PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
29739902-5	2018	Furthermore, cytarabine inhibited viral DNA and RNA syntheses and induced the rapid degradation of KSHV major latent protein LANA (latency-associated nuclear antigen), leading to the suppression of KSHV latent replication.	Cytarabine	13-23	LANA	Human gammaherpesvirus 8	125-129
29739902-5	2018	Furthermore, cytarabine inhibited viral DNA and RNA syntheses and induced the rapid degradation of KSHV major latent protein LANA (latency-associated nuclear antigen), leading to the suppression of KSHV latent replication.	Cytarabine	13-23	LANA	Human gammaherpesvirus 8	131-165
29739902-13	2018	Of interest, cytarabine induced the degradation of KSHV major latent protein LANA, hence suppressing KSHV latent replication, which is required for PEL cell survival.	Cytarabine	13-23	LANA	Human gammaherpesvirus 8	77-81
28099521-5	2017	Here, we found that KSHV-encoded LANA interacts with STAT6 and promotes nuclear localization of STAT6 independent of the tyrosine 641-phosphorylation state.	Tyrosine	121-129	LANA	Human gammaherpesvirus 8	33-37
28850829-3	2017	Here we show that LANA homologs of macaque RRV and MneRV2 from the more distantly-related RV2 lineage, lack the KR-rich NLS, and instead have a large RG-rich NLS with multiple RG dipeptides and a conserved RGG motif.	Dipeptides	179-189	LANA	Human gammaherpesvirus 8	18-22
28978712-3	2017	Using highly sensitive tyramide signal amplification, we determined that LANA localizes to the cytoplasm in different cell types undergoing the lytic cycle of replication after de novo primary infection and after spontaneous, tetradecanoyl phorbol acetate-, or open reading frame 50 (ORF50)/replication transactivator (RTA)-induced activation.	tyramide	23-31	LANA	Human gammaherpesvirus 8	73-77
28978712-3	2017	Using highly sensitive tyramide signal amplification, we determined that LANA localizes to the cytoplasm in different cell types undergoing the lytic cycle of replication after de novo primary infection and after spontaneous, tetradecanoyl phorbol acetate-, or open reading frame 50 (ORF50)/replication transactivator (RTA)-induced activation.	Tetradecanoylphorbol Acetate	226-255	LANA	Human gammaherpesvirus 8	73-77
24972086-5	2014	DNA profile of LANA expressing human B-cells demonstrated the ability of this nuclear antigen in relieving the drug (Nocodazole) induced G2/M checkpoint arrest.	Nocodazole	117-127	LANA	Human gammaherpesvirus 8	15-19
26218605-3	2015	We found that exposure of KSHV-infected cells to oxidative stress, or other inducers of apoptosis and caspase activation, led to processing of LANA and that this processing could be inhibited with the pan-caspase inhibitor Z-VAD-FMK.	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	223-232	LANA	Human gammaherpesvirus 8	143-147
26218605-7	2015	Using peptides spanning the identified LANA cleavage sites, we show that caspase activity can be inhibited in vitro and that a cell-permeable peptide spanning the C-terminal cleavage site could inhibit cleavage of poly (ADP-ribose) polymerase and increase viability in cells undergoing etoposide-induced apoptosis.	Etoposide	286-295	LANA	Human gammaherpesvirus 8	39-43
27736870-12	2016	Interestingly, genipin treatment at a lower concentration did induce the expression of DNA (cytosine-5)-methyltransferase 1 (DNMT1); however, a co-immunoprecipitation assay showed that the DNMT1 and LANA induced by genipin did not co-precipitate from iSLK-BAC16 cells.	genipin	15-22	LANA	Human gammaherpesvirus 8	199-203
26420481-6	2015	As expected, LANA mutants with alanine or glutamate substitutions in the central, peripheral, or lateral portions of the positive patch maintained the ability to bind DNA by EMSA.	Alanine	31-38	LANA	Human gammaherpesvirus 8	13-17
26420481-6	2015	As expected, LANA mutants with alanine or glutamate substitutions in the central, peripheral, or lateral portions of the positive patch maintained the ability to bind DNA by EMSA.	Glutamic Acid	42-51	LANA	Human gammaherpesvirus 8	13-17
25947153-9	2015	Moreover, we show that the LANA DBD can coat DNA of arbitrary sequence by virtue of a characteristic lysine patch, which is absent in EBNA-1 of the Epstein-Barr virus.	Lysine	101-107	LANA	Human gammaherpesvirus 8	27-31
26191531-8	2015	Dual label immunohistochemistry on formalin-fixed paraffin-embedded tumor tissue revealed reduced expression of tropoelastin in LANA positive spindle cell regions quantified by Ariol SL-50 scanning analysis.	Formaldehyde	35-43	LANA	Human gammaherpesvirus 8	128-132
26191531-8	2015	Dual label immunohistochemistry on formalin-fixed paraffin-embedded tumor tissue revealed reduced expression of tropoelastin in LANA positive spindle cell regions quantified by Ariol SL-50 scanning analysis.	Paraffin	50-58	LANA	Human gammaherpesvirus 8	128-132
24146614-7	2013	Opposite to the DNA binding site, both kLANA and mLANA CTD contain a characteristic lysine-rich positively charged surface patch, which appears to be a unique feature of gamma2-herpesviral LANA proteins.	Lysine	84-90	LANA	Human gammaherpesvirus 8	40-44
24278015-3	2013	Here, we report that LANA encoded by KSHV contains a unique SUMO-interacting motif (LANA(SIM)) which is specific for interaction with SUMO-2 and facilitates LANA SUMOylation at lysine 1140.	Lysine	177-183	LANA	Human gammaherpesvirus 8	21-25
24278015-3	2013	Here, we report that LANA encoded by KSHV contains a unique SUMO-interacting motif (LANA(SIM)) which is specific for interaction with SUMO-2 and facilitates LANA SUMOylation at lysine 1140.	Lysine	177-183	LANA	Human gammaherpesvirus 8	84-88
24278015-3	2013	Here, we report that LANA encoded by KSHV contains a unique SUMO-interacting motif (LANA(SIM)) which is specific for interaction with SUMO-2 and facilitates LANA SUMOylation at lysine 1140.	Lysine	177-183	LANA	Human gammaherpesvirus 8	84-88
22179613-4	2012	The major arginine methylation site in LANA was mapped to arginine 20.	Arginine	10-18	LANA	Human gammaherpesvirus 8	39-43
22761383-8	2012	TopoIIbeta plays an important role in LANA-dependent latent DNA replication, as addition of ellipticine, a selective inhibitor of TopoII, negatively regulated replication mediated by the TR.	ellipticine	92-103	LANA	Human gammaherpesvirus 8	38-42
22179613-3	2012	Here, we report that LANA is subject to arginine methylation by protein arginine methyltransferase 1 in vitro and in vivo.	Arginine	40-48	LANA	Human gammaherpesvirus 8	21-25
22179613-4	2012	The major arginine methylation site in LANA was mapped to arginine 20.	Arginine	58-66	LANA	Human gammaherpesvirus 8	39-43
22179613-10	2012	These results suggest that residue 20 is important for modulation of a subset of LANA functions and properties of this residue, including the hydrophobic character induced by arginine methylation, may contribute to the observed effects.	Arginine	175-183	LANA	Human gammaherpesvirus 8	81-85
19266083-8	2009	Furthermore, our data indicate that Pim-1 and Pim-3 contribute to viral reactivation by phosphorylating the KSHV latency-associated nuclear antigen (LANA) on serine residues 205 and 206.	Serine	158-164	LANA	Human gammaherpesvirus 8	149-153
23093938-7	2012	Alanine mutations of serine 10 and threonine 14 abolish or severely diminish chromatin and histone binding by LANA.	Threonine	35-44	LANA	Human gammaherpesvirus 8	110-114
23093938-8	2012	However, conversion of these residues to the phosphomimetic glutamic acid restored histone binding suggesting that phosphorylation of serine 10 and threonine 14 may modulate LANA function.	Glutamic Acid	60-73	LANA	Human gammaherpesvirus 8	174-178
23093938-8	2012	However, conversion of these residues to the phosphomimetic glutamic acid restored histone binding suggesting that phosphorylation of serine 10 and threonine 14 may modulate LANA function.	Serine	134-140	LANA	Human gammaherpesvirus 8	174-178
23093938-8	2012	However, conversion of these residues to the phosphomimetic glutamic acid restored histone binding suggesting that phosphorylation of serine 10 and threonine 14 may modulate LANA function.	Threonine	148-157	LANA	Human gammaherpesvirus 8	174-178
20032179-2	2010	Performance of these diverse functions involves a 7-amino-acid chromatin-binding motif (CBM) situated at the amino terminus of LANA that is capable of binding directly to nucleosomes.	7-amino-acid	50-62	LANA	Human gammaherpesvirus 8	127-131
19225000-6	2009	Alanine substitutions for LANA residues (1068)LKK(1070) and (1125)SHP(1127) severely impaired chromosome binding but did not reduce the other C-terminal LANA functions of self-association or DNA binding.	Alanine	0-7	LANA	Human gammaherpesvirus 8	26-30
21559489-6	2011	Our studies revealed that both LANA proteins contain an N-terminal arginine/glycine (RG)-rich domain spanning a conserved chromatin-binding motif, which binds directly to importin beta1 in a RanGTP-sensitive manner and serves as an NLS in the importin beta1-mediated non-classical nuclear import pathway.	Arginine	67-75	LANA	Human gammaherpesvirus 8	31-35
21559489-6	2011	Our studies revealed that both LANA proteins contain an N-terminal arginine/glycine (RG)-rich domain spanning a conserved chromatin-binding motif, which binds directly to importin beta1 in a RanGTP-sensitive manner and serves as an NLS in the importin beta1-mediated non-classical nuclear import pathway.	Glycine	76-83	LANA	Human gammaherpesvirus 8	31-35
20660191-8	2010	Moreover, LANA associated with another kinetochore protein, Bub1 (budding uninhibited by benzimidazole 1), which is known to form a complex with CENP-F.	benzimidazole	89-102	LANA	Human gammaherpesvirus 8	10-14
17314169-3	2007	In the present study, the nuclear GSK-3 bound to LANA in transfected cells and in BCBL1 primary effusion lymphoma cells was found to be enriched for the inactive serine 9-phosphorylated form of GSK-3.	Serine	162-168	LANA	Human gammaherpesvirus 8	49-53
16861237-6	2006	From the results of binding assays, a region containing the Glu/Asp-rich domain within LANA, and a central region including the second paired amphipathic helix within Daxx contributed to the interaction.	Glutamic Acid	60-63	LANA	Human gammaherpesvirus 8	87-91
17364023-5	2007	Our results demonstrated that the KSHV latency-associated nuclear antigen (LANA) bound to both p53 and MDM2 and that the MDM2 inhibitor Nutlin-3a disrupted the p53-MDM2-LANA complex and selectively induced massive apoptosis in PEL cells.	nutlin 3	136-145	LANA	Human gammaherpesvirus 8	75-79
17364023-5	2007	Our results demonstrated that the KSHV latency-associated nuclear antigen (LANA) bound to both p53 and MDM2 and that the MDM2 inhibitor Nutlin-3a disrupted the p53-MDM2-LANA complex and selectively induced massive apoptosis in PEL cells.	nutlin 3	136-145	LANA	Human gammaherpesvirus 8	169-173
16879850-3	2006	RFHVMn LANA is structurally analogous to KSHV ORF73 LANA and contains an N-terminal serine-proline-rich region, a large internal glutamic acidic-rich repeat region and a conserved C-terminal domain.	Serine	84-90	LANA	Human gammaherpesvirus 8	7-11
16879850-3	2006	RFHVMn LANA is structurally analogous to KSHV ORF73 LANA and contains an N-terminal serine-proline-rich region, a large internal glutamic acidic-rich repeat region and a conserved C-terminal domain.	Proline	91-98	LANA	Human gammaherpesvirus 8	7-11
16879850-4	2006	RFHVMn LANA reacts with monoclonal antibodies specific for a glutamic acid-proline dipeptide motif and a glutamic acid-glutamine-rich motif in the KSHV LANA repeat region.	glutamic acid-proline	61-82	LANA	Human gammaherpesvirus 8	7-11
16879850-4	2006	RFHVMn LANA reacts with monoclonal antibodies specific for a glutamic acid-proline dipeptide motif and a glutamic acid-glutamine-rich motif in the KSHV LANA repeat region.	Dipeptides	83-92	LANA	Human gammaherpesvirus 8	7-11
16879850-4	2006	RFHVMn LANA reacts with monoclonal antibodies specific for a glutamic acid-proline dipeptide motif and a glutamic acid-glutamine-rich motif in the KSHV LANA repeat region.	Glutamic Acid	61-74	LANA	Human gammaherpesvirus 8	7-11
16879850-4	2006	RFHVMn LANA reacts with monoclonal antibodies specific for a glutamic acid-proline dipeptide motif and a glutamic acid-glutamine-rich motif in the KSHV LANA repeat region.	Glutamine	119-128	LANA	Human gammaherpesvirus 8	7-11
16861237-6	2006	From the results of binding assays, a region containing the Glu/Asp-rich domain within LANA, and a central region including the second paired amphipathic helix within Daxx contributed to the interaction.	Aspartic Acid	64-67	LANA	Human gammaherpesvirus 8	87-91
16701788-8	2006	However, latency-associated nuclear antigen (LANA) which is predominantly expressed during latency can specifically down-modulate ICN-mediated transactivation of RTA and so control KSHV for lytic reactivation.	icn	130-133	LANA	Human gammaherpesvirus 8	9-43
16873253-0	2006	Kaposi"s sarcoma-associated herpesvirus latent protein LANA interacts with HIF-1 alpha to upregulate RTA expression during hypoxia: Latency control under low oxygen conditions.	Oxygen	158-164	LANA	Human gammaherpesvirus 8	55-59
16873253-3	2006	Here we show that the latency-associated nuclear antigen (LANA), which plays a crucial role in modulating viral and cellular gene expression, directly associated with a low oxygen responder, hypoxia-inducible factor-1 alpha (HIF-1 alpha).	Oxygen	173-179	LANA	Human gammaherpesvirus 8	58-62
16701788-8	2006	However, latency-associated nuclear antigen (LANA) which is predominantly expressed during latency can specifically down-modulate ICN-mediated transactivation of RTA and so control KSHV for lytic reactivation.	icn	130-133	LANA	Human gammaherpesvirus 8	45-49
15525642-5	2005	To investigate this question, we generated an Epstein-Barr virus-negative Burkitts lymphoma line that expresses LANA from a tetracycline-inducible promoter (BJAB/Tet-On/LANA), and we performed microarray-based gene expression profiling.	Tetracycline	124-136	LANA	Human gammaherpesvirus 8	112-116
16699007-7	2006	Histone deacetylase inhibitors, including sodium butyrate (NaB) and trichostatin A, caused the rapid dissociation of LANA from the ORF50 promoter.	Butyric Acid	42-57	LANA	Human gammaherpesvirus 8	117-121
16699007-7	2006	Histone deacetylase inhibitors, including sodium butyrate (NaB) and trichostatin A, caused the rapid dissociation of LANA from the ORF50 promoter.	nab	59-62	LANA	Human gammaherpesvirus 8	117-121
16699007-7	2006	Histone deacetylase inhibitors, including sodium butyrate (NaB) and trichostatin A, caused the rapid dissociation of LANA from the ORF50 promoter.	trichostatin A	68-82	LANA	Human gammaherpesvirus 8	117-121
16699007-8	2006	NaB treatment of latently infected BCBL1 cells disrupted a stable interaction between LANA and the cellular proteins Sp1 and histone H2B.	nab	0-3	LANA	Human gammaherpesvirus 8	86-90
16699007-9	2006	We also found immunological and radiochemical evidence that LANA is subject to lysine acetylation after NaB treatment.	Lysine	79-85	LANA	Human gammaherpesvirus 8	60-64
16699007-9	2006	We also found immunological and radiochemical evidence that LANA is subject to lysine acetylation after NaB treatment.	nab	104-107	LANA	Human gammaherpesvirus 8	60-64
15765147-7	2005	We show that reduced levels of LANA lead to p53 reactivation, an increase in ROS, and mitochondrial dysfunction, which result in G1 cell cycle arrest, DNA fragmentation, and oxidative stress-mediated apoptosis.	ros	77-80	LANA	Human gammaherpesvirus 8	31-35
16699007-10	2006	These findings support the role of LANA as a transcriptional repressor of lytic reactivation and provide evidence that lysine acetylation regulates LANA interactions with chromatin, Sp1, and ORF50 promoter DNA.	Lysine	119-125	LANA	Human gammaherpesvirus 8	148-152
16051824-15	2005	Analyses of viral gene expression by quantitative real-time reverse transcriptase PCR revealed that pretreatment of cells with U0126 for 1 h and during the 2-h infection with KSHV significantly inhibited the expression of ORF 73, ORF 50 (RTA), and the IE-K8 and v-IRF2 genes.	U 0126	127-132	LANA	Human gammaherpesvirus 8	222-228
16051824-17	2005	Expression of ORF 73 in BCBL-1 cells was also significantly inhibited by preincubation with U0126.	U 0126	92-97	LANA	Human gammaherpesvirus 8	14-20
16051835-7	2005	Phosphorylation of endogenous LANA precipitated from primary effusion lymphoma cells was inhibited by the GSK-3 inhibitor LiCl.	Lithium Chloride	122-126	LANA	Human gammaherpesvirus 8	30-34
15220403-5	2004	Here, we found that LANA interacts with SUV39H1 histone methyltransferase, a key component of heterochromatin formation, as determined by use of a DNA pull-down assay with a biotinylated DNA fragment that contained a LANA-specific binding sequence and a maltose-binding protein pull-down assay.	Maltose	254-261	LANA	Human gammaherpesvirus 8	20-24
15166417-5	2004	The protein expressed from this transcript is representative of the faster migration of the LANA doublet bands observed by SDS-PAGE and Western blot.	Sodium Dodecyl Sulfate	123-126	LANA	Human gammaherpesvirus 8	92-96
12829841-10	2003	In tetradecanoyl phorbol acetate-treated PEL cells, loss of LANA expression correlated temporally with loss of detectable beta-catenin.	Tetradecanoylphorbol Acetate	3-32	LANA	Human gammaherpesvirus 8	60-64
11533207-8	2001	Moreover, we demonstrated that specific domains of LANA containing the putative leucine zipper and the glutamic acid-rich region are highly effective in upregulating these viral promoters, while the amino-terminal region (435 amino acids) exhibited little or no transactivation activity in our assays.	Glutamic Acid	103-116	LANA	Human gammaherpesvirus 8	51-55
11753987-5	2001	Immunohistochemistry using the catalyzed signal amplification system was employed to detect LANA and p53 on paraffin embedded tissues and the immunofluorescence technique was used on cell lines.	Paraffin	108-116	LANA	Human gammaherpesvirus 8	92-96
10900044-4	2000	DNA sequencing of ORF73 from one KSHV-infected cell line, PK-1, revealed that there were 558 bp (30.2%) deletions and 66 (3.6%) point mutations located mainly in repeat region 2, the glutamine-rich region of ORF73 IRD, compared with ORF73 of BC-1 KSHV.	Glutamine	183-192	LANA	Human gammaherpesvirus 8	18-23
11038375-3	2000	Here, it is reported that LANA interacts with activating transcription factor (ATF) 4/cAMP response element-binding protein (CREB) 2, a member of the ATF/CREB family of transcription factors, and represses the transcriptional activation activity of ATF4/CREB2.	Cyclic AMP	86-90	LANA	Human gammaherpesvirus 8	26-30
10753712-2	2000	Western blot analysis in PEL cell lines (TY-1 and BCBL-1) revealed that the expression of these proteins, except ORF73 (LANA), was induced by tetradecanoylphorbol acetate (TPA) treatment, indicating that these proteins are lytic proteins.	Tetradecanoylphorbol Acetate	142-170	LANA	Human gammaherpesvirus 8	113-118
10753712-2	2000	Western blot analysis in PEL cell lines (TY-1 and BCBL-1) revealed that the expression of these proteins, except ORF73 (LANA), was induced by tetradecanoylphorbol acetate (TPA) treatment, indicating that these proteins are lytic proteins.	Tetradecanoylphorbol Acetate	172-175	LANA	Human gammaherpesvirus 8	113-118