PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 18810759-1 2008 Granulomatous experimental autoimmune thyroiditis (G-EAT) is induced by mouse thyroglobulin (MTG)-sensitized splenocytes activated in vitro with MTG and IL-12. (Methylthio)acetic acid 93-96 thyroglobulin Mus musculus 78-91 16547286-0 2006 Iodination of tyrosyls in thyroglobulin generates neoantigenic determinants that cause thyroiditis. tyrosyls 14-22 thyroglobulin Mus musculus 26-39 16547286-1 2006 Thyroglobulin (Tg) is unique in its ability to incorporate and store available iodine in the form of iodotyrosyl residues. Iodine 79-85 thyroglobulin Mus musculus 0-13 16547286-1 2006 Thyroglobulin (Tg) is unique in its ability to incorporate and store available iodine in the form of iodotyrosyl residues. Iodine 79-85 thyroglobulin Mus musculus 15-17 16547286-1 2006 Thyroglobulin (Tg) is unique in its ability to incorporate and store available iodine in the form of iodotyrosyl residues. iodotyrosyl 101-112 thyroglobulin Mus musculus 0-13 16547286-5 2006 These results demonstrate that iodotyrosyl formation in normal Tg confers pathogenic potential to certain peptides that may otherwise remain innocuous and undetectable by conventional mapping methods. iodotyrosyl 31-42 thyroglobulin Mus musculus 63-65 16547286-1 2006 Thyroglobulin (Tg) is unique in its ability to incorporate and store available iodine in the form of iodotyrosyl residues. iodotyrosyl 101-112 thyroglobulin Mus musculus 15-17 16547286-2 2006 Iodination of Tg has been known to increase its immunopathogenicity in experimental animals, presumably through the formation of iodine-containing neoantigenic determinants that can elicit an autoimmune response, but defined pathogenic Tg peptides carrying iodotyrosyls have not yet been identified. Iodine 129-135 thyroglobulin Mus musculus 14-16 16547286-2 2006 Iodination of Tg has been known to increase its immunopathogenicity in experimental animals, presumably through the formation of iodine-containing neoantigenic determinants that can elicit an autoimmune response, but defined pathogenic Tg peptides carrying iodotyrosyls have not yet been identified. iodotyrosyls 257-269 thyroglobulin Mus musculus 14-16 15728526-2 2005 We report that a THB mAb recognizing the 5" iodine atom of the outer phenolic ring of thyroxine (T4) can block T cell recognition of the pathogenic thyroglobulin (Tg) peptide (2549-2560) that contains T4 at aa position 2553 (T4(2553)). Sapropterin 17-20 thyroglobulin Mus musculus 148-161 16306076-8 2006 Enhanced 125I- efflux upon perchlorate and presence of 125I-Tg as autoradiographic rings at follicle periphery demonstrated delayed iodide organification. Iodides 132-138 thyroglobulin Mus musculus 60-62 16084270-4 2005 A mild form of EAT was induced by subcutaneous injection of mouse thyroglobulin (MTg) with either Freund"s adjuvant (complete and incomplete, CFA and IFA) or lipopolysaccharide (LPS). (Methylthio)acetic acid 81-84 thyroglobulin Mus musculus 66-79 15878230-4 2005 As expected from the knowledge that megalin mediates Tg transcytosis, serum Tg levels were significantly reduced in homozygous (megalin-/-) mice, which, more importantly, were found to be hypothyroid, as demonstrated by significantly reduced serum free thyroxine and significantly increased serum thyroid stimulating hormone (TSH) levels. Thyroxine 253-262 thyroglobulin Mus musculus 76-78 15878230-4 2005 As expected from the knowledge that megalin mediates Tg transcytosis, serum Tg levels were significantly reduced in homozygous (megalin-/-) mice, which, more importantly, were found to be hypothyroid, as demonstrated by significantly reduced serum free thyroxine and significantly increased serum thyroid stimulating hormone (TSH) levels. Thyrotropin 326-329 thyroglobulin Mus musculus 76-78 15728526-2 2005 We report that a THB mAb recognizing the 5" iodine atom of the outer phenolic ring of thyroxine (T4) can block T cell recognition of the pathogenic thyroglobulin (Tg) peptide (2549-2560) that contains T4 at aa position 2553 (T4(2553)). Iodine 44-50 thyroglobulin Mus musculus 148-161 15728526-2 2005 We report that a THB mAb recognizing the 5" iodine atom of the outer phenolic ring of thyroxine (T4) can block T cell recognition of the pathogenic thyroglobulin (Tg) peptide (2549-2560) that contains T4 at aa position 2553 (T4(2553)). Thyroxine 86-95 thyroglobulin Mus musculus 148-161 14764582-1 2004 Secretion of thyroglobulin (Tg, a large homodimeric glycoprotein) is essential to deliver Tg to its site of iodination for thyroxine biosynthesis. Thyroxine 123-132 thyroglobulin Mus musculus 13-26 14764582-1 2004 Secretion of thyroglobulin (Tg, a large homodimeric glycoprotein) is essential to deliver Tg to its site of iodination for thyroxine biosynthesis. Thyroxine 123-132 thyroglobulin Mus musculus 28-30 14764582-1 2004 Secretion of thyroglobulin (Tg, a large homodimeric glycoprotein) is essential to deliver Tg to its site of iodination for thyroxine biosynthesis. Thyroxine 123-132 thyroglobulin Mus musculus 90-92 12023396-2 2002 One hypothesis has been that enhanced incorporation of iodine in thyroglobulin (Tg) promotes the generation of pathogenic T cell determinants. Iodine 55-61 thyroglobulin Mus musculus 65-78 10502541-12 1999 The disease, moreover, can be transferred adoptively, using spleen cells from iodine-fed donors treated in vitro with iodinated thyroglobulin. Iodine 78-84 thyroglobulin Mus musculus 128-141 11453662-6 2001 Tg, but not triiodothyronine (T(3)) significantly increased MC proliferation above control as determined by DNA content of MC cultures. Methylcholanthrene 60-62 thyroglobulin Mus musculus 0-2 11453662-6 2001 Tg, but not triiodothyronine (T(3)) significantly increased MC proliferation above control as determined by DNA content of MC cultures. Methylcholanthrene 123-125 thyroglobulin Mus musculus 0-2 11099302-1 2000 Experimental autoimmune thyroiditis (EAT) with granulomatous histopathology (G-EAT) can be induced by cells from mouse thyroglobulin (MTg)-immunized donors activated in vitro with MTg and IL-12. (Methylthio)acetic acid 134-137 thyroglobulin Mus musculus 119-132 11099302-1 2000 Experimental autoimmune thyroiditis (EAT) with granulomatous histopathology (G-EAT) can be induced by cells from mouse thyroglobulin (MTg)-immunized donors activated in vitro with MTg and IL-12. (Methylthio)acetic acid 180-183 thyroglobulin Mus musculus 119-132 11466396-1 2001 Granulomatous experimental autoimmune thyroiditis (G-EAT) is induced by transfer of mouse thyroglobulin (MTg)-sensitized spleen cells activated in vitro with MTg and anti-IL-2R or MTg and IL-12. (Methylthio)acetic acid 105-108 thyroglobulin Mus musculus 90-103 11466396-1 2001 Granulomatous experimental autoimmune thyroiditis (G-EAT) is induced by transfer of mouse thyroglobulin (MTg)-sensitized spleen cells activated in vitro with MTg and anti-IL-2R or MTg and IL-12. (Methylthio)acetic acid 158-161 thyroglobulin Mus musculus 90-103 11129114-1 2000 Experimental autoimmune thyroiditis (EAT) is a chronic inflammatory autoimmune disease that can be induced in genetically susceptible animals by immunization with mouse thyroglobulin (MTg) in an appropriate adjuvant or by the adoptive transfer of MTg-sensitized donor spleen cells, activated in vitro with MTg, into naive recipients. (Methylthio)acetic acid 184-187 thyroglobulin Mus musculus 169-182 10502541-14 1999 Based on T-cell proliferation, it appears that the NOD-H2(h4) strain of mice has innately a greater response to murine thyroglobulin than do other mouse strains and that the proliferation is increased even more by feeding iodine. Iodine 222-228 thyroglobulin Mus musculus 119-132 10502541-15 1999 We suggest, therefore, that the presence of iodine increases the autoantigenic potency of thyroglobulin, a major pathogenic antigen in the induction of autoimmune thyroiditis. Iodine 44-50 thyroglobulin Mus musculus 90-103 10358139-2 1999 Here we show that generation of the nondominant pathogenic Tg epitope (2549-2560), containing thyroxine (T4) at position 2553 (T4(2553)), is augmented by Tg-specific IgG mAbs that facilitate FcR-mediated internalization of Tg. Thyroxine 94-103 thyroglobulin Mus musculus 154-156 10447778-5 1999 We report that, in contrast to the previous findings, this antibody had an exacerbating effect on thyroiditis induced by immunization of mice with mouse thyroglobulin (MTg) and complete Freund"s adjuvant (CFA). (Methylthio)acetic acid 168-171 thyroglobulin Mus musculus 153-166 10450830-0 1999 Hexamethylene bisacetamide (HMBA) increases thyroglobulin levels in porcine thyroid cells without increasing cyclic-AMP. hexamethylene bisacetamide 0-26 thyroglobulin Mus musculus 44-57 10450830-0 1999 Hexamethylene bisacetamide (HMBA) increases thyroglobulin levels in porcine thyroid cells without increasing cyclic-AMP. hexamethylene bisacetamide 28-32 thyroglobulin Mus musculus 44-57 10358139-2 1999 Here we show that generation of the nondominant pathogenic Tg epitope (2549-2560), containing thyroxine (T4) at position 2553 (T4(2553)), is augmented by Tg-specific IgG mAbs that facilitate FcR-mediated internalization of Tg. Thyroxine 94-103 thyroglobulin Mus musculus 59-61 10358139-2 1999 Here we show that generation of the nondominant pathogenic Tg epitope (2549-2560), containing thyroxine (T4) at position 2553 (T4(2553)), is augmented by Tg-specific IgG mAbs that facilitate FcR-mediated internalization of Tg. Thyroxine 94-103 thyroglobulin Mus musculus 154-156 10028017-1 1999 The interaction of CD40 on antigen presenting cells (APC) with CD40L on mouse thyroglobulin (MTg)-specific T cells may deliver an essential signal for the development of CD4(+) experimental autoimmune thyroiditis (EAT) effector cells and anti-MTg producing B cells. (Methylthio)acetic acid 93-96 thyroglobulin Mus musculus 78-91 10650339-0 1999 Hexamethylenebisacetamide modulation of thyroglobulin and protein levels in thyroid cells is not mediated by phosphatidylinositol-3-kinase: a study with wortmannin. hexamethylene bisacetamide 0-25 thyroglobulin Mus musculus 40-53 9451592-1 1997 Mouse thyroglobulin (MTg)-sensitized spleen cells activated in vitro with MTg can induce two histologically distinct forms of experimental autoimmune thyroiditis (EAT). (Methylthio)acetic acid 21-24 thyroglobulin Mus musculus 6-19 9707574-6 1998 Comparison of the complete sequences reveals that cog/cog mice express a Leu-2263 --> Pro missense mutation in the acetylcholinesterase-homology domain of Tg. Leucine 73-76 thyroglobulin Mus musculus 158-160 9707574-8 1998 Site-directed mutagenesis of cog Tg to convert the single amino acid back to Leu-2263 restores normal Tg secretion. Leucine 77-80 thyroglobulin Mus musculus 33-35 9707574-8 1998 Site-directed mutagenesis of cog Tg to convert the single amino acid back to Leu-2263 restores normal Tg secretion. Leucine 77-80 thyroglobulin Mus musculus 102-104 9588903-2 1998 Experimental autoimmune thyroiditis (EAT) with granulomatous histopathological features can be induced by mouse thyroglobulin (MTg)-sensitized spleen cells activated in vitro with MTg and anti-interleukin-2 receptor (anti-IL-2R), anti-IL-2, or anti-interferon-gamma (anti-IFN-gamma) monoclonal antibody (MAb). (Methylthio)acetic acid 127-130 thyroglobulin Mus musculus 112-125 7511888-1 1994 There is evidence from animal models that the iodine content of thyroglobulin (Tg) may influence its antigenicity in thyroid autoimmunity. Iodine 46-52 thyroglobulin Mus musculus 64-77 7585972-1 1995 Experimental autoimmune thyroiditis (EAT) induced by the transfer of mouse thyroglobulin (MTg)-immunized spleen cells, activated in vitro with MTg, can be suppressed by oral administration of PTg to donor mice prior to immunization. (Methylthio)acetic acid 90-93 thyroglobulin Mus musculus 75-88 7585972-1 1995 Experimental autoimmune thyroiditis (EAT) induced by the transfer of mouse thyroglobulin (MTg)-immunized spleen cells, activated in vitro with MTg, can be suppressed by oral administration of PTg to donor mice prior to immunization. Teniposide 192-195 thyroglobulin Mus musculus 75-88 7558173-0 1995 Proliferation and autoantibody production by mouse thyroglobulin (MTg)-specific B cells activated in vitro by MTg and MTg-specific T cells. (Methylthio)acetic acid 66-69 thyroglobulin Mus musculus 51-64 7558173-0 1995 Proliferation and autoantibody production by mouse thyroglobulin (MTg)-specific B cells activated in vitro by MTg and MTg-specific T cells. (Methylthio)acetic acid 110-113 thyroglobulin Mus musculus 51-64 7558173-1 1995 Immunization of genetically susceptible strains of mice with mouse thyroglobulin (MTg) and adjuvant results in sensitization of MTg-specific CD4+ T cells that can induce experimental autoimmune thyroiditis (EAT) after in vitro activation with MTg. (Methylthio)acetic acid 82-85 thyroglobulin Mus musculus 67-80 7558173-1 1995 Immunization of genetically susceptible strains of mice with mouse thyroglobulin (MTg) and adjuvant results in sensitization of MTg-specific CD4+ T cells that can induce experimental autoimmune thyroiditis (EAT) after in vitro activation with MTg. (Methylthio)acetic acid 128-131 thyroglobulin Mus musculus 67-80 7558173-1 1995 Immunization of genetically susceptible strains of mice with mouse thyroglobulin (MTg) and adjuvant results in sensitization of MTg-specific CD4+ T cells that can induce experimental autoimmune thyroiditis (EAT) after in vitro activation with MTg. (Methylthio)acetic acid 128-131 thyroglobulin Mus musculus 67-80 9344702-1 1997 A few synthetic peptides corresponding to amino acid sequences on human thyroglobulin (Tg) have been reported to induce moderate thyroiditis or activate mouse Tg (MTg)-primed T cells to transfer thyroiditis in mice susceptible to experimental autoimmune thyroiditis. (Methylthio)acetic acid 163-166 thyroglobulin Mus musculus 159-161 9184913-1 1997 Experimental autoimmune thyroiditis (EAT) can be induced by transfer of mouse thyroglobulin (MTg) and lipopolysaccharide (LPS)-immunized, MTg-activated spleen cells into syngeneic recipients. (Methylthio)acetic acid 93-96 thyroglobulin Mus musculus 78-91 2564328-1 1989 Mechanisms suppressive to induction of murine experimental autoimmune thyroiditis (EAT) can be activated by pretreatment with tolerogenic doses of mouse thyroglobulin (MTg) or prior TSH infusion to raise circulatory MTg levels. (Methylthio)acetic acid 168-171 thyroglobulin Mus musculus 153-166 1672546-1 1991 Spleen cells from CBA/J mice immunized with mouse thyroglobulin (MTg) and the adjuvant lipopolysaccharide induce experimental autoimmune thyroiditis (EAT) after transfer to recipient mice if they are first activated in vitro with MTg. (Methylthio)acetic acid 65-68 thyroglobulin Mus musculus 50-63 1672546-1 1991 Spleen cells from CBA/J mice immunized with mouse thyroglobulin (MTg) and the adjuvant lipopolysaccharide induce experimental autoimmune thyroiditis (EAT) after transfer to recipient mice if they are first activated in vitro with MTg. (Methylthio)acetic acid 230-233 thyroglobulin Mus musculus 50-63 34552555-13 2021 Our results strongly suggest that primary cilia harbors LRP2/megalin, and are involved in TSH-mediated endocytosis of Tg in murine thyroid follicles. Thyrotropin 90-93 thyroglobulin Mus musculus 118-120 1517579-1 1992 Experimental autoimmune thyroiditis (EAT) can be induced in mice after the transfer of mouse thyroglobulin (MTg)-sensitized donor spleen cells that have been activated in vitro with MTg. (Methylthio)acetic acid 108-111 thyroglobulin Mus musculus 93-106 1643752-1 1992 We have used the mouse model of experimental autoimmune thyroiditis (EAT) to examine the hypothesis that the strengthening of self-tolerance to thyroglobulin by exogenous mouse thyroglobulin (MTg) or stimulation of endogenous MTg secretion by thyroid-stimulating hormone (TSH) is correlated with the length of time MTg rises above the normal range. Thyrotropin 243-270 thyroglobulin Mus musculus 144-157 1643752-1 1992 We have used the mouse model of experimental autoimmune thyroiditis (EAT) to examine the hypothesis that the strengthening of self-tolerance to thyroglobulin by exogenous mouse thyroglobulin (MTg) or stimulation of endogenous MTg secretion by thyroid-stimulating hormone (TSH) is correlated with the length of time MTg rises above the normal range. Thyrotropin 272-275 thyroglobulin Mus musculus 144-157 2924725-6 1989 Sucrose density gradient velocity centrifugation followed by RIA was used to determine the sedimentation properties of cog/cog TG. Sucrose 0-7 thyroglobulin Mus musculus 127-129 2924725-13 1989 However, by polyacrylamide gradient gel electrophoresis, distinct 125I-labeled bands comigrating with normal TG were present. Iodine-125 66-70 thyroglobulin Mus musculus 109-111 3488488-4 1986 It appears that only these T lymphoblasts sensitized on thyroid monolayers are specifically labelled by fluorescein-conjugated thyroglobulin. Fluorescein 104-115 thyroglobulin Mus musculus 127-140 2924725-16 1989 With [35S]methionine labeling, cog/cog and +/cog thyroids formed TG with the same electrophoretic mobilities. Sulfur-35 6-9 thyroglobulin Mus musculus 65-67 2924725-16 1989 With [35S]methionine labeling, cog/cog and +/cog thyroids formed TG with the same electrophoretic mobilities. Methionine 10-20 thyroglobulin Mus musculus 65-67 2902931-1 1988 Experimental autoimmune thyroiditis (EAT) can be induced in CBA/J mice following the transfer of spleen cells from mouse thyroglobulin (MTg)-sensitized donors that have been activated in vitro with MTg. (Methylthio)acetic acid 136-139 thyroglobulin Mus musculus 121-134 3197917-1 1988 Mouse 330 kDa thyroglobulin labeled in vivo was analyzed using a tryptic peptide mapping technique and high performance liquid chromatography (HPLC). Peptides 73-80 thyroglobulin Mus musculus 14-27 3197917-5 1988 These data indicate that there is some preferential iodination site(s) within the thyroglobulin molecule and also that their iodoamino acid composition is predetermined. iodoamino acid 125-139 thyroglobulin Mus musculus 82-95 3416995-0 1988 Release of 3,5,3"-triiodothyronine, thyroxine and thyroglobulin from TSH-stimulated mouse thyroids in the perifusion system. Thyrotropin 69-72 thyroglobulin Mus musculus 50-63 3802208-1 1986 Experimental autoimmune thyroiditis (EAT) can be induced in susceptible strains of mice by injection of mouse thyroglobulin (MTg) and adjuvant. (Methylthio)acetic acid 125-128 thyroglobulin Mus musculus 110-123 3516644-4 1986 The main factors known to affect diffusion of Tgb in the colloid space are concentration and actual physico-chemical properties of the Tgb molecule itself, the latter parameter depending on several factors such as sugar content, iodination degree, etc. Sugars 214-219 thyroglobulin Mus musculus 46-49 3516644-5 1986 Additional factors are thyrotropin which speeds up and drugs such as pentobarbital or verapamil which slow down the velocity of Tgb diffusion. Pentobarbital 69-82 thyroglobulin Mus musculus 128-131 3516644-5 1986 Additional factors are thyrotropin which speeds up and drugs such as pentobarbital or verapamil which slow down the velocity of Tgb diffusion. Verapamil 86-95 thyroglobulin Mus musculus 128-131 3516644-6 1986 High iodine supply has a retarding effect on Tgb diffusion in the colloid of mice thyroids. Iodine 5-11 thyroglobulin Mus musculus 45-48 6205252-0 1984 Monoclonal antibodies to hog thyroglobulin recognizing disulfide-dependent conformational structures. Disulfides 55-64 thyroglobulin Mus musculus 29-42 3873286-1 1985 Spleen cells from CBA/J or SJL mice sensitized with mouse thyroglobulin (MTg) and lipopolysaccharide (LPS) could be activated in vitro with MTg to transfer experimental autoimmune thyroiditis (EAT) to normal syngeneic recipients. (Methylthio)acetic acid 73-76 thyroglobulin Mus musculus 58-71 3873286-1 1985 Spleen cells from CBA/J or SJL mice sensitized with mouse thyroglobulin (MTg) and lipopolysaccharide (LPS) could be activated in vitro with MTg to transfer experimental autoimmune thyroiditis (EAT) to normal syngeneic recipients. (Methylthio)acetic acid 140-143 thyroglobulin Mus musculus 58-71 7430900-5 1980 Thyrotrophin (TSH) increased the rate of thyroglobulin hydrolysis and hormone release from both pools by up to four to six times the basal rate, the effect being maximal 2 h after administration of TSH and lasting for 6-8 h. The rate of thyroglobulin hydrolysis after TSH was similar in both pools but the rate of release of labelled iodothyronines was significantly higher from from the old pool. Thyrotropin 14-17 thyroglobulin Mus musculus 41-54 7430900-5 1980 Thyrotrophin (TSH) increased the rate of thyroglobulin hydrolysis and hormone release from both pools by up to four to six times the basal rate, the effect being maximal 2 h after administration of TSH and lasting for 6-8 h. The rate of thyroglobulin hydrolysis after TSH was similar in both pools but the rate of release of labelled iodothyronines was significantly higher from from the old pool. iodothyronines 334-348 thyroglobulin Mus musculus 41-54 6424911-2 1984 These images give new information related to iodine and sulfur load of thyroglobulin and to the intensity of iodine concentration in lysosomes of thyroid cells. Sulfur 56-62 thyroglobulin Mus musculus 71-84 7021024-2 1981 Autoantibody to thyroglobulin (Tg) induced by immunization with cross-reactive xenogeneic Tg in Freund"s complete adjuvant and autoerythrocyte antibody induced by the injection of xenogeneic erythrocytes were studied in C57Bl/6 and BALB/c male mice. freund"s 96-104 thyroglobulin Mus musculus 16-29 7430900-5 1980 Thyrotrophin (TSH) increased the rate of thyroglobulin hydrolysis and hormone release from both pools by up to four to six times the basal rate, the effect being maximal 2 h after administration of TSH and lasting for 6-8 h. The rate of thyroglobulin hydrolysis after TSH was similar in both pools but the rate of release of labelled iodothyronines was significantly higher from from the old pool. Thyrotropin 14-17 thyroglobulin Mus musculus 237-250 323406-1 1977 The administration of soluble mouse thyroglobulin (MTg) in conjunction with bacterial lipopolysaccharide (LPS) led to the termination of natural tolerance to MTg in mice. (Methylthio)acetic acid 51-54 thyroglobulin Mus musculus 36-49 730552-6 1978 This phenomenon indicates that the Golgi apparatus has a functional polarity for the addition of carbohydrates to thyroglobulin and other proteins. Carbohydrates 97-110 thyroglobulin Mus musculus 114-127 24395757-1 2014 We have created a mouse model expressing tamoxifen-inducible Cre recombinase (CreER(T2) ) under the control of the thyroglobulin (Tg) gene promoter to be able to study the role of defined genetic modifications in the regulation of thyroid function. Tamoxifen 41-50 thyroglobulin Mus musculus 115-128 26158397-4 2015 Guided by the hypothalamus-pituitary-thyroid axis as a fixed set-point regulator in thyroid hormone metabolism, we used a murine model and compared at key junctures the capacity of circulating thyroglobulin level (raised by thyroid-stimulating hormone or exogenous thyroglobulin administration) to strengthen self-tolerance and resist autoimmune thyroiditis. Thyrotropin 224-251 thyroglobulin Mus musculus 193-206 25101840-7 2014 Low-dose treatment of TBTCl exposure markedly decreased the serum thyroid hormone levels via the down-regulation of the thyroid peroxidase (TPO) and thyroglobulin (Tg) genes by 40% and 25%, respectively, while augmenting the thyroid stimulating hormone (TSH) levels. tributyltin 22-27 thyroglobulin Mus musculus 149-162 24879795-0 2014 The thyroxine-containing thyroglobulin peptide (aa 2549-2560) is a target epitope in iodide-accelerated spontaneous autoimmune thyroiditis. Iodides 85-91 thyroglobulin Mus musculus 25-38 24879795-3 2014 In this study, we show that the previously identified thyroglobulin (Tg) T cell epitope p2549-2560 containing thyroxine at position 2553 (T4p2553) induces thyroiditis as well as strong specific T and B cell responses in NOD.H2(h4) mice. Thyroxine 110-119 thyroglobulin Mus musculus 54-67 32961913-1 2020 BACKGROUND: Thyroid follicular cells have physiologically high levels of reactive oxygen species because oxidation of iodide is essential for the iodination of thyroglobulin (Tg) during thyroid hormone synthesis. Oxygen 82-88 thyroglobulin Mus musculus 160-173 32961913-1 2020 BACKGROUND: Thyroid follicular cells have physiologically high levels of reactive oxygen species because oxidation of iodide is essential for the iodination of thyroglobulin (Tg) during thyroid hormone synthesis. Iodides 118-124 thyroglobulin Mus musculus 160-173 20687399-0 2010 Iodine content of thyroglobulin in Nod.H2h4 mice developing iodine-accelerated autoimmune thyroiditis. Iodine 0-6 thyroglobulin Mus musculus 18-31 24098053-1 2013 NOD.H-2h4 mice given NaI in their drinking water develop iodine-accelerated spontaneous autoimmune thyroiditis (ISAT) with chronic inflammation of the thyroid by T and B cells and production of anti-mouse thyroglobulin (MTg) autoantibody. Sodium Iodide 21-24 thyroglobulin Mus musculus 205-218 20943721-7 2011 Furthermore, the extent and duration of radioiodine accumulation stimulated by bTSH was less in the thyroids of the thyroid-targeted RET/PTC1 (thyroglobulin (Tg)-PTC1) mice bearing thyroid tumors compared with the thyroids in wild-type (WT) mice. Iodine-131 40-51 thyroglobulin Mus musculus 143-156 23360087-2 2013 The thyroid transcription factors-NKx2 homeobox 1 (NKx2-1, formerly called TTF-1) and Paired box gene 8 (Pax8)-are known to associate biochemically and synergistically in the activation of thyroid functional genes including the sodium/iodide symporter (NIS), thyrotropin (TSH) receptor (TSHR), thyroglobulin (Tg), and thyroid peroxidase (TPO) genes. Sodium 228-234 thyroglobulin Mus musculus 294-307 23360087-2 2013 The thyroid transcription factors-NKx2 homeobox 1 (NKx2-1, formerly called TTF-1) and Paired box gene 8 (Pax8)-are known to associate biochemically and synergistically in the activation of thyroid functional genes including the sodium/iodide symporter (NIS), thyrotropin (TSH) receptor (TSHR), thyroglobulin (Tg), and thyroid peroxidase (TPO) genes. Sodium 228-234 thyroglobulin Mus musculus 309-311 23360087-2 2013 The thyroid transcription factors-NKx2 homeobox 1 (NKx2-1, formerly called TTF-1) and Paired box gene 8 (Pax8)-are known to associate biochemically and synergistically in the activation of thyroid functional genes including the sodium/iodide symporter (NIS), thyrotropin (TSH) receptor (TSHR), thyroglobulin (Tg), and thyroid peroxidase (TPO) genes. Iodides 235-241 thyroglobulin Mus musculus 294-307 23360087-2 2013 The thyroid transcription factors-NKx2 homeobox 1 (NKx2-1, formerly called TTF-1) and Paired box gene 8 (Pax8)-are known to associate biochemically and synergistically in the activation of thyroid functional genes including the sodium/iodide symporter (NIS), thyrotropin (TSH) receptor (TSHR), thyroglobulin (Tg), and thyroid peroxidase (TPO) genes. Iodides 235-241 thyroglobulin Mus musculus 309-311 23360087-2 2013 The thyroid transcription factors-NKx2 homeobox 1 (NKx2-1, formerly called TTF-1) and Paired box gene 8 (Pax8)-are known to associate biochemically and synergistically in the activation of thyroid functional genes including the sodium/iodide symporter (NIS), thyrotropin (TSH) receptor (TSHR), thyroglobulin (Tg), and thyroid peroxidase (TPO) genes. Nickel 253-256 thyroglobulin Mus musculus 294-307 23360087-2 2013 The thyroid transcription factors-NKx2 homeobox 1 (NKx2-1, formerly called TTF-1) and Paired box gene 8 (Pax8)-are known to associate biochemically and synergistically in the activation of thyroid functional genes including the sodium/iodide symporter (NIS), thyrotropin (TSH) receptor (TSHR), thyroglobulin (Tg), and thyroid peroxidase (TPO) genes. Nickel 253-256 thyroglobulin Mus musculus 309-311 20687399-0 2010 Iodine content of thyroglobulin in Nod.H2h4 mice developing iodine-accelerated autoimmune thyroiditis. h2h4 39-43 thyroglobulin Mus musculus 18-31 20687399-0 2010 Iodine content of thyroglobulin in Nod.H2h4 mice developing iodine-accelerated autoimmune thyroiditis. Iodine 60-66 thyroglobulin Mus musculus 18-31 20687399-2 2010 The aim of the study was to examine whether the NOD.H2h4 genetic background predisposes to enhanced iodine organification in thyroglobulin (Tg), a target autoantigen in ISAT. h2h4 52-56 thyroglobulin Mus musculus 125-138 20687399-2 2010 The aim of the study was to examine whether the NOD.H2h4 genetic background predisposes to enhanced iodine organification in thyroglobulin (Tg), a target autoantigen in ISAT. h2h4 52-56 thyroglobulin Mus musculus 140-142 20687399-2 2010 The aim of the study was to examine whether the NOD.H2h4 genetic background predisposes to enhanced iodine organification in thyroglobulin (Tg), a target autoantigen in ISAT. Iodine 100-106 thyroglobulin Mus musculus 125-138 20687399-2 2010 The aim of the study was to examine whether the NOD.H2h4 genetic background predisposes to enhanced iodine organification in thyroglobulin (Tg), a target autoantigen in ISAT. Iodine 100-106 thyroglobulin Mus musculus 140-142 20687399-4 2010 Additionally, we tested whether humoral or cellular immune responses of iodine-fed NOD.H2h4 mice are preferentially directed to Tg with increased iodine content (I-Tg) or known pathogenic Tg peptides that contained iodine. Iodine 72-78 thyroglobulin Mus musculus 128-130 20687399-4 2010 Additionally, we tested whether humoral or cellular immune responses of iodine-fed NOD.H2h4 mice are preferentially directed to Tg with increased iodine content (I-Tg) or known pathogenic Tg peptides that contained iodine. Iodine 72-78 thyroglobulin Mus musculus 164-166 20687399-4 2010 Additionally, we tested whether humoral or cellular immune responses of iodine-fed NOD.H2h4 mice are preferentially directed to Tg with increased iodine content (I-Tg) or known pathogenic Tg peptides that contained iodine. Iodine 72-78 thyroglobulin Mus musculus 164-166 20687399-4 2010 Additionally, we tested whether humoral or cellular immune responses of iodine-fed NOD.H2h4 mice are preferentially directed to Tg with increased iodine content (I-Tg) or known pathogenic Tg peptides that contained iodine. h2h4 87-91 thyroglobulin Mus musculus 128-130 20687399-4 2010 Additionally, we tested whether humoral or cellular immune responses of iodine-fed NOD.H2h4 mice are preferentially directed to Tg with increased iodine content (I-Tg) or known pathogenic Tg peptides that contained iodine. h2h4 87-91 thyroglobulin Mus musculus 164-166 20687399-4 2010 Additionally, we tested whether humoral or cellular immune responses of iodine-fed NOD.H2h4 mice are preferentially directed to Tg with increased iodine content (I-Tg) or known pathogenic Tg peptides that contained iodine. h2h4 87-91 thyroglobulin Mus musculus 164-166 20687399-5 2010 RESULTS: The iodine content of Tg was not significantly different between control (9.0 +/- 2.7 I atoms per monomer) and iodine-fed mice (10.9 +/- 0.3 I atoms per monomer). Iodine 13-19 thyroglobulin Mus musculus 31-33 20687399-6 2010 Furthermore, in iodine-fed NOD.H2h4 mice developing ISAT, strong but equivalent serum IgG responses were detected to both Tg or I-Tg, whereas their lymphoid cells were stimulated weakly but equally well by Tg or I-Tg in vitro and did not show reactivity against a panel of five pathogenic Tg peptides that contained iodine. Iodine 16-22 thyroglobulin Mus musculus 122-124 20687399-6 2010 Furthermore, in iodine-fed NOD.H2h4 mice developing ISAT, strong but equivalent serum IgG responses were detected to both Tg or I-Tg, whereas their lymphoid cells were stimulated weakly but equally well by Tg or I-Tg in vitro and did not show reactivity against a panel of five pathogenic Tg peptides that contained iodine. Iodine 16-22 thyroglobulin Mus musculus 130-132 20687399-6 2010 Furthermore, in iodine-fed NOD.H2h4 mice developing ISAT, strong but equivalent serum IgG responses were detected to both Tg or I-Tg, whereas their lymphoid cells were stimulated weakly but equally well by Tg or I-Tg in vitro and did not show reactivity against a panel of five pathogenic Tg peptides that contained iodine. Iodine 16-22 thyroglobulin Mus musculus 130-132 20687399-6 2010 Furthermore, in iodine-fed NOD.H2h4 mice developing ISAT, strong but equivalent serum IgG responses were detected to both Tg or I-Tg, whereas their lymphoid cells were stimulated weakly but equally well by Tg or I-Tg in vitro and did not show reactivity against a panel of five pathogenic Tg peptides that contained iodine. Iodine 16-22 thyroglobulin Mus musculus 130-132 20687399-6 2010 Furthermore, in iodine-fed NOD.H2h4 mice developing ISAT, strong but equivalent serum IgG responses were detected to both Tg or I-Tg, whereas their lymphoid cells were stimulated weakly but equally well by Tg or I-Tg in vitro and did not show reactivity against a panel of five pathogenic Tg peptides that contained iodine. Iodine 16-22 thyroglobulin Mus musculus 130-132 20687399-6 2010 Furthermore, in iodine-fed NOD.H2h4 mice developing ISAT, strong but equivalent serum IgG responses were detected to both Tg or I-Tg, whereas their lymphoid cells were stimulated weakly but equally well by Tg or I-Tg in vitro and did not show reactivity against a panel of five pathogenic Tg peptides that contained iodine. Iodine 52-53 thyroglobulin Mus musculus 122-124 19845793-1 2010 Granulomatous experimental autoimmune thyroiditis (G-EAT) is induced by mouse thyroglobulin (MTg)-sensitized splenocytes activated with MTg and interleukin (IL)-12. (Methylthio)acetic acid 93-96 thyroglobulin Mus musculus 78-91