PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
15831491-0	2005	Small GTPase proteins Rin and Rit Bind to PAR6 GTP-dependently and regulate cell transformation.	Guanosine Triphosphate	6-9	Ras-like without CAAX 2	Mus musculus	22-25
17440073-0	2007	SAG/ROC2/Rbx2 is a novel activator protein-1 target that promotes c-Jun degradation and inhibits 12-O-tetradecanoylphorbol-13-acetate-induced neoplastic transformation.	Tetradecanoylphorbol Acetate	97-133	Ras-like without CAAX 2	Mus musculus	4-8
15831491-3	2005	Here we showed that Rin and Rit directly bind to the PDZ domain of PAR6, a cell polarity-regulating protein, in a GTP-dependent manner both in vivo and in vitro.	Guanosine Triphosphate	114-117	Ras-like without CAAX 2	Mus musculus	20-23
18513186-8	2008	Sucrose density gradient cell fractionation revealed membrane association of the dominant 50 kDa variant in HepG2 and Rin-5F cells.	Sucrose	0-7	Ras-like without CAAX 2	Mus musculus	118-121
11032018-1	2000	The biological functions of Rit (Ras-like protein in tissues) and Rin (Ras-like protein in neurons), members of a novel branch of Ras-related GTP-binding proteins that are approximately 50% identical to Ras, have not been characterized.	Guanosine Triphosphate	142-145	Ras-like without CAAX 2	Mus musculus	66-69
34471250-10	2021	Importantly, we found that Rit2 is required for AMPH-stimulated DAT internalization in mouse striatum, and that DAergic RicQ117L expression significantly increased Drosophila AMPH sensitivity in a DAT-dependent manner, suggesting a conserved impact of Ric-dependent DAT trafficking on AMPH sensitivity.	Amphetamine	48-52	Ras-like without CAAX 2	Mus musculus	27-31
34471250-10	2021	Importantly, we found that Rit2 is required for AMPH-stimulated DAT internalization in mouse striatum, and that DAergic RicQ117L expression significantly increased Drosophila AMPH sensitivity in a DAT-dependent manner, suggesting a conserved impact of Ric-dependent DAT trafficking on AMPH sensitivity.	Amphetamine	285-289	Ras-like without CAAX 2	Mus musculus	27-31
34471250-11	2021	These studies support that the DAT/Rit2 interaction impacts both baseline behaviors and AMPH sensitivity, potentially by regulating DAT trafficking.	Amphetamine	88-92	Ras-like without CAAX 2	Mus musculus	35-39
31277075-0	2020	Conditional, inducible gene silencing in dopamine neurons reveals a sex-specific role for Rit2 GTPase in acute cocaine response and striatal function.	Dopamine	41-49	Ras-like without CAAX 2	Mus musculus	90-94
31277075-0	2020	Conditional, inducible gene silencing in dopamine neurons reveals a sex-specific role for Rit2 GTPase in acute cocaine response and striatal function.	Cocaine	111-118	Ras-like without CAAX 2	Mus musculus	90-94
31277075-4	2020	Here we leveraged the TET-OFF system to conditionally silence Rit2 in Pitx3IRES2-tTA mouse DANs.	tetramethylenedisulfotetramine	22-25	Ras-like without CAAX 2	Mus musculus	62-66
31277075-6	2020	Further, males exhibited increased acute cocaine sensitivity, whereas DAergic Rit2-KD suppressed acute cocaine sensitivity in females.	Cocaine	103-110	Ras-like without CAAX 2	Mus musculus	78-82
31277075-11	2020	Moreover, DAergic Rit2-KD abolished the ability of cocaine to reduce sEPSP frequency in D1+, but not D2+, male MSNs.	Cocaine	51-58	Ras-like without CAAX 2	Mus musculus	18-22
31860682-0	2019	N-acetyl cysteine attenuates oxidative stress and glutathione-dependent redox imbalance caused by high glucose/high palmitic acid treatment in pancreatic Rin-5F cells.	Acetylcysteine	0-17	Ras-like without CAAX 2	Mus musculus	154-157
31860682-0	2019	N-acetyl cysteine attenuates oxidative stress and glutathione-dependent redox imbalance caused by high glucose/high palmitic acid treatment in pancreatic Rin-5F cells.	Glutathione	50-61	Ras-like without CAAX 2	Mus musculus	154-157
31860682-0	2019	N-acetyl cysteine attenuates oxidative stress and glutathione-dependent redox imbalance caused by high glucose/high palmitic acid treatment in pancreatic Rin-5F cells.	Glucose	103-110	Ras-like without CAAX 2	Mus musculus	154-157
31860682-0	2019	N-acetyl cysteine attenuates oxidative stress and glutathione-dependent redox imbalance caused by high glucose/high palmitic acid treatment in pancreatic Rin-5F cells.	Palmitic Acid	116-129	Ras-like without CAAX 2	Mus musculus	154-157
31860682-5	2019	The aim of the present work was to elucidate the molecular mechanisms of oxidative stress, and inflammatory/antioxidant responses in the presence of high concentrations of glucose/fatty acids in a cell-culture system using an insulin-secreting pancreatic beta-cell line (Rin-5F) and to study the effects of the antioxidant, N-acetyl cysteine (NAC) on beta-cell toxicity.	Glucose	172-179	Ras-like without CAAX 2	Mus musculus	271-274
31860682-5	2019	The aim of the present work was to elucidate the molecular mechanisms of oxidative stress, and inflammatory/antioxidant responses in the presence of high concentrations of glucose/fatty acids in a cell-culture system using an insulin-secreting pancreatic beta-cell line (Rin-5F) and to study the effects of the antioxidant, N-acetyl cysteine (NAC) on beta-cell toxicity.	Fatty Acids	180-191	Ras-like without CAAX 2	Mus musculus	271-274
31860682-6	2019	In our study, we investigated the molecular mechanism of cytotoxicity in the presence of high glucose (up to 25 mM) and high palmitic acid (up to 0.3 mM) on Rin-5F cells.	Glucose	94-101	Ras-like without CAAX 2	Mus musculus	157-160
31860682-6	2019	In our study, we investigated the molecular mechanism of cytotoxicity in the presence of high glucose (up to 25 mM) and high palmitic acid (up to 0.3 mM) on Rin-5F cells.	Palmitic Acid	125-138	Ras-like without CAAX 2	Mus musculus	157-160
20638939-0	2010	Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kappaB activation in mouse embryonic stem cells.	ros	69-72	Ras-like without CAAX 2	Mus musculus	23-27
20638939-1	2010	SAG (sensitive to apoptosis gene; also known as RBX2 or ROC2) is a dual-function protein with antioxidant activity when acting alone or E3 ligase activity when complexed with other components of SCF (Skp1, cullins, F-box proteins) E3 ubiquitin ligases.	sagopilone	0-3	Ras-like without CAAX 2	Mus musculus	56-60
17426113-7	2007	Dexamethasone treatment of Rin-5F cells resulted in an increased secretagogin release rate, which was inversely correlated with insulin secretion.	Dexamethasone	0-13	Ras-like without CAAX 2	Mus musculus	27-30
17426113-13	2007	The effects of dexamethasone on the total secretagogin content in Rin-5F cells and on its intracellular distribution might result in an impaired Ca(2+) sensitivity of dexamethasone-treated insulin-secreting cells.	Dexamethasone	15-28	Ras-like without CAAX 2	Mus musculus	66-69
17426113-13	2007	The effects of dexamethasone on the total secretagogin content in Rin-5F cells and on its intracellular distribution might result in an impaired Ca(2+) sensitivity of dexamethasone-treated insulin-secreting cells.	Dexamethasone	167-180	Ras-like without CAAX 2	Mus musculus	66-69