-87
25743845-5	2015	RESULTS: H2O2 downregulated cyclin D1 and cyclin E to inhibit proliferation, and upregulated BAX to induce apoptosis in MCF-7 cells.	Hydrogen Peroxide	9-13	cyclin D1	Homo sapiens	28-37
25666914-2	2015	In this study, we found that beta-thujaplicin significantly suppressed the proliferation through arresting the cell cycle transition from G1 to S phase as well as inhibited the expression of cell cycle-related proteins, cyclin D1, and cyclin-dependent kinase 4 (CDK4) in MCF-7 and T47D luminal subtype breast cancer cells.	beta-thujaplicin	29-45	cyclin D1	Homo sapiens	220-229
26090392-6	2015	Furthermore, the expression levels of downstream genes (c-FOS, BCL-2, and CYCLIN D1) were increased by 17beta-estradiol and this effect was independently associated with activity of the EGFR-MAPK pathway.	Estradiol	103-119	cyclin D1	Homo sapiens	74-83
25869769-4	2015	At the molecular level, NVP-BEZ235 inhibited PI3K-AKT-mTORC1 activation and downregulated cyclin D1/cyclin B1 expressions, while increasing MEK/Erk phosphorylation in osteosarcoma cells.	dactolisib	28-34	cyclin D1	Homo sapiens	90-99
26229542-10	2015	Studies with JNK specific inhibitor, SP600125, showed that Huaier extract induced S phase arrest and decreased beta-catenin and cyclin D1 expression via JNK signaling pathway.	pyrazolanthrone	37-45	cyclin D1	Homo sapiens	128-137
25590413-9	2015	Western blot analysis demonstrated that Wnt-targeting genes, including c-Myc and cyclin D1, were upregulated and were relevant in inhibiting the expression of p21 in MES-SA/Dx5 cells.	2-(N-morpholino)ethanesulfonic acid	166-169	cyclin D1	Homo sapiens	81-90
25590413-10	2015	On the other hand, MES-SA cells expressed high levels of p21 and downregulated cyclin D1 and caused cell cycle arrest.	mes-sa	19-25	cyclin D1	Homo sapiens	79-88
25203678-9	2015	This suggests that VPA reduces intracellular ROS level by the modulation of KRIT1 and its correlated proteins, FoxO1, SOD2, and cyclin D1.	Reactive Oxygen Species	45-48	cyclin D1	Homo sapiens	128-137
25479723-0	2015	Silymarin induces cyclin D1 proteasomal degradation via its phosphorylation of threonine-286 in human colorectal cancer cells.	Silymarin	0-9	cyclin D1	Homo sapiens	18-27
25492214-4	2015	According to the flow cytometric analysis, curcumin treatment resulted in G2/M arrest in AGS cells, accompanied with an increased expression of cyclin B1 and a decreased expression of cyclin D1.	Curcumin	43-51	cyclin D1	Homo sapiens	184-193
26118026-3	2015	The authors investigated the association of Bcl1 polymorphism with predisposition to bronchial asthma, chronic obstructive pulmonary disease, with the nicotine addiction degree and with progressing disorders of pulmonary function in cystic fibrosis.	Nicotine	151-159	cyclin D1	Homo sapiens	44-48
25452171-6	2015	When data were stratified by postoperative treatments and CCND1 expression levels, the MST for patients treated with fluoropyrimidine plus platinum (n = 140) was significantly longer than for those treated with fluoropyrimidine only (n = 71) in both high and low CCND1 expression groups (65.0 vs. 29.0 months, P = 0.041; and 74.5 vs. 33.0 months, P = 0.003, respectively).	2-fluoropyrimidine	117-133	cyclin D1	Homo sapiens	58-63
25452171-6	2015	When data were stratified by postoperative treatments and CCND1 expression levels, the MST for patients treated with fluoropyrimidine plus platinum (n = 140) was significantly longer than for those treated with fluoropyrimidine only (n = 71) in both high and low CCND1 expression groups (65.0 vs. 29.0 months, P = 0.041; and 74.5 vs. 33.0 months, P = 0.003, respectively).	2-fluoropyrimidine	117-133	cyclin D1	Homo sapiens	263-268
25452171-6	2015	When data were stratified by postoperative treatments and CCND1 expression levels, the MST for patients treated with fluoropyrimidine plus platinum (n = 140) was significantly longer than for those treated with fluoropyrimidine only (n = 71) in both high and low CCND1 expression groups (65.0 vs. 29.0 months, P = 0.041; and 74.5 vs. 33.0 months, P = 0.003, respectively).	Platinum	139-147	cyclin D1	Homo sapiens	58-63
25452171-6	2015	When data were stratified by postoperative treatments and CCND1 expression levels, the MST for patients treated with fluoropyrimidine plus platinum (n = 140) was significantly longer than for those treated with fluoropyrimidine only (n = 71) in both high and low CCND1 expression groups (65.0 vs. 29.0 months, P = 0.041; and 74.5 vs. 33.0 months, P = 0.003, respectively).	Platinum	139-147	cyclin D1	Homo sapiens	263-268
25791399-5	2015	RESULTS: CCND1, c-Fos and c-Jun mRNA levels were all significantly increased by treatment with progesterone in QGP-1 cells with PRB expression compared with PRA-transfected cells (p = 0.02, p = 0.007 and p = 0.001, respectively).	Progesterone	95-107	cyclin D1	Homo sapiens	9-14
25791399-8	2015	CONCLUSION: The results of the present study demonstrate that PRA could play an inhibitory role in the cell proliferation of PNETs, possibly by inhibiting PRB-mediated signals in the presence of progesterone, which could result in decreased CCND1 expression.	Progesterone	195-207	cyclin D1	Homo sapiens	241-246
25436006-3	2015	The present study examined whether the CCND1 c.723G&gt;A (rs9344; p.Pro241=) and c.669C&gt;T (rs3862792; p.Phe223=) variants have an impact on DTC susceptibility.	dtc	143-146	cyclin D1	Homo sapiens	39-44
25531367-6	2014	Concurrently, maduramicin downregulated protein expression of cyclin D1, cyclin-dependent kinases (CDK4 and CDK6), and CDC25A, and upregulated expression of the CDK inhibitors (p21Cip1 and p27Kip1), resulting in decreased phosphorylation of Rb.	maduramicin	14-25	cyclin D1	Homo sapiens	62-71
25496649-19	2014	Cyclin D1 was induced to 290% (HCC1806) and 170% (HCC70) and completely inhibited by estriol.	Estriol	85-92	cyclin D1	Homo sapiens	0-9
25674209-5	2014	On the molecular level, we observed that exposure to formononetin altered the expression levels of cell cycle arrest-associated proteins p21, cyclin A and cyclin D1.	formononetin	53-65	cyclin D1	Homo sapiens	155-164
25443739-5	2014	RESULTS: An upregulation of cell cycle regulators: cyclin D1/cdk4 and cyclin E/cdk2 and anti-apoptotic Bcl-2, along with the suppression of DNA repair enzymes: MLH1 and MSH2; tumour suppressors: p53, p21and Rb and pro-apoptotic proteins: Bax and Bad were observed in the DSS, DMH and DSS+DMH groups.	1,2-Dimethylhydrazine	288-291	cyclin D1	Homo sapiens	51-60
25450696-4	2014	Furthermore, our results indicated that curcumin inhibited OSCC cells (SCC-9 cells) proliferation through up-regulating miR-9 expression, and suppressing Wnt/beta-catenin signaling by increasing the expression levels of the GSK-3beta, phosphorylated GSK-3beta and beta-catenin, and decreasing the cyclin D1 level.	Curcumin	40-48	cyclin D1	Homo sapiens	297-306
25368960-1	2014	Biphenyl-4-carboxylic acid-[2-(1H-indol-3-yl)-ethyl]-methylamide 1 (CA224) is a nonplanar analogue of fascaplysin (2) that specifically inhibits Cdk4-cyclin D1 in vitro.	biphenyl-4-carboxylic acid-[2-(1h-indol-3-yl)-ethyl]-methylamide	0-64	cyclin D1	Homo sapiens	150-159
25368960-1	2014	Biphenyl-4-carboxylic acid-[2-(1H-indol-3-yl)-ethyl]-methylamide 1 (CA224) is a nonplanar analogue of fascaplysin (2) that specifically inhibits Cdk4-cyclin D1 in vitro.	CA 224	68-73	cyclin D1	Homo sapiens	150-159
25745771-8	2014	These results suggest that the ability of IP6 to inhibit colon cancer cells proliferation may be mediated through downregulation of genes encoding cyclin D1 and histone H3 at the mRNA level.	Phytic Acid	42-45	cyclin D1	Homo sapiens	147-156
25352148-7	2014	EGCG repressed the expression of cyclin D1 and c-myc, which are beta-catenin/T-cell factor-dependent genes, and inhibited the proliferation of colon cancer cells.	epigallocatechin gallate	0-4	cyclin D1	Homo sapiens	33-42
25244411-5	2014	In addition, there was a reduction in both the mRNA and protein expression of cyclin D1, while p21 protein expression was increased; the reduction in cyclin D1 expression was blocked by the proteasome inhibitor, MG132, or c-Jun N-terminal kinase (JNK) inhibitor; both beta-catenin and JNK were phosphorylated by activated PKG.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	212-217	cyclin D1	Homo sapiens	78-87
25244411-5	2014	In addition, there was a reduction in both the mRNA and protein expression of cyclin D1, while p21 protein expression was increased; the reduction in cyclin D1 expression was blocked by the proteasome inhibitor, MG132, or c-Jun N-terminal kinase (JNK) inhibitor; both beta-catenin and JNK were phosphorylated by activated PKG.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	212-217	cyclin D1	Homo sapiens	150-159
25263998-9	2014	Similarly an overexpression of CyclinD1 and elevation of ki-67 was found in the spitzoid component confirming a raise in proliferation.	spitzoid	80-88	cyclin D1	Homo sapiens	31-39
25065586-10	2014	In the in vitro model, androstenediol exerted increase in cyclin D1 (p&lt;0.05) and a decrease in p27 protein level (p&lt;0.05), while Ki67 in St-T1b cells increased under this stimulus (p&lt;0.05).	Androstenediol	23-37	cyclin D1	Homo sapiens	58-67
25344679-9	2014	Western blot analysis showed that FTY720 induced cleavage of caspases 3, 8 and 9, and of PARP, in a dose-dependent manner, consistent with a substantial decrease in p-STAT3, Bcl-xL, Bcl-2, survivin, cyclin D1, cyclin E, N-cadherin, vimentin, VEGF and TWIST1.	Fingolimod Hydrochloride	34-40	cyclin D1	Homo sapiens	199-208
25260414-5	2014	When p-ERK was inhibited using U0126 (inhibitor of p-ERK), cell viability decreased and the expression of p-c-Jun and cyclinD1 was reduced accordingly, suggesting that p-ERK functions upstream of p-c-Jun and cyclinD1.	U 0126	31-36	cyclin D1	Homo sapiens	118-126
25260414-5	2014	When p-ERK was inhibited using U0126 (inhibitor of p-ERK), cell viability decreased and the expression of p-c-Jun and cyclinD1 was reduced accordingly, suggesting that p-ERK functions upstream of p-c-Jun and cyclinD1.	U 0126	31-36	cyclin D1	Homo sapiens	208-216
26370682-9	2015	In addition, the present study raised the possibility that Clock and Bmal1 may in part play a role in preventing the cells from entering G1 to S phase of cell cycle via suppression of CyclinD1 expression, and thus acquiring resistance to Paclitaxel.	Paclitaxel	238-248	cyclin D1	Homo sapiens	184-192
25479723-7	2015	Inhibition of proteasomal degradation by MG132 attenuated silymarin-mediated cyclin D1 downregulation and the half-life of cyclin D1 was decreased in the cells treated with silymarin.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	41-46	cyclin D1	Homo sapiens	77-86
25479723-7	2015	Inhibition of proteasomal degradation by MG132 attenuated silymarin-mediated cyclin D1 downregulation and the half-life of cyclin D1 was decreased in the cells treated with silymarin.	Silymarin	58-67	cyclin D1	Homo sapiens	77-86
25479723-7	2015	Inhibition of proteasomal degradation by MG132 attenuated silymarin-mediated cyclin D1 downregulation and the half-life of cyclin D1 was decreased in the cells treated with silymarin.	Silymarin	173-182	cyclin D1	Homo sapiens	77-86
25479723-7	2015	Inhibition of proteasomal degradation by MG132 attenuated silymarin-mediated cyclin D1 downregulation and the half-life of cyclin D1 was decreased in the cells treated with silymarin.	Silymarin	173-182	cyclin D1	Homo sapiens	123-132
25479723-8	2015	In addition, silymarin increased phosphorylation of cyclin D1 at threonine-286 and a point mutation of threonine-286 to alanine attenuated silymarin-mediated cyclin D1 downregulation.	Silymarin	13-22	cyclin D1	Homo sapiens	52-61
25479723-8	2015	In addition, silymarin increased phosphorylation of cyclin D1 at threonine-286 and a point mutation of threonine-286 to alanine attenuated silymarin-mediated cyclin D1 downregulation.	Threonine	65-74	cyclin D1	Homo sapiens	52-61
25479723-8	2015	In addition, silymarin increased phosphorylation of cyclin D1 at threonine-286 and a point mutation of threonine-286 to alanine attenuated silymarin-mediated cyclin D1 downregulation.	Silymarin	139-148	cyclin D1	Homo sapiens	158-167
25479723-9	2015	Inhibition of NF-kappaB by a selective inhibitor, BAY 11-7082 suppressed cyclin D1 phosphorylation and downregulation by silymarin.	3-(4-methylphenylsulfonyl)-2-propenenitrile	50-61	cyclin D1	Homo sapiens	73-82
25479723-10	2015	From these results, we suggest that silymarin-mediated cyclin D1 downregulation may result from proteasomal degradation through its threonine-286 phosphorylation via NF-kappaB activation.	Silymarin	36-45	cyclin D1	Homo sapiens	55-64
25479723-10	2015	From these results, we suggest that silymarin-mediated cyclin D1 downregulation may result from proteasomal degradation through its threonine-286 phosphorylation via NF-kappaB activation.	Threonine	132-141	cyclin D1	Homo sapiens	55-64
25479723-11	2015	The current study provides new mechanistic link between silymarin, cyclin D1 downregulation and cell growth in human colorectal cancer cells.	Silymarin	56-65	cyclin D1	Homo sapiens	67-76
25379883-8	2015	OHF treatment significantly reduced tumor volume and this decrease was correlated with decreased Cdk4 and cyclin D1 expression.	ohf	0-3	cyclin D1	Homo sapiens	106-115
25557483-6	2015	After cycloheximide treatment, cyclin D1 in the persistently infected cells lasted several hours longer than those in acutely infected cells.	Cycloheximide	6-19	cyclin D1	Homo sapiens	31-40
25557483-8	2015	Inhibition of the GSK-3ss by lithium chloride treatment rescued a significant number of cells from cytolysis in JEV acute infection, which coincided with the levels of cyclin D1 that escaped from proteolysis.	Lithium Chloride	29-45	cyclin D1	Homo sapiens	168-177
25868784-5	2015	Silibinin with 0.5 or 5 microM arsenic induced G1 or G2/M phase arrest, respectively, and decreased the protein levels of CDK2, -4, and -6 and cyclin D1, D3, and E and increased CDK inhibitors p21 and p27.	Silybin	0-9	cyclin D1	Homo sapiens	143-152
25868784-5	2015	Silibinin with 0.5 or 5 microM arsenic induced G1 or G2/M phase arrest, respectively, and decreased the protein levels of CDK2, -4, and -6 and cyclin D1, D3, and E and increased CDK inhibitors p21 and p27.	Arsenic	31-38	cyclin D1	Homo sapiens	143-152
25244400-10	2015	We also show that cyclic adenosine monophosphate response element-binding protein (CREB)-cyclin D1 signaling mediates, at least partially, the role of TMPRSS4 in thyroid cancer cell proliferation.	Cyclic AMP	18-48	cyclin D1	Homo sapiens	89-98
25486524-10	2014	Similarly, inhibition of ATM with KU55933 abrogated nuclear cyclin D1 accumulation by induction of apoptosis in ATM-complemented cells exposed to low-dose FR.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	34-41	cyclin D1	Homo sapiens	60-69
25218350-5	2014	HIF-2alpha played a dominant role in regulating VEGF, thus sorafenib in turn increased the expression of VEGF (a downstream molecule of both HIF-1 and HIF-2) and cyclin D1 (a downstream molecule of HIF-2), but reduced the expression of LDHA (a downstream molecule of HIF-1), in hypoxic HCC cells.	Sorafenib	59-68	cyclin D1	Homo sapiens	162-171
25280563-5	2014	Furthermore, we demonstrated that miR-105 could deactivated the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway by downregulating insulin receptor substrate-1, 3-phosphoinositide-dependent protein kinase-1 and AKT1 directly, resulting in increasing cyclin-dependent kinase inhibitors 1A and 1B (p21(Cip1) and p27(Kip1)) and decreasing cyclin D1 expression in HCC.	mir-105	34-41	cyclin D1	Homo sapiens	342-351
25674233-5	2014	Here, we demonstrate that DHA inhibited cell proliferation in the A549 lung cancer cell line through suppression of the AKT/Gsk-3beta/cyclin D1 signaling pathway.	artenimol	26-29	cyclin D1	Homo sapiens	134-143
25674233-7	2014	Flow cytometry analysis demonstrated that DHA treatment of A549 cells resulted in cell cycle arrest at the G1 phase, which correlated with apparent downregulation of both mRNA and protein levels of both PCNA and cyclin D1.	artenimol	42-45	cyclin D1	Homo sapiens	212-221
25443739-5	2014	RESULTS: An upregulation of cell cycle regulators: cyclin D1/cdk4 and cyclin E/cdk2 and anti-apoptotic Bcl-2, along with the suppression of DNA repair enzymes: MLH1 and MSH2; tumour suppressors: p53, p21and Rb and pro-apoptotic proteins: Bax and Bad were observed in the DSS, DMH and DSS+DMH groups.	Dextran Sulfate	271-274	cyclin D1	Homo sapiens	51-60
25443739-5	2014	RESULTS: An upregulation of cell cycle regulators: cyclin D1/cdk4 and cyclin E/cdk2 and anti-apoptotic Bcl-2, along with the suppression of DNA repair enzymes: MLH1 and MSH2; tumour suppressors: p53, p21and Rb and pro-apoptotic proteins: Bax and Bad were observed in the DSS, DMH and DSS+DMH groups.	1,2-Dimethylhydrazine	276-279	cyclin D1	Homo sapiens	51-60
25443739-5	2014	RESULTS: An upregulation of cell cycle regulators: cyclin D1/cdk4 and cyclin E/cdk2 and anti-apoptotic Bcl-2, along with the suppression of DNA repair enzymes: MLH1 and MSH2; tumour suppressors: p53, p21and Rb and pro-apoptotic proteins: Bax and Bad were observed in the DSS, DMH and DSS+DMH groups.	Dextran Sulfate	284-287	cyclin D1	Homo sapiens	51-60
25437003-8	2014	These findings demonstrate that TRUE gene silencing of cyclin D1 leads to inhibition of the growth of HNSCC cells and suggest that these sgRNAs alone or combined with cisplatin may be a useful new therapy for HNSCCs.	Cisplatin	167-176	cyclin D1	Homo sapiens	55-64
25231004-8	2014	PDGF-BB-dependent PASMC proliferation was regulated via the paxillin-Erk1/2-cyclin D1 pathway.	pasmc	18-23	cyclin D1	Homo sapiens	76-85
25469035-10	2014	Our results showed that treatment with 17beta-estradiol and/or ER agonists in human LoVo colorectal cancer cells activated p53 and then up-regulated p21 and p27 protein levels, subsequently inhibiting the downstream target gene, cyclin D1, which regulates cell proliferation.	Estradiol	39-55	cyclin D1	Homo sapiens	229-238
25393427-6	2014	There was also a moderate cell cycle arrest at G1/S checkpoint in the ethanol treated cells, which is associated with a reduced level of cyclin D1 in these cells.	Ethanol	70-77	cyclin D1	Homo sapiens	137-146
25386960-4	2014	Moreover, p,p"-DDE exposure could activate Wnt/beta-catenin and Hedgehog/Gli1 signaling cascades, and the expression level of c-Myc and cyclin D1 was significantly increased.	Dichlorodiphenyl Dichloroethylene	10-18	cyclin D1	Homo sapiens	136-145
25386960-5	2014	Consistently, p,p"-DDE-induced cell proliferation along with upregulated c-Myc and cyclin D1 were impeded by beta-catenin siRNA or Gli1 siRNA.	Dichlorodiphenyl Dichloroethylene	14-22	cyclin D1	Homo sapiens	83-92
25745771-1	2014	The aim of the present study was to examine the influence of IP6, a naturally occurring phytochem- ical, on the expression of genes coding for proliferation markers, i.e., cyclin D1 (CCND1) and histone H3 in IL-1beta-stimulated intestinal cancer cell line Caco-2.	Phytic Acid	61-64	cyclin D1	Homo sapiens	172-181
25745771-1	2014	The aim of the present study was to examine the influence of IP6, a naturally occurring phytochem- ical, on the expression of genes coding for proliferation markers, i.e., cyclin D1 (CCND1) and histone H3 in IL-1beta-stimulated intestinal cancer cell line Caco-2.	Phytic Acid	61-64	cyclin D1	Homo sapiens	183-188
25745771-5	2014	IP6 had no influence on IL-1beta-stimulated CCND1 expression for 3 and 6 h. After 12 h, statistically significant decrease in CCND1 mRNA was observed in cells exposed to IL-1beta and IP6 (1 and 2.5 mM) in relation to cells treated with IL-1beta only.	Phytic Acid	0-3	cyclin D1	Homo sapiens	126-131
25745771-5	2014	IP6 had no influence on IL-1beta-stimulated CCND1 expression for 3 and 6 h. After 12 h, statistically significant decrease in CCND1 mRNA was observed in cells exposed to IL-1beta and IP6 (1 and 2.5 mM) in relation to cells treated with IL-1beta only.	Phytic Acid	183-186	cyclin D1	Homo sapiens	126-131
25279148-9	2014	SU11274 (30 muM) decreased the expression levels of cyclin D1 in HLF and PLC/PRL/5 cells to 45.1+-11.6 and 30.1+-10.3%, respectively.	((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)	0-7	cyclin D1	Homo sapiens	52-61
25289059-6	2014	Even low concentrations of GA (0.02 mumol/l) were found to inhibit the Bcl-2 and cyclin D1 protein expression induced by VEGF-C.	geldanamycin	27-29	cyclin D1	Homo sapiens	81-90
25073953-5	2014	Moreover, real-time PCR analysis of CyclinD1, Hes1 and MUC2 was done in HT29 cells upon N-[N-(3, 5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT) treatment.	n-[n-(3, 5-difluorophenacetyl)-l-alanyl]-s-phenylglycine t-butyl ester	88-158	cyclin D1	Homo sapiens	36-44
25073953-5	2014	Moreover, real-time PCR analysis of CyclinD1, Hes1 and MUC2 was done in HT29 cells upon N-[N-(3, 5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT) treatment.	dapt	160-164	cyclin D1	Homo sapiens	36-44
25073953-8	2014	CyclinD1 transcript levels decreased 1.2- and 1.6-fold, and MUC2 transcript level increased 4.3- and 7.5-fold in 12.5 and 25 microM DAPT-treated HT29 cells.	dapt	132-136	cyclin D1	Homo sapiens	0-8
25174327-8	2014	Erk1/2 inhibition with either U0126 treatment or specific siRNA silencing resulted in decreases in p-ser STAT3 and cyclin D1 levels and increases in p-tyr STAT3 in OSCC cells.	U 0126	30-35	cyclin D1	Homo sapiens	115-124
25296971-4	2014	Treatment with ganetespib (50 nM) for 24 hours inhibited cyclin D1 and pRb at the transcriptional and translational levels and induced p21, leading to G0/G1 cell cycle arrest in both CRC cell lines (HCT-116 and HT-29).	STA 9090	15-25	cyclin D1	Homo sapiens	57-66
25479723-0	2015	Silymarin induces cyclin D1 proteasomal degradation via its phosphorylation of threonine-286 in human colorectal cancer cells.	Threonine	79-88	cyclin D1	Homo sapiens	18-27
25479723-2	2015	For anti-cancer activity, silymarin is known to regulate cell cycle progression through cyclin D1 downregulation.	Silymarin	26-35	cyclin D1	Homo sapiens	88-97
25479723-3	2015	However, the mechanism of silymarin-mediated cyclin D1 downregulation still remains unanswered.	Silymarin	26-35	cyclin D1	Homo sapiens	45-54
25479723-4	2015	The current study was performed to elucidate the molecular mechanism of cyclin D1 downregulation by silymarin in human colorectal cancer cells.	Silymarin	100-109	cyclin D1	Homo sapiens	72-81
25479723-5	2015	The treatment of silymarin suppressed the cell proliferation in HCT116 and SW480 cells and decreased cellular accumulation of exogenously-induced cyclin D1 protein.	Silymarin	17-26	cyclin D1	Homo sapiens	146-155
25419360-6	2014	As a result, protein abundance of Bcl-2 and cyclin D1 was decreased and PTEN was increased in cells exposed to metformin.	Metformin	111-120	cyclin D1	Homo sapiens	44-53
25107568-16	2014	Elevated levels of P21 and GADD45, in concert with cyclin D1, also mediated the antiproliferative response of HL-60 in the presence of 1,25-(OH)2D3 and PS121912.	Calcitriol	135-147	cyclin D1	Homo sapiens	51-60
25258011-0	2014	The influence of arsenic trioxide on the cell cycle, apoptosis and expression of cyclin D1 in the Jurkat cell line.	Arsenic Trioxide	17-33	cyclin D1	Homo sapiens	81-90
25258011-3	2014	In this study we aimed to evaluate the expression and localization of cyclin D1 in arsenic trioxide (ATO) treated Jurkat cells (lymphoblastic leukemia cell line) and to correlate these results with the extent of cell death and/or cell cycle alterations.	Arsenic Trioxide	83-99	cyclin D1	Homo sapiens	70-79
25258011-3	2014	In this study we aimed to evaluate the expression and localization of cyclin D1 in arsenic trioxide (ATO) treated Jurkat cells (lymphoblastic leukemia cell line) and to correlate these results with the extent of cell death and/or cell cycle alterations.	Arsenic Trioxide	101-104	cyclin D1	Homo sapiens	70-79
25258011-9	2014	On the other hand, we found a nuclear-cytoplasmic shift of this protein as a major treatment-related response, which was in good accord with an increased rate of cell death and suggested that cyclin D1 cytoplasmic degradation is an important determinant of the therapeutic efficiency of ATO in the Jurkat cell line.	Arsenic Trioxide	287-290	cyclin D1	Homo sapiens	192-201
25046358-7	2014	Moreover, D261 induced cell cycle arrest with a reduced expression of various G 1/S transition-related molecules including cyclin D1, cyclin E1, CDK4, and CDK2, but without influencing apoptosis in NSCLC cells.	d261	10-14	cyclin D1	Homo sapiens	123-132
25249644-0	2014	The proliferative gene cyclin D1 and gluconeogenesis--could suppressing glucose production also promote cancer?	Glucose	72-79	cyclin D1	Homo sapiens	23-32
25062958-7	2014	Exposure to spermine NONOate, 8-bromo-cGMP, or sildenafil (a phosphodiesterase type 5 inhibitor) also increased the expression of beta-catenin-dependent transcripts, IL-8, and cyclin D1.	Sildenafil Citrate	47-57	cyclin D1	Homo sapiens	176-185
24928376-8	2014	The Bcl-2 and Cyclin D1, targets of Hh signaling, also decreased after treatment with quercetin, respectively.	Quercetin	86-95	cyclin D1	Homo sapiens	14-23
25200445-2	2014	To understand this phenomenon, we investigated the association between NAC resistance and CCND1, which is frequently overexpressed in ER-positive tumors.	nac	71-74	cyclin D1	Homo sapiens	90-95
25143352-5	2014	It represses the levels of C-terminal beta-CATENIN phosphoforms and of CYCLIN D1 in an okadaic acid-sensitive manner, indicating its action involves protein phosphatases.	Okadaic Acid	87-99	cyclin D1	Homo sapiens	71-80
25062958-7	2014	Exposure to spermine NONOate, 8-bromo-cGMP, or sildenafil (a phosphodiesterase type 5 inhibitor) also increased the expression of beta-catenin-dependent transcripts, IL-8, and cyclin D1.	spermine nitric oxide complex	12-28	cyclin D1	Homo sapiens	176-185
25062958-7	2014	Exposure to spermine NONOate, 8-bromo-cGMP, or sildenafil (a phosphodiesterase type 5 inhibitor) also increased the expression of beta-catenin-dependent transcripts, IL-8, and cyclin D1.	8-bromocyclic GMP	30-42	cyclin D1	Homo sapiens	176-185
25308364-11	2014	WNT5A promoted Cyclin D1 expression through phosphorylation of AKT which consequently enhanced G1-S transition and gemcitabine resistance.	gemcitabine	115-126	cyclin D1	Homo sapiens	15-24
23436777-6	2014	Fludioxonil and fenhexamid were ERalpha agonists (EC50 -values of 3.7 and 9.0 muM, respectively) and had time-dependent effects on endogenous ERalpha-target gene expression (cyclin D1, progesterone receptor, and nuclear respiratory factor 1) in MCF-7 human breast cancer cells.	fludioxonil	0-11	cyclin D1	Homo sapiens	174-183
23436777-6	2014	Fludioxonil and fenhexamid were ERalpha agonists (EC50 -values of 3.7 and 9.0 muM, respectively) and had time-dependent effects on endogenous ERalpha-target gene expression (cyclin D1, progesterone receptor, and nuclear respiratory factor 1) in MCF-7 human breast cancer cells.	N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide	16-26	cyclin D1	Homo sapiens	174-183
25198581-5	2014	The protein expressions of cyclin D1 increased with NAAG treatment and decreased after siRNA treatment.	isospaglumic acid	52-56	cyclin D1	Homo sapiens	27-36
24905570-6	2014	Moreover, salinomycin was able to suppress the expression of cyclin D1 and survivin, two targets of both Wnt/beta-catenin and mTORC1 signaling, in prostate and breast cancer cells, and displayed remarkable anticancer activity.	salinomycin	10-21	cyclin D1	Homo sapiens	61-70
25536607-11	2014	CyclinD1 and CDC25A were downregulated by P-EGCG by 2.49 and 2.63-fold, respectively.	p-egcg	42-48	cyclin D1	Homo sapiens	0-8
25536607-14	2014	P-EGCG mediated apoptosis might be associated with upregulation of TGF-beta2 gene and downregulation of cyclinD1 and CDC25A genes.	epigallocatechin gallate	2-6	cyclin D1	Homo sapiens	104-112
25050564-2	2014	Annexin V/propidium iodide staining, MTT assay and western blot analysis revealed that resveratrol induced cycle arrest in the two cell lines, which was evidenced by cell cycle analysis and changes in the expression of the cell cycle proteins cyclin-dependent kinase (CDK) 2, CDK4, cyclin D1, proliferating cell nuclear antigen and P21.	Resveratrol	87-98	cyclin D1	Homo sapiens	282-291
25302079-11	2014	Furthermore, pioglitazone treatment or PPARgamma overexpression increased caspase 3 and caspase 9 expression, and decreased the expression of cyclin B1 and cyclin D1 in VSMCs.	Pioglitazone	13-25	cyclin D1	Homo sapiens	156-165
25144895-3	2014	The epoxides, but not their urea, amide, or carbamate isosteres, impaired ATP production, enhanced caspase-3 activity, and activated c-jun-N-terminal-kinase signaling, leading to cyclin D1 down-regulation and cell cycle arrest in G1-phase.	Epoxy Compounds	4-12	cyclin D1	Homo sapiens	179-188
24819721-5	2014	In this study, cell cycle-specific cyclin D1 was found to be a potential target of miR-365 by direct binding.	mir-365	83-90	cyclin D1	Homo sapiens	35-44
25122067-0	2014	The CDK4/6 inhibitor LY2835219 overcomes vemurafenib resistance resulting from MAPK reactivation and cyclin D1 upregulation.	abemaciclib	21-30	cyclin D1	Homo sapiens	101-110
25122067-0	2014	The CDK4/6 inhibitor LY2835219 overcomes vemurafenib resistance resulting from MAPK reactivation and cyclin D1 upregulation.	Vemurafenib	41-52	cyclin D1	Homo sapiens	101-110
25122067-4	2014	Here, we describe that cell lines with acquired resistance to vemurafenib show reactivation of MAPK signaling and upregulation of cyclin D1 and are sensitive to inhibition of LY2835219, a selective inhibitor of cyclin-dependent kinase (CDK) 4/6.	Vemurafenib	62-73	cyclin D1	Homo sapiens	130-139
25122067-7	2014	Consistently, we found that MAPK is reactivated and cyclin D1 is elevated in vemurafenib-resistant tumors, as well as in the resistant cell lines derived from these tumors.	Vemurafenib	77-88	cyclin D1	Homo sapiens	52-61
25122067-10	2014	Similarly, RNAi-mediated knockdown of cyclin D1 induced significantly higher rate of apoptosis in the resistant cells than in parental cells, suggesting that elevated cyclin D1 activity is important for the survival of vemurafenib-resistant cells.	Vemurafenib	219-230	cyclin D1	Homo sapiens	38-47
25122067-10	2014	Similarly, RNAi-mediated knockdown of cyclin D1 induced significantly higher rate of apoptosis in the resistant cells than in parental cells, suggesting that elevated cyclin D1 activity is important for the survival of vemurafenib-resistant cells.	Vemurafenib	219-230	cyclin D1	Homo sapiens	167-176
25122067-11	2014	Altogether, we propose that targeting cyclin D1-CDK4/6 signaling by LY2835219 is an effective strategy to overcome MAPK-mediated resistance to B-RAF inhibitors in B-RAF V600E melanoma.	abemaciclib	68-77	cyclin D1	Homo sapiens	38-47
25109327-11	2014	Moreover, after inhibition of Rac1 or GSK3 following proteasome inhibitor MG132 treatment, cyclin D1 expression at the protein level remained constant, indicating that Rac1 and GSK3 may regulate cyclin D1 turnover through phosphorylation and degradation.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	74-79	cyclin D1	Homo sapiens	195-204
24597985-4	2014	Compared with the use of DEX or low-dose anisomycin alone, co-treatment with them resulted in a significant increase of growth inhibition, apoptosis and cell cycle arrest in CEM-C1 cells through induction of activated caspase-3 and up-regulation of Bim, p21and p27, and down-regulation of Mcl-1, Bcl-2, c-myc, cyclin A and cyclin D1.	Dexamethasone	25-28	cyclin D1	Homo sapiens	323-332
24798520-8	2014	lincRNA-p21 and ncRNA-CCND1 were the main molecules; exosome levels of them best reflect the change of their cellular levels upon exposure of the cells to bleomycin-induced DNA damage.	Bleomycin	155-164	cyclin D1	Homo sapiens	22-27
24597985-4	2014	Compared with the use of DEX or low-dose anisomycin alone, co-treatment with them resulted in a significant increase of growth inhibition, apoptosis and cell cycle arrest in CEM-C1 cells through induction of activated caspase-3 and up-regulation of Bim, p21and p27, and down-regulation of Mcl-1, Bcl-2, c-myc, cyclin A and cyclin D1.	Anisomycin	41-51	cyclin D1	Homo sapiens	323-332
25017118-8	2014	Pretreatment with the ERK1/2-specific inhibitor U0126 and pertussis toxin prevented the suppression of cyclin D1 expression, however did not affect DNA ladder formation.	U 0126	48-53	cyclin D1	Homo sapiens	103-112
24932741-8	2014	Furthermore, the expression of NF-kappaB downstream target genes including c-FLIP, cyclinD1, c-myc, and c-IAP2 showed the same variation trend as NF-kappaB activity both at mRNA and protein levels, which were induced by lower doses of MC-RR and suppressed by higher doses.	microcystin RR	235-240	cyclin D1	Homo sapiens	83-91
25165862-5	2014	Western blot analysis of Sch B-treated cells revealed the upregulation of Bax, cleaved caspase-9, cleaved caspase-3, cleaved PARP and downregulation of Bcl-2, NF-kappaB, cyclin D1 and CDK-4.	schizandrin B	25-30	cyclin D1	Homo sapiens	170-179
24867094-5	2014	Crebanine also potentiated TNF-alpha-induced apoptosis which correlated with the suppression of the gene products linked to cell survival, B cell lymphoma-extra large, and proliferation, cyclin D1.	crebanine	0-9	cyclin D1	Homo sapiens	187-196
25337187-6	2014	FoxM1 inhibition by thiostrepton or siRNA inhibited proliferation of NPC cells by down-regulation of cyclin D1 and cyclin E1.	Thiostrepton	20-32	cyclin D1	Homo sapiens	101-110
24968063-4	2014	Our results indicated that the proliferation of human colorectal adenocarcinoma DLD1 cells was significantly promoted after exposed to low concentrations of p,p"-DDT ranging from 10(-12) to 10(-7) M for 96 h. Exposure to p,p"-DDT from 10(-10) to 10(-8) M led to upregulation of phospho-GSK3beta (Ser9), beta-catenin, c-Myc and cyclin D1 in DLD1 cells.	DDT	157-165	cyclin D1	Homo sapiens	327-336
24968063-4	2014	Our results indicated that the proliferation of human colorectal adenocarcinoma DLD1 cells was significantly promoted after exposed to low concentrations of p,p"-DDT ranging from 10(-12) to 10(-7) M for 96 h. Exposure to p,p"-DDT from 10(-10) to 10(-8) M led to upregulation of phospho-GSK3beta (Ser9), beta-catenin, c-Myc and cyclin D1 in DLD1 cells.	DDT	221-229	cyclin D1	Homo sapiens	327-336
24726840-9	2014	In vitro assays prove that Ser-727 phosphorylation of Stat3 affects the transcriptional activity of its downstream targets like SOCS3, bcl-xl and Cyclin D1.	Serine	27-30	cyclin D1	Homo sapiens	146-155
24295217-8	2014	alpha-Mangostin inhibited the expression levels of matrix metallopeptidase 9 (MMP9), cyclin D1, and gp130; however, increased expression of tissue inhibitor of metalloproteinase 1 (TIMP1) was observed in PC cells.	mangostin	0-15	cyclin D1	Homo sapiens	85-94
24875448-5	2014	Western blotting analysis revealed that suppression of BLBC growth by sanguinarine was correlated with a concurrent upregulation of p27 and downregulation of cyclin D1 and with the inhibition of STAT3 activation.	sanguinarine	70-82	cyclin D1	Homo sapiens	158-167
24797937-5	2014	In addition, calycosin effectively down-regulated cellular mRNA expressions of IkappaBalpha, NF-kappaB p65 and cyclin D1 through RT-PCR assay (P&lt;0.01).	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	cyclin D1	Homo sapiens	111-120
24744211-3	2014	We found significantly higher BLL and BCL levels in people living within 2 km of an abandoned metal mine (n = 3,165, BCL = 1.87 mug/L, BLL = 2.91 mug/dL) compared to people living more than 2 km away (n = 2,517, BCL = 1.31 mug/L, BLL = 2.82 mug/dL; P &lt; 0.0001) and to the general population values reported in the literature.	Metals	94-99	cyclin D1	Homo sapiens	117-124
24682388-5	2014	In addition, ALO induced cell cycle arrest at the G2/M phase with a concomitant increase in p21 and p53 and a decrease in cyclin D1 and B1.	aloperine	13-16	cyclin D1	Homo sapiens	122-131
24858230-7	2014	DBP, a type of phthalate, was shown to promote LNCaP cell proliferation by upregulating the gene expression of c-myc and cyclin D1 and by downregulating the expression of p21.	phthalic acid	15-24	cyclin D1	Homo sapiens	121-130
24712725-8	2014	Inhibition of proteosomal degradation using MG-132 and Ada-(Ahx)3-(Leu)3-vinyl sulfone ameliorates PCA-induced downregulation of beta-catenin and cyclin D1.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	44-50	cyclin D1	Homo sapiens	146-155
24712725-8	2014	Inhibition of proteosomal degradation using MG-132 and Ada-(Ahx)3-(Leu)3-vinyl sulfone ameliorates PCA-induced downregulation of beta-catenin and cyclin D1.	Ada-(Ahx)3-(Leu)3-Vinyl Sulfone	55-86	cyclin D1	Homo sapiens	146-155
24889088-6	2014	Furthermore, flow cytometric cell cycle analysis revealed that germacrone induced G1 phase arrest, associated with an obvious decrease in the expression of cyclin D1 and CDK2 and an increased expression of p21.	germacrone	63-73	cyclin D1	Homo sapiens	156-165
24789436-8	2014	Moreover, pretreatment with 100 nM MG132 before IR-enhanced radiation induced cell cycle arrest by decreased CyclinD1 but increased Wee1 expression in A549 and H1299 cells.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	35-40	cyclin D1	Homo sapiens	109-117
25072246-5	2014	Since G1 arrest is a hallmark of ATRA-induced NB4 cell differentiation, we observed a decrease in G1 accumulation, as well as decreases in p21WAF1/CIP1 and cyclin D1 inductions, by ATRA in NB4MTOE cells.	Tretinoin	33-37	cyclin D1	Homo sapiens	156-165
25072246-5	2014	Since G1 arrest is a hallmark of ATRA-induced NB4 cell differentiation, we observed a decrease in G1 accumulation, as well as decreases in p21WAF1/CIP1 and cyclin D1 inductions, by ATRA in NB4MTOE cells.	Tretinoin	181-185	cyclin D1	Homo sapiens	156-165
25061736-5	2014	We also used aspirin as an inhibitor of the Wnt signaling pathway in the treatment of hepG2 cells transfected with the pReceiver-M29/thy-1 expression vector to make detailed observations of apoptosis in hepG2 cells as well as the differential expression of beta-catenin, cyclinD1, and thy-1.	Aspirin	13-20	cyclin D1	Homo sapiens	271-279
25061731-9	2014	5-Azacytidine suppressed the proliferation of pancreatic cancer cells by inhibiting the Wnt/beta-catenin signaling pathway, particularly the expression of beta-catenin, c-myc, and cyclinD1.	Azacitidine	0-13	cyclin D1	Homo sapiens	180-188
24764322-4	2014	An increase in the fluorescence intensity of cyclin D1 occurred after treatment with 0.15 and 0.3 muM doxorubicin.	Doxorubicin	102-113	cyclin D1	Homo sapiens	45-54
24764322-6	2014	Expression of CCND1 in relation to the reference gene PBGD was increased in cells exposed to 0.15 muM doxorubicin.	Doxorubicin	102-113	cyclin D1	Homo sapiens	14-19
24665856-8	2014	In addition, DAC, TSA, and gemcitabine+cisplatin combination caused an increase in GSK3beta mRNA levels, which in turn significantly decreased CCND1 mRNA levels.	Decitabine	13-16	cyclin D1	Homo sapiens	143-148
24665856-8	2014	In addition, DAC, TSA, and gemcitabine+cisplatin combination caused an increase in GSK3beta mRNA levels, which in turn significantly decreased CCND1 mRNA levels.	trichostatin A	18-21	cyclin D1	Homo sapiens	143-148
24665856-8	2014	In addition, DAC, TSA, and gemcitabine+cisplatin combination caused an increase in GSK3beta mRNA levels, which in turn significantly decreased CCND1 mRNA levels.	gemcitabine	27-38	cyclin D1	Homo sapiens	143-148
24665856-8	2014	In addition, DAC, TSA, and gemcitabine+cisplatin combination caused an increase in GSK3beta mRNA levels, which in turn significantly decreased CCND1 mRNA levels.	Cisplatin	39-48	cyclin D1	Homo sapiens	143-148
24652203-0	2014	Valproic acid inhibits the proliferation of SHSY5Y neuroblastoma cancer cells by downregulating URG4/URGCP and CCND1 gene expression.	Valproic Acid	0-13	cyclin D1	Homo sapiens	111-116
24962785-13	2014	Moreover, MRBE-induced cyclin D1 down-regulation was mediated from cyclin D1 proteasomal degradation, which was dependent on ROS.	ros	125-128	cyclin D1	Homo sapiens	23-32
24962785-13	2014	Moreover, MRBE-induced cyclin D1 down-regulation was mediated from cyclin D1 proteasomal degradation, which was dependent on ROS.	ros	125-128	cyclin D1	Homo sapiens	67-76
24932611-7	2014	Furthermore, CoCl2 treatment effectively induced the stabilization of HIF-1alpha, the differential expression of a truncated form of p53 (p47) and decreased levels of cyclin D1, indicating molecular mechanisms associated with cell cycle arrest at G2.	cobaltous chloride	13-18	cyclin D1	Homo sapiens	167-176
24760952-5	2014	Quercetin-induced cell apoptosis was shown to involve p53 and p21 up-regulation, Cyclin D1, Cdk2, and Cdk7 down-regulation.	Quercetin	0-9	cyclin D1	Homo sapiens	81-90
24760952-6	2014	These results suggested that the induction of G2/M arrest, apoptosis, and cell death by quercetin may associate with increased expression of p53 and p21, decrease of Cyclin D1, Cdk2, and Cdk7 levels, and generation of reactive oxygen species in cells.	Quercetin	88-97	cyclin D1	Homo sapiens	166-175
24735796-1	2014	BACKGROUND: Cladosporol A, a secondary metabolite from Cladosporium tenuissimum, exhibits antiproliferative properties in human colorectal cancer cells by modulating the expression of some cell cycle genes (p21(waf1/cip1), cyclin D1).	cladosporol A	12-25	cyclin D1	Homo sapiens	223-232
24764322-0	2014	Expression of cyclin D1 after treatment with doxorubicin in the HL-60 cell line.	Doxorubicin	45-56	cyclin D1	Homo sapiens	14-23
24764322-2	2014	We have followed the expression of cyclin D1 after treatment with doxorubicin with reference to cell death and other possible therapeutic implications.	Doxorubicin	66-77	cyclin D1	Homo sapiens	35-44
24753227-8	2014	Finally, we show that resveratrol increased the activities of the AP-1 responsive cyclin D1 and tumor necrosis factor alpha promoters.	Resveratrol	22-33	cyclin D1	Homo sapiens	82-123
24858998-8	2014	Furthermore, curcumin treatment led to activation of GSK-3beta, reduced expression of beta-catenin and its downstream target cyclin D1.	Curcumin	13-21	cyclin D1	Homo sapiens	125-134
24971582-8	2014	Resveratrol also abolished HG-induced phosphorylation of oxidase subunit p47 phox and reduced HG-induced cyclin D1, cyclin E, and PCNA expression in a concentration-dependent manner.	Resveratrol	0-11	cyclin D1	Homo sapiens	105-114
24695376-2	2014	2-Undecylsulfonyl-DMNQ significantly inhibited PDGF-stimulated cell number and DNA synthesis, and arrested the PDGF-stimulated progression through G0/G1 to S phase of cell cycle supported by the suppression of pRb phosphorylation and cyclin D1/E, CDK2/4 and PCNA expressions.	2-undecylsulfonyl-5,8-dimethoxy-1,4-naphthoquinone	0-22	cyclin D1	Homo sapiens	234-245
24607787-8	2014	Finally, we demonstrated that rottlerin was able to suppress the expression of cyclin D1 and survivin, two targets of both Wnt/beta-catenin and mTORC1 signaling, in prostate and breast cancer cells, and displayed remarkable anticancer activity with IC(50) values between 0.7 and 1.7 muM for prostate cancer PC-3 and DU145 cells and breast cancer MDA-MB-231 and T-47D cells.	rottlerin	30-39	cyclin D1	Homo sapiens	79-88
24563337-8	2014	ATRA treated with C-PC could induce more cell cycle arrests than the single drug used by decrease in cyclin D1 and CDK4 expression.	Tretinoin	0-4	cyclin D1	Homo sapiens	101-110
24469921-5	2014	Furthermore HIV-Tat and morphine exposure increased activation of extracellular signal-regulated kinase-1/2 (ERK1/2), enhanced levels of p53 and p21, and decreased cyclin D1 and Akt levels in NPCs.	Morphine	24-32	cyclin D1	Homo sapiens	164-173
25057056-7	2014	The expressions of beta-catenin, H3K9 and Bax proteins were significantly increased and CyclinD1, HDAC1, and HDAC3 protein expressions decreased in TSA-treated cells, but the expressions of HDAC1 and HDAC3 mRNAs showed no significant changes.	trichostatin A	148-151	cyclin D1	Homo sapiens	88-96
24878898-6	2014	At the early stage of KIOM-C treatment (12 h), cells were arrested in G1 phase, which was accompanied by up-regulation of p21 and p27, down-regulation of cyclin D1, and subsequent increases in apoptotic and autophagic cells.	kiom-c	22-28	cyclin D1	Homo sapiens	154-163
24657339-6	2014	The in vivo results further confirmed that morin by downregulating the expressions of GSK-3beta, beta-catenin and cyclin D1 ameliorated DEN-induced liver fibrosis.	Diethylnitrosamine	136-139	cyclin D1	Homo sapiens	114-123
24989281-7	2014	It is concluded that celecoxib can inhibit the proliferation of HL-60 cells in dose-dependent manner, celecoxib causes cell G0/G1 arrest and induces cell apoptosis possibly through down-regulation of the cyclin D1 and cyclin E1 expression, and down-regulation of COX-2 expression respectively.	Celecoxib	21-30	cyclin D1	Homo sapiens	204-213
24989281-7	2014	It is concluded that celecoxib can inhibit the proliferation of HL-60 cells in dose-dependent manner, celecoxib causes cell G0/G1 arrest and induces cell apoptosis possibly through down-regulation of the cyclin D1 and cyclin E1 expression, and down-regulation of COX-2 expression respectively.	Celecoxib	102-111	cyclin D1	Homo sapiens	204-213
24879546-5	2014	Ilimaquinone and ethylsmenoquinone repressed the expression of cyclin D1, c-myc, and axin-2, which are beta-catenin/T-cell factor-dependent genes, and inhibited the proliferation of multiple myeloma cells.	ilimaquinone	0-12	cyclin D1	Homo sapiens	63-72
24879546-5	2014	Ilimaquinone and ethylsmenoquinone repressed the expression of cyclin D1, c-myc, and axin-2, which are beta-catenin/T-cell factor-dependent genes, and inhibited the proliferation of multiple myeloma cells.	ethylsmenoquinone	17-34	cyclin D1	Homo sapiens	63-72
24684733-3	2014	Altered expressions of cyclin D1 and p21 were observed in MCF-7 human breast cancer cells treated with TCS and OP, which is linked to the G1/S transition of cell cycle, leading to cell proliferation.	Triclosan	103-106	cyclin D1	Homo sapiens	23-32
24727242-0	2014	Development of fluorescent double-strand probes labeled with 8-(p-CF3-cinnamyl)-adenosine for the detection of cyclin D1 breast cancer marker.	8-(p-CF3-cinnamyl)-adenosine	61-89	cyclin D1	Homo sapiens	111-120
24631288-5	2014	Simvastatin also strongly inhibited AKT activation, leading to suppression of beta-catenin activity and the expression of its targets, survivin and cyclin D1.	Simvastatin	0-11	cyclin D1	Homo sapiens	148-157
24835555-5	2014	As results, MXC and TCS induced BG-1 cell growth via regulating cyclin D1, p21 and Bax genes related with cell cycle and apoptosis.	Triclosan	20-23	cyclin D1	Homo sapiens	64-73
24804719-4	2014	The G1 arrest by piperine correlated with the down-regulation of cyclin D1 and induction of p21.	piperine	17-25	cyclin D1	Homo sapiens	65-74
24627094-0	2014	Sequential treatment of HPV E6 and E7-expressing TC-1 cells with bortezomib and celecoxib promotes apoptosis through p-p38 MAPK-mediated downregulation of cyclin D1 and CDK2.	Bortezomib	65-75	cyclin D1	Homo sapiens	155-164
24603988-5	2014	The induction of apoptosis by PM was associated with the inhibition of the pro-survival Akt, NF-kappaB and mTOR signaling proteins and their downstream intermediaries such as Foxo-3alpha and cyclin D1 (Akt); Cox-2 and VEGF (NF-kappaB); p-S6K1 and p-4E-BP1 (mTOR) as well as PKCepsilon.	pristimerin	30-32	cyclin D1	Homo sapiens	191-200
27547491-13	2014	Cyclin D1 mRNA expression by HL1-hT1 cells was suppressed when cells were cultured with 50 and 100 mM ethanol.	Ethanol	102-109	cyclin D1	Homo sapiens	0-9
24552773-7	2014	Furthermore, ponatinib abrogated the phosphorylation of beta-catenin at the site Y654, suppressed the translocation of beta-catenin, and inhibited the transcription and DNA binding of TCF and the expression of its targets (e.g., AXIN2, c-MYC, and CCND1).	ponatinib	13-22	cyclin D1	Homo sapiens	247-252
24765191-6	2014	BrMC significantly downregulated the expression of cyclin D1, cyclin E and CDK4, followed by the suppression of protein kinase B phosphorylation and downstream effectors, GSK-3beta and beta-catenin.	8-bromo-7-methoxychrysin	0-4	cyclin D1	Homo sapiens	51-60
25195259-0	2014	[Signifinace of cyclin D1 expression in CNE2 cells processed by EGCG].	epigallocatechin gallate	64-68	cyclin D1	Homo sapiens	16-25
25195259-1	2014	OBJECTIVE: To study the expression of Cyclin D1 in nasopharyngeal carcinoma cells processed by epigallocatechin gallate(EGCG) and it"s significance, and revealed the anti-tumor mechanism of EGCG against nasopharyngeal carcinoma.	epigallocatechin gallate	95-119	cyclin D1	Homo sapiens	38-47
25195259-1	2014	OBJECTIVE: To study the expression of Cyclin D1 in nasopharyngeal carcinoma cells processed by epigallocatechin gallate(EGCG) and it"s significance, and revealed the anti-tumor mechanism of EGCG against nasopharyngeal carcinoma.	epigallocatechin gallate	120-124	cyclin D1	Homo sapiens	38-47
25195259-1	2014	OBJECTIVE: To study the expression of Cyclin D1 in nasopharyngeal carcinoma cells processed by epigallocatechin gallate(EGCG) and it"s significance, and revealed the anti-tumor mechanism of EGCG against nasopharyngeal carcinoma.	epigallocatechin gallate	190-194	cyclin D1	Homo sapiens	38-47
25195259-6	2014	The expression of Cyclin D1 mRNA was down-regulated by EGCG with concentration and action time dependent (P &lt; 0.05).	epigallocatechin gallate	55-59	cyclin D1	Homo sapiens	18-27
25195259-7	2014	CONCLUSION: EGCG resisted nasopharyngeal carcinoma by inhibiting the cell proliferation, The down regulation of Cyclin D1 mRNA expression in a time and dose dependent may be the possible mechanisms.	epigallocatechin gallate	12-16	cyclin D1	Homo sapiens	112-121
23255470-3	2014	In the NuLi-1 immortalized human lung epithelial cell line with p53 and pRb deficiency, exposure to low doses of arsenic trioxide for 72 h promoted cell proliferation and upregulated the gene transcription levels of FOXM1, CDC6, CDC25A, and cyclin D1, which are both critical cell cycle regulatory genes and proto-oncogenes.	Arsenic Trioxide	113-129	cyclin D1	Homo sapiens	241-250
24627094-0	2014	Sequential treatment of HPV E6 and E7-expressing TC-1 cells with bortezomib and celecoxib promotes apoptosis through p-p38 MAPK-mediated downregulation of cyclin D1 and CDK2.	Celecoxib	80-89	cyclin D1	Homo sapiens	155-164
24627094-3	2014	In TC-1 cells sequentially treated with bortezomib and celecoxib, apoptosis was induced through decreased expression of signal transducer and activator of transcription-3 (STAT3), cyclin D1 and cyclin-dependent kinase (CDK) 2, which are major regulators of the G0/G1 cell cycle checkpoint.	Bortezomib	40-50	cyclin D1	Homo sapiens	180-189
24627094-3	2014	In TC-1 cells sequentially treated with bortezomib and celecoxib, apoptosis was induced through decreased expression of signal transducer and activator of transcription-3 (STAT3), cyclin D1 and cyclin-dependent kinase (CDK) 2, which are major regulators of the G0/G1 cell cycle checkpoint.	Celecoxib	55-64	cyclin D1	Homo sapiens	180-189
24588135-1	2014	The fungus-derived compound cephalochromin, isolated from the fermented broth of Cosmospora vilior YMJ89051501, shows growth-inhibitory and apoptotic activity against human lung cancer A549 cells in a concentration-dependent manner with an IC50 value of 2.8 muM at 48 h. Cephalochromin induced cell cycle arrest at the G0/G1 phase through down-regulation of cyclin D1, cyclin E, Cdk 2, and Cdk 4 expressions.	cephalochromin	28-42	cyclin D1	Homo sapiens	358-367
24855827-9	2014	Celecoxib inhibited the activation of STAT3 phosphorylation in HONE1 cells and the downstream genes of STAT3 (Survivin, Mcl-1, Bcl-2 and Cyclin D1) were downregulated after treatment with celecoxib.	Celecoxib	0-9	cyclin D1	Homo sapiens	137-146
25196016-5	2014	Everolimus induced cell cycle arrest at the G1 phase by downregulating cyclin D1 and upregulating p27, and increased apoptosis by downregulating Bcl-2, upregulating Bad and activating capsase-3 and poly ADP ribose polymerase.	Everolimus	0-10	cyclin D1	Homo sapiens	71-80
24522193-3	2014	Furthermore, CIIA inhibited cyclin D1 expression, as well as DNA, synthesis in response to EGF.	ciia	13-17	cyclin D1	Homo sapiens	28-37
24520077-8	2014	RNA interference-mediated silencing of TGR5 or AREG inhibited DCA-induced EGFR, MAPK, and STAT3 signaling, blunted cyclin D1 expression and cell-cycle progression, and attenuated DCA-induced colorectal cancer or PDAC tumorigenicity.	Deoxycholic Acid	62-65	cyclin D1	Homo sapiens	115-124
24481553-11	2014	Furthermore, carnosol attenuated the expression of STAT3 target gene products, such as survivin, cyclin-D1, -D2, and -D3.	carnosol	13-21	cyclin D1	Homo sapiens	97-106
24423321-9	2014	Furthermore, CLM3 inhibited epidermal growth factor receptor, AKT, and ERK1/2 phosphorylation and down-regulated cyclin D1 in 8305C and AF cells.	clm3	13-17	cyclin D1	Homo sapiens	113-122
24493576-9	2014	Fenofibrate treatment of HGG cells robustly diminished the expression of key signaling pathways, including NF-kappaB and cyclin D1.	Fenofibrate	0-11	cyclin D1	Homo sapiens	121-130
24563328-11	2014	Expression levels of CCND1, HER2, AIB1 and NCOR1 were detected as independent predictors of recurrence in this cohort of tamoxifen-treated patients.	Tamoxifen	121-130	cyclin D1	Homo sapiens	21-26
24606123-10	2014	Mutation of PR Ser345 to Ala (S345A) or inhibition of CDK2 activity using roscovitine disrupted PR/cyclin D1 interactions with DNA and blocked HSPB8 mRNA expression.	Roscovitine	74-85	cyclin D1	Homo sapiens	99-108
23567490-0	2014	The cyclin D1 (CCND1) rs9344 G&gt;A polymorphism predicts clinical outcome in colon cancer patients treated with adjuvant 5-FU-based chemotherapy.	Fluorouracil	122-126	cyclin D1	Homo sapiens	4-13
23567490-0	2014	The cyclin D1 (CCND1) rs9344 G&gt;A polymorphism predicts clinical outcome in colon cancer patients treated with adjuvant 5-FU-based chemotherapy.	Fluorouracil	122-126	cyclin D1	Homo sapiens	15-20
23567490-4	2014	Patients treated with 5-fluorouracil-based chemotherapy, carrying the CCND1 rs9344 A/A genotype had significantly decreased time-to-tumor recurrence (TTR) in univariate analysis and multivariate analysis (hazard ratio (HR) 2.47; 95% confidence interval (CI) 1.16-5.29; P=0.019).	Fluorouracil	22-36	cyclin D1	Homo sapiens	70-75
24530909-4	2014	Kirenol effectively activated the Wnt/beta-catenin signaling pathway, in which kirenol up-regulated the expression of low density lipoprotein receptor related protein 6 (LRP6), disheveled 2 (DVL2), beta-catenin, and cyclin D1 (CCND1), while it inactivated glycogen synthase kinase 3beta (GSK3beta) by increasing its phosphorylation.	kirenol	0-7	cyclin D1	Homo sapiens	216-225
24530909-4	2014	Kirenol effectively activated the Wnt/beta-catenin signaling pathway, in which kirenol up-regulated the expression of low density lipoprotein receptor related protein 6 (LRP6), disheveled 2 (DVL2), beta-catenin, and cyclin D1 (CCND1), while it inactivated glycogen synthase kinase 3beta (GSK3beta) by increasing its phosphorylation.	kirenol	0-7	cyclin D1	Homo sapiens	227-232
24530909-4	2014	Kirenol effectively activated the Wnt/beta-catenin signaling pathway, in which kirenol up-regulated the expression of low density lipoprotein receptor related protein 6 (LRP6), disheveled 2 (DVL2), beta-catenin, and cyclin D1 (CCND1), while it inactivated glycogen synthase kinase 3beta (GSK3beta) by increasing its phosphorylation.	kirenol	79-86	cyclin D1	Homo sapiens	216-225
24530909-4	2014	Kirenol effectively activated the Wnt/beta-catenin signaling pathway, in which kirenol up-regulated the expression of low density lipoprotein receptor related protein 6 (LRP6), disheveled 2 (DVL2), beta-catenin, and cyclin D1 (CCND1), while it inactivated glycogen synthase kinase 3beta (GSK3beta) by increasing its phosphorylation.	kirenol	79-86	cyclin D1	Homo sapiens	227-232
24397737-6	2014	Lycopene induced strong and sustained activation of the ERK1/2, with concomitant cyclin D1 suppression and p21 upregulation in these three cell lines.	Lycopene	0-8	cyclin D1	Homo sapiens	81-90
24366444-7	2014	Moreover, long-term EGCG treatment not only inhibited total and membranous EGFR expression, but also markedly attenuated EGFR nuclear localization and expression of the downstream target gene cyclin D1, indicating that EGCG treatment suppressed EGFR transactivation.	epigallocatechin gallate	20-24	cyclin D1	Homo sapiens	192-201
24366444-7	2014	Moreover, long-term EGCG treatment not only inhibited total and membranous EGFR expression, but also markedly attenuated EGFR nuclear localization and expression of the downstream target gene cyclin D1, indicating that EGCG treatment suppressed EGFR transactivation.	epigallocatechin gallate	219-223	cyclin D1	Homo sapiens	192-201
24552459-10	2014	Finally, silencing of ER-beta gene expression by RNA interference is able to partially reverse the effects of mibolerone on cell proliferation, p21 and cyclin D1 expression.	mibolerone	110-120	cyclin D1	Homo sapiens	152-161
24363449-5	2014	As a result, the expression of CCND1 and MCL1, proteins encoded by eIF4E-sensitive and cap-dependent transcripts, was refractory to AZD8055 in SW620:8055R cells.	(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol	132-139	cyclin D1	Homo sapiens	31-36
24380633-6	2014	C6-curcumin liposomes induced G2/M arrest and showed a combined effect in the expression levels of cyclin D1 and cyclin B1.	Curcumin	3-11	cyclin D1	Homo sapiens	99-108
24066853-7	2014	Artesunate reduced mitogen-stimulated increases in cell number and cyclin D1 protein abundance but had no significant effect on ERK1/2 phosphorylation.	Artesunate	0-10	cyclin D1	Homo sapiens	67-76
24066853-9	2014	Artesunate, but not dexamethasone, inhibited mitogen-stimulated increases in cell number, cyclin D1, and phospho-Akt protein abundance on ASM cells derived from asthmatic donors.	Artesunate	0-10	cyclin D1	Homo sapiens	90-99
23949314-0	2014	Arsenic trioxide suppressed mantle cell lymphoma by downregulation of cyclin D1.	Arsenic Trioxide	0-16	cyclin D1	Homo sapiens	70-79
23949314-4	2014	In MCL lines Jeko-1 and Granta-519, As2O3 induced dose-dependent and time-dependent increases in apoptosis accompanied by cyclin D1 suppression.	Arsenic Trioxide	36-41	cyclin D1	Homo sapiens	122-131
23949314-7	2014	Instead, As2O3 activated glycogen synthase kinase-3beta (by tyrosine-216 phosphorylation) and IkappaB kinase alpha/beta (by serine-176/180 phosphorylation), both of which phosphorylated cyclin D1 at threonine-286, leading to its poly-ubiquitination and degradation in the proteasome.	Arsenic Trioxide	9-14	cyclin D1	Homo sapiens	186-195
24327721-11	2014	Naproxen caused an accumulation of cells at the G1 phase mediated through cyclin-dependent kinase 4, cyclin D1, and p21.	Naproxen	0-8	cyclin D1	Homo sapiens	101-110
23910058-7	2014	Molecularly, LY294002 treatment down-regulated AEG-1 expression, AKT and GSK3beta phosphorylation, and expression of cyclinD1, CDK4, VEGF and Bcl2, but up-regulated Bax and c-Myc expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	cyclin D1	Homo sapiens	117-125
24248414-0	2014	miR-449a Regulates proliferation and chemosensitivity to cisplatin by targeting cyclin D1 and BCL2 in SGC7901 cells.	Cisplatin	57-66	cyclin D1	Homo sapiens	80-89
24390237-5	2014	ActinomycinD experiments revealed that AngII stabilized cyclinD1 mRNA in human mesangial cells via HuR.	Dactinomycin	0-12	cyclin D1	Homo sapiens	56-64
24293642-6	2014	The D2 receptor agonist, bromocriptine, inhibited AII-stimulated cell proliferation in primary cultures of the normal human adrenal cortex and APA through attenuating AII-induced phosphorylation of PK-stimulated cyclin D1 protein expression and cell proliferation.	Bromocriptine	25-38	cyclin D1	Homo sapiens	212-221
24333132-6	2014	KEY FINDINGS: We have demonstrated the ability of dimethyl melaleucate (DMM), a pentacyclic triterpene to exhibit cell cycle arrest at G0/G1 phase by down-regulation of cyclin D1 through PI3K/AKT inhibition.	dimethyl melaleucate	50-70	cyclin D1	Homo sapiens	169-178
24333132-6	2014	KEY FINDINGS: We have demonstrated the ability of dimethyl melaleucate (DMM), a pentacyclic triterpene to exhibit cell cycle arrest at G0/G1 phase by down-regulation of cyclin D1 through PI3K/AKT inhibition.	dimethylmyleran	72-75	cyclin D1	Homo sapiens	169-178
24333132-8	2014	Interestingly, pentacyclic triterpenes limit EGF mediated breast cancer proliferation through sustained inhibition of EGFR and its downstream effectors STAT3 and cyclin D1 in breast cancer lines.	pentacyclic	15-26	cyclin D1	Homo sapiens	162-171
24333132-8	2014	Interestingly, pentacyclic triterpenes limit EGF mediated breast cancer proliferation through sustained inhibition of EGFR and its downstream effectors STAT3 and cyclin D1 in breast cancer lines.	Triterpenes	27-38	cyclin D1	Homo sapiens	162-171
24239715-10	2014	There were significant decreases in the expression levels of p53, p21, cyclin D1 and PCNA in AA SFs treated with rhEndostatin, and a significant increase in CDK4 expression.	SFS	96-99	cyclin D1	Homo sapiens	71-80
24239715-10	2014	There were significant decreases in the expression levels of p53, p21, cyclin D1 and PCNA in AA SFs treated with rhEndostatin, and a significant increase in CDK4 expression.	rhendostatin	113-125	cyclin D1	Homo sapiens	71-80
24239715-12	2014	This is partly due to the inhibitory effect of rhEndostatin on cyclin D1 and PCNA by a p53-p21-CDK4-independent mechanism.	rhendostatin	47-59	cyclin D1	Homo sapiens	63-72
24427302-6	2014	The Wnt signaling-targeted genes, c-Myc, CCND1 and the proteins Dvl2/3, were all up-regulated in fibroblasts expressing high levels of IGFBP7, and the up-regulation could be inhibited both by the Wnt signaling antagonist Dickkopf-1 (DKK1) and by the TGF-beta1 receptor antagonist SB431542.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	280-288	cyclin D1	Homo sapiens	41-46
24416349-5	2014	We observed that the combination of RAD001 and MK-2206 exerted enhanced effects on Akt/mTOR inhibition, cyclin D1 down-regulation and ERK/MAPK(extracellular signal-regulated kinase/mitogen-activated protein kinases) activation.	MK 2206	47-54	cyclin D1	Homo sapiens	104-113
25520114-5	2014	Fisetin also suppressed nuclear translocation of NF-kappaB (p65) and IkappaBalpha phosphorylation, while inhibiting CyclinD1, all key targets of the NF-kappaB signal transduction pathway.	fisetin	0-7	cyclin D1	Homo sapiens	116-124
24998578-6	2014	Expression of ac-H3, ac-H4 and NF-kappaB/ac-p65 proteins in E2-treated MCF-7 cells was increased, this being inhibited by garcinol but not ac- H4.The nuclear translocation of NF-kappaB/p65 in E2-treated MCF-7 cells was also inhibited, along with cyclin D1, Bcl-2 and Bcl-xl in mRNA and protein expression levels.	garcinol	122-130	cyclin D1	Homo sapiens	246-255
24568493-0	2014	Fangchinoline inhibits cell proliferation via Akt/GSK-3beta/ cyclin D1 signaling and induces apoptosis in MDA-MB-231 breast cancer cells.	fangchinoline	0-13	cyclin D1	Homo sapiens	61-70
23983146-8	2014	In addition, neferine could induce p53 and its effector protein p21 and downregulation of cell cycle regulatory protein cyclin D1 thereby inducing G1 cell cycle arrest.	neferine	13-21	cyclin D1	Homo sapiens	120-129
24036327-8	2014	Moreover, GW9662 and PPARgamma siRNA also significantly attenuated the up-regulation of p21 and down-regulation of cyclin D1 caused by carotenoids and rosiglitazone.	Rosiglitazone	151-164	cyclin D1	Homo sapiens	115-124
24036327-9	2014	CONCLUSIONS: PPARgamma signaling pathway, via stimulating p21 and inhibiting cyclin D1, may play an important role in the anti-proliferative effects of carotenoid and rosiglitazone combination on K562 cells.	Carotenoids	152-162	cyclin D1	Homo sapiens	77-86
24036327-9	2014	CONCLUSIONS: PPARgamma signaling pathway, via stimulating p21 and inhibiting cyclin D1, may play an important role in the anti-proliferative effects of carotenoid and rosiglitazone combination on K562 cells.	Rosiglitazone	167-180	cyclin D1	Homo sapiens	77-86
24134204-0	2014	A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3beta to phosphorylate cyclin D1 at Thr(286), not Thr(288).	AZ191	25-30	cyclin D1	Homo sapiens	104-113
24134204-0	2014	A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3beta to phosphorylate cyclin D1 at Thr(286), not Thr(288).	Threonine	117-120	cyclin D1	Homo sapiens	104-113
24134204-3	2014	CCND1 (cyclin D1), a key regulator of the mammalian G1-S-phase transition, is phosphorylated on Thr(286) by GSK3beta (glycogen synthase kinase 3beta) to promote its degradation.	Threonine	96-99	cyclin D1	Homo sapiens	0-5
24134204-3	2014	CCND1 (cyclin D1), a key regulator of the mammalian G1-S-phase transition, is phosphorylated on Thr(286) by GSK3beta (glycogen synthase kinase 3beta) to promote its degradation.	Threonine	96-99	cyclin D1	Homo sapiens	7-16
24134204-5	2014	Using in vitro kinase assays, phospho-specific immunoblot analysis and MS in conjunction with AZ191 we now show that DYRK1B phosphorylates CCND1 at Thr(286), not Thr(288), in vitro and in cells.	Threonine	148-151	cyclin D1	Homo sapiens	139-144
24134204-8	2014	The results of the present study demonstrate for the first time that DYRK1B is a novel Thr(286)-CCND1 kinase that acts independently of GSK3beta to promote CCND1 degradation.	Threonine	87-90	cyclin D1	Homo sapiens	96-101
24134204-8	2014	The results of the present study demonstrate for the first time that DYRK1B is a novel Thr(286)-CCND1 kinase that acts independently of GSK3beta to promote CCND1 degradation.	Threonine	87-90	cyclin D1	Homo sapiens	156-161
24812621-4	2014	Treatment of pancreatic cancer BxPc-3 and Panc-1 cells with alpha -mangostin resulted in loss of cell viability, accompanied by enhanced cell apoptosis, cell cycle arrest at G1 phase, and decrease of cyclin-D1.	mangostin	60-76	cyclin D1	Homo sapiens	200-209
25268087-11	2014	In addition, saikosaponin-d administration led to a significant up-regulation of p21 and down-regulation of CDK2 and cyclin D1.	saikosaponin D	13-27	cyclin D1	Homo sapiens	117-126
24812569-9	2014	In addition, cyclin D1 was significantly decreased in TCE-treated cells.	Trichloroethylene	54-57	cyclin D1	Homo sapiens	13-22
24692711-4	2014	Nobiletin induced cell-cycle arrest at the G0/G1 phase by suppressing ERK1/2 activity, with concomitant cyclin-D1 suppression and p21 up-regulation.	nobiletin	0-9	cyclin D1	Homo sapiens	104-113
24635079-8	2014	ATRA also induced G1 cell-cycle arrest, inhibited the expression of cyclin D1/cyclin-dependent kinase (CDK)4 and cyclinE/CDK2, and increased the expression of the cyclin-dependent kinase inhibitors p21 and p27.	Tretinoin	0-4	cyclin D1	Homo sapiens	68-77
24508477-8	2014	In addition, acrylamide raised expression of epidermal growth factor receptor (EGFR), cyclin D1 and nuclear factor-kappaB (NF-kappaB), which contributed to cell proliferation.	Acrylamide	13-23	cyclin D1	Homo sapiens	86-121
24508477-9	2014	Both curcumin and EGCG effectively reduced acrylamide-induced proliferation, as well as protein expression of CYP2E1, EGFR, cyclin D1 and NF-kappaB.	Curcumin	5-13	cyclin D1	Homo sapiens	124-133
24508477-9	2014	Both curcumin and EGCG effectively reduced acrylamide-induced proliferation, as well as protein expression of CYP2E1, EGFR, cyclin D1 and NF-kappaB.	epigallocatechin gallate	18-22	cyclin D1	Homo sapiens	124-133
24763006-8	2014	The apoptotic rate of U266 cells increased in dose and time dependent manners; after treatment of U266 cells with oridonin the mRNA levels of FGFR3, BCL2, CCND1 and MYC as well as the their protein levels decreased.	oridonin	114-122	cyclin D1	Homo sapiens	155-160
24678876-12	2014	In addition, calcitriol-treated cells in the presence of ICI-182,780 resulted in a significant reduction of two important cell proliferation regulators CCND1 and EAG1.	Calcitriol	13-23	cyclin D1	Homo sapiens	152-157
24373949-4	2014	We found that cAMP increased DNA synthesis and cyclin D1 expression in somatotropinomas, whereas it reduced both parameters in prolactinomas and nonfunctioning adenomas, these effects being replicated in corresponding cell lines.	Cyclic AMP	14-18	cyclin D1	Homo sapiens	47-56
24603539-7	2014	Additionally, the increase in proliferation and cyclin D1 expression induced by miR-21 overexpression was almost completely blocked by Ly294002, an AKT inhibitor.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	135-143	cyclin D1	Homo sapiens	48-57
24424498-9	2014	It was also shown that 6-shogaol combined with gemcitabine treatment was more effective than drug alone, consistent with the downregulation of NF-kappaB activity along with its target genes COX-2, cyclinD1, survivin, cIAP-1, and XIAP.	shogaol	23-32	cyclin D1	Homo sapiens	197-205
24424498-9	2014	It was also shown that 6-shogaol combined with gemcitabine treatment was more effective than drug alone, consistent with the downregulation of NF-kappaB activity along with its target genes COX-2, cyclinD1, survivin, cIAP-1, and XIAP.	gemcitabine	47-58	cyclin D1	Homo sapiens	197-205
24464048-10	2014	Furthermore, both OSU-CG5 and resveratrol induced dose-dependent energy restriction in the cells: they suppressed glucose uptake and Akt phosphorylation, decreased the levels of p-mTOR and p-p70S6K, increased the levels of ER stress response proteins GRP78 and GADD153, and increased the level of beta-TrCP, which led to the downregulation of cyclin D1 and Sp1.	OSU-CG5	18-25	cyclin D1	Homo sapiens	343-352
24464048-10	2014	Furthermore, both OSU-CG5 and resveratrol induced dose-dependent energy restriction in the cells: they suppressed glucose uptake and Akt phosphorylation, decreased the levels of p-mTOR and p-p70S6K, increased the levels of ER stress response proteins GRP78 and GADD153, and increased the level of beta-TrCP, which led to the downregulation of cyclin D1 and Sp1.	Resveratrol	30-41	cyclin D1	Homo sapiens	343-352
23884787-4	2014	We found that EGCG treatment results in increased expression of KLF4 and alters expression of the KLF4 target genes p21, CDK4, and cyclin D1.	epigallocatechin gallate	14-18	cyclin D1	Homo sapiens	131-140
24637250-8	2014	The results indicated that CIT inhibited HUVECs proliferation and the cells were arrested at G0/G1 phase, which is associated with decreased levels of cyclinD1 and increased expression of p53 and p21.	citreoviridin	27-30	cyclin D1	Homo sapiens	151-159
23934681-7	2014	We also found that GW9662 attenuated OA-induced upregulation of C/EBPbeta, an important regulator of leukemic differentiation, and p21, which is a potent inhibitor of CDKs that can inhibit phosphorylation of Rb by cyclin D1-CDK4 complexes.	2-chloro-5-nitrobenzanilide	19-25	cyclin D1	Homo sapiens	214-223
24744797-2	2014	In this study, we examined the relationship between cyclin D1 overexpression and disease-specific survival (DSS).	dss	108-111	cyclin D1	Homo sapiens	52-61
24744797-7	2014	Cyclin D1 overexpression was significantly associated with longer DSS (5-year DSS, 89.9% in patients without cyclin D1 overexpression vs. 98.9% in patients with cyclin D1 overexpression; p=0.008).	dss	66-69	cyclin D1	Homo sapiens	0-9
24744797-7	2014	Cyclin D1 overexpression was significantly associated with longer DSS (5-year DSS, 89.9% in patients without cyclin D1 overexpression vs. 98.9% in patients with cyclin D1 overexpression; p=0.008).	dss	78-81	cyclin D1	Homo sapiens	0-9
24744797-11	2014	CONCLUSION: Cyclin D1 overexpression is associated with longer DSS, but not recurrence-free survival, in patients with breast cancer.	dss	63-66	cyclin D1	Homo sapiens	12-21
24233024-6	2014	Simvastatin suppressed the proliferation of gastric cancer cells, enhanced the apoptotic effects of capecitabine, suppressed the constitutive activation of NF-kappaB, and abrogated the expression of cyclooxygenase-2 (COX-2), cyclin D1, Bcl-2, survivin, CXC motif receptor 4, and MMP-9 proteins.	Simvastatin	0-11	cyclin D1	Homo sapiens	225-234
24233024-8	2014	As compared to the vehicle control, simvastatin also suppressed the expression of NF-kappaB-regulated gene products such as cyclin D1, COX-2, ICAM-1, MMP-9, survivin, Bcl-xL, and XIAP in tumor tissues.	Simvastatin	36-47	cyclin D1	Homo sapiens	124-133
24342356-5	2014	Further studies showed that SUMOylation at Lys-138 was critical for RhoGDIalpha down-regulation of cyclin D1 protein expression and that MEK1/2-Erk was a specific downstream target of SUMOylated RhoGDIalpha for its inhibition of C-Jun/AP-1 cascade, cyclin d1 transcription, and cell cycle progression.	Lysine	43-46	cyclin D1	Homo sapiens	99-108
24868967-1	2014	OBJECTIVE: To investigate the roles of p53 in the interaction of p21, cyclin D1 and CDK4 in human embryonic lung fibroblasts (HELFs) induced by benzo (a) pyrene.	Benzo(a)pyrene	144-160	cyclin D1	Homo sapiens	70-79
24577313-10	2014	Furthermore, the HBx-induced increases in cyclin D1 expression and oval cell proliferation were completely abolished by treatment with either MEK inhibitor PD184352 or PI-3K inhibitor LY294002.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	156-164	cyclin D1	Homo sapiens	42-51
24577313-10	2014	Furthermore, the HBx-induced increases in cyclin D1 expression and oval cell proliferation were completely abolished by treatment with either MEK inhibitor PD184352 or PI-3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	184-192	cyclin D1	Homo sapiens	42-51
24615109-4	2014	The immunohistochemical SP method was used to detect cyclin D1 and survivin protein expression levels.	TFF2 protein, human	24-26	cyclin D1	Homo sapiens	53-62
24688409-4	2014	The protein and mRNA levels of cyclin D1 decreased gradually with the increasing of thapsigargin concentration and treatment times.	Thapsigargin	84-96	cyclin D1	Homo sapiens	31-40
24688409-5	2014	Moreover, the protein levels of mTORC1 downstream indicators pS6K and p4EBP-1 were reduced by thapsigargin treatment at different concentrations and times, which should be responsible for the reduced cyclin D1 expressions.	Thapsigargin	94-106	cyclin D1	Homo sapiens	200-209
24487688-6	2014	The 17beta-estradiol (E2)-induced expression of pS2 and cyclin D1, ER-alpha target gene products, was also decreased in the presence of DATS.	Estradiol	4-20	cyclin D1	Homo sapiens	56-65
24487688-6	2014	The 17beta-estradiol (E2)-induced expression of pS2 and cyclin D1, ER-alpha target gene products, was also decreased in the presence of DATS.	diallyl trisulfide	136-140	cyclin D1	Homo sapiens	56-65
24475272-9	2014	Transient transfection of c-myc inhibited the down-regulation of both cyclin D1 and cyclin E protein expression to reevesioside A action, suggesting that c-myc functioned as an upstream regulator.	reevesioside A	115-129	cyclin D1	Homo sapiens	70-79
24475272-11	2014	In summary, the data suggest that reevesioside A inhibits c-myc expression and down-regulates the expression of CDC25A, cyclin D1 and cyclin E, leading to a profound decrease of RB phosphorylation.	reevesioside A	34-48	cyclin D1	Homo sapiens	120-129
24178620-0	2014	Antitumoral activity of lenalidomide in in vitro and in vivo models of mantle cell lymphoma involves the destabilization of cyclin D1/p27KIP1 complexes.	Lenalidomide	24-36	cyclin D1	Homo sapiens	124-133
24178620-2	2014	We investigated whether the expression and subcellular localization of cyclin D1, a major cell-cycle regulator overexpressed in MCL, and the cyclin-dependent kinase inhibitor p27(KIP1), could identify MCL cases sensitive to lenalidomide, and whether the compound could modulate cyclin D1/p27(KIP1) complexes in MCL cells.	Lenalidomide	224-236	cyclin D1	Homo sapiens	71-80
24178620-4	2014	Activity of lenalidomide in vitro and its effect on cyclin D1/p27(KIP1) complexes were evaluated by real-time PCR, immunoprecipitation, immunofluorescence, and Western blot.	Lenalidomide	12-24	cyclin D1	Homo sapiens	52-61
24178620-9	2014	Lenalidomide mechanism of action relied on cyclin D1 downregulation and disruption of cyclin D1/p27(KIP1) complexes, followed by cytosolic accumulation of p27(KIP1), cell proliferation arrest, apoptosis, and angiogenesis inhibition.	Lenalidomide	0-12	cyclin D1	Homo sapiens	43-52
24178620-9	2014	Lenalidomide mechanism of action relied on cyclin D1 downregulation and disruption of cyclin D1/p27(KIP1) complexes, followed by cytosolic accumulation of p27(KIP1), cell proliferation arrest, apoptosis, and angiogenesis inhibition.	Lenalidomide	0-12	cyclin D1	Homo sapiens	86-95
24178620-10	2014	CONCLUSIONS: These results highlight a mechanism of action of lenalidomide in MCL cases with increased tumorigenicity in vivo, which is mediated by the dissociation of cyclin D1/p27(KIP1) complexes, and subsequent proliferation blockade and apoptosis induction.	Lenalidomide	62-74	cyclin D1	Homo sapiens	168-177
24418169-7	2014	Combination of sorafenib and YC-1 significantly inhibited the expression of p-STAT3 (Y705) (S727), p-ERK1/2, cyclin D1 and survivin and SHP-1 activity compared with sorafenib or YC-1 used alone in all tested HCC cell lines.	Sorafenib	15-24	cyclin D1	Homo sapiens	109-118
24418169-11	2014	The reduced expression of p-STAT3, cyclin D1 and survivin was also observed with the combination of sorafenib and YC-1.	Sorafenib	100-109	cyclin D1	Homo sapiens	35-44
24467547-3	2014	FUR concentration-dependently inhibited cell proliferation and blocked the cell cycle progressions in G1 phase by down-regulating the protein levels of cyclin D1 and CDK6, and up-regulating those of p21 and p27 in 95-D cells.	furanodiene	0-3	cyclin D1	Homo sapiens	152-161
24870761-8	2014	RT-PCR demonstrated that NF-xBp65 and cyclin D1 mRNA expression was significantly down-regulated in 7901 cells treated with 2.0 mg/ml TMP for 72h (p&lt;0.05), while the p16 mRNA level was up-regulated (p&lt;0.05).	tmp	134-137	cyclin D1	Homo sapiens	38-47
24870761-9	2014	The protein expression of NF-xBp65 and cyclin D1 decreased gradually with the increase in TMP concentration, compared with control cells (p&lt;0.05), while expression of protein p16 was up-regulated (p&lt;0.01).	tmp	90-93	cyclin D1	Homo sapiens	39-48
25374189-6	2014	In E-cancer cells exposed to nanoliposomal quercetin (nLQ with cytomembrane permeability), down-regulation of NF-kappaBp65, histone deacetylase 1 (HDAC1) and cyclin D1 and up-regulation of caspase-3 were shown by immunoblotting, and attenuated HDAC1 with nuclear translocation and promoted E-cadherin expression were demonstrated by immunocytochemistry.	Quercetin	43-52	cyclin D1	Homo sapiens	158-167
24036327-8	2014	Moreover, GW9662 and PPARgamma siRNA also significantly attenuated the up-regulation of p21 and down-regulation of cyclin D1 caused by carotenoids and rosiglitazone.	Carotenoids	135-146	cyclin D1	Homo sapiens	115-124
25221777-5	2014	Furthermore, our data indicate that BTB can modulate ER transactivation and suppress the expression of E2-mediated ER target genes (Cyclin D1, E2F1, and TERT) in the ER-positive MCF-7, Ishikawa, and SKOV-3 cells.	btb	36-39	cyclin D1	Homo sapiens	132-141
24007863-8	2014	Mechanistically, compared with 5-FU alone, the combination more noticeably downregulated EGFR phosphorylation and Akt phosphorylation as well as the expression of the apoptotic protector Bcl-xL and the cell cycle regulator cyclin D1.	Fluorouracil	31-35	cyclin D1	Homo sapiens	223-232
25301361-0	2014	Formononetin promotes cell cycle arrest via downregulation of Akt/Cyclin D1/CDK4 in human prostate cancer cells.	formononetin	0-12	cyclin D1	Homo sapiens	66-75
25301361-6	2014	Next, formononetin-induced alterations in cyclin D1, CDK4 and Akt expression in PC-3 cells were detected by real-time PCR and western blot.	formononetin	6-18	cyclin D1	Homo sapiens	42-51
25301361-8	2014	Meanwhile, concomitant with reduced phosphorylation of Akt in PC-3 cells, formononetin remarkably downregulated expression levels of cyclin D1 and CDK4 in a dose-dependent manner.	formononetin	74-86	cyclin D1	Homo sapiens	133-142
25301361-10	2014	CONCLUSION: Formononetin could exhibit inhibitory activity against human prostate cancer cells in vivo and in vitro, which is associated with G1 cell cycle arrest by inactivation of Akt/cyclin D1/CDK4.	formononetin	12-24	cyclin D1	Homo sapiens	186-195
24738643-3	2014	The ratio of phospharylated eIF-2alpha to dephospharylated eIF-2alpha increased, whereas cyclin D1 decreased significantly under combined treatment of tetrandrine (5 muM) and caffeine (1 mM).	tetrandrine	151-162	cyclin D1	Homo sapiens	89-98
25358426-0	2014	Bcl1 polymorphism of the glucocorticoid receptor gene and treatment response to milnacipran and fluvoxamine in Japanese patients with depression.	Milnacipran	80-91	cyclin D1	Homo sapiens	0-4
25358426-0	2014	Bcl1 polymorphism of the glucocorticoid receptor gene and treatment response to milnacipran and fluvoxamine in Japanese patients with depression.	Fluvoxamine	96-107	cyclin D1	Homo sapiens	0-4
25358426-2	2014	The purpose of this study was to investigate whether Bcl1 polymorphisms of GRs are associated with the antidepressant effect of milnacipran, a serotonin noradrenaline reuptake inhibitor (SNRI), and fluvoxamine, a selective serotonin reuptake inhibitor (SSRI), in Japanese patients with depression.	Milnacipran	128-139	cyclin D1	Homo sapiens	53-57
25358426-2	2014	The purpose of this study was to investigate whether Bcl1 polymorphisms of GRs are associated with the antidepressant effect of milnacipran, a serotonin noradrenaline reuptake inhibitor (SNRI), and fluvoxamine, a selective serotonin reuptake inhibitor (SSRI), in Japanese patients with depression.	Fluvoxamine	198-209	cyclin D1	Homo sapiens	53-57
25358426-7	2014	However, when milnacipran- and fluvoxamine-treated subjects were analyzed independently, patients with G allele in Bcl1 polymorphism had a significantly better response to fluvoxamine than those with C/C genotype.	Milnacipran	14-25	cyclin D1	Homo sapiens	115-119
25358426-7	2014	However, when milnacipran- and fluvoxamine-treated subjects were analyzed independently, patients with G allele in Bcl1 polymorphism had a significantly better response to fluvoxamine than those with C/C genotype.	Fluvoxamine	31-42	cyclin D1	Homo sapiens	115-119
25358426-7	2014	However, when milnacipran- and fluvoxamine-treated subjects were analyzed independently, patients with G allele in Bcl1 polymorphism had a significantly better response to fluvoxamine than those with C/C genotype.	Fluvoxamine	172-183	cyclin D1	Homo sapiens	115-119
24213303-6	2014	Western blot analysis revealed that sorafenib upregulated the expression of cyclin D1 and cyclin-dependent kinase 2 and downregulated the expression of BAX at this specific point.	Sorafenib	36-45	cyclin D1	Homo sapiens	76-85
24213303-7	2014	Furthermore, sorafenib was confirmed to regulate the expression of cyclin D1 and apoptosis-associated proteins through the regulation of extracellular signal-regulated kinase 1/2 phosphorylation in A549 cells.	Sorafenib	13-22	cyclin D1	Homo sapiens	67-76
24660968-5	2014	After LPAE treatment, the proliferation and colony formation of cancer cells decreased; apoptotic cells increased; DNA fragmentations were evident; mRNA and protein expressions of PPARgamma, Bax, and caspase-3 genes increased and expressions of cyclin D1 and Bcl-2 genes decreased; in vivo experiment, LPAE inhibited human beast cancer growth.	lpae	6-10	cyclin D1	Homo sapiens	245-254
24660968-6	2014	The findings in this experimental study suggested that LPAE has potential cytotoxic and apoptotic effects on human breast cancer cells in vitro and inhibits the cancer growth in vivo, and its mechanism of activity might be associated with apoptosis induction of cancer cells through upregulation of the mRNA and protein expressions of PPARgamma, Bax, and capase-3 genes and downregulation of the expressions of cyclin D1 and Bcl-2 genes.	lpae	55-59	cyclin D1	Homo sapiens	411-420
24738643-3	2014	The ratio of phospharylated eIF-2alpha to dephospharylated eIF-2alpha increased, whereas cyclin D1 decreased significantly under combined treatment of tetrandrine (5 muM) and caffeine (1 mM).	Caffeine	175-183	cyclin D1	Homo sapiens	89-98
24738643-6	2014	In conclusion, tetrandrine and caffeine could induce glioma cell death possibly via increasing eIF-2alpha phospharylation, decreasing cyclin-D1 expression, and increasing caspase-dependent and -independent apoptosis pathways.	tetrandrine	15-26	cyclin D1	Homo sapiens	134-143
24738643-6	2014	In conclusion, tetrandrine and caffeine could induce glioma cell death possibly via increasing eIF-2alpha phospharylation, decreasing cyclin-D1 expression, and increasing caspase-dependent and -independent apoptosis pathways.	Caffeine	31-39	cyclin D1	Homo sapiens	134-143
25132913-4	2014	This study aimed to elucidate the modulatory role of tocotrienol-rich fraction (TRF) on SA-miRNAs (miR-20a, miR-24, miR-34a, miR-106a, and miR-449a) and established target genes of miR-34a (CCND1, CDK4, and SIRT1) during replicative senescence of human diploid fibroblasts (HDFs).	Tocotrienols	53-64	cyclin D1	Homo sapiens	190-195
23888319-3	2014	Our results found that curcumin inhibited cell proliferation, which was associated with upregulation of the cyclin-dependent kinase inhibitors, p27 and p21, and downregulation of cyclin D1.	Curcumin	23-31	cyclin D1	Homo sapiens	179-188
24601221-9	2014	GDC-0941 downregulated the key components of the cell cycle machinery, such as cyclin D1, upregulated the apoptotic markers and inhibited cell motility on three cell lines with PIK3CA Mutation or HER2 amplification.	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	0-8	cyclin D1	Homo sapiens	79-88
24118288-7	2013	In human prostate cancer cell line LNCaP, apocynin also inhibited reactive oxygen species production and blocked cell growth by inducing G0/G1 arrest with downregulation of clusterin and cyclin D1.	acetovanillone	42-50	cyclin D1	Homo sapiens	187-196
24351837-4	2013	Metformin significantly inhibited the proliferation and colony formation of 5637 and T24 cells in vitro; specifically, metformin induced an apparent cell cycle arrest in G0/G1 phases, accompanied by a strong decrease of cyclin D1, cyclin-dependent kinase 4 (CDK4), E2F1 and an increase of p21waf-1.	Metformin	119-128	cyclin D1	Homo sapiens	220-229
24351837-6	2013	Moreover, daily treatment of metformin led to a substantial inhibition of tumor growth in a xenograft model with concomitant decrease in the expression of proliferating cell nuclear antigen (PCNA), cyclin D1 and p-mTOR.	Metformin	29-38	cyclin D1	Homo sapiens	198-207
24367492-3	2013	CCND1 (cyclin D1) gene amplification is a putative candidate tamoxifen predictive biomarker.	Tamoxifen	61-70	cyclin D1	Homo sapiens	0-5
24367492-3	2013	CCND1 (cyclin D1) gene amplification is a putative candidate tamoxifen predictive biomarker.	Tamoxifen	61-70	cyclin D1	Homo sapiens	7-16
24012435-7	2013	These results correlated with up-regulation of the proliferative and survival pathways ERKs and Akt and with cell cycle re-activation via induction of CyclinD1 and phosphorylation of Rb, following PL stimulation.	pl	197-199	cyclin D1	Homo sapiens	151-159
24330704-10	2013	Eugenol inhibited also several other breast cancer related oncogenes, such as NF-kappaB and cyclin D1.	Eugenol	0-7	cyclin D1	Homo sapiens	92-101
24324713-4	2013	Icaritin inhibited both constitutive and IL-6-induced phospho-STAT3 (STAT3(Y705)) and reduced the level of STAT3-regulated proteins Bcl-xL, Mcl-1, Survivin, and CyclinD1 in a dose-dependent manner.	icaritin	0-8	cyclin D1	Homo sapiens	161-169
23848205-0	2013	Curcumin potentiates the ability of sunitinib to eliminate the VHL-lacking renal cancer cells 786-O: rapid inhibition of Rb phosphorylation as a preamble to cyclin D1 inhibition.	Curcumin	0-8	cyclin D1	Homo sapiens	157-166
23848205-0	2013	Curcumin potentiates the ability of sunitinib to eliminate the VHL-lacking renal cancer cells 786-O: rapid inhibition of Rb phosphorylation as a preamble to cyclin D1 inhibition.	Sunitinib	36-45	cyclin D1	Homo sapiens	157-166
23848205-8	2013	Although the levels of cyclin D1 did not change in 8 hours, its expression was dramatically inhibited after 24 hours of SunC exposure.	sunc	120-124	cyclin D1	Homo sapiens	23-32
23848205-9	2013	Since curcumin is known to inhibit the cyclin D1-dependent G1/S-phase kinase CDK4 and the cyclin B-dependent G2/M-phase kinase CDK1 that catalyze phosphorylation-mediated inactivation of Rb, our results indicate that SunC containing a lower dose of sunitinib would be effective in restoring the tumor suppressor activity of Rb, thereby truncating cell cycle and triggering cell death.	Curcumin	6-14	cyclin D1	Homo sapiens	39-48
23803693-3	2013	Treatment of Panc1, L3.6pL and Panc28 pancreatic cancer cells with metformin downregulated Sp1, Sp3 and Sp4 proteins and several pro-oncogenic Sp-regulated genes including bcl-2, survivin, cyclin D1, vascular endothelial growth factor and its receptor, and fatty acid synthase.	Metformin	67-76	cyclin D1	Homo sapiens	189-198
24064724-3	2013	We identified that curcumin interrupts wnt signaling by decreasing beta-catenin activity, which in turn suppresses the expression of beta-catenin target genes (c-myc, VEGF and cyclin D1).	Curcumin	19-27	cyclin D1	Homo sapiens	176-185
24065300-4	2013	Following treatment of the hepatocellular carcinoma cell lines BEL-7402 and QGY-7703 with EGCG, in vitro, EGCG significantly suppressed cell proliferation as detected by MTT assay, induced apoptosis as detected by flow cytometry, dramatically lowered the expression levels of phosphorylated Stat3 proteins (p-Stat3) as determined by immunoblot detection, and inhibited the expression of multiple genes including Bcl-xL, c-Myc, VEGF and cyclin D1 as demonstrated by RT-PCR analysis.	epigallocatechin gallate	90-94	cyclin D1	Homo sapiens	436-445
24065300-4	2013	Following treatment of the hepatocellular carcinoma cell lines BEL-7402 and QGY-7703 with EGCG, in vitro, EGCG significantly suppressed cell proliferation as detected by MTT assay, induced apoptosis as detected by flow cytometry, dramatically lowered the expression levels of phosphorylated Stat3 proteins (p-Stat3) as determined by immunoblot detection, and inhibited the expression of multiple genes including Bcl-xL, c-Myc, VEGF and cyclin D1 as demonstrated by RT-PCR analysis.	epigallocatechin gallate	106-110	cyclin D1	Homo sapiens	436-445
23420757-4	2013	Western blotting showed that cajanol modulated the ERalpha-dependent PI3K pathway and induced the activation of GSK3 and CyclinD1 closely following the profile of PI3K activity.	cajanol	29-36	cyclin D1	Homo sapiens	121-129
23401195-5	2013	In addition, upon analysis of expression of cell cycle-related proteins, we found that Fangchinoline reduced expression of cyclin D1, cyclin D3, and cyclin E, and increased expression of the cyclin-dependent kinase (CDK) inhibitors, p21/WAF1, and p27/KIP1.	fangchinoline	87-100	cyclin D1	Homo sapiens	123-132
23857284-6	2013	The impact of miRNA-21 on the expression of cyclin D1, caspase-3, and matrix metalloprotease-9 (MMP9) was also studied.	mirna-21	14-22	cyclin D1	Homo sapiens	44-53
23907579-4	2013	The result showed that the proliferation rate and colony-forming abilities of gastric cancer cells were significantly suppressed by DHA together with significant suppression of the expressions of proliferation markers (PCNA, cyclin E, and cyclin D1), and upregulation of p21 and p27.	artenimol	132-135	cyclin D1	Homo sapiens	239-248
24060681-0	2013	Activation of P27kip1-cyclin D1/E-CDK2 pathway by polysaccharide from Phellinus linteus leads to S-phase arrest in HT-29 cells.	Polysaccharides	50-64	cyclin D1	Homo sapiens	22-31
24273411-11	2013	Cyclin D1 was upregulated in the presence of Wnt3a and downregulated with addition of niclosamide.	Niclosamide	86-97	cyclin D1	Homo sapiens	0-9
24091631-6	2013	Co-IP assay confirmed that this DeltaE2 protein lost CCND1- and RB1-binding ability.	co-ip	0-5	cyclin D1	Homo sapiens	53-58
24044882-0	2013	Molecular targeting of Akt by thymoquinone promotes G(1) arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells.	thymoquinone	30-42	cyclin D1	Homo sapiens	98-107
24301913-3	2013	We aimed to determine the efficacy of panobinostat, alone and in combination with cisplatin, on cell survival and mRNA expression of FOXO3A, CCND1, and CASP9 genes in both mesothelioma and healthy mesothelial cell lines.	Panobinostat	38-50	cyclin D1	Homo sapiens	141-146
24299604-9	2013	RT-PCR and immunoblot studies revealed that myricanone activated the apoptotic signalling cascades through down-regulation of transcription factors like nuclear factor-kappaB (NF-kappaB) (p65), and signal transducers and activators of transcription 3 (STAT3); cell cycle regulators like cyclin D1, and survivin and other signal proteins like Bcl-2 and up-regulation of Bax, caspase-9 and caspase-3.	myricanone	44-54	cyclin D1	Homo sapiens	287-296
24013885-7	2013	Western and qRT-PCR analysis showed that diclofenac and celecoxib reduced the expression of beta-catenin target genes Axin2, cyclin D1 and c-Myc.	Diclofenac	41-51	cyclin D1	Homo sapiens	125-134
24013885-7	2013	Western and qRT-PCR analysis showed that diclofenac and celecoxib reduced the expression of beta-catenin target genes Axin2, cyclin D1 and c-Myc.	Celecoxib	56-65	cyclin D1	Homo sapiens	125-134
24008375-0	2013	Metformin suppresses hepatocellular carcinoma cell growth through induction of cell cycle G1/G0 phase arrest and p21CIP and p27KIP expression and downregulation of cyclin D1 in vitro and in vivo.	Metformin	0-9	cyclin D1	Homo sapiens	164-173
24008375-13	2013	Treatment with metformin upregulated the expression of p21CIP and p27KIP, but downregulated cyclin D1 levels, both in vitro and in vivo.	Metformin	15-24	cyclin D1	Homo sapiens	92-101
23958494-8	2013	However, when simultaneous to AZA treatment the autophagy was inhibited by bafilomycin A1 and the degradation of regulatory proteins of cell cycle (e.g. Rb, E2F, and cyclin D1) provoked apoptosis.	Azathioprine	30-33	cyclin D1	Homo sapiens	166-175
24331695-9	2013	Sorafenib alone induced G1 phase arrest (increasing from 44.73% +/- 1.63% to 65.80% +/- 0.56%; P less than 0.001) and significantly decreased the proportion of cells in S phase (decreasing from 46.63% +/- 0.65% to 22.83% +/- 1.75%; P less than 0.01), as well as down-regulated cyclinD1 expression (0.57 +/- 0.03-fold change vs. untreated control group; P less than 0.01).	Sorafenib	0-9	cyclin D1	Homo sapiens	277-285
24331695-10	2013	5-FU alone up-regulated cyclinD1 expression (1.45 +/- 0.12-fold change vs. untreated control group; P less than 0.01).	Fluorouracil	0-4	cyclin D1	Homo sapiens	24-32
24100731-0	2013	Lentivirus-mediated shRNA targeting of cyclin D1 enhances the chemosensitivity of human gastric cancer to 5-fluorouracil.	Fluorouracil	106-120	cyclin D1	Homo sapiens	39-48
24100731-6	2013	In this study, we investigated whether treatment of gastric cancer cells with shRNA targeting cyclin D1 (ShCCND1) or 5-FU, alone or in combination, influences the activation of phosphorylated AKT (pAKT) and pNFkappaB, which are markers that are increased in 5-FU chemoresistance.	Fluorouracil	258-262	cyclin D1	Homo sapiens	94-103
24100924-11	2013	Patients with high cyclin D1 expressing tumors demonstrated improved TTP on erlotinib (8.2 vs. 4.7 months; hazard ratio, 4.1; 95% CI, 1.6-0.6; P=0.003) and improved OS (20.5 vs. 8.0 months; hazard ratio 2.8; 95% CI, 1.2-6.3; P=0.016).	Erlotinib Hydrochloride	76-85	cyclin D1	Homo sapiens	19-28
24236210-7	2013	Cd promoted cell cycle progression by increasing cyclins D1, D3 and c-fos expression.	Cadmium	0-2	cyclin D1	Homo sapiens	49-63
24244623-6	2013	Our results showed that in HK-2 cells combined treatment with Cyclosporine A + nerve growth factor induced a significant reduction in cell vitality concomitant with a down-regulation of Cyclin D1 and up-regulation of p21 levels respect to cells treated with Cyclosporine A alone.	Cyclosporine	62-76	cyclin D1	Homo sapiens	186-195
23831333-3	2013	MDA-MB-231 cells cultured in the presence of DIOA exhibited an increase in cell volume, a decrease in intracellular Cl(-) concentration, and reduction in cell proliferation with the G0/G1 phase arrest, which was accompanied with down-regulation of cyclin D1 and cyclin E2, and up-regulation of p21.	((dihydroindenyl)oxy)alkanoic acid	45-49	cyclin D1	Homo sapiens	248-257
24042352-7	2013	The inverse correlation between the expression levels of RUNX3 and Akt in H2O2-treated cells was also associated with nuclear translocation of beta-catenin and upregulation of cyclin D1 expression, which induced cell proliferation.	Hydrogen Peroxide	74-78	cyclin D1	Homo sapiens	176-185
24042352-8	2013	H2O2 treatment also increased the binding of beta-catenin to the cyclin D1 promoter.	Hydrogen Peroxide	0-4	cyclin D1	Homo sapiens	65-74
24015932-6	2013	In clinical practice, oral administration of berberine also significantly reduced the familial adenomatous polyposis patients" polyp size along with the inhibition of cyclin D1 expression in polyp samples.	Berberine	45-54	cyclin D1	Homo sapiens	167-176
23525482-2	2013	An early resveratrol effect was the inhibition of AKT and mitogen-activated protein kinase signaling, accompanied by down regulation of cyclin D1 expression, abrogation of retinoblastoma protein hyperphosphorylation, and subsequent inhibition of cell cycle reentry and clonal expansion, as indicated by cyclin A2 repression.	Resveratrol	9-20	cyclin D1	Homo sapiens	136-145
23907019-8	2013	We found that puerarin can suppress estrogen-stimulated proliferation partly through down-regulating the transcription of cyclin D1 and cdc25A by promoting the recruitment of corepressors to estrogen receptor-alpha as well as limiting that of coactivators in ESCs.	puerarin	14-22	cyclin D1	Homo sapiens	122-131
24112473-14	2013	Cell cycle analysis showed that MK-801 induced G1 cell cycle arrest by down-regulating cyclin D1 and up-regulating p27.	Dizocilpine Maleate	32-38	cyclin D1	Homo sapiens	87-96
24100610-4	2013	Overexpression of let-7e by transfection of agomir could resensitize A2780/CP and reduce the expression of cisplatin-resistant-related proteins enhancer of zeste 2 (EZH2) and cyclin D1 (CCND1), whereas let-7e inhibitors increased resistance to cisplatin in parental A2780 cells.	Cisplatin	107-116	cyclin D1	Homo sapiens	175-184
23911876-10	2013	On the other hand, changes in expression of cyclin D1 (CCND1), insulin receptor substrate 1 (IRS1) and protein kinase C isoforms (PRKCZ,PRKCB and PRKCA) may be responsible for the induction of resistance to ATO.	Arsenic Trioxide	207-210	cyclin D1	Homo sapiens	44-53
24100610-4	2013	Overexpression of let-7e by transfection of agomir could resensitize A2780/CP and reduce the expression of cisplatin-resistant-related proteins enhancer of zeste 2 (EZH2) and cyclin D1 (CCND1), whereas let-7e inhibitors increased resistance to cisplatin in parental A2780 cells.	Cisplatin	107-116	cyclin D1	Homo sapiens	186-191
23924696-4	2013	In this paper, our data suggested that the Jagged-1/Notch3 signaling transduction pathway is involved in apelin-13-induced VSMC proliferation by promoting the expression of Cyclin D1.	vsmc	123-127	cyclin D1	Homo sapiens	173-182
24124611-6	2013	Specifically, treatment of NCI-H441 and SK-MES-1 cells with delphindin (5-60 microM) resulted in (i) cleavage of PARP protein, (ii) activation of caspase-3 and -9, (iii) downregulation of anti-apoptotic proteins (Bcl2, Bcl-xL and Mcl-1), (iv) upregulation of pro-apoptotic proteins (Bax and Bak), and (v) decreased expression of PCNA and cyclin D1.	delphindin	60-70	cyclin D1	Homo sapiens	338-347
23742826-6	2013	In addition, ATP increased the expression of the cyclins D1 and D3 and down-regulated the cell cycle inhibitory proteins p21Cip1 and p27Kip1.	Adenosine Triphosphate	13-16	cyclin D1	Homo sapiens	49-66
23912246-11	2013	CONCLUSIONS: Perifosine inhibits the growth of gastric cancer cells possibly through inhibition of the Akt/GSK3beta/C-MYC signaling pathway-mediated down-regulation of AEG-1 that subsequently down-regulated cyclin D1.	perifosine	13-23	cyclin D1	Homo sapiens	207-216
23939040-4	2013	Cell cycle arrest at G0/G1 was induced and cyclin D1 and cyclin A were downregulated upon piperine treatment.	piperine	90-98	cyclin D1	Homo sapiens	43-52
24156707-7	2013	RESULTS: Estrogenic effect of BPA was confirmed in the following checkpoints: mRNA expression of estrogen receptor alpha, expression of cyclin D1 and A2 proteins and CCNA2 gene, Bax and Bcl2 protein levels.	bisphenol A	30-33	cyclin D1	Homo sapiens	136-145
24634935-8	2013	RESULTS: Octreotide treatment increased SSTR2,SSTR5-induced apoptosis of SW480 colon cancer cells, promoted the plasma membrane accumulation of beta-catenin, inactivated T-cell factor-dependent transcription, and downregulated Wnt target genes cyclin D1 and c-Myc.	Octreotide	9-19	cyclin D1	Homo sapiens	244-253
23650147-11	2013	The resveratrol glucuronides also reduced cyclin D1 levels but at higher concentrations than in growth experiments and generally did not increase phosphorylated AMP-activated protein kinase.	resveratrol glucuronides	4-28	cyclin D1	Homo sapiens	42-51
24604959-10	2013	CONCLUSION: IHC may be a feasible tool for the demonstration of cyclin D1 expression on adequately processed trephine biopsy specimen in MM patients in a resource poor setting.	trephine	109-117	cyclin D1	Homo sapiens	64-73
23900299-6	2013	Triptolide treatment resulted in a significant decrease in mRNA expression levels in genes encoding Bcl-2, cyclin D1, p27 and survivin and an increase in those encoding Bax and p21 in THP-1 cells.	triptolide	0-10	cyclin D1	Homo sapiens	107-116
23896061-4	2013	HS-ASA down-regulated beta-catenin protein levels and reduced mRNA and protein expression of beta-catenin/TCF downstream target genes cyclinD1 and c-myc.	hs-asa	0-6	cyclin D1	Homo sapiens	134-142
23797319-6	2013	The results of present study showed that MK-2206-induced G1-phase arrest was associated with a marked decrease in the protein expression of cyclin D1 with concomitant induction of p21 and p27.	MK 2206	41-48	cyclin D1	Homo sapiens	140-149
23650147-12	2013	CONCLUSION: Resveratrol glucuronides inhibit cell growth by G1 arrest and cyclin D1 depletion, and our results strongly suggest a role for A3 adenosine receptors in this inhibition.	resveratrol glucuronides	12-36	cyclin D1	Homo sapiens	74-83
23672191-6	2013	The inhibition of Akt, using LY294002, abolished the accumulation and nuclear translocation of beta-catenin induced by AIMP1, leading to a decrease in c-myc and cyclin D1 expression, which decreased the proliferation of BMMSCs.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	cyclin D1	Homo sapiens	161-170
24065533-6	2013	The results of Western blot, RT-PCR and luciferase assays showed that transcriptional activity of the cyclin D1 promoter was suppressed by the bZIP domain of HBZ (HBZ-bZIP) through cyclic AMP response element (CRE) site.	Cyclic AMP	181-191	cyclin D1	Homo sapiens	102-111
23836497-0	2013	MiRNA-20 and mirna-106a regulate spermatogonial stem cell renewal at the post-transcriptional level via targeting STAT3 and Ccnd1.	mirna-20	0-8	cyclin D1	Homo sapiens	124-129
23836497-0	2013	MiRNA-20 and mirna-106a regulate spermatogonial stem cell renewal at the post-transcriptional level via targeting STAT3 and Ccnd1.	mirna-106a	13-23	cyclin D1	Homo sapiens	124-129
24086526-9	2013	We found that sorafenib inhibits Jak/Stat3 signaling and downregulates their target genes, including cyclin D1, cyclin D2 and Mcl-1, in a dose-dependent manner.	Sorafenib	14-23	cyclin D1	Homo sapiens	101-110
23974099-4	2013	We noticed that a synthetic inhibitor of CDK 4/6 (PD0332991) also induced cyclin D1-positive senescence.	palbociclib	50-59	cyclin D1	Homo sapiens	74-83
24041220-11	2013	The hexane extract showed highest toxicity against p53-deficient HL-60 cells (IC50 1.5 mg dry roots equivalent/ml medium) after 72 h and interestingly, inhibition of cell proliferation was preceded by the upregulation of the proto-oncogenes Cdc25A and cyclin D1 within 24 h. The hexane extract induced 18% apoptosis after 48 h of treatment.	Hexanes	4-10	cyclin D1	Homo sapiens	252-261
23827155-5	2013	cyclinD1, p21, p27(kip1), AKT, p-AKT, FOXO1 and p-FOXO1 expressions in the transfected Tca8113 were detected by western blot analysis.	tca8113	87-94	cyclin D1	Homo sapiens	0-8
23897809-8	2013	To test whether cyclin D1 promotes G1/S transition though enhancing NDR1/2 kinase activity, we performed flow cytometry analysis using cyclin D1 and cyclin D1 K112E Tet-On inducible cell lines.	tetramethylenedisulfotetramine	165-168	cyclin D1	Homo sapiens	16-25
23850521-3	2013	Activation of TLR3 by polyinosinic-polycytidylic acid [poly (I:C)] was shown to trigger the decline of cyclin D1/2 protein levels in pancreatic beta-cell lines, which could be reversed by the proteasome inhibitor MG132.	Poly I-C	22-53	cyclin D1	Homo sapiens	103-114
23850521-3	2013	Activation of TLR3 by polyinosinic-polycytidylic acid [poly (I:C)] was shown to trigger the decline of cyclin D1/2 protein levels in pancreatic beta-cell lines, which could be reversed by the proteasome inhibitor MG132.	Poly I-C	55-65	cyclin D1	Homo sapiens	103-114
23850521-3	2013	Activation of TLR3 by polyinosinic-polycytidylic acid [poly (I:C)] was shown to trigger the decline of cyclin D1/2 protein levels in pancreatic beta-cell lines, which could be reversed by the proteasome inhibitor MG132.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	213-218	cyclin D1	Homo sapiens	103-114
23861098-3	2013	The objective of this study was to examine the relationship between aluminum concentrations in the peripheral and central areas of breast tumors with the instability of three key genes in breast cancer, ERBB2, C-MYC, and CCND1 and aneuploidy of the chromosomes harboring these genes.	Aluminum	68-76	cyclin D1	Homo sapiens	221-226
23852369-2	2013	Hyperexpression of cyclin D1 is a universal marker of senescence along with hypertrophy, beta-Gal staining and loss of replicative/regenerative potential (RP), namely, the ability to restart proliferation when the cell cycle is released.	beta-D-galactose	89-97	cyclin D1	Homo sapiens	19-28
23852369-4	2013	Here we show that in p21- and p16-induced senescence, inhibitors of mitogen-activated/extracellular signal-regulated kinase (MEK) (U0126, PD184352 and siRNA) completely prevented cyclin D1 accumulation, making it undetectable.	U 0126	131-136	cyclin D1	Homo sapiens	179-188
23852369-4	2013	Here we show that in p21- and p16-induced senescence, inhibitors of mitogen-activated/extracellular signal-regulated kinase (MEK) (U0126, PD184352 and siRNA) completely prevented cyclin D1 accumulation, making it undetectable.	2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide	138-146	cyclin D1	Homo sapiens	179-188
23852369-6	2013	In such cells, U0126 by itself induced senescence that was remarkably cyclin D1 negative.	U 0126	15-20	cyclin D1	Homo sapiens	70-79
23852369-7	2013	In contrast, inhibition of cyclin-dependent kinase (CDK) 4/6 by PD0332991 caused cyclin D1-positive senescence in MEL10 cells.	palbociclib	64-73	cyclin D1	Homo sapiens	81-90
23852369-9	2013	We confirmed that the inhibitor of CDK4/6 caused cyclin D1 positive senescence in normal RPE cells, whereas U0126 prevented cyclin D1 expression.	U 0126	108-113	cyclin D1	Homo sapiens	124-133
23820419-11	2013	Western blot analysis showed that, in comparison with the untargeted vector Ad-TK, Ad-SSTR-RGD-TK/GCV more effectively reduced expression of proteins that regulate the cell cycle (Cyclin D1) and proliferation (PCNA, Proliferating Cell Nuclear Antigen), and it induced expression of the apoptotic protein BAX, in HuLM cells.	Ganciclovir	98-101	cyclin D1	Homo sapiens	180-189
23833299-9	2013	CONCLUSIONS: Copy number changes in CDKN2A, CCND1, and mutation/copy number changes in PTEN correlated with the duration of PFS in patients treated with dabrafenib.	dabrafenib	153-163	cyclin D1	Homo sapiens	44-49
23969186-0	2013	Antiproliferative and proapoptotic activity of sunitinib on endothelial and anaplastic thyroid cancer cells via inhibition of Akt and ERK1/2 phosphorylation and by down-regulation of cyclin-D1.	Sunitinib	47-56	cyclin D1	Homo sapiens	183-192
23969186-12	2013	CONCLUSIONS: Sunitinib is active in vitro and in vivo against activated endothelial and ATC cells via the inhibition of Akt and ERK1/2 phosphorylation and through the down-regulation of cyclin-D1.	Sunitinib	13-22	cyclin D1	Homo sapiens	186-195
23864650-4	2013	In addition, expression profiling of 17beta-estradiol-stimulated cyclin D1 small interfering RNA treated MCF7 cells shows cyclin D1 is required for estrogen-mediated gene expression in vitro.	17beta	37-43	cyclin D1	Homo sapiens	65-74
23804703-6	2013	The mechanism by which sulindac sulfide and the cGMP/PKG pathway inhibits colon tumor cell growth involves the transcriptional suppression of beta-catenin to inhibit Wnt/beta-catenin T-cell factor transcriptional activity, leading to downregulation of cyclin D1 and survivin.	sulindac sulfide	23-39	cyclin D1	Homo sapiens	252-261
23804703-6	2013	The mechanism by which sulindac sulfide and the cGMP/PKG pathway inhibits colon tumor cell growth involves the transcriptional suppression of beta-catenin to inhibit Wnt/beta-catenin T-cell factor transcriptional activity, leading to downregulation of cyclin D1 and survivin.	Cyclic GMP	48-52	cyclin D1	Homo sapiens	252-261
23864650-4	2013	In addition, expression profiling of 17beta-estradiol-stimulated cyclin D1 small interfering RNA treated MCF7 cells shows cyclin D1 is required for estrogen-mediated gene expression in vitro.	17beta	37-43	cyclin D1	Homo sapiens	122-131
23864650-4	2013	In addition, expression profiling of 17beta-estradiol-stimulated cyclin D1 small interfering RNA treated MCF7 cells shows cyclin D1 is required for estrogen-mediated gene expression in vitro.	Estradiol	44-53	cyclin D1	Homo sapiens	65-74
23864650-4	2013	In addition, expression profiling of 17beta-estradiol-stimulated cyclin D1 small interfering RNA treated MCF7 cells shows cyclin D1 is required for estrogen-mediated gene expression in vitro.	Estradiol	44-53	cyclin D1	Homo sapiens	122-131
23578093-5	2013	Cyclin D1 protein levels decreased significantly following doxorubicin treatment indicative of a G1/S arrest.	Doxorubicin	59-70	cyclin D1	Homo sapiens	0-9
23932824-6	2013	Furthermore, MAG-DPA treatments decreased NFkappaB activation leading to a reduction in Bcl-2, CyclinD1, c-myc, COX-2, MMP9 and VEGF expression levels in tumor tissue sections.	1-O-docosapentaenoylglycerol	13-20	cyclin D1	Homo sapiens	95-103
23899521-5	2013	SL-01 modulated the expressions of p-ATM, p53 and p21 and decrease of cyclin D1 in MCF-7 cells.	dodecyl-3-((1-(3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamoyl)pyrazine-2-carboxylate	0-5	cyclin D1	Homo sapiens	70-79
23941782-10	2013	Cd plus 5-FU decreased cyclin D1 and increased cyclin A1 expression.	Cadmium	0-2	cyclin D1	Homo sapiens	23-32
23941782-10	2013	Cd plus 5-FU decreased cyclin D1 and increased cyclin A1 expression.	Fluorouracil	8-12	cyclin D1	Homo sapiens	23-32
23698124-5	2013	Blocking class I HDAC activity with a highly selective inhibitor, MS-275, induced global histone H3 hyperacetylation, reduced RPTC proliferation, and diminished expression of cyclin D1 and proliferating cell nuclear antigen.	entinostat	66-72	cyclin D1	Homo sapiens	175-184
23732299-8	2013	Sorafenib and its metabolites, again with the exception of N"-hydroxymethylsorafenib N-oxide, impaired MEK/ERK signaling in MDA-MB-231 cells and modulated the expression of cyclin D1 and myeloid cell leukemia sequence-1, which regulate cell viability.	Sorafenib	0-9	cyclin D1	Homo sapiens	173-219
23470834-6	2013	Western blot and real-time PCR analyses further confirmed that melatonin"s inhibitory effect was possibly because of downregulation of cyclin D1 and CDK4, related to the G(1) phase, and of cyclin B1 and CDK1, related to the G(2)/M phase.	Melatonin	63-72	cyclin D1	Homo sapiens	135-144
23470834-8	2013	These findings provide evidence that melatonin may significantly inhibit human osteosarcoma cell proliferation in a dose-dependent and time-dependent manner and this inhibition involves the downregulation of cyclin D1, CDK4, cyclin B1 and CDK1.	Melatonin	37-46	cyclin D1	Homo sapiens	208-217
23688861-5	2013	Brucine-mediated cell cycle arrest in G1 phase was associated with a marked increase of protein levels of CCND1 and decrease in CCNB1, cyclin E and CDC2.	brucine	0-7	cyclin D1	Homo sapiens	106-111
23686769-7	2013	Vorinostat also reduced cyclin D1 and cyclin E expression, but increased p27 levels in post- versus pretreatment human lung cancer biopsies.	Vorinostat	0-10	cyclin D1	Homo sapiens	24-33
24036549-3	2013	Recently we demonstrated that hyper-induction of cyclin D1 during geroconversion was mostly dependent on MEK, whereas rapamycin only partially inhibited cyclin D1 accumulation.	Sirolimus	118-127	cyclin D1	Homo sapiens	153-162
23766363-9	2013	The limonoid-treated xenografts exhibited significant downregulation in the expression of proteins involved in tumor cell survival (Bcl-2, Bcl-xL, c-IAP-1, survivin, and Mcl-1), proliferation (c-Myc and cyclin D1), invasion (MMP-9, ICAM-1), metastasis (CXCR4), and angiogenesis (VEGF).	Limonins	4-12	cyclin D1	Homo sapiens	203-212
23947899-3	2013	METHODS: Cyclin D1 immunohistochemical analysis (IHC) was used to evaluate 201 fixed, paraffin-embedded endometrial samples which included simple hyperplasia (n = 27), atypical complex hyperplasia (ACH) (n = 41), endometrioid carcinoma (n = 103), endometrial serous carcinoma (ESC) (n = 21) and clear cell carcinoma (CCC) (n = 9).	Paraffin	86-94	cyclin D1	Homo sapiens	9-18
23186333-5	2013	Interestingly, the increased reactive oxygen species (ROS) by null mutation of Prx I greatly promoted K-ras(G12D)-driven lung tumorigenesis in number and size, which appeared to require the activation of the ROS-dependent extracellular signal-regulated kinase (ERK)/cyclin D1 pathway.	Reactive Oxygen Species	54-57	cyclin D1	Homo sapiens	266-275
23186333-5	2013	Interestingly, the increased reactive oxygen species (ROS) by null mutation of Prx I greatly promoted K-ras(G12D)-driven lung tumorigenesis in number and size, which appeared to require the activation of the ROS-dependent extracellular signal-regulated kinase (ERK)/cyclin D1 pathway.	Reactive Oxygen Species	208-211	cyclin D1	Homo sapiens	266-275
23951092-6	2013	A specific PPARalpha antagonist, GW6471, induced both apoptosis and cell cycle arrest at G0/G1 in VHL(+) and VHL(-) RCC cell lines (786-O and Caki-1) associated with attenuation of the cell cycle regulatory proteins c-Myc, Cyclin D1, and CDK4; this data was confirmed as specific to PPARalpha antagonism by siRNA methods.	GW 6471	33-39	cyclin D1	Homo sapiens	223-232
23914993-8	2013	The decreased expression of Wnt/beta-Catenin targeting genes, such as cyclin D1, C-myc and survivin, and the inhibition of the activity of the transcription factor (T-cell factor 4, TCF-4) were observed in GL-treated breast cancer cells.	guggulu extract	206-208	cyclin D1	Homo sapiens	70-79
23839043-7	2013	Treatment of breast cancer cells with inhibitors of cyclin D1 and CDK4/6 (Flavopiridol/PD0332991), currently in clinical trials, mimicked the effects observed with siRNA treatment.	alvocidib	74-86	cyclin D1	Homo sapiens	52-61
23839043-7	2013	Treatment of breast cancer cells with inhibitors of cyclin D1 and CDK4/6 (Flavopiridol/PD0332991), currently in clinical trials, mimicked the effects observed with siRNA treatment.	palbociclib	87-96	cyclin D1	Homo sapiens	52-61
23723126-0	2013	Cyclin d1 downregulation contributes to anticancer effect of isorhapontigenin on human bladder cancer cells.	isorhapontigenin	61-77	cyclin D1	Homo sapiens	0-9
23723126-3	2013	We found that isorhapontigenin showed a significant inhibitory effect on human bladder cancer cell growth and was accompanied with related cell cycle G(0)-G(1) arrest as well as downregulation of cyclin D1 expression at the transcriptional level in UMUC3 and RT112 cells.	isorhapontigenin	14-30	cyclin D1	Homo sapiens	196-205
23723126-4	2013	Further studies identified that isorhapontigenin downregulated cyclin D1 gene transcription via inhibition of specific protein 1 (SP1) transactivation.	isorhapontigenin	32-48	cyclin D1	Homo sapiens	63-72
23723126-5	2013	Moreover, ectopic expression of GFP-cyclin D1 rendered UMUC3 cells resistant to induction of cell-cycle G(0)-G(1) arrest and inhibition of cancer cell anchorage-independent growth by isorhapontigenin treatment.	isorhapontigenin	183-199	cyclin D1	Homo sapiens	36-45
23723126-6	2013	Together, our studies show that isorhapontigenin is an active compound that mediates Gnetum Cleistostachyum"s induction of cell-cycle G(0)-G(1) arrest and inhibition of cancer cell anchorage-independent growth through downregulating SP1/cyclin D1 axis in bladder cancer cells.	isorhapontigenin	32-48	cyclin D1	Homo sapiens	237-246
23732836-8	2013	Cyclin D1, CDK4 and Bcl-2 protein expression was inhibited by TOFA, while caspase-3 was cleaved and activated.	5-(tetradecyloxy)-2-furancarboxylic acid	62-66	cyclin D1	Homo sapiens	0-9
23708383-5	2013	Evodiamine-induced G0/G1 arrest and apoptosis were associated with a decrease in Bcl-2, cyclin D1 and cyclin-dependent kinase 6 (CDK6) expression and an increase in Bax and p27Kip1 expression.	evodiamine	0-10	cyclin D1	Homo sapiens	88-97
23936501-7	2013	TCN inhibits the phosphorylation and degradation of IkappaBalpha and blocks the nuclear translocation of p65, and thus inhibits the expression of NF-kappaB target genes XIAP, cyclin D1, and Bcl-xL.	trichothecin	0-3	cyclin D1	Homo sapiens	175-184
23481022-8	2013	Among the analogs tested, SC144 exhibited the highest cytotoxicity in a panel of colon cancer cell lines in a p53-independent manner, accompanied by cell cycle arrest in G0/G1 with downregulation of Cyclin D1 levels, and apoptosis induction with upregulation of cell surface-bound Fas/CD95.	SC 144	26-31	cyclin D1	Homo sapiens	199-208
23895220-13	2013	The RAF/MEK/ERK and STAT3 pathways were blocked and cyclin D1 expression was down regulated significantly in both cell lines by sorafenib; whereas, the kinase pathways were hardly affected by 5-FU, and cyclin D1 expression was up regulated.	Sorafenib	128-137	cyclin D1	Homo sapiens	52-61
23685341-3	2013	Exposure to 2-OHE2, 4-OHE2 or E2 resulted in a significant increase in the protein abundance of cyclin D1 and c-myc.	2-hydroxyestradiol	12-18	cyclin D1	Homo sapiens	96-105
23685341-3	2013	Exposure to 2-OHE2, 4-OHE2 or E2 resulted in a significant increase in the protein abundance of cyclin D1 and c-myc.	4-ohe2	20-26	cyclin D1	Homo sapiens	96-105
23866847-9	2013	MiR-329 significantly decreased the phosphorylation levels of intracellular kinases Akt and expression of cyclin D1, but the expression of p21 was upregulated, cell growth was suppressed by inhibiting E2F1-mediated Akt pathway.	mir-329	0-7	cyclin D1	Homo sapiens	106-115
23874806-9	2013	The cell cycle regulator cyclin D1 (CCND1) showed significant up-regulation following treatment with TAM.	Tamoxifen	101-104	cyclin D1	Homo sapiens	25-34
23874806-9	2013	The cell cycle regulator cyclin D1 (CCND1) showed significant up-regulation following treatment with TAM.	Tamoxifen	101-104	cyclin D1	Homo sapiens	36-41
23552471-9	2013	Further experiments showed that fengycin could trigger apoptosis in 95D cells and cause cell-cycle arrest at the G0/G1 stage by downregulating cyclin D1 and cyclin-dependent kinase 4 (CDK4).	fengycin	32-40	cyclin D1	Homo sapiens	143-152
23422327-8	2013	RT-PCR showed the highest increase of cyclin D1 expression for HPdLF and HOB when applied to 5% of SMS, and HOB showed a doubling of COL-I gene expression.	sms	99-102	cyclin D1	Homo sapiens	38-47
23773853-8	2013	Our results demonstrate that Pho-s induces a cell cycle arrest in the G1 phase through an inhibition of cyclin D1 and stimulates p53.	phosphorylethanolamine	29-34	cyclin D1	Homo sapiens	104-113
23792647-9	2013	CINK4 induced G 1 arrest by downregulating the p16/cyclin D1/Rb pathway, resulting in apoptotic induction via increased expression of cleaved caspase3, cleaved PARP and Bax.	CINK4	0-5	cyclin D1	Homo sapiens	51-60
23792647-10	2013	Combined CINK4 and paclitaxel produced synergistic anti-proliferative activity and increased apoptosis through reduced cyclin D1 and Bcl-2 in KRAS mutation-positive cancer cells.	CINK4	9-14	cyclin D1	Homo sapiens	119-128
23807222-6	2013	Salinomycin inhibited signal transducer and activator of transcription 3 (Stat3) activity and thus decreased expression of Stat3-target genes, including cyclin D1, Skp2, and survivin.	salinomycin	0-11	cyclin D1	Homo sapiens	153-162
23792647-10	2013	Combined CINK4 and paclitaxel produced synergistic anti-proliferative activity and increased apoptosis through reduced cyclin D1 and Bcl-2 in KRAS mutation-positive cancer cells.	Paclitaxel	19-29	cyclin D1	Homo sapiens	119-128
23474115-6	2013	Inhibition of phospho-STAT3 was found in cells treated with sorafenib or sorafenib plus radiation and subsequently reduced the expression levels of STAT3-related proteins, Mcl-1, cyclin D1, and survivin.	Sorafenib	60-69	cyclin D1	Homo sapiens	179-188
23474115-6	2013	Inhibition of phospho-STAT3 was found in cells treated with sorafenib or sorafenib plus radiation and subsequently reduced the expression levels of STAT3-related proteins, Mcl-1, cyclin D1, and survivin.	Sorafenib	73-82	cyclin D1	Homo sapiens	179-188
23708609-9	2013	Both PBIT and PBI-Se induced dose-dependent apoptosis in CaCo2 cells and caused a significant decrease in the cell cycle proteins cyclin D1 (70%, p&lt;0.0001) and iNOS (99%, p&lt;0.0001).	S,S'-1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea	5-9	cyclin D1	Homo sapiens	130-139
23708609-9	2013	Both PBIT and PBI-Se induced dose-dependent apoptosis in CaCo2 cells and caused a significant decrease in the cell cycle proteins cyclin D1 (70%, p&lt;0.0001) and iNOS (99%, p&lt;0.0001).	pbi-se	14-20	cyclin D1	Homo sapiens	130-139
23026511-4	2013	Using primary cultured human keratinocytes, we further demonstrated that 1,25(OH)2-dihydroxyvitamin D3 (1,25(OH)2D3) suppresses cyclin D1 and Gli1 which are regulated by beta-catenin/TCF signaling and have a critical role in epidermal carcinogenesis.	1,25(oh)2-dihydroxyvitamin d3	73-102	cyclin D1	Homo sapiens	128-137
23026511-4	2013	Using primary cultured human keratinocytes, we further demonstrated that 1,25(OH)2-dihydroxyvitamin D3 (1,25(OH)2D3) suppresses cyclin D1 and Gli1 which are regulated by beta-catenin/TCF signaling and have a critical role in epidermal carcinogenesis.	1,25(oh)2d3	104-115	cyclin D1	Homo sapiens	128-137
24022933-6	2013	L-OHP induced S cell cycle arrest in HepG2 cell; down-regulated the levels of CDK4, cyclinD1 and up-regulated the levels of p21, p53.	Oxaliplatin	0-5	cyclin D1	Homo sapiens	84-92
23690508-4	2013	The high-glucose condition led to increased expression of cyclin D1, de-phosphorylation of p38, and increased phosphorylation of ERK in MDA-MB-231 cells but not in MCF-7 cells.	Glucose	9-16	cyclin D1	Homo sapiens	58-67
23807222-12	2013	Taken together, our data indicate that salinomycin induces cell cycle arrest and apoptosis via downregulation or inactivation of cell cycle-associated oncogenes, such as Stat3, cyclin D1, and Skp2, regardless of multidrug resistance.	salinomycin	39-50	cyclin D1	Homo sapiens	177-186
23688195-2	2013	Here, we utilized 6 for preparation of labeled oligodeoxynucleotide (ODN) probes based on MS2 and cyclin D1 (a known breast cancer mRNA marker) sequences.	Oligodeoxyribonucleotides	47-67	cyclin D1	Homo sapiens	98-107
23688195-2	2013	Here, we utilized 6 for preparation of labeled oligodeoxynucleotide (ODN) probes based on MS2 and cyclin D1 (a known breast cancer mRNA marker) sequences.	Oligodeoxyribonucleotides	69-72	cyclin D1	Homo sapiens	98-107
23688195-4	2013	On the basis of this finding, we developed the ds-NIF (nucleoside with intrinsic fluorescence)-probe methodology for detection of cyclin D1 mRNA, by which the fluorescent probe is released upon recognition of target mRNA by the relatively dark NIF-duplex-probe.	Nucleosides	55-65	cyclin D1	Homo sapiens	130-139
23653462-5	2013	We found that NVP-BEZ235 is twice as potent as everolimus in reducing cell viability and activating apoptosis in human BC tissues that display sensitivity to mTOR inhibitors, but is not effective in everolimus-resistant BC tissues and cell lines that bypass cyclin D1 downregulation and escape G0/G1 blockade.	dactolisib	18-24	cyclin D1	Homo sapiens	258-267
23688195-5	2013	Indeed, we successfully detected, a ss-deoxynucleic acid (DNA) variant of cyclin D1 mRNA using a dark NIF-labeled duplex-probe, and monitoring the recognition process by fluorescence spectroscopy and gel electrophoresis.	ss-deoxynucleic acid	36-56	cyclin D1	Homo sapiens	74-83
23764045-8	2013	Targeting these activated pro-proliferative genes by combined approaches of HDAC-inhibitors plus fenretinide, which inhibits cyclinD1, exhibit strong synergistic effects on induction of apoptosis.	Fenretinide	97-108	cyclin D1	Homo sapiens	125-133
23788190-4	2013	After treatment with fraxetin, the expression of ERalpha in MCF-7 cell was decreased, and estrogen genomic signaling pathway was inhibited by down-regulating the expression of cyclin D1 and Bcl-2 proteins.	fraxetin	21-29	cyclin D1	Homo sapiens	176-185
23806108-13	2013	Knockdown of cyclin D1 expression significantly increased cisplatin-induced G1 arrest and apoptosis.	Cisplatin	58-67	cyclin D1	Homo sapiens	13-22
23806108-14	2013	CONCLUSIONS: Collectively, our results indicated that cisplatin treatment leads to Let-7b suppression, which in turn up-regulates cyclin D1 expression.	Cisplatin	54-63	cyclin D1	Homo sapiens	130-139
23497867-2	2013	The results show that regarding cell cycle-related proteins, three types of polysaccharides significantly enhance the expression of p27(Kip) in HepG2 and Bel-7404 cells, while suppressing the activity of cyclin D1/CDK4 and/or cyclin E/CDK2.	Polysaccharides	76-91	cyclin D1	Homo sapiens	204-213
23554130-6	2013	Limonene intervention resulted in a 22% reduction in cyclin D1 expression (P = 0.002) in tumor tissue but minimal changes in tissue Ki67 and cleaved caspase-3 expression.	Limonene	0-8	cyclin D1	Homo sapiens	53-62
23562784-0	2013	Regulation of cellular Cyclin D1 gene by arsenic is mediated through miR-2909.	Arsenic	41-48	cyclin D1	Homo sapiens	23-32
23755153-6	2014	Tamoxifen treatment significantly altered the hormone receptor expression levels of the tumor, while additionally upregulating Bcl-2 and Cyclin D1.	Tamoxifen	0-9	cyclin D1	Homo sapiens	137-146
23438367-6	2013	Trametinib induced p15 and p27 expression and reduced cyclin D1 levels in HT-29 cells.	trametinib	0-10	cyclin D1	Homo sapiens	54-63
23438367-7	2013	Fenofibrate also dephosphorlated ERK1/2 and reduced cyclin D1 levels in HT-29 cells.	Fenofibrate	0-11	cyclin D1	Homo sapiens	52-61
23745024-3	2013	Real time polymerase chain reaction and Western blotting were used to observe expression changes in p21, p53, Bax, Bcl-2, CDK2, and CyclinD1 in gastric cancer cells exposed to TSA.	trichostatin A	176-179	cyclin D1	Homo sapiens	132-140
23745024-7	2013	p21, p53 and Bax gene expression levels in AGS cells were increased with TSA treatment duration; Bcl-2, CDK2, and CyclinD1 gene expression levels were decreased with TSA treatment duration.	trichostatin A	166-169	cyclin D1	Homo sapiens	114-122
23500889-3	2013	Doxycycline (Dox)-induced expression of cPLA2alpha led to an increase in pAKT, pGSK3beta and cyclin D1 levels in LNCaP cells that possess a PTEN frame-shift mutation.	Doxycycline	0-11	cyclin D1	Homo sapiens	93-102
23500889-3	2013	Doxycycline (Dox)-induced expression of cPLA2alpha led to an increase in pAKT, pGSK3beta and cyclin D1 levels in LNCaP cells that possess a PTEN frame-shift mutation.	Doxycycline	0-3	cyclin D1	Homo sapiens	93-102
23554130-9	2013	We conclude that limonene distributed extensively to human breast tissue and reduced breast tumor cyclin D1 expression that may lead to cell-cycle arrest and reduced cell proliferation.	Limonene	17-25	cyclin D1	Homo sapiens	98-107
22959059-7	2013	EGCG was found to inhibit proliferation in Ishikawa as well as in primary endometrial adenocarcinoma cells and effectively down-regulated the expression of proliferation markers, i.e., estrogen receptor alpha, progesterone receptor, proliferating cell nuclear antigen and cyclin D1.	epigallocatechin gallate	0-4	cyclin D1	Homo sapiens	272-281
23602914-7	2013	Exposure of PA to HCT116 and SW480 cells activated p21 expression and suppressed the expressions of cyclin D1 and cyclin-dependent kinase 4 (CDK4) in a dose-dependent manner.	patchouli alcohol	12-14	cyclin D1	Homo sapiens	100-109
23563707-6	2013	The mRNA and protein levels of cyclin D1, CDK4, CDK6, (p)Rb and P16 consistently demonstrated a reverse trend with the levels in the chondrocytes treated with nocodazole.	Nocodazole	159-169	cyclin D1	Homo sapiens	31-40
23515614-4	2013	A low cyclin D1 expression predicted significantly better overall survival (OS; P = 0.001), disease-free survival (P = 0.005), locoregional recurrence-free survival (P = 0.003), and distant metastasis-free survival (DMFS; P = 0.002) compared with high cyclin D1 expression.	dmfs	216-220	cyclin D1	Homo sapiens	6-15
24024333-3	2013	Immunocytochemistry, Reverse transcription-polymerase chain reaction and western blotting were used to analyze the expression of MAPK1 (mitogen-activated protein kinases 1) and cyclin D1 in response to siRNA (small interfering RNA) transfection and taxol treatment.	Paclitaxel	249-254	cyclin D1	Homo sapiens	177-186
23515614-6	2013	However, patients with nodal stage cN2 whose tumors had high cyclin D1 expression treated with TPF had significantly greater OS (P = 0.025) and DMFS (P = 0.025) when compared with high cyclin D1 cN2 patients treated with surgery upfront.	TPF	95-98	cyclin D1	Homo sapiens	61-70
23515614-8	2013	This study indicates that cN2 OSCC patients with high cyclin D1 expression can benefit from the addition of TPF induction chemotherapy to standard treatment.	TPF	108-111	cyclin D1	Homo sapiens	54-63
23567149-8	2013	d-Ser efficacy was demonstrated in monolayer and three-dimensional cultures, and its antiproliferative action was associated with the inhibition of several leptin-induced pathways, including JAK/STAT3, MAPK/ERK1/2 and PI3K/AKT, cyclin D1, and E-cadherin.	D-serine	0-5	cyclin D1	Homo sapiens	228-237
23803204-9	2013	CONCLUSIONS: Celecoxib enhances the chemosensitivity of KB/VCR cells by down-regulating P-gp expression, which is partially mediated by modification of cyclin D1 and p21(WAF1/CIP1) to result in cell cycle arrest.	Celecoxib	13-22	cyclin D1	Homo sapiens	152-161
23525646-10	2013	In the HaCaT epithelial cells, arecoline downregulated expression of the G1/S phase regulatory proteins cyclin D1, CDK4, CDK2, E2F1 as determined by reverse transcription-PCR analysis and western blotting.	Arecoline	31-40	cyclin D1	Homo sapiens	104-113
23833659-11	2013	In addition, the proteins caspase-3 and Bax in cells treated with flavopiridol were upregulated, while cyclin D1 and Bcl-2 were downregulated.	alvocidib	66-78	cyclin D1	Homo sapiens	103-112
23833659-12	2013	In conclusion, flavopiridol may enhance the radiosensitivity of Eca109 cells and the radiosensitizing effect of flavopiridol may be mediated by decreasing the levels of the cyclin D1 protein, thus increasing the percentage of cells at G2/M phase.	alvocidib	112-124	cyclin D1	Homo sapiens	173-182
23545701-6	2013	NS-398 inhibited the NF-kappaB p65 protein levels and the expression of various NF-kappaB target genes, including cyclin D1, c-Myc, survivin and Bcl-2.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	cyclin D1	Homo sapiens	114-123
22290509-6	2013	The decreased cell viability observed in SkBr3 cells when curcumin was combined with TSA led to a G0/G1 cell cycle arrest and increased p21 and p27, and decreased Cyclin D1 protein expression.	Curcumin	58-66	cyclin D1	Homo sapiens	163-172
22290509-6	2013	The decreased cell viability observed in SkBr3 cells when curcumin was combined with TSA led to a G0/G1 cell cycle arrest and increased p21 and p27, and decreased Cyclin D1 protein expression.	trichostatin A	85-88	cyclin D1	Homo sapiens	163-172
23667504-10	2013	Moreover, (S)-11 and (R)-9 inhibited DNA synthesis by blocking the androgen-induced increase in cyclin D1 protein levels.	(s)-11	10-16	cyclin D1	Homo sapiens	96-105
23318226-0	2013	ATP stimulates PGE(2)/cyclin D1-dependent VSMCs proliferation via STAT3 activation: role of PKCs-dependent NADPH oxidase/ROS generation.	Adenosine Triphosphate	0-3	cyclin D1	Homo sapiens	22-31
23125009-8	2013	The CCND1 AA genotype variant was associated with an increased risk in individuals who were &amp;lt;40 years old (OR 1.45, 95% CI 1.02-2.08, p=0.04).	Adenosine Monophosphate	93-96	cyclin D1	Homo sapiens	4-9
23598417-6	2013	In addition, miR-590-5P expression suppressed the expression of Wnt5a, cMyc and cyclin D1, and increased the phosphorylation of beta-catenin and expression of Caspase 3, which may contribute to the inhibitory effect of miR-590-5P on cell growth.	590-5p	17-23	cyclin D1	Homo sapiens	80-89
23318226-9	2013	We also demonstrated that ATPgammaS induced cyclin D1 expression via a PGE2-dependent pathway.	Dinoprostone	71-75	cyclin D1	Homo sapiens	44-53
23345014-0	2013	Adenosine induces cell cycle arrest and apoptosis via cyclinD1/Cdk4 and Bcl-2/Bax pathways in human ovarian cancer cell line OVCAR-3.	Adenosine	0-9	cyclin D1	Homo sapiens	54-62
22773548-9	2013	Cell line studies showed that metformin inhibits hepatocyte proliferation and induces cell cycle arrest at G0/G1 phase via AMP-activated protein kinase and its upstream kinase LKB1 to upregulate p21/Cip1 and p27/Kip1 and downregulate cyclin D1 in a dose-dependent manner, but independent of p53.	Metformin	30-39	cyclin D1	Homo sapiens	234-243
23020673-4	2013	Deferasirox induced apoptosis mediated through caspase-3 activation and decreased cyclin D1 protein levels resulting from increased proteasomal degradation.	Deferasirox	0-11	cyclin D1	Homo sapiens	82-91
23020673-7	2013	The present data indicate that deferasirox, by down-regulating cyclin D1 and inhibiting its related signals, may constitute a promising adjuvant therapeutic molecule in the strategy for MCL treatment.	Deferasirox	31-42	cyclin D1	Homo sapiens	63-72
23436065-9	2013	The combination of vitamin A and vitamin D markedly enhanced the expression of Bax and reduced the expression of Cyclin D1 by real time-PCR and western blot assay.	Vitamin A	19-28	cyclin D1	Homo sapiens	113-122
23436065-9	2013	The combination of vitamin A and vitamin D markedly enhanced the expression of Bax and reduced the expression of Cyclin D1 by real time-PCR and western blot assay.	Vitamin D	33-42	cyclin D1	Homo sapiens	113-122
23543365-8	2013	For cells harboring the BRAFV600E, gossypin inhibited cell proliferation through abrogation of the MEK-ERK-cyclin D1 pathway and in cells with BRAF wild-type allele, through attenuation of the retinoblastoma-cyclin D1 pathway.	gossypin	35-43	cyclin D1	Homo sapiens	107-116
23543365-8	2013	For cells harboring the BRAFV600E, gossypin inhibited cell proliferation through abrogation of the MEK-ERK-cyclin D1 pathway and in cells with BRAF wild-type allele, through attenuation of the retinoblastoma-cyclin D1 pathway.	gossypin	35-43	cyclin D1	Homo sapiens	208-217
23599805-4	2013	Cyclopamine induced a robust G1 cell cycle arrest and elicited notable effects on the expression of cyclin D1 through modulation of the MAPK/ERK signaling pathway.	cyclopamine	0-11	cyclin D1	Homo sapiens	100-109
23345014-7	2013	Adenosine induced cell cycle arrest in G0/G1 phase via Cdk4/cyclinD1-mediated pathway.	Adenosine	0-9	cyclin D1	Homo sapiens	60-68
23345014-10	2013	The results of this study suggest that extracellular adenosine induced G1 cell cycle arrest and apoptosis in ovarian cancer cells via cyclinD1/ Cdk4 and Bcl-2/Bax pathways and caspase-3 activation.	Adenosine	53-62	cyclin D1	Homo sapiens	134-142
23643008-0	2013	[Expressions of p-c-jun and cyclinD1 between vascular smooth muscle cells and endothelial cells exposured to cigarette smoke extract].	cigarette smoke	109-124	cyclin D1	Homo sapiens	28-36
23985251-9	2013	cyclin D1 and Bcl-2 protein expression was up-regulated while p21 was down-regulated by rhAPRIL stimulation.	rhapril	88-95	cyclin D1	Homo sapiens	0-9
23370007-9	2013	APE1 redox activity also facilitated the Cyclin D1 expression and G1-to-S progression following Pb exposure.	Lead	96-98	cyclin D1	Homo sapiens	41-50
23180436-5	2013	Sunitinib induced G1 phase arrest associated with decreased cyclin D1, cyclin D3, and cyclin-dependent kinase (Cdk)2 and increased p27(Kip1), pRb1, and p130/Rb2 expression and phosphorylated activation of protein kinase C alpha and beta (PKCalpha/beta).	Sunitinib	0-9	cyclin D1	Homo sapiens	60-69
23043610-10	2013	Transfection of PC3 cells with p21 siRNA or a p21 mutant plasmid on the cyclin D1/ cycline-dependent kinase 4 binding site abolished the effects of MH on cell growth, cell viability and related protein expression.	4-O-methylhonokiol	148-150	cyclin D1	Homo sapiens	72-81
22763757-1	2013	PURPOSE: Gamma-glutamyl hydrolase (GGH), cyclin D1 (CCND1) and thymidylate synthase (TS) genes encode enzymes that are involved in methotrexate (MTX) action.	Methotrexate	131-143	cyclin D1	Homo sapiens	41-50
22763757-1	2013	PURPOSE: Gamma-glutamyl hydrolase (GGH), cyclin D1 (CCND1) and thymidylate synthase (TS) genes encode enzymes that are involved in methotrexate (MTX) action.	Methotrexate	131-143	cyclin D1	Homo sapiens	52-57
22763757-1	2013	PURPOSE: Gamma-glutamyl hydrolase (GGH), cyclin D1 (CCND1) and thymidylate synthase (TS) genes encode enzymes that are involved in methotrexate (MTX) action.	Methotrexate	145-148	cyclin D1	Homo sapiens	41-50
22763757-1	2013	PURPOSE: Gamma-glutamyl hydrolase (GGH), cyclin D1 (CCND1) and thymidylate synthase (TS) genes encode enzymes that are involved in methotrexate (MTX) action.	Methotrexate	145-148	cyclin D1	Homo sapiens	52-57
23266503-8	2013	In addition, we observed that baicalein induces G1 cell cycle arrest by decreasing cyclin D1 and cyclin-dependent kinase 4 (CDK4).	baicalein	30-39	cyclin D1	Homo sapiens	83-92
23079745-9	2013	Bioinformatics analysis of target sites and ectopic expression in HCC cells showed that miR-125a-5p and miR-125b suppressed SIRT7 and cyclin D1 expression and induced p21(WAF1/Cip1) -dependent G1 cell cycle arrest.	125a	92-96	cyclin D1	Homo sapiens	134-143
23079745-9	2013	Bioinformatics analysis of target sites and ectopic expression in HCC cells showed that miR-125a-5p and miR-125b suppressed SIRT7 and cyclin D1 expression and induced p21(WAF1/Cip1) -dependent G1 cell cycle arrest.	125b	108-112	cyclin D1	Homo sapiens	134-143
23270726-3	2013	The results indicated that enhanced cyclin D1 expression increased the activation of volume-activated chloride currents and promoted the expression of ClC-3 chloride channel proteins.	Chlorides	102-110	cyclin D1	Homo sapiens	36-45
23270726-7	2013	The CDK4/6 inhibitor fascaplysin chloride hydrate (highly selective for CDK4/cyclin D1 with IC(50) = 0.35 muM and less selective for CDK6/D1 with IC(50) = 3.4 muM) activated a chloride current in low concentration, but did not show significantly facilitative effects on the current in high concentration.	fascaplysin chloride hydrate	21-49	cyclin D1	Homo sapiens	77-86
23270726-7	2013	The CDK4/6 inhibitor fascaplysin chloride hydrate (highly selective for CDK4/cyclin D1 with IC(50) = 0.35 muM and less selective for CDK6/D1 with IC(50) = 3.4 muM) activated a chloride current in low concentration, but did not show significantly facilitative effects on the current in high concentration.	Chlorides	33-41	cyclin D1	Homo sapiens	77-86
23229592-10	2013	Metformin inhibited the growth of three ESCC cell lines, and this inhibition may have involved reductions in cyclin D1, Cdk4 and Cdk6.	Metformin	0-9	cyclin D1	Homo sapiens	109-118
23013422-3	2013	We observed that TSA increased the expression of proliferating cell nuclear antigen and cyclin D1 in hDPSCs at a certain concentration and the activation of JNK/c-Jun pathway was essential for TSA-dependent hDPSC proliferation.	trichostatin A	17-20	cyclin D1	Homo sapiens	88-97
23129580-9	2013	Interestingly, etoposide treatment also reduced TCF/LEF activity, beta-catenin and cyclin D1 levels commensurate with induction of DNA damage and apoptosis.	Etoposide	15-24	cyclin D1	Homo sapiens	83-92
23233089-4	2013	Furthermore, downregulation             of gamma-catenin by siRNA inhibited the proliferation and colony formation of CML             cells and the expression of the c-Myc and cyclin D1 genes; downregulation of gamma-catenin             also potentiated the effects of imatinib (inhibiting CML cell proliferation and             inducing apoptosis) and suppressed the anti-apoptotic genes Bcl-xL and survivin.	Imatinib Mesylate	269-277	cyclin D1	Homo sapiens	176-185
23275086-11	2013	Moreover, overexpression of PTEN could induce ASMCs arrested in the G0/G1 phase through the downregulation of Cyclin D1 and upregulation of p21 expressions.	asmcs	46-51	cyclin D1	Homo sapiens	110-119
23318178-0	2013	Sulfuretin-induced miR-30C selectively downregulates cyclin D1 and D2 and triggers cell death in human cancer cell lines.	sulfuretin	0-10	cyclin D1	Homo sapiens	53-62
22086611-8	2013	In contrast, lapatinib produced an accumulation of cells in the G(1) phase mediated through cyclin D1, but only in lapatinib-sensitive cells.	Lapatinib	13-22	cyclin D1	Homo sapiens	92-101
23074173-9	2013	We demonstrated that deferasirox increased expression of the metastasis suppressor protein N-myc downstream-regulated gene 1 and upregulated the cyclin-dependent kinase inhibitor p21(CIP1/WAF1) while decreasing cyclin D1 levels.	Deferasirox	21-32	cyclin D1	Homo sapiens	211-220
23441447-7	2013	Twenty-four hours of treatment with GA (0.5 micromol/L) following transfection with PKM2 siRNA-1 inhibited the vitality of the PC3 cells by 68%, increased their apoptosis, and significantly down-regulated the mRNA and protein levels of c-myc (50% and 35%) and cyclin D1 (60% and 20%) (P &lt; 0.05).	gambogic acid	36-38	cyclin D1	Homo sapiens	260-269
23144322-4	2013	The results show that hypoxia (3% O(2), 48 h) induced proliferation of human PASMCs, accompanied with a significant decrease in Wnt5a gene expression, increase in beta-catenin and Cyclin D1 expression, as well as beta-catenin nuclear translocation.	pasmcs	77-83	cyclin D1	Homo sapiens	180-189
23144322-7	2013	Knocking down beta-catenin or Cyclin D1 gene expression inhibited hypoxia-induced human PASMC proliferation, whereas overexpression of beta-catenin increased hypoxia-induced human PASMC proliferation and counteracted the inhibitory effect of Wnt5a.	pasmc	88-93	cyclin D1	Homo sapiens	30-39
23144322-8	2013	These results suggest that Wnt5a has an antiproliferative effect on hypoxia-induced human PASMC proliferation by downregulation of beta-catenin and its target gene Cyclin D1.	pasmc	90-95	cyclin D1	Homo sapiens	164-173
23286511-6	2013	The proliferation-promoting action of isoprenaline was abolished by a beta1-selective antagonist and was more effectively abolished by a beta2-selective antagonist; the mechanism for the action of the antagonists was a G0/G1 phase cell cycle arrest which was associated with decreased cyclin D1, CDK-4, CDK-6 and phospho-Rb expression.	Isoproterenol	38-50	cyclin D1	Homo sapiens	285-294
22746102-9	2013	These effects correlated with the reduction of vascular endothelial growth factor (VEGF), c-myc, and cyclin D1, and could be explained on the basis of inhibition of STAT3 tyrosine phosphorylation.	Tyrosine	171-179	cyclin D1	Homo sapiens	101-110
24289559-6	2013	Moreover, Triptolide treatment of PC-3 cells resulted in elevated mRNA levels of target genes (ADRB2, CDH1, CDKN2A and DAB2IP) negatively regulated by EZH2 as well as reduced mRNA levelsan of EZH2 positively regulated gene (cyclin D1).	triptolide	10-20	cyclin D1	Homo sapiens	224-233
23538439-5	2013	In addition, cardamonin suppressed the expression of cyclin D1 and c-myc, which are known beta-catenin/T cell factor (TCF)-dependent genes.	cardamonin	13-23	cyclin D1	Homo sapiens	53-62
24175297-5	2013	alpha-Mangostin significantly upregulated mRNA expression of cytochrome C and p21(WAF1) and downregulated that of cyclin D1, Akt1, and NFkappaB.	mangostin	0-15	cyclin D1	Homo sapiens	114-123
24175297-7	2013	8-Deoxygartanin significantly upregulated the mRNA expression of p21(WAF1) and downregulated that of cyclin D1 and NFkappaB.	8-deoxygartanin	0-15	cyclin D1	Homo sapiens	101-110
23607100-8	2013	The inhibitory effect of GW501516 on HPASMCs was associated with decreased expression of cyclin D1, cyclin D3, CDK2, and CDK4 as well as increased expression of the cell cycle inhibitory genes G0S2 and P27(kip1).	GW 501516	25-33	cyclin D1	Homo sapiens	89-98
24592121-0	2013	Expression of URG4/URGCP, Cyclin D1, Bcl-2, and Bax genes in retinoic acid treated SH-SY5Y human neuroblastoma cells.	Tretinoin	61-74	cyclin D1	Homo sapiens	26-35
24592121-6	2013	In this study, the effects of RA treatment on URG4/URGCP, CCND1, Bcl-2 and Bax gene expression changes in undifferentiated and differentiated SHSY5Y neuroblastoma cells was analyzed.	Tretinoin	30-32	cyclin D1	Homo sapiens	58-63
23878608-6	2013	Both tanshinone IIA and cryptotanshinone attenuated the expression of bcl-xL, survivin, and cyclin D1.	tanshinone	5-15	cyclin D1	Homo sapiens	92-101
23878608-6	2013	Both tanshinone IIA and cryptotanshinone attenuated the expression of bcl-xL, survivin, and cyclin D1.	cryptotanshinone	24-40	cyclin D1	Homo sapiens	92-101
24311896-8	2013	Both EGFR inhibitor AG1478 and PI3K inhibitor wortmannin inhibited the EGF-induced EGFR/PI3K/Akt/cyclinD1 signaling pathway concomitantly with inhibition of cell proliferation and cell cycle progression of EACKs.	RTKI cpd	20-26	cyclin D1	Homo sapiens	97-105
24311896-8	2013	Both EGFR inhibitor AG1478 and PI3K inhibitor wortmannin inhibited the EGF-induced EGFR/PI3K/Akt/cyclinD1 signaling pathway concomitantly with inhibition of cell proliferation and cell cycle progression of EACKs.	Wortmannin	46-56	cyclin D1	Homo sapiens	97-105
21676631-7	2013	Moreover, metformin down-regulated cyclin D1 expression and induced G0/G1 cell cycle arrest in these cells.	Metformin	10-19	cyclin D1	Homo sapiens	35-44
22391571-5	2013	Of particular interest is hNaa10p (human ARD1), the catalytic subunit of the NatA complex, which was coupled to a number of signaling molecules including hypoxia inducible factor-1alpha, beta-catenin/cyclin D1, TSC2/mammalian target of rapamycin, myosin light chain kinase , DNA methyltransferase1/E-cadherin and p21-activated kinase-interacting exchange factors (PIX)/Cdc42/Rac1.	N-acetyltryptophanamide	77-81	cyclin D1	Homo sapiens	200-209
22460364-5	2013	This effect, particularly evident for gamma-tocopherol, was associated with an up-regulation and increased activity of transglutaminase 2 (TG2), a reduced DNA synthesis and a remarkable decreased levels of cyclin D1 and cyclin E. Activation of TG2 suggests that gamma-tocopherol has an evident differentiative capacity on PC3 cells, leading to an increased expression of TG2, and reduced cyclin D1 and cyclin E levels, affecting cell cycle progression.	gamma-Tocopherol	38-54	cyclin D1	Homo sapiens	206-215
22460364-5	2013	This effect, particularly evident for gamma-tocopherol, was associated with an up-regulation and increased activity of transglutaminase 2 (TG2), a reduced DNA synthesis and a remarkable decreased levels of cyclin D1 and cyclin E. Activation of TG2 suggests that gamma-tocopherol has an evident differentiative capacity on PC3 cells, leading to an increased expression of TG2, and reduced cyclin D1 and cyclin E levels, affecting cell cycle progression.	gamma-Tocopherol	38-54	cyclin D1	Homo sapiens	388-397
23991964-4	2013	At the molecular level, our results further revealed that cyclin D1 expression was negatively regulated by miR-16.	mir-16	107-113	cyclin D1	Homo sapiens	58-67
23938089-9	2013	RESULTS: SC-1 and SC-43 induced more potent apoptosis than sorafenib, in association with downregulation of p-STAT3 and its downstream proteins cyclin D1 and survivin in a dose-dependent manner in breast cancer cell lines (HCC-1937, MDA-MB-468, MDA-MB-231, MDA-MB-453, SK-BR3, MCF-7).	Sorafenib	59-68	cyclin D1	Homo sapiens	144-153
23363659-7	2013	YXQ-EQ downregulated cyclin D1 expression and increased accumulation of cyclin-dependent kinase inhibitors p21(Cip1) and p27(Kip1), resulting in G1 cell cycle arrest.	yxq-eq	0-6	cyclin D1	Homo sapiens	21-30
23221619-7	2013	Treatment of A549 and H1299 cells with honokiol resulted in an increase in G 1 phase arrest, and a decrease in the levels of cyclin D1, D2 and cyclin dependent kinases.	honokiol	39-47	cyclin D1	Homo sapiens	125-134
23266736-5	2013	Rather, combined treatment with subeffective doses of gamma-tocotrienol and sesamin was found to induce G1 cell cycle arrest, and a corresponding decrease in cyclin D1, CDK2, CDK4, CDK6, phospho-Rb, and E2F1 levels, and increase in p27 and p16 levels.	plastochromanol 8	54-71	cyclin D1	Homo sapiens	158-167
23266736-5	2013	Rather, combined treatment with subeffective doses of gamma-tocotrienol and sesamin was found to induce G1 cell cycle arrest, and a corresponding decrease in cyclin D1, CDK2, CDK4, CDK6, phospho-Rb, and E2F1 levels, and increase in p27 and p16 levels.	sesamin	76-83	cyclin D1	Homo sapiens	158-167
23864022-3	2013	This event blocks de novo reactive oxygen species generation by Rac1-dependent NADPH oxidases, and thereby confers cellular protection from reactive oxygen species-induced DNA damage and cyclin D1-driven hyper-proliferation.	Reactive Oxygen Species	26-49	cyclin D1	Homo sapiens	187-196
23864022-3	2013	This event blocks de novo reactive oxygen species generation by Rac1-dependent NADPH oxidases, and thereby confers cellular protection from reactive oxygen species-induced DNA damage and cyclin D1-driven hyper-proliferation.	Reactive Oxygen Species	140-163	cyclin D1	Homo sapiens	187-196
23659452-4	2013	Concomitantly, beta-ionone-induced apoptosis and cell cycle arrest at the G1 phase in DU145 and PC-3 cells were shown by fluorescence microscopy, flow cytometry, and TUNEL reaction, and downregulation of cyclin-dependent kinase 4 (Cdk4) and cyclin D1 proteins.	beta-ionone	15-26	cyclin D1	Homo sapiens	241-250
24083669-0	2013	Effect of ursolic acid on MAPK in cyclin D1 signaling and RING-type E3 ligase (SCF E3s) in two endometrial cancer cell lines.	ursolic acid	10-22	cyclin D1	Homo sapiens	34-43
24083669-5	2013	Ursolic acid (UA) treatment of SNG-2 cells, an endometrial cancer cell line, decreased cyclin D1, pERK1/2, FBXW8, and Cullin1 levels in a dose- and time-dependent manner.	ursolic acid	0-12	cyclin D1	Homo sapiens	87-96
24083669-5	2013	Ursolic acid (UA) treatment of SNG-2 cells, an endometrial cancer cell line, decreased cyclin D1, pERK1/2, FBXW8, and Cullin1 levels in a dose- and time-dependent manner.	ursolic acid	14-16	cyclin D1	Homo sapiens	87-96
23859040-3	2013	ECG induced cell cycle arrest at the G0/G1-S phase border associated with the stimulation of p21, p-p53, and p53 and the suppression of cyclins D1 and B1.	epicatechin gallate	0-3	cyclin D1	Homo sapiens	136-153
24127655-6	2013	We furthermore show that EGCG effectively inhibits Wnt signaling, as evidenced by down-regulation of Wnt-responsive reporter gene activity and expression of the Wnt target genes MYC and CCND1.	epigallocatechin gallate	25-29	cyclin D1	Homo sapiens	186-191
23682781-7	2013	UA decreased the expression of cyclin-dependent kinase (CDK)4, CDK6, and cyclin D1 and increased the expression of CDK inhibitor (CDKI) p21/cip1 protein.	usnic acid	0-2	cyclin D1	Homo sapiens	73-82
23924855-6	2013	In addition, simvastatin blocked cells in the G1 phase of the cell cycle, downregulated cyclin D1 and CDKs protein expression, mediated the mitochondria-dependent caspase cascade by increasing caspase-3, -8, and -9 mRNA and protein expression, downregulated Xiap levels to induce cells apoptosis.	Simvastatin	13-24	cyclin D1	Homo sapiens	88-106
23255952-5	2013	Gefitinib treatment caused cell cycle arrest predominantly at the G1 phase, which is associated with TOB1 nuclear translocation and its interaction with cyclin D1.	Gefitinib	0-9	cyclin D1	Homo sapiens	153-162
23255952-7	2013	These results suggest that TOB1 interaction with cyclin D1 and nuclear translocation is directly involved in the gefitinib-induced anti-proliferative cell cycle arrest.	Gefitinib	113-122	cyclin D1	Homo sapiens	49-58
23924855-8	2013	Taken together, these results showed that the anticancer effect of simvastatin in lung cancer A549 cells via the inhibiting cell proliferation, influencing the cell cycle, downregulating cyclin D1 and CDKs expression, inducing apoptosis, and decreasing MMP-9 levels, possibly by inhibiting the activation of NF-kappaB.	Simvastatin	67-78	cyclin D1	Homo sapiens	187-196
23451189-9	2013	Curcumin potentiated 5-FU-induced expression or cleavage of pro-apoptotic proteins (caspase-8, -9, -3, PARP and Bax), and down-regulated anti-apoptotic (Bcl-xL) and proliferative (cyclin D1) proteins.	Curcumin	0-8	cyclin D1	Homo sapiens	180-189
22256788-5	2013	We propose that cyclin D1 may be a central molecule in the pathogenesis of CCSK, driven mainly by the sonic hedgehog and the nuclear factor-kappa B pathways and secondarily by the mammalian target of rapamycin complex mTORC2/PI3K/Akt pathway, heat shock protein 90, and possibly phospholipase D1.	ccsk	75-79	cyclin D1	Homo sapiens	16-25
22722256-0	2013	Inhibition of pancreatic cancer cell growth in vivo using a tetracycline-inducible cyclin D1 antisense expression system.	Tetracycline	60-72	cyclin D1	Homo sapiens	83-92
22722256-5	2013	RESULTS: In vitro removal of tetracycline induced cyclin D1 antisense cDNA expression and inhibited cyclin D1 expression and cyclin D1-associated kinase activity as well as anchorage-dependent and -independent growth.	Tetracycline	29-41	cyclin D1	Homo sapiens	50-59
22722256-5	2013	RESULTS: In vitro removal of tetracycline induced cyclin D1 antisense cDNA expression and inhibited cyclin D1 expression and cyclin D1-associated kinase activity as well as anchorage-dependent and -independent growth.	Tetracycline	29-41	cyclin D1	Homo sapiens	100-109
22722256-5	2013	RESULTS: In vitro removal of tetracycline induced cyclin D1 antisense cDNA expression and inhibited cyclin D1 expression and cyclin D1-associated kinase activity as well as anchorage-dependent and -independent growth.	Tetracycline	29-41	cyclin D1	Homo sapiens	100-109
23565238-0	2013	CG0009, a novel glycogen synthase kinase 3 inhibitor, induces cell death through cyclin D1 depletion in breast cancer cells.	cg0009	0-6	cyclin D1	Homo sapiens	81-90
23565238-5	2013	CG0009 treatment (1 micromol/L) completely ablated cyclin D1 expression in a time-dependent manner in all the cell lines examined, except T47D.	cg0009	0-6	cyclin D1	Homo sapiens	51-60
23451189-9	2013	Curcumin potentiated 5-FU-induced expression or cleavage of pro-apoptotic proteins (caspase-8, -9, -3, PARP and Bax), and down-regulated anti-apoptotic (Bcl-xL) and proliferative (cyclin D1) proteins.	Fluorouracil	21-25	cyclin D1	Homo sapiens	180-189
23194063-6	2012	Curcumin and RL197 inhibited RKO and SW480 colon cancer cell growth and induced apoptosis, and this was accompanied by downregulation of specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 and Sp-regulated genes including the epidermal growth factor receptor (EGFR), hepatocyte growth factor receptor (c-MET), survivin, bcl-2, cyclin D1 and NFkappaB (p65 and p50).	Curcumin	0-8	cyclin D1	Homo sapiens	339-348
23469066-6	2013	Real-time RT-PCR and western blot analyses showed that gamma-tocotrienol inhibited the expression level of beta-catenin, cyclin D1 and c-jun.	plastochromanol 8	55-72	cyclin D1	Homo sapiens	121-130
23169291-10	2012	Silencing of activin A expression by siRNA oligonucleotides further confirmed these results and led to reduced cyclin D1/3 expression.	Oligonucleotides	43-59	cyclin D1	Homo sapiens	111-122
23242714-11	2012	This was further confirmed by immunoblotting of the protein Cyclin D1, whose expression were found to be decreased in both curcumin and BDMC-A treatment.	Curcumin	123-131	cyclin D1	Homo sapiens	60-69
23242714-11	2012	This was further confirmed by immunoblotting of the protein Cyclin D1, whose expression were found to be decreased in both curcumin and BDMC-A treatment.	BDMC-A	136-142	cyclin D1	Homo sapiens	60-69
22438101-3	2012	Further, perifosine and curcumin synergistically increase intracellular level of reactive oxygen species and ceramide, and downregulate the expression of cyclin D1 and Bcl-2 in colorectal cancer cells.	perifosine	9-19	cyclin D1	Homo sapiens	154-163
22438101-3	2012	Further, perifosine and curcumin synergistically increase intracellular level of reactive oxygen species and ceramide, and downregulate the expression of cyclin D1 and Bcl-2 in colorectal cancer cells.	Curcumin	24-32	cyclin D1	Homo sapiens	154-163
22582896-5	2012	A mechanism study showed that scutellarin at doses of less than 10 muM induced cell cycle arrest at G0/G1 transition without the induction of cell apoptosis, which was accompanied by down-regulation of cyclin D1 and CDK4 expression.	scutellarin	30-41	cyclin D1	Homo sapiens	202-211
23661346-2	2013	MATERIAL AND METHOD: Immunohistochemical staining of cyclin D1 on formalin-fixed, paraffin-embedded tissue sections of odontogenic keratocysts (n=23), dentigerous cysts (n=20), radicular cysts (n=20) and glandular odontogenic cysts (n=5) was performed by standard EnVision method.	Formaldehyde	66-74	cyclin D1	Homo sapiens	53-62
23085518-6	2012	Mechanistically, enhancement of ROS production by T63 induced FOXO3a expression and nuclear translocation through activation of p38MAPK and inhibition of AKT, subsequently elevating the expression of FOXO3a target genes, including p21, p27, and Bim, and then increased the levels of activated caspase-3 and decreased the levels of cyclin D1.	Reactive Oxygen Species	32-35	cyclin D1	Homo sapiens	331-340
23552487-8	2012	Furthermore, blocking OGT activity using the potent inhibitor Ac-5SGlcNAc prevented serum-stimulated cyclin D1 synthesis and slightly delayed cell proliferation.	1,3,4,6-tetra-O-acetyl-5-thioglucopyranose	62-73	cyclin D1	Homo sapiens	101-110
22965904-8	2012	ATO treatment also reduced cyclin D1 expression which is a genetic hallmark of MCL and NF-kB expression which was reported to have a prosurvival role in some MCL cells.	ato	0-3	cyclin D1	Homo sapiens	27-36
23054864-7	2012	The results showed breast cancer cells respond in a diverse manner to LiCl, i.e., at lower concentrations (1, 5, and 10 mM), LiCl induces cell survival by inhibiting apoptosis through regulation of GSK-3beta, caspase-2, Bax, and cleaved caspase-7 and by activating anti-apoptotic proteins (Akt, beta-catenin, Bcl-2, and cyclin D1).	Lithium Chloride	125-129	cyclin D1	Homo sapiens	320-329
22828872-3	2012	Our recent studies suggested that formononetin inactivated IGF1/IGF1R-PI3K/Akt pathways and decreased cyclin D1 mRNA and protein expression in human breast cancer cells in vitro and in vivo.	formononetin	34-46	cyclin D1	Homo sapiens	102-111
22960157-4	2012	Dihydroceramides accumulation is associated with cyclin D1 expression modulation, delayed G1/S transition of cell cycle and increased autophagy.	dihydroceramide	0-16	cyclin D1	Homo sapiens	49-58
22814742-0	2012	Cyclin D1 degradation and p21 induction contribute to growth inhibition of colorectal cancer cells induced by epigallocatechin-3-gallate.	epigallocatechin gallate	110-136	cyclin D1	Homo sapiens	0-9
22814742-8	2012	RESULTS: We identified cyclin D1 and p21 as molecular targets of EGCG in human colorectal cancer cells.	epigallocatechin gallate	65-69	cyclin D1	Homo sapiens	23-32
22814742-10	2012	Furthermore, we found EGCG decreased cyclin D1 protein stability, therefore triggering ubiquitin-dependent proteasomal degradation.	epigallocatechin gallate	22-26	cyclin D1	Homo sapiens	37-46
22814742-13	2012	Namely, EGCG-induced cyclin D1 degradation and p21 transcriptional activation partially contribute to growth suppression in these cells.	epigallocatechin gallate	8-12	cyclin D1	Homo sapiens	21-30
22932665-8	2012	Furthermore, as compared with treatment with each agent alone, cotreatment with DZNep and PS caused greater depletion of EZH2, SUZ12, 3MeK27H3, and Cyclin D1 levels, whereas it induced greater expression of FBXO32, p16, p21, and p27.	3-deazaneplanocin	80-85	cyclin D1	Homo sapiens	148-157
23176676-14	2012	After lycorine treatment, cyclin D1 and cyclin-dependent kinase 4 expressions were inhibited and retinoblastoma protein phosphorylation was reduced.	lycorine	6-14	cyclin D1	Homo sapiens	26-35
22932665-8	2012	Furthermore, as compared with treatment with each agent alone, cotreatment with DZNep and PS caused greater depletion of EZH2, SUZ12, 3MeK27H3, and Cyclin D1 levels, whereas it induced greater expression of FBXO32, p16, p21, and p27.	Panobinostat	90-92	cyclin D1	Homo sapiens	148-157
23151022-11	2012	Metformin treatment led to a remarkable decrease of cyclin D1, cyclin-dependent kinase (CDK) 4 and CDK6 protein levels and phosphorylation of retinoblastoma protein, but did not affect p21 or p27 protein expression in OSCC cells.	Metformin	0-9	cyclin D1	Homo sapiens	52-61
23151022-13	2012	Metformin also markedly reduced the expression of cyclin D1 and increased the numbers of apoptotic cells in vivo, thus inhibiting the growth of OSCC xenografts.	Metformin	0-9	cyclin D1	Homo sapiens	50-59
22906881-9	2012	The estrogenic activity of nandrolone and stanozolol was further confirmed by their capacity to induce the expression of the ER-regulated gene, CCND1 encoding for the cell cycle regulator cyclin D1, which represents a key protein for the control of breast cancer cell proliferation.	Nandrolone	27-37	cyclin D1	Homo sapiens	144-149
23099809-1	2012	BACKGROUND: The aim of this study was to investigate the value of the cyclin D1 isoforms D1a and D1b as prognostic factors and their relevance as predictors of response to adjuvant chemotherapy with 5-fluorouracil and levamisole (5-FU/LEV) in colorectal cancer (CRC).	Fluorouracil	199-213	cyclin D1	Homo sapiens	70-79
23099809-1	2012	BACKGROUND: The aim of this study was to investigate the value of the cyclin D1 isoforms D1a and D1b as prognostic factors and their relevance as predictors of response to adjuvant chemotherapy with 5-fluorouracil and levamisole (5-FU/LEV) in colorectal cancer (CRC).	Levamisole	218-228	cyclin D1	Homo sapiens	70-79
22906881-9	2012	The estrogenic activity of nandrolone and stanozolol was further confirmed by their capacity to induce the expression of the ER-regulated gene, CCND1 encoding for the cell cycle regulator cyclin D1, which represents a key protein for the control of breast cancer cell proliferation.	Nandrolone	27-37	cyclin D1	Homo sapiens	188-197
22906881-9	2012	The estrogenic activity of nandrolone and stanozolol was further confirmed by their capacity to induce the expression of the ER-regulated gene, CCND1 encoding for the cell cycle regulator cyclin D1, which represents a key protein for the control of breast cancer cell proliferation.	Stanozolol	42-52	cyclin D1	Homo sapiens	144-149
22906881-9	2012	The estrogenic activity of nandrolone and stanozolol was further confirmed by their capacity to induce the expression of the ER-regulated gene, CCND1 encoding for the cell cycle regulator cyclin D1, which represents a key protein for the control of breast cancer cell proliferation.	Stanozolol	42-52	cyclin D1	Homo sapiens	188-197
23387080-10	2012	Alteronol could effectively inhibit the proliferation of human promyelocytic leukemia HL-60 cells inducing cell cycle arrest at G1 phase, as well as, alteration expression of cell cycle proteins level of CyclinD1 and pRb.	alteronol	0-9	cyclin D1	Homo sapiens	204-212
22935447-6	2012	We found that resveratrol indeed exhibited dose-dependent suppression of Wnt signaling, reduced the expression of Wnt target genes such as cyclin D1 and conductin, and inhibited the growth of Wnt-stimulated cells and Wnt-driven colorectal cancer cells.	Resveratrol	14-25	cyclin D1	Homo sapiens	139-148
23037503-2	2012	We investigated whether the NF-kB inhibitor, parthenolide, currently in cancer clinical trials, attenuates tumor promotion by modulating the epigenetically regulated NF-kB target genes, p21 and cyclin D1.	parthenolide	45-57	cyclin D1	Homo sapiens	194-203
23037503-5	2012	Furthermore, parthenolide decreased tumor promoter-induced NF-kB activity, increased p21, and decreased cyclin D1 expression.	parthenolide	13-25	cyclin D1	Homo sapiens	104-113
22811014-9	2012	The intracisternal administration of U0126 (an MEK inhibitor), previous to the excitotoxic lesion, decreased the activation of ERK1/2 and the expression of cyclin D1 and cyclin B in the hippocampus.	U 0126	37-42	cyclin D1	Homo sapiens	156-165
22915768-6	2012	In cultured SMCs, vinpocetine dose-dependently suppressed cell proliferation and caused G1-phase cell cycle arrest, which is associated with a decrease in cyclin D1 and an increase in p27Kip1 levels.	vinpocetine	18-29	cyclin D1	Homo sapiens	155-164
22964485-5	2012	We determined that the anti-MM activity of SLM6 was mediated by direct inhibition of cyclin-dependent kinase 9 (CDK9), which resulted in transcriptional repression of oncogenes that are known to drive MM progression (MAF, CCND1, MYC, and others).	slm6	43-47	cyclin D1	Homo sapiens	222-227
22874762-5	2012	Addition of calcitriol to HP medium (HP + CTR) further increased calcification and also enhanced the expression of osteogenic factors together with a significant elevation of nuclear beta-catenin levels and the expression of cyclin D1, axin 2, and VCAN.	Calcitriol	12-22	cyclin D1	Homo sapiens	225-234
22874762-5	2012	Addition of calcitriol to HP medium (HP + CTR) further increased calcification and also enhanced the expression of osteogenic factors together with a significant elevation of nuclear beta-catenin levels and the expression of cyclin D1, axin 2, and VCAN.	hp medium	26-35	cyclin D1	Homo sapiens	225-234
23114121-3	2012	The results indicated that after treated with MK886, the percentage of HL-60 cells decreased in G(0)/G(1) phase and increased in S phase, and expressions of mPGES-1, cyclin D1, P-Akt and C-MYC and synthesis of PGE(2) decreased significantly.	MK-886	46-51	cyclin D1	Homo sapiens	166-175
22982675-4	2012	Withaferin A also down-regulates the expression of STAT3 regulated genes such as Bcl-xL, Bcl-2, cyclin D1 and survivin.	withaferin A	0-12	cyclin D1	Homo sapiens	96-105
23017833-5	2012	Curcumin suppressed the activation of NF-kappaB via the inhibition of IkappaBalpha phosphorylation, and downregulated the expressions of Bcl-2 and CyclinD1 in ESCC cell lines.	Curcumin	0-8	cyclin D1	Homo sapiens	147-155
22694478-14	2012	Inhibition of HSP90 activity by 400 nmol/l 17-DMAG decreased protein levels of survivin, cyclin D1 and NF-kappaB protein levels, whereas increased p53 protein level.	17-(dimethylaminoethylamino)-17-demethoxygeldanamycin	43-50	cyclin D1	Homo sapiens	89-98
22762853-8	2012	GA-Me down-regulated the expression of various NF-kappaB-regulated genes including genes involved in cell proliferation (c-Myc and cyclin D1), anti-apoptosis (Bcl-2), invasion (MMP-9) and angiogenesis (VEGF, interleukin (IL)-6 and -8).	ganoderic acid Me	0-5	cyclin D1	Homo sapiens	131-140
23298477-4	2012	We determined that TRIAC could stimulate epidermal thickening in mice and promote human keratinocyte proliferation by activating Cyclin D1 expression and promoting entrance into S phase.	3,3',5-triiodothyroacetic acid	19-24	cyclin D1	Homo sapiens	129-138
22542550-8	2012	In U373 cells cyclin D1 mRNA and protein expression was induced by P after 6 and 8h of treatment, respectively, and this effect was blocked with RU 486.	Mifepristone	145-151	cyclin D1	Homo sapiens	14-23
23092573-6	2012	The mRNA expression of cyclin D1 and survivin was seen in all RD cells, but was significantly lower in RD cells treated with matrine than in those that were not treated with matrine (P&lt;0.01).	matrine	125-132	cyclin D1	Homo sapiens	23-32
23092573-6	2012	The mRNA expression of cyclin D1 and survivin was seen in all RD cells, but was significantly lower in RD cells treated with matrine than in those that were not treated with matrine (P&lt;0.01).	matrine	174-181	cyclin D1	Homo sapiens	23-32
23092573-7	2012	There were significant differences in cyclin D1 mRNA level among the RD cells treated with 0.5, 1.0, and 1.5 mg/mL of matrine (P&lt;0.05), while there was significant difference in survivin mRNA level between the RD cells treated with 0.5 and 1.5 mg/mL of matrine (P&lt;0.05).	matrine	118-125	cyclin D1	Homo sapiens	38-47
23114121-4	2012	It is concluded that MK886 can arrest HL-60 cells in G(0)/G(1) phase, the mechanism of which is possibly associated to inhibition of mPGES-1 expression, reduction of PGE(2) synthesis, suppression of Akt phosphorylation and C-MYC expression, down-regulation of cyclin D1 expression.	MK-886	21-26	cyclin D1	Homo sapiens	260-269
22820424-0	2012	Baicalein induces G1 arrest in oral cancer cells by enhancing the degradation of cyclin D1 and activating AhR to decrease Rb phosphorylation.	baicalein	0-9	cyclin D1	Homo sapiens	81-90
22410463-0	2012	Gambogenic acid induces G1 arrest via GSK3beta-dependent cyclin D1 degradation and triggers autophagy in lung cancer cells.	neo-gambogic acid	0-15	cyclin D1	Homo sapiens	57-66
22820424-9	2012	When cells were pre-treated with LiCl, the inhibitor of GSK-3beta, the decrease of cyclin D1 was blocked and the reduction of pRb was recovered.	Lithium Chloride	33-37	cyclin D1	Homo sapiens	83-92
22728329-8	2012	AS or Ly294002, but not H-89, decreased PKB/Akt activation as well as the nuclear localization of beta-catenin and cyclin D1 and increased the plasma membrane localization of beta-catenin with E-cadherin, suggesting that these processes are regulated by the PKB pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	6-14	cyclin D1	Homo sapiens	115-124
22884800-8	2012	NF-kappaB inhibitor BAY 11-7082 reversed the role of CARMA3 on cyclin D1 upregulation.	3-(4-methylphenylsulfonyl)-2-propenenitrile	20-31	cyclin D1	Homo sapiens	63-72
24280698-1	2012	The histone deacetylase (HDAC) inhibitors, butyrate and trichostatin A (TSA), are epigenetic histone modifiers and proliferation inhibitors by downregulating cyclin D1, a positive cell cycle regulator, and upregulating p21Cip1 and INK family of proteins, negative cell cycle regulators.	Butyrates	43-51	cyclin D1	Homo sapiens	158-167
24280698-1	2012	The histone deacetylase (HDAC) inhibitors, butyrate and trichostatin A (TSA), are epigenetic histone modifiers and proliferation inhibitors by downregulating cyclin D1, a positive cell cycle regulator, and upregulating p21Cip1 and INK family of proteins, negative cell cycle regulators.	trichostatin A	56-70	cyclin D1	Homo sapiens	158-167
24280698-1	2012	The histone deacetylase (HDAC) inhibitors, butyrate and trichostatin A (TSA), are epigenetic histone modifiers and proliferation inhibitors by downregulating cyclin D1, a positive cell cycle regulator, and upregulating p21Cip1 and INK family of proteins, negative cell cycle regulators.	trichostatin A	72-75	cyclin D1	Homo sapiens	158-167
24280698-2	2012	Our recent study indicated cyclin D1 upregulation in vascular smooth muscle cells (VSMC) that are proliferation-arrested by butyrate.	Butyrates	124-132	cyclin D1	Homo sapiens	27-36
24280698-3	2012	Here we investigate whether cyclin D1 upregulation is a unique response of VSMC to butyrate or a general response to HDAC inhibitors (HDACi) by evaluating the effects of butyrate and TSA on VSMC.	vsmc	75-79	cyclin D1	Homo sapiens	28-37
24280698-3	2012	Here we investigate whether cyclin D1 upregulation is a unique response of VSMC to butyrate or a general response to HDAC inhibitors (HDACi) by evaluating the effects of butyrate and TSA on VSMC.	Butyrates	83-91	cyclin D1	Homo sapiens	28-37
24280698-5	2012	Conversely, cyclin D1 is upregulated by butyrate and inhibited by TSA.	Butyrates	40-48	cyclin D1	Homo sapiens	12-21
24280698-5	2012	Conversely, cyclin D1 is upregulated by butyrate and inhibited by TSA.	trichostatin A	66-69	cyclin D1	Homo sapiens	12-21
24280698-6	2012	Assessment of glycogen synthase 3-dependent phosphorylation, subcellular localization and transcription of cyclin D1 indicates that differential effects of butyrate and TSA on cyclin D1 levels are linked to disparity in cyclin D1 gene expression.	Butyrates	156-164	cyclin D1	Homo sapiens	107-116
24280698-6	2012	Assessment of glycogen synthase 3-dependent phosphorylation, subcellular localization and transcription of cyclin D1 indicates that differential effects of butyrate and TSA on cyclin D1 levels are linked to disparity in cyclin D1 gene expression.	Butyrates	156-164	cyclin D1	Homo sapiens	176-185
24280698-6	2012	Assessment of glycogen synthase 3-dependent phosphorylation, subcellular localization and transcription of cyclin D1 indicates that differential effects of butyrate and TSA on cyclin D1 levels are linked to disparity in cyclin D1 gene expression.	Butyrates	156-164	cyclin D1	Homo sapiens	176-185
24280698-6	2012	Assessment of glycogen synthase 3-dependent phosphorylation, subcellular localization and transcription of cyclin D1 indicates that differential effects of butyrate and TSA on cyclin D1 levels are linked to disparity in cyclin D1 gene expression.	trichostatin A	169-172	cyclin D1	Homo sapiens	107-116
24280698-6	2012	Assessment of glycogen synthase 3-dependent phosphorylation, subcellular localization and transcription of cyclin D1 indicates that differential effects of butyrate and TSA on cyclin D1 levels are linked to disparity in cyclin D1 gene expression.	trichostatin A	169-172	cyclin D1	Homo sapiens	176-185
24280698-6	2012	Assessment of glycogen synthase 3-dependent phosphorylation, subcellular localization and transcription of cyclin D1 indicates that differential effects of butyrate and TSA on cyclin D1 levels are linked to disparity in cyclin D1 gene expression.	trichostatin A	169-172	cyclin D1	Homo sapiens	176-185
24280698-7	2012	Disparity in butyrate- and TSA-induced cyclin D1 may influence transcriptional regulation of genes that are associated with changes in cellular morphology/cellular effects that these HDACi confer on VSMC, as a transcriptional modulator.	Butyrates	13-21	cyclin D1	Homo sapiens	39-48
24280698-7	2012	Disparity in butyrate- and TSA-induced cyclin D1 may influence transcriptional regulation of genes that are associated with changes in cellular morphology/cellular effects that these HDACi confer on VSMC, as a transcriptional modulator.	trichostatin A	27-30	cyclin D1	Homo sapiens	39-48
22460505-4	2012	Cell cycle analysis indicated thioridazine induced the down-regulation of cyclin D1, cyclin A and CDK4, and the induction of p21 and p27, a cyclin-dependent kinase inhibitor.	Thioridazine	30-42	cyclin D1	Homo sapiens	74-83
22728329-11	2012	PGE(2)via EP induces CREB phosphorylation by the PKA pathway and regulates beta-catenin and cyclin D1 cellular localization by PKB/Akt pathway.	Prostaglandins E	0-3	cyclin D1	Homo sapiens	92-101
22791882-3	2012	The protein synthesis inhibitor silvestrol has potent activity in B-cell leukemias via the mitochondrial pathway of apoptosis, and also reduces cyclin D1 expression in breast cancer and lymphoma cell lines.	silvestrol	32-42	cyclin D1	Homo sapiens	144-153
22791882-4	2012	We hypothesized that this dual activity of silvestrol would make it especially effective in malignancies driven by aberrant cyclin D1 expression.	silvestrol	43-53	cyclin D1	Homo sapiens	124-133
23019415-0	2012	Metronomic ceramide analogs inhibit angiogenesis in pancreatic cancer through up-regulation of caveolin-1 and thrombospondin-1 and down-regulation of cyclin D1.	Ceramides	11-19	cyclin D1	Homo sapiens	150-159
22735500-6	2012	At 1.0 x 10(-10), 1.0 x 10(-8), and 1.0 x 10(-6)mol/L, BPA promoted more cells to enter into G2/M phase and caused an increase in the expression of cyclinD1 and CDK4.	bisphenol A	55-58	cyclin D1	Homo sapiens	148-156
22847216-0	2012	Involvement of the cAMP response element binding protein, CREB, and cyclin D1 in LPA-induced proliferation of P19 embryonic carcinoma cells.	lysophosphatidic acid	81-84	cyclin D1	Homo sapiens	68-77
22847216-6	2012	Involvement of cyclin D1 in LPA-induced P19 cell proliferation was verified by immunoblot analysis in combination with pharmacological inhibitor treatment.	lysophosphatidic acid	28-31	cyclin D1	Homo sapiens	15-24
22847216-7	2012	Furthermore, LPA up-regulated CRE-harboring cyclin D1 promoter activity, suggesting that CREB and cyclin D1 play significant roles in LPA-induced proliferation of P19 embryonic carcinoma cells.	lysophosphatidic acid	13-16	cyclin D1	Homo sapiens	44-53
22847216-7	2012	Furthermore, LPA up-regulated CRE-harboring cyclin D1 promoter activity, suggesting that CREB and cyclin D1 play significant roles in LPA-induced proliferation of P19 embryonic carcinoma cells.	lysophosphatidic acid	13-16	cyclin D1	Homo sapiens	98-107
22749963-0	2012	Suberoylanilide hydroxamic acid (SAHA) inhibits EGF-induced cell transformation via reduction of cyclin D1 mRNA stability.	Vorinostat	0-31	cyclin D1	Homo sapiens	97-106
22710431-8	2012	Moreover, expression of Cyclin D1 increased, whereas expression of Cyclin A decreased after treatment with PEG-liposomal oxaliplatin.	Oxaliplatin	121-132	cyclin D1	Homo sapiens	24-33
22710431-11	2012	The effect of PEG-liposomal oxaliplatin on apoptosis of SW480 human colorectal cancer cells may be through regulation of expression of Cyclin A or Cyclin D1, as well as pro-apoptotic and anti-apoptotic proteins.	Polyethylene Glycols	14-17	cyclin D1	Homo sapiens	147-156
22710431-11	2012	The effect of PEG-liposomal oxaliplatin on apoptosis of SW480 human colorectal cancer cells may be through regulation of expression of Cyclin A or Cyclin D1, as well as pro-apoptotic and anti-apoptotic proteins.	Oxaliplatin	28-39	cyclin D1	Homo sapiens	147-156
22749963-6	2012	This notion was supported by the results that treatment of cells with SAHA decreased the half-life of cyclin D1 mRNA from 6.95 h to 2.57 h. Consistent with downregulation of cyclin D1 mRNA stability, SAHA treatment also attenuated HuR expression, which has been well-characterized as a positive regulator of cyclin D1 mRNA stability.	Vorinostat	70-74	cyclin D1	Homo sapiens	174-183
22749963-6	2012	This notion was supported by the results that treatment of cells with SAHA decreased the half-life of cyclin D1 mRNA from 6.95 h to 2.57 h. Consistent with downregulation of cyclin D1 mRNA stability, SAHA treatment also attenuated HuR expression, which has been well-characterized as a positive regulator of cyclin D1 mRNA stability.	Vorinostat	200-204	cyclin D1	Homo sapiens	102-111
22749963-7	2012	Thus, our study identifies a novel mechanism responsible for SAHA inhibiting cell transformation via decreasing cyclin D1 mRNA stability and induction of G0/G1 growth arrest in Cl41 cells.	Vorinostat	61-65	cyclin D1	Homo sapiens	112-121
22683510-4	2012	Treatment of U87 cells with 1.0muM CIL-102 resulted in phosphorylation of extracellular signal-related kinase (ERK1/2), downregulation of cell cycle-related proteins (cyclin A, cyclin B, cyclin D1, and cdk1), and phosphorylation of cdk1Tyr(15) and Cdc25cSer(216).	1-(4-(furo(2,3-b)quinolin-4-ylamino)phenyl)ethanone	35-42	cyclin D1	Homo sapiens	187-196
22422660-7	2012	Combined administration of furanodiene and TAM led to marked increase in growth inhibition, cell cycle arrest and pro-apoptotic activity in ERa-positive cells compared to individual agent, and enhanced the down-regulation of p-cyclin D1, cyclin D1, CDK2, CDK6, p-Rb, Rb and p-p44, and the up-regulation of p27, Bax and Bad, but did not show increased cytotoxicity in ERa-negative MCF-10A non-tumorigenic breast epithelial cells.	furanodiene	27-38	cyclin D1	Homo sapiens	227-236
22422660-7	2012	Combined administration of furanodiene and TAM led to marked increase in growth inhibition, cell cycle arrest and pro-apoptotic activity in ERa-positive cells compared to individual agent, and enhanced the down-regulation of p-cyclin D1, cyclin D1, CDK2, CDK6, p-Rb, Rb and p-p44, and the up-regulation of p27, Bax and Bad, but did not show increased cytotoxicity in ERa-negative MCF-10A non-tumorigenic breast epithelial cells.	furanodiene	27-38	cyclin D1	Homo sapiens	238-247
22422660-7	2012	Combined administration of furanodiene and TAM led to marked increase in growth inhibition, cell cycle arrest and pro-apoptotic activity in ERa-positive cells compared to individual agent, and enhanced the down-regulation of p-cyclin D1, cyclin D1, CDK2, CDK6, p-Rb, Rb and p-p44, and the up-regulation of p27, Bax and Bad, but did not show increased cytotoxicity in ERa-negative MCF-10A non-tumorigenic breast epithelial cells.	Tamoxifen	43-46	cyclin D1	Homo sapiens	227-236
22422660-7	2012	Combined administration of furanodiene and TAM led to marked increase in growth inhibition, cell cycle arrest and pro-apoptotic activity in ERa-positive cells compared to individual agent, and enhanced the down-regulation of p-cyclin D1, cyclin D1, CDK2, CDK6, p-Rb, Rb and p-p44, and the up-regulation of p27, Bax and Bad, but did not show increased cytotoxicity in ERa-negative MCF-10A non-tumorigenic breast epithelial cells.	Tamoxifen	43-46	cyclin D1	Homo sapiens	238-247
22562416-4	2012	In both investigated malignant glioma cell lines, triptolide repressed cell proliferation via inducing cell cycle arrest in G0/G1 phase, associated with downregulation of G0/G1 cell cycle regulators cyclin D1, CDK4, and CDK6 followed by reduced phosphorylation of retinoblastoma protein (Rb).	triptolide	50-60	cyclin D1	Homo sapiens	199-208
21988060-8	2012	Coimmunoprecipitation further confirmed that there was an interaction between phosphorylation of ERK and cyclin D1, CDK4, cyclin B1, or CDK1, which was weaken in the presence of melatonin or PD98059.	Melatonin	178-187	cyclin D1	Homo sapiens	105-114
21988060-8	2012	Coimmunoprecipitation further confirmed that there was an interaction between phosphorylation of ERK and cyclin D1, CDK4, cyclin B1, or CDK1, which was weaken in the presence of melatonin or PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	191-198	cyclin D1	Homo sapiens	105-114
23099809-1	2012	BACKGROUND: The aim of this study was to investigate the value of the cyclin D1 isoforms D1a and D1b as prognostic factors and their relevance as predictors of response to adjuvant chemotherapy with 5-fluorouracil and levamisole (5-FU/LEV) in colorectal cancer (CRC).	Fluorouracil	230-234	cyclin D1	Homo sapiens	70-79
23099809-1	2012	BACKGROUND: The aim of this study was to investigate the value of the cyclin D1 isoforms D1a and D1b as prognostic factors and their relevance as predictors of response to adjuvant chemotherapy with 5-fluorouracil and levamisole (5-FU/LEV) in colorectal cancer (CRC).	Levamisole	235-238	cyclin D1	Homo sapiens	70-79
22749963-0	2012	Suberoylanilide hydroxamic acid (SAHA) inhibits EGF-induced cell transformation via reduction of cyclin D1 mRNA stability.	Vorinostat	33-37	cyclin D1	Homo sapiens	97-106
22749963-1	2012	Suberoylanilide hydroxamic acid (SAHA) inhibiting cancer cell growth has been associated with its downregulation of cyclin D1 protein expression at transcription level or translation level.	Vorinostat	0-31	cyclin D1	Homo sapiens	116-125
22749963-1	2012	Suberoylanilide hydroxamic acid (SAHA) inhibiting cancer cell growth has been associated with its downregulation of cyclin D1 protein expression at transcription level or translation level.	Vorinostat	33-37	cyclin D1	Homo sapiens	116-125
22749963-2	2012	Here, we have demonstrated that SAHA inhibited EGF-induced Cl41 cell transformation via the decrease of cyclin D1 mRNA stability and induction of G0/G1 growth arrest.	Vorinostat	32-36	cyclin D1	Homo sapiens	104-113
22749963-3	2012	We found that SAHA treatment resulted in the dramatic inhibition of EGF-induced cell transformation, cyclin D1 protein expression and induction of G0/G1 growth arrest.	Vorinostat	14-18	cyclin D1	Homo sapiens	101-110
22749963-4	2012	Further studies showed that SAHA downregulation of cyclin D1 was only observed with endogenous cyclin D1, but not with reconstitutionally expressed cyclin D1 in the same cells, excluding the possibility of SAHA regulating cyclin D1 at level of protein degradation.	Vorinostat	28-32	cyclin D1	Homo sapiens	51-60
22749963-4	2012	Further studies showed that SAHA downregulation of cyclin D1 was only observed with endogenous cyclin D1, but not with reconstitutionally expressed cyclin D1 in the same cells, excluding the possibility of SAHA regulating cyclin D1 at level of protein degradation.	Vorinostat	28-32	cyclin D1	Homo sapiens	95-104
22749963-4	2012	Further studies showed that SAHA downregulation of cyclin D1 was only observed with endogenous cyclin D1, but not with reconstitutionally expressed cyclin D1 in the same cells, excluding the possibility of SAHA regulating cyclin D1 at level of protein degradation.	Vorinostat	28-32	cyclin D1	Homo sapiens	95-104
22749963-4	2012	Further studies showed that SAHA downregulation of cyclin D1 was only observed with endogenous cyclin D1, but not with reconstitutionally expressed cyclin D1 in the same cells, excluding the possibility of SAHA regulating cyclin D1 at level of protein degradation.	Vorinostat	28-32	cyclin D1	Homo sapiens	95-104
22749963-5	2012	Moreover, SAHA inhibited EGF-induced cyclin d1 mRNA level, whereas it did not show any inhibitory effect on cyclin D1 promoter-driven luciferase reporter activity under the same experimental conditions, suggesting that SAHA may decrease cyclin D1 mRNA stability.	Vorinostat	10-14	cyclin D1	Homo sapiens	37-46
22749963-6	2012	This notion was supported by the results that treatment of cells with SAHA decreased the half-life of cyclin D1 mRNA from 6.95 h to 2.57 h. Consistent with downregulation of cyclin D1 mRNA stability, SAHA treatment also attenuated HuR expression, which has been well-characterized as a positive regulator of cyclin D1 mRNA stability.	Vorinostat	70-74	cyclin D1	Homo sapiens	102-111
22749963-6	2012	This notion was supported by the results that treatment of cells with SAHA decreased the half-life of cyclin D1 mRNA from 6.95 h to 2.57 h. Consistent with downregulation of cyclin D1 mRNA stability, SAHA treatment also attenuated HuR expression, which has been well-characterized as a positive regulator of cyclin D1 mRNA stability.	Vorinostat	70-74	cyclin D1	Homo sapiens	174-183
22524974-3	2012	EXPERIMENTAL DESIGN: We performed preclinical studies using BMMNCs from patients with MDS and AML to examine the effects of the styryl sulfone ON 01910.Na on cyclin D1 accumulation, aneuploidy, and CD34+ blast percentage.	Styryl sulfone	128-142	cyclin D1	Homo sapiens	158-167
22751440-0	2012	Chenodeoxycholic acid through a TGR5-dependent CREB signaling activation enhances cyclin D1 expression and promotes human endometrial cancer cell proliferation.	Chenodeoxycholic Acid	0-21	cyclin D1	Homo sapiens	82-91
22705907-4	2012	The results obtained showed cell cycle regulatory proteins, cdk4 along with its activator cyclin D1, and PCNA increased while p27, an endogenous cyclin-dependent kinase inhibitor, deceased in glutamate-treated astrocytes in vitro.	Glutamic Acid	192-201	cyclin D1	Homo sapiens	90-99
22664862-7	2012	This is the first report demonstrating that PAG inhibits             the proliferation and invasion potential of prostate cancer cells via the interaction             with RasGAP to recruit RasGAP to the cell membrane, where RasGAP hydrolyzes GTP             to GDP, reduces the level of activated Ras, and ultimately suppresses the activation             of ERK1/2, cyclin D1 and other effectors of the Ras signaling pathway.	phenylacetylglycine	44-47	cyclin D1	Homo sapiens	367-376
22751440-5	2012	Low concentrations of CDCA are able to stimulate Ishikawa cell growth by inducing a significant increase in Cyclin D1 protein and mRNA expression through the activation of the membrane G protein-coupled receptor (TGR5)-dependent pathway.	Chenodeoxycholic Acid	22-26	cyclin D1	Homo sapiens	108-117
22751440-6	2012	Dissecting the molecular mechanism underlying this effect by mutagenesis, EMSA and ChIP analysis revealed that CDCA-induced Cyclin D1 expression requires the enhanced recruitment of the transcription factor CREB on the cyclic AMP-responsive element motif within the Cyclin D1 gene proximal promoter.	Chenodeoxycholic Acid	111-115	cyclin D1	Homo sapiens	124-133
22751440-6	2012	Dissecting the molecular mechanism underlying this effect by mutagenesis, EMSA and ChIP analysis revealed that CDCA-induced Cyclin D1 expression requires the enhanced recruitment of the transcription factor CREB on the cyclic AMP-responsive element motif within the Cyclin D1 gene proximal promoter.	Chenodeoxycholic Acid	111-115	cyclin D1	Homo sapiens	266-275
22751440-6	2012	Dissecting the molecular mechanism underlying this effect by mutagenesis, EMSA and ChIP analysis revealed that CDCA-induced Cyclin D1 expression requires the enhanced recruitment of the transcription factor CREB on the cyclic AMP-responsive element motif within the Cyclin D1 gene proximal promoter.	Cyclic AMP	219-229	cyclin D1	Homo sapiens	124-133
22751440-6	2012	Dissecting the molecular mechanism underlying this effect by mutagenesis, EMSA and ChIP analysis revealed that CDCA-induced Cyclin D1 expression requires the enhanced recruitment of the transcription factor CREB on the cyclic AMP-responsive element motif within the Cyclin D1 gene proximal promoter.	Cyclic AMP	219-229	cyclin D1	Homo sapiens	266-275
22739413-10	2012	RESULTS: The results suggests that DADS decreases the survival rate of androgen independent prostate cancer cells by modulating the expression of IGF system, which leads to inhibition of phosphorylation of Akt, thereby inhibits cell cycle progression and survival by lowering the expression of cyclin D1, NFkB and anti-apoptotic Bcl-2 molecule and increasing the level of pro-apoptotic (Bad and Bax) signaling molecules which leads to apoptosis.	diallyl disulfide	35-39	cyclin D1	Homo sapiens	294-303
22580126-10	2012	At higher concentrations, 4-HNE decreased both cell survival and proliferation as evidenced by MTT assays and EdU incorporation as well as decreased expression of cyclin D1 and beta-catenin, an effect only moderately increased by the addition of hydrogen peroxide.	Hydrogen Peroxide	246-263	cyclin D1	Homo sapiens	163-172
22753740-5	2012	Molecular analysis suggested that DHS inhibited cathepsin-mediated pro-survival signaling [pAKT: phosphorylated protein kinase B; BCL-2: B-cell lymphoma 2 and cyclin D1] and induced pro-apoptotic markers such as BAX [BCL-2-associated X protein] and cleaved caspase-3.	methyl 8-(3-furyl)-2a,4,5,5a,6,6a,8,9,9a,10a,10b,10c-dodecahydro-3-hydroxy-2a,5a,6a,7-tetramethyl-5-(3-methylbut-2-enoyloxy)-2H,3H-cyclopenta(4',5')furo(2',3'-6,5)benzo(cd)isobenzofuran-6-acetate	34-37	cyclin D1	Homo sapiens	159-168
22739938-0	2012	MiR-138 suppressed nasopharyngeal carcinoma growth and tumorigenesis by targeting the CCND1 oncogene.	mir-138	0-7	cyclin D1	Homo sapiens	86-91
22739938-4	2012	Moreover, we identified the cyclin D1 (CCND1) gene as a novel direct target of miR-138.	mir-138	79-86	cyclin D1	Homo sapiens	28-37
22739938-4	2012	Moreover, we identified the cyclin D1 (CCND1) gene as a novel direct target of miR-138.	mir-138	79-86	cyclin D1	Homo sapiens	39-44
22739938-5	2012	In consistent with the knocked-down expression of CCND1, overexpression of miR-138 inhibited cell growth and cell cycle progression in NPC cells.	mir-138	75-82	cyclin D1	Homo sapiens	50-55
22739938-7	2012	Taken together, our findings suggest that miR-138 might be a tumor suppressor in NPC, which is exerted partially by inhibiting CCND1 expression.	mir-138	42-49	cyclin D1	Homo sapiens	127-132
22565393-0	2012	Increased expression of cyclin-D1 on trephine bone marrow biopsies independently predicts for shorter overall survival in patients with multiple myeloma treated with novel agents.	trephine	37-45	cyclin D1	Homo sapiens	24-33
22716215-11	2012	The combination of 5-FU and chloroquine induced G1 arrest, up-regulation of p27 and p53, and down-regulation of CDK2 and cyclin D1.	Fluorouracil	19-23	cyclin D1	Homo sapiens	121-130
22716215-11	2012	The combination of 5-FU and chloroquine induced G1 arrest, up-regulation of p27 and p53, and down-regulation of CDK2 and cyclin D1.	Chloroquine	28-39	cyclin D1	Homo sapiens	121-130
22406084-7	2012	A marked reduction of cyclin D1 and of CDK4 expression was evident in the cells transfected with Cav-1 siRNA and consequently of phospho-Rb on ser(795) and ser(780).	Serine	143-146	cyclin D1	Homo sapiens	22-31
22406084-7	2012	A marked reduction of cyclin D1 and of CDK4 expression was evident in the cells transfected with Cav-1 siRNA and consequently of phospho-Rb on ser(795) and ser(780).	Serine	156-159	cyclin D1	Homo sapiens	22-31
22801507-10	2012	Furthermore, treatment of these cells with HO-3867 resulted in decreased expression of pTyr705 and its downstream targets cyclin D1, Bcl-2 and survivin.	ptyr705	87-94	cyclin D1	Homo sapiens	122-131
22580126-10	2012	At higher concentrations, 4-HNE decreased both cell survival and proliferation as evidenced by MTT assays and EdU incorporation as well as decreased expression of cyclin D1 and beta-catenin, an effect only moderately increased by the addition of hydrogen peroxide.	4-hydroxy-2-nonenal	26-31	cyclin D1	Homo sapiens	163-172
22535971-8	2012	DHT also inhibited basal (P &lt; 0.05) and E(2)-induced expression of cyclin-D1 mRNA (P &lt; 0.05).	Dihydrotestosterone	0-3	cyclin D1	Homo sapiens	70-79
22204713-11	2012	GSK pathway-mediated regulation of beta-catenin or cyclin D1 expression does not appear operative in papillary thyroid carcinoma.	gsk	0-3	cyclin D1	Homo sapiens	51-60
21820300-5	2012	However, knockdown with small interfering RNA (siRNA) of p21 or transfection with cyclin D1/Cdk4 binding site-mutated p21 abrogated MH-induced cell growth inhibition, inhibition of NF-kappaB activity as well as expression of cyclin D1 and Cdk4.	4-O-methylhonokiol	132-134	cyclin D1	Homo sapiens	82-91
22382785-6	2012	Moreover, we found that t-AUCB induces cell-cycle G0/G1 phase arrest by regulating Cyclin D1 mRNA and protein levels and CDC2 (Thr161) phosphorylation level.	4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid	24-30	cyclin D1	Homo sapiens	83-92
21852086-6	2012	Furthermore, gamma-tocotrienol suppressed the expression of downstream target genes such as c-myc, cyclin D1 and survivin.	plastochromanol 8	13-30	cyclin D1	Homo sapiens	99-108
21820300-5	2012	However, knockdown with small interfering RNA (siRNA) of p21 or transfection with cyclin D1/Cdk4 binding site-mutated p21 abrogated MH-induced cell growth inhibition, inhibition of NF-kappaB activity as well as expression of cyclin D1 and Cdk4.	4-O-methylhonokiol	132-134	cyclin D1	Homo sapiens	225-234
22734486-12	2012	Cafestol and kahweol modulated the promoter activity and protein expression level of the Sp1 regulatory genes including Cyclin D1, Mcl-1, and Survivin in mesothelioma cells.	cafestol	0-8	cyclin D1	Homo sapiens	120-129
21989330-0	2012	The Cyclin D1 (CCND1) A870G polymorphism predicts clinical outcome to lapatinib and capecitabine in HER2-positive metastatic breast cancer.	Lapatinib	70-79	cyclin D1	Homo sapiens	4-13
22623533-3	2012	BP-1-102-mediated inhibition of aberrantly active Stat3 in tumor cells suppresses the expression of c-Myc, Cyclin D1, Bcl-xL, Survivin, VEGF, and Kruppel-like factor 8, which is identified as a Stat3 target gene that promotes Stat3-mediated breast tumor cell migration and invasion.	BP-1-102	0-8	cyclin D1	Homo sapiens	107-116
23552696-11	2012	In this study, we present a newly discovered DDR regarding the AKT/cyclin D1/Cdk4 pathway in response to radiation in CSCs.	ddr	45-48	cyclin D1	Homo sapiens	67-76
22323434-6	2012	RESULTS: Patients with tumors that were strongly positive for cyclin D1 and FADD had reduced overall (OS; P = .003 and P &lt; .001), disease-specific (DSS; P = .039 and P &lt; .001), and disease-free (DFS; P = .026 and P &lt; .001) survival, respectively.	dss	151-154	cyclin D1	Homo sapiens	62-71
22490335-5	2012	This miRNA classifier showed consistent results in formalin-fixed paraffin-embedded tissues and was able to distinguish cyclin D1-negative MCL from other lymphomas.	Formaldehyde	51-59	cyclin D1	Homo sapiens	120-129
22490335-5	2012	This miRNA classifier showed consistent results in formalin-fixed paraffin-embedded tissues and was able to distinguish cyclin D1-negative MCL from other lymphomas.	Paraffin	66-74	cyclin D1	Homo sapiens	120-129
22504904-7	2012	The genes downstream of STAT3 (ie, Survivin, Mcl-1, Bcl-2 and Cyclin D1) were significantly down-regulated after exposure to celecoxib (25 and 50 mumol/L).	Celecoxib	125-134	cyclin D1	Homo sapiens	62-71
22394507-7	2012	Interestingly, quercetin also modulated the expression of two target genes regulated by STAT3, i.e. cyclin D1 and matrix metalloproteinase-2 (MMP-2).	Quercetin	15-24	cyclin D1	Homo sapiens	100-109
22394507-8	2012	Moreover, quercetin reduced the recruitment of STAT3 at the cyclin D1 promoter and inhibited Rb phosphorylation in the presence of IL-6.	Quercetin	10-19	cyclin D1	Homo sapiens	60-69
22387197-8	2012	Curcumin treatment of leukemic cells also downregulates the expression of the inhibitor of apoptosis proteins (IAPs), phospho-Akt, c-Myc, and cyclin D1.	Curcumin	0-8	cyclin D1	Homo sapiens	142-151
22391221-4	2012	DHA concentration-dependently inhibited hPASMC proliferation, induced G1 cell cycle arrest, and decreased cyclin D1 protein expression.	Docosahexaenoic Acids	0-3	cyclin D1	Homo sapiens	106-115
21732360-8	2012	On the contrary, quercetin acted similarly to E2 by increasing the levels of the oncosuppressor protein PTEN and by impeding ERbeta-dependent cyclin D1 promoter activity, which subsequently resulted in the transcription of the estrogen-responsive element remaining unchanged.	Quercetin	17-26	cyclin D1	Homo sapiens	142-151
22677435-10	2012	The expression of CCND1, CCND2 and CDK6 was suppressed by miR-16 in hMSCs.	mir-16	58-64	cyclin D1	Homo sapiens	18-23
22709873-11	2012	Additionally, Cyclin D1 (CCND1), a common regulator of the other four proteins, was also demonstrated to observe a proportional response to lapatinib exposure.	Lapatinib	140-149	cyclin D1	Homo sapiens	14-23
22709873-11	2012	Additionally, Cyclin D1 (CCND1), a common regulator of the other four proteins, was also demonstrated to observe a proportional response to lapatinib exposure.	Lapatinib	140-149	cyclin D1	Homo sapiens	25-30
22550166-7	2012	In contrast, the recruitment of the ERalpha/AIB1 transcriptional complex to the nonclassic ER target cyclin D1 and its subsequent expression remained sensitive to steroid treatment and could be inhibited by treatment with letrozole.	Steroids	163-170	cyclin D1	Homo sapiens	101-110
22550166-7	2012	In contrast, the recruitment of the ERalpha/AIB1 transcriptional complex to the nonclassic ER target cyclin D1 and its subsequent expression remained sensitive to steroid treatment and could be inhibited by treatment with letrozole.	Letrozole	222-231	cyclin D1	Homo sapiens	101-110
22550166-8	2012	Molecular studies revealed that this may be due in part to direct steroid regulation of c-jun-NH(2)-kinase (JNK), signaling to Jun and Fos at the cyclin D1 promoter.	Steroids	66-73	cyclin D1	Homo sapiens	146-155
22231280-5	2012	Here we show that single-agent bortezomib treatment of MCL cell lines leads to G2/M arrest and induction of apoptosis accompanied by downregulation of EIF4E and CCND1 mRNA but upregulation of p15(INK4B) and p21 mRNA.	Bortezomib	31-41	cyclin D1	Homo sapiens	161-166
22224416-9	2012	In addition, ATP enhanced the progression of cells from the G0/G1 phase to the S phase by increasing the expression of proteins for cyclin D1 and cyclin E. Silencing the P2X(4/7)  and P2Y(2)  receptors with siRNA targeting the corresponding receptor diminished ATP-stimulated proliferation and migration of the cardiac fibroblasts.	Adenosine Triphosphate	13-16	cyclin D1	Homo sapiens	132-141
22224416-9	2012	In addition, ATP enhanced the progression of cells from the G0/G1 phase to the S phase by increasing the expression of proteins for cyclin D1 and cyclin E. Silencing the P2X(4/7)  and P2Y(2)  receptors with siRNA targeting the corresponding receptor diminished ATP-stimulated proliferation and migration of the cardiac fibroblasts.	Adenosine Triphosphate	261-264	cyclin D1	Homo sapiens	132-141
21792888-8	2012	Sunitinib alone or in combination suppressed cyclin-D1 expression with the combination showing greater dose-dependent effect.	Sunitinib	0-9	cyclin D1	Homo sapiens	45-54
22451658-0	2012	Overexpression of hyaluronan-binding protein 1 (HABP1/p32/gC1qR) in HepG2 cells leads to increased hyaluronan synthesis and cell proliferation by up-regulation of cyclin D1 in AKT-dependent pathway.	Hyaluronic Acid	18-28	cyclin D1	Homo sapiens	163-172
22426690-8	2012	Irbesartan also significantly altered p53, PCNA and cyclin D1 expression, which was also influenced by activated AT1R in AT1R(+)-MCF-7 cells.	Irbesartan	0-10	cyclin D1	Homo sapiens	52-61
22389381-6	2012	We found that metformin inhibited growth and decreased expression of cyclin D1 in MTC cells.	Metformin	14-23	cyclin D1	Homo sapiens	69-78
22262839-6	2012	We conclude that in the serum-stimulated human vascular smooth muscle primary cell cultures, bilirubin favors growth arrest, and we propose that this activity is regulated by its interaction with the Raf/ERK/MAPK pathway, effect on cyclin D1 and Raf content, altered retinoblastoma protein profile of hypophosphorylation, calcium influx, and YY1 proteolysis.	Bilirubin	93-102	cyclin D1	Homo sapiens	232-241
22383427-4	2012	(3)H-thymidine incorporation assays revealed that sorafenib causes a dose-dependent inhibition of proliferation of all cell lines associated with downregulation of cyclin-dependent kinase 2 and cyclin D1 expression.	Sorafenib	50-59	cyclin D1	Homo sapiens	194-203
22678010-11	2012	Cyclin D1 mRNA and protein concentrations in serum-stimulated podocytes were reduced after blocking ERK activation by U0126.	U 0126	118-123	cyclin D1	Homo sapiens	0-9
22366652-14	2012	The selective inhibition of cancer cell growth, the apoptosis induction via the mitochondrial pathway, and the G0/G1 arrest by modulating the PI3K/AKT signaling pathway and downregulating cyclin D1, which leads to the release of p27kip1 and the association of this inhibitor with the cyclin E/CDK2 complex, ultimately preventing cell-cycle progression from G1 to S phase, all serve to provide support for further studies of tehranolide as a possible anticancer drug in the clinical treatment of cancer.	tehranolide	424-435	cyclin D1	Homo sapiens	188-197
22307313-0	2012	Treatment with bisphenol A and methoxychlor results in the growth of             human breast cancer cells and alteration of the expression of cell cycle-related             genes, cyclin D1 and p21, via an estrogen receptor-dependent signaling pathway.	bisphenol A	15-26	cyclin D1	Homo sapiens	181-190
22307313-0	2012	Treatment with bisphenol A and methoxychlor results in the growth of             human breast cancer cells and alteration of the expression of cell cycle-related             genes, cyclin D1 and p21, via an estrogen receptor-dependent signaling pathway.	Methoxychlor	31-43	cyclin D1	Homo sapiens	181-190
21997969-4	2012	Tanshinone IIA induced cell cycle arrest at G1 phase and down-regulated cyclin D1, CDK2 and CDK4.	tanshinone	0-10	cyclin D1	Homo sapiens	72-81
21997969-7	2012	Conversely, silencing p53 using its specific siRNA reversed cyclin D1 expression inhibited by tanshinone IIA.	tanshinone	94-108	cyclin D1	Homo sapiens	60-69
22502866-6	2012	Using Cyclin D1 as a test case, we demonstrated that enhanced usage of proximal CSs compromises microRNA-mediated repression.	thiocysteine	80-83	cyclin D1	Homo sapiens	6-15
22517885-8	2012	F5-P-mediated delivery of a cocktail of PLK1, CCND1, and AKT siRNAs was more effective than an equivalent dose of PLK1-siRNAs alone.	f5-p	0-4	cyclin D1	Homo sapiens	46-51
22351689-9	2012	Although response to RAF265 did not correlate with pERK1/2 reduction, RAF265 responders did exhibit reduced pMEK1, reduced proliferation based upon reduced Ki-67, cyclin D1 and polo-like kinase1 levels, and induction of the apoptosis mediator BCL2-like 11.	RAF265	70-76	cyclin D1	Homo sapiens	163-194
22450442-4	2012	Pycnidione significantly decreased the expression of cyclins D1 and E and induced G(1)-phase cell cycle arrest and a subsequent increase in the sub-G(1) phase population.	pycnidione	0-10	cyclin D1	Homo sapiens	53-69
22475046-2	2012	CCND1 amplification and protein overexpression have also been associated with resistance to treatment with tamoxifen or even to a potentially detrimental effect of tamoxifen.	Tamoxifen	107-116	cyclin D1	Homo sapiens	0-5
22475046-2	2012	CCND1 amplification and protein overexpression have also been associated with resistance to treatment with tamoxifen or even to a potentially detrimental effect of tamoxifen.	Tamoxifen	164-173	cyclin D1	Homo sapiens	0-5
22475046-9	2012	CONCLUSIONS: In summary, CCND1 amplification and low nuclear expression of cyclin D1 predicted poor clinical outcome in postmenopausal breast cancer patients treated with either anastrozole or tamoxifen.	Anastrozole	178-189	cyclin D1	Homo sapiens	25-30
22475046-9	2012	CONCLUSIONS: In summary, CCND1 amplification and low nuclear expression of cyclin D1 predicted poor clinical outcome in postmenopausal breast cancer patients treated with either anastrozole or tamoxifen.	Anastrozole	178-189	cyclin D1	Homo sapiens	75-84
22475046-9	2012	CONCLUSIONS: In summary, CCND1 amplification and low nuclear expression of cyclin D1 predicted poor clinical outcome in postmenopausal breast cancer patients treated with either anastrozole or tamoxifen.	Tamoxifen	193-202	cyclin D1	Homo sapiens	25-30
22475046-9	2012	CONCLUSIONS: In summary, CCND1 amplification and low nuclear expression of cyclin D1 predicted poor clinical outcome in postmenopausal breast cancer patients treated with either anastrozole or tamoxifen.	Tamoxifen	193-202	cyclin D1	Homo sapiens	75-84
22343378-7	2012	ATP synthesis inhibitor-oligomycin-treatment suppressed the cyclin D1 and cyclin B1 expression levels and blocked cell cycle progression.	Oligomycins	24-34	cyclin D1	Homo sapiens	60-69
22185819-4	2012	Concurrent with the cell cycle arrest of MCF7 cells, artemisinin selectively downregulated the transcript and protein levels of the CDK2 and CDK4 cyclin-dependent kinases, cyclin E, cyclin D1, and the E2F1 transcription factor.	artemisinin	53-64	cyclin D1	Homo sapiens	182-191
21989330-0	2012	The Cyclin D1 (CCND1) A870G polymorphism predicts clinical outcome to lapatinib and capecitabine in HER2-positive metastatic breast cancer.	Lapatinib	70-79	cyclin D1	Homo sapiens	15-20
21989330-0	2012	The Cyclin D1 (CCND1) A870G polymorphism predicts clinical outcome to lapatinib and capecitabine in HER2-positive metastatic breast cancer.	Capecitabine	84-96	cyclin D1	Homo sapiens	4-13
21989330-0	2012	The Cyclin D1 (CCND1) A870G polymorphism predicts clinical outcome to lapatinib and capecitabine in HER2-positive metastatic breast cancer.	Capecitabine	84-96	cyclin D1	Homo sapiens	15-20
22266527-13	2012	The low doses of dietary genistein abrogated the inhibitory effect of tamoxifen potentially by acting on the tumor cell proliferation/apoptosis ratio and the messenger RNA (mRNA) expression of cyclin D1 in addition to regulating the mRNA expression of progesterone receptor.	Genistein	25-34	cyclin D1	Homo sapiens	193-202
22425181-5	2012	Lobaplatin treatment reduced Cyclin D1, CDK4, and CDK6 expression, which led to the blocking of G0/G1 transition.	lobaplatin	0-10	cyclin D1	Homo sapiens	29-38
22085492-3	2012	In this paper we found that LCH-7749944, a novel and potent PAK4 inhibitor, effectively suppressed the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway.	lithocholyl-N-hydroxysuccinimide	28-31	cyclin D1	Homo sapiens	189-198
22266527-13	2012	The low doses of dietary genistein abrogated the inhibitory effect of tamoxifen potentially by acting on the tumor cell proliferation/apoptosis ratio and the messenger RNA (mRNA) expression of cyclin D1 in addition to regulating the mRNA expression of progesterone receptor.	Tamoxifen	70-79	cyclin D1	Homo sapiens	193-202
22369110-0	2012	Rapid downregulation of cyclin D1 induced by geranylgeranoic acid in human hepatoma cells.	geranylgeranic acid	45-65	cyclin D1	Homo sapiens	24-33
22311672-3	2012	Particularly, IFN-alpha enhances RA-mediated G(0)-G(1) cell accumulation by downregulating cyclin D1 and increasing p27(Kip1) and p21(WAF1/Cip1) protein levels.	Alitretinoin	33-35	cyclin D1	Homo sapiens	91-100
22234583-5	2012	Our findings demonstrate that resveratrol down-regulates the protein cyclin D1 and, in a concentration dependent manner, the phosphorylation levels of protein kinase B (Akt) and glycogen synthase kinase-3beta (GSK-3beta).	Resveratrol	30-41	cyclin D1	Homo sapiens	69-78
22389471-7	2012	The combination of GSK2118436 and GSK1120212 effectively inhibited cell growth, decreased ERK phosphorylation, decreased cyclin D1 protein, and increased p27(kip1) protein in the resistant clones.	dabrafenib	19-29	cyclin D1	Homo sapiens	121-130
22389471-7	2012	The combination of GSK2118436 and GSK1120212 effectively inhibited cell growth, decreased ERK phosphorylation, decreased cyclin D1 protein, and increased p27(kip1) protein in the resistant clones.	trametinib	34-44	cyclin D1	Homo sapiens	121-130
22369110-6	2012	This reduction was partially blocked by pretreatment with 26S proteasome inhibitor MG-132, indicating that proteasomal degradation was involved in GGA-induced disappearance of cyclin D1.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	83-89	cyclin D1	Homo sapiens	176-185
22369110-7	2012	A phosphorylation of retinoblastoma protein (RB) at serine 780, a target site of cyclin D1-dependent kinase 4, was rapidly decreased in GGA-treated HuH-7 cells.	Serine	52-58	cyclin D1	Homo sapiens	81-90
22313388-6	2012	Consistent with the increased Fas/CD95 expression, a drastic decrease in the Tyr705 phosphorylation of STAT3, a known negative regulator of Fas/CD95 transcription, was shown within 15 min in the EGCG-treated cells, leading to downregulation of the target gene products of STAT3, such as bcl-2, vascular endothelial growth factor (VEGF), mcl-1, and cyclin D1.	epigallocatechin gallate	195-199	cyclin D1	Homo sapiens	348-357
22470341-6	2012	Bilirubin-mediated inhibition of neointimal thickening was associated with a significant decrease in ERK activity and cyclin D1 and A protein expression, and an increase in p21 and p53 protein expression in injured blood vessels.	Bilirubin	0-9	cyclin D1	Homo sapiens	118-127
22310976-8	2012	MiR-135a-mediated JAK2 downregulation also reduced p-STAT3 activation and cyclin D1 and Bcl-xL protein expression.	mir-135a	0-8	cyclin D1	Homo sapiens	74-83
22553812-8	2012	There were fewer cyclin D1-positive FAs than PTCC (52% vs. 89%, respectively; P=0.003) and PTCFV (52% vs. 88%, respectively; P=0.023).	ammonium ferrous sulfate	36-39	cyclin D1	Homo sapiens	17-26
22553812-12	2012	In conclusion, cyclin D1 shows heterogeneity in distribution and intensity in benign and malignant thyroid tumors, which disqualifies it as a primary diagnostic marker in these tumors; however, it may be helpful in distinguishing FA from PTC, especially PTCFV.	ptcfv	254-259	cyclin D1	Homo sapiens	15-24
22211565-4	2012	CR2408 leads to fragmentation of cells and induces an accumulation in the subG1 phase accompanied with moderately decreased levels of cyclin D1 and cdk4 and strongly decreased levels of cdc25a, pRb and p53.	CR2408	0-6	cyclin D1	Homo sapiens	134-143
22310976-9	2012	This study suggests that miR-135a may function as a tumor suppressor via targeting JAK to repress p-STAT3 activation, reduce cyclin D1 and Bcl-xL expression and inhibit gastric cancer cell proliferation.	mir-135a	25-33	cyclin D1	Homo sapiens	125-134
22198215-9	2012	In addition, 5-ASA also significantly changed expression of the downstream targets Cox2, cyclin D1 and E-cadherin, correlating with ss-catenin status.	5-Aminosalicylic acid	13-18	cyclin D1	Homo sapiens	89-98
21191671-4	2012	After treatment, UA-induced apoptosis was accompanied by a significant decrease in CyclinD1/CDK4 expression, which can be regulated by FoxM1.	ursolic acid	17-19	cyclin D1	Homo sapiens	83-91
22266466-2	2012	Cyclin D1 level changes are partially controlled by GSK-3beta-dependent phosphorylation at threonine-286 (Thr286), which targets cyclin D1 for ubiquitination and proteolytic degradation.	Threonine	91-100	cyclin D1	Homo sapiens	0-9
22266466-2	2012	Cyclin D1 level changes are partially controlled by GSK-3beta-dependent phosphorylation at threonine-286 (Thr286), which targets cyclin D1 for ubiquitination and proteolytic degradation.	Threonine	91-100	cyclin D1	Homo sapiens	129-138
22266466-8	2012	NQO2 knockdown cells also showed attenuation of resveratrol-induced downregulation of cyclin D1.	Resveratrol	48-59	cyclin D1	Homo sapiens	86-95
22266466-9	2012	Our results indicate a hitherto unreported role of NQO2 in the control of AKT/GSK-3beta/cyclin D1 and highlight the involvement of NQO2 in degradation of cyclin D1, as part of mechanism of chemoprevention by resveratrol.	Resveratrol	208-219	cyclin D1	Homo sapiens	88-97
22266466-9	2012	Our results indicate a hitherto unreported role of NQO2 in the control of AKT/GSK-3beta/cyclin D1 and highlight the involvement of NQO2 in degradation of cyclin D1, as part of mechanism of chemoprevention by resveratrol.	Resveratrol	208-219	cyclin D1	Homo sapiens	154-163
22008998-7	2012	Furthermore, overexpression of Bcl-1 or c-FLIP(L) inhibited the cell death induced by the combined treatment with RU486 and TRAIL.	Mifepristone	114-119	cyclin D1	Homo sapiens	31-36
21191671-7	2012	Taken together, the data suggest that the proapoptotic effect of UA on MCF-7 cells is mediated by inhibition of FoxM1 and is highly correlated with inactivation of CyclinD1/CDK4.	ursolic acid	65-67	cyclin D1	Homo sapiens	164-172
22159450-5	2012	In particular SAHA downregulates cell             cycle-associated genes that modulate the G1/S transition (including cyclin D1             and cdc25a) and the G2/M transition [cyclin B1, Plk1, Stk6 (serine-threonine kinase             6, Aurora kinase A) and Kntc2] more significantly than CG-1521.	Vorinostat	14-18	cyclin D1	Homo sapiens	118-127
21656837-7	2012	Adenosine induced arrest in the cell-cycle progression in G0/G1 phase through Cdk4/cyclinD1-mediated pathway.	Adenosine	0-9	cyclin D1	Homo sapiens	83-91
22538871-2	2012	In a mammary gland specific Tet-inducible model the acute expression profile regulated by cyclin D1 after 7 days was enriched in genes that rank highly with CIN.	tetramethylenedisulfotetramine	28-31	cyclin D1	Homo sapiens	90-99
22116304-8	2012	L-Mimosine treatment decreased cyclin D1 protein in PC-3 cells, but not in LNCaP cells.	Mimosine	0-10	cyclin D1	Homo sapiens	31-40
22490843-3	2012	CyclinD1 genes and proteins were detected by reverse transcription-polymerase chain reaction (RT-PCR) and flow cytometry before and after the activation of cell 3AO by cis-platinum.	Cisplatin	168-180	cyclin D1	Homo sapiens	0-8
22336657-6	2012	Cyclin D1 protein overexpression was significantly associated with lymph node metastasis (P = 0.002), tumor cell differentiation (P = 0.031) and tumor stage (P = 0.051), but not associated with age onset, cigarette smoking, alcohol drinking, or areca quid chewing.	Alcohols	224-231	cyclin D1	Homo sapiens	0-9
22242598-12	2012	Consistent with these findings, induction of differentiation of HepG2 cells by 1% DMSO was accompanied by a reduction in the level of cyclin D1 expression and the appearance of hC/EBPbeta, hSNF2H, and hACF1 on the promoter region of this gene.	Dimethyl Sulfoxide	82-86	cyclin D1	Homo sapiens	134-143
22490843-6	2012	Under cis-platinum, different expressions of cyclinD1 genes were found in 3AO by RT-PCR.	Cisplatin	6-18	cyclin D1	Homo sapiens	45-53
22490843-7	2012	The higher the concentrations of cisplatin, the lower expressions of cyclinD1 genes.	Cisplatin	33-42	cyclin D1	Homo sapiens	69-77
22490843-8	2012	By flow cytometry, it was also found that there were lower expressions of cyclinD1 protein in 3AO under cisplatin than without it.	Cisplatin	104-113	cyclin D1	Homo sapiens	74-82
22490843-9	2012	With the rising concentrations of cisplatin, the low expressions of cyclinD1 protein in 3AO were detected.	Cisplatin	34-43	cyclin D1	Homo sapiens	68-76
22490843-13	2012	A positive correlation is found between the lower expressions of cyclinD1 and the concentration of cisplatin.	Cisplatin	99-108	cyclin D1	Homo sapiens	65-73
22260668-4	2012	Selumetinib-resistant cells were refractory to other MEK1/2 inhibitors in cell proliferation assays and exhibited a marked increase in MEK1/2 and ERK1/2 activity and cyclin D1 abundance when assessed in the absence of inhibitor.	AZD 6244	0-11	cyclin D1	Homo sapiens	166-175
22142990-11	2012	Western blot analysis showed that in U373 cells the content of PR isoforms (PR-A and PR-B), EGFR, VEGF and cyclin D1 increased after PPT treatment while in D54 cells only the content of EGFR was increased.	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	133-136	cyclin D1	Homo sapiens	107-116
22244892-6	2012	Sal generally reduced cyclin D1 levels in PAC-, DOC-, and VIN-treated cells.	sal	0-3	cyclin D1	Homo sapiens	22-31
21400508-5	2012	Mechanistically, we showed that LBH589 not only affected the expression of p21 and cyclin D1, but markedly determined microtubule stabilization as evidenced by tubulin acetylation and increased tubulin polymerization.	Panobinostat	32-38	cyclin D1	Homo sapiens	83-92
22210317-4	2012	Adult cadaveric islets were transduced with doxycycline (Dox)-inducible adenoviruses expressing cdk6 or cyclin D1.	Doxycycline	44-55	cyclin D1	Homo sapiens	104-113
22210317-4	2012	Adult cadaveric islets were transduced with doxycycline (Dox)-inducible adenoviruses expressing cdk6 or cyclin D1.	Doxycycline	57-60	cyclin D1	Homo sapiens	104-113
22210317-6	2012	Increasing doses of Dox led to marked dose- and time-related increases in cdk6 and cyclin D1, accompanied by a 20-fold increase in beta-cell proliferation.	Doxycycline	20-23	cyclin D1	Homo sapiens	83-92
22210317-7	2012	Notably, Dox withdrawal resulted in a reversal of both cdk6 and cyclin D1 expression as well as beta-cell proliferation.	Doxycycline	9-12	cyclin D1	Homo sapiens	64-73
21448924-8	2012	We show that high levels of glucose regulate mRNA and protein expression of GSK3beta, and consequently higher levels of activated beta-catenin protein, which locates to the nucleus and is associated with increased levels of cyclin D1 expression.	Glucose	28-35	cyclin D1	Homo sapiens	224-233
21559876-4	2012	Simultaneously, Western blots showed that VRAC inhibition led to a decrease in CDK 4 and cyclin D1 expression accompanied with an increase in p27 expression, which caused the proliferating astrocytes arrested at the G1/S checkpoint.	vrac	42-46	cyclin D1	Homo sapiens	89-98
22191389-5	2012	RESULTS: Exposure to nanomolar concentrations of Sunitinib significantly reduced cell viability in only TPC-1 cells, and this effect was paralleled by reduction of cyclin D1 levels.	Sunitinib	49-58	cyclin D1	Homo sapiens	164-173
22180308-4	2012	Dovitinib downregulated phospho-STAT3 (p-STAT3) at tyrosine 705 and subsequently reduced the levels of expression of STAT3-related proteins Mcl-1, survivin, and cyclin D1 in a time-dependent manner.	4-amino-5-fluoro-3-(5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl)quinolin-2(1H)-one	0-9	cyclin D1	Homo sapiens	161-170
22203730-5	2012	Furthermore, nitidine chloride suppressed the constitutively activated STAT3 protein, its DNA-binding activity, and the expression of STAT3-dependent target genes, including cyclin D1, Bcl-xL, and VEGF in human gastric cancer cells.	nitidine	13-30	cyclin D1	Homo sapiens	174-183
21993902-9	2012	The data presented an increase of G0/G1 phase cells and decrease of S phase cells             after rapamycin treatment, and the decreased expression of cyclinD1, higher expression             of p21 at mRNA level was also detected in K562 with rapamycin.	Sirolimus	245-254	cyclin D1	Homo sapiens	153-161
22949827-0	2012	Effects of cyclooxygenase inhibitors in combination with taxol on expression of cyclin D1 and Ki-67 in a xenograft model of ovarian carcinoma.	Paclitaxel	57-62	cyclin D1	Homo sapiens	80-89
22213296-2	2012	MATERIALS AND METHODS: Cyclin D1 was silenced in an HNSCC cell line and its effect tested in sensitizing the cells to cisplatin, in vitro as well as in vivo.	Cisplatin	118-127	cyclin D1	Homo sapiens	23-32
22213296-5	2012	RESULTS: Stable silencing of cyclin D1 resulted in delayed cell cycle progression and significantly sensitized the cells to cisplatin.	Cisplatin	124-133	cyclin D1	Homo sapiens	29-38
21399894-8	2012	Quantitative PCR and western analysis confirmed decreased expression of two genes, BCL-2 and CCND1, in docetaxel-resistant cells, which are both targeted by miR-34a.	Docetaxel	103-112	cyclin D1	Homo sapiens	93-98
21399894-12	2012	This serves as a mechanism of acquired docetaxel resistance in these cells, possibly through direct interactions with BCL-2 and CCND1, therefore presenting a potential therapeutic target for the treatment of docetaxel-resistant breast cancer.	Docetaxel	39-48	cyclin D1	Homo sapiens	128-133
21399894-12	2012	This serves as a mechanism of acquired docetaxel resistance in these cells, possibly through direct interactions with BCL-2 and CCND1, therefore presenting a potential therapeutic target for the treatment of docetaxel-resistant breast cancer.	Docetaxel	208-217	cyclin D1	Homo sapiens	128-133
22052462-5	2012	Treatment with the CXCR4 antagonist AMD3100 inhibited cyclin D1 expression and maximal tumor growth in vivo.	plerixafor	36-43	cyclin D1	Homo sapiens	54-63
22358238-9	2012	Incubation with gamma-tocotrienol decreased CCND1 and RB1 expression in senescent fibroblasts, decreased cell populations in the G(0)/G(1) phase and increased cell populations in the G(2)/M phase.	plastochromanol 8	16-33	cyclin D1	Homo sapiens	44-49
22654912-5	2012	Such drug treatment also reverses estradiol-induced upregulation of c-Myc, cyclinD1, and P21(Cip), gene products involved in cell proliferation.	Estradiol	34-43	cyclin D1	Homo sapiens	75-83
22489120-4	2012	Analysis of Western blot showed that (R,R)ZX-5 up-regulated the expression of Akt, p-Akt (Thr473), eNOS and p-eNOS (Ser1177), down-regulated the expression of Cyclin D1 in human retinal endothelial cells and escalated the intracellular free Ca(2+) concentration.	(r,r)zx-5	37-46	cyclin D1	Homo sapiens	159-168
21893403-8	2012	The mechanism of maslinic acid-induced cell cycle arrest may be mediated by inhibiting cyclin D1 expression and enhancing the levels of cell cycle-dependent kinase (CDK) inhibitor p21 protein.	maslinic acid	17-30	cyclin D1	Homo sapiens	87-96
22213296-7	2012	CONCLUSION: Suboptimal concentrations of cisplatin could be used in vivo to eradicate xenograft tumors indicating the promise of combining vector-based cyclin D1 silencing with chemotherapy to achieve maximum tumor regression.	Cisplatin	41-50	cyclin D1	Homo sapiens	152-161
23123471-3	2012	Gomisin A significantly inhibited cell proliferation in a dose-dependent manner after 72 h treatment, especially in the presence of tumor necrosis factor-alpha (TNF-alpha), due to cell cycle arrest in the G1 phase with the downregulation of cyclin D1 expression and Retinoblastoma (RB) phosphorylation.	schizandrol B	0-9	cyclin D1	Homo sapiens	241-250
23123471-5	2012	Inhibition of STAT1 pathways by a small-interfering RNA against STAT1 and AG490 Janus kinase (JAK) kinase inhibitor AG490 reduced the cyclin D1 expression and RB phosphorylation, indicating that JAK-mediated STAT1 activation is involved in gomisin A-induced G1 cell cycle arrest.	schizandrol B	240-249	cyclin D1	Homo sapiens	134-143
23568006-1	2012	AIM: To investigate whether the inhibition of Bcl-2 and Cyclin D1 by lentivirus-mediated RNA interference enhances doxorubicin (DXR) cytotoxicity in the drug-resistant human osteosarcoma MG63 cells.	Doxorubicin	128-131	cyclin D1	Homo sapiens	56-65
22854281-10	2012	The protein expressions of p-cyclin D1, total cyclin D1, p-CDK2, total CDK2, p-Rb, total Rb, Bcl-xL, and Akt were significantly inhibited by furanodiene, whereas the protein expressions of Bad and Bax, and the proteolytic cleavage of caspase-9, caspase-7, and poly-ADP-ribose polymerase (PARP) were dramatically increased.	furanodiene	141-152	cyclin D1	Homo sapiens	29-38
22854281-10	2012	The protein expressions of p-cyclin D1, total cyclin D1, p-CDK2, total CDK2, p-Rb, total Rb, Bcl-xL, and Akt were significantly inhibited by furanodiene, whereas the protein expressions of Bad and Bax, and the proteolytic cleavage of caspase-9, caspase-7, and poly-ADP-ribose polymerase (PARP) were dramatically increased.	furanodiene	141-152	cyclin D1	Homo sapiens	46-55
23006739-7	2012	The combination of GDC-0941 and rapamycin downregulated the key components of the cell cycle machinery, such as cyclin D1 and upregulated the apoptotic markers.	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	19-27	cyclin D1	Homo sapiens	112-121
22949827-1	2012	The present study was designed to investigate the effects of cyclooxygenase (COX) inhibitors in combination with taxol on the expression of cyclin D1 and Ki-67 in human ovarian SKOV-3 carcinoma cells xenograft-bearing mice.	Paclitaxel	113-118	cyclin D1	Homo sapiens	140-149
22500182-2	2012	We examined the antiproliferative effectiveness of the corticosteroid dexamethasone on expression of the key regulator of G(1) cell cycle progression-cyclin D1-in ASM cells from nonasthmatics and asthmatics stimulated with the mitogen platelet-derived growth factor BB.	Dexamethasone	70-83	cyclin D1	Homo sapiens	150-159
23320178-5	2012	Since cyclin D1 is a major regulator of cell cycle, we further studied the effects of auraptene on cell cycle and the genes related to cell cycle in MCF-7 cells.	aurapten	86-95	cyclin D1	Homo sapiens	6-15
22500182-3	2012	While cyclin D1 mRNA and protein expression were repressed in cells from nonasthmatics in contrast, cyclin D1 expression in asthmatics was resistant to inhibition by dexamethasone.	Dexamethasone	166-179	cyclin D1	Homo sapiens	100-109
23093837-6	2012	RESULTS: VPA treatment causes cell cycle arrest in PCa cells in vivo, as determined by increase in p21 and p27 and decrease in cyclin D1 expression.	Valproic Acid	9-12	cyclin D1	Homo sapiens	127-136
23233819-7	2012	Particularly with Gemzar, ectopic expression of cyclinD1 protein in MCF7 cells results in a potentiated effect, which is CDK4 kinase activity dependent, whereas in MB231 cells, an opposite effect was observed.	gemcitabine	18-24	cyclin D1	Homo sapiens	48-56
21879332-3	2012	In this study, we found that gambogenic acid (GNA), a polyprenylated xanthone isolated from the traditional medicine gamboge, efficiently arrested the cell cycle at the G(0)/G(1) phase by specifically repressing the expression of cyclin D1 and cyclin E, suppressed cell proliferation, colony formation and cell migration, and induced caspase-dependent apoptosis in U251 glioblastoma cells in a time- and dose-dependent manner.	neo-gambogic acid	29-44	cyclin D1	Homo sapiens	230-239
21879332-3	2012	In this study, we found that gambogenic acid (GNA), a polyprenylated xanthone isolated from the traditional medicine gamboge, efficiently arrested the cell cycle at the G(0)/G(1) phase by specifically repressing the expression of cyclin D1 and cyclin E, suppressed cell proliferation, colony formation and cell migration, and induced caspase-dependent apoptosis in U251 glioblastoma cells in a time- and dose-dependent manner.	neo-gambogic acid	46-49	cyclin D1	Homo sapiens	230-239
22570653-4	2012	3-Cl-AHPC-induced apoptosis was preceded by decreasing expression of IGF-1R, cyclin D1, beta-catenin, and activated Notch-1 in the pancreatic cancer cell lines.	4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid	0-9	cyclin D1	Homo sapiens	77-86
22150677-10	2012	CONCLUSIONS: Downregulation of the mRNA levels of CDK2, CDK4 and cyclin D1 and upregulation of p21 might be a possible mechanism for the inhibition of proliferation induced by alteronol in HeLa cells.	alteronol	176-185	cyclin D1	Homo sapiens	65-74
22098108-8	2012	However, genistein treatment greatly attenuated IGF-1-induced beta-catenin signaling that correlated with increasing the levels of E-cadherin and decreasing cyclin D1 levels in PC-3 cells.	Genistein	9-18	cyclin D1	Homo sapiens	157-166
22919439-0	2012	Coffee polyphenols change the expression of STAT5B and ATF-2 modifying cyclin D1 levels in cancer cells.	coffee polyphenols	0-18	cyclin D1	Homo sapiens	71-80
22919439-9	2012	CONCLUSIONS: Coffee polyphenols are able to affect cyclin D1 expression in cancer cells through the modulation of STAT5B and ATF-2.	coffee polyphenols	13-31	cyclin D1	Homo sapiens	51-60
22149883-10	2012	Consistent with STAT3 inactivation, H-geniposide downregulated the expressions of Bcl-2, Bcl-xL, survivin, and cyclin D1; this correlated with the accumulation of cells in the sub-G1 phase of the cell cycle and the induction of apoptosis.	h-geniposide	36-48	cyclin D1	Homo sapiens	111-120
23300831-11	2012	Treatment of desferrioxamine, a HIF-1alpha activator, led to further downregulation of expressions of cyclin D1 and c-Myc in osteoblasts.	Deferoxamine	13-28	cyclin D1	Homo sapiens	102-111
23300886-7	2012	Pharmacological inhibition of JAK/STAT3, PI3K/Akt or MEK/ERK signaling by AG490, Wortmannin or U0126, respectively, reduced leptin-induced cyclin D1 expression and NP cell proliferation.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	74-79	cyclin D1	Homo sapiens	139-148
23300886-7	2012	Pharmacological inhibition of JAK/STAT3, PI3K/Akt or MEK/ERK signaling by AG490, Wortmannin or U0126, respectively, reduced leptin-induced cyclin D1 expression and NP cell proliferation.	Wortmannin	81-91	cyclin D1	Homo sapiens	139-148
23300886-7	2012	Pharmacological inhibition of JAK/STAT3, PI3K/Akt or MEK/ERK signaling by AG490, Wortmannin or U0126, respectively, reduced leptin-induced cyclin D1 expression and NP cell proliferation.	U 0126	95-100	cyclin D1	Homo sapiens	139-148
23226276-2	2012	Here, we report that Kaiso associates with and regulates the cyclin D1 promoter via the consensus Kaiso binding site (KBS), and also via methylated CpG-dinucleotides.	cytidylyl-3'-5'-guanosine	148-165	cyclin D1	Homo sapiens	61-70
23029074-15	2012	CONCLUSIONS/SIGNIFICANCE: Puerarin suppresses proliferation of ESCs induced by E(2)-BSA partly via impeding a rapid, non-genomic, membrane-initiated ERK pathway, and down-regulation of Cyclin D1, Cox-2 and Cyp19 are involved in the process.	puerarin	26-34	cyclin D1	Homo sapiens	185-194
22905217-4	2012	Mutation of SUMO acceptor lysines 159 and 279 located in the C-terminal repression domain has no impact on nuclear localization; however, it abrogates association with the co-repressor histone deacetylase 1 (HDAC1), attenuates repression of cyclin D1, and prevents Stra13-mediated growth suppression.	Lysine	26-33	cyclin D1	Homo sapiens	241-250
22911796-5	2012	Furthermore, we demonstrate that miR-133 inhibits mitotic progression by targeting Sp1, which mediates Cyclin D1 transcription, while miR-1 suppresses G1/S phase transition by targeting Cyclin D1.	mir-133	33-40	cyclin D1	Homo sapiens	103-112
22860097-10	2012	Latent effects of the p14ARF-induced cellular processes resulting from high nuclear cyclin D1 accumulation included a redistribution of Ki-67 into the nucleoli, aberrant nuclear growth (multinucleation), and cell proliferation.	ki-67	136-141	cyclin D1	Homo sapiens	84-93
22701710-8	2012	Cell cycle arrest in erlotinib-treated cells is associated with an inhibition of ERK and Akt signaling, resulting in cyclin D1 downregulation, an increase in p27(kip1) levels and pRB hypophosphorylation.	Erlotinib Hydrochloride	21-30	cyclin D1	Homo sapiens	117-126
22558078-11	2012	Combination of seliciclib with flavopiridol effectively reduced CCNE1 and CCND1 protein levels, increased subG1 apoptotic fraction and promoted MM cell death in BMSCs co-culture conditions, therefore over-coming stroma-mediated protection.	alvocidib	31-43	cyclin D1	Homo sapiens	74-79
22359572-4	2012	In this study, we demonstrated, for the first time, the anti-angiogenic mechanism of action of DHC to be via the induction of cell cycle progression at the G0/G1 phase due to abrogation of the Akt/glycogen synthase kinase-3beta (GSK-3beta)/cyclin D1 and mTOR signaling pathway.	dehydrocostus lactone	95-98	cyclin D1	Homo sapiens	240-249
22359572-6	2012	DHC caused G0/G1 cell cycle arrest, which was associated with the down-regulation of cyclin D1 expression, leading to the suppression of retinoblastoma protein phosphorylation and subsequent inhibition of cyclin A and cdk2 expression.	dehydrocostus lactone	0-3	cyclin D1	Homo sapiens	85-94
22359572-7	2012	With respect to the molecular mechanisms underlying the DHC-induced cyclin D1 down-regulation, this study demonstrated that DHC significantly inhibits Akt expression, resulting in the suppression of GSK-3beta phosphorylation and mTOR expression.	dehydrocostus lactone	56-59	cyclin D1	Homo sapiens	68-77
22359572-7	2012	With respect to the molecular mechanisms underlying the DHC-induced cyclin D1 down-regulation, this study demonstrated that DHC significantly inhibits Akt expression, resulting in the suppression of GSK-3beta phosphorylation and mTOR expression.	dehydrocostus lactone	124-127	cyclin D1	Homo sapiens	68-77
22363450-6	2012	Cell cycle analysis demonstrated that curcumin treatment induced cell death and down regulated cyclin D1 levels.	Curcumin	38-46	cyclin D1	Homo sapiens	95-104
22253748-9	2012	Enzastaurin-induced G1 arrest was associated with inhibition of Erk1/2 phosphorylation, downregulation of cyclin D1, and accumulation of cyclin dependent kinase inhibitor p27(Kip1).	enzastaurin	0-11	cyclin D1	Homo sapiens	106-115
21717457-5	2011	Both OSU03012 and PI103 downregulated phosphorylation of Akt and inhibited the downstream targets glycogen synthase kinase-3beta (GSK3beta) and p70 S6 kinase-1 (S6K1), as well as downregulated the expression of cyclin D1 and Mycn protein.	OSU 03012	5-13	cyclin D1	Homo sapiens	211-220
21864554-7	2011	Incubation of endothelial cells with DHEA for 5 min resulted in a 2-fold increase of cyclin D1 mRNA and protein expression at 4h.	Dehydroepiandrosterone	37-41	cyclin D1	Homo sapiens	85-94
21864554-11	2011	We conclude that H(2)O(2) is a key signaling molecule mediating the proliferative effects of DHEA in vascular endothelial cells, possibly by up-regulating cell-cycle associated genes, such as cyclin D1.	Hydrogen Peroxide	17-25	cyclin D1	Homo sapiens	192-201
21864554-11	2011	We conclude that H(2)O(2) is a key signaling molecule mediating the proliferative effects of DHEA in vascular endothelial cells, possibly by up-regulating cell-cycle associated genes, such as cyclin D1.	Dehydroepiandrosterone	93-97	cyclin D1	Homo sapiens	192-201
21431842-6	2011	RESULTS: Surgical specimens from COX-2 positive endometrial cancer patients treated with etodolac had significantly reduced expression levels of COX-2, Ki-67, p53, p21, p27, and cyclin D1 as determined by immunohistochemistry, while AI was not affected.	Etodolac	89-97	cyclin D1	Homo sapiens	178-187
22848779-7	2012	The level of cyclin D1 mRNA in K562 cells decreased after the treatment with TFA and calycosin.	Trifluoroacetic Acid	77-80	cyclin D1	Homo sapiens	13-22
22848779-7	2012	The level of cyclin D1 mRNA in K562 cells decreased after the treatment with TFA and calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	85-94	cyclin D1	Homo sapiens	13-22
21472727-6	2011	Deguelin-induced downregulation of proliferative (cyclin D1 and c-myc) and antiapoptotic proteins (Mcl-1, Bcl-xL and survivin) in prostate cancer cells culminated in the induction of apoptosis, inhibition of DNA synthesis and cell growth, altered membrane integrity, marked reduction of invasiveness, inhibition of anchorage-dependent and -independent colony formation.	deguelin	0-8	cyclin D1	Homo sapiens	50-59
21898528-0	2011	Bone marrow trephine biopsy findings in myeloma with small-lymphoid cells and CCND1 translocation.	trephine	12-20	cyclin D1	Homo sapiens	78-83
21757288-6	2011	Treatment of HER2-overexpressing ovarian cancer cells with magnolol down-regulated the HER2 downstream PI3K/Akt signaling pathway, and suppressed the expression of downstream target genes, vascular endothelial growth factor (VEGF), matrix metalloproteinase 2 (MMP2) and cyclin D1.	magnolol	59-67	cyclin D1	Homo sapiens	270-279
21292465-8	2011	In addition, gamma-tocotrienol inhibited angiogenesis in HUVECs by down-regulation of beta-catenin, cyclin D1, CD44, phospho-VEGFR-2 and MMP-9.	plastochromanol 8	13-30	cyclin D1	Homo sapiens	100-109
20571878-8	2011	For the most lapatinib-sensitive cell line (HK1-LMP1, with IC(50) ~ 600 nM), which harbored the highest levels of both EGFR and HER-2, inhibition of cell growth was associated G(0)/G(1) cell cycle arrest, marked PARP cleavage, caspase-3 cleavage, as well as significant downregulation of several important survival proteins (e.g. survivin, Mcl-1 and cyclin D1).	Lapatinib	13-22	cyclin D1	Homo sapiens	350-359
21681414-5	2011	Western blot analysis revealed the elevated expression of cyclin D1 induced by cis-9 trans-11 CLA treatment and the decreased expression of cyclin D1 by trans-10 cis-12 CLA treatment in NPCs.	cis-9, trans-11-conjugated linoleic acid	79-97	cyclin D1	Homo sapiens	58-67
22076037-1	2011	OBJECTIVE: To evaluate the expressions of p53, p21, and CCND1 in the peripheral blood lymphocytes of vinyl chloride monomer (VCM)-exposed workers and potential relationships with their exposures, polymorphisms, and chromosomal aberrations.	Vinyl Chloride	101-115	cyclin D1	Homo sapiens	56-61
21555162-2	2011	This study builds on prior work by examining the roles of cyclin D1, cyclin D3, and cyclin E in mediating erlotinib sensitivity or resistance.	Erlotinib Hydrochloride	106-115	cyclin D1	Homo sapiens	58-67
21153447-12	2011	If the gene expression data for cyclin D1, cyclin G2, cdk2, cdk6 and cdk inhibtor 2B were used, the overall FDG uptake as measured by the SUV could be predicted with r = 0.75.	Fluorodeoxyglucose F18	108-111	cyclin D1	Homo sapiens	32-41
21681414-5	2011	Western blot analysis revealed the elevated expression of cyclin D1 induced by cis-9 trans-11 CLA treatment and the decreased expression of cyclin D1 by trans-10 cis-12 CLA treatment in NPCs.	trans-10,cis-12-conjugated linoleic acid	153-172	cyclin D1	Homo sapiens	140-149
21681414-6	2011	Cyclin D1-siRNA transfection significantly inhibited the promotion of cell proliferation by cis-9 trans-11 CLA.	cis-9, trans-11-conjugated linoleic acid	92-110	cyclin D1	Homo sapiens	0-9
21681414-10	2011	The effect of cis-9 trans-11 CLA may be associated with the up-regulation of cyclin D1 expression.	cis-9, trans-11-conjugated linoleic acid	14-32	cyclin D1	Homo sapiens	77-86
22509550-0	2011	[Effects of sodium selenite on the expressions of beta-catenin and its target cyclin D1 in colorectal cancer cells HCT 116 and SW480].	Sodium Selenite	12-27	cyclin D1	Homo sapiens	78-87
22368866-5	2011	RT-PCR was used to determine the level of Cyclin D1 mRNA in K562 cells after treated with TFA and calycosin.	Trifluoroacetic Acid	90-93	cyclin D1	Homo sapiens	42-51
22368866-5	2011	RT-PCR was used to determine the level of Cyclin D1 mRNA in K562 cells after treated with TFA and calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	98-107	cyclin D1	Homo sapiens	42-51
22368866-8	2011	The level of Cyclin D1 mRNA in K562 cells decreased after treated with TFA and calycosin.	Trifluoroacetic Acid	71-74	cyclin D1	Homo sapiens	13-22
22509550-1	2011	OBJECTIVE: To explore the effects of sodium selenite on the expressions of beta-catenin and cyclin D1 in colorectal cancer cells HCT 116 and SW480.	Sodium Selenite	37-52	cyclin D1	Homo sapiens	92-101
22368866-8	2011	The level of Cyclin D1 mRNA in K562 cells decreased after treated with TFA and calycosin.	7,3'-dihydroxy-4'-methoxyisoflavone	79-88	cyclin D1	Homo sapiens	13-22
22509550-4	2011	Meanwhile, the impact of MG132 (a proteasome inhibitor) pretreatment on the expressions of beta-catenin and cyclin D1 was observed through Western blot analysis.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	25-30	cyclin D1	Homo sapiens	108-117
22368866-9	2011	CONCLUSION: TFA could inhibit the proliferation of K562 cells, and attribute to arrest them in the G0/G1 phase and decrease Cyclin D1 mRNA.	Trifluoroacetic Acid	12-15	cyclin D1	Homo sapiens	124-133
22509550-6	2011	RESULTS: Sodium selenite inhibited the expression of beta-catenin and transcription of its target such as cyclin D1.	Sodium Selenite	9-24	cyclin D1	Homo sapiens	106-115
22509550-9	2011	CONCLUSIONS: Sodium selenite can lower the expression levels of beta-catenin and its target cyclin D1, during which the proteasome-mediated degradative pathway may be involved.	Sodium Selenite	13-28	cyclin D1	Homo sapiens	92-101
22110187-0	2011	Targeting cyclin D1 in non-small cell lung cancer and mesothelioma cells by antisense oligonucleotides.	Oligonucleotides	86-102	cyclin D1	Homo sapiens	10-19
22110187-5	2011	Western blot analysis of cell lysate showed that ASO inhibited the de novo synthesis of CD1, CD3, and CDK2 in multiple cell lines.	Oligonucleotides, Antisense	49-52	cyclin D1	Homo sapiens	88-91
21546908-8	2011	Knockdown of hif2alpha, birc5a or birc5b reduced the expression of the cdk inhibitors p27/cdkn1b and p57/cdkn1c and increased ccnd1/cyclin D1 transcription in the surviving neural progenitor cells.	birc5a	24-30	cyclin D1	Homo sapiens	126-131
22024062-5	2011	Additionally, positive correlations of ss-catenin with cyclinD1 and c-myc (r=0.412, p=0.002; r=0.447, p=0.000) and of p53 with bcl-2 (r=0.332, p=0.001) were found.	ss-catenin	39-49	cyclin D1	Homo sapiens	55-63
21785828-0	2011	The flavonoid Baohuoside-I inhibits cell growth and downregulates survivin and cyclin D1 expression in esophageal carcinoma via beta-catenin-dependent signaling.	Flavonoids	4-13	cyclin D1	Homo sapiens	79-88
21785828-0	2011	The flavonoid Baohuoside-I inhibits cell growth and downregulates survivin and cyclin D1 expression in esophageal carcinoma via beta-catenin-dependent signaling.	baohuoside I	14-26	cyclin D1	Homo sapiens	79-88
22357515-1	2011	OBJECTIVE: To investigate the roles of cyclin D1 and CDK4 in the cell cycle changes of human embryonic lung fibroblasts (HELFs) exposed to silica.	Silicon Dioxide	139-145	cyclin D1	Homo sapiens	39-48
22357515-6	2011	When suppressing the expression of cyclin D1 or CDK4, the proportions of cells in G1 phase in anti-D1 plus silica group and anti-K4 plus silica group did not obviously change, as compared with control group.	Silicon Dioxide	107-113	cyclin D1	Homo sapiens	35-44
22357515-6	2011	When suppressing the expression of cyclin D1 or CDK4, the proportions of cells in G1 phase in anti-D1 plus silica group and anti-K4 plus silica group did not obviously change, as compared with control group.	Silicon Dioxide	137-143	cyclin D1	Homo sapiens	35-44
22357515-7	2011	When suppressing AP-1 activity, the cyclin D1 and CDK4 expression levels decreased and the E2F-4 expression level increased in curcumin plus silica group, as compared with silica group.	Curcumin	127-135	cyclin D1	Homo sapiens	36-45
22357515-8	2011	CONCLUSION: The results of present suggested that 200 microg/ml silica could induce the high expression of cyclin D1 and CDK4 and the low expression of E2F-4, resulting in the cell cycle changes by AP-1/cyclin D1 pathway in HELFs.	Silicon Dioxide	64-70	cyclin D1	Homo sapiens	107-116
22357515-8	2011	CONCLUSION: The results of present suggested that 200 microg/ml silica could induce the high expression of cyclin D1 and CDK4 and the low expression of E2F-4, resulting in the cell cycle changes by AP-1/cyclin D1 pathway in HELFs.	Silicon Dioxide	64-70	cyclin D1	Homo sapiens	203-212
21872580-6	2011	Furthermore, the MDQ-induced G(0)/G(1) arrest was correlated with an increase in p27 and a decrease in cyclin D1 and p53.	mdq	17-20	cyclin D1	Homo sapiens	103-112
21726611-0	2011	Up-regulation of cyclin D1 by JNK1/c-Jun is involved in tumorigenesis of human embryo lung fibroblast cells induced by a low concentration of arsenite.	arsenite	142-150	cyclin D1	Homo sapiens	17-26
21726611-6	2011	Moreover, arsenite activates the JNK1/c-Jun signal pathway, but not JNK2, which up-regulates the expression of cyclin D1/CDK4 and phosphorylates the retinoblastoma (Rb) protein.	arsenite	10-18	cyclin D1	Homo sapiens	111-120
21726611-7	2011	Blocking of the JNK1/c-Jun signal pathway suppresses the increases of cyclin D1 expression and Rb phosphorylation, which attenuates cell proliferation, reduces the transition from the G1 to the S phase, and thereby inhibits the neoplastic transformation of HELF cells induced by a low concentration of arsenite.	arsenite	302-310	cyclin D1	Homo sapiens	70-79
21726611-8	2011	Thus, activation of the JNK1/c-Jun pathway up-regulates the expression of cyclin D1, which is involved in the tumorigenesis caused by a low concentration of arsenite.	arsenite	157-165	cyclin D1	Homo sapiens	74-83
21801719-10	2011	Reduced OS was (ADD) associated with cyclin D1 and cyclin A, grade, stage and metastasis (p=0.001, p=0.02, p=0.018, p=0.01, p=0.001).	Osmium	8-10	cyclin D1	Homo sapiens	37-46
21801719-12	2011	Cyclin D1 and cyclin A are prognostic biomarkers associated with reduced OS in HCC.	Osmium	73-75	cyclin D1	Homo sapiens	0-9
21721879-6	2011	Increasing the concentration of aspirin resulted in decreased expression of c-myc, cyclin D1, and fra-1 mRNA and protein in U87 and A172 cells in a dose-dependent manner.	Aspirin	32-39	cyclin D1	Homo sapiens	83-92
21737572-0	2011	The selective estrogen receptor modulator bazedoxifene inhibits hormone-independent breast cancer cell growth and down-regulates estrogen receptor alpha and cyclin D1.	bazedoxifene	42-54	cyclin D1	Homo sapiens	157-166
22028615-7	2011	WHSC1 interacts with some proteins related to the WNT pathway including beta-catenin and transcriptionally regulates CCND1, the target gene of the beta-catenin/Tcf-4 complex, through histone H3 at lysine 36 trimethylation.	Lysine	197-203	cyclin D1	Homo sapiens	117-122
21723923-4	2011	The mRNA and protein expressions of cyclin D1 increased with DHPG treatment and decreased after siRNA or MPEP treatment.	MPEP	105-109	cyclin D1	Homo sapiens	36-45
21951911-2	2011	N-(4-hydroxy phenyl) retinamide (4-HPR or fenretinide) is a potential chemotherapeutic for RTs with activity correlated to its ability to down-modulate Cyclin D1.	Fenretinide	0-31	cyclin D1	Homo sapiens	152-161
21951911-2	2011	N-(4-hydroxy phenyl) retinamide (4-HPR or fenretinide) is a potential chemotherapeutic for RTs with activity correlated to its ability to down-modulate Cyclin D1.	Fenretinide	42-53	cyclin D1	Homo sapiens	152-161
21951911-14	2011	CONCLUSIONS: Here we demonstrate, for the first time, that the inhibitory activities of novel halogen-substituted and peptidomimetic derivatives of 4-HPR are correlated to their ability to induce cell death and down-modulate Cyclin D1.	Halogens	94-101	cyclin D1	Homo sapiens	225-234
21868515-0	2011	Clioquinol suppresses cyclin D1 gene expression through transcriptional and post-transcriptional mechanisms.	Clioquinol	0-10	cyclin D1	Homo sapiens	22-31
21868515-2	2011	This study investigated the effects of clioquinol on cyclin D1 gene expression in breast cancer cells.	Clioquinol	39-49	cyclin D1	Homo sapiens	53-62
21868515-3	2011	Treatment with clioquinol significantly reduced cyclin D1 protein levels in a concentration-dependent manner, effects being more pronounced in the presence of zinc.	Clioquinol	15-25	cyclin D1	Homo sapiens	48-57
21868515-4	2011	Clioquinol reduced cyclin D1 mRNA contents in cells that had been pre-treated with actinomycin D, indicating that this compound alters cyclin D1 mRNA stability, an event associated with post-transcriptional regulation.	Clioquinol	0-10	cyclin D1	Homo sapiens	19-28
21868515-4	2011	Clioquinol reduced cyclin D1 mRNA contents in cells that had been pre-treated with actinomycin D, indicating that this compound alters cyclin D1 mRNA stability, an event associated with post-transcriptional regulation.	Clioquinol	0-10	cyclin D1	Homo sapiens	135-144
21868515-4	2011	Clioquinol reduced cyclin D1 mRNA contents in cells that had been pre-treated with actinomycin D, indicating that this compound alters cyclin D1 mRNA stability, an event associated with post-transcriptional regulation.	Dactinomycin	83-96	cyclin D1	Homo sapiens	19-28
21868515-4	2011	Clioquinol reduced cyclin D1 mRNA contents in cells that had been pre-treated with actinomycin D, indicating that this compound alters cyclin D1 mRNA stability, an event associated with post-transcriptional regulation.	Dactinomycin	83-96	cyclin D1	Homo sapiens	135-144
21868515-5	2011	Using a cyclin D1 3"-UTR reporter construct (CCND1-3"-UTR), we confirmed that this 3"-UTR mediates the inhibitory action of clioquinol, likely through miR-302C.	Clioquinol	124-134	cyclin D1	Homo sapiens	8-17
21868515-5	2011	Using a cyclin D1 3"-UTR reporter construct (CCND1-3"-UTR), we confirmed that this 3"-UTR mediates the inhibitory action of clioquinol, likely through miR-302C.	Clioquinol	124-134	cyclin D1	Homo sapiens	45-50
21868515-6	2011	This study demonstrates for the first time that clioquinol targets post-transcriptional steps of cyclin D1 gene expression in cancer cells, adding new insight into our understanding of its mechanisms of anticancer action.	Clioquinol	48-58	cyclin D1	Homo sapiens	97-106
21325634-11	2011	Sixth, curcumin inhibited expression of cell survival proteins such as B-cell lymphoma-2, B-cell leukemia protein xL, X-linked inhibitor of apoptosis protein, c-FLIP, cellular inhibitor of apoptosis protein (cIAP)-1, cIAP-2 and survivin and proteins linked to cell proliferation, such as cyclin D1 and c-Myc.	Curcumin	7-15	cyclin D1	Homo sapiens	288-297
21750208-8	2011	EGCG treatment corresponded with a decreased abundance of cyclin D1 and diminution of 12-O-tetradecanoylphorbol-l3-acetate-induced AP-1 or NF-kappaB promoter activity in cells expressing Pin1.	epigallocatechin gallate	0-4	cyclin D1	Homo sapiens	58-67
21790999-11	2011	The role of sorafenib-induced degradation of cyclin D1 in the suppression of DOX efficiency is discussed.	Sorafenib	12-21	cyclin D1	Homo sapiens	45-54
21790999-11	2011	The role of sorafenib-induced degradation of cyclin D1 in the suppression of DOX efficiency is discussed.	Doxorubicin	77-80	cyclin D1	Homo sapiens	45-54
21790999-12	2011	In conclusion, MEK/ERK counteraction, stimulation of survival via Akt and dysregulation of cyclin D1 could contribute to the escape from DOX-induced autophagy and thus promote cancer cell survival.	Doxorubicin	137-140	cyclin D1	Homo sapiens	91-100
21932171-2	2011	This study further investigated that formononetin inactivated IGF1/IGF1R-PI3K/Akt pathways and decreased cyclin D1 mRNA and protein expression in human breast cancer cells in vitro and in vivo.	formononetin	37-49	cyclin D1	Homo sapiens	105-114
21932171-11	2011	These results show that formononetin causes cell cycle arrest at the G0/G1 phase by inactivating IGF1/IGF1R-PI3K/Akt pathways and decreasing cyclin D1 mRNA and protein expression, indicating the use of formononetin in the prevention of breast cancer carcinogenesis.	formononetin	24-36	cyclin D1	Homo sapiens	141-150
21373967-7	2011	Time-dependent induction of cell cycle-related genes, such as cyclin D1 and retinoblastoma protein, and amplification of the neural progenitor cell marker, brain lipid binding protein, were suppressed by GGA treatment and were completely abolished by ATRA.	Tretinoin	251-255	cyclin D1	Homo sapiens	62-71
21795396-8	2011	Consequently, calcimycin inhibited Wnt/beta-catenin pathway activity and the expression of prominent beta-catenin target genes such as S100A4, cyclin D1, c-myc, and dickkopf-1.	Calcimycin	14-24	cyclin D1	Homo sapiens	143-152
21777670-7	2011	The major effect of Akt3 on the proliferation of DTC was associated with an Akt3-mediated regulation of both, cyclin D1 and cyclin D3, whereas Akt1 regulated the expression of cyclin D1 only.	dtc	49-52	cyclin D1	Homo sapiens	110-119
21777670-7	2011	The major effect of Akt3 on the proliferation of DTC was associated with an Akt3-mediated regulation of both, cyclin D1 and cyclin D3, whereas Akt1 regulated the expression of cyclin D1 only.	dtc	49-52	cyclin D1	Homo sapiens	176-185
21908486-7	2011	Honokiol down-regulated the expression of cyclin D1, cyclin D2, Cdk2, Cdk4 and Cdk6 proteins and up-regulated the expression of Cdk"s inhibitor proteins p21 and p27.	honokiol	0-8	cyclin D1	Homo sapiens	42-51
21862684-9	2011	PMIP inhibited estradiol-activated reporter gene transcription and endogenous cyclin D1 and nuclear respiratory factor-1 gene transcription in H1793 cells.	pmip	0-4	cyclin D1	Homo sapiens	78-120
22035408-4	2011	RESULTS: The benzothiazole based compounds exhibited effective cytotoxicity at 4 muM concentration and have shown G1 cell cycle arrest with decrease in levels of G1 cell cycle proteins such as cyclin D1 and Skp2.	benzothiazole	13-26	cyclin D1	Homo sapiens	193-202
21840388-7	2011	Annonacin (0.1 muM) induced G(0)/G(1) growth arrest while increasing p21(WAF1) and p27(kip1) and decreasing cyclin D1 protein expression.	annonacin	0-9	cyclin D1	Homo sapiens	108-117
21840388-8	2011	Annonacin (0.1muM) decreased cyclin D1 protein expression more than 4-hydroxytamoxifen (1 muM).	annonacin	0-9	cyclin D1	Homo sapiens	29-38
21840388-14	2011	Moreover, annonacin decreased ERalpha, cyclin D1 and Bcl-2 protein expression in the xenograft at 22 days.	annonacin	10-19	cyclin D1	Homo sapiens	39-48
21786165-5	2011	Growth inhibitory effects of celastrol correlated with a decrease in the levels of cyclin D1 and cyclin E, but concomitant increase in the levels of p21 and p27.	celastrol	29-38	cyclin D1	Homo sapiens	83-92
25961265-9	2011	Furthermore, NaBu down-regulates the proto-oncogenes c-Myc, Cyclin D1 and E2F1 mRNA levels.	sethoxydim	13-17	cyclin D1	Homo sapiens	60-69
21687939-5	2011	Treatment with cisplatin plus TRAIL also inhibits Wnt-1 signaling and its downstream target, beta-catenin, phospho beta-catenin, cyclin D1, increased apoptosis, reduced proliferation and mammosphere formation.	Cisplatin	15-24	cyclin D1	Homo sapiens	129-138
21600278-9	2011	In conclusion, these results demonstrate that activation of p38 MAPK contributes to esculetin-induced p21WAF1 expression in VSMC by decreasing both the cyclin D1/CDK4 and cyclin E/CDK2 complexes.	esculetin	84-93	cyclin D1	Homo sapiens	152-161
21961478-4	2011	Most of the miRNA target genes that showed altered expression could be classified as apoptotic genes and were up-regulated by PUFA or temozolomide treatment, while similar treatments resulted in repression of the corresponding mRNAs, such as cox2, irs1, irs2, ccnd1, itgb3, bcl2, sirt1, tp53inp1 and k-ras.	Fatty Acids, Unsaturated	126-130	cyclin D1	Homo sapiens	260-265
21961478-4	2011	Most of the miRNA target genes that showed altered expression could be classified as apoptotic genes and were up-regulated by PUFA or temozolomide treatment, while similar treatments resulted in repression of the corresponding mRNAs, such as cox2, irs1, irs2, ccnd1, itgb3, bcl2, sirt1, tp53inp1 and k-ras.	Temozolomide	134-146	cyclin D1	Homo sapiens	260-265
21782921-0	2011	Ferulic acid promotes endothelial cells proliferation through up-regulating cyclin D1 and VEGF.	ferulic acid	0-12	cyclin D1	Homo sapiens	76-85
22025972-6	2011	Vitamin D3 treatment decreased the level of mRNA expression of patched1, Gli1, cyclin D1, and Bcl2, suggesting the possibility that vitamin D3 may act through regulation of hedgehog signaling.	Cholecalciferol	0-10	cyclin D1	Homo sapiens	79-88
22025972-6	2011	Vitamin D3 treatment decreased the level of mRNA expression of patched1, Gli1, cyclin D1, and Bcl2, suggesting the possibility that vitamin D3 may act through regulation of hedgehog signaling.	Cholecalciferol	132-142	cyclin D1	Homo sapiens	79-88
21480364-0	2011	Transcriptional and post-transcriptional down-regulation of cyclin D1 contributes to C6 glioma cell differentiation induced by forskolin.	Colforsin	127-136	cyclin D1	Homo sapiens	60-69
21480364-3	2011	In mechanisms, we verified that forskolin significantly diminishes the mRNA and protein level of a key cell cycle regulator cyclin D1, and maintenance of low cyclin D1 expression level was required for forskolin-induced proliferation inhibition and differentiation by gain and loss of function approaches.	Colforsin	32-41	cyclin D1	Homo sapiens	124-133
21480364-3	2011	In mechanisms, we verified that forskolin significantly diminishes the mRNA and protein level of a key cell cycle regulator cyclin D1, and maintenance of low cyclin D1 expression level was required for forskolin-induced proliferation inhibition and differentiation by gain and loss of function approaches.	Colforsin	202-211	cyclin D1	Homo sapiens	124-133
21480364-3	2011	In mechanisms, we verified that forskolin significantly diminishes the mRNA and protein level of a key cell cycle regulator cyclin D1, and maintenance of low cyclin D1 expression level was required for forskolin-induced proliferation inhibition and differentiation by gain and loss of function approaches.	Colforsin	202-211	cyclin D1	Homo sapiens	158-167
21480364-4	2011	In addition, that forskolin down-regulated the cyclin D1 by proteolytic (post-transcriptional) mechanisms was dependent on GSK-3beta activation at Ser9.	Colforsin	18-27	cyclin D1	Homo sapiens	47-56
21251937-6	2011	Nilotinib induced apoptosis of HSCs, which was correlated with reduced bcl-2 expression, increased p53 expression, cleavage of PARP, as well as increased expression of PPARgamma and TRAIL-R. Nilotinib also induced cell cycle arrest, accompanied by increased expression of p27 and downregulation of cyclin D1.	nilotinib	0-9	cyclin D1	Homo sapiens	298-307
21251937-6	2011	Nilotinib induced apoptosis of HSCs, which was correlated with reduced bcl-2 expression, increased p53 expression, cleavage of PARP, as well as increased expression of PPARgamma and TRAIL-R. Nilotinib also induced cell cycle arrest, accompanied by increased expression of p27 and downregulation of cyclin D1.	nilotinib	191-200	cyclin D1	Homo sapiens	298-307
22942585-8	2011	RESULTS: No significant difference in Cyclin-D1 and Ki67 levels were found between the two groups with different grades of dysplasia, however, decreased Cyclin-D1 was found in those patients treated with KTP laser (P = 0.028).	KTP compound	204-207	cyclin D1	Homo sapiens	153-162
21719533-6	2011	We show that mutation of PAK1 Tyr 153, 201, and 285 (sites of JAK2 phosphorylation; PAK1 Y3F) decreases both PAK1 nuclear translocation in response to PRL and PRL-induced cyclin D1 promoter activity by 55%.	Tyrosine	30-33	cyclin D1	Homo sapiens	171-180
21719533-11	2011	We propose two PAK1-dependent mechanisms to activate cyclin D1 promoter activity in response to PRL: via nuclear translocation of tyrosyl-phosphorylated PAK1 and via formation of a Nck-PAK1 complex that sequesters PAK1 in the cytoplasm.	cyclo(tyrosyl-tyrosyl)	130-137	cyclin D1	Homo sapiens	53-62
21546908-8	2011	Knockdown of hif2alpha, birc5a or birc5b reduced the expression of the cdk inhibitors p27/cdkn1b and p57/cdkn1c and increased ccnd1/cyclin D1 transcription in the surviving neural progenitor cells.	birc5a	24-30	cyclin D1	Homo sapiens	132-141
21829151-5	2011	Treatment with parthenolide led to G1 phase cell cycle arrest in 5637 cells by modulation of cyclin D1 and phosphorylated cyclin-dependent kinase 2.	parthenolide	15-27	cyclin D1	Homo sapiens	93-102
21383690-4	2011	RA treatment rapidly induced morphology changes, induced growth arrest at G1/G0 to S transition, decreased cyclin D1 expression and increased p27 expression.	Tretinoin	0-2	cyclin D1	Homo sapiens	107-116
21717584-4	2011	Further studies revealed that the protein level of cyclin D1 decreased and the percentage of the cells in G0/G1 phase increased by 5 mM metformin treatment.	Metformin	136-145	cyclin D1	Homo sapiens	51-60
21717584-7	2011	In a summary, metformin prevents proliferation of C666-1 cells by down-regulating cyclin D1 level and inducing G1 cell cycle arrest.	Metformin	14-23	cyclin D1	Homo sapiens	82-91
21620794-7	2011	These carotenoids up-regulated the expression of PPARgamma and p21 and down-regulated the expression of cyclin D1 in a dose-dependent manner.	Carotenoids	6-17	cyclin D1	Homo sapiens	104-113
20821348-0	2011	The rexinoid bexarotene represses cyclin D1 transcription by inducing the DEC2 transcriptional repressor.	Bexarotene	13-23	cyclin D1	Homo sapiens	34-43
20821348-2	2011	While investigating the mechanism by which bexarotene prevents ER-negative breast cancer development, we found that the expression of cyclin D1, a critical cell cycle promoter, was repressed by bexarotene in vitro and in vivo.	Bexarotene	43-53	cyclin D1	Homo sapiens	134-143
20821348-2	2011	While investigating the mechanism by which bexarotene prevents ER-negative breast cancer development, we found that the expression of cyclin D1, a critical cell cycle promoter, was repressed by bexarotene in vitro and in vivo.	Bexarotene	194-204	cyclin D1	Homo sapiens	134-143
20821348-3	2011	Time course and cycloheximide experiments show that repression of cyclin D1 is a late effect and requires new protein synthesis.	Cycloheximide	16-29	cyclin D1	Homo sapiens	66-75
20821348-5	2011	Therefore, we hypothesized that bexarotene represses the transcription of cyclin D1 through induction of DEC2.	Bexarotene	32-42	cyclin D1	Homo sapiens	74-83
20821348-6	2011	Luciferase reporter studies demonstrated that either bexarotene treatment or forced expression of DEC2 can repress the transcription of a cyclin D1 promoter reporter by affecting the basal transcriptional activity.	Bexarotene	53-63	cyclin D1	Homo sapiens	138-147
20821348-7	2011	Results from chromatin immunoprecipitation experiments showed that bexarotene treatment causes the recruitment of DEC2 and HDAC1 (histone deacetylase 1) to the cyclin D1 promoter.	Bexarotene	67-77	cyclin D1	Homo sapiens	160-169
20821348-9	2011	Trichostatin A, a HDAC inhibitor, reverses the cyclin D1 repression by bexarotene, suggesting that repression of cyclin D1 involves histone deacetylation.	trichostatin A	0-14	cyclin D1	Homo sapiens	47-56
20821348-9	2011	Trichostatin A, a HDAC inhibitor, reverses the cyclin D1 repression by bexarotene, suggesting that repression of cyclin D1 involves histone deacetylation.	trichostatin A	0-14	cyclin D1	Homo sapiens	113-122
20821348-9	2011	Trichostatin A, a HDAC inhibitor, reverses the cyclin D1 repression by bexarotene, suggesting that repression of cyclin D1 involves histone deacetylation.	Bexarotene	71-81	cyclin D1	Homo sapiens	47-56
20821348-9	2011	Trichostatin A, a HDAC inhibitor, reverses the cyclin D1 repression by bexarotene, suggesting that repression of cyclin D1 involves histone deacetylation.	Bexarotene	71-81	cyclin D1	Homo sapiens	113-122
20821348-12	2011	These results suggest that bexarotene down-regulates cyclin D1 through induction of DEC2, followed by recruitment of HDAC1 to the cyclin D1 promoter causing transcriptional repression.	Bexarotene	27-37	cyclin D1	Homo sapiens	53-62
20821348-12	2011	These results suggest that bexarotene down-regulates cyclin D1 through induction of DEC2, followed by recruitment of HDAC1 to the cyclin D1 promoter causing transcriptional repression.	Bexarotene	27-37	cyclin D1	Homo sapiens	130-139
21222129-6	2011	However, BCAA supplementation reduced the loss of myofibrillar proteins and RNA, attenuated the increases in 4E-BP1, and partially preserved cyclin D1, mTOR and ERK1 proteins.	Amino Acids, Branched-Chain	9-13	cyclin D1	Homo sapiens	141-150
21592546-6	2011	Cisplatin also potently inhibited G1-phase Cdk4/cyclin D1 and Cdk2/cyclin E activities at ~18 h. In agreement, exposure of cisplatin-treated A2780, HCT-116(p53-/-) and HCT-116(p21-/-) tumor cells to nocodazole revealed limited G1-arrest that was dependent on p53 and p21.	Cisplatin	0-9	cyclin D1	Homo sapiens	48-57
21592546-6	2011	Cisplatin also potently inhibited G1-phase Cdk4/cyclin D1 and Cdk2/cyclin E activities at ~18 h. In agreement, exposure of cisplatin-treated A2780, HCT-116(p53-/-) and HCT-116(p21-/-) tumor cells to nocodazole revealed limited G1-arrest that was dependent on p53 and p21.	Cisplatin	123-132	cyclin D1	Homo sapiens	48-57
21699455-7	2011	Curcumin-ND decreased cyclin D1, pAkt, pIkappaBalpha, and Bcl(2) protein.	Curcumin	0-8	cyclin D1	Homo sapiens	22-31
21726525-5	2011	Moreover, 2-decylamino-DMNQ suppressed DNA synthesis through the arrest of cell cycle progression at the G(0)/G(1) phase, including the suppression of pRb phosphorylation and a decrease in PCNA expression, which was related to the downregulation of cell cycle regulatory factors, such as cyclin D1/E and CDK 2/4.	2-decylamino-5,8-dimethoxy-1,4-naphthoquinone	10-27	cyclin D1	Homo sapiens	288-299
21356307-4	2011	Here, we show that mutation of the ERalpha monoUbq sites prevents the E2-induced ERalpha phosphorylation in the serine residue 118 (S118), reduces ERalpha transcriptional activity, and precludes the ERalpha-mediated extranuclear activation of signaling pathways (i.e., AKT activation) thus impeding the E2-induced cyclin D1 promoter activation and consequently cell proliferation.	monoubq	43-50	cyclin D1	Homo sapiens	314-323
21788521-6	2011	In otherwise unmanipulated chronic lymphocytic leukemia cells with constitutive Wnt activation nanomolar concentrations of salinomycin down-regulated the expression of Wnt target genes such as LEF1, cyclin D1, and fibronectin, depressed LRP6 levels, and limited cell survival.	salinomycin	123-134	cyclin D1	Homo sapiens	199-208
21453743-7	2011	delta-Tocotrienol also decreased cyclin D1, c-jun and MMP-7 protein levels in SW620 cells.	tocotrienol, delta	0-17	cyclin D1	Homo sapiens	33-42
21062395-5	2011	Both RPA1 and RPA2 LIs were positively correlated with cyclin D1 expression (rho = 0.354, P &lt; 0.001 and rho = 0.934, P &lt; 0.001).	lis	19-22	cyclin D1	Homo sapiens	55-64
21435102-7	2011	The inhibition of STAT3 by XZH-5 was confirmed by the inhibition of STAT3 DNA binding ability and the downregulation of STAT3 downstream genes, such as Bcl-2, Bcl-xL, Cyclin D1 and Survivin; we also demonstrated that blockade of STAT3 phosphorylation in human rhabdomyosarcoma cells with XZH-5 caused apoptosis and suppressed colony-forming ability and cell migration.	XZH-5	27-32	cyclin D1	Homo sapiens	167-176
21314641-0	2011	Roles of the ERK, JNK/AP-1/cyclin D1-CDK4 pathway in silica-induced cell cycle changes in human embryo lung fibroblast cells.	Silicon Dioxide	53-59	cyclin D1	Homo sapiens	27-36
21314641-7	2011	Moreover, pretreatment of cells with curcumin, an activation of AP-1 (activator protein-1) inhibitor, inhibited silica-induced cell cycle alteration, the decreased expression of E2F-4 and overexpression of cyclin D1 and CDK4.	Curcumin	37-45	cyclin D1	Homo sapiens	206-215
21314641-7	2011	Moreover, pretreatment of cells with curcumin, an activation of AP-1 (activator protein-1) inhibitor, inhibited silica-induced cell cycle alteration, the decreased expression of E2F-4 and overexpression of cyclin D1 and CDK4.	Silicon Dioxide	112-118	cyclin D1	Homo sapiens	206-215
21314641-8	2011	Furthermore, both antisense cyclin D1 and antisense CDK4 can block silica-induced cell cycle changes.	Silicon Dioxide	67-73	cyclin D1	Homo sapiens	28-37
21314641-9	2011	These results suggest that silica exposure can induce cell cycle changes, which may be mediated through ERK, JNK/AP-1/cyclin D1-CDK4-dependent pathway.	Silicon Dioxide	27-33	cyclin D1	Homo sapiens	118-127
21356307-4	2011	Here, we show that mutation of the ERalpha monoUbq sites prevents the E2-induced ERalpha phosphorylation in the serine residue 118 (S118), reduces ERalpha transcriptional activity, and precludes the ERalpha-mediated extranuclear activation of signaling pathways (i.e., AKT activation) thus impeding the E2-induced cyclin D1 promoter activation and consequently cell proliferation.	Serine	112-118	cyclin D1	Homo sapiens	314-323
21726064-9	2011	The protein levels of both total Smad3 and phosphorylated Smad3 were both up-regulated after berbamine treatment, together with decreased c-Myc and cyclin D1 and increased p21.	berbamine	93-102	cyclin D1	Homo sapiens	148-157
20951021-7	2011	Western blotting and immunoprecipitation demonstrated that denbinobin causes more efficient inhibition of IGF-1-induced activation of IGF-1R and its downstream signaling targets, including , extracellular signal-regulated kinase, Akt, mTOR, p70S6K, 4EBP and cyclin D1.	denbinobin	59-69	cyclin D1	Homo sapiens	258-267
21566064-6	2011	We showed that CBD induces endoplasmic reticulum stress and, subsequently, inhibits AKT and mTOR signaling as shown by decreased levels of phosphorylated mTOR and 4EBP1, and cyclin D1.	Cannabidiol	15-18	cyclin D1	Homo sapiens	174-183
22214150-5	2011	It was found that ERK and JNK were involved in silica-induced cyclin D1 and CDK4 overexpression and the decreased expression of E2F-4.	Silicon Dioxide	47-53	cyclin D1	Homo sapiens	62-71
21601455-1	2011	Naphtho[2,1-alpha]pyrrolo[3,4-c]carbazole-5,7(6H,12H)-dione (NPCD) is known to be a very potent and selective cyclin D1-CDK4 inhibitors and could induce strong G1 phase arrest in breast tumor cell lines.	naphtho[2,1-alpha]pyrrolo[3,4-c]carbazole-5,7(6h,12h)-dione	0-59	cyclin D1	Homo sapiens	110-119
21624348-7	2011	The MEK inhibitor, PD0325901, inhibits proliferation and ERK1/2 phosphorylation while also suppressing the expression of Cyclin D1.	mirdametinib	19-28	cyclin D1	Homo sapiens	121-130
21601455-1	2011	Naphtho[2,1-alpha]pyrrolo[3,4-c]carbazole-5,7(6H,12H)-dione (NPCD) is known to be a very potent and selective cyclin D1-CDK4 inhibitors and could induce strong G1 phase arrest in breast tumor cell lines.	npcd	61-65	cyclin D1	Homo sapiens	110-119
21508089-14	2011	Leucine did not affect the mTOR pathway but did increase the phosphorylation states of PI3K, Akt, AMPK, p38 MAPK, JNK, GSK-3alpha/beta, STAT3, and STAT5 and increased cyclin D1 mRNA concentrations, which suggested that leucine may enhance cell proliferation.	Leucine	0-7	cyclin D1	Homo sapiens	167-176
21435184-2	2011	We recently found that Rottlerin caused growth arrest in MCF-7 breast cancer cells and human immortalized keratinocytes, through inhibition of NFkappaB and downregulation of cyclin D-1.	rottlerin	23-32	cyclin D1	Homo sapiens	174-184
20607601-7	2011	Cyclin D1 was primarily cytoplasmic in 3D cultures, and this was accompanied by decreased phosphorylation of Rb, a nuclear target for both cyclin E1- and cyclin D1-associated kinases.	Rubidium	109-111	cyclin D1	Homo sapiens	0-9
20607601-7	2011	Cyclin D1 was primarily cytoplasmic in 3D cultures, and this was accompanied by decreased phosphorylation of Rb, a nuclear target for both cyclin E1- and cyclin D1-associated kinases.	Rubidium	109-111	cyclin D1	Homo sapiens	154-163
21411221-5	2011	To conclude, H(2)O(2) scavenging may induce cell cycle arrest through the modulation of cyclin D1 and p27(KIP1) levels and nuclear localization of p27(KIP1).	Hydrogen Peroxide	13-21	cyclin D1	Homo sapiens	88-97
21538933-4	2011	NPPB treatment decreased the mRNA and the protein expression of Bax/Bcl-2, decreased the protein expressions of cytochrome C and caspase-3, and increased the mRNA expressions of cyclin D1 and ClC-3 in cells treated with cisplatin.	Cisplatin	220-229	cyclin D1	Homo sapiens	178-187
21241249-0	2011	A novel antioestrogen agent (3R,6R)-bassiatin inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression in 17beta-oestradiol-treated MCF-7 cells.	(3r,6r)-bassiatin	28-45	cyclin D1	Homo sapiens	115-124
21241249-0	2011	A novel antioestrogen agent (3R,6R)-bassiatin inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression in 17beta-oestradiol-treated MCF-7 cells.	Estradiol	139-156	cyclin D1	Homo sapiens	115-124
21241249-3	2011	In addition, the mRNA and protein levels of ERalpha and the oestrogen-responsive gene cyclin D1 were down-regulated by bassiatin in the presence of 17beta-oestradiol.	Estradiol	148-165	cyclin D1	Homo sapiens	86-95
21241249-4	2011	Co-treatment of 17beta-oestradiol and bassiatin increased phospho-cyclin D1 (Thr286), an indicator of cyclin D1 phosphorylation-dependent degradation.	Estradiol	16-33	cyclin D1	Homo sapiens	66-75
21241249-4	2011	Co-treatment of 17beta-oestradiol and bassiatin increased phospho-cyclin D1 (Thr286), an indicator of cyclin D1 phosphorylation-dependent degradation.	Estradiol	16-33	cyclin D1	Homo sapiens	102-111
21241249-4	2011	Co-treatment of 17beta-oestradiol and bassiatin increased phospho-cyclin D1 (Thr286), an indicator of cyclin D1 phosphorylation-dependent degradation.	lateritin	38-47	cyclin D1	Homo sapiens	66-75
21241249-4	2011	Co-treatment of 17beta-oestradiol and bassiatin increased phospho-cyclin D1 (Thr286), an indicator of cyclin D1 phosphorylation-dependent degradation.	lateritin	38-47	cyclin D1	Homo sapiens	102-111
21241249-5	2011	However, this effect was not obvious in the absence of 17beta-oestradiol, suggesting that bassiatin may play a role in the metabolism of cyclin D1 by decreasing cyclin D1 protein expression in the presence of 17beta-oestradiol.	lateritin	90-99	cyclin D1	Homo sapiens	137-146
21241249-5	2011	However, this effect was not obvious in the absence of 17beta-oestradiol, suggesting that bassiatin may play a role in the metabolism of cyclin D1 by decreasing cyclin D1 protein expression in the presence of 17beta-oestradiol.	lateritin	90-99	cyclin D1	Homo sapiens	161-170
21241249-7	2011	Decreased cyclin D1 was found to be involved in bassiatin-induced MCF-7 cell cycle arrest.	lateritin	48-57	cyclin D1	Homo sapiens	10-19
21636548-1	2011	The rexinoid bexarotene represses cyclin D1 by causing its proteasomal degradation.	Bexarotene	13-23	cyclin D1	Homo sapiens	34-43
21636548-2	2011	The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) erlotinib represses cyclin D1 via different mechanisms.	Erlotinib Hydrochloride	76-85	cyclin D1	Homo sapiens	96-105
21435184-4	2011	In this study, we demonstrated that Rottlerin prevents basal and TNFalpha-stimulated NFkappaB nuclear migration and DNA binding also in human microvascular endothelial cell, where NFkappaB inhibition was accompanied by the downregulation of NFkappaB target gene products, such as cyclin D-1 and endothelin-1, which are essential molecules for endothelial cell proliferation and survival.	rottlerin	36-45	cyclin D1	Homo sapiens	280-290
21242960-4	2011	Mechanistically, miR-378 achieves this oncogenic effect, at least in part, by targeting and inhibiting the anti-proliferative BTG family member, TOB2, which is further elucidated as a candidate tumor suppressor to transcriptionally repress proto-oncogene cyclin D1.	beta-2'-deoxythioguanosine	126-129	cyclin D1	Homo sapiens	255-264
21729550-7	2011	And RT-PCR showed, as compared with curcumin or bortezomib group, there was mRNA expression decrease of BCL-2, cyclin D1 but increase of BAX in combined group.	Curcumin	36-44	cyclin D1	Homo sapiens	111-120
21729550-7	2011	And RT-PCR showed, as compared with curcumin or bortezomib group, there was mRNA expression decrease of BCL-2, cyclin D1 but increase of BAX in combined group.	Bortezomib	48-58	cyclin D1	Homo sapiens	111-120
20669221-6	2011	DMAPT suppressed cyclin D1 in BEAS2B.	LC-1 compound	0-5	cyclin D1	Homo sapiens	17-26
21458521-7	2011	Over expression of an active EGFR in vitamin D sensitive ovarian cancer cells caused resistance to 1,25(OH)(2)D(3)-induced growth suppression and diminished the hormonal regulation of cyclin D1, cyclin E, Skp2 and p27, a group of cell cycle regulators that mediate 1,25(OH)(2)D(3)-induced cell cycle arrest at G1-S checkpoint.	Vitamin D	37-46	cyclin D1	Homo sapiens	184-193
21411630-5	2011	Disruption of the cyclin D1/ZO complex through mutagenesis or siRNA-mediated suppression of ZO-3 resulted in increased cyclin D1 proteolysis and G(0)/G(1) cell-cycle retention.	zo-3	92-96	cyclin D1	Homo sapiens	18-27
21411630-5	2011	Disruption of the cyclin D1/ZO complex through mutagenesis or siRNA-mediated suppression of ZO-3 resulted in increased cyclin D1 proteolysis and G(0)/G(1) cell-cycle retention.	zo-3	92-96	cyclin D1	Homo sapiens	119-128
21198544-9	2011	gamma-Tocotrienol also down-regulated the expression of STAT3-regulated gene products, including cyclin D1, Bcl-2, Bcl-xL, survivin, Mcl-1 and vascular endothelial growth factor.	plastochromanol 8	0-17	cyclin D1	Homo sapiens	97-106
21242975-8	2011	We have also observed that CycD1-Cdk4 phosphorylates the Ral GEF Rgl2 "in vitro" and that CycD1-Cdk4 activity stimulates accumulation of the Ral GTP active forms.	Guanosine Triphosphate	145-148	cyclin D1	Homo sapiens	90-95
21234653-9	2011	Mechanistically, DHA activated caspase-3, caspase-8, and caspase-9; upregulated the expression of Bax, FAS, and cyclin D1; downregulated the expression of Bcl-2, Cdc25B, and cyclin B1; and inhibited the activity of NF-kB.	artenimol	17-20	cyclin D1	Homo sapiens	112-121
21331449-7	2011	GA mediated the G0/G1 phase arrest in U2OS cells; this arrest was associated with a decrease in phospho-GSK3-beta (Ser9) and the expression of cyclin D1.	gambogic acid	0-2	cyclin D1	Homo sapiens	143-152
25961258-3	2011	RESULTS: In estrogen receptor alpha (ERalpha)-positive MCF-7 and T47-D cells, TSA induced a long-term degradation of cyclin A and a proteasome-dependent loss of ERalpha and cyclin D1, allowed derepression of p21WAF1/CIP1, HDAC1 and RhoB GTPase, concomitantly with blockade in G2/M of the cell cycle and apoptosis induction.	trichostatin A	78-81	cyclin D1	Homo sapiens	173-182
20945354-5	2011	We found that treatment of nucleus pulposus (NP) cells with the Wnt/beta-catenin activator lithium chloride (LiCl) results in the increased expression of beta-catenin mRNA and protein, and cell proliferation is decreased due to the activation of the Wnt/beta-catenin signals through the suppression of c-myc and cyclin-D1.	Lithium Chloride	91-107	cyclin D1	Homo sapiens	312-321
20945354-5	2011	We found that treatment of nucleus pulposus (NP) cells with the Wnt/beta-catenin activator lithium chloride (LiCl) results in the increased expression of beta-catenin mRNA and protein, and cell proliferation is decreased due to the activation of the Wnt/beta-catenin signals through the suppression of c-myc and cyclin-D1.	Lithium Chloride	109-113	cyclin D1	Homo sapiens	312-321
21352912-2	2011	The study aims to investigate the effect of Curcumin on the expression of GSK-3beta, beta-catenin and CyclinD1 in vitro, which are tightly correlated with Wnt/beta-catenin signaling pathway, and also to explore the mechanisms, which will provide a novel therapeutic intervention for treatment of Alzheimer"s disease.	Curcumin	44-52	cyclin D1	Homo sapiens	102-110
21438905-3	2011	Cyclin D1 was correlated with various tumour features and biochemical recurrence-free survival (bRFS), disease-specific survival (DSS) and overall survival (OS).	dss	130-133	cyclin D1	Homo sapiens	0-9
21397587-8	2011	We found that genes downstream of STAT3 (BCL-2, survivin, cyclin D1) were downregulated with celecoxib.	Celecoxib	93-102	cyclin D1	Homo sapiens	58-67
21257919-4	2011	Real-time qRT-PCR analysis showed that DHT induced androgen receptor (AR), cyclin A, cyclin D1, and vascular endothelial growth factor (VEGF) gene expression in a dose- and time-dependent manner.	Dihydrotestosterone	39-42	cyclin D1	Homo sapiens	85-94
21394647-9	2011	Blocking BCR signaling by Syk inhibitor piceatannol induced dose/time-dependent apoptosis in MCL cell lines, as well as several modifications in the phosphorylation status of BCR pathway members and a collapse of cyclin D1 protein levels.	3,3',4,5'-tetrahydroxystilbene	40-51	cyclin D1	Homo sapiens	213-222
21438905-4	2011	In the metastases, high-level cytoplasmic cyclin D1 expression independently predicted poor outcome (5-year bRFS, 12.5% versus 26.4%, P = 0.006; 5-year DSS, 56.3% versus 80.7%, P = 0.007; 5-year OS, 56.3% versus 78.7%, P = 0.011).	dss	152-155	cyclin D1	Homo sapiens	42-51
21385053-1	2011	BACKGROUND: Melatonin suppresses breast cancer cell proliferation by inhibiting the upregulation of estrogen-induced cyclin D1 via its G-protein-coupled receptor MT1.	Melatonin	12-21	cyclin D1	Homo sapiens	117-126
22468037-0	2011	Influence of Bcl-1 Gene Polymorphism of Glucocorticoid Receptor Gene (NR3C1, rs41423247) on Blood Pressure, Glucose in Northern Indians.	Glucose	108-115	cyclin D1	Homo sapiens	13-18
21537090-3	2011	METHODS: Immunohistochemistry for cyclin D1 and DNA flowcytometry for cell cycle parameters was done on paraffin embedded tumour samples from 45 patients with OSCC RESULTS: Higher expression of cyclin D1 was observed only in 30 (66.6%) of 45 cases that correlated with advanced age (P &lt;0.02), higher tumour stage (P&lt;0.01), histological differentiation and lymph node metastasis (P &lt;0.01).	Paraffin	104-112	cyclin D1	Homo sapiens	194-203
21537090-5	2011	INTERPRETATION &amp; CONCLUSIONS: Higher expression of cyclin D1 in oral cancer appears to be closely linked to cell proliferation, differentiation and lymph node invasion.	Adenosine Monophosphate	16-19	cyclin D1	Homo sapiens	55-64
20857402-4	2011	Knocking down either cyclin A or cyclin D1 by small interfering RNA (siRNA) inhibited homocysteine-induced cell proliferation.	Homocysteine	86-98	cyclin D1	Homo sapiens	33-42
20857402-5	2011	Furthermore, treatment with extracellular signal-related kinase (ERK) inhibitor (PD98059) and dominant negative Ras (RasN17) abolished homocysteine-induced cyclin A expression; and treatment with phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002) and mammalian target of rapamycin (mTOR) inhibitor (rapamycin) attenuated the homocysteine-induced cyclin D1 expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	81-88	cyclin D1	Homo sapiens	353-362
20857402-5	2011	Furthermore, treatment with extracellular signal-related kinase (ERK) inhibitor (PD98059) and dominant negative Ras (RasN17) abolished homocysteine-induced cyclin A expression; and treatment with phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002) and mammalian target of rapamycin (mTOR) inhibitor (rapamycin) attenuated the homocysteine-induced cyclin D1 expression.	Homocysteine	135-147	cyclin D1	Homo sapiens	353-362
21198643-7	2011	RESULTS: Proliferating cell nuclear antigen and cyclin D1 mRNAs (Pcna and Ccnd1, respectively) were expressed more strongly in the gingivae of cyclosporine A-treated animals than in the gingivae of the controls.	Cyclosporine	143-157	cyclin D1	Homo sapiens	48-57
21198643-7	2011	RESULTS: Proliferating cell nuclear antigen and cyclin D1 mRNAs (Pcna and Ccnd1, respectively) were expressed more strongly in the gingivae of cyclosporine A-treated animals than in the gingivae of the controls.	Cyclosporine	143-157	cyclin D1	Homo sapiens	74-79
21198643-8	2011	Immunohistochemical analyses showed that a greater number of gingival cells stained positive for cyclin D1, CDK4 and pRb1 in the cyclosporine A group than in the control group.	Cyclosporine	129-143	cyclin D1	Homo sapiens	97-106
21198643-9	2011	Increased expression of cyclin D1, CDK4 and PCNA proteins was observed in HGFs after cyclosporine A treatment.	Cyclosporine	85-99	cyclin D1	Homo sapiens	24-33
21198643-11	2011	CONCLUSION: The increases in cyclin D1, PCNA and CDK4, together with the enhanced phosphorylation of Rb1, suggest that cyclosporine A promotes cell-cycle progression through the G(1)/S transition in the gingiva.	Cyclosporine	119-133	cyclin D1	Homo sapiens	29-38
21278246-9	2011	Copy number variations of CDKN2A, RB, CCNE1, and CCND1 were associated with response to PD-0332991.	palbociclib	88-98	cyclin D1	Homo sapiens	49-54
21284537-0	2011	Regulation of CD1, Ki-67, PCNA mRNA expression, and Akt activation in estrogen-responsive human breast adenocarcinoma cell line, MCF-7 cells, by griffonianone C, an isoflavone derived from Millettia griffoniana.	C27H28O6	145-160	cyclin D1	Homo sapiens	14-17
21518487-6	2011	Compared with results of Western blot before treatment, expression of inactivated GSK-3beta, beta-catenin and Cyclin-D1 down-regulated in a dose-dependent manner after treatment with sorafenib, this same changes were observed after up-regulation of inactivated GSK-3beta by LiCl (p &lt; 0.05).	Sorafenib	183-192	cyclin D1	Homo sapiens	110-119
21518487-6	2011	Compared with results of Western blot before treatment, expression of inactivated GSK-3beta, beta-catenin and Cyclin-D1 down-regulated in a dose-dependent manner after treatment with sorafenib, this same changes were observed after up-regulation of inactivated GSK-3beta by LiCl (p &lt; 0.05).	Lithium Chloride	274-278	cyclin D1	Homo sapiens	110-119
21518487-7	2011	It is concluded that sorafenib inhibits the proliferation of U937 cells and induces cell apoptosis through reducing negative regulation of WNT signal pathway on inactivated GSK-3beta and down-regulating beta-catenin and cyclin-D1 level, which result in U937 cell cycle G(1)/G(0) arrest.	Sorafenib	21-30	cyclin D1	Homo sapiens	220-229
21447798-3	2011	AZD6244-resistant derivatives were refractory to AZD6244-induced cell cycle arrest and death and exhibited a marked increase in ERK1/2 (extracellular signal-regulated kinases 1 and 2) pathway signaling and cyclin D1 abundance when assessed in the absence of inhibitor.	AZD 6244	0-7	cyclin D1	Homo sapiens	206-215
21407223-7	2011	Sorafenib-induced growth suppression was associated with not only inhibition of angiogenic targets p-PDGFR-beta, p-VEGFR-2, and their downstream signalling pathways p-Akt and p-ERK, cell cycle, and anti-apoptotic proteins that include cyclin D1, cyclin B1, and survivin but also upregulation of proapoptotic Bim.	Sorafenib	0-9	cyclin D1	Homo sapiens	235-244
20702488-8	2011	Antiproliferative effect after treatment with TXL was assessed by determination of the protein levels of p21, cyclinD1, PCNA, and cdk-2, which are the key regulators for cell cycle progression.	Docetaxel	46-49	cyclin D1	Homo sapiens	110-118
21130856-9	2011	Flow cytometry analyses and Western blot demonstrated that treatment with TS extracts and gallic acid induced G(0)/G(1) arrest in VEGF-stimulated EA.hy 926 cells via a reduction in the amounts of cyclin D1, cyclin E, CDK4, hyperphosphorylated retinoblastoma protein (pRb), VEGFR-2, and eNOS.	Gallic Acid	90-101	cyclin D1	Homo sapiens	196-205
21408143-3	2011	Icaritin-inhibited cell growth was associated with increased levels of p21 and p27 expression and reduced cyclinD1 and cdk 4 expression.	icaritin	0-8	cyclin D1	Homo sapiens	106-114
21343394-5	2011	The bound cyclin D1 decreases the supply of ADP, ATP, and metabolites, thereby reducing energy production.	Adenosine Diphosphate	44-47	cyclin D1	Homo sapiens	10-19
21343394-5	2011	The bound cyclin D1 decreases the supply of ADP, ATP, and metabolites, thereby reducing energy production.	Adenosine Triphosphate	49-52	cyclin D1	Homo sapiens	10-19
20883815-7	2011	Up-regulation of Cyclin-D1, Cox-2, XIAP and cIAP1 and phosphorylation of MAPKs, were completely inhibited on inactivation of NF-kappaB assigning a key regulatory role to NF-kappaB in the synergistic effect of paclitaxel and curcumin.	Paclitaxel	209-219	cyclin D1	Homo sapiens	17-26
20883815-7	2011	Up-regulation of Cyclin-D1, Cox-2, XIAP and cIAP1 and phosphorylation of MAPKs, were completely inhibited on inactivation of NF-kappaB assigning a key regulatory role to NF-kappaB in the synergistic effect of paclitaxel and curcumin.	Curcumin	224-232	cyclin D1	Homo sapiens	17-26
21093092-10	2011	In vivo, Peg-IFN treatment led to increased nuclear RanBP3, decreased nuclear beta-catenin and cyclin D1, and decreased cytoplasmic glutamine synthetase.	peg-ifn	9-16	cyclin D1	Homo sapiens	95-104
21108658-7	2011	Western blot and real-time PCR analyses further confirmed that melatonin"s inhibitory effect was possibly because of downregulation of cyclin D1 and CDK4, related to the G(1) phase, and of cyclin B1 and CDK1, related to the G(2) /M phase.	Melatonin	63-72	cyclin D1	Homo sapiens	135-144
21108658-10	2011	These findings provide evidence that melatonin may significantly delay osteoblast proliferation in a time-dependent manner and this inhibition involves the downregulation of cyclin D1 and CDK4, related to the G(1) phase, and of cyclin B1 and CDK1, related to the G(2) /M phase.	Melatonin	37-46	cyclin D1	Homo sapiens	174-183
20143187-2	2011	We have identified that Wnt2/beta-catenin pathway is activated in ESCC cells and sodium nitroprusside (SNP) and siRNA against beta-catenin not only inhibit the expressions of beta-catenin and its major downstream effectors including c-myc and cyclin D1 but induce cell cycle arrest and apoptosis.	Nitroprusside	81-101	cyclin D1	Homo sapiens	243-252
21378327-5	2011	The effect of zeranol-serum on mRNA expression of cell cycle regulating gene (cyclin D1) and tumor suppressor genes (p53, and p21) was evaluated using real-time RT-PCR.	Zeranol	14-21	cyclin D1	Homo sapiens	78-87
21378327-7	2011	Zeranol-serum up-regulated cyclin D1 and down-regulated p53 and p21 expression in PCHBECs compared with control serum.	Zeranol	0-7	cyclin D1	Homo sapiens	27-36
21078540-5	2011	The mechanism is at least partially due to the suppressive effect of genistein both on the proper and ATO-induced Akt activation, and on the activity of NF-kappaB, and the latter correlated with the suppression of NF-kappaB regulated gene products, including cyclin D1, Bcl-xL, Bcl-2, c-myc, COX-2, and VEGF.	Genistein	69-78	cyclin D1	Homo sapiens	259-268
20798689-4	2011	The lysine residue, K33, of cyclin D1 is a key site for this newly identified regulation.	Lysine	4-10	cyclin D1	Homo sapiens	28-37
20930115-6	2011	Increases in cyclin D1 protein induced by FCS or LXA(4) were blocked by the PI3 kinase inhibitor, LY294002, and attenuated by FPR2 antagonism using Boc2.	lipoxin A4	49-55	cyclin D1	Homo sapiens	13-22
20930115-6	2011	Increases in cyclin D1 protein induced by FCS or LXA(4) were blocked by the PI3 kinase inhibitor, LY294002, and attenuated by FPR2 antagonism using Boc2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	98-106	cyclin D1	Homo sapiens	13-22
20665703-6	2011	ZD6474 inhibited cyclin D1 and cyclin E expression and induced p53 expression when combined with paclitaxel.	vandetanib	0-6	cyclin D1	Homo sapiens	17-26
21216934-6	2011	Furthermore, the MAP/ERK kinase inhibitor PD98059 partially abolished modulation of p21 and cyclin D1 expression by p53R2.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	42-49	cyclin D1	Homo sapiens	92-101
20229177-1	2011	Previous studies have demonstrated that the persistent exposure of human bronchial epithelial cells to nicotine (Nic) through nicotinic acetylcholine receptors increases cyclin D1 promoter activity and protein expression.	Nicotine	103-111	cyclin D1	Homo sapiens	170-179
21040761-0	2011	Effects of MEK and DNMT inhibitors on arsenic-treated human uroepithelial cells in relation to Cyclin-D1 and p16.	Arsenic	38-45	cyclin D1	Homo sapiens	95-104
21040761-10	2011	In addition, the Cyclin-D1 increased expression but decreased p16 expression in arsenite-treated SV-HUC-1 cells.	arsenite	80-88	cyclin D1	Homo sapiens	17-26
21040761-11	2011	However, when cells were pretreated with inhibitors (5-aza-CdR or U0126), the effects of arsenite on Cyclin-D1 and p16 expression were suppressed.	U 0126	66-71	cyclin D1	Homo sapiens	101-110
21040761-11	2011	However, when cells were pretreated with inhibitors (5-aza-CdR or U0126), the effects of arsenite on Cyclin-D1 and p16 expression were suppressed.	arsenite	89-97	cyclin D1	Homo sapiens	101-110
21040761-12	2011	Finally, these results indicated that Cyclin-D1 and p16 both might play important roles in carcinogenesis as a result of arsenic.	Arsenic	121-128	cyclin D1	Homo sapiens	38-47
21249229-5	2011	Our results show that H2O2 toxicity is associated with an increase in cell death, mitochondrial membrane depolarisation, and the expression of cyclin D1 and caspases 9 and 3.	Hydrogen Peroxide	22-26	cyclin D1	Homo sapiens	143-173
21139584-5	2011	Depletion of constitutively overexpressed cyclin D1 by GUT-70 was accompanied by p27 accumulation and decreased Rb phosphorylation.	Rubidium	112-114	cyclin D1	Homo sapiens	42-51
20229177-1	2011	Previous studies have demonstrated that the persistent exposure of human bronchial epithelial cells to nicotine (Nic) through nicotinic acetylcholine receptors increases cyclin D1 promoter activity and protein expression.	Nicotine	113-116	cyclin D1	Homo sapiens	170-179
20934245-8	2011	Also, Celastrol treatment inhibited ERalpha target gene expression, including expressions of cyclin D(1), progesterone receptor (PR), and c-Myb leading to cell cycle arrest and growth inhibition of breast cancer cells.	celastrol	6-15	cyclin D1	Homo sapiens	93-104
22113133-12	2011	The xenoestrogens diethylstilbestrol and zeranol also showed similar estrogenic effects by inhibiting miR-34b expression and by restoring the protein levels of the miR-34b targets cyclin D1 and JAG1 in MCF-7 cells.	Diethylstilbestrol	18-36	cyclin D1	Homo sapiens	180-189
22113133-12	2011	The xenoestrogens diethylstilbestrol and zeranol also showed similar estrogenic effects by inhibiting miR-34b expression and by restoring the protein levels of the miR-34b targets cyclin D1 and JAG1 in MCF-7 cells.	Zeranol	41-48	cyclin D1	Homo sapiens	180-189
20133117-0	2011	Downregulation of cyclin D1 is associated with decreased levels of p38 MAP kinases, Akt/PKB and Pak1 during chemopreventive effects of resveratrol in liver cancer cells.	Resveratrol	135-146	cyclin D1	Homo sapiens	18-27
21685708-5	2011	Docetaxel also decreased the expressions of cell cycle-related proteins, including cyclin-dependent kinase (CDK) 2, cyclin E, CDK4, cyclin D1, retinoblastoma protein, and proliferative cell nuclear antigen in PDGF-BB-stimulated VSMCs.	Docetaxel	0-9	cyclin D1	Homo sapiens	132-141
21035837-9	2011	Exposure to thioridazine induced G(0)/G(1) arrest and down-regulated the cell cycle regulator, Cyclin D1 and CDK4, and up-regulated p21, p16, and p-CDC25A.	Thioridazine	12-24	cyclin D1	Homo sapiens	95-104
21069738-8	2011	Furanodienone treatment inhibited E2-stimulation of estrogen response element (ERE)-driven reporter plasmid activity and ablated E2-targeted gene (e.g., c-Myc, Bcl-2, and cyclin D1) expression which resulted in the inhibition of cell cycle progression and cell proliferation, and in the induction of apoptosis.	furanodienone	0-13	cyclin D1	Homo sapiens	171-180
22102309-0	2011	Induction of cyclin D1 by arsenite and UVB-irradiation in human keratinocytes.	arsenite	26-34	cyclin D1	Homo sapiens	13-22
22102309-3	2011	Both epidemiological and experimental evidence indicates that arsenic and ultraviolet radiation act on signaling pathways that effect the expression of cyclin D1.	Arsenic	62-69	cyclin D1	Homo sapiens	152-161
22102309-4	2011	We have previously employed an in vitro model system of human epidermal keratinocytes to study the effects of submicromolar concentrations of sodium arsenite on cyclin D1 expression.	sodium arsenite	142-157	cyclin D1	Homo sapiens	161-170
22102309-5	2011	Here, we employed this system to demonstrate concordant cyclin D1-related induction profiles of ultraviolet B radiation and arsenite using cDNA microarray analysis.	arsenite	124-132	cyclin D1	Homo sapiens	56-65
20811392-5	2011	Keratinocyte proliferation was inhibited by STA-21 in a dose-dependent manner through downregulation of c-Myc and cyclin D1, whereas involucrin, transglutaminase 1, and keratin 10 levels were upregulated.	STA-21	44-50	cyclin D1	Homo sapiens	114-123
20133117-5	2011	Accordingly we have studied the chemopreventive effects of resveratrol on cyclin D1 expression and the signaling pathways that regulate cyclin D1 in HepG2 cells.	Resveratrol	59-70	cyclin D1	Homo sapiens	74-83
20133117-7	2011	Also, resveratrol treatment downregulated cyclin D1 as well as p38 MAP kinase, Akt and Pak1 expression and activity in HepG2 cells, suggesting that growth inhibitory activity of resveratrol is associated with the downregulation of cell proliferation and survival pathways.	Resveratrol	6-17	cyclin D1	Homo sapiens	42-51
20133117-9	2011	Thus in the present study, we report a three-dimensional relationship between the growth inhibitory effects of resveratrol - decrease in the levels of cyclin D1 - and downregulation of cell proliferation and survival pathways in HepG2 cells leading to cellular degenerative changes.	Resveratrol	111-122	cyclin D1	Homo sapiens	151-160
20926450-5	2011	On the one hand, PTEN ATP-binding mutants lose their phosphatase activity and the effect of downregulation of cyclin D1.	Adenosine Triphosphate	22-25	cyclin D1	Homo sapiens	110-119
21135252-4	2011	Under conditions of relatively quiescent AKT activity, treatment of cells with rapamycin resulted in upregulation of cyclin D1 and c-MYC nascent transcription, whereas in cells containing active AKT, exposure repressed transcription.	Sirolimus	79-88	cyclin D1	Homo sapiens	117-126
21135252-9	2011	Moreover, silencing AIP4/Itch expression or inhibiting JNK mediated AIP4 activity abrogated the rapamycin-induced effects on cyclin D1 and c-MYC promoter activities.	Sirolimus	96-105	cyclin D1	Homo sapiens	125-134
21135252-10	2011	Our findings support a role for the AKT-dependent regulation of AIP4/Itch activity in mediating the differential cyclin D1 and c-MYC transcriptional responses to rapamycin.	Sirolimus	162-171	cyclin D1	Homo sapiens	113-122
21109972-4	2011	VK2 inhibited 5-FU-induced NF-kappaB activation and cyclin D1 expression.	Fluorouracil	14-18	cyclin D1	Homo sapiens	52-61
21980390-9	2011	Resveratrol induced cell cycle arrest by up-regulating the expression of p21/CIP1, p27/KIP1 and inhibiting the expression of cyclin D1.	Resveratrol	0-11	cyclin D1	Homo sapiens	125-134
21674991-4	2011	AZD6244-resistant derivatives were refractory to AZD6244-induced cell cycle arrest and death and exhibited a marked increase in ERK1/2 (extracellular signal-regulated kinases 1 and 2) pathway signaling and cyclin D1 abundance when assessed in the absence of inhibitor.	AZD 6244	0-7	cyclin D1	Homo sapiens	206-215
21206909-2	2010	In correlative studies the impact of sorafenib on cyclin D1 and Ki67 was assessed.	Sorafenib	37-46	cyclin D1	Homo sapiens	50-59
20862710-0	2010	Activation of the p38 MAPK/Akt/ERK1/2 signal pathways is required for the protein stabilization of CDC6 and cyclin D1 in low-dose arsenite-induced cell proliferation.	arsenite	130-138	cyclin D1	Homo sapiens	108-117
20862710-8	2010	Inhibiting the activation of Akt and ERK1/2, but not p38 MAPK, decreased the ATO-induced expression of cyclin D1 protein.	Arsenic Trioxide	77-80	cyclin D1	Homo sapiens	103-112
21179458-15	2010	Inhibition of FOXO transcription factors by shRNA blocked resveratrol-induced upregulation of Bim, TRAIL, DR4, DR5, p27/KIP1 and apoptosis, and inhibition of cyclin D1 by resveratrol.	Resveratrol	58-69	cyclin D1	Homo sapiens	158-167
21179458-15	2010	Inhibition of FOXO transcription factors by shRNA blocked resveratrol-induced upregulation of Bim, TRAIL, DR4, DR5, p27/KIP1 and apoptosis, and inhibition of cyclin D1 by resveratrol.	Resveratrol	171-182	cyclin D1	Homo sapiens	158-167
20932825-8	2010	Furthermore, overexpression of the AR corepressor cyclin D1 inhibited the ability of ciglitazone to induce AR luciferase activity in C4-2 cells.	ciglitazone	85-96	cyclin D1	Homo sapiens	50-59
20932825-9	2010	Thus, our data suggest that both PPARgamma and cyclin D1 levels influence the ability of ciglitazone to differentially regulate AR signaling in androgen-independent C4-2 prostate cancer cells.	ciglitazone	89-100	cyclin D1	Homo sapiens	47-56
21144036-6	2010	When added in serum-containing media, TRG inhibited proliferation and cyclin D1 expression, but was unable to induce any apoptosis.	Troglitazone	38-41	cyclin D1	Homo sapiens	70-79
20655656-7	2010	Activated GSK-3beta then targeted cyclin D1, causing phosphorylation of cyclin D1 at Thr(286) and subsequent proteasomal degradation.	Threonine	85-88	cyclin D1	Homo sapiens	34-43
20655656-7	2010	Activated GSK-3beta then targeted cyclin D1, causing phosphorylation of cyclin D1 at Thr(286) and subsequent proteasomal degradation.	Threonine	85-88	cyclin D1	Homo sapiens	72-81
21919647-4	2011	In addition, ascorbic acid decreased expression of several Sp-regulated genes that are involved in cancer cell proliferation [hepatocyte growth factor receptor (c-Met), epidermal growth factor receptor and cyclin D1], survival (survivin and bcl-2), and angiogenesis [vascular endothelial growth factor (VEGF) and its receptors (VEGFR1 and VEGFR2)].	Ascorbic Acid	13-26	cyclin D1	Homo sapiens	206-215
21542457-6	2011	In the present study, we found that the combination of SAHA and topotecan effectively inhibited the growth of renal cancer cells by suppressing the expression of cyclin-dependent kinase (CDK) 4 and cyclin D1, and promoting retinoblastoma protein (Rb) dephosphorylation.	Vorinostat	55-59	cyclin D1	Homo sapiens	198-207
21542457-6	2011	In the present study, we found that the combination of SAHA and topotecan effectively inhibited the growth of renal cancer cells by suppressing the expression of cyclin-dependent kinase (CDK) 4 and cyclin D1, and promoting retinoblastoma protein (Rb) dephosphorylation.	Topotecan	64-73	cyclin D1	Homo sapiens	198-207
22301921-9	2011	The expression of downstream target genes of the Hedgehog pathway such as Gli1, Ptc1, CCND1 and BCL-2 were significantly decreased after 12.5 muM resveratrol treatment, which demonstrated a similar change of gene expression when Gli1 was knocked down by the RNAi technique in PANC-1 cells.	Resveratrol	146-157	cyclin D1	Homo sapiens	86-91
22301921-10	2011	Resveratrol also downregulated the expression of Gli1, Ptc1, CCND1 and BCL-2 in Gli1-overexpressed BxPC-3 cells.	Resveratrol	0-11	cyclin D1	Homo sapiens	61-66
21931726-5	2011	Vorinostat increased IGF-IR phosphorylation, produced acetylation of histone H3, up-regulated pTEN and p21 expression, and reduced p53 and cyclin D1 levels in Ishikawa cells.	Vorinostat	0-10	cyclin D1	Homo sapiens	139-148
21931726-6	2011	Vorinostat up-regulated IGF-IR and p21 expression, produced acetylation of histone H3, and down-regulated the expression of total AKT, pTEN and cyclin D1 in USPC-2 cells.	Vorinostat	0-10	cyclin D1	Homo sapiens	144-153
21695150-9	2011	Rsv also induced a S-G2/M phase arrest, accompanied by an increase on levels of pCdc2(Y15), cyclin A, E and B, and pRb (S807/811) and a decrease of cyclin D1.	Resveratrol	0-3	cyclin D1	Homo sapiens	148-157
22119840-6	2011	We also performed cyclin D1 in other 27 cases of CD (13 HV-CD and 14 plasma-cell CD) but the reported case was the only who associated "in situ" MCL.	Cadmium	49-51	cyclin D1	Homo sapiens	18-27
22069692-5	2011	At low nanomolar concentrations calyculin A induced T286 phosphorylation and degradation of cyclin D1 via the proteosome in MDA-MB-468 and MDA-MB-231 cells.	calyculin A	32-41	cyclin D1	Homo sapiens	92-101
22069692-6	2011	Cyclin D1 degradation also was dose-dependently induced by okadaic acid and catharidin, implicating a negative regulatory role for type-2A phosphatases.	Okadaic Acid	59-71	cyclin D1	Homo sapiens	0-9
22069692-6	2011	Cyclin D1 degradation also was dose-dependently induced by okadaic acid and catharidin, implicating a negative regulatory role for type-2A phosphatases.	catharidin	76-86	cyclin D1	Homo sapiens	0-9
21135252-7	2011	Forced overexpression of JunB or a conditionally active JunB-ER allele repressed cyclin D1 and c-MYC promoter activity in quiescent AKT-containing cells following rapamycin exposure.	Sirolimus	163-172	cyclin D1	Homo sapiens	81-90
20970954-6	2010	Butyrate"s cooperative effects on H3-Lysine9 acetylation and H3-Serine10 phosphorylation, and contrasting effects on di-methylation of H3-Lysine9 and H3-Lysine4 suggests that the interplay between these site-specific modifications cause distinct chromatin alterations that allow cyclin D1 and D3 induction, G1-specific cdk4, cdk6 and cdk2 downregulation, and upregulation of cdk inhibitors, p15INK4b and p21Cip1.	Butyrates	0-8	cyclin D1	Homo sapiens	279-288
20309622-6	2010	Salidroside could cause G1-phase or G2-phase arrest in different cancer cell lines, meanwhile, salidroside resulted in a decrease of CDK4, cyclin D1, cyclin B1 and Cdc2, and upregulated the levels of p27(Kip1) and p21(Cip1).	rhodioloside	95-106	cyclin D1	Homo sapiens	139-148
20309622-7	2010	Taken together, salidroside could inhibit the growth of cancer cells by modulating CDK4-cyclin D1 pathway for G1-phase arrest and/or modulating the Cdc2-cyclin B1 pathway for G2-phase arrest.	rhodioloside	16-27	cyclin D1	Homo sapiens	88-97
21084836-6	2010	Interestingly, the STAT1 serine 727 phosphorylation site and not the STAT1 tyrosine 701 site is required for cyclin D1-dependent proteosomal degradation.	Serine	25-31	cyclin D1	Homo sapiens	109-118
21084836-7	2010	Furthermore, IFN-gamma-STAT1 cyclin D1 reduction correlated with decreased amount of p-Rb Ser-795, cyclin E and increased amounts of the cell cycle inhibitors p27(Kip1) and p21(Cip1).	Serine	90-93	cyclin D1	Homo sapiens	29-38
20963488-8	2010	Bufalin induced the apoptosis and cell cycle arrest by affecting the protein expressions of Bcl-2/Bax, cytochrome c, caspase-3, PARP, p53, p21WAF1, cyclinD1, and COX-2 in A549 cells.	bufalin	0-7	cyclin D1	Homo sapiens	148-156
20814740-0	2010	Alpha-lipoic acid modulates GFAP, vimentin, nestin, cyclin D1 and MAP-kinase expression in astroglial cell cultures.	Thioctic Acid	0-17	cyclin D1	Homo sapiens	52-61
20814740-5	2010	Cyclin D1 expression increased in raceme acute-treated cultures pretreated with glutamate.	Glutamic Acid	80-89	cyclin D1	Homo sapiens	0-9
20836120-4	2010	Interestingly, these chalcone derivatives induced G(0)/G(1)-phase cell-cycle arrest, down-regulation of G(1)-phase cell-cycle regulatory proteins such as cyclin D1 and cyclin E1, and up-regulation of CDK4.	Chalcone	21-29	cyclin D1	Homo sapiens	154-163
21042767-6	2010	In addition, we found that the protein level of p27Kip1 was up-regulated and the protein level of cyclin D1 was down-regulated following LY294002 treatment in those MM cell lines.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	137-145	cyclin D1	Homo sapiens	98-107
21118500-11	2010	In addition, GS treatment significantly reduced the expression of anti-apoptotic proteins, Bcl-2, xIAP, Mcl1, survivin, cyclin D1 and c-myc, thus committing cells to apoptosis.	pregna-4,17-diene-3,16-dione	13-15	cyclin D1	Homo sapiens	120-129
20816946-6	2010	Akt1, CyclinD1, MMP-2, MMP-9 and Bcl-2 protein expression decreased, and p27 expression increased in a dose-dependent manner with miR-451 mimics oligonucleotides.	Oligonucleotides	145-161	cyclin D1	Homo sapiens	6-14
20940395-7	2010	Cyclin D1 deletion in fibroblasts or small interfering RNA-mediated reduction of endogenous cyclin D1 in colon cancer cells reduced the 5-fluorouracil-mediated DDR.	Fluorouracil	136-150	cyclin D1	Homo sapiens	0-9
20724530-10	2010	In vitro studies using HCT116 cells showed that LPA induced cyclin D1, c-Myc, and HIF-1alpha expression, which was attenuated by knockdown of LPA(2).	lysophosphatidic acid	48-51	cyclin D1	Homo sapiens	60-69
20724530-10	2010	In vitro studies using HCT116 cells showed that LPA induced cyclin D1, c-Myc, and HIF-1alpha expression, which was attenuated by knockdown of LPA(2).	lysophosphatidic acid	142-145	cyclin D1	Homo sapiens	60-69
20674553-3	2010	Treatment with antofine for 24h did not result in the induction of apoptotic cell death but moderately induced cell cycle arrest at G0/G1 phase and inhibited the expression of cyclin D1, cyclin E, and CDK4.	antofine	15-23	cyclin D1	Homo sapiens	176-185
20674553-4	2010	In addition, antofine inhibited the transcriptional activity of beta-catenin/Tcf in human colon HCT 116 cells, and the expression level of beta-catenin and cyclin D1 was also down-regulated by antofine in human colon SW480 cells.	antofine	13-21	cyclin D1	Homo sapiens	156-165
20674553-4	2010	In addition, antofine inhibited the transcriptional activity of beta-catenin/Tcf in human colon HCT 116 cells, and the expression level of beta-catenin and cyclin D1 was also down-regulated by antofine in human colon SW480 cells.	antofine	193-201	cyclin D1	Homo sapiens	156-165
20054642-6	2010	Combination of letrozole and sorafenib produced a synergistic inhibition of cell proliferation associated with an enhanced accumulation of cells in the G(0)/G(1) phase of the cell cycle and with a down-regulation of the cell cycle regulatory proteins c-myc, cyclin D1, and phospho-Rb.	Letrozole	15-24	cyclin D1	Homo sapiens	258-267
20054642-6	2010	Combination of letrozole and sorafenib produced a synergistic inhibition of cell proliferation associated with an enhanced accumulation of cells in the G(0)/G(1) phase of the cell cycle and with a down-regulation of the cell cycle regulatory proteins c-myc, cyclin D1, and phospho-Rb.	Sorafenib	29-38	cyclin D1	Homo sapiens	258-267
20940395-7	2010	Cyclin D1 deletion in fibroblasts or small interfering RNA-mediated reduction of endogenous cyclin D1 in colon cancer cells reduced the 5-fluorouracil-mediated DDR.	Fluorouracil	136-150	cyclin D1	Homo sapiens	92-101
22993626-7	2010	The mechanisms involved in the MCF-7 cell proliferation stimulated by zeranol-containing sera may include up-regulation of cyclin D1 and down-regulation of p53 and p21 expression at the mRNA and protein levels in the cells.	Zeranol	70-77	cyclin D1	Homo sapiens	123-132
21152316-1	2010	The report aims to investigate the relationship between the expression of cyclin D1 and Cyclooxgenase-2 (COX-2), thus to explore the molecular mechanisms of the antitumor efficacy of Celecoxib, a COX-2 inhibitor.	Celecoxib	183-192	cyclin D1	Homo sapiens	74-83
20878096-12	2010	Protein expression levels of cell cycle regulating proteins CDK1, CDK2, CDK4, cyclin D1, cyclin E, p19 and p27 were markedly altered by simvastatin.	Simvastatin	136-147	cyclin D1	Homo sapiens	78-87
21472344-0	2010	Leptin and zeranol up-regulate cyclin D1 expression in primary cultured normal human breast pre-adipocytes.	Zeranol	11-18	cyclin D1	Homo sapiens	31-40
21152316-6	2010	A high-dose of Celecoxib (100 mg/kg) significantly inhibited tumor growth (P &lt; 0.05), and the expression of cyclin D1 was reduced by 61%.	Celecoxib	15-24	cyclin D1	Homo sapiens	111-120
20876745-7	2010	However, testing a panel of squamous cell carcinoma of the head and neck cell lines revealed variable sensitivity to enzastaurin, which correlated significantly with baseline cyclin D1 protein expression.	enzastaurin	117-128	cyclin D1	Homo sapiens	175-184
20841488-2	2010	We have previously shown that butyrate decreases cyclin D1 and c-myc expression, each essential for intestinal tumor development, by transcriptional attenuation.	Butyrates	30-38	cyclin D1	Homo sapiens	49-58
20841488-3	2010	Here, we determined that butyrate-induced transcriptional attenuation of the cyclin D1 and c-myc genes in SW837 human colorectal adenocarcinoma cells occurs at ~100 nucleotides downstream of the transcription start site, with a similar positioning in Caco-2 cells.	Butyrates	25-33	cyclin D1	Homo sapiens	77-86
20862710-9	2010	This study reports for the first time that p38 MAPK/Akt/ERK1/2 activation is required for the protein stabilization of CDC6 in addition to cyclin D1 in ATO-induced cell proliferation and cell cycle modulation from G1 to S phase.	Arsenic Trioxide	152-155	cyclin D1	Homo sapiens	139-148
20941752-8	2010	Our results indicated that inactivation of PI-3K, Akt, or p70S6K could inhibit silica-induced overexpression of cyclin D1 and cyclin-dependent kinase 4 (CDK4) and decreased expression of E2F-4.	Silicon Dioxide	79-85	cyclin D1	Homo sapiens	112-121
20876745-10	2010	Enzastaurin modulated cyclin D1 synthesis through an Akt-regulated pathway in the former, whereas high-level CCND1 gene amplification was present in the latter.	enzastaurin	0-11	cyclin D1	Homo sapiens	22-31
20876745-11	2010	These results underscore the critical relevance of cellular signaling context in developing cancer therapies in general and suggest that enzastaurin in particular would be most effective in tumors where baseline cyclin D1 expression is low to moderate and physiologically regulated.	enzastaurin	137-148	cyclin D1	Homo sapiens	212-221
20628792-8	2010	Silibinin also targeted signaling molecules involved in CRC proliferation and survival (cyclin D1, c-Myc and survivin) as well as angiogenesis regulators (VEGF and iNOS).	Silybin	0-9	cyclin D1	Homo sapiens	88-97
20628053-10	2010	Importantly, Erk-mediated serine phosphorylation of paxillin is also required for DHT-induced prostate-specific antigen mRNA expression in LnCAP cells as well as EGF-induced cyclin D1 mRNA expression in PC3 cells, suggesting that paxillin may regulate prostate cancer proliferation by serving as a liaison between extra-nuclear kinase signaling and intra-nuclear transcriptional signals.	Serine	26-32	cyclin D1	Homo sapiens	174-183
20720195-5	2010	Inhibition of Shh signaling in hVSMCs through treatment with cyclopamine or knockdown of Gli2 results in G(1) arrest and reduced cyclin D1, cyclin E, and phosphorylated retinoblastoma (pRB) levels.	cyclopamine	61-72	cyclin D1	Homo sapiens	129-138
20699365-3	2010	We show that PD0325901, a small-molecule MEK inhibitor, decreases MEK/ERK pathway signaling and destabilizes cyclin D1, resulting in significant anticancer activity in a subset of KRAS mutant tumors in vitro and in vivo.	mirdametinib	13-22	cyclin D1	Homo sapiens	109-118
19946741-4	2010	Treatment with the gefitinib/trastuzumab combination produced, as compared with a single agent, a more prolonged blockade of AKT and MAPK activation, a more pronounced accumulation of cells in the G0/G1 phase of the cell cycle, a more significant increase in the levels of p27(kip1) and of hypophosphorylated pRb2, and a decrease in the levels of Cyclin D1 and survivin.	Gefitinib	19-28	cyclin D1	Homo sapiens	347-356
19937797-6	2010	Betulinic acid also downregulated the expression of STAT3-regulated gene products such as bcl-xL, bcl-2, cyclin D1 and survivin.	betulinic acid	0-14	cyclin D1	Homo sapiens	105-114
22993610-9	2010	The expression levels of cyclin D1 decreased and the cleavage of caspase-3 was noted in the serum-free media with sorafenib.	Sorafenib	114-123	cyclin D1	Homo sapiens	25-34
20578819-3	2010	We performed this pilot study to analyze a possible association between CCND1-3 overexpression and response to treatment with the proteasome inhibitor bortezomib, since a specific prognostic marker for bortezomib response has not been reported, but would be ideal to predict who benefits most from bortezomib in times of several potentially efficient therapeutic options.	Bortezomib	151-161	cyclin D1	Homo sapiens	72-77
20578819-3	2010	We performed this pilot study to analyze a possible association between CCND1-3 overexpression and response to treatment with the proteasome inhibitor bortezomib, since a specific prognostic marker for bortezomib response has not been reported, but would be ideal to predict who benefits most from bortezomib in times of several potentially efficient therapeutic options.	Bortezomib	202-212	cyclin D1	Homo sapiens	72-77
20578819-3	2010	We performed this pilot study to analyze a possible association between CCND1-3 overexpression and response to treatment with the proteasome inhibitor bortezomib, since a specific prognostic marker for bortezomib response has not been reported, but would be ideal to predict who benefits most from bortezomib in times of several potentially efficient therapeutic options.	Bortezomib	202-212	cyclin D1	Homo sapiens	72-77
20578819-5	2010	With CCND1 overexpression in 9/20 patients, the risk for progression after bortezomib treatment was significantly decreased (HR 0.102, 95% CI 0.021-0.498, p = 0.0048) and progression-free survival substantially prolonged (p = 0.0011).	Bortezomib	75-85	cyclin D1	Homo sapiens	5-10
20578819-6	2010	Our study is the first to suggest that overexpressed CCND1 in MM is an independent prognostic marker associated with a more durable response to bortezomib.	Bortezomib	144-154	cyclin D1	Homo sapiens	53-58
20421209-2	2010	Here we demonstrate that the non-aromatizable androgen 5-alpha-dihydrotestosterone (DHT) inhibits endogenous cyclin D1 expression, as evidenced by reduction of cyclin D1 mRNA and protein levels, and decrease of CCND1-promoter activity, in MCF-7 cells.	Dihydrotestosterone	55-82	cyclin D1	Homo sapiens	109-118
20421209-2	2010	Here we demonstrate that the non-aromatizable androgen 5-alpha-dihydrotestosterone (DHT) inhibits endogenous cyclin D1 expression, as evidenced by reduction of cyclin D1 mRNA and protein levels, and decrease of CCND1-promoter activity, in MCF-7 cells.	Dihydrotestosterone	55-82	cyclin D1	Homo sapiens	160-169
20421209-2	2010	Here we demonstrate that the non-aromatizable androgen 5-alpha-dihydrotestosterone (DHT) inhibits endogenous cyclin D1 expression, as evidenced by reduction of cyclin D1 mRNA and protein levels, and decrease of CCND1-promoter activity, in MCF-7 cells.	Dihydrotestosterone	55-82	cyclin D1	Homo sapiens	211-216
20421209-2	2010	Here we demonstrate that the non-aromatizable androgen 5-alpha-dihydrotestosterone (DHT) inhibits endogenous cyclin D1 expression, as evidenced by reduction of cyclin D1 mRNA and protein levels, and decrease of CCND1-promoter activity, in MCF-7 cells.	Dihydrotestosterone	84-87	cyclin D1	Homo sapiens	109-118
20421209-2	2010	Here we demonstrate that the non-aromatizable androgen 5-alpha-dihydrotestosterone (DHT) inhibits endogenous cyclin D1 expression, as evidenced by reduction of cyclin D1 mRNA and protein levels, and decrease of CCND1-promoter activity, in MCF-7 cells.	Dihydrotestosterone	84-87	cyclin D1	Homo sapiens	160-169
20421209-2	2010	Here we demonstrate that the non-aromatizable androgen 5-alpha-dihydrotestosterone (DHT) inhibits endogenous cyclin D1 expression, as evidenced by reduction of cyclin D1 mRNA and protein levels, and decrease of CCND1-promoter activity, in MCF-7 cells.	Dihydrotestosterone	84-87	cyclin D1	Homo sapiens	211-216
20421209-3	2010	The DHT-dependent inhibition of CCND1 gene activity requires the involvement and the integrity of the androgen receptor (AR) DNA-binding domain.	Dihydrotestosterone	4-7	cyclin D1	Homo sapiens	32-37
20836976-7	2010	Study of signal molecules through mRNA expressions revealed that NHMC caused down-regulation of cyclin-D1, proliferating cell nuclear antigen (PCNA), survivin and Stat-3, and up-regulation of p53 and caspase-3, that in turn induced a greater number of apoptosis vis-a-vis unencapsulated HMC.	nhmc	65-69	cyclin D1	Homo sapiens	96-105
20435036-3	2010	Using arsenic trioxide-responsive KU7 and non-responsive 253JB-V bladder cancer cells as models, we show that in KU7 cells, &lt; or =5 microM arsenic trioxide decreased Sp1, Sp3 and Sp4 and several Sp-dependent genes and responses including cyclin D1, epidermal growth factor receptor, bcl-2, survivin and vascular endothelial growth factor, whereas at concentrations up to 15 microM, minimal effects were observed in 253JB-V cells.	Arsenic Trioxide	142-158	cyclin D1	Homo sapiens	241-250
19436953-4	2010	TMPP treatment effected a reduction in both cell cycle progression signals (FoxM1, KIS, Cdc25B, Cyclin D1, Cyclin A, and Aurora-B) and tumor cell survival (p27(Kip1) and p21(Cip1)), as well as induced the activation of caspase-3 and -9.	2,3,4-tribromo-3-methyl-1-phenylphospholane 1-oxide	0-4	cyclin D1	Homo sapiens	96-105
20110442-9	2010	Additionally, Mbeta-CD and caveolin-1 siRNA decreased the expression levels of cyclin D1 and cyclin E, and the proliferation index [(S + G2/M)/(G0/G1 + S + G2/M)] of ES cells.	methyl-beta-cyclodextrin	14-22	cyclin D1	Homo sapiens	79-88
20813708-6	2010	The expression of cyclin D1 in metformin-treated cells were lowered significantly as compared with that in the control cells.	Metformin	31-40	cyclin D1	Homo sapiens	18-27
20813708-7	2010	Telomerase activity was also decreased significantly in the cells after treatment with 5 mmol/L metformin for 72 h. CONCLUSION: Metformin can inhibit the growth of SW-480 cells mainly by blocking the cell cycle at G0/G1, down-regulating the expression of cyclin D1 and decreasing telomerase activity.	Metformin	96-105	cyclin D1	Homo sapiens	255-264
20813708-7	2010	Telomerase activity was also decreased significantly in the cells after treatment with 5 mmol/L metformin for 72 h. CONCLUSION: Metformin can inhibit the growth of SW-480 cells mainly by blocking the cell cycle at G0/G1, down-regulating the expression of cyclin D1 and decreasing telomerase activity.	Metformin	128-137	cyclin D1	Homo sapiens	255-264
21029618-15	2010	The expression of genes of cyclinD1, A20 and MMP-9, were all decreased by the treatment of lanthanum chloride in a dose-dependent manner.	lanthanum chloride	91-109	cyclin D1	Homo sapiens	27-35
21029618-16	2010	CONCLUSION: Lanthanum chloride can inhibit the proliferation and migration of cervical cancer cells, and induce apoptosis by down-regulating cyclinD1, A20, and MMP-9 expressions in vitro.	lanthanum chloride	12-30	cyclin D1	Homo sapiens	141-149
20737317-1	2010	OBJECTIVE: To study the effects of NS398, a selective cyclooxygenase-2 (COX-2) inhibitor, on the transcription and translation of BCL-3 and its regulatory gene cyclin D1 in colon cancer cell line SW480.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	35-40	cyclin D1	Homo sapiens	160-169
20737317-8	2010	When the concentration of NS398 reached 50 micromol/L, the differences in the expression of cyclin D1 mRNA and protein were statistically significant (P&lt;0.05).	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	26-31	cyclin D1	Homo sapiens	92-101
20668652-8	2010	Furthermore, we show that the KRIT1-dependent maintenance of low ROS levels facilitates the downregulation of cyclin D1 expression required for cell transition from proliferative growth to quiescence.	Reactive Oxygen Species	65-68	cyclin D1	Homo sapiens	110-119
19806481-4	2010	We analyzed the expression of cyclinD1 and p16 antigens in a series of 42 MB with various grades and pathological types by immunohistochemical analysis on paraffin-embedded sections.	Paraffin	155-163	cyclin D1	Homo sapiens	30-38
20628002-0	2010	Cryptotanshinone inhibits cancer cell proliferation by suppressing Mammalian target of rapamycin-mediated cyclin D1 expression and Rb phosphorylation.	cryptotanshinone	0-16	cyclin D1	Homo sapiens	106-115
21113238-8	2010	Mirk depletion increased cyclin D1 levels in 3 of 4 ovarian cancer cell lines, implying that some Mirk depleted cells could more readily enter cycle, potentially increasing their sensitivity to cisplatin.	Cisplatin	194-203	cyclin D1	Homo sapiens	25-34
20596608-6	2010	Pre-treatment of NS3 protein expressing cells with ERK inhibitor, PD98059, blocked the activation of AP-1 and NF-kappaB, and inhibited cyclin D1 expression and cell proliferation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	66-73	cyclin D1	Homo sapiens	135-144
21152226-5	2010	RESULTS: The expressions of CDK2 and cyclin D1 for different concentrations of DCA in normal colonocytes and colon cancer cells were similar, but the expressions of cyclin E and A were significantly different.	Deoxycholic Acid	79-82	cyclin D1	Homo sapiens	37-46
20647339-8	2010	Tumor growth inhibition is accompanied by significant reduction in activation of nuclear factor-kappaB, as well as significant reduction in expression of matrix metalloproteinase-9 and cyclin D1, in xenografts treated with NanoCurc and gemcitabine.	gemcitabine	236-247	cyclin D1	Homo sapiens	185-194
20488920-2	2010	Treatment of Panc1, Panc28, and L3.6pL pancreatic cancer cells with low micromolar concentrations of CDDO or CDDO-Me resulted in growth inhibition, induction of apoptosis, and down-regulation of cyclin D1, survivin, vascular endothelial growth factor (VEGF), and its receptor (VEGFR2).	2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid	101-105	cyclin D1	Homo sapiens	195-204
20488920-2	2010	Treatment of Panc1, Panc28, and L3.6pL pancreatic cancer cells with low micromolar concentrations of CDDO or CDDO-Me resulted in growth inhibition, induction of apoptosis, and down-regulation of cyclin D1, survivin, vascular endothelial growth factor (VEGF), and its receptor (VEGFR2).	bardoxolone methyl	109-116	cyclin D1	Homo sapiens	195-204
20723296-0	2010	[Celastrol down-regulates expression of P-Akt and cyclin D1 in HL-60 cells and induces apoptosis].	celastrol	1-10	cyclin D1	Homo sapiens	50-59
20723296-5	2010	The Celastrol suppressed the expression of pAkt and Cyclin D1 in HL-60 cells to a varying degree which showed obvious concentration-and time-dependent manners.	celastrol	4-13	cyclin D1	Homo sapiens	52-61
20302909-5	2010	Overexpression of hERalpha46 in MCF-7 cells reduced estradiol (E(2))-stimulated endogenous pS2, cyclin D1, nuclear respiratory factor-1 (NRF-1), and progesterone receptor transcription.	Estradiol	52-61	cyclin D1	Homo sapiens	96-105
20302909-5	2010	Overexpression of hERalpha46 in MCF-7 cells reduced estradiol (E(2))-stimulated endogenous pS2, cyclin D1, nuclear respiratory factor-1 (NRF-1), and progesterone receptor transcription.	Estradiol	63-67	cyclin D1	Homo sapiens	96-105
20642839-7	2010	SFN induced the expression of p21/CIP1 and p27/KIP1, and inhibited the expression of cyclin D1.	sulforaphane	0-3	cyclin D1	Homo sapiens	85-94
19908231-10	2010	As compared to vehicle control, resveratrol also suppressed the NF-kappaB activation and expression of cyclin D1, COX-2, ICAM-1, MMP-9 and survivin.	Resveratrol	32-43	cyclin D1	Homo sapiens	103-112
20551055-4	2010	In this report, we show that CAFs respond to physiologic concentrations of 17beta-estradiol (E2) by rapidly inducing extracellular signal-regulated kinase phosphorylation and immediate early gene expression, including c-fos and connective tissue growth factor, and cyclin D1.	Estradiol	75-91	cyclin D1	Homo sapiens	265-274
20657652-4	2010	METHODOLOGY/PRINCIPAL FINDINGS: In this study, we show that DCB-3503 suppresses the expression of pro-oncogenic or pro-survival proteins with short half-lives, including cyclin D1, survivin, beta-catenin, p53, and p21, without decreasing their mRNA levels.	DCB 3503	60-68	cyclin D1	Homo sapiens	170-179
20618968-2	2010	In terms of side effects, they are known to be associated with osteonecrosis of the jaw (BONJ).The objective of this study was to evaluate the effect of bisphosphonates on osteoblast proliferation by cell count and gene expression analysis of cyclin D1 in vitro.	Diphosphonates	153-168	cyclin D1	Homo sapiens	243-252
20568314-4	2010	These results suggest that D609 inhibits the proliferation of neural progenitor cells by reducing the cyclin D1 content resulting in decreased phosphorylation of retinoblastoma and subsequent inhibition of cell division.	tricyclodecane-9-yl-xanthogenate	27-31	cyclin D1	Homo sapiens	102-111
20618968-9	2010	Zolendronate led to a lower cyclin D1 gene expression after 10 days.	zolendronate	0-12	cyclin D1	Homo sapiens	28-37
20683025-5	2010	Growth suppression by gamma-tocotrienol was accompanied by changes in the levels of cell cycle regulatory proteins, notably, Rb/E2F complex, cyclin D1/cdk4 and cyclin B1/cdk1, as exemplified by loss of cyclin D1, inhibition of specific Rb phosphorylation (pRb-p at Thr821), and by the time- and dose-dependent increase in the expression of NQO2.	plastochromanol 8	22-39	cyclin D1	Homo sapiens	141-150
20683025-5	2010	Growth suppression by gamma-tocotrienol was accompanied by changes in the levels of cell cycle regulatory proteins, notably, Rb/E2F complex, cyclin D1/cdk4 and cyclin B1/cdk1, as exemplified by loss of cyclin D1, inhibition of specific Rb phosphorylation (pRb-p at Thr821), and by the time- and dose-dependent increase in the expression of NQO2.	plastochromanol 8	22-39	cyclin D1	Homo sapiens	202-211
20061362-10	2010	In HT-29 cells, pterostilbene reduced the protein levels of beta-catenin, cyclin D1 and c-MYC, altered the cellular localization of beta-catenin and inhibited the phosphorylation of p65.	pterostilbene	16-29	cyclin D1	Homo sapiens	74-83
20307652-8	2010	Accumulation of cyclin D1 protein levels in replated cells was suppressed in cells treated with 4-Cl-BQ.	4-cl-bq	96-103	cyclin D1	Homo sapiens	16-25
20651819-5	2010	infusion of the PPARgamma agonist ciglitazone, beginning 5 days before and continuing through 1 day after MCAO, reduced infarct size and cyclin D1 expression in the peri-infarct cortical region.	ciglitazone	34-45	cyclin D1	Homo sapiens	137-146
20651819-6	2010	Furthermore, primary cortical neurons treated with ciglitazone showed suppressed expression of cyclin D1 in response to hypoxia-reoxygenation.	ciglitazone	51-62	cyclin D1	Homo sapiens	95-104
20307652-9	2010	Pretreatment of quiescent cells with polyethylene glycol-conjugated superoxide dismutase and catalase suppressed 4-Cl-BQ induced increase in ROS levels, which was consistent with an increase in cyclin D1 accumulation, and entry into S phase.	Polyethylene Glycols	37-56	cyclin D1	Homo sapiens	194-203
20307652-9	2010	Pretreatment of quiescent cells with polyethylene glycol-conjugated superoxide dismutase and catalase suppressed 4-Cl-BQ induced increase in ROS levels, which was consistent with an increase in cyclin D1 accumulation, and entry into S phase.	4-cl-bq	113-120	cyclin D1	Homo sapiens	194-203
20307652-9	2010	Pretreatment of quiescent cells with polyethylene glycol-conjugated superoxide dismutase and catalase suppressed 4-Cl-BQ induced increase in ROS levels, which was consistent with an increase in cyclin D1 accumulation, and entry into S phase.	Reactive Oxygen Species	141-144	cyclin D1	Homo sapiens	194-203
20232305-0	2010	High glucose regulates cyclin D1/E of human mesenchymal stem cells through TGF-beta1 expression via Ca2+/PKC/MAPKs and PI3K/Akt/mTOR signal pathways.	Glucose	5-12	cyclin D1	Homo sapiens	23-32
20378717-8	2010	beta-Escin also down-regulated the expression of STAT3-regulated gene products, such as cyclin D1, Bcl-2, Bcl-xL, survivin, Mcl-1, and vascular endothelial growth factor.	Escin	0-10	cyclin D1	Homo sapiens	88-97
20394812-7	2010	Pre-treatment of cells with a proteasome inhibitor (MG132) suppressed PCB-153 induced decrease in cyclin D1 protein levels.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	52-57	cyclin D1	Homo sapiens	98-107
20394812-8	2010	Interestingly, suppression in cyclin D1 accumulation was associated with an increase in cellular glucose consumption, and hexokinase II and pyruvate kinase protein levels.	Glucose	97-104	cyclin D1	Homo sapiens	30-39
20420878-0	2010	p52-Bcl3 complex promotes cyclin D1 expression in BEAS-2B cells in response to low concentration arsenite.	arsenite	97-105	cyclin D1	Homo sapiens	26-35
20420878-3	2010	It is also known that arsenite exposure enhances cyclin D1 expression, which involves NF-kappaB activation.	arsenite	22-30	cyclin D1	Homo sapiens	49-58
20420878-5	2010	This study was designed to characterize the underlying mechanism of induced cell growth and cyclin D1 expression in response to low concentration sodium arsenic (NaAsO(2)) exposure through the NF-kappaB pathway.	sodium arsenic	146-160	cyclin D1	Homo sapiens	92-101
20420878-5	2010	This study was designed to characterize the underlying mechanism of induced cell growth and cyclin D1 expression in response to low concentration sodium arsenic (NaAsO(2)) exposure through the NF-kappaB pathway.	naaso	162-167	cyclin D1	Homo sapiens	92-101
20420878-7	2010	To profile the canonical and non-canonical NF-kappaB pathways involved in cell growth and cyclin D1 expression induced by low concentration arsenite, the NF-kappaB-specific inhibitor-phenethyl caffeate (CAPE) and NF-kappaB2 mRNA target sequences were used, and cyclin D1 expression in BEAS-2B cells was assessed.	arsenite	140-148	cyclin D1	Homo sapiens	90-99
20420878-7	2010	To profile the canonical and non-canonical NF-kappaB pathways involved in cell growth and cyclin D1 expression induced by low concentration arsenite, the NF-kappaB-specific inhibitor-phenethyl caffeate (CAPE) and NF-kappaB2 mRNA target sequences were used, and cyclin D1 expression in BEAS-2B cells was assessed.	arsenite	140-148	cyclin D1	Homo sapiens	261-270
20420878-7	2010	To profile the canonical and non-canonical NF-kappaB pathways involved in cell growth and cyclin D1 expression induced by low concentration arsenite, the NF-kappaB-specific inhibitor-phenethyl caffeate (CAPE) and NF-kappaB2 mRNA target sequences were used, and cyclin D1 expression in BEAS-2B cells was assessed.	caffeic acid phenethyl ester	203-207	cyclin D1	Homo sapiens	90-99
20420878-8	2010	Our results demonstrated that exposure to low concentration arsenite enhanced BEAS-2B cells growth and cyclin D1 mRNA and protein expression.	arsenite	60-68	cyclin D1	Homo sapiens	103-112
20420878-9	2010	Activation and nuclear localization of p52 and Bcl3 in response to low concentration arsenite indicated that the non-canonical NF-kappaB pathway was involved in arsenite-induced cyclin D1 expression.	arsenite	85-93	cyclin D1	Homo sapiens	178-187
20420878-9	2010	Activation and nuclear localization of p52 and Bcl3 in response to low concentration arsenite indicated that the non-canonical NF-kappaB pathway was involved in arsenite-induced cyclin D1 expression.	arsenite	161-169	cyclin D1	Homo sapiens	178-187
20420878-11	2010	The up-regulation of cyclin D1 mediated by the p52-Bcl3 complex in response to low concentration arsenite might be important in assessing the health risk of low concentration arsenite and understanding the mechanisms of the harmful effects of arsenite.	arsenite	97-105	cyclin D1	Homo sapiens	21-30
20420878-11	2010	The up-regulation of cyclin D1 mediated by the p52-Bcl3 complex in response to low concentration arsenite might be important in assessing the health risk of low concentration arsenite and understanding the mechanisms of the harmful effects of arsenite.	arsenite	175-183	cyclin D1	Homo sapiens	21-30
20420878-11	2010	The up-regulation of cyclin D1 mediated by the p52-Bcl3 complex in response to low concentration arsenite might be important in assessing the health risk of low concentration arsenite and understanding the mechanisms of the harmful effects of arsenite.	arsenite	175-183	cyclin D1	Homo sapiens	21-30
20550649-8	2010	CONCLUSIONS: To generalize our findings, LA-12 induced degradation of other Hsp90 client proteins such as Cyclin D1 and estrogen receptor was shown and proved as more efficient in comparison with cisplatin.	UNII-37WM0V5E17	41-46	cyclin D1	Homo sapiens	106-115
20338923-8	2010	Knockdown of cyclin D1 in HuH7 cells produced reciprocal changes in steroid metabolism genes compared with cyclin D1 overexpression in mouse liver.	Steroids	68-75	cyclin D1	Homo sapiens	13-22
20210794-8	2010	Analysis of cell cycle regulatory proteins revealed that rosiglitazone decreased the protein levels of proliferating cell nuclear antigen, pRb, cyclin D1, cyclin D2 and Cdk4 but increased the levels of p21 and p27 in a dose-dependent manner.	Rosiglitazone	57-70	cyclin D1	Homo sapiens	144-153
19636701-0	2010	Co-amplification of CCND1 and EMSY is associated with an adverse outcome in ER-positive tamoxifen-treated breast cancers.	Tamoxifen	88-97	cyclin D1	Homo sapiens	20-25
19636701-4	2010	Both CCND1 and EMSY amplifications were associated with a significantly worse outcome in ER-positive patients treated with tamoxifen only, in contrast to nonamplified tumors (P = 8.55 x 10(-4) and P = 8.35 x 10(-5), respectively).	Tamoxifen	123-132	cyclin D1	Homo sapiens	5-10
19636701-8	2010	In summary, co-amplification of CCND1 and EMSY identified a poor prognostic subset of ER-positive tamoxifen-treated patients.	Tamoxifen	98-107	cyclin D1	Homo sapiens	32-37
20484175-4	2010	In normal-appearing bronchial epithelium, positive staining for cyclin D1 was observed in 23% of cases in the beta-carotene group and 0% of cases in the placebo group (based on only 3 of 13 versus 0 of 11 cases staining positively, however; P = 0.04), with no differences in expression noted in lung tumor tissue (P = 0.48).	beta Carotene	110-123	cyclin D1	Homo sapiens	64-73
19908231-7	2010	Resveratrol inhibited the proliferation of 4 different human PaCa cell lines, synergized the apoptotic effects of gemcitabine, inhibited the constitutive activation of NF-kappaB and expression of bcl-2, bcl-xL, COX-2, cyclin D1 MMP-9 and VEGF.	Resveratrol	0-11	cyclin D1	Homo sapiens	218-227
20171761-7	2010	Our findings suggested the phenanthrylphenol-PBD conjugate 4c, which is a cyclin D1 inhibitor could be considered as a promising lead compound against breast cancer for further investigation.	phenanthrylphenol-pbd	27-48	cyclin D1	Homo sapiens	74-83
20429769-3	2010	Both azadirachtin and nimbolide significantly suppressed the viability of HeLa cells in a dose-dependent manner by inducing cell cycle arrest at G0/G1 phase accompanied by p53-dependent p21 accumulation and down-regulation of the cell cycle regulatory proteins cyclin B, cyclin D1 and PCNA.	azadirachtin	5-17	cyclin D1	Homo sapiens	271-280
20429769-3	2010	Both azadirachtin and nimbolide significantly suppressed the viability of HeLa cells in a dose-dependent manner by inducing cell cycle arrest at G0/G1 phase accompanied by p53-dependent p21 accumulation and down-regulation of the cell cycle regulatory proteins cyclin B, cyclin D1 and PCNA.	nimbolide	22-31	cyclin D1	Homo sapiens	271-280
20379950-3	2010	In the present study, we have demonstrated that the proliferative effect of 17beta-estradiol involves the induction of both cell cycle gene expressions, c-myc and cyclin D1.	Estradiol	76-92	cyclin D1	Homo sapiens	163-172
20109579-8	2010	Furthermore, we show that though the level of methyltransferases enzymes was increased, the status of H3 three-methylation at lysine 27 (H3K27me(3)), associated with gene repression on the promoter of Cyclin D1, was lower.	Lysine	126-132	cyclin D1	Homo sapiens	201-210
20186868-5	2010	Western blot analysis on DU145 cells treated with compounds 7 and 9 demonstrated that 7-azaisoindigo derivatives could decrease the level of CDK2 activity (phosphorylation) and the expression of cyclin D1, and increase the expression of endogenous cyclin-dependent inhibitor p27.	7-azaisoindigo	86-100	cyclin D1	Homo sapiens	195-204
20178884-8	2010	Treatment with trichostatin A or apicidine suppressed the proliferation in all cell lines examined, in association with increased expression of p21 and down-regulation of cyclin D1 and cyclin A expression.	trichostatin A	15-29	cyclin D1	Homo sapiens	171-180
20178884-8	2010	Treatment with trichostatin A or apicidine suppressed the proliferation in all cell lines examined, in association with increased expression of p21 and down-regulation of cyclin D1 and cyclin A expression.	apicidine	33-42	cyclin D1	Homo sapiens	171-180
19369047-6	2010	DHA supplementation resulted in down-regulation of ERalpha expression (particularly in the extranuclear fraction), a reduction in phosphorylated MAPK, a decrease in cyclin D1 levels and an inhibition in cell viability.	Docosahexaenoic Acids	0-3	cyclin D1	Homo sapiens	165-174
19369047-9	2010	We propose that breast cancer cell proliferation is inhibited by DHA through proteasome-dependent degradation of ERalpha, reduced cyclin D1 expression and inhibition of MAPK signaling.	Docosahexaenoic Acids	65-68	cyclin D1	Homo sapiens	130-139
19396459-6	2010	Our studies from pancreatic cancer cell lines indicate that targeted inhibition of hedgehog signaling by Smo signaling inhibitor KAAD-cyclopamine causes hedgehog target gene expression (Gli1) suppression, induces P21 expression and G1 cell population, and reduced expression of Cyclin D1 and IGF2.	3-keto-N-aminoethylaminoethylcaproyldihydrocinnamoyl cyclopamine	129-145	cyclin D1	Homo sapiens	278-287
20206645-7	2010	The expression profiles seen with p,p"-DDE showed some similarities with E2, but overall, p,p"-DDE was a fairly weak transcriptional inducer of TFF1, ER, PR, BRCA1 and CCND1.	Dichlorodiphenyl Dichloroethylene	90-98	cyclin D1	Homo sapiens	168-173
20406843-6	2010	Both inhibitory effects of KW-2478 on such transcriptional and translational pathways were shown to reduce c-Maf and cyclin D1 expression.	KW-2478	27-34	cyclin D1	Homo sapiens	117-126
20214871-0	2010	Dose-dependent changes in cyclin D1 in response to 4-nitroquinoline 1-oxide-induced DNA damage.	4-Nitroquinoline-1-oxide	51-75	cyclin D1	Homo sapiens	26-35
20214871-2	2010	In this study, we show that the protein levels of cyclin D1 and the CDK inhibitor, p21(CIP1), respond in a dose-dependent manner to the DNA damaging agent, 4-nitroquinoline 1-oxide (4NQO).	4-Nitroquinoline-1-oxide	156-180	cyclin D1	Homo sapiens	50-59
20214871-2	2010	In this study, we show that the protein levels of cyclin D1 and the CDK inhibitor, p21(CIP1), respond in a dose-dependent manner to the DNA damaging agent, 4-nitroquinoline 1-oxide (4NQO).	4-Nitroquinoline-1-oxide	182-186	cyclin D1	Homo sapiens	50-59
20082305-2	2010	Genistein, a tyrosine protein kinase inhibitor, decreased the intracellular Ca(2+) and attenuated cell proliferation and DNA synthesis through the beta-catenin and cyclin D1 pathway in human umbilical CD105-positive cells.	Genistein	0-9	cyclin D1	Homo sapiens	164-173
20454513-4	2010	Other studies, therefore, were performed only in SW480 cells where silibinin significantly decreased beta-catenin-dependent T-cell factor-4 (TCF-4) transcriptional activity and protein expression of beta-catenin target genes such as c-Myc and cyclin D1.	Silybin	67-76	cyclin D1	Homo sapiens	243-252
20454513-7	2010	Analyses of xenografts showed that similar to cell culture findings, silibinin decreases proliferation and expression of beta-catenin, cyclin D1, c-Myc, and CDK8 but induces apoptosis in vivo.	Silybin	69-78	cyclin D1	Homo sapiens	135-144
20106947-8	2010	We provide evidence for the first time that nicotine strongly activated Stat3, leading to Cyclin D1 overexpression, cell cycle perturbations, and chemoresistance.	Nicotine	44-52	cyclin D1	Homo sapiens	90-99
20101207-6	2010	Tax binds the cyclin D1 promoter-proximal cyclic AMP response element (CRE) in the presence of phosphorylated CREB (pCREB) in vitro, and together the Tax-pCREB complex recruits the cellular co-activator p300 to the promoter through this unconventional Tax-responsive element.	Cyclic AMP	42-52	cyclin D1	Homo sapiens	14-23
20530440-2	2010	A polymorphism in the CCND1 gene, G870A, results in an aberrantly spliced protein (cyclin D1b) lacking the Thr-286 phosphorylation site necessary for nuclear export.	Threonine	107-110	cyclin D1	Homo sapiens	22-27
20407865-9	2010	The protein levels of PKCalpha and cyclin D1 in PASMCs were significantly increased in smoker group and COPD group as compared with non-smoker group (P&lt;0.01).	pasmcs	48-54	cyclin D1	Homo sapiens	35-44
20407865-10	2010	The mRNA expressions of PKCalpha and cyclin D1 in PASMCs were significantly elevated in smoker group and COPD group as compared with non-smoker group (P&lt;0.01).	pasmcs	50-56	cyclin D1	Homo sapiens	37-46
20407865-14	2010	In conclusion, increased expressions of PKCalpha and cyclin D1 might be involved in the pathogenesis of abnormal proliferation of PASMCs in smokers with normal lung function and smokers with mild to moderate COPD.	pasmcs	130-136	cyclin D1	Homo sapiens	53-62
20470206-11	2010	Further, sulindac treatment reduced c-myc and cyclin D1 levels in 8505-C and KTC-1 cells, but had no effect in TPC-1 cells.	Sulindac	9-17	cyclin D1	Homo sapiens	46-55
20504360-5	2010	RESULTS: Resveratrol (100-150 microM) exhibited anti-proliferative properties in HT-29 cells even after IGF-1 exposure by arresting G0/G1-S phase cell cycle progression through p27 stimulation and cyclin D1 suppression.	Resveratrol	9-20	cyclin D1	Homo sapiens	197-206
19876716-9	2010	Consistent with growth inhibition and apoptosis induction, icaritin decreased cyclin D1 and CDK4 expression and increased Bax/Bcl-2 ratio in human PSMCs.	icaritin	59-67	cyclin D1	Homo sapiens	78-87
20426528-9	2010	Furthermore, the authors assessed the role of cyclin D1 in PKC alpha-induced HASMC proliferation by transfection with a recombinant cyclin D1 antisense construct.	hasmc	77-82	cyclin D1	Homo sapiens	46-55
20426528-10	2010	The activation of PKC alpha with phorbol myristate acetate (PMA), a PKC activator, up-regulated cyclin D1 expression and increased the proliferation of passively sensitized HASMCs.	Tetradecanoylphorbol Acetate	33-58	cyclin D1	Homo sapiens	96-105
20426528-10	2010	The activation of PKC alpha with phorbol myristate acetate (PMA), a PKC activator, up-regulated cyclin D1 expression and increased the proliferation of passively sensitized HASMCs.	Tetradecanoylphorbol Acetate	60-63	cyclin D1	Homo sapiens	96-105
20426528-12	2010	In addition, the authors showed that transfection with antisense cyclin D1 abolished PMA-induced G1/S progression and HASMC proliferation.	Tetradecanoylphorbol Acetate	85-88	cyclin D1	Homo sapiens	65-74
20426528-12	2010	In addition, the authors showed that transfection with antisense cyclin D1 abolished PMA-induced G1/S progression and HASMC proliferation.	hasmc	118-123	cyclin D1	Homo sapiens	65-74
20426528-13	2010	These results demonstrate that PKC alpha promotes the proliferation of HASMCs sensitized with atopic asthmatic serum via up-regulation of cyclin D1 expression.	hasmcs	71-77	cyclin D1	Homo sapiens	138-147
20372799-3	2010	We found that hemin regulates cyclin D1 and IGF-1R proteins and insulin-like growth factor-1 gene expression through STAT5b in breast cancer cells.	Hemin	14-19	cyclin D1	Homo sapiens	30-39
20372799-9	2010	These data indicate that hemin inhibits the cyclin D1 and IGF-1 expression via STAT5b under hypoxia in ERalpha-negative breast cancer cells.	Hemin	25-30	cyclin D1	Homo sapiens	44-53
20372799-10	2010	These findings are valuable toward understanding the role of hemin-induced inhibition of cyclin D1 and IGF-1 expression under hypoxia in invasive and metastatic breast cancer.	Hemin	61-66	cyclin D1	Homo sapiens	89-98
20139705-6	2010	ZD6474 inhibited cell proliferation in a dose-dependent manner, by blocking cell progression at the G(0)-G(1) stage, through downregulation of expression of cyclin D1 and cyclin E. In vitro, ZD6474 inhibited growth factor-induced phosphorylation of EGFR, VEGFR-2, MAPK and Akt.	vandetanib	0-6	cyclin D1	Homo sapiens	157-166
20139705-6	2010	ZD6474 inhibited cell proliferation in a dose-dependent manner, by blocking cell progression at the G(0)-G(1) stage, through downregulation of expression of cyclin D1 and cyclin E. In vitro, ZD6474 inhibited growth factor-induced phosphorylation of EGFR, VEGFR-2, MAPK and Akt.	vandetanib	191-197	cyclin D1	Homo sapiens	157-166
19922527-4	2010	As we have previously reported, alcohol and one of its metabolites, acetone, induce keratinocyte proliferation and increase the mRNA levels of genes characteristic for proliferating keratinocytes, such as alpha5 integrin, cyclin D1 and keratinocyte growth factor receptor.	Alcohols	32-39	cyclin D1	Homo sapiens	222-231
19922527-4	2010	As we have previously reported, alcohol and one of its metabolites, acetone, induce keratinocyte proliferation and increase the mRNA levels of genes characteristic for proliferating keratinocytes, such as alpha5 integrin, cyclin D1 and keratinocyte growth factor receptor.	Acetone	68-75	cyclin D1	Homo sapiens	222-231
20646665-11	2010	Western blot assay indicated that dihydroartemisinin downregulated expression of nuclear P65, and combined treatment not only downregulated the expression of Cyclin D1, Bcl-xL and Bcl-2 while upregulated Bax, thus reduced the Bcl-2/Bax ratio, but also increased the caspase-3 activation, all of which increased apoptosis in both BxPC-3 and Panc-1 cells.	artenimol	34-52	cyclin D1	Homo sapiens	158-167
20093493-8	2010	In addition, NAC reduced PCNA and cyclin D1 immunostainings, as well as thyroid weight, whereas 15dPGJ2 influenced neither thyroid weight nor cell proliferation.	Acetylcysteine	13-16	cyclin D1	Homo sapiens	34-43
19857041-3	2010	Here we identify that Wnt2/beta-catenin signaling pathway is activated in ESCC cells, and sodium nitroprusside (SNP) and siRNA against beta-catenin not only inhibit the expressions of beta-catenin and its major downstream effectors including c-myc and cyclin D1, but induce cell cycle arrest and apoptosis, suggesting that Wnt2/beta-catenin pathway may be a potential molecular target for ESCC therapy.	Nitroprusside	90-110	cyclin D1	Homo sapiens	252-261
20179208-11	2010	We also identify many proteins related to cytoskeletal function, biomolecular synthesis, organelle biogenesis, and calcium regulation whose levels of expression change concomitant with decreased cell motility induced by decreased cyclin D1 and cyclin D1-cdk4/6 activities.	Calcium	115-122	cyclin D1	Homo sapiens	230-239
20179208-11	2010	We also identify many proteins related to cytoskeletal function, biomolecular synthesis, organelle biogenesis, and calcium regulation whose levels of expression change concomitant with decreased cell motility induced by decreased cyclin D1 and cyclin D1-cdk4/6 activities.	Calcium	115-122	cyclin D1	Homo sapiens	244-260
20068008-6	2010	In the absence of disease, 8-Br-cAMP down-regulated progression through the cell cycle via a decrease in cyclin D1, cyclin-dependent kinase 6, and cell division cycle 2 and an increase in cyclin-dependent kinase inhibitor 1A.	8-Bromo Cyclic Adenosine Monophosphate	27-36	cyclin D1	Homo sapiens	105-114
20025076-6	2010	Furthermore, curcumin reduced the levels of beta-catenin, the activate/phosphorylated form of Akt and NF-kappaB, which led to downregulating the three common key effectors, namely C-myc, N-myc, and Cyclin D1.	Curcumin	13-21	cyclin D1	Homo sapiens	198-207
20197399-5	2010	AnAc 24:1(omega5) inhibited estradiol (E(2))-induced estrogen response element (ERE) reporter activity and transcription of the endogenous E(2) target genes pS2, cyclin D1, and cathepsin D in MCF-7 cells.	Estradiol	28-37	cyclin D1	Homo sapiens	162-171
20124472-5	2010	We further showed that signal transducer and activator of transcription-3 (STAT3), the target of cucurbitacin-I inhibition, was hyperactivated in NF1-deficient primary astrocytes and neural stem cells, mouse glioma cells, and human MPNST cells through Ser(727) phosphorylation, leading to increased cyclin D1 expression.	cucurbitacin I	97-111	cyclin D1	Homo sapiens	299-308
20074550-3	2010	Stimulating A549 cells with lithium chloride (LiCl) resulted in accumulation of beta-catenin and up-regulation of a typical Wnt target gene cyclin D1.	Lithium Chloride	28-44	cyclin D1	Homo sapiens	140-149
20074550-3	2010	Stimulating A549 cells with lithium chloride (LiCl) resulted in accumulation of beta-catenin and up-regulation of a typical Wnt target gene cyclin D1.	Lithium Chloride	46-50	cyclin D1	Homo sapiens	140-149
19940156-5	2010	Cyclin D1, a major target of ERalpha, is transcriptionally up-regulated by IKKepsilon in a phospho-ERalpha-Ser-167-dependent manner.	Serine	107-110	cyclin D1	Homo sapiens	0-9
19996316-5	2010	Specifically, we identified the extracellular signal-regulated kinase (ERK) signaling pathway as a mediator of signals from FcgammaR activation to cyclin D1 expression, because cyclin D1 expression associated with FcgammaR cross-linking was attenuated by specific inhibitors of the ERK1/2 signaling pathway, PD98059 and U0126 and the spleen tyrosine kinase (Syk) inhibitor, Piceatannol.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	308-315	cyclin D1	Homo sapiens	147-156
19996316-5	2010	Specifically, we identified the extracellular signal-regulated kinase (ERK) signaling pathway as a mediator of signals from FcgammaR activation to cyclin D1 expression, because cyclin D1 expression associated with FcgammaR cross-linking was attenuated by specific inhibitors of the ERK1/2 signaling pathway, PD98059 and U0126 and the spleen tyrosine kinase (Syk) inhibitor, Piceatannol.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	308-315	cyclin D1	Homo sapiens	177-186
19996316-5	2010	Specifically, we identified the extracellular signal-regulated kinase (ERK) signaling pathway as a mediator of signals from FcgammaR activation to cyclin D1 expression, because cyclin D1 expression associated with FcgammaR cross-linking was attenuated by specific inhibitors of the ERK1/2 signaling pathway, PD98059 and U0126 and the spleen tyrosine kinase (Syk) inhibitor, Piceatannol.	U 0126	320-325	cyclin D1	Homo sapiens	147-156
19996316-5	2010	Specifically, we identified the extracellular signal-regulated kinase (ERK) signaling pathway as a mediator of signals from FcgammaR activation to cyclin D1 expression, because cyclin D1 expression associated with FcgammaR cross-linking was attenuated by specific inhibitors of the ERK1/2 signaling pathway, PD98059 and U0126 and the spleen tyrosine kinase (Syk) inhibitor, Piceatannol.	U 0126	320-325	cyclin D1	Homo sapiens	177-186
19996316-5	2010	Specifically, we identified the extracellular signal-regulated kinase (ERK) signaling pathway as a mediator of signals from FcgammaR activation to cyclin D1 expression, because cyclin D1 expression associated with FcgammaR cross-linking was attenuated by specific inhibitors of the ERK1/2 signaling pathway, PD98059 and U0126 and the spleen tyrosine kinase (Syk) inhibitor, Piceatannol.	3,3',4,5'-tetrahydroxystilbene	374-385	cyclin D1	Homo sapiens	147-156
19996316-5	2010	Specifically, we identified the extracellular signal-regulated kinase (ERK) signaling pathway as a mediator of signals from FcgammaR activation to cyclin D1 expression, because cyclin D1 expression associated with FcgammaR cross-linking was attenuated by specific inhibitors of the ERK1/2 signaling pathway, PD98059 and U0126 and the spleen tyrosine kinase (Syk) inhibitor, Piceatannol.	3,3',4,5'-tetrahydroxystilbene	374-385	cyclin D1	Homo sapiens	177-186
20332435-5	2010	However, inclusion of curcumin to continued FOLFOX treatment for another 48 h greatly reduced the survival of these cells, accompanied by a concomitant reduction in activation of EGFR, HER-2, IGF-1R and AKT, as well as expression of COX-2 and cyclin-D1.	Curcumin	22-30	cyclin D1	Homo sapiens	243-252
19966835-10	2010	Aspirin inhibits GSK-3beta activation and suppresses the expression of its downstream gene products (cyclin D1 and Bcl-2), which are implicated in proliferation, survival and chemoresistance of pancreatic cancer.	Aspirin	0-7	cyclin D1	Homo sapiens	101-110
19962318-5	2010	Further characterization of SK2009 indicates that this newly synthesized molecule can suppress TNF-induced IkappaBalpha kinase activation and inhibit the expression of three NF-kappaB-dependent gene products, cyclin D1, Bcl-2, and VEGF, in these cells.	sk2009	28-34	cyclin D1	Homo sapiens	209-218
20809980-11	2010	PGG treatment led to decreased cyclin D1 in both cell lines and over-expressing cyclin D1 attenuated G(1) arrest and hastened S arrest.	beta-penta-O-galloyl-glucose	0-3	cyclin D1	Homo sapiens	31-40
20809980-11	2010	PGG treatment led to decreased cyclin D1 in both cell lines and over-expressing cyclin D1 attenuated G(1) arrest and hastened S arrest.	beta-penta-O-galloyl-glucose	0-3	cyclin D1	Homo sapiens	80-89
20809980-12	2010	In serum-starvation synchronized MCF-7 cells, down-regulation of cyclin D1 was associated with de-phosphorylation of retinoblastoma (Rb) protein by PGG shortly before G(1)-S transition.	beta-penta-O-galloyl-glucose	148-151	cyclin D1	Homo sapiens	65-74
19882219-6	2010	This finding was validated by immunohistochemical staining of Ki67 and Cyclin D1 in Formalin-Fixed Paraffin-Embedded (FFPE) section of the same samples, and in an independent cohort of FFPE matched tumor and metastatic tissue samples.	Formaldehyde	84-92	cyclin D1	Homo sapiens	71-80
20422883-5	2010	RESULTS: 50 microM progesterone increased both the cytotoxic and apoptotic effects of 0.1 microg/ml epirubicin on HepG2 cells at 48 hr culture due to 50 microM progesterone accumulated cells in S phase of the cell cycle and subsequently reduced cyclin D1 expression.	Epirubicin	100-110	cyclin D1	Homo sapiens	245-254
19661225-7	2010	In contrast, rapamycin-induced inhibition of mTOR did not significantly affect cell proliferation because it simultaneously stimulated PI3K/Akt activation and cyclin D1 expression.	Sirolimus	13-22	cyclin D1	Homo sapiens	159-168
19911372-6	2010	In addition, the increased tyrosine phosphorylation level of beta-catenin was associated with the increased nuclear level of beta-catenin and downstream signaling molecules such as c-myc and cyclin D1 that were associated with cell proliferation.	Tyrosine	27-35	cyclin D1	Homo sapiens	191-200
19920184-4	2009	Downstream of Akt, IP6 inhibited the phosphorylation of glycogen synthase kinase-3alpha/beta at Ser(21/9) and consequently reduced cyclin D1 expression.	Phytic Acid	19-22	cyclin D1	Homo sapiens	131-140
19767775-0	2009	Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation.	Lysine	0-6	cyclin D1	Homo sapiens	28-37
19767775-3	2009	We have assessed the role of lysine residues proximal to the cyclin D1 phosphodegron for ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ubiquitin ligase and subsequent proteasome-dependent degradation of cyclin D1.	Lysine	29-35	cyclin D1	Homo sapiens	61-70
19767775-3	2009	We have assessed the role of lysine residues proximal to the cyclin D1 phosphodegron for ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ubiquitin ligase and subsequent proteasome-dependent degradation of cyclin D1.	Lysine	29-35	cyclin D1	Homo sapiens	207-216
19767775-4	2009	The work described herein reveals a requisite role for Lys-269 (K269) for the rapid polyubiquitin-mediated degradation of cyclin D1.	Lysine	55-58	cyclin D1	Homo sapiens	122-131
19767775-5	2009	Mutation of Lys-269, which is proximal to the phosphodegron sequence surrounding Thr-286 in cyclin D1, not only stabilizes cyclin D1 but also triggers cyclin D1 accumulation within the nucleus, thereby promoting cell transformation.	Lysine	12-15	cyclin D1	Homo sapiens	92-101
19767775-5	2009	Mutation of Lys-269, which is proximal to the phosphodegron sequence surrounding Thr-286 in cyclin D1, not only stabilizes cyclin D1 but also triggers cyclin D1 accumulation within the nucleus, thereby promoting cell transformation.	Lysine	12-15	cyclin D1	Homo sapiens	123-132
19767775-5	2009	Mutation of Lys-269, which is proximal to the phosphodegron sequence surrounding Thr-286 in cyclin D1, not only stabilizes cyclin D1 but also triggers cyclin D1 accumulation within the nucleus, thereby promoting cell transformation.	Lysine	12-15	cyclin D1	Homo sapiens	123-132
19767775-5	2009	Mutation of Lys-269, which is proximal to the phosphodegron sequence surrounding Thr-286 in cyclin D1, not only stabilizes cyclin D1 but also triggers cyclin D1 accumulation within the nucleus, thereby promoting cell transformation.	Threonine	81-84	cyclin D1	Homo sapiens	92-101
19767775-5	2009	Mutation of Lys-269, which is proximal to the phosphodegron sequence surrounding Thr-286 in cyclin D1, not only stabilizes cyclin D1 but also triggers cyclin D1 accumulation within the nucleus, thereby promoting cell transformation.	Threonine	81-84	cyclin D1	Homo sapiens	123-132
19767775-5	2009	Mutation of Lys-269, which is proximal to the phosphodegron sequence surrounding Thr-286 in cyclin D1, not only stabilizes cyclin D1 but also triggers cyclin D1 accumulation within the nucleus, thereby promoting cell transformation.	Threonine	81-84	cyclin D1	Homo sapiens	123-132
19767775-7	2009	Strikingly, although mutation of lysine 269 to arginine inhibits cyclin D1 degradation, it does not inhibit cyclin D1 ubiquitylation in vivo, showing that ubiquitylation of a specific lysine can influence substrate targeting to the 26S proteasome.	Lysine	33-39	cyclin D1	Homo sapiens	65-74
19957063-3	2009	We recently found that Rottlerin inhibits the transcription factor nuclear factor kappaB in different cell types, causing downregulation of cyclin D1 and growth arrest.	rottlerin	23-32	cyclin D1	Homo sapiens	140-149
19935879-0	2009	Wogonin induces G1 phase arrest through inhibiting Cdk4 and cyclin D1 concomitant with an elevation in p21Cip1 in human cervical carcinoma HeLa cells.	wogonin	0-7	cyclin D1	Homo sapiens	60-69
19935879-7	2009	Collectively, our data suggested that wogonin induced G1 phase arrest in HeLa cells by modulating several key G1 regulatory proteins, such as Cdk4 and cyclin D1, as well as up-regulation of a p53-mediated p21Cip1 expression.	wogonin	38-45	cyclin D1	Homo sapiens	151-160
19889545-0	2009	Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of cyclin D1-CDK4: synthesis, biological evaluation and structure-activity relationships.	thieno[2,3-d]pyrimidin-4-yl hydrazone	19-56	cyclin D1	Homo sapiens	77-86
19764998-7	2009	Moreover, depletion of endogenous pescadillo resulted in decreased expression of cell cycle protein cyclin D1 and up-regulation of cyclin-dependent kinase inhibitor p27(Kip1), as well as attenuated protein kinase B (Akt)/glycogen synthase kinase 3 beta (GSK-3beta) signaling.	pescadillo	34-44	cyclin D1	Homo sapiens	100-109
20332458-4	2010	Here, we investigated the mechanism of cyclin D1 expression induced by interleukin-6 (IL-6) and whether 3-[3,4-dihydroxy-phenyl]-acrylic acid 2-[3,4-dihydroxy-phenyl]-ethyl ester (CADPE), a derivate of caffeic acid, suppresses cyclin D1 expression.	3-(3,4-dihydroxyphenyl)acrylic acid 2-(3,4-dihydroxyphenyl)ethyl ester	104-178	cyclin D1	Homo sapiens	227-236
20332458-4	2010	Here, we investigated the mechanism of cyclin D1 expression induced by interleukin-6 (IL-6) and whether 3-[3,4-dihydroxy-phenyl]-acrylic acid 2-[3,4-dihydroxy-phenyl]-ethyl ester (CADPE), a derivate of caffeic acid, suppresses cyclin D1 expression.	cadpe	180-185	cyclin D1	Homo sapiens	39-48
20332458-4	2010	Here, we investigated the mechanism of cyclin D1 expression induced by interleukin-6 (IL-6) and whether 3-[3,4-dihydroxy-phenyl]-acrylic acid 2-[3,4-dihydroxy-phenyl]-ethyl ester (CADPE), a derivate of caffeic acid, suppresses cyclin D1 expression.	caffeic acid	202-214	cyclin D1	Homo sapiens	39-48
19845689-6	2010	Furthermore, heparin inhibited cyclin-dependent kinase inhibitor p21(WAF1/CIP1) and p53 tumour suppressor gene and protein expression up to 2-fold or 1.8-fold, respectively, and stimulated cyclin D1 expression up to 1.8-fold, in these cell lines through a p38-mediated mechanism.	Heparin	13-20	cyclin D1	Homo sapiens	189-198
19922488-8	2010	These findings strongly suggest that anti-proliferative effects of gamma-tocotrienol are associated with reduction in cell cycle progression from G(1) to S, as evidenced by increased p27 levels, and a corresponding decrease in cyclin D1, CDK2, CDK4, CDK6 and phosphorylated Rb levels.	plastochromanol 8	67-84	cyclin D1	Homo sapiens	227-236
20028382-5	2010	Treatment with resveratrol led to G(1) phase cell cycle arrest in T24 cells by activation of p21 and downregulation of cyclin D1, cyclin-dependent kinase 4, and phosphorylated Rb.	Resveratrol	15-26	cyclin D1	Homo sapiens	119-128
19763792-9	2010	Finally, blockade of either CaM KK (with STO-609) or ERK (with U0126) activities resulted in the inhibition of carbachol- and estrogen-mediated cyclin D1 expression and MCF-7 cell growth.	U 0126	63-68	cyclin D1	Homo sapiens	144-153
19763792-9	2010	Finally, blockade of either CaM KK (with STO-609) or ERK (with U0126) activities resulted in the inhibition of carbachol- and estrogen-mediated cyclin D1 expression and MCF-7 cell growth.	Carbachol	111-120	cyclin D1	Homo sapiens	144-153
19763792-10	2010	Taken together, our results suggest that carbachol treatment of MCF-7 cells activates CaM KI, ERK, the transcription factor Elk-1, cyclin D1, and cell growth through CaM KK.	Carbachol	41-50	cyclin D1	Homo sapiens	131-140
19917880-9	2010	In vitro assays for CDK4 kinase activity demonstrated that RB1 phosphorylation by the AHR/CDK4/CCND1 complex was reduced in the presence of TCDD.	Polychlorinated Dibenzodioxins	140-144	cyclin D1	Homo sapiens	95-100
19585470-6	2010	When treated with the compound in T47D cells, schizandrin induced the accumulation of a cell population in the G0/G1 phase, which was further demonstrated by the induction of CDK inhibitors p21 and p27 and the inhibition of the expression of cell cycle checkpoint proteins including cyclin D1, cyclin A, CDK2 and CDK4.	schizandrin	46-57	cyclin D1	Homo sapiens	283-292
19737073-9	2010	Negatively regulated expression of CCND1, CCNE2, or NF-kappaB in EGCG-treated cells was restored by removing EGCG, but not CCNA2 and CCNB1.	epigallocatechin gallate	65-69	cyclin D1	Homo sapiens	35-40
19737073-9	2010	Negatively regulated expression of CCND1, CCNE2, or NF-kappaB in EGCG-treated cells was restored by removing EGCG, but not CCNA2 and CCNB1.	epigallocatechin gallate	109-113	cyclin D1	Homo sapiens	35-40
19933579-5	2010	Balloon injury-induced cyclin D1-CDK4 activity requires NFAT activation, and adenovirus-mediated transduction of cyclin D1 was found to be sufficient to overcome the blockade effect of NFATs by VIVIT on balloon injury-induced vascular wall remodeling events, including smooth muscle cell migration from the medial to luminal region, their proliferation in the intimal region, and neointima formation.	NFAT Inhibitor	194-199	cyclin D1	Homo sapiens	23-32
19933579-5	2010	Balloon injury-induced cyclin D1-CDK4 activity requires NFAT activation, and adenovirus-mediated transduction of cyclin D1 was found to be sufficient to overcome the blockade effect of NFATs by VIVIT on balloon injury-induced vascular wall remodeling events, including smooth muscle cell migration from the medial to luminal region, their proliferation in the intimal region, and neointima formation.	NFAT Inhibitor	194-199	cyclin D1	Homo sapiens	113-122
20010939-2	2010	Anti-estrogens, such as tamoxifen, antagonise estrogen-induced ERalpha transactivation of cyclin D1, resulting in reduced CDK4/6 activity, p27(Kip1)-mediated inhibition of CDK2 and growth arrest.	Tamoxifen	24-33	cyclin D1	Homo sapiens	90-99
19682434-9	2010	Curcumin abolished the constitutive activation of NF-kappaB in the tumor tissue; induced apoptosis, and decreased cyclin D1, VEGF, COX-2, c-myc and Bcl-2 expression in the bladder cancer tissue.	Curcumin	0-8	cyclin D1	Homo sapiens	114-123
20067614-12	2010	Cyclopamine reduced the expression of accelerators of the cell cycle including cyclin D1, cyclin E1, SKP2, and pRb.	cyclopamine	0-11	cyclin D1	Homo sapiens	79-88
19909759-9	2010	Furthermore, berberine and the extract inhibited the expression of the proto-oncogene cyclin D1.	Berberine	13-22	cyclin D1	Homo sapiens	86-95
19966541-19	2010	The gap junction inhibitor carbenexolone was shown to increase cell proliferation by increased cyclin D1 expression, MTT assay, and Ki67 expression.	carbenexolone	27-40	cyclin D1	Homo sapiens	95-104
19962966-4	2010	Murrayafoline A repressed the expression of cyclin D1 and c-myc, which is known beta-catenin/T cell factor (TCF)-dependent genes and thus inhibited the proliferation of various colon cancer cells.	murrayafoline	0-13	cyclin D1	Homo sapiens	44-53
20686221-9	2010	Moreover, curcumin induced the expression of cyclin dependent kinase inhibitor genes p21 and p27, while it inhibited the expression of numerous genes, including Bcl-2, cyclin D1, CDK2, CDK4 and CDK6.	Curcumin	10-18	cyclin D1	Homo sapiens	168-177
19624598-8	2009	Fibronectin antagonized MMC-induced G0/G1-phase arrest by inactivating GSK-3beta to stabilize cyclin D1 expression in T24 cells.	Mitomycin	24-27	cyclin D1	Homo sapiens	94-103
19843642-8	2009	The anti-proliferation activity of Cucurbitacin I was accompanied by downregulation of phospho-STAT3 and STAT3 target gene expression (e.g. cyclin D1 and Mcl-1).	cucurbitacin I	35-49	cyclin D1	Homo sapiens	140-149
20359085-2	2009	METHOD: Ninety-two cases of paraffin section with immunoperoxidase (SP) staining method was used to detect the distribution of Pin1 and CyclinD1 in 10 cases of laryngeal normal epithelial tissue, 39 cases of laryngeal papilloma, 27 cases of laryngeal papilloma with middle, severe atypical hyperplasia and 16 cases of laryngeal carcinoma.	Paraffin	28-36	cyclin D1	Homo sapiens	136-144
19504174-6	2009	Signaling analysis data further demonstrated that myricetin inhibited Akt-mediated activator protein-1 (AP-1) transactivation, cyclin D1 expression and cell transformation.	myricetin	50-59	cyclin D1	Homo sapiens	127-136
19801633-0	2009	Cyclin D1 induction by benzo[a]pyrene-7,8-diol-9,10-epoxide via the phosphatidylinositol 3-kinase/Akt/MAPK- and p70s6k-dependent pathway promotes cell transformation and tumorigenesis.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	23-59	cyclin D1	Homo sapiens	0-9
19487074-2	2009	The treatment of cells with piceatannol for 24h resulted in an increase in the percentage of cells in G1 phase and dose-dependent decreases in [(3)H]thymidine incorporation, as well as in protein levels of cyclin A, cyclin D1, and cyclin-dependent kinase (CDK)2 and CDK4.	3,3',4,5'-tetrahydroxystilbene	28-39	cyclin D1	Homo sapiens	216-225
19801633-5	2009	Furthermore, we found that overexpression of the dominant negative mutant of p85 (regulatory subunit of phosphatidylinositol 3-kinase) or Akt dramatically suppressed B[a]PDE-induced JNK and Erk activation as well as cyclin D1 expression, suggesting that cyclin D1 induction by B[a]PDE is via the phosphatidylinositol 3-kinase/Akt/MAPK-dependent pathway.	Phosphatidylinositols	104-124	cyclin D1	Homo sapiens	216-225
19801633-6	2009	In addition, we clarified that p70(s6k) is also involved in B[a]PDE-induced cyclin D1 expression because rampamycin pretreatment dramatically reduced cyclin D1 induction by B[a]PDE.	rampamycin	105-115	cyclin D1	Homo sapiens	76-85
19801633-6	2009	In addition, we clarified that p70(s6k) is also involved in B[a]PDE-induced cyclin D1 expression because rampamycin pretreatment dramatically reduced cyclin D1 induction by B[a]PDE.	rampamycin	105-115	cyclin D1	Homo sapiens	150-159
19903334-0	2009	The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation.	Caffeine	38-46	cyclin D1	Homo sapiens	56-65
19903334-7	2009	Exposure of human cancer cell lines to caffeine and CGK733 was associated with a rapid decline in cyclin D1 protein levels and a reduction in the levels of both phosphorylated and total retinoblastoma protein (RB).	Caffeine	39-47	cyclin D1	Homo sapiens	98-107
19903334-9	2009	The differential effects of caffeine/CGK733 and KU55933 on cyclin D1 protein levels suggest that these agents will exhibit dissimilar molecular pharmacological profiles.	Caffeine	28-36	cyclin D1	Homo sapiens	59-68
19903334-9	2009	The differential effects of caffeine/CGK733 and KU55933 on cyclin D1 protein levels suggest that these agents will exhibit dissimilar molecular pharmacological profiles.	2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one	48-55	cyclin D1	Homo sapiens	59-68
19878865-2	2009	reports that the iron-dependent 2-oxoglutarate dioxygenase or prolyl hydroxylase EglN2 induces Cyclin D1 levels, egging on breast tumorigenesis.	Iron	17-21	cyclin D1	Homo sapiens	95-104
19444595-0	2009	Modulation of p53, c-fos, RARE, cyclin A, and cyclin D1 expression in human leukemia (HL-60) cells exposed to arsenic trioxide.	Arsenic Trioxide	110-126	cyclin D1	Homo sapiens	46-55
19823037-7	2009	The results from semi-quantitative and real-time RT-PCR indicated that DATS-enhanced the expression levels of FAS and cyclin D1, but in contrast, downregulated the expression levels of Akt and Bcl-2.	diallyl trisulfide	71-75	cyclin D1	Homo sapiens	118-127
19623659-0	2009	Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model.	Curcumin	0-8	cyclin D1	Homo sapiens	77-86
19623659-0	2009	Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model.	Capecitabine	47-59	cyclin D1	Homo sapiens	77-86
19892663-10	2009	Stromal VEGF and cyclin D1 expression were downregulated in clinically responsive GTE patients and upregulated in nonresponsive patients at 12 weeks (versus at baseline).	gte	82-85	cyclin D1	Homo sapiens	17-26
19787257-8	2009	Treatment with lovastatin or celecoxib decreased the levels of cyclin D1, CDK2, pRb and E2F1, while the combination treatment showed more pronounced suppression.	Lovastatin	15-25	cyclin D1	Homo sapiens	63-72
19787257-8	2009	Treatment with lovastatin or celecoxib decreased the levels of cyclin D1, CDK2, pRb and E2F1, while the combination treatment showed more pronounced suppression.	Celecoxib	29-38	cyclin D1	Homo sapiens	63-72
19362368-6	2009	Moreover, H3K9 acetylation at c-myc and CCND1 promoters was increased in individual MM patients after melphalan treatment.	Melphalan	102-111	cyclin D1	Homo sapiens	40-45
21160963-4	2009	In both the BilIN and IPNB series, the expression of p21, p53, and cyclin D1 was upregulated with histological progression.	Bile Pigments	12-17	cyclin D1	Homo sapiens	67-76
19921577-7	2009	Cyclin D1 positive cells showed more sensitive to 5-FU and HCPT than cyclin D1 negative cells.	Fluorouracil	50-54	cyclin D1	Homo sapiens	0-9
19921577-7	2009	Cyclin D1 positive cells showed more sensitive to 5-FU and HCPT than cyclin D1 negative cells.	homocamptothecin	59-63	cyclin D1	Homo sapiens	0-9
21160963-4	2009	In both the BilIN and IPNB series, the expression of p21, p53, and cyclin D1 was upregulated with histological progression.	ipnb	22-26	cyclin D1	Homo sapiens	67-76
19560490-3	2009	Flavopiridol reduced the expression of a cell cycle protein (cyclin D1) in microglia surrounding probes at the 3-day time point.	alvocidib	0-12	cyclin D1	Homo sapiens	61-70
19573523-6	2009	Curcumin was found to effectively inhibit the expression of several Wnt/beta-catenin pathway components-disheveled, beta-catenin, cyclin D1 and slug in both MCF-7 and MDA-MB-231.	Curcumin	0-8	cyclin D1	Homo sapiens	130-139
19573523-8	2009	Further, the protein levels of the positively regulated beta-catenin targets-cyclin D1 and slug, were downregulated by curcumin treatment.	Curcumin	119-127	cyclin D1	Homo sapiens	77-86
19735878-9	2009	Curcumin also suppressed NF-kappaB-regulated gene products (Bcl-2, Bcl-x(L), inhibitor of apoptosis protein-2, cyclooxygenase-2, and cyclin D1).	Curcumin	0-8	cyclin D1	Homo sapiens	133-142
19669889-4	2009	Our results showed that EGCG treatment caused cell proliferation inhibition during I/R injury, and this effect was associated with increased p27 and p21 levels and reduced cyclin D1 level.	epigallocatechin gallate	24-28	cyclin D1	Homo sapiens	172-181
19823825-5	2009	Proliferating haemangiomas with the amplified cyclin D1 gene required more frequent flashlamp pulsed dye laser treatment sessions at the maximum dosimetry and more frequent intralesional steroid injections at the maximum dose/injection but treatment outcomes were limited.	Steroids	187-194	cyclin D1	Homo sapiens	46-55
19589865-0	2009	Increased mitogen-activated protein kinase kinase/extracellularly regulated kinase activity in human endometrial stromal fibroblasts of women with endometriosis reduces 3",5"-cyclic adenosine 5"-monophosphate inhibition of cyclin D1.	3",5"-cyclic adenosine 5"-monophosphate	169-208	cyclin D1	Homo sapiens	223-232
19589865-4	2009	Here, we demonstrate that 8-Br-cAMP inhibits bromodeoxyuridine incorporation and cyclin D1 (CCND1) expression in cultured human endometrial stromal fibroblasts (hESF) from women without but not with endometriosis.	8-Bromo Cyclic Adenosine Monophosphate	26-35	cyclin D1	Homo sapiens	81-90
19589865-4	2009	Here, we demonstrate that 8-Br-cAMP inhibits bromodeoxyuridine incorporation and cyclin D1 (CCND1) expression in cultured human endometrial stromal fibroblasts (hESF) from women without but not with endometriosis.	8-Bromo Cyclic Adenosine Monophosphate	26-35	cyclin D1	Homo sapiens	92-97
19589865-6	2009	The MAPK kinase-1/2 inhibitor, U0126, fully restored cAMP down-regulation of CCND1, but not cAMP up-regulation of IGFBP1, in hESF of women with vs. without endometriosis.	U 0126	31-36	cyclin D1	Homo sapiens	77-82
19589865-6	2009	The MAPK kinase-1/2 inhibitor, U0126, fully restored cAMP down-regulation of CCND1, but not cAMP up-regulation of IGFBP1, in hESF of women with vs. without endometriosis.	Cyclic AMP	53-57	cyclin D1	Homo sapiens	77-82
19786833-4	2009	By using the Dnmt3a/c-myc interaction as an example, we here showed that this interaction promotes the site-specific methylation of CG dinucleotides localized in c-myc boxes of promoter regions of CDKN2a, CCND1 and TIMP2 genes.	cytidylyl-3'-5'-guanosine	132-148	cyclin D1	Homo sapiens	205-210
19724890-3	2009	Schisandrin C induced G1 arrest was correlated with down-regulation of cyclin D1, cyclin E, cyclin-dependent kinase (Cdk) 4 and E2Fs expression, inhibition of phosphorylation of retinoblastoma protein (pRB), and up-regulation of the Cdk inhibitor p21(WAF1/CIP1).	schizandrin C	0-13	cyclin D1	Homo sapiens	71-80
19724892-6	2009	In HL-60 cells 50% proliferation inhibition was achieved by 1.7 microg dichloromethane extract/ml medium and correlated with the activation of Chk2, down-regulation of Cdc25A, suppression of cyclin D1 level, and transient induction of p21.	Methylene Chloride	71-86	cyclin D1	Homo sapiens	191-200
19443725-5	2009	However, preinhibition of glycogen synthase kinase (GSK)-3 activation with 20 microM SB415286 prolonged and augmented this Erk1/2 response to EGF but decreased cyclin D1 expression, whereas p27Kip1 levels rose.	3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione	85-93	cyclin D1	Homo sapiens	160-169
19710155-9	2009	Trig treatment also induced activation of estrogen response element reporter assays in MCF-7 cells and increased expression of ER target genes (pS2, progesterone receptor, and cyclin D1) similar to E(2).	trigonelline	0-4	cyclin D1	Homo sapiens	176-185
19415719-1	2009	Alternative splicing in the cyclin D1 gene produces cyclin D1b variant which lacks a C-terminal region containing the threonine-286 (T286) phosphorylation site required for nuclear export.	Threonine	118-127	cyclin D1	Homo sapiens	28-37
19698731-3	2009	The levels of phosphorylated-mTOR (p-mTOR), cyclin D1 and p21(WAF1/CIP1/SDI1) expression were significantly higher in WI-38 cells treated with l-leucine (an activator of mTOR) (P &lt; 0.05).	Leucine	143-152	cyclin D1	Homo sapiens	44-53
19698731-5	2009	The levels of p-mTOR, cyclin D1, and p21(WAF1/CIP1/SDI1) as well as the aging-related phenotypes were all reduced in cells treated with rapamycin (an inhibitor of mTOR) than in control cells (P &lt; 0.05).	Sirolimus	136-145	cyclin D1	Homo sapiens	22-31
19415719-1	2009	Alternative splicing in the cyclin D1 gene produces cyclin D1b variant which lacks a C-terminal region containing the threonine-286 (T286) phosphorylation site required for nuclear export.	C.I. Basic Blue 54	133-137	cyclin D1	Homo sapiens	28-37
19595669-5	2009	Moreover, the expression of STAT3 target genes such as Cyclin D1, XIAP, and Bcl-2 that are essential for cell growth and survival was apparently attenuated after aspirin treatment.	Aspirin	162-169	cyclin D1	Homo sapiens	55-64
19789217-5	2009	Zoledronic acid caused a small reduction in tumor volume, reduced tumor cell proliferation, and decreased expression of cyclins D1 and D3, compared with tumors from animals treated with saline or doxorubicin.	Zoledronic Acid	0-15	cyclin D1	Homo sapiens	120-137
19607803-4	2009	Moreover, isoreserpine repressed the expression of beta-catenin/T-cell factor (TCF)-dependent genes, such as cyclin D1 and c-myc, resulting in the suppression of HCT116 cell proliferation.	Isoreserpine	10-22	cyclin D1	Homo sapiens	109-118
19427301-4	2009	In this study we provide evidence that dichlorophenyl form of thiadiazolidine (designated as P(3)-25) is a potential inducer of cell death by arresting cell cycle at G1 phase and decreases the amounts of cyclin D1 and cyclin E without interfering p16 and p27.	dichlorophenyl	39-53	cyclin D1	Homo sapiens	204-213
19346066-4	2009	Pentobarbital also leads to a G1 phase cell cycle arrest accompanied by suppressed G1 cell cycle regulatory proteins Cyclin D1, Cyclin D3, CDK2 and phosphorylated Rb.	Pentobarbital	0-13	cyclin D1	Homo sapiens	117-126
19592491-4	2009	Here we show that SRPK2, a protein kinase specific for the serine/arginine (SR) family of splicing factors, triggers cell cycle progression in neurons and induces apoptosis through regulation of nuclear cyclin D1.	Serine	59-65	cyclin D1	Homo sapiens	203-212
19592491-4	2009	Here we show that SRPK2, a protein kinase specific for the serine/arginine (SR) family of splicing factors, triggers cell cycle progression in neurons and induces apoptosis through regulation of nuclear cyclin D1.	Arginine	66-74	cyclin D1	Homo sapiens	203-212
19592491-5	2009	Akt phosphorylates SRPK2 on Thr-492 and promotes its nuclear translocation leading to cyclin D1 up-regulation, cell cycle reentry, and neuronal apoptosis.	Threonine	28-31	cyclin D1	Homo sapiens	86-95
19427301-4	2009	In this study we provide evidence that dichlorophenyl form of thiadiazolidine (designated as P(3)-25) is a potential inducer of cell death by arresting cell cycle at G1 phase and decreases the amounts of cyclin D1 and cyclin E without interfering p16 and p27.	thiadiazolidine	62-77	cyclin D1	Homo sapiens	204-213
19467018-1	2009	Demonstration of cyclin D1 expression by immunohistochemistry in a CD5-positive small B-cell proliferation is extremely helpful in the diagnosis of mantle cell lymphoma in tissue samples, including bone marrow trephine biopsies (BMTB) and in differentiating them from chronic lymphocytic leukaemia (CLL).	trephine	210-218	cyclin D1	Homo sapiens	17-26
19633425-7	2009	Sorafenib inhibited the phosphorylation of MEK and ERK, downregulated cyclin D1 and Rb levels, caused G(1) arrest and S phase decrease, and induced apoptosis as confirmed by flow cytometry and the TUNEL assay.	Sorafenib	0-9	cyclin D1	Homo sapiens	70-79
19704260-0	2009	Improved diagnostic segregation of mantle cell lymphoma by determination of cyclin D1/D3 expression ratio in formalin-fixed tissue.	Formaldehyde	109-117	cyclin D1	Homo sapiens	76-85
19704260-9	2009	In conclusion, the cyclin D1/D3 expression ratio gave an improved segregation of MCLs from CLLs, FLs, MALTs, and reactive lymph nodes, as compared with determination of cyclin D1 alone in formalin-fixed, paraffin-embedded tissue.	Formaldehyde	188-196	cyclin D1	Homo sapiens	19-28
19387464-5	2009	Treatment of the cell lines with 5-aza-2"-deoxycytidine induced reexpression of methylated Wnt antagonists and inactivation of the Wnt pathway by downregulating the Wnt pathway genes cyclin D1, TCF1 and LEF1 and reducing nuclear localization of beta-catenin.	Decitabine	33-55	cyclin D1	Homo sapiens	183-192
19552924-8	2009	MG132 treatment also caused increased p21(Waf1/Cip1) and decreased cyclin D1 expression, suggesting that growth suppression may occur through cell cycle arrest.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	0-5	cyclin D1	Homo sapiens	67-76
19372209-3	2009	Based on our finding that thiazolidinediones suppress beta-catenin and cyclin D1 by up-regulating the E3 ligase SCF(beta-TrCP), we hypothesized that beta-transducin repeat-containing protein (beta-TrCP) targets Sp1 for proteasomal degradation in response to glucose starvation or OSU-CG12.	Thiazolidinediones	26-44	cyclin D1	Homo sapiens	71-80
19477949-0	2009	Resistance to antiestrogen arzoxifene is mediated by overexpression of cyclin D1.	LY 353381	27-37	cyclin D1	Homo sapiens	71-80
19477949-4	2009	In this study, we show that overexpression of a regular component of the ERalpha transcription factor complex, cyclin D1, which occurs in approximately 40% of breast cancer patients, renders cells resistant to the new promising antiestrogen, arzoxifene.	LY 353381	242-252	cyclin D1	Homo sapiens	111-120
19477949-5	2009	Overexpression of cyclin D1 alters the conformation of ERalpha in the presence of arzoxifene.	LY 353381	82-92	cyclin D1	Homo sapiens	18-27
19477949-8	2009	This can be explained by a stabilization of the ERalpha/steroid receptor coactivator-1 complex in the presence of arzoxifene, only when cyclin D1 is overexpressed.	LY 353381	114-124	cyclin D1	Homo sapiens	136-145
19542220-7	2009	Treatment of p53 mutant colon cancer cells with 5-FU led to an elongated G1 in a Mirk-dependent manner, as G1 was shortened by ectopic overexpression of cyclin D1 mutated at the Mirk phosphorylation site (T288A), but not by wild-type cyclin D1.	Fluorouracil	48-52	cyclin D1	Homo sapiens	153-162
19542220-7	2009	Treatment of p53 mutant colon cancer cells with 5-FU led to an elongated G1 in a Mirk-dependent manner, as G1 was shortened by ectopic overexpression of cyclin D1 mutated at the Mirk phosphorylation site (T288A), but not by wild-type cyclin D1.	Fluorouracil	48-52	cyclin D1	Homo sapiens	234-243
19632122-0	2009	Fascaplysin-inspired diindolyls as selective inhibitors of CDK4/cyclin D1.	diindolyls	21-31	cyclin D1	Homo sapiens	64-73
19632122-1	2009	We present the design, synthesis and biological activity of a new series of substituted 3-(2-(1H-indol-1-yl)ethyl)-1H-indoles and 1,2-di(1H-indol-1-yl)alkanes as selective inhibitors of CDK4/cyclin D1.	3-(2-(1h-indol-1-yl)ethyl)-1h-indoles	88-125	cyclin D1	Homo sapiens	191-200
19632122-1	2009	We present the design, synthesis and biological activity of a new series of substituted 3-(2-(1H-indol-1-yl)ethyl)-1H-indoles and 1,2-di(1H-indol-1-yl)alkanes as selective inhibitors of CDK4/cyclin D1.	1,2-di(1h-indol-1-yl)alkanes	130-158	cyclin D1	Homo sapiens	191-200
19384950-6	2009	Additionally, we found that diosgenin caused G1 cell cycle arrest by downregulating cyclin D1, cdk-2 and cdk-4 expression in both ER(+) and ER(-) BCa cells resulting in the inhibition of cell proliferation and induction of apoptosis.	Diosgenin	28-37	cyclin D1	Homo sapiens	84-93
19491660-3	2009	A marked reduction in cyclin D1 levels and an increase in p27 levels were observed when 100 micromol/l of isoquercitrin was added to Gbm cells.	isoquercitrin	106-119	cyclin D1	Homo sapiens	22-31
19403565-6	2009	Only lithium treatment produced clear nuclear localization of cyclin D1 consistent with the proliferative response observed.	Lithium	5-12	cyclin D1	Homo sapiens	62-71
19575044-0	2009	Oligomycin induced the proteasomal degradation of cyclin D1 protein.	Oligomycins	0-10	cyclin D1	Homo sapiens	50-59
19575044-1	2009	We searched for compounds that affect the cyclin D1/retinoblastoma protein pathway from the in-house natural product library using a recombinant adenovirus with the Cre/loxP-regulated cyclin D1 overexpression system, and we found that oligomycin inhibited cell growth more effectively in cyclin D1-overexpressing SW480 cells than in control SW480 cells.	Oligomycins	235-245	cyclin D1	Homo sapiens	42-51
19575044-2	2009	We also found that oligomycin reduced the expression levels of cyclin D1 protein and that this reduction is, at least in part, mediated by Thr-286 phosphorylation-dependent proteasomal degradation.	Oligomycins	19-29	cyclin D1	Homo sapiens	63-72
19575044-2	2009	We also found that oligomycin reduced the expression levels of cyclin D1 protein and that this reduction is, at least in part, mediated by Thr-286 phosphorylation-dependent proteasomal degradation.	Threonine	139-142	cyclin D1	Homo sapiens	63-72
19125423-2	2009	CDODA-Me also induced p21 and p27 protein expression and downregulates cyclin D1; however, these responses were receptor-independent.	methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate	0-8	cyclin D1	Homo sapiens	71-80
19411282-6	2009	As an example, translation efficiency mediated by heparin-binding epidermal growth factor 3-untranslated region was increased 3-fold in liver cancer cells compared with normal hepatocytes, whereas stability of an mRNA containing a portion of Cyclin D1 3-untranslated region was increased more than 2-fold in HepG2 cells compared with normal hepatocytes.	Heparin	50-57	cyclin D1	Homo sapiens	242-251
19640308-9	2009	Auraptene (10 microM) reduced Insulin like Growth Factor-1 (IGF-1, 10 ng/mL)-induced cyclin D1 expression by 40% in MCF-7 cells.	aurapten	0-9	cyclin D1	Homo sapiens	85-94
19584281-7	2009	In particular, ERbeta was able to translate the effects of SDF-1 on its own expression, as well as enhance activator protein 1 (AP-1) containing genes cyclin D1 and c-Myc in the presence of tamoxifen.	Tamoxifen	190-199	cyclin D1	Homo sapiens	151-160
19956448-8	2009	Treatment with curcumin led to a dose-dependent decrease in the expression of NICD associated with the induction of cleaved poly ADP-ribose polymerase (PARP), the degradation of cyclin D1 and increase in cyclin-dependent kinase p21.	Curcumin	15-23	cyclin D1	Homo sapiens	178-187
19440035-8	2009	Compared to treatment with either agent alone, co-treatment with DMAG and vorinostat markedly attenuated the levels of cyclin D1 and CDK4, as well as of c-Myc, c-RAF and AKT.	17-(dimethylaminoethylamino)-17-demethoxygeldanamycin	65-69	cyclin D1	Homo sapiens	119-128
19440035-8	2009	Compared to treatment with either agent alone, co-treatment with DMAG and vorinostat markedly attenuated the levels of cyclin D1 and CDK4, as well as of c-Myc, c-RAF and AKT.	Vorinostat	74-84	cyclin D1	Homo sapiens	119-128
19440933-0	2009	Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway.	Quercetin	0-9	cyclin D1	Homo sapiens	84-93
19440933-5	2009	Effects of quercetin on mRNA expression of cyclin D(1) and survivin were detected by semiquantitative RT-PCR.	Quercetin	11-20	cyclin D1	Homo sapiens	43-54
19440933-15	2009	Cyclin D(1) and the survivin gene were downregulated markedly by quercetin in a dose-dependent manner at both the transcription and protein expression levels.	Quercetin	65-74	cyclin D1	Homo sapiens	0-11
19440933-16	2009	CONCLUSION: The results indicate that the molecular mechanism underlying the antitumor effect of quercetin in SW480 colon cancer cells is related to the inhibition of expression of cyclin D(1) and survivin as well as the Wnt/beta-catenin signaling pathway.	Quercetin	97-106	cyclin D1	Homo sapiens	181-192
19448398-0	2009	Curcumin suppresses proliferation and invasion in human gastric cancer cells by downregulation of PAK1 activity and cyclin D1 expression.	Curcumin	0-8	cyclin D1	Homo sapiens	116-125
19448398-6	2009	Curcumin also downregulated the mRNA and the protein expression of cyclin D1 and suppressed transition of the cells from G(1) to S phase.	Curcumin	0-8	cyclin D1	Homo sapiens	67-76
19549798-6	2009	Pterostilbene reduced cell proliferation, down-regulated the expression of c-Myc and cyclin D1, and increased the level of cleaved poly(ADP-ribose) polymerase.	pterostilbene	0-13	cyclin D1	Homo sapiens	85-94
19440038-7	2009	At the molecular level, metformin increases P-AMPK, reduces P-EGFR, EGFR, P-MAPK, P-Src, cyclin D1 and cyclin E (but not cyclin A or B, p27 or p21), and induces PARP cleavage in a dose- and time-dependent manner.	Metformin	24-33	cyclin D1	Homo sapiens	89-98
19685549-0	2009	Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1/2 and cyclin D1.	3,4-dihydroxyphenylethanol	0-14	cyclin D1	Homo sapiens	111-120
21160963-10	2009	Increased expression of cyclin D1 and c-myc was more frequent in the IPNB lineage than BilIN lineage, possibly related to the Wnt signaling pathway associated with the nuclear accumulation of beta-catenin.	ipnb	69-73	cyclin D1	Homo sapiens	24-33
21160963-10	2009	Increased expression of cyclin D1 and c-myc was more frequent in the IPNB lineage than BilIN lineage, possibly related to the Wnt signaling pathway associated with the nuclear accumulation of beta-catenin.	Bile Pigments	87-92	cyclin D1	Homo sapiens	24-33
19519318-0	2009	PI3K/Akt/JNK/c-Jun signaling pathway is a mediator for arsenite-induced cyclin D1 expression and cell growth in human bronchial epithelial cells.	arsenite	55-63	cyclin D1	Homo sapiens	72-81
19222789-5	2009	Furthermore, metalloproteinase (MP) inhibitor GM6001 blocked UVB-induced ERK and AKT activation, cell cycle progression, and decreased the EGFR phosphorylation, demonstrating that MPs mediate the EGFR/ERK/AKT/cyclin D1 pathways and cell cycle progression induced by UVB radiation.	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	46-52	cyclin D1	Homo sapiens	209-218
19412162-7	2009	Cyclin D1 degradation results from a direct interaction with FBXO31 and is dependent on the F-box motif of FBXO31 and phosphorylation of cyclin D1 at Thr 286, which is known to be required for cyclin D1 proteolysis.	Threonine	150-153	cyclin D1	Homo sapiens	0-9
19412162-7	2009	Cyclin D1 degradation results from a direct interaction with FBXO31 and is dependent on the F-box motif of FBXO31 and phosphorylation of cyclin D1 at Thr 286, which is known to be required for cyclin D1 proteolysis.	Threonine	150-153	cyclin D1	Homo sapiens	137-146
19412162-7	2009	Cyclin D1 degradation results from a direct interaction with FBXO31 and is dependent on the F-box motif of FBXO31 and phosphorylation of cyclin D1 at Thr 286, which is known to be required for cyclin D1 proteolysis.	Threonine	150-153	cyclin D1	Homo sapiens	193-202
19366876-8	2009	PD-098059 blocked Rb protein phorsphorylation and the increase in cyclin D(1) and E but not the decrease in p15(INK4B) and p16(INK4A) induced by GDF-9.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-9	cyclin D1	Homo sapiens	66-77
19506034-3	2009	In regulating cyclin D1 expression, the internalized CD44 forms a complex with STAT3 and p300 (acetyltransferase), eliciting STAT3 acetylation at lysine 685 and dimer formation in a cytokine- and growth factor-independent manner.	Lysine	146-152	cyclin D1	Homo sapiens	14-23
19505905-4	2009	Moreover, the induction of cyclin D1 and cyclin E by nickel was shown for the first time in human pulmonary cells, which may be involved in nickel-triggered G(1)/S transition and cell transformation.	Nickel	53-59	cyclin D1	Homo sapiens	27-36
19505905-4	2009	Moreover, the induction of cyclin D1 and cyclin E by nickel was shown for the first time in human pulmonary cells, which may be involved in nickel-triggered G(1)/S transition and cell transformation.	Nickel	140-146	cyclin D1	Homo sapiens	27-36
19505905-8	2009	More importantly, our results verified that overexpressed cyclin B1, veiling the effect of cyclin D1 or cyclin E, mediated nickel-caused M-phase blockage and cell growth inhibition, which may render pulmonary cells more sensitive to DNA damage and facilitates cancer initiation.	Nickel	123-129	cyclin D1	Homo sapiens	91-100
19519318-3	2009	In this study, we demonstrated that arsenite upregulates cyclin D1 expression/activity to promote the growth of human bronchial epithelial Beas-2B cells.	arsenite	36-44	cyclin D1	Homo sapiens	57-66
19519318-5	2009	The inhibition of JNKs or c-Jun by chemical or genetic inhibitors blocks the cyclin D1 induction mediated by arsenite.	arsenite	109-117	cyclin D1	Homo sapiens	77-86
19550397-6	2009	Both doxorubicin- and cisplatin-resistant cells are characterized by the changes in the expression of several cell cycle regulators -- Ki-67, cyclin D1, pRb and p21).	Doxorubicin	5-16	cyclin D1	Homo sapiens	142-151
19492998-3	2009	At the molecular level, Rottlerin hampered the NFkB activation process, causing loss of cyclin D1 and promoting, in a PKCdelta-dependent pathway, ERK activation, which, in turn induced the cell cycle inhibitor p21 Cip1/Kip1.	rottlerin	24-33	cyclin D1	Homo sapiens	88-97
19359655-10	2009	These findings demonstrate that combination low dose statin and gamma-tocotrienol treatment induced mammary tumor cell cycle arrest at G1, resulting from an increase in p27 expression, and a corresponding decrease in cyclin D1, CDK2, and hypophosphorylation of Rb protein.	plastochromanol 8	64-81	cyclin D1	Homo sapiens	217-226
19550397-6	2009	Both doxorubicin- and cisplatin-resistant cells are characterized by the changes in the expression of several cell cycle regulators -- Ki-67, cyclin D1, pRb and p21).	Cisplatin	22-31	cyclin D1	Homo sapiens	142-151
19189297-5	2009	The antitumor activity of CDDO-Me was associated with the inhibition of p-Akt, mammalian target of rapamycin (mTOR), and nuclear factor kappa B (NF-kappaB) signaling proteins and their downstream targets such as p-Bad and p-Foxo3a (Akt); p-S6K1, p-eIF-4E and p-4E-BP1 (mTOR); and COX-2, VEGF and cyclin D1(NF-kappaB).	bardoxolone methyl	26-33	cyclin D1	Homo sapiens	296-305
18761103-6	2009	As many TFs regulate gene expression as a dimer and bind to DNA repeats, we investigated the promotor region of CCND1 and detected a direct repeat sequence in the Atox1 binding site (tentatively referred to as CABE, copper-responsive Atox1 binding element).	Copper	216-222	cyclin D1	Homo sapiens	112-117
19509268-4	2009	Moreover, polysome profile analysis of silibinin-treated cells shows a decrease in polysome content and translation of cyclin D1 mRNA.	Silybin	39-48	cyclin D1	Homo sapiens	119-128
18941930-8	2009	The expression of ki-67 and cyclinD1 were significantly different between UDH and DCIS (P &lt; 0.05) , and a positive correlation was found between expression of Ki-67 and morphological classification of pre-cancerous lesions (r = 0.3522, P &lt; 0.05) as well as cyclinD1 (r = 0.3901, P &lt; 0.05).	6-AMINOHEXYL-URIDINE-C1,5'-DIPHOSPHATE	74-77	cyclin D1	Homo sapiens	28-36
19307757-0	2009	Tunicamycin enhances TRAIL-induced apoptosis by inhibition of cyclin D1 and the subsequent downregulation of survivin.	Tunicamycin	0-11	cyclin D1	Homo sapiens	62-71
19168569-7	2009	Downstream of EGFR, arsenic exposure increased pERK and cyclin D1 levels.	Arsenic	20-27	cyclin D1	Homo sapiens	56-65
19307757-5	2009	Tunicamycin also repressed expression of cyclin D1, a cell cycle regulator commonly overexpressed in thyroid carcinoma.	Tunicamycin	0-11	cyclin D1	Homo sapiens	41-50
19307757-6	2009	Furthermore, silencing cyclin D1 by RNA interference reduced survivin expression and sensitized thyroid cancer cells to TRAIL; in contrast, forced expression of cyclin D1 attenuated tunicamycin-potentiated TRAIL-induced apoptosis via over-riding downregulation of survivin.	Tunicamycin	182-193	cyclin D1	Homo sapiens	161-170
19307757-7	2009	Collectively, our results demonstrated that tunicamycin promoted TRAIL-induced apoptosis, at least in part, by inhibiting the expression of cyclin D1 and subsequent survivin.	Tunicamycin	44-55	cyclin D1	Homo sapiens	140-149
19426693-7	2009	Moreover, knockdown of STAT5a was associated with a concurrent silencing of morphine-induced expression of cyclin D1, demonstrating involvement of STAT5a in morphine-triggered signaling in the regulation of cyclin D1 expression.	Morphine	76-84	cyclin D1	Homo sapiens	207-216
19254730-7	2009	Mevalonic acid prevented fluvastatin inhibition of IGF-1-induced MEK1/2 and ERK1/2 phosphorylation, cyclin D1 expression, and MC proliferation.	Mevalonic Acid	0-14	cyclin D1	Homo sapiens	100-109
19254730-7	2009	Mevalonic acid prevented fluvastatin inhibition of IGF-1-induced MEK1/2 and ERK1/2 phosphorylation, cyclin D1 expression, and MC proliferation.	Fluvastatin	25-36	cyclin D1	Homo sapiens	100-109
19135778-5	2009	The honokiol-induced cell cycle arrest was well correlated with the suppressive expression of CDK4, cyclin D1, CDK2, cyclin E, c-Myc, and phosphorylated retinoblastoma protein (pRb) at Ser780.	honokiol	4-12	cyclin D1	Homo sapiens	100-109
19143028-9	2009	Treatment of Prostaspheres from CD133(hi) SPs in vitro with c-myc or cyclin D1 anti-sense oligonucleotides totally blocked colony forming ability and growth.	Oligonucleotides	90-106	cyclin D1	Homo sapiens	69-78
19426693-0	2009	Involvement of STAT5a signaling in morphine-induced up-regulation of the cyclin D1.	Morphine	35-43	cyclin D1	Homo sapiens	73-82
19289106-5	2009	Suppression of macroautophagy by bafilomycin A(1) induced G(0)/G(1) cell cycle arrest and apoptosis which were accompanied by the down-regulation of cyclin D(1) and cyclin E, the up-regulation of p21(Cip1) as well as cleavages of caspases-3, -7, -8, and -9 and PARP.	bafilomycin A	33-46	cyclin D1	Homo sapiens	149-160
19426693-3	2009	Using confocal microscopy and Western blotting this study showed that morphine treatment was able to activate cytoplasmic STAT5a in CEM x174 cells, which then translocated into the nucleus and bound to elements of the cyclin D1 promoter.	Morphine	70-78	cyclin D1	Homo sapiens	218-227
19426693-7	2009	Moreover, knockdown of STAT5a was associated with a concurrent silencing of morphine-induced expression of cyclin D1, demonstrating involvement of STAT5a in morphine-triggered signaling in the regulation of cyclin D1 expression.	Morphine	76-84	cyclin D1	Homo sapiens	107-116
19426693-7	2009	Moreover, knockdown of STAT5a was associated with a concurrent silencing of morphine-induced expression of cyclin D1, demonstrating involvement of STAT5a in morphine-triggered signaling in the regulation of cyclin D1 expression.	Morphine	157-165	cyclin D1	Homo sapiens	107-116
19426693-7	2009	Moreover, knockdown of STAT5a was associated with a concurrent silencing of morphine-induced expression of cyclin D1, demonstrating involvement of STAT5a in morphine-triggered signaling in the regulation of cyclin D1 expression.	Morphine	157-165	cyclin D1	Homo sapiens	207-216
19426693-9	2009	Thus, we conclude that morphine may modulate cyclin D1 gene expression via signal transducers and activators of transcription (STATs) signaling, which will be beneficial for further understanding of the pharmacological effect of morphine on immune regulation.	Morphine	23-31	cyclin D1	Homo sapiens	45-54
19426693-9	2009	Thus, we conclude that morphine may modulate cyclin D1 gene expression via signal transducers and activators of transcription (STATs) signaling, which will be beneficial for further understanding of the pharmacological effect of morphine on immune regulation.	Morphine	229-237	cyclin D1	Homo sapiens	45-54
19177142-4	2009	Induction of cell-cycle arrest by ciglitazone is associated with changes in expression of key cell-cycle regulators such as p21, cyclin D1, and pRB hypophosphorylation.	ciglitazone	34-45	cyclin D1	Homo sapiens	129-138
19126643-10	2009	More importantly, using the tet-on overexpression system, we showed that induced expression of CCDC62/ERAP75 can enhance the E2-regulated cyclin D1 expression and cell growth in LNCaP cells.	tetramethylenedisulfotetramine	28-31	cyclin D1	Homo sapiens	138-147
19476491-8	2009	The hairpin STAT3 oligodeoxynucleotide co-localized with STAT3 within the cytoplasm, prevented STAT3 localization to the nucleus, blocked a cyclin D1 reporter promoter and associated with STAT3 in pull-down assays.	Oligodeoxyribonucleotides	18-38	cyclin D1	Homo sapiens	140-149
19269999-0	2009	Penta-O-galloyl-beta-D-glucose induces S- and G(1)-cell cycle arrests in prostate cancer cells targeting DNA replication and cyclin D1.	penta-o-galloyl-beta-d-glucose	0-30	cyclin D1	Homo sapiens	125-134
19269999-7	2009	In addition to the S-arrest action, we have found a close association of downregulation of cyclin D1 with G(1) arrest induced by PGG.	beta-penta-O-galloyl-glucose	129-132	cyclin D1	Homo sapiens	91-100
19269999-9	2009	Together, our data indicate that PGG induced PCa S-arrest probably through DNA replicative blockage and induced G(1) arrest via cyclin D1 downregulation to contribute to anticancer activity.	beta-penta-O-galloyl-glucose	33-36	cyclin D1	Homo sapiens	128-137
19191010-7	2009	Curcumin acts as an anti-inflammatory and anti-proliferative agent by causing down regulation of COX-2, iNOS and cyclin D1 in all the three cell lines but to different extent.	Curcumin	0-8	cyclin D1	Homo sapiens	113-122
19091460-7	2009	The hexachlorophene modulation of Siah-1 and beta-catenin is independent of p53 and results in reduced expression of cyclin-D1 and c-Myc (target genes of beta-catenin), leading to the growth arrest of B lymphoma cells.	Hexachlorophene	4-19	cyclin D1	Homo sapiens	117-126
19417153-13	2009	PI-103 abrogated MPNST cell growth and induced G(1) cell cycle arrest potentially through repression of cyclin D1.	PI103	0-6	cyclin D1	Homo sapiens	104-113
19318573-4	2009	In our current study, we found that TW-37 induces cell growth inhibition and S-phase cell cycle arrest, with regulation of several important cell cycle-related genes like p27, p57, E2F-1, cdc25A, CDK4, cyclin A, cyclin D1, and cyclin E. The cell growth inhibition was accompanied by increased apoptosis with concomitant attenuation of Notch-1, Jagged-1, and its downstream genes such as Hes-1 in vitro and in vivo.	TW-37	36-41	cyclin D1	Homo sapiens	212-221
19317806-7	2009	Silymarin also decreased mitochondrial transmembrane potential of the cells, thereby increasing levels of cytosolic cytochrome c while up-regulating expression of pro-apoptotic proteins (such as p53, Bax, APAF-1 and caspase-3) with concomitant decrease in anti-apoptotic proteins (Bcl-2 and survivin) and proliferation-associated proteins (beta-catenin, cyclin D1, c-Myc and PCNA).	Silymarin	0-9	cyclin D1	Homo sapiens	354-363
19136653-6	2009	Human islets transduced with cdk-6 and cyclin D1 were transplanted into diabetic NOD-SCID mice and markedly outperformed native human islets in vivo, maintaining glucose control for the entire 6 weeks of the study.	Glucose	162-169	cyclin D1	Homo sapiens	39-48
19032445-11	2009	The addition of 1 microM GABA predominantly activated ERK-1/2 among the three MAP kinases in addition to increasing cyclin D1 expression.	gamma-Aminobutyric Acid	25-29	cyclin D1	Homo sapiens	116-125
19372569-4	2009	Curcumin also potentiated the apoptotic effects of thalidomide and bortezomib by down-regulating the constitutive activation of NF-kappaB and Akt, and this correlated with the suppression of NF-kappaB-regulated gene products, including cyclin D1, Bcl-xL, Bcl-2, TRAF1, cIAP-1, XIAP, survivin, and vascular endothelial growth factor.	Curcumin	0-8	cyclin D1	Homo sapiens	236-245
19211828-6	2009	Enterolactone also inhibited cyclin D1 expression.	2,3-bis(3'-hydroxybenzyl)butyrolactone	0-13	cyclin D1	Homo sapiens	29-38
19361625-7	2009	RESULTS: In vitro, the BPA group had 20% higher number of viable cells, 70% higher proliferation index (both P &lt; .01), and higher expression of cyclin-dependent kinase 4 and cyclin D1 than the nontreated group.	bisphenol A	23-26	cyclin D1	Homo sapiens	177-186
19372569-4	2009	Curcumin also potentiated the apoptotic effects of thalidomide and bortezomib by down-regulating the constitutive activation of NF-kappaB and Akt, and this correlated with the suppression of NF-kappaB-regulated gene products, including cyclin D1, Bcl-xL, Bcl-2, TRAF1, cIAP-1, XIAP, survivin, and vascular endothelial growth factor.	Thalidomide	51-62	cyclin D1	Homo sapiens	236-245
19372569-4	2009	Curcumin also potentiated the apoptotic effects of thalidomide and bortezomib by down-regulating the constitutive activation of NF-kappaB and Akt, and this correlated with the suppression of NF-kappaB-regulated gene products, including cyclin D1, Bcl-xL, Bcl-2, TRAF1, cIAP-1, XIAP, survivin, and vascular endothelial growth factor.	Bortezomib	67-77	cyclin D1	Homo sapiens	236-245
19499806-2	2009	Cyclin D1-DRz were transfected into tumor cell line u251 and HeLa by oligofectamine.	oligofectamine	69-83	cyclin D1	Homo sapiens	0-9
19158360-4	2009	Expression of the NF-kappaB targeting genes cyclin D1, vascular endothelial growth factor, and urokinase-type plasminogen activator is significantly reduced by triptolide in both TA-K and 8505C human ATC cell lines, which are well known to be critical for proliferation, angiogenesis, and invasion in solid tumors.	triptolide	160-170	cyclin D1	Homo sapiens	44-53
19639794-3	2009	RESULT: After treatment with resveratrol, MTT assay showed the growth of U251 cells was inhibited in dose-dependent and time-dependent manners, apoptosis of cells advanced stage was built up, immunohistochemical staining displayed decreased the expression of Bcl-2, Bcl-XL, STAT3 and CyclinD1 and Western blot showed that resveratrol decreased the expression of Bcl-2, Bcl-XL, STAT3 and CyclinD1, and built up Bax and Caspase-3.	Resveratrol	29-40	cyclin D1	Homo sapiens	284-292
19379572-6	2009	PCR results showed the down-regulation of mTOR, cyclin D1 and mTOR mRNA expressions after treating RPMI8226 cells with different concentrations of rapamycin for 24 hours.	Sirolimus	147-156	cyclin D1	Homo sapiens	48-57
19639794-3	2009	RESULT: After treatment with resveratrol, MTT assay showed the growth of U251 cells was inhibited in dose-dependent and time-dependent manners, apoptosis of cells advanced stage was built up, immunohistochemical staining displayed decreased the expression of Bcl-2, Bcl-XL, STAT3 and CyclinD1 and Western blot showed that resveratrol decreased the expression of Bcl-2, Bcl-XL, STAT3 and CyclinD1, and built up Bax and Caspase-3.	Resveratrol	29-40	cyclin D1	Homo sapiens	387-395
19142877-5	2009	RESULTS: The positivity for total p53, RARbeta, cyclin D1, and PCNA was nonsignificantly lower among lung cancer patients who were assigned to receive beta-carotene than those who were assigned to receive beta-carotene placebo.	beta Carotene	151-164	cyclin D1	Homo sapiens	48-57
19198627-0	2009	Styryl sulfonyl compounds inhibit translation of cyclin D1 in mantle cell lymphoma cells.	styryl sulfonyl compounds	0-25	cyclin D1	Homo sapiens	49-58
19198627-4	2009	Here, we show that the prototypical styryl sulfonyl compound ON 01910.Na decreased cyclin D1 and c-Myc protein levels in MCL cells, whereas mRNA levels of cyclin D1 were minimally affected.	styryl sulfonyl	36-51	cyclin D1	Homo sapiens	83-92
19198627-4	2009	Here, we show that the prototypical styryl sulfonyl compound ON 01910.Na decreased cyclin D1 and c-Myc protein levels in MCL cells, whereas mRNA levels of cyclin D1 were minimally affected.	styryl sulfonyl	36-51	cyclin D1	Homo sapiens	155-164
19198627-7	2009	Taken together, styryl sulfonyls can cause a rapid decrease of cyclin D1 by blocking cyclin D1 mRNA translation through inhibition of the PI-3K/Akt/mTOR/eIF4E-BP signaling pathway and triggering a cytochrome c-dependent apoptotic pathway in MCL cells.	styryl sulfonyls	16-32	cyclin D1	Homo sapiens	63-72
19198627-7	2009	Taken together, styryl sulfonyls can cause a rapid decrease of cyclin D1 by blocking cyclin D1 mRNA translation through inhibition of the PI-3K/Akt/mTOR/eIF4E-BP signaling pathway and triggering a cytochrome c-dependent apoptotic pathway in MCL cells.	styryl sulfonyls	16-32	cyclin D1	Homo sapiens	85-94
19221498-6	2009	At the molecular level, metformin treatment was associated with a reduction of cyclin D1 and E2F1 expression with no changes in p27(kip1) or p21(waf1).	Metformin	24-33	cyclin D1	Homo sapiens	79-88
19182994-7	2009	Ha-ras-induced Stat3 phosphorylation at serine-727 plays a pivotal role in transcriptional activation of cyclin D1 and suppression of cell apoptosis.	Serine	40-46	cyclin D1	Homo sapiens	105-114
18852162-2	2009	The E(2)-induced proliferation was associated with the activation of extracellular signal-regulated kinase (MAPK)3/1 and up-regulation of cyclin D1 and E, which were suppressed by the addition of an MAP2K inhibitor (U0126) or an ER antagonist (ICI 182 780).	U 0126	216-221	cyclin D1	Homo sapiens	138-153
19086036-1	2009	UNLABELLED: Toxic bile acids induce hepatocyte apoptosis, for which p53 and cyclin D1 have been implicated as underlying mediators.	Bile Acids and Salts	18-28	cyclin D1	Homo sapiens	76-85
19070887-7	2009	The findings suggest that a thalidomide-based regimen may overcome the poor prognosis associated with a cyclin D1-negative or fibroblast growth factor receptor 3-positive phenotype.	Thalidomide	28-39	cyclin D1	Homo sapiens	104-113
18988190-6	2009	Mutagenesis studies, eletrophoretic mobility shift, and chromatin immunoprecipitation analysis revealed that signal transducers and activators of transcription 3 (STAT3) and cyclic AMP-responsive element (CRE) binding protein motifs, within cyclin D1 promoter, were required for leptin-induced cyclin D1 expression in Ishikawa endometrial cancer cells.	Cyclic AMP	174-184	cyclin D1	Homo sapiens	241-250
18988190-6	2009	Mutagenesis studies, eletrophoretic mobility shift, and chromatin immunoprecipitation analysis revealed that signal transducers and activators of transcription 3 (STAT3) and cyclic AMP-responsive element (CRE) binding protein motifs, within cyclin D1 promoter, were required for leptin-induced cyclin D1 expression in Ishikawa endometrial cancer cells.	Cyclic AMP	174-184	cyclin D1	Homo sapiens	294-303
19034928-0	2009	Butyrate and vitamin D3 induce transcriptional attenuation at the cyclin D1 locus in colonic carcinoma cells.	Butyrates	0-8	cyclin D1	Homo sapiens	66-75
19034928-0	2009	Butyrate and vitamin D3 induce transcriptional attenuation at the cyclin D1 locus in colonic carcinoma cells.	Cholecalciferol	13-23	cyclin D1	Homo sapiens	66-75
19034928-1	2009	In stimulating maturation of colonic carcinoma cells, the short chain fatty acid butyrate, and 1alpha,25-dihydroxyvitamin D(3), were shown to attenuate transcription of the cyclin D1 gene, giving rise to truncated transcripts of this locus.	short chain fatty acid butyrate	58-89	cyclin D1	Homo sapiens	173-182
19034928-1	2009	In stimulating maturation of colonic carcinoma cells, the short chain fatty acid butyrate, and 1alpha,25-dihydroxyvitamin D(3), were shown to attenuate transcription of the cyclin D1 gene, giving rise to truncated transcripts of this locus.	1,25-dihydroxyvitamin D	95-123	cyclin D1	Homo sapiens	173-182
19276161-5	2009	On the other hand, both Se forms decreased the expression of cyclin D1 and increased levels of P27Kip1 and c-Jun NH2-terminal kinase activation in a majority of the mammary carcinomas.	Selenium	24-26	cyclin D1	Homo sapiens	61-70
19276161-7	2009	In summary, these experiments showed the induction of cancer epithelial cell apoptosis and inhibition of cell proliferation by Se in vivo through the potential involvement of cyclin D1, P27Kip1, and c-Jun NH2-terminal kinase pathways.	Selenium	127-129	cyclin D1	Homo sapiens	175-184
19196980-4	2009	Paradoxically, the GSK3beta inhibitors lithium chloride and SB216763 selectively decreased the proliferation of human breast and colorectal cancer cell lines with oncogenic PIK3CA mutations and led to a decrease in the GSK3beta target gene CYCLIN D1.	Lithium Chloride	39-55	cyclin D1	Homo sapiens	240-249
19196980-4	2009	Paradoxically, the GSK3beta inhibitors lithium chloride and SB216763 selectively decreased the proliferation of human breast and colorectal cancer cell lines with oncogenic PIK3CA mutations and led to a decrease in the GSK3beta target gene CYCLIN D1.	SB 216763	60-68	cyclin D1	Homo sapiens	240-249
18926623-5	2009	Partially, 5"-NIO also arrested cell cycle in G1/S phase via the reduction of CDK4 and cyclin D1/D3 levels by p16 and induction of the level of p21waf1.	5'-nitroindirubinoxime	11-17	cyclin D1	Homo sapiens	87-96
19124461-8	2009	The proline-rich N-terminal portion of INSM1 is required for cyclin D1 binding.	Proline	4-11	cyclin D1	Homo sapiens	61-70
19124461-9	2009	Mutation of proline residues abolished cyclin D1 binding and also diminished its ability to induce cell cycle arrest.	Proline	12-19	cyclin D1	Homo sapiens	39-48
18938028-4	2009	The association between phospho-pRb (Ser-807/811) levels and exposure to tobacco smoke was different according to the statuses of cyclin D1 expression and p16 methylation, suggesting that their statuses might play a role as an effect modifier in the relationship between phospho-pRb (Ser-807/811) levels and exposure to tobacco smoke.	Serine	37-40	cyclin D1	Homo sapiens	130-139
19086036-9	2009	Lithocholic acid (LCA) treatment of primary human hepatocytes and HuH-7 cells induced a similar switch from Mnt to Myc and increased p53 and cyclin D1 promoter activity and endogenous p53 and cyclin D1 expression and apoptosis.	Lithocholic Acid	0-16	cyclin D1	Homo sapiens	141-150
19086036-9	2009	Lithocholic acid (LCA) treatment of primary human hepatocytes and HuH-7 cells induced a similar switch from Mnt to Myc and increased p53 and cyclin D1 promoter activity and endogenous p53 and cyclin D1 expression and apoptosis.	Lithocholic Acid	0-16	cyclin D1	Homo sapiens	192-201
19086036-9	2009	Lithocholic acid (LCA) treatment of primary human hepatocytes and HuH-7 cells induced a similar switch from Mnt to Myc and increased p53 and cyclin D1 promoter activity and endogenous p53 and cyclin D1 expression and apoptosis.	Lithocholic Acid	18-21	cyclin D1	Homo sapiens	141-150
19086036-9	2009	Lithocholic acid (LCA) treatment of primary human hepatocytes and HuH-7 cells induced a similar switch from Mnt to Myc and increased p53 and cyclin D1 promoter activity and endogenous p53 and cyclin D1 expression and apoptosis.	Lithocholic Acid	18-21	cyclin D1	Homo sapiens	192-201
19086036-10	2009	Blocking c-Myc induction in HuH-7 cells prevented the LCA-mediated increase in p53 and cyclin D1 expression and reduced apoptosis.	Lithocholic Acid	54-57	cyclin D1	Homo sapiens	87-96
19086036-11	2009	Lowering Mnt expression further enhanced LCA"s inductive effect on p53 and cyclin D1.	Lithocholic Acid	41-44	cyclin D1	Homo sapiens	75-84
19086036-13	2009	CONCLUSION: The switch from Mnt to Myc during bile duct ligation and in hepatocytes treated with LCA is responsible for the induction in p53 and cyclin D1 expression and contributes to apoptosis.	Lithocholic Acid	97-100	cyclin D1	Homo sapiens	145-154
18803287-7	2008	In parallel, gefitinib downregulated constitutively phosphorylated HER2 and HER3, and activated GSK3beta with a concomitant degradation of cyclin D1.	Gefitinib	13-22	cyclin D1	Homo sapiens	139-148
19037088-7	2009	Treatment of cells with fisetin also inhibited Wnt-signaling activity through downregulation of beta-catenin and T cell factor 4 and decreased the expression of target genes such as cyclin D1 and matrix metalloproteinase 7.	fisetin	24-31	cyclin D1	Homo sapiens	182-191
19374252-3	2009	In this study, working on the genotoxic stress induced by hydroxyurea and methylmethanesulfone, we observed a growth arrest at G1/S-phase that was mediated by destabilization of cyclin D1.	Hydroxyurea	58-69	cyclin D1	Homo sapiens	178-187
19374252-3	2009	In this study, working on the genotoxic stress induced by hydroxyurea and methylmethanesulfone, we observed a growth arrest at G1/S-phase that was mediated by destabilization of cyclin D1.	methylmethanesulfone	74-94	cyclin D1	Homo sapiens	178-187
19374252-5	2009	Cyclin D1 destabilization involved its phosphorylation by GSK-3beta at threonine-286, since overexpression of the kinase-dead mutant of GSK-3beta or cyclin D1T(286A) Inutant conferred stability to cyclin D1.	Threonine	71-80	cyclin D1	Homo sapiens	0-9
19148524-6	2009	The G1 phase arrest is associated with down-regulation of Cyclin D1/Cdk4 and Cyclin B1/Cdc2 activities in cells after treatment with KG-135.	kg-135	133-139	cyclin D1	Homo sapiens	58-67
19148524-8	2009	In addition, the decrease in the levels of Cyclin D1/Cdk4 and Cyclin B1, but not of Cdc2, is similarly prevented by co-treatment of cells with MG-132, a potent proteasome inhibitor.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	143-149	cyclin D1	Homo sapiens	43-52
19148524-9	2009	Thus, the KG-135-induced arrest of the cell cycle at G1 phase in HeLa cells represents a novel mechanism that involves proteasome-mediated degradation of the Cyclins (Cyclin D1 and B1) and Cdk4 proteins.	kg-135	10-16	cyclin D1	Homo sapiens	167-184
19071090-6	2009	Interestingly, after mutation of threonine residue 286 of cyclin D1, which is reported to be the GSK-3beta phosphorylation site, the mutant protein showed resistance to irradiation-induced proteolysis although inhibitors of GSK-3beta failed to prevent cyclin D1 degradation.	Threonine	33-42	cyclin D1	Homo sapiens	58-67
19071090-6	2009	Interestingly, after mutation of threonine residue 286 of cyclin D1, which is reported to be the GSK-3beta phosphorylation site, the mutant protein showed resistance to irradiation-induced proteolysis although inhibitors of GSK-3beta failed to prevent cyclin D1 degradation.	Threonine	33-42	cyclin D1	Homo sapiens	252-261
18942709-0	2009	Inhibition of cyclin D1 expression by cyclin D1 shRNAs in human oral squamous cell carcinoma cells is associated with increased cisplatin chemosensitivity.	Cisplatin	128-137	cyclin D1	Homo sapiens	14-23
18942709-0	2009	Inhibition of cyclin D1 expression by cyclin D1 shRNAs in human oral squamous cell carcinoma cells is associated with increased cisplatin chemosensitivity.	Cisplatin	128-137	cyclin D1	Homo sapiens	38-47
18942709-3	2009	Because increasing expression of cyclin D1 is a common event in oral squamous cell carcinoma (OSCC) and has been correlated with cisplatin resistance, we investigated if cyclin D1 inhibition could increase cisplatin chemosensitivity of OSCC.	Cisplatin	129-138	cyclin D1	Homo sapiens	33-42
18942709-3	2009	Because increasing expression of cyclin D1 is a common event in oral squamous cell carcinoma (OSCC) and has been correlated with cisplatin resistance, we investigated if cyclin D1 inhibition could increase cisplatin chemosensitivity of OSCC.	Cisplatin	206-215	cyclin D1	Homo sapiens	170-179
18942709-8	2009	The role of nuclear factor-kappaB (NF-kappaB) and cyclin-dependent kinase 4 (CDK4) in cyclin D1-mediated cisplatin resistance was also examined.	Cisplatin	105-114	cyclin D1	Homo sapiens	86-95
18942709-10	2009	After the transfection with the 2 most effective shRNAs, the cisplatin IC50 decreased from 5.88 microg/ml to 1.36 microg/ml and 2.47 microg/ml, although overexpression of cyclin D1 rendered OSCC cells more resistant to cisplatin treatment (IC50 increased from 6.43 microg/ml to 12.24 microg/ml).	Cisplatin	61-70	cyclin D1	Homo sapiens	171-180
18942709-10	2009	After the transfection with the 2 most effective shRNAs, the cisplatin IC50 decreased from 5.88 microg/ml to 1.36 microg/ml and 2.47 microg/ml, although overexpression of cyclin D1 rendered OSCC cells more resistant to cisplatin treatment (IC50 increased from 6.43 microg/ml to 12.24 microg/ml).	Cisplatin	219-228	cyclin D1	Homo sapiens	171-180
18942709-11	2009	This decreasing IC50 was correlated with the down-regulation of cisplatin-induced NF-kappaB activity in cyclin D1 knockdown cells, and was independent of CDK4 function.	Cisplatin	64-73	cyclin D1	Homo sapiens	104-113
18942709-12	2009	In vivo tumor transplantation models also confirmed a cisplatin-sensitizing effect of cyclin D1 shRNA in OSCC.	Cisplatin	54-63	cyclin D1	Homo sapiens	86-95
18942709-13	2009	A TUNEL assay validated the increase in apoptosis as induced by cisplatin in cyclin D1 knockdown cells.	Cisplatin	64-73	cyclin D1	Homo sapiens	77-86
19091560-0	2009	Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of Cyclin D1-CDK4: synthesis, biological evaluation, and structure-activity relationships.	thieno[2,3-d]pyrimidin-4-yl hydrazone	19-56	cyclin D1	Homo sapiens	77-86
19164938-5	2009	Western blot analysis revealed that growth inhibitory concentrations of the TZDs rosiglitazone and ciglitazone induced expression of the cyclin dependent kinase inhibitor p21 and decreased cyclin D1 levels in the androgen independent PC-3 cell line.	Rosiglitazone	81-94	cyclin D1	Homo sapiens	189-198
19164938-5	2009	Western blot analysis revealed that growth inhibitory concentrations of the TZDs rosiglitazone and ciglitazone induced expression of the cyclin dependent kinase inhibitor p21 and decreased cyclin D1 levels in the androgen independent PC-3 cell line.	ciglitazone	99-110	cyclin D1	Homo sapiens	189-198
19164938-7	2009	Furthermore, growth inhibitory concentrations of ciglitazone increased p21 and lowered cyclin D1 expression within C4-2 cells.	ciglitazone	49-60	cyclin D1	Homo sapiens	87-96
19164938-8	2009	PPARgamma-directed siRNAs inhibited the ability of rosiglitazone to regulate expression of cyclin D1 and p21.	Rosiglitazone	51-64	cyclin D1	Homo sapiens	91-100
18228136-12	2009	In conclusion, 2ME chemosensitizes resistant breast cancer cells to Dox cytotoxicity by down regulating expression of Bcl2 and Cyclin D1, augmenting caspase 3 activity as well as inducing cell cycle block in G(1) and S phases.	Doxorubicin	68-71	cyclin D1	Homo sapiens	127-136
19207549-0	2009	Influence of aspirin and cigarette smoke extract on the expression of cyclin D1 and effects of cell cycle in esophageal squamous cell carcinoma cell line.	Aspirin	13-20	cyclin D1	Homo sapiens	70-79
19207549-6	2009	However, aspirin can inhibit the cell growth and suppress the protein level of cyclin D(1) after CSE affected the EC109 cell line in a dose-dependent manner (P &lt; 0.01).	Aspirin	9-16	cyclin D1	Homo sapiens	79-90
19207549-8	2009	Aspirin can inhibit the cell growth and suppress the protein level of cyclin D(1) after CSE affected EC109 cell line.	Aspirin	0-7	cyclin D1	Homo sapiens	70-81
19052819-0	2009	Diazoxide-mediated growth inhibition in human lung cancer cells via downregulation of beta-catenin-mediated cyclin D1 transcription.	Diazoxide	0-9	cyclin D1	Homo sapiens	108-117
19052819-3	2009	Here we demonstrate that diazoxide inhibited the proliferation of lung cancer cells as well as the transcription of cell cycle-related protein Cyclin D1.	Diazoxide	25-34	cyclin D1	Homo sapiens	143-152
19052819-4	2009	Cyclin D1 overexpression inhibited the negative role of diazoxide in cell cycle progression.	Diazoxide	56-65	cyclin D1	Homo sapiens	0-9
19052819-5	2009	We further explored the mechanisms by which diazoxide affected Cyclin D1 transcription and found that the beta-catenin transcription factor was downregulated by diazoxide, with a corresponding decrease in Cyclin D1 promoter activity.	Diazoxide	44-53	cyclin D1	Homo sapiens	63-72
19052819-5	2009	We further explored the mechanisms by which diazoxide affected Cyclin D1 transcription and found that the beta-catenin transcription factor was downregulated by diazoxide, with a corresponding decrease in Cyclin D1 promoter activity.	Diazoxide	44-53	cyclin D1	Homo sapiens	205-214
19052819-5	2009	We further explored the mechanisms by which diazoxide affected Cyclin D1 transcription and found that the beta-catenin transcription factor was downregulated by diazoxide, with a corresponding decrease in Cyclin D1 promoter activity.	Diazoxide	161-170	cyclin D1	Homo sapiens	63-72
19052819-6	2009	Taken together, these results suggest that diazoxide inhibits lung cancer cell proliferation via downregulation of Cyclin D1 transcription, which may have important therapeutic implications in lung cancer patients.	Diazoxide	43-52	cyclin D1	Homo sapiens	115-124
19838939-8	2009	Cyclin D1, cyclin D3, bcl-2, and NFkappa B proteins were found to be downregulated following gamma-tocopherol treatment.	gamma-Tocopherol	93-109	cyclin D1	Homo sapiens	0-9
19115995-5	2008	The expression levels of PTEN- and P27kip1- mRNA were up-regulated, and the mTOR- and cyclinD1- mRNA were down-regulated in K562 cells after the cells transfected with wild type PTEN gene and treated with rapamycin.	Sirolimus	205-214	cyclin D1	Homo sapiens	86-94
18450412-8	2009	Indirubin-3-oxime-induced growth inhibition was associated with induction of Cdk inhibitor p21, inhibition of cyclin D1 and activation of caspase-3.	indirubin-3'-monoxime	0-17	cyclin D1	Homo sapiens	110-119
19236511-6	2009	Cyclin D1, p21 and cyclin A were overexpressed in 58.6%, 51.7% and 31.8% of the NAA cases, respectively, whereas 81.3%, 62.5% and 41.7% of the AAA cases showed overexpression of cyclin D1, p21 and cyclin A, respectively.	1-naphthaleneacetic acid	80-83	cyclin D1	Homo sapiens	0-9
19148492-7	2009	Treatment with 17-AAG also caused down-regulation of cyclin D1, GADD45a, GADD34 and pCdc2 and upregulation of cyclin B1 and mitotic block.	tanespimycin	15-21	cyclin D1	Homo sapiens	53-62
19094964-6	2009	In parallel, ZSTK474 treatment suppressed the expression of phospho-Akt, suggesting effective PI3K inhibition, and also suppressed the expression of nuclear cyclin D1 and Ki67, both of which are hallmarks of proliferation.	ZSTK474	13-20	cyclin D1	Homo sapiens	157-166
19041854-8	2009	After the NMDA treatment, cyclin D1 levels increased after a short delay (4 h), but fell back to control levels after 20 h. The effects of NMDA and KLF4 overexpression on cyclin D1 induction were additive.	N-Methylaspartate	10-14	cyclin D1	Homo sapiens	26-35
19041854-8	2009	After the NMDA treatment, cyclin D1 levels increased after a short delay (4 h), but fell back to control levels after 20 h. The effects of NMDA and KLF4 overexpression on cyclin D1 induction were additive.	N-Methylaspartate	10-14	cyclin D1	Homo sapiens	171-180
19041854-8	2009	After the NMDA treatment, cyclin D1 levels increased after a short delay (4 h), but fell back to control levels after 20 h. The effects of NMDA and KLF4 overexpression on cyclin D1 induction were additive.	N-Methylaspartate	139-143	cyclin D1	Homo sapiens	26-35
19041854-8	2009	After the NMDA treatment, cyclin D1 levels increased after a short delay (4 h), but fell back to control levels after 20 h. The effects of NMDA and KLF4 overexpression on cyclin D1 induction were additive.	N-Methylaspartate	139-143	cyclin D1	Homo sapiens	171-180
19141783-7	2009	Lapatinib also effectively blocked epidermal growth factor-induced signaling through the EGFR and ErbB2 receptors, suppressed cyclin D1 and epiregulin mRNA expression, and stimulated p27 mRNA expression in human mammary epithelial cells and in mammary epithelial cells from mice treated for 5 months with high-dose lapatinib.	Lapatinib	0-9	cyclin D1	Homo sapiens	126-135
19141783-8	2009	Thus, cyclin D1, epiregulin, and p27 may represent useful biomarkers of lapatinib response in patients.	Lapatinib	72-81	cyclin D1	Homo sapiens	6-15
18805632-9	2009	These findings along with the temporal sequence of individual changes indicate a signaling sequence that involves ROS--&gt;MAPKs--&gt;p21(cip-1)--&gt;cyclin D1--&gt;cell death.	Reactive Oxygen Species	114-117	cyclin D1	Homo sapiens	150-159
18824293-4	2009	RAD001 in combination with cisplatin induced a significant increase in the number of apoptotic cells, downregulated the expression of pro-survival molecules, Bcl-2, survivin and cyclinD1, and increased the cleavage of PARP, compared to RAD001 or cisplatin alone.	Cisplatin	27-36	cyclin D1	Homo sapiens	178-186
19147768-0	2009	Polyphenon E inhibits the growth of human Barrett"s and aerodigestive adenocarcinoma cells by suppressing cyclin D1 expression.	polyphenon E	0-12	cyclin D1	Homo sapiens	106-115
19147768-5	2009	RESULTS: Poly E inhibited the proliferation of immortalized Barrett"s cells as well as various adenocarcinoma cells, and this was associated with the down-regulation of cyclin D1 protein expression.	polyphenon E	9-15	cyclin D1	Homo sapiens	169-178
19147768-7	2009	Poly E down-regulated cyclin D1 promoter activity and mRNA expression, suggesting transcriptional repression, and this correlated with decreased nuclear beta-catenin and beta-catenin/TCF4 transcriptional activity.	polyphenon E	0-6	cyclin D1	Homo sapiens	22-31
19147768-8	2009	MG132, an inhibitor of 26S proteosome, blocked the Poly E-induced down-regulation of cyclin D1, and Poly E promoted cyclin D1 polyubiquitination, suggesting that Poly E also inhibits cyclin D1 expression by promoting its degradation.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	0-5	cyclin D1	Homo sapiens	85-94
19147768-8	2009	MG132, an inhibitor of 26S proteosome, blocked the Poly E-induced down-regulation of cyclin D1, and Poly E promoted cyclin D1 polyubiquitination, suggesting that Poly E also inhibits cyclin D1 expression by promoting its degradation.	polyphenon E	51-57	cyclin D1	Homo sapiens	85-94
19147768-8	2009	MG132, an inhibitor of 26S proteosome, blocked the Poly E-induced down-regulation of cyclin D1, and Poly E promoted cyclin D1 polyubiquitination, suggesting that Poly E also inhibits cyclin D1 expression by promoting its degradation.	polyphenon E	100-106	cyclin D1	Homo sapiens	116-125
19147768-8	2009	MG132, an inhibitor of 26S proteosome, blocked the Poly E-induced down-regulation of cyclin D1, and Poly E promoted cyclin D1 polyubiquitination, suggesting that Poly E also inhibits cyclin D1 expression by promoting its degradation.	polyphenon E	100-106	cyclin D1	Homo sapiens	116-125
19147768-8	2009	MG132, an inhibitor of 26S proteosome, blocked the Poly E-induced down-regulation of cyclin D1, and Poly E promoted cyclin D1 polyubiquitination, suggesting that Poly E also inhibits cyclin D1 expression by promoting its degradation.	polyphenon E	100-106	cyclin D1	Homo sapiens	116-125
19147768-8	2009	MG132, an inhibitor of 26S proteosome, blocked the Poly E-induced down-regulation of cyclin D1, and Poly E promoted cyclin D1 polyubiquitination, suggesting that Poly E also inhibits cyclin D1 expression by promoting its degradation.	polyphenon E	100-106	cyclin D1	Homo sapiens	116-125
19147768-9	2009	CONCLUSION: Poly E inhibits growth of transformed aerodigestive epithelial cells by suppressing cyclin D1 expression through both transcriptional and posttranslational mechanisms.	polyphenon E	12-18	cyclin D1	Homo sapiens	96-105
19134194-6	2009	In the TMAs, eIF4E levels correlated strongly with c-Myc, cyclin D1, TLK1B, VEGF, and ODC.	4,4-dimethylcholesta-8,14-dien-3-ol	7-11	cyclin D1	Homo sapiens	58-67
18957410-1	2009	The synthetic rexinoid bexarotene (Targretin, LGD1069) inhibits the formation of both estrogen receptor-negative and estrogen receptor-positive breast cancer in preclinical models and controls the expression of growth-regulatory biomarkers, such as IGFBP-6 (insulin-like growth factor-binding protein 6), RARbeta, or cyclin D1.	rexinoid	14-22	cyclin D1	Homo sapiens	317-326
18957410-1	2009	The synthetic rexinoid bexarotene (Targretin, LGD1069) inhibits the formation of both estrogen receptor-negative and estrogen receptor-positive breast cancer in preclinical models and controls the expression of growth-regulatory biomarkers, such as IGFBP-6 (insulin-like growth factor-binding protein 6), RARbeta, or cyclin D1.	Bexarotene	23-33	cyclin D1	Homo sapiens	317-326
18957410-1	2009	The synthetic rexinoid bexarotene (Targretin, LGD1069) inhibits the formation of both estrogen receptor-negative and estrogen receptor-positive breast cancer in preclinical models and controls the expression of growth-regulatory biomarkers, such as IGFBP-6 (insulin-like growth factor-binding protein 6), RARbeta, or cyclin D1.	Bexarotene	35-44	cyclin D1	Homo sapiens	317-326
18228136-4	2009	RT(2) Profiler PCR Array was used to identify differentially expressed genes in Dox and/or 2ME treatment groups, based on significance of results 4 genes were selected: MDR1, Bcl2, P53 and Cyclin D1.	Doxorubicin	80-83	cyclin D1	Homo sapiens	189-198
18228136-8	2009	The array and western blotting showed that Bcl2 and Cyclin D1 expression were down regulated; P53 expression was not affected while MDR1 was over expressed by combination of 2ME with Dox.	Doxorubicin	183-186	cyclin D1	Homo sapiens	52-61
19139010-0	2009	Retinoid chemoprevention trials: cyclin D1 in the crosshairs.	Retinoids	0-8	cyclin D1	Homo sapiens	33-42
18792914-0	2009	Soluble and insoluble nickel compounds exert a differential inhibitory effect on cell growth through IKKalpha-dependent cyclin D1 down-regulation.	Nickel	22-28	cyclin D1	Homo sapiens	120-129
18792914-4	2009	The down-regulation of cyclin D1 is due to protein degradation rather than inhibition of transcription, because the nickel compounds treatment did not change cyclin D1 mRNA level, while MG132, the proteasome inhibitor, can rescue the degradation of cyclin D1 caused by soluble nickel compound.	Nickel	116-122	cyclin D1	Homo sapiens	23-32
18792914-4	2009	The down-regulation of cyclin D1 is due to protein degradation rather than inhibition of transcription, because the nickel compounds treatment did not change cyclin D1 mRNA level, while MG132, the proteasome inhibitor, can rescue the degradation of cyclin D1 caused by soluble nickel compound.	Nickel	277-283	cyclin D1	Homo sapiens	23-32
18792914-5	2009	Moreover, the soluble nickel-induced cyclin D1 degradation is dependent on its Thr286 residue and requires IKKalpha, but not HIF-1alpha, which are both reported to be involved in cyclin D1 down-regulation.	Nickel	22-28	cyclin D1	Homo sapiens	37-46
18792914-5	2009	Moreover, the soluble nickel-induced cyclin D1 degradation is dependent on its Thr286 residue and requires IKKalpha, but not HIF-1alpha, which are both reported to be involved in cyclin D1 down-regulation.	Nickel	22-28	cyclin D1	Homo sapiens	179-188
18792914-7	2009	Given the role of cyclin D1 and cell proliferation in carcinogenesis, we anticipate that the different effects of soluble and insoluble nickel compounds on cyclin D1 degradation and cell growth arrest may at least partially account for their different carcinogenic activities.	Nickel	136-142	cyclin D1	Homo sapiens	156-165
19738389-7	2009	Treatment with cyclopamine inhibited the proliferation and colony formation of ONB cells, induced ONB cell cycle arrest and apoptosis, and down-regulated the expression of Pacthed1, Gli1 and cyclin D1, but up-regulated p21 expression in vitro.	cyclopamine	15-26	cyclin D1	Homo sapiens	191-200
19440292-4	2009	The expression of Stat3-regulated proteins such as c-myc, cyclin D1, Bcl2, survivin and VEGF were reduced in response to avicin treatment.	avicin	121-127	cyclin D1	Homo sapiens	58-67
19070581-2	2008	Using this database, we show that although the CpG dinucleotide constitutes only 1% of the human genome, it accounts for 40%-70% of breakpoints at pro-B/pre-B stage translocation regions-specifically, those near the bcl-2, bcl-1, and E2A genes.	cytidylyl-3'-5'-guanosine	47-63	cyclin D1	Homo sapiens	223-228
18957421-4	2008	Forced depletion of CREB blocked Bt(2)cAMP-stimulated cyclin D1 expression and basal Wnt10b gene expression.	Cyclic AMP	38-42	cyclin D1	Homo sapiens	54-63
18957421-8	2008	What accounts for the differential regulation of cyclin D1 and Wnt10b genes by cAMP?	Cyclic AMP	79-83	cyclin D1	Homo sapiens	49-58
18957421-10	2008	CREB binding to the cyclin D1 promoter was detected in untreated cells and post-Bt(2)cAMP.	Cyclic AMP	85-89	cyclin D1	Homo sapiens	20-29
18794799-5	2008	Protac-B inhibited the proliferation of ERalpha-dependent breast cancer cells by inducing G(1) arrest, inhibition of retinoblastoma phosphorylation and decreasing expression of cyclin D1, progesterone receptors A and B.	protac-b	0-8	cyclin D1	Homo sapiens	177-186
18957421-13	2008	We conclude that cAMP stimulates phosphorylation and binding of CREB to the cyclin D1 gene promoter.	Cyclic AMP	17-21	cyclin D1	Homo sapiens	76-85
18798263-8	2008	Both carotenoids induced cell cycle arrest during G(1) phase by reducing the expression of cyclin D1, cyclin D2, CDK4 and CDK6, and inducing the expression of GADD45alpha, and induced apoptosis by reducing the expression of Bcl-2, XIAP, cIAP2 and survivin.	Carotenoids	5-16	cyclin D1	Homo sapiens	91-100
18286288-8	2008	Correlating with these findings, resveratrol induced more dramatic changes in the expression of Cyclin D1 compared to DMU-212.	Resveratrol	33-44	cyclin D1	Homo sapiens	96-105
19074853-5	2008	A lysine-less cyclin D1 species was resistant to these effects.	Lysine	2-8	cyclin D1	Homo sapiens	14-23
19020764-10	2008	However, in HL-60 cells, DPI irreversibly impaired cyclin D1 upregulation by serum stimulation and a much greater fraction of cells arrested in G0/G1 was observed in HL-60 cells than in HCT-116 cells at 24 h after brief DPI treatment.	diphenyleneiodonium	25-28	cyclin D1	Homo sapiens	51-60
19020764-11	2008	These results suggest that cyclin D1 is an important regulatory factor in the inhibition of cell cycle progression by DPI in HL-60 cells.	diphenyleneiodonium	118-121	cyclin D1	Homo sapiens	27-36
19046439-0	2008	Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1.	Metformin	21-30	cyclin D1	Homo sapiens	106-115
19046439-8	2008	As in previous studies, metformin treatment led to activation of (AMPK) and downregulation of cyclin D1.	Metformin	24-33	cyclin D1	Homo sapiens	94-103
19046439-13	2008	CONCLUSION: Cell cycle arrest in response to metformin requires CDK inhibitors in addition to AMPK activation and cyclin D1 downregulation.	Metformin	45-54	cyclin D1	Homo sapiens	114-123
19074853-13	2008	Increased UBE1L with reduced cyclin D1 and Ki-67 expression occurred in human lung cancer when a therapeutic bexarotene intratumoral level was achieved.	Bexarotene	109-119	cyclin D1	Homo sapiens	29-38
19074853-7	2008	Cycloheximide treatment augmented this cyclin D1 protein instability.	Cycloheximide	0-13	cyclin D1	Homo sapiens	39-48
19074853-11	2008	Treatment with the retinoid X receptor agonist bexarotene induced UBE1L and reduced cyclin D1 immunoblot expression.	Bexarotene	47-57	cyclin D1	Homo sapiens	84-93
19134409-5	2008	RESULTS: Compared with the control group, the expression of p-PKCalpha and ERK1/2, p-ERK1/2 protein increased, the expression of cyclinD1, P21(cip1) protein increased correspondingly (the A value % control was 2.10 +/- 0.29, 1.67 +/- 0.19, 2.20 +/- 0.27, 1.99 +/- 0.22 and 3.11 +/- 0.29 respectively; q value was 9.87, 7.06, 10.57, 11.10 and 20.33 respectively; all P &lt; 0.05) in PMA treated group, and cells proliferation [the percentage of cells in S phase was (30.3 +/- 2.4)%, A(490) value was 0.80 +/- 0.06] enhanced significantly compared with those [the percentage of cells in S phase was (13.9 +/- 2.6)%, A(490) value was 0.41 +/- 0.04] of the control group (q = 6.07, 12.63; all P &lt; 0.05).	Tetradecanoylphorbol Acetate	382-385	cyclin D1	Homo sapiens	129-137
19134409-6	2008	In PMA and PKCalpha-asODN treated group, the level of p-PKCalpha decreased, the expression of ERK1/2, p-ERK1/2 and the expression of cyclinD1, P21(cip1) decreased correspondingly (the A value % control was 1.23 +/- 0.19, 1.34 +/- 0.18, 1.52 +/- 0.20, 1.45 +/- 0.18 and 1.49 +/- 0.18 respectively; q value was 7.49, 3.58, 5.97, 6.06 and 15.65 respectively; all P &lt; 0.05), and cells proliferation reduced significantly [the percentage of cells in S phase was (21.2 +/- 2.8)%, A(490) value was 0.51 +/- 0.04; q = 6.07, 12.63; all P &lt; 0.05], as compared with those of the PMA treated group.	asodn	20-25	cyclin D1	Homo sapiens	133-141
19134409-6	2008	In PMA and PKCalpha-asODN treated group, the level of p-PKCalpha decreased, the expression of ERK1/2, p-ERK1/2 and the expression of cyclinD1, P21(cip1) decreased correspondingly (the A value % control was 1.23 +/- 0.19, 1.34 +/- 0.18, 1.52 +/- 0.20, 1.45 +/- 0.18 and 1.49 +/- 0.18 respectively; q value was 7.49, 3.58, 5.97, 6.06 and 15.65 respectively; all P &lt; 0.05), and cells proliferation reduced significantly [the percentage of cells in S phase was (21.2 +/- 2.8)%, A(490) value was 0.51 +/- 0.04; q = 6.07, 12.63; all P &lt; 0.05], as compared with those of the PMA treated group.	Tetradecanoylphorbol Acetate	3-6	cyclin D1	Homo sapiens	133-141
19134409-7	2008	In PMA and U0126 treated group, the level of p-PKCalpha had no significant change (A value was1.99 +/- 0.18, q = 0.94, P &gt; 0.05), but the levels of ERK1/2, p-ERK1/2 decreased, the expression of cyclinD1, P21(cip1) reduced (the A value % control was 0.95 +/- 0.21, 1.15 +/- 0.19, 1.37 +/- 0.15 and 1.96 +/- 0.21 respectively; q value was 7.79, 9.16, 6.92 and 11.16 respectively; all P &lt; 0.05), and cells proliferation reduced significantly [the percentage of cells in S phase was (22.0 +/- 3.2)%, A(490) value was 0.49 +/- 0.03; q = 5.51, 13.45; all P &lt; 0.05], as compared with those of the PMA treated group.	U 0126	11-16	cyclin D1	Homo sapiens	197-205
19134409-7	2008	In PMA and U0126 treated group, the level of p-PKCalpha had no significant change (A value was1.99 +/- 0.18, q = 0.94, P &gt; 0.05), but the levels of ERK1/2, p-ERK1/2 decreased, the expression of cyclinD1, P21(cip1) reduced (the A value % control was 0.95 +/- 0.21, 1.15 +/- 0.19, 1.37 +/- 0.15 and 1.96 +/- 0.21 respectively; q value was 7.79, 9.16, 6.92 and 11.16 respectively; all P &lt; 0.05), and cells proliferation reduced significantly [the percentage of cells in S phase was (22.0 +/- 3.2)%, A(490) value was 0.49 +/- 0.03; q = 5.51, 13.45; all P &lt; 0.05], as compared with those of the PMA treated group.	Tetradecanoylphorbol Acetate	3-6	cyclin D1	Homo sapiens	197-205
18806267-5	2008	HMW-HA binding to CD44 selectively inhibits the GTP loading of Rac and Rac-dependent signaling to the cyclin D1 gene, whereas LMW-HA binding to CD44 selectively stimulates ERK activation and ERK-dependent cyclin D1 gene expression.	Guanosine Triphosphate	48-51	cyclin D1	Homo sapiens	102-111
18806267-5	2008	HMW-HA binding to CD44 selectively inhibits the GTP loading of Rac and Rac-dependent signaling to the cyclin D1 gene, whereas LMW-HA binding to CD44 selectively stimulates ERK activation and ERK-dependent cyclin D1 gene expression.	lmw-ha	126-132	cyclin D1	Homo sapiens	205-214
19009649-6	2008	Stability of Cyclin D1 was studied by cycloheximide blockade experiments.	Cycloheximide	38-51	cyclin D1	Homo sapiens	13-22
19009649-12	2008	Abrogation of EGF-R signalling in IHH-Fos by treatment with AG1478, a specific EGF-R tyrosine kinase inhibitor, prevented the phosphorylation of GSK-3beta induced by serum stimulation and decreased Cyclin D1 stability in the nucleus.	RTKI cpd	60-66	cyclin D1	Homo sapiens	198-207
19189639-9	2008	CONCLUSION: PGZ down-regulates COX-2 and cyclin D1 and inhibits colon cancer proliferation and liver metastasis, making PPARgamma a candidate target for the treatment/prevention of colon cancer metastasis.	Pioglitazone	12-15	cyclin D1	Homo sapiens	41-50
19189664-5	2008	Berberine much greatly decreased G0/G1 phase-associated cyclin and cyclin-dependent kinase (cyclin D1, cyclin E, Cdk2, and Cdk4) expression, and increased apoptotic gene expression and activation of caspase-3 in SK-N-SH cells.	Berberine	0-9	cyclin D1	Homo sapiens	92-101
18949380-5	2008	In addition, TsA markedly down-regulated the expression of cyclin D1 and CDK4, up-regulated the expression of p21WAF1 and p53 and induced cell cycle arrest at the G1 phase in MCF10A-ras cells.	trichostatin A	13-16	cyclin D1	Homo sapiens	59-68
19111001-7	2008	Taken together, these results indicate that IQDMA causes significant induction of apoptosis in K562 cells via downregulation of EGFR, Src, Bcr-Abl, JAK2, and STAT5 signaling and modulation of p21, p27, cyclin D1, Mcl-1, Bcl-X(L), and VEGF proteins.	N'-(11H-indolo(3,2-c)quinolin-6-yl)-N,N-dimethylethane-1,2-diamine	44-49	cyclin D1	Homo sapiens	202-211
18799615-3	2008	Only in Ret/PTC1-positive TPC-1 cells did cAMP markedly inhibit the Raf/ERK cascade, leading to mTOR pathway inhibition, repression of cyclin D1 and p21 and p27 accumulation.	Cyclic AMP	42-46	cyclin D1	Homo sapiens	135-144
18554781-6	2008	When analyzing the expression of cell cycle-related proteins, we found that HS-1200 reduced the expression levels of cyclin D1, cyclin A, and Cdk2.	HS 1200	76-83	cyclin D1	Homo sapiens	117-126
18799615-6	2008	However, cAMP differentially inhibited the pRb-kinase activity and T172-phosphorylation of CDK4 complexed to cyclin D1 or cyclin D3, whereas CDK-activating kinase activity remained unaffected.	Cyclic AMP	9-13	cyclin D1	Homo sapiens	109-118
18638462-8	2008	Furthermore, IQDMA up-regulated Bax, and down-regulated Bcl-2, Bcl-X(L), cyclin D1, and vascular endothelial growth factor (VEGF) as followed by growth arrest of HL-60 cells, but the expression of survivin did not change in the presence of IQDMA.	N'-(11H-indolo(3,2-c)quinolin-6-yl)-N,N-dimethylethane-1,2-diamine	13-18	cyclin D1	Homo sapiens	73-82
18638462-9	2008	Taken together, these results indicate that IQDMA causes significant induction of apoptosis in HL-60 cells via down-regulation of Src, IL-6, and STAT5 signaling and modulation of Bcl-2 family, cyclin D1 and VEGF proteins.	N'-(11H-indolo(3,2-c)quinolin-6-yl)-N,N-dimethylethane-1,2-diamine	44-49	cyclin D1	Homo sapiens	193-202
18842998-1	2008	This study explores the relationship between genetic polymorphisms of p53, p21, and CCND1, and the susceptibility of chromosomal damage induced by vinyl chloride monomer (CH(2)=CHCl, VCM).	Vinyl Chloride	147-161	cyclin D1	Homo sapiens	84-89
18640142-1	2008	INTRODUCTION: Polymorphisms in p53, p21 and CCND1 could regulate the progression of the cell cycle and might increase the susceptibility to inorganic arsenic-related cancer risk.	Arsenic	150-157	cyclin D1	Homo sapiens	44-49
18836303-7	2008	After treatment with FLX, A549 and HT29 cells demonstrated concentration-dependent decrease in the expression of c-fos, c-jun, cyclin A, cyclin D1, and increased expression of p21(waf1) and p53 genes, which resulted in slowing of the cell cycle progression.	Fluoxetine	21-24	cyclin D1	Homo sapiens	137-146
18818515-6	2008	Cyclin D1 proteolysis requires phosphorylation by GSK3beta at Thr-286; additional work recently established that p286-D1 is a substrate for the SCF(Fbx4/alphaB-crystallin) E3 ligase.	Threonine	62-65	cyclin D1	Homo sapiens	0-9
18703151-0	2008	Downregulation of cyclin D1-CDK4 protein in human embryonic lung fibroblasts (HELF) induced by silica is mediated through the ERK and JNK pathway.	Silicon Dioxide	95-101	cyclin D1	Homo sapiens	18-27
18703151-4	2008	We found that exposure of human embryonic lung fibroblasts (HELF) to crystalline silica for 2h decreased cyclin D1 and cyclin-dependent kinase 4 (CDK4) expression levels.	Silicon Dioxide	81-87	cyclin D1	Homo sapiens	105-114
18703151-4	2008	We found that exposure of human embryonic lung fibroblasts (HELF) to crystalline silica for 2h decreased cyclin D1 and cyclin-dependent kinase 4 (CDK4) expression levels.	Deuterium	92-94	cyclin D1	Homo sapiens	105-114
18703151-5	2008	Extracellular signal-regulated protein kinase (ERKs), c-Jun NH2-terminal amino kinase (JNKs), and p38 kinase, as well as their downstream transcription factor, AP-1, had different effects on the regulation of expression levels of cyclin D1 and CDK4 alterations induced by silica.	Silicon Dioxide	272-278	cyclin D1	Homo sapiens	230-239
18703151-9	2008	AG126 (a chemical inhibitor of the ERK signaling pathway) and the dominant negative mutant of ERK2 (a molecular inhibitor of ERK2) prevented decreases in cyclin D1 and CDK4 expression levels.	AG 127	0-5	cyclin D1	Homo sapiens	154-163
18703151-10	2008	A chemical inhibitor of JNK, SP600125, prevented the decreased expression of both cyclin D1 and CDK4, whereas SB203580, a chemical inhibitor of p38, did not.	pyrazolanthrone	29-37	cyclin D1	Homo sapiens	82-91
18703151-12	2008	These results demonstrate that ERKs and JNKs are responsible for the decrease of cyclin D1 and CDK4 expression levels in HELF induced by silica.	Silicon Dioxide	137-143	cyclin D1	Homo sapiens	81-90
18925698-4	2008	Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue by antibody p27 and cyclin D1.	Formaldehyde	38-46	cyclin D1	Homo sapiens	99-108
18813800-7	2008	A significant additive effect in reducing cyclin D1 and bcl-2 expression was found when gamma-tocotrienol was added with either EGCG or resveratrol.	plastochromanol 8	88-105	cyclin D1	Homo sapiens	42-51
18567737-4	2008	Resveratrol significantly blocked PDGF-stimulated c-Src and Akt kinase activation, resulting in reduced cyclin D1 expression and attenuated pRb phosphorylation and cyclin-dependent kinase-2 (CDK2) activity.	Resveratrol	0-11	cyclin D1	Homo sapiens	104-113
18813800-7	2008	A significant additive effect in reducing cyclin D1 and bcl-2 expression was found when gamma-tocotrienol was added with either EGCG or resveratrol.	epigallocatechin gallate	128-132	cyclin D1	Homo sapiens	42-51
18813800-7	2008	A significant additive effect in reducing cyclin D1 and bcl-2 expression was found when gamma-tocotrienol was added with either EGCG or resveratrol.	Resveratrol	136-147	cyclin D1	Homo sapiens	42-51
18815740-10	2008	The expression of the oestrogen-target genes of pS2, progesterone receptor, and cyclin D1 correlates with the growth of E-dependent tumours and has been consistently observed to be induced in response to treatment with dietary genistein.	Genistein	227-236	cyclin D1	Homo sapiens	80-89
18929848-15	2008	FK506 induced G0/G1 phase cell cycle arrest via expression of CDK4 and cyclin D1.	Tacrolimus	0-5	cyclin D1	Homo sapiens	71-80
18710949-12	2008	Thus, while PKB-dependent p27 phosphorylation appears to increase cyclin D1-Cdk4-p27 assembly or stabilize these complexes in vitro, cyclin D1-Cdk4-p27 activation requires the tyrosine phosphorylation of p27.	Tyrosine	176-184	cyclin D1	Homo sapiens	133-142
18650423-5	2008	Of several kinases examined, inhibition of IkappaB kinase alpha blocked STG28-mediated cytoplasmic sequestration and degradation of cyclin D1.	5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione	72-77	cyclin D1	Homo sapiens	132-141
18650423-0	2008	A novel mechanism by which thiazolidinediones facilitate the proteasomal degradation of cyclin D1 in cancer cells.	Thiazolidinediones	27-45	cyclin D1	Homo sapiens	88-97
18650423-10	2008	Moreover, we obtained evidence that this beta-TrCP-dependent degradation takes part in controlling cyclin D1 turnover when cancer cells undergo glucose starvation, which endows physiological relevance to this novel mechanism.	Glucose	144-151	cyclin D1	Homo sapiens	99-108
18650423-1	2008	This study identifies a novel mechanism by which thiazolidinediones mediate cyclin D1 repression in prostate cancer cells.	Thiazolidinediones	49-67	cyclin D1	Homo sapiens	76-85
18713830-5	2008	VRK1 specifically enhances activity of the cAMP-response element (CRE) in the CCND1 promoter by facilitating the recruitment of phospho-CREB to this locus.	Cyclic AMP	43-47	cyclin D1	Homo sapiens	78-83
18650423-2	2008	Based on the finding that the thiazolidinedione family of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists mediated PPARgamma-independent cyclin D1 degradation, we developed a novel PPARgamma-inactive troglitazone derivative, STG28, with high potency in cyclin D1 ablation.	2,4-thiazolidinedione	30-47	cyclin D1	Homo sapiens	159-168
18650423-2	2008	Based on the finding that the thiazolidinedione family of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists mediated PPARgamma-independent cyclin D1 degradation, we developed a novel PPARgamma-inactive troglitazone derivative, STG28, with high potency in cyclin D1 ablation.	2,4-thiazolidinedione	30-47	cyclin D1	Homo sapiens	275-284
18650423-2	2008	Based on the finding that the thiazolidinedione family of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists mediated PPARgamma-independent cyclin D1 degradation, we developed a novel PPARgamma-inactive troglitazone derivative, STG28, with high potency in cyclin D1 ablation.	Troglitazone	222-234	cyclin D1	Homo sapiens	159-168
18650423-2	2008	Based on the finding that the thiazolidinedione family of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists mediated PPARgamma-independent cyclin D1 degradation, we developed a novel PPARgamma-inactive troglitazone derivative, STG28, with high potency in cyclin D1 ablation.	Troglitazone	222-234	cyclin D1	Homo sapiens	275-284
18769147-7	2008	Notably, rapamycin downregulated GSK-3beta Ser9 phosphorylation with concurrent nuclear export of cyclin D1 only in MCL cells in which GSK-3beta is under the control of mTOR.	Sirolimus	9-18	cyclin D1	Homo sapiens	98-107
18673534-9	2008	However, overexpression of AR enhanced the DHT-stimulated expression of MAK, BRCA1, AIB1 and CBP and reduced the level of expression of beta-catenin, cyclinD1 and gelsolin.	Dihydrotestosterone	43-46	cyclin D1	Homo sapiens	150-158
18764945-2	2008	Following the G1/S transition, cyclin D1 activation is antagonized by GSK3beta-dependent threonine-286 (Thr-286) phosphorylation, triggering nuclear export and subsequent cytoplasmic degradation mediated by the SCFFbx4-alphaBcrystallin E3 ubiquitin ligase.	Threonine	89-98	cyclin D1	Homo sapiens	31-40
18764945-2	2008	Following the G1/S transition, cyclin D1 activation is antagonized by GSK3beta-dependent threonine-286 (Thr-286) phosphorylation, triggering nuclear export and subsequent cytoplasmic degradation mediated by the SCFFbx4-alphaBcrystallin E3 ubiquitin ligase.	Threonine	104-107	cyclin D1	Homo sapiens	31-40
19035289-0	2008	Growth inhibition of human MDA-mB-231 breast cancer cells by delta-tocotrienol is associated with loss of cyclin D1/CDK4 expression and accompanying changes in the state of phosphorylation of the retinoblastoma tumor suppressor gene product.	tocotrienol, delta	61-78	cyclin D1	Homo sapiens	106-115
19035289-5	2008	The site-specific inhibition of the phosphorylation of Rb by delta-tocotrienol was tightly associated with a marked reduction in the expression of cyclin D1 and its regulatory partner cyclin-dependant kinase 4 (CDK4), which is responsible for the phosphorylation of Rb at Ser780, Ser795, Ser 807/811 and Thr826.	tocotrienol, delta	61-78	cyclin D1	Homo sapiens	147-156
19035289-8	2008	To the best of our knowledge, this study was the first to reveal that the target of cell proliferative inhibitory action of delta-tocotrienol in a model estrogen receptor-negative human breast cancer cell line MDA-MB-231 is mediated by the loss of cyclin D1 and associated suppression of site-specific Rb phosphorylation, suggesting its future development and use as an anticancer agent.	tocotrienol, delta	124-141	cyclin D1	Homo sapiens	248-257
18640102-8	2008	Our findings also demonstrated that 12(S)-HETE exerts these effects through enantiospecific interactions with a cellular element, probably a plasma membrane receptor coupling to a pertussis toxin-sensitive protein G. Moreover, these elements may be involved in the activation of mitogen-activated protein kinase pathways which induce the enhancement of cyclin D(1) levels.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid	36-46	cyclin D1	Homo sapiens	353-364
18616527-0	2008	Reactive oxygen species-mediated cyclin D1 degradation mediates tumor growth retardation in hypoxia, independently of p21cip1 and hypoxia-inducible factor.	Reactive Oxygen Species	0-23	cyclin D1	Homo sapiens	33-42
18616527-7	2008	Moreover, antioxidants prevented the hypoxic degradation of cyclin D1 and hydrogen peroxide destabilized cyclin D1 in normoxia.	Hydrogen Peroxide	74-91	cyclin D1	Homo sapiens	105-114
18616527-9	2008	Given the results, we here propose that reactive oxygen species-mediated cyclin D1 degradation contributes to tumor growth retardation in hypoxic environments.	Reactive Oxygen Species	40-63	cyclin D1	Homo sapiens	73-82
18652887-3	2008	DNA flow cytometric analysis indicated that PG induced a G2 phase arrest of the cell cycle in Calu-6 cells at 72 h. PG down-regulated the expression of CDKI (p27), CDK2, CDK4 and CDK6 as well as cyclin D1, and increased cyclin A and cyclin B1 proteins.	Pyrogallol	44-46	cyclin D1	Homo sapiens	195-204
18662759-6	2008	Thus, these results indicated that TOCP might induce potential neurodevelopmental toxicity, and a possible mechanism of this toxicity might be the disturbance of cell proliferation by disrupting cell cycle regulatory proteins cyclin D1 and p21 expression.	tri-o-cresyl phosphate	35-39	cyclin D1	Homo sapiens	226-235
18650093-1	2008	We present the design, synthesis and biological activity of a library of substituted (biphenylcarbonyl)-tryptamine and (biphenylcarbonyl)-tetrahydro-beta-carboline compounds related to the natural product fascaplysin, as novel inhibitors of CDK4/cyclin D1.	(biphenylcarbonyl)-tryptamine	85-114	cyclin D1	Homo sapiens	246-255
18650093-1	2008	We present the design, synthesis and biological activity of a library of substituted (biphenylcarbonyl)-tryptamine and (biphenylcarbonyl)-tetrahydro-beta-carboline compounds related to the natural product fascaplysin, as novel inhibitors of CDK4/cyclin D1.	(biphenylcarbonyl)-tetrahydro-beta-carboline	119-163	cyclin D1	Homo sapiens	246-255
18619950-11	2008	These results suggested Andro can inhibit Lovo cell growth by G1-S phase arrest, and was exerted by inducing the expression of p53, p21 and p16 that, in turn, repressed the activity of Cyclin D1/Cdk4 and/or Cyclin A/Cdk2, as well as Rb phosphorylation.	Rubidium	233-235	cyclin D1	Homo sapiens	185-194
18573488-8	2008	Furthermore, fluoxetine-induced activation of both the cAMP-response element-binding (CREB) protein and extracellular signal-regulated protein kinases (ERK1/2), which was abolished by the selective inhibitor of MAP kinase kinase (MEK) 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene (U0126), and increased cyclin D1 expression.	Fluoxetine	13-23	cyclin D1	Homo sapiens	318-327
18573488-8	2008	Furthermore, fluoxetine-induced activation of both the cAMP-response element-binding (CREB) protein and extracellular signal-regulated protein kinases (ERK1/2), which was abolished by the selective inhibitor of MAP kinase kinase (MEK) 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene (U0126), and increased cyclin D1 expression.	Cyclic AMP	55-59	cyclin D1	Homo sapiens	318-327
18573488-8	2008	Furthermore, fluoxetine-induced activation of both the cAMP-response element-binding (CREB) protein and extracellular signal-regulated protein kinases (ERK1/2), which was abolished by the selective inhibitor of MAP kinase kinase (MEK) 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene (U0126), and increased cyclin D1 expression.	U 0126	235-294	cyclin D1	Homo sapiens	318-327
18621911-6	2008	Exogenous PA caused cellular proliferation and revitalized cyclin D1 expression by 5-HT of the 1-butanol-treated cells.	Phosphatidic Acids	10-12	cyclin D1	Homo sapiens	59-68
18621911-6	2008	Exogenous PA caused cellular proliferation and revitalized cyclin D1 expression by 5-HT of the 1-butanol-treated cells.	1-Butanol	95-104	cyclin D1	Homo sapiens	59-68
18695876-4	2008	Momilactone B, extracted from Korean rice hulls, suppressed hypoxia-induced increases in phospho-STAT5, STAT5b, cyclin D1, and cdk4 protein levels in human breast cancer cells.	momilactone	0-11	cyclin D1	Homo sapiens	112-121
18695886-0	2008	BRCA1 overexpression sensitizes cancer cells to lovastatin via regulation of cyclin D1-CDK4-p21WAF1/CIP1 pathway: analyses using a breast cancer cell line and tumoral xenograft model.	Lovastatin	48-58	cyclin D1	Homo sapiens	77-86
18695886-7	2008	Additionally, the mRNA and protein expression of cyclin D1, cyclin-dependent kinase 4 (CDK4) and retinoblastoma protein (pRb), was further down-regulated under exposure to lovastatin in condition of BRCA1 overexpression, but the expression of p21WAF1/CIP1, a cyclin-dependent kinase inhibitor (CDKI), was further up-regulated, both in vitro and in vivo detected with quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot analysis.	Lovastatin	172-182	cyclin D1	Homo sapiens	49-58
18695886-9	2008	Our results suggest that BRCA1 overexpression sensitizes cancer cells to lovastatin via regulation of cyclin D1-CDK4-p21WAF1/CIP1 pathway, which will provide an innovative experimental framework to study control of breast cancer cell proliferation.	Lovastatin	73-83	cyclin D1	Homo sapiens	102-111
18594209-6	2008	Importantly, 17-AAG cooperates with rapamycin to block the phosphorylation of the mammalian target of rapamycin at Ser2448, as well as its downstream effectors ribosomal p70 S6 kinase and eukaryotic initiation factor 4E binding protein 1, which is accompanied by a substantial reduction in cyclins D1 and E.	tanespimycin	13-19	cyclin D1	Homo sapiens	290-306
18519516-5	2008	RESULTS: Dasatinib induced G(1) phase arrest in all cell lines and this was associated with a decline in cyclin D1 levels.	Dasatinib	9-18	cyclin D1	Homo sapiens	105-114
18474441-6	2008	Moreover, troglitazone treatment, applied in a dose-dependent manner, caused a marked decrease in pRb, cyclin D1, cyclin D2, cyclin D3, Cdk2, Cdk4 and Cdk6 expression as well as a significant increase in p21 and p27 expression.	Troglitazone	10-22	cyclin D1	Homo sapiens	103-112
18665077-4	2008	METHODS: Parental cells, cells overexpressing FGFR1-III isoforms, and cells harboring a tetracycline-inducible cyclin D1 antisense expression vector system were used as model systems.	Tetracycline	88-100	cyclin D1	Homo sapiens	111-120
18556204-3	2008	4-HPR, a synthetic retinoid that down-modulates Cyclin D1, has shown promise in treating various tumors including RTs.	Retinoids	19-27	cyclin D1	Homo sapiens	48-57
18448488-9	2008	We conclude that through nAChR and beta-adrenoceptors, nicotine activates ERK1/2 and Stat3 signaling pathways, leading to Cyclin D1 expression and cell proliferation.	Nicotine	55-63	cyclin D1	Homo sapiens	122-131
18097517-0	2008	Dexamethasone suppresses DU145 cell proliferation and cell cycle through inhibition of the extracellular signal-regulated kinase 1/2 pathway and cyclin D1 expression.	Dexamethasone	0-13	cyclin D1	Homo sapiens	145-154
18609681-10	2008	Moreover, lithium slightly elevated cyclin D1 protein expression, whereas lowered the cyclin B1 expression after 24 h lithium exposure and no obvious change was observed for cdc2 protein.	Lithium	10-17	cyclin D1	Homo sapiens	36-45
18097517-3	2008	Western blot analysis was carried out to evaluate the effects of dexamethasone on phosphorylation of extracellular signal-regulated kinase (ERK)1/2 and expression of cyclin D1 in DU145 cells with or without glucocorticoid receptor (GR) antagonist RU486.	Mifepristone	247-252	cyclin D1	Homo sapiens	166-175
18097517-6	2008	Western blot analysis showed a dramatic reduction of ERK1/2 activity and cyclin D1 expression in dexamethasone-treated cells.	Dexamethasone	97-110	cyclin D1	Homo sapiens	73-82
18097517-8	2008	Additionally, the effects of dexamethasone in inhibiting cyclin D1 expression were altered by GR blockade.	Dexamethasone	29-42	cyclin D1	Homo sapiens	57-66
18097517-9	2008	CONCLUSION: Dexamethasone suppresses DU145 cell proliferation and cell cycle, and the underlying mechanisms are through the inhibition of phosphorylation of ERK1/2 and cyclin D1 expression.	Dexamethasone	12-25	cyclin D1	Homo sapiens	168-177
18437054-4	2008	Activation of GSK3beta via AKT inhibitoion induced by tetrandrine resulted in enhanced phosphorylation and proteolysis of cyclin D(1), activation of caspase 3 and subsequent cleavage of PARP.	tetrandrine	54-65	cyclin D1	Homo sapiens	122-133
18515102-3	2008	Previously we demonstrated that 4-HPR, a synthetic retinoid that targets Cyclin D1, is a potential chemotherapeutic agent for RT.	Retinoids	51-59	cyclin D1	Homo sapiens	73-82
18593936-5	2008	Moreover, using RNA interference with small inhibitory RNAs for Sp1, Sp3, and Sp4, we observed that curcumin-dependent inhibition of nuclear factor kappaB (NF-kappaB)-dependent genes, such as bcl-2, survivin, and cyclin D1, was also due, in part, to loss of Sp proteins.	Curcumin	100-108	cyclin D1	Homo sapiens	213-222
18356276-10	2008	The progrowth signaling via AKT-mammalian target rapamycin-p70(S6K) and cyclin D1/cyclin-dependent kinase were inhibited, and proapoptotic activity of Bcl-2-associated death promoter was increased by LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-208	cyclin D1	Homo sapiens	72-81
18386790-4	2008	Curcumin is incorporated into H-RS cells and acts inhibiting both NF-kappaB and STAT3 activation, leading to a decreased expression of proteins involved in cell proliferation and apoptosis, e.g. Bcl-2, Bcl-xL, cFLIP, XIAP, c-IAP1, survivin, c-myc and cyclin D1.	Curcumin	0-8	cyclin D1	Homo sapiens	251-260
18507431-3	2008	We show that resveratrol induces apoptosis in Jeko-1 cells and modulates several key molecules, including cyclin D1 (CCND1), p53 (TP53), p21 (CDKN1A), BCL2, BAX, Bcl XL (BCL2L1), caspase 9 (CASP9) and p27 (CDKN1B).	Resveratrol	13-24	cyclin D1	Homo sapiens	106-115
18507431-3	2008	We show that resveratrol induces apoptosis in Jeko-1 cells and modulates several key molecules, including cyclin D1 (CCND1), p53 (TP53), p21 (CDKN1A), BCL2, BAX, Bcl XL (BCL2L1), caspase 9 (CASP9) and p27 (CDKN1B).	Resveratrol	13-24	cyclin D1	Homo sapiens	117-122
18575719-5	2008	Cyclin D1 and survivin were expressed at a very high rate and almost to the same extent in LPTC and PTM, both in tumoral mass and in nodal metastases.	lptc	91-95	cyclin D1	Homo sapiens	0-9
18839518-0	2008	[Cell cycle alterations of human embryo lung fibroblasts induced by benzo(a)pyrene is positively regulated by cyclin D1 and CDK4].	Benzo(a)pyrene	68-82	cyclin D1	Homo sapiens	110-119
18839518-1	2008	OBJECTIVE: To study the effects of benzo(a)pyrene (B(a)P) on the cell cycle distributions and expression of cell cycle regulated protein cyclin D1 and CDK4 in human embryo lung fibroblasts (HELF), and to investigate the relationship between the expression of both cyclin D1 and CDK4 proteins and the cell cycle alterations.	Benzo(a)pyrene	35-49	cyclin D1	Homo sapiens	137-146
19080374-4	2008	RESULTS: The exposure of HELF to crystalline quartz for 2 hours could cause the decrease of cyclin D1 and cyclin dependent kinase 4 (CDK4) protein expression level, (7.91 +/- 0.29) x 10(3) and (5.17 +/- 0.28) x 10(4) respectively, which was lower than that of the HELF group (P &lt; 0.05).	helf	25-29	cyclin D1	Homo sapiens	92-101
19080374-5	2008	AG126 (chemical inhibitor of the extracellular signal regulated protein kinase (ERK) signaling pathway) and the dominant negative mutant of ERK2 (molecular inhibitor of ERK2), prevented the decrease of cyclin D1 and CDK4 protein expression level.	AG 127	0-5	cyclin D1	Homo sapiens	202-211
19080374-6	2008	The chemical inhibitor of c-Jun NH2-terminal amino kinase (JNK), SP600125, could prevent both cyclin D1 and CDK4 protein expression level decrease.	pyrazolanthrone	65-73	cyclin D1	Homo sapiens	94-103
18321638-3	2008	Thio-Cl-IB-MECA induced arrest of cell cycle progression in G0/G1 phase at lower concentrations (up to 20 microM) and apoptotic cell death at a higher concentration (80 microM), which were manifested by down-regulation of cyclin D1, c-myc, and CDK4, activation of caspase-3 and -9, and cleavage of poly(ADP-ribose) polymerase (PARP).	thio-Cl-IB-MECA	0-15	cyclin D1	Homo sapiens	222-231
18559511-4	2008	An increase in PP2A activity or treatment with rapamycin leads to cytosolic retention of GLI3 and, consequently, reduced transcription of the GLI3 target gene and cell cycle regulator, cyclin D1.	Sirolimus	47-56	cyclin D1	Homo sapiens	185-194
18212742-0	2008	The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.	Metformin	22-31	cyclin D1	Homo sapiens	104-113
18212742-10	2008	Similar, to the in vitro study, metformin led to a strong reduction of cyclin D1 protein level in tumors providing evidence for a mechanism that may contribute to the antineoplastic effects of metformin suggested by recent epidemiological studies.	Metformin	32-41	cyclin D1	Homo sapiens	71-80
18212742-10	2008	Similar, to the in vitro study, metformin led to a strong reduction of cyclin D1 protein level in tumors providing evidence for a mechanism that may contribute to the antineoplastic effects of metformin suggested by recent epidemiological studies.	Metformin	193-202	cyclin D1	Homo sapiens	71-80
18430409-3	2008	Acetyl-11-keto-beta-boswellic acid (AKBA), a compound isolated from the gum-resin of Boswellia carterii, caused G1-phase cell cycle arrest with an induction of p21(WAF1/CIP1), and a reduction of cyclin D1 as well in prostate cancer cells.	acetyl-11-ketoboswellic acid	36-40	cyclin D1	Homo sapiens	195-204
18598164-4	2008	Of the G(1) phase cycle-related proteins examined, the expressions of cyclin-dependent kinase (CDK) 2, CDK4, and CDK6 and of cyclin D(1), D(2), and D(3) were found to be markedly reduced by EAPP, whereas cyclin E was unaffected.	eapp	190-194	cyclin D1	Homo sapiens	125-136
18593939-8	2008	Berberine also suppressed the expression of NF-kappaB-regulated gene products involved in antiapoptosis (Bcl-xL, Survivin, IAP1, IAP2, and cFLIP), proliferation (cyclin D1), inflammation (cyclooxygenase-2), and invasion (matrix metalloproteinase-9).	Berberine	0-9	cyclin D1	Homo sapiens	162-171
18402936-5	2008	Furthermore, in terms of the effects of YSK2821 on cell cycle-related proteins, YSK2821 enhanced the expression of the cyclin-dependent protein kinase (CDK) inhibitor p27 and down-regulated CDK2 and cyclin E expression, but did not affect CDK4 and cyclin D1 expression.	YSK 2821	80-87	cyclin D1	Homo sapiens	248-257
18326051-9	2008	The triple combination of erlotinib, STAT3 decoy, and gossypol further enhanced cell growth inhibition and apoptosis in vitro, and it down-regulated signaling molecules further downstream of the EGFR-STAT3 signaling pathway, such as cyclin D1.	Erlotinib Hydrochloride	26-35	cyclin D1	Homo sapiens	233-242
18495890-2	2008	Using the camptothecin-induced DNA damage model in neurons, we previously showed that cyclin D1-associated cell cycle cyclin-dependent kinases (Cdks) (Cdk4/6) and p53 activation are two major events leading to activation of the mitochondrial apoptotic pathway.	Camptothecin	10-22	cyclin D1	Homo sapiens	86-95
18430372-0	2008	Berberine inhibits cyclin D1 expression via suppressed binding of AP-1 transcription factors to CCND1 AP-1 motif.	Berberine	0-9	cyclin D1	Homo sapiens	19-28
18280643-4	2008	In patients treated with tamoxifen, a trend to significant relation between poor outcome and cyclin D1 mRNA was found.	Tamoxifen	25-34	cyclin D1	Homo sapiens	93-102
18483258-0	2008	UVA-induced cell cycle progression is mediated by a disintegrin and metalloprotease/epidermal growth factor receptor/AKT/Cyclin D1 pathways in keratinocytes.	uva	0-3	cyclin D1	Homo sapiens	121-130
18483258-4	2008	UVA irradiation also induced AKT activation; when cells were incubated with phosphatidylinositol-3-OH kinase/AKT inhibitor or infected with dominant-negative AKT, cyclin D1 up-regulation, cell cycle progression, and proliferation were inhibited, suggesting that AKT activation is required for UVA-induced cell cycle progression.	Phosphatidylinositols	76-96	cyclin D1	Homo sapiens	163-172
18430372-0	2008	Berberine inhibits cyclin D1 expression via suppressed binding of AP-1 transcription factors to CCND1 AP-1 motif.	Berberine	0-9	cyclin D1	Homo sapiens	96-101
18430372-10	2008	Berberine could inhibit the expression of cyclin D1 in PG cells.	Berberine	0-9	cyclin D1	Homo sapiens	42-51
18430372-12	2008	Berberine suppressed the expression of c-Jun and decreased the binding of transcription factors to the CCND1 AP-1 motif.	Berberine	0-9	cyclin D1	Homo sapiens	103-108
18430372-13	2008	CONCLUSION: Berberine suppresses the activity of the AP-1 signaling pathway and decreases the binding of transcription factors to the CCND1 AP-1 motif.	Berberine	12-21	cyclin D1	Homo sapiens	134-139
18430372-14	2008	This is one of the important mechanisms behind the antitumoral effects of berberine as a regulator of cyclin D1.	Berberine	74-83	cyclin D1	Homo sapiens	102-111
18425329-3	2008	Estradiol induces cyclin D1 and CDK1 proteins in Ki-67 positive proliferating cells, whereas survivin is up-regulated in both Ki-67 positive proliferative outer layer of cells and around the necrotic zone in non-proliferating cells.	Estradiol	0-9	cyclin D1	Homo sapiens	18-27
17638069-4	2008	In response to OPDA treatment, the human breast cancer cell lines exhibit a progressive decline in cyclin D1 expression, which is tightly associated with the accumulation of hypophosphorylated form of the retinoblastoma protein (Rb) and G1 arrest.	12-oxophytodienoic acid	15-19	cyclin D1	Homo sapiens	99-108
17638069-5	2008	The decrease in cyclin D1 protein expression accompanies a dramatic decline in nuclear but not membranous beta-catenin expression and activation of glycogen synthase kinase-3-beta (GSK3beta) caused by inhibition of its serine-9 phosphorylation.	Serine	219-225	cyclin D1	Homo sapiens	16-25
17638069-6	2008	The proteasome inhibitor MG132 blocks OPDA-mediated decrease in cyclin D1.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	25-30	cyclin D1	Homo sapiens	64-73
17638069-6	2008	The proteasome inhibitor MG132 blocks OPDA-mediated decrease in cyclin D1.	12-oxophytodienoic acid	38-42	cyclin D1	Homo sapiens	64-73
17638069-7	2008	In addition, the overexpression of T286A, a cyclin D1 mutant which is refractory to phosphorylation by GSK3beta and proteosomal degradation, is resistant to OPDA-mediated Rb dephosphorylation as well as G(1) cell cycle arrest.	12-oxophytodienoic acid	157-161	cyclin D1	Homo sapiens	44-53
17638069-8	2008	Thus, our results demonstrate that degradation of cyclin D1 protein is a key event in OPDA induced growth inhibition in breast cancer cells.	12-oxophytodienoic acid	86-90	cyclin D1	Homo sapiens	50-59
18508473-9	2008	Similarly, treatment with PD98059 partially diminished the apelin-13-induced expression of cyclin D1 and vascular smooth muscle cell proliferation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	26-33	cyclin D1	Homo sapiens	91-100
18393977-3	2008	The aim was to investigate gene copy numbers of CCND1 and EMSY and to determine if CCND1 amplification is associated with reduced survival of tamoxifen-treated breast cancer patients.	Tamoxifen	142-151	cyclin D1	Homo sapiens	83-88
18393977-10	2008	However, as &gt;70% of EMSY amplifications were CCND1 amplified, EMSY may not have any additional effect on survival of ER+ breast cancer.	Aminoglutethimide	9-15	cyclin D1	Homo sapiens	48-53
17638069-0	2008	A plant oxylipin, 12-oxo-phytodienoic acid, inhibits proliferation of human breast cancer cells by targeting cyclin D1.	12-oxophytodienoic acid	18-42	cyclin D1	Homo sapiens	109-118
18425329-5	2008	Consistent with its antiproliferative effect, we observed that OH-Tam induces an important decrease in the proportion of proliferating cells, positive for Ki-67, cyclin D1 and CDK1.	oh-tam	63-69	cyclin D1	Homo sapiens	162-171
17949810-8	2008	Tyrosine phosphorylation of beta-catenin was associated with its nuclear localization and enhanced transcription of target genes c-myc and cyclin D1.	Tyrosine	0-8	cyclin D1	Homo sapiens	139-148
18424709-4	2008	TSA treatment inhibited the GM-CSF-dependent proliferation of macrophages by interfering with c-myc and cyclin D1 expression.	trichostatin A	0-3	cyclin D1	Homo sapiens	104-113
18431519-0	2008	Identification of kinetin riboside as a repressor of CCND1 and CCND2 with preclinical antimyeloma activity.	kinetin riboside	18-34	cyclin D1	Homo sapiens	53-58
18431519-6	2008	Mechanistically, kinetin riboside upregulated expression of transcription repressor isoforms of cAMP-response element modulator (CREM) and blocked both trans-activation of CCND2 by various myeloma oncogenes and cis-activation of translocated CCND1, suggesting induction of an overriding repressor activity that blocks multiple oncogenic pathways targeting cyclin D genes.	riboside	25-33	cyclin D1	Homo sapiens	242-247
18347178-1	2008	PURPOSE: The objective of our study was to determine the clinical relevance of cyclin D1 expression in hormone receptor-positive breast cancer patients who were treated with tamoxifen-based therapy.	Tamoxifen	174-183	cyclin D1	Homo sapiens	79-88
18245776-7	2008	Promoter analysis and EMSA revealed that copper stimulates the Atox1 binding to a previously undescribed cis element in the cyclin D1 promoter.	Copper	41-47	cyclin D1	Homo sapiens	124-133
18228003-7	2008	Tunicamycin induced a rapid decline of cyclin D1 and cyclin A expression and an early increase of glucose-related protein (GRP) 78 and growth arrest and DNA damage-inducible transcription factor (GADD) 153 levels.	Tunicamycin	0-11	cyclin D1	Homo sapiens	39-48
18228003-13	2008	The increased association of p27(Kip1) with cyclin D1/Cdk4 may also contribute to tunicamycin-induced cell-cycle arrest.	Tunicamycin	82-93	cyclin D1	Homo sapiens	44-53
18187174-8	2008	In addition, the downstream targets of p27, including CDK4, cyclin D1 and phosphorylated-Rb proteins, increased in 1 microM tt-DDE-treated cells and these changes were prevented by NAC co-treatment.	tt-dde	124-130	cyclin D1	Homo sapiens	60-69
18187174-8	2008	In addition, the downstream targets of p27, including CDK4, cyclin D1 and phosphorylated-Rb proteins, increased in 1 microM tt-DDE-treated cells and these changes were prevented by NAC co-treatment.	Acetylcysteine	181-184	cyclin D1	Homo sapiens	60-69
18187174-9	2008	Therefore, these results suggest that tt-DDE increased cell proliferation via inhibition of p27 expression, increase in CDK4/cyclin D1 protein accumulation and enhancement of Rb phosphorylation.	tt-dde	38-44	cyclin D1	Homo sapiens	125-134
18343280-7	2008	Mechanistically, temsirolimus inhibited mTOR, as evidenced by inhibition of ribosomal S6 phosphorylation, and induced cell-cycle arrest in the G(0)/G(1) phase and a decrease in p21 expression without altering p27 or cyclin D1 levels.	temsirolimus	17-29	cyclin D1	Homo sapiens	216-225
18166465-5	2008	2+SAHA treatment effectively down-regulated cyclin D1 and cdk4, and up-regulated pro-differentiation markers cytokeratins 8/18 and pro-apoptotic Bad and Bax.	Vorinostat	2-6	cyclin D1	Homo sapiens	44-53
18347178-9	2008	CONCLUSION: Cyclin D1 expression is an independent poor prognostic factor in women with early-stage, hormone receptor-positive breast cancer who received adjuvant tamoxifen-based therapy.	Tamoxifen	163-172	cyclin D1	Homo sapiens	12-21
18261747-0	2008	Rottlerin inhibits the nuclear factor kappaB/cyclin-D1 cascade in MCF-7 breast cancer cells.	rottlerin	0-9	cyclin D1	Homo sapiens	45-54
18261747-4	2008	The growth arrest evoked by Rottlerin was not mediated by cell-cycle inhibitors p21 and p27 but was accompanied by a dramatic fall in the cyclin-D1 protein, the levels of which were not altered by the pan-PKC inhibitor GF 109203X, thus excluding a PKC-mediated mechanism in the Rottlerin effect.	rottlerin	28-37	cyclin D1	Homo sapiens	138-147
18323654-6	2008	Consequently, quercetin stimulated p21 expression and suppressed cyclin D1 expression in favor of cell cycle arrest.	Quercetin	14-23	cyclin D1	Homo sapiens	65-74
18316600-2	2008	Curcumin inhibits cancer cell proliferation in part by suppressing cyclin D1 and inducing expression of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1).	Curcumin	0-8	cyclin D1	Homo sapiens	67-76
18239461-9	2008	Estradiol, which induced cyclin D1 abundance, was associated with a reduction in recruitment of the co-repressors HP1alpha/HDAC1 to the endogenous cyclin D1 promoter AP-1/BRG-1 binding sites.	Estradiol	0-9	cyclin D1	Homo sapiens	25-34
18239461-9	2008	Estradiol, which induced cyclin D1 abundance, was associated with a reduction in recruitment of the co-repressors HP1alpha/HDAC1 to the endogenous cyclin D1 promoter AP-1/BRG-1 binding sites.	Estradiol	0-9	cyclin D1	Homo sapiens	147-156
18058799-7	2008	Subsequently, 6-gingerol suppressed cyclin D1 expression and induced NAG-1 expression.	gingerol	14-24	cyclin D1	Homo sapiens	36-45
18303407-3	2008	We established cyclin D1 expression level in 116 frozen and formalin-fixed, paraffin-embedded primary tumors from patients diagnosed with a variety of B-cell lymphoproliferative disorders.	Formaldehyde	60-68	cyclin D1	Homo sapiens	15-24
18303407-3	2008	We established cyclin D1 expression level in 116 frozen and formalin-fixed, paraffin-embedded primary tumors from patients diagnosed with a variety of B-cell lymphoproliferative disorders.	Paraffin	76-84	cyclin D1	Homo sapiens	15-24
18288380-7	2008	Apicidin attenuated the expression of cyclin E and CDK2 in MCF10A cells, decreased cyclin D1 and cyclin E levels in MCF10A-ras cells, and increased the levels of CDK inhibitors, p21WAF1/Cip1 and p27Kip1, in both cell lines.	apicidin	0-8	cyclin D1	Homo sapiens	83-92
18058799-10	2008	The results suggest that 6-gingerol stimulates apoptosis through upregulation of NAG-1 and G(1) cell cycle arrest through downregulation of cyclin D1.	gingerol	25-35	cyclin D1	Homo sapiens	140-149
17724476-3	2008	In MCF7 breast adenocarcinoma cells, rapamycin decreases levels of cyclin D1, without affecting cytoplasmic levels of its mRNA.	Sirolimus	37-46	cyclin D1	Homo sapiens	67-76
18163422-10	2008	Galiellalactone inhibited Stat3-mediated luciferase activity (IC(50) approximately 5 microM) and reduced the expression of Bcl-2, Bcl-x(L), c-myc, and cyclin D1.	galiellalactone	0-15	cyclin D1	Homo sapiens	151-160
18478976-0	2008	Different patterns of cyclin D1/CDK4-E2F-1/4 pathways in human embryo lung fibroblasts treated by benzo[a]pyrene at different doses.	Benzo(a)pyrene	98-112	cyclin D1	Homo sapiens	22-31
18063576-4	2008	Inhibition of the 26 S proteasome with MG132 rescued cyclin D1 protein levels, indicating that rather than inhibiting translation, PKR and PERK act to increase cyclin D1 degradation.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	39-44	cyclin D1	Homo sapiens	53-62
18063576-7	2008	Furthermore, this degradation is independent of phosphorylation of cyclin D1 at threonine 286, which is mediated by the glycogen synthase kinase 3beta and mitogen-activated protein kinase pathways as described in previous studies.	Threonine	80-89	cyclin D1	Homo sapiens	67-76
18245487-0	2008	Tamoxifen stimulates the growth of cyclin D1-overexpressing breast cancer cells by promoting the activation of signal transducer and activator of transcription 3.	Tamoxifen	0-9	cyclin D1	Homo sapiens	35-44
18245487-4	2008	In contrast, molecular pathways linking overexpression of cyclin D1 to tamoxifen resistance have not been established.	Tamoxifen	71-80	cyclin D1	Homo sapiens	58-67
18245487-5	2008	In the current study, the effect of tamoxifen on the growth of genetically matched high or low cyclin D1-expressing breast cancer cells was characterized and the interactions between cyclin D1, ER, and STAT3 in response to tamoxifen treatment were determined.	Tamoxifen	36-45	cyclin D1	Homo sapiens	95-104
18245487-5	2008	In the current study, the effect of tamoxifen on the growth of genetically matched high or low cyclin D1-expressing breast cancer cells was characterized and the interactions between cyclin D1, ER, and STAT3 in response to tamoxifen treatment were determined.	Tamoxifen	223-232	cyclin D1	Homo sapiens	183-192
18245487-6	2008	We show that repression of STAT3 by cyclin D1 inhibits cell growth on Matrigel and in tumors in vivo; however, treatment with tamoxifen abolishes cyclin D1-mediated repression of STAT3 and growth suppression.	Tamoxifen	126-135	cyclin D1	Homo sapiens	146-155
18245487-7	2008	We show that tamoxifen induces a redistribution of cyclin D1 from STAT3 to the ER, which results in the activation of both STAT3 and the ER.	Tamoxifen	13-22	cyclin D1	Homo sapiens	51-60
18245487-8	2008	These results offer a molecular mechanism for the dual effect of cyclin D1 overexpression in breast cancer and support the notion that the level of cyclin D1 expression and activated STAT3 are important markers to predict response to tamoxifen treatment.	Tamoxifen	234-243	cyclin D1	Homo sapiens	65-74
18245487-8	2008	These results offer a molecular mechanism for the dual effect of cyclin D1 overexpression in breast cancer and support the notion that the level of cyclin D1 expression and activated STAT3 are important markers to predict response to tamoxifen treatment.	Tamoxifen	234-243	cyclin D1	Homo sapiens	148-157
18061162-8	2008	Bay 11-7082 blocked TNF alpha capacity to induce cell proliferation and up-regulation of cyclin D1 and of Bcl-xLin vivo and in vitro.	3-(4-methylphenylsulfonyl)-2-propenenitrile	0-11	cyclin D1	Homo sapiens	89-98
17935127-6	2008	Accumulation of dephospho-beta-catenin (nondegraded form) parallel with Bcl-2 and Cyclin D1 downregulation was also achieved after 2-ME(2) treatment.	Mercaptoethanol	131-135	cyclin D1	Homo sapiens	82-91
17671518-5	2008	Cyclin D1 and A levels are constitutively lower in HTSF compared to NADF, and the cyclin-dependent kinase inhibitor p21(cip1) is upregulated in HTSF and located in the nucleus.	nadf	68-72	cyclin D1	Homo sapiens	0-9
17989348-3	2008	beta-CDODA-Me induced p21 and p27, down-regulated cyclin D1 protein expression, and induced two other proapoptotic proteins, namely nonsteroidal anti-inflammatory drug-activated gene-1 and activating transcription factor-3.	beta-cdoda-me	0-13	cyclin D1	Homo sapiens	50-59
18314491-7	2008	KLF4 knockdown using short interference RNA significantly weakens the effects of selenium on DNA synthesis inhibition, apoptosis induction, and the expression of three KLF4 target genes, cyclin D1, p21/WAF1, and p27/Kip1.	Selenium	81-89	cyclin D1	Homo sapiens	187-196
18223228-7	2008	Immunoblot and immunohistochemical analysis was used to assess the effect of flavopiridol on cyclin D1 and p21 expression in vitro and in vivo, respectively.	alvocidib	77-89	cyclin D1	Homo sapiens	93-102
18339887-6	2008	Antiproliferative and proapoptotic effects of silibinin were associated with down-regulation of extracellular signal-regulated kinase 1/2 (ERK1/2) and Akt phosphorylation as well as cyclin D1 expression.	Silybin	46-55	cyclin D1	Homo sapiens	182-191
18347178-0	2008	Cyclin D1 expression in breast cancer patients receiving adjuvant tamoxifen-based therapy.	Tamoxifen	66-75	cyclin D1	Homo sapiens	0-9
18223228-10	2008	Flavopiridol (at 7.5 mg/kg) significantly inhibited the growth of xenografted rhabdoid tumors, and its effect was correlated with the induction of p21 and down-modulation of cyclin D1.	alvocidib	0-12	cyclin D1	Homo sapiens	174-183
17637756-2	2008	Incubation of confluent cell cultures with nontoxic/nonclastogenic concentrations of the flavoprotein inhibitor, diphenyleneiodonium (DPI), reduced nicotinamide adenine dinucleotide phosphate (NAD(P)H) oxidase activity and basal ROS levels, but increased proteolysis of cyclin D1, p21(Waf1) and phospho-p38(MAPK).	NADP	148-191	cyclin D1	Homo sapiens	270-279
17637753-3	2008	We found that AP-1 blockade by Tam67 in MCF-7 breast cancer cells downregulates cyclin D1 transcriptional activity by at least two mechanisms: by suppressing transcription at the known AP-1 binding site (-934/-928) and by suppressing growth factor-induced expression through suppressing E2F activation at the E2F-responsive site (-726/-719).	tam67	31-36	cyclin D1	Homo sapiens	80-89
17700539-7	2008	Transcriptional activation of c-myc and cyclin D1 promoters by nuclear IRS-1 does not occur with a mutant, inactive IRS-1 protein (deletion of the phosphotyrosine-binding domain, PTB) and does not require PI3-kinase activity.	Phosphotyrosine	147-162	cyclin D1	Homo sapiens	40-49
18275596-5	2008	We also assessed p,p"-DDE-induced modifications in cell cycle entry and the expression of the sex-steroid-dependent genes ESR1, AR, CCND1, and TFF1 (pS2) (mRNA and/or protein).	Dichlorodiphenyl Dichloroethylene	17-25	cyclin D1	Homo sapiens	132-137
18327303-6	2008	Incubation of tumor cells with pioglitazone resulted in increased levels of p53 and p27 and decreased levels of cyclin D1.	Pioglitazone	31-43	cyclin D1	Homo sapiens	112-121
18618300-0	2008	Inverse correlation of aberrant expression of fragile histidine triad (FHIT) protein with cyclin D1 protein and prognosis in Chinese patients with cholangiocarcinoma.	Histidine	54-63	cyclin D1	Homo sapiens	90-99
18275596-8	2008	DHT added together with E2 to the cell culture medium decreased the recruitment of CAMA-1 cells in the S phase and the expression of ESR1 and CCND1 by comparison with cells treated with E2 alone.	Dihydrotestosterone	0-3	cyclin D1	Homo sapiens	142-147
18823530-2	2008	We have previously reported amplification of one such oncogene, namely CCND1, to be correlated with an adverse effect of tamoxifen in premenopausal breast cancer patients.	Tamoxifen	121-130	cyclin D1	Homo sapiens	71-76
18823530-3	2008	Over-expression of cyclin D1 protein, however, confers tamoxifen resistance but not a tamoxifen-induced adverse effect.	Tamoxifen	55-64	cyclin D1	Homo sapiens	19-28
17938578-8	2008	Gossypol-induced cell cycle arrest was accompanied by decreased expression of cyclin D1 in Ramos cells.	Gossypol	0-8	cyclin D1	Homo sapiens	78-87
18196959-17	2008	The number of cyclin D1-staining cells was clearly higher (p &lt; 0.05) in peritum-HBT than in non-tumorous pre- or postm-HBT, but the response cyclin D1 to all hormonal treatments in peritum-HBT was the same as in postm-HBT.	hbt	83-86	cyclin D1	Homo sapiens	14-23
18196959-0	2008	Effects of estradiol and medroxyprogesterone acetate on expression of the cell cycle proteins cyclin D1, p21 and p27 in cultured human breast tissues.	Estradiol	11-20	cyclin D1	Homo sapiens	94-103
18196959-0	2008	Effects of estradiol and medroxyprogesterone acetate on expression of the cell cycle proteins cyclin D1, p21 and p27 in cultured human breast tissues.	Medroxyprogesterone Acetate	25-52	cyclin D1	Homo sapiens	94-103
18196959-17	2008	The number of cyclin D1-staining cells was clearly higher (p &lt; 0.05) in peritum-HBT than in non-tumorous pre- or postm-HBT, but the response cyclin D1 to all hormonal treatments in peritum-HBT was the same as in postm-HBT.	hbt	122-125	cyclin D1	Homo sapiens	14-23
18196959-17	2008	The number of cyclin D1-staining cells was clearly higher (p &lt; 0.05) in peritum-HBT than in non-tumorous pre- or postm-HBT, but the response cyclin D1 to all hormonal treatments in peritum-HBT was the same as in postm-HBT.	hbt	122-125	cyclin D1	Homo sapiens	14-23
18196959-17	2008	The number of cyclin D1-staining cells was clearly higher (p &lt; 0.05) in peritum-HBT than in non-tumorous pre- or postm-HBT, but the response cyclin D1 to all hormonal treatments in peritum-HBT was the same as in postm-HBT.	hbt	122-125	cyclin D1	Homo sapiens	14-23
17976956-3	2008	OSM treatment significantly reduced levels of cyclin D1 protein and phosphorylation of retinoblastoma protein (Rb) at Ser-795, a CDK4-specific phosphorylation site.	Serine	118-121	cyclin D1	Homo sapiens	46-55
18769058-8	2008	rhHAPO enhanced the expression of cyclin D1, where as LY294002 inhibited the up-regulation of cyclin D1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	cyclin D1	Homo sapiens	34-43
18769058-8	2008	rhHAPO enhanced the expression of cyclin D1, where as LY294002 inhibited the up-regulation of cyclin D1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	54-62	cyclin D1	Homo sapiens	94-103
17976956-5	2008	Results obtained with lactacystin, a proteasome inhibitor, demonstrated that cyclin D1 reduction occurred through ubiquitin/proteasome proteolysis.	lactacystin	22-33	cyclin D1	Homo sapiens	77-86
17943175-10	2008	Treatment with short hairpin RNAs targeting either CCND1 or c-Mos further sensitized MV4-11 cells to ABT-869.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	101-104	cyclin D1	Homo sapiens	51-56
18840136-9	2008	Acid and bile acid exposure also increased levels of cyclin D1, a G1 to S cell cycle regulator.	Bile Acids and Salts	9-18	cyclin D1	Homo sapiens	53-62
18840136-11	2008	Sorafenib abrogated MAPK activation and cyclin D1 up-regulation and significantly inhibited cell growth.	Sorafenib	0-9	cyclin D1	Homo sapiens	40-49
18197291-0	2008	PI-3K/Akt pathway-dependent cyclin D1 expression is responsible for arsenite-induced human keratinocyte transformation.	arsenite	68-76	cyclin D1	Homo sapiens	28-37
18197291-3	2008	OBJECTIVES: In this study, we investigated the potential role of PI-3K/Akt/cyclin D1in the transformation of human keratinocytic cells upon arsenite exposure.	arsenite	140-148	cyclin D1	Homo sapiens	75-84
18197291-9	2008	Furthermore, our data also indicated that cyclin D1 is an important downstream molecule involved in PI-3K/Akt-mediated cell transformation upon arsenite exposure based on the facts that inhibition of cyclin D1 expression by dominant negative mutants of PI-3K, and Akt, or the knockdown of the cyclin D1 expression by its specific siRNA in the HaCat cells resulted in impairing of anchorage-independent growth of HaCat cells induced by arsenite.	arsenite	144-152	cyclin D1	Homo sapiens	42-51
18197291-9	2008	Furthermore, our data also indicated that cyclin D1 is an important downstream molecule involved in PI-3K/Akt-mediated cell transformation upon arsenite exposure based on the facts that inhibition of cyclin D1 expression by dominant negative mutants of PI-3K, and Akt, or the knockdown of the cyclin D1 expression by its specific siRNA in the HaCat cells resulted in impairing of anchorage-independent growth of HaCat cells induced by arsenite.	arsenite	144-152	cyclin D1	Homo sapiens	200-209
18197291-9	2008	Furthermore, our data also indicated that cyclin D1 is an important downstream molecule involved in PI-3K/Akt-mediated cell transformation upon arsenite exposure based on the facts that inhibition of cyclin D1 expression by dominant negative mutants of PI-3K, and Akt, or the knockdown of the cyclin D1 expression by its specific siRNA in the HaCat cells resulted in impairing of anchorage-independent growth of HaCat cells induced by arsenite.	arsenite	144-152	cyclin D1	Homo sapiens	200-209
18197291-9	2008	Furthermore, our data also indicated that cyclin D1 is an important downstream molecule involved in PI-3K/Akt-mediated cell transformation upon arsenite exposure based on the facts that inhibition of cyclin D1 expression by dominant negative mutants of PI-3K, and Akt, or the knockdown of the cyclin D1 expression by its specific siRNA in the HaCat cells resulted in impairing of anchorage-independent growth of HaCat cells induced by arsenite.	arsenite	435-443	cyclin D1	Homo sapiens	42-51
18197291-10	2008	CONCLUSION: Our results demonstrate that PI-3K/Akt-mediated cyclin D1 expression is at least one key event implicated in the arsenite human skin carcinogenic effect.	arsenite	125-133	cyclin D1	Homo sapiens	60-69
17486587-4	2008	When treated with PKC alpha antisense oligonucleotides (ODN), both HA22T/VGH and SK-Hep-1 cells lines showed the reduction of PKC alpha expression, as well as a deceleration in the growth rate and in the level of cyclin D1, but the increase in the levels of p53 and p21(WAF1/CIP1).	Oligonucleotides	38-54	cyclin D1	Homo sapiens	213-222
19202962-12	2008	CONCLUSION: The advanced clinical stage, cyclin D1 and Her-2 gene amplifications represent factors, predicting the failure of adjuvant tamoxifen treatment, but their predictive value is much lower in patients receiving adjuvant chemotherapy.	Tamoxifen	135-144	cyclin D1	Homo sapiens	41-50
18034278-5	2008	Flow cytometry revealed significant increases in three of four lung cancer cell lines in apoptosis and necrosis after lovastatin treatment at 10 microM for 72 h. Lovastatin adversely affected lung cancer cell survival with increases in cell-cycle check-point inhibitors p21WAF and/or p27KIP and a decrease in cyclin D1.	Lovastatin	118-128	cyclin D1	Homo sapiens	309-318
18034278-5	2008	Flow cytometry revealed significant increases in three of four lung cancer cell lines in apoptosis and necrosis after lovastatin treatment at 10 microM for 72 h. Lovastatin adversely affected lung cancer cell survival with increases in cell-cycle check-point inhibitors p21WAF and/or p27KIP and a decrease in cyclin D1.	Lovastatin	162-172	cyclin D1	Homo sapiens	309-318
18165447-1	2008	BACKGROUND: In vitro, butyrate inhibits histone deacetylase and down-regulates expression of cyclin D1.	Butyrates	22-30	cyclin D1	Homo sapiens	93-102
18165447-7	2008	Cyclin D1 expression was increased 6.5-fold by lactulose feeding (p = .02) but decreased 50% with cecal butyrate infusion (p = .004).	Lactulose	47-56	cyclin D1	Homo sapiens	0-9
18165447-7	2008	Cyclin D1 expression was increased 6.5-fold by lactulose feeding (p = .02) but decreased 50% with cecal butyrate infusion (p = .004).	cecal butyrate	98-112	cyclin D1	Homo sapiens	0-9
18165447-9	2008	Thus, bacterial production and exogenous infusion of butyrate have opposite effects on histone acetylation and cyclin D1 expression, suggesting that the composition of bacterial flora may play a role in butyrate"s in vivo effects on the cell cycle.	Butyrates	53-61	cyclin D1	Homo sapiens	111-120
18165447-9	2008	Thus, bacterial production and exogenous infusion of butyrate have opposite effects on histone acetylation and cyclin D1 expression, suggesting that the composition of bacterial flora may play a role in butyrate"s in vivo effects on the cell cycle.	Butyrates	203-211	cyclin D1	Homo sapiens	111-120
18773862-7	2008	Cyclin D1 expression was increased in the SB- and ATRA + SB-treated groups, but inhibited in the ATRA-treated group.	Butyric Acid	42-44	cyclin D1	Homo sapiens	0-9
18773862-7	2008	Cyclin D1 expression was increased in the SB- and ATRA + SB-treated groups, but inhibited in the ATRA-treated group.	Tretinoin	50-54	cyclin D1	Homo sapiens	0-9
18773862-7	2008	Cyclin D1 expression was increased in the SB- and ATRA + SB-treated groups, but inhibited in the ATRA-treated group.	Butyric Acid	57-59	cyclin D1	Homo sapiens	0-9
18773862-7	2008	Cyclin D1 expression was increased in the SB- and ATRA + SB-treated groups, but inhibited in the ATRA-treated group.	Tretinoin	97-101	cyclin D1	Homo sapiens	0-9
17951252-6	2007	Inhibitory Ser-9 phosphorylation of glycogen synthase kinase 3beta (GSK3beta) by Akt prevented proteasome-mediated cyclin D1 degradation and induced cell cycle progress in LeTx-intoxicated THP-1 cells.	Serine	11-14	cyclin D1	Homo sapiens	115-124
18374204-3	2008	Our laboratory findings revealed that the inhibitory effect of vitamin K2 against HCC cell growth was generated by suppressing cyclin D1 expression through inhibition of NF-kappaB activation.	Vitamin K 2	63-73	cyclin D1	Homo sapiens	127-136
18161920-14	2007	Cyclin D1 mRNA expression was lower in the MSC group than that in the DMSO group (P &lt; 0.05).	Dimethyl Sulfoxide	70-74	cyclin D1	Homo sapiens	0-9
17951252-8	2007	Furthermore, pretreatment with LeTx or the GSK3-specific inhibitor SB-216763, or transfection with dominant active mutant Akt or degradation-defected mutant cyclin D1 protected cells from LeTx-induced cell cycle arrest, on-going MEK1 cleavage and suppression of TNF production.	letx	188-192	cyclin D1	Homo sapiens	157-166
17869226-5	2007	When analyzing the expression of cell cycle-related proteins, we found that DHTS reduced cyclin D1, cyclin D3, cyclin E, and CDK4 expression, and increased CDK inhibitor p27 expression in a dose-dependent manner.	dhts	76-80	cyclin D1	Homo sapiens	89-98
18045953-5	2007	In surviving cells, both inhibitors were even stronger than ICI in depleting cyclin D1 levels, inducing expression of the cyclin kinase inhibitor p21Waf1/Cip1, blocking phosphorylation of the retinoblastoma protein, or inhibiting cell growth.	ici	60-63	cyclin D1	Homo sapiens	77-86
18156803-5	2007	Curcumin induced the expression of cyclin-dependent kinase (CDK) inhibitors p16(/INK4a), p21(/WAF1/CIP1) and p27(/KIP1), and inhibited the expression of cyclin E and cyclin D1, and hyperphosphorylation of retinoblastoma (Rb) protein.	Curcumin	0-8	cyclin D1	Homo sapiens	166-175
18156803-6	2007	Lactacystin, an inhibitor of 26 proteasome, blocks curcumin-induced down-regulation of cyclin D1 and cyclin E proteins, suggesting their regulation at level of posttranslation.	lactacystin	0-11	cyclin D1	Homo sapiens	87-96
18156803-6	2007	Lactacystin, an inhibitor of 26 proteasome, blocks curcumin-induced down-regulation of cyclin D1 and cyclin E proteins, suggesting their regulation at level of posttranslation.	Curcumin	51-59	cyclin D1	Homo sapiens	87-96
18156803-7	2007	The suppression of cyclin D1 and cyclin E by curcumin may inhibit CDK-mediated phosphorylation of pRb protein.	Curcumin	45-53	cyclin D1	Homo sapiens	19-28
18059167-4	2007	When combined with cisplatin, YC-1 further promoted tumor cell apoptosis, decreased the expression of P-Stat3(705), Bcl-xL, CyclinD1 and survivin, and induced the cleavage of caspase 9 and PARP.	Cisplatin	19-28	cyclin D1	Homo sapiens	124-132
17879940-6	2007	The inhibition of cell proliferation was associated with a blockade of DHT-induced cyclin A and cyclin D1 expression by alphaE2 and betaE2.	Dihydrotestosterone	71-74	cyclin D1	Homo sapiens	96-105
17849471-0	2007	Serum and forskolin cooperate to promote G1 progression in Schwann cells by differentially regulating cyclin D1, cyclin E1, and p27Kip expression.	Colforsin	10-19	cyclin D1	Homo sapiens	102-111
17982676-6	2007	Compared to 5-FU-treated TP53-proficient HCT116 cultures, 5-FU-treated TP53-depleted HCT116 cultures showed lack of CDKN1A induction, decreased apoptotic levels, decreased FAS and TNFRSF10B transcript levels and cleaved PARP protein levels, G1/S transition arrests, decreased CCND1 protein levels, and smaller intra-S phase arrests.	Fluorouracil	58-62	cyclin D1	Homo sapiens	276-281
17879940-8	2007	CONCLUSION: alphaE2 is an effective agent for inhibition of DHT-induced PSA, cyclin A, cyclin D1 gene expression, and cell proliferation in LAPC-4 cells, and tumor growth in LAPC-4 xenograft mice.	Dihydrotestosterone	60-63	cyclin D1	Homo sapiens	87-96
18006776-4	2007	RESULTS: PPARgamma is overexpressed in ACHN cells and barely detectable in 786-0 cells, and treatment with DIM-C-pPhtBu induces proteasome-dependent degradation of cyclin D1 and variable effects on p21 and p27 expression in both cell lines.	1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane	107-119	cyclin D1	Homo sapiens	164-173
17124554-0	2007	A synthetic uracil derivative with antitumor activity through decreasing cyclin D1 and Cdk1, and increasing p21 and p27 in MCF-7 cells.	Uracil	12-18	cyclin D1	Homo sapiens	73-82
17124554-3	2007	Using a reverse transcription-polymerase chain reaction-based assay at a dose of 5 muM of DBDU cyclin D1 mRNA was decreased, suggesting that DBDU exerts its regulatory action on cyclin D1 at the level of transcription.	dbdu	90-94	cyclin D1	Homo sapiens	95-104
17124554-3	2007	Using a reverse transcription-polymerase chain reaction-based assay at a dose of 5 muM of DBDU cyclin D1 mRNA was decreased, suggesting that DBDU exerts its regulatory action on cyclin D1 at the level of transcription.	dbdu	90-94	cyclin D1	Homo sapiens	178-187
17516137-6	2007	Through interfering with the cell cycle of tumor cells, PS may induce apoptosis by downregulating the expression level of cyclin D1 and upregulating the level of p21 protein.	Polysaccharides	56-58	cyclin D1	Homo sapiens	122-131
17784872-5	2007	JTP-70902 also induced another CDK-inhibitor, p27(KIP1), and downregulated the expression of c-Myc and cyclin D1, resulting in G(1) cell cycle arrest.	N-(3-(5-(4-bromo-2-fluorophenylamino)-3-cyclopropyl-8-methyl-2,4,7-trioxo-3,4,7,8-tetrahydro-2H-pyrido(2,3-d)pyrimidin-1-yl)phenyl)methanesulfonamide	0-9	cyclin D1	Homo sapiens	103-112
17927591-3	2007	Cyclin D1 and p16 were both significantly more likely to be expressed in the neoplastic than in the normal epithelial and stromal components of PA and CXPA (P &lt; 0.001 and P &lt; 0.005, respectively).	cxpa	151-155	cyclin D1	Homo sapiens	0-9
17927591-4	2007	Cyclin D1 was more likely to be expressed in the malignant components of CXPA than in the benign components of PA (50% versus 31% and 31%, respectively), but the trend was not statistically significant.	cxpa	73-77	cyclin D1	Homo sapiens	0-9
17927591-6	2007	CONCLUSIONS: Our findings provide preliminary evidence of roles for cyclin D1 and p16 in the development of PA and for cyclin D1 in the progression of PA to CXPA.	cxpa	157-161	cyclin D1	Homo sapiens	119-128
17919228-7	2007	Cyclin D1 and c-myc, target molecules of Wnt signalling, were frequently positive in the IPNB lineage (65 and 54% respectively), and interestingly nuclear beta-catenin staining, reflecting activation of Wnt signalling, was observed only in the IPNB lineage (22%) (P&lt;0.05).	ipnb	89-93	cyclin D1	Homo sapiens	0-9
17477349-5	2007	Next, with Western blotting, we discovered that TAM67 impaired the cyclin D1/cdk4 complex but had little effect on the cyclin E/cdk2 complex, concomitantly with inhibiting Rb phosphorylation.	tam67	48-53	cyclin D1	Homo sapiens	67-76
18025264-4	2007	In addition, to block the ER/Src interaction, the phosphopeptide inhibits Src/Erk pathway, cyclin D1 expression, and DNA synthesis induced by estradiol or androgen or triggered by epidermal growth factor.	Estradiol	142-151	cyclin D1	Homo sapiens	91-100
18226366-1	2007	OBJECTIVE: To explore the relationship between genetic polymorphism of P53, P21, CCND1 and susceptibility of chromosomal damage induced by vinyl chloride monomer (VCM).	Vinyl Chloride	139-153	cyclin D1	Homo sapiens	81-86
17486065-0	2007	Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer.	Tamoxifen	64-73	cyclin D1	Homo sapiens	17-22
17486065-4	2007	Here, we investigate the prognostic and treatment predictive role of CCND1 and PAK1 gene amplification in postmenopausal breast cancer patients randomized to tamoxifen treatment or no adjuvant treatment.	Tamoxifen	158-167	cyclin D1	Homo sapiens	69-74
17698033-4	2007	Mahanine-induced expression of RASSF1A in turn significantly reduced cyclin D1 but not other cyclins.	mahanine	0-8	cyclin D1	Homo sapiens	69-78
17698033-5	2007	To understand the inverse relationship between RASSF1A and cyclin D1, we observed that mahanine treatment down-regulates cyclin D1 and addition of RASSF1A siRNA prevented this inhibition.	mahanine	87-95	cyclin D1	Homo sapiens	59-68
17698033-5	2007	To understand the inverse relationship between RASSF1A and cyclin D1, we observed that mahanine treatment down-regulates cyclin D1 and addition of RASSF1A siRNA prevented this inhibition.	mahanine	87-95	cyclin D1	Homo sapiens	121-130
17486077-4	2007	Treatment of the human prostate or mammary cancer cells (LNCaP or MCF-7, respectively) with nanomolar concentrations of this peptide inhibits the androgen- or estradiol-induced association between the AR or the ER and Src the Src/Erk pathway activation, cyclin D1 expression and DNA synthesis, without interfering in the receptor-dependent transcriptional activity.	Estradiol	159-168	cyclin D1	Homo sapiens	254-263
17596533-6	2007	Moreover, NAC and taurine increased cyclin D1/cdk4 activation and suppressed p21(Waf1/Cip1) and p27(Kip1) expression in HG-treated cells.	Acetylcysteine	10-13	cyclin D1	Homo sapiens	36-45
17596533-6	2007	Moreover, NAC and taurine increased cyclin D1/cdk4 activation and suppressed p21(Waf1/Cip1) and p27(Kip1) expression in HG-treated cells.	Taurine	18-25	cyclin D1	Homo sapiens	36-45
17823285-5	2007	Increased cyclin D1 levels, CDK4 activity, and Rb protein phosphorylation were observed in 1-week balloon-injured arteries compared with uninjured arteries, and these responses were also suppressed by adenovirus-mediated expression of dnSTAT-5B.	dnstat	235-241	cyclin D1	Homo sapiens	10-19
17619075-2	2007	Cells were treated with cyclopentenone or 17beta-estradiol to modulate the level of expression of cyclin D1 mRNA.	cyclopentenone	24-38	cyclin D1	Homo sapiens	98-107
17619075-2	2007	Cells were treated with cyclopentenone or 17beta-estradiol to modulate the level of expression of cyclin D1 mRNA.	Estradiol	42-58	cyclin D1	Homo sapiens	98-107
17619075-5	2007	We suggest these variations might be associated with the effects of cyclopentenone and 17beta-estradiol in cyclin D1 gene expression.	cyclopentenone	68-82	cyclin D1	Homo sapiens	107-116
17619075-5	2007	We suggest these variations might be associated with the effects of cyclopentenone and 17beta-estradiol in cyclin D1 gene expression.	Estradiol	87-103	cyclin D1	Homo sapiens	107-116
17606765-0	2007	Suberoylanilide hydroxamic acid (SAHA; vorinostat) suppresses translation of cyclin D1 in mantle cell lymphoma cells.	Vorinostat	0-31	cyclin D1	Homo sapiens	77-86
17606765-0	2007	Suberoylanilide hydroxamic acid (SAHA; vorinostat) suppresses translation of cyclin D1 in mantle cell lymphoma cells.	Vorinostat	33-37	cyclin D1	Homo sapiens	77-86
17606765-0	2007	Suberoylanilide hydroxamic acid (SAHA; vorinostat) suppresses translation of cyclin D1 in mantle cell lymphoma cells.	Vorinostat	39-49	cyclin D1	Homo sapiens	77-86
17606765-2	2007	We showed that suberoylanilide hydroxamic acid (SAHA; vorinostat), one of the histone deacetylase inhibitors derived from hydroxamic acid, caused a dramatic decrease (90%) in protein levels of cyclin D1 after 8-hour exposure to SAHA (5 muM) in MCL lines (SP49, SP53, Jeko1).	Vorinostat	15-46	cyclin D1	Homo sapiens	193-202
17606765-2	2007	We showed that suberoylanilide hydroxamic acid (SAHA; vorinostat), one of the histone deacetylase inhibitors derived from hydroxamic acid, caused a dramatic decrease (90%) in protein levels of cyclin D1 after 8-hour exposure to SAHA (5 muM) in MCL lines (SP49, SP53, Jeko1).	Vorinostat	48-52	cyclin D1	Homo sapiens	193-202
17606765-2	2007	We showed that suberoylanilide hydroxamic acid (SAHA; vorinostat), one of the histone deacetylase inhibitors derived from hydroxamic acid, caused a dramatic decrease (90%) in protein levels of cyclin D1 after 8-hour exposure to SAHA (5 muM) in MCL lines (SP49, SP53, Jeko1).	Vorinostat	54-64	cyclin D1	Homo sapiens	193-202
17606765-2	2007	We showed that suberoylanilide hydroxamic acid (SAHA; vorinostat), one of the histone deacetylase inhibitors derived from hydroxamic acid, caused a dramatic decrease (90%) in protein levels of cyclin D1 after 8-hour exposure to SAHA (5 muM) in MCL lines (SP49, SP53, Jeko1).	Hydroxamic Acids	31-46	cyclin D1	Homo sapiens	193-202
17606765-2	2007	We showed that suberoylanilide hydroxamic acid (SAHA; vorinostat), one of the histone deacetylase inhibitors derived from hydroxamic acid, caused a dramatic decrease (90%) in protein levels of cyclin D1 after 8-hour exposure to SAHA (5 muM) in MCL lines (SP49, SP53, Jeko1).	Vorinostat	228-232	cyclin D1	Homo sapiens	193-202
17606765-4	2007	In contrast, metabolic labeling assays showed that SAHA decreased incorporation of [(35)S]methionine into cyclin D1 protein.	Vorinostat	51-55	cyclin D1	Homo sapiens	106-115
17606765-4	2007	In contrast, metabolic labeling assays showed that SAHA decreased incorporation of [(35)S]methionine into cyclin D1 protein.	[(35)s]methionine	83-100	cyclin D1	Homo sapiens	106-115
17606765-7	2007	Taken together, SAHA caused a rapid decrease of cyclin D1 in MCL by blocking the translation of cyclin D1 by inhibiting the phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR/eIF4E-BP pathway, probably by PI3K inhibition.	Vorinostat	16-20	cyclin D1	Homo sapiens	48-57
17606765-7	2007	Taken together, SAHA caused a rapid decrease of cyclin D1 in MCL by blocking the translation of cyclin D1 by inhibiting the phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR/eIF4E-BP pathway, probably by PI3K inhibition.	Vorinostat	16-20	cyclin D1	Homo sapiens	96-105
17909054-6	2007	In synchronized cells, sorafenib causes a reversible G1 delay, which is associated with decreased levels of cyclin D1, Rb, and phosphorylation of Rb.	Sorafenib	23-32	cyclin D1	Homo sapiens	108-117
17563903-0	2007	Prognostic significance of cyclin D1 and p16 in patients with intermediate-risk head and neck squamous cell carcinoma treated with docetaxel and concurrent radiotherapy.	Docetaxel	131-140	cyclin D1	Homo sapiens	27-36
17563903-1	2007	BACKGROUND: The current study aimed to evaluate the significance of the cell-cycle-control proteins cyclin D1 and p16 as prognostic markers in head and neck squamous cell carcinoma (HNSCC) patients treated with docetaxel and radiotherapy.	Docetaxel	211-220	cyclin D1	Homo sapiens	100-109
17909257-5	2007	METHODS: We designed a CCND1-specific peptide nucleic acid (PNA) hybridization sequence (CTGGTGTTCCAT), separated by a C-terminal spacer to a cyclized IGF1 peptide analog (d-Cys-Ser-Lys-Cys), for IGF1R-mediated endocytosis.	Cysteine	174-177	cyclin D1	Homo sapiens	23-28
18306533-2	2007	Cyclin D1 immunohistochemistry was performed on 2-4 mm thick paraffin sections using labelled streptavidin biotin kit.	Paraffin	61-69	cyclin D1	Homo sapiens	0-9
18306533-2	2007	Cyclin D1 immunohistochemistry was performed on 2-4 mm thick paraffin sections using labelled streptavidin biotin kit.	Biotin	107-113	cyclin D1	Homo sapiens	0-9
17909257-5	2007	METHODS: We designed a CCND1-specific peptide nucleic acid (PNA) hybridization sequence (CTGGTGTTCCAT), separated by a C-terminal spacer to a cyclized IGF1 peptide analog (d-Cys-Ser-Lys-Cys), for IGF1R-mediated endocytosis.	Serine	178-181	cyclin D1	Homo sapiens	23-28
17909257-5	2007	METHODS: We designed a CCND1-specific peptide nucleic acid (PNA) hybridization sequence (CTGGTGTTCCAT), separated by a C-terminal spacer to a cyclized IGF1 peptide analog (d-Cys-Ser-Lys-Cys), for IGF1R-mediated endocytosis.	LYS-CYS	182-189	cyclin D1	Homo sapiens	23-28
17901853-6	2007	CCND1 expression was also evaluated with an immunohistochemical method in tumor tissues of 39 patients of the PA group.	Protactinium	110-112	cyclin D1	Homo sapiens	0-5
17696482-10	2007	Pterostilbene increased the p53, p21, p27, and p16 proteins and decreased levels of cyclin A, cyclin E, cyclin-dependent kinase 2 (Cdk2), Cdk4, and Cdk6, but the expression of cyclin D1 was not affected.	pterostilbene	0-13	cyclin D1	Homo sapiens	176-185
17415779-5	2007	Cell cycle analysis showed that celecoxib and sulindac sulfide both induced a 3-fold increase in G(1) phase distribution, and this correlated with strong induction of p21(waf1/cip1), inhibition of cyclin D1, and hypophosphorylation of Rb.	Celecoxib	32-41	cyclin D1	Homo sapiens	197-206
17415779-5	2007	Cell cycle analysis showed that celecoxib and sulindac sulfide both induced a 3-fold increase in G(1) phase distribution, and this correlated with strong induction of p21(waf1/cip1), inhibition of cyclin D1, and hypophosphorylation of Rb.	sulindac sulfide	46-62	cyclin D1	Homo sapiens	197-206
17938262-3	2007	The honokiol-mediated cell cycle arrest was associated with a decrease in protein levels of cyclin D1, cyclin-dependent kinase 4 (Cdk4), Cdk6, and/or cyclin E and suppression of complex formation between cyclin D1 and Cdk4 as revealed by immunoprecipitation using anti-cyclin D1 antibody followed by immunoblotting for Cdk4 protein.	honokiol	4-12	cyclin D1	Homo sapiens	92-101
17938262-3	2007	The honokiol-mediated cell cycle arrest was associated with a decrease in protein levels of cyclin D1, cyclin-dependent kinase 4 (Cdk4), Cdk6, and/or cyclin E and suppression of complex formation between cyclin D1 and Cdk4 as revealed by immunoprecipitation using anti-cyclin D1 antibody followed by immunoblotting for Cdk4 protein.	honokiol	4-12	cyclin D1	Homo sapiens	204-213
17938262-3	2007	The honokiol-mediated cell cycle arrest was associated with a decrease in protein levels of cyclin D1, cyclin-dependent kinase 4 (Cdk4), Cdk6, and/or cyclin E and suppression of complex formation between cyclin D1 and Cdk4 as revealed by immunoprecipitation using anti-cyclin D1 antibody followed by immunoblotting for Cdk4 protein.	honokiol	4-12	cyclin D1	Homo sapiens	204-213
17670745-5	2007	Chromatin immunoprecipitation assays indicated that BAD is localized at the 12-O-tetradecanoylphorbol-13-acetate-response element (TRE) and cAMP-response element (CRE) in the cyclin D1 promoter.	Tetradecanoylphorbol Acetate	76-112	cyclin D1	Homo sapiens	175-184
17970072-8	2007	Sodium butyrate also significantly decreased the expression of the cell cycle regulatory proteins (cyclin D1/cyclin dependent kinase (CDK)4, CDK6, and cyclin E/CDK2) in the LNCaP cells after 48 h treatment.	Butyric Acid	0-15	cyclin D1	Homo sapiens	99-108
17804732-6	2007	However, overexpression of cyclin D1 in normal prostate fibroblasts (NPF) that were subsequently recombined with BPH-1 did induce malignant transformation of the epithelial cells.	bph-1	113-118	cyclin D1	Homo sapiens	27-36
17640297-0	2007	Sesamin, a lignan of sesame, down-regulates cyclin D1 protein expression in human tumor cells.	sesamin	0-7	cyclin D1	Homo sapiens	44-53
17640297-6	2007	It is also shown that inhibition of MCF-7 cell proliferation by sesamin is correlated with down-regulated cyclin D1 protein expression, a proto-oncogene that is overexpressed in many human cancer cells.	sesamin	64-71	cyclin D1	Homo sapiens	106-115
17640297-7	2007	It was found that sesamin-induced down-regulation of cyclin D1 was inhibited by proteasome inhibitors, suggesting that sesamin suppresses cyclin D1 protein expression by promoting proteasome degradation of cyclin D1 protein.	sesamin	18-25	cyclin D1	Homo sapiens	53-62
17640297-7	2007	It was found that sesamin-induced down-regulation of cyclin D1 was inhibited by proteasome inhibitors, suggesting that sesamin suppresses cyclin D1 protein expression by promoting proteasome degradation of cyclin D1 protein.	sesamin	18-25	cyclin D1	Homo sapiens	138-147
17640297-7	2007	It was found that sesamin-induced down-regulation of cyclin D1 was inhibited by proteasome inhibitors, suggesting that sesamin suppresses cyclin D1 protein expression by promoting proteasome degradation of cyclin D1 protein.	sesamin	18-25	cyclin D1	Homo sapiens	138-147
17640297-7	2007	It was found that sesamin-induced down-regulation of cyclin D1 was inhibited by proteasome inhibitors, suggesting that sesamin suppresses cyclin D1 protein expression by promoting proteasome degradation of cyclin D1 protein.	sesamin	119-126	cyclin D1	Homo sapiens	53-62
17640297-7	2007	It was found that sesamin-induced down-regulation of cyclin D1 was inhibited by proteasome inhibitors, suggesting that sesamin suppresses cyclin D1 protein expression by promoting proteasome degradation of cyclin D1 protein.	sesamin	119-126	cyclin D1	Homo sapiens	138-147
17640297-7	2007	It was found that sesamin-induced down-regulation of cyclin D1 was inhibited by proteasome inhibitors, suggesting that sesamin suppresses cyclin D1 protein expression by promoting proteasome degradation of cyclin D1 protein.	sesamin	119-126	cyclin D1	Homo sapiens	138-147
17634406-4	2007	Among the G1 phase cell cycle-related proteins, the levels of cyclin-dependent protein kinase (CDK)2, CDK6, cyclin D1, cyclin D2, cyclin D3 and cyclin E were reduced by acteoside, whereas the steady-state level of CDK4 was unaffected.	acteoside	169-178	cyclin D1	Homo sapiens	108-117
17640297-8	2007	Sesamin down-regulates cyclin D1 protein expression in various kinds of human tumor cells, including lung cancer, transformed renal cells, immortalized keratinocyte, melanoma and osteosarcoma.	sesamin	0-7	cyclin D1	Homo sapiens	23-32
17640297-9	2007	Furthermore, depletion of cyclin D1 protein using small interfering RNA rendered MCF-7 cells insensitive to the growth inhibitory effects of sesamin, implicating that cyclin D1 is at least partially related to the antiproliferative effects of sesamin.	sesamin	243-250	cyclin D1	Homo sapiens	26-35
17640297-10	2007	Taken together, these results suggest that the ability of sesamin to down-regulate cyclin D1 protein expression through the activation of proteasome degradation could be one of the mechanisms of the antiproliferative activity of this agent.	sesamin	58-65	cyclin D1	Homo sapiens	83-92
18095570-7	2007	CONCLUSION: Lycopene can induce apoptosis of PC-3, change the cell cycle distribution and downregulate the expression of cyclin D1 and bcl-2 and upregulate the expression of bax and then restrain cell proliferation.	Lycopene	12-20	cyclin D1	Homo sapiens	121-130
17443686-5	2007	We found that the decrease in cyclin D1 levels induced by NO was GSH-sensitive implying that the redox regulation of NO-mediated cytostasis was a multifaceted process and that both p53/p21(cip1/waf1) and p53 independent cyclin D1 pathways were involved.	Glutathione	65-68	cyclin D1	Homo sapiens	30-39
17443686-5	2007	We found that the decrease in cyclin D1 levels induced by NO was GSH-sensitive implying that the redox regulation of NO-mediated cytostasis was a multifaceted process and that both p53/p21(cip1/waf1) and p53 independent cyclin D1 pathways were involved.	Glutathione	65-68	cyclin D1	Homo sapiens	220-229
17453147-12	2007	In conclusion, we have provided evidence for the first time that RA may induce cell cycle arrest in vitro in DAOY MB cells via inhibition of CyclinD1 or C-myc.	Tretinoin	65-67	cyclin D1	Homo sapiens	141-149
17855663-9	2007	Ursolic acid down-regulated the expression of STAT3-regulated gene products such as cyclin D1, Bcl-2, Bcl-xL, survivin, Mcl-1, and vascular endothelial growth factor.	ursolic acid	0-12	cyclin D1	Homo sapiens	84-93
17640567-5	2007	The reducing agent also counteracted the inhibitory effects of curcumin on TNF-induced NF-kappaB-regulated antiapoptotic (Bcl-2, Bcl-xL, IAP1), proliferative (cyclin D1), and proinflammatory (COX-2, iNOS, and MMP-9) gene products.	Curcumin	63-71	cyclin D1	Homo sapiens	159-168
17617380-0	2007	Arsenic trioxide-mediated growth inhibition in gallbladder carcinoma cells via down-regulation of Cyclin D1 transcription mediated by Sp1 transcription factor.	Arsenic Trioxide	0-16	cyclin D1	Homo sapiens	98-107
17617380-2	2007	Here, we demonstrated that arsenic trioxide inhibited the proliferation of gallbladder carcinoma in vivo and in vitro as well as the transcription of cell cycle-related protein Cyclin D1.	Arsenic Trioxide	27-43	cyclin D1	Homo sapiens	177-186
17617380-3	2007	And, Cyclin D1 overexpression inhibited the negative role of arsenic trioxide in cell cycle progression.	Arsenic Trioxide	61-77	cyclin D1	Homo sapiens	5-14
17617380-4	2007	We further explored the mechanisms by which arsenic trioxide affected Cyclin D1 transcription and found that the Sp1 transcription factor was down-regulated by arsenic trioxide, with a corresponding decrease in Cyclin D1 promoter activity.	Arsenic Trioxide	44-60	cyclin D1	Homo sapiens	70-79
17617380-4	2007	We further explored the mechanisms by which arsenic trioxide affected Cyclin D1 transcription and found that the Sp1 transcription factor was down-regulated by arsenic trioxide, with a corresponding decrease in Cyclin D1 promoter activity.	Arsenic Trioxide	160-176	cyclin D1	Homo sapiens	70-79
17617380-5	2007	Taken together, these results suggested that arsenic trioxide inhibited gallbladder carcinoma cell proliferation via down-regulation of Cyclin D1 transcription in a Sp1-dependent manner, which provided a new mechanism of arsenic trioxide-involved cell proliferation and may have important therapeutic implications in gallbladder carcinoma patients.	Arsenic Trioxide	45-61	cyclin D1	Homo sapiens	136-145
17617380-5	2007	Taken together, these results suggested that arsenic trioxide inhibited gallbladder carcinoma cell proliferation via down-regulation of Cyclin D1 transcription in a Sp1-dependent manner, which provided a new mechanism of arsenic trioxide-involved cell proliferation and may have important therapeutic implications in gallbladder carcinoma patients.	Arsenic Trioxide	221-237	cyclin D1	Homo sapiens	136-145
17766653-4	2007	Western blot analysis revealed degradation of cyclin D1 and an increase in cyclin-dependent kinases p21 and p27 with VPA treatment.	Valproic Acid	117-120	cyclin D1	Homo sapiens	46-55
17699787-5	2007	Relative to indole-3-carbinol, OSU-A9 displays a striking qualitative similarity in its effects on the phosphorylation or expression of multiple signaling targets, including Akt, mitogen-activated protein kinases, Bcl-2 family members, survivin, nuclear factor-kappaB, cyclin D1, p21, and p27.	osu-a9	31-37	cyclin D1	Homo sapiens	269-278
17334399-5	2007	In particular, we have identified Ser 632 of BRCA1 as a cyclin D1/cdk4 phosphorylation site in vitro.	Serine	34-37	cyclin D1	Homo sapiens	56-65
17721086-8	2007	Iron-depletion also leads to proteasomal degradation of p21(CIP1/WAF1) and cyclin D1 via an ubiquitin-independent pathway.	Iron	0-4	cyclin D1	Homo sapiens	75-84
17310991-4	2007	Eighteen lysines in cyclin D1 had single, double or multiple mutations engineered before transfection into BEAS-2B human bronchial epithelial (HBE) cells to evaluate stabilities after all-trans-retinoic acid (RA) or cycloheximide treatments.	Lysine	9-16	cyclin D1	Homo sapiens	20-29
17310991-5	2007	Specific mutations stabilized cyclin D1, including substitutions of lysines surrounding the cyclin box domain that inhibited RA-mediated degradation and extended the cyclin D1 half-life.	Lysine	68-75	cyclin D1	Homo sapiens	30-39
17310991-5	2007	Specific mutations stabilized cyclin D1, including substitutions of lysines surrounding the cyclin box domain that inhibited RA-mediated degradation and extended the cyclin D1 half-life.	Lysine	68-75	cyclin D1	Homo sapiens	166-175
17310991-6	2007	Mutation of all cyclin D1 lysines blocked polyubiquitination.	Lysine	26-33	cyclin D1	Homo sapiens	16-25
17417771-8	2007	SAHA also decreased levels of c-myc and cyclin D1, independent of an active beta-catenin pathway.	Vorinostat	0-4	cyclin D1	Homo sapiens	40-49
17695500-4	2007	RESULTS: Cyclin D1-positive nuclear staining was overexpressed in 13/21 SCC (61.9%) and in one case of erythoplasia of Queyrat.	queyrat	119-126	cyclin D1	Homo sapiens	9-18
17640349-8	2007	beta-HCH treatment was also seen to increase the expression in a number of proto-oncogenes (c-Neu, Cyclin D1, p27), cell status markers (Met-1, CK19), and the inflammatory marker NFkappaB.	beta-hexachlorocyclohexane	0-8	cyclin D1	Homo sapiens	99-108
17420285-8	2007	UBE2D3 is physically associated with cyclin D1 and mediates ATRA-induced cyclin D1 degradation.	Tretinoin	60-64	cyclin D1	Homo sapiens	37-46
17420285-8	2007	UBE2D3 is physically associated with cyclin D1 and mediates ATRA-induced cyclin D1 degradation.	Tretinoin	60-64	cyclin D1	Homo sapiens	73-82
17420285-9	2007	Knocking down UBE2D3 by RNA interference (RNAi) leads to blockage of ATRA-induced cyclin D1 degradation and cell-cycle arrest.	Tretinoin	69-73	cyclin D1	Homo sapiens	82-91
17606477-3	2007	Administration of recombinant human IL-8 induced a rapid, time-dependent increase in cyclin D1 expression in AIPC cells, a response attenuated by the translation inhibitor cycloheximide but not by the RNA synthesis inhibitor, actinomycin D.	Cycloheximide	172-185	cyclin D1	Homo sapiens	85-94
17762392-7	2007	The synergistic effect was mediated through the same mechanism as in SK-7041 alone, involving reduction of cyclin D1 and induction of p21.	SK-7041	69-76	cyclin D1	Homo sapiens	107-116
17593037-9	2007	In this trial, HER-2 and CD1 proved of borderline significance as predictive factors for recurrence on tamoxifen.	Tamoxifen	103-112	cyclin D1	Homo sapiens	25-28
17370311-0	2007	PI-3K/Akt signal pathway plays a crucial role in arsenite-induced cell proliferation of human keratinocytes through induction of cyclin D1.	arsenite	49-57	cyclin D1	Homo sapiens	129-138
17370311-4	2007	Taken together, we provide the direct evidence that PI-3K/Akt pathway plays a role in the regulation of cell proliferation through the induction of cyclin D1 in human keratinocytes upon arsenite treatment.	arsenite	186-194	cyclin D1	Homo sapiens	148-157
17370311-5	2007	Given the importance of aberrant cell proliferation in cell transformation, we propose that the activation of PI-3K/Akt pathway and cyclin D1 induction may be the important mediators of human skin carcinogenic effect of arsenite.	arsenite	220-228	cyclin D1	Homo sapiens	132-141
17488338-8	2007	Although the stimulation with endothelin-1 plus calcium chloride increased cyclin D1 protein levels after 4-6 h, the level of phosphorylated retinoblastoma protein did not increase, suggesting that overexpression of cyclin D1 protein may have little effect on cell cycle progression but rather act as a pro-survival factor.	Calcium Chloride	48-64	cyclin D1	Homo sapiens	75-84
17488338-8	2007	Although the stimulation with endothelin-1 plus calcium chloride increased cyclin D1 protein levels after 4-6 h, the level of phosphorylated retinoblastoma protein did not increase, suggesting that overexpression of cyclin D1 protein may have little effect on cell cycle progression but rather act as a pro-survival factor.	Calcium Chloride	48-64	cyclin D1	Homo sapiens	216-225
17493827-2	2007	HIF-1 is essential for CoCl(2)+/-Y-27632-induced MSC neuronal differentiation, since agents inhibiting HIF-1 abolish the changes of morphology and cell cycle arrest-related gene or protein expressions (p21, cyclin D1) and the increase of neuronal marker expressions (Tuj1, NSE).	Y 27632	33-40	cyclin D1	Homo sapiens	207-216
17493827-3	2007	Y-27632 potentiates the CoCl(2)-induced decrease of cyclin D1 and nestin expressions, the increase of HIF-1 activation and EPO expression, and decreases pVHL expression.	Y 27632	0-7	cyclin D1	Homo sapiens	52-61
17493827-3	2007	Y-27632 potentiates the CoCl(2)-induced decrease of cyclin D1 and nestin expressions, the increase of HIF-1 activation and EPO expression, and decreases pVHL expression.	cobaltous chloride	24-31	cyclin D1	Homo sapiens	52-61
17382317-10	2007	Consistently with G(1) arrest, icaritin increased protein expressions of pRb, p27(Kip1) and p16(Ink4a), while showed decrease in phosphorylated pRb, Cyclin D1 and CDK4.	icaritin	31-39	cyclin D1	Homo sapiens	149-158
17475222-5	2007	Guggulsterone suppressed the proliferation of cells through inhibition of DNA synthesis, producing cell cycle arrest in S-phase, and this arrest correlated with a decrease in the levels of cyclin D1 and cdc2 and a concomitant increase in the levels of cyclin-dependent kinase inhibitor p21 and p27.	pregna-4,17-diene-3,16-dione	0-13	cyclin D1	Homo sapiens	189-198
17541034-0	2007	Suppression of pancreatic tumor growth by combination chemotherapy with sulindac and LC-1 is associated with cyclin D1 inhibition in vivo.	Sulindac	72-80	cyclin D1	Homo sapiens	109-118
17541034-10	2007	Cyclin D1 protein levels were reduced by the low-dose LC-1/sulindac combination or high-dose sulindac alone, correlating with BxPC-3 tumor suppression.	Sulindac	59-67	cyclin D1	Homo sapiens	0-9
17541034-10	2007	Cyclin D1 protein levels were reduced by the low-dose LC-1/sulindac combination or high-dose sulindac alone, correlating with BxPC-3 tumor suppression.	Sulindac	93-101	cyclin D1	Homo sapiens	0-9
17541034-11	2007	These results suggest that LC-1 and sulindac may mediate their antitumor effects, in part, by altering cyclin D1 levels.	Sulindac	36-44	cyclin D1	Homo sapiens	103-112
17575118-7	2007	We showed that CTFB-induced cell growth delay was accompanied by cell cycle arrest at the G(0)-G(1) phase that was associated with the up-regulation of p21/WAF1 and p27/Kip1 expression and the down-regulation of cyclin D1.	5-chloro-N-(2-(2-(4-chloro-phenyl)-3-methyl-butoxy)-5-trifluoromethyl-phenyl)-2-hydroxy-benzamide	15-19	cyclin D1	Homo sapiens	212-221
17197429-0	2007	Iron chelation regulates cyclin D1 expression via the proteasome: a link to iron deficiency-mediated growth suppression.	Iron	0-4	cyclin D1	Homo sapiens	25-34
17505005-8	2007	Capsaicin down-regulated the expression of the STAT3-regulated gene products, such as cyclin D1, Bcl-2, Bcl-xL, survivin, and vascular endothelial growth factor.	Capsaicin	0-9	cyclin D1	Homo sapiens	86-95
17457054-0	2007	Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells.	Apigenin	0-8	cyclin D1	Homo sapiens	92-101
17270149-5	2007	Celecoxib also suppressed the activity of TOPflash, T-cell factor reporter plasmid, and the reporter gene driven by the human cyclin D1 promoter, suggesting that this compound inhibited the expression of Wnt/beta-catenin signaling target genes.	Celecoxib	0-9	cyclin D1	Homo sapiens	126-135
17270149-7	2007	Moreover, NSAIDs (celecoxib, SC-560 and indomethacin) also suppressed the expression of cyclin D1 and survivin on other colon cancer cell lines (DLD-1 and SW-620).	Celecoxib	18-27	cyclin D1	Homo sapiens	88-97
17270149-7	2007	Moreover, NSAIDs (celecoxib, SC-560 and indomethacin) also suppressed the expression of cyclin D1 and survivin on other colon cancer cell lines (DLD-1 and SW-620).	SC 560	29-35	cyclin D1	Homo sapiens	88-97
17270149-7	2007	Moreover, NSAIDs (celecoxib, SC-560 and indomethacin) also suppressed the expression of cyclin D1 and survivin on other colon cancer cell lines (DLD-1 and SW-620).	Indomethacin	40-52	cyclin D1	Homo sapiens	88-97
17197429-0	2007	Iron chelation regulates cyclin D1 expression via the proteasome: a link to iron deficiency-mediated growth suppression.	Iron	76-80	cyclin D1	Homo sapiens	25-34
17197429-4	2007	Previously, we examined the effect of Fe depletion on the expression of cell-cycle control molecules and identified a marked decrease in cyclin D1 protein, although the mechanism involved was unknown.	Iron	38-40	cyclin D1	Homo sapiens	137-146
17197429-5	2007	In this study, we showed that cyclin D1 was regulated posttranscriptionally by Fe depletion.	Iron	79-81	cyclin D1	Homo sapiens	30-39
17197429-6	2007	Iron chelation of cells in culture using desferrioxamine (DFO) or 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone (311) decreased cyclin D1 protein levels after 14 hours and was rescued by the addition of Fe.	Iron	0-4	cyclin D1	Homo sapiens	135-144
17197429-6	2007	Iron chelation of cells in culture using desferrioxamine (DFO) or 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone (311) decreased cyclin D1 protein levels after 14 hours and was rescued by the addition of Fe.	Deferoxamine	41-56	cyclin D1	Homo sapiens	135-144
17197429-6	2007	Iron chelation of cells in culture using desferrioxamine (DFO) or 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone (311) decreased cyclin D1 protein levels after 14 hours and was rescued by the addition of Fe.	Deferoxamine	58-61	cyclin D1	Homo sapiens	135-144
17197429-6	2007	Iron chelation of cells in culture using desferrioxamine (DFO) or 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone (311) decreased cyclin D1 protein levels after 14 hours and was rescued by the addition of Fe.	2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone	66-118	cyclin D1	Homo sapiens	135-144
17197429-6	2007	Iron chelation of cells in culture using desferrioxamine (DFO) or 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone (311) decreased cyclin D1 protein levels after 14 hours and was rescued by the addition of Fe.	Iron	210-212	cyclin D1	Homo sapiens	135-144
17197429-9	2007	In Fe-replete cells, cyclin D1 was degraded in an ubiquitin-dependent manner, while Fe depletion induced a ubiquitin-independent pathway.	Iron	3-5	cyclin D1	Homo sapiens	21-30
17197429-10	2007	This is the first report linking Fe depletion-mediated growth suppression at G(1)/S to a mechanism inducing cyclin D1 proteolysis.	Iron	33-35	cyclin D1	Homo sapiens	108-117
17513611-7	2007	After 12 h of exposure to 1.0 micromol/L of lapatinib, AKT1, MAPK9, HSPCA, IRAK1, and CCND1 transcripts were down-regulated 7- to 25-fold in responsive BT474 and SKBr3 cells.	Lapatinib	44-53	cyclin D1	Homo sapiens	86-91
17473215-10	2007	The c-myc-induced cisplatin sensitivity correlated with inhibition of nuclear factor kappaB activity, which was partially restored by ectopic cyclin D1 overexpression.	Cisplatin	18-27	cyclin D1	Homo sapiens	142-151
17437483-3	2007	GSP-induced inhibition of cell proliferation was associated with an increase in G1-phase arrest at 24 h, which was mediated through the inhibition of cyclin-dependent kinases (Cdk) Cdk2, Cdk4, Cdk6 and cyclins D1, D2 and E and simultaneous increase in protein expression of cyclin-dependent kinase inhibitors (Cdki), Cip1/p21 and Kip1/p27, and enhanced binding of Cdki-Cdk.	Grape Seed Proanthocyanidins	0-3	cyclin D1	Homo sapiens	202-222
17007924-6	2007	Moreover, both LY294002 and rapamycin down-regulated the levels of c-Myc and cyclin D1 proteins in these cells, and their combination further decreased levels of these cell cycle-regulating proteins.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	cyclin D1	Homo sapiens	77-86
16963181-9	2007	Furthermore, rugosin E also inhibited the TNF-alpha-activated NF-kappaB-dependent reporter gene expression of cyclin D1, c-Myc, XIAP, Bcl-2, and Bcl-X(L) were all downregulated by rugosin E.	rugosin E	13-22	cyclin D1	Homo sapiens	110-119
16963181-9	2007	Furthermore, rugosin E also inhibited the TNF-alpha-activated NF-kappaB-dependent reporter gene expression of cyclin D1, c-Myc, XIAP, Bcl-2, and Bcl-X(L) were all downregulated by rugosin E.	rugosin E	180-189	cyclin D1	Homo sapiens	110-119
17217918-4	2007	The amlodipine-induced G1 arrest was associated with a decrease in phosphorylation of retinoblastoma protein (pRB), a regulator of G1 to S phase transition, reduction of protein levels of cyclin D1 and cyclin dependent kinase 4 (CDK4), G1 specific cell cycle proteins, and increased expression of p21(Waf1/Cip1), an inhibitory protein of CDK/cyclin complexes.	Amlodipine	4-14	cyclin D1	Homo sapiens	188-197
17440094-4	2007	Celecoxib induced p21(waf1/cip1) at the transcriptional level independent of wild-type p53 function, leading to decreased expression of cyclin D1 and hypophosphorylation of Rb, with subsequent marked downstream decreases in nuclear E2F-1 protein expression and E2F transactivating activity by luciferase reporter assay.	Celecoxib	0-9	cyclin D1	Homo sapiens	136-145
17440094-6	2007	Levels of p21(waf1/cip1) and cyclin D1 protein were reduced in the S phase compared with the G(1) and G(2) phases, suggesting a possible protective role for p21(waf1/cip1) expression in celecoxib toxicity.	Celecoxib	186-195	cyclin D1	Homo sapiens	29-38
17229588-9	2007	Therefore, increases of IAP1, IAP2, survivin, and cyclin D1 expressions and decreases of XIAP, caspase-3, and p21 expressions might partly contribute to the survival and proliferation of lung cancer cells after exposure to 2,4-DDE and COF.	2,4-decadienal	223-230	cyclin D1	Homo sapiens	50-59
17217918-5	2007	In vitro kinase assay revealed that amlodipine significantly decreased CDK2-, CDK4-, and their partners cyclin E- and cyclin D1-associated kinase activities.	Amlodipine	36-46	cyclin D1	Homo sapiens	118-127
17217918-6	2007	The amlodipine-induced reductions in cyclin D1 protein expression and in CDK2 kinase activity were reproduced by a dihydropyridine derivative, nicardipine, having an inhibitory effect on A431 cell growth, but not by nifedipine, lacking the antiproliferative activity.	Amlodipine	4-14	cyclin D1	Homo sapiens	37-46
17217918-6	2007	The amlodipine-induced reductions in cyclin D1 protein expression and in CDK2 kinase activity were reproduced by a dihydropyridine derivative, nicardipine, having an inhibitory effect on A431 cell growth, but not by nifedipine, lacking the antiproliferative activity.	1,4-dihydropyridine	115-130	cyclin D1	Homo sapiens	37-46
17217918-6	2007	The amlodipine-induced reductions in cyclin D1 protein expression and in CDK2 kinase activity were reproduced by a dihydropyridine derivative, nicardipine, having an inhibitory effect on A431 cell growth, but not by nifedipine, lacking the antiproliferative activity.	Nicardipine	143-154	cyclin D1	Homo sapiens	37-46
17449939-5	2007	We also found that the autocrine ERK activation was associated with the expression of cyclin D1 and the cell cycle regulation at the early stage of calcium triggering by treating the cells with the mitogen-activated protein kinase inhibitor PD98059.	Calcium	148-155	cyclin D1	Homo sapiens	86-95
17337101-6	2007	Immunoblot screening indicated that lycopene"s antiproliferative effects are likely achieved through a block in G1/S transition mediated by decreased levels of cyclins D1 and E and cyclin dependent kinase 4 and suppressed Retinoblastoma phosphorylation.	Lycopene	36-44	cyclin D1	Homo sapiens	160-176
17404108-0	2007	Menatetrenone, a vitamin K2 analogue, inhibits hepatocellular carcinoma cell growth by suppressing cyclin D1 expression through inhibition of nuclear factor kappaB activation.	menatetrenone	0-13	cyclin D1	Homo sapiens	99-108
17404108-5	2007	A reporter gene assay of the cyclin D1 promoter was done under vitamin K2 treatment.	Vitamin K 2	63-73	cyclin D1	Homo sapiens	29-38
17404108-8	2007	RESULTS: Vitamin K2 inhibited cyclin D1 mRNA and protein expression in a dose-dependent manner in the HCC cells.	Vitamin K 2	9-19	cyclin D1	Homo sapiens	30-39
17404108-9	2007	Vitamin K2 also suppressed the NF-kappaB binding site-dependent cyclin D1 promoter activity and suppressed the basal, 12-O-tetradecanoylphorbol-13-acetate (TPA)-, TNF-alpha-, and interleukin (IL)-1-induced activation of NF-kappaB binding and transactivation.	Vitamin K 2	0-10	cyclin D1	Homo sapiens	64-73
17404108-11	2007	Moreover, HCC cells overexpressing cyclin D1 and p65 became resistant to vitamin K2 treatment.	Vitamin K 2	73-83	cyclin D1	Homo sapiens	35-44
17404108-12	2007	CONCLUSION: Vitamin K2 inhibits the growth of HCC cells via suppression of cyclin D1 expression through the IKK/IkappaB/NF-kappaB pathway and might therefore be useful for treatment of HCC.	Vitamin K 2	12-22	cyclin D1	Homo sapiens	75-84
17449939-5	2007	We also found that the autocrine ERK activation was associated with the expression of cyclin D1 and the cell cycle regulation at the early stage of calcium triggering by treating the cells with the mitogen-activated protein kinase inhibitor PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	241-248	cyclin D1	Homo sapiens	86-95
17219422-10	2007	Retinol treatment decreased the transcription of a TOPFlash reporter construct and mRNA levels of the endogenous beta-catenin target genes, cyclin D1 and c-myc.	Vitamin A	0-7	cyclin D1	Homo sapiens	140-149
17431118-7	2007	In addition, dasatinib down-regulates expression of Stat5 target genes, including Bcl-x, Mcl-1, and cyclin D1.	Dasatinib	13-22	cyclin D1	Homo sapiens	100-109
17431121-9	2007	Cyclin D1 was not affected by RA, but this retinoid also increased CKI levels.	Retinoids	43-51	cyclin D1	Homo sapiens	0-9
17478933-6	2007	PD98059 could inhibit the cell proliferation mediated by HCV NS3 protein, down-regulate the activities of AP-1 and NF-kappaB, and suppress the expression of cyclin D1.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	cyclin D1	Homo sapiens	157-166
17363535-8	2007	RESULTS: Bexarotene-induced dosage-dependent repression of growth, cyclin D1, cyclin D3, total epidermal growth factor receptor (EGFR), and phospho-EGFR expression in BEAS-2B, BEAS-2B-R1, A427, and H358, but not H226 cells.	Bexarotene	9-19	cyclin D1	Homo sapiens	67-76
16964287-0	2007	Involvement of protein phosphatase 2A nuclear accumulation and subsequent inactivation of activator protein-1 in leptomycin B-inhibited cyclin D1 expression.	leptomycin B	113-125	cyclin D1	Homo sapiens	136-145
16964287-8	2007	Although phosphorylation of c-Jun at Ser-63 is required for activator protein 1 (AP-1)-dependent expression of cyclin D1, it decreased in LMB-treated cells compared to untreated cells.	Serine	37-40	cyclin D1	Homo sapiens	111-120
16964287-10	2007	We propose that inhibition of cyclin D1 expression by LMB is mediated by the LMB-induced nuclear accumulation of PP2A, leading to sustained dephosphorylation of c-Jun at Ser-63, which leads to inactivation of the transcription of the AP-1-responsive cyclin D1 gene.	Serine	170-173	cyclin D1	Homo sapiens	30-39
17332280-10	2007	In addition, the cyclopamine/siGli1-induced growth suppression was associated with the down-regulation of cyclins D1 and A and N-myc.	cyclopamine	17-28	cyclin D1	Homo sapiens	106-122
17327477-4	2007	Furthermore, leptin-induced cyclin D1 protein expression, which correlates well with HSC proliferation, was also significantly inhibited by leflunomide.	Leflunomide	140-151	cyclin D1	Homo sapiens	28-37
17050787-8	2007	Expressions of cyclin D1, E, and Cdk4 as well as cyclin D1/Cdk4 kinase activity were reduced by resveratrol only in LNCaP cells.	Resveratrol	96-107	cyclin D1	Homo sapiens	15-24
17050787-8	2007	Expressions of cyclin D1, E, and Cdk4 as well as cyclin D1/Cdk4 kinase activity were reduced by resveratrol only in LNCaP cells.	Resveratrol	96-107	cyclin D1	Homo sapiens	49-58
17605237-0	2007	[Analysis for the association between genetic polymorphisms of XRCC1, XPD, XRCC3, CCND1 and the latency of the occupational chronic benzene poisoning].	Benzene	132-139	cyclin D1	Homo sapiens	82-87
17605237-1	2007	OBJECTIVE: To explore the association between genetic polymorphisms of XRCC1, XPD, XRCC3 and CCND1 and latency of occupational chronic benzene poisoning.	Benzene	135-142	cyclin D1	Homo sapiens	93-98
17605237-7	2007	On the other hand, the latency developing chronic benzene poisoning was longer in workers with homozygous (CCND1 870A/A) or heterozygous (CCND1 870G/A) mutant alleles than in those carrying 870G/G homozygous wild genotype (14.9 vs. 8.7 years).	Benzene	50-57	cyclin D1	Homo sapiens	107-112
17605237-7	2007	On the other hand, the latency developing chronic benzene poisoning was longer in workers with homozygous (CCND1 870A/A) or heterozygous (CCND1 870G/A) mutant alleles than in those carrying 870G/G homozygous wild genotype (14.9 vs. 8.7 years).	Benzene	50-57	cyclin D1	Homo sapiens	138-143
17605237-8	2007	CONCLUSION: The polymorphisms of XRCC1 and CCND1 potentially modify the latency of the chronic benzene poisoning among workers exposed to benzene.	Benzene	95-102	cyclin D1	Homo sapiens	43-48
17605237-8	2007	CONCLUSION: The polymorphisms of XRCC1 and CCND1 potentially modify the latency of the chronic benzene poisoning among workers exposed to benzene.	Benzene	138-145	cyclin D1	Homo sapiens	43-48
17308274-0	2007	Cyclin D1 guanine/adenine 870 polymorphism with altered protein expression is associated with genomic instability and aggressive clinical biology of esophageal adenocarcinoma.	Guanine	10-17	cyclin D1	Homo sapiens	0-9
17308274-0	2007	Cyclin D1 guanine/adenine 870 polymorphism with altered protein expression is associated with genomic instability and aggressive clinical biology of esophageal adenocarcinoma.	Adenine	18-25	cyclin D1	Homo sapiens	0-9
17373752-8	2007	CONCLUSION: Our results support the hypothesis that cell cycle arrest induced by C2-ceramide may be mediated via accumulation of p21 and reduction of cyclinD1 and CDK7, at least partly, through PPARgamma activation.	N-acetylsphingosine	81-92	cyclin D1	Homo sapiens	150-158
17308107-5	2007	We also show that aspirin causes rapid, ubiquitin-dependent degradation of cyclin D1, a known p38 target.	Aspirin	18-25	cyclin D1	Homo sapiens	75-84
17308107-6	2007	Aspirin-induced p38 activation preceded cyclin D1 degradation, which was then followed by activation of the NF-kappaB pathway, suggesting a causative link.	Aspirin	0-7	cyclin D1	Homo sapiens	40-49
17308107-7	2007	Indeed, chemical p38 inhibition (PD169316) and small interfering RNA directed against p38 blocked aspirin-induced cyclin D1 degradation, nucleolar translocation of RelA, and apoptosis.	Aspirin	98-105	cyclin D1	Homo sapiens	114-123
17308107-8	2007	Furthermore, chemical inhibition of the cyclin D1/cyclin-dependent kinase 4 (CDK4) kinase complex, used as a surrogate for cyclin D1 degradation, caused nucleolar translocation of RelA, repression of kappaB-driven transcription, and apoptosis, thereby reproducing the effects of aspirin.	Aspirin	279-286	cyclin D1	Homo sapiens	40-75
17308107-8	2007	Furthermore, chemical inhibition of the cyclin D1/cyclin-dependent kinase 4 (CDK4) kinase complex, used as a surrogate for cyclin D1 degradation, caused nucleolar translocation of RelA, repression of kappaB-driven transcription, and apoptosis, thereby reproducing the effects of aspirin.	Aspirin	279-286	cyclin D1	Homo sapiens	40-49
17308107-10	2007	Collectively, these data suggest that aspirin causes inhibition of cyclin D1/CDK4 through the p38 MAPK pathway.	Aspirin	38-45	cyclin D1	Homo sapiens	67-76
17218782-10	2007	IC(50) dose (2.99 mM) of VPA was able to induce G(1) arrest (up to 75%) in association with upregulation of p16, p21 and cyclin-D1 related to Rb ipo-phosphorilation.	Valproic Acid	25-28	cyclin D1	Homo sapiens	121-130
17218782-10	2007	IC(50) dose (2.99 mM) of VPA was able to induce G(1) arrest (up to 75%) in association with upregulation of p16, p21 and cyclin-D1 related to Rb ipo-phosphorilation.	PARA-IODO-D-PHENYLALANINE HYDROXAMIC ACID	145-148	cyclin D1	Homo sapiens	121-130
16862172-8	2007	Immunoblot analysis showed that pretreatment of NHBE cells with EGCG resulted in a significant downregulation of NF-kappaB-regulated proteins cyclin D1, MMP-9, IL-8 and iNOS.	epigallocatechin gallate	64-68	cyclin D1	Homo sapiens	142-151
17138644-5	2007	Progestin induction of the cyclin D1 gene, which lacks a progesterone response element, was dependent on PR activation of the Src/MAPK pathway, whereas induction of the Sgk (serum and glucocorticoid regulated kinase) gene that contains a functional progesterone response element was unaffected by mutations that interfere with PR activation of Src.	Progesterone	57-69	cyclin D1	Homo sapiens	27-36
17297654-6	2007	The expression profiles of smad 4, cyclin D1 and p53 in the DMBA-induced tumors were similar to those of human pancreatic cancer, suggesting that this would be a useful mouse model for studying the morphological and molecular mechanisms involved in pancreatic carcinogenesis.	9,10-Dimethyl-1,2-benzanthracene	60-64	cyclin D1	Homo sapiens	35-44
17203214-2	2007	This study explores D-type cyclins as molecular targets in GCTs because all-trans-retinoic acid (RA)-mediated differentiation of the human embryonal carcinoma (EC) cell line NT2/D1 is associated with G1 cell cycle arrest and proteasomal degradation of cyclin D1.	Tretinoin	72-95	cyclin D1	Homo sapiens	252-261
17203214-2	2007	This study explores D-type cyclins as molecular targets in GCTs because all-trans-retinoic acid (RA)-mediated differentiation of the human embryonal carcinoma (EC) cell line NT2/D1 is associated with G1 cell cycle arrest and proteasomal degradation of cyclin D1.	Tretinoin	97-99	cyclin D1	Homo sapiens	252-261
17203214-8	2007	To confirm this, the EGFR-tyrosine kinase inhibitor, Erlotinib, was used to repress cyclin D1.	Erlotinib Hydrochloride	53-62	cyclin D1	Homo sapiens	84-93
17188682-4	2007	H2O2 downregulated cyclin D1; FGF-10 blocked these effects.	Hydrogen Peroxide	0-4	cyclin D1	Homo sapiens	19-28
17203177-7	2007	The results also showed that lycorine was able to block the cell cycle at the G0/G1 phase through the downregulation of both cyclin D1 and CDK4.	lycorine	29-37	cyclin D1	Homo sapiens	125-134
17159504-10	2007	15-Deoxy-Delta-prostaglandin J2+docetaxel showed a significant increase in apoptosis associated with inhibition of the Bcl2 and cyclin D1 expression and overexpression of caspase and p53 pathway genes.	15-deoxy-delta-prostaglandin j2	0-31	cyclin D1	Homo sapiens	128-137
17569210-6	2007	Curcumin arrested the cell cycle by preventing the expression of cyclin D1, cdk-1 and cdc-25.	Curcumin	0-8	cyclin D1	Homo sapiens	65-74
17159504-10	2007	15-Deoxy-Delta-prostaglandin J2+docetaxel showed a significant increase in apoptosis associated with inhibition of the Bcl2 and cyclin D1 expression and overexpression of caspase and p53 pathway genes.	Docetaxel	32-41	cyclin D1	Homo sapiens	128-137
17159504-11	2007	Further, enhanced expression of caspase 3 and inhibition of cyclin D1 by 15-deoxy-Delta-prostaglandin J2+docetaxel was not reversed by GW9662, thus suggesting a possible peroxisome proliferator-activated receptor-gamma-independent mechanism.	15-deoxy-delta-prostaglandin j2	73-104	cyclin D1	Homo sapiens	60-69
17159504-11	2007	Further, enhanced expression of caspase 3 and inhibition of cyclin D1 by 15-deoxy-Delta-prostaglandin J2+docetaxel was not reversed by GW9662, thus suggesting a possible peroxisome proliferator-activated receptor-gamma-independent mechanism.	Docetaxel	105-114	cyclin D1	Homo sapiens	60-69
17083567-7	2007	Treatment with cyclopamine induced not only G, arrest but also apoptosis along with the downregulation of cyclin A and cyclin D1, and the upregulation of p21 and p27.	cyclopamine	15-26	cyclin D1	Homo sapiens	119-128
17172818-5	2007	Sulindac sulfide induced expression of p21wafl/cipl in a dose-dependent fashion, decreased cyclin D1 protein levels, and increased Rb hypophosphorylation.	sulindac sulfide	0-16	cyclin D1	Homo sapiens	91-100
16920736-5	2007	We further found that PFE treatment also resulted in (i) induction of WAF1/p21 and KIP1/p27, (ii) decrease in the protein expressions of cyclins D1, D2 and E, and (iii) decrease in cyclin-dependent kinase (cdk) 2, cdk4 and cdk6 expression.	Coconut Oil	22-25	cyclin D1	Homo sapiens	137-157
17161815-4	2007	PD98059 also decreased the Cdk-2, Cdk-4, cyclin D1, and cyclin E expression, and increased high levels of the mitotic inhibitors p16(INIa), p21(Waf1), and p27(Kip1).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	cyclin D1	Homo sapiens	41-50
17210710-7	2007	Critical components in the translational machinery, such as phosphorylated mammalian target of rapamycin (mTOR) and its downstream targets, phosphorylated eukaryotic translation initiation factor and p70 S6 kinase, were up-regulated following NO treatment, and inhibition of mTOR with rapamycin attenuated NO induced increase of cyclin D1 and ODC.	Sirolimus	95-104	cyclin D1	Homo sapiens	329-338
17143483-7	2007	Moreover, GA treatment led to reduced expression of the Wnt signaling target and cell cycle-promoting gene cyclin D1, providing a potential mechanism for the reduced proliferation.	geldanamycin	10-12	cyclin D1	Homo sapiens	107-116
17407970-9	2007	Nevertheless Dip1 markedly inhibited the stimulation of cyclin D1 promoter activity obtained with trichostatin A [1], an inhibitor of HDAC.	trichostatin A	98-112	cyclin D1	Homo sapiens	56-65
17726044-9	2007	Our studies provide a mechanistic insight into the regulation of tumor suppressor protein SMAR1 by a cancer therapeutic PGA2, that leads to repression of Cyclin D1 gene.	prostaglandin A2	120-124	cyclin D1	Homo sapiens	154-163
17640162-9	2007	The expressions of cyclin D1, estrogen receptor alpha, human epidermal growth factor receptor 2, and insulin-like growth factor I receptor in the TAM group were significantly reduced when TAM was combined with 5FS or 10FS.	Tamoxifen	146-149	cyclin D1	Homo sapiens	19-28
17640162-9	2007	The expressions of cyclin D1, estrogen receptor alpha, human epidermal growth factor receptor 2, and insulin-like growth factor I receptor in the TAM group were significantly reduced when TAM was combined with 5FS or 10FS.	Tamoxifen	188-191	cyclin D1	Homo sapiens	19-28
17143939-10	2006	Troglitazone increased expression of p21(WAF1/CIP1) (p21), p27(KIP1) (p27) and reduced cyclin D1 in HCT-116 cells while only a minor decrease of cyclin D1 was found in HCT-15 cells.	Troglitazone	0-12	cyclin D1	Homo sapiens	87-96
17178882-4	2006	Sorafenib inhibited the phosphorylation of MEK and ERK and down-regulated cyclin D1 levels in these two cell lines.	Sorafenib	0-9	cyclin D1	Homo sapiens	74-83
17122440-6	2006	Transfection of dnTCF-4 in the ISS10 human VSMC line significantly lowered TCF and cyclin D1 reporter activity but significantly elevated p21 reporter activity, indicating regulation of these genes by beta-catenin/TCF signaling.	dntcf	16-21	cyclin D1	Homo sapiens	83-92
17374178-10	2007	Inhibition of ERKs activation by AG126, AP-1 by curcumin, and JNKs by SP600125 could reduced the induction of cyclin D1 and CDK4, whereas inhibition of p38K by SB203580 did not show any inhibitory effects on S-HELF.	Curcumin	48-56	cyclin D1	Homo sapiens	110-119
17374178-10	2007	Inhibition of ERKs activation by AG126, AP-1 by curcumin, and JNKs by SP600125 could reduced the induction of cyclin D1 and CDK4, whereas inhibition of p38K by SB203580 did not show any inhibitory effects on S-HELF.	pyrazolanthrone	70-78	cyclin D1	Homo sapiens	110-119
17268643-0	2006	Synthesis, crystal structure and biological activity of beta-carboline based selective CDK4-cyclin D1 inhibitors.	norharman	56-70	cyclin D1	Homo sapiens	92-101
17046823-8	2006	Further, we found that not only GSK-3beta but also DYRK1B modulates cyclin D1 subcellular localization by the phosphorylation of Thr(288).	Threonine	129-132	cyclin D1	Homo sapiens	68-77
17046823-9	2006	These results suggest that DIF-3 induces degradation of cyclin D1 through the GSK-3beta- and DYRK1B-mediated threonine phosphorylation in HeLa cells.	Threonine	109-118	cyclin D1	Homo sapiens	56-65
16829689-0	2006	The effect of the cyclin D1 (CCND1) A870G polymorphism on colorectal cancer risk is modified by glutathione-S-transferase polymorphisms and isothiocyanate intake in the Singapore Chinese Health Study.	isothiocyanic acid	140-154	cyclin D1	Homo sapiens	18-27
17166371-13	2006	CONCLUSION: 9-Cis RA could induce G1 phase arrest and apoptosis in MGC803 cells through down-regulating the expression of cell cycle factors Cyclin D1 and CDK4.	Radium	18-20	cyclin D1	Homo sapiens	141-150
16829689-0	2006	The effect of the cyclin D1 (CCND1) A870G polymorphism on colorectal cancer risk is modified by glutathione-S-transferase polymorphisms and isothiocyanate intake in the Singapore Chinese Health Study.	isothiocyanic acid	140-154	cyclin D1	Homo sapiens	29-34
17157164-7	2006	At the molecular level, 17-AAG induced degradation of ALK and Akt proteins, dephosphorylated extracellular signal-regulated kinase, and degraded the cell-cycle regulatory protein cyclin D1 and its cyclin-dependent kinases, CDK4 and CDK6, but had a differential effect on p27 and p53 proteins.	tanespimycin	24-30	cyclin D1	Homo sapiens	179-188
17145894-7	2006	Adiponectin-mediated suppression of cyclin D1 expression and attenuation of cell proliferation was abrogated by the GSK-3beta inhibitor lithium chloride.	Lithium Chloride	136-152	cyclin D1	Homo sapiens	36-45
17145896-0	2006	Cyclin D1 is necessary for tamoxifen-induced cell cycle progression in human breast cancer cells.	Tamoxifen	27-36	cyclin D1	Homo sapiens	0-9
17145896-3	2006	Here, we investigate the role of cyclin D1, a mediator of estrogen-dependent proliferation, in growth of tamoxifen-resistant cells using a cell culture model of acquired resistance to tamoxifen.	Tamoxifen	105-114	cyclin D1	Homo sapiens	33-42
17145896-3	2006	Here, we investigate the role of cyclin D1, a mediator of estrogen-dependent proliferation, in growth of tamoxifen-resistant cells using a cell culture model of acquired resistance to tamoxifen.	Tamoxifen	184-193	cyclin D1	Homo sapiens	33-42
17145896-5	2006	Down-regulation of cyclin D1 with small interfering RNA blocked basal cell growth of tamoxifen-resistant cells and induction of cell proliferation by OHT.	Tamoxifen	85-94	cyclin D1	Homo sapiens	19-28
17145896-7	2006	These findings indicate that cyclin D1 expression is necessary for proliferation of tamoxifen-resistant cells and for tamoxifen-induced cell cycle progression.	Tamoxifen	84-93	cyclin D1	Homo sapiens	29-38
17145896-7	2006	These findings indicate that cyclin D1 expression is necessary for proliferation of tamoxifen-resistant cells and for tamoxifen-induced cell cycle progression.	Tamoxifen	118-127	cyclin D1	Homo sapiens	29-38
17145896-8	2006	These results suggest that therapeutic strategies to block cyclin D1 expression or function may inhibit development and growth of tamoxifen-resistant tumors.	Tamoxifen	130-139	cyclin D1	Homo sapiens	59-68
17088977-5	2006	Therefore, Bcl-2 and cyclin D1 were chosen as putative targets for increasing cell death and growth arrest induced by cisplatin, thereby enhancing the drug sensitivity in MCF-7.	Cisplatin	118-127	cyclin D1	Homo sapiens	21-30
17348201-6	2006	At the same time,the phosphorylation of Src kinase and ERK-1/2 was enhanced after treated with l microg/ml of o-HA at 5 min and the expression of cyclin D1 was enhanced by treating PIEC cells with o-HA at 3 hr.	Oligosaccharides	110-114	cyclin D1	Homo sapiens	146-155
17348201-6	2006	At the same time,the phosphorylation of Src kinase and ERK-1/2 was enhanced after treated with l microg/ml of o-HA at 5 min and the expression of cyclin D1 was enhanced by treating PIEC cells with o-HA at 3 hr.	Oligosaccharides	197-201	cyclin D1	Homo sapiens	146-155
17088977-0	2006	Enhancing cisplatin sensitivity in MCF-7 human breast cancer cells by down-regulation of Bcl-2 and cyclin D1.	Cisplatin	10-19	cyclin D1	Homo sapiens	99-108
17088977-4	2006	After cisplatin treatment a decrease in cyclin D1 was seen in all the breast cancer cells studied.	Cisplatin	6-15	cyclin D1	Homo sapiens	40-49
17089025-13	2006	p27(KIP1) phosphorylation and cyclin D1 induction were inhibited by PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	68-75	cyclin D1	Homo sapiens	30-39
16959222-8	2006	Finally, curcumin treatment inhibited Jak2 mRNA expression as well as cyclin D1 and v-src gene expression in K562 chronic leukaemia cells.	Curcumin	9-17	cyclin D1	Homo sapiens	70-79
17121904-5	2006	RESULTS: In this study, we showed that the combination of rapamycin and 17-AAG synergistically inhibited proliferation, induced apoptosis and cell cycle arrest, induced cleavage of poly(ADP-ribose) polymerase and caspase-8/caspase-9, and dysregulated signaling in the phosphatidylinositol 3-kinase/AKT/mTOR and cyclin D1/retinoblastoma pathways.	Sirolimus	58-67	cyclin D1	Homo sapiens	311-320
17121904-5	2006	RESULTS: In this study, we showed that the combination of rapamycin and 17-AAG synergistically inhibited proliferation, induced apoptosis and cell cycle arrest, induced cleavage of poly(ADP-ribose) polymerase and caspase-8/caspase-9, and dysregulated signaling in the phosphatidylinositol 3-kinase/AKT/mTOR and cyclin D1/retinoblastoma pathways.	tanespimycin	72-78	cyclin D1	Homo sapiens	311-320
16917105-0	2006	Inhibition of smooth muscle proliferation by urea-based alkanoic acids via peroxisome proliferator-activated receptor alpha-dependent repression of cyclin D1.	urea-based alkanoic acids	45-70	cyclin D1	Homo sapiens	148-157
17178895-6	2006	Furthermore, we show that Ron overexpression leads to receptor phosphorylation and is associated with elevated levels of tyrosine phosphorylated beta-catenin and the up-regulation of genes, including cyclin D1 and c-myc, which are associated with poor prognosis in patients with human breast cancers.	Tyrosine	121-129	cyclin D1	Homo sapiens	200-209
16959960-7	2006	In addition, the combination of sorafenib and rottlerin reduced or completely inhibited the phosphorylation of extracellular signal-regulated kinase and Akt and down-regulated cell cycle regulatory proteins such as cyclin-D1, cyclin-D3, cyclin-dependent kinase (cdk)4, and cdk6 in a dose- and time-dependent manner.	Sorafenib	32-41	cyclin D1	Homo sapiens	215-224
16959960-7	2006	In addition, the combination of sorafenib and rottlerin reduced or completely inhibited the phosphorylation of extracellular signal-regulated kinase and Akt and down-regulated cell cycle regulatory proteins such as cyclin-D1, cyclin-D3, cyclin-dependent kinase (cdk)4, and cdk6 in a dose- and time-dependent manner.	rottlerin	46-55	cyclin D1	Homo sapiens	215-224
17005224-0	2006	Induction of cyclin D1 by submicromolar concentrations of arsenite in human epidermal keratinocytes.	arsenite	58-66	cyclin D1	Homo sapiens	13-22
17005224-2	2006	To gain insight into the oncogenic properties of arsenic, we studied the expression of cyclin D1 in cultured human epidermal keratinocytes treated with submicromolar concentrations of sodium arsenite.	sodium arsenite	184-199	cyclin D1	Homo sapiens	87-96
17005224-6	2006	Real-time PCR analysis of cyclin D1 transcription showed that there was an induction of more than three-fold in cells exposed to 400 nM arsenite for 3 days.	arsenite	136-144	cyclin D1	Homo sapiens	26-35
17088977-6	2006	RNA interference, using Bcl-2- and cyclin D1- siRNAs sensitized MCF-7 cells to cisplatin treatment and by simultaneous knockdown of both Bcl-2 and cyclin D1 further sensitization was seen.	Cisplatin	79-88	cyclin D1	Homo sapiens	35-44
16841329-4	2006	beta-Cryptoxanthin suppressed the protein levels of cyclin D1 and cyclin E, up-regulated the cell cycle inhibitor p21, increased the number of lung cancer cells in the G1/G0 phase and decreased those in the S phase of the cell cycle.	Beta-Cryptoxanthin	0-18	cyclin D1	Homo sapiens	52-61
16542821-6	2006	In addition, similar to LY294002, CZP arrested cell cycle progression at G0/G1 phase, which was accompanied by decreased expression of cyclin D1.	Clozapine	34-37	cyclin D1	Homo sapiens	135-144
16542821-7	2006	The reduction in the cyclin D1 level induced by CZP was abrogated by the inhibition of GSK-3beta, the inhibition of proteasome-dependent proteolysis, or an increase in the intracellular Ca(2+) concentration.	Clozapine	48-51	cyclin D1	Homo sapiens	21-30
16624404-2	2006	Due to the important functional interaction between cyclin D1 and cyclin dependent kinases, cyclin dependent kinase inhibitors such as flavopiridol are under consideration for treatment of patients with MCL.	alvocidib	135-147	cyclin D1	Homo sapiens	52-61
17290739-0	2006	[Study on E-cadherin, Cyclin D1 and Cyclin E expression in anti-malignant transformation by chlorophyllin].	chlorophyllin	92-105	cyclin D1	Homo sapiens	22-31
17290739-5	2006	Cyclin D1 and Cyclin E had no expression in control 16HBE, but expressions of the proteins were enhanced obviously in malignant transformed cell line while those were inhibited significantly in the anti-transformed cells treated with 100pmol/L chlorophyllin.	chlorophyllin	244-257	cyclin D1	Homo sapiens	0-9
17331354-0	2006	[In vitro gene silencing by siRNA of cyclin D1 on tongue squamous cell carcinoma cell line resistant to cisplatin].	Cisplatin	104-113	cyclin D1	Homo sapiens	37-46
17331354-5	2006	The changes of cisplatin sensitivity after treatment with siRNA cyclin D1 were examined with methyl thiazolyl tetrazolium (MTT) assay.	Cisplatin	15-24	cyclin D1	Homo sapiens	64-73
17331354-5	2006	The changes of cisplatin sensitivity after treatment with siRNA cyclin D1 were examined with methyl thiazolyl tetrazolium (MTT) assay.	methyl thiazolyl tetrazolium	93-121	cyclin D1	Homo sapiens	64-73
17331354-5	2006	The changes of cisplatin sensitivity after treatment with siRNA cyclin D1 were examined with methyl thiazolyl tetrazolium (MTT) assay.	monooxyethylene trimethylolpropane tristearate	123-126	cyclin D1	Homo sapiens	64-73
17331354-10	2006	CONCLUSIONS: Chemical synthesized cyclin D1 siRNA effectively silenced the expression of cyclin D1 gene in Tca8113-CDDP cells in vitro, with a time- and dose-dependent manner and target gene silence in cells increased its sensitivity to cisplatin.	Cisplatin	237-246	cyclin D1	Homo sapiens	34-43
17331354-10	2006	CONCLUSIONS: Chemical synthesized cyclin D1 siRNA effectively silenced the expression of cyclin D1 gene in Tca8113-CDDP cells in vitro, with a time- and dose-dependent manner and target gene silence in cells increased its sensitivity to cisplatin.	Cisplatin	237-246	cyclin D1	Homo sapiens	89-98
17200689-6	2006	IGF-1 increases the cyclic AMP-responsive element (CRE) binding transcription factor CREB phosphorylation at Ser 133 and CRE-binding activity in mesangial cells, which parallels cyclin D1 and fibronectin expressions.	Cyclic AMP	20-30	cyclin D1	Homo sapiens	178-187
17200689-6	2006	IGF-1 increases the cyclic AMP-responsive element (CRE) binding transcription factor CREB phosphorylation at Ser 133 and CRE-binding activity in mesangial cells, which parallels cyclin D1 and fibronectin expressions.	Serine	109-112	cyclin D1	Homo sapiens	178-187
17200689-8	2006	Suppression of GSK-3beta by SB216763 (100 nM) increases CREB phosphorylation, cyclin D1 and fibronectin levels.	SB 216763	28-36	cyclin D1	Homo sapiens	78-87
17011980-5	2006	After digestion with MspI, common CCND1 polymorphic alleles were analyzed by means of agarose gel electrophoresis.	Sepharose	86-93	cyclin D1	Homo sapiens	34-39
17011984-6	2006	In addition, the cDNA arrays detected two apparently single-gene amplicons, at 11q13 (CCND1) and 12p12.1 (K-RAS), the presence of which were confirmed using oligonucleotide arrays.	Oligonucleotides	157-172	cyclin D1	Homo sapiens	86-91
17015746-6	2006	The effect of SAA on FLS hyperplasia was shown to be caused by an increase in the levels of intracellular calcium, as well as the activation of ERK and Akt, which resulted in an elevation in the expression of cyclin D1 and Bcl-2.	Calcium	106-113	cyclin D1	Homo sapiens	209-218
17047061-11	2006	Cyclin D1 regulated p27(KIP1) abundance at the posttranslational level, inhibiting the Skp2 promoter, Skp2 abundance, and induced p27(KIP1) phosphorylation at Ser(10).	Serine	159-162	cyclin D1	Homo sapiens	0-9
16702957-0	2006	Tristetraprolin regulates Cyclin D1 and c-Myc mRNA stability in response to rapamycin in an Akt-dependent manner via p38 MAPK signaling.	Sirolimus	76-85	cyclin D1	Homo sapiens	26-35
16732330-3	2006	Cyclin D1 nuclear export depends upon phosphorylation of a C-terminal residue, threonine 286, (Thr-286) which in turn promotes association with the nuclear exportin, CRM1.	Threonine	79-88	cyclin D1	Homo sapiens	0-9
16732330-3	2006	Cyclin D1 nuclear export depends upon phosphorylation of a C-terminal residue, threonine 286, (Thr-286) which in turn promotes association with the nuclear exportin, CRM1.	Threonine	95-98	cyclin D1	Homo sapiens	0-9
16732330-4	2006	Mutation of Thr-286 to a non-phosphorylatable residue results in a constitutively nuclear cyclin D1 protein with significantly increased oncogenic potential.	Threonine	12-15	cyclin D1	Homo sapiens	90-99
16732330-7	2006	The mutations identified specifically disrupt phosphorylation of cyclin D1 at Thr-286, thereby enforcing nuclear accumulation of cyclin D1.	Threonine	78-81	cyclin D1	Homo sapiens	65-74
16732330-7	2006	The mutations identified specifically disrupt phosphorylation of cyclin D1 at Thr-286, thereby enforcing nuclear accumulation of cyclin D1.	Threonine	78-81	cyclin D1	Homo sapiens	129-138
16927018-8	2006	However, introduced cyclin D1 into Jurkat T tetracycline (Tet)-On cell system still couldn"t rescue cells from apoptosis.	t tetracycline	42-56	cyclin D1	Homo sapiens	20-29
16927018-8	2006	However, introduced cyclin D1 into Jurkat T tetracycline (Tet)-On cell system still couldn"t rescue cells from apoptosis.	Tetracycline	58-61	cyclin D1	Homo sapiens	20-29
16967051-7	2006	The impaired anti-mitogenic action of dexamethasone was associated with a failure to reduce the levels of the rate-limiting cell cycle regulatory protein, cyclin D1.	Dexamethasone	38-51	cyclin D1	Homo sapiens	155-164
16967051-8	2006	When signalling through the alpha2beta1 integrin was reduced, dexamethasone-mediated reductions in proliferation and cyclin D1 levels were restored.	Dexamethasone	62-75	cyclin D1	Homo sapiens	117-126
16621886-4	2006	Our western blot analysis showed that berberine-induced G(1) cell cycle arrest was mediated through the increased expression of Cdki proteins (Cip1/p21 and Kip1/p27), a simultaneous decrease in Cdk2, Cdk4, Cdk6 and cyclins D1, D2 and E and enhanced binding of Cdki-Cdk.	Berberine	38-47	cyclin D1	Homo sapiens	215-235
16741950-4	2006	Here, we demonstrate that extracellular ATP has a mitogenic effect on ARO cells, increasing ERK phosphorylation, AP1 activation, and cyclin D1 expression.	Adenosine Triphosphate	40-43	cyclin D1	Homo sapiens	133-142
17041101-7	2006	Analysis of the effects of the analogues on the expression of cancer-related genes usually affected by curcumin indicated that some induced the down-regulation of beta-catenin, Ki-ras, cyclin D1, c-Myc, and ErbB-2 at as low as one eighth the concentration at which curcumin normally has an effect.	Curcumin	103-111	cyclin D1	Homo sapiens	185-194
17041101-7	2006	Analysis of the effects of the analogues on the expression of cancer-related genes usually affected by curcumin indicated that some induced the down-regulation of beta-catenin, Ki-ras, cyclin D1, c-Myc, and ErbB-2 at as low as one eighth the concentration at which curcumin normally has an effect.	Curcumin	265-273	cyclin D1	Homo sapiens	185-194
16839579-0	2006	Nuclear type II [3H]estradiol binding site ligands: inhibition of ER-positive and ER-negative cell proliferation and c-Myc and cyclin D1 gene expression.	Tritium	17-19	cyclin D1	Homo sapiens	127-136
16839579-8	2006	Both ZN-1 and ZN-2 blocked estradiol stimulation of c-Myc and cyclin D1 gene expression in MCF-7 cells, two events that are clearly coupled to cell cycle progression.	zn-1	5-9	cyclin D1	Homo sapiens	62-71
16839579-8	2006	Both ZN-1 and ZN-2 blocked estradiol stimulation of c-Myc and cyclin D1 gene expression in MCF-7 cells, two events that are clearly coupled to cell cycle progression.	Zinc	14-18	cyclin D1	Homo sapiens	62-71
16839579-8	2006	Both ZN-1 and ZN-2 blocked estradiol stimulation of c-Myc and cyclin D1 gene expression in MCF-7 cells, two events that are clearly coupled to cell cycle progression.	Estradiol	27-36	cyclin D1	Homo sapiens	62-71
16980581-4	2006	Here, we show that estradiol (E2) stimulation of CCND1 expression in BCC depends on a novel cell-type-specific enhancer downstream from the CCND1 coding region, which is the primary ERalpha recruitment site in estrogen-responsive cells.	Estradiol	19-28	cyclin D1	Homo sapiens	49-54
16777971-6	2006	Rosiglitazone-induced growth inhibition was associated with cell cycle arrest and changes in cell cycle regulators, such as an increase of cyclin-dependent kinases inhibitors p21(cip1) and p27(kip1), a decrease of cyclin D1, and inactivation of Rb protein.	Rosiglitazone	0-13	cyclin D1	Homo sapiens	214-223
16849370-5	2006	Utilizing MCF-7 Tet-Off breast cancer cell lines stably expressing two different nuclear localization defective PTEN mutants, as well as wild-type PTEN and empty vector control cells, we demonstrate that nuclear PTEN down-regulates cyclin D1 transcription and this event is mediated by the down-regulation of MAPK specifically by nuclear localized PTEN.	tetramethylenedisulfotetramine	16-19	cyclin D1	Homo sapiens	232-241
16985067-3	2006	DIM-C-pPhtBu induces PPARgamma-independent down-regulation of cyclin D1 and we therefore further investigated activation of receptor-independent pathways.	1,1-bis(3'-indolyl)-1-(4-t-butylphenyl)methane	0-12	cyclin D1	Homo sapiens	62-71
16942622-3	2006	We recently showed that phosphorylation of Thr-286 is responsible for a decline in cyclin D1 levels during S phase, an event required for efficient DNA synthesis.	Threonine	43-46	cyclin D1	Homo sapiens	83-92
16937493-8	2006	FCM analysis showed that the ratio of G0/G1 phase cells increased, S phase ratio decreased and apoptosis rate increased after SW480 cells were exposed to CAPE for 24 h. Pretreatment of SW480 cells with CAPE significantly suppressed beta-catenin, c-myc and cyclinD1 protein expression.	caffeic acid phenethyl ester	154-158	cyclin D1	Homo sapiens	256-264
16937493-8	2006	FCM analysis showed that the ratio of G0/G1 phase cells increased, S phase ratio decreased and apoptosis rate increased after SW480 cells were exposed to CAPE for 24 h. Pretreatment of SW480 cells with CAPE significantly suppressed beta-catenin, c-myc and cyclinD1 protein expression.	caffeic acid phenethyl ester	202-206	cyclin D1	Homo sapiens	256-264
16794187-4	2006	Consistent with the cell-cycle effects, at a molecular level (Western blots), 2-ME inhibited cyclin D(1) and cyclin B(1) expression; cyclin-dependent kinase (cdk)-1 and cdk-2 activity; and retinoblastoma protein (pRb), extracellular signal-regulated kinase (ERK) 1/2, and Akt phosphorylation.	2-Methoxyestradiol	78-82	cyclin D1	Homo sapiens	93-104
16965676-10	2006	Carbamazepine treatment could decrease the expression of ERalpha and Cyclin D1 at protein and mRNA level in ERalpha-positive cells and could reduce HER-2 expression in MCF-7RT cells.	Carbamazepine	0-13	cyclin D1	Homo sapiens	69-78
16965676-11	2006	The decrease of ERalpha and Cyclin D1 expression was inhibited by MG132, an inhibitor of 26S proteosome.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	66-71	cyclin D1	Homo sapiens	28-37
16965676-13	2006	CONCLUSIONS: Carbamazepine shows significant anti-proliferation effect in ERalpha-positive breast cancer cell lines and this might be due to the enhancement of proteosome-mediated degradation of ERalpha and Cyclin D1 by carbamazepine.	Carbamazepine	13-26	cyclin D1	Homo sapiens	207-216
16965676-13	2006	CONCLUSIONS: Carbamazepine shows significant anti-proliferation effect in ERalpha-positive breast cancer cell lines and this might be due to the enhancement of proteosome-mediated degradation of ERalpha and Cyclin D1 by carbamazepine.	Carbamazepine	220-233	cyclin D1	Homo sapiens	207-216
16289073-6	2006	In addition, RANTES and MCP-1 upregulated cyclin D1 in the presence of pitavastatin.	pitavastatin	71-83	cyclin D1	Homo sapiens	42-51
16861913-9	2006	As a result, trastuzumab inhibited Rb phosphorylation that associates with CDK2, cyclin E, CDK6, cyclin A, or cyclin D1.	Rubidium	35-37	cyclin D1	Homo sapiens	110-119
16885382-2	2006	Androgen [5alpha-dihydrotestosterone (DHT)] stimulation of LNCaP prostate cancer cells, which have constitutive phosphatidylinositol 3-kinase (PI3K)/Akt pathway activation due to PTEN loss, caused increased expression of cyclin D1, D2, and D3 proteins, retinoblastoma protein hyperphosphorylation, and cell cycle progression.	Dihydrotestosterone	10-36	cyclin D1	Homo sapiens	221-230
16895542-10	2006	Western blot analysis demonstrated that the protein level of phosphorylated beta-catenin increased, whereas that of cyclin D1 decreased, after treatment of MSC with aspirin.	Aspirin	165-172	cyclin D1	Homo sapiens	116-125
16496386-8	2006	Inhibition of Ras by farnesyl thiosalicylic acid promoted proteasomal degradation of cyclin D1, with a concomitant decrease in phosphorylated retinoblastoma protein accompanied by downregulation of E2F1 and decreased expression of key E2F1-regulated genes critical for cell-cycle progression.	farnesylthiosalicylic acid	21-48	cyclin D1	Homo sapiens	85-94
16637063-10	2006	5GG treatment also led to a dose-dependent decrease in the expression of the estrogen-activated cyclin D1 expression.	pentagalloylglucose	0-3	cyclin D1	Homo sapiens	96-105
16652374-7	2006	In addition, cyclin D1, which is considered as an AP-1 target gene and promotes cell proliferation, was markedly elevated in PEITC-treated cells.	phenethyl isothiocyanate	125-130	cyclin D1	Homo sapiens	13-22
16885564-7	2006	Interestingly, Fhit down-modulation of phosphatase activity of calcineurin, which controls cyclin D1/Cdk4 activation, was reversed by cyclophilin A treatment in a concentration-dependent manner, a reversal that was inhibited by additional cyclosporine A treatment.	Cyclosporine	239-253	cyclin D1	Homo sapiens	91-100
16928827-6	2006	In both azoxymethane-treated rats and HT-29 cells treated with 5% PEG-3350 for 24 hours, PEG decreased proliferation (45% and 52%, respectively) and cyclin D1 (78% and 56%, respectively).	Polyethylene Glycols	66-69	cyclin D1	Homo sapiens	149-158
16928827-6	2006	In both azoxymethane-treated rats and HT-29 cells treated with 5% PEG-3350 for 24 hours, PEG decreased proliferation (45% and 52%, respectively) and cyclin D1 (78% and 56%, respectively).	Polyethylene Glycols	89-92	cyclin D1	Homo sapiens	149-158
16518410-7	2006	The inhibitor of PI3-K, Wortmannin, and anti-alpha5beta1 integrin antibodies abrogated the effect of fibronectin on c-Myc, cyclin D1, p21, and PTEN expression.	Wortmannin	24-34	cyclin D1	Homo sapiens	123-132
16157446-4	2006	EGCG inhibited cell proliferation induced by oncogenic Ras and blocked cell cycle transition at G1 phase via inhibition of cyclin D1 expression.	epigallocatechin gallate	0-4	cyclin D1	Homo sapiens	123-132
16917105-5	2006	Furthermore, the alkanoic acids attenuated platelet-derived growth factor-induced smooth muscle cell proliferation via repression of cyclin D1 expression.	alkanoic acids	17-31	cyclin D1	Homo sapiens	133-142
16954476-0	2006	Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model.	Bortezomib	41-51	cyclin D1	Homo sapiens	0-9
16954476-4	2006	Cyclin D1 protein was stabilized by treatment with the proteasome inhibitor bortezomib, and the effects on STAT3 expression in vitro was determined by using immunoblotting and on xenograft tumor growth and apoptosis in vivo was determined by using terminal deoxyuridine nick-end labeling assays.	Bortezomib	76-86	cyclin D1	Homo sapiens	0-9
16954476-4	2006	Cyclin D1 protein was stabilized by treatment with the proteasome inhibitor bortezomib, and the effects on STAT3 expression in vitro was determined by using immunoblotting and on xenograft tumor growth and apoptosis in vivo was determined by using terminal deoxyuridine nick-end labeling assays.	Deoxyuridine	257-269	cyclin D1	Homo sapiens	0-9
16954476-10	2006	In addition, bortezomib can amplify the proapoptotic function of cyclin D1, raising the possibility that cyclin D1 levels may be a marker for predicting the response to this novel drug.	Bortezomib	13-23	cyclin D1	Homo sapiens	65-74
17094491-9	2006	Furthermore, (-)-gossypol treatment down-regulated cyclin-D1, Rb, CDK4 and CDK6, and up-regulated p21 and TGF-beta1 at the mRNA and/or protein levels.	Gossypol	13-25	cyclin D1	Homo sapiens	51-60
16690963-4	2006	Cell lines and tissue samples displayed constitutive activation of the cyclin D1 signaling cascade, as evidenced by strong expression of CDK4, Rb phosphorylation, and cyclin D1/CDK4 coassociation.	Rubidium	143-145	cyclin D1	Homo sapiens	71-80
16985035-10	2006	CONCLUSION: Our study indicates that TMA can be used to reliably assess the expression levels of Ki-67, cyclin D1, beta-catenin, cyclooxygenase-2, and epidermal growth factor receptor in colorectal adenoma tissues.	tma	37-40	cyclin D1	Homo sapiens	104-113
16954443-8	2006	In somatotroph tumors, both BIM23120 and BIM2306 caused growth arrest as indicated by the increase in p27 and decrease in cyclin D1 expression.	bim2306	41-48	cyclin D1	Homo sapiens	122-131
21783704-6	2006	MGBG also blocks the cell cycle transition caused by gamma-radiation (G(2) arrest), which helps protect cells by allowing time for DNA repair before entry into mitosis or apoptosis, via the down regulation of cyclin D1, which mediates the transition from G(1) to S phase of cell cycle, and ataxia telangiectasia mutated, which is involved in the DNA sensing, repair and cell cycle check point.	Mitoguazone	0-4	cyclin D1	Homo sapiens	209-218
16735606-6	2006	In addition, hexachlorophene represses the expression of cyclin D1, which is a known beta-catenin target gene, and inhibits the growth of colon cancer cells.	Hexachlorophene	13-28	cyclin D1	Homo sapiens	57-66
16984735-7	2006	Treatment with NT or the GSK-3 inhibitor SB216763 increased the expression of cyclin D1, a downstream effector protein of GSK-3 and a critical protein for the proliferation of various cells.	SB 216763	41-49	cyclin D1	Homo sapiens	78-87
16568089-7	2006	Mutation of the SUMO acceptor lysine to arginine enhanced the ability of Sam68 to induce apoptosis but inhibited its ability to act as a transcriptional inhibitor of cyclin D1 expression.	Lysine	30-36	cyclin D1	Homo sapiens	166-175
16568089-7	2006	Mutation of the SUMO acceptor lysine to arginine enhanced the ability of Sam68 to induce apoptosis but inhibited its ability to act as a transcriptional inhibitor of cyclin D1 expression.	Arginine	40-48	cyclin D1	Homo sapiens	166-175
16518841-5	2006	Treatment with ginsenoside Rg1, which blocked the cell cycle in the G1-phase, induced a downregulation of cyclin D1 and an upregulation in the expression of p53, p21(WAF/CIP1), and p27(KIP1).	Ginsenosides	15-26	cyclin D1	Homo sapiens	106-115
17080657-5	2006	Cyclin D1-positive cells started to increase in the boundary of the brain contusion in the 1h group.	Hydrogen	91-93	cyclin D1	Homo sapiens	0-9
16926625-9	2006	Caffeic acid phenethyl ester reduced the expression of cyclin D1 and c-myc in a dose-dependent and time-dependent manner.	caffeic acid phenethyl ester	0-28	cyclin D1	Homo sapiens	55-64
16624827-5	2006	Lauryl gallate increased p53 expression only in MCF7, and upregulated p21(Cip1) and reduced cyclin D1 levels in all three cell lines.	lauryl gallate	0-14	cyclin D1	Homo sapiens	92-101
16855382-8	2006	Furthermore, treatment with the p38 MAPK inhibitor SB203580 reduced p38 MAPK activity and cell cycle arrest, and also partially restored cyclin A, cyclin B1, cyclin D1 and p21 protein levels.	SB 203580	51-59	cyclin D1	Homo sapiens	158-167
16565789-0	2006	Lycopene inhibition of IGF-induced cancer cell growth depends on the level of cyclin D1.	Lycopene	0-8	cyclin D1	Homo sapiens	78-87
16565789-6	2006	We have previously demonstrated that slowdown of serum-stimulated cell cycle progression from G1 to S phase by lycopene correlates with reduction in cyclin D1 levels, suggesting that the expression of this protein is a main target for lycopene"s action.	Lycopene	235-243	cyclin D1	Homo sapiens	149-158
16565789-7	2006	AIM OF THE STUDY: To determine whether the reported reduction in cyclin D1 level is the key mechanism for lycopene and atRA inhibitory action on IGF-I-induced cell cycle progression.	Lycopene	106-114	cyclin D1	Homo sapiens	65-74
16565789-12	2006	Our results showed that ectopic expression of cyclin D1 can overcome cell cycle inhibition caused by lycopene and atRA.	Lycopene	101-109	cyclin D1	Homo sapiens	46-55
16565789-12	2006	Our results showed that ectopic expression of cyclin D1 can overcome cell cycle inhibition caused by lycopene and atRA.	Tretinoin	114-118	cyclin D1	Homo sapiens	46-55
16905211-6	2006	The cells were accumulated at G1 phase of the cell cycle by flavopiridol that was associated with downregulation of p-cdk-1, p-cdk-2, cyclin D1 and p-Rb expression.	alvocidib	60-72	cyclin D1	Homo sapiens	134-143
16854074-1	2006	Previously, we demonstrated that the peroxisome proliferator-activated receptor gamma (PPARgamma) agonist troglitazone mediated the repression of cyclin D1 in MCF-7 breast cancer cells by facilitating proteasome-facilitated proteolysis.	Troglitazone	106-118	cyclin D1	Homo sapiens	146-155
16854074-2	2006	This PPARgamma-independent mechanism provided a molecular basis for using troglitazone as scaffold to develop a novel class of cyclin D1-ablative agents.	Troglitazone	74-86	cyclin D1	Homo sapiens	127-136
16854074-3	2006	The proof of principle of this premise is provided by Delta2TG, in which the introduction of a double bond adjacent to the thiazolidinedione ring abrogated the PPARgamma activity while retaining the activity in cyclin D1 repression.	2,4-thiazolidinedione	123-140	cyclin D1	Homo sapiens	211-220
16854074-4	2006	Structural optimization of Delta2TG led to STG28 [(S)-5-(4-{[6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl]methoxy}-3-methoxybenzylidene)thiazolidine-2,4-dione], which exhibited low micromolar potency in ablating cyclin D1 and inhibiting MCF-7 cell proliferation.	delta2tg	27-35	cyclin D1	Homo sapiens	212-221
16854074-4	2006	Structural optimization of Delta2TG led to STG28 [(S)-5-(4-{[6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl]methoxy}-3-methoxybenzylidene)thiazolidine-2,4-dione], which exhibited low micromolar potency in ablating cyclin D1 and inhibiting MCF-7 cell proliferation.	5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione	43-48	cyclin D1	Homo sapiens	212-221
16601140-6	2006	Moreover, treatment with both SRIH and BIM-23120 decreases cyclin D1 levels, with a parallel increase in phosphocyclin D1 levels, suggesting protein degradation.	bim	39-42	cyclin D1	Homo sapiens	59-68
16601140-8	2006	Indeed, we observed a reduction in cyclin D1 protein half-life under treatment with SRIH or the SSTR2 selective agonist.	srih	84-88	cyclin D1	Homo sapiens	35-44
16601140-10	2006	Our data indicate that the subtype 2 receptor-mediated antiproliferative effect of SRIH on TT cell proliferation may be exerted through a decrease in cyclin D1 levels.	srih	83-87	cyclin D1	Homo sapiens	150-159
16772336-4	2006	CoCl(2) treatment increased the expression of the anti-proliferative gene BTG2/PC3 and decreased cyclin D1 expression.	cobaltous chloride	0-7	cyclin D1	Homo sapiens	97-106
16805953-6	2006	Sal A at 10 microM induced cell apoptosis in PDGF-BB-incubated HSCs, together with a reduction of Bcl-2 protein expression, induction of cell cycle inhibitory proteins p21 and p27, and down-regulation of cyclins D1 and E, suppression of Akt phosphorylation, reduction in PDGF receptor phosphorylation, and an increase in caspase-3 activity.	salvianolic acid A	0-5	cyclin D1	Homo sapiens	204-220
16699726-0	2006	Benzo[a]pyrene-induced cell cycle progression is through ERKs/cyclin D1 pathway and requires the activation of JNKs and p38 mapk in human diploid lung fibroblasts.	Benzo(a)pyrene	0-14	cyclin D1	Homo sapiens	62-71
16786142-3	2006	We observed that the proliferation-inhibitory effect of dideoxypetrosynol A was due to the induction of G1 arrest in the cell cycle, the effects of which were associated with up-regulation of cyclin D1 and down-regulation of cyclin E, in a concentration-dependent manner without any change in cyclin-dependent-kinases (Cdks) expression.	dideoxypetrosynol A	56-75	cyclin D1	Homo sapiens	192-201
17067457-2	2006	METHODS: Immunohistochemistry SP method was used to detect the expression of PTEN, PIP3 and cyclin D1 in 63 cases of oral squamous cell carcinoma, 29 cases of simple hyperplasia, 33 cases of dysplasia, and 25 cases of normal oral mucosa.	TFF2 protein, human	30-32	cyclin D1	Homo sapiens	92-101
16613857-5	2006	Mutagenesis of Runx2 serine-472, a consensus Cdk site, to alanine increases the half-life of Runx2 and causes loss of sensitivity to cyclin D1-induced Runx2 degradation.	Serine	21-27	cyclin D1	Homo sapiens	133-142
16613857-5	2006	Mutagenesis of Runx2 serine-472, a consensus Cdk site, to alanine increases the half-life of Runx2 and causes loss of sensitivity to cyclin D1-induced Runx2 degradation.	Alanine	58-65	cyclin D1	Homo sapiens	133-142
16776827-13	2006	Furthermore, Simvastatin dose-dependently inhibited fibroblast cyclin D1 gene and protein expression, inducing G1 cell cycle arrest.	Simvastatin	13-24	cyclin D1	Homo sapiens	63-72
16776827-16	2006	This potentially unravels new molecular targets for future anti-IPF strategies; accordingly, Simvastatin inhibition of Rho-mediated cyclin D1 expression in IPF fibroblasts merits further exploitation.	Simvastatin	93-104	cyclin D1	Homo sapiens	132-141
16944783-0	2006	Vitamin C inhibits benzo[a]pyrene-induced cell cycle changes partly via cyclin D1/E2F pathway in human embryo lung fibroblasts.	Ascorbic Acid	0-9	cyclin D1	Homo sapiens	72-81
16944783-0	2006	Vitamin C inhibits benzo[a]pyrene-induced cell cycle changes partly via cyclin D1/E2F pathway in human embryo lung fibroblasts.	Benzo(a)pyrene	19-33	cyclin D1	Homo sapiens	72-81
16944783-6	2006	Vitamin C decreased the expression levels of cyclin D1, E2F1, and E2F4 in B[a]P-stimulated HELF cells.	Ascorbic Acid	0-9	cyclin D1	Homo sapiens	45-54
16944783-9	2006	The expression levels of cyclin D1 and E2F4 treated with vitamin C and antisense cyclin D1 were decreased compared with those treated with antisense cyclin D1 alone.	Ascorbic Acid	57-66	cyclin D1	Homo sapiens	25-34
16944783-10	2006	The effects of vitamin C combined with antisense CDK4 on the expression levels of cyclin D1 and E2F1/E2F4 were similar to those of antisense CDK4 alone.	Ascorbic Acid	15-24	cyclin D1	Homo sapiens	82-91
16740736-5	2006	MKP3 overexpression was associated with lower levels of activated extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation in the presence of estrogen but that estrogen deprivation and tamoxifen treatment decreased MKP3 phosphatase activity, leading to an up-regulation of pERK1/2 MAPK, phosphorylated Ser(118)-ER-alpha, and cyclin D1.	Tamoxifen	195-204	cyclin D1	Homo sapiens	335-344
16603604-3	2006	On H2O2 treatment, endothelial cells showed a rapid down-modulation of cyclin D1.	Hydrogen Peroxide	3-7	cyclin D1	Homo sapiens	71-80
16603604-5	2006	H2O2 treatment induced cyclin D1 ubiquitination followed by proteasome degradation.	Hydrogen Peroxide	0-4	cyclin D1	Homo sapiens	23-32
16603604-10	2006	In fact, H2O2 stimulated CaMK activity, CaMK inhibitors prevented H2O2-induced cyclin D1 down-modulation, and CaMK overexpression induced cyclin D1 degradation.	Hydrogen Peroxide	66-70	cyclin D1	Homo sapiens	79-88
16603604-11	2006	Finally, overriding of cyclin D1 down-modulation via its forced overexpression or via CaMK inhibition increased cell sensitivity to H2O2-induced apoptotic cell death.	Hydrogen Peroxide	132-136	cyclin D1	Homo sapiens	23-32
16728278-13	2006	IGF-I phosphorylated Akt and upregulated cyclin D1 in the CD56(+) KMS-21-BM cells, which was completely blocked by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	115-123	cyclin D1	Homo sapiens	41-50
16980581-4	2006	Here, we show that estradiol (E2) stimulation of CCND1 expression in BCC depends on a novel cell-type-specific enhancer downstream from the CCND1 coding region, which is the primary ERalpha recruitment site in estrogen-responsive cells.	Estradiol	19-28	cyclin D1	Homo sapiens	140-145
16705174-6	2006	cyclin D1(-/-) cells showed increased Rho GTP and ROCKII activity and signaling, with increased phosphorylation of LIM kinase, cofilin (Ser3), and myosin light chain 2 (Thr18/Ser19).	Guanosine Triphosphate	42-45	cyclin D1	Homo sapiens	0-9
16705174-6	2006	cyclin D1(-/-) cells showed increased Rho GTP and ROCKII activity and signaling, with increased phosphorylation of LIM kinase, cofilin (Ser3), and myosin light chain 2 (Thr18/Ser19).	UNII-PYZ33YLR8A	169-174	cyclin D1	Homo sapiens	0-9
16836906-15	2006	CONCLUSIONS: Antisense oligonucleotides of cyclin D1 can improve the sensibility of Tca8113/CDDP cells to cisplatin and inhibit the growth of tumors.	Oligonucleotides	23-39	cyclin D1	Homo sapiens	43-52
16836906-15	2006	CONCLUSIONS: Antisense oligonucleotides of cyclin D1 can improve the sensibility of Tca8113/CDDP cells to cisplatin and inhibit the growth of tumors.	Cisplatin	106-115	cyclin D1	Homo sapiens	43-52
16556598-9	2006	Instead, we identify PKCalpha as a novel repressor of cyclin D1 translation, acting at the level of cap-dependent initiation.	cap	100-103	cyclin D1	Homo sapiens	54-63
16051428-3	2006	In contrast, 10 microM 5,5"-diBrDIM downregulated cyclin D1 protein in MCF-7 and MDA-MB-231 cells 12 and 24 h after treatment.	5,5"-dibrdim	23-35	cyclin D1	Homo sapiens	50-59
16497706-10	2006	The immunoblot analysis data revealed that in both cell lines panduratin A treatment resulted in a dose-dependent (i) induction of p21WAF1/Cip1 and p27Kip1, (ii) downregulation of cdks 2, 4 and 6 and (iii) decrease in cyclins D1 and E.	panduratin A	62-74	cyclin D1	Homo sapiens	218-234
16051428-4	2006	DIM (20 microM) also decreased cyclin D1 in MCF-7 (24 h) and MDA-MB-231 (12 h), and the DIM/5,5"-diBrDIM-induced degradation of cyclin D1 was blocked by the proteasome inhibitor MG132.	dim/5,5"-dibrdim	88-104	cyclin D1	Homo sapiens	128-137
16051428-4	2006	DIM (20 microM) also decreased cyclin D1 in MCF-7 (24 h) and MDA-MB-231 (12 h), and the DIM/5,5"-diBrDIM-induced degradation of cyclin D1 was blocked by the proteasome inhibitor MG132.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	178-183	cyclin D1	Homo sapiens	128-137
16705121-6	2006	Tamoxifen responsiveness of human MCF-7 breast cancer cells that inducibly expressed constitutively active Pak1 or that transiently overexpressed wild-type Pak1 (Wt-Pak1) or Pak1 that lacked functional nuclear localization signals (Pak1DeltaNLS) was evaluated by analyzing cyclin D1 promoter activation and protein levels as markers for ERalpha activation.	Tamoxifen	0-9	cyclin D1	Homo sapiens	273-282
16551621-4	2006	Consistent with data from other cell types we demonstrate that both Rac1 and Rac1b stimulate transcriptional activation from reporter genes driven by NF-kappaB motifs or the cyclin D1 promoter in an IkappaBalpha- and reactive oxygen species-dependent manner.	Reactive Oxygen Species	217-240	cyclin D1	Homo sapiens	174-183
16651438-4	2006	Consistent with the increased Fas/CD95 expression, a drastic decrease in the Tyr(705) phosphorylation of STAT3, a known negative regulator of Fas/CD95 transcription, was found within 20 minutes in the luteolin-treated cells, leading to down-regulation in the target gene products of STAT3, such as cyclin D1, survivin, Bcl-xL, and vascular endothelial growth factor.	Tyrosine	77-80	cyclin D1	Homo sapiens	298-307
16337966-5	2006	Only a low dose of bile acid induced the expression of cyclin D1 and CDC25A and showed high Rb phosphorylation and high CDK2 kinase activity.	Bile Acids and Salts	19-28	cyclin D1	Homo sapiens	55-64
16630125-8	2006	Curcumin reduced the expression of cell cycle regulators, cyclin D1 and c-Myc proteins, which are both degraded by activated GSK-3beta.	Curcumin	0-8	cyclin D1	Homo sapiens	58-67
16622124-13	2006	ZSTK474 inhibited phosphorylation of signaling components downstream from PI3K, such as Akt and glycogen synthase kinase 3beta, and mediated a decrease in cyclin D1 levels.	ZSTK474	0-7	cyclin D1	Homo sapiens	155-164
16550520-6	2006	The effect of celecoxib on growth inhibition was accompanied by the downregulation of cyclin D1 and cyclin E and p-Rb expression, the upregulation of P16(INK4a) and P27KIP expression, and a G1-S phase arrest of the cell cycle.	Celecoxib	14-23	cyclin D1	Homo sapiens	86-95
16387740-3	2006	Cyclin D1, a nuclear protein playing a pivotal role in cell proliferation and cell cycle transition from G1 to S phases, has been reported to be induced in human fibroblast by arsenite via uncertain molecular mechanisms.	arsenite	176-184	cyclin D1	Homo sapiens	0-9
16564150-10	2006	ER stress inducers tunicamycin and thapsigargin down-regulate cell cycle proteins ppRb and cyclin D1 in differentiated neuroblastoma cells.	Tunicamycin	19-30	cyclin D1	Homo sapiens	91-100
19771269-9	2006	NaBT treatment in combination with PI3K inhibitors showed the increased expression of the CDK inhibitors p21(Cip1/Waf1) and p27(Kip1), in a p53 dependent manner, and also the increased dephosphorylation of Rb whereas there was a reduction in the expression levels of cyclin A, cyclin D1 and cyclin B1.	NABT	0-4	cyclin D1	Homo sapiens	277-286
16564150-10	2006	ER stress inducers tunicamycin and thapsigargin down-regulate cell cycle proteins ppRb and cyclin D1 in differentiated neuroblastoma cells.	Thapsigargin	35-47	cyclin D1	Homo sapiens	91-100
16944582-2	2006	The siRNA targeting cyclin D1 was chemically synthesized and transfected into MCF-7 cells by oligofectamine.	oligofectamine	93-107	cyclin D1	Homo sapiens	20-29
16616093-2	2006	DESIGN: Immunohistochemical study for p16, pRb, and cyclin D1 proteins in formalin-fixed paraffin-embedded endometriotic and adenomyotic tissues.	Formaldehyde	74-82	cyclin D1	Homo sapiens	52-61
16616093-2	2006	DESIGN: Immunohistochemical study for p16, pRb, and cyclin D1 proteins in formalin-fixed paraffin-embedded endometriotic and adenomyotic tissues.	Paraffin	89-97	cyclin D1	Homo sapiens	52-61
16217753-9	2006	The erlotinib-mediated signaling involved the inactivation of EGFR-TK and ERK1/2, the upregulation of the cyclin-dependent kinase inhibitors p21(Waf1/CIP1) and p27(Kip1), and the downregulation of the cell cycle promoter cyclin D1.	Erlotinib Hydrochloride	4-13	cyclin D1	Homo sapiens	221-230
16648567-7	2006	Furthermore, down-regulation of CDK2, CDK4, and cyclin D1 was observed in PC3 cells treated with 1,000 nmol/L of MONCPT, whereas overexpression of CDK7, CDK1, and cyclin B1 was seen in PC3 cells treated with 10 and 100 nmol/L of MONCPT.	10-methoxy-9-nitrocamptothecin	113-119	cyclin D1	Homo sapiens	48-57
16648570-7	2006	When compared with scrambled oligodeoxynucleotide, we found that the 18-mer TCF decoy significantly inhibited TCF activity and promoter activities of the downstream target genes, such as cyclin D1, c-myc, and matrix metalloproteinase 7 in HCT116 colon cancer cells.	Oligodeoxyribonucleotides	29-49	cyclin D1	Homo sapiens	187-196
16495921-2	2006	A common adenine to guanine polymorphism (A870G) in the CCND1 gene has been associated with a longer-life protein and an increased risk of colorectal cancer and adenoma in some studies.	Adenine	9-16	cyclin D1	Homo sapiens	56-61
16495921-2	2006	A common adenine to guanine polymorphism (A870G) in the CCND1 gene has been associated with a longer-life protein and an increased risk of colorectal cancer and adenoma in some studies.	Guanine	20-27	cyclin D1	Homo sapiens	56-61
16586549-0	2006	Cyclin D1 antisense oligodexoyneucleotides inhibits growth and enhances chemosensitivity in gastric carcinoma cells.	oligodexoyneucleotides	20-42	cyclin D1	Homo sapiens	0-9
16586549-1	2006	AIM: To examine the effects of cyclin D1 antisense oligodexoyneucleotides (ASODN) on growth and chemosensitivity of gastric carcinoma cell lines SGC7901 and its mechanism.	asodn	75-80	cyclin D1	Homo sapiens	31-40
16586549-2	2006	METHODS: Phosphorothioate modified cyclin D1 ASODN was encapsulated by LipofectAMINE2000 (LF2000) and transfected into cells, the dose-effect curves and growth curves were observed.	Parathion	9-25	cyclin D1	Homo sapiens	35-44
16586549-2	2006	METHODS: Phosphorothioate modified cyclin D1 ASODN was encapsulated by LipofectAMINE2000 (LF2000) and transfected into cells, the dose-effect curves and growth curves were observed.	Lipofectamine	71-88	cyclin D1	Homo sapiens	35-44
16586549-3	2006	5-FU, MTX, CDDP of different concentrations were given after transfecting cells with cyclin D1 ASODN for 24 h the dose-effect responses were observed and IC50s were calculated.	Fluorouracil	0-4	cyclin D1	Homo sapiens	85-94
16586549-3	2006	5-FU, MTX, CDDP of different concentrations were given after transfecting cells with cyclin D1 ASODN for 24 h the dose-effect responses were observed and IC50s were calculated.	cddp	11-15	cyclin D1	Homo sapiens	85-94
16586549-7	2006	Cyclin D1 ASODN could increase the chemosensitivity to 5-FU, MTX, CDDP in cells.	Fluorouracil	55-59	cyclin D1	Homo sapiens	0-9
16586549-7	2006	Cyclin D1 ASODN could increase the chemosensitivity to 5-FU, MTX, CDDP in cells.	Methotrexate	61-64	cyclin D1	Homo sapiens	0-9
16586549-7	2006	Cyclin D1 ASODN could increase the chemosensitivity to 5-FU, MTX, CDDP in cells.	cddp	66-70	cyclin D1	Homo sapiens	0-9
16551874-7	2006	Ritonavir causes G1 arrest, depletes cyclin-dependent kinases 2, 4, and 6 and cyclin D1 but not cyclin E, and depletes phosphorylated Rb and Ser473 Akt.	Ritonavir	0-9	cyclin D1	Homo sapiens	78-87
16538382-9	2006	The phosphate conjugated 5-FdUrd-araC heterodimer (5-Fluoro-2"-desoxyuridylyl-(3"--&gt;5")-Arabinocytidine), which is a prodrug of AraC-monophosphate, reactivated AIF and down-regulated cyclin D1 in AraC-resistant cells and circumvented resistance to apoptosis and to cell cycle inhibition.	Phosphates	4-13	cyclin D1	Homo sapiens	186-195
16538382-9	2006	The phosphate conjugated 5-FdUrd-araC heterodimer (5-Fluoro-2"-desoxyuridylyl-(3"--&gt;5")-Arabinocytidine), which is a prodrug of AraC-monophosphate, reactivated AIF and down-regulated cyclin D1 in AraC-resistant cells and circumvented resistance to apoptosis and to cell cycle inhibition.	Floxuridine	26-32	cyclin D1	Homo sapiens	186-195
16538382-9	2006	The phosphate conjugated 5-FdUrd-araC heterodimer (5-Fluoro-2"-desoxyuridylyl-(3"--&gt;5")-Arabinocytidine), which is a prodrug of AraC-monophosphate, reactivated AIF and down-regulated cyclin D1 in AraC-resistant cells and circumvented resistance to apoptosis and to cell cycle inhibition.	5-fluoro-2"-desoxyuridylyl-(3"--&gt	51-86	cyclin D1	Homo sapiens	186-195
16538382-9	2006	The phosphate conjugated 5-FdUrd-araC heterodimer (5-Fluoro-2"-desoxyuridylyl-(3"--&gt;5")-Arabinocytidine), which is a prodrug of AraC-monophosphate, reactivated AIF and down-regulated cyclin D1 in AraC-resistant cells and circumvented resistance to apoptosis and to cell cycle inhibition.	arac-monophosphate	131-149	cyclin D1	Homo sapiens	186-195
16538382-9	2006	The phosphate conjugated 5-FdUrd-araC heterodimer (5-Fluoro-2"-desoxyuridylyl-(3"--&gt;5")-Arabinocytidine), which is a prodrug of AraC-monophosphate, reactivated AIF and down-regulated cyclin D1 in AraC-resistant cells and circumvented resistance to apoptosis and to cell cycle inhibition.	Cytarabine	131-135	cyclin D1	Homo sapiens	186-195
16549753-1	2006	OBJECTIVES: To determine expression of cell cycle and apoptotic genes, biochemical analysis of CCL23 and antisense cyclin D1-transfected CCL23 (CCL23AS) cells in the presence of cisplatin was performed.	Cisplatin	178-187	cyclin D1	Homo sapiens	115-124
16549753-10	2006	There was decreased phosphorylation of Rb protein with complete absence of hyperphosphorylated Rb in the maximally sensitized antisense cyclin D1-transfected (CCL23AS) cells.	Rubidium	39-41	cyclin D1	Homo sapiens	136-145
16758952-0	2006	[Benzo(a)pyrene induced changes of cyclin D1, CDK4 and E2F-1/4 expression in human embryo lung fibroblasts].	Benzo(a)pyrene	1-15	cyclin D1	Homo sapiens	35-44
16503970-3	2006	We have demonstrated previously, that TSA induces the ubiquitin-dependent degradation of cyclin D1 in MCF-7 breast cancer cells.	trichostatin A	38-41	cyclin D1	Homo sapiens	89-98
16503970-4	2006	Additional studies were initiated in order to further investigate the effect of TSA on cyclin D1 regulation using sub-cellular fractionation techniques.	trichostatin A	80-83	cyclin D1	Homo sapiens	87-96
16512916-0	2006	Disruption of nucleocytoplasmic trafficking of cyclin D1 and topoisomerase II by sanguinarine.	sanguinarine	81-93	cyclin D1	Homo sapiens	47-56
16344270-9	2006	Violacein causes cell cycle block at G(1), upregulates p53, p27 and p21 levels and decreases the expression of cyclin D1.	violacein	0-9	cyclin D1	Homo sapiens	111-120
16522728-13	2006	The stimulation of the cyclin D1 promoter by GLP-1 was inhibited by H89, wortmannin, and PD98059.	Wortmannin	73-83	cyclin D1	Homo sapiens	23-32
16522728-13	2006	The stimulation of the cyclin D1 promoter by GLP-1 was inhibited by H89, wortmannin, and PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	89-96	cyclin D1	Homo sapiens	23-32
16406195-0	2006	Cyclin D1 (CCND1) A870G gene polymorphism modulates smoking-induced lung cancer risk and response to platinum-based chemotherapy in non-small cell lung cancer (NSCLC) patients.	Platinum	101-109	cyclin D1	Homo sapiens	0-9
16406195-0	2006	Cyclin D1 (CCND1) A870G gene polymorphism modulates smoking-induced lung cancer risk and response to platinum-based chemotherapy in non-small cell lung cancer (NSCLC) patients.	Platinum	101-109	cyclin D1	Homo sapiens	11-16
16640900-9	2006	The expression levels of above proteins with vitamin C combined with antisense cyclin D1 were decreased as compared to those with antisense cyclin D1 alone.	Ascorbic Acid	45-54	cyclin D1	Homo sapiens	140-149
16640900-12	2006	CONCLUSION: Vitamin C might reserve the B (a) P-induced changes of cell cycle via intracellular signaling pathway of cyclin D1-CDK4/E2F-1/4.	Ascorbic Acid	12-21	cyclin D1	Homo sapiens	117-126
16640900-12	2006	CONCLUSION: Vitamin C might reserve the B (a) P-induced changes of cell cycle via intracellular signaling pathway of cyclin D1-CDK4/E2F-1/4.	Benzo(a)pyrene	40-47	cyclin D1	Homo sapiens	117-126
16504004-0	2006	Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells.	trichostatin A	31-45	cyclin D1	Homo sapiens	74-83
16504004-2	2006	GSK3beta phosphorylates cyclin D1 on Thr-286, resulting in enhanced ubiquitylation, nuclear export and degradation of the cyclin in the cytoplasm.	Threonine	37-40	cyclin D1	Homo sapiens	24-33
16504004-4	2006	We have previously shown that the histone deacetylase inhibitor trichostatin A (TSA) induces the rapid ubiquitin-dependent degradation of cyclin D1 in MCF-7 breast cancer cells prior to repression of cyclin D1 gene (CCND1) transcription.	trichostatin A	64-78	cyclin D1	Homo sapiens	138-147
16504004-4	2006	We have previously shown that the histone deacetylase inhibitor trichostatin A (TSA) induces the rapid ubiquitin-dependent degradation of cyclin D1 in MCF-7 breast cancer cells prior to repression of cyclin D1 gene (CCND1) transcription.	trichostatin A	64-78	cyclin D1	Homo sapiens	200-209
16504004-4	2006	We have previously shown that the histone deacetylase inhibitor trichostatin A (TSA) induces the rapid ubiquitin-dependent degradation of cyclin D1 in MCF-7 breast cancer cells prior to repression of cyclin D1 gene (CCND1) transcription.	trichostatin A	64-78	cyclin D1	Homo sapiens	216-221
16504004-4	2006	We have previously shown that the histone deacetylase inhibitor trichostatin A (TSA) induces the rapid ubiquitin-dependent degradation of cyclin D1 in MCF-7 breast cancer cells prior to repression of cyclin D1 gene (CCND1) transcription.	trichostatin A	80-83	cyclin D1	Homo sapiens	138-147
16504004-4	2006	We have previously shown that the histone deacetylase inhibitor trichostatin A (TSA) induces the rapid ubiquitin-dependent degradation of cyclin D1 in MCF-7 breast cancer cells prior to repression of cyclin D1 gene (CCND1) transcription.	trichostatin A	80-83	cyclin D1	Homo sapiens	200-209
16504004-4	2006	We have previously shown that the histone deacetylase inhibitor trichostatin A (TSA) induces the rapid ubiquitin-dependent degradation of cyclin D1 in MCF-7 breast cancer cells prior to repression of cyclin D1 gene (CCND1) transcription.	trichostatin A	80-83	cyclin D1	Homo sapiens	216-221
16504004-5	2006	TSA treatment also resulted in accumulation of polyubiquitylated GFP-cyclin D1 species and reduced levels of the recombinant protein within the nucleus.	trichostatin A	0-3	cyclin D1	Homo sapiens	69-78
16504004-6	2006	RESULTS: Here we provide further evidence for TSA-induced ubiquitin-dependent degradation of cyclin D1 and demonstrate that GSK3beta-mediated nuclear export facilitates this activity.	trichostatin A	46-49	cyclin D1	Homo sapiens	93-102
16504004-7	2006	Our observations suggest that TSA treatment results in enhanced cyclin D1 degradation via the GSK3beta/CRM1-dependent nuclear export/26S proteasomal degradation pathway in MCF-7 cells.	trichostatin A	30-33	cyclin D1	Homo sapiens	64-73
16504004-8	2006	CONCLUSION: We have demonstrated that rapid TSA-induced cyclin D1 degradation in MCF-7 cells requires GSK3beta-mediated Thr-286 phosphorylation and the ubiquitin-dependent 26S proteasome pathway.	trichostatin A	44-47	cyclin D1	Homo sapiens	56-65
16504004-8	2006	CONCLUSION: We have demonstrated that rapid TSA-induced cyclin D1 degradation in MCF-7 cells requires GSK3beta-mediated Thr-286 phosphorylation and the ubiquitin-dependent 26S proteasome pathway.	Threonine	120-123	cyclin D1	Homo sapiens	56-65
16302003-6	2006	Furthermore, we found that pharmacological intervention with low micromolar concentrations of N-(4-hydroxyphenyl)retinamide (4-HPR), which downmodulates cyclin D1, induced G1 arrest and apoptosis in rhabdoid cell lines.	Fenretinide	94-123	cyclin D1	Homo sapiens	153-162
16526280-5	2006	The increased sub-G1 population may, in turn, result from a reduction of cyclin D1 and B1 expression by cisplatin in the presence of p73.	Cisplatin	104-113	cyclin D1	Homo sapiens	73-82
16412023-6	2006	LY209002 induced cell cycle arrest in the G0/G1 phase and apoptosis, which were associated with upregulation of MDM2, downregulation of cyclin D1, activation of caspase 9 and poly-ADP-ribose polymerase cleavage.	ly209002	0-8	cyclin D1	Homo sapiens	136-145
16170570-0	2006	p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1.	sulforaphane	77-89	cyclin D1	Homo sapiens	162-171
16170570-5	2006	At high doses (&gt;25 microM), SFN dramatically induces the expression of p21(CIP1) while significantly inhibits the expression of the G(1) phase cell cycle regulatory genes such as cyclin D1, cyclin A, and c-myc.	sulforaphane	31-34	cyclin D1	Homo sapiens	182-191
16170570-8	2006	Exposure of HT-29 cells with both SFN and an antioxidant, either NAC or GSH, completely blocked the SFN-mediated activation of these MAPK signaling cascades, regulation of cyclin D1and p21(CIP1) gene expression, and G(1)phase cell cycle arrest.	sulforaphane	34-37	cyclin D1	Homo sapiens	172-181
16170570-8	2006	Exposure of HT-29 cells with both SFN and an antioxidant, either NAC or GSH, completely blocked the SFN-mediated activation of these MAPK signaling cascades, regulation of cyclin D1and p21(CIP1) gene expression, and G(1)phase cell cycle arrest.	Glutathione	72-75	cyclin D1	Homo sapiens	172-181
16170570-8	2006	Exposure of HT-29 cells with both SFN and an antioxidant, either NAC or GSH, completely blocked the SFN-mediated activation of these MAPK signaling cascades, regulation of cyclin D1and p21(CIP1) gene expression, and G(1)phase cell cycle arrest.	sulforaphane	100-103	cyclin D1	Homo sapiens	172-181
16490596-7	2006	Our data indicated an association with alcohol consumption and the CCND1 gene or protein levels, in both esophageal and gastric cancers.	Alcohols	39-46	cyclin D1	Homo sapiens	67-72
16406622-0	2006	Inhibition of benzo(a)pyrene-induced cell cycle progression by all-trans retinoic acid partly through cyclin D1/E2F-1 pathway in human embryo lung fibroblasts.	pyrene	22-28	cyclin D1	Homo sapiens	102-111
16406622-0	2006	Inhibition of benzo(a)pyrene-induced cell cycle progression by all-trans retinoic acid partly through cyclin D1/E2F-1 pathway in human embryo lung fibroblasts.	Tretinoin	73-86	cyclin D1	Homo sapiens	102-111
16406622-4	2006	Our results showed that after treatment with B(a)P, the expression of cyclin D1 and E2F-1 were both increased significantly in HELF.	Benzo(a)pyrene	45-50	cyclin D1	Homo sapiens	70-79
16406622-5	2006	There were almost no changes of CDK4 and E2F-4 expression by treatment with B(a)P. As expected, pretreatment with ATRA could efficiently decrease B(a)P-induced overexpression of cyclin D1 and E2F-1.	Tretinoin	114-118	cyclin D1	Homo sapiens	178-187
16406622-8	2006	Pretreatment with ATRA, cells expressing antisense cyclinD1 or antisense CDK4 showed a lesser decrease of B(a)P-induced overexpression of E2F-1 compared with similarly treated HELF.	Tretinoin	18-22	cyclin D1	Homo sapiens	51-59
16406622-10	2006	It was suggested that ATRA could block B(a)P-induced cell cycle promotion partly through the cyclin D1/E2F-1 pathway in HELF.	Tretinoin	22-26	cyclin D1	Homo sapiens	93-102
16406622-10	2006	It was suggested that ATRA could block B(a)P-induced cell cycle promotion partly through the cyclin D1/E2F-1 pathway in HELF.	Benzo(a)pyrene	39-44	cyclin D1	Homo sapiens	93-102
16479154-3	2006	Cyclin D1 overexpression markedly increased the apoptotic response of cells to the CDK inhibitors flavopiridol, roscovitine, and R-roscovitine.	alvocidib	98-110	cyclin D1	Homo sapiens	0-9
16479154-3	2006	Cyclin D1 overexpression markedly increased the apoptotic response of cells to the CDK inhibitors flavopiridol, roscovitine, and R-roscovitine.	Roscovitine	112-123	cyclin D1	Homo sapiens	0-9
16479154-3	2006	Cyclin D1 overexpression markedly increased the apoptotic response of cells to the CDK inhibitors flavopiridol, roscovitine, and R-roscovitine.	Roscovitine	129-142	cyclin D1	Homo sapiens	0-9
16355386-6	2006	DHMEQ strongly inhibited cyclin D1 and vascular endothelial growth factor (VEGF) promoter activity and decreased the levels of cyclin D1 protein and VEGF mRNA in KB cells.	dehydroxymethylepoxyquinomicin	0-5	cyclin D1	Homo sapiens	25-34
16355386-6	2006	DHMEQ strongly inhibited cyclin D1 and vascular endothelial growth factor (VEGF) promoter activity and decreased the levels of cyclin D1 protein and VEGF mRNA in KB cells.	dehydroxymethylepoxyquinomicin	0-5	cyclin D1	Homo sapiens	127-136
16106398-5	2006	Curcumin induced cell cycle arrest by reducing the expression of cyclin D1, Cdk1 and Cdc25C and apoptosis by reducing the expression of XIAP and survivin.	Curcumin	0-8	cyclin D1	Homo sapiens	65-74
16525614-4	2006	Treated with 220 micromol/L of genistein for 3 days, the expression level of CyclinB1, Cdk1, CyclinD1 and Cdk4 proteins was 58%, 64%, 46% and 43% of the control group, respectively (P&lt;0.01).	Genistein	31-40	cyclin D1	Homo sapiens	93-101
16125882-0	2006	Overexpression of cyclin D1-CDK4 in silica-induced transformed cells is due to activation of ERKs, JNKs/AP-1 pathway.	Silicon Dioxide	36-42	cyclin D1	Homo sapiens	18-27
16125882-6	2006	Further studies showed that there are differential effects of ERKs, JNKs and p38K, as well as their downstream transcription factor AP-1, in regulation of expression of cyclin D1 and CDK4 and cell cycle alternations induced by silica.	Silicon Dioxide	227-233	cyclin D1	Homo sapiens	169-178
16125882-8	2006	Inhibition of ERKs activation by AG126, JNK by SP600125, and AP-1 by curcumin could reduced the induction of cyclin D1 and CDK4.	AG 127	33-38	cyclin D1	Homo sapiens	109-118
16125882-8	2006	Inhibition of ERKs activation by AG126, JNK by SP600125, and AP-1 by curcumin could reduced the induction of cyclin D1 and CDK4.	pyrazolanthrone	47-55	cyclin D1	Homo sapiens	109-118
16125882-8	2006	Inhibition of ERKs activation by AG126, JNK by SP600125, and AP-1 by curcumin could reduced the induction of cyclin D1 and CDK4.	Curcumin	69-77	cyclin D1	Homo sapiens	109-118
16125882-10	2006	These results demonstrate that ERKs and JNKs, but not p38K is responsible for induction of cyclin D1 and CDK4 in S-HELF, suggesting that overexpression of cyclin D1 and CDK4 caused by silica is mediated by ERK, JNK/AP-1signaling pathway.	Silicon Dioxide	184-190	cyclin D1	Homo sapiens	155-164
16426443-7	2006	Significant association was observed between Ki-67 and cyclin D1 positivity (P = 0.045).	ki-67	45-50	cyclin D1	Homo sapiens	55-64
16413407-4	2006	As for the positive controls adozelesin and cisplatin, arrest was accompanied by phosphorylation of ATM kinase; dephosphorylation of pRB; decreases in RF-C, cyclin D1, Cdc25A, and Cdc6; and increases in p21.	Cisplatin	44-53	cyclin D1	Homo sapiens	157-166
16413407-7	2006	Induction of phosphatase activity may represent one mechanism of RNS-induced arrest, for the PP1/PP2A phosphatase inhibitor okadaic acid inhibited dephosphorylation of pRB; prevented decreases in the levels of RF-C, cyclin D1, Cdc6, and Cdc25A; and bypassed arrest by SIN-1 or NO(2), but not cisplatin or adozelesin.	Reactive Nitrogen Species	65-68	cyclin D1	Homo sapiens	216-225
16413407-7	2006	Induction of phosphatase activity may represent one mechanism of RNS-induced arrest, for the PP1/PP2A phosphatase inhibitor okadaic acid inhibited dephosphorylation of pRB; prevented decreases in the levels of RF-C, cyclin D1, Cdc6, and Cdc25A; and bypassed arrest by SIN-1 or NO(2), but not cisplatin or adozelesin.	Okadaic Acid	124-136	cyclin D1	Homo sapiens	216-225
16424043-0	2006	Rapamycin disrupts cyclin/cyclin-dependent kinase/p21/proliferating cell nuclear antigen complexes and cyclin D1 reverses rapamycin action by stabilizing these complexes.	Sirolimus	122-131	cyclin D1	Homo sapiens	103-112
16170359-4	2006	We recently reported that curcumin inhibited the growth of human colon cancer-derived Moser cells by suppressing gene expression of cyclinD1 and EGFR.	Curcumin	26-34	cyclin D1	Homo sapiens	132-140
16644573-0	2006	p53 mutation and cyclin D1 amplification correlate with cisplatin sensitivity in xenografted human squamous cell carcinomas from head and neck.	Cisplatin	56-65	cyclin D1	Homo sapiens	17-26
16374552-3	2006	Exposure of these cells to 20 nM okadaic acid induced apoptosis-associated caspase 3 activation, DNA fragmentation, cleavage of Poly ADP-Ribose Polymerase (PARP), p53-independent expression of pro-apoptotic bax, and loss of proliferation-promoting cyclin D1.	Okadaic Acid	33-45	cyclin D1	Homo sapiens	248-257
16374552-5	2006	Ectopic overexpression of the cyclin D1 gene in A431 carcinoma conferred resistance to 20 nM okadaic acid irrespective of exogenous EGF, associated with a parallel induction of anti-apoptotic bcl-2.	Okadaic Acid	93-105	cyclin D1	Homo sapiens	30-39
16374552-6	2006	Treatment with a subtoxic concentration of a bispecific bcl-2/bcl xL antisense oligonucleotide cooperated with okadaic acid to down-regulate bcl-2 and sensitize cyclin D1-overexpressing cells to okadaic acid.	Oligonucleotides	79-94	cyclin D1	Homo sapiens	161-170
16374552-6	2006	Treatment with a subtoxic concentration of a bispecific bcl-2/bcl xL antisense oligonucleotide cooperated with okadaic acid to down-regulate bcl-2 and sensitize cyclin D1-overexpressing cells to okadaic acid.	Okadaic Acid	111-123	cyclin D1	Homo sapiens	161-170
16374552-6	2006	Treatment with a subtoxic concentration of a bispecific bcl-2/bcl xL antisense oligonucleotide cooperated with okadaic acid to down-regulate bcl-2 and sensitize cyclin D1-overexpressing cells to okadaic acid.	Okadaic Acid	195-207	cyclin D1	Homo sapiens	161-170
16374552-7	2006	Although EGF protects EGF-R proficient epithelial cells from diverse apoptotic stimuli through Mcl-1, this is the first report demonstrating that cyclin D1 overexpression provides an EGF independent protection from okadaic acid-induced cell death through induction of bcl-2.	Okadaic Acid	215-227	cyclin D1	Homo sapiens	146-155
16343270-4	2006	Moreover, the influence of SAHA on the expression of cyclin D1, the cell cycle regulators p21 and p27 and the production of vascular endothelial growth factor (VEGF) were analyzed.	Vorinostat	27-31	cyclin D1	Homo sapiens	53-62
16263821-10	2006	Furthermore, imatinib (10 microM for 48 h) attenuated T cell factor/lymphoid enhancer factor activity, reduced cyclin D1 levels and dose-dependently suppressed thyrocyte proliferation by half without affecting apoptosis.	Imatinib Mesylate	13-21	cyclin D1	Homo sapiens	111-120
16173047-0	2006	8-chloroadenosine induced HL-60 cell growth inhibition, differentiation, and G(0)/G(1) arrest involves attenuated cyclin D1 and telomerase and up-regulated p21(WAF1/CIP1).	8-chloroadenosine	0-17	cyclin D1	Homo sapiens	114-138
17357503-4	2006	QRT-PCR showed that the target gene cyclin D1 mRNA expression was gradually decreased with the dosage of aspirin.	Aspirin	105-112	cyclin D1	Homo sapiens	36-45
16173047-4	2006	The expressions of cyclin D1 and c-myc in HL-60 are suppressed by 8-chloroadenosine, whereas the cyclin-dependent kinases inhibitor p21(WAF1/CIP1) is up-regulated.	8-chloroadenosine	66-83	cyclin D1	Homo sapiens	19-28
16173047-7	2006	Therefore, anti-proliferation of HL-60 cells by 8-chloroadenosine involves coordination of cyclin D1 suppression, reduction of telomerase activity, and up-regulation of p21(WAF1/CIP1) that arrest cell-cycle progression at G(0)/G(1) phase and terminate cell differentiation.	8-chloroadenosine	48-65	cyclin D1	Homo sapiens	91-100
17329956-0	2006	PKC pathway and ERK/MAPK pathway are required for induction of cyclin D1 and p21Waf1 during 12-o-tetradecanoylphorbol 13-acetate-induced differentiation of myeloleukemia cells.	Tetradecanoylphorbol Acetate	92-128	cyclin D1	Homo sapiens	63-72
17329956-1	2006	Treatment of human promyelocytic leukemia cell HL60 with 12-o-tetradecanoylphorbol 13-acetate (TPA) induces growth arrest, differentiation towards the monocyte/macrophage lineage, and expression of cell cycle-regulating genes cyclin D1 and p21Waf1.	Tetradecanoylphorbol Acetate	57-93	cyclin D1	Homo sapiens	226-235
17329956-4	2006	Induction of cyclin D1 expression in TPA-treated HL60 cells was inhibited with protein kinase C (PKC) inhibitor bisindolylmaleimide I and mitogen activated protein kinase kinase (MEK) inhibitor PD98059.	bisindolylmaleimide I	112-133	cyclin D1	Homo sapiens	13-22
17329956-1	2006	Treatment of human promyelocytic leukemia cell HL60 with 12-o-tetradecanoylphorbol 13-acetate (TPA) induces growth arrest, differentiation towards the monocyte/macrophage lineage, and expression of cell cycle-regulating genes cyclin D1 and p21Waf1.	Tetradecanoylphorbol Acetate	95-98	cyclin D1	Homo sapiens	226-235
17329956-4	2006	Induction of cyclin D1 expression in TPA-treated HL60 cells was inhibited with protein kinase C (PKC) inhibitor bisindolylmaleimide I and mitogen activated protein kinase kinase (MEK) inhibitor PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	194-201	cyclin D1	Homo sapiens	13-22
17329956-6	2006	Thus, cyclin D1 and p21Waf1 expressions are considered to be induced via PKC and extracellular signal-regulated kinase/mitogen-activated protein kinase (MAPK/ERK) pathways in TPA-treated HL60 cells.	Tetradecanoylphorbol Acetate	175-178	cyclin D1	Homo sapiens	6-15
17329956-3	2006	Secondly, we demonstrated the signal transduction pathways of cyclin D1 and p21Waf1 expressions in TPA-treated HL60 cells.	Tetradecanoylphorbol Acetate	99-102	cyclin D1	Homo sapiens	62-71
17329956-4	2006	Induction of cyclin D1 expression in TPA-treated HL60 cells was inhibited with protein kinase C (PKC) inhibitor bisindolylmaleimide I and mitogen activated protein kinase kinase (MEK) inhibitor PD98059.	Tetradecanoylphorbol Acetate	37-40	cyclin D1	Homo sapiens	13-22
16322307-7	2005	Mechanistic studies revealed that silibinin induces Kip1/p27 but decreases cyclin D1, cyclin D3, cyclin E, cyclin-dependent kinase (CDK)-2, and CDK4 levels in both cell lines.	Silybin	34-43	cyclin D1	Homo sapiens	75-84
16267832-10	2006	Cells exposed to 17-AAG and LY294002 displayed a significant reduction in cell-cycle regulatory proteins, such as retinoblastoma (Rb), cyclin dependent kinase (CDK)4, CDK6, cyclin D1, and cyclin D3.	tanespimycin	17-23	cyclin D1	Homo sapiens	173-182
16267832-10	2006	Cells exposed to 17-AAG and LY294002 displayed a significant reduction in cell-cycle regulatory proteins, such as retinoblastoma (Rb), cyclin dependent kinase (CDK)4, CDK6, cyclin D1, and cyclin D3.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	cyclin D1	Homo sapiens	173-182
16120828-7	2005	In agreement with these observations, EGF and SB203580 increased expression of the G1-phase-specific gene cyclin-D1 (CCND1) and SB203580 downmodulated its inhibitor p21 (CDKN1A).	SB 203580	46-54	cyclin D1	Homo sapiens	106-115
16120828-7	2005	In agreement with these observations, EGF and SB203580 increased expression of the G1-phase-specific gene cyclin-D1 (CCND1) and SB203580 downmodulated its inhibitor p21 (CDKN1A).	SB 203580	46-54	cyclin D1	Homo sapiens	117-122
16322400-9	2005	At a dose of 5 mM, LiCl significantly increased the proliferative potency of thyrocytes, which appeared to be mediated by beta-catenin, since nuclear beta-catenin stimulated T-cell factor/lymphoid enhancer factor (TCF/LEF)-mediated transcription and upregulated downstream targets like cyclin D1.	Lithium Chloride	19-23	cyclin D1	Homo sapiens	286-295
16322332-8	2005	Although TNFalpha was poorly effective in increasing cyclin D1 expression, NF-kappaB blockade by the specific inhibitor BAY11-7082 reduced FCS-stimulated cyclin D1 by about 60%.	3-(4-methylphenylsulfonyl)-2-propenenitrile	120-130	cyclin D1	Homo sapiens	53-62
16322332-8	2005	Although TNFalpha was poorly effective in increasing cyclin D1 expression, NF-kappaB blockade by the specific inhibitor BAY11-7082 reduced FCS-stimulated cyclin D1 by about 60%.	3-(4-methylphenylsulfonyl)-2-propenenitrile	120-130	cyclin D1	Homo sapiens	154-163
16322332-9	2005	Finally, the inhibitory effects of CaR and BAY11-7082 on cyclin D1 expression were not additive - by blocking NF-kappaB CaR activation did not induce a further reduction in cyclin D1 levels.	3-(4-methylphenylsulfonyl)-2-propenenitrile	43-53	cyclin D1	Homo sapiens	57-66
16149045-5	2005	Nicotine administration (10(-6) M) stimulated cell cycle entry marked by increased DNA synthesis, PCNA and cyclin D1 production, and increased cell division.	Nicotine	0-8	cyclin D1	Homo sapiens	107-116
16314636-2	2005	The rexinoid, bexarotene, represses cyclin D1 and EGFR expression in vitro.	Bexarotene	14-24	cyclin D1	Homo sapiens	36-45
16314636-2	2005	The rexinoid, bexarotene, represses cyclin D1 and EGFR expression in vitro.	rexinoid	4-12	cyclin D1	Homo sapiens	36-45
16314517-6	2005	We further show that the transcriptional regulation of cyclin D1 and cell cycle control by TFII-I are dependent on its tyrosine phosphorylation at positions 248 and 611, sites required for its growth signal-mediated transcriptional activity.	Tyrosine	119-127	cyclin D1	Homo sapiens	55-64
16288056-8	2005	Treatment of HT29 human colon cancer cells with EGCG (12.5 or 20 micromol/L at different times) also increased protein levels of E-cadherin by 27% to 58%, induced the translocation of beta-catenin from nucleus to cytoplasm and plasma membrane, and decreased c-Myc and cyclin D1 (20 micromol/L EGCG for 24 hours).	epigallocatechin gallate	48-52	cyclin D1	Homo sapiens	268-277
16382042-4	2005	Sulindac sulfone was consistently more potent than the sulfide metabolite in all analyses, significantly decreasing the expression of total cellular beta-catenin (50% of control), pro-caspase 3 (49%), cyclin D1 (51%), and PPARdelta (65%) in SW480 cells.	sulindac sulfone	0-16	cyclin D1	Homo sapiens	201-210
16382042-4	2005	Sulindac sulfone was consistently more potent than the sulfide metabolite in all analyses, significantly decreasing the expression of total cellular beta-catenin (50% of control), pro-caspase 3 (49%), cyclin D1 (51%), and PPARdelta (65%) in SW480 cells.	Sulfides	55-62	cyclin D1	Homo sapiens	201-210
16267018-9	2005	Inhibition of MAPK pathway with either the MEK1 inhibitor PD98059 or a dominant-negative Ras mutant, RasN17, abolished bombesin-induced cyclin D1 activation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	58-65	cyclin D1	Homo sapiens	136-145
16153639-5	2005	DIF-1 induced cyclin D1 degradation, but this effect was prevented by treatment with lithium chloride and SB216763, the inhibitors of glycogen synthase kinase-3beta (GSK-3beta).	Lithium Chloride	85-101	cyclin D1	Homo sapiens	14-23
16153639-5	2005	DIF-1 induced cyclin D1 degradation, but this effect was prevented by treatment with lithium chloride and SB216763, the inhibitors of glycogen synthase kinase-3beta (GSK-3beta).	SB 216763	106-114	cyclin D1	Homo sapiens	14-23
16283521-15	2005	Furthermore, exposure of cells to NaAsO2 resulted in a significant inhibition of expression of the cell cycle and growth regulating gene, cyclin D1.	sodium arsenite	34-40	cyclin D1	Homo sapiens	138-147
16283521-17	2005	Transfection of cells with SiRNA specifically targeting eIF4E gene expression resulted in a significant inhibition of cyclin D1 gene suggesting that the observed inhibition of cyclin D1 gene in the NaAsO2-treated cells is most likely mediated through inhibition of eIF4E gene.	sodium arsenite	198-204	cyclin D1	Homo sapiens	118-127
16283521-17	2005	Transfection of cells with SiRNA specifically targeting eIF4E gene expression resulted in a significant inhibition of cyclin D1 gene suggesting that the observed inhibition of cyclin D1 gene in the NaAsO2-treated cells is most likely mediated through inhibition of eIF4E gene.	sodium arsenite	198-204	cyclin D1	Homo sapiens	176-185
16283521-18	2005	Taken together, our results indicate that the exposure of cells to NaAsO2 resulted in cytotoxicity and cell death, at least in part, due to the inhibition of eIF4E gene expression leading to diminished cellular levels of critical genes such as cyclin D1.	sodium arsenite	67-73	cyclin D1	Homo sapiens	244-253
15936839-3	2005	Firstly, we found a c-Jun/Jun B heterodimer regulated synchronously and directly cyclin D1 and p16 in the Tet-on-LMP1-HNE2 cell line, in which LMP1 expression is regulated by Tet-on system.	tetramethylenedisulfotetramine	106-109	cyclin D1	Homo sapiens	81-90
15936839-3	2005	Firstly, we found a c-Jun/Jun B heterodimer regulated synchronously and directly cyclin D1 and p16 in the Tet-on-LMP1-HNE2 cell line, in which LMP1 expression is regulated by Tet-on system.	tetramethylenedisulfotetramine	175-178	cyclin D1	Homo sapiens	81-90
16230390-0	2005	Cyclin D1 induction through IkappaB kinase beta/nuclear factor-kappaB pathway is responsible for arsenite-induced increased cell cycle G1-S phase transition in human keratinocytes.	arsenite	97-105	cyclin D1	Homo sapiens	0-9
16230390-4	2005	Further studies found that arsenite exposure was able to induce cyclin D1 expression.	arsenite	27-35	cyclin D1	Homo sapiens	64-73
16230390-5	2005	The induction of cyclin D1 by arsenite required nuclear factor-kappaB (NF-kappaB) activation, because the inhibition of IkappaB phosphorylation by overexpression of the dominant-negative mutant, IKKbeta-KM, impaired arsenite-induced cyclin D1 expression and G1-S transition.	arsenite	30-38	cyclin D1	Homo sapiens	17-26
16230390-5	2005	The induction of cyclin D1 by arsenite required nuclear factor-kappaB (NF-kappaB) activation, because the inhibition of IkappaB phosphorylation by overexpression of the dominant-negative mutant, IKKbeta-KM, impaired arsenite-induced cyclin D1 expression and G1-S transition.	arsenite	30-38	cyclin D1	Homo sapiens	233-242
16230390-5	2005	The induction of cyclin D1 by arsenite required nuclear factor-kappaB (NF-kappaB) activation, because the inhibition of IkappaB phosphorylation by overexpression of the dominant-negative mutant, IKKbeta-KM, impaired arsenite-induced cyclin D1 expression and G1-S transition.	arsenite	216-224	cyclin D1	Homo sapiens	17-26
16230390-7	2005	In addition, knockdown of cyclin D1 expression using cyclin D1-specific small interference RNA significantly blocked arsenite-induced cell cycle progression in HaCat cells.	arsenite	117-125	cyclin D1	Homo sapiens	26-35
16230390-7	2005	In addition, knockdown of cyclin D1 expression using cyclin D1-specific small interference RNA significantly blocked arsenite-induced cell cycle progression in HaCat cells.	arsenite	117-125	cyclin D1	Homo sapiens	53-62
16230390-8	2005	Taken together, our results show that arsenite-induced cell cycle from G(1) to S phase transition is through IKKbeta/NF-kappaB/cyclin D1-dependent pathway.	arsenite	38-46	cyclin D1	Homo sapiens	127-136
16317137-8	2005	Fisetin decreased the activities of cyclin-dependent kinases (CDK)2 and CDK4; these effects were likely attributable to decreases in the levels of cyclin E and D1 and an increase in p21(CIP1/WAF1) levels (P &lt; 0.05).	fisetin	0-7	cyclin D1	Homo sapiens	147-162
16123159-0	2005	Medroxyprogesterone acetate induces cell proliferation through up-regulation of cyclin D1 expression via phosphatidylinositol 3-kinase/Akt/nuclear factor-kappaB cascade in human breast cancer cells.	Medroxyprogesterone Acetate	0-27	cyclin D1	Homo sapiens	80-89
16123159-4	2005	MPA induced cyclin D1 expression (3.3-fold induction), and RU486, a selective PR antagonist, blocked the MPA-induced cell proliferation and cyclin D1 expression (23% inhibition).	Mifepristone	59-64	cyclin D1	Homo sapiens	140-149
16123159-9	2005	MPA induced the transient phosphorylation of Akt (2.7-fold induction at 5 min), and treatment with PI3K inhibitor (wortmannin) attenuated the MPA-induced up-regulation of cyclin D1 expression (40% inhibition) and cell proliferation (40% inhibition).	Wortmannin	115-125	cyclin D1	Homo sapiens	171-180
16123159-11	2005	Treatment with an IkappaBalpha phosphorylation inhibitor (BAY 11-7085) or a specific NFkappaB nuclear translocation inhibitor (SN-50) attenuated the MPA-induced up-regulation of both cyclin D1 expression (80 and 50% inhibition, respectively) and cell proliferation (55 and 34% inhibition, respectively).	BAY 11-7085	58-69	cyclin D1	Homo sapiens	183-192
16123159-11	2005	Treatment with an IkappaBalpha phosphorylation inhibitor (BAY 11-7085) or a specific NFkappaB nuclear translocation inhibitor (SN-50) attenuated the MPA-induced up-regulation of both cyclin D1 expression (80 and 50% inhibition, respectively) and cell proliferation (55 and 34% inhibition, respectively).	SN-50	127-132	cyclin D1	Homo sapiens	183-192
15936818-0	2005	Increase in Ara-C cytotoxicity in the presence of valproate, a histone deacetylase inhibitor, is associated with the concurrent expression of cyclin D1 and p27(Kip 1) in acute myeloblastic leukemia cells.	Cytarabine	12-17	cyclin D1	Homo sapiens	142-151
15936818-0	2005	Increase in Ara-C cytotoxicity in the presence of valproate, a histone deacetylase inhibitor, is associated with the concurrent expression of cyclin D1 and p27(Kip 1) in acute myeloblastic leukemia cells.	Valproic Acid	50-59	cyclin D1	Homo sapiens	142-151
15936818-4	2005	Valproate induced a clear G1 phase arrest and up-regulated cyclin D1 expression in the presence of Ara-C and etoposide.	Valproic Acid	0-9	cyclin D1	Homo sapiens	59-68
15936818-4	2005	Valproate induced a clear G1 phase arrest and up-regulated cyclin D1 expression in the presence of Ara-C and etoposide.	Cytarabine	99-104	cyclin D1	Homo sapiens	59-68
15936818-4	2005	Valproate induced a clear G1 phase arrest and up-regulated cyclin D1 expression in the presence of Ara-C and etoposide.	Etoposide	109-118	cyclin D1	Homo sapiens	59-68
16230611-4	2005	Dizocilpine reduces the phosphorylation of cAMP-responsive element binding protein, suppresses the expression of cyclin D1, up-regulates the cell cycle regulators and tumor suppressor proteins p21 and p53, and increases the number of lung adenocarcinoma cells in the G(2) and S phases of the cell cycle.	Dizocilpine Maleate	0-11	cyclin D1	Homo sapiens	113-122
16370310-0	2005	Role of cyclinD1 and CDK4 in the carcinogenesis induced by silica.	Silicon Dioxide	59-65	cyclin D1	Homo sapiens	8-16
16370310-1	2005	OBJECTIVE: To study the role of cyclinD1 and CDK4 in malignant transformation of human fetal lung diploid fibroblast cell line (2BS) induced by silica.	Silicon Dioxide	144-150	cyclin D1	Homo sapiens	32-40
16370310-7	2005	Compared with malignant transformed cells induced by silica, cells transfected with antisense pXJ41-cyclinD1 and pXJ41-CDK4 showed obviously reduced growth rates.	Silicon Dioxide	53-59	cyclin D1	Homo sapiens	100-108
16173963-7	2005	BAY 11-7082- and curcumin-induced cell death was associated with downregulation of Bcl-xL, cyclin D1, XIAP and c-FLIP, followed by caspase-8, poly(ADP-ribose) polymerase cleavage and activation.	Curcumin	17-25	cyclin D1	Homo sapiens	91-100
16173963-7	2005	BAY 11-7082- and curcumin-induced cell death was associated with downregulation of Bcl-xL, cyclin D1, XIAP and c-FLIP, followed by caspase-8, poly(ADP-ribose) polymerase cleavage and activation.	3-(4-methylphenylsulfonyl)-2-propenenitrile	0-11	cyclin D1	Homo sapiens	91-100
16219581-2	2005	The mTOR inhibitor, rapamycin, inhibited proliferation in three mantle cell lymphoma (MCL) cell lines and reduced cyclin D3 expression while cyclin D1 levels remained unchanged.	Sirolimus	20-29	cyclin D1	Homo sapiens	141-150
16142413-0	2005	The chlorophyllin-induced cell cycle arrest and apoptosis in human breast cancer MCF-7 cells is associated with ERK deactivation and Cyclin D1 depletion.	chlorophyllin	4-17	cyclin D1	Homo sapiens	133-142
16051194-7	2005	In addition, the down-regulation of checkpoint protein cyclin D1 and c-myc by thio-Cl-IB-MECA was well correlated with the arrest of cell cycle transition of G1 to S phase.	thio-cl	78-85	cyclin D1	Homo sapiens	55-64
16128579-2	2005	Antizyme has the ability to bind and inhibit the enzyme ornithine decarboxylase (ODC), targeting it for degradation at the proteasome; antizyme is also known to affect the transport of polyamines and interact with the antizyme inhibitor protein (AZI), as well as the cell-cycle protein cyclin D1.	Polyamines	185-195	cyclin D1	Homo sapiens	286-295
15890789-4	2005	Hyperexpression of FAK autophosphorylation site (Tyr-397) mutant (MT-FAK) reduced FAK phosphorylation at Tyr-397 in proliferating cells and was accompanied by reduction of cyclin D1 and increase of myogenin expression.	Tyrosine	49-52	cyclin D1	Homo sapiens	172-181
15890789-4	2005	Hyperexpression of FAK autophosphorylation site (Tyr-397) mutant (MT-FAK) reduced FAK phosphorylation at Tyr-397 in proliferating cells and was accompanied by reduction of cyclin D1 and increase of myogenin expression.	Tyrosine	105-108	cyclin D1	Homo sapiens	172-181
16082258-0	2005	A simple antigen retrieval method for the optimal demonstration of cyclin-D1 overexpression in formalin-fixed paraffin-embedded cases of mantle cell lymphoma.	Formaldehyde	95-103	cyclin D1	Homo sapiens	67-76
16082258-0	2005	A simple antigen retrieval method for the optimal demonstration of cyclin-D1 overexpression in formalin-fixed paraffin-embedded cases of mantle cell lymphoma.	Paraffin	110-118	cyclin D1	Homo sapiens	67-76
16082258-3	2005	However, demonstration of cyclin D1 by immunohistochemistry on formalin-fixed, paraffin-embedded tissue is often fraught with technical difficulties, chiefly poor staining intensity largely due to insufficient antigen retrieval.	Formaldehyde	63-71	cyclin D1	Homo sapiens	26-35
16082258-3	2005	However, demonstration of cyclin D1 by immunohistochemistry on formalin-fixed, paraffin-embedded tissue is often fraught with technical difficulties, chiefly poor staining intensity largely due to insufficient antigen retrieval.	Paraffin	79-87	cyclin D1	Homo sapiens	26-35
16023083-3	2005	Since MCL cells are known to overexpress NF-kappaB regulated gene products (including cyclin D1), we used curcumin, a pharmacologically safe agent, to target NF-kappaB in a variety of MCL cell lines.	Curcumin	106-114	cyclin D1	Homo sapiens	86-95
16140974-0	2005	Adverse effect of adjuvant tamoxifen in premenopausal breast cancer with cyclin D1 gene amplification.	Tamoxifen	27-36	cyclin D1	Homo sapiens	73-82
16140974-6	2005	Consequently, a highly significant interaction between tamoxifen treatment and CCND1 amplification could be shown regarding both recurrence-free survival (RR, 6.38; 95% CI, 2.29-17.78; P &lt; 0.001) and overall survival (RR, 5.34; 95% CI, 1.84-15.51; P = 0.002), suggesting an agonistic effect of tamoxifen in ER-positive tumors.	Tamoxifen	55-64	cyclin D1	Homo sapiens	79-84
16140974-6	2005	Consequently, a highly significant interaction between tamoxifen treatment and CCND1 amplification could be shown regarding both recurrence-free survival (RR, 6.38; 95% CI, 2.29-17.78; P &lt; 0.001) and overall survival (RR, 5.34; 95% CI, 1.84-15.51; P = 0.002), suggesting an agonistic effect of tamoxifen in ER-positive tumors.	Tamoxifen	297-306	cyclin D1	Homo sapiens	79-84
16140974-8	2005	In summary, our data implicate that despite a significant correlation to cyclin D1 protein expression, amplification status of the CCND1 gene seems a strong independent predictor of tamoxifen response, and possibly agonism, in premenopausal breast cancer.	Tamoxifen	182-191	cyclin D1	Homo sapiens	131-136
16153458-9	2005	Our results suggest that serine 795 but not serine 780 is the preferred phosphorylation site induced by cyclin D1.	Serine	25-31	cyclin D1	Homo sapiens	104-113
16005468-4	2005	Microarray profiling of fas-resistant versus sensitive cells identified a set of genes including STATs, caspase 1, cyclin D1, Bcl-xL, VDAC2, and BAD.	ammonium ferrous sulfate	24-27	cyclin D1	Homo sapiens	115-124
15647388-5	2005	Also, EGCG dose and time dependently decreased levels of phospho-ERK1/2, Cdk2, and cyclin D(1) proteins, reduced Cdk2 activity, and increased levels of G(0)/G(1) growth arrest, p21(waf/cip), and p27(kip1), but not p18(ink), proteins and their associations to Cdk2.	epigallocatechin gallate	6-10	cyclin D1	Homo sapiens	83-94
16243823-5	2005	Curcumin also suppressed the paclitaxel-induced expression of antiapoptotic (XIAP, IAP-1, IAP-2, Bcl-2, and Bcl-xL), proliferative (cyclooxygenase 2, c-Myc, and cyclin D1), and metastatic proteins (vascular endothelial growth factor, matrix metalloproteinase-9, and intercellular adhesion molecule-1).	Curcumin	0-8	cyclin D1	Homo sapiens	161-170
16243823-5	2005	Curcumin also suppressed the paclitaxel-induced expression of antiapoptotic (XIAP, IAP-1, IAP-2, Bcl-2, and Bcl-xL), proliferative (cyclooxygenase 2, c-Myc, and cyclin D1), and metastatic proteins (vascular endothelial growth factor, matrix metalloproteinase-9, and intercellular adhesion molecule-1).	Paclitaxel	29-39	cyclin D1	Homo sapiens	161-170
15951563-8	2005	The bromo domain and cysteine- and histidine-rich domains of p300 were required for repression by cyclin D1.	Cysteine	21-29	cyclin D1	Homo sapiens	98-107
15951563-8	2005	The bromo domain and cysteine- and histidine-rich domains of p300 were required for repression by cyclin D1.	Histidine	35-44	cyclin D1	Homo sapiens	98-107
16115953-0	2005	Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell line.	Cisplatin	81-90	cyclin D1	Homo sapiens	18-27
16115953-7	2005	Moreover, cyclin D1-overexpressing cells exhibited significantly reduced chemosensitivity and a higher survival rate upon cisplatin treatment, as determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and clonogenic assays, respectively.	Cisplatin	122-131	cyclin D1	Homo sapiens	10-19
16115953-7	2005	Moreover, cyclin D1-overexpressing cells exhibited significantly reduced chemosensitivity and a higher survival rate upon cisplatin treatment, as determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and clonogenic assays, respectively.	thiazolyl blue	160-220	cyclin D1	Homo sapiens	10-19
16115953-8	2005	Although overexpression of cyclin D1 rendered cells more resistant to cisplatin-induced apoptosis, siRNA-directed suppression of cyclin D1 expression resulted in enhanced susceptibility to cisplatin-mediated apoptosis.	Cisplatin	70-79	cyclin D1	Homo sapiens	27-36
16115953-8	2005	Although overexpression of cyclin D1 rendered cells more resistant to cisplatin-induced apoptosis, siRNA-directed suppression of cyclin D1 expression resulted in enhanced susceptibility to cisplatin-mediated apoptosis.	Cisplatin	189-198	cyclin D1	Homo sapiens	129-138
16115953-9	2005	The attenuation of cisplatin-induced cell death in cyclin D1-overexpressing cells was correlated with the up-regulation of nuclear factor-kappaB activity and maintenance of bcl-2 and bcl-xl protein levels.	Cisplatin	19-28	cyclin D1	Homo sapiens	51-60
15962287-6	2005	Treatment with PDGF induced the cell cycle transition from the G0/G1 phase to the S phase, the elevated expression of cyclin D1, and the phosphorylation of Rb, which were prevented by a pretreatment with SP600125.	pyrazolanthrone	204-212	cyclin D1	Homo sapiens	118-127
15845652-2	2005	We hypothesized that the direction of the association between the (CCND1) G870A-polymorphism and breast cancer risk may be modified by dietary and genetic factors influencing the oxidant-antioxidant balance, such as a dietary pattern with a high intake of n-6 fatty acids and a low intake of n-3 fatty acids, or a genetic profile that is deficient in glutathione S-transferases.	Fatty Acids, Omega-6	256-271	cyclin D1	Homo sapiens	67-72
15845652-2	2005	We hypothesized that the direction of the association between the (CCND1) G870A-polymorphism and breast cancer risk may be modified by dietary and genetic factors influencing the oxidant-antioxidant balance, such as a dietary pattern with a high intake of n-6 fatty acids and a low intake of n-3 fatty acids, or a genetic profile that is deficient in glutathione S-transferases.	Fatty Acids, Omega-3	292-307	cyclin D1	Homo sapiens	67-72
15923181-12	2005	Since phorbol ester enhanced cyclin D1 expression and subsequent G1-to-S-phase transition of endothelial cells, we suggest that the PKC-mediated exclusion of LIMK2 from the nucleus might be a mechanism to relieve suppression of cyclin D1 expression by LIMK2.	Phorbol Esters	6-19	cyclin D1	Homo sapiens	29-38
16383299-0	2005	[Detection of cyclin D1 mRNA by reverse transcription-polymerase chain reaction in paraffin-embedded tissues and its diagnostic significance for mantle cell lymphoma].	Paraffin	83-91	cyclin D1	Homo sapiens	14-23
16383299-1	2005	OBJECTIVE: To investigate the feasibility of detecting cyclin D1 mRNA in paraffin-embedded tissues by reverse transcriptase polymerase chain reaction (RT-PCR) and competitive RT-PCR and its diagnostic and differential diagnostic significance for mantle cell lymphoma (MCL).	Paraffin	73-81	cyclin D1	Homo sapiens	55-64
16383299-8	2005	(3) cyclin D1 mRNA was detected in 34 nodal mantle cell lymphoma cases by RT-PCR in paraffin-embedded tissues.	Paraffin	84-92	cyclin D1	Homo sapiens	4-13
16383299-12	2005	(4) Cyclin D1 mRNA overexpression was detected in 27 cases of nodal mantle cell lymphoma by competitive RT-PCR in paraffin-embedded tissues.	Paraffin	114-122	cyclin D1	Homo sapiens	4-13
16383299-15	2005	CONCLUSION: RT-PCR and competitive RT-PCR detection of cyclin D1 mRNA overexpression could be used for the diagnosis and differential diagnosis of mantle cell lymphoma in paraffin-embedded blocks.	Paraffin	171-179	cyclin D1	Homo sapiens	55-64
15897899-7	2005	NAC or rotenone reduced E2-induced cyclin D1 expression.	Rotenone	7-15	cyclin D1	Homo sapiens	35-44
15897899-8	2005	Furthermore, E2-induced binding of AP-1 and CREB to the TRE and CRE response sequences, respectively, in the promoter of cyclin D1 was inhibited by NAC or rotenone.	Rotenone	155-163	cyclin D1	Homo sapiens	121-130
15996662-7	2005	Transduction of p27(T187A) in breast cancer cells with a doxycycline-regulated adenovirus led to greater inhibition of proliferation, more extensive apoptosis, with a markedly reduced protein levels of cyclin E and increased accumulation of cyclin D1, compared with wild-type p27.	Doxycycline	57-68	cyclin D1	Homo sapiens	241-250
16024653-2	2005	We reported previously that all-trans-retinoic acid chemo-prevented carcinogenic transformation of human bronchial epithelial (HBE) cells through proteasomal degradation of cyclin D1.	Tretinoin	28-51	cyclin D1	Homo sapiens	173-182
16024653-5	2005	Retinoic acid decreased cyclin D1 and cyclin D3 protein expression.	Tretinoin	0-13	cyclin D1	Homo sapiens	24-33
16024653-8	2005	Threonine 286 (T286) mutation of cyclin D1 stabilized cyclin D1, but a homologous mutation of cyclin D3 affecting threonine 283 did not affect cyclin D3 stability, despite retinoic acid treatment.	Threonine	0-9	cyclin D1	Homo sapiens	33-42
16024653-8	2005	Threonine 286 (T286) mutation of cyclin D1 stabilized cyclin D1, but a homologous mutation of cyclin D3 affecting threonine 283 did not affect cyclin D3 stability, despite retinoic acid treatment.	Threonine	0-9	cyclin D1	Homo sapiens	54-63
16024653-9	2005	Lithium chloride and SB216763, both glycogen synthase kinase 3 (GSK3) inhibitors, inhibited retinoic acid repression of cyclin D1, but not cyclin D3 proteins.	Lithium Chloride	0-16	cyclin D1	Homo sapiens	120-129
16024653-9	2005	Lithium chloride and SB216763, both glycogen synthase kinase 3 (GSK3) inhibitors, inhibited retinoic acid repression of cyclin D1, but not cyclin D3 proteins.	SB 216763	21-29	cyclin D1	Homo sapiens	120-129
16024653-9	2005	Lithium chloride and SB216763, both glycogen synthase kinase 3 (GSK3) inhibitors, inhibited retinoic acid repression of cyclin D1, but not cyclin D3 proteins.	Tretinoin	92-105	cyclin D1	Homo sapiens	120-129
16024653-11	2005	Expression of cyclin D1 and cyclin D3 was deregulated in retinoic acid-resistant HBE cells, directly implicating these species in retinoic acid response.	Tretinoin	57-70	cyclin D1	Homo sapiens	14-23
16024653-11	2005	Expression of cyclin D1 and cyclin D3 was deregulated in retinoic acid-resistant HBE cells, directly implicating these species in retinoic acid response.	Tretinoin	130-143	cyclin D1	Homo sapiens	14-23
16024653-15	2005	Thus, retinoic acid repressed cyclin D1 and cyclin D3 through distinct mechanisms.	Tretinoin	6-19	cyclin D1	Homo sapiens	30-39
15955616-7	2005	Cyclin D(1) expression was found to be strong in patients with treated estradiol valerate.	Estradiol	71-89	cyclin D1	Homo sapiens	0-11
16053698-2	2005	Addition of the mGlu2/3 receptor antagonist LY341495 to the cultures reduced cell growth, expression of cyclin D1/2, and activation of the MAP kinase and phosphatidylinositol-3-kinase pathways.	LY 341495	44-52	cyclin D1	Homo sapiens	104-115
15958613-4	2005	Inhibition of active Ras by farnesylthiosalicylic acid led to attenuation of the Raf-MEK-ERK and phosphoinositide 3-kinase-Akt-glycogen synthase-3 (GSK-3) pathways, to reduction in cyclin D1, phospho-retinoblastoma, and E2F, and to increase in the cyclin-dependent kinase inhibitor p27 and in retinoblastoma-binding protein-1, an inhibitor of E2F transcriptional activity.	farnesylthiosalicylic acid	28-54	cyclin D1	Homo sapiens	181-190
15870875-0	2005	Curcumin decreases cell proliferation rates through BTG2-mediated cyclin D1 down-regulation in U937 cells.	Curcumin	0-8	cyclin D1	Homo sapiens	66-75
15870875-2	2005	It has been reported that curcumin-treated cells show decreased expression of cyclin D1, ultimately resulting in decreased cell growth rate.	Curcumin	26-34	cyclin D1	Homo sapiens	78-87
15870875-4	2005	However, the precise molecular mechanisms involving down-regulation of cyclin D1 by curcumin are not largely understood.	Curcumin	84-92	cyclin D1	Homo sapiens	71-80
15870875-5	2005	In this study we investigated the mechanisms of cyclin D1 down-regulation by curcumin in U937 cells.	Curcumin	77-85	cyclin D1	Homo sapiens	48-57
15870875-6	2005	Expressions of cyclin D1, particularly at protein and mRNA levels, were clearly decreased in curcumin-treated cells.	Curcumin	93-101	cyclin D1	Homo sapiens	15-24
15870875-8	2005	Treatment of curcumin increased expression of BTG2 mRNA, a member of anti-proliferative gene family and a negative transcriptional regulator of cyclin D1.	Curcumin	13-21	cyclin D1	Homo sapiens	144-153
15870875-12	2005	Moreover, the expression of cyclin D1 mRNA was dramatically decreased after co-treatment curcumin with NF-kappaB inhibitors.	Curcumin	89-97	cyclin D1	Homo sapiens	28-37
15870875-13	2005	The data presented here indicate that curcumin-induced down-regulation of cyclin D1 mRNA is mediated by induction of BTG2 as well as inhibition of nuclear translocation of NF-kappaB.	Curcumin	38-46	cyclin D1	Homo sapiens	74-83
16007395-5	2005	PGEP4-A induced not only Bcl-xL protein expression (as we had previously demonstrated in HepG2 cells) but also induced cyclin D1 protein expression in mouse primary hepatocytes as well as the phosphorylation of EGF-R and ERK.	pgep4-a	0-7	cyclin D1	Homo sapiens	119-128
15772290-8	2005	We found that endothelin-1 increased cyclin D1 protein, which was blocked by preincubation with the Src antagonist PP2 and with the protein kinase C antagonist bisindolylmaleimide I.	bisindolylmaleimide I	160-181	cyclin D1	Homo sapiens	37-46
15738001-0	2005	Curcumin selectively induces apoptosis in deregulated cyclin D1-expressed cells at G2 phase of cell cycle in a p53-dependent manner.	Curcumin	0-8	cyclin D1	Homo sapiens	54-63
15738001-2	2005	In asynchronous cultures, with time-lapse video-micrography in combination with quantitative fluorescence microscopy, we have demonstrated that curcumin induces apoptosis at G(2) phase of cell cycle in deregulated cyclin D1-expressed mammary epithelial carcinoma cells, leaving its normal counterpart unaffected.	Curcumin	144-152	cyclin D1	Homo sapiens	214-223
15738001-5	2005	On the other hand, curcumin reversibly inhibits normal mammary epithelial cell cycle progression by down-regulating cyclin D1 expression and blocking its association with Cdk4/Cdk6 as well as by inhibiting phosphorylation and inactivation of retinoblastoma protein.	Curcumin	19-27	cyclin D1	Homo sapiens	116-125
15738001-9	2005	Similarly, in ectopically overexpressed system, curcumin cannot down-regulate cyclin D1 and thus block cell cycle progression.	Curcumin	48-56	cyclin D1	Homo sapiens	78-87
16507390-8	2005	In HK-1 cells, the expression of the cell cycle regulatory protein, cyclin D1, was down regulated by incubation with 80 microM celecoxib for 24 hrs.	Celecoxib	127-136	cyclin D1	Homo sapiens	68-77
16155412-6	2005	Using a transfected COS-7 cell model system, we demonstrate that the activity of a cyclin D1 promoter-luciferase construct increased under hypoxic conditions or DFO treatment.	Deferoxamine	161-164	cyclin D1	Homo sapiens	83-92
16103104-5	2005	Using the syngeneic tumor model, BCL1, we have shown that timing of cyclophosphamide relative to mAb is critical to therapeutic outcome.	Cyclophosphamide	68-84	cyclin D1	Homo sapiens	33-37
15983389-2	2005	This study tested whether temsirolimus (previously known as CCI-779), an inhibitor of the mammalian target of rapamycin kinase that regulates cyclin D1 translation, could produce tumor responses in patients with MCL.	temsirolimus	26-38	cyclin D1	Homo sapiens	142-151
15983389-2	2005	This study tested whether temsirolimus (previously known as CCI-779), an inhibitor of the mammalian target of rapamycin kinase that regulates cyclin D1 translation, could produce tumor responses in patients with MCL.	temsirolimus	60-67	cyclin D1	Homo sapiens	142-151
16061635-8	2005	In chromatin immunoprecipitation assays, 17beta-estradiol (E2) enhanced ERalpha and cyclin D1 recruitment to an estrogen response element (ERE).	Estradiol	41-57	cyclin D1	Homo sapiens	84-93
15978052-0	2005	Antiproliferative activity of melatonin by transcriptional inhibition of cyclin D1 expression: a molecular basis for melatonin-induced oncostatic effects.	Melatonin	30-39	cyclin D1	Homo sapiens	73-82
15978052-0	2005	Antiproliferative activity of melatonin by transcriptional inhibition of cyclin D1 expression: a molecular basis for melatonin-induced oncostatic effects.	Melatonin	117-126	cyclin D1	Homo sapiens	73-82
15978052-3	2005	We found that cyclin D1 was one of the main downregulated genes by melatonin.	Melatonin	67-76	cyclin D1	Homo sapiens	14-23
15978052-4	2005	Validation experiments clearly confirm that in MCF-7 cells the estrogen-induced growth inhibitory activity of melatonin is consistently associated with inhibition of estrogen-elicited cyclin D1 induction.	Melatonin	110-119	cyclin D1	Homo sapiens	184-193
15978052-6	2005	Reporter gene assays indicate that the same portion of the cyclin D1 promoter which confers estrogen sensitivity, encompassing a potential cAMP responsive element binding site, is repressed by melatonin.	Cyclic AMP	139-143	cyclin D1	Homo sapiens	59-68
15978052-6	2005	Reporter gene assays indicate that the same portion of the cyclin D1 promoter which confers estrogen sensitivity, encompassing a potential cAMP responsive element binding site, is repressed by melatonin.	Melatonin	193-202	cyclin D1	Homo sapiens	59-68
15978052-7	2005	Transcriptional downregulation of cyclin D1 is the key molecular event for melatonin"s antiproliferative activity, as this activity can be completely and selectively rescued by transient cyclin D1 overexpression.	Melatonin	75-84	cyclin D1	Homo sapiens	34-43
15978052-7	2005	Transcriptional downregulation of cyclin D1 is the key molecular event for melatonin"s antiproliferative activity, as this activity can be completely and selectively rescued by transient cyclin D1 overexpression.	Melatonin	75-84	cyclin D1	Homo sapiens	187-196
15978052-8	2005	Finally, we provide indirect evidence that the effect of melatonin on the cyclin D1 promoter is mediated by the c-jun and ATF-2 proteins, known to bind the minimal estrogen-sensitive cyclin D1 promoter element.	Melatonin	57-66	cyclin D1	Homo sapiens	74-83
15978052-8	2005	Finally, we provide indirect evidence that the effect of melatonin on the cyclin D1 promoter is mediated by the c-jun and ATF-2 proteins, known to bind the minimal estrogen-sensitive cyclin D1 promoter element.	Melatonin	57-66	cyclin D1	Homo sapiens	183-192
15845746-0	2005	Progesterone inhibits the estrogen-induced phosphoinositide 3-kinase--&gt;AKT--&gt;GSK-3beta--&gt;cyclin D1--&gt;pRB pathway to block uterine epithelial cell proliferation.	Progesterone	0-12	cyclin D1	Homo sapiens	98-107
15845746-7	2005	Inhibition of the GSK-3beta activity in P4-treated uteri by the specific inhibitor, LiCl, reversed the nuclear accumulation of cyclin D1 and in doing so, caused pRB phosphorylation and the induction of downstream genes, proliferating cell nuclear antigen and Ki67.	Lithium Chloride	84-88	cyclin D1	Homo sapiens	127-136
15845746-8	2005	Conversely, inhibition of phosphoinositide 3 kinase by LY294002 or Wortmanin reversed the E2-induced GSK-3beta Ser9 inhibitory phosphorylation and blocked nuclear accumulation of cyclin D1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	cyclin D1	Homo sapiens	179-188
15845746-8	2005	Conversely, inhibition of phosphoinositide 3 kinase by LY294002 or Wortmanin reversed the E2-induced GSK-3beta Ser9 inhibitory phosphorylation and blocked nuclear accumulation of cyclin D1.	Wortmannin	67-76	cyclin D1	Homo sapiens	179-188
16248432-2	2005	We studied the regulation of cyclinD1 by c-Jun/Jun B heterodimers by laser scanning confocal influorescence microscopy, Western blot, luciferase activity assay, super-EMSA and flow cytometry in the Tet-on-LMP1 HNE2 cell line, in which LMP1 expression was regulated by Tet-on system.	tetramethylenedisulfotetramine	198-201	cyclin D1	Homo sapiens	29-37
16248432-2	2005	We studied the regulation of cyclinD1 by c-Jun/Jun B heterodimers by laser scanning confocal influorescence microscopy, Western blot, luciferase activity assay, super-EMSA and flow cytometry in the Tet-on-LMP1 HNE2 cell line, in which LMP1 expression was regulated by Tet-on system.	tetramethylenedisulfotetramine	268-271	cyclin D1	Homo sapiens	29-37
16092977-9	2005	Taurine inhibited cyclin D1 expression and induced P21waf1 expression.	Taurine	0-7	cyclin D1	Homo sapiens	18-27
16092977-11	2005	CONCLUSIONS: Cyclin D1 and P21waf1 were cell cycle regulatory proteins in HSC, and taurine can inhibit the HSC cyclin D1 expression and stimulate P21waf1 expression, facilitate arresting cells in G0/G1 phase, and suppress cell proliferation.	Taurine	83-90	cyclin D1	Homo sapiens	111-120
15802527-2	2005	Immunoblot analysis demonstrates that R-etodolac induces apoptosis characterized by caspase-8, -9, and -3 and PARP (poly-ADP [adenosine diphosphate]-ribose polymerase) cleavage and down-regulation of cyclin D1 expression.	Etodolac	38-48	cyclin D1	Homo sapiens	200-209
15899904-3	2005	The expression of cyclin D1 and vascular endothelial growth factor was induced by PGE2 in LS-174T cells.	Dinoprostone	82-86	cyclin D1	Homo sapiens	18-27
15899904-4	2005	Moreover, PGE2 and mutated beta-catenin stimulated the transcription of cyclin D1 and vascular endothelial growth factor in a synergistic fashion.	Dinoprostone	10-14	cyclin D1	Homo sapiens	72-81
15863496-1	2005	Carbon monoxide (CO), one of the end products of heme oxygenase activity, inhibits smooth muscle proliferation by decreasing ERK1/2 phosphorylation and cyclin D1 expression, a signaling pathway that is known to be modulated by reactive oxygen species (ROS) in airway smooth muscle cells (ASMCs).	Carbon Monoxide	0-15	cyclin D1	Homo sapiens	152-161
15863496-1	2005	Carbon monoxide (CO), one of the end products of heme oxygenase activity, inhibits smooth muscle proliferation by decreasing ERK1/2 phosphorylation and cyclin D1 expression, a signaling pathway that is known to be modulated by reactive oxygen species (ROS) in airway smooth muscle cells (ASMCs).	Carbon Monoxide	17-19	cyclin D1	Homo sapiens	152-161
15863496-1	2005	Carbon monoxide (CO), one of the end products of heme oxygenase activity, inhibits smooth muscle proliferation by decreasing ERK1/2 phosphorylation and cyclin D1 expression, a signaling pathway that is known to be modulated by reactive oxygen species (ROS) in airway smooth muscle cells (ASMCs).	Reactive Oxygen Species	227-250	cyclin D1	Homo sapiens	152-161
15863496-4	2005	Here we show that a recently identified carbon monoxide-releasing molecule, [Ru(CO)3Cl2]2 (or CORM-2) 1) inhibits NAD(P)H oxidase cytochrome b558 activity, 2) increases oxidant production by the mitochondria, and 3) inhibits ASMC proliferation and phosphorylation of the ERK1/2 mitogen-activated protein kinase and expression of cyclin D1, two critical pathways involved in muscle proliferation.	Carbon Monoxide	40-55	cyclin D1	Homo sapiens	329-338
15863496-4	2005	Here we show that a recently identified carbon monoxide-releasing molecule, [Ru(CO)3Cl2]2 (or CORM-2) 1) inhibits NAD(P)H oxidase cytochrome b558 activity, 2) increases oxidant production by the mitochondria, and 3) inhibits ASMC proliferation and phosphorylation of the ERK1/2 mitogen-activated protein kinase and expression of cyclin D1, two critical pathways involved in muscle proliferation.	(co)3cl2	79-87	cyclin D1	Homo sapiens	329-338
15863496-4	2005	Here we show that a recently identified carbon monoxide-releasing molecule, [Ru(CO)3Cl2]2 (or CORM-2) 1) inhibits NAD(P)H oxidase cytochrome b558 activity, 2) increases oxidant production by the mitochondria, and 3) inhibits ASMC proliferation and phosphorylation of the ERK1/2 mitogen-activated protein kinase and expression of cyclin D1, two critical pathways involved in muscle proliferation.	asmc	225-229	cyclin D1	Homo sapiens	329-338
15863496-6	2005	Because both diphenylene iodinium or apocynin (inhibitors of NAD(P)H oxidase) and rotenone (a molecule that increases mitochondrial ROS production by blocking the respiratory chain) mimicked the effect of CORM-2 on cyclin D1 expression and ASMC proliferation, the antiproliferative effect of CORM-2 is probably related to inhibition of cytochromes on both NAD(P)H oxidase and the respiratory chain.	Rotenone	82-90	cyclin D1	Homo sapiens	215-224
15878868-7	2005	Exposure of cells to cadmium, as well as the specific silencing of eIF4E gene, also resulted in decreased cellular levels of cyclin D1, a critical cell cycle and growth regulating gene, suggesting that the observed inhibition of cyclin D1 gene expression in the cadmium-treated cells is most likely due to decreased cellular level of eIF4E.	Cadmium	21-28	cyclin D1	Homo sapiens	125-134
15878868-7	2005	Exposure of cells to cadmium, as well as the specific silencing of eIF4E gene, also resulted in decreased cellular levels of cyclin D1, a critical cell cycle and growth regulating gene, suggesting that the observed inhibition of cyclin D1 gene expression in the cadmium-treated cells is most likely due to decreased cellular level of eIF4E.	Cadmium	21-28	cyclin D1	Homo sapiens	229-238
15878868-7	2005	Exposure of cells to cadmium, as well as the specific silencing of eIF4E gene, also resulted in decreased cellular levels of cyclin D1, a critical cell cycle and growth regulating gene, suggesting that the observed inhibition of cyclin D1 gene expression in the cadmium-treated cells is most likely due to decreased cellular level of eIF4E.	Cadmium	262-269	cyclin D1	Homo sapiens	229-238
15878868-8	2005	Taken together, our results demonstrate that the exposure of cells to cadmium chloride resulted in cytotoxicity and cell death due to enhanced ubiquitination and consequent proteolysis of eIF4E protein, which in turn diminished cellular levels of critical genes such as cyclin D1.	Cadmium Chloride	70-86	cyclin D1	Homo sapiens	270-279
15883006-8	2005	The beta-catenin/Tcf transcriptional target gene cyclinD1 was downregulated by flavanone.	flavanone	79-88	cyclin D1	Homo sapiens	49-57
15976518-9	2005	Additionally, expression of cyclin D1 was significantly attenuated in cells co-treated with TNF and ethanol while each treatment alone had little effect on cyclin D1 expression.	Ethanol	100-107	cyclin D1	Homo sapiens	28-37
15911089-6	2005	RESULTS: With the bisulfite sequencing technique, we have studied the DNA methylation status of the core minimal cyclin D1 promoter containing Sp1- and CRE-binding sites.	hydrogen sulfite	18-27	cyclin D1	Homo sapiens	113-122
15893541-0	2005	Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFkappaB activation and cyclin D1 up-regulation.	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	28-74	cyclin D1	Homo sapiens	183-192
15893541-0	2005	Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFkappaB activation and cyclin D1 up-regulation.	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	76-79	cyclin D1	Homo sapiens	183-192
15890020-0	2005	Redox regulation of cell-cycle re-entry: cyclin D1 as a primary target for the mitogenic effects of reactive oxygen and nitrogen species.	reactive oxygen and nitrogen	100-128	cyclin D1	Homo sapiens	41-50
15868442-3	2005	Here we investigated the prognostic significance of cyclin D1 among 230 breast cancer patients randomised for tamoxifen, CMF chemotherapy and radiotherapy.	Tamoxifen	110-119	cyclin D1	Homo sapiens	52-61
15868442-9	2005	Among oestrogen receptor positive patients, those with moderate cyclin D1 expression significantly did benefit from tamoxifen treatment (RR = 0.42; 95% CI, 0.21-0.82) whereas those with weak or strong expression did not.	Tamoxifen	116-125	cyclin D1	Homo sapiens	64-73
15868442-10	2005	Therefore cyclin D1 might be a predictive marker for tamoxifen resistance.	Tamoxifen	53-62	cyclin D1	Homo sapiens	10-19
15368064-5	2005	Proliferation assays revealed an increase in resistance to cisplatin in cyclin D1 overexpressing cells.	Cisplatin	59-68	cyclin D1	Homo sapiens	72-81
15789403-5	2005	In this study, we show that the FGF2-mediated increase in bromodeoxyuridine (BrdU) incorporation into OL progenitors and mature OLs occurs concomitantly with increase in the levels of p21Cip1 and the formation of p21Cip1/cyclin D1/CDK4 ternary complexes.	Bromodeoxyuridine	58-75	cyclin D1	Homo sapiens	221-230
15789403-5	2005	In this study, we show that the FGF2-mediated increase in bromodeoxyuridine (BrdU) incorporation into OL progenitors and mature OLs occurs concomitantly with increase in the levels of p21Cip1 and the formation of p21Cip1/cyclin D1/CDK4 ternary complexes.	Bromodeoxyuridine	77-81	cyclin D1	Homo sapiens	221-230
15870300-4	2005	The hypoacetylation of H3 at the cyclin D1 promoter was reversed by treatment with trichostatin A (TSA), a histone deacetylase inhibitor, or by expression of TAF1 proteins that retain HAT activity.	trichostatin A	83-97	cyclin D1	Homo sapiens	33-42
15870300-4	2005	The hypoacetylation of H3 at the cyclin D1 promoter was reversed by treatment with trichostatin A (TSA), a histone deacetylase inhibitor, or by expression of TAF1 proteins that retain HAT activity.	trichostatin A	99-102	cyclin D1	Homo sapiens	33-42
15870300-6	2005	Treatment with TSA restored full activity to the cyclin D1-c-fos chimera at 39.5 degrees C. In vivo genomic footprinting experiments indicate that protein-DNA interactions at the Sp1 sites of the cyclin D1 promoter were compromised at 39.5 degrees C in ts13 cells.	trichostatin A	15-18	cyclin D1	Homo sapiens	49-58
15870300-6	2005	Treatment with TSA restored full activity to the cyclin D1-c-fos chimera at 39.5 degrees C. In vivo genomic footprinting experiments indicate that protein-DNA interactions at the Sp1 sites of the cyclin D1 promoter were compromised at 39.5 degrees C in ts13 cells.	trichostatin A	15-18	cyclin D1	Homo sapiens	196-205
15609335-11	2005	Furthermore, our data demonstrated that EGCG treatment resulted in a significant, dose-dependent decrease in cyclin D1 and cdk2 protein levels and induction of cyclin kinase inhibitors (ckis) p16INK4a, p21WAF1/CIP1 and p27KIP1.	epigallocatechin gallate	40-44	cyclin D1	Homo sapiens	109-118
15735756-0	2005	Phosphorylation of cyclin D1 at Thr 286 during S phase leads to its proteasomal degradation and allows efficient DNA synthesis.	Threonine	32-35	cyclin D1	Homo sapiens	19-28
15735756-6	2005	This decline depends upon Thr 286, since mutation of this site eliminates the normal pattern of cyclin D1 suppression during S phase.	Threonine	26-29	cyclin D1	Homo sapiens	96-105
16060994-2	2005	METHODS: Effects of gemcitabine combined with celecoxib on the proliferation in xenograft pancreatic carcinoma induced by SW1990 were investigated by immunohistochemistry of proliferating cell nuclear antigen (PCNA) and cyclin D1.	gemcitabine	20-31	cyclin D1	Homo sapiens	220-229
16060994-2	2005	METHODS: Effects of gemcitabine combined with celecoxib on the proliferation in xenograft pancreatic carcinoma induced by SW1990 were investigated by immunohistochemistry of proliferating cell nuclear antigen (PCNA) and cyclin D1.	Celecoxib	46-55	cyclin D1	Homo sapiens	220-229
16060994-8	2005	The expression of PCNA and cyclin D(1) was significantly reduced in gemcitabine group and can hardly be detected in combination group, but without significant change in celecoxib group.	gemcitabine	68-79	cyclin D1	Homo sapiens	27-38
15551329-6	2005	Induction of CCND1(tra) produced a 36-kDa protein, which led to a significant increase in the proportion of cells in S-phase, as detected by BrdU incorporation after 32 hr, compared to non-induced cells (p = 0.012).	Bromodeoxyuridine	141-145	cyclin D1	Homo sapiens	13-18
15814656-8	2005	Reporter assays indicated that both EGCG and Poly E inhibited the transcriptional activity of the activator protein 1 (AP-1), c-fos, nuclear factor kappaB, and cyclin D1 promoters.	epigallocatechin gallate	36-40	cyclin D1	Homo sapiens	160-169
15814656-8	2005	Reporter assays indicated that both EGCG and Poly E inhibited the transcriptional activity of the activator protein 1 (AP-1), c-fos, nuclear factor kappaB, and cyclin D1 promoters.	polyphenon E	45-51	cyclin D1	Homo sapiens	160-169
15653552-0	2005	Peroxisome proliferator-activated receptor gamma-independent ablation of cyclin D1 by thiazolidinediones and their derivatives in breast cancer cells.	Thiazolidinediones	86-104	cyclin D1	Homo sapiens	73-82
15653552-2	2005	We obtain evidence that the ability of high doses of troglitazone and ciglitazone to repress cyclin D1 is independent of PPARgamma activation.	Troglitazone	53-65	cyclin D1	Homo sapiens	93-102
15653552-2	2005	We obtain evidence that the ability of high doses of troglitazone and ciglitazone to repress cyclin D1 is independent of PPARgamma activation.	ciglitazone	70-81	cyclin D1	Homo sapiens	93-102
15653552-6	2005	Our data indicate that troglitazone- and Delta2-TG-induced cyclin D1 repression is mediated via proteasome-facilitated proteolysis because it is inhibited by different proteasome inhibitors, including N-carbobenzoxy-l-leucinyl-l-leucinyl-l-norleucinal (MG132), lactacystin, and epoxomicin, and is preceded by increased ubiquitination.	Troglitazone	23-35	cyclin D1	Homo sapiens	59-68
15653552-6	2005	Our data indicate that troglitazone- and Delta2-TG-induced cyclin D1 repression is mediated via proteasome-facilitated proteolysis because it is inhibited by different proteasome inhibitors, including N-carbobenzoxy-l-leucinyl-l-leucinyl-l-norleucinal (MG132), lactacystin, and epoxomicin, and is preceded by increased ubiquitination.	delta2-tg	41-50	cyclin D1	Homo sapiens	59-68
15653552-6	2005	Our data indicate that troglitazone- and Delta2-TG-induced cyclin D1 repression is mediated via proteasome-facilitated proteolysis because it is inhibited by different proteasome inhibitors, including N-carbobenzoxy-l-leucinyl-l-leucinyl-l-norleucinal (MG132), lactacystin, and epoxomicin, and is preceded by increased ubiquitination.	n-carbobenzoxy-l-leucinyl-l-leucinyl-l-norleucinal	201-251	cyclin D1	Homo sapiens	59-68
15653552-6	2005	Our data indicate that troglitazone- and Delta2-TG-induced cyclin D1 repression is mediated via proteasome-facilitated proteolysis because it is inhibited by different proteasome inhibitors, including N-carbobenzoxy-l-leucinyl-l-leucinyl-l-norleucinal (MG132), lactacystin, and epoxomicin, and is preceded by increased ubiquitination.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	253-258	cyclin D1	Homo sapiens	59-68
15653552-6	2005	Our data indicate that troglitazone- and Delta2-TG-induced cyclin D1 repression is mediated via proteasome-facilitated proteolysis because it is inhibited by different proteasome inhibitors, including N-carbobenzoxy-l-leucinyl-l-leucinyl-l-norleucinal (MG132), lactacystin, and epoxomicin, and is preceded by increased ubiquitination.	lactacystin	261-272	cyclin D1	Homo sapiens	59-68
15653552-6	2005	Our data indicate that troglitazone- and Delta2-TG-induced cyclin D1 repression is mediated via proteasome-facilitated proteolysis because it is inhibited by different proteasome inhibitors, including N-carbobenzoxy-l-leucinyl-l-leucinyl-l-norleucinal (MG132), lactacystin, and epoxomicin, and is preceded by increased ubiquitination.	epoxomicin	278-288	cyclin D1	Homo sapiens	59-68
15653552-7	2005	The dissociation of these two pharmacological activities (i.e., PPARgamma activation and cyclin D1 ablation) provides a molecular basis to use Delta2-TG as a scaffold to develop a novel class of cyclin D1-ablative agents.	delta2-tg	143-152	cyclin D1	Homo sapiens	89-98
15653552-7	2005	The dissociation of these two pharmacological activities (i.e., PPARgamma activation and cyclin D1 ablation) provides a molecular basis to use Delta2-TG as a scaffold to develop a novel class of cyclin D1-ablative agents.	delta2-tg	143-152	cyclin D1	Homo sapiens	195-204
15653552-9	2005	Among them, 5-[4-(6-allyoxy-2,5,7,8-tetramethyl-chroman-2-yl-methoxy)-benzylidene]-2,4-thiazolidinedione represents a structurally optimized agent with potency that is an order of magnitude higher than that of Delta2-TG in cyclin D1 repression and MCF-7 cell growth inhibition.	5-[4-(6-allyoxy-2,5,7,8-tetramethyl-chroman-2-yl-methoxy)-benzylidene]-2,4-thiazolidinedione	12-104	cyclin D1	Homo sapiens	223-232
15886844-0	2005	[The influence on expression of cyclin D1 by anti-sense oligonucleotide expression vector].	Oligonucleotides	56-71	cyclin D1	Homo sapiens	32-41
15634685-0	2005	Cyclin D1 and c-myc internal ribosome entry site (IRES)-dependent translation is regulated by AKT activity and enhanced by rapamycin through a p38 MAPK- and ERK-dependent pathway.	Sirolimus	123-132	cyclin D1	Homo sapiens	0-9
15634685-6	2005	Furthermore, we show that cyclin D1 and c-myc IRES function is enhanced following exposure to rapamycin and requires both p38 MAPK and RAF/MEK/ERK signaling, as specific inhibitors of these pathways reduce IRES-mediated translation and protein levels under conditions of quiescent AKT activity.	Sirolimus	94-103	cyclin D1	Homo sapiens	26-35
15781649-9	2005	Geldanamyin and PS-341 synergistically block NFkappaB activation, suppress Akt/PKB pathway, and down-regulate Bcl-XL, Bcl-2, cIAP-1, and cyclin D1 expression.	geldanamyin	0-11	cyclin D1	Homo sapiens	137-146
15781649-9	2005	Geldanamyin and PS-341 synergistically block NFkappaB activation, suppress Akt/PKB pathway, and down-regulate Bcl-XL, Bcl-2, cIAP-1, and cyclin D1 expression.	Bortezomib	16-22	cyclin D1	Homo sapiens	137-146
15486348-9	2005	In addition to curcumin reduction of the level of phosphorylated PPARgamma, inhibition of cyclin D1 expression played a major and significant role in curcumin stimulation of PPARgamma activity in Moser cells.	Curcumin	150-158	cyclin D1	Homo sapiens	90-99
15486348-10	2005	Taken together, our results demonstrated for the first time that curcumin activation of PPARgamma inhibited Moser cell growth and mediated the suppression of the gene expression of cyclin D1 and EGFR.	Curcumin	65-73	cyclin D1	Homo sapiens	181-190
15868934-4	2005	During the S-phase arrest, analysis of cell cycle regulatory molecules demonstrated that baicalein decreased the levels of cdk 4, cyclin B1 and cyclin D1.	baicalein	89-98	cyclin D1	Homo sapiens	144-153
15756026-11	2005	Treatment with celecoxib caused a marked decrease in amounts of cyclin D1 both in vitro and in vivo.	Celecoxib	15-24	cyclin D1	Homo sapiens	64-73
15309432-8	2005	RESULTS: Quercetin (5 microM) downregulated expression of cell cycle genes (for example CDC6, CDK4 and cyclin D1), downregulated cell proliferation and induced cell cycle arrest in Caco-2 cells.	Quercetin	9-18	cyclin D1	Homo sapiens	103-112
15765403-5	2005	RESULTS: We show that inhibition of MCT1 expression, and hence butyrate uptake, has profound inhibitory effects on the ability of butyrate to regulate expression of key target genes: p21waf1/cip1 (p21), intestinal alkaline phosphatase (IAP), and cyclin D1, and their associated processes of proliferation and differentiation.	Butyrates	130-138	cyclin D1	Homo sapiens	246-255
15703828-8	2005	Protein expression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4), but not p16INK4a Cdk inhibitor in the tumor was significantly reduced by vitamin K2 or K3 treatment, indicating that vitamins K2 and K3 may induce G1 arrest of cell cycle on PLC/PRF/5 cells in vivo.	Vitamin K 2	143-153	cyclin D1	Homo sapiens	22-31
15728509-0	2005	Pseudomonas aeruginosa lipopolysaccharide induction of keratinocyte proliferation, NF-kappa B, and cyclin D1 is inhibited by indomethacin.	Indomethacin	125-137	cyclin D1	Homo sapiens	99-108
15767558-9	2005	We found that cyclin D1, MMP-1, PI3KR1, and uPA were down-regulated by sulindac sulfide.	sulindac sulfide	71-87	cyclin D1	Homo sapiens	14-23
15784690-12	2005	In addition, AZT induced an upregulation of cyclin D1 accompanied by a downregulation of the cyclin D1-associated inhibitors P18 and P57, and the G(1)-S check point gene P21, the net effect of which would be to foster a cell progression into S phase.	Zidovudine	13-16	cyclin D1	Homo sapiens	44-53
15784690-12	2005	In addition, AZT induced an upregulation of cyclin D1 accompanied by a downregulation of the cyclin D1-associated inhibitors P18 and P57, and the G(1)-S check point gene P21, the net effect of which would be to foster a cell progression into S phase.	Zidovudine	13-16	cyclin D1	Homo sapiens	93-102
15842148-8	2005	Compared to the control group, intracellular Ca2+ concentration, Annexin V expression, phospatase and tensin homologe deleted on chromosome ten (PTEN) protein and expression gradually increased, while Cyclin D1 protein expression gradually decreased in the TPP treated groups along with the increasing of TPS concentration.	Phenol	257-260	cyclin D1	Homo sapiens	201-210
15713425-0	2005	Calcium and the replication of human vascular smooth muscle cells: studies on the activation and translocation of extracellular signal regulated kinase (ERK) and cyclin D1 expression.	Calcium	0-7	cyclin D1	Homo sapiens	162-171
15713425-2	2005	Human saphenous vein VSMCs (hVSMC) were incubated with 10 nM thapsigargin for 24 h followed by stimulation with fetal calf serum and the activation of ERK1/2 and cyclin D1 assessed by western blotting, the intracellular distribution of ERK1/2 using indirect immunofluorescence, the onset of S-phase with the incorporation of bromodeoxyuridine and sarcoplasmic reticular Ca2+ status using FURA-2.	Thapsigargin	61-73	cyclin D1	Homo sapiens	162-171
15713425-5	2005	S phase was delayed by 8 h by thapsigargin which co-incided with the recovery of cytosolic Ca2+ levels and cyclin D1 expression.	Thapsigargin	30-42	cyclin D1	Homo sapiens	107-116
15713425-6	2005	It is concluded that the inhibitory effect of thapsigargin (depletion of Ca2+ pools) on hVSMC replication is mediated through the inhibition of translocation of activated ERK1/2 to the nucleus and not to the phosphorylation of ERK, per se, which in turn prevents cyclin D1 expression and thus progression of the cell cycle.	Thapsigargin	46-58	cyclin D1	Homo sapiens	263-272
15589991-3	2005	Both serum starvation and application of mibefradil, a selective T-type calcium channel antagonist, resulted in a 50% decrease in the expression of alpha1G and alpha1H and a 700-900% increase in levels of cyclin D1 in U87MG and N1E-115 cells, respectively.	Mibefradil	41-51	cyclin D1	Homo sapiens	205-214
15805584-4	2005	The role of cyclin D1 overexpression in the pathogenesis of thyroid tumors is not known clearly; however, overexpression of this protein was reported in well-differentiated papillary cancers and in incidentally found metastasizing MCs.	mcs	231-234	cyclin D1	Homo sapiens	12-21
15805584-8	2005	The only cyclin D1-positive MC was multifocal (both lobes of the gland were affected).	Methylcholanthrene	28-30	cyclin D1	Homo sapiens	9-18
15645119-4	2005	In MKN-45, NS398 induced up-regulation of P27/Kip1 and down-regulation of COX-2, cyclin D1 and Skp2.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	11-16	cyclin D1	Homo sapiens	81-90
16075305-0	2005	Understanding and modulating cyclin-dependent kinase inhibitor specificity: molecular modeling and biochemical evaluation of pyrazolopyrimidinones as CDK2/cyclin A and CDK4/cyclin D1 inhibitors.	pyrazolopyrimidinones	125-146	cyclin D1	Homo sapiens	173-182
15691880-0	2005	Differential effects of 16alpha-hydroxyestrone and 2-methoxyestradiol on cyclin D1 involving the transcription factor ATF-2 in MCF-7 breast cancer cells.	16-hydroxyestrone	24-46	cyclin D1	Homo sapiens	73-82
15691880-0	2005	Differential effects of 16alpha-hydroxyestrone and 2-methoxyestradiol on cyclin D1 involving the transcription factor ATF-2 in MCF-7 breast cancer cells.	2-Methoxyestradiol	51-69	cyclin D1	Homo sapiens	73-82
15691880-5	2005	2-ME2 had no significant effect on cyclin D1; however, it prevented the accumulation of cyclin D1 in the presence of E2 and 16alpha-OHE1.	Estradiol	3-5	cyclin D1	Homo sapiens	88-97
15691880-5	2005	2-ME2 had no significant effect on cyclin D1; however, it prevented the accumulation of cyclin D1 in the presence of E2 and 16alpha-OHE1.	16-hydroxyestrone	124-136	cyclin D1	Homo sapiens	88-97
15691880-8	2005	Cyclin D1 transactivation was mediated by the cAMP response element (CRE) region, which binds activating transcription factor 2 (ATF-2).	Cyclic AMP	46-50	cyclin D1	Homo sapiens	0-9
15486045-7	2005	The PR antagonist RU486 also induced MAPK activation, increased cyclin D1 expression, and stimulated S phase entry, which was blocked by inhibition of either p42/p44 or p38 MAPKs, whereas proliferation induced by R5020 was sensitive only to p42/p44 MAPK inhibition.	Mifepristone	18-23	cyclin D1	Homo sapiens	64-73
15755876-6	2005	Trichostatin A inhibits cyclin D1 expression in a NF-kappaB-dependent manner in JB6 cells.	trichostatin A	0-14	cyclin D1	Homo sapiens	24-33
15755876-8	2005	Moreover, a chromatin immunoprecipitation assay shows that trichostatin A treatment inhibits endogenous cyclin D1 gene transcription by preventing p65 binding to the cyclin D1 promoter.	trichostatin A	59-73	cyclin D1	Homo sapiens	104-113
15755876-8	2005	Moreover, a chromatin immunoprecipitation assay shows that trichostatin A treatment inhibits endogenous cyclin D1 gene transcription by preventing p65 binding to the cyclin D1 promoter.	trichostatin A	59-73	cyclin D1	Homo sapiens	166-175
15755876-14	2005	Together, the results provide the first demonstration that HDAC inhibitor trichostatin A inhibits cyclin D1 gene transcription through targeting transcription factor NF-kappaB/p65 DNA binding.	trichostatin A	74-88	cyclin D1	Homo sapiens	98-107
15670636-4	2005	Resveratrol is able to induce S-phase cell arrest and this interference with the cell cycle is associated with an increase of cyclin E and cyclin A, a downregulation of cyclin D1, and no alteration in cyclin B1 and cdk 1 activation.	Resveratrol	0-11	cyclin D1	Homo sapiens	169-178
15486348-0	2005	Activation of PPAR{gamma} by curcumin inhibits Moser cell growth and mediates suppression of gene expression of cyclin D1 and EGFR.	Curcumin	29-37	cyclin D1	Homo sapiens	112-121
15486348-7	2005	Activation of PPARgamma mediated curcumin suppression of the expression of cyclin D1, a critical protein in the cell cycle, in Moser cells.	Curcumin	33-41	cyclin D1	Homo sapiens	75-84
15886844-4	2005	Induced by IPTG, the vector could express cyclin D1 protein in vitro.	Isopropyl Thiogalactoside	11-15	cyclin D1	Homo sapiens	42-51
15637397-5	2005	Retinoid-oral IEN studies (eg, of retinoic acid receptor-beta, p53, genetic instability, loss of heterozygosity, and cyclin D1) have advanced the overall understanding of the biology of intraepithelial carcinogenesis and of preventive agent molecular mechanisms and targets-important advances for monitoring preventive interventions and assessing cancer risk and pharmacogenomics.	Retinoids	0-8	cyclin D1	Homo sapiens	117-126
15695395-7	2005	Gel shift experiments revealed the activation of beta-catenin/T-cell-specific transcription factor (Tcf)/lymphoid enhancer factor-1 (Lef) transcriptional complex, evidenced by an increased binding of nuclear extracts to oligonucleotides containing the cyclin D1 Lef/Tcf site.	Oligonucleotides	220-236	cyclin D1	Homo sapiens	252-261
15695395-8	2005	beta-Catenin silencing through small interfering RNA and antisense oligonucleotides inhibited both the tPA-mediated cyclin D1 expression and cell proliferation.	Oligonucleotides	67-83	cyclin D1	Homo sapiens	116-125
15695403-2	2005	Here, we show that retinoic acid (RA) isomers significantly inhibit the proliferation of both primary MCL cultures (n = 7) and established cell lines (Granta 519 and SP-53) as shown by [(3)H]thymidine uptake and carboxyfluorescein diacetate succinimidyl ester labeling coupled with cyclin D1 staining.	Tretinoin	19-32	cyclin D1	Homo sapiens	282-291
15695403-2	2005	Here, we show that retinoic acid (RA) isomers significantly inhibit the proliferation of both primary MCL cultures (n = 7) and established cell lines (Granta 519 and SP-53) as shown by [(3)H]thymidine uptake and carboxyfluorescein diacetate succinimidyl ester labeling coupled with cyclin D1 staining.	Tretinoin	34-36	cyclin D1	Homo sapiens	282-291
15695403-5	2005	Most of RA-induced p27(Kip1) was bound to cyclin D1/cyclin-dependent kinase 4 complexes, probably contributing to the decreased cyclin-dependent kinase 4 kinase activity and pRb hypophosphorylation observed in RA-treated cells.	Tretinoin	8-10	cyclin D1	Homo sapiens	42-77
15695403-5	2005	Most of RA-induced p27(Kip1) was bound to cyclin D1/cyclin-dependent kinase 4 complexes, probably contributing to the decreased cyclin-dependent kinase 4 kinase activity and pRb hypophosphorylation observed in RA-treated cells.	Tretinoin	210-212	cyclin D1	Homo sapiens	42-77
15489884-5	2005	Decreased cyclin D1 expression was an early response to Id1 antisense oligonucleotide treatment.	Oligonucleotides	70-85	cyclin D1	Homo sapiens	10-19
16400524-8	2005	NAC treatment also restored cell cycle progression inhibited by rk-2 and down-regulated p53 and nuclear p21(Waf1/Cip1) expression induced by rk-2.These data suggest that rk-2 induces the BCE cell cycle arrest at G(0)-G(1) phase through inhibition of the cyclin D1/CDK4 complex caused by increase of ROS generation and nuclear cyclin-dependent kinase inhibitors.	Acetylcysteine	0-3	cyclin D1	Homo sapiens	254-263
15661398-8	2005	SAHA downregulated cyclin D1 and D2, and upregulated p53, p21, and p27.	Vorinostat	0-4	cyclin D1	Homo sapiens	19-35
16393119-6	2005	We concluded that the inhibitory effect of eupatilin on p21waf1/Cip1 expression is likely to be associated with the downregulation of cyclin D1 expression and AP-1 activation, which play an important role in the cell cycle arrest of ras-transformed breast epithelial cells.	eupatilin	43-52	cyclin D1	Homo sapiens	134-143
15920677-4	2005	Down-regulated expression of cyclin D1 explained the effect of clavulone II on G1 phase arrest of the cell cycle.	clavulone II	63-75	cyclin D1	Homo sapiens	29-38
15920677-7	2005	Taken together, it is suggested that low concentrations of clavulone II induce the antiproliferative effect through the down-regulation of cyclin D1 expression and G1 arrest of the cell cycle, while that of high concentration induce the apoptotic cell death via the modulation of members of caspases and Bcl-2 family proteins in HL-60 cells.	clavulone II	59-71	cyclin D1	Homo sapiens	139-148
15513923-1	2004	GSK-3beta-dependent phosphorylation of cyclin D1 at a conserved C-terminal residue, Thr-286, promotes CRM1-dependent cyclin D1 nuclear export.	Threonine	84-87	cyclin D1	Homo sapiens	39-48
16050133-0	2005	Activation of cyclin D1 by estradiol and spermine in MCF-7 breast cancer cells: a mechanism involving the p38 MAP kinase and phosphorylation of ATF-2.	Estradiol	27-36	cyclin D1	Homo sapiens	14-23
16050133-0	2005	Activation of cyclin D1 by estradiol and spermine in MCF-7 breast cancer cells: a mechanism involving the p38 MAP kinase and phosphorylation of ATF-2.	Spermine	41-49	cyclin D1	Homo sapiens	14-23
16050133-4	2005	DNA affinity immunoblot assays showed a six- to eightfold increase in the binding of ATF-2 to a 74-mer ATF/CRE oligonucleotide (ODN1) from cyclin D1 promoter in the presence of 4 nM E2 and 0.5 mM spermine, compared to untreated control.	Oligonucleotides	111-126	cyclin D1	Homo sapiens	139-148
16050133-4	2005	DNA affinity immunoblot assays showed a six- to eightfold increase in the binding of ATF-2 to a 74-mer ATF/CRE oligonucleotide (ODN1) from cyclin D1 promoter in the presence of 4 nM E2 and 0.5 mM spermine, compared to untreated control.	Spermine	196-204	cyclin D1	Homo sapiens	139-148
16050133-9	2005	Cyclin D1 promoter (-1745CD1) activity increased by approximately 12-fold (above control) in the presence of E2 and spermine, compared to a sixfold increase in the presence of E2 alone and a twofold increase with spermine.	Estradiol	109-111	cyclin D1	Homo sapiens	0-9
16050133-9	2005	Cyclin D1 promoter (-1745CD1) activity increased by approximately 12-fold (above control) in the presence of E2 and spermine, compared to a sixfold increase in the presence of E2 alone and a twofold increase with spermine.	Spermine	116-124	cyclin D1	Homo sapiens	0-9
16050133-9	2005	Cyclin D1 promoter (-1745CD1) activity increased by approximately 12-fold (above control) in the presence of E2 and spermine, compared to a sixfold increase in the presence of E2 alone and a twofold increase with spermine.	Estradiol	176-178	cyclin D1	Homo sapiens	0-9
16050133-9	2005	Cyclin D1 promoter (-1745CD1) activity increased by approximately 12-fold (above control) in the presence of E2 and spermine, compared to a sixfold increase in the presence of E2 alone and a twofold increase with spermine.	Spermine	213-221	cyclin D1	Homo sapiens	0-9
16050133-10	2005	Cells transfected with a dominant negative mutant of ATF-2 showed decreased transactivation of cyclin D1 promoter in response to E2 and spermine.	Estradiol	129-131	cyclin D1	Homo sapiens	95-104
16050133-10	2005	Cells transfected with a dominant negative mutant of ATF-2 showed decreased transactivation of cyclin D1 promoter in response to E2 and spermine.	Spermine	136-144	cyclin D1	Homo sapiens	95-104
16050133-11	2005	These results indicate that spermine can enhance E2-induced cell signaling and cyclin D1 transcription by activation of the p38 MAP kinase and phosphorylation of ATF-2, contributing to breast cancer cell proliferation.	Spermine	28-36	cyclin D1	Homo sapiens	79-88
15513923-1	2004	GSK-3beta-dependent phosphorylation of cyclin D1 at a conserved C-terminal residue, Thr-286, promotes CRM1-dependent cyclin D1 nuclear export.	Threonine	84-87	cyclin D1	Homo sapiens	117-126
15513923-2	2004	Herein, we have identified a short stretch of residues adjacent to Thr-286 that mediates CRM1 association and thus cyclin D1 nuclear export.	Threonine	67-70	cyclin D1	Homo sapiens	115-124
15601771-3	2004	Here, we observe that the antiviral guanosine analogue ribavirin binds to eIF4E with micromolar affinity at the functional site used by 7-methyl guanosine mRNA cap, competes with eIF4E:mRNA binding, and, at low micromolar concentrations, selectively disrupts eIF4E subcellular organization and transport and translation of mRNAs posttranscriptionally regulated by eIF4E, thereby reducing levels of oncogenes such as cyclin D1.	Ribavirin	55-64	cyclin D1	Homo sapiens	416-425
15604277-7	2004	Second, tetrandrine induces the proteasome-dependent degradation of CDK4, CDK6, cyclin D1, and E2F1.	tetrandrine	8-19	cyclin D1	Homo sapiens	80-89
15604292-9	2004	The R2-selective cAMP analog 8-Cl cAMP and R1A RNA silencing, stimulated cell proliferation and increased Cyclin D1 expression, respectively, in human and rat adenomatous somatotrophs.	Cyclic AMP	17-21	cyclin D1	Homo sapiens	106-115
15604292-9	2004	The R2-selective cAMP analog 8-Cl cAMP and R1A RNA silencing, stimulated cell proliferation and increased Cyclin D1 expression, respectively, in human and rat adenomatous somatotrophs.	8-cl	29-33	cyclin D1	Homo sapiens	106-115
15489888-1	2004	Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin have been shown to suppress transcription factor NF-kappaB, which controls the expression of genes such as cyclooxygenase (COX)-2 and cyclin D1, leading to inhibition of proliferation of tumor cells.	Aspirin	54-61	cyclin D1	Homo sapiens	196-205
15548426-4	2004	Treatment with the COX-2 specific inhibitor (NS 398 25 microM) and cyclin D1 inhibitor (flavopiridol 1 microM) increased neuronal survival and inhibited DNA fragmentation after anoxia.	alvocidib	88-100	cyclin D1	Homo sapiens	67-76
15548426-5	2004	NS-398 suppressed anoxia-induced expression of cyclin D1.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	cyclin D1	Homo sapiens	47-56
15548426-6	2004	Flavopiridol inhibited the anoxia-induced increased expression of cyclin D1, but had no effect on COX-2 expression.	alvocidib	0-12	cyclin D1	Homo sapiens	66-75
15548426-7	2004	Treatment with the selective COX-2 inhibitor, SC58125, had no affect on COX-2 expression but partially suppressed cyclin D1 expression in the cortex following middle cerebral artery occlusion in vivo.	1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole	46-53	cyclin D1	Homo sapiens	114-123
15585645-0	2004	Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines.	trichostatin A	30-44	cyclin D1	Homo sapiens	143-152
15585645-5	2004	Cyclin D1 degradation involved Skp2/p45, a regulatory component of the Skp1/Cullin/F-box complex; silencing SKP2 gene expression by RNA interference stabilized cyclin D1 and abrogated the cyclin D1 down-regulation response to TSA.	trichostatin A	226-229	cyclin D1	Homo sapiens	0-9
15585645-6	2004	CONCLUSIONS: Tamoxifen has been shown to inhibit ERalpha-mediated cyclin D1 transcription, and acquired resistance to tamoxifen is associated with a shift to ERalpha-independent cyclin D1 up-regulation.	Tamoxifen	13-22	cyclin D1	Homo sapiens	66-75
15585645-6	2004	CONCLUSIONS: Tamoxifen has been shown to inhibit ERalpha-mediated cyclin D1 transcription, and acquired resistance to tamoxifen is associated with a shift to ERalpha-independent cyclin D1 up-regulation.	Tamoxifen	118-127	cyclin D1	Homo sapiens	178-187
15585645-7	2004	Taken together, our data show that TSA effectively induces cyclin D1 down-regulation through both ERalpha-dependent and ERalpha-independent mechanisms, providing an important new strategy for combating resistance to antiestrogens.	trichostatin A	35-38	cyclin D1	Homo sapiens	59-68
15547725-8	2004	Treatment of HepG2 cells with MEK1/2 inhibitor U0126 resulted in cell cycle arrest, downregulation of cyclin D1 and Cdk-2 expression and inhibition of pRB phosphorylation at Ser780 and Ser795.	U 0126	47-52	cyclin D1	Homo sapiens	102-111
15585484-5	2004	We hypothesized that scintigraphic detection of CCND1 peptide nucleic acid (PNA) hybridization probes with a (99m)Tc-chelating peptide on the N terminus and an IGF1 peptide loop on the C terminus could detect CCND1 mRNA in human MCF7 breast cancer xenografts in nude mice from outside the body.	Technetium	114-116	cyclin D1	Homo sapiens	48-53
15585484-9	2004	RESULTS: IGF1R-overexpressing MCF7 cells internalized the fluorescein-chelator-CCND1 PNA-IGF1 peptide but not the mismatched control peptide.	Fluorescein	58-69	cyclin D1	Homo sapiens	79-84
15634644-5	2004	Flavopiridol/HA14-1-treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase, a modest activation of p38 mitogen-activated protein kinase, and down-regulation of cyclin D1.	alvocidib	0-12	cyclin D1	Homo sapiens	185-194
15601771-3	2004	Here, we observe that the antiviral guanosine analogue ribavirin binds to eIF4E with micromolar affinity at the functional site used by 7-methyl guanosine mRNA cap, competes with eIF4E:mRNA binding, and, at low micromolar concentrations, selectively disrupts eIF4E subcellular organization and transport and translation of mRNAs posttranscriptionally regulated by eIF4E, thereby reducing levels of oncogenes such as cyclin D1.	Guanosine	36-45	cyclin D1	Homo sapiens	416-425
15931363-6	2004	Retinoid-oral IEN studies (e.g., retinoid acid receptor-beta, p53, genetic instability, loss of heterozygosity, and cyclin D1) have advanced the overall understanding of the biology of intraepithelial carcinogenesis and preventive agent molecular mechanisms and targets, important advances for monitoring preventive interventions, assessing cancer risk, and pharmacogenomics.	Retinoids	0-8	cyclin D1	Homo sapiens	116-125
15810596-4	2004	Above 10 mg/L concentrations curcumin induced apoptosis [Apoptosis ratio &gt; or = (14.6 +/- 1.8)%, P &lt; 0.05] and down-regulated of the expression of NF-kappaB [Expression ratio &lt; or = (35.8 +/- 4.2)%, P &lt; 0.05], Cyclin D1 [Expression ratio &lt; or = (29.7 +/- 3.2)%, P &lt; 0.05].	Curcumin	29-37	cyclin D1	Homo sapiens	222-231
15457129-3	2004	We hypothesized that Cyclin D1 might be an important determinant of the sensitivity of neuroblastomas to cisplatin.	Cisplatin	105-114	cyclin D1	Homo sapiens	21-30
20368822-8	2004	EGCG differentially regulated the expression of genes and proteins (Bax, p21, Retinoblastoma, cyclin D1, CDK4 and Bcl-X(L)) more than 2 fold, showing a possible gene regulatory role for EGCG.	epigallocatechin gallate	0-4	cyclin D1	Homo sapiens	94-103
20368822-8	2004	EGCG differentially regulated the expression of genes and proteins (Bax, p21, Retinoblastoma, cyclin D1, CDK4 and Bcl-X(L)) more than 2 fold, showing a possible gene regulatory role for EGCG.	epigallocatechin gallate	186-190	cyclin D1	Homo sapiens	94-103
15475462-8	2004	OSI-461 enhanced the G0-G1 arrest caused by acyclic retinoid, and the combination of these agents caused a synergistic decrease in the levels of expression of cyclin D1 protein and mRNA, inhibited cyclin D1 promoter activity, decreased the level of hyperphosphorylated forms of the Rb protein, induced increased cellular levels of the p21(CIP1) protein and mRNA, and stimulated p21(CIP1) promoter activity.	(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride	0-7	cyclin D1	Homo sapiens	159-168
15475462-8	2004	OSI-461 enhanced the G0-G1 arrest caused by acyclic retinoid, and the combination of these agents caused a synergistic decrease in the levels of expression of cyclin D1 protein and mRNA, inhibited cyclin D1 promoter activity, decreased the level of hyperphosphorylated forms of the Rb protein, induced increased cellular levels of the p21(CIP1) protein and mRNA, and stimulated p21(CIP1) promoter activity.	(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride	0-7	cyclin D1	Homo sapiens	197-206
15235102-11	2004	BDRM35 also suppresses estradiol induction of endogenous target genes c-myc and cyclin D1 in MCF-7 breast cancer cells.	Estradiol	23-32	cyclin D1	Homo sapiens	80-89
15363954-5	2004	On the expression of cell cycle regulatory proteins, ferulic acid elevated the protein content of p21(waf1/cip1), decreased expression of cyclin D1 and inhibited phosphorylation of retinoblastoma protein, suggesting that ferulic acid inhibited VSMC proliferation by regulating the cell progression from G1 to S phase.	ferulic acid	53-65	cyclin D1	Homo sapiens	138-147
15313404-6	2004	Eupatilin inhibited the expression of cyclin D1, cyclin B1, Cdk2 and Cdc2 that are key regulators of the cell cycle.	eupatilin	0-9	cyclin D1	Homo sapiens	38-47
15313404-10	2004	Thus, the inhibitory effect of eupatilin on cyclin D1 expression appears to be mediated by targeting the Raf/MEK/ERK signaling cascades.	eupatilin	31-40	cyclin D1	Homo sapiens	44-53
15247282-0	2004	Proteasome-dependent degradation of cyclin D1 in 1-methyl-4-phenylpyridinium ion (MPP+)-induced cell cycle arrest.	1-Methyl-4-phenylpyridinium	49-76	cyclin D1	Homo sapiens	36-45
15247282-0	2004	Proteasome-dependent degradation of cyclin D1 in 1-methyl-4-phenylpyridinium ion (MPP+)-induced cell cycle arrest.	mangion-purified polysaccharide (Candida albicans)	82-86	cyclin D1	Homo sapiens	36-45
15247282-5	2004	The down-regulation of cyclin D1 protein was suppressed by a proteasome inhibitor, MG132.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	83-88	cyclin D1	Homo sapiens	23-32
15247282-8	2004	In addition, the pretreatment with nerve growth factor or lithium chloride, a glycogen synthase kinase-3beta inhibitor, suppressed the cyclin D1 down-regulation caused by MPP(+).	Lithium Chloride	58-74	cyclin D1	Homo sapiens	135-144
15517875-8	2004	Enhanced apoptosis by the co-treatment was abrogated by ectopic expression of cyclin D1, c-Myc or active MEK CONCLUSION: The combination of FK228 with STI571 is a promising treatment for Bcr-Abl-positive CML, but the activation of the MEK/ERK pathway and its downstream target genes may bring resistance to the co-treatment in leukemic cells.	romidepsin	140-145	cyclin D1	Homo sapiens	78-87
15517875-8	2004	Enhanced apoptosis by the co-treatment was abrogated by ectopic expression of cyclin D1, c-Myc or active MEK CONCLUSION: The combination of FK228 with STI571 is a promising treatment for Bcr-Abl-positive CML, but the activation of the MEK/ERK pathway and its downstream target genes may bring resistance to the co-treatment in leukemic cells.	Imatinib Mesylate	151-157	cyclin D1	Homo sapiens	78-87
15537345-1	2004	Using a high-throughput screening strategy, a series of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-ones was identified that inhibit the cyclin-dependent kinase (CDK) 4/cyclin D1 complex-mediated phosphorylation of a protein substrate with IC(50)s in the low micromolar range.	1-aryl-4,5-dihydro-1h	56-77	cyclin D1	Homo sapiens	174-183
15537345-1	2004	Using a high-throughput screening strategy, a series of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-ones was identified that inhibit the cyclin-dependent kinase (CDK) 4/cyclin D1 complex-mediated phosphorylation of a protein substrate with IC(50)s in the low micromolar range.	pyrazolo[3,4-d]pyrimidin-4-ones	78-109	cyclin D1	Homo sapiens	174-183
15569985-4	2004	The current study sought to determine whether the EGFR TKI erlotinib repressed cyclin D1 protein expression in immortalized HBE cells, lung cancer cell lines, and clinical aerodigestive tract cancers.	Erlotinib Hydrochloride	59-68	cyclin D1	Homo sapiens	79-88
15569985-11	2004	RESULTS: Erlotinib, at clinically achievable dosages, repressed BEAS-2B cell growth, triggered G1 arrest, and preferentially reduced cyclin D1 protein expression and transcriptional activation.	Erlotinib Hydrochloride	9-18	cyclin D1	Homo sapiens	133-142
15569985-12	2004	Erlotinib also preferentially repressed proliferation and cyclin D1 protein expression in responsive, but not resistant, non-small-cell lung cancer cell lines.	Erlotinib Hydrochloride	0-9	cyclin D1	Homo sapiens	58-67
15569985-19	2004	CONCLUSIONS: Taken together, these in vitro and in vivo findings provide direct evidence for repression of cyclin D1 protein as a surrogate marker of response in aerodigestive tract cancers to erlotinib treatment.	Erlotinib Hydrochloride	193-202	cyclin D1	Homo sapiens	107-116
15570011-0	2004	Deregulated cyclin D1 expression is associated with decreased efficacy of the selective epidermal growth factor receptor tyrosine kinase inhibitor gefitinib in head and neck squamous cell carcinoma cell lines.	Gefitinib	147-156	cyclin D1	Homo sapiens	12-21
15570011-3	2004	Therefore, we examined the relationship between deregulated cyclin D1 expression and sensitivity to gefitinib to determine whether this frequently occurring oncogenic change affected the cellular response to gefitinib.	Gefitinib	100-109	cyclin D1	Homo sapiens	60-69
15570011-7	2004	SCC 9 clones overexpressing cyclin D1 continued to proliferate and maintained their S-phase fraction when treated with gefitinib, whereas empty vector control clones and the parental SCC 9 cells were profoundly inhibited and displayed marked reductions in S-phase.	Gefitinib	119-128	cyclin D1	Homo sapiens	28-37
15570011-8	2004	The resistance of cyclin D1-overexpressing clones and cyclin D1-amplified cell lines was associated with maintenance of cyclin D1 expression after gefitinib treatment.	Gefitinib	147-156	cyclin D1	Homo sapiens	18-27
15570011-8	2004	The resistance of cyclin D1-overexpressing clones and cyclin D1-amplified cell lines was associated with maintenance of cyclin D1 expression after gefitinib treatment.	Gefitinib	147-156	cyclin D1	Homo sapiens	54-63
15570011-8	2004	The resistance of cyclin D1-overexpressing clones and cyclin D1-amplified cell lines was associated with maintenance of cyclin D1 expression after gefitinib treatment.	Gefitinib	147-156	cyclin D1	Homo sapiens	54-63
15355984-3	2004	This report demonstrates that Cdk2 in cyclin D1-Cdk2 complexes from mammary epithelial cells is phosphorylated on the activating phosphorylation site, Thr(160).	Threonine	151-154	cyclin D1	Homo sapiens	38-47
15355984-4	2004	Furthermore, cyclin D1-Cdk2 complexes catalyze Rb phosphorylation on multiple sites in vitro.	Rubidium	47-49	cyclin D1	Homo sapiens	13-22
15355984-6	2004	The cyclin D1-Cdk2 fusion protein expressed in epithelial cells was phosphorylated on Thr(160) and catalyzed the phosphorylation of Rb on multiple sites in vitro and in vivo.	Threonine	86-89	cyclin D1	Homo sapiens	4-13
15355984-6	2004	The cyclin D1-Cdk2 fusion protein expressed in epithelial cells was phosphorylated on Thr(160) and catalyzed the phosphorylation of Rb on multiple sites in vitro and in vivo.	Rubidium	132-134	cyclin D1	Homo sapiens	4-13
15355984-8	2004	Mutational inactivation of the cyclin D1 domain prevented activating phosphorylation of the Cdk2 domain on Thr(160).	Threonine	107-110	cyclin D1	Homo sapiens	31-40
15505422-4	2004	In cells exposed to rapamycin, we observed a dose-dependent downregulation of CCND1 (cyclin D1) and CDK4 gene expression and late G1 cell cycle arrest.	Sirolimus	20-29	cyclin D1	Homo sapiens	78-83
15505422-4	2004	In cells exposed to rapamycin, we observed a dose-dependent downregulation of CCND1 (cyclin D1) and CDK4 gene expression and late G1 cell cycle arrest.	Sirolimus	20-29	cyclin D1	Homo sapiens	85-94
15505422-7	2004	These results indicate that baseline Bcl-2 expression and therapy-induced downexpression of CCND1 and CDK4 may be regarded as molecular markers enabling the prediction and follow-up of the cellular effects on cell cycle and apoptosis induction of rapamycin in ovarian cancer.	Sirolimus	247-256	cyclin D1	Homo sapiens	92-97
15450939-8	2004	Both beta-ionone and geraniol inhibited CDK 2 activity and dose-dependently decreased the expression of cyclins D1, E, and A, and CDK 2 and 4, without changing the expression of p21cip1 or p27kip1.	beta-ionone	5-16	cyclin D1	Homo sapiens	104-117
15450939-8	2004	Both beta-ionone and geraniol inhibited CDK 2 activity and dose-dependently decreased the expression of cyclins D1, E, and A, and CDK 2 and 4, without changing the expression of p21cip1 or p27kip1.	geraniol	21-29	cyclin D1	Homo sapiens	104-117
15520223-14	2004	This implicated UBE1L in a retinoid chemoprevention mechanism involving cyclin D1 repression described previously.	Retinoids	27-35	cyclin D1	Homo sapiens	72-81
15277517-6	2004	We demonstrate that antizyme is capable of specific, noncovalent association with cyclin D1 and that this interaction accelerates cyclin D1 degradation in vitro in the presence of only antizyme, cyclin D1, purified 26 S proteasomes, and ATP.	Adenosine Triphosphate	237-240	cyclin D1	Homo sapiens	82-91
15277517-6	2004	We demonstrate that antizyme is capable of specific, noncovalent association with cyclin D1 and that this interaction accelerates cyclin D1 degradation in vitro in the presence of only antizyme, cyclin D1, purified 26 S proteasomes, and ATP.	Adenosine Triphosphate	237-240	cyclin D1	Homo sapiens	130-139
15277517-6	2004	We demonstrate that antizyme is capable of specific, noncovalent association with cyclin D1 and that this interaction accelerates cyclin D1 degradation in vitro in the presence of only antizyme, cyclin D1, purified 26 S proteasomes, and ATP.	Adenosine Triphosphate	237-240	cyclin D1	Homo sapiens	130-139
15277517-7	2004	In vivo, antizyme up-regulation induced either by the polyamine spermine or by antizyme overexpression causes reduction of intracellular cyclin D1 levels.	polyamine spermine	54-72	cyclin D1	Homo sapiens	137-146
15342193-5	2004	PGE2-mediated stabilization of beta-catenin was accompanied by T-cell factor/lymphoid enhancer factor (Tcf/Lef)-mediated transcriptional activation, which was followed by an increase in the cyclinD1 level.	Dinoprostone	0-4	cyclin D1	Homo sapiens	190-198
15350828-4	2004	The results showed that UA blocked cell cycle progression in the G1 phase that was associated with a marked decrease in the protein expression of cyclin D1, D2, and E and their activating partner cdk2, 4, and 6 with concomitant induction of p21/WAF1.	ursolic acid	24-26	cyclin D1	Homo sapiens	146-155
15297378-5	2004	We found that this stimulation of SMC proliferation requires Rho A/ROCK as inhibition with Y27632, a ROCK inhibitor, or dominant negative (DN) mutant Rho A blocks 5-HT-induced proliferation, cyclin D1 expression, phosphorylation of Elk, and the DNA binding of transcription factors, Egr-1 and GATA-4.	Y 27632	91-97	cyclin D1	Homo sapiens	191-200
15484403-0	2004	Overexpression of cyclin D1 correlates with sensitivity to cisplatin in squamous cell carcinoma cell lines of the head and neck.	Cisplatin	59-68	cyclin D1	Homo sapiens	18-27
15484403-3	2004	The objective of this study was to investigate cyclin D1 deregulation relative to sensitivity to cisplatin.	Cisplatin	97-106	cyclin D1	Homo sapiens	47-56
15484403-11	2004	Five of nine cell lines showing cyclin D1 amplification were highly sensitive to cisplatin (ID50 3-4.8 microM) and the remaining four revealed intermediate sensitivity.	Cisplatin	81-90	cyclin D1	Homo sapiens	32-41
15484403-12	2004	Five cell lines that strongly overexpressed cyclin D1 protein responded better to cisplatin than cell lines that showed any other expression (ID50 5.1 vs 11.2 microM; p=0.025; Student"s t-test).	Cisplatin	82-91	cyclin D1	Homo sapiens	44-53
15484403-13	2004	CONCLUSIONS: This in vitro study suggests that overexpression of cyclin D1 is associated with a good response to cisplatin in SCC cell lines.	Cisplatin	113-122	cyclin D1	Homo sapiens	65-74
15634644-5	2004	Flavopiridol/HA14-1-treated cells also exhibited a pronounced activation of Jun NH2-terminal kinase, a modest activation of p38 mitogen-activated protein kinase, and down-regulation of cyclin D1.	ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate	13-19	cyclin D1	Homo sapiens	185-194
15350370-9	2004	EGCG differentially regulated the expression of genes and proteins (Bax, p21, Retinoblastoma, cyclin D1, CDK4, Bcl-X(L)) more than 2-fold, showing a possible gene regulatory role of EGCG.	epigallocatechin gallate	0-4	cyclin D1	Homo sapiens	94-103
15117814-10	2004	Furthermore, the protein level of cyclin D1, a transcriptional target of NF-kappaB, was reduced significantly in BITC-treated BxPC-3 cells.	benzyl isothiocyanate	113-117	cyclin D1	Homo sapiens	34-43
15131010-10	2004	The relative expression of pS2, progesterone receptor and cyclin D1 was increased in animals consuming the Novasoy(R), mixed isoflavones and genistin.	Isoflavones	125-136	cyclin D1	Homo sapiens	58-67
15131010-10	2004	The relative expression of pS2, progesterone receptor and cyclin D1 was increased in animals consuming the Novasoy(R), mixed isoflavones and genistin.	genistin	141-149	cyclin D1	Homo sapiens	58-67
15350370-9	2004	EGCG differentially regulated the expression of genes and proteins (Bax, p21, Retinoblastoma, cyclin D1, CDK4, Bcl-X(L)) more than 2-fold, showing a possible gene regulatory role of EGCG.	epigallocatechin gallate	182-186	cyclin D1	Homo sapiens	94-103
15544931-0	2004	Cyclin D1 expression is dependent on estrogen receptor function in tamoxifen-resistant breast cancer cells.	Tamoxifen	67-76	cyclin D1	Homo sapiens	0-9
15544931-4	2004	In tamoxifen-sensitive breast cancer cells, tamoxifen inhibits, whereas estrogen induces, expression of cyclin D1, a key cell cycle regulatory protein.	Tamoxifen	3-12	cyclin D1	Homo sapiens	104-113
15544931-4	2004	In tamoxifen-sensitive breast cancer cells, tamoxifen inhibits, whereas estrogen induces, expression of cyclin D1, a key cell cycle regulatory protein.	Tamoxifen	44-53	cyclin D1	Homo sapiens	104-113
15544931-6	2004	Thus, to determine whether cyclin D1 is involved in the growth of tamoxifen-resistant cells, we developed several tamoxifen-resistant variants from MCF-7 cells.	Tamoxifen	66-75	cyclin D1	Homo sapiens	27-36
15544931-8	2004	We show here that cyclin D1 expression is maintained at comparable levels in all tamoxifen-resistant variants, whereas pS2, another estrogen-regulated protein, is not.	Tamoxifen	81-90	cyclin D1	Homo sapiens	18-27
15544931-11	2004	Thus, changes in cyclin D1 expression upon second-line hormonal therapy may predict hormonal sensitivity of tamoxifen-resistant tumors.	Tamoxifen	108-117	cyclin D1	Homo sapiens	17-26
15544931-12	2004	These studies suggest that estrogen receptor mediates cyclin D1 expression and growth of tamoxifen-resistant tumors.	Tamoxifen	89-98	cyclin D1	Homo sapiens	54-63
15548374-6	2004	In mechanistic studies, IP6 resulted in an increase in cyclin-dependent kinase inhibitors (CDKIs) Cip1/p21 and Kip1/p27 levels, together with a decrease in cyclin-dependent kinase (CDK) 4 and cyclin D1 protein levels.	Phytic Acid	24-27	cyclin D1	Homo sapiens	192-201
15322241-4	2004	p21(WAF1/CIP1), which is involved in the assembly of cyclin D1/cyclin-dependent kinase-4 complexes, was increased by DHT or TCDD when each compound was administered singly but was reduced to background levels in cells simultaneously treated with DHT and TCDD.	Dihydrotestosterone	117-120	cyclin D1	Homo sapiens	53-88
15322241-4	2004	p21(WAF1/CIP1), which is involved in the assembly of cyclin D1/cyclin-dependent kinase-4 complexes, was increased by DHT or TCDD when each compound was administered singly but was reduced to background levels in cells simultaneously treated with DHT and TCDD.	Polychlorinated Dibenzodioxins	124-128	cyclin D1	Homo sapiens	53-88
15322241-4	2004	p21(WAF1/CIP1), which is involved in the assembly of cyclin D1/cyclin-dependent kinase-4 complexes, was increased by DHT or TCDD when each compound was administered singly but was reduced to background levels in cells simultaneously treated with DHT and TCDD.	Polychlorinated Dibenzodioxins	254-258	cyclin D1	Homo sapiens	53-88
15246556-4	2004	Further investigation revealed that hypsiziprenol A9 decreased expression of phosphorylated retinoblastoma protein (ppRb), cyclin D1, and cyclin E in a dose-dependent manner.	hypsiziprenol A9	36-52	cyclin D1	Homo sapiens	123-132
15497704-3	2004	RESULTS: Gemcitabine above 10(-8) mol/L enhanced the growth suppression [suppression ratio &gt; or = (50.8 +/- 4.2)%, P &lt; 0.05] and apoptosis [apoptosis ratio &gt; or = (22.9 +/- 2.3)%, P &lt; 0.05] and down-regulation of the expression of cyclin D1 [expression ratio &lt; or = (9.6 +/- 1.6)%, P &lt; 0.01] induced by paclitaxel above 10(-7) mol/L in PC-3 cells.	gemcitabine	9-20	cyclin D1	Homo sapiens	243-252
15190077-2	2004	Our earlier studies have shown that troglitazone (TZD)-mediated activation of PPARgamma2 in hepatocytes inhibits growth and attenuates cyclin D1 transcription via modulating CREB levels.	Troglitazone	36-48	cyclin D1	Homo sapiens	135-144
15190077-2	2004	Our earlier studies have shown that troglitazone (TZD)-mediated activation of PPARgamma2 in hepatocytes inhibits growth and attenuates cyclin D1 transcription via modulating CREB levels.	tzd	50-53	cyclin D1	Homo sapiens	135-144
15289334-5	2004	We demonstrate here that in EJ human bladder cancer cells containing a tetracycline-regulatable s-HB-EGF or pro-HB-EGF expression system, s-HB-EGF expression increased their transformed phenotypes, including growth rate, colony-forming ability, and activation of cyclin D1 promoter, as well as induction of vascular endothelial growth factor in vitro.	Tetracycline	71-83	cyclin D1	Homo sapiens	263-272
15028555-11	2004	The mTOR inhibitor rapamycin had similar inhibitory effects on G(1) cell cycle progression and on the expression of cyclin D1, CDK4, CDC25A, and retinoblastoma phosphorylation.	Sirolimus	19-28	cyclin D1	Homo sapiens	116-125
15282324-2	2004	Appropriate CCND1 gene activity is essential for normal development and physiology of the mammary gland, where it is regulated by ovarian steroids through a mechanism(s) that is not fully elucidated.	Steroids	138-146	cyclin D1	Homo sapiens	12-17
15277494-6	2004	An antisense oligonucleotide was used to inhibit cyclin D1 expression.	Oligonucleotides	13-28	cyclin D1	Homo sapiens	49-58
15156159-11	2004	Additionally, the methylator suppressed growth of Hep3B cells dose dependently, accompanied by cyclin D1 downregulation, and the growth suppression was abrogated by potent COX-2 inhibition with a COX-2 selective inhibitor celecoxib, but these responses were not found in HuH7 cells.	Celecoxib	222-231	cyclin D1	Homo sapiens	95-104
15282324-3	2004	We report here that CCND1 promoter activation by estrogens in human breast cancer cells is mediated by recruitment of a c-Jun/c-Fos/estrogen receptor alpha complex to the tetradecanoyl phorbol acetate-responsive element of the gene, together with Oct-1 to a site immediately adjacent.	Tetradecanoylphorbol Acetate	171-200	cyclin D1	Homo sapiens	20-25
15256475-0	2004	Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9.	Celecoxib	33-42	cyclin D1	Homo sapiens	239-248
15256475-2	2004	CS-associated malignancies including cancers of the larynx, oral cavity, and pharynx, esophagus, pancreas, kidney, bladder, and lung; all are known to overexpress the nuclear factor-kappaB (NF-kappaB)-regulated gene products cyclin D1, cyclooxygenase (COX)-2, and matrix metalloprotease-9.	Cesium	0-2	cyclin D1	Homo sapiens	225-234
15212949-3	2004	Decreasing phospho-ERK with the pharmacological inhibitors, PD98059 and U0126, markedly suppresses hyperoxia-stimulated phospho-p53(Ser15), p53, and p21(CIP1), and also restores the hyperoxia-reduced kinase activities of cyclin D1/E1-Cdks.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	60-67	cyclin D1	Homo sapiens	221-230
15212949-3	2004	Decreasing phospho-ERK with the pharmacological inhibitors, PD98059 and U0126, markedly suppresses hyperoxia-stimulated phospho-p53(Ser15), p53, and p21(CIP1), and also restores the hyperoxia-reduced kinase activities of cyclin D1/E1-Cdks.	U 0126	72-77	cyclin D1	Homo sapiens	221-230
15188006-5	2004	All the NSAIDs, except rofecoxib, decreased nuclear beta-catenin content and cyclin D1 protein levels in parallel with their antiproliferative activity.	rofecoxib	23-32	cyclin D1	Homo sapiens	77-86
15104433-0	2004	Synthetic approaches to indolo[6,7-a]pyrrolo[3,4-c]carbazoles: potent cyclin D1/CDK4 inhibitors.	indolo[6,7-a]pyrrolo[3,4-c]carbazoles	24-61	cyclin D1	Homo sapiens	70-79
15120940-0	2004	Ectopic cyclin D1 expression blocks STI571-induced erythroid differentiation of K562 cells.	Imatinib Mesylate	36-42	cyclin D1	Homo sapiens	8-17
15138474-5	2004	A combination of histological grade plus immunochemical staining for BCL-2, p27 and Cyclin D1, generated a useful prognostic index for tamoxifen-treated patients but not for those treated by surgery alone.	Tamoxifen	135-144	cyclin D1	Homo sapiens	84-93
15138475-0	2004	Cyclin D1 overexpression is a negative predictive factor for tamoxifen response in postmenopausal breast cancer patients.	Tamoxifen	61-70	cyclin D1	Homo sapiens	0-9
15138475-4	2004	Interestingly in the 55 strongly ERalpha positive samples with moderate or low cyclin D1 levels, patients responded to tamoxifen treatment whereas the 46 patients with highly ERalpha positive and cyclin D1 overexpressing tumours did not show any difference in survival between tamoxifen and no treatment.	Tamoxifen	119-128	cyclin D1	Homo sapiens	79-88
15138475-7	2004	Our results suggest that cyclin D1 overexpression predicts for tamoxifen treatment resistance in breast cancer, which is line with recent experimental data using breast cancer cell lines and overexpression systems.	Tamoxifen	63-72	cyclin D1	Homo sapiens	25-34
15094364-4	2004	STI571 abrogates PDGF-BB-dependent cyclin D1 and cyclin A protein expression and inhibits transcriptional activation of reporter genes driven by the human cyclin A gene promoter.	Imatinib Mesylate	0-6	cyclin D1	Homo sapiens	35-44
15004225-6	2004	Our results show that low concentrations of DCA (5 and 50 microM) significantly increase tyrosine phosphorylation of beta-catenin, induce urokinase-type plasminogen activator, uPAR, and cyclin D1 expression and enhance colon cancer cell proliferation and invasiveness.	Deoxycholic Acid	44-47	cyclin D1	Homo sapiens	186-195
15116100-6	2004	Mutational analysis indicated that this effect was mediated through the cyclic AMP response element (CRE) (predominantly) and the TCF sites in the cyclin D1 promoter, which was also inhibited by dnCREB.	Cyclic AMP	72-82	cyclin D1	Homo sapiens	147-156
15116100-8	2004	Chromatin immunoprecipitation studies revealed a G-17-mediated increase in the interaction of beta-catenin with cyclin D1 CRE, which was attenuated by dnTCF4 and dnCREB.	dntcf4	151-157	cyclin D1	Homo sapiens	112-121
15116100-8	2004	Chromatin immunoprecipitation studies revealed a G-17-mediated increase in the interaction of beta-catenin with cyclin D1 CRE, which was attenuated by dnTCF4 and dnCREB.	dncreb	162-168	cyclin D1	Homo sapiens	112-121
15517885-3	2004	The growth-inhibitory effects of resveratrol are mediated through cell-cycle arrest; upregulation of p21Cip1/WAF1, p53 and Bax; down-regulation of survivin, cyclin D1, cyclin E, Bcl-2, Bcl-xL and clAPs; and activation of caspases.	Resveratrol	33-44	cyclin D1	Homo sapiens	157-166
15132987-6	2004	Furthermore, 6-OHDA decreased the expression of cyclin D1, a substrate of GSK3beta, and dephosphorylated Akt, the upstream signaling component of GSK3beta.	Oxidopamine	13-19	cyclin D1	Homo sapiens	48-57
15060836-7	2004	A positive relationship of cyclin D1 with p27/kip1 in both UC and CD was detected.	Cadmium	66-68	cyclin D1	Homo sapiens	27-36
15355641-9	2004	CONCLUSION: EGCG inhibits AP-1, JNK, c-Jun and cyclinD1 which are key targets on AP-1 signal transduction pathway.	epigallocatechin gallate	12-16	cyclin D1	Homo sapiens	47-55
15205322-9	2004	Repression of cyclin D1 by p16(INK4a) occurred independently of the p16(INK4a)-cdk4-binding function and required a cAMP-response element/activating transcription factor-2-binding site.	Cyclic AMP	116-120	cyclin D1	Homo sapiens	14-23
15178330-0	2004	Estrogen receptor activation at serine 305 is sufficient to upregulate cyclin D1 in breast cancer cells.	Serine	32-38	cyclin D1	Homo sapiens	71-80
15172998-2	2004	Here, we establish that KLF6 mediates growth inhibition through an interaction with cyclin D1, leading to reduced phosphorylation of the retinoblastoma protein (Rb) at Ser(795).	Serine	168-171	cyclin D1	Homo sapiens	84-93
15173009-9	2004	Stable overexpression of PKG Ibeta was associated with decreased cellular levels of beta-catenin and cyclin D1 and increased levels of p21(CIP1).	ibeta	29-34	cyclin D1	Homo sapiens	101-110
15173009-12	2004	Taken together, these results indicate that activation of PKG Ibeta is sufficient to inhibit growth and cell migration and induce apoptosis in human colon cancer cells and that these effects are associated with inhibition of the transcription of cyclin D1 and an increase in the expression of p21(CIP1).	ibeta	62-67	cyclin D1	Homo sapiens	246-255
15193259-1	2004	R-etodolac, a nonsteroidal anti-inflammatory drug, inhibits the progression of CWRSA6 androgen-independent and LuCaP-35 androgen-dependent prostate cancer xenograft growth through downregulation of cyclin D1 expression via the PPARgamma pathway.	Etodolac	0-10	cyclin D1	Homo sapiens	198-207
15239399-5	2004	Results of immunohistochemical analysis of paraffin-embedded specimens were positive for cyclin D1 and Bcl2 in the tumor cells.	Paraffin	43-51	cyclin D1	Homo sapiens	89-98
15179185-5	2004	Furthermore, TSA treatment led to reduction in cyclin D1 whereas cyclin D3 accumulated, the latter due to increased protein stability.	trichostatin A	13-16	cyclin D1	Homo sapiens	47-56
15111320-6	2004	The Ishikawa cell line, with stable or tetracycline-regulated expression of mutant beta-catenin, showed an increase in expression levels of cyclin D1, p14ARF, p53, and p21WAF1 but not PML, and activation of beta-catenin-TCF4-mediated transcription determined with TOP/FOP constructs.	Tetracycline	39-51	cyclin D1	Homo sapiens	140-149
15126379-8	2004	Furthermore, caffeine inhibited the activation of the cyclin D1-cdk4 complex in a dose-dependent manner.	Caffeine	13-21	cyclin D1	Homo sapiens	54-63
15225829-6	2004	In established hyperparathyroidism, characterized by highly enhanced-TGFalpha/EGFR co-expression, vitamin D therapy arrests growth by suppressing EGFR-growth signals from the plasma membrane and nuclear EGFR actions as a transactivator of the cyclin D1 gene, an important contributor to parathyroid hyperplasia in humans.	Vitamin D	98-107	cyclin D1	Homo sapiens	243-252
15004225-8	2004	Inhibition of beta-catenin with small interfering RNA significantly reduced DCA-induced uPAR and cyclin D1 expression.	Deoxycholic Acid	76-79	cyclin D1	Homo sapiens	97-106
15116089-5	2004	PD173074-mediated inhibition of FGFR activity caused downregulation of cyclin D1 and cyclin D2 expression, inhibition of cyclin D/cdk4 activity and, as a consequence, reduction of pRB phosphorylation.	PD 173074	0-8	cyclin D1	Homo sapiens	71-80
15116089-6	2004	Retroviral-mediated ectopic expression of cyclin D1 prevented pRB hypophosphorylation and the cell cycle G1 block in PD173074-treated cells, suggesting a central role for D cyclins in proliferation of FGFR-driven breast cancer cells.	PD 173074	117-125	cyclin D1	Homo sapiens	42-51
15104433-1	2004	Synthesis of indolo[6,7-a]pyrrolo[3,4-c]carbazoles 1, a new class of cyclin D1/CDK4 inhibitors, by oxidation of the corresponding aryl indolylmaleimides 2, will be described.	indolo[6,7-a]pyrrolo[3,4-c]carbazoles	13-50	cyclin D1	Homo sapiens	69-78
15104433-1	2004	Synthesis of indolo[6,7-a]pyrrolo[3,4-c]carbazoles 1, a new class of cyclin D1/CDK4 inhibitors, by oxidation of the corresponding aryl indolylmaleimides 2, will be described.	aryl indolylmaleimides	130-152	cyclin D1	Homo sapiens	69-78
15010259-9	2004	Pretreatment with PD98059 significantly inhibited elastase-induced cyclin D1 activity.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	18-25	cyclin D1	Homo sapiens	67-76
14754892-4	2004	At the KN-93 arrest point, we found that cyclin D1/cdk4 complexes had assembled with p21/p27, accumulated in the nucleus, and become phosphorylated on Thr-172, yet were relatively inactive.	Threonine	151-154	cyclin D1	Homo sapiens	41-50
14754892-6	2004	KN-93 prevented both the activation of cdk4, and this shift in cyclin D1 migration and overexpression of cyclin D1/cdk4 overcame the KN-93 arrest.	KN 93	0-5	cyclin D1	Homo sapiens	63-72
14754892-6	2004	KN-93 prevented both the activation of cdk4, and this shift in cyclin D1 migration and overexpression of cyclin D1/cdk4 overcame the KN-93 arrest.	KN 93	0-5	cyclin D1	Homo sapiens	105-114
15123247-5	2004	This knowledge was applied to the design of compounds in the otherwise CDK2-selective 2-anilino-4-(thiazol-5-yl)pyrimidine pharmacophore that are potent and highly selective ATP antagonists of CDK4/cyclin D1.	2-anilino-4-(thiazol-5-yl)pyrimidine	86-122	cyclin D1	Homo sapiens	198-207
15073138-8	2004	Transfection experiments in BEAS-2B cells indicated that RA treatment repressed expression of wild-type cyclin D1 and cyclin E, but ALLN inhibited this degradation.	Tretinoin	57-59	cyclin D1	Homo sapiens	104-113
15123247-5	2004	This knowledge was applied to the design of compounds in the otherwise CDK2-selective 2-anilino-4-(thiazol-5-yl)pyrimidine pharmacophore that are potent and highly selective ATP antagonists of CDK4/cyclin D1.	Adenosine Triphosphate	174-177	cyclin D1	Homo sapiens	198-207
15001399-4	2004	Cyclin D1 expression and cell-cycle progression followed the metal-induced Akt phosphorylation.	Metals	61-66	cyclin D1	Homo sapiens	0-9
14767060-5	2004	Because cyclin D1 mRNA was induced normally in the cyclosporin A-treated cells, we analyzed the half-life of cyclin D1 in the presence of cyclosporin A and found no difference from control cells.	Cyclosporine	51-64	cyclin D1	Homo sapiens	109-118
14767060-6	2004	However, cyclosporin A treatment dramatically reduced cyclin D1 protein synthesis.	Cyclosporine	9-22	cyclin D1	Homo sapiens	54-63
15026545-6	2004	C-substituted diindolylmethanes inhibit carcinogen-induced rat mammary tumor growth, induce differentiation in 3T3-L1 preadipocytes, inhibit MCF-7 cell growth and G(0)/G(1)-S phase progression, induce apoptosis, and down-regulate cyclin D1 protein and estrogen receptor alpha in breast cancer cells.	3,3'-diindolylmethane	14-31	cyclin D1	Homo sapiens	230-239
15041706-9	2004	Treatment of lung carcinoma cells with the PPARgamma ligands PGJ2, ciglitazone, troglizaone, and GW1929 elevated p21 mRNA and protein levels and reduced cyclin D1 mRNA levels.	ciglitazone	67-78	cyclin D1	Homo sapiens	153-162
15041706-9	2004	Treatment of lung carcinoma cells with the PPARgamma ligands PGJ2, ciglitazone, troglizaone, and GW1929 elevated p21 mRNA and protein levels and reduced cyclin D1 mRNA levels.	troglizaone	80-91	cyclin D1	Homo sapiens	153-162
14871472-2	2004	In this study, the effect of the two main tocopherols, namely, alpha-tocopherol and gamma-tocopherol, and their corresponding metabolites (alpha- and gamma-carboxyethyl hydroxychromans) was studied on proliferation and cyclin D1 expression of the prostate cancer cell line PC-3.	gamma-Tocopherol	84-100	cyclin D1	Homo sapiens	219-228
14871472-8	2004	Tocopherols and carboxyethyl hydroxychromans exerted an inhibitory effect on cyclin D1 expression parallel to the retardation of cell growth.	Tocopherols	0-11	cyclin D1	Homo sapiens	77-86
14871472-8	2004	Tocopherols and carboxyethyl hydroxychromans exerted an inhibitory effect on cyclin D1 expression parallel to the retardation of cell growth.	carboxyethyl-hydroxychroman	16-44	cyclin D1	Homo sapiens	77-86
14871472-10	2004	Furthermore, the inhibition of cyclin D1 expression by gamma-carboxyethyl hydroxychroman was competed for by alpha-carboxyethyl hydroxychroman.	gamma-carboxyethyl hydroxychroman	55-88	cyclin D1	Homo sapiens	31-40
14871472-10	2004	Furthermore, the inhibition of cyclin D1 expression by gamma-carboxyethyl hydroxychroman was competed for by alpha-carboxyethyl hydroxychroman.	alpha-carboxyethyl hydroxychroman	109-142	cyclin D1	Homo sapiens	31-40
14604889-3	2004	We studied downstream events following c-MYC and CYCLIN D1 gene inhibition, by lipoplex-delivered MYC and CYCLIN D1 antisense oligodeoxy nucleotides (aODNM, aODND1), in in vitro cultured human HepG2 and rat Morris 5123 hepatoma cells.	Oligodeoxyribonucleotides	126-148	cyclin D1	Homo sapiens	106-115
14718259-8	2004	The bFGF-mediated increase in cyclin D1 protein levels after 8 h was reduced in the presence of 15d-PGJ2, but not RG.	15-deoxy-delta(12,14)-prostaglandin J2	96-104	cyclin D1	Homo sapiens	30-39
15059376-3	2004	When ciglitazone was added, the proliferation was observed by growth curve and the differentiation of cells was observed by flow cytometry, and the expression of cyclinD1 was observed by Western blot.	ciglitazone	5-16	cyclin D1	Homo sapiens	162-170
14741686-7	2004	Genes involved in cell cycle regulation (CCND1 and CDKN1A) were down-regulated consistent with our finding that phenytoin per se did not have cell proliferation activity.	Phenytoin	112-121	cyclin D1	Homo sapiens	41-46
14767992-7	2004	ATPgammaS treatment alone and in combination with epidermal growth factor (EGF) substantially increased cyclin D1 and proliferating cell nuclear antigen (PCNA) protein expression and hepatocyte proliferation in vitro.	adenosine 5'-O-(3-thiotriphosphate)	0-9	cyclin D1	Homo sapiens	104-113
14871980-14	2004	Furthermore, changes in cyclin D1 levels provide a potential pharmacodynamic marker of response to rapamycin.	Sirolimus	99-108	cyclin D1	Homo sapiens	24-33
14767992-8	2004	Extracellular ATP as low as 10 nM was sufficient to potentiate EGF-induced cyclin D1 expression.	Adenosine Triphosphate	14-17	cyclin D1	Homo sapiens	75-84
15127614-0	2004	[Effects of 9-cis-retinoic acid on cell cycle and expression of cyclin D1 and cdk4 in lung cancer cells].	Alitretinoin	12-31	cyclin D1	Homo sapiens	64-73
14603522-8	2004	Kaempferol treatment also led in a dose-dependent decrease in the expression of progesterone receptor (PgR), cyclin D1, and insulin receptor substrate 1 (IRS-1).	kaempferol	0-10	cyclin D1	Homo sapiens	109-118
15127614-1	2004	AIM: To study the effects of 9-cis-retinoic acid (9-cis-RA) on cell cycle and expression of cyclin D1 and cdk4 in lung cancer cells.	Alitretinoin	29-48	cyclin D1	Homo sapiens	92-101
15127614-1	2004	AIM: To study the effects of 9-cis-retinoic acid (9-cis-RA) on cell cycle and expression of cyclin D1 and cdk4 in lung cancer cells.	Alitretinoin	50-58	cyclin D1	Homo sapiens	92-101
14729633-0	2004	The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway.	Roscovitine	38-44	cyclin D1	Homo sapiens	125-134
14729633-0	2004	The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway.	Roscovitine	46-59	cyclin D1	Homo sapiens	125-134
15566959-11	2004	However, anti-apoptotic Bcl-2 and Bcl-X(L) were elevated and the cell cycle regulator cyclin D1 was slightly upregulated with both 1 and 5 microM cisplatin treatment.	Cisplatin	146-155	cyclin D1	Homo sapiens	86-95
14710233-9	2004	As a result, the protein levels of the positively regulated TCF targets Met and cyclin D1 were downregulated after sulindac treatment.	Sulindac	115-123	cyclin D1	Homo sapiens	80-89
14720377-1	2004	BACKGROUND &amp; OBJECTIVE: Overexpression of cyclin D1 was shown in many tumors.	Adenosine Monophosphate	12-15	cyclin D1	Homo sapiens	46-55
14757441-5	2004	Furthermore, when HL-60 myeloid leukemic cells were differentiated with phorbol ester (TPA), PBK/TOPK protein expression was strongly down-regulated by 24 h. Under these same conditions, phosphorylated c-Myc was rapidly down-regulated (by 4 h), while the levels of cyclin D1 and phosphorylated p38 were constant.	Phorbol Esters	72-85	cyclin D1	Homo sapiens	265-274
14757441-5	2004	Furthermore, when HL-60 myeloid leukemic cells were differentiated with phorbol ester (TPA), PBK/TOPK protein expression was strongly down-regulated by 24 h. Under these same conditions, phosphorylated c-Myc was rapidly down-regulated (by 4 h), while the levels of cyclin D1 and phosphorylated p38 were constant.	Tetradecanoylphorbol Acetate	87-90	cyclin D1	Homo sapiens	265-274
14744730-8	2004	ORs did not vary with cyclin D1 status in relation to alcohol, body size, or cigarette smoking, with the following exception; for noncardia gastric adenocarcinomas the cyclin D1- tumors showed a 2-fold elevation in the OR with ever smoking.	Alcohols	54-61	cyclin D1	Homo sapiens	168-177
15672866-4	2004	Inostamycin inhibited activation of mitogen-activated kinases (ERK and p38) and elevation of cyclin D1 induced by VEGF.	inostamycin	0-11	cyclin D1	Homo sapiens	93-102
15672866-5	2004	These data suggest that inostamycin reduced both proliferation and migration of HUVECs by targeting ERK-cyclin D1 and p38, respectively.	inostamycin	24-35	cyclin D1	Homo sapiens	104-113
15579072-8	2004	A recent study has shown that 7-hydroxycoumarin inhibits the release of Cyclin D1, which is overexpressed in many types of cancer.	7-hydroxycoumarin	30-47	cyclin D1	Homo sapiens	72-81
14654956-7	2004	SFN induced signals that inhibited the activity of cyclin-dependent kinase cdk4 with an up-stream induction of cdk inhibitor p21WAF-1/Cip-1, and reduced cyclin D1.	sulforaphane	0-3	cyclin D1	Homo sapiens	153-162
15587392-7	2004	ATRA inhibited the mRNA expression of CDK6, CDK4, cyclinD3 and cyclinD1.	Tretinoin	0-4	cyclin D1	Homo sapiens	63-71
15587392-8	2004	Sodium butyrate inhibited the mRNA expression of CDK2, cyclinD2 and cyclinD1.	Butyric Acid	0-15	cyclin D1	Homo sapiens	68-76
15587392-9	2004	ATRA and sodium butyrate inhibited the mRNA expression of CDK6, CDK4, CDK2, cyclinD1, cyclinD2 and cyclinD3.	Tretinoin	0-4	cyclin D1	Homo sapiens	76-84
15587392-9	2004	ATRA and sodium butyrate inhibited the mRNA expression of CDK6, CDK4, CDK2, cyclinD1, cyclinD2 and cyclinD3.	Butyric Acid	9-24	cyclin D1	Homo sapiens	76-84
15641681-8	2004	It was indicated that retinoic acid could increase beta-catenin level of the whole cell protein and decrease nuclear beta-catenin, downregulating beta-cat/TCF signaling activity and reducing target gene cyclinD1 protein level.	Tretinoin	22-35	cyclin D1	Homo sapiens	203-211
15034217-4	2004	Expression of cyclin D1 and p53 was analyzed using standard immunohistochemical method of B5-fixed and routinely processed paraffin-embedded bone marrow specimens.	Paraffin	123-131	cyclin D1	Homo sapiens	14-23
14657069-2	2003	A common adenine-to-guanine substitution polymorphism (A870G) in the CCND1 gene results in an altered messenger RNA transcript and a longer-life protein, which are preferentially encoded by the A allele.	Adenine	9-16	cyclin D1	Homo sapiens	69-74
14657069-2	2003	A common adenine-to-guanine substitution polymorphism (A870G) in the CCND1 gene results in an altered messenger RNA transcript and a longer-life protein, which are preferentially encoded by the A allele.	Guanine	20-27	cyclin D1	Homo sapiens	69-74
12816758-7	2003	Transient ERK activation and subsequent cyclin D1 induction were observed on adding 10 microM ZnCl2 in MSSM in the presence of cell proliferation.	zinc chloride	94-99	cyclin D1	Homo sapiens	40-49
12816758-8	2003	On the other hand, prolonged ERK activity was observed with a subsequent increase of cyclin D1 and p21(Cip/WAF1) on adding 100 microM ZnCl2 in MSSM, and this was associated with nonproliferation.	zinc chloride	134-139	cyclin D1	Homo sapiens	85-94
14751834-8	2003	Peptide nucleic acid (PNA) dodecamers antisense to CCND1 and MYC mRNAs were then extended from the N-terminus of IGF1, followed by a chelator peptide, using Fmoc coupling for all residues.	Peptide Nucleic Acids	22-25	cyclin D1	Homo sapiens	51-56
14609739-5	2003	DHAc also showed significant effects on the gene expression of the house-keeping genes GAP-DH and beta-actin, as well as on NF-ATc, p65, I-kappa B alpha, bcl-2, and cyclin D1.	DHAC	0-4	cyclin D1	Homo sapiens	165-174
12970168-5	2003	Furthermore, this study also demonstrated that MEK inhibitor PD98059 that inhibits the phosphorylation of p42/44 MAPK also caused reduction of cyclin D1 level and inhibition of cell proliferation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	61-68	cyclin D1	Homo sapiens	143-152
15320491-7	2003	2-DG also increased the levels of cyclin D1 at 24 hr in BMG-1 cell line.	Deoxyglucose	0-4	cyclin D1	Homo sapiens	34-43
14713576-5	2003	The retinoic acid-sensitive cell line HTB35 was transfected for inducible CRABP I overexpression to test the role of this protein in modulating the sensitivity to retinoic acid and radiation as well as in regulating RAR-beta 2 and cyclin D1 expression.	Tretinoin	4-17	cyclin D1	Homo sapiens	231-240
12921950-6	2003	Surprisingly, cyclin D1 expression was upregulated after induction by TPA, TNFalpha with IFNgamma or BA.	Tetradecanoylphorbol Acetate	70-73	cyclin D1	Homo sapiens	14-23
12921950-9	2003	Quantitative RT-PCR showed as much as a 288-fold increase of cyclin D1 specific mRNA after a 24h induction by TPA.	Tetradecanoylphorbol Acetate	110-113	cyclin D1	Homo sapiens	61-70
14647467-6	2003	In differentiated progenitor cells, nuclear localization of ectopic cyclin D1 induced apoptosis, and the DNA-damaging compound camptothecin caused nuclear accumulation of endogenous cyclin D1, accompanied by Rb phosphorylation.	Camptothecin	127-139	cyclin D1	Homo sapiens	182-191
14642781-3	2003	6-Nitro-7-hydroxycoumarin was shown to alter cell cycle progression, leading to the appearance of a sub-G(1) peak, containing hypodiploid DNA, accompanied by increases in both poly(ADP-ribose)polymerase cleavage and decreased expression of cyclin D1.	6-nitro-7-hydroxycoumarin	0-25	cyclin D1	Homo sapiens	240-249
14552791-0	2003	Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors.	aryl[a]pyrrolo[3,4-c]carbazoles	0-31	cyclin D1	Homo sapiens	45-54
14614451-4	2003	In mechanistic studies related its effect on cell cycle progression, silibinin treatment resulted in an upregulation of Kip1/p27 and Cip1/p21 protein as well as mRNA levels, and decreased CDK2, CDK4, cyclin E and cyclin D1 protein levels together with an inhibition in CDK2 and CDK4 kinase activities.	Silybin	69-78	cyclin D1	Homo sapiens	213-222
14552791-2	2003	These new series of aryl[a]pyrrolo[3,4-c]carbazoles were evaluated as inhibitors of Cyclin D1-CDK4.	aryl[a]pyrrolo[3,4-c]carbazoles	20-51	cyclin D1	Homo sapiens	84-93
14587026-1	2003	All-trans retinoic acid (ATRA) can down regulate the anti-apoptotic protein Bcl-2 and the cell cycle proteins cyclin D1 and cdk2 in estrogen receptor-positive breast cancer cells.	Tretinoin	0-23	cyclin D1	Homo sapiens	110-119
14580692-4	2003	A JAK-specific inhibitor, tyrphostin AG490, markedly inhibited Stat3 activation and expression of cyclin D1, bcl-xL and vascular endothelial growth factor mRNAs estimated by RT-PCR, as followed by growth arrest (6.3-21.3% vs controls; P&lt;0.001) of pancreatic cancer cells.	Tyrphostins	26-36	cyclin D1	Homo sapiens	98-107
14981992-5	2003	Four (31%) out of 13 patients with CCND1 amplification responded to NAC whereas the response rate in the non-amplified group was 79% (p = 0.011).	nac	68-71	cyclin D1	Homo sapiens	35-40
14981992-8	2003	CONCLUSION: Detection of CCND1 amplification using FISH may be a useful marker of sensitivity to NAC and chemoradiotherapy for HNSCC.	nac	97-100	cyclin D1	Homo sapiens	25-30
14612495-1	2003	Glycogen synthase kinase-3beta-dependent phosphorylation of cyclin D1 at a conserved COOH-terminal residue, Thr-286, promotes CRM1-dependent cyclin D1 nuclear export at the G(1)-S boundary.	Carbonic Acid	85-89	cyclin D1	Homo sapiens	60-69
14612495-1	2003	Glycogen synthase kinase-3beta-dependent phosphorylation of cyclin D1 at a conserved COOH-terminal residue, Thr-286, promotes CRM1-dependent cyclin D1 nuclear export at the G(1)-S boundary.	Carbonic Acid	85-89	cyclin D1	Homo sapiens	141-150
14612495-1	2003	Glycogen synthase kinase-3beta-dependent phosphorylation of cyclin D1 at a conserved COOH-terminal residue, Thr-286, promotes CRM1-dependent cyclin D1 nuclear export at the G(1)-S boundary.	Threonine	108-111	cyclin D1	Homo sapiens	60-69
14612495-1	2003	Glycogen synthase kinase-3beta-dependent phosphorylation of cyclin D1 at a conserved COOH-terminal residue, Thr-286, promotes CRM1-dependent cyclin D1 nuclear export at the G(1)-S boundary.	Threonine	108-111	cyclin D1	Homo sapiens	141-150
14612495-2	2003	Mutations that perturb the phosphorylation of cyclin D1 at Thr-286 contribute to cell transformation, although to date, no such mutations have been found in human cancers.	Threonine	59-62	cyclin D1	Homo sapiens	46-55
14612495-3	2003	Cyclin D1 (CCND1) undergoes alternative splicing leading to the production of an mRNA predicted to encode a unique cyclin D1 isoform, cyclin D1b, which lacks Thr-286.	Threonine	158-161	cyclin D1	Homo sapiens	0-9
14612495-3	2003	Cyclin D1 (CCND1) undergoes alternative splicing leading to the production of an mRNA predicted to encode a unique cyclin D1 isoform, cyclin D1b, which lacks Thr-286.	Threonine	158-161	cyclin D1	Homo sapiens	11-16
14587026-1	2003	All-trans retinoic acid (ATRA) can down regulate the anti-apoptotic protein Bcl-2 and the cell cycle proteins cyclin D1 and cdk2 in estrogen receptor-positive breast cancer cells.	Tretinoin	25-29	cyclin D1	Homo sapiens	110-119
14587026-4	2003	In both cell lines ATRA and 9-cis RA induced the most profound decreases in cyclin D1 and cdk2 expression and also mediated the largest growth inhibition.	Radium	21-23	cyclin D1	Homo sapiens	76-85
14559232-8	2003	The mTOR inhibitor rapamycin has similar inhibitory effects on G(1) cell cycle progression and expression of cyclin D1, CDK4, and Rb phosphorylation.	Sirolimus	19-28	cyclin D1	Homo sapiens	109-118
14608044-5	2003	To elucidate whether lycopene modulates cyclins involved in cell cycle progression, protein expressions of cyclins D1 and E were analyzed.	Lycopene	21-29	cyclin D1	Homo sapiens	107-123
14576498-13	2003	The expression of several cell cycle (p21, p27, cyclin D1) and apoptotic (survivin, Bcl-xL) regulatory proteins was altered after U0126 and/or sulindac treatment.	U 0126	130-135	cyclin D1	Homo sapiens	48-57
14576498-13	2003	The expression of several cell cycle (p21, p27, cyclin D1) and apoptotic (survivin, Bcl-xL) regulatory proteins was altered after U0126 and/or sulindac treatment.	Sulindac	143-151	cyclin D1	Homo sapiens	48-57
14566053-8	2003	NO-ASA reduced the expression of cyclin D1, a downstream target gene that plays an important role in colon carcinogenesis.	nitroxy-butyl-acetylsalicylic acid	0-6	cyclin D1	Homo sapiens	33-42
14568412-1	2003	N-(2-Hydroxypropyl)methacrylamide (HPMA) copolymer carrier containing the anticancer drug doxorubicin and targeted with B1 monoclonal antibody (mAb) to BCL1 leukemia cells was synthesised and tested in vitro and in vivo.	N-(2-hydroxypropyl)methacrylamide	0-33	cyclin D1	Homo sapiens	152-156
14568412-1	2003	N-(2-Hydroxypropyl)methacrylamide (HPMA) copolymer carrier containing the anticancer drug doxorubicin and targeted with B1 monoclonal antibody (mAb) to BCL1 leukemia cells was synthesised and tested in vitro and in vivo.	N-(2-hydroxypropyl)methacrylamide	35-39	cyclin D1	Homo sapiens	152-156
14568412-1	2003	N-(2-Hydroxypropyl)methacrylamide (HPMA) copolymer carrier containing the anticancer drug doxorubicin and targeted with B1 monoclonal antibody (mAb) to BCL1 leukemia cells was synthesised and tested in vitro and in vivo.	copolymer	41-50	cyclin D1	Homo sapiens	152-156
14646596-4	2003	Association constant, Km for ATP in CDK4/cyclin D1 was found as 418 microM, a value unusually high whereas CDK2/cyclin A was 23 microM, a value close to most of other regulatory protein kinases.	Adenosine Triphosphate	29-32	cyclin D1	Homo sapiens	41-50
14646596-8	2003	These data suggest cellular CDK4/cyclin D1 activity is tightly associated with cellular ATP concentration.	Adenosine Triphosphate	88-91	cyclin D1	Homo sapiens	33-42
14646596-9	2003	Also, analysis of phosphorylated serine/threonine sites on RB catalyzed by CDK4/cyclin D1 and CDK2/cyclin A showed significant differences in their preference of phosphorylation sites in RB C-terminal domain.	Serine	33-39	cyclin D1	Homo sapiens	80-89
14646596-9	2003	Also, analysis of phosphorylated serine/threonine sites on RB catalyzed by CDK4/cyclin D1 and CDK2/cyclin A showed significant differences in their preference of phosphorylation sites in RB C-terminal domain.	Threonine	40-49	cyclin D1	Homo sapiens	80-89
14572665-5	2003	DNA synthesis and cyclin D1 expression were suppressed in hepatocytes grown on the glycopolymer as compared with those grown on fibronectin and collagen.	glycopolymer	83-95	cyclin D1	Homo sapiens	18-27
14550307-5	2003	In contrast, the compound exhibited non-competitive inhibition with respect to ATP toward cdk4/cyclin D1, with a 45-fold reduced potency.	Adenosine Triphosphate	79-82	cyclin D1	Homo sapiens	95-104
12896906-5	2003	Serum treatment increased the pErbB3/p85 complexes and also stimulated phosphorylation of Akt and GSK3beta, increase in cyclin D1 and cell cycle progression, and these events were blocked by the Akt activation inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	220-228	cyclin D1	Homo sapiens	120-129
14642081-7	2003	CONCLUSION: CyclinD1, p16, E2F-1 and Rb played the important roles from MP into SP and then DCIS.	sp	80-82	cyclin D1	Homo sapiens	12-20
14579783-0	2003	Antiproliferative action of neomycin is associated with inhibition of cyclin D1 activation in glioma cells.	Neomycin	28-36	cyclin D1	Homo sapiens	70-79
14611687-13	2003	The result of a Northern blot showed that RBBP1 were inhibited after an induction of IPTG for 36 h. Another Northern blot analysis proved that mRNA levels of cyclin D1 and c-myc increased in proportion to K-ras expression.	Isopropyl Thiogalactoside	85-89	cyclin D1	Homo sapiens	158-167
14579783-4	2003	Here, we employed mitotic selection to synchronize the C6 glioma cell cycle at the start of the G1 phase and assessed the effects of neomycin on cyclin D1 protein detection by immunocytochemical analysis.	Neomycin	133-141	cyclin D1	Homo sapiens	145-154
14579783-5	2003	Cyclin D1 activation as well as cell proliferation were already significantly reduced after 3 h of incubation of the cells with neomycin.	Neomycin	128-136	cyclin D1	Homo sapiens	0-9
14579783-6	2003	These findings suggested that the antiproliferative effects of neomycin in gliomas could be mediated by inhibition of the expression of cyclin D1 gene and support further consideration of therapeutic use of neomycin in a Phase I clinical study for patients with recurrent glioblastoma.	Neomycin	63-71	cyclin D1	Homo sapiens	136-145
14579783-6	2003	These findings suggested that the antiproliferative effects of neomycin in gliomas could be mediated by inhibition of the expression of cyclin D1 gene and support further consideration of therapeutic use of neomycin in a Phase I clinical study for patients with recurrent glioblastoma.	Neomycin	207-215	cyclin D1	Homo sapiens	136-145
14522919-10	2003	Cyclin D1 and p21(Waf1/CIP1) were additionally confirmed as important mediators of CDDO growth inhibition in genetically modified breast cancer cell lines.	2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid	83-87	cyclin D1	Homo sapiens	0-9
12888923-7	2003	Cyclin D1 expression and basal phosphorylation of c-Raf, MAPK, Elk-1 and Akt-1 in PC-3 cells was also inhibited by quercetin treatment.	Quercetin	115-124	cyclin D1	Homo sapiens	0-9
12972956-3	2003	Furthermore, the change of retinoblastoma protein regulation mediated by CCND1 may play a role in the development of methotrexate (MTX) resistance via an associated higher activity of enzymes that are inhibited by MTX.	Methotrexate	117-129	cyclin D1	Homo sapiens	73-78
12972956-3	2003	Furthermore, the change of retinoblastoma protein regulation mediated by CCND1 may play a role in the development of methotrexate (MTX) resistance via an associated higher activity of enzymes that are inhibited by MTX.	Methotrexate	131-134	cyclin D1	Homo sapiens	73-78
12972956-3	2003	Furthermore, the change of retinoblastoma protein regulation mediated by CCND1 may play a role in the development of methotrexate (MTX) resistance via an associated higher activity of enzymes that are inhibited by MTX.	Methotrexate	214-217	cyclin D1	Homo sapiens	73-78
12796485-8	2003	Moreover, Rb phosphorylation, which lies immediately downstream of the cyclin D1-Cdk4-p21WAF1/Cip1 complex, was blocked either by Sp1 overexpression or antisense p21WAF1/Cip1.	Rubidium	10-12	cyclin D1	Homo sapiens	71-80
12907607-0	2003	Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1.	ursolic acid	0-12	cyclin D1	Homo sapiens	240-249
12810706-4	2003	Furthermore, mutation of this lysine relieves the repression of the cyclin D1 promoter by C/EBP beta-1 without altering the subnuclear localization of C/EBP beta-1.	Lysine	30-36	cyclin D1	Homo sapiens	68-77
12869389-8	2003	Pretreatment with the phosphatidylinositol 3"-kinase (PI 3"-kinase) inhibitor wortmannin suppressed BTC-induced cyclin D1 mRNA and protein and DNA synthesis activity.	Wortmannin	78-88	cyclin D1	Homo sapiens	112-121
12869389-11	2003	Pretreatment with PD98059 suppressed AR-induced cyclin D1 mRNA and protein.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	18-25	cyclin D1	Homo sapiens	48-57
12941814-12	2003	In addition, activation of a common tumor-derived AR allele by 17 beta-estradiol and progesterone was inhibited through ectopic expression of cyclin D1.	Estradiol	63-80	cyclin D1	Homo sapiens	142-151
12941814-12	2003	In addition, activation of a common tumor-derived AR allele by 17 beta-estradiol and progesterone was inhibited through ectopic expression of cyclin D1.	Progesterone	85-97	cyclin D1	Homo sapiens	142-151
12904179-12	2003	Moreover, E(2) and raloxifene significantly inhibited the PDGF-induced cyclin D1 promoter activity in A10 cells transfected with cDNA for ERalpha but not in the parental cells.	Estradiol	10-14	cyclin D1	Homo sapiens	71-80
12909331-6	2003	Western blot analysis shows that delphinidin reverses the vascular endothelial growth factor-induced decrease in expression of cyclin-dependent kinase inhibitor p27(kip1) and the vascular endothelial growth factor-induced increase of cyclin D1 and cyclin A, both being necessary to achieve the G(1)-to-S transition.	delphinidin	33-44	cyclin D1	Homo sapiens	234-243
12904179-12	2003	Moreover, E(2) and raloxifene significantly inhibited the PDGF-induced cyclin D1 promoter activity in A10 cells transfected with cDNA for ERalpha but not in the parental cells.	Raloxifene Hydrochloride	19-29	cyclin D1	Homo sapiens	71-80
12867074-8	2003	Certain retinoids, natural and synthetic derivatives of vitamin A, repress cyclin D1, but activation of the epidermal growth factor receptor (EGFR) induces cyclin D1.	Retinoids	8-17	cyclin D1	Homo sapiens	75-84
12867074-8	2003	Certain retinoids, natural and synthetic derivatives of vitamin A, repress cyclin D1, but activation of the epidermal growth factor receptor (EGFR) induces cyclin D1.	Vitamin A	56-65	cyclin D1	Homo sapiens	75-84
12867074-9	2003	Retinoids and specific chemopreventive agents can activate the proteasome-dependent degradation of cyclin D1 and also repress EGFR expression, thereby reducing cyclin D1 levels.	Retinoids	0-9	cyclin D1	Homo sapiens	99-108
12867074-9	2003	Retinoids and specific chemopreventive agents can activate the proteasome-dependent degradation of cyclin D1 and also repress EGFR expression, thereby reducing cyclin D1 levels.	Retinoids	0-9	cyclin D1	Homo sapiens	160-169
12883267-8	2003	Arsenic increased expression of the P21 protein and decreased levels of cyclin A, cyclin B1 and cyclin D1, but expression of CDK2, CDK4, CDK6, and cyclin E were not affected.	Arsenic	0-7	cyclin D1	Homo sapiens	96-105
14514379-0	2003	[Detection of cyclin D1 protein expression and t(11;14) chromosomal translocation in paraffin-embedded tissues and its clinicopathologic significance for mantle cell lymphoma].	Paraffin	85-93	cyclin D1	Homo sapiens	14-23
14514379-1	2003	OBJECTIVE: To investigate the feasibility of detecting cyclin D1 protein expression and t(11;14) chromosomal translocation in paraffin-embedded tissues and its diagnostic and differential diagnostic significance for mantle cell lymphoma (MCL).	Paraffin	126-134	cyclin D1	Homo sapiens	55-64
14514379-12	2003	CONCLUSION: The combined detection of cyclin D1 and t(11;14) in paraffin-embedded tissues is found to be a specific and feasible method for diagnosis and differential diagnosis of mantle cell lymphoma.	Paraffin	64-72	cyclin D1	Homo sapiens	38-47
12824014-0	2003	Novel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7-a]pyrrolo[3,4-c]carbazoles.	indolo[6,7-a]pyrrolo[3,4-c]carbazoles	55-92	cyclin D1	Homo sapiens	28-37
12807725-0	2003	Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1.	Curcumin	0-8	cyclin D1	Homo sapiens	212-221
12836159-4	2003	Retinoic acid caused an increase in nuclear beta-catenin levels in SH-SY5Y cells, which was followed by an increase in cyclin D1 protein levels.	Tretinoin	0-13	cyclin D1	Homo sapiens	119-128
12807725-0	2003	Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1.	Curcumin	10-27	cyclin D1	Homo sapiens	212-221
12807725-10	2003	The inhibition of NF-kappaB activation correlated with suppression of CS-induced NF-kappaB-dependent cyclin D1, cyclooxygenase-2 and matrix metalloproteinase-9 expression.	Cesium	70-72	cyclin D1	Homo sapiens	101-110
12759338-9	2003	The JNK inhibitor SP600125 antagonized R- and S-flurbiprofen-induced AP-1 DNA binding, suppression of cyclin D1 expression, and the G1-cell cycle block.	pyrazolanthrone	18-26	cyclin D1	Homo sapiens	102-111
12759338-9	2003	The JNK inhibitor SP600125 antagonized R- and S-flurbiprofen-induced AP-1 DNA binding, suppression of cyclin D1 expression, and the G1-cell cycle block.	Flurbiprofen	48-60	cyclin D1	Homo sapiens	102-111
12864941-6	2003	Rapamycin and its analogues also prevent cyclin-dependent kinase (CDK) activation, inhibit retinoblastoma protein phosphorylation, and accelerate the turnover of cyclin D1, leading to a deficiency of active CDK4/cyclin D1 complexes, all of which potentially contribute to the prominent inhibitory effects of rapamycin at the G1/S boundary of the cell cycle.	Sirolimus	0-9	cyclin D1	Homo sapiens	162-171
12816986-7	2003	PS-341or BAY 11-induced G(1) cell cycle arrest was associated with the inhibition of cyclin D1 expression, a molecular genetic marker of MCL.	ps-341or bay 11	0-15	cyclin D1	Homo sapiens	85-94
12720008-10	2003	The alpha5 integrin, keratinocyte growth factor receptor and cyclin D1 mRNA levels were higher compared to the controls as early as 2 h after ethanol and 30 min after acetone treatment of the cells.	Ethanol	142-149	cyclin D1	Homo sapiens	61-70
12720008-10	2003	The alpha5 integrin, keratinocyte growth factor receptor and cyclin D1 mRNA levels were higher compared to the controls as early as 2 h after ethanol and 30 min after acetone treatment of the cells.	Acetone	167-174	cyclin D1	Homo sapiens	61-70
12864941-6	2003	Rapamycin and its analogues also prevent cyclin-dependent kinase (CDK) activation, inhibit retinoblastoma protein phosphorylation, and accelerate the turnover of cyclin D1, leading to a deficiency of active CDK4/cyclin D1 complexes, all of which potentially contribute to the prominent inhibitory effects of rapamycin at the G1/S boundary of the cell cycle.	Sirolimus	0-9	cyclin D1	Homo sapiens	212-221
12759391-4	2003	Cyclin D1 promoter activity was measured in LPA-treated OVCAR-3 cells cotransfected with cyclin D1 promoter-driven luciferase constructs and cDNA expression plasmids for IkappaBalphaM (a nuclear factor kappaB [NFkappaB] super-repressor).	lysophosphatidic acid	44-47	cyclin D1	Homo sapiens	0-9
12649303-7	2003	Clofibrate (50 microM), ciprofibrate (50 microM), and 15d-PGJ2 (2.5 microM) inhibited c-myb and cyclin D2 expression, whereas they did not affect c-myc and cyclin D1 expression.	Clofibrate	0-10	cyclin D1	Homo sapiens	156-165
12649303-7	2003	Clofibrate (50 microM), ciprofibrate (50 microM), and 15d-PGJ2 (2.5 microM) inhibited c-myb and cyclin D2 expression, whereas they did not affect c-myc and cyclin D1 expression.	15-deoxyprostaglandin J2	54-62	cyclin D1	Homo sapiens	156-165
12955881-5	2003	In fetal cells, however, the induction of apoptosis and differentiation by RA was obtained via inhibition of cyclin D1-cdk4 activity, as result of an increased binding to the p16 inhibitor.	Tretinoin	75-77	cyclin D1	Homo sapiens	109-118
12747775-0	2003	Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors.	indolocarbazoles	70-86	cyclin D1	Homo sapiens	97-106
12759391-6	2003	LPA treatment increased cyclin D1 protein in a dose- and time-dependent manner in OVCAR-3 cells but not in IOSE-29 cells.	lysophosphatidic acid	0-3	cyclin D1	Homo sapiens	24-33
12759391-7	2003	LPA stimulated cyclin D1 promoter activity (3.0-fold, 95% confidence interval [CI] = 2.7-fold to 3.3-fold).	lysophosphatidic acid	0-3	cyclin D1	Homo sapiens	15-24
12738746-0	2003	Cyclin d1 overexpression sensitizes breast cancer cells to fenretinide.	Fenretinide	59-70	cyclin D1	Homo sapiens	0-9
12778079-8	2003	For the analysis of phosphatidylinositol-3 kinase (PI3-K) dependence of protein kinases and cell cycle transition, the PI3-K inhibitors LY294002 and wortmannin were used showing decreased kinase activities, antiproliferative and radiation-dependent G2 accumulation-abrogating effects accompanied by downregulation of cyclin D1 and phospho-pRb in cells attached to polystyrene.	Wortmannin	149-159	cyclin D1	Homo sapiens	317-326
12707028-8	2003	In addition, the mRNA levels of cyclin D1 and Stat 3 were determined by quantitative real-time reverse transcriptase-polymerase chain reaction of paraffin-embedded microdissected tissue.	Paraffin	146-154	cyclin D1	Homo sapiens	32-41
12894581-8	2003	IB-MECA treatment also induced down-modulation of the expression of NF-kappa B/p65, known to regulate the transcription of cyclin D1 and c-Myc.	N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine	0-7	cyclin D1	Homo sapiens	123-132
12738746-1	2003	PURPOSE: Fenretinide has shown promise in the chemoprevention of breast cancer, a tumor type in which the oncogene cyclin D1 is overexpressed frequently.	Fenretinide	9-20	cyclin D1	Homo sapiens	115-124
12738746-2	2003	We aimed at determining the effect of cyclin D1 level on the response to fenretinide treatment.	Fenretinide	73-84	cyclin D1	Homo sapiens	38-47
12738746-4	2003	RESULTS: We show here that cells overexpressing cyclin D1 are significantly more sensitive to fenretinide than genetically matched cells that express low levels of cyclin D1, and that fenretinide prevents tumor formation arising from cyclin D1-overexpressing cells.	Fenretinide	94-105	cyclin D1	Homo sapiens	48-57
12738746-4	2003	RESULTS: We show here that cells overexpressing cyclin D1 are significantly more sensitive to fenretinide than genetically matched cells that express low levels of cyclin D1, and that fenretinide prevents tumor formation arising from cyclin D1-overexpressing cells.	Fenretinide	184-195	cyclin D1	Homo sapiens	48-57
12738746-4	2003	RESULTS: We show here that cells overexpressing cyclin D1 are significantly more sensitive to fenretinide than genetically matched cells that express low levels of cyclin D1, and that fenretinide prevents tumor formation arising from cyclin D1-overexpressing cells.	Fenretinide	184-195	cyclin D1	Homo sapiens	164-173
12738746-4	2003	RESULTS: We show here that cells overexpressing cyclin D1 are significantly more sensitive to fenretinide than genetically matched cells that express low levels of cyclin D1, and that fenretinide prevents tumor formation arising from cyclin D1-overexpressing cells.	Fenretinide	184-195	cyclin D1	Homo sapiens	164-173
12738746-5	2003	Furthermore, we show that fenretinide is also able to promote the regression of cyclin D1-positive tumors.	Fenretinide	26-37	cyclin D1	Homo sapiens	80-89
12738746-6	2003	We also show that cells expressing a mutant of cyclin D1 that cannot bind to cdk4 are also more sensitive to fenretinide.	Fenretinide	109-120	cyclin D1	Homo sapiens	47-56
12738746-7	2003	CONCLUSIONS: These results suggest that fenretinide may be particularly useful in the treatment of cyclin D1-positive breast cancers, and that the interaction between cyclin D1 and fenretinide is independent of cyclin D1 binding to cdk4.	Fenretinide	40-51	cyclin D1	Homo sapiens	99-108
12762808-3	2003	Sulfates 3 and 6 inhibit CDK4/cyclin D1 complexation, whereas 1 and 4 do not.	Sulfates	0-8	cyclin D1	Homo sapiens	30-39
12684681-4	2003	When we examined the effects of this drug on ACHN cells, trichostatin decreased the levels of CDK4, CDK6, cyclin D1 and cyclin A proteins.	trichostatin A	57-69	cyclin D1	Homo sapiens	106-115
12480939-1	2003	MCF-7 and ZR-75 breast cancer cells infected with an adenovirus constitutively expressing high levels of cyclin D1 demonstrated widespread mitochondrial translocation of Bax and cytochrome c release that was approximately doubled after the addition of all-trans retinoic acid (RA) or Bcl-2 antisense oligonucleotide.	Tretinoin	262-275	cyclin D1	Homo sapiens	105-114
12710892-0	2003	A low toxicity maintenance regime, using eicosapentaenoic acid and readily available drugs, for mantle cell lymphoma and other malignancies with excess cyclin D1 levels.	Eicosapentaenoic Acid	41-62	cyclin D1	Homo sapiens	152-161
12710892-7	2003	Agents which have recently been shown to block cyclin D1 translation by regulating calcium levels are the unsaturated essential fatty acid, eicosapentaenoic acid (EPA), the antidiabetic thiazolidinediones, and the antifungal agent, clotrimazole.	Calcium	83-90	cyclin D1	Homo sapiens	47-56
12710892-7	2003	Agents which have recently been shown to block cyclin D1 translation by regulating calcium levels are the unsaturated essential fatty acid, eicosapentaenoic acid (EPA), the antidiabetic thiazolidinediones, and the antifungal agent, clotrimazole.	unsaturated essential fatty acid	106-138	cyclin D1	Homo sapiens	47-56
12710892-7	2003	Agents which have recently been shown to block cyclin D1 translation by regulating calcium levels are the unsaturated essential fatty acid, eicosapentaenoic acid (EPA), the antidiabetic thiazolidinediones, and the antifungal agent, clotrimazole.	Eicosapentaenoic Acid	140-161	cyclin D1	Homo sapiens	47-56
12710892-7	2003	Agents which have recently been shown to block cyclin D1 translation by regulating calcium levels are the unsaturated essential fatty acid, eicosapentaenoic acid (EPA), the antidiabetic thiazolidinediones, and the antifungal agent, clotrimazole.	Eicosapentaenoic Acid	163-166	cyclin D1	Homo sapiens	47-56
12710892-7	2003	Agents which have recently been shown to block cyclin D1 translation by regulating calcium levels are the unsaturated essential fatty acid, eicosapentaenoic acid (EPA), the antidiabetic thiazolidinediones, and the antifungal agent, clotrimazole.	Thiazolidinediones	186-204	cyclin D1	Homo sapiens	47-56
12710892-7	2003	Agents which have recently been shown to block cyclin D1 translation by regulating calcium levels are the unsaturated essential fatty acid, eicosapentaenoic acid (EPA), the antidiabetic thiazolidinediones, and the antifungal agent, clotrimazole.	Clotrimazole	232-244	cyclin D1	Homo sapiens	47-56
12480939-1	2003	MCF-7 and ZR-75 breast cancer cells infected with an adenovirus constitutively expressing high levels of cyclin D1 demonstrated widespread mitochondrial translocation of Bax and cytochrome c release that was approximately doubled after the addition of all-trans retinoic acid (RA) or Bcl-2 antisense oligonucleotide.	Oligonucleotides	300-315	cyclin D1	Homo sapiens	105-114
12480939-6	2003	Both RA and antisense Bcl-2 oligonucleotide decreased Bcl-2 protein levels and markedly increased caspase activity and apoptosis in cyclin D1-infected cells.	Oligonucleotides	28-43	cyclin D1	Homo sapiens	132-141
12657252-0	2003	Synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin D1/CDK4 inhibitors.	quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles	13-66	cyclin D1	Homo sapiens	70-79
12629224-2	2003	Here, we report that Pitx2, in response to the Wntbeta-catenin pathway and growth signals, also can regulate c-Myc and cyclin D1.	wntbeta-catenin	47-62	cyclin D1	Homo sapiens	119-128
12586744-4	2003	CYP 2C9 overexpression was associated with the activation of Akt and an increase in cyclin D1 expression, effects that were abolished by the epidermal growth factor (EGF) receptor inhibitor, AG1478, which also prevented the CYP 2C9-induced increase in cell proliferation.	RTKI cpd	191-197	cyclin D1	Homo sapiens	84-93
12540838-3	2003	We found that CREB activity, including its DNA binding ability and phosphorylation on residue Ser-133, was strongly inhibited by Cpd 5, followed by suppression of CRE-mediated transcription of cyclin D1 and Bcl-2 genes.	Serine	94-97	cyclin D1	Homo sapiens	193-202
12654183-4	2003	METHODS: SP immunohistochemistry was used to detect expression of p-MAPK, p-Stat3, and cyclin D1 protein in 45 cases of HL of various types.	TFF2 protein, human	9-11	cyclin D1	Homo sapiens	87-96
12522140-5	2003	The decrease in cyclin D1 protein seemed to be caused by accelerated proteolysis, since it was abrogated by N-acetyl-Leu-Leu-norleucinal, a proteasome inhibitor.	n-acetyl-leu-leu	108-124	cyclin D1	Homo sapiens	16-25
12522140-6	2003	DIF-3-induced degradation of cyclin D1 was also prevented by treatment with lithium chloride, an inhibitor of glycogen synthase kinase-3beta (GSK-3beta), suggesting that DIF-3 induced cyclin D1 proteolysis through the activation of GSK-3beta.	Lithium Chloride	76-92	cyclin D1	Homo sapiens	29-38
12522140-6	2003	DIF-3-induced degradation of cyclin D1 was also prevented by treatment with lithium chloride, an inhibitor of glycogen synthase kinase-3beta (GSK-3beta), suggesting that DIF-3 induced cyclin D1 proteolysis through the activation of GSK-3beta.	Lithium Chloride	76-92	cyclin D1	Homo sapiens	184-193
12615709-1	2003	Treatment of MCF-7 cells with the peroxisome proliferator-activated receptor (PPAR) gamma agonists ciglitazone or 15-deoxy-Delta 12,14-prostaglandin J2 resulted in a concentration- and time-dependent decrease of cyclin D1 and estrogen receptor (ER) alpha proteins, and this was accompanied by decreased cell proliferation and G(1)-G(0)--&gt;S-phase progression.	ciglitazone	99-110	cyclin D1	Homo sapiens	212-221
12615709-1	2003	Treatment of MCF-7 cells with the peroxisome proliferator-activated receptor (PPAR) gamma agonists ciglitazone or 15-deoxy-Delta 12,14-prostaglandin J2 resulted in a concentration- and time-dependent decrease of cyclin D1 and estrogen receptor (ER) alpha proteins, and this was accompanied by decreased cell proliferation and G(1)-G(0)--&gt;S-phase progression.	15-deoxy-delta	114-128	cyclin D1	Homo sapiens	212-221
12615709-1	2003	Treatment of MCF-7 cells with the peroxisome proliferator-activated receptor (PPAR) gamma agonists ciglitazone or 15-deoxy-Delta 12,14-prostaglandin J2 resulted in a concentration- and time-dependent decrease of cyclin D1 and estrogen receptor (ER) alpha proteins, and this was accompanied by decreased cell proliferation and G(1)-G(0)--&gt;S-phase progression.	9-deoxy-delta-9-prostaglandin D2	134-151	cyclin D1	Homo sapiens	212-221
12615709-2	2003	Down-regulation of cyclin D1 and ER alpha by PPARgamma agonists was inhibited in cells cotreated with the proteasome inhibitors MG132 and PSII, but not in cells cotreated with the protease inhibitors calpain II and calpeptin.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	128-133	cyclin D1	Homo sapiens	19-28
12615709-3	2003	Moreover, after treatment of MCF-7 cells with 15-deoxy-Delta 12,14-prostaglandin J2 and immunoprecipitation with cyclin D1 or ER alpha antibodies, there was enhanced formation of ubiquitinated cyclin D1 and ER alpha bands.	15-deoxy-delta(12,14)-prostaglandin J2	46-83	cyclin D1	Homo sapiens	193-202
12393461-5	2003	Curcumin also down-regulated the expression of NF-kappaB-regulated gene products, including IkappaBalpha, Bcl-2, Bcl-x(L), cyclin D1, and interleukin-6.	Curcumin	0-8	cyclin D1	Homo sapiens	123-132
12614329-10	2003	In cultures treated with EGF, LY341495 was also able to reduce the stimulation of the mitogen-activated protein kinase (MAPK) pathway, as well as the induction of cyclin D1.	LY 341495	30-38	cyclin D1	Homo sapiens	163-172
12569141-1	2003	BACKGROUND: Altered cyclin D1 expression in advanced preinvasive lesions of the upper aerodigestive tract (UADT) is associated with an increased risk of developing cancer and histologic progression during and after combination biochemopreventive therapy (13-cis-retinoic acid, alpha-interferon, and alpha-tocopherol).	Isotretinoin	255-275	cyclin D1	Homo sapiens	20-29
12569141-1	2003	BACKGROUND: Altered cyclin D1 expression in advanced preinvasive lesions of the upper aerodigestive tract (UADT) is associated with an increased risk of developing cancer and histologic progression during and after combination biochemopreventive therapy (13-cis-retinoic acid, alpha-interferon, and alpha-tocopherol).	alpha-Tocopherol	299-315	cyclin D1	Homo sapiens	20-29
12569141-2	2003	Both alleles of the adenine (A)/guanine (G) cyclin D1 polymorphism located at nucleotide 870 encode two alternatively spliced transcripts, but the A allele preferentially encodes a protein with an extended half-life.	Adenine	20-27	cyclin D1	Homo sapiens	44-53
12569141-2	2003	Both alleles of the adenine (A)/guanine (G) cyclin D1 polymorphism located at nucleotide 870 encode two alternatively spliced transcripts, but the A allele preferentially encodes a protein with an extended half-life.	Guanine	32-39	cyclin D1	Homo sapiens	44-53
12586776-3	2003	The farnesyltransferase and geranylgeranyltransferase I inhibitors (FTI-277 and GGTI-298, respectively) antagonize estradiol-stimulated cell cycle progression, progesterone receptor, cyclin D1, and c-Myc expression.	FTI 277	68-75	cyclin D1	Homo sapiens	183-192
12586776-3	2003	The farnesyltransferase and geranylgeranyltransferase I inhibitors (FTI-277 and GGTI-298, respectively) antagonize estradiol-stimulated cell cycle progression, progesterone receptor, cyclin D1, and c-Myc expression.	Estradiol	115-124	cyclin D1	Homo sapiens	183-192
12612058-5	2003	However, cyclin D1 was a key estrogen-induced gene not expressed in response to tamoxifen or raloxifene but constitutively expressed in tamoxifen-resistant cells.	Tamoxifen	80-89	cyclin D1	Homo sapiens	9-18
12612881-6	2003	Cyclin D1 was overexpressed in 6% of TCs, 20% of ACs, 9.5% of LCNECs, and 1.3% of SCLCs.	9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide	37-40	cyclin D1	Homo sapiens	0-9
12612881-6	2003	Cyclin D1 was overexpressed in 6% of TCs, 20% of ACs, 9.5% of LCNECs, and 1.3% of SCLCs.	Aminocaproic Acid	49-52	cyclin D1	Homo sapiens	0-9
12612881-8	2003	Overall, the Rb pathway (Rb/P16(INK4)/cyclin D1) was altered more frequently in ACs than in TCs (P = 0.001) and more frequently in LCNECs than in ACs (P = 0.001).	Rubidium	13-15	cyclin D1	Homo sapiens	38-47
12612881-8	2003	Overall, the Rb pathway (Rb/P16(INK4)/cyclin D1) was altered more frequently in ACs than in TCs (P = 0.001) and more frequently in LCNECs than in ACs (P = 0.001).	9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide	92-95	cyclin D1	Homo sapiens	38-47
12612058-5	2003	However, cyclin D1 was a key estrogen-induced gene not expressed in response to tamoxifen or raloxifene but constitutively expressed in tamoxifen-resistant cells.	Tamoxifen	136-145	cyclin D1	Homo sapiens	9-18
14526425-7	2003	Sodium butyrate could down-regulate the mRNA expression of cyclin D1, but not affect its protein expression; down-regulate the protein expression of cyclin D3, but not affect its mRNA expression.	Butyric Acid	0-15	cyclin D1	Homo sapiens	59-68
12469199-0	2003	Quercetin regulates growth of Ishikawa cells through the suppression of EGF and cyclin D1.	Quercetin	0-9	cyclin D1	Homo sapiens	80-89
12469199-5	2003	The gene and protein expression data suggest that quercetin treatment (100 micro M) significantly decreased EGF and cyclin D1, whereas VEGF was up-regulated in Ishiwaka cell lines.	Quercetin	50-59	cyclin D1	Homo sapiens	116-125
12469199-7	2003	The present study suggests that quercetin can suppress proliferation of Ishikawa cells through down-regulation of EGF and cyclin D1.	Quercetin	32-41	cyclin D1	Homo sapiens	122-131
14526425-8	2003	Trichostatin A showed similar effects on cyclin D1 and D3 as sodium butyrate.	trichostatin A	0-14	cyclin D1	Homo sapiens	41-50
12469160-0	2003	Cyclin D1 expression and patient outcome after tamoxifen therapy in estrogen receptor positive metastatic breast cancer.	Tamoxifen	47-56	cyclin D1	Homo sapiens	0-9
12469160-2	2003	We executed this study to evaluate whether therapeutic response to tamoxifen varies with levels of cyclin D1 expression in 66 ER positive breast cancer patients having solitary bone metastasis.	Tamoxifen	67-76	cyclin D1	Homo sapiens	99-108
12469160-5	2003	Patients with cyclin D1-expressing tumors showed better response to tamoxifen but the difference was not statistically significant.	Tamoxifen	68-77	cyclin D1	Homo sapiens	14-23
12364325-6	2002	Nuclear accumulation of cyclin D1 and cell cycle progression were also observed when LiCl, a known inhibitor of GSK3beta, was added to E(2)-stimulated cells.	Lithium Chloride	85-89	cyclin D1	Homo sapiens	24-33
12457721-6	2003	Flavopiridol treatments also resulted in remarkable reductions of cyclin A, cyclin B, and cyclin D1 expressions.	alvocidib	0-12	cyclin D1	Homo sapiens	90-99
12528808-9	2003	Suppression of cyclin D1 by cyclin D1 antisense mRNA expression was associated with growth inhibition and an increase in chemosensitivity to fluoropyrimidines and platinum compounds.	fluoropyrimidines	141-158	cyclin D1	Homo sapiens	15-24
12528808-9	2003	Suppression of cyclin D1 by cyclin D1 antisense mRNA expression was associated with growth inhibition and an increase in chemosensitivity to fluoropyrimidines and platinum compounds.	fluoropyrimidines	141-158	cyclin D1	Homo sapiens	28-37
12528808-9	2003	Suppression of cyclin D1 by cyclin D1 antisense mRNA expression was associated with growth inhibition and an increase in chemosensitivity to fluoropyrimidines and platinum compounds.	Platinum	163-171	cyclin D1	Homo sapiens	15-24
12528808-9	2003	Suppression of cyclin D1 by cyclin D1 antisense mRNA expression was associated with growth inhibition and an increase in chemosensitivity to fluoropyrimidines and platinum compounds.	Platinum	163-171	cyclin D1	Homo sapiens	28-37
12359725-6	2002	Taken together, these data show a new role for ERK in G1 cell cycle progression: In addition to its role in stimulating cyclin D1 expression and nuclear translocation of CDK2, ERK regulates Thr-160 phosphorylation of CDK2-cyclin E.	Threonine	190-193	cyclin D1	Homo sapiens	120-129
12483537-0	2002	Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation.	Curcumin	0-8	cyclin D1	Homo sapiens	86-95
12483537-4	2002	It is possible that the effect of curcumin is mediated through the regulation of cyclin D1.	Curcumin	34-42	cyclin D1	Homo sapiens	81-90
12483537-5	2002	In the present report we show that inhibition of the proliferation of various prostate, breast and squamous cell carcinoma cell lines by curcumin correlated with the down-regulation of the expression of cyclin D1 protein.	Curcumin	137-145	cyclin D1	Homo sapiens	203-212
12483537-7	2002	The suppression of cyclin D1 by curcumin led to inhibition of CDK4-mediated phosphorylation of retinoblastoma protein.	Curcumin	32-40	cyclin D1	Homo sapiens	19-28
12483537-8	2002	We found that curcumin-induced down-regulation of cyclin D1 was inhibited by lactacystin, an inhibitor of 26S proteosome, suggesting that curcumin represses cyclin D1 expression by promoting proteolysis.	Curcumin	14-22	cyclin D1	Homo sapiens	50-59
12483537-8	2002	We found that curcumin-induced down-regulation of cyclin D1 was inhibited by lactacystin, an inhibitor of 26S proteosome, suggesting that curcumin represses cyclin D1 expression by promoting proteolysis.	Curcumin	14-22	cyclin D1	Homo sapiens	157-166
12483537-8	2002	We found that curcumin-induced down-regulation of cyclin D1 was inhibited by lactacystin, an inhibitor of 26S proteosome, suggesting that curcumin represses cyclin D1 expression by promoting proteolysis.	lactacystin	77-88	cyclin D1	Homo sapiens	50-59
12483537-8	2002	We found that curcumin-induced down-regulation of cyclin D1 was inhibited by lactacystin, an inhibitor of 26S proteosome, suggesting that curcumin represses cyclin D1 expression by promoting proteolysis.	lactacystin	77-88	cyclin D1	Homo sapiens	157-166
12483537-8	2002	We found that curcumin-induced down-regulation of cyclin D1 was inhibited by lactacystin, an inhibitor of 26S proteosome, suggesting that curcumin represses cyclin D1 expression by promoting proteolysis.	Curcumin	138-146	cyclin D1	Homo sapiens	50-59
12483537-8	2002	We found that curcumin-induced down-regulation of cyclin D1 was inhibited by lactacystin, an inhibitor of 26S proteosome, suggesting that curcumin represses cyclin D1 expression by promoting proteolysis.	Curcumin	138-146	cyclin D1	Homo sapiens	157-166
12368234-7	2002	Furthermore, Western-blot analysis of gamma-tocopherol treated cells showed decreased levels of cyclin D1 and cyclin E. Taken together, the results indicate that gamma-tocopherol inhibits cell cycle progression via reduction of cyclin D1 and cyclin E levels.	gamma-Tocopherol	38-54	cyclin D1	Homo sapiens	96-105
12483537-10	2002	Curcumin also inhibited the activity of the cyclin D1 promoter-dependent reporter gene expression.	Curcumin	0-8	cyclin D1	Homo sapiens	44-53
12483537-11	2002	Overall our results suggest that curcumin down-regulates cyclin D1 expression through activation of both transcriptional and post-transcriptional mechanisms, and this may contribute to the antiproliferative effects of curcumin against various cell types.	Curcumin	33-41	cyclin D1	Homo sapiens	57-66
12483537-11	2002	Overall our results suggest that curcumin down-regulates cyclin D1 expression through activation of both transcriptional and post-transcriptional mechanisms, and this may contribute to the antiproliferative effects of curcumin against various cell types.	Curcumin	218-226	cyclin D1	Homo sapiens	57-66
12368234-7	2002	Furthermore, Western-blot analysis of gamma-tocopherol treated cells showed decreased levels of cyclin D1 and cyclin E. Taken together, the results indicate that gamma-tocopherol inhibits cell cycle progression via reduction of cyclin D1 and cyclin E levels.	gamma-Tocopherol	38-54	cyclin D1	Homo sapiens	228-237
12368234-7	2002	Furthermore, Western-blot analysis of gamma-tocopherol treated cells showed decreased levels of cyclin D1 and cyclin E. Taken together, the results indicate that gamma-tocopherol inhibits cell cycle progression via reduction of cyclin D1 and cyclin E levels.	gamma-Tocopherol	162-178	cyclin D1	Homo sapiens	96-105
12368234-7	2002	Furthermore, Western-blot analysis of gamma-tocopherol treated cells showed decreased levels of cyclin D1 and cyclin E. Taken together, the results indicate that gamma-tocopherol inhibits cell cycle progression via reduction of cyclin D1 and cyclin E levels.	gamma-Tocopherol	162-178	cyclin D1	Homo sapiens	228-237
12429973-6	2002	Tetrandrine-induced growth inhibition was associated with induction of Cdk inhibitor p21, inhibition of cyclin D1 and activation of caspase-3.	tetrandrine	0-11	cyclin D1	Homo sapiens	104-113
12444159-9	2002	Piceatannol abrogated the expression of TNF-induced NF-kappaB-dependent reporter gene and of matrix metalloprotease-9, cyclooxygenase-2, and cyclin D1.	3,3',4,5'-tetrahydroxystilbene	0-11	cyclin D1	Homo sapiens	141-150
12444551-7	2002	Transfection of a mutant cyclin D1 (cyclin D1-KE) that was unable to bind CDK4 and was reported to transactivate ER in the presence of ICI 182780, could not stimulate proliferation in ICI 182780 treated cells.	Fulvestrant	135-145	cyclin D1	Homo sapiens	36-45
12372763-9	2002	Serum, ionomycin, and forskolin all caused a rapid decline in cyclin D1 levels, but only serum effected a subsequent increase, indicative of cell cycle progression.	Ionomycin	7-16	cyclin D1	Homo sapiens	62-71
12444551-7	2002	Transfection of a mutant cyclin D1 (cyclin D1-KE) that was unable to bind CDK4 and was reported to transactivate ER in the presence of ICI 182780, could not stimulate proliferation in ICI 182780 treated cells.	Fulvestrant	135-145	cyclin D1	Homo sapiens	25-34
12439750-0	2002	Galectin-3 enhances cyclin D(1) promoter activity through SP1 and a cAMP-responsive element in human breast epithelial cells.	Cyclic AMP	68-72	cyclin D1	Homo sapiens	20-31
12372763-9	2002	Serum, ionomycin, and forskolin all caused a rapid decline in cyclin D1 levels, but only serum effected a subsequent increase, indicative of cell cycle progression.	Colforsin	22-31	cyclin D1	Homo sapiens	62-71
12392815-8	2002	A consequence of reduced beta-catenin in SW480 cells was that exisulind, CP461, and CP248 caused a concentration- and time-dependent decrease in cyclin D1 levels (EC(50) approximately 300 microM, 1 microM, and &lt;1 microM, respectively) in 4 hr.	sulindac sulfone	84-89	cyclin D1	Homo sapiens	145-154
12397020-4	2002	This CO-induced cell growth arrest of HASMC was associated with upregulation of p21 and downregulation of cyclin D1 expression.	hasmc	38-43	cyclin D1	Homo sapiens	106-115
12411587-2	2002	We used a real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR) method to quantify levels of cyclin D1, CD20, and cyclophilin A mRNA in manually microdissected, paraffin-embedded tissue sections using an ABI 7700 qRT-PCR system.	Paraffin	188-196	cyclin D1	Homo sapiens	120-129
12401721-6	2002	In vivo and in cultured mesangial cells, high glucose resulted in persistent partial phosphorylation of RB, an event catalyzed specifically by cyclin D1-cdk4.	Glucose	46-53	cyclin D1	Homo sapiens	143-157
12504222-7	2002	In vitro, rofecoxib decreased gene expression of cyclin D1/PRAD1, a key component of cell cycle progression, while increasing expression of several cell cycle arrest genes, including p21/WAF1, p33/ING, GADD34, and GADD45 (P &lt; 0.05).	rofecoxib	10-19	cyclin D1	Homo sapiens	49-58
12504222-7	2002	In vitro, rofecoxib decreased gene expression of cyclin D1/PRAD1, a key component of cell cycle progression, while increasing expression of several cell cycle arrest genes, including p21/WAF1, p33/ING, GADD34, and GADD45 (P &lt; 0.05).	rofecoxib	10-19	cyclin D1	Homo sapiens	59-64
12404122-5	2002	Luciferase assays of promoter activity indicate that B-myb-dependent transactivation is enhanced in LAN-5 cells treated with retinoic acid (RA) for 24 h. The enhancement is independent from cyclin A but is suppressed by a degradation-resistant mutant form of cyclin D1.	Tretinoin	125-138	cyclin D1	Homo sapiens	259-268
12404122-5	2002	Luciferase assays of promoter activity indicate that B-myb-dependent transactivation is enhanced in LAN-5 cells treated with retinoic acid (RA) for 24 h. The enhancement is independent from cyclin A but is suppressed by a degradation-resistant mutant form of cyclin D1.	Tretinoin	140-142	cyclin D1	Homo sapiens	259-268
12404122-6	2002	The importance of cyclin D1 in controlling B-myb activity is further suggested by co-immunoprecipitation experiments, showing that the amount of cyclin D1 co-immunoprecipitated with B-myb decreased after RA treatment.	Tretinoin	204-206	cyclin D1	Homo sapiens	18-27
12404122-6	2002	The importance of cyclin D1 in controlling B-myb activity is further suggested by co-immunoprecipitation experiments, showing that the amount of cyclin D1 co-immunoprecipitated with B-myb decreased after RA treatment.	Tretinoin	204-206	cyclin D1	Homo sapiens	145-154
12391146-2	2002	A cyclic AMP-responsive element (CRE), located upstream of the cyclin D1 mRNA start site, integrates mitogenic signals that target the CRE-binding factor CREB, which can recruit the transcriptional coactivator CREB-binding protein (CBP).	Cyclic AMP	2-12	cyclin D1	Homo sapiens	63-72
12234612-9	2002	After a 24-hr treatment with 5 microM SU9516, cyclin D1 and cdk2 levels decreased by 10-60%.	SU 9516	38-44	cyclin D1	Homo sapiens	46-55
12379472-4	2002	In MCF-7 cells, leptin and high glucose stimulated cell proliferation as demonstrated by the increases in DNA synthesis and expression of cdk2 and cyclin D1.	Glucose	32-39	cyclin D1	Homo sapiens	147-156
12234612-10	2002	These findings delineate a previously undescribed mechanism for SU9516-mediated cell growth arrest through down-regulation of cyclin D1, inhibition of cdk2 levels and activity, and pan-sequestration of E2F.	SU 9516	64-70	cyclin D1	Homo sapiens	126-135
12572356-5	2002	Western blot analysis showed tea polyphenols and tea pigments significantly inhibited the expression of cyclin D1 protein and induced higher expression of P21WAFI/CIPI protein.	Polyphenols	33-44	cyclin D1	Homo sapiens	104-113
12376514-6	2002	We measured cyclin D1 status in paraffin-embedded, archived tissue from 78.8% of the breast cancer cases using immunohistochemistry.	Paraffin	32-40	cyclin D1	Homo sapiens	12-21
12388769-0	2002	Distinct nongenomic signal transduction pathways controlled by 17beta-estradiol regulate DNA synthesis and cyclin D(1) gene transcription in HepG2 cells.	Estradiol	63-79	cyclin D1	Homo sapiens	107-118
12354750-0	2002	Translational regulation of cyclin D1 by 15-deoxy-delta(12,14)-prostaglandin J(2).	Prostaglandins	63-76	cyclin D1	Homo sapiens	28-37
12242656-15	2002	In the presence of LY294002, cell-cycle arrest in G0/G1 was observed, p27(Kip1) protein expression was up-regulated whereas the expression of both Skp2 and cyclin D1 dramatically diminished.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	cyclin D1	Homo sapiens	156-165
12241561-6	2002	The selective suppression of HIV-1 transcription by the cyclin-dependent kinase inhibitor, flavopiridol, abrogated cyclin D1 expression, underlying the requirement for HIV-1 encoded products to induce cyclin D1.	alvocidib	91-103	cyclin D1	Homo sapiens	115-124
12241561-6	2002	The selective suppression of HIV-1 transcription by the cyclin-dependent kinase inhibitor, flavopiridol, abrogated cyclin D1 expression, underlying the requirement for HIV-1 encoded products to induce cyclin D1.	alvocidib	91-103	cyclin D1	Homo sapiens	201-210
12196377-10	2002	There was a statistically significant inverse correlation between the expression of beta-catenine and cyclin D1, as well as p53 and p27 (P &lt;0.05).	beta-catenine	84-97	cyclin D1	Homo sapiens	102-111
12231535-0	2002	Identification of cyclin D1 mRNA overexpression in B-cell neoplasias by real-time reverse transcription-PCR of microdissected paraffin sections.	Paraffin	126-134	cyclin D1	Homo sapiens	18-27
12167712-0	2002	Gamma interferon and cadmium treatments modulate eukaryotic initiation factor 4E-dependent mRNA transport of cyclin D1 in a PML-dependent manner.	Cadmium	21-28	cyclin D1	Homo sapiens	109-118
12167712-6	2002	Here we report that cadmium treatment, which disperses PML nuclear bodies, leaves eIF4E bodies intact, leading to increased transport of cyclin D1 mRNA and increased cyclin D1 protein levels.	Cadmium	20-27	cyclin D1	Homo sapiens	137-146
12167712-6	2002	Here we report that cadmium treatment, which disperses PML nuclear bodies, leaves eIF4E bodies intact, leading to increased transport of cyclin D1 mRNA and increased cyclin D1 protein levels.	Cadmium	20-27	cyclin D1	Homo sapiens	166-175
12167712-7	2002	Removal of cadmium allows PML to reassociate with eIF4E nuclear bodies, leading to decreased cyclin D1 transport and reduced cyclin D1 protein levels.	Cadmium	11-18	cyclin D1	Homo sapiens	93-102
12167712-7	2002	Removal of cadmium allows PML to reassociate with eIF4E nuclear bodies, leading to decreased cyclin D1 transport and reduced cyclin D1 protein levels.	Cadmium	11-18	cyclin D1	Homo sapiens	125-134
12354750-2	2002	Treatment of MCF-7 breast cancer cells with the cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) results in rapid down-regulation of cyclin D1 protein expression and growth arrest in the G(0)/G(1) phase of the cell cycle.	cyclopentenone	48-62	cyclin D1	Homo sapiens	155-164
12354750-2	2002	Treatment of MCF-7 breast cancer cells with the cyclopentenone prostaglandin 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) results in rapid down-regulation of cyclin D1 protein expression and growth arrest in the G(0)/G(1) phase of the cell cycle.	prostaglandin 15-deoxy-delta	63-91	cyclin D1	Homo sapiens	155-164
12354750-3	2002	15d-PGJ(2) also down-regulates the expression of cyclin D1 mRNA; however, this effect is delayed relative to the effect on cyclin D1 protein levels, suggesting that the regulation of cyclin D1 occurs at least partly at the level of translation or protein turnover.	-pgj	3-7	cyclin D1	Homo sapiens	49-58
12354750-4	2002	Treatment of MCF-7 cells with 15d-PGJ(2) leads to a rapid increase in the phosphorylation of protein synthesis initiation factor eukaryotic initiation factor 2alpha (eIF-2alpha) and a shift of cyclin D1 mRNA from the polysome-associated to free mRNA fraction, indicating that 15d-PGJ(2) inhibits the initiation of cyclin D1 mRNA translation.	15d-pgj	30-37	cyclin D1	Homo sapiens	193-202
12354750-4	2002	Treatment of MCF-7 cells with 15d-PGJ(2) leads to a rapid increase in the phosphorylation of protein synthesis initiation factor eukaryotic initiation factor 2alpha (eIF-2alpha) and a shift of cyclin D1 mRNA from the polysome-associated to free mRNA fraction, indicating that 15d-PGJ(2) inhibits the initiation of cyclin D1 mRNA translation.	15d-pgj	30-37	cyclin D1	Homo sapiens	314-323
12154027-11	2002	DNA microarray analysis of livers from ET-743-treated animals showed a dramatic increase in the expression of ATP binding cassette transport genes Abcb1a and Abcb1b, which impart resistance to anticancer drugs, and of Cdc2a and Ccnd1, the rodent homologues of human cell cycle genes CDC2 and cyclin D1, respectively.	Trabectedin	39-45	cyclin D1	Homo sapiens	228-233
12174089-7	2002	1,25(OH)2D3 has a major inhibitory effect on the G1/S checkpoint of the cell cycle by upregulating the cyclin dependent kinase inhibitors p27 and p21, and by inhibiting cyclin D1.	Calcitriol	0-11	cyclin D1	Homo sapiens	169-178
12154027-11	2002	DNA microarray analysis of livers from ET-743-treated animals showed a dramatic increase in the expression of ATP binding cassette transport genes Abcb1a and Abcb1b, which impart resistance to anticancer drugs, and of Cdc2a and Ccnd1, the rodent homologues of human cell cycle genes CDC2 and cyclin D1, respectively.	Trabectedin	39-45	cyclin D1	Homo sapiens	292-301
12154060-4	2002	Other contributing effects of morphine include activation of the survival signal PKB/Akt, inhibition of apoptosis, and promotion of cell cycle progression by increasing cyclin D1.	Morphine	30-38	cyclin D1	Homo sapiens	169-178
12154027-11	2002	DNA microarray analysis of livers from ET-743-treated animals showed a dramatic increase in the expression of ATP binding cassette transport genes Abcb1a and Abcb1b, which impart resistance to anticancer drugs, and of Cdc2a and Ccnd1, the rodent homologues of human cell cycle genes CDC2 and cyclin D1, respectively.	Adenosine Triphosphate	110-113	cyclin D1	Homo sapiens	228-233
12154027-11	2002	DNA microarray analysis of livers from ET-743-treated animals showed a dramatic increase in the expression of ATP binding cassette transport genes Abcb1a and Abcb1b, which impart resistance to anticancer drugs, and of Cdc2a and Ccnd1, the rodent homologues of human cell cycle genes CDC2 and cyclin D1, respectively.	Adenosine Triphosphate	110-113	cyclin D1	Homo sapiens	292-301
12124333-0	2002	Growth inhibition of human hepatoma cells by acyclic retinoid is associated with induction of p21(CIP1) and inhibition of expression of cyclin D1.	Retinoids	53-61	cyclin D1	Homo sapiens	136-145
12240952-6	2002	Cyclosporin A further targeted cyclin D1 transcription.	Cyclosporine	0-13	cyclin D1	Homo sapiens	31-40
12175534-4	2002	Analysis of G1 cell cycle regulators expression revealed that monoterpenes increased expression of cdk inhibitor p21(Waf1/Cip1) and cyclin E, and decreased expression of cyclin D1, cyclin-dependent kinase (cdk) 4 and cdk2.	Monoterpenes	62-74	cyclin D1	Homo sapiens	170-179
12175534-5	2002	Our results suggest that monoterpenes induce growth arrest of colon cancer cells through the up-regulation of p21(Waf1/Cip1) and the down-expression of cyclin D1 and its partner cdk4.	Monoterpenes	25-37	cyclin D1	Homo sapiens	152-161
12479366-0	2002	Flavopiridol and trastuzumab synergistically inhibit proliferation of breast cancer cells: association with selective cooperative inhibition of cyclin D1-dependent kinase and Akt signaling pathways.	alvocidib	0-12	cyclin D1	Homo sapiens	144-153
11986316-5	2002	In each case, ER activation at the cyclin D1 promoter is mediated by both the cyclic AMP-response element and the activating protein-1 site, which play partly redundant roles.	Cyclic AMP	78-88	cyclin D1	Homo sapiens	35-44
12150453-0	2002	Overexpression of cyclin D1 enhances taxol induced mitotic death in MCF7 cells.	Paclitaxel	37-42	cyclin D1	Homo sapiens	18-27
12150453-2	2002	A moderate overexpression of ectopic cyclin D1 accelerated these G2/M associated events and resulted in a reduced clonogenic survival upon taxol treatment.	Paclitaxel	139-144	cyclin D1	Homo sapiens	37-46
12150453-3	2002	Taxol treatment resulted in elevated expression of p53 and of p21, which was more pronounced and persistent in cyclin D1 overexpressing cells.	Paclitaxel	0-5	cyclin D1	Homo sapiens	111-120
12150453-4	2002	Overexpression of cyclin D1 altered sensitivity to taxol by modulating exit from mitosis, which is controlled by p21.	Paclitaxel	51-56	cyclin D1	Homo sapiens	18-27
12150453-5	2002	These results indicate that overexpression of cyclin D1 sensitizes MCF7 cells to treatment with taxol.	Paclitaxel	96-101	cyclin D1	Homo sapiens	46-55
12000762-6	2002	RA also reduces the activity of an AP-1 and TCF-sensitive cyclin D1 reporter in SKBR3 cells in a manner that is independent of the TCF site.	Tretinoin	0-2	cyclin D1	Homo sapiens	58-67
12000762-7	2002	In contrast, in SW480 cells, which have high levels of beta-catenin/TCF signaling, the activity and retinoid responsiveness of the cyclin D1 promoter was markedly inhibited by mutation of the TCF site.	Retinoids	100-108	cyclin D1	Homo sapiens	131-140
12164932-4	2002	Ganglioside deficiency also increases expression of cyclins D1 and E, promoting cell cycle progression from G1 phase to S phase.	Gangliosides	0-11	cyclin D1	Homo sapiens	52-68
12479366-7	2002	In SKBR3 cells, a combination of trastuzumab and flavopiridol inhibited the Ras-MAPK-Akt pathway, decreased cyclin D1 abundance, and kinase activity to a greater extent than either drug alone.	alvocidib	49-61	cyclin D1	Homo sapiens	108-117
11979431-11	2002	Moreover, the disaccharide caused increased expression of cyclin D1 and of activated MAP kinase, again reduced in the presence of the inhibitor AG825.	Disaccharides	14-26	cyclin D1	Homo sapiens	58-67
11992683-9	2002	HPMA-hydrogels containing DOX were significantly more effective in inhibition of Bcl1 leukemia in comparison with free DOX or non-targeted polymeric drug (PK1).	Doxorubicin	26-29	cyclin D1	Homo sapiens	81-85
12111702-7	2002	Melatonin and 2-iodomelatonin (a melatonin receptor agonist) attenuated EGF-stimulated increases in LNCaP cell proliferation and cyclin D1 levels.	Melatonin	0-9	cyclin D1	Homo sapiens	129-138
12111702-7	2002	Melatonin and 2-iodomelatonin (a melatonin receptor agonist) attenuated EGF-stimulated increases in LNCaP cell proliferation and cyclin D1 levels.	2-iodomelatonin	14-29	cyclin D1	Homo sapiens	129-138
11979431-11	2002	Moreover, the disaccharide caused increased expression of cyclin D1 and of activated MAP kinase, again reduced in the presence of the inhibitor AG825.	tyrphostin AG825	144-149	cyclin D1	Homo sapiens	58-67
11978170-6	2002	In addition to direct CDK inhibition, flavopiridol also exhibited other features such as inducing apoptosis in many cancer cell lines, decreasing cyclin D1 concentration, and inhibiting angiogenesis.	alvocidib	38-50	cyclin D1	Homo sapiens	146-155
11867622-5	2002	The specific CYP 2C9 inhibitor, sulfaphenazole, prevented both the enhanced cell proliferation and up-regulation of cyclin D1.	Sulfaphenazole	32-46	cyclin D1	Homo sapiens	116-125
12479270-15	2002	Silibinin-treated cells showed up to 2.4- and 3.6-fold increases in Cip1/p21 and Kip1/p27 levels, respectively, and a decrease in CDK2 (80%), CDK4 (98%), and cyclin D1 (60%).	Silybin	0-9	cyclin D1	Homo sapiens	158-167
12112322-4	2002	The activity of cyclin E/Cdk2 complexes from zearalenone-treated lysates was inhibited in vitro by recombinant p27(KIP1), and this inhibition was relieved by the addition of recombinant cyclin D1/Cdk4 complexes.	Zearalenone	45-56	cyclin D1	Homo sapiens	186-195
11980635-6	2002	Dietary genistein negated/overwhelmed the inhibitory effect of TAM on MCF-7 tumor growth, lowered E2 level in plasma, and increased expression of E-responsive genes (e.g., pS2, PR, and cyclin D1).	Genistein	8-17	cyclin D1	Homo sapiens	185-194
11940657-8	2002	These data suggest a model in which TGF-beta modulates p27 phosphorylation from its cyclin D1-bound assembly phosphoform to an alternate form that binds tightly to inhibit cyclin E1-cdk2.	phosphoform	109-120	cyclin D1	Homo sapiens	84-93
11956082-0	2002	Rate-limiting effects of Cyclin D1 in transformation by ErbB2 predicts synergy between herceptin and flavopiridol.	alvocidib	101-113	cyclin D1	Homo sapiens	25-34
11956082-4	2002	Drugs active against erbB2 and cyclin D1 (Herceptin and flavopiridol) were synergistically cytotoxic against erbB2-positive breast cancer cell lines.	alvocidib	56-68	cyclin D1	Homo sapiens	31-40
12042072-2	2002	By quantitative RT-PCR, Northern blotting, and Western blotting analyses, we found that the expression of the CDK inhibitors p18 and p21 was upregulated at the early and late stages of heme-induced erythroid differentiation of K562 cells, respectively, while the expression of cyclin D1 was downregulated.	Heme	185-189	cyclin D1	Homo sapiens	277-286
11900573-5	2002	DESIGN: Cyclin D1 immunohistochemical analysis was used to evaluate 108 fixed, paraffin-embedded endometrial biopsy specimens and uterine resections obtained from 108 patients.	Paraffin	79-87	cyclin D1	Homo sapiens	8-17
12153166-2	2002	Flavopiridol inhibits the cyclin-dependent kinase (CDK)4-cyclin D1 complex and induces apoptosis in lymphoma cell lines.	alvocidib	0-12	cyclin D1	Homo sapiens	57-66
11884610-9	2002	In model p107 spacer region peptides, phosphorylation of S640 by cyclin D1/Cdk4 is strictly dependent upon an intact RXL motif, but phosphorylation of this site in the absence of an RXL motif can be partially restored by replacement of S643 by arginine.	4-Chlorobenzenesulfonyl chloride	236-240	cyclin D1	Homo sapiens	65-74
11884610-6	2002	While coexpression of cyclin D1/Cdk4 can reverse the cell cycle arrest properties of p107 in Saos-2 cells, we find that p107 in which the Lys-Arg-Arg-Leu sequence of the RXL motif is replaced by four alanine residues is largely refractory to inactivation by cyclin D/Cdk4, indicating a role for this motif in p107 inactivation without a requirement for its tight interaction with cyclin D1/Cdk4.	Lysine	138-141	cyclin D1	Homo sapiens	22-31
11884610-9	2002	In model p107 spacer region peptides, phosphorylation of S640 by cyclin D1/Cdk4 is strictly dependent upon an intact RXL motif, but phosphorylation of this site in the absence of an RXL motif can be partially restored by replacement of S643 by arginine.	Arginine	244-252	cyclin D1	Homo sapiens	65-74
11884610-6	2002	While coexpression of cyclin D1/Cdk4 can reverse the cell cycle arrest properties of p107 in Saos-2 cells, we find that p107 in which the Lys-Arg-Arg-Leu sequence of the RXL motif is replaced by four alanine residues is largely refractory to inactivation by cyclin D/Cdk4, indicating a role for this motif in p107 inactivation without a requirement for its tight interaction with cyclin D1/Cdk4.	Arginine	142-145	cyclin D1	Homo sapiens	22-31
12561543-0	2002	[Inhibitory effects of genistein on the synthesis of DNA and the protein expression of cyclin D1 in human gastric carcinoma cell-line].	Genistein	23-32	cyclin D1	Homo sapiens	87-96
11884610-6	2002	While coexpression of cyclin D1/Cdk4 can reverse the cell cycle arrest properties of p107 in Saos-2 cells, we find that p107 in which the Lys-Arg-Arg-Leu sequence of the RXL motif is replaced by four alanine residues is largely refractory to inactivation by cyclin D/Cdk4, indicating a role for this motif in p107 inactivation without a requirement for its tight interaction with cyclin D1/Cdk4.	Arginine	146-149	cyclin D1	Homo sapiens	22-31
11884610-6	2002	While coexpression of cyclin D1/Cdk4 can reverse the cell cycle arrest properties of p107 in Saos-2 cells, we find that p107 in which the Lys-Arg-Arg-Leu sequence of the RXL motif is replaced by four alanine residues is largely refractory to inactivation by cyclin D/Cdk4, indicating a role for this motif in p107 inactivation without a requirement for its tight interaction with cyclin D1/Cdk4.	Leucine	150-153	cyclin D1	Homo sapiens	22-31
12561543-5	2002	The above mentioned results indicate that genistein inhibits the growth of gastric carcinoma cells and the possible mechanism of this inhibition might be resulted from inhibiting the synthesis of DNA and the protein expression of cyclin D1.	Genistein	42-51	cyclin D1	Homo sapiens	230-239
11989975-4	2002	However, in the HT-29 cells pre-treated with PI3K inhibitor, LY294002, zinc induced further the p21(CiP/WAF) induction whereas abrogated cyclin D1 induction.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	61-69	cyclin D1	Homo sapiens	137-146
11948404-0	2002	Cyclopentenone causes cell cycle arrest and represses cyclin D1 promoter activity in MCF-7 breast cancer cells.	cyclopentenone	0-14	cyclin D1	Homo sapiens	54-63
11948404-4	2002	Growth arrest of the cyclopentenone-treated cells in G1 was associated with changes in the levels of several proteins that control the cell cycle, including a dramatic decrease in cyclin D1 protein expression.	cyclopentenone	21-35	cyclin D1	Homo sapiens	180-189
11948404-5	2002	Cyclopentenone also decreased the abundance of cyclin D1 mRNA and nuclear transcripts, indicating that it regulated cyclin D1 expression at the transcriptional level.	cyclopentenone	0-14	cyclin D1	Homo sapiens	47-56
11788593-10	2002	Simultaneous treatment with EGF and a RAR-selective retinoid inhibits both phases of ERK1/2 activation, completely eliminates the cyclin D1 induction, and suppresses EGF-dependent cell proliferation.	Retinoids	52-60	cyclin D1	Homo sapiens	130-139
11948404-5	2002	Cyclopentenone also decreased the abundance of cyclin D1 mRNA and nuclear transcripts, indicating that it regulated cyclin D1 expression at the transcriptional level.	cyclopentenone	0-14	cyclin D1	Homo sapiens	116-125
11948404-6	2002	Cyclopentenone selectively inhibited the activity of the cyclin D1 and cyclin A promoters but not the activity of several other control promoters.	cyclopentenone	0-14	cyclin D1	Homo sapiens	57-66
11948404-7	2002	Deletion analysis indicated that the cyclopentenone response element was located in the cyclin D1 core promoter.	cyclopentenone	37-51	cyclin D1	Homo sapiens	88-97
11948404-11	2002	The overall results suggest that cyclopentenone interferes with the transcription initiation complex that assembles over the cyclin D1 initiator element, leading to selective inhibition of cyclin D1 gene transcription.	cyclopentenone	33-47	cyclin D1	Homo sapiens	125-134
11948404-11	2002	The overall results suggest that cyclopentenone interferes with the transcription initiation complex that assembles over the cyclin D1 initiator element, leading to selective inhibition of cyclin D1 gene transcription.	cyclopentenone	33-47	cyclin D1	Homo sapiens	189-198
11920593-5	2002	Immunoreactivity for monoclonal anti-cyclinD1 antibody (clone DCS-6) with paraffin-embedded carcinoma tissues was investigated using a labeled streptavidin-biotin method.	Paraffin	74-82	cyclin D1	Homo sapiens	37-45
11920593-5	2002	Immunoreactivity for monoclonal anti-cyclinD1 antibody (clone DCS-6) with paraffin-embedded carcinoma tissues was investigated using a labeled streptavidin-biotin method.	Biotin	156-162	cyclin D1	Homo sapiens	37-45
11857351-3	2002	The specificity of action of the drug was supported by the selective inhibition of the phosphorylation of cyclin-dependent kinase (cdk) substrates such as Rb and cyclin E. The cell contents of cyclins D1 and E were lower in cells incubated with purvalanol A compared to controls, but the level of the cdk inhibitory protein p21(WAF1/CIP1) was increased, indicating that the drug did not cause a general inhibition of gene expression.	6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine	245-257	cyclin D1	Homo sapiens	193-209
11751903-6	2002	The ability of p21(Cip1) to inhibit cyclin D1 nuclear export correlates with its ability to bind to Thr-286-phosphorylated cyclin D1 and thereby prevents cyclin D1.CRM1 association.	Threonine	100-103	cyclin D1	Homo sapiens	36-45
11751903-6	2002	The ability of p21(Cip1) to inhibit cyclin D1 nuclear export correlates with its ability to bind to Thr-286-phosphorylated cyclin D1 and thereby prevents cyclin D1.CRM1 association.	Threonine	100-103	cyclin D1	Homo sapiens	123-132
11751903-6	2002	The ability of p21(Cip1) to inhibit cyclin D1 nuclear export correlates with its ability to bind to Thr-286-phosphorylated cyclin D1 and thereby prevents cyclin D1.CRM1 association.	Threonine	100-103	cyclin D1	Homo sapiens	123-132
11895924-9	2002	Furthermore, using a reverse transcription-PCR-based assay, only a higher dose of resveratrol (300 microM) appeared to decrease cyclin D1 mRNA.	Resveratrol	82-93	cyclin D1	Homo sapiens	128-137
11836565-4	2002	TGF-beta1 intensified the decreased expression of CDK2, CDK4, CDK6 and cyclin D1 in EB1089-treated NCI-H929 cells.	seocalcitol	84-90	cyclin D1	Homo sapiens	71-80
11836618-1	2002	Overexpression and amplification of cyclin D1 were investigated by immunohistochemistry and differential polymerase chain reaction (dPCR) in 440 formalin-fixed primary breast carcinoma tissues.	Formaldehyde	145-153	cyclin D1	Homo sapiens	36-45
11756231-8	2002	Cyclin D1 promoter analysis revealed that indomethacin disrupted formation of a beta-catenin-TCF-4-DNA complex.	Indomethacin	42-54	cyclin D1	Homo sapiens	0-9
11842228-5	2002	We now show that the sEH inhibitor 1-cyclohexyl-3-dodecyl urea (CDU) inhibits human VSM cell proliferation in a dose-dependent manner and is associated with a decrease in the level of cyclin D1.	1-cyclohexyl-3-dodecylurea	35-62	cyclin D1	Homo sapiens	184-193
11842228-5	2002	We now show that the sEH inhibitor 1-cyclohexyl-3-dodecyl urea (CDU) inhibits human VSM cell proliferation in a dose-dependent manner and is associated with a decrease in the level of cyclin D1.	1-cyclohexyl-3-dodecylurea	64-67	cyclin D1	Homo sapiens	184-193
11895107-5	2002	Of the G1 cyclins tested, troglitazone specifically reduced the expression of cyclin D1 mRNA and the corresponding protein and this effect was also additive with 9-cis RA.	Troglitazone	26-38	cyclin D1	Homo sapiens	78-87
11895107-5	2002	Of the G1 cyclins tested, troglitazone specifically reduced the expression of cyclin D1 mRNA and the corresponding protein and this effect was also additive with 9-cis RA.	Radium	168-170	cyclin D1	Homo sapiens	78-87
11798189-0	2002	p53 inhibits adriamycin-induced down-regulation of cyclin D1 expression in human cancer cells.	Doxorubicin	13-23	cyclin D1	Homo sapiens	51-60
11798189-4	2002	Here we show that infection with an adenovirus vector expressing the wild-type p53 gene (Ad-p53) caused an increase in cyclin D1 protein levels in human colorectal cancer cell lines DLD-1 and SW620; treatment with the anti-cancer drug adriamycin, however, down-regulated their cyclin D1 protein expression in a dose-dependent manner.	Doxorubicin	235-245	cyclin D1	Homo sapiens	119-128
11798189-5	2002	The suppression of cyclin D1 expression following adriamycin treatment could be blocked by simultaneous Ad-p53 infection.	Doxorubicin	50-60	cyclin D1	Homo sapiens	19-28
11798189-6	2002	Furthermore, DLD-1 and SW620 cells transfected with the cyclin D1 expression construct displayed increased sensitivity to adriamycin compared to that of the vector-transfected control.	Doxorubicin	122-132	cyclin D1	Homo sapiens	56-65
11787050-6	2002	Treatment of PI3K inhibitor LY294002 and the MAP kinase inhibitor PD098059, but not p38 inhibitor SB203580, effectively blocks IGF-1-induced upregulation of Pin1, cyclin D1 and RB phosphorylation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	cyclin D1	Homo sapiens	163-172
12630765-8	2002	Treatment of BxPC-3 cells with 15d-PGJ2 resulted in a time-dependent decrease in cyclin D1 expression associated with a concomitant induction of p21waf1 and p27kip1.	15-deoxy-delta(12,14)-prostaglandin J2	31-39	cyclin D1	Homo sapiens	81-90
11787050-6	2002	Treatment of PI3K inhibitor LY294002 and the MAP kinase inhibitor PD098059, but not p38 inhibitor SB203580, effectively blocks IGF-1-induced upregulation of Pin1, cyclin D1 and RB phosphorylation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	66-74	cyclin D1	Homo sapiens	163-172
11773438-6	2002	The expression of cyclin D1, a critical regulator of the G1/S transition, was significantly increased by PRL and was associated with hyperphosphorylation of retinoblastoma protein at Ser(780).	Serine	183-186	cyclin D1	Homo sapiens	18-27
11595732-2	2001	We show here that the decrease in D-type cyclin levels observed following ATRA treatment correlates with an increase in the rate of cyclin D1 ubiquitylation in both T-47D and MCF-7 breast cancer cell lines.	Tretinoin	74-78	cyclin D1	Homo sapiens	132-141
11977632-3	2002	The expressions of p53, p16 and cyclin D1 were stained by indirect immunofluorescence of fluorescein isothiocyanate(FTTC), which were detected by flow cytometry (FCM).	Fluorescein-5-isothiocyanate	89-115	cyclin D1	Homo sapiens	32-41
11977632-3	2002	The expressions of p53, p16 and cyclin D1 were stained by indirect immunofluorescence of fluorescein isothiocyanate(FTTC), which were detected by flow cytometry (FCM).	fttc	116-120	cyclin D1	Homo sapiens	32-41
11595732-8	2001	We found that the mechanism of ATRA-induced ubiquitylation of cyclin D1 and Skp2 is independent of CUL-1 expression and that ATRA can rescue cyclin D1 degradation in the uterine cell line SK-UT-1, where D-type cyclins are stabilized due to a specific defect in proteolysis.	Tretinoin	31-35	cyclin D1	Homo sapiens	62-71
11595732-8	2001	We found that the mechanism of ATRA-induced ubiquitylation of cyclin D1 and Skp2 is independent of CUL-1 expression and that ATRA can rescue cyclin D1 degradation in the uterine cell line SK-UT-1, where D-type cyclins are stabilized due to a specific defect in proteolysis.	Tretinoin	31-35	cyclin D1	Homo sapiens	141-150
11595732-8	2001	We found that the mechanism of ATRA-induced ubiquitylation of cyclin D1 and Skp2 is independent of CUL-1 expression and that ATRA can rescue cyclin D1 degradation in the uterine cell line SK-UT-1, where D-type cyclins are stabilized due to a specific defect in proteolysis.	Tretinoin	125-129	cyclin D1	Homo sapiens	141-150
11795432-6	2001	RA triggered G1 arrest at least partly through proteasome-dependent degradation of cyclin D1.	Tretinoin	0-2	cyclin D1	Homo sapiens	83-92
11795432-8	2001	To confirm that a specific proteolysis pathway was induced by RA-treatment, a degradation assay was established using in vitro translated cyclin D1 and cellular extracts from RA-treated or untreated human bronchial epithelial cells.	Tretinoin	62-64	cyclin D1	Homo sapiens	138-147
11795432-9	2001	Incubation of RA-treated but not the control cellular extracts with in vitro translated cyclin D1 led to cyclin degradation.	Tretinoin	14-16	cyclin D1	Homo sapiens	88-97
11795432-10	2001	This degradation depended on the PEST domain of cyclin D1, implicating ubiquitination in this retinoid degradation.	Retinoids	94-102	cyclin D1	Homo sapiens	48-57
11751523-6	2001	In cells treated with EGCG, there was a decrease in the cyclin D1 protein, an increase in the p21(Cip1) and p27(Kip1) proteins, and a reduction in the hyperphosphorylated form of pRB, changes that may account for the arrest in G(1).	epigallocatechin gallate	22-26	cyclin D1	Homo sapiens	56-65
11751523-8	2001	Treatment with EGCG inhibited phosphorylation of the EGFR, signal transducer and activator of transcription3 (Stat3), and extracellular regulated kinase (ERK) proteins and also inhibited basal and transforming growth factor-alpha-stimulated c-fos and cyclin D1 promoter activity.	epigallocatechin gallate	15-19	cyclin D1	Homo sapiens	251-260
11739801-10	2001	Using a series of cyclin D1 promoter mutants in luciferase assays as well as electrophoretic mobility shift assays (EMSA), we showed that the EtsB binding site mediated cyclin D1 promoter regulation by FAK.	etsb	142-146	cyclin D1	Homo sapiens	18-27
11719282-7	2001	Treatment of cells with 10 nM 16alpha-OHE(1) resulted in 4- and 3-fold increases in cyclin D1 and cyclin A, respectively, at the protein level.	16-hydroxyestrone	30-41	cyclin D1	Homo sapiens	84-93
11739801-10	2001	Using a series of cyclin D1 promoter mutants in luciferase assays as well as electrophoretic mobility shift assays (EMSA), we showed that the EtsB binding site mediated cyclin D1 promoter regulation by FAK.	etsb	142-146	cyclin D1	Homo sapiens	169-178
11581254-4	2001	However, we now show that some E(2)-induced cyclin E.Cdk2 activation occurs in the absence of increased cyclin D1 levels and requires decreased p21 protein synthesis.	Estradiol	31-35	cyclin D1	Homo sapiens	104-113
11581254-7	2001	Cyclin E.Cdk2 activation is completely inhibited by a combination of antisense cyclin D1 oligonucleotide transfection and elimination of the decrease in nascent p21 by infection with adenoviral-p21.	Oligonucleotides	89-104	cyclin D1	Homo sapiens	79-88
11679177-0	2001	Decrease of cyclin D1 in the human lung adenocarcinoma cell line A-427 by 7-hydroxycoumarin.	7-hydroxycoumarin	74-91	cyclin D1	Homo sapiens	12-21
11551901-3	2001	This conclusion is based on observations indicating that cyclin D1 induction by transforming Ha-Ras was depressed in a dose-dependent manner by PD98059, a selective inhibitor of the mitogen-activated kinase kinase MEK-1, demonstrating that Ha-Ras employs extracellular signal-regulated kinases (ERKs) for signal transmission to the cyclin D1 promoter.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	144-151	cyclin D1	Homo sapiens	57-66
11551901-3	2001	This conclusion is based on observations indicating that cyclin D1 induction by transforming Ha-Ras was depressed in a dose-dependent manner by PD98059, a selective inhibitor of the mitogen-activated kinase kinase MEK-1, demonstrating that Ha-Ras employs extracellular signal-regulated kinases (ERKs) for signal transmission to the cyclin D1 promoter.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	144-151	cyclin D1	Homo sapiens	332-341
11676482-3	2001	Earlier, we have shown that resveratrol treatment results in an induction of the cyclin kinase inhibitor WAF1/CIP1/p21 which, by inhibiting cyclin (E, D1, and D2) and cyclin-dependent kinases (cdk2, cdk4, and cdk6), results in a G0/G1-phase arrest followed by apoptosis of A431 human epidermoid carcinoma cells (Ahmad et al., Clin.	Resveratrol	28-39	cyclin D1	Homo sapiens	140-161
11689445-1	2001	The p85-associated phosphatidylinositol (PI) 3-kinase/Akt pathway mediates the oestradiol-induced S-phase entry and cyclin D1 promoter activity in MCF-7 cells.	Phosphatidylinositols	19-39	cyclin D1	Homo sapiens	116-125
11689445-1	2001	The p85-associated phosphatidylinositol (PI) 3-kinase/Akt pathway mediates the oestradiol-induced S-phase entry and cyclin D1 promoter activity in MCF-7 cells.	Estradiol	79-89	cyclin D1	Homo sapiens	116-125
11689445-2	2001	Experiments with Src, p85alpha and Akt dominant-negative forms indicate that in oestradiol-treated cells these signalling effectors target the cyclin D1 promoter.	Estradiol	80-90	cyclin D1	Homo sapiens	143-152
11679177-12	2001	In contrast, cyclin D1 significantly decreased, which appears to indicate an action of 7-hydroxycoumarin in early events of phase G(1).	7-hydroxycoumarin	87-104	cyclin D1	Homo sapiens	13-22
11679177-17	2001	Knowledge of the decrease of cyclin D1 by 7-hydroxycoumarin may lead to its use in cancer therapy, as well as to the development of more active compounds.	7-hydroxycoumarin	42-59	cyclin D1	Homo sapiens	29-38
11676861-0	2001	Cyclin D1 antisense oligonucleotide inhibits cell growth stimulated by epidermal growth factor and induces apoptosis of gastric cancer cells.	Oligonucleotides	20-35	cyclin D1	Homo sapiens	0-9
11477082-0	2001	Expression of p21Waf1/Cip1 and cyclin D1 is increased in butyrate-resistant HeLa cells.	Butyrates	57-65	cyclin D1	Homo sapiens	31-40
11477082-6	2001	However, cyclin D1 was down-regulated by butyrate in HeLa cells but not in clone 5.1.	Butyrates	41-49	cyclin D1	Homo sapiens	9-18
11477082-7	2001	We conclude that continued expression of cyclin D1 allowed clone 5.1 to grow in the presence of butyrate and elevated levels of p21Waf1/Cip1.	Butyrates	96-104	cyclin D1	Homo sapiens	41-50
11601138-2	2001	Cyclin D1 expression was evaluated by immunohistochemical analysis and biotin-labeled in situ hybridization (ISH) in a series of 71 decalcified, paraffin-embedded bone marrow biopsy specimens from patients with multiple myeloma (MM).	Biotin	71-77	cyclin D1	Homo sapiens	0-9
11601138-2	2001	Cyclin D1 expression was evaluated by immunohistochemical analysis and biotin-labeled in situ hybridization (ISH) in a series of 71 decalcified, paraffin-embedded bone marrow biopsy specimens from patients with multiple myeloma (MM).	Paraffin	145-153	cyclin D1	Homo sapiens	0-9
11601138-6	2001	Our findings demonstrate the following: (1) ISH for cyclin D1 mRNA is a sensitive method for the evaluation of cyclin D1 overexpression in paraffin-embedded bone marrow biopsy specimens with MM.	Paraffin	139-147	cyclin D1	Homo sapiens	52-61
11601138-6	2001	Our findings demonstrate the following: (1) ISH for cyclin D1 mRNA is a sensitive method for the evaluation of cyclin D1 overexpression in paraffin-embedded bone marrow biopsy specimens with MM.	Paraffin	139-147	cyclin D1	Homo sapiens	111-120
11566495-1	2001	Amplification of CCND1 was studied in 23 tongue carcinoma patients by fluorescence in situ hybridization (FISH) using a paraffin embedded specimen.	Paraffin	120-128	cyclin D1	Homo sapiens	17-22
11495916-6	2001	The GSK-3 beta inhibitor lithium did not alter heat shock-induced nuclear accumulation of GSK-3 beta but increased the nuclear level of cyclin D1, indicating that cyclin D1 is a substrate of nuclear GSK-3 beta.	Lithium	25-32	cyclin D1	Homo sapiens	136-145
11495916-6	2001	The GSK-3 beta inhibitor lithium did not alter heat shock-induced nuclear accumulation of GSK-3 beta but increased the nuclear level of cyclin D1, indicating that cyclin D1 is a substrate of nuclear GSK-3 beta.	Lithium	25-32	cyclin D1	Homo sapiens	163-172
11562439-0	2001	GL331 induces down-regulation of cyclin D1 expression via enhanced proteolysis and repressed transcription.	GL 331	0-5	cyclin D1	Homo sapiens	33-42
11562439-3	2001	We found that GL331 had no inhibitory effect on the expression of cyclins E, A, B1, CDK 4, and CDK 2; instead, its cell growth-inhibitory effect was partly attributable to an early down-regulation of cyclin D1 expression and in turn the reduction of retinoblastoma protein phosphorylation.	GL 331	14-19	cyclin D1	Homo sapiens	200-209
11562439-4	2001	GL331 enhanced the proteolysis of cyclin D1, and a proteasome inhibitor was able to block GL331-caused cyclin D1 reduction, suggesting that GL331-stimulated cyclin D1 degradation was through proteasomal processes.	GL 331	0-5	cyclin D1	Homo sapiens	34-43
11676861-3	2001	In this study, we attempted to examine the therapeutic effect of cyclin D1 antisense oligonucleotides (AS/D1) on cell proliferation and apoptosis of the gastric cancer cell line MKN-74, in the presence and absence of EGF-stimulation.	Oligonucleotides	85-101	cyclin D1	Homo sapiens	65-74
11562439-4	2001	GL331 enhanced the proteolysis of cyclin D1, and a proteasome inhibitor was able to block GL331-caused cyclin D1 reduction, suggesting that GL331-stimulated cyclin D1 degradation was through proteasomal processes.	GL 331	90-95	cyclin D1	Homo sapiens	34-43
11562439-4	2001	GL331 enhanced the proteolysis of cyclin D1, and a proteasome inhibitor was able to block GL331-caused cyclin D1 reduction, suggesting that GL331-stimulated cyclin D1 degradation was through proteasomal processes.	GL 331	90-95	cyclin D1	Homo sapiens	103-112
11676861-3	2001	In this study, we attempted to examine the therapeutic effect of cyclin D1 antisense oligonucleotides (AS/D1) on cell proliferation and apoptosis of the gastric cancer cell line MKN-74, in the presence and absence of EGF-stimulation.	mkn-74	178-184	cyclin D1	Homo sapiens	65-74
11562439-4	2001	GL331 enhanced the proteolysis of cyclin D1, and a proteasome inhibitor was able to block GL331-caused cyclin D1 reduction, suggesting that GL331-stimulated cyclin D1 degradation was through proteasomal processes.	GL 331	90-95	cyclin D1	Homo sapiens	103-112
11562439-4	2001	GL331 enhanced the proteolysis of cyclin D1, and a proteasome inhibitor was able to block GL331-caused cyclin D1 reduction, suggesting that GL331-stimulated cyclin D1 degradation was through proteasomal processes.	GL 331	90-95	cyclin D1	Homo sapiens	34-43
11562439-4	2001	GL331 enhanced the proteolysis of cyclin D1, and a proteasome inhibitor was able to block GL331-caused cyclin D1 reduction, suggesting that GL331-stimulated cyclin D1 degradation was through proteasomal processes.	GL 331	90-95	cyclin D1	Homo sapiens	103-112
11562439-4	2001	GL331 enhanced the proteolysis of cyclin D1, and a proteasome inhibitor was able to block GL331-caused cyclin D1 reduction, suggesting that GL331-stimulated cyclin D1 degradation was through proteasomal processes.	GL 331	90-95	cyclin D1	Homo sapiens	103-112
11552984-5	2001	In addition, artificial silencing using antisense oligonucleotides for cyclin D1 suppressed the growth rate of some but not all cyclin D1-overexpressing cells.	Oligonucleotides	50-66	cyclin D1	Homo sapiens	71-80
11562439-8	2001	On the other hand, we found that GL331 specifically inhibited the cyclin D1 promoter-driven luciferase reporter activity.	GL 331	33-38	cyclin D1	Homo sapiens	66-75
11562439-10	2001	Furthermore, GL331"s inhibition of cyclin D1 promoter was attenuated by ectopic Erk-2 overexpression.	GL 331	13-18	cyclin D1	Homo sapiens	35-44
11562439-11	2001	These data suggested that GL331 inhibited cyclin D1 gene transcription via the Erk signaling pathway.	GL 331	26-31	cyclin D1	Homo sapiens	42-51
11562439-12	2001	In summary, we report that GL331 induced an early decline of cyclin D1 expression by dual mechanisms: 1) enhancement of protein turnover and 2) repression of Erk-mediated gene transcription.	GL 331	27-32	cyclin D1	Homo sapiens	61-70
11557736-6	2001	Furthermore, blocking p70 S6 kinase phosphorylation with rapamycin inhibited cyclin D1 expression and proliferation, suggesting that activation of p70 S6 kinase is critical in EDG-1/G(i)-mediated cell proliferation.	Sirolimus	57-66	cyclin D1	Homo sapiens	77-86
11522626-5	2001	Furthermore, these steroids were able to induce activation of the human CCND1 gene promoter, accumulation of cyclin D1 and pRb phosphorylation, all key events in cell cycle stimulation by mitogens, even in the presence of Erk1/2 activation blockade by a MAP kinase-activating kinase (Mek)1/2 inhibitor.	Steroids	19-27	cyclin D1	Homo sapiens	72-77
11522626-5	2001	Furthermore, these steroids were able to induce activation of the human CCND1 gene promoter, accumulation of cyclin D1 and pRb phosphorylation, all key events in cell cycle stimulation by mitogens, even in the presence of Erk1/2 activation blockade by a MAP kinase-activating kinase (Mek)1/2 inhibitor.	Steroids	19-27	cyclin D1	Homo sapiens	109-118
12536724-2	2001	METHODS: SP immunohistochemical technique was used to detect the expressions of of p-MAPK, cyclin D1 and p53 protein among the 58 osteosarcomas and 14 osteoid osteomas samples.	TFF2 protein, human	9-11	cyclin D1	Homo sapiens	91-100
11477579-7	2001	Our experiments with MCF-7-D1 cells indicated that PA and 4-CPA inhibited basal and estrogen-induced reporter gene activity by up to 90%, resulting in almost complete elimination of estrogen-dependent cyclin D1 gene activation.	phenylacetic acid	51-53	cyclin D1	Homo sapiens	201-210
11477579-7	2001	Our experiments with MCF-7-D1 cells indicated that PA and 4-CPA inhibited basal and estrogen-induced reporter gene activity by up to 90%, resulting in almost complete elimination of estrogen-dependent cyclin D1 gene activation.	4-chlorophenylacetic acid	58-63	cyclin D1	Homo sapiens	201-210
11470749-13	2001	In the stratification analysis the CCND1 AA variant genotype was associated with a &gt;3-fold increased risk in individuals who were &lt;/=50 years old (OR 3.18, 95% CI 1.19-8.46), females (3.57, 1.26-10.0), non-smokers (3.71, 1.37-10.1) and non-alcohol users (4.76, 1.61-14.0).	Alcohols	246-253	cyclin D1	Homo sapiens	35-40
11410592-1	2001	Cyclin D1 gene expression is induced by 17beta-estradiol (E2) in human breast cancer cells and is important for progression of cells through the G(1) phase of the cell cycle.	Estradiol	40-56	cyclin D1	Homo sapiens	0-9
11410592-3	2001	Transcriptional activation of cyclin D1 by E2 was dependent, in part, on a proximal cAMP-response element at -66, and this was linked to induction of protein kinase A-dependent pathways.	Cyclic AMP	84-88	cyclin D1	Homo sapiens	30-39
11478908-1	2001	We studied the formation of triplex DNA in the purine-pyrimidine-rich promoter site sequence of cyclin D1, located at -116 to -99 from the transcription initiation site, with a molecular beacon comprised of a G-rich 18-mer triplex forming oligodeoxyribonucleotide.	purine	47-53	cyclin D1	Homo sapiens	96-105
11478908-1	2001	We studied the formation of triplex DNA in the purine-pyrimidine-rich promoter site sequence of cyclin D1, located at -116 to -99 from the transcription initiation site, with a molecular beacon comprised of a G-rich 18-mer triplex forming oligodeoxyribonucleotide.	pyrimidine	54-64	cyclin D1	Homo sapiens	96-105
11478908-1	2001	We studied the formation of triplex DNA in the purine-pyrimidine-rich promoter site sequence of cyclin D1, located at -116 to -99 from the transcription initiation site, with a molecular beacon comprised of a G-rich 18-mer triplex forming oligodeoxyribonucleotide.	Oligodeoxyribonucleotides	239-263	cyclin D1	Homo sapiens	96-105
11481417-0	2001	Downregulation of the cyclin D1/Cdk4 complex occurs during resveratrol-induced cell cycle arrest in colon cancer cell lines.	Resveratrol	59-70	cyclin D1	Homo sapiens	22-31
11423993-8	2001	Lycopene caused a decrease in cyclin D1 and D3 levels whereas cyclin E levels did not change.	Lycopene	0-8	cyclin D1	Homo sapiens	30-39
11463860-5	2001	Time course immunochemical and biochemical analyses of the cellular and molecular effects of 1alpha,25-dihydroxyvitamin D(3) treatment for up to 6 d revealed a dynamic chain of events, preventing activation of cyclin D1/cdk4, and loss of cyclin D3, which collectively lead to repression of the E2F transcription factors and thus negatively affected cyclin A protein expression.	25-dihydroxyvitamin d	100-121	cyclin D1	Homo sapiens	210-219
11481496-7	2001	Inhibition of DNA synthesis by RA is significantly more rapid in SH-F than in SH-N. SH-F, which expresses basal amounts of p16(INK4A), responds to RA with elevation of p18(INK4C), marked down-regulation of cyclin D1, and swift inhibition of cyclin D-dependent kinases (cdks).	Tretinoin	31-33	cyclin D1	Homo sapiens	206-215
11391617-4	2001	One mM NaBt resulted in G1 cell cycle arrest, accompanied by up-regulation of p21 (waf1/cip1) and down-regulation of cyclin D1 in KoTCC-1/C cells, whereas KoTCC-1/BH showed resistance to G1 cell cycle arrest.	NABT	7-11	cyclin D1	Homo sapiens	117-126
11406180-7	2001	In addition, long-term, low dose (but not short-term, high dose) exposure to arsenite resulted in increased expression of cyclin D1.	arsenite	77-85	cyclin D1	Homo sapiens	122-131
11429697-0	2001	Ectopic expression of cyclin D1 amplifies a retinoic acid-induced mitochondrial death pathway in breast cancer cells.	Tretinoin	44-57	cyclin D1	Homo sapiens	22-31
11429697-1	2001	All-trans retinoic acid inhibits growth associated with downregulation of cyclin D1 and can cause low level apoptosis in estrogen receptor positive breast cancer cell lines.	Tretinoin	10-23	cyclin D1	Homo sapiens	74-83
11429697-3	2001	Constitutive expression of cyclin D1 in estrogen receptor positive MCF-7 and ZR-75 breast cancer cells (MCF-7(cycD1) and ZR-75(cycD1)) Increased the fraction of cells in S phase and reduced the G1 accumulation following retinoic acid treatment compared with control cells.	Tretinoin	220-233	cyclin D1	Homo sapiens	27-36
11429697-9	2001	Accordingly, coexpression of Bcl-2 and cyclin D1 rendered the cells resistant to retinoic acid-induced apoptosis.	Tretinoin	81-94	cyclin D1	Homo sapiens	39-48
11429697-10	2001	We conclude that constitutive expression of cyclin D1 sensitizes ER-positive breast cancer cells to a retinoic acid-induced mitochondrial death pathway involving Bax activation, cytochrome c release and caspase-9 cleavage.	Tretinoin	102-115	cyclin D1	Homo sapiens	44-53
11337496-5	2001	Treatment with estradiol alone resulted in a greater increase in cyclin D1 gene expression but markedly decreased p21 expression, with a concurrent increase in Cdk4 and Cdk2 activity and subsequent synchronous entry of cells into S phase.	Estradiol	15-24	cyclin D1	Homo sapiens	65-74
11408350-5	2001	In addition, incubation with mevastatin arrested cells in the G1 phase of the cell cycle after 24 h with a switch to the G2/M phase after 72 h. This was accompanied by a down-regulation of cyclin-dependent kinases (cdk) 4 and cdk 6 as well as cyclin D1, while cdk 2 and cyclin E protein levels remained unchanged during mevastatin treatment.	mevastatin	29-39	cyclin D1	Homo sapiens	243-252
11290527-5	2001	In addition, U-0126 inhibited mitogen-induced activation of p90 ribosomal S6 kinase and expression of c-Fos and cyclin D1, all of which are downstream from ERK in the signaling cascade that leads to cell proliferation.	U 0126	13-19	cyclin D1	Homo sapiens	112-121
11497244-3	2001	Sustained expression of cyclin D1 and D2 was observed when Her14 fibroblasts were incubated with 3 mM or higher H2O2 concentrations.	Hydrogen Peroxide	112-116	cyclin D1	Homo sapiens	24-40
11497244-5	2001	However, the sustained expression of cyclin D1 and D2 upon H2O2 treatment was not due to the MAP kinase pathway, because MAP kinase kinase inhibitors did not inhibit cyclin D expression.	Hydrogen Peroxide	59-63	cyclin D1	Homo sapiens	37-46
11497244-7	2001	These results indicate that H2O2 reversibly inhibits the ubiquitin-proteasome dependent degradation of cyclin D1 and D2, probably by transiently inhibiting ubiquitination and/or the proteasome.	Hydrogen Peroxide	28-32	cyclin D1	Homo sapiens	103-112
11395571-5	2001	Meanwhile, pre-treatment of cells with lactacystin, a proteasome inhibitor, abolished the RA-VII-induced decrease in cyclin D1.	lactacystin	39-50	cyclin D1	Homo sapiens	117-126
11395571-6	2001	Moreover, RA-VII still decreased cyclin D1 protein in the presence of cycloheximide.	Cycloheximide	70-83	cyclin D1	Homo sapiens	33-42
11376126-5	2001	Oestradiol can also potentiate the effect of IGF-1 on the expression of cyclin D1 and cyclin E, and on the phosphorylation of the retinoblastoma protein (RB).	Estradiol	0-10	cyclin D1	Homo sapiens	72-81
11510695-10	2001	Gossypol appears to affect the expression of Rb protein and cyclin D1 in breast cancer metastases at doses achievable, yet had negligible antitumor activity against anthracycline and taxane refractory metastatic breast cancer.	Gossypol	0-8	cyclin D1	Homo sapiens	60-69
11348869-5	2001	TTNPB, atRA, and AGN4204 inhibited the mitogenic induction of cyclin D1, whereas 9cRA had no effect.	TTNPB	0-5	cyclin D1	Homo sapiens	62-71
11348869-5	2001	TTNPB, atRA, and AGN4204 inhibited the mitogenic induction of cyclin D1, whereas 9cRA had no effect.	Tretinoin	7-11	cyclin D1	Homo sapiens	62-71
11348869-5	2001	TTNPB, atRA, and AGN4204 inhibited the mitogenic induction of cyclin D1, whereas 9cRA had no effect.	agn4204	17-24	cyclin D1	Homo sapiens	62-71
11342573-5	2001	Thus, this animal model of human primary hyperparathyroidism provides direct experimental evidence that overexpression of the cyclin D1 oncogene can drive excessive parathyroid cell proliferation and that this proliferative defect need not occur solely as a downstream consequence of a defect in parathyroid hormone secretory control by serum calcium, as had been hypothesized.	Calcium	343-350	cyclin D1	Homo sapiens	126-135
11518463-4	2001	It is not known at present whether constitutively high intracellular levels of cyclin D1 might interfere with the cytostatic actions of mevalonate/protein prenylation inhibitors.	Mevalonic Acid	136-146	cyclin D1	Homo sapiens	79-88
11518463-5	2001	This possibility was investigated here by assessing the cell cycle effects of Simvastatin, a non-toxic upstream inhibitor of the mevalonate pathway, on human BC MCF-7 cells expressing either normal or enhanced levels of cyclin D1 from of a stably transfected, tet-inducible expression vector.	Simvastatin	78-89	cyclin D1	Homo sapiens	220-229
11518463-7	2001	In addition, D1-overexpressing embryo fibroblasts were also found to be responsive to the cell cycle effects of mevalonate/protein prenylation pathway blockade, further suggesting that high intracellular levels of cyclin D1 do not prevent the cytostatic actions of compounds targeting this metabolic pathway.	Mevalonic Acid	112-122	cyclin D1	Homo sapiens	214-223
11350919-5	2001	The immunoblot analysis revealed that resveratrol treatment causes a dose- and time-dependent (a) induction of WAF1/p21; (b) decrease in the protein expressions of cyclin D1, cyclin D2, and cyclin E; and (c) decrease in the protein expressions of cdk2, cdk4, and cdk6.	Resveratrol	38-49	cyclin D1	Homo sapiens	164-173
11350919-7	2001	Taken together, our study suggests that resveratrol treatment of the cells causes an induction of WAF1/p21 that inhibits cyclin D1/D2-cdk6, cyclin D1/D2-cdk4, and cyclin E-cdk2 complexes, thereby imposing an artificial checkpoint at the G(1)--&gt;S transition of the cell cycle.	Resveratrol	40-51	cyclin D1	Homo sapiens	121-130
11350919-7	2001	Taken together, our study suggests that resveratrol treatment of the cells causes an induction of WAF1/p21 that inhibits cyclin D1/D2-cdk6, cyclin D1/D2-cdk4, and cyclin E-cdk2 complexes, thereby imposing an artificial checkpoint at the G(1)--&gt;S transition of the cell cycle.	Resveratrol	40-51	cyclin D1	Homo sapiens	140-149
11287611-6	2001	Herein PPARgamma, liganded by either natural (15d-PGJ(2) and PGD(2)) or synthetic ligands (BRL49653 and troglitazone), selectively inhibited expression of the cyclin D1 gene.	Troglitazone	104-116	cyclin D1	Homo sapiens	159-168
11287611-7	2001	The inhibition of S-phase entry and activity of the cyclin D1-dependent serine-threonine kinase (Cdk) by 15d-PGJ(2) was not observed in PPARgamma-deficient cells.	15d-pgj	105-112	cyclin D1	Homo sapiens	52-61
11287611-8	2001	Cyclin D1 overexpression reversed the S-phase inhibition by 15d-PGJ(2).	15d-pgj	60-67	cyclin D1	Homo sapiens	0-9
11287611-9	2001	Cyclin D1 repression was independent of IKK, as prostaglandins (PGs) which bound PPARgamma but lacked the IKK interactive cyclopentone ring carbonyl group repressed cyclin D1.	Prostaglandins	48-62	cyclin D1	Homo sapiens	0-9
11287611-9	2001	Cyclin D1 repression was independent of IKK, as prostaglandins (PGs) which bound PPARgamma but lacked the IKK interactive cyclopentone ring carbonyl group repressed cyclin D1.	Prostaglandins	48-62	cyclin D1	Homo sapiens	165-174
11287611-9	2001	Cyclin D1 repression was independent of IKK, as prostaglandins (PGs) which bound PPARgamma but lacked the IKK interactive cyclopentone ring carbonyl group repressed cyclin D1.	Prostaglandins	64-67	cyclin D1	Homo sapiens	165-174
11287611-9	2001	Cyclin D1 repression was independent of IKK, as prostaglandins (PGs) which bound PPARgamma but lacked the IKK interactive cyclopentone ring carbonyl group repressed cyclin D1.	cyclopentone	122-134	cyclin D1	Homo sapiens	0-9
11260626-11	2001	Bcl-1 (performed in 5 cases) was not detected in the 4 cases of blastic CD5+, CD23- B-cell lymphoma analyzed and was detected in the case of the prolymphocytoid MCL.	prolymphocytoid	145-160	cyclin D1	Homo sapiens	0-5
11264255-7	2001	Addition of PCA-4230 to cultured VSMCs blocked the induction of cyclin D1 and cyclin A expression normally seen in serum-restimulated cells.	vsmcs	33-38	cyclin D1	Homo sapiens	64-73
11341512-3	2001	PD98059, an inhibitor of MEK-1 blocked the mitogenic activity of HDL and cyclin D1 expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	cyclin D1	Homo sapiens	73-82
11315260-5	2001	METHOD: Immunohistochemical analysis of cyclin D1 expression was carried out in paraffin-embedded sections of surgically resected esophageal squamous cell carcinomas (ESCC) (70 patients) and matched with histopathologically normal esophageal tissues from a distant site.	Paraffin	80-88	cyclin D1	Homo sapiens	40-49
11230180-8	2001	Furthermore, PD980059 treatment led to the downregulation of cyclin D1 and the suppression of cell cycle progression.	pd980059	13-21	cyclin D1	Homo sapiens	61-70
11114297-4	2001	One site displays homology to a preferential D-type cyclin-dependent kinase site (serine 780) on the retinoblastoma susceptibility gene product (pRB) and, consistent with this homology, is more efficiently phosphorylated by cyclin D1-CDK4 than by the other cyclin-dependent kinases (CDK) that were tested.	Serine	82-88	cyclin D1	Homo sapiens	224-233
11243864-0	2001	Reduction in cyclin D1/Cdk4/retinoblastoma protein signaling by CRE-decoy oligonucleotide.	Oligonucleotides	74-89	cyclin D1	Homo sapiens	13-22
11267961-11	2001	In addition, U0126, which is a potent inhibitor for ERK phosphorylation, antagonized increase of cyclin D1, thus suggesting that EGF- or HGF-mediated ERK phosphorylation might have played an essential role for cell growth.	U 0126	13-18	cyclin D1	Homo sapiens	97-106
11248121-0	2001	Nitric oxide-induced cytostasis and cell cycle arrest of a human breast cancer cell line (MDA-MB-231): potential role of cyclin D1.	Nitric Oxide	0-12	cyclin D1	Homo sapiens	121-130
11248121-4	2001	This NO-induced cytostasis and decrease in cyclin D1 was reversible for up to 48 h of DETA-NONOate (1 mM) treatment.	2,2'-(hydroxynitrosohydrazono)bis-ethanamine	86-98	cyclin D1	Homo sapiens	43-52
11248121-11	2001	We conclude that down-regulation of cyclin D1 protein by DETA-NONOate played an important role in the cytostasis and arrest of these tumor cells in the G(1) phase of the cell cycle.	2,2'-(hydroxynitrosohydrazono)bis-ethanamine	57-69	cyclin D1	Homo sapiens	36-45
11243864-9	2001	These data suggest that inhibition of cyclin D1 expression contributes to the growth inhibition induced by the decoy oligonucleotide in MCF7 cells through a cyclin D1/Cdk4/pRB signaling pathway.	Oligonucleotides	117-132	cyclin D1	Homo sapiens	38-47
11243864-9	2001	These data suggest that inhibition of cyclin D1 expression contributes to the growth inhibition induced by the decoy oligonucleotide in MCF7 cells through a cyclin D1/Cdk4/pRB signaling pathway.	Oligonucleotides	117-132	cyclin D1	Homo sapiens	157-166
11238488-6	2001	Stimulation of benign and malignant thyroid cells with 17beta-estradiol resulted in an increased proliferation rate and an enhanced expression of cyclin D1 protein, which plays a key role in the regulation of G(1)/S transition in the cell cycle.	Estradiol	55-71	cyclin D1	Homo sapiens	146-155
11267976-1	2001	To elucidate the mechanism of action of sodium butyrate (NaB), we examined its effect on the expression of some cell cycle-related proteins (cyclins D1 and E, p16(ink4), p21(waf1), p27(kip1)) in 2 human non-small cell lung cancer cell lines (NCI-460 and NCI-H23) characterized by wild- type and mutant TP53, respectively.	Butyric Acid	40-55	cyclin D1	Homo sapiens	141-157
11267976-1	2001	To elucidate the mechanism of action of sodium butyrate (NaB), we examined its effect on the expression of some cell cycle-related proteins (cyclins D1 and E, p16(ink4), p21(waf1), p27(kip1)) in 2 human non-small cell lung cancer cell lines (NCI-460 and NCI-H23) characterized by wild- type and mutant TP53, respectively.	nab	57-60	cyclin D1	Homo sapiens	141-157
11238488-11	2001	Treatment of the cells with 17beta-estradiol and MAP kinase kinase 1 inhibitor, PD 098059, prevented the accumulation of cyclin D1 and estrogen-mediated mitogenesis.	Estradiol	28-44	cyclin D1	Homo sapiens	121-130
11160381-0	2001	Schwann cell proliferative responses to cAMP and Nf1 are mediated by cyclin D1.	Cyclic AMP	40-44	cyclin D1	Homo sapiens	69-78
11160381-7	2001	Ectopic expression studies using an inducible retroviral vector show that the G(1) phase requirement for cAMP can be alleviated by a single protein, cyclin D1.	Cyclic AMP	105-109	cyclin D1	Homo sapiens	149-158
11160381-9	2001	Thus a G(1) phase-specific protein, cyclin D1, accounts for two salient features of Schwann cell growth control: the promitotic response to cAMP and the antimitotic response to the Nf1 tumor suppressor.	Cyclic AMP	140-144	cyclin D1	Homo sapiens	36-45
11024050-0	2001	Transcriptional activation of the cyclin D1 gene is mediated by multiple cis-elements, including SP1 sites and a cAMP-responsive element in vascular endothelial cells.	Cyclic AMP	113-117	cyclin D1	Homo sapiens	34-43
11245482-7	2001	Geldanamycin also decreased the nuclear beta-catenin level and inhibited beta-catenin-driven transcription, as assessed using two different beta-catenin-sensitive reporters and the endogenous cyclin D1 gene.	geldanamycin	0-12	cyclin D1	Homo sapiens	192-201
11235907-0	2001	In situ hybridization and reverse transcription-polymerase chain reaction for cyclin D1 mRNA in the diagnosis of mantle cell lymphoma in paraffin-embedded tissues.	Paraffin	137-145	cyclin D1	Homo sapiens	78-87
11235907-11	2001	In conclusion, stringent RT-PCR for cyclin D1 expression can be helpful in MCL diagnosis in paraffin-embedded material from lymph nodes.	Paraffin	92-100	cyclin D1	Homo sapiens	36-45
11160886-4	2001	We have used a novel DNA-binding ligand, GL020924, to target the site at -30 (-30-21) of the cyclin D1 promoter in MCF7 breast cancer cells.	GL020924	41-49	cyclin D1	Homo sapiens	93-102
11160886-6	2001	Treatment with GL020924 specifically inhibited expression of the targeted cyclin D1 promoter construct in MCF7 cells in a concentration-dependent manner, thus validating the -30-21 site as a target for minor groove-binding ligands.	GL020924	15-23	cyclin D1	Homo sapiens	74-83
11170137-8	2001	In other studies, silymarin, genistein or EGCG caused a strong induction of Cip1/p21 (up to 2.4-fold) and Kip1/p27 (up to 150-fold), and a strong decrease in CDK4 (40-90%) but had moderate effect on CDK2, and cyclins D1 and E.	Silymarin	18-27	cyclin D1	Homo sapiens	209-225
11170137-8	2001	In other studies, silymarin, genistein or EGCG caused a strong induction of Cip1/p21 (up to 2.4-fold) and Kip1/p27 (up to 150-fold), and a strong decrease in CDK4 (40-90%) but had moderate effect on CDK2, and cyclins D1 and E.	Genistein	29-38	cyclin D1	Homo sapiens	209-225
11170137-8	2001	In other studies, silymarin, genistein or EGCG caused a strong induction of Cip1/p21 (up to 2.4-fold) and Kip1/p27 (up to 150-fold), and a strong decrease in CDK4 (40-90%) but had moderate effect on CDK2, and cyclins D1 and E.	epigallocatechin gallate	42-46	cyclin D1	Homo sapiens	209-225
11159766-3	2001	METHODS: A quantitative real-time reverse transcription (RT)-PCR assay was developed for cyclin D1 mRNA suitable for use with RNA extracted from fresh and formalin-fixed, paraffin-embedded tissues.	Formaldehyde	155-163	cyclin D1	Homo sapiens	89-98
11159766-3	2001	METHODS: A quantitative real-time reverse transcription (RT)-PCR assay was developed for cyclin D1 mRNA suitable for use with RNA extracted from fresh and formalin-fixed, paraffin-embedded tissues.	Paraffin	171-179	cyclin D1	Homo sapiens	89-98
11241756-5	2001	Treatment of these cells with 100 nM zearalenone induced cell-cycle transit after increases in the expression of c-myc mRNA and cyclins D1, A, and B1 and downregulation of p27(Kip-1).	Zearalenone	37-48	cyclin D1	Homo sapiens	128-149
11024050-2	2001	The results of luciferase assays showed that transcriptional activity of the cyclin D1 promoter was largely mediated by SP1 sites and a cAMP-responsive element (CRE).	Cyclic AMP	136-140	cyclin D1	Homo sapiens	77-86
11270487-3	2001	To further explore the molecular mechanisms of the antiproliferative activity in SCCHN we studied the influence of 1,25(OH)2D3 on the expression of the G1 phase-regulating proteins cyclin D1, p21 and p27.	Calcitriol	115-126	cyclin D1	Homo sapiens	181-190
12426170-2	2001	METHODS: Immunohistochemical method was used to detect the expression of CD20, CD45RO and cyclin D1 in 31 formalin- fixed and paraffin-embedded tissue samples of human small cell lymphomas.	Formaldehyde	106-114	cyclin D1	Homo sapiens	90-99
11504311-2	2001	Immunohistochemical overexpression of cyclin D1 was determined in paraffin-embedded specimens from diagnostic biopsies of 89 primary cases of squamous cell carcinoma of the head and neck (SCCHN), using a polyclonal antiserum.	Paraffin	66-74	cyclin D1	Homo sapiens	38-47
11504311-4	2001	Patients whose tumors were overexpressing cyclin D1 showed complete or partial response to neoadjuvant chemotherapy with cisplatin/5-FU.	Cisplatin	121-130	cyclin D1	Homo sapiens	42-51
11504311-4	2001	Patients whose tumors were overexpressing cyclin D1 showed complete or partial response to neoadjuvant chemotherapy with cisplatin/5-FU.	Fluorouracil	131-135	cyclin D1	Homo sapiens	42-51
11759294-4	2001	In terms of cell cycle regulators, silibinin treatment showed an induction of Cip1/p21 and Kip1/p27 together with a significant decrease in cyclin-dependent kinase (CDK)-4, CDK2, and cyclin D1.	Silybin	35-44	cyclin D1	Homo sapiens	183-192
11759294-5	2001	Quercetin treatment, however, resulted in a moderate increase in Cip1/p21 with no change in Kip1/p27 and a decrease in CDK4 and cyclin D1.	Quercetin	0-9	cyclin D1	Homo sapiens	128-137
10991938-5	2000	Recruitment of p21 to cyclin E-Cdk2 complexes was in turn dependent on decreased cyclin D1 expression since it was apparent following treatment with antisense cyclin D1 oligonucleotides.	Oligonucleotides	169-185	cyclin D1	Homo sapiens	159-168
12539585-2	2001	The expression levels of CyclinD1 and ER in the tissue samples were detected by using flow cytometry and L SAB immunohistochemistry staining, respectively.	l sab	105-110	cyclin D1	Homo sapiens	25-33
10991938-8	2000	Thus, ICI 182780 inhibits both cyclin D1-Cdk4 and cyclin E-Cdk2 activity, resulting in the arrest of MCF-7 cells in a state with characteristics of quiescence (G(0)), as opposed to G(1) arrest.	Fulvestrant	6-16	cyclin D1	Homo sapiens	31-40
10991938-5	2000	Recruitment of p21 to cyclin E-Cdk2 complexes was in turn dependent on decreased cyclin D1 expression since it was apparent following treatment with antisense cyclin D1 oligonucleotides.	Oligonucleotides	169-185	cyclin D1	Homo sapiens	81-90
10993886-0	2000	Salicylate-induced growth arrest is associated with inhibition of p70s6k and down-regulation of c-myc, cyclin D1, cyclin A, and proliferating cell nuclear antigen.	Salicylates	0-10	cyclin D1	Homo sapiens	103-112
11144927-3	2000	Cyclin D1 immunohistochemistry in fixed, paraffin-embedded tissue contributes to the precise and reproducible diagnosis of MCL without the requirement of fresh tissue.	Paraffin	41-49	cyclin D1	Homo sapiens	0-9
11078807-4	2000	Treatment of ACHN cells with 1 mM NaBt resulted in G1 cell cycle arrest, accompanied by up-regulation of p21 (waf1/cip1) and down-regulation of cyclin D1.	NABT	34-38	cyclin D1	Homo sapiens	144-153
11329937-7	2000	Cyclin D1 expression of carcinoma cells treated with NAC decreased remarkably compared with cells without NAC treatment.	Acetylcysteine	53-56	cyclin D1	Homo sapiens	0-9
11329937-7	2000	Cyclin D1 expression of carcinoma cells treated with NAC decreased remarkably compared with cells without NAC treatment.	Acetylcysteine	106-109	cyclin D1	Homo sapiens	0-9
11123423-5	2000	EGF induced cell proliferation through ERK phosphorylation, since U0126, which is an inhibitor of ERK phosphorylation, abrogated the increase of cyclin D1 by EGF.	U 0126	66-71	cyclin D1	Homo sapiens	145-154
11144927-9	2000	In summary, although the total number of studied cases is small and a larger series of cases may be required to confirm our data, we present optimized immunohistochemical conditions for cyclin D1 in fixed, paraffin-embedded tissue that can be useful in distinguishing MCL and hairy cell leukemia from other small B-cell neoplasms and reactive lymphoid infiltrates.	Paraffin	206-214	cyclin D1	Homo sapiens	186-195
11124421-4	2000	We show that nuclear localized cyclin D1, an activator of Cdk4/6, is upregulated during kainic acid evoked death of CA3/CA1 neurons and that this upregulation is associated with increased phosphorylation of a critical CDK substrate, pRb.	Kainic Acid	88-99	cyclin D1	Homo sapiens	31-40
11073968-1	2000	We report that the functional interaction between cyclin D1 and the estrogen receptor (ER) is regulated by a signal transduction pathway involving the second messenger, cyclic AMP (cAMP).	Cyclic AMP	169-179	cyclin D1	Homo sapiens	50-59
11073968-1	2000	We report that the functional interaction between cyclin D1 and the estrogen receptor (ER) is regulated by a signal transduction pathway involving the second messenger, cyclic AMP (cAMP).	Cyclic AMP	181-185	cyclin D1	Homo sapiens	50-59
11073968-2	2000	The cell-permeable cAMP analogue 8-bromo-cAMP caused a concentration-dependent enhancement of cyclin D1-ER complex formation, as judged both by coimmunoprecipitation and mammalian two-hybrid analysis.	Cyclic AMP	19-23	cyclin D1	Homo sapiens	94-103
11073968-2	2000	The cell-permeable cAMP analogue 8-bromo-cAMP caused a concentration-dependent enhancement of cyclin D1-ER complex formation, as judged both by coimmunoprecipitation and mammalian two-hybrid analysis.	8-Bromo Cyclic Adenosine Monophosphate	33-45	cyclin D1	Homo sapiens	94-103
11073968-6	2000	These findings demonstrate a collaboration between cAMP signaling and cyclin D1 in the ligand-independent activation of ER-mediated transcription in mammary epithelial cells and show that the functional associations of cyclin D1 are regulated as a function of cellular context.	Cyclic AMP	51-55	cyclin D1	Homo sapiens	219-228
10952989-2	2000	Exposition of Granta 519 cells to osmotic shock, oxidative stress, and arsenite induced the post-transcriptional down-regulation of cyclin D1.	arsenite	71-79	cyclin D1	Homo sapiens	132-141
10952989-7	2000	We found that p38(SAPK2) phosphorylates cyclin D1 in vitro at Thr(286) and that this phosphorylation triggers the ubiquitination of cyclin D1.	Threonine	62-65	cyclin D1	Homo sapiens	40-49
11106251-4	2000	Butyrate also inhibits proliferation in breast cancer cell lines and modulates expression of key cell cycle-regulatory proteins including cyclin D1.	Butyrates	0-8	cyclin D1	Homo sapiens	138-147
11106251-12	2000	The effects on cyclin D1 expression correlated with the effects on cell proliferation, which suggests that modulation of cyclin D1 expression may underpin the antiproliferative effects of butyrates.	Butyrates	188-197	cyclin D1	Homo sapiens	15-24
11106251-12	2000	The effects on cyclin D1 expression correlated with the effects on cell proliferation, which suggests that modulation of cyclin D1 expression may underpin the antiproliferative effects of butyrates.	Butyrates	188-197	cyclin D1	Homo sapiens	121-130
11126356-2	2000	Cyclin D1 also is able to associate with the amino terminus of TAFII250 in a region very similar to or overlapping the Rb-binding site.	Rubidium	119-121	cyclin D1	Homo sapiens	0-9
10938272-5	2000	Hyperacetylated histone H4 appeared within 2 h of the addition of quinidine to the medium, and levels were maximal by 24 h. Quinidine-treated MCF-7 cells showed elevated p21(WAF1), hypophosphorylation and suppression of retinoblastoma protein, and down-regulation of cyclin D1, similar to the cell cycle response observed with cells induced to differentiate by histone deacetylase inhibitors, trichostatin A, and trapoxin.	Quinidine	124-133	cyclin D1	Homo sapiens	267-276
11027261-0	2000	Down-regulation of cyclin D1 expression by prostaglandin A(2) is mediated by enhanced cyclin D1 mRNA turnover.	Prostaglandins A	43-58	cyclin D1	Homo sapiens	19-28
11027261-0	2000	Down-regulation of cyclin D1 expression by prostaglandin A(2) is mediated by enhanced cyclin D1 mRNA turnover.	Prostaglandins A	43-58	cyclin D1	Homo sapiens	86-95
11027261-1	2000	Prostaglandin A(2) (PGA(2)), an experimental chemotherapeutic agent, causes growth arrest associated with decreased cyclin D1 expression in several cancer cell lines.	prostaglandin A2	0-18	cyclin D1	Homo sapiens	116-125
11027261-1	2000	Prostaglandin A(2) (PGA(2)), an experimental chemotherapeutic agent, causes growth arrest associated with decreased cyclin D1 expression in several cancer cell lines.	prostaglandin A2	20-26	cyclin D1	Homo sapiens	116-125
11027261-2	2000	Here, using human non-small-cell lung carcinoma H1299 cells, we investigated the mechanisms whereby PGA(2) down-regulates cyclin D1 expression.	prostaglandin A2	100-106	cyclin D1	Homo sapiens	122-131
11027261-4	2000	Instead, the cyclin D1 mRNA was rendered unstable after exposure to PGA(2).	prostaglandin A2	68-74	cyclin D1	Homo sapiens	13-22
11007941-13	2000	Silymarin, genistein, and EGCG also resulted in a significant induction of Cip1/p21 and Kip1/p27 and a decrease in cyclin-dependent kinase (CDK) 4, but a moderate inhibition of CDK2, cyclin D1, and cyclin E was observed.	Silymarin	0-9	cyclin D1	Homo sapiens	183-192
10921913-5	2000	In contrast, the inhibition of cell proliferation by amlexanox correlates with the inhibition of cyclin D1 expression without interference of the receptor tyrosine kinase/mitogen-activated protein kinase signaling pathway.	amlexanox	53-62	cyclin D1	Homo sapiens	97-106
11007941-13	2000	Silymarin, genistein, and EGCG also resulted in a significant induction of Cip1/p21 and Kip1/p27 and a decrease in cyclin-dependent kinase (CDK) 4, but a moderate inhibition of CDK2, cyclin D1, and cyclin E was observed.	Genistein	11-20	cyclin D1	Homo sapiens	183-192
11007941-13	2000	Silymarin, genistein, and EGCG also resulted in a significant induction of Cip1/p21 and Kip1/p27 and a decrease in cyclin-dependent kinase (CDK) 4, but a moderate inhibition of CDK2, cyclin D1, and cyclin E was observed.	epigallocatechin gallate	26-30	cyclin D1	Homo sapiens	183-192
11110058-0	2000	Biphasic effect of medroxyprogesterone-acetate (MPA) treatment on proliferation and cyclin D1 gene transcription in T47D breast cancer cells.	Medroxyprogesterone Acetate	19-46	cyclin D1	Homo sapiens	84-93
10952788-8	2000	Thus, FR901228, while not directly inhibiting kinase activity, causes cyclin D1 downregulation and a p53-independent p21 induction, leading to inhibition of CDK and dephosphorylation of Rb resulting in growth arrest in the early G1 phase.	romidepsin	6-14	cyclin D1	Homo sapiens	70-79
11110058-7	2000	In conclusion, our results confirm the existence of a biphasic response of T47D cell proliferation in response to MPA treatment, consisting of stimulation of proliferation followed by inhibition, and further implicate cyclin D1 as a mediator of these effects, since the cyclin D1 promoter shows a similar biphasic response in this context.	Medroxyprogesterone Acetate	114-117	cyclin D1	Homo sapiens	218-227
11110058-7	2000	In conclusion, our results confirm the existence of a biphasic response of T47D cell proliferation in response to MPA treatment, consisting of stimulation of proliferation followed by inhibition, and further implicate cyclin D1 as a mediator of these effects, since the cyclin D1 promoter shows a similar biphasic response in this context.	Medroxyprogesterone Acetate	114-117	cyclin D1	Homo sapiens	270-279
10999955-5	2000	15d-PGJ(2) was found to inhibit the phosphatidylinositol 3-kinase/protein kinase B signaling pathway, which mediates cyclin D1 expression.	15d-pgj	0-7	cyclin D1	Homo sapiens	117-126
10999955-5	2000	15d-PGJ(2) was found to inhibit the phosphatidylinositol 3-kinase/protein kinase B signaling pathway, which mediates cyclin D1 expression.	Phosphatidylinositols	36-56	cyclin D1	Homo sapiens	117-126
10903423-6	2000	BMP-2 inhibited estradiol-induced cyclin D1-associated kinase activity.	Estradiol	16-25	cyclin D1	Homo sapiens	34-43
10969976-0	2000	Cinnamaldehydes inhibit cyclin dependent kinase 4/cyclin D1.	cinnamaldehyde	0-15	cyclin D1	Homo sapiens	50-59
10922227-2	2000	DESIGN: Squamous cell carcinoma of the head and neck (SCCHN) cells were stably transfected with an antisense cyclin D1 using lipofectin-mediated transfection.	1,2-dielaidoylphosphatidylethanolamine	125-135	cyclin D1	Homo sapiens	109-118
10922227-6	2000	Furthermore, antisense cyclin D1 transfection enhanced the chemosensitivity against cisplatin.	Cisplatin	84-93	cyclin D1	Homo sapiens	23-32
10922227-8	2000	Additionally, expression of cyclin D1 may make human head and neck cancer cells resistant to platinum-based chemotherapeutic approaches.	Platinum	93-101	cyclin D1	Homo sapiens	28-37
10927622-2	2000	Unexpectedly, this elevation of cyclin D1 expression by all of these agents is inhibited by the specific phosphatidylinositol 3-kinase (PI3-K) inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	153-161	cyclin D1	Homo sapiens	32-41
10927622-4	2000	Here we show that inhibition of PI3-K by LY294002 decreases the half-life of the 4.5 kb cyclin D1 mRNA species.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	cyclin D1	Homo sapiens	88-97
10964614-4	2000	In these experimental models, ceramide accumulation mediated activation and nuclear translocation of the transcription factor NFkappaB and cyclin D1 protein expression.	Ceramides	30-38	cyclin D1	Homo sapiens	139-148
10914551-7	2000	During herbimycin A treatment, both c-myc and cyclin D1 mRNA showed transient downregulation before the increase of G1 cells.	herbimycin	7-19	cyclin D1	Homo sapiens	46-55
10893323-7	2000	Immunoprecipitation with an anti-cyclin D1 antibody of cell lysates prepared from cAMP-treated cells followed by immunoblotting with antisera to p27(kip1) disclosed a threefold increase in p27(kip1) associated with cyclin D1 compared with lysates treated with serum alone.	Cyclic AMP	82-86	cyclin D1	Homo sapiens	33-42
10893323-7	2000	Immunoprecipitation with an anti-cyclin D1 antibody of cell lysates prepared from cAMP-treated cells followed by immunoblotting with antisera to p27(kip1) disclosed a threefold increase in p27(kip1) associated with cyclin D1 compared with lysates treated with serum alone.	Cyclic AMP	82-86	cyclin D1	Homo sapiens	215-224
10893323-9	2000	This occurs secondary to a suppression in cyclin D1 and induction of p27(kip1) expression, which in turn inhibits Rb phosphorylation.	Rubidium	114-116	cyclin D1	Homo sapiens	42-51
10884506-4	2000	Suramin induced HUVEC to accumulate in G1-phase as an increase of the number of cells expressing both cyclin D(1) and PCNA was observed.	Suramin	0-7	cyclin D1	Homo sapiens	102-113
10893323-4	2000	cAMP treatment blunted the serum-induced rise in cyclin D1 during cell cycle progression without altering levels of the cyclin-dependent kinase cdk4 or cyclin E and its associated kinase, cdk2.	Cyclic AMP	0-4	cyclin D1	Homo sapiens	49-58
10914551-8	2000	Herbimycin A treatment caused the downregulation of both telomerase activity and hTERT mRNA in cyclin D1-transfected K562 cells, while telomerase activity was partially restored in c-Myc-transfected cells.	herbimycin	0-12	cyclin D1	Homo sapiens	95-104
10828676-5	2000	The time course study revealed that expression of cyclin D(1), cdk2, and cdk4 was significantly (&gt;50%) downregulated in 3 h of MG (3 mM) exposure, followed by the dephosphorylation of retinoblastoma protein by 6 h. Both the glyceraldehyde-3-phosphate dehydrogenase activity and the cellular lactate level were also reduced by approximately 50 and 80%, respectively, following 6-hour MG exposure.	Lactic Acid	294-301	cyclin D1	Homo sapiens	50-61
10959623-4	2000	At inhibitory concentrations (higher than 1 mM) NaB reduced cyclin D1 and p53 level in a dose-dependent manner and sustained the synthesis of p21waf1/cip1, probably in a p53-independent way, accounting for the G0/G1 block observed by flow cytometry.	nab	48-51	cyclin D1	Homo sapiens	60-69
10766840-4	2000	Previous studies have demonstrated that cyclin D1 ubiquitination is dependent on its phosphorylation by glycogen synthase kinase 3beta (GSK-3beta) on threonine 286 and that this phosphorylation event is greatly enhanced by binding to CDK4 (Diehl, J.	Threonine	150-159	cyclin D1	Homo sapiens	40-49
11032757-3	2000	Induction of cyclin D1 antisense mRNA by the ecdysteroid, ponasterone A, resulted in a 55% decrease in cyclin D1 mRNA and a 58% decrease in CD1 protein levels.	ponasterone A	58-71	cyclin D1	Homo sapiens	13-22
11032757-3	2000	Induction of cyclin D1 antisense mRNA by the ecdysteroid, ponasterone A, resulted in a 55% decrease in cyclin D1 mRNA and a 58% decrease in CD1 protein levels.	ponasterone A	58-71	cyclin D1	Homo sapiens	103-112
10885602-4	2000	Furthermore, to evaluate the relationship between the effect of preoperative cisplatin treatment and p53 and cyclin D1 expression, we investigated p53 and cyclin D1 expression in pretreatment biopsy samples using an immunohistochemical analysis and compared the results with the histological effect to cisplatin in the resected oesophagus.	Cisplatin	77-86	cyclin D1	Homo sapiens	109-118
10716680-10	2000	Butyrate inhibited the mRNA expression of cyclin D1 without affecting its protein expression and stimulated the protein expression of cyclin D3 without affecting its mRNA expression.	Butyrates	0-8	cyclin D1	Homo sapiens	42-51
10716680-11	2000	Trichostatin A showed similar effects on cyclin D1 and D3.	trichostatin A	0-14	cyclin D1	Homo sapiens	41-50
10688905-1	2000	In this paper, we present evidence that activation of 5-hydroxytryptamine 2B (5-HT2B) receptors by serotonin (5-HT) leads to cell-cycle progression through retinoblastoma protein hyperphosphorylation and through activation of both cyclin D1/cdk4 and cyclin E/cdk2 kinases by a mechanism that depends on induction of cyclin D1 and cyclin E protein levels.	Serotonin	99-108	cyclin D1	Homo sapiens	231-240
10688905-1	2000	In this paper, we present evidence that activation of 5-hydroxytryptamine 2B (5-HT2B) receptors by serotonin (5-HT) leads to cell-cycle progression through retinoblastoma protein hyperphosphorylation and through activation of both cyclin D1/cdk4 and cyclin E/cdk2 kinases by a mechanism that depends on induction of cyclin D1 and cyclin E protein levels.	Serotonin	99-108	cyclin D1	Homo sapiens	316-325
10702262-6	2000	A transient exposure of A431 cells to AG-1478 resulted in a dose-dependent up-regulation of the cyclin-dependent kinase inhibitor p27, down-regulation of cyclin D1 and of active MAPK, and hypophosphorylation of the retinoblastoma protein (Rb).	RTKI cpd	38-45	cyclin D1	Homo sapiens	154-163
10623573-0	2000	Herbimycin A induces G1 arrest through accumulation of p27(Kip1) in cyclin D1-overexpressing fibroblasts.	herbimycin	0-12	cyclin D1	Homo sapiens	68-77
12212252-1	2000	The expressions of p42/44 mitogen-activated protein kinase(p42/p44MAPK) and cyclin D1 protein were detected by SP immunohistochemical technique in 40 cases of Hodgkin"s disease(HD) and 13 cases of reactive hyperplasia(RH).	TFF2 protein, human	111-113	cyclin D1	Homo sapiens	76-85
10937050-5	2000	The aim of this study was to evaluate and optimize a method for detection of cyclin D1 by paraffin section immunoperoxidase staining.	Paraffin	90-98	cyclin D1	Homo sapiens	77-86
10937050-14	2000	We conclude that cyclin D1 immunostaining of formalin-fixed, paraffin-embedded tissue can be reliably achieved by heat induces antigen retrieval and a cocktail of two monoclonal antibodies.	Formaldehyde	45-53	cyclin D1	Homo sapiens	17-26
10937050-14	2000	We conclude that cyclin D1 immunostaining of formalin-fixed, paraffin-embedded tissue can be reliably achieved by heat induces antigen retrieval and a cocktail of two monoclonal antibodies.	Paraffin	61-69	cyclin D1	Homo sapiens	17-26
10623573-2	2000	When quiescent Rat6 fibroblast cells were treated with herbimycin A, serum-induced expression of cyclin D1 was inhibited, and this was associated with inhibition of G1 phase progression.	herbimycin	55-67	cyclin D1	Homo sapiens	97-106
10623573-3	2000	However, herbimycin A also inhibited serum-induced G1 progression in derivatives of the Rat6 fibroblast cell line that stably overexpress a human cyclin D1 cDNA (R6ccnD1#4 cells), without affecting the expression levels of G1 cyclins.	herbimycin	9-21	cyclin D1	Homo sapiens	146-155
11525606-0	2000	Stimulatory effect of arachidonic acid on T-47D human breast cancer cell growth is associated with enhancement of cyclin D1 mRNA expression.	Arachidonic Acid	22-38	cyclin D1	Homo sapiens	114-123
10631359-10	2000	Salicylate significantly inhibited serum-induced progression from G1 to S phase, cellular proliferation, and the expression of cyclin D1.	Salicylates	0-10	cyclin D1	Homo sapiens	127-136
10752677-6	2000	In contrast, cyclin D1 overexpression significantly stimulated anchorage-independent colonization in soft agar or methylcellulose, accompanied by greater Gl-S progression.	Agar	106-110	cyclin D1	Homo sapiens	13-22
11525606-7	2000	These results suggest that arachidonic acid may exert a stimulatory effect on breast cancer cell growth and that this effect possibly involves the induction of cyclin D1 gene expression leading to cell cycle progression.	Arachidonic Acid	27-43	cyclin D1	Homo sapiens	160-169
10585260-3	1999	Cyclin D1 and D3 mRNA levels decreased during complete differentiation induced by all-trans-retinoic acid and dibutyryl cAMP, while the levels of cyclin D2 and the cyclin-dependent kinase (Cdk) inhibitor p27 mRNAs increased.	Tretinoin	82-105	cyclin D1	Homo sapiens	0-9
10585260-3	1999	Cyclin D1 and D3 mRNA levels decreased during complete differentiation induced by all-trans-retinoic acid and dibutyryl cAMP, while the levels of cyclin D2 and the cyclin-dependent kinase (Cdk) inhibitor p27 mRNAs increased.	Cyclic AMP	120-124	cyclin D1	Homo sapiens	0-9
10683762-0	1999	ERK/MAPK pathway is required for changes of cyclin D1 and B1 during phorbol 12-myristate 13-acetate-induced differentiation of K562 cells.	Tetradecanoylphorbol Acetate	68-99	cyclin D1	Homo sapiens	44-60
10683762-3	1999	The concentrations of cyclin D1 and p21Waf1/Cip1 were dramatically increased, whereas those of cyclin B1 and cdc2 were decreased, by PMA treatment.	Tetradecanoylphorbol Acetate	133-136	cyclin D1	Homo sapiens	22-31
10683762-5	1999	PD98059, a specific inhibitor of MEK1, partially prevented the increase in cyclin D1 caused by PMA and fully reversed the down-regulation of cyclin B1 protein seen in response to PMA treatment.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	cyclin D1	Homo sapiens	75-84
10683762-6	1999	Thus, it is demonstrated here that the PMA-mediated changes of cyclin D1 and B1 are the result of a persistent increase in extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) activity.	Tetradecanoylphorbol Acetate	39-42	cyclin D1	Homo sapiens	63-72
10661763-4	1999	In this model, TAM resistance resulted in an increase in the detectable basal levels of cyclin E, GADD 153, p16, BAX, Bcl-XL, and wild-type and mutant p53, an increase in TAM induction of p16, and a decrease in the detectable basal levels of cyclin D1, p21 and p27.	Tamoxifen	15-18	cyclin D1	Homo sapiens	242-251
10530763-5	1999	We found that mimosine specifically inhibited cyclin D1 expression in H226 cells.	Mimosine	14-22	cyclin D1	Homo sapiens	46-55
10597234-10	1999	Utilizing a tet-regulated gene expression system, we have shown that proliferation of stably transfected primary REFs in vitro and in vivo is dependent on the continued expression of the cyclin D1-cdk4 fusion gene.	tetramethylenedisulfotetramine	12-15	cyclin D1	Homo sapiens	187-196
10523665-6	1999	Both Dbs and Dbl activate multiple signaling pathways that include activation of the Elk-1, Jun, and NF-kappaB transcription factors and stimulation of transcription from the cyclin D1 promoter.	dibromsalan	5-8	cyclin D1	Homo sapiens	175-184
10656873-11	1999	The cell cycle alterations induced by beta-lapachone were congruous with changes in cell cycle regulatory proteins such as cyclin A, cyclin B1, cdc2, and cyclin D1.	beta-lapachone	38-52	cyclin D1	Homo sapiens	154-163
10571528-0	1999	Distinct role of cAMP and cGMP in the cell cycle control of vascular smooth muscle cells: cGMP delays cell cycle transition through suppression of cyclin D1 and cyclin-dependent kinase 4 activation.	Cyclic GMP	90-94	cyclin D1	Homo sapiens	147-156
10571528-4	1999	In contrast, cGMP inhibits cyclin D1 expression, inhibits cdk4 activation, and delays platelet-derived growth factor-mediated cdk2 activation, resulting in a delay in G(1)/S transition.	Cyclic GMP	13-17	cyclin D1	Homo sapiens	27-36
10537037-8	1999	There was little cyclin D1 in quiescent cells, but it increased during the G1 phase and was reduced by cyclic AMP.	Cyclic AMP	103-113	cyclin D1	Homo sapiens	17-26
10525058-2	1999	Western blot analysis revealed that reduction of cyclin D1 levels is a key mechanism by which the vitamin D compounds under investigation inhibit Caco-2 tumor cell growth.	Vitamin D	98-107	cyclin D1	Homo sapiens	49-58
10531416-4	1999	Inhibition of thrombin-stimulated DNA synthesis by albuterol (1-100 nM), 8-bromo-cAMP (300 microM), or prostaglandin E(2) (1 microM) was accompanied by a reduction in cyclin D1 protein levels.	Dinoprostone	103-121	cyclin D1	Homo sapiens	167-176
10531416-5	1999	The ERK kinase inhibitor PD98059 (3-30 microM) attenuated thrombin-stimulated ERK phosphorylation and activity and the increase in cyclin D1 protein levels, as did albuterol (1-100 nM) or 8-bromo-cAMP (300 microM).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	25-32	cyclin D1	Homo sapiens	131-140
10531416-7	1999	The proteasome inhibitor MG132 (30 and 100 nM) and the calpain I inhibitor N-acetyl-Leu-Leu-leucinal (10 microM) attenuated the reduction in thrombin-stimulated cyclin D1 levels in ASM exposed to albuterol (100 nM), 8-bromo-cAMP (300 microM), or the phosphodiesterase inhibitor isobutylmethylxanthine (100 microM).	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	25-30	cyclin D1	Homo sapiens	161-170
10531416-7	1999	The proteasome inhibitor MG132 (30 and 100 nM) and the calpain I inhibitor N-acetyl-Leu-Leu-leucinal (10 microM) attenuated the reduction in thrombin-stimulated cyclin D1 levels in ASM exposed to albuterol (100 nM), 8-bromo-cAMP (300 microM), or the phosphodiesterase inhibitor isobutylmethylxanthine (100 microM).	Albuterol	196-205	cyclin D1	Homo sapiens	161-170
10531416-7	1999	The proteasome inhibitor MG132 (30 and 100 nM) and the calpain I inhibitor N-acetyl-Leu-Leu-leucinal (10 microM) attenuated the reduction in thrombin-stimulated cyclin D1 levels in ASM exposed to albuterol (100 nM), 8-bromo-cAMP (300 microM), or the phosphodiesterase inhibitor isobutylmethylxanthine (100 microM).	1-Methyl-3-isobutylxanthine	278-300	cyclin D1	Homo sapiens	161-170
10530763-8	1999	However, mimosine does not affect transcription of these genes directly because significant changes in cyclin D1 or CDKI expression were observed at 12-24 h after drug addition.	Mimosine	9-17	cyclin D1	Homo sapiens	103-112
10935488-7	1999	Troglitazone treatment increased expression of two cyclin-dependent kinase inhibitors, p21(WAF1/CIP1) and p16(INK4), and reduced cyclin D1 expression, consistent with G1 arrest.	Troglitazone	0-12	cyclin D1	Homo sapiens	129-138
10511597-0	1999	Re: Cyclin D1 proteolysis: a retinoid chemoprevention signal in normal, immortalized, and transformed human bronchial epithelial cells.	Retinoids	29-37	cyclin D1	Homo sapiens	4-13
10519399-6	1999	AS cyclin D1 significantly inhibited cell proliferation by both [3H]thymidine incorporation in six SCC cell lines (P = 0.01-0.001) and the conversion of tetrazolium salt to formazan in four SCC cell lines (P = 0.01-0.004).	Tritium	65-67	cyclin D1	Homo sapiens	3-12
10519399-6	1999	AS cyclin D1 significantly inhibited cell proliferation by both [3H]thymidine incorporation in six SCC cell lines (P = 0.01-0.001) and the conversion of tetrazolium salt to formazan in four SCC cell lines (P = 0.01-0.004).	Thymidine	68-77	cyclin D1	Homo sapiens	3-12
10519399-6	1999	AS cyclin D1 significantly inhibited cell proliferation by both [3H]thymidine incorporation in six SCC cell lines (P = 0.01-0.001) and the conversion of tetrazolium salt to formazan in four SCC cell lines (P = 0.01-0.004).	Tetrazolium Salts	153-169	cyclin D1	Homo sapiens	3-12
10519399-6	1999	AS cyclin D1 significantly inhibited cell proliferation by both [3H]thymidine incorporation in six SCC cell lines (P = 0.01-0.001) and the conversion of tetrazolium salt to formazan in four SCC cell lines (P = 0.01-0.004).	Formazans	173-181	cyclin D1	Homo sapiens	3-12
10519756-4	1999	RESULTS: Positive immunostaining for MDM-2, proliferating cell nuclear antigen, cyclin D1, and cyclin A was occasionally observed in the large melanin-containing epithelioid cells.	Melanins	143-150	cyclin D1	Homo sapiens	80-89
10500157-0	1999	Estrogen induction of the cyclin D1 promoter: involvement of a cAMP response-like element.	Cyclic AMP	63-67	cyclin D1	Homo sapiens	26-35
10500157-8	1999	Furthermore, the expression of a dominant negative variant of c-Jun, TAM67, completely abolished the induction of the cyclin D1 promoter both in the absence and presence of ER.	tam67	69-74	cyclin D1	Homo sapiens	118-127
10493518-0	1999	Down-regulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol.	alvocidib	108-120	cyclin D1	Homo sapiens	19-28
10526133-3	1999	We looked at the expression of cyclin D1 in cortical neuronal cultures treated with either staurosporine to produce apoptotic death, or with glutamate, to produce a non-apoptotic death.	Staurosporine	91-104	cyclin D1	Homo sapiens	31-40
10526133-3	1999	We looked at the expression of cyclin D1 in cortical neuronal cultures treated with either staurosporine to produce apoptotic death, or with glutamate, to produce a non-apoptotic death.	Glutamic Acid	141-150	cyclin D1	Homo sapiens	31-40
10526133-5	1999	Following the addition of either staurosporine or glutamate, cyclin D1 immunoreactivity did not change within 4 h. The cyclin D1 immunoreactivity was lost by 6 h with the appearance of either staurosporine-induced fragmented nuclei or glutamate-induced pyknotic nuclei.	Staurosporine	33-46	cyclin D1	Homo sapiens	61-70
10526133-5	1999	Following the addition of either staurosporine or glutamate, cyclin D1 immunoreactivity did not change within 4 h. The cyclin D1 immunoreactivity was lost by 6 h with the appearance of either staurosporine-induced fragmented nuclei or glutamate-induced pyknotic nuclei.	Staurosporine	33-46	cyclin D1	Homo sapiens	119-128
10526133-5	1999	Following the addition of either staurosporine or glutamate, cyclin D1 immunoreactivity did not change within 4 h. The cyclin D1 immunoreactivity was lost by 6 h with the appearance of either staurosporine-induced fragmented nuclei or glutamate-induced pyknotic nuclei.	Glutamic Acid	50-59	cyclin D1	Homo sapiens	119-128
10526133-5	1999	Following the addition of either staurosporine or glutamate, cyclin D1 immunoreactivity did not change within 4 h. The cyclin D1 immunoreactivity was lost by 6 h with the appearance of either staurosporine-induced fragmented nuclei or glutamate-induced pyknotic nuclei.	Glutamic Acid	235-244	cyclin D1	Homo sapiens	119-128
10480882-6	1999	In accordance with its inhibitory action on protein synthesis, activation of cyclin D1 and p21 proteins by growth factors is also blocked by preincubation with rapamycin.	Sirolimus	160-169	cyclin D1	Homo sapiens	77-86
10493518-5	1999	In this work, we demonstrate that using isoform-specific antibodies, flavopiridol induces an early (by 6 h) decrease in cyclin D1 protein levels.	alvocidib	69-81	cyclin D1	Homo sapiens	120-129
10493518-9	1999	However, steady-state levels of cyclin D1 mRNA display a significant decrease by 4 h of flavopiridol treatment, with total disappearance by 8 h. This mRNA decline is not abrogated by the presence of cycloheximide.	alvocidib	88-100	cyclin D1	Homo sapiens	32-41
10493518-9	1999	However, steady-state levels of cyclin D1 mRNA display a significant decrease by 4 h of flavopiridol treatment, with total disappearance by 8 h. This mRNA decline is not abrogated by the presence of cycloheximide.	Cycloheximide	199-212	cyclin D1	Homo sapiens	32-41
10493518-10	1999	Furthermore, we have found that flavopiridol specifically represses the activity of the full-length cyclin D1 promoter linked to a luciferase reporter gene.	alvocidib	32-44	cyclin D1	Homo sapiens	100-109
10493518-11	1999	In summary, we have found that the flavopiridol-induced decline in cyclin D1 is an early event, specific and, at least in part, due to the transcriptional repression of the cyclin D1 promoter.	alvocidib	35-47	cyclin D1	Homo sapiens	67-76
10493518-11	1999	In summary, we have found that the flavopiridol-induced decline in cyclin D1 is an early event, specific and, at least in part, due to the transcriptional repression of the cyclin D1 promoter.	alvocidib	35-47	cyclin D1	Homo sapiens	173-182
10493518-12	1999	These results extend our understanding of flavopiridol"s action to include regulation of cyclin D1 transcription.	alvocidib	42-54	cyclin D1	Homo sapiens	89-98
10452682-2	1999	In this study, we investigated the expression of cyclin D1 in the formalin-fixed and paraffin-embedded human hepatocellular carcinoma (HCC) tissues of 25 patients, using monoclonal antibody 5D4 raised against cyclin D1.	Formaldehyde	66-74	cyclin D1	Homo sapiens	49-58
10499631-4	1999	Previous work exploring the growth-inhibitory activity of ATRA in human malignancies has implicated several mechanisms that can arrest cells in the G1 phase of the cell cycle, including activation of p21Waf1 and inhibition of cyclin D1 expression.	Tretinoin	58-62	cyclin D1	Homo sapiens	226-235
10419887-6	1999	Several other genes observed to be differentially expressed by homocysteine are known to mediate cell growth and differentiation (ie, GADD45, GADD153, Id-1, cyclin D1, FRA-2), a finding that supports the observation that homocysteine causes a dose-dependent decrease in DNA synthesis in HUVEC.	Homocysteine	63-75	cyclin D1	Homo sapiens	157-166
10480344-9	1999	There was thus a strong discrepancy between results for paraffin block and fresh samples, probably because of the short life of CCND1.	Paraffin	56-64	cyclin D1	Homo sapiens	128-133
10441105-6	1999	Induction of the cell cycle-related proteins cyclin D1, proliferating cell nuclear antigen, and phosphorylated retinoblastoma protein was also blocked by flavopiridol.	alvocidib	154-166	cyclin D1	Homo sapiens	45-54
10395294-0	1999	Magnesium depletion causes growth inhibition, reduced expression of cyclin D1, and increased expression of P27Kip1 in normal but not in transformed mammary epithelial cells.	Magnesium	0-9	cyclin D1	Homo sapiens	68-77
10395294-6	1999	Extracellular magnesium depletion was associated with increased expression of the cyclin-dependent kinase inhibitor p27Kip1 and decreased expression of cyclin D1 in the HC11 but not in the MCF-7 cells.	Magnesium	14-23	cyclin D1	Homo sapiens	152-161
10645225-5	1999	METHODS: Cyclin D1 immunohistochemistry was performed on 17 paraffin embedded Kaposi sarcoma samples from 16 patients.	Paraffin	60-68	cyclin D1	Homo sapiens	9-18
10452682-2	1999	In this study, we investigated the expression of cyclin D1 in the formalin-fixed and paraffin-embedded human hepatocellular carcinoma (HCC) tissues of 25 patients, using monoclonal antibody 5D4 raised against cyclin D1.	Paraffin	85-93	cyclin D1	Homo sapiens	49-58
10416617-5	1999	The suppression of cyclin D1 expression after the stable transfection of a cyclin D1 antisense construct in PANC-1 and COLO-357 human pancreatic cancer cells resulted in a significant increase in sensitivity to the fluoropyrimidines 5-fluorouracil and 5-fluoro-2"-deoxyuridine and to mitoxantrone.	fluoropyrimidines	215-232	cyclin D1	Homo sapiens	19-28
10419526-0	1999	Retinoic acid promotes ubiquitination and proteolysis of cyclin D1 during induced tumor cell differentiation.	Tretinoin	0-13	cyclin D1	Homo sapiens	57-66
10419526-2	1999	This study demonstrates that retinoids promote ubiquitination and degradation of cyclin D1 during retinoid-induced differentiation of human embryonal carcinoma cells.	Retinoids	29-38	cyclin D1	Homo sapiens	81-90
10419526-2	1999	This study demonstrates that retinoids promote ubiquitination and degradation of cyclin D1 during retinoid-induced differentiation of human embryonal carcinoma cells.	Retinoids	29-37	cyclin D1	Homo sapiens	81-90
10419526-3	1999	In response to all-trans-retinoic acid (RA) treatment, the human embryonal carcinoma cell line NT2/D1 exhibits a progressive decline in cyclin D1 expression beginning when the cells are committed to differentiate, but before onset of terminal neuronal differentiation.	Tretinoin	15-38	cyclin D1	Homo sapiens	136-145
10419526-3	1999	In response to all-trans-retinoic acid (RA) treatment, the human embryonal carcinoma cell line NT2/D1 exhibits a progressive decline in cyclin D1 expression beginning when the cells are committed to differentiate, but before onset of terminal neuronal differentiation.	Tretinoin	40-42	cyclin D1	Homo sapiens	136-145
10419526-7	1999	The proteasome inhibitor LLnL blocks this RA-mediated decline in cyclin D1.	Tretinoin	42-44	cyclin D1	Homo sapiens	65-74
10419526-8	1999	RA treatment markedly accelerates ubiquitination of wild-type cyclin D1, but not a cyclin D1 (T286A) mutant.	Tretinoin	0-2	cyclin D1	Homo sapiens	62-71
10419526-9	1999	Transient expression of cyclin D1 (T286A) in NT2/D1 cells blocks RA-mediated transcriptional decline of a differentiation-sensitive reporter plasmid and represses induction of immunophenotypic neuronal markers.	Tretinoin	65-67	cyclin D1	Homo sapiens	24-33
10419526-10	1999	Taken together, these findings strongly implicate RA-mediated degradation of cyclin D1 as a means of coupling induced differentiation and cell cycle control of human embryonal carcinoma cells.	Tretinoin	50-52	cyclin D1	Homo sapiens	77-86
10411905-3	1999	Cyclin D1 protein synthesis was rapidly inhibited by tunicamycin treatment.	Tunicamycin	53-64	cyclin D1	Homo sapiens	0-9
10411905-6	1999	Enforced overexpression of cyclin D1 in tunicamycin-treated cells maintained cyclin D- and E-dependent kinase activities and kept cells in cycle in the face of a fully activated UPR.	Tunicamycin	40-51	cyclin D1	Homo sapiens	27-36
10416617-5	1999	The suppression of cyclin D1 expression after the stable transfection of a cyclin D1 antisense construct in PANC-1 and COLO-357 human pancreatic cancer cells resulted in a significant increase in sensitivity to the fluoropyrimidines 5-fluorouracil and 5-fluoro-2"-deoxyuridine and to mitoxantrone.	fluoropyrimidines	215-232	cyclin D1	Homo sapiens	75-84
10416617-5	1999	The suppression of cyclin D1 expression after the stable transfection of a cyclin D1 antisense construct in PANC-1 and COLO-357 human pancreatic cancer cells resulted in a significant increase in sensitivity to the fluoropyrimidines 5-fluorouracil and 5-fluoro-2"-deoxyuridine and to mitoxantrone.	Fluorouracil	233-247	cyclin D1	Homo sapiens	19-28
10416617-5	1999	The suppression of cyclin D1 expression after the stable transfection of a cyclin D1 antisense construct in PANC-1 and COLO-357 human pancreatic cancer cells resulted in a significant increase in sensitivity to the fluoropyrimidines 5-fluorouracil and 5-fluoro-2"-deoxyuridine and to mitoxantrone.	Fluorouracil	233-247	cyclin D1	Homo sapiens	75-84
10416617-5	1999	The suppression of cyclin D1 expression after the stable transfection of a cyclin D1 antisense construct in PANC-1 and COLO-357 human pancreatic cancer cells resulted in a significant increase in sensitivity to the fluoropyrimidines 5-fluorouracil and 5-fluoro-2"-deoxyuridine and to mitoxantrone.	5-fluoro-2'-deoxyuridine	252-276	cyclin D1	Homo sapiens	19-28
10416617-5	1999	The suppression of cyclin D1 expression after the stable transfection of a cyclin D1 antisense construct in PANC-1 and COLO-357 human pancreatic cancer cells resulted in a significant increase in sensitivity to the fluoropyrimidines 5-fluorouracil and 5-fluoro-2"-deoxyuridine and to mitoxantrone.	5-fluoro-2'-deoxyuridine	252-276	cyclin D1	Homo sapiens	75-84
10416617-5	1999	The suppression of cyclin D1 expression after the stable transfection of a cyclin D1 antisense construct in PANC-1 and COLO-357 human pancreatic cancer cells resulted in a significant increase in sensitivity to the fluoropyrimidines 5-fluorouracil and 5-fluoro-2"-deoxyuridine and to mitoxantrone.	Mitoxantrone	284-296	cyclin D1	Homo sapiens	19-28
10416617-5	1999	The suppression of cyclin D1 expression after the stable transfection of a cyclin D1 antisense construct in PANC-1 and COLO-357 human pancreatic cancer cells resulted in a significant increase in sensitivity to the fluoropyrimidines 5-fluorouracil and 5-fluoro-2"-deoxyuridine and to mitoxantrone.	Mitoxantrone	284-296	cyclin D1	Homo sapiens	75-84
10385595-5	1999	PD98059 (10 microM), an inhibitor of MEK1 activation, markedly attenuated thrombin stimulation of ERK activity and phosphorylation, DNA synthesis, and cyclin D1 levels.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	0-7	cyclin D1	Homo sapiens	151-160
10366423-3	1999	Rb phosphorylation, cyclin D1 expression, and cdk2 activation in G1 progression were all inhibited by NA22598, but the amounts of cdk2 and p27 were not affected.	na22598	102-109	cyclin D1	Homo sapiens	20-29
10652602-5	1999	Analysis of G1 regulatory proteins demonstrated that the protein levels of cyclin-dependent kinase (CDK) 2, CDK4, CDK6 and cyclin E were decreased after treatment with lovastatin (10 microM) in a time-dependent manner, but not cyclin D1.	Lovastatin	168-178	cyclin D1	Homo sapiens	227-236
10430085-6	1999	In vitro treatment of HCT116 cells with AS-Rb decreased the level of pRb by about 70% and also decreased the levels of the cyclin D1 protein and cyclin D1-associated kinase activity.	as-rb	40-45	cyclin D1	Homo sapiens	123-132
10430085-6	1999	In vitro treatment of HCT116 cells with AS-Rb decreased the level of pRb by about 70% and also decreased the levels of the cyclin D1 protein and cyclin D1-associated kinase activity.	as-rb	40-45	cyclin D1	Homo sapiens	145-154
10504527-0	1999	Molecular cytogenetic identification of cyclin D1 gene amplification in a renal pelvic tumor attributed to phenacetin abuse.	Phenacetin	107-117	cyclin D1	Homo sapiens	40-49
10504527-6	1999	In the absence of p53, Rb or c-myc abnormalities, the results suggested that cyclin D1 gene amplification and its protein overexpression may be involved in the genesis of renal pelvic carcinomas associated with phenacetin abuse.	Phenacetin	211-221	cyclin D1	Homo sapiens	77-86
10377442-5	1999	Silibinin-induced G1 arrest was associated with a marked decrease in the kinase activity of cyclin-dependent kinases (CDKs) and associated cyclins because of a highly significant decrease in cyclin D1, CDK4, and CDK6 levels and an induction of Cip1/p21 and Kip1/p27 followed by their increased binding with CDK2.	Silybin	0-9	cyclin D1	Homo sapiens	191-200
10366423-0	1999	NA22598, a novel antitumor compound, reduces cyclin D1 levels, arrests cell cycle at G1 phase, and inhibits anchorage-independent growth of human tumor cells.	na22598	0-7	cyclin D1	Homo sapiens	45-54
10652628-5	1999	Alcohol-induced overexpression of EGFR is paralleled by increased cyclin D1 expression.	Alcohols	0-7	cyclin D1	Homo sapiens	66-75
10375610-5	1999	Western analysis revealed that flavopiridol treatment resulted in depletion of both cyclin E and D1, suggesting that loss of the regulatory subunits is at least partially responsible for the loss of Cdk kinase activity.	alvocidib	31-43	cyclin D1	Homo sapiens	84-99
11721429-2	1999	METHODS: Immunohistochemistry was used to detect the expression of cyclin D1, D2, D3 in 43 samples of childhood AL patients and three leukemic cell lines.	Aluminum	112-114	cyclin D1	Homo sapiens	67-76
11721429-5	1999	Cyclin D1 was overexpressed in 5% (2/43) of the AL patients.	Aluminum	48-50	cyclin D1	Homo sapiens	0-9
11721432-4	1999	Among leukemia patients, the rate of cyclin D1 expression was 26.2%, and the highest(63.6%) rate was in the relapse group and the lowest(8.3%) in the CR group.	Chromium	150-152	cyclin D1	Homo sapiens	37-46
10366423-4	1999	Among these effects the inhibition of cyclin D1 expression was most prominent, and NA22598 was found to inhibit the synthesis of cyclin D1 without affecting mRNA expression or protein degradation.	na22598	83-90	cyclin D1	Homo sapiens	129-138
10366423-8	1999	An agent, like NA22598, which induces the downregulation of cyclin D1 might offer a new anticancer strategy.	na22598	15-22	cyclin D1	Homo sapiens	60-69
10328955-0	1999	Dysregulated expression of cyclin D1 in normal human mammary epithelial cells inhibits all-trans-retinoic acid-mediated G0/G1-phase arrest and differentiation in vitro.	Tretinoin	87-110	cyclin D1	Homo sapiens	27-36
10401624-5	1999	4-Hydroxynonenal downregulated both mRNA and protein contents of cyclins D1, D2, and A until 24 h from the treatments, whereas DMSO inhibited cyclin D1 and D2 expression until the end of experiment (2 days) and induces an increase of cyclin A until 1 day.	Dimethyl Sulfoxide	127-131	cyclin D1	Homo sapiens	142-151
10328955-2	1999	We investigated whether retroviral-mediated expression of cyclin D1 might affect all-trans-retinoic acid (ATRA)-mediated growth inhibition and differentiation of normal cultured human mammary epithelial cells (HMECs).	Tretinoin	84-104	cyclin D1	Homo sapiens	58-67
10328955-2	1999	We investigated whether retroviral-mediated expression of cyclin D1 might affect all-trans-retinoic acid (ATRA)-mediated growth inhibition and differentiation of normal cultured human mammary epithelial cells (HMECs).	Tretinoin	106-110	cyclin D1	Homo sapiens	58-67
10328955-6	1999	Dysregulated expression of cyclin D1 in HMECs results in inhibition of G0/G1-phase arrest mediated by ATRA.	Tretinoin	102-106	cyclin D1	Homo sapiens	27-36
10328955-8	1999	Our results suggest that coordinated expression of cyclin D1 may be critical for normal mammary epithelial cell homeostasis, and dysregulated expression of cyclin D1 might result in retinoid resistance and promote mammary carcinogenesis.	Retinoids	182-190	cyclin D1	Homo sapiens	156-165
10205781-4	1999	The cyclin D1 mRNA expression level relative to beta-tubulin was determined by 32P phosphoimager analysis.	Phosphorus-32	79-82	cyclin D1	Homo sapiens	4-13
10329719-3	1999	ERK activity was approximately 2-fold higher in cycling BMM compared with growth-arrested BMM; in addition, CSF-1-stimulated BMM DNA synthesis was partially inhibited by PD98059, a specific inhibitor of MEK activation, suggesting a role for a mitogen-activated protein-ERK kinase (MEK)/ERK pathway in the control of DNA synthesis but surprisingly not in the control of cyclin D1 mRNA or c-myc mRNA expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	170-177	cyclin D1	Homo sapiens	369-378
10344760-5	1999	Cyclin D1 was not expressed in normal bronchial epithelium but was detected in 7% of SMs, 15% of atypias; 18% of LGDs, 47% of HGDs, and 42% of SCCs.	Samarium	85-88	cyclin D1	Homo sapiens	0-9
10329598-6	1999	So far, IGH-CCND1 fusions have been detected in all of the 51 MCL patients that we have analyzed by FISH (either on paraffin-embedded tumor samples or on peripheral blood samples).	Paraffin	116-124	cyclin D1	Homo sapiens	12-17
10233583-7	1999	Western blots showed that the expression of cell cycle-dependent kinases (cdk2 and cdk4), cyclin D1 and p53 was significantly reduced, while WAF1 was increased, after BFA treatment.	Brefeldin A	167-170	cyclin D1	Homo sapiens	90-99
10229506-0	1999	Expression of cyclin D1 in parathyroid carcinomas, adenomas, and hyperplasias: a paraffin immunohistochemical study.	Paraffin	81-89	cyclin D1	Homo sapiens	14-23
10096245-2	1999	The percentage of CD1-positive cells was especially high in node-negative (N-) estrogen-receptor-positive (ER+) tumors, probably as a consequence of CD1 induction by estrogens in steroid-responsive tissues.	Steroids	179-186	cyclin D1	Homo sapiens	18-21
10096245-2	1999	The percentage of CD1-positive cells was especially high in node-negative (N-) estrogen-receptor-positive (ER+) tumors, probably as a consequence of CD1 induction by estrogens in steroid-responsive tissues.	Steroids	179-186	cyclin D1	Homo sapiens	149-152
10096245-4	1999	An interesting relationship between CD1 expression and H3-thymidine labelling index (H3Td-LI) was also found: CD1 and H3Td-LI were unrelated in N- tumors, while high CD1 expression was observed in N+ tumors with high DNA synthesis, as assessed by H3Td-LI.	Thymidine	58-67	cyclin D1	Homo sapiens	36-39
10096245-4	1999	An interesting relationship between CD1 expression and H3-thymidine labelling index (H3Td-LI) was also found: CD1 and H3Td-LI were unrelated in N- tumors, while high CD1 expression was observed in N+ tumors with high DNA synthesis, as assessed by H3Td-LI.	Thymidine	58-67	cyclin D1	Homo sapiens	110-113
10096245-4	1999	An interesting relationship between CD1 expression and H3-thymidine labelling index (H3Td-LI) was also found: CD1 and H3Td-LI were unrelated in N- tumors, while high CD1 expression was observed in N+ tumors with high DNA synthesis, as assessed by H3Td-LI.	Thymidine	58-67	cyclin D1	Homo sapiens	110-113
10229197-9	1999	Expression of gelsolin, cyclin E and Cdk inhibitors including p21WAF1/Cip1 was highly augmented, while that of cyclin A and cyclin D1 was decreased by oxamflatin.	oxamflatin	151-161	cyclin D1	Homo sapiens	124-133
10082535-8	1999	Impaired cell cycle progression of T47D cells expressing an NF-kappaB superrepressor (IkappaBalphaDeltaN) could be rescued by ectopic expression of cyclin D1.	ikappabalphadeltan	86-104	cyclin D1	Homo sapiens	148-157
10070974-4	1999	MCF7 cells cultured without tetracycline resulted in a 6-fold increase in the cyclin D1 protein.	Tetracycline	28-40	cyclin D1	Homo sapiens	78-87
10092070-3	1999	By using a microvolume fluorimeter integrated with a thermal cycler and the PCR compatible double-stranded DNA (dsDNA) binding dye SYBR Green I, we simultaneously amplified and detected bcl-1/JH translocation products by using rapid cycle PCR and fluorescence melting curve analysis.	SYBR Green I	131-143	cyclin D1	Homo sapiens	186-191
10037171-0	1999	Alterations of Rb pathway (Rb-p16INK4-cyclin D1) in preinvasive bronchial lesions.	Rubidium	15-17	cyclin D1	Homo sapiens	38-47
10022898-4	1999	Accordingly, cyclin D1-associated phosphorylation of pRb at Ser-780 is lacking even in newly senescent fibroblasts that have a low amount of p16.	Serine	60-63	cyclin D1	Homo sapiens	13-22
10050790-3	1999	METHODS: Using an immunohistochemical method, we assessed for cyclin D1 expression in 8 breast papillomas and 6 papillary carcinomas, all of which were formalin fixed, routinely processed, and paraffin embedded.	Formaldehyde	152-160	cyclin D1	Homo sapiens	62-71
10050872-0	1999	Cyclin D1 proteolysis: a retinoid chemoprevention signal in normal, immortalized, and transformed human bronchial epithelial cells.	Retinoids	25-33	cyclin D1	Homo sapiens	0-9
10050872-4	1999	Recently, the all-trans-retinoic acid (RA)-induced proteolysis of cyclin D1 that leads to the arrest of cells in G1 phase of the cell cycle was described in human bronchial epithelial cells and is a promising candidate for such a mechanism.	Tretinoin	14-37	cyclin D1	Homo sapiens	66-75
10050872-4	1999	Recently, the all-trans-retinoic acid (RA)-induced proteolysis of cyclin D1 that leads to the arrest of cells in G1 phase of the cell cycle was described in human bronchial epithelial cells and is a promising candidate for such a mechanism.	Tretinoin	39-41	cyclin D1	Homo sapiens	66-75
10050872-8	1999	RESULTS: Receptor-nonselective retinoids were superior to the carotenoids studied in mediating the decline in cyclin D1 expression and in suppressing the growth of bronchial epithelial cells.	Retinoids	31-40	cyclin D1	Homo sapiens	110-119
10050872-8	1999	RESULTS: Receptor-nonselective retinoids were superior to the carotenoids studied in mediating the decline in cyclin D1 expression and in suppressing the growth of bronchial epithelial cells.	Carotenoids	62-73	cyclin D1	Homo sapiens	110-119
10050872-10	1999	The retinoid-mediated degradation of cyclin D1 was blocked by cotreatment with calpain inhibitor I.	Retinoids	4-12	cyclin D1	Homo sapiens	37-46
10050872-11	1999	CONCLUSIONS: Retinoid-dependent cyclin D1 proteolysis is a common chemoprevention signal in normal and neoplastic human bronchial epithelial cells.	Retinoids	13-21	cyclin D1	Homo sapiens	32-41
10050872-13	1999	Thus, the degradation of cyclin D1 is a candidate intermediate marker for effective retinoid-mediated cancer chemoprevention in the aerodigestive tract.	Retinoids	84-92	cyclin D1	Homo sapiens	25-34
10037171-8	1999	Our results indicate that Rb protein function can be invalidated before invasion through alteration of the Rb phosphorylation pathway, by p16 inhibition, and/or by cyclin D1 overexpression and suggest a role for p16 and cyclin D1 deregulation in progression of preinvasive bronchial lesions to invasive carcinoma.	Rubidium	26-28	cyclin D1	Homo sapiens	164-173
10037171-8	1999	Our results indicate that Rb protein function can be invalidated before invasion through alteration of the Rb phosphorylation pathway, by p16 inhibition, and/or by cyclin D1 overexpression and suggest a role for p16 and cyclin D1 deregulation in progression of preinvasive bronchial lesions to invasive carcinoma.	Rubidium	26-28	cyclin D1	Homo sapiens	220-229
10051745-2	1999	Here we show that inhibition of calcium entry into cerebellar neurons by switching from high to low extracellular K+ concentrations (30-5 mM) induces apoptosis, that correlates with a rapid accumulation of cyclin D1 (CD1), an early marker of the G1/S transition of the cell cycle.	Calcium	32-39	cyclin D1	Homo sapiens	206-215
10051745-2	1999	Here we show that inhibition of calcium entry into cerebellar neurons by switching from high to low extracellular K+ concentrations (30-5 mM) induces apoptosis, that correlates with a rapid accumulation of cyclin D1 (CD1), an early marker of the G1/S transition of the cell cycle.	Calcium	32-39	cyclin D1	Homo sapiens	217-220
10051745-3	1999	These effects on apoptosis and cyclin D1 are mimicked either by blocking calcium entry into neurons (LaCl3, 100 microM or nifedipine, 10(-6) M) or by inhibiting the calcium/calmodulin pathway (calmidazolium, 10(-7) M).	Calcium	73-80	cyclin D1	Homo sapiens	31-40
10051745-3	1999	These effects on apoptosis and cyclin D1 are mimicked either by blocking calcium entry into neurons (LaCl3, 100 microM or nifedipine, 10(-6) M) or by inhibiting the calcium/calmodulin pathway (calmidazolium, 10(-7) M).	lanthanum chloride	101-106	cyclin D1	Homo sapiens	31-40
10051745-3	1999	These effects on apoptosis and cyclin D1 are mimicked either by blocking calcium entry into neurons (LaCl3, 100 microM or nifedipine, 10(-6) M) or by inhibiting the calcium/calmodulin pathway (calmidazolium, 10(-7) M).	Nifedipine	122-132	cyclin D1	Homo sapiens	31-40
10051745-3	1999	These effects on apoptosis and cyclin D1 are mimicked either by blocking calcium entry into neurons (LaCl3, 100 microM or nifedipine, 10(-6) M) or by inhibiting the calcium/calmodulin pathway (calmidazolium, 10(-7) M).	calmidazolium	193-206	cyclin D1	Homo sapiens	31-40
9949353-6	1999	To explore the role played by cyclin D1 in the pathogenesis of thyroid papillary carcinoma, we have quantitated, by computerized image analysis, the immunohistochemical expression of cyclin D1 in formalin-fixed, paraffin-embedded tissue from 35 conventional papillary carcinomas of the thyroid and correlated the results with established clinicopathologic parameters and available survival data.	Formaldehyde	196-204	cyclin D1	Homo sapiens	183-192
9891045-4	1999	Induction of c-Myc mRNA by Raf was an immediate-early response, whereas the induction of cyclin D1 mRNA was delayed and inhibited by cycloheximide.	Cycloheximide	133-146	cyclin D1	Homo sapiens	89-98
9891045-10	1999	Furthermore, the induction of c-Myc and cyclin D1 by oncogenes and growth factors was inhibited by PD098059, a specific MAP kinase kinase (MEK) inhibitor.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	99-107	cyclin D1	Homo sapiens	40-49
9949353-6	1999	To explore the role played by cyclin D1 in the pathogenesis of thyroid papillary carcinoma, we have quantitated, by computerized image analysis, the immunohistochemical expression of cyclin D1 in formalin-fixed, paraffin-embedded tissue from 35 conventional papillary carcinomas of the thyroid and correlated the results with established clinicopathologic parameters and available survival data.	Paraffin	212-220	cyclin D1	Homo sapiens	183-192
11601206-6	1999	The activities of cyclin E/CDK2 and the amounts of cyclin D1/CDK4 complexes were decreased in ATRA- or AE-treated HL-60 cells.	Tretinoin	94-98	cyclin D1	Homo sapiens	51-60
11601206-6	1999	The activities of cyclin E/CDK2 and the amounts of cyclin D1/CDK4 complexes were decreased in ATRA- or AE-treated HL-60 cells.	alanylglutamic acid	103-105	cyclin D1	Homo sapiens	51-60
11819376-2	1999	So,it is easy to generate digoxigenin (DIG)-labeled RNA probes of antisense and sense to cyclin D1 using RKSD1 as a template vector.	Digoxigenin	26-37	cyclin D1	Homo sapiens	89-98
11819376-2	1999	So,it is easy to generate digoxigenin (DIG)-labeled RNA probes of antisense and sense to cyclin D1 using RKSD1 as a template vector.	Digoxigenin	39-42	cyclin D1	Homo sapiens	89-98
12080677-1	1999	In order to investigate the relationship between the regulators of cell cycle and cutaneous squamous cell carcinoma(SCC), we used an immunohistochemical staining technique to examine the expression of cyclin D1, p16 and Rb in the paraffin embedded skin cancer tissues of 30 patients with SCC.	Paraffin	230-238	cyclin D1	Homo sapiens	201-210
10481784-3	1999	Gsp gene, that may play an important role in 40% of GH-producing tumor, activation of 10% of non-functioning tumors and 6% of corticotroph adenomas, produces cAMP, which stimulates cyclin D1 and D3 which later produce cdk2 and cdk4 respectively, and stimulates cell progression from G1 to S phase.	Cyclic AMP	158-162	cyclin D1	Homo sapiens	181-190
9790790-0	1998	Control of cyclin D1 expression by antisense oligonucleotides in three ovarian cancer cell lines.	Oligonucleotides	45-61	cyclin D1	Homo sapiens	11-20
10489163-4	1999	In addition, 1alpha,25-(OH)2D3 significantly reduced basal and EGF-stimulated expression of cyclin D1 at the mRNA and protein level in primary cultures as well as in the Caco-2 cell line.	25-(oh)2d3	20-30	cyclin D1	Homo sapiens	92-101
9829756-4	1998	Western blot analysis revealed diminution of cyclin D1, Rb, and p107 protein levels after flavopiridol exposure.	alvocidib	90-102	cyclin D1	Homo sapiens	45-54
9802881-8	1998	Flavopiridol treatment also resulted in a remarkable reduction of cyclin D1 expression in HNSCC cells and tumor xenografts.	alvocidib	0-12	cyclin D1	Homo sapiens	66-75
9811181-1	1998	Cyclin D1 and cyclin E are the mammalian G1 cydins that are both required and rate limiting for entry into S phase.	cydins	44-50	cyclin D1	Homo sapiens	0-9
9724094-4	1998	Cyclin D1 and cdk4 expression and Rb phosphorylation were significantly reduced, by 40-75%, after 24 hr of treatment with RA or 4HPR; these decreases were either transient, e.g., only at 24 hr for cdk4, or sustained for 72 hr.	Fenretinide	128-132	cyclin D1	Homo sapiens	0-9
9728041-9	1998	The effect of IL-4 (50 ng/ml), PGE2 (1 microM), and forskolin (10 microM) on cyclin D1 protein expression in 10% FBS-stimulated human airway smooth muscle cells was also examined.	Colforsin	52-61	cyclin D1	Homo sapiens	77-86
9846986-3	1998	In the current study performed on paraffin-embedded tissue, cyclin D1 mRNA could be detected in 23 of 24 mantle-cell lymphomas by reverse transcription polymerase chain reaction (RT-PCR) whereas only 9 of 24 demonstrated a t(11;14) by PCR.	Paraffin	34-42	cyclin D1	Homo sapiens	60-69
9846986-8	1998	This assay for cyclin D1 expression, designed for formalin-fixed, paraffin-embedded tissue, was a very sensitive and specific marker for mantle-cell lymphoma.	Formaldehyde	50-58	cyclin D1	Homo sapiens	15-24
9846986-8	1998	This assay for cyclin D1 expression, designed for formalin-fixed, paraffin-embedded tissue, was a very sensitive and specific marker for mantle-cell lymphoma.	Paraffin	66-74	cyclin D1	Homo sapiens	15-24
9860134-10	1998	The expression of cyclin D1 was slightly more suppressed than total protein synthesis after addition of CD during that reactivation process.	Cytochalasin D	104-106	cyclin D1	Homo sapiens	18-27
11245009-4	1998	We then constructed the antisense cyclin D1 vector and transfected the PC-7 cell line with lipofectin.	1,2-dielaidoylphosphatidylethanolamine	91-101	cyclin D1	Homo sapiens	34-43
9747885-7	1998	A potential explanation for this difference was provided by the observation that in ER positive breast cancer cells oestradiol treatment resulted in increased cyclin D1 gene expression but was without effect on EMS1.	Estradiol	116-126	cyclin D1	Homo sapiens	159-168
9683804-0	1998	Differential effects of estradiol and its analogs on cyclin D1 and CDK4 expression in estrogen receptor positive MCF-7 and estrogen receptor-transfected MCF-10AEwt5 cells.	Estradiol	24-33	cyclin D1	Homo sapiens	53-62
9683804-8	1998	The least effective analog in inducing cyclin D1 was 3-hydroxyestratriene.	3-hydroxyestratriene	53-73	cyclin D1	Homo sapiens	39-48
9738577-4	1998	Cyclin D1 overexpression was significantly associated with tobacco smoking and alcohol consumption, tumor extension, advanced clinical stage, and the presence of lymph node metastases.	Alcohols	79-86	cyclin D1	Homo sapiens	0-9
9783903-0	1998	Action of 1,25(OH)2D3 on the cell cycle genes, cyclin D1, p21 and p27 in MCF-7 cells.	Calcitriol	10-21	cyclin D1	Homo sapiens	47-56
9705214-9	1998	For example, TCDD significantly inhibited E2-induced hyperphosphorylation of RB, cyclin D1 protein, and cdk2-, cdk4-, and cdk7-dependent kinase activities.	Polychlorinated Dibenzodioxins	13-17	cyclin D1	Homo sapiens	81-90
9705214-10	1998	Inhibition of E2-induced cdk4-dependent kinase activity by TCDD may be related to the parallel decrease of E2-induced cyclin D1 protein, and inhibition of induced cdk2- and cdk4-dependent kinase activities may be due to significantly increased p21 levels in cells cotreated with TCDD plus E2.	Polychlorinated Dibenzodioxins	59-63	cyclin D1	Homo sapiens	118-127
9671459-2	1998	To investigate the potential contribution of these proteins to estrogen action, we derived clonal MCF-7 breast cancer cell lines in which c-Myc or cyclin D1 was expressed under the control of the metal-inducible metallothionein promoter.	Metals	196-201	cyclin D1	Homo sapiens	147-156
9671459-3	1998	Inducible expression of either c-Myc or cyclin D1 was sufficient for S-phase entry in cells previously arrested in G1 phase by pretreatment with ICI 182780, a potent estrogen antagonist.	Fulvestrant	145-155	cyclin D1	Homo sapiens	40-49
9783903-4	1998	Cyclin D1 transcription levels decreased rapidly in 1,25(OH)2D3-treated cells while protein levels only decreased after 72 h of treatment.	Calcitriol	52-63	cyclin D1	Homo sapiens	0-9
9692552-6	1998	RIE-1 cells were engineered to overexpress human cyclin D1 under the control of a tetracycline-repressible promoter.	Tetracycline	82-94	cyclin D1	Homo sapiens	49-58
9692552-7	1998	These cells entered S phase in the presence of TGF-beta1 only when human cyclin D1 was derepressed by the withdrawal of tetracycline.	Tetracycline	120-132	cyclin D1	Homo sapiens	73-82
9655688-6	1998	The human ITF promoter contained an 11-residue consensus sequence with high homology to the butyrate response element of the cyclin D1 gene.	Butyrates	92-100	cyclin D1	Homo sapiens	125-134
9658403-7	1998	Indeed, Northern analysis showed that Rap, KN62, and, to a lesser degree, FK506 inhibited progestin stimulation of Cyclin D1 mRNA levels, but not those of the non-steroid-regulated glyceraldehyde 3-phosphate dehydrogenase (GAPDH) gene.	Tacrolimus	74-79	cyclin D1	Homo sapiens	115-124
10923489-2	1998	METHODS: We first detected the expression of Cyclin D1 protein in mesangial cells by using immunohistochemical method, set up a retroviral vector mediated genetransfer system expressing Cyclin D1 antisense RNA with recombinating techniques, and assay the proliferating situation of genetransferred mesangial cells by MTT method and flow cytometry respectively.	monooxyethylene trimethylolpropane tristearate	317-320	cyclin D1	Homo sapiens	186-195
9688179-7	1998	We analyzed the expression of cyclin D1 nuclear protein in paraffin sections using an immunoperoxidase technique in 17 cases diagnosed as SMZL.	Paraffin	59-67	cyclin D1	Homo sapiens	30-39
9655257-13	1998	The data suggest that HMBA-induced growth inhibition is due to multifactorial mechanisms involving decreases in total cyclin D1 and inhibition of cdk4 and cdk6 kinase activities through elevation of levels of cdk4- and cdk6-associated p27Kip1 and concomitant increases in hypophosphorylated pRb and stable cyclin D2/pRb and cyclin D3/pRb complexes that help maintain pRb in a functional state.	hexamethylene bisacetamide	22-26	cyclin D1	Homo sapiens	118-127
9610736-2	1998	We now show that UV irradiation of B16 melanoma after prior exposure to the radiation sensitizer, bromodeoxyuridine (BUdR) leads to induction of p53 and DNA fragmentation, and concomitant decreases in Rb, E2F, cyclin D1, and cell viability, with no comparable effects on irradiated unsensitized cells.	Bromodeoxyuridine	98-115	cyclin D1	Homo sapiens	210-219
10200487-4	1998	The addition of exogenous, cell-permeable C2-ceramide to the Hs 27 human diploid fibroblast cell line resulted in a dose-dependent induction of the p21WAF1/CIP1/Sdi1 kinase inhibitor with reduction of cyclin-D1 associated kinase activity.	N-acetylsphingosine	42-53	cyclin D1	Homo sapiens	201-210
9852627-0	1998	Involvement of apoptosis and cyclin D1 gene repression in growth inhibition of T-47D human breast cancer cells by methylglyoxal bis(cyclopentylamidinohydrazone).	methylglyoxal bis(cyclopentylamidinohydrazone)	114-159	cyclin D1	Homo sapiens	29-38
9852627-4	1998	The gene expression of cyclin D1 was also repressed by the MGBCP treatment.	methylglyoxal bis(cyclopentylamidinohydrazone)	59-64	cyclin D1	Homo sapiens	23-32
9852627-7	1998	These findings suggest that the inhibition of polyamine synthesis results in the repressions of cyclin D1 expression and cell cycle progression, eventually inducing apoptosis in these human breast cancer cells.	Polyamines	46-55	cyclin D1	Homo sapiens	96-105
9652748-10	1998	Preincubation with PD98059 blocked the HRG-dependent induction of cyclin D1 mRNA, p21 and c-Myc protein and pRB phosphorylation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	19-26	cyclin D1	Homo sapiens	66-75
9606972-2	1998	Here we report that both cobalt and the calcium chelator EGTA, inhibitors of calcium uptake, as well as cyclosporin A and FK-506, specific inhibitors of calcineurin function, abolished fibroblast growth factor (FGF)-induced expression of cyclins A and E, but not cyclin D1.	Cobalt	25-31	cyclin D1	Homo sapiens	263-272
9606972-2	1998	Here we report that both cobalt and the calcium chelator EGTA, inhibitors of calcium uptake, as well as cyclosporin A and FK-506, specific inhibitors of calcineurin function, abolished fibroblast growth factor (FGF)-induced expression of cyclins A and E, but not cyclin D1.	Calcium	40-47	cyclin D1	Homo sapiens	263-272
9606972-2	1998	Here we report that both cobalt and the calcium chelator EGTA, inhibitors of calcium uptake, as well as cyclosporin A and FK-506, specific inhibitors of calcineurin function, abolished fibroblast growth factor (FGF)-induced expression of cyclins A and E, but not cyclin D1.	Egtazic Acid	57-61	cyclin D1	Homo sapiens	263-272
9606972-2	1998	Here we report that both cobalt and the calcium chelator EGTA, inhibitors of calcium uptake, as well as cyclosporin A and FK-506, specific inhibitors of calcineurin function, abolished fibroblast growth factor (FGF)-induced expression of cyclins A and E, but not cyclin D1.	Tacrolimus	122-128	cyclin D1	Homo sapiens	263-272
9581834-8	1998	In the studies analyzing cell cycle regulatory molecules, silymarin treatment of cells also resulted in a significant induction of cyclin-dependent kinase inhibitors (CDKIs) Cip1/p21 and Kip1/p27, concomitant with a significant decrease in CDK4 expression, but no change in the levels of CDK2 and CDK6 and their associated cyclins E and D1, respectively.	Silymarin	58-67	cyclin D1	Homo sapiens	323-339
9591774-5	1998	We also detected higher levels of Rb phosphorylation and E2F-1 protein levels in LNCaP/cyclin D1 cells than that in the parental and vector control cells in medium with or without androgen.	Rubidium	34-36	cyclin D1	Homo sapiens	87-96
9745617-9	1998	TPA also strongly induced cyclin D1 expression in P+ (but not in P-) JB6 cells, but this induction started prior to the expression of cyclin A and cyclin B1.	Tetradecanoylphorbol Acetate	0-3	cyclin D1	Homo sapiens	26-35
9499444-4	1998	The correlation coefficient (r2) between doubling time (DT) and cyclin D1 in the 14 cell lines that doubled within 47.2 h was 0.4856, while the r2 between DT and cyclin dependent kinase 4 (CDK4) and that between DT and RB among those cell lines were 0.3761 and 0.0874, respectively.	Thymidine	56-58	cyclin D1	Homo sapiens	64-73
9485417-0	1998	A novel triplex-forming oligonucleotide targeted to human cyclin D1 (bcl-1, proto-oncogene) promoter inhibits transcription in HeLa cells.	triplex-forming oligonucleotide	8-39	cyclin D1	Homo sapiens	58-67
9521863-4	1998	Removal of NAC from the culture medium stimulates SMCs to synchronously reenter the cell cycle as judged by induction of cyclin D1 and B-myb gene expression during mid and late G1 phase, respectively, and induction of histone gene expression and [3H]thymidine incorporation during S phase.	Acetylcysteine	11-14	cyclin D1	Homo sapiens	121-130
9500441-7	1998	For this, MCF-7 cells stably transfected with a tet-inducible cyclin D1 expression vector were tested for their in vitro response to steroidal (ICI 182,780) and nonsteroidal (trans-4-hydroxytamoxifen) antiestrogens under condition of low (endogenous only) or high (exogenous) cyclin D1 levels.	tetramethylenedisulfotetramine	48-51	cyclin D1	Homo sapiens	62-71
9710718-2	1998	We studied the effects of cytotoxic concentrations of Taxol (TXL) on cyclin D1 and B1 expression on human ovarian cancer cell lines.	Paclitaxel	54-59	cyclin D1	Homo sapiens	69-78
9710718-2	1998	We studied the effects of cytotoxic concentrations of Taxol (TXL) on cyclin D1 and B1 expression on human ovarian cancer cell lines.	Paclitaxel	61-64	cyclin D1	Homo sapiens	69-78
10920963-5	1998	Immunohistochemical staining of cyclin D1 was performed using a streptavidin-biotin staining technique.	Biotin	77-83	cyclin D1	Homo sapiens	32-41
9485417-11	1998	This phosphorothioate modified TFO targeted to cyclin D1 also inhibits transcription of the cyclin D1 promoter in HeLa cells, as demonstrated by a decrease in luciferase expression from a stably integrated human cyclin D1 promoter driven luciferase construct.	Parathion	5-21	cyclin D1	Homo sapiens	92-101
9485417-11	1998	This phosphorothioate modified TFO targeted to cyclin D1 also inhibits transcription of the cyclin D1 promoter in HeLa cells, as demonstrated by a decrease in luciferase expression from a stably integrated human cyclin D1 promoter driven luciferase construct.	Parathion	5-21	cyclin D1	Homo sapiens	92-101
9485417-11	1998	This phosphorothioate modified TFO targeted to cyclin D1 also inhibits transcription of the cyclin D1 promoter in HeLa cells, as demonstrated by a decrease in luciferase expression from a stably integrated human cyclin D1 promoter driven luciferase construct.	tfo	31-34	cyclin D1	Homo sapiens	47-56
9485417-11	1998	This phosphorothioate modified TFO targeted to cyclin D1 also inhibits transcription of the cyclin D1 promoter in HeLa cells, as demonstrated by a decrease in luciferase expression from a stably integrated human cyclin D1 promoter driven luciferase construct.	tfo	31-34	cyclin D1	Homo sapiens	92-101
9485417-11	1998	This phosphorothioate modified TFO targeted to cyclin D1 also inhibits transcription of the cyclin D1 promoter in HeLa cells, as demonstrated by a decrease in luciferase expression from a stably integrated human cyclin D1 promoter driven luciferase construct.	tfo	31-34	cyclin D1	Homo sapiens	92-101
9489733-4	1998	In differentiated TR14 cells, okadaic acid increases the fraction of cells in the S phase, induces the appearance of cyclin B1 and cyclin D1 markers of the cell cycle, and triggers a time-dependent increase in DNA fragmentation after release of a thymidine block.	Okadaic Acid	30-42	cyclin D1	Homo sapiens	131-140
9485417-0	1998	A novel triplex-forming oligonucleotide targeted to human cyclin D1 (bcl-1, proto-oncogene) promoter inhibits transcription in HeLa cells.	triplex-forming oligonucleotide	8-39	cyclin D1	Homo sapiens	69-74
9485417-3	1998	The human cyclin D1 proto-oncogene promoter contains an 18-base pair purine-pyrimidine rich motif with three C.G interruptions.	purine	69-75	cyclin D1	Homo sapiens	10-19
9485417-3	1998	The human cyclin D1 proto-oncogene promoter contains an 18-base pair purine-pyrimidine rich motif with three C.G interruptions.	pyrimidine	76-86	cyclin D1	Homo sapiens	10-19
9485417-10	1998	Triplex formation by the cyclin D1 targeted phosphorothioate oligonucleotide occurs with a binding affinity approximately equal to that of phosphodiester oligonucleotides.	Phosphorothioate Oligonucleotides	44-76	cyclin D1	Homo sapiens	25-34
9485417-10	1998	Triplex formation by the cyclin D1 targeted phosphorothioate oligonucleotide occurs with a binding affinity approximately equal to that of phosphodiester oligonucleotides.	Oligonucleotides	154-170	cyclin D1	Homo sapiens	25-34
9485417-11	1998	This phosphorothioate modified TFO targeted to cyclin D1 also inhibits transcription of the cyclin D1 promoter in HeLa cells, as demonstrated by a decrease in luciferase expression from a stably integrated human cyclin D1 promoter driven luciferase construct.	Parathion	5-21	cyclin D1	Homo sapiens	47-56
9624417-5	1998	METHODS: Expression of the cyclin D1 and Rb genes was detected by standard immunnohistochemistry using paraffin wax embedded sections.	Paraffin	103-115	cyclin D1	Homo sapiens	27-36
9600126-1	1998	Previously, we demonstrated that inostamycin, an inhibitor of phosphatidylinositol turnover, caused cell cycle arrest at the G1 phase, inhibiting the expression of cyclins D1 and E in normal cells.	inostamycin	33-44	cyclin D1	Homo sapiens	164-180
9600126-4	1998	We found that inostamycin decreased cyclin D1, and increased cyclin-dependent kinase inhibitors such as p21WAF1 and p27KIP1 in Ms-1 cells.	inostamycin	14-25	cyclin D1	Homo sapiens	36-45
9485024-0	1998	Inhibition of cyclin D1 expression and phosphorylation of retinoblastoma protein by phosmidosine, a nucleotide antibiotic.	phosmidosine	84-96	cyclin D1	Homo sapiens	14-23
9485024-4	1998	However, phosmidosine inhibited hyperphosphorylation of retinoblastoma (RB) protein by RB-kinases such as cyclin-dependent kinase 4 and cyclin-dependent kinase 2, probably as a result of the inhibition of cyclin D1 expression.	phosmidosine	9-21	cyclin D1	Homo sapiens	205-214
9458362-0	1998	Retinoic acid suppresses insulin-induced cell growth and cyclin D1 gene expression in human breast cancer cells.	Tretinoin	0-13	cyclin D1	Homo sapiens	57-66
9458362-1	1998	We examined the effects of all-trans retinoic acid (RA) on the insulin-induced cell growth, cell cycle progression and cyclin D1 gene expression in breast cancer cells.	Tretinoin	52-54	cyclin D1	Homo sapiens	119-128
9458362-3	1998	The RA antagonism of insulin growth effect was associated with an inhibition of cell cycle progression and a suppression of insulin-induced cyclin D1 mRNA.	Tretinoin	4-6	cyclin D1	Homo sapiens	140-149
9458362-4	1998	The effect of RA on cyclin D1 mRNA was dose-dependent and was observed within 5 h of treatment when insulin response was maximal.	Tretinoin	14-16	cyclin D1	Homo sapiens	20-29
9427759-8	1998	This differential effect of D-type cyclins on v-Myb and c-Myb might help to explain the mechanism underlying the oncogenic activity of v-Myb, which appears to be a stronger transcriptional activator following the TPA-induced differentiation of transformed monoblasts when cyclin D1 and D2 are down-regulated.	Tetradecanoylphorbol Acetate	213-216	cyclin D1	Homo sapiens	272-281
9435306-0	1998	Inhibition of basal and mitogen-stimulated pancreatic cancer cell growth by cyclin D1 antisense is associated with loss of tumorigenicity and potentiation of cytotoxicity to cisplatinum.	Cisplatin	174-185	cyclin D1	Homo sapiens	76-85
9388270-5	1997	In contrast, all of the observed stimulatory effects of IGF-I on cell cycle progression, cyclin D1 synthesis, and pRb hyperphosphorylation were blocked by the specific phosphatidylinositol 3-kinase inhibitor LY294002, suggesting that phosphatidylinositol 3-kinase activity but not MAPK activity is required for transduction of the mitogenic IGF-I signal in MCF-7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-216	cyclin D1	Homo sapiens	89-98
9485199-7	1998	Peripheral blood mononuclear cells from HLA-A2-negative donors were stimulated with T2 cells presenting cyclin-D1-derived synthetic peptides.	Peptides	132-140	cyclin D1	Homo sapiens	104-113
9824849-0	1998	Monoterpenes inhibit cell growth, cell cycle progression, and cyclin D1 gene expression in human breast cancer cell lines.	Monoterpenes	0-12	cyclin D1	Homo sapiens	62-71
9824849-3	1998	In this study, we investigated the effects of limonene and limonene-related monoterpenes, perillyl alcohol and perillic acid, on cell growth, cell cycle progression, and expression of cyclin D1 cell cycle-regulatory gene in T-47D, MCF-7, and MDA-MB-231 breast cancer cell lines.	Limonene	46-54	cyclin D1	Homo sapiens	184-193
9824849-3	1998	In this study, we investigated the effects of limonene and limonene-related monoterpenes, perillyl alcohol and perillic acid, on cell growth, cell cycle progression, and expression of cyclin D1 cell cycle-regulatory gene in T-47D, MCF-7, and MDA-MB-231 breast cancer cell lines.	Limonene	59-67	cyclin D1	Homo sapiens	184-193
9824849-3	1998	In this study, we investigated the effects of limonene and limonene-related monoterpenes, perillyl alcohol and perillic acid, on cell growth, cell cycle progression, and expression of cyclin D1 cell cycle-regulatory gene in T-47D, MCF-7, and MDA-MB-231 breast cancer cell lines.	Monoterpenes	76-88	cyclin D1	Homo sapiens	184-193
9824849-3	1998	In this study, we investigated the effects of limonene and limonene-related monoterpenes, perillyl alcohol and perillic acid, on cell growth, cell cycle progression, and expression of cyclin D1 cell cycle-regulatory gene in T-47D, MCF-7, and MDA-MB-231 breast cancer cell lines.	perillyl alcohol	90-106	cyclin D1	Homo sapiens	184-193
9824849-3	1998	In this study, we investigated the effects of limonene and limonene-related monoterpenes, perillyl alcohol and perillic acid, on cell growth, cell cycle progression, and expression of cyclin D1 cell cycle-regulatory gene in T-47D, MCF-7, and MDA-MB-231 breast cancer cell lines.	perillic acid	111-124	cyclin D1	Homo sapiens	184-193
9824849-9	1998	Finally, we showed that the effects of limonene-related monoterpenes on cell proliferation and cell cycle progression were preceded by a decrease in cyclin D1 mRNA levels.	Limonene	39-47	cyclin D1	Homo sapiens	149-158
9824849-9	1998	Finally, we showed that the effects of limonene-related monoterpenes on cell proliferation and cell cycle progression were preceded by a decrease in cyclin D1 mRNA levels.	Monoterpenes	56-68	cyclin D1	Homo sapiens	149-158
9310957-0	1997	Cyclin D1 protein in multiple myeloma and plasmacytoma: an immunohistochemical study using fixed, paraffin-embedded tissue sections.	Paraffin	98-106	cyclin D1	Homo sapiens	0-9
9388487-4	1997	Although both cyclin D1- and cyclin-E-dependent kinases are active in the late G1 phase in human fibroblasts, cyclin E/Cdk2 specifically phosphorylates p27 on threonine-187 in vitro.	Threonine	159-168	cyclin D1	Homo sapiens	14-23
9342364-0	1997	Posttranslational regulation of cyclin D1 by retinoic acid: a chemoprevention mechanism.	Tretinoin	45-58	cyclin D1	Homo sapiens	32-41
9342364-5	1997	Exogenous cyclin D1 protein also declined after RA treatment of transfected, immortalized human bronchial epithelial cells, suggesting that posttranslational mechanisms were active in this regulation of cyclin D1 expression.	Tretinoin	48-50	cyclin D1	Homo sapiens	10-19
9342364-6	1997	Findings were extended by showing treatment with ubiquitin-dependent proteasome inhibitors: calpain inhibitor I and lactacystin each prevented this decreased cyclin D1 protein expression, despite RA treatment.	lactacystin	116-127	cyclin D1	Homo sapiens	158-167
9342364-11	1997	Notably, this RA-signaled cyclin D1 proteolysis depended on the C-terminal PEST sequence, a region rich in proline (P), glutamate (E), serine (S), and threonine (T).	Proline	107-114	cyclin D1	Homo sapiens	26-35
9342364-11	1997	Notably, this RA-signaled cyclin D1 proteolysis depended on the C-terminal PEST sequence, a region rich in proline (P), glutamate (E), serine (S), and threonine (T).	Glutamic Acid	120-129	cyclin D1	Homo sapiens	26-35
9342364-11	1997	Notably, this RA-signaled cyclin D1 proteolysis depended on the C-terminal PEST sequence, a region rich in proline (P), glutamate (E), serine (S), and threonine (T).	Serine	135-141	cyclin D1	Homo sapiens	26-35
9342364-11	1997	Notably, this RA-signaled cyclin D1 proteolysis depended on the C-terminal PEST sequence, a region rich in proline (P), glutamate (E), serine (S), and threonine (T).	Threonine	151-160	cyclin D1	Homo sapiens	26-35
9417875-2	1997	About 20% of the total cellular levels of cyclin D1 was found to be tightly bound to nuclear structures, being the complex formation resistant to DNase I treatment and to high salt extraction.	Salts	176-180	cyclin D1	Homo sapiens	42-51
9417875-4	1997	Cell fractionation and immunoprecipitation techniques after in vivo 32P-labeling showed that both soluble and nuclear-bound forms of cyclin D1 were phosphorylated.	Phosphorus-32	68-71	cyclin D1	Homo sapiens	133-142
9417875-6	1997	Treatment with the protein kinase inhibitor staurosporine, which induces a cell cycle arrest in early G1 phase, strongly reduced cyclin D1 phosphorylation.	Staurosporine	44-57	cyclin D1	Homo sapiens	129-138
9271411-2	1997	We show that ectopic expression of cyclin D1 can stimulate the transcriptional activity of the estrogen receptor in the absence of estradiol and that this activity can be inhibited by 4-hydroxytamoxifen and ICI 182,780.	Estradiol	131-140	cyclin D1	Homo sapiens	35-44
9271411-2	1997	We show that ectopic expression of cyclin D1 can stimulate the transcriptional activity of the estrogen receptor in the absence of estradiol and that this activity can be inhibited by 4-hydroxytamoxifen and ICI 182,780.	hydroxytamoxifen	184-202	cyclin D1	Homo sapiens	35-44
9271411-2	1997	We show that ectopic expression of cyclin D1 can stimulate the transcriptional activity of the estrogen receptor in the absence of estradiol and that this activity can be inhibited by 4-hydroxytamoxifen and ICI 182,780.	ici	207-210	cyclin D1	Homo sapiens	35-44
9310957-1	1997	In this study, we analyzed 69 plasma cell neoplasms, including 54 multiple myelomas (MMs), 3 cases of plasma cell leukemia, and 12 plasmacytomas, for expression of cyclin D1 protein using an immuno-histochemical method applied to routinely fixed, paraffin-embedded tissue sections.	Paraffin	247-255	cyclin D1	Homo sapiens	164-173
9258408-0	1997	G1 phase arrest of human smooth muscle cells by heparin, IL-4 and cAMP is linked to repression of cyclin D1 and cdk2.	Heparin	48-55	cyclin D1	Homo sapiens	98-107
9258408-0	1997	G1 phase arrest of human smooth muscle cells by heparin, IL-4 and cAMP is linked to repression of cyclin D1 and cdk2.	Cyclic AMP	66-70	cyclin D1	Homo sapiens	98-107
9258408-6	1997	Heparin, a strong inhibitor of HUASMC proliferation, strongly down-modulated the levels of cyclin D1 mRNA and protein, cdk2 mRNA and cdc2 protein.	Heparin	0-7	cyclin D1	Homo sapiens	91-100
9267824-10	1997	We conclude that staining formalin-fixed, paraffin-embedded, high-grade lymphomas with anti-cyclin D-1 antibody is useful in confirming the diagnosis of MCL-BV, whereas positive reactions with CD99, CD34, and particularly TdT are more characteristic of LBL.	Formaldehyde	26-34	cyclin D1	Homo sapiens	92-102
9342842-6	1997	Interestingly, 9-cis-RA temporarily increased the amount of the cyclin dependent kinase (cdk) inhibitor, Waf1/Cip1/Sdi1/p21 protein, and also reduced the amount of cdk-7, epidermal growth factor receptor (EGFR) and cyclin D1 proteins, followed by reduction in phosphorylation of the product of the retinoblastoma tumor suppressor gene (Rb) in the sensitive TMK-1 cells, but not in the resistant MKN-7 cells.	Alitretinoin	15-23	cyclin D1	Homo sapiens	215-224
9233783-4	1997	We report that 9-cis retinoic acid (9-cis RA) and all trans retinoic acid (tRA) inhibited the cyclin D1 and D3 expression levels of human MCF-7, ZR-75 and T-47D breast carcinoma cells in vitro.	Alitretinoin	15-34	cyclin D1	Homo sapiens	94-103
9233783-4	1997	We report that 9-cis retinoic acid (9-cis RA) and all trans retinoic acid (tRA) inhibited the cyclin D1 and D3 expression levels of human MCF-7, ZR-75 and T-47D breast carcinoma cells in vitro.	Radium	42-44	cyclin D1	Homo sapiens	94-103
9233783-4	1997	We report that 9-cis retinoic acid (9-cis RA) and all trans retinoic acid (tRA) inhibited the cyclin D1 and D3 expression levels of human MCF-7, ZR-75 and T-47D breast carcinoma cells in vitro.	Tretinoin	21-34	cyclin D1	Homo sapiens	94-103
9233783-4	1997	We report that 9-cis retinoic acid (9-cis RA) and all trans retinoic acid (tRA) inhibited the cyclin D1 and D3 expression levels of human MCF-7, ZR-75 and T-47D breast carcinoma cells in vitro.	Tretinoin	75-78	cyclin D1	Homo sapiens	94-103
9199341-4	1997	These results support the notion that cyclin D1 has an important role in steroid-dependent cell proliferation and that estrogen, by regulating the activities of G1 cyclin-dependent kinases, can control the proliferation of breast cancer cells.	Steroids	73-80	cyclin D1	Homo sapiens	38-47
9282199-2	1997	Overexpression of cyclin D1 was detected immunohistochemically using DCS6 monoclonal antibody on formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	97-105	cyclin D1	Homo sapiens	18-27
9282199-2	1997	Overexpression of cyclin D1 was detected immunohistochemically using DCS6 monoclonal antibody on formalin-fixed, paraffin-embedded tissue sections.	Paraffin	113-121	cyclin D1	Homo sapiens	18-27
9199341-2	1997	Addition of estradiol relieves the cell cycle block created by tamoxifen treatment, leading to marked activation of cyclin E-cdk2 complexes and phosphorylation of the retinoblastoma protein within 6 h. Cyclin D1 levels increase significantly while the levels of cyclin E, cdk2, and the p21 and p27 cdk inhibitors are relatively constant.	Estradiol	12-21	cyclin D1	Homo sapiens	202-211
9199341-2	1997	Addition of estradiol relieves the cell cycle block created by tamoxifen treatment, leading to marked activation of cyclin E-cdk2 complexes and phosphorylation of the retinoblastoma protein within 6 h. Cyclin D1 levels increase significantly while the levels of cyclin E, cdk2, and the p21 and p27 cdk inhibitors are relatively constant.	Tamoxifen	63-72	cyclin D1	Homo sapiens	202-211
9185997-7	1997	Expression of cyclin D1, cyclin-dependent kinase 4, and cyclin E proteins, however, decreased in association with RA-mediated G1 arrest.	Tretinoin	114-116	cyclin D1	Homo sapiens	14-23
9186003-4	1997	We show here that cisplatin-treated mammalian cells accumulate normal levels of cyclin D1 and cyclin E but fail to produce cyclin A.	Cisplatin	18-27	cyclin D1	Homo sapiens	80-89
9815758-4	1997	We addressed this question in vitro by testing the ability of ectopic cyclin D1 overexpression to overcome the growth-inhibitory effects of tamoxifen and the pure steroidal antiestrogens, ICI 164384 and ICI 182780, in T-47D and MCF-7 human breast cancer cells.	Tamoxifen	140-149	cyclin D1	Homo sapiens	70-79
9815758-5	1997	In cells stably transfected with a human cyclin D1 cDNA under the control of a metal-inducible metallothionein promoter, cyclin D1 expression was increased 2-4-fold following treatment with zinc.	Metals	79-84	cyclin D1	Homo sapiens	41-50
9815758-5	1997	In cells stably transfected with a human cyclin D1 cDNA under the control of a metal-inducible metallothionein promoter, cyclin D1 expression was increased 2-4-fold following treatment with zinc.	Metals	79-84	cyclin D1	Homo sapiens	121-130
9191053-2	1997	To address the relationship between cyclin D1 and other cell cycle regulatory proteins, we established human glioma and rodent fibroblast cell lines in which cyclin D1 expression could be regulated ectopically with tetracycline.	Tetracycline	215-227	cyclin D1	Homo sapiens	158-167
9154827-6	1997	In in vitro assays, upstream sequence-dependent transcription from the human cyclin D1 promoter was significantly reduced in ts13 nuclear extracts preincubated at 30 degrees C but not in similarly treated BHK nuclear extracts, and transcription in the ts13 extract was restored by addition of an affinity-purified human TFIID.	(2R)-2-benzyl-5-hydroxy-4-oxopentanoic acid	205-208	cyclin D1	Homo sapiens	77-86
9139732-5	1997	We demonstrate that phosphorylation by either CDK2-cyclin A, which phosphorylates T821, or CDK4-cyclin D1, which phosphorylates threonine 826, can disable pRB for subsequent binding of an LXCXE protein.	Threonine	128-137	cyclin D1	Homo sapiens	96-105
9001421-10	1997	These studies show that Rb interaction with E2F1 is regulated by cdk4 and cyclin D1 within p210 BCR-ABL transformed leukemia cells in early G1 phase of the cell cycle.	Rubidium	24-26	cyclin D1	Homo sapiens	74-83
9168007-4	1997	Genistein and the fungal toxin zearalenone were found to increase the activity of cyclin dependent kinase 2 (Cdk2) and cyclin D1 synthesis and stimulate the hyperphosphorylation of the retinoblastoma susceptibility gene product pRb105 in MCF-7 cells.	Genistein	0-9	cyclin D1	Homo sapiens	119-128
9168007-4	1997	Genistein and the fungal toxin zearalenone were found to increase the activity of cyclin dependent kinase 2 (Cdk2) and cyclin D1 synthesis and stimulate the hyperphosphorylation of the retinoblastoma susceptibility gene product pRb105 in MCF-7 cells.	Zearalenone	31-42	cyclin D1	Homo sapiens	119-128
9209449-3	1997	In the present study, we have immunohistochemically examined the cyclin D1 protein in a large series of 315 malignant lymphomas including 39 MCLs on paraffin sections.	Paraffin	149-157	cyclin D1	Homo sapiens	65-74
9049186-11	1997	Cyclin D1 protein synthesis was increased by DDT and estradiol in MCF-7 cells.	DDT	45-48	cyclin D1	Homo sapiens	0-9
9049186-11	1997	Cyclin D1 protein synthesis was increased by DDT and estradiol in MCF-7 cells.	Estradiol	53-62	cyclin D1	Homo sapiens	0-9
9010227-5	1997	We provide evidence that this residue, serine 608 of pRB, is an authentic phosphorylation site that can be phosphorylated in vitro by cyclin A-CDK2 and cyclin D1-CDK4 kinases but not by cyclin E-CDK2 kinase or the mitogen activated kinase ERK2.	Serine	39-45	cyclin D1	Homo sapiens	152-161
9218727-0	1997	Gossypol inhibition of mitosis, cyclin D1 and Rb protein in human mammary cancer cells and cyclin-D1 transfected human fibrosarcoma cells.	Gossypol	0-8	cyclin D1	Homo sapiens	32-41
9218727-3	1997	Western blot analysis using anti-human Rb antibodies and anti-human cyclin D1 antibodies in MCF-7 cells and high- and low-expression cyclin D1-transfected fibrosarcoma cells indicated that, after 6 h exposure, gossypol decreased the expression levels of these proteins in a dose-dependent manner.	Gossypol	210-218	cyclin D1	Homo sapiens	68-77
9218727-3	1997	Western blot analysis using anti-human Rb antibodies and anti-human cyclin D1 antibodies in MCF-7 cells and high- and low-expression cyclin D1-transfected fibrosarcoma cells indicated that, after 6 h exposure, gossypol decreased the expression levels of these proteins in a dose-dependent manner.	Gossypol	210-218	cyclin D1	Homo sapiens	133-142
9218727-5	1997	Gossypol (10 microM) treated also decreased cyclin D1-associated kinase activity on histone H1 used as a substrate in MCF-7 cells.	Gossypol	0-8	cyclin D1	Homo sapiens	44-53
9218727-6	1997	These results suggest that gossypol might suppress growth by modulating the expression of cell cycle regulatory proteins Rb and cyclin D1 and the phosphorylation of Rb protein.	Gossypol	27-35	cyclin D1	Homo sapiens	128-137
9099745-11	1997	These results provide an explanation for the early activation of both cyclin D1-Cdk4 and cyclin E-Cdk2 complexes that accompany G1-S phase progression in response to estradiol.	Estradiol	166-175	cyclin D1	Homo sapiens	70-79
9178843-11	1997	Further experimental approaches arise from antisense oligonucleotides or ribozymes blocking the overexpression of bcl-1 especially in this lymphoma entity.	Oligonucleotides	53-69	cyclin D1	Homo sapiens	114-119
8988060-7	1997	Increased expression of cyclin D1 and Cdk4 in adenomas was accompanied by a significantly increased 5-bromo-2"-deoxyuridine incorporation rate in the same areas.	Bromodeoxyuridine	100-123	cyclin D1	Homo sapiens	24-33
9001421-0	1997	Cyclic AMP negatively controls c-myc transcription and G1 cell cycle progression in p210 BCR-ABL transformed cells: inhibitory activity exerted through cyclin D1 and cdk4.	Cyclic AMP	0-10	cyclin D1	Homo sapiens	152-161
9001421-5	1997	In p210 BCR-ABL transformed cells transiting early G1 phase, treatment with a cAMP analogue led to inhibition of cyclin D1 synthesis, and marked reduction of cdk4 kinase activity.	Cyclic AMP	78-82	cyclin D1	Homo sapiens	113-122
9001421-11	1997	In this context, both cyclin D1 and cdk4 are subject to the level of intracellular cAMP.	Cyclic AMP	83-87	cyclin D1	Homo sapiens	22-31
8954100-0	1996	Direct inhibition of the expression of cyclin D1 gene by sodium butyrate.	Butyric Acid	57-72	cyclin D1	Homo sapiens	39-48
21590003-4	1997	Consistent with a G1 arrest, MDL 27695 significantly reduced estradiol-mediated increase in the expression of cyclin D1.	Estradiol	61-70	cyclin D1	Homo sapiens	110-119
9000144-0	1996	Glucose-regulated stresses cause decreased expression of cyclin D1 and hypophosphorylation of retinoblastoma protein in human cancer cells.	Glucose	0-7	cyclin D1	Homo sapiens	57-66
8981358-11	1997	Conversely, cyclin D1-rescued cells were inhibited from forming CSF-1-dependent colonies in agar when challenged with either a dominant-negative c-myc mutant or mad, a transcription factor which competes with myc for max, its requisite heterodimeric partner.	Agar	92-96	cyclin D1	Homo sapiens	12-21
9003781-3	1996	We found that the consensus amino acid sequence for phosphorylation by cyclin D1-Cdk4 is different from S/T-P-X-K/R, which is the consensus sequence for phosphorylation by cyclin A/E-Cdk2 using various synthetic peptides as substrates.	Peptides	212-220	cyclin D1	Homo sapiens	71-80
8954100-1	1996	In the mouse fibroblasts BP-A31 as well as in the human epidermoid carcinoma cells KB-3-1, both cyclin D1 mRNA and protein contents decreased rapidly during incubation with sodium butyrate.	Butyric Acid	173-188	cyclin D1	Homo sapiens	96-105
8954100-4	1996	An 11 base-pair segment situated within this region, with a strong homology to the butyrate-response consensus element identified in butyrate-inducible promoters, also caused an inhibition of transcription under these conditions, indicating that cyclin D1 expression is inhibited by butyrate at the transcriptional level.	Butyrates	83-91	cyclin D1	Homo sapiens	246-255
8954100-4	1996	An 11 base-pair segment situated within this region, with a strong homology to the butyrate-response consensus element identified in butyrate-inducible promoters, also caused an inhibition of transcription under these conditions, indicating that cyclin D1 expression is inhibited by butyrate at the transcriptional level.	Butyrates	133-141	cyclin D1	Homo sapiens	246-255
8954100-4	1996	An 11 base-pair segment situated within this region, with a strong homology to the butyrate-response consensus element identified in butyrate-inducible promoters, also caused an inhibition of transcription under these conditions, indicating that cyclin D1 expression is inhibited by butyrate at the transcriptional level.	Butyrates	133-141	cyclin D1	Homo sapiens	246-255
8990623-0	1996	Herbimycin A down-regulates messages of cyclin D1 and c-myc during erythroid differentiation of K562 cells.	herbimycin	0-12	cyclin D1	Homo sapiens	40-49
8990623-8	1996	Cyclin D1 was initially down-regulated to an undetectable level at 6 h, although its expression recovered gradually from 12 h and returned to baseline at 24 h. c-myc was also down-regulated from 1 h to 6 h. These data suggest that signals originating from bcr-abl kinase are at least partly transduced through both c-myc and cyclin D1, and that herbimycin A-induced erythroid differentiation occurs during or after the cessation of growth due to interference with these signals.	herbimycin	345-357	cyclin D1	Homo sapiens	0-9
8797766-14	1996	Two cell clones expressed high levels of cyclin D1 mRNA and protein as compared with control cells transfected with plasmids containing the neomycin-resistance gene only.	Neomycin	140-148	cyclin D1	Homo sapiens	41-50
8943347-4	1996	Combined microinjection and biochemical approaches showed that whereas these three mitogenic cascades are sensitive to the p16 inhibitor of cdk4/6 and/or cyclin D1-neutralizing antibody and able to induce pRb kinase activity, their upstream biochemical routes are distinct as demonstrated by their differential sensitivity to lovastatin and requirements for mitogen-activated protein kinases whose sustained activation is seen only in the growth factor-dependent pathway.	Lovastatin	326-336	cyclin D1	Homo sapiens	154-163
9014860-0	1996	Cyclin D1 overexpression in non-small cell lung carcinoma: correlation with Ki67 labelling index and poor cytoplasmic differentiation.	ki67	76-80	cyclin D1	Homo sapiens	0-9
8797766-18	1996	Cytotoxicity assays revealed a statistically significant (P &lt; .01) increase in resistance to methotrexate in cells expressing high levels of cyclin D1 compared with cells expressing lower levels.	Methotrexate	96-108	cyclin D1	Homo sapiens	144-153
8797766-24	1996	Tumors with overexpression of cyclin D1 may be relatively refractory to methotrexate treatment.	Methotrexate	72-84	cyclin D1	Homo sapiens	30-39
8764748-4	1996	In the present study, we immunohistochemically investigated the PRAD1/cyclin D1 protein in a large series of 334 lymphoproliferative disorders, including 39 cases of MCLs on paraffin sections.	Paraffin	174-182	cyclin D1	Homo sapiens	64-69
8702807-15	1996	Furthermore, inhibition of p38(MAPK) activity with the specific inhibitor, SB203580, enhanced cyclin D1 transcription and protein level.	SB 203580	75-83	cyclin D1	Homo sapiens	94-103
8650198-6	1996	In both the pRB+ and pRB- cells, cyclin D1-associated kinase activities were reduced on staurosporine treatment.	Staurosporine	88-101	cyclin D1	Homo sapiens	33-42
8760301-3	1996	We report that 8-bromo-cAMP (8Br-cAMP) and lipopolysaccharide (LPS) potently reduced CSF-1-stimulated cyclin D1 protein, and cyclin-dependent kinase (cdk) 4 mRNA and protein levels, while the inhibitory effects of the Na+/ H+ antiport inhibitor 5-(N",N"-dimethyl) amiloride (DMA) and interferon gamma (IFN gamma ) were only weak.	8-Bromo Cyclic Adenosine Monophosphate	15-27	cyclin D1	Homo sapiens	102-111
8760301-3	1996	We report that 8-bromo-cAMP (8Br-cAMP) and lipopolysaccharide (LPS) potently reduced CSF-1-stimulated cyclin D1 protein, and cyclin-dependent kinase (cdk) 4 mRNA and protein levels, while the inhibitory effects of the Na+/ H+ antiport inhibitor 5-(N",N"-dimethyl) amiloride (DMA) and interferon gamma (IFN gamma ) were only weak.	8-Bromo Cyclic Adenosine Monophosphate	29-37	cyclin D1	Homo sapiens	102-111
8674031-3	1996	Recombinant CDK4-cyclin D1 was inhibited potently by Flavopiridol (Kiapp, 65 nM), competitive with respect to ATP.	alvocidib	53-65	cyclin D1	Homo sapiens	17-26
8674031-3	1996	Recombinant CDK4-cyclin D1 was inhibited potently by Flavopiridol (Kiapp, 65 nM), competitive with respect to ATP.	kiapp	67-72	cyclin D1	Homo sapiens	17-26
8674031-3	1996	Recombinant CDK4-cyclin D1 was inhibited potently by Flavopiridol (Kiapp, 65 nM), competitive with respect to ATP.	Adenosine Triphosphate	110-113	cyclin D1	Homo sapiens	17-26
8760592-0	1996	Sensitivity to cis-diamminedichloroplatinum in human cancer cells is related to expression of cyclin D1 but not c-raf-1 protein.	Cisplatin	15-43	cyclin D1	Homo sapiens	94-103
8760592-8	1996	We report that in the 16 human cell lines which we have studied, high cyclin D1 expression is related to CDDP resistance but has no relationship with radiation responsiveness, whereas high c-raf-1 expression, although related to radiosensitivity has no relationship with CDDP responsiveness.	Cisplatin	105-109	cyclin D1	Homo sapiens	70-79
8668202-5	1996	The remaining two mutations, a G-to-W mutation at position 101 (Gl01W) and V126D, both of which are associated with familial melanoma, were found to be temperature sensitive for binding to Cdk4 and Cdk6 in vitro, for inhibiting cyclin D1-Cdk4 in a reconstituted pRb-kinase assay, and for increasing the proportion of G1-phase cells following transfection.	gl01w	64-69	cyclin D1	Homo sapiens	228-237
8649771-0	1996	17beta-Estradiol induces cyclin D1 gene transcription, p36D1-p34cdk4 complex activation and p105Rb phosphorylation during mitogenic stimulation of G(1)-arrested human breast cancer cells.	Estradiol	0-16	cyclin D1	Homo sapiens	25-34
8604811-8	1996	Two MC cases studied by Southern blotting exhibited rearrangement of the bcl-1 locus.	Methylcholanthrene	4-6	cyclin D1	Homo sapiens	73-78
8635520-6	1996	The expression of cdk2 and cyclin D1 in the quiescent cells was reduced after stimulation by renewal of the medium and then increased, accompanied by Rb phosphorylation and cdc2 expression around the G1/S transition.	Rubidium	150-152	cyclin D1	Homo sapiens	27-36
8608989-1	1996	We have used immunohistochemical staining to assess the expression of cyclin D1 in formalin-fixed sections of 345 breast carcinomas, dating back 20 years.	Formaldehyde	83-91	cyclin D1	Homo sapiens	70-79
8623758-0	1996	Detection of the bcl-1 rearrangement at the major translocation cluster in frozen and paraffin-embedded tissues of mantle cell lymphomas by polymerase chain reaction.	Paraffin	86-94	cyclin D1	Homo sapiens	17-22
8713673-4	1996	Variation at the glucocorticoid receptor locus can be identified as a biallelic restriction fragment length polymorphism (Bcl1); subjects with contrasting genotypes show altered skin vasoconstrictor responses to topically applied budesonide without any significant change in leucocyte receptor binding characteristics.	Budesonide	230-240	cyclin D1	Homo sapiens	122-126
8622677-2	1996	Here we demonstrate that treatment of breast carcinoma MCF-7 cells with PGA2 leads to G1 arrest associated with a dramatic decrease in the levels of cyclin D1 and cyclin-dependent kinase 4 (cdk4) and accompanied by an increase in the expression of p21.	prostaglandin A2	72-76	cyclin D1	Homo sapiens	149-158
10887489-2	1996	Cyclin D1 is necessary, rate-limiting and sufficient for G1 progression in breast cancer cells and regulation of cyclin D1 expression or function is an early response to steroid and steroid antagonist regulation of proliferation.	Steroids	170-177	cyclin D1	Homo sapiens	113-122
10887489-2	1996	Cyclin D1 is necessary, rate-limiting and sufficient for G1 progression in breast cancer cells and regulation of cyclin D1 expression or function is an early response to steroid and steroid antagonist regulation of proliferation.	Steroids	182-189	cyclin D1	Homo sapiens	0-9
10887489-2	1996	Cyclin D1 is necessary, rate-limiting and sufficient for G1 progression in breast cancer cells and regulation of cyclin D1 expression or function is an early response to steroid and steroid antagonist regulation of proliferation.	Steroids	182-189	cyclin D1	Homo sapiens	113-122
8607831-5	1996	More strikingly, we found that different cyclin D1 antisense oligodeoxynucleotides exert different efficacy on the inhibition of cell growth and gene expression.	Oligodeoxyribonucleotides	61-82	cyclin D1	Homo sapiens	41-50
8608874-1	1996	BACKGROUND &amp; AIMS: Cyclin D1 gene amplification and/or overexpression occurs in several human cancers.	Adenosine Monophosphate	12-15	cyclin D1	Homo sapiens	23-32
8740788-4	1996	Recent studies showed that overexpression of the cyclin D1 protein can be easily detected by immunohistochemistry (IHC) on formalin-fixed, paraffin embedded tissues.	Formaldehyde	123-131	cyclin D1	Homo sapiens	49-58
8740788-4	1996	Recent studies showed that overexpression of the cyclin D1 protein can be easily detected by immunohistochemistry (IHC) on formalin-fixed, paraffin embedded tissues.	Paraffin	139-147	cyclin D1	Homo sapiens	49-58
8611372-3	1996	After affinity purification, the antiserum specifically detected overexpression of cyclin D1 in formalin-fixed, paraffin-embedded tumour material also.	Formaldehyde	96-104	cyclin D1	Homo sapiens	83-92
8611372-3	1996	After affinity purification, the antiserum specifically detected overexpression of cyclin D1 in formalin-fixed, paraffin-embedded tumour material also.	Paraffin	112-120	cyclin D1	Homo sapiens	83-92
8526214-0	1995	Detection of bcl-1 gene rearrangement and B-cell clonality in mantle cell lymphoma using formalin-fixed, paraffin-embedded tissues.	Formaldehyde	89-97	cyclin D1	Homo sapiens	13-18
8573118-0	1996	Association of cyclin-dependent kinase-4 and cyclin D1 in neonatal beta cells after mitogenic stimulation by lysophosphatidic acid.	lysophosphatidic acid	109-130	cyclin D1	Homo sapiens	45-54
8595156-2	1996	The differentiation inducer sodium butyrate (NaB) arrested growth of N.1 ovarian carcinoma cells and repressed expression of cyclin D1/prad1 and the invasiveness-related protease plasminogen activator-urokinase (plau).	Butyric Acid	28-43	cyclin D1	Homo sapiens	125-134
8595156-2	1996	The differentiation inducer sodium butyrate (NaB) arrested growth of N.1 ovarian carcinoma cells and repressed expression of cyclin D1/prad1 and the invasiveness-related protease plasminogen activator-urokinase (plau).	Butyric Acid	28-43	cyclin D1	Homo sapiens	135-140
8595156-2	1996	The differentiation inducer sodium butyrate (NaB) arrested growth of N.1 ovarian carcinoma cells and repressed expression of cyclin D1/prad1 and the invasiveness-related protease plasminogen activator-urokinase (plau).	nab	45-48	cyclin D1	Homo sapiens	125-134
8595156-2	1996	The differentiation inducer sodium butyrate (NaB) arrested growth of N.1 ovarian carcinoma cells and repressed expression of cyclin D1/prad1 and the invasiveness-related protease plasminogen activator-urokinase (plau).	nab	45-48	cyclin D1	Homo sapiens	135-140
8595156-6	1996	We wanted to investigate NaB-mediated interference on signals contributing to the expression on prad1, plau and growth arrest-specific 6 (gas6).	nab	25-28	cyclin D1	Homo sapiens	96-101
8526214-0	1995	Detection of bcl-1 gene rearrangement and B-cell clonality in mantle cell lymphoma using formalin-fixed, paraffin-embedded tissues.	Paraffin	105-113	cyclin D1	Homo sapiens	13-18
8526214-10	1995	We have demonstrated that MTC bcl-1 gene rearrangements can be amplified from formalin-fixed tissue.	Formaldehyde	78-86	cyclin D1	Homo sapiens	30-35
8526214-12	1995	With specialized nucleic acid isolation techniques and appropriate PCR protocol design, formalin-fixed, paraffin-embedded tissue is an adequate source of DNA for assessing MTC bcl-1 and IgH gene rearrangements.	Formaldehyde	88-96	cyclin D1	Homo sapiens	176-181
8526214-12	1995	With specialized nucleic acid isolation techniques and appropriate PCR protocol design, formalin-fixed, paraffin-embedded tissue is an adequate source of DNA for assessing MTC bcl-1 and IgH gene rearrangements.	Paraffin	104-112	cyclin D1	Homo sapiens	176-181
7589260-8	1995	Treatment with TPA during G1 caused a three to four fold increase in cyclin D1 mRNA expression, but blocked the increase in the expression of cyclin A and cyclin B mRNAs later in the cell cycle.	Tetradecanoylphorbol Acetate	15-18	cyclin D1	Homo sapiens	69-78
7585469-3	1995	Estrogen-depletion and treatment with tamoxifen effectively induced a G1-arrest in both cell lines, accompanied by a decrease of the mRNA levels of histone H4, cyclin A, cyclin D1, and c-myc.	Tamoxifen	38-47	cyclin D1	Homo sapiens	170-179
7589260-9	1995	TPA caused a small increase in levels of cyclin D1 and had little effect on cyclin E, suggesting these G1 cyclins were not limiting.	Tetradecanoylphorbol Acetate	0-3	cyclin D1	Homo sapiens	41-50
7590706-4	1995	In this study, polymerase chain reaction (PCR) and Southern blot analysis were used to show the presence of JH/bcl-1 translocation in a typical case of LP of the gastrointestinal tract.	leucylproline	152-154	cyclin D1	Homo sapiens	111-116
7735555-7	1995	Sequential hybridization of the PCR products with oligonucleotide probes 3" to the bcl-1 MTC primer revealed that the breakpoints in the bcl-1 MTC were clustered around an Sst I restriction site over a range of 170 base pairs.	Oligonucleotides	50-65	cyclin D1	Homo sapiens	137-142
7559524-3	1995	The present study demonstrates that transforming mutants of p21ras (Ras Val-12, Ras Leu-61) induce the cyclin D1 promoter in human trophoblasts (JEG-3), mink lung epithelial (Mv1.Lu), and in Chinese hamster ovary fibroblast cell lines.	Valine	72-75	cyclin D1	Homo sapiens	103-112
7559524-3	1995	The present study demonstrates that transforming mutants of p21ras (Ras Val-12, Ras Leu-61) induce the cyclin D1 promoter in human trophoblasts (JEG-3), mink lung epithelial (Mv1.Lu), and in Chinese hamster ovary fibroblast cell lines.	Leucine	84-87	cyclin D1	Homo sapiens	103-112
7559524-8	1995	Expression of plasmids encoding either dominant negative MAPK (p41MAPKi) or dominant negatives of ETS activation (Ets-LacZ), antagonized MAPK-dependent induction of cyclin D1 promoter activity.	ets-lacz	114-122	cyclin D1	Homo sapiens	165-174
7670110-5	1995	We developed an immunohistochemical assay to detect overexpression of the cyclin D1 protein on conventional formalin-fixed, paraffin-embedded biopsies using the well-defined monoclonal antibody DCS-6.	Formaldehyde	108-116	cyclin D1	Homo sapiens	74-83
7670110-5	1995	We developed an immunohistochemical assay to detect overexpression of the cyclin D1 protein on conventional formalin-fixed, paraffin-embedded biopsies using the well-defined monoclonal antibody DCS-6.	Paraffin	124-132	cyclin D1	Homo sapiens	74-83
7670110-13	1995	Detection of cyclin D1 overexpression on formalin-fixed, paraffin-embedded tissues using the DCS-6 monoclonal antibody can be applied for routine diagnostic purposes.	Formaldehyde	41-49	cyclin D1	Homo sapiens	13-22
7670110-13	1995	Detection of cyclin D1 overexpression on formalin-fixed, paraffin-embedded tissues using the DCS-6 monoclonal antibody can be applied for routine diagnostic purposes.	Paraffin	57-65	cyclin D1	Homo sapiens	13-22
7540362-3	1995	In a previous study, the authors demonstrated expression of cyclin D1 in 15 of 15 cases of mantle cell lymphoma and 1 of 8 cases of B-chronic lymphocytic leukemia (B-CLL) using a polyclonal antibody and microwave enhanced immunohistochemical staining method on paraffin-embedded tissue sections.	Paraffin	261-269	cyclin D1	Homo sapiens	60-69
7747810-5	1995	We then attempted to correlate overexpression of cyclin D1 antigen and prognosis, by using 55 formalin-fixed, paraffin-embedded specimens of esophageal cancer.	Formaldehyde	94-102	cyclin D1	Homo sapiens	49-58
7739541-4	1995	Antibody-mediated neutralization of cyclin D1 arrested the RB-positive ME and SKUT1B cells in G1, whereas this cyclin appeared dispensable in the RB-deficient ME and SKUT1A cells.	methionylglutamic acid	71-73	cyclin D1	Homo sapiens	36-45
7867006-2	1995	Overexpression of cyclin D1 was detected immunohistochemically using an affinity-purified polyclonal antibody directed against the carboxyl-terminal part of the cyclin D1 protein, applied to formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	191-199	cyclin D1	Homo sapiens	18-27
7867006-2	1995	Overexpression of cyclin D1 was detected immunohistochemically using an affinity-purified polyclonal antibody directed against the carboxyl-terminal part of the cyclin D1 protein, applied to formalin-fixed, paraffin-embedded tissue sections.	Formaldehyde	191-199	cyclin D1	Homo sapiens	161-170
7867006-2	1995	Overexpression of cyclin D1 was detected immunohistochemically using an affinity-purified polyclonal antibody directed against the carboxyl-terminal part of the cyclin D1 protein, applied to formalin-fixed, paraffin-embedded tissue sections.	Paraffin	207-215	cyclin D1	Homo sapiens	18-27
7664838-0	1995	CDK4/cyclin D1/PCNA complexes during staurosporine-induced G1 arrest and G0 arrest of human fibroblasts.	Staurosporine	37-50	cyclin D1	Homo sapiens	5-14
7795236-8	1995	To address these possibilities, we constructed two stable Zn+2-inducible, cyclin D1-overexpressing Dami cell lines.	Zinc	58-62	cyclin D1	Homo sapiens	74-83
7795236-9	1995	Cyclin D1 expression alone was not sufficient to induce polyploidy, but in conjunction with PMA-induced differentiation, polyploidization was slightly enhanced.	Tetradecanoylphorbol Acetate	92-95	cyclin D1	Homo sapiens	0-9
7675778-11	1995	Nuclear cyclin D1 protein can be detected in approximately one-third of infiltrating breast carcinomas using an immunohistochemical technique on formalin-fixed, paraffin-embedded tissue.	Formaldehyde	145-153	cyclin D1	Homo sapiens	8-17
7675778-11	1995	Nuclear cyclin D1 protein can be detected in approximately one-third of infiltrating breast carcinomas using an immunohistochemical technique on formalin-fixed, paraffin-embedded tissue.	Paraffin	161-169	cyclin D1	Homo sapiens	8-17
7705920-5	1995	Amplification (AMP) of int-2 was observed in 11.2%, of bcl-1 in 9.4%, of c-myc in 5.7% and of c-erbB-2 in 8.6% of the carcinomas.	Adenosine Monophosphate	15-18	cyclin D1	Homo sapiens	55-60
7612496-3	1995	PATIENTS AND METHODS: To assess the utility of in situ hybridization (ISH) to detect cyclin D1 mRNA expression in formalin-fixed, paraffin embedded tissue, five MCL specimens from three patients and two cases of B-cell small lymphocytic lymphoma (B-SLL) were studied.	Formaldehyde	114-122	cyclin D1	Homo sapiens	85-94
7612496-3	1995	PATIENTS AND METHODS: To assess the utility of in situ hybridization (ISH) to detect cyclin D1 mRNA expression in formalin-fixed, paraffin embedded tissue, five MCL specimens from three patients and two cases of B-cell small lymphocytic lymphoma (B-SLL) were studied.	Paraffin	130-138	cyclin D1	Homo sapiens	85-94
7612496-5	1995	RESULTS: ISH was performed using anti-sense 3H-labeled RNA probes for the cyclin D1 3" untranslated region (pPL7) and partial cyclin D1 cDNA (pPL8).	Tritium	44-46	cyclin D1	Homo sapiens	74-83
7612496-9	1995	CONCLUSIONS: Overexpression of cyclin D1 mRNA can be detected in MCL by ISH using formalin fixed paraffin embedded tissue.	Formaldehyde	82-90	cyclin D1	Homo sapiens	31-40
7612496-9	1995	CONCLUSIONS: Overexpression of cyclin D1 mRNA can be detected in MCL by ISH using formalin fixed paraffin embedded tissue.	Paraffin	97-105	cyclin D1	Homo sapiens	31-40
8852336-9	1995	Alterations in genes involved in regulating the cell cycle such as cyclin D1 and the retinoblastoma (Rb) gene have also been shown to influence cellular response to MTX.	Methotrexate	165-168	cyclin D1	Homo sapiens	67-76
7546834-4	1995	Induction of cyclin D1 is an early event in mitogenic stimulation of breast cancer cells by growth factors and steroids.	Steroids	111-119	cyclin D1	Homo sapiens	13-22
8852336-10	1995	Overexpression of cyclin D1 in HT1080, a human fibrosarcoma cell line, results in decreased MTX sensitivity.	Methotrexate	92-95	cyclin D1	Homo sapiens	18-27
8582199-7	1995	These results suggest that cyclin D1 is a target for regulation of cell cycle progression by sex steroids and their antagonists.	Steroids	97-105	cyclin D1	Homo sapiens	27-36
7980579-0	1994	Suppression of cyclin D1 mRNA expression by the angiogenesis inhibitor TNP-470 (AGM-1470) in vascular endothelial cells.	O-(Chloroacetylcarbamoyl)fumagillol	80-88	cyclin D1	Homo sapiens	15-24
7531681-1	1994	Immunohistochemical expression of PRAD1/cyclin D1 protein has been investigated in 106 tissue specimens of 104 cases of lymphoma, non-neoplastic lymphoid disorders and other hematologic malignancies by employing the monoclonal antibody 5D4 with formalin-fixed paraffin-embedded sections, using the microwave oven heating method.	Formaldehyde	245-253	cyclin D1	Homo sapiens	34-39
7531681-1	1994	Immunohistochemical expression of PRAD1/cyclin D1 protein has been investigated in 106 tissue specimens of 104 cases of lymphoma, non-neoplastic lymphoid disorders and other hematologic malignancies by employing the monoclonal antibody 5D4 with formalin-fixed paraffin-embedded sections, using the microwave oven heating method.	Paraffin	260-268	cyclin D1	Homo sapiens	34-39
7849266-5	1994	Transcriptional activation of c-fos, c-myc and cyclin D1 by estrogens and progestins in breast cancer cells and inhibition of expression of these genes by antiestrogens provide a paradigm for further understanding cell cycle control by steroids.	Steroids	236-244	cyclin D1	Homo sapiens	47-56
8058338-4	1994	In agreement with this observation, forskolin treatment, but not TPA stimulation, led to increased phosphorylation of cyclin D1 in vivo.	Colforsin	36-45	cyclin D1	Homo sapiens	118-127
8058338-5	1994	Phosphoamino acid analysis and two-dimensional phosphopeptide mapping of wild-type and truncated cyclin D1 proteins showed that PKA phosphorylates three distinct serine residues in cyclin D1 at positions 90, 197 and 234.	Serine	162-168	cyclin D1	Homo sapiens	97-106
8058338-5	1994	Phosphoamino acid analysis and two-dimensional phosphopeptide mapping of wild-type and truncated cyclin D1 proteins showed that PKA phosphorylates three distinct serine residues in cyclin D1 at positions 90, 197 and 234.	Serine	162-168	cyclin D1	Homo sapiens	181-190
8058338-6	1994	Serine-90 is located within the cyclin box, raising the possibility that phosphorylation of cyclin D1 might play a role in regulating the interaction with other proteins.	Serine	0-6	cyclin D1	Homo sapiens	92-101
8036001-5	1994	Antibody-mediated and anti-sense oligonucleotide "knockout" experiments revealed that the aberrantly expressed BCL-1/cyclin D1 protein is required for G1 phase progression of all four B-cell tumours with the BCL-1 rearrangement.	Oligonucleotides	33-48	cyclin D1	Homo sapiens	111-116
8036001-5	1994	Antibody-mediated and anti-sense oligonucleotide "knockout" experiments revealed that the aberrantly expressed BCL-1/cyclin D1 protein is required for G1 phase progression of all four B-cell tumours with the BCL-1 rearrangement.	Oligonucleotides	33-48	cyclin D1	Homo sapiens	117-126
8078506-9	1994	In contrast, the expression of cyclin D1 mRNA was induced by TPA, while its expression in control cells was undetectable by Northern blot hybridization throughout the cell cycle.	Tetradecanoylphorbol Acetate	61-64	cyclin D1	Homo sapiens	31-40
7983166-4	1994	These included: (i) a dramatic decrease in the expression of cyclin A, cyclin B and cdk2, and surprisingly an up-regulation of cyclin D1 in TPA-induced macrophage-like cells; (ii) a down-regulation of cyclin E in retinoic acid-induced granulocytic cells; and (iii) a decreased abundance of cyclin D1 and D2, but high levels of cyclin A, B and E RNA in DMSO-induced granulocytic cells.	Tetradecanoylphorbol Acetate	140-143	cyclin D1	Homo sapiens	127-136
7983166-4	1994	These included: (i) a dramatic decrease in the expression of cyclin A, cyclin B and cdk2, and surprisingly an up-regulation of cyclin D1 in TPA-induced macrophage-like cells; (ii) a down-regulation of cyclin E in retinoic acid-induced granulocytic cells; and (iii) a decreased abundance of cyclin D1 and D2, but high levels of cyclin A, B and E RNA in DMSO-induced granulocytic cells.	Tetradecanoylphorbol Acetate	140-143	cyclin D1	Homo sapiens	290-299
8168995-7	1994	Antibody-mediated and anti-sense oligonucleotide knockout experiments demonstrate the requirement for the cell-cycle regulatory function of cyclin D1 in breast cancer lines with single or multiple copies of the gene and reveal the absence of such a requirement in the cell lines with Rb defects.	Oligonucleotides	33-48	cyclin D1	Homo sapiens	140-149
7518196-7	1994	Nuclear cyclin D1 protein can be detected in all cases of MCL and in rare cases of B-SLL/CLL using an immunohistochemical technique on formalin-fixed, paraffin-embedded tissue, and it does not appear to be detectable in reactive hyperplasias and other low-grade B-cell lymphomas.	Formaldehyde	135-143	cyclin D1	Homo sapiens	8-17
7518196-7	1994	Nuclear cyclin D1 protein can be detected in all cases of MCL and in rare cases of B-SLL/CLL using an immunohistochemical technique on formalin-fixed, paraffin-embedded tissue, and it does not appear to be detectable in reactive hyperplasias and other low-grade B-cell lymphomas.	Paraffin	151-159	cyclin D1	Homo sapiens	8-17
8389378-0	1993	Human cyclin D1 encodes a labile nuclear protein whose synthesis is directly induced by growth factors and suppressed by cyclic AMP.	Cyclic AMP	121-131	cyclin D1	Homo sapiens	6-15
8195927-2	1994	In an attempt to elucidate the potential role of cyclin D1 (a gene located within the 11q13 amplicon and a candidate BCL-1, PRAD-1 oncogene) in the pathogenesis of human neoplasias, we have developed and characterized a novel monoclonal antibody specifically recognizing cyclin D1 protein in various assays including immunohistochemistry on frozen and paraffin sections.	Paraffin	352-360	cyclin D1	Homo sapiens	49-58
8242751-4	1993	p21CIP1 is a potent, tight-binding inhibitor of Cdks and can inhibit the phosphorylation of Rb by cyclin A-Cdk2, cyclin E-Cdk2, cyclin D1-Cdk4, and cyclin D2-Cdk4 complexes.	Rubidium	92-94	cyclin D1	Homo sapiens	128-137
21573444-4	1993	An essential role for cyclin D1 in osteosarcoma cell proliferation is inferred by the efficacy of an antisense oligo-deoxynucleotide strategy directed against this locus.	Oligodeoxyribonucleotides	111-132	cyclin D1	Homo sapiens	22-31
8373383-0	1993	Increment of the cyclin D1 mRNA level in TPA-treated three human myeloid leukemia cell lines: HEL, CMK and HL-60 cells.	Tetradecanoylphorbol Acetate	41-44	cyclin D1	Homo sapiens	17-26
8373383-2	1993	Unexpectedly, the cyclin D1 mRNA level markedly increased in the HEL cells when the cells were growth-arrested by TPA, while the amounts of cyclin E and A mRNAs decreased to an almost undetectable level in HEL cells after incubation with TPA.	Tetradecanoylphorbol Acetate	114-117	cyclin D1	Homo sapiens	18-27
8373383-3	1993	The similar marked increment of the cyclin D1 mRNA level was observed in other leukemia cell lines, CMK and HL-60 cells, after incubation with TPA.	Tetradecanoylphorbol Acetate	143-146	cyclin D1	Homo sapiens	36-45
8247014-8	1993	After dexamethasone withdrawal, c-myc and cyclin D1 expression transiently peak at 2 and 4 h, respectively.	Dexamethasone	6-19	cyclin D1	Homo sapiens	42-51
8479754-0	1993	Two potentially oncogenic cyclins, cyclin A and cyclin D1, share common properties of subunit configuration, tyrosine phosphorylation and physical association with the Rb protein.	Tyrosine	109-117	cyclin D1	Homo sapiens	48-57
8479754-6	1993	Moreover, cyclin D1 was found to be phosphorylated on tyrosine residues in vivo and, like cyclin A, was readily phosphorylated by pp60c-src in vitro.	Tyrosine	54-62	cyclin D1	Homo sapiens	10-19
8389378-6	1993	Cyclin D1 is directly induced by growth factors, i.e. in the presence of cycloheximide, and its expression does not significantly fluctuate during the cell cycle in synchronized cells.	Cycloheximide	73-86	cyclin D1	Homo sapiens	0-9
8389378-9	1993	Interestingly, cyclin D1 expression is stimulated by the protein kinase C activator TPA, but suppressed by dibutyryl-cAMP and the adenylate cyclase inducer forskolin, pointing to multiple regulatory pathways controlling cyclin D1 expression.	Tetradecanoylphorbol Acetate	84-87	cyclin D1	Homo sapiens	15-24
8389378-9	1993	Interestingly, cyclin D1 expression is stimulated by the protein kinase C activator TPA, but suppressed by dibutyryl-cAMP and the adenylate cyclase inducer forskolin, pointing to multiple regulatory pathways controlling cyclin D1 expression.	Bucladesine	107-121	cyclin D1	Homo sapiens	15-24
8389378-9	1993	Interestingly, cyclin D1 expression is stimulated by the protein kinase C activator TPA, but suppressed by dibutyryl-cAMP and the adenylate cyclase inducer forskolin, pointing to multiple regulatory pathways controlling cyclin D1 expression.	Colforsin	156-165	cyclin D1	Homo sapiens	15-24
1409718-7	1992	Cycloheximide partially blocks the induction of CCND1 and CCND3 gene expression by serum, suggesting that both de novo protein synthesis-dependent and -independent pathways contribute to induction.	Cycloheximide	0-13	cyclin D1	Homo sapiens	48-53
1431100-2	1992	Mutation of the E site in the VH1 promoter diminishes transcription in vivo to 59% of wild-type and transcription from the BCL1 promoter in vitro is inhibited to an average of 39% of wild-type by competition with E site oligonucleotides.	Oligonucleotides	220-236	cyclin D1	Homo sapiens	123-127