PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 15731173-4 2005 MM cells expressing one or more HAS1 variants synthesize extracellular and/or intracellular hyaluronan (HA). Hyaluronic Acid 92-102 hyaluronan synthase 1 Homo sapiens 32-36 15870928-9 2005 Serum hyaluronan levels were higher in the HAS1-positive group than in the HAS1-negative group, but the expression of HAS2 and HAS3 was unrelated to serum hyaluronan levels. Hyaluronic Acid 6-16 hyaluronan synthase 1 Homo sapiens 43-47 15905585-0 2005 Effects of leflunomide on hyaluronan synthases (HAS): NF-kappa B-independent suppression of IL-1-induced HAS1 transcription by leflunomide. Leflunomide 127-138 hyaluronan synthase 1 Homo sapiens 105-109 15905585-5 2005 Additional experiments revealed that in FLS, leflunomide specifically blocked the induction of HAS1. Leflunomide 45-56 hyaluronan synthase 1 Homo sapiens 95-99 15905585-10 2005 More importantly, two tyrosine kinase inhibitors mimicked the effect of leflunomide in that both blocked IL-1beta-induced HAS1 activation without affecting HAS2 or HAS3. Leflunomide 72-83 hyaluronan synthase 1 Homo sapiens 122-126 15905585-11 2005 These data point at HAS1 activation as the possible cause for unfettered HA production in rheumatoid arthritis and might explain, at least in part, the beneficial effects of leflunomide treatment. Leflunomide 174-185 hyaluronan synthase 1 Homo sapiens 20-24 15905585-12 2005 These findings also support the concept that IL-1beta-induced HAS1 activation depends on the activation of tyrosine kinases, and indicate that leflunomide blocks HA release by suppressing tyrosine kinases rather than through inhibition of NF-kappaB translocation. Leflunomide 143-154 hyaluronan synthase 1 Homo sapiens 62-66 15794859-1 2005 The hyaluronan synthase 1 (HAS1) gene encodes a plasma membrane protein that synthesizes hyaluronan, an extracellular matrix molecule. Hyaluronic Acid 4-14 hyaluronan synthase 1 Homo sapiens 27-31 11453924-4 2001 As hyaluronan is considered to be synthesized by hyaluronan synthase (HAS), which is composed of three genetically distinct isoforms (HAS1, HAS2 and HAS3), the cells responsible for the accumulation of hyaluronan in lesional skin were immunohistochemically examined using antibodies for HAS1, HAS2 and HAS3. Hyaluronic Acid 3-13 hyaluronan synthase 1 Homo sapiens 134-138 13130151-0 2004 Glucocorticoids inhibit induced and non-induced mRNA accumulation of genes encoding hyaluronan synthases (HAS): hydrocortisone inhibits HAS1 activation by blocking the p38 mitogen-activated protein kinase signalling pathway. Hydrocortisone 112-126 hyaluronan synthase 1 Homo sapiens 136-140 11453924-4 2001 As hyaluronan is considered to be synthesized by hyaluronan synthase (HAS), which is composed of three genetically distinct isoforms (HAS1, HAS2 and HAS3), the cells responsible for the accumulation of hyaluronan in lesional skin were immunohistochemically examined using antibodies for HAS1, HAS2 and HAS3. Hyaluronic Acid 49-59 hyaluronan synthase 1 Homo sapiens 134-138 11453924-4 2001 As hyaluronan is considered to be synthesized by hyaluronan synthase (HAS), which is composed of three genetically distinct isoforms (HAS1, HAS2 and HAS3), the cells responsible for the accumulation of hyaluronan in lesional skin were immunohistochemically examined using antibodies for HAS1, HAS2 and HAS3. Hyaluronic Acid 49-59 hyaluronan synthase 1 Homo sapiens 287-291 15231668-1 2004 Hyaluronan (HA) and its biosynthetic enzymes, HA synthases (HAS1, 2, and 3) are thought to participate in cancer progression. Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 60-74 15231668-1 2004 Hyaluronan (HA) and its biosynthetic enzymes, HA synthases (HAS1, 2, and 3) are thought to participate in cancer progression. Hyaluronic Acid 12-14 hyaluronan synthase 1 Homo sapiens 60-74 14988410-1 2004 Hyaluronan (HA) is a linear glycosaminoglycan of the vertebrate extracellular matrix that is synthesized at the plasma membrane by the HA synthase (HAS) enzymes HAS1, -2 and -3. Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 161-176 14988410-1 2004 Hyaluronan (HA) is a linear glycosaminoglycan of the vertebrate extracellular matrix that is synthesized at the plasma membrane by the HA synthase (HAS) enzymes HAS1, -2 and -3. Hyaluronic Acid 12-14 hyaluronan synthase 1 Homo sapiens 161-176 13130151-8 2004 When cells were stimulated with TGF-beta, a potent activator of HAS1 mRNA transcription, treating them with hydrocortisone suppressed induced activation of HAS1 in a concentration- and time-dependent manner. Hydrocortisone 108-122 hyaluronan synthase 1 Homo sapiens 64-68 13130151-8 2004 When cells were stimulated with TGF-beta, a potent activator of HAS1 mRNA transcription, treating them with hydrocortisone suppressed induced activation of HAS1 in a concentration- and time-dependent manner. Hydrocortisone 108-122 hyaluronan synthase 1 Homo sapiens 156-160 12757764-1 2003 The glycosaminoglycan (GAG) hyaluronan (HA) is a key component of the vertebrate extracellular matrix (ECM) and is synthesised by the HA synthase (HAS) enzymes HAS1, HAS2 and HAS3 at the plasma membrane. glycosaminoglycan (gag) hyaluronan 4-38 hyaluronan synthase 1 Homo sapiens 160-164 12757764-1 2003 The glycosaminoglycan (GAG) hyaluronan (HA) is a key component of the vertebrate extracellular matrix (ECM) and is synthesised by the HA synthase (HAS) enzymes HAS1, HAS2 and HAS3 at the plasma membrane. Hyaluronic Acid 40-42 hyaluronan synthase 1 Homo sapiens 160-164 11453924-4 2001 As hyaluronan is considered to be synthesized by hyaluronan synthase (HAS), which is composed of three genetically distinct isoforms (HAS1, HAS2 and HAS3), the cells responsible for the accumulation of hyaluronan in lesional skin were immunohistochemically examined using antibodies for HAS1, HAS2 and HAS3. Hyaluronic Acid 3-13 hyaluronan synthase 1 Homo sapiens 287-291 34500840-10 2021 Pg-EE can enhance the expression of filaggrin (FLG), transglutaminase (TGM)-1, hyaluronic acid synthase (HAS)-1, and HAS-2 in human keratinocytes. pg-ee 0-5 hyaluronan synthase 1 Homo sapiens 79-111 11031254-0 2001 Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity. Glutamic Acid 37-46 hyaluronan synthase 1 Homo sapiens 66-69 10455188-7 1999 Furthermore, comparisons of hyaluronan secreted into the culture media by stable HAS transfectants showed that HAS1 and HAS3 generated hyaluronan with broad size distributions (molecular masses of 2 x 10(5) to approximately 2 x 10(6) Da), whereas HAS2 generated hyaluronan with a broad but extremely large size (average molecular mass of >2 x 10(6) Da). Hyaluronic Acid 28-38 hyaluronan synthase 1 Homo sapiens 111-115 10455188-7 1999 Furthermore, comparisons of hyaluronan secreted into the culture media by stable HAS transfectants showed that HAS1 and HAS3 generated hyaluronan with broad size distributions (molecular masses of 2 x 10(5) to approximately 2 x 10(6) Da), whereas HAS2 generated hyaluronan with a broad but extremely large size (average molecular mass of >2 x 10(6) Da). Hyaluronic Acid 135-145 hyaluronan synthase 1 Homo sapiens 111-115 10455188-7 1999 Furthermore, comparisons of hyaluronan secreted into the culture media by stable HAS transfectants showed that HAS1 and HAS3 generated hyaluronan with broad size distributions (molecular masses of 2 x 10(5) to approximately 2 x 10(6) Da), whereas HAS2 generated hyaluronan with a broad but extremely large size (average molecular mass of >2 x 10(6) Da). Hyaluronic Acid 135-145 hyaluronan synthase 1 Homo sapiens 111-115 34586189-15 2021 DEGs were identified, and interestingly, HAS1 and Fbln-7 genes may be involved in the glucose inhibitory effect on hDPC mineralization. Glucose 86-93 hyaluronan synthase 1 Homo sapiens 41-45 34621195-1 2021 Introduction: China has 1.18 million methamphetamine abusers. Methamphetamine 37-52 hyaluronan synthase 1 Homo sapiens 20-25 10594733-9 1999 We observed an increase in the migration ability of hyaluronate cDNA (HAS1 or HAS2)-transfected cells compared with control cells on glass plates covered with colloidal gold particles. hyaluronate 52-63 hyaluronan synthase 1 Homo sapiens 70-74 33777162-9 2021 Expression of skin barrier components including filaggrin and hyaluronic acid synthase-1 was increased by Cs-ME and was modulated by ERK/p38-AP-1 signaling. cs-me 106-111 hyaluronan synthase 1 Homo sapiens 62-88 34829773-8 2021 Furthermore, OM-85 increased the level of sACE2 (p < 0.05), hyaluronic acid (p < 0.002), and hyaluronan synthase 1 (p < 0.01). om-85 13-18 hyaluronan synthase 1 Homo sapiens 93-114 34326469-6 2021 Two genes in the methionine cycle, MAT2A, and AHCY are potential targets for HAS treatments. Methionine 17-27 hyaluronan synthase 1 Homo sapiens 77-80 34331686-3 2021 Among the different endothelial-derived mediators, nitric oxide is produced by nitric oxide synthase and has a critical role in regulating endothelial function. Nitric Oxide 51-63 hyaluronan synthase 1 Homo sapiens 105-108 34326469-5 2021 HAS has high stemness and high methionine cycle activity compared to classical GC. Methionine 31-41 hyaluronan synthase 1 Homo sapiens 0-3 34445570-9 2021 Moreover, kahweol increased the outcome of HAS1, HAS2, occludin, and TGM-1 from six hours in a dose-dependent manner as well as the activation of STAT1 from six hours. kahweol 10-17 hyaluronan synthase 1 Homo sapiens 43-47 34203343-7 2021 To contain this risk, the new European directive on the quality of water intended for human consumption has introduced for the first time Legionella as a microbiological parameter to be investigated in domestic water systems. Water 67-72 hyaluronan synthase 1 Homo sapiens 104-107 34203343-7 2021 To contain this risk, the new European directive on the quality of water intended for human consumption has introduced for the first time Legionella as a microbiological parameter to be investigated in domestic water systems. Water 211-216 hyaluronan synthase 1 Homo sapiens 104-107 34063955-7 2021 Upregulation of COL11A1, CTNND1, TIMP3, and TNC and downregulation of HAS1, ITGA3, ITGB1, LAMA3, MMP1, and MMP11 were detected in RPM exposed MSCs. Sirolimus 130-133 hyaluronan synthase 1 Homo sapiens 70-74 34331686-6 2021 Given the important role of such processes in the development of endothelium dysfunction, a role for curcumin in the prevention or treatment of this condition has been hypothesized. Curcumin 101-109 hyaluronan synthase 1 Homo sapiens 159-162 33672928-2 2021 Low-temperature argon plasma (LTAP) has shown the possibility of being used for the treatment of various skin diseases, such as atopic dermatitis and skin cancer. Argon 16-21 hyaluronan synthase 1 Homo sapiens 36-39 2557769-2 1989 Recordings of the outward current(s), which is responsible for the resting potential and early repolarization of the action potential in human right atrium, consistently showed that this tissue has 1) a relatively small inwardly rectifying background potassium current (IK1) which generates the resting potential in mammalian ventricular tissue and Purkinje fibers, and 2) a large time- and voltage-dependent, but Ca2(+)-independent, transient outward current. Potassium 251-260 hyaluronan synthase 1 Homo sapiens 194-199 667413-1 1978 The identification and purification of the acetylcholine receptor molecule has permitted a major advance in understanding the pathogenesis of Myasthenia gravis. Acetylcholine 43-56 hyaluronan synthase 1 Homo sapiens 75-78 35032523-1 2022 The utility of remdesivir treatment in COVID-19 patients is currently limited by the necessity to administer this antiviral intravenously, which has generally limited its use to hospitalized patients. remdesivir 15-25 hyaluronan synthase 1 Homo sapiens 145-148 35106474-7 2022 Hyaluronan synthase 1, a critical enzyme in the synthetic pathway for hyaluronic acid, was knocked down in SN12L1 cells and in vitro experiments revealed inhibition of interstitial flow induced migration. Hyaluronic Acid 70-85 hyaluronan synthase 1 Homo sapiens 0-21 2646889-1 1989 Angina pectoris that is mainly caused by coronary artery spasm (coronary spastic angina) has 1 or more of the following characteristics: (1) the attack occurs at rest, (2) the attack is associated with ST-segment elevation on the electrocardiogram (not necessarily so in case of old myocardial infarction), (3) the attack has a variable exercise threshold, and (4) the attack is suppressed by calcium antagonists but not by beta-adrenergic blocking agents. Calcium 393-400 hyaluronan synthase 1 Homo sapiens 89-94 2971084-1 1988 The family at increased risk for future coronary heart disease is the family with a member who has 1) had one or more myocardial infarctions before age 55 years; 2) has levels of LDL cholesterol greater than 75th percentile for age; 3) has excessively low levels of HDL2 cholesterol; 4) has hypertension or has had a stroke, or both; 5) has excessive weight at any age and excessive weight gain during adulthood, or 6) smokes in the household. Cholesterol 183-194 hyaluronan synthase 1 Homo sapiens 95-100 2971084-1 1988 The family at increased risk for future coronary heart disease is the family with a member who has 1) had one or more myocardial infarctions before age 55 years; 2) has levels of LDL cholesterol greater than 75th percentile for age; 3) has excessively low levels of HDL2 cholesterol; 4) has hypertension or has had a stroke, or both; 5) has excessive weight at any age and excessive weight gain during adulthood, or 6) smokes in the household. Cholesterol 271-282 hyaluronan synthase 1 Homo sapiens 95-100 31276783-2 2020 Hyaluronan is synthesized by the hyaluronan synthase family of enzymes, HAS1, HAS2 and HAS3; the HAS1 and HAS3 genes give rise to different transcripts through alternative splicing, and the HAS2 gene to a non-coding RNA antisense transcript in addition to the protein-coding transcript. Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 72-76 33346526-10 2020 Formulations of rhTE crosslinked with dHA demonstrated increased expression of hyaluronic acid synthase 1 and ex vivo results revealed increased moisture content and glycosaminoglycan (GAG) deposition versus dermal filler control. rhte 16-20 hyaluronan synthase 1 Homo sapiens 79-105 33346526-10 2020 Formulations of rhTE crosslinked with dHA demonstrated increased expression of hyaluronic acid synthase 1 and ex vivo results revealed increased moisture content and glycosaminoglycan (GAG) deposition versus dermal filler control. Dihydroalprenolol 38-41 hyaluronan synthase 1 Homo sapiens 79-105 33026423-4 2020 In particular, the human brain has 1) larger total SA in the right compared with the left cerebral hemisphere, 2) a global torque-like asymmetry pattern of widespread thicker cortex in the left compared with the right frontal and the right compared with the left temporo-parieto-occipital lobe, and 3) local asymmetries, most notably in medial occipital cortex and superior temporal gyrus, where rightward asymmetry is observed for both SA and CT. sa 51-53 hyaluronan synthase 1 Homo sapiens 31-36 33026423-4 2020 In particular, the human brain has 1) larger total SA in the right compared with the left cerebral hemisphere, 2) a global torque-like asymmetry pattern of widespread thicker cortex in the left compared with the right frontal and the right compared with the left temporo-parieto-occipital lobe, and 3) local asymmetries, most notably in medial occipital cortex and superior temporal gyrus, where rightward asymmetry is observed for both SA and CT. sa 437-439 hyaluronan synthase 1 Homo sapiens 31-36 32551924-4 2021 OBJECTIVE: We sought to determine the effect of PGD2 on the mRNA expression of three isoforms of membrane-bound hyaluronic acid synthase (HAS1, HAS2 and HAS3) in fibroblasts, the major source of hyaluronan production, derived from CRS patients. Hyaluronic Acid 112-127 hyaluronan synthase 1 Homo sapiens 138-142 33360073-9 2021 RNA sequencing analysis indicated that PL"s protective effects might be associated with modulating hyaluronan synthase 1 (HAS-1) expression. pl 39-41 hyaluronan synthase 1 Homo sapiens 99-120 33360073-9 2021 RNA sequencing analysis indicated that PL"s protective effects might be associated with modulating hyaluronan synthase 1 (HAS-1) expression. pl 39-41 hyaluronan synthase 1 Homo sapiens 122-127 31276783-2 2020 Hyaluronan is synthesized by the hyaluronan synthase family of enzymes, HAS1, HAS2 and HAS3; the HAS1 and HAS3 genes give rise to different transcripts through alternative splicing, and the HAS2 gene to a non-coding RNA antisense transcript in addition to the protein-coding transcript. Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 97-101 31810747-1 2020 AKT1 encodes a serine/threonine kinase that has as one of its best-known substrates glycogen synthase kinase-3 (GSK3), a primary target for lithium. Serine 15-21 hyaluronan synthase 1 Homo sapiens 44-47 33543028-5 2020 The present study demonstrates that salicylate, a break down product of aspirin in vivo, alters the organization of hyaluronan matrices by affecting the expression levels of hyaluronan synthesizing (HAS1, 2, 3) and degrading (HYAL-1, -2) enzymes, and that of hyaluronan receptor CD44. Salicylates 36-46 hyaluronan synthase 1 Homo sapiens 199-203 31810747-1 2020 AKT1 encodes a serine/threonine kinase that has as one of its best-known substrates glycogen synthase kinase-3 (GSK3), a primary target for lithium. Lithium 140-147 hyaluronan synthase 1 Homo sapiens 44-47 31042587-10 2019 NT157 has a stronger effect on ALL cells, and thus the direct inhibition of IRS1 may be a potential therapeutic target in ALL. NT157 0-5 hyaluronan synthase 1 Homo sapiens 6-9 31075987-5 2019 alpha-Ionone treatment also increased hyaluronic acid contents, and this effect was accompanied by an upregulation of mRNA expression of genes (HAS1 and HAS2) involved in hyaluronic acid synthesis. alpha-ionone 0-12 hyaluronan synthase 1 Homo sapiens 144-148 31075987-5 2019 alpha-Ionone treatment also increased hyaluronic acid contents, and this effect was accompanied by an upregulation of mRNA expression of genes (HAS1 and HAS2) involved in hyaluronic acid synthesis. Hyaluronic Acid 171-186 hyaluronan synthase 1 Homo sapiens 144-148 31186660-5 2019 Mc-ME also showed antidehydration properties by inducing the expression of natural moisturizing factors such as filaggrin (FLG), transglutaminase-1 (TGM-1), and hyaluronic acid synthase (HAS)-1, -2, and -3 in HaCaT cells. mc-me 0-5 hyaluronan synthase 1 Homo sapiens 161-205 29709595-3 2019 Increased expression of the genes of hyaluronan synthases (HAS1-3) are infrequent in human tumors, while posttranslational modifications that activate the HAS enzymes, and glucose shunted to the UDP-sugar substrates HASs, can have crucial contributions to tumor hyaluronan synthesis. Uridine Diphosphate Sugars 195-204 hyaluronan synthase 1 Homo sapiens 59-65 29709595-3 2019 Increased expression of the genes of hyaluronan synthases (HAS1-3) are infrequent in human tumors, while posttranslational modifications that activate the HAS enzymes, and glucose shunted to the UDP-sugar substrates HASs, can have crucial contributions to tumor hyaluronan synthesis. Hyaluronic Acid 37-47 hyaluronan synthase 1 Homo sapiens 59-65 30507579-2 2019 Brain ECM is abundant in hyaluronan (HA), a non-sulfated glycosaminoglycan synthesized by HA synthases (HAS) 1-3 in a high molecular weight (MW) form that is degraded into lower MW fragments. Hyaluronic Acid 25-35 hyaluronan synthase 1 Homo sapiens 90-112 30507579-2 2019 Brain ECM is abundant in hyaluronan (HA), a non-sulfated glycosaminoglycan synthesized by HA synthases (HAS) 1-3 in a high molecular weight (MW) form that is degraded into lower MW fragments. Glycosaminoglycans 57-74 hyaluronan synthase 1 Homo sapiens 90-112 29626161-7 2018 AMP and adenosine, the degradation products of ATP, markedly inhibited HAS2 expression and, despite concomitant up-regulation of HAS1 and HAS3, inhibited hyaluronan synthesis. Adenosine Monophosphate 0-3 hyaluronan synthase 1 Homo sapiens 129-133 29316635-4 2018 RT-PCR showed that EGCG increased the expression of natural moisturizing factor-related genes filaggrin (FLG), transglutaminase-1, HAS-1, and HAS-2. epigallocatechin gallate 19-23 hyaluronan synthase 1 Homo sapiens 131-136 29156912-13 2017 Significant SNVs associated with dexamethasone response were from genes involved in extracellular matrix (HAS1, ADAMTS16) and cytoskeleton regulation (GAS2L2). Dexamethasone 33-46 hyaluronan synthase 1 Homo sapiens 106-110 29063508-4 2018 In this study, we measured the mRNA expression of hyaluronic acid-related proteins: hyaluronan synthase (HAS) 1-3, hyaluronidase-1, -2, and hyaluronic acid-binding protein (versican). Hyaluronic Acid 50-65 hyaluronan synthase 1 Homo sapiens 84-113 28604766-1 2017 The levels of hyaluronan, a ubiquitous glycosaminoglycan prominent in the extracellular matrix, is balanced through the actions of hyaluronan-synthesizing enzymes (HAS1, 2 and 3) and degrading hyaluronidases (Hyal 1, 2, 3 and PH20). Hyaluronic Acid 14-24 hyaluronan synthase 1 Homo sapiens 164-177 29137675-1 2017 BACKGROUND: Human hyaluronic acid (HA) molecules are synthesized by three membrane spanning Hyaluronic Acid Synthases (HAS1, HAS2 and HAS3). Hyaluronic Acid 18-33 hyaluronan synthase 1 Homo sapiens 119-123 29137675-1 2017 BACKGROUND: Human hyaluronic acid (HA) molecules are synthesized by three membrane spanning Hyaluronic Acid Synthases (HAS1, HAS2 and HAS3). Hyaluronic Acid 35-37 hyaluronan synthase 1 Homo sapiens 119-123 26883802-2 2016 Hyaluronan synthesis requires the transport of hyaluronan synthases (HAS1-3) from Golgi to plasma membrane (PM), where the enzymes are activated. Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 69-75 26407048-2 2016 The prescription plan has 1-year validity and clinical condition of the patient treated with NOACs should be reassessed at 1-year prescription renewal. N(4)-oleylcytosine arabinoside 93-98 hyaluronan synthase 1 Homo sapiens 22-27 33401818-1 2016 Electrolyzed water (EW) has gained immense popularity over the last few decades as a novel broad-spectrum sanitizer. Water 13-18 hyaluronan synthase 1 Homo sapiens 24-27 33401818-7 2016 AEW, in particular, has shown limited efficacy on utensils, food products, and surfaces owing to various factors, the most important of which include the type of surface, presence of organic matter, and type of tape water used. Water 216-221 hyaluronan synthase 1 Homo sapiens 20-23 26627828-1 2016 Hyaluronan (HA) is synthesized by three HA synthases (HAS1, HAS2, and HAS3) and secreted in the extracellular matrix. Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 54-58 26627828-1 2016 Hyaluronan (HA) is synthesized by three HA synthases (HAS1, HAS2, and HAS3) and secreted in the extracellular matrix. Hyaluronic Acid 12-14 hyaluronan synthase 1 Homo sapiens 54-58 27120017-5 2016 Expression of the HAS1 isoform of hyaluronan synthase was significantly higher in hyaluronan hydrogels compared to blank-slate poly(ethylene glycol) diacrylate (PEGDA) hydrogels. poly(ethylene glycol)diacrylate 127-159 hyaluronan synthase 1 Homo sapiens 18-22 27120017-5 2016 Expression of the HAS1 isoform of hyaluronan synthase was significantly higher in hyaluronan hydrogels compared to blank-slate poly(ethylene glycol) diacrylate (PEGDA) hydrogels. poly(ethylene glycol)diacrylate 161-166 hyaluronan synthase 1 Homo sapiens 18-22 24590928-4 2015 The relative secretion levels of hyaluronan by the different human fibroblasts tested were attributable to the relative expression of hyaluronan synthases 1, 2, 3 but not hyaluronidases 1, 2 enzymes at the gene and protein levels among those fibroblasts. Hyaluronic Acid 33-43 hyaluronan synthase 1 Homo sapiens 134-162 25795779-1 2015 In vertebrates, hyaluronan is produced in the plasma membrane from cytosolic UDP-sugar substrates by hyaluronan synthase 1-3 (HAS1-3) isoenzymes that transfer N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcUA) in alternative positions in the growing polysaccharide chain during its simultaneous extrusion into the extracellular space. Hyaluronic Acid 16-26 hyaluronan synthase 1 Homo sapiens 101-124 25843802-1 2015 Hyaluronan (HA) is a key component of the vertebrate extracellular matrix that is synthesized at the plasma membrane by the hyaluronan synthases including HAS1, HAS2 and HAS3. Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 155-159 25843802-1 2015 Hyaluronan (HA) is a key component of the vertebrate extracellular matrix that is synthesized at the plasma membrane by the hyaluronan synthases including HAS1, HAS2 and HAS3. Hyaluronic Acid 12-14 hyaluronan synthase 1 Homo sapiens 155-159 26403402-12 2015 Glucosamine sulphate acts not only as building block in the biosynthesis of glycosaminoglycan chains, but also as a booster of hyaluronan synthase 1. Glucosamine 0-20 hyaluronan synthase 1 Homo sapiens 127-148 25795779-1 2015 In vertebrates, hyaluronan is produced in the plasma membrane from cytosolic UDP-sugar substrates by hyaluronan synthase 1-3 (HAS1-3) isoenzymes that transfer N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcUA) in alternative positions in the growing polysaccharide chain during its simultaneous extrusion into the extracellular space. Hyaluronic Acid 16-26 hyaluronan synthase 1 Homo sapiens 126-132 25795779-1 2015 In vertebrates, hyaluronan is produced in the plasma membrane from cytosolic UDP-sugar substrates by hyaluronan synthase 1-3 (HAS1-3) isoenzymes that transfer N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcUA) in alternative positions in the growing polysaccharide chain during its simultaneous extrusion into the extracellular space. Uridine Diphosphate Sugars 77-86 hyaluronan synthase 1 Homo sapiens 126-132 25795779-1 2015 In vertebrates, hyaluronan is produced in the plasma membrane from cytosolic UDP-sugar substrates by hyaluronan synthase 1-3 (HAS1-3) isoenzymes that transfer N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcUA) in alternative positions in the growing polysaccharide chain during its simultaneous extrusion into the extracellular space. Acetylglucosamine 159-178 hyaluronan synthase 1 Homo sapiens 101-124 25795779-1 2015 In vertebrates, hyaluronan is produced in the plasma membrane from cytosolic UDP-sugar substrates by hyaluronan synthase 1-3 (HAS1-3) isoenzymes that transfer N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcUA) in alternative positions in the growing polysaccharide chain during its simultaneous extrusion into the extracellular space. Acetylglucosamine 159-178 hyaluronan synthase 1 Homo sapiens 126-132 25795779-1 2015 In vertebrates, hyaluronan is produced in the plasma membrane from cytosolic UDP-sugar substrates by hyaluronan synthase 1-3 (HAS1-3) isoenzymes that transfer N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcUA) in alternative positions in the growing polysaccharide chain during its simultaneous extrusion into the extracellular space. Acetylglucosamine 180-186 hyaluronan synthase 1 Homo sapiens 101-124 25795779-1 2015 In vertebrates, hyaluronan is produced in the plasma membrane from cytosolic UDP-sugar substrates by hyaluronan synthase 1-3 (HAS1-3) isoenzymes that transfer N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcUA) in alternative positions in the growing polysaccharide chain during its simultaneous extrusion into the extracellular space. Acetylglucosamine 180-186 hyaluronan synthase 1 Homo sapiens 126-132 25795779-1 2015 In vertebrates, hyaluronan is produced in the plasma membrane from cytosolic UDP-sugar substrates by hyaluronan synthase 1-3 (HAS1-3) isoenzymes that transfer N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcUA) in alternative positions in the growing polysaccharide chain during its simultaneous extrusion into the extracellular space. Glucuronic Acid 192-207 hyaluronan synthase 1 Homo sapiens 101-124 25795779-1 2015 In vertebrates, hyaluronan is produced in the plasma membrane from cytosolic UDP-sugar substrates by hyaluronan synthase 1-3 (HAS1-3) isoenzymes that transfer N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcUA) in alternative positions in the growing polysaccharide chain during its simultaneous extrusion into the extracellular space. Glucuronic Acid 192-207 hyaluronan synthase 1 Homo sapiens 126-132 25795779-1 2015 In vertebrates, hyaluronan is produced in the plasma membrane from cytosolic UDP-sugar substrates by hyaluronan synthase 1-3 (HAS1-3) isoenzymes that transfer N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcUA) in alternative positions in the growing polysaccharide chain during its simultaneous extrusion into the extracellular space. Glucuronic Acid 209-214 hyaluronan synthase 1 Homo sapiens 101-124 25795779-1 2015 In vertebrates, hyaluronan is produced in the plasma membrane from cytosolic UDP-sugar substrates by hyaluronan synthase 1-3 (HAS1-3) isoenzymes that transfer N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcUA) in alternative positions in the growing polysaccharide chain during its simultaneous extrusion into the extracellular space. Glucuronic Acid 209-214 hyaluronan synthase 1 Homo sapiens 126-132 25795779-1 2015 In vertebrates, hyaluronan is produced in the plasma membrane from cytosolic UDP-sugar substrates by hyaluronan synthase 1-3 (HAS1-3) isoenzymes that transfer N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcUA) in alternative positions in the growing polysaccharide chain during its simultaneous extrusion into the extracellular space. Polysaccharides 256-270 hyaluronan synthase 1 Homo sapiens 101-124 25795779-1 2015 In vertebrates, hyaluronan is produced in the plasma membrane from cytosolic UDP-sugar substrates by hyaluronan synthase 1-3 (HAS1-3) isoenzymes that transfer N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcUA) in alternative positions in the growing polysaccharide chain during its simultaneous extrusion into the extracellular space. Polysaccharides 256-270 hyaluronan synthase 1 Homo sapiens 126-132 25795779-12 2015 Interestingly, HAS1 transfection reduced the synthesis of hyaluronan obtained by HAS2 and HAS3, suggesting functional cooperation between the isoenzymes. Hyaluronic Acid 58-68 hyaluronan synthase 1 Homo sapiens 15-19 21887686-2 2012 The hyaluronic acid (HA) family includes HA synthases (HAS1, HAS2, HAS3), hyaluronidases (HYAL-1, HYAL-2, HYAL-3, HYAL-4, PH20, HYAL-P1), and HA receptors (CD44s, CD44v, RHAMM). Hyaluronic Acid 4-19 hyaluronan synthase 1 Homo sapiens 55-59 24658508-0 2014 Hyaluronan metabolism in human keratinocytes and atopic dermatitis skin is driven by a balance of hyaluronan synthases 1 and 3. Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 98-126 24658508-1 2014 Hyaluronan (HA) is a glycosaminoglycan synthesized directly into the extracellular matrix by three hyaluronan synthases (HAS1, HAS2, and HAS3). Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 121-125 24658508-1 2014 Hyaluronan (HA) is a glycosaminoglycan synthesized directly into the extracellular matrix by three hyaluronan synthases (HAS1, HAS2, and HAS3). Hyaluronic Acid 12-14 hyaluronan synthase 1 Homo sapiens 121-125 24668563-2 2014 Hyaluronan (HA) is a high molecular weight polyanionic carbohydrate produced by synthases (HAS1 through HAS3) and fragmented by oxidative/nitrosative stress and hyaluronidases (HYAL1 through HYAL4, SPAM1) common in PCa microenvironments. Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 91-95 24509846-1 2014 Hyaluronan synthases (HAS1-3) are unique in that they are active only when located in the plasma membrane, where they extrude the growing hyaluronan (HA) directly into cell surface and extracellular space. Hyaluronic Acid 138-148 hyaluronan synthase 1 Homo sapiens 22-28 24099991-2 2014 In mammals, three hyaluronan synthase isoenzymes (HAS1-3) inserted in the plasma membrane produce hyaluronan directly on cell surface. Hyaluronic Acid 18-28 hyaluronan synthase 1 Homo sapiens 50-54 24099991-5 2014 When cultured in 5 mM glucose, HAS1-transfected MCF-7 cells show very little cell surface hyaluronan, detected with a fluorescent hyaluronan binding probe. Glucose 22-29 hyaluronan synthase 1 Homo sapiens 31-35 24099991-5 2014 When cultured in 5 mM glucose, HAS1-transfected MCF-7 cells show very little cell surface hyaluronan, detected with a fluorescent hyaluronan binding probe. Hyaluronic Acid 90-100 hyaluronan synthase 1 Homo sapiens 31-35 24099991-5 2014 When cultured in 5 mM glucose, HAS1-transfected MCF-7 cells show very little cell surface hyaluronan, detected with a fluorescent hyaluronan binding probe. Hyaluronic Acid 130-140 hyaluronan synthase 1 Homo sapiens 31-35 23303191-7 2013 The results indicate that HAS1 is almost inactive in cells with low UDP-sugar supply, HAS2 activity increases with UDP-sugars, and HAS3 produces hyaluronan at high speed even with minimum substrate content. Uridine Diphosphate Sugars 115-125 hyaluronan synthase 1 Homo sapiens 26-30 23303191-7 2013 The results indicate that HAS1 is almost inactive in cells with low UDP-sugar supply, HAS2 activity increases with UDP-sugars, and HAS3 produces hyaluronan at high speed even with minimum substrate content. Hyaluronic Acid 145-155 hyaluronan synthase 1 Homo sapiens 26-30 23303191-9 2013 Comparison of different human cell types revealed ~50-fold differences in the content of UDP-N-acetylhexosamines and UDP-glucuronic acid, correlating with the expression level of Has1, suggesting cellular coordination between Has1 expression and the content of UDP-sugars. udp-n-acetylhexosamines 89-112 hyaluronan synthase 1 Homo sapiens 179-183 23303191-9 2013 Comparison of different human cell types revealed ~50-fold differences in the content of UDP-N-acetylhexosamines and UDP-glucuronic acid, correlating with the expression level of Has1, suggesting cellular coordination between Has1 expression and the content of UDP-sugars. udp-n-acetylhexosamines 89-112 hyaluronan synthase 1 Homo sapiens 226-230 23303191-9 2013 Comparison of different human cell types revealed ~50-fold differences in the content of UDP-N-acetylhexosamines and UDP-glucuronic acid, correlating with the expression level of Has1, suggesting cellular coordination between Has1 expression and the content of UDP-sugars. Uridine Diphosphate Glucuronic Acid 117-136 hyaluronan synthase 1 Homo sapiens 226-230 23303191-9 2013 Comparison of different human cell types revealed ~50-fold differences in the content of UDP-N-acetylhexosamines and UDP-glucuronic acid, correlating with the expression level of Has1, suggesting cellular coordination between Has1 expression and the content of UDP-sugars. Uridine Diphosphate Sugars 261-271 hyaluronan synthase 1 Homo sapiens 179-183 25699059-1 2015 Hyaluronan synthase 1 (HAS1) is one of three isoenzymes responsible for cellular hyaluronan synthesis. Hyaluronic Acid 81-91 hyaluronan synthase 1 Homo sapiens 0-21 25699059-1 2015 Hyaluronan synthase 1 (HAS1) is one of three isoenzymes responsible for cellular hyaluronan synthesis. Hyaluronic Acid 81-91 hyaluronan synthase 1 Homo sapiens 23-27 25699059-2 2015 Interest in HAS1 has been limited because its role in hyaluronan production seems to be insignificant compared to the two other isoenzymes, HAS2 and HAS3, which have higher enzymatic activity. Hyaluronic Acid 54-64 hyaluronan synthase 1 Homo sapiens 12-16 26448759-1 2015 Hyaluronan is a linear sugar polymer synthesized by three isoforms of hyaluronan synthases (HAS1, 2, and 3) that forms a hydrated scaffold around cells and is an essential component of the extracellular matrix. Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 92-106 26448759-1 2015 Hyaluronan is a linear sugar polymer synthesized by three isoforms of hyaluronan synthases (HAS1, 2, and 3) that forms a hydrated scaffold around cells and is an essential component of the extracellular matrix. sugar polymer 23-36 hyaluronan synthase 1 Homo sapiens 92-106 24134926-5 2014 In contrast with other glycosaminoglycans, which are synthesized in the Golgi apparatus, HA is produced at the plasma membrane by HA synthases (HAS1-3), which use cytoplasmic UDP-glucuronic acid and UDP-N-acetylglucosamine as substrates. Uridine Diphosphate Glucuronic Acid 175-194 hyaluronan synthase 1 Homo sapiens 144-148 24134926-5 2014 In contrast with other glycosaminoglycans, which are synthesized in the Golgi apparatus, HA is produced at the plasma membrane by HA synthases (HAS1-3), which use cytoplasmic UDP-glucuronic acid and UDP-N-acetylglucosamine as substrates. Uridine Diphosphate N-Acetylglucosamine 199-222 hyaluronan synthase 1 Homo sapiens 144-148 24406795-0 2014 Extensive CD44-dependent hyaluronan coats on human bone marrow-derived mesenchymal stem cells produced by hyaluronan synthases HAS1, HAS2 and HAS3. Hyaluronic Acid 25-35 hyaluronan synthase 1 Homo sapiens 127-131 23440385-5 2013 The adenosine receptor agonist NECA (10 muM) caused a strong induction of HA synthase (HAS)1 at 6 h and a weaker induction again after 24 h. Use of selective adenosine receptor antagonists revealed that adenosine A2(B) receptors (A2(B)R) mediate the early HAS1 induction, whereas late HAS1 induction was mediated via A2(A)R and A3R. Adenosine-5'-(N-ethylcarboxamide) 31-35 hyaluronan synthase 1 Homo sapiens 256-260 23440385-5 2013 The adenosine receptor agonist NECA (10 muM) caused a strong induction of HA synthase (HAS)1 at 6 h and a weaker induction again after 24 h. Use of selective adenosine receptor antagonists revealed that adenosine A2(B) receptors (A2(B)R) mediate the early HAS1 induction, whereas late HAS1 induction was mediated via A2(A)R and A3R. Adenosine-5'-(N-ethylcarboxamide) 31-35 hyaluronan synthase 1 Homo sapiens 285-289 23440385-10 2013 In conclusion, the current data suggest that adenosine via adenosine A2(B)R and A2(A)R/A3R induces HAS1. Adenosine 45-54 hyaluronan synthase 1 Homo sapiens 99-103 23303191-0 2013 Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc concentration than HAS2 and HAS3. Uridine Diphosphate N-Acetylglucosamine 54-64 hyaluronan synthase 1 Homo sapiens 0-21 23303191-0 2013 Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc concentration than HAS2 and HAS3. Uridine Diphosphate N-Acetylglucosamine 54-64 hyaluronan synthase 1 Homo sapiens 23-27 23303191-1 2013 Mammals have three homologous genes encoding proteins with hyaluronan synthase activity (Has1-3), all producing an identical polymer from UDP-N-acetylglucosamine and UDP-glucuronic acid. Polymers 125-132 hyaluronan synthase 1 Homo sapiens 89-93 23303191-1 2013 Mammals have three homologous genes encoding proteins with hyaluronan synthase activity (Has1-3), all producing an identical polymer from UDP-N-acetylglucosamine and UDP-glucuronic acid. Uridine Diphosphate N-Acetylglucosamine 138-161 hyaluronan synthase 1 Homo sapiens 89-93 23303191-1 2013 Mammals have three homologous genes encoding proteins with hyaluronan synthase activity (Has1-3), all producing an identical polymer from UDP-N-acetylglucosamine and UDP-glucuronic acid. Uridine Diphosphate Glucuronic Acid 166-185 hyaluronan synthase 1 Homo sapiens 89-93 23303191-4 2013 This failure of HAS1 to synthesize hyaluronan was compensated by increasing the cellular content of UDP-N-acetyl glucosamine by ~10-fold with 1 mm glucosamine in the growth medium. Hyaluronic Acid 35-45 hyaluronan synthase 1 Homo sapiens 16-20 23303191-7 2013 The results indicate that HAS1 is almost inactive in cells with low UDP-sugar supply, HAS2 activity increases with UDP-sugars, and HAS3 produces hyaluronan at high speed even with minimum substrate content. Uridine Diphosphate Sugars 68-77 hyaluronan synthase 1 Homo sapiens 26-30 22887999-2 2012 In contrast with other glycosaminoglycans, which are synthesized in the Golgi, HA is synthesized at the plasma membrane by one or more of the three HA synthases (HAS1-3), which use cytoplasmic UDP-glucuronic acid and UDP-N-acetylglucosamine as substrates. Uridine Diphosphate Glucuronic Acid 193-212 hyaluronan synthase 1 Homo sapiens 162-166 22887999-2 2012 In contrast with other glycosaminoglycans, which are synthesized in the Golgi, HA is synthesized at the plasma membrane by one or more of the three HA synthases (HAS1-3), which use cytoplasmic UDP-glucuronic acid and UDP-N-acetylglucosamine as substrates. Uridine Diphosphate N-Acetylglucosamine 217-240 hyaluronan synthase 1 Homo sapiens 162-166 22184056-3 2012 By knocking down Has1 and Has2 gene functions, we revealed that hyaluronan synthesized by Has1 and Has2 is necessary for the proper development of the visceral skeleton. Hyaluronic Acid 64-74 hyaluronan synthase 1 Homo sapiens 17-21 22184056-3 2012 By knocking down Has1 and Has2 gene functions, we revealed that hyaluronan synthesized by Has1 and Has2 is necessary for the proper development of the visceral skeleton. Hyaluronic Acid 64-74 hyaluronan synthase 1 Homo sapiens 90-94 21901291-0 2011 Estradiol inhibits hyaluronic acid synthase 1 expression in human vascular smooth muscle cells. Estradiol 0-9 hyaluronan synthase 1 Homo sapiens 19-45 22270036-9 2012 The skin-physiological improvement was accompanied by a significant increase in the mRNA expression of hyaluronic acid synthase-1 (HAS-1), an enzyme critically involved in the synthesis of hyaluronic acid, and a noticeable increase in gene expression involved in collagen de novo synthesis. Hyaluronic Acid 103-118 hyaluronan synthase 1 Homo sapiens 131-136 21901291-6 2011 The downregulation of HAS1 was abrogated by the estrogen receptor (ER) alpha and beta antagonist ICI182780 and could be mimicked by the ERalpha-agonist propyl-pyrazole triol (PPT). Fulvestrant 97-106 hyaluronan synthase 1 Homo sapiens 22-26 21901291-6 2011 The downregulation of HAS1 was abrogated by the estrogen receptor (ER) alpha and beta antagonist ICI182780 and could be mimicked by the ERalpha-agonist propyl-pyrazole triol (PPT). 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol 152-173 hyaluronan synthase 1 Homo sapiens 22-26 21901291-6 2011 The downregulation of HAS1 was abrogated by the estrogen receptor (ER) alpha and beta antagonist ICI182780 and could be mimicked by the ERalpha-agonist propyl-pyrazole triol (PPT). 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol 175-178 hyaluronan synthase 1 Homo sapiens 22-26 21743962-1 2011 Hyaluronan (HA) is synthesized by HA synthase (HAS) 1, HAS2 and HAS3, and degraded by hyaluronidase (HYAL) 1 and HYAL2 in a CD44-dependent manner. Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 34-53 21743962-1 2011 Hyaluronan (HA) is synthesized by HA synthase (HAS) 1, HAS2 and HAS3, and degraded by hyaluronidase (HYAL) 1 and HYAL2 in a CD44-dependent manner. Hyaluronic Acid 12-14 hyaluronan synthase 1 Homo sapiens 34-53 20960509-0 2011 Association of hyaluronic acid family members (HAS1, HAS2, and HYAL-1) with bladder cancer diagnosis and prognosis. Hyaluronic Acid 15-30 hyaluronan synthase 1 Homo sapiens 47-51 21576248-9 2011 Targeting Sp1 and UGDH with specific siRNAs also lowered hyaluronan synthase-1 (HAS-1) and HAS-2 levels and reduced hyaluronan accumulation in orbital fibroblasts. Hyaluronic Acid 57-67 hyaluronan synthase 1 Homo sapiens 80-85 20875124-0 2010 Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma. Hyaluronic Acid 82-92 hyaluronan synthase 1 Homo sapiens 22-28 20384487-1 2010 BACKGROUND: Orbital fibroblasts are involved in the pathogenesis of Graves" ophthalmopathy (GO) by producing hyaluronan (HA), synthesized by three types of hyaluronan synthases (HAS1, HAS2, and HAS3). Hyaluronic Acid 109-119 hyaluronan synthase 1 Homo sapiens 178-182 20501660-1 2010 Hyaluronan synthases (HAS1-3) are integral plasma membrane proteins that synthesize hyaluronan, a cell surface and extracellular matrix polysaccharide necessary for many biological processes. Hyaluronic Acid 84-94 hyaluronan synthase 1 Homo sapiens 22-28 20501660-1 2010 Hyaluronan synthases (HAS1-3) are integral plasma membrane proteins that synthesize hyaluronan, a cell surface and extracellular matrix polysaccharide necessary for many biological processes. Polysaccharides 136-150 hyaluronan synthase 1 Homo sapiens 22-28 20346064-2 2010 The abnormal gene implicated in WD, ATP7B, has been mapped to chromosome 13, and leads to decreased passage of copper from hepatocytes to bile. Copper 111-117 hyaluronan synthase 1 Homo sapiens 43-46 20346064-4 2010 The hepatic injury induced by the abnormal accumulation of copper in WD has variable presentation such as acute hepatitis, rapid hepatic deterioration resembling fulminant hepatic failure, or as progressive chronic liver disease in the form of chronic active hepatitis or cirrhosis. Copper 59-65 hyaluronan synthase 1 Homo sapiens 72-75 20384487-1 2010 BACKGROUND: Orbital fibroblasts are involved in the pathogenesis of Graves" ophthalmopathy (GO) by producing hyaluronan (HA), synthesized by three types of hyaluronan synthases (HAS1, HAS2, and HAS3). Hyaluronic Acid 121-123 hyaluronan synthase 1 Homo sapiens 178-182 20384487-4 2010 We hypothesize that TSHR activation, via cAMP signaling, results in induction of HAS1-3 mRNA expression and HA production by nondifferentiated GO orbital fibroblasts. Cyclic AMP 41-45 hyaluronan synthase 1 Homo sapiens 81-87 20384487-6 2010 RESULTS: FSK significantly stimulated cAMP production, HAS1 and HAS3 mRNA expression, and HA secretion in orbital fibroblasts. Colforsin 9-12 hyaluronan synthase 1 Homo sapiens 55-59 19520774-10 2009 The results of this study suggest the laromustine has 1) negligible victim potential with respect to metabolism by cytochrome P450 enzymes, 2) negligible enzyme-inducing potential, and 3) the potential in some cases to cause inhibition of CYP2B6, CYP3A4, and possibly CYP2C19 during and shortly after the duration of intravenous administration of this anticancer drug, but the clinical effects of such interactions are likely to be insignificant. laromustine 38-49 hyaluronan synthase 1 Homo sapiens 50-55 19705110-4 2009 The data obtained suggested that the low water-soluble, non-polar pesticide rotenone resulted preferentially adsorbed onto HAs by hydrophobic interaction, that was the prevailing mechanism in the order HA S1 > HA S2 >>> HA SR, whereas hydrogen bonds resulted predominant in the opposite order. Water 41-46 hyaluronan synthase 1 Homo sapiens 202-207 19705110-4 2009 The data obtained suggested that the low water-soluble, non-polar pesticide rotenone resulted preferentially adsorbed onto HAs by hydrophobic interaction, that was the prevailing mechanism in the order HA S1 > HA S2 >>> HA SR, whereas hydrogen bonds resulted predominant in the opposite order. Rotenone 76-84 hyaluronan synthase 1 Homo sapiens 202-207 20013120-7 2010 Compared to GABA used as pure chemical compound, the up-regulation HBD-2 was similar while the effect on the expression of HAS1 and FGR genes was higher. gamma-Aminobutyric Acid 12-16 hyaluronan synthase 1 Homo sapiens 123-127 19737932-2 2009 In mammals, HA is synthesized by three homologous HA synthases, HAS1, HAS2, and HAS3, that polymerize the HA chain using UDP-glucuronic acid and UDP-N-acetylglucosamine as precursors. Uridine Diphosphate Glucuronic Acid 121-140 hyaluronan synthase 1 Homo sapiens 64-68 19737932-2 2009 In mammals, HA is synthesized by three homologous HA synthases, HAS1, HAS2, and HAS3, that polymerize the HA chain using UDP-glucuronic acid and UDP-N-acetylglucosamine as precursors. Uridine Diphosphate N-Acetylglucosamine 145-168 hyaluronan synthase 1 Homo sapiens 64-68 19633293-7 2009 Chromatin immunoprecipitation, using a cAMP-responsive element-binding protein antibody, of db-cAMP-treated preadipocytes (n = 4) yielded products for HAS1 and HAS2 with relative fold increases of 3.3 +/- 0.8 and 2.6 +/- 0.9, respectively. Bucladesine 92-99 hyaluronan synthase 1 Homo sapiens 151-155 19248106-7 2009 RESULTS: CS increased HA production by FLS through up-regulation of the expression of HAS1 and HAS2. Chondroitin Sulfates 9-11 hyaluronan synthase 1 Homo sapiens 86-90 19633293-4 2009 Preadipocytes (n = 8) treated with dibutyryl (db)-cAMP display significantly increased HAS1 and HAS2 transcripts, HAS2 protein, and HA production (p < 0.02). dibutyryl (db)- 35-50 hyaluronan synthase 1 Homo sapiens 87-91 19633293-4 2009 Preadipocytes (n = 8) treated with dibutyryl (db)-cAMP display significantly increased HAS1 and HAS2 transcripts, HAS2 protein, and HA production (p < 0.02). Cyclic AMP 50-54 hyaluronan synthase 1 Homo sapiens 87-91 19633293-5 2009 HAS1 or HAS2 small interfering RNA treatment of db-cAMP-stimulated preadipocytes (n = 4) produced 80% knockdown in HAS1 or 61% knockdown in HAS2 transcripts (compared with scrambled), respectively; the corresponding HA production was reduced by 49 or 38%. Bucladesine 48-55 hyaluronan synthase 1 Homo sapiens 0-4 19633293-5 2009 HAS1 or HAS2 small interfering RNA treatment of db-cAMP-stimulated preadipocytes (n = 4) produced 80% knockdown in HAS1 or 61% knockdown in HAS2 transcripts (compared with scrambled), respectively; the corresponding HA production was reduced by 49 or 38%. Bucladesine 48-55 hyaluronan synthase 1 Homo sapiens 115-119 19633293-6 2009 Reporter assays using A293 cells transfected with HAS1 promoter-driven plasmids containing or not containing the proximal CRE and treated with db-cAMP revealed that it is functional. Bucladesine 143-150 hyaluronan synthase 1 Homo sapiens 50-54 21977277-1 2009 The hyaluronan synthase 1 (HAS-1) gene encodes a plasma membrane protein that synthesizes hyaluronan (HA), an extracellular matrix molecule. Hyaluronic Acid 4-14 hyaluronan synthase 1 Homo sapiens 27-32 19435493-0 2009 Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYAL1 and hyaluronan content. Hyaluronic Acid 14-24 hyaluronan synthase 1 Homo sapiens 36-42 19338584-2 2009 Furthermore, COX2-dependent synthesis of prostaglandins (PGs) stimulates HA synthase-1 (HAS1) and HAS2 mRNA expression, together with HA synthesis via the cAMP/protein kinase A pathway in vascular smooth muscle cells. Prostaglandins 57-60 hyaluronan synthase 1 Homo sapiens 73-86 19338584-2 2009 Furthermore, COX2-dependent synthesis of prostaglandins (PGs) stimulates HA synthase-1 (HAS1) and HAS2 mRNA expression, together with HA synthesis via the cAMP/protein kinase A pathway in vascular smooth muscle cells. Prostaglandins 57-60 hyaluronan synthase 1 Homo sapiens 88-92 19248106-14 2009 CONCLUSION: CS stimulates the synthesis of high molecular weight HA in OA FLS through up-regulation of HAS1 and HAS2. Chondroitin Sulfates 12-14 hyaluronan synthase 1 Homo sapiens 103-107 18400745-0 2008 Hyaluronan production in synoviocytes as a consequence of viral infections: HAS1 activation by Epstein-Barr virus and synthetic double- and single-stranded viral RNA analogs. Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 76-80 19348124-5 2009 Protection of fibroblasts from injury induced by exposure to reactive oxygen species was significantly increased by TGF1beta and was associated with increased gene expression and protein formation of HAS1 and HAS2 enzymes synthesising high-molecular-weight HA. Reactive Oxygen Species 61-84 hyaluronan synthase 1 Homo sapiens 200-204 18768572-5 2008 A significant increase in the expression of hyaluronic acid (HA) was detected in IPAH lungs, associated with increased hyaluronan synthase (Has)1 and decreased hyaluronoglucosaminidase 1 gene expression, as assessed by quantitative RT-PCR and Western blotting. Hyaluronic Acid 44-59 hyaluronan synthase 1 Homo sapiens 119-145 18768572-5 2008 A significant increase in the expression of hyaluronic acid (HA) was detected in IPAH lungs, associated with increased hyaluronan synthase (Has)1 and decreased hyaluronoglucosaminidase 1 gene expression, as assessed by quantitative RT-PCR and Western blotting. Hyaluronic Acid 61-63 hyaluronan synthase 1 Homo sapiens 119-145 18768572-6 2008 HAS1 protein localised to PASMC in vivo and increased HA deposition was observed in remodelled pulmonary arteries in IPAH. pasmc 26-31 hyaluronan synthase 1 Homo sapiens 0-4 18768572-8 2008 The results demonstrate an increased hyaluronic acid content in idiopathic pulmonary arterial hypertension lungs, associated with increased hyaluronan synthase 1 and decreased hyaluronoglucosaminidase 1 gene expression. Hyaluronic Acid 37-52 hyaluronan synthase 1 Homo sapiens 140-161 18400745-8 2008 As to the mechanism of virus-induced HAS1 transcription, data are presented that imply that among the double- and single-stranded polynucleotides tested, homopolymeric polycytidylic structures are the most potent inducers of HAS1 transcription and HA release, whereas homopolymeric polyinosinic acid is without effect. Polynucleotides 130-145 hyaluronan synthase 1 Homo sapiens 37-41 19338584-2 2009 Furthermore, COX2-dependent synthesis of prostaglandins (PGs) stimulates HA synthase-1 (HAS1) and HAS2 mRNA expression, together with HA synthesis via the cAMP/protein kinase A pathway in vascular smooth muscle cells. Prostaglandins 41-55 hyaluronan synthase 1 Homo sapiens 73-86 19338584-2 2009 Furthermore, COX2-dependent synthesis of prostaglandins (PGs) stimulates HA synthase-1 (HAS1) and HAS2 mRNA expression, together with HA synthesis via the cAMP/protein kinase A pathway in vascular smooth muscle cells. Prostaglandins 41-55 hyaluronan synthase 1 Homo sapiens 88-92 17721609-6 2007 Human VSMC upregulate HAS1 and HAS2 in response to prostaglandins via Gs-coupled prostaglandin receptor subtypes IP and EP2. Prostaglandins 51-65 hyaluronan synthase 1 Homo sapiens 22-26 18400745-8 2008 As to the mechanism of virus-induced HAS1 transcription, data are presented that imply that among the double- and single-stranded polynucleotides tested, homopolymeric polycytidylic structures are the most potent inducers of HAS1 transcription and HA release, whereas homopolymeric polyinosinic acid is without effect. Poly I 282-299 hyaluronan synthase 1 Homo sapiens 37-41 16861292-4 2006 Interestingly, the cAMP response to adenosine generated from 5"-AMP via CD73 and the ability of 5"-AMP to induce hyaluronan synthase 1 mRNA were significantly decreased by the pre-treatment of fibroblasts with Jurkat cell lysate. Adenosine Monophosphate 96-102 hyaluronan synthase 1 Homo sapiens 113-134 16904269-0 2007 Prostaglandin E2: a potent activator of hyaluronan synthase 1 in type-B-synoviocytes. Dinoprostone 0-16 hyaluronan synthase 1 Homo sapiens 40-61 16904269-3 2007 We tested a series of eicosanoids and demonstrate that PGE(2) is a very potent activator of HAS1 in synoviocytes. Eicosanoids 22-33 hyaluronan synthase 1 Homo sapiens 92-96 16904269-3 2007 We tested a series of eicosanoids and demonstrate that PGE(2) is a very potent activator of HAS1 in synoviocytes. Dinoprostone 55-61 hyaluronan synthase 1 Homo sapiens 92-96 16904269-4 2007 While mumol concentrations of PGI(2) are required to activate HAS1, low nmol concentrations of PGE(2) are sufficient. Epoprostenol 30-36 hyaluronan synthase 1 Homo sapiens 62-66 16904269-5 2007 In addition, while two thromboxane A(2) analogs moderately activated HAS1 at higher concentrations, the lipoxygenase pathway product LTB(4) was without effect. thromboxane a 23-36 hyaluronan synthase 1 Homo sapiens 69-73 16904269-7 2007 Similarly, sodium salicylate (NaSal) also suppressed IL-1beta induced HAS1 activation. Sodium Salicylate 11-28 hyaluronan synthase 1 Homo sapiens 70-74 16904269-9 2007 PGE(2) is a very powerful activator of HAS1 transcription and translation. Dinoprostone 0-6 hyaluronan synthase 1 Homo sapiens 39-43 16904269-10 2007 Such data indicate that the effect of IL-1beta on HAS1 is mediated by prostaglandins. Prostaglandins 70-84 hyaluronan synthase 1 Homo sapiens 50-54 16339488-8 2006 HAS2, HAS1, and HA synthesis were strongly induced by vasodilatory prostaglandins via Gs-coupled prostaglandin receptors. Prostaglandins 67-81 hyaluronan synthase 1 Homo sapiens 6-10 16603733-1 2006 The linear glycosaminoglycan hyaluronan (HA) is synthesized at the plasma membrane by the HA synthase (HAS) enzymes HAS1, -2, and -3 and performs multiple functions as part of the vertebrate extracellular matrix. glycosaminoglycan hyaluronan 11-39 hyaluronan synthase 1 Homo sapiens 116-132 16603733-1 2006 The linear glycosaminoglycan hyaluronan (HA) is synthesized at the plasma membrane by the HA synthase (HAS) enzymes HAS1, -2, and -3 and performs multiple functions as part of the vertebrate extracellular matrix. Hyaluronic Acid 41-43 hyaluronan synthase 1 Homo sapiens 116-132 16522194-2 2006 Hyaluronan is synthesized by three homologous hyaluronan synthases designated HAS1, HAS2 and HAS3 that differ in their tissue distribution, regulation and enzymatic characteristics. Hyaluronic Acid 0-10 hyaluronan synthase 1 Homo sapiens 78-82 16723203-0 2006 The NF-kappaB inhibitor pyrrolidine dithiocarbamate blocks IL-1beta induced hyaluronan synthase 1 (HAS1) mRNA transcription, pointing at NF-kappaB dependence of the gene HAS1. pyrrolidine dithiocarbamic acid 24-51 hyaluronan synthase 1 Homo sapiens 76-97 16723203-0 2006 The NF-kappaB inhibitor pyrrolidine dithiocarbamate blocks IL-1beta induced hyaluronan synthase 1 (HAS1) mRNA transcription, pointing at NF-kappaB dependence of the gene HAS1. pyrrolidine dithiocarbamic acid 24-51 hyaluronan synthase 1 Homo sapiens 99-103 16723203-0 2006 The NF-kappaB inhibitor pyrrolidine dithiocarbamate blocks IL-1beta induced hyaluronan synthase 1 (HAS1) mRNA transcription, pointing at NF-kappaB dependence of the gene HAS1. pyrrolidine dithiocarbamic acid 24-51 hyaluronan synthase 1 Homo sapiens 170-174 16723203-6 2006 Pyrrolidine dithiocarbamate (PDTC) blocks IL-1beta induced HAS1 activation entirely. pyrrolidine dithiocarbamic acid 0-27 hyaluronan synthase 1 Homo sapiens 59-63 16723203-6 2006 Pyrrolidine dithiocarbamate (PDTC) blocks IL-1beta induced HAS1 activation entirely. pyrrolidine dithiocarbamic acid 29-33 hyaluronan synthase 1 Homo sapiens 59-63