PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
10438528-7	1999	Finally, we have identified a repression domain in hFOG-2 and show that repression is dependent upon the integrity of the mCtBP2 interaction motif Pro-Ile-Asp-Leu-Ser.	prolylisoleucine	147-154	C-terminal binding protein 2	Mus musculus	122-128
10438528-7	1999	Finally, we have identified a repression domain in hFOG-2 and show that repression is dependent upon the integrity of the mCtBP2 interaction motif Pro-Ile-Asp-Leu-Ser.	Aspartic Acid	155-158	C-terminal binding protein 2	Mus musculus	122-128
10438528-7	1999	Finally, we have identified a repression domain in hFOG-2 and show that repression is dependent upon the integrity of the mCtBP2 interaction motif Pro-Ile-Asp-Leu-Ser.	Leucine	159-162	C-terminal binding protein 2	Mus musculus	122-128
10438528-7	1999	Finally, we have identified a repression domain in hFOG-2 and show that repression is dependent upon the integrity of the mCtBP2 interaction motif Pro-Ile-Asp-Leu-Ser.	Serine	163-166	C-terminal binding protein 2	Mus musculus	122-128
32434298-5	2020	Herein, we focus our studies on revealing the in vitro and in vivo effects of a small molecule NSM00158, which showed the strongest inhibition of the CtBP2-p300 interaction in vitro.	nsm00158	95-103	C-terminal binding protein 2	Mus musculus	150-155
9724649-5	1998	mCtBP2 is related to human CtBP, a cellular protein which binds to a Pro-X-Asp-Leu-Ser motif in the C-terminus of the adenoviral oncoprotein, E1a.	pro-x-asp-leu	69-82	C-terminal binding protein 2	Mus musculus	0-6
9724649-5	1998	mCtBP2 is related to human CtBP, a cellular protein which binds to a Pro-X-Asp-Leu-Ser motif in the C-terminus of the adenoviral oncoprotein, E1a.	Serine	83-86	C-terminal binding protein 2	Mus musculus	0-6
35153673-2	2022	Synaptic ribbons are largely composed of RIBEYE, a protein containing an N-terminal A-domain and a carboxyterminal B-domain that is identical with CtBP2, a NAD(H)-binding transcriptional co-repressor.	NAD	156-162	C-terminal binding protein 2	Mus musculus	147-152
31586042-3	2019	A small-molecule inhibitor of CtBP2, 4-chloro-hydroxyimino phenylpyruvate (4-Cl-HIPP) phenocopied Ctbp2 deletion, decreasing tumor burden similarly to gemcitabine, and the combination of 4-Cl-HIPP and gemcitabine further synergistically suppressed tumor growth.	phenylpyruvic acid	37-73	C-terminal binding protein 2	Mus musculus	30-35
32049007-5	2020	Because ablation of CtBP2 abrogates the therapeutic effect of phenformin in mice, these data illustrate a biguanide-mediated redox/corepressor interplay, which may represent a relevant target for tumor therapy.	Phenformin	62-72	C-terminal binding protein 2	Mus musculus	20-25
32049007-5	2020	Because ablation of CtBP2 abrogates the therapeutic effect of phenformin in mice, these data illustrate a biguanide-mediated redox/corepressor interplay, which may represent a relevant target for tumor therapy.	Biguanides	106-115	C-terminal binding protein 2	Mus musculus	20-25
32169478-4	2020	In turn, CtBP2 has been associated with neurodevelopment and neurological disease, and we have shown that CtBP2 acetylation and dimerization, required for proper transcriptional activity, are regulated by microenvironmental oxygen levels.	Oxygen	224-230	C-terminal binding protein 2	Mus musculus	9-14
32169478-4	2020	In turn, CtBP2 has been associated with neurodevelopment and neurological disease, and we have shown that CtBP2 acetylation and dimerization, required for proper transcriptional activity, are regulated by microenvironmental oxygen levels.	Oxygen	224-230	C-terminal binding protein 2	Mus musculus	106-111
31586042-3	2019	A small-molecule inhibitor of CtBP2, 4-chloro-hydroxyimino phenylpyruvate (4-Cl-HIPP) phenocopied Ctbp2 deletion, decreasing tumor burden similarly to gemcitabine, and the combination of 4-Cl-HIPP and gemcitabine further synergistically suppressed tumor growth.	phenylpyruvic acid	37-73	C-terminal binding protein 2	Mus musculus	98-103
31586042-3	2019	A small-molecule inhibitor of CtBP2, 4-chloro-hydroxyimino phenylpyruvate (4-Cl-HIPP) phenocopied Ctbp2 deletion, decreasing tumor burden similarly to gemcitabine, and the combination of 4-Cl-HIPP and gemcitabine further synergistically suppressed tumor growth.	phenylpyruvic acid	75-84	C-terminal binding protein 2	Mus musculus	30-35
31586042-3	2019	A small-molecule inhibitor of CtBP2, 4-chloro-hydroxyimino phenylpyruvate (4-Cl-HIPP) phenocopied Ctbp2 deletion, decreasing tumor burden similarly to gemcitabine, and the combination of 4-Cl-HIPP and gemcitabine further synergistically suppressed tumor growth.	gemcitabine	151-162	C-terminal binding protein 2	Mus musculus	30-35
31586042-3	2019	A small-molecule inhibitor of CtBP2, 4-chloro-hydroxyimino phenylpyruvate (4-Cl-HIPP) phenocopied Ctbp2 deletion, decreasing tumor burden similarly to gemcitabine, and the combination of 4-Cl-HIPP and gemcitabine further synergistically suppressed tumor growth.	phenylpyruvic acid	187-196	C-terminal binding protein 2	Mus musculus	30-35
31586042-3	2019	A small-molecule inhibitor of CtBP2, 4-chloro-hydroxyimino phenylpyruvate (4-Cl-HIPP) phenocopied Ctbp2 deletion, decreasing tumor burden similarly to gemcitabine, and the combination of 4-Cl-HIPP and gemcitabine further synergistically suppressed tumor growth.	gemcitabine	201-212	C-terminal binding protein 2	Mus musculus	30-35
25627828-6	2015	Our research also found ectopic expression of CtBP2 can protect the apoptosis of primary mouse RGC cells induced by L-glutamate.	Glutamic Acid	116-127	C-terminal binding protein 2	Mus musculus	46-51
31036695-6	2019	To better understand the mechanism of action of HIPP-class inhibitors, we investigated the contribution of W324 to CtBP2"s biochemical and physiologic activities utilizing mutational analysis.	w324	107-111	C-terminal binding protein 2	Mus musculus	115-120
31036695-7	2019	Indeed, W324 was necessary for CtBP2 self-association, as shown by analytical ultracentrifugation and in vivo cross-linking.	w324	8-12	C-terminal binding protein 2	Mus musculus	31-36
28438897-10	2017	Interestingly, the ZEB1-CtBP2 complex on negative regulatory element A was significantly upregulated after PMA/ionomycin stimulation in lupus CD4+ T cells.	Ionomycin	111-120	C-terminal binding protein 2	Mus musculus	24-29
26929012-5	2016	Using paired recordings in acute retina slices, we demonstrate that deletion of RIBEYE severely impaired fast and sustained neurotransmitter release at bipolar neuron/AII amacrine cell synapses and rendered spontaneous miniature release sensitive to the slow Ca(2+)-buffer EGTA, suggesting that synaptic ribbons mediate nano-domain coupling of Ca(2+) channels to synaptic vesicle exocytosis.	Egtazic Acid	273-277	C-terminal binding protein 2	Mus musculus	80-86
23775127-0	2013	The corepressor CTBP2 is a coactivator of retinoic acid receptor/retinoid X receptor in retinoic acid signaling.	Tretinoin	42-55	C-terminal binding protein 2	Mus musculus	16-21
24719103-0	2014	ArfGAP3 is a component of the photoreceptor synaptic ribbon complex and forms an NAD(H)-regulated, redox-sensitive complex with RIBEYE that is important for endocytosis.	NAD	81-87	C-terminal binding protein 2	Mus musculus	128-134
24719103-9	2014	ArfGAP3 binds to RIBEYE(B)-domain in an NAD(H)-dependent manner.	NAD	40-46	C-terminal binding protein 2	Mus musculus	17-23
24719103-10	2014	The interaction is redox sensitive because NADH is more efficient than the oxidized NAD(+) in promoting ArfGAP3-RIBEYE interaction.	NAD	43-47	C-terminal binding protein 2	Mus musculus	112-118
24719103-10	2014	The interaction is redox sensitive because NADH is more efficient than the oxidized NAD(+) in promoting ArfGAP3-RIBEYE interaction.	NAD	84-90	C-terminal binding protein 2	Mus musculus	112-118
24719103-11	2014	RIBEYE competes with the GTP-binding protein Arf1 for binding to ArfGAP3.	Guanosine Triphosphate	25-28	C-terminal binding protein 2	Mus musculus	0-6
25170565-0	2014	Changes in the numbers of ribbon synapses and expression of RIBEYE in salicylate-induced tinnitus.	Salicylates	70-80	C-terminal binding protein 2	Mus musculus	60-66
25170565-1	2014	BACKGROUND: This study was performed to explore the mechanism underlying tinnitus by investigating the changes in the synaptic ribbons and RIBEYE expression in cochlear inner hair cells in salicylate-induced tinnitus.	Salicylates	189-199	C-terminal binding protein 2	Mus musculus	139-145
25170565-8	2014	The number of synaptic ribbons in the salicylate group increased on the 7(th) d and decreased on the 9(th) and 10(th) d. mRNA and protein expression of RIBEYE were initially up-regulated and later down-regulated by injecting salicylate for 10 consecutive days.	Salicylates	38-48	C-terminal binding protein 2	Mus musculus	152-158
25170565-8	2014	The number of synaptic ribbons in the salicylate group increased on the 7(th) d and decreased on the 9(th) and 10(th) d. mRNA and protein expression of RIBEYE were initially up-regulated and later down-regulated by injecting salicylate for 10 consecutive days.	Salicylates	225-235	C-terminal binding protein 2	Mus musculus	152-158
25170565-10	2014	The alteration of RIBEYE expression could be responsible for the changes in the morphology of ribbon synapses and for salicylate-induced tinnitus.	Salicylates	118-128	C-terminal binding protein 2	Mus musculus	18-24
23775127-3	2013	Using an RNA interference-based genetic screen in mouse F9 cells, we identified the transcriptional corepressor CTBP2 (C-terminal binding protein 2) as a coactivator critically required for retinoic acid (RA)-induced transcription.	Tretinoin	190-203	C-terminal binding protein 2	Mus musculus	112-117
23775127-3	2013	Using an RNA interference-based genetic screen in mouse F9 cells, we identified the transcriptional corepressor CTBP2 (C-terminal binding protein 2) as a coactivator critically required for retinoic acid (RA)-induced transcription.	Tretinoin	190-203	C-terminal binding protein 2	Mus musculus	119-147
23775127-3	2013	Using an RNA interference-based genetic screen in mouse F9 cells, we identified the transcriptional corepressor CTBP2 (C-terminal binding protein 2) as a coactivator critically required for retinoic acid (RA)-induced transcription.	Tretinoin	205-207	C-terminal binding protein 2	Mus musculus	112-117
23775127-3	2013	Using an RNA interference-based genetic screen in mouse F9 cells, we identified the transcriptional corepressor CTBP2 (C-terminal binding protein 2) as a coactivator critically required for retinoic acid (RA)-induced transcription.	Tretinoin	205-207	C-terminal binding protein 2	Mus musculus	119-147
23775127-4	2013	CTBP2 suppression by RNA interference confers resistance to RA-induced differentiation in diverse murine and human cells.	Tretinoin	60-62	C-terminal binding protein 2	Mus musculus	0-5
23775127-5	2013	Mechanistically, we find that CTBP2 associates with RAR/RXR at RA target gene promoters and is essential for their transactivation in response to RA.	Tretinoin	52-54	C-terminal binding protein 2	Mus musculus	30-35
22049442-5	2011	As shown by heterologous expression, RIBEYE, a main component of synaptic ribbons, is responsible for PA binding at synaptic ribbons.	Phosphatidic Acids	102-104	C-terminal binding protein 2	Mus musculus	37-43
22049442-6	2011	Furthermore, RIBEYE is directly involved in the synthesis of PA.	Phosphatidic Acids	61-63	C-terminal binding protein 2	Mus musculus	13-19
22049442-7	2011	Using various independent substrate binding and enzyme assays, we demonstrate that the B domain of RIBEYE possesses lysophosphatidic acid (LPA) acyltransferase (LPAAT) activity, which leads to the generation of PA from LPA.	Phosphatidic Acids	140-142	C-terminal binding protein 2	Mus musculus	99-105
22049442-7	2011	Using various independent substrate binding and enzyme assays, we demonstrate that the B domain of RIBEYE possesses lysophosphatidic acid (LPA) acyltransferase (LPAAT) activity, which leads to the generation of PA from LPA.	lysophosphatidic acid	139-142	C-terminal binding protein 2	Mus musculus	99-105
21199918-7	2011	Interestingly, knockdown of homeodomain-interacting protein kinase 2 (HIPK2), a CtBP stability modulator, increased CtBP2 levels, suppressed expression of Mitf, REST, and melanocyte differentiation, and increased neuronal gene expression and sympathoadrenal lineage differentiation.	ctbp	80-84	C-terminal binding protein 2	Mus musculus	116-121