PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
22669534-10	2012	In addition, UA inhibited Bcap-37 tumor cell proliferation.	usnic acid	13-15	prohibitin 2	Mus musculus	26-33
22759596-1	2012	Benzo[a]pyrene (BaP) is a widespread environmental carcinogen activated by cytochrome P450 (P450) enzymes.	Benzo(a)pyrene	0-14	prohibitin 2	Mus musculus	16-19
22264856-2	2012	We sought to evaluate the relationship between 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) and P-gp expression using breast carcinoma Bcap37/multidrug resistant (MDR1) and Bcap37 in vitro and in vivo.	Fluorodeoxyglucose F18	47-78	prohibitin 2	Mus musculus	171-177
22430258-6	2012	The microsomes from BaP-preexposed mice generated greater proportion of BaP 7,8-diol and BaP 3,6- and 6,12-diones compared to other experimental groups.	7,8-diol	76-84	prohibitin 2	Mus musculus	20-23
22430258-6	2012	The microsomes from BaP-preexposed mice generated greater proportion of BaP 7,8-diol and BaP 3,6- and 6,12-diones compared to other experimental groups.	7,8-diol	76-84	prohibitin 2	Mus musculus	72-75
22430258-6	2012	The microsomes from BaP-preexposed mice generated greater proportion of BaP 7,8-diol and BaP 3,6- and 6,12-diones compared to other experimental groups.	7,8-diol	76-84	prohibitin 2	Mus musculus	72-75
22430258-7	2012	Additionally, microsomes from BaP-pretreated mice produced greater proportion of FLA 2, 3-diol and 2, 3 D FLA when microsomes were incubated with FLA alone or a combination of BaP and FLA.	fla 2, 3-diol	81-94	prohibitin 2	Mus musculus	30-33
22430258-7	2012	Additionally, microsomes from BaP-pretreated mice produced greater proportion of FLA 2, 3-diol and 2, 3 D FLA when microsomes were incubated with FLA alone or a combination of BaP and FLA.	fluoranthene	81-84	prohibitin 2	Mus musculus	30-33
22430258-7	2012	Additionally, microsomes from BaP-pretreated mice produced greater proportion of FLA 2, 3-diol and 2, 3 D FLA when microsomes were incubated with FLA alone or a combination of BaP and FLA.	fluoranthene	106-109	prohibitin 2	Mus musculus	30-33
22430258-9	2012	The biotransformation of BaP and FLA as a consequence of prior and simultaneous exposure to BaP may influence the growth of tumors.	fluoranthene	33-36	prohibitin 2	Mus musculus	92-95
22264856-3	2012	METHODS: The function of P-gp expressed in Bcap37/MDR1 cells was evaluated using verapamil (VER), a classical inhibitor of P-gp.	Verapamil	81-90	prohibitin 2	Mus musculus	43-49
20188852-1	2011	Benzo(a)pyrene (BaP) is a mutagenic and carcinogenic environmental contaminant.	Benzo(a)pyrene	0-14	prohibitin 2	Mus musculus	16-19
22613061-1	2012	We have used mouse hepatoma cells in culture to study acute, short-term high-dose effects of hexavalent chromium on gene regulation directed by the polycyclic aromatic hydrocarbon benzo[a]pyrene (BaP).	polycyclic aromatic hydrocarbon benzo[a]pyrene	148-194	prohibitin 2	Mus musculus	196-199
22479600-5	2012	Knockdown of PHB1 or PHB2 by oligonucleotide siRNA significantly reduced the expression of adipogenic markers, the accumulation of lipids and the phosphorylation of extracellular signal-regulated kinases.	Oligonucleotides	29-44	prohibitin 2	Mus musculus	21-25
22876182-7	2012	The interaction of Bap with Gp96 provokes a significant reduction in the capacity of S. aureus to invade epithelial cells by interfering with the fibronectin binding protein invasion pathway.	gp96	28-32	prohibitin 2	Mus musculus	19-22
22027502-1	2012	In the present study, the antioxidative and anticlastogenic effects of curcumin and piperine separately and in combination have been investigated against benzo(a)pyrene (BaP)-mediated toxicity in mice.	Curcumin	71-79	prohibitin 2	Mus musculus	170-173
22027502-4	2012	Pretreatments with curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of LPO, PCC, and incidence of MNPCEs but elevated the level of GSH and enzyme activities of GPx, GR, SOD, CAT, and glutathione-S-transferase (GST) when compared to the BaP-treated group.	Curcumin	19-27	prohibitin 2	Mus musculus	95-98
22027502-4	2012	Pretreatments with curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of LPO, PCC, and incidence of MNPCEs but elevated the level of GSH and enzyme activities of GPx, GR, SOD, CAT, and glutathione-S-transferase (GST) when compared to the BaP-treated group.	Curcumin	19-27	prohibitin 2	Mus musculus	302-305
22027502-4	2012	Pretreatments with curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of LPO, PCC, and incidence of MNPCEs but elevated the level of GSH and enzyme activities of GPx, GR, SOD, CAT, and glutathione-S-transferase (GST) when compared to the BaP-treated group.	Curcumin	32-40	prohibitin 2	Mus musculus	95-98
22027502-4	2012	Pretreatments with curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of LPO, PCC, and incidence of MNPCEs but elevated the level of GSH and enzyme activities of GPx, GR, SOD, CAT, and glutathione-S-transferase (GST) when compared to the BaP-treated group.	Curcumin	32-40	prohibitin 2	Mus musculus	302-305
22027502-4	2012	Pretreatments with curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of LPO, PCC, and incidence of MNPCEs but elevated the level of GSH and enzyme activities of GPx, GR, SOD, CAT, and glutathione-S-transferase (GST) when compared to the BaP-treated group.	piperine	46-54	prohibitin 2	Mus musculus	95-98
22027502-4	2012	Pretreatments with curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of LPO, PCC, and incidence of MNPCEs but elevated the level of GSH and enzyme activities of GPx, GR, SOD, CAT, and glutathione-S-transferase (GST) when compared to the BaP-treated group.	piperine	46-54	prohibitin 2	Mus musculus	302-305
22027502-4	2012	Pretreatments with curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of LPO, PCC, and incidence of MNPCEs but elevated the level of GSH and enzyme activities of GPx, GR, SOD, CAT, and glutathione-S-transferase (GST) when compared to the BaP-treated group.	Glutathione	197-200	prohibitin 2	Mus musculus	95-98
22027502-5	2012	The effect of curcumin plus piperine is more pronounced as compared to curcumin in attenuating BaP-induced oxidative insult and clastogenicity.	Curcumin	14-22	prohibitin 2	Mus musculus	95-98
22027502-5	2012	The effect of curcumin plus piperine is more pronounced as compared to curcumin in attenuating BaP-induced oxidative insult and clastogenicity.	piperine	28-36	prohibitin 2	Mus musculus	95-98
22027502-5	2012	The effect of curcumin plus piperine is more pronounced as compared to curcumin in attenuating BaP-induced oxidative insult and clastogenicity.	Curcumin	71-79	prohibitin 2	Mus musculus	95-98
21827816-1	2011	The present study was planned to investigate the antigenotoxic effects of curcumin and piperine separately and in combination against benzo(a)pyrene (BaP) induced DNA damage in lungs and livers of mice.	Curcumin	74-82	prohibitin 2	Mus musculus	150-153
21827816-1	2011	The present study was planned to investigate the antigenotoxic effects of curcumin and piperine separately and in combination against benzo(a)pyrene (BaP) induced DNA damage in lungs and livers of mice.	piperine	87-95	prohibitin 2	Mus musculus	150-153
21827816-1	2011	The present study was planned to investigate the antigenotoxic effects of curcumin and piperine separately and in combination against benzo(a)pyrene (BaP) induced DNA damage in lungs and livers of mice.	Benzo(a)pyrene	134-148	prohibitin 2	Mus musculus	150-153
21827816-3	2011	A single dose of BaP to normal mice increased the level of 8-oxo-2"-deoxyguanosine (8-oxo-dG) content and % DNA in the comet tail in the lungs and liver.	8-ohdg	59-82	prohibitin 2	Mus musculus	17-20
21827816-3	2011	A single dose of BaP to normal mice increased the level of 8-oxo-2"-deoxyguanosine (8-oxo-dG) content and % DNA in the comet tail in the lungs and liver.	8-ohdg	84-92	prohibitin 2	Mus musculus	17-20
21827816-4	2011	Pretreatments of curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of 8-oxo-dG content and % DNA in the comet tail in both the tissues.	Curcumin	17-25	prohibitin 2	Mus musculus	93-96
21827816-4	2011	Pretreatments of curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of 8-oxo-dG content and % DNA in the comet tail in both the tissues.	Curcumin	30-38	prohibitin 2	Mus musculus	93-96
21827816-4	2011	Pretreatments of curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of 8-oxo-dG content and % DNA in the comet tail in both the tissues.	piperine	44-52	prohibitin 2	Mus musculus	93-96
21827816-4	2011	Pretreatments of curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of 8-oxo-dG content and % DNA in the comet tail in both the tissues.	8-ohdg	135-143	prohibitin 2	Mus musculus	93-96
21827816-5	2011	Moreover, the genoprotective potential of curcumin plus piperine was significantly higher as compared to curcumin alone against BaP induced DNA damage.	Curcumin	42-50	prohibitin 2	Mus musculus	128-131
21827816-5	2011	Moreover, the genoprotective potential of curcumin plus piperine was significantly higher as compared to curcumin alone against BaP induced DNA damage.	piperine	56-64	prohibitin 2	Mus musculus	128-131
21827816-5	2011	Moreover, the genoprotective potential of curcumin plus piperine was significantly higher as compared to curcumin alone against BaP induced DNA damage.	Curcumin	105-113	prohibitin 2	Mus musculus	128-131
21689744-4	2011	Here we show that Calcium/Calmodulin-dependent kinase IV (CaMK IV) specifically binds to the C terminus of PHB2 and phosphorylates PHB2 at serine 91.	Serine	139-145	prohibitin 2	Mus musculus	107-111
21689744-4	2011	Here we show that Calcium/Calmodulin-dependent kinase IV (CaMK IV) specifically binds to the C terminus of PHB2 and phosphorylates PHB2 at serine 91.	Serine	139-145	prohibitin 2	Mus musculus	131-135
20422711-1	2010	Benzo(a)pyrene (BaP), a cigarette smoke component, is metabolized to diol esters (BPDE) that bind to DNA and form mutagenic BPDE-DNA adducts.	Benzo(a)pyrene	0-14	prohibitin 2	Mus musculus	16-19
20422711-1	2010	Benzo(a)pyrene (BaP), a cigarette smoke component, is metabolized to diol esters (BPDE) that bind to DNA and form mutagenic BPDE-DNA adducts.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	124-128	prohibitin 2	Mus musculus	16-19
20959514-0	2011	Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration.	sphingosine 1-phosphate	0-23	prohibitin 2	Mus musculus	88-100
20422711-1	2010	Benzo(a)pyrene (BaP), a cigarette smoke component, is metabolized to diol esters (BPDE) that bind to DNA and form mutagenic BPDE-DNA adducts.	diol esters	69-80	prohibitin 2	Mus musculus	16-19
20422711-1	2010	Benzo(a)pyrene (BaP), a cigarette smoke component, is metabolized to diol esters (BPDE) that bind to DNA and form mutagenic BPDE-DNA adducts.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	82-86	prohibitin 2	Mus musculus	16-19
19228760-3	2009	Therefore, we tested the hypothesis that mainstream cigarette smoke and a cigarette smoke constituent, benzo[a]pyrene (BaP), induce apoptosis in ovarian follicles.	Benzo(a)pyrene	103-117	prohibitin 2	Mus musculus	119-122
21137059-1	2010	PURPOSE: Previously, we reported that glycine N-methyltransferase (GNMT) interacts with benzo[a]pyrene (BaP) and inhibits BaP-DNA adducts formation.	Benzo(a)pyrene	88-102	prohibitin 2	Mus musculus	104-107
19409565-1	2009	The carcinogenic polycylic aromatic hydrocarbon, benzo(a)pyrene (BaP), has been shown to generate reactive oxygen species (ROS) and accelerate the development of atherosclerosis.	polycylic aromatic hydrocarbon	17-47	prohibitin 2	Mus musculus	65-68
19409565-1	2009	The carcinogenic polycylic aromatic hydrocarbon, benzo(a)pyrene (BaP), has been shown to generate reactive oxygen species (ROS) and accelerate the development of atherosclerosis.	Benzo(a)pyrene	49-63	prohibitin 2	Mus musculus	65-68
19409565-1	2009	The carcinogenic polycylic aromatic hydrocarbon, benzo(a)pyrene (BaP), has been shown to generate reactive oxygen species (ROS) and accelerate the development of atherosclerosis.	Reactive Oxygen Species	98-121	prohibitin 2	Mus musculus	65-68
19409565-1	2009	The carcinogenic polycylic aromatic hydrocarbon, benzo(a)pyrene (BaP), has been shown to generate reactive oxygen species (ROS) and accelerate the development of atherosclerosis.	Reactive Oxygen Species	123-126	prohibitin 2	Mus musculus	65-68
19409565-2	2009	To assess the causal role of BaP-generated ROS in this process, we evaluated atherosclerotic metrics in apolipoprotein E-deficient (ApoE(-/-)) mice with or without overexpression of Cu/Zn-superoxide dismutase (Cu/Zn-SOD) and/or catalase.	Reactive Oxygen Species	43-46	prohibitin 2	Mus musculus	29-32
19409565-8	2009	These observations, together with the functions of catalase and Cu/Zn-SOD to scavenge hydrogen peroxide and superoxide anions, implicate a causal role of ROS in the pathogenesis of BaP-induced atherosclerosis.	Hydrogen Peroxide	86-103	prohibitin 2	Mus musculus	181-184
19409565-8	2009	These observations, together with the functions of catalase and Cu/Zn-SOD to scavenge hydrogen peroxide and superoxide anions, implicate a causal role of ROS in the pathogenesis of BaP-induced atherosclerosis.	Superoxides	108-125	prohibitin 2	Mus musculus	181-184
19409565-8	2009	These observations, together with the functions of catalase and Cu/Zn-SOD to scavenge hydrogen peroxide and superoxide anions, implicate a causal role of ROS in the pathogenesis of BaP-induced atherosclerosis.	Reactive Oxygen Species	154-157	prohibitin 2	Mus musculus	181-184
16949149-5	2006	In vitro, PGA-CDDP was less potent than free CDDP at inhibiting cell growth in the Bcap-37 cell line.	pga-cddp	10-18	prohibitin 2	Mus musculus	83-90
21218107-10	2008	Taken together, these results demonstrate that by inducing CYP1A1/2, ellipticine and BaP modulate their own enzymatic metabolic activation and detoxication, thereby modulating their either pharmacological (ellipticine) and/or genotoxic potential (both compounds).	ellipticine	206-217	prohibitin 2	Mus musculus	85-88
17997381-1	2008	The CYP1A1, CYP1A2, and CYP1B1 enzymes are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); metabolism of BaP by these enzymes leads to electrophilic intermediates and genotoxicity.	Benzo(a)pyrene	56-70	prohibitin 2	Mus musculus	72-75
17997381-1	2008	The CYP1A1, CYP1A2, and CYP1B1 enzymes are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); metabolism of BaP by these enzymes leads to electrophilic intermediates and genotoxicity.	Benzo(a)pyrene	56-70	prohibitin 2	Mus musculus	139-142
17997381-1	2008	The CYP1A1, CYP1A2, and CYP1B1 enzymes are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); metabolism of BaP by these enzymes leads to electrophilic intermediates and genotoxicity.	Polychlorinated Dibenzodioxins	81-116	prohibitin 2	Mus musculus	139-142
17997381-1	2008	The CYP1A1, CYP1A2, and CYP1B1 enzymes are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); metabolism of BaP by these enzymes leads to electrophilic intermediates and genotoxicity.	Polychlorinated Dibenzodioxins	118-122	prohibitin 2	Mus musculus	72-75
17997381-1	2008	The CYP1A1, CYP1A2, and CYP1B1 enzymes are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); metabolism of BaP by these enzymes leads to electrophilic intermediates and genotoxicity.	Polychlorinated Dibenzodioxins	118-122	prohibitin 2	Mus musculus	139-142
19105532-1	2008	We evaluated the mechanisms using immunohistochemistry whereby chrysotile asbestos and benzo(a)pyrene (BaP) instilled intratracheally into lung-specific dominant-negative p53 (dnp53) mice might interact in causing lung carcinomas and fibrosis.	Benzo(a)pyrene	87-101	prohibitin 2	Mus musculus	103-106
18396263-2	2008	We previously demonstrated that exposure to benzo[a]pyrene (BaP), an environmental pollutant present in high concentrations in urban smog and cigarette smoke, inhibits osteoclast differentiation and bone resorption.	Benzo(a)pyrene	44-58	prohibitin 2	Mus musculus	60-63
17909032-3	2007	Glutathione transferase pi (GSTP) catalyzes the detoxification of electrophilic diol epoxides produced by the metabolism of polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP), a common constituent of tobacco smoke.	diol epoxides	80-93	prohibitin 2	Mus musculus	181-184
17909032-3	2007	Glutathione transferase pi (GSTP) catalyzes the detoxification of electrophilic diol epoxides produced by the metabolism of polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP), a common constituent of tobacco smoke.	Polycyclic Aromatic Hydrocarbons	124-156	prohibitin 2	Mus musculus	181-184
17909032-3	2007	Glutathione transferase pi (GSTP) catalyzes the detoxification of electrophilic diol epoxides produced by the metabolism of polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP), a common constituent of tobacco smoke.	Benzo(a)pyrene	165-179	prohibitin 2	Mus musculus	181-184
17397927-1	2007	The behavioral performances of adult mice exposed to sub-acute doses of benzo(a)pyrene (B(a)P) were monitored in tests related to learning and memory (Y maze and Morris water maze), locomotor activity (open-field test) and motor coordination (Locotronic apparatus).	Benzo(a)pyrene	72-86	prohibitin 2	Mus musculus	88-93
16949149-5	2006	In vitro, PGA-CDDP was less potent than free CDDP at inhibiting cell growth in the Bcap-37 cell line.	Cisplatin	14-18	prohibitin 2	Mus musculus	83-90
16949149-6	2006	PGA-CDDP was given as 3 doses at an equivalent CDDP dose of 4 or 12 mg/kg with 2-day intervals between injections to Bcap-37-grafted mice.	pga-cddp	0-8	prohibitin 2	Mus musculus	117-124
16949149-9	2006	PGA-CDDP also increased the survival of mice bearing Bcap-37 cells with reference to PBS treatment or free CDDP treatment.	pga-cddp	0-8	prohibitin 2	Mus musculus	53-60
16949149-9	2006	PGA-CDDP also increased the survival of mice bearing Bcap-37 cells with reference to PBS treatment or free CDDP treatment.	Lead	85-88	prohibitin 2	Mus musculus	53-60
16949149-9	2006	PGA-CDDP also increased the survival of mice bearing Bcap-37 cells with reference to PBS treatment or free CDDP treatment.	Cisplatin	4-8	prohibitin 2	Mus musculus	53-60
15748481-1	2004	OBJECTIVE: To explore the effects of selenium on DNA damage induced by benzo[a] pyrene (BaP) in mouse lung cells.	Selenium	37-45	prohibitin 2	Mus musculus	88-91
15800929-1	2005	Combined subcarcinogenic doses of benzo[a]pyrene (BaP) and UVA induced H-ras, but not p53, gene mutations 8 weeks before tumor emergence in SKH-1 mice.	Benzo(a)pyrene	34-48	prohibitin 2	Mus musculus	50-53
15800929-9	2005	All of the 10-week samples treated with either BaP or BaP-UVA showed detectable mutations at codons 12 and 13, but the genetic load was significantly higher in BaP-UVA-treated mice than in those exposed only to BaP.	uva	58-61	prohibitin 2	Mus musculus	54-57
15800929-9	2005	All of the 10-week samples treated with either BaP or BaP-UVA showed detectable mutations at codons 12 and 13, but the genetic load was significantly higher in BaP-UVA-treated mice than in those exposed only to BaP.	uva	58-61	prohibitin 2	Mus musculus	54-57
15800929-9	2005	All of the 10-week samples treated with either BaP or BaP-UVA showed detectable mutations at codons 12 and 13, but the genetic load was significantly higher in BaP-UVA-treated mice than in those exposed only to BaP.	uva	58-61	prohibitin 2	Mus musculus	54-57
15800929-9	2005	All of the 10-week samples treated with either BaP or BaP-UVA showed detectable mutations at codons 12 and 13, but the genetic load was significantly higher in BaP-UVA-treated mice than in those exposed only to BaP.	uva	164-167	prohibitin 2	Mus musculus	47-50
15800929-9	2005	All of the 10-week samples treated with either BaP or BaP-UVA showed detectable mutations at codons 12 and 13, but the genetic load was significantly higher in BaP-UVA-treated mice than in those exposed only to BaP.	uva	164-167	prohibitin 2	Mus musculus	54-57
15800929-9	2005	All of the 10-week samples treated with either BaP or BaP-UVA showed detectable mutations at codons 12 and 13, but the genetic load was significantly higher in BaP-UVA-treated mice than in those exposed only to BaP.	uva	164-167	prohibitin 2	Mus musculus	54-57
15800929-9	2005	All of the 10-week samples treated with either BaP or BaP-UVA showed detectable mutations at codons 12 and 13, but the genetic load was significantly higher in BaP-UVA-treated mice than in those exposed only to BaP.	uva	164-167	prohibitin 2	Mus musculus	54-57
16392709-1	2005	The prolonging effect of Japanese kelp (kombu) on life span was investigated in mice fed a diet containing the carcinogen benzo[a]pyrene (BaP).	Benzo(a)pyrene	122-136	prohibitin 2	Mus musculus	138-141
15748481-1	2004	OBJECTIVE: To explore the effects of selenium on DNA damage induced by benzo[a] pyrene (BaP) in mouse lung cells.	Benzo(a)pyrene	71-86	prohibitin 2	Mus musculus	88-91
15748481-8	2004	0.75, 1.50 and 3.00 mg/kg of sodium selenite presented antagonistic effects against DNA damage induced by 250 mg/kg of BaP in mouse"s lung cells.	Sodium Selenite	29-44	prohibitin 2	Mus musculus	119-122
15748481-11	2004	0.75 approximately 3.00 mg/kg of sodium selenite could inhibit DNA damage of lung cells in mice induced by 250 mg/kg of BaP.	Sodium Selenite	33-48	prohibitin 2	Mus musculus	120-123
15102951-1	2004	The cytochrome P450 (CYP1A1) enzyme metabolically activates many polycyclic aromatic hydrocarbons, including benzo[a]pyrene (BaP), to DNA- and protein-binding intermediates that are associated with toxicity, mutagenesis, and carcinogenesis.	Polycyclic Aromatic Hydrocarbons	65-97	prohibitin 2	Mus musculus	125-128
15102951-1	2004	The cytochrome P450 (CYP1A1) enzyme metabolically activates many polycyclic aromatic hydrocarbons, including benzo[a]pyrene (BaP), to DNA- and protein-binding intermediates that are associated with toxicity, mutagenesis, and carcinogenesis.	Benzo(a)pyrene	109-123	prohibitin 2	Mus musculus	125-128
14578163-1	2004	Concomitant exposures to arsenic and polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (BaP) are widespread.	Arsenic	25-32	prohibitin 2	Mus musculus	101-104
14578163-1	2004	Concomitant exposures to arsenic and polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (BaP) are widespread.	Polycyclic Aromatic Hydrocarbons	37-69	prohibitin 2	Mus musculus	101-104
14578163-1	2004	Concomitant exposures to arsenic and polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (BaP) are widespread.	Polycyclic Aromatic Hydrocarbons	71-75	prohibitin 2	Mus musculus	101-104
14578163-1	2004	Concomitant exposures to arsenic and polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (BaP) are widespread.	Benzo(a)pyrene	85-99	prohibitin 2	Mus musculus	101-104
14578163-4	2004	A previous in vitro study showed that arsenic potentiated the formation of DNA adducts at low doses of BaP and arsenic.	Arsenic	38-45	prohibitin 2	Mus musculus	103-106
14578163-5	2004	The present study was conducted to test the effect of arsenic on BaP-DNA adduct formation in vivo.	Arsenic	54-61	prohibitin 2	Mus musculus	65-68
14578163-6	2004	We hypothesized that arsenic co-treatment would significantly increase BaP adduct levels in C57BL/6 mouse target organs: skin and lung.	Arsenic	21-28	prohibitin 2	Mus musculus	71-74
14578163-12	2004	Arsenic co-treatment increased average BaP adduct levels in both lung and skin; the increase was statistically significant in the lung (P = 0.038).	Arsenic	0-7	prohibitin 2	Mus musculus	39-42
14578163-13	2004	BaP adduct levels in the skin of individual animals were positively related to skin arsenic concentrations.	Arsenic	84-91	prohibitin 2	Mus musculus	0-3
12884409-1	2003	Benzo[a]pyrene (BaP) is an agonistic ligand for the aryl hydrocarbon receptor (AhR) and a major environmental carcinogen implicated in the aetiology of lung cancer through the induction of benzo[a]pyrene diol epoxidation (BPDE) and BPDE-DNA adducts.	Benzo(a)pyrene	0-14	prohibitin 2	Mus musculus	16-19
12884409-1	2003	Benzo[a]pyrene (BaP) is an agonistic ligand for the aryl hydrocarbon receptor (AhR) and a major environmental carcinogen implicated in the aetiology of lung cancer through the induction of benzo[a]pyrene diol epoxidation (BPDE) and BPDE-DNA adducts.	benzo[a]pyrene diol	189-208	prohibitin 2	Mus musculus	16-19
12884409-1	2003	Benzo[a]pyrene (BaP) is an agonistic ligand for the aryl hydrocarbon receptor (AhR) and a major environmental carcinogen implicated in the aetiology of lung cancer through the induction of benzo[a]pyrene diol epoxidation (BPDE) and BPDE-DNA adducts.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	222-226	prohibitin 2	Mus musculus	16-19
12884409-1	2003	Benzo[a]pyrene (BaP) is an agonistic ligand for the aryl hydrocarbon receptor (AhR) and a major environmental carcinogen implicated in the aetiology of lung cancer through the induction of benzo[a]pyrene diol epoxidation (BPDE) and BPDE-DNA adducts.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	232-236	prohibitin 2	Mus musculus	16-19
12884409-2	2003	Because BaP metabolization requires cytochrome P-450 1A1 (CYP1A1) induction through activation of the AhR, we hypothesized that resveratrol, a natural competitive inhibitor of AhR, could prevent these adverse effects of BaP on the lung.	Resveratrol	128-139	prohibitin 2	Mus musculus	8-11
12884409-2	2003	Because BaP metabolization requires cytochrome P-450 1A1 (CYP1A1) induction through activation of the AhR, we hypothesized that resveratrol, a natural competitive inhibitor of AhR, could prevent these adverse effects of BaP on the lung.	Resveratrol	128-139	prohibitin 2	Mus musculus	220-223
12884409-6	2003	Mice exposed to BaP had a significant induction of lung BPDE-DNA adducts when compared with controls (H scores: control, 26, interquartile range 18-33; BaP, 276, interquartile range 269-288; P < 0.01).	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	56-60	prohibitin 2	Mus musculus	16-19
12884409-7	2003	The BPDE-DNA adduct induction by BaP was abrogated significantly by resveratrol (H score: BaP + resveratrol, 103, interquartile range 96-113).	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	4-8	prohibitin 2	Mus musculus	33-36
12884409-7	2003	The BPDE-DNA adduct induction by BaP was abrogated significantly by resveratrol (H score: BaP + resveratrol, 103, interquartile range 96-113).	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	4-8	prohibitin 2	Mus musculus	90-93
12884409-7	2003	The BPDE-DNA adduct induction by BaP was abrogated significantly by resveratrol (H score: BaP + resveratrol, 103, interquartile range 96-113).	Resveratrol	68-79	prohibitin 2	Mus musculus	33-36
12884409-7	2003	The BPDE-DNA adduct induction by BaP was abrogated significantly by resveratrol (H score: BaP + resveratrol, 103, interquartile range 96-113).	Resveratrol	68-79	prohibitin 2	Mus musculus	90-93
12884409-7	2003	The BPDE-DNA adduct induction by BaP was abrogated significantly by resveratrol (H score: BaP + resveratrol, 103, interquartile range 96-113).	Resveratrol	96-107	prohibitin 2	Mus musculus	33-36
12884409-9	2003	Western blotting confirmed that resveratrol prevented BaP-induced CYP1A1 expression.	Resveratrol	32-43	prohibitin 2	Mus musculus	54-57
12884409-10	2003	This increase in CYP1A1 expression in response to BaP administration most likely causes BaP metabolism, BPDE-DNA adduct formation and subsequent apoptosis.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	104-108	prohibitin 2	Mus musculus	50-53
12884409-11	2003	All BaP-induced effects could be prevented by resveratrol, suggesting a possible chemopreventive role for this natural phytoalexin against the development of lung cancer.	Resveratrol	46-57	prohibitin 2	Mus musculus	4-7
12884409-11	2003	All BaP-induced effects could be prevented by resveratrol, suggesting a possible chemopreventive role for this natural phytoalexin against the development of lung cancer.	phytoalexins	119-130	prohibitin 2	Mus musculus	4-7
12034312-1	2002	Co-exposures to complex mixtures of arsenic and polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) are common in the environment.	Arsenic	36-43	prohibitin 2	Mus musculus	105-108
14556224-8	2003	Benzo[a]pyrene (BaP) exposure increased mutant frequency more than 25-fold above control and did not require an exogenous metabolic activation mixture.	Benzo(a)pyrene	0-14	prohibitin 2	Mus musculus	16-19
14556224-9	2003	Inhibition of Cyp1A1 by 5 microM alpha-naphthoflavone eliminated BaP mutagenesis.	alpha-naphthoflavone	33-53	prohibitin 2	Mus musculus	65-68
12034312-1	2002	Co-exposures to complex mixtures of arsenic and polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) are common in the environment.	Polycyclic Aromatic Hydrocarbons	48-80	prohibitin 2	Mus musculus	105-108
12034312-1	2002	Co-exposures to complex mixtures of arsenic and polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) are common in the environment.	Benzo(a)pyrene	89-103	prohibitin 2	Mus musculus	105-108
12034312-4	2002	We have examined the genotoxicity of BaP-arsenic mixtures.	Arsenic	41-48	prohibitin 2	Mus musculus	37-40
12034312-5	2002	We find that exposure of mouse hepatoma Hepa-1 cells to low concentrations of arsenite increases BaP-DNA adduct levels by as much as 18-fold.	arsenite	78-86	prohibitin 2	Mus musculus	97-100
12034312-6	2002	This effect requires the activation of BaP by cytochrome p450 1A1 (CYP1A1), although arsenite does not alter BaP-inducible CYP1A1 enzymatic activity, suggesting that arsenite acts downstream of metabolic BaP activation.	arsenite	166-174	prohibitin 2	Mus musculus	39-42
12034312-8	2002	In cells depleted of reduced glutathione, arsenite increased BaP-DNA adduct formation by an even greater degree than in cells co-treated with BaP and arsenite in control medium.	arsenite	42-50	prohibitin 2	Mus musculus	61-64
12034312-10	2002	Concentrations of arsenite and BaP that had no measurable mutagenic effect alone, increased mutation frequency at the Hprt locus by eight-fold when given in combination, demonstrating a comutagenic response between BaP and arsenite.	arsenite	18-26	prohibitin 2	Mus musculus	215-218
12034312-10	2002	Concentrations of arsenite and BaP that had no measurable mutagenic effect alone, increased mutation frequency at the Hprt locus by eight-fold when given in combination, demonstrating a comutagenic response between BaP and arsenite.	arsenite	223-231	prohibitin 2	Mus musculus	31-34
11741297-0	2001	Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels.	Benzo(a)pyrene	0-14	prohibitin 2	Mus musculus	110-113
11911489-4	2002	In contrast, pretreatment of CL3 cells with arsenite attenuated BaP cytotoxicity.	arsenite	44-52	prohibitin 2	Mus musculus	64-67
11741297-1	2001	Previous studies have shown that cytochrome P450 1A1 (CYP1A1), CYP1B1, and prostaglandin-endoperoxide synthase (PTGS2) are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), and all three metabolize BaP to reactive DNA-binding intermediates and excreted products.	Benzo(a)pyrene	136-150	prohibitin 2	Mus musculus	152-155
11741297-1	2001	Previous studies have shown that cytochrome P450 1A1 (CYP1A1), CYP1B1, and prostaglandin-endoperoxide synthase (PTGS2) are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), and all three metabolize BaP to reactive DNA-binding intermediates and excreted products.	Benzo(a)pyrene	136-150	prohibitin 2	Mus musculus	238-241
11741297-1	2001	Previous studies have shown that cytochrome P450 1A1 (CYP1A1), CYP1B1, and prostaglandin-endoperoxide synthase (PTGS2) are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), and all three metabolize BaP to reactive DNA-binding intermediates and excreted products.	Polychlorinated Dibenzodioxins	161-196	prohibitin 2	Mus musculus	152-155
11741297-1	2001	Previous studies have shown that cytochrome P450 1A1 (CYP1A1), CYP1B1, and prostaglandin-endoperoxide synthase (PTGS2) are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), and all three metabolize BaP to reactive DNA-binding intermediates and excreted products.	Polychlorinated Dibenzodioxins	161-196	prohibitin 2	Mus musculus	238-241
11741297-1	2001	Previous studies have shown that cytochrome P450 1A1 (CYP1A1), CYP1B1, and prostaglandin-endoperoxide synthase (PTGS2) are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), and all three metabolize BaP to reactive DNA-binding intermediates and excreted products.	Polychlorinated Dibenzodioxins	198-202	prohibitin 2	Mus musculus	152-155
11741297-1	2001	Previous studies have shown that cytochrome P450 1A1 (CYP1A1), CYP1B1, and prostaglandin-endoperoxide synthase (PTGS2) are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), and all three metabolize BaP to reactive DNA-binding intermediates and excreted products.	Polychlorinated Dibenzodioxins	198-202	prohibitin 2	Mus musculus	238-241
11741297-1	2001	Previous studies have shown that cytochrome P450 1A1 (CYP1A1), CYP1B1, and prostaglandin-endoperoxide synthase (PTGS2) are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), and all three metabolize BaP to reactive DNA-binding intermediates and excreted products.	Dioxins	190-196	prohibitin 2	Mus musculus	152-155
11741297-1	2001	Previous studies have shown that cytochrome P450 1A1 (CYP1A1), CYP1B1, and prostaglandin-endoperoxide synthase (PTGS2) are inducible by benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin), and all three metabolize BaP to reactive DNA-binding intermediates and excreted products.	Dioxins	190-196	prohibitin 2	Mus musculus	238-241
11741297-5	2001	We found that a single 500 mg/kg dose of BaP induces hepatic CYP1A1 mRNA, protein, and enzyme activity in Cyp1a1(+/-) but not in Cyp1a1(-/-) mice; TCDD pretreatment increases further the CYP1A1 in Cyp1a1(+/-) but not Cyp1a1(-/-) mice.	Polychlorinated Dibenzodioxins	147-151	prohibitin 2	Mus musculus	41-44
11741297-7	2001	Unexpectedly, we found 4-fold higher BaP-DNA adduct levels in Cyp1a1(-/-) than in Cyp1a1(+/-) mice; TCDD pretreatment lowered the levels of BaP-DNA adducts in both genotypes, suggesting the involvement of other TCDD-inducible detoxification enzymes.	Polychlorinated Dibenzodioxins	100-104	prohibitin 2	Mus musculus	37-40
11741297-7	2001	Unexpectedly, we found 4-fold higher BaP-DNA adduct levels in Cyp1a1(-/-) than in Cyp1a1(+/-) mice; TCDD pretreatment lowered the levels of BaP-DNA adducts in both genotypes, suggesting the involvement of other TCDD-inducible detoxification enzymes.	Polychlorinated Dibenzodioxins	100-104	prohibitin 2	Mus musculus	140-143
11741297-7	2001	Unexpectedly, we found 4-fold higher BaP-DNA adduct levels in Cyp1a1(-/-) than in Cyp1a1(+/-) mice; TCDD pretreatment lowered the levels of BaP-DNA adducts in both genotypes, suggesting the involvement of other TCDD-inducible detoxification enzymes.	Polychlorinated Dibenzodioxins	211-215	prohibitin 2	Mus musculus	140-143
8676899-1	1996	The purpose of this study was to investigate the influence of benzylisothiocyanate (BIT) and 13-cis-retinoic acid (RA) upon the genotoxic potential of benzo[a]pyrene (BaP) to induce micronucleus formation in the bone marrow of mice.	benzyl isothiocyanate	62-82	prohibitin 2	Mus musculus	167-170
10856296-1	2000	During previous studies, we found that mdm2 mRNA levels were elevated in benzo[a]pyrene (BaP, a polycyclic aryl hydrocarbon)-treated cells under conditions of DNA damage-induced cell cycle arrest (Vaziri, C., and Faller, D. V. (1997) J. Biol.	Benzo(a)pyrene	73-87	prohibitin 2	Mus musculus	89-92
10856296-1	2000	During previous studies, we found that mdm2 mRNA levels were elevated in benzo[a]pyrene (BaP, a polycyclic aryl hydrocarbon)-treated cells under conditions of DNA damage-induced cell cycle arrest (Vaziri, C., and Faller, D. V. (1997) J. Biol.	polycyclic aryl hydrocarbon	96-123	prohibitin 2	Mus musculus	89-92
10856296-5	2000	However, we show that induction of mdm2 mRNA by BaP is entirely dependent upon aryl-hydrocarbon-induced genotoxicity and does not involve direct aryl-hydrocarbon receptor-mediated transcriptional activation of the mdm2 gene.	aryl	79-83	prohibitin 2	Mus musculus	48-51
10856296-5	2000	However, we show that induction of mdm2 mRNA by BaP is entirely dependent upon aryl-hydrocarbon-induced genotoxicity and does not involve direct aryl-hydrocarbon receptor-mediated transcriptional activation of the mdm2 gene.	Hydrocarbons	84-95	prohibitin 2	Mus musculus	48-51
9639691-12	1998	Finally, it could be demonstrated that the number of BaP or CP induced micronuclei in polychromatic erythrocytes in bone-marrow of mice was reduced significantly by the carotenoids lycopene, canthaxanthin, lutein and beta-cryptoxanthin (25-46%).	Carotenoids	169-180	prohibitin 2	Mus musculus	53-56
9639691-12	1998	Finally, it could be demonstrated that the number of BaP or CP induced micronuclei in polychromatic erythrocytes in bone-marrow of mice was reduced significantly by the carotenoids lycopene, canthaxanthin, lutein and beta-cryptoxanthin (25-46%).	Lycopene	181-189	prohibitin 2	Mus musculus	53-56
9639691-12	1998	Finally, it could be demonstrated that the number of BaP or CP induced micronuclei in polychromatic erythrocytes in bone-marrow of mice was reduced significantly by the carotenoids lycopene, canthaxanthin, lutein and beta-cryptoxanthin (25-46%).	Canthaxanthin	191-204	prohibitin 2	Mus musculus	53-56
9639691-12	1998	Finally, it could be demonstrated that the number of BaP or CP induced micronuclei in polychromatic erythrocytes in bone-marrow of mice was reduced significantly by the carotenoids lycopene, canthaxanthin, lutein and beta-cryptoxanthin (25-46%).	Beta-Cryptoxanthin	217-235	prohibitin 2	Mus musculus	53-56
11499694-8	2001	benzo-[a]-pyrene (BaP), PCB (polychlorinated biphenyl) congeners) environmental chemicals indicated that hematopoietic or stromal bone marrow cells were targets for most of the chemicals.	Benzo(a)pyrene	0-16	prohibitin 2	Mus musculus	18-21
10873718-4	2000	Twice weekly, for 38 weeks, topical application of NO-NTA at the concentration of 250 nmol to mice previously initiated with benzo(a)pyrene (BaP) caused 90% tumor incidence.	N-nitroso-N-(3-keto-1,2-butanediol)-3'-nitrotyramine	51-57	prohibitin 2	Mus musculus	141-144
10873718-4	2000	Twice weekly, for 38 weeks, topical application of NO-NTA at the concentration of 250 nmol to mice previously initiated with benzo(a)pyrene (BaP) caused 90% tumor incidence.	Benzo(a)pyrene	125-139	prohibitin 2	Mus musculus	141-144
8676899-1	1996	The purpose of this study was to investigate the influence of benzylisothiocyanate (BIT) and 13-cis-retinoic acid (RA) upon the genotoxic potential of benzo[a]pyrene (BaP) to induce micronucleus formation in the bone marrow of mice.	benzyl isothiocyanate	84-87	prohibitin 2	Mus musculus	167-170
8676899-1	1996	The purpose of this study was to investigate the influence of benzylisothiocyanate (BIT) and 13-cis-retinoic acid (RA) upon the genotoxic potential of benzo[a]pyrene (BaP) to induce micronucleus formation in the bone marrow of mice.	Isotretinoin	93-113	prohibitin 2	Mus musculus	167-170
8676899-1	1996	The purpose of this study was to investigate the influence of benzylisothiocyanate (BIT) and 13-cis-retinoic acid (RA) upon the genotoxic potential of benzo[a]pyrene (BaP) to induce micronucleus formation in the bone marrow of mice.	Isotretinoin	115-117	prohibitin 2	Mus musculus	167-170
8676899-1	1996	The purpose of this study was to investigate the influence of benzylisothiocyanate (BIT) and 13-cis-retinoic acid (RA) upon the genotoxic potential of benzo[a]pyrene (BaP) to induce micronucleus formation in the bone marrow of mice.	Benzo(a)pyrene	151-165	prohibitin 2	Mus musculus	167-170
8676899-9	1996	The results showed that both BIT and RA significantly reduced the frequency of micronucleus formation in the bone marrow of the BaP treated animals.	Isotretinoin	37-39	prohibitin 2	Mus musculus	128-131
8804551-0	1996	Effect of dietary restriction on benzo[a]pyrene (BaP) metabolic activation and pulmonary BaP-DNA adduct formation in mouse.	Benzo(a)pyrene	33-47	prohibitin 2	Mus musculus	49-52
8804551-7	1996	The formation of the specific BaP-N2-dG adducts, measured by 32P-postlabeling, was only 20% of the total [3H]BaP-DNA adducts as determined by liquid scintillation counting.	Phosphorus-32	61-64	prohibitin 2	Mus musculus	30-33
8804551-4	1996	The effects of DR on the formation of the specific BaP-DNA adduct, 10-(N2-deoxyguanosinyl)-7,8,9-trihydroxy-7,8,9,10-tetrahydro-BaP (BaP-N2-dG) in mouse lung can be detected by using 32P-postlabeling technique.	Phosphorus-32	183-186	prohibitin 2	Mus musculus	51-54
8804551-5	1996	In both AL- and DR-mice total BaP-DNA adduct formation in lung reached a peak at 48 hours after treatment with [3H]BaP and the in vivo formation of BaP-N2-dG was greater in DR mouse lung than in that of AL-animals by 22%.	Aluminum	8-10	prohibitin 2	Mus musculus	30-33
8804551-5	1996	In both AL- and DR-mice total BaP-DNA adduct formation in lung reached a peak at 48 hours after treatment with [3H]BaP and the in vivo formation of BaP-N2-dG was greater in DR mouse lung than in that of AL-animals by 22%.	Aluminum	8-10	prohibitin 2	Mus musculus	115-118
8804551-5	1996	In both AL- and DR-mice total BaP-DNA adduct formation in lung reached a peak at 48 hours after treatment with [3H]BaP and the in vivo formation of BaP-N2-dG was greater in DR mouse lung than in that of AL-animals by 22%.	Aluminum	8-10	prohibitin 2	Mus musculus	115-118
8804551-5	1996	In both AL- and DR-mice total BaP-DNA adduct formation in lung reached a peak at 48 hours after treatment with [3H]BaP and the in vivo formation of BaP-N2-dG was greater in DR mouse lung than in that of AL-animals by 22%.	Tritium	112-114	prohibitin 2	Mus musculus	30-33
8804551-5	1996	In both AL- and DR-mice total BaP-DNA adduct formation in lung reached a peak at 48 hours after treatment with [3H]BaP and the in vivo formation of BaP-N2-dG was greater in DR mouse lung than in that of AL-animals by 22%.	Tritium	112-114	prohibitin 2	Mus musculus	115-118
8804551-5	1996	In both AL- and DR-mice total BaP-DNA adduct formation in lung reached a peak at 48 hours after treatment with [3H]BaP and the in vivo formation of BaP-N2-dG was greater in DR mouse lung than in that of AL-animals by 22%.	Tritium	112-114	prohibitin 2	Mus musculus	115-118
8001227-18	1994	A combination of benzyl isothiocyanate and phenethyl isothiocyanate, given 2 h prior to each gavage of NNK and BaP, was found to be an effective inhibitor of lung tumor formation, reducing the tumor multiplicity to 5.9 +/- 5.7 lung adenomas/mouse (P < 0.001) and completely inhibiting forestomach tumor development.	benzyl isothiocyanate	17-38	prohibitin 2	Mus musculus	103-114
8001227-18	1994	A combination of benzyl isothiocyanate and phenethyl isothiocyanate, given 2 h prior to each gavage of NNK and BaP, was found to be an effective inhibitor of lung tumor formation, reducing the tumor multiplicity to 5.9 +/- 5.7 lung adenomas/mouse (P < 0.001) and completely inhibiting forestomach tumor development.	phenethyl isothiocyanate	43-67	prohibitin 2	Mus musculus	103-114
8097600-1	1993	The immunotoxic effects of the environmental carcinogen benzo[a]pyrene (BaP) have been evaluated using mouse, but not human, lymphocytes.	Benzo(a)pyrene	56-70	prohibitin 2	Mus musculus	72-75
8075628-1	1994	The micronucleus test (MNT) was applied in the epithelial cells from the bladder of mice treated with benzo(a)pyrene (BaP), 2-acetylaminofluorene (2-AAF) and cyclophosphamide (CP).	Benzo(a)pyrene	102-116	prohibitin 2	Mus musculus	118-121
1620268-3	1992	In behavioral studies BAP was able to antagonize the QNB-induced hyperactivity in mice; however, BAP did not appear to alter nicotine-induced seizure activity or other behavioral effects in mice.	Quinuclidinyl Benzilate	53-56	prohibitin 2	Mus musculus	22-25
1412470-1	1992	Recent studies have demonstrated that macrophages are the cell types capable of metabolizing benzo[a]pyrene (B(a)P) within the spleens of untreated mice.	Benzo(a)pyrene	93-107	prohibitin 2	Mus musculus	109-114
1412470-5	1992	Cells were incubated with [3H]B(a)P for 24 hr.	Tritium	27-29	prohibitin 2	Mus musculus	30-35
1412470-8	1992	The three major metabolites produced were an unidentified peak of polar metabolites containing polyhydroxylated metabolites, B(a)P-9,10- and B(a)P-7,8-dihydrodiols.	7,8-dihydrodiols	147-163	prohibitin 2	Mus musculus	141-146
1525345-7	1992	The decreased amount of BaP bound to DNA of epidermic and dermic cells may be similar and 90% of (+) anti BPDE-dG was removed after a week of treatment; in addition, a minority that bound with 9OH-BaP was also shown to be persistent.	7,8-dihydroxy-9,10-epoxide-7,8,9,10-tetrahydrobenzo(a)pyrene-10-deoxyguanosine	106-113	prohibitin 2	Mus musculus	24-27
1620268-4	1992	A plot of the time course of inhibition by BAP for [3H]QNB binding revealed that the inhibition was almost complete within 10 min exposure at 37 degrees.	3-quinuclidinyl 4-fluoromethylbenzilate	51-58	prohibitin 2	Mus musculus	43-46
34435719-7	2021	Moreover, after H2 O2 treatment the mitophagy is activated and the PHB2 expression is increased.	Hydrogen Peroxide	16-21	prohibitin 2	Mus musculus	67-71
33824698-6	2021	TAC (four and eight weeks) elevated the phosphorylation of signal transducer and activator of transcription 3 (p-STAT3) and prohibitin2 (PHB2) protein expression.	tac	0-3	prohibitin 2	Mus musculus	124-135
33824698-6	2021	TAC (four and eight weeks) elevated the phosphorylation of signal transducer and activator of transcription 3 (p-STAT3) and prohibitin2 (PHB2) protein expression.	tac	0-3	prohibitin 2	Mus musculus	137-141
34358595-4	2021	Hematoxylin and eosin staining, Annexin V-FITC/PI staining, and mitochondrial membrane potential analysis demonstrated that BAP could induce the apoptosis of S180 tumor cells.	Hematoxylin	0-11	prohibitin 2	Mus musculus	124-127
34358595-1	2021	A polysaccharide from the aqueous extract of Boletus aereus fruit (BAP) was isolated.	Polysaccharides	2-16	prohibitin 2	Mus musculus	67-70
34358595-4	2021	Hematoxylin and eosin staining, Annexin V-FITC/PI staining, and mitochondrial membrane potential analysis demonstrated that BAP could induce the apoptosis of S180 tumor cells.	Eosine Yellowish-(YS)	16-21	prohibitin 2	Mus musculus	124-127
34358595-6	2021	Furthermore, a novel polysaccharide, namely, BAPF, was purified from BAP by using DEAE Cellulose-52 column and Sephadex G-100 gel column.	Polysaccharides	21-35	prohibitin 2	Mus musculus	69-72
34358595-6	2021	Furthermore, a novel polysaccharide, namely, BAPF, was purified from BAP by using DEAE Cellulose-52 column and Sephadex G-100 gel column.	bapf	45-49	prohibitin 2	Mus musculus	69-72
35567930-1	2022	BACKGROUND: Benzo(a)pyrene (BaP), a toxic carcinogen, is associated with various adverse effects but is rarely discussed in muscle-related disorders.	Benzo(a)pyrene	12-26	prohibitin 2	Mus musculus	28-31
34332006-1	2021	BACKGROUND: Previous work indicated that benzo(a)pyrene (B(a)P) exposure in utero might adversely affect neurodevelopment and cause Parkinson"s Disease (PD)-like symptoms.	Benzo(a)pyrene	41-55	prohibitin 2	Mus musculus	57-62
35567930-8	2022	In addition, N-acetylcysteine, a well-known antioxidant, led to decrease in oxidative markers induced by BaP.	Acetylcysteine	13-29	prohibitin 2	Mus musculus	105-108
35149188-0	2022	MicroRNA-24-3p alleviates cardiac fibrosis by suppressing cardiac fibroblasts mitophagy via downregulating PHB2.	microrna-24-3p	0-14	prohibitin 2	Mus musculus	107-111
2778258-1	1989	To study the dermal penetration of benzo[a]pyrene (BAP) in relation to other polycyclic aromatic hydrocarbons (PAHs), a complex mixture of PAHs was applied to the backs of CD-1 mice, and the dermal residence times of BAP and eleven other PAHs were determined using gas chromatography.	Benzo(a)pyrene	35-49	prohibitin 2	Mus musculus	51-54
2711409-1	1989	Coal-derived complex organic mixtures [COM] with boiling points greater than or equal to 370 degrees C (greater than or equal to 700 degrees F) are known to inhibit both mouse skin tumor initiation by benzo[a]pyrene [BAP], and BAP-induced bacterial mutagenesis.	pyrene	209-215	prohibitin 2	Mus musculus	217-220
3115566-1	1987	Whereas extensive evidence indicates that 7 beta,8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (anti-BPDE) is a major ultimate carcinogen of benzo(a)pyrene (BaP) in mouse skin, tumorigenicity studies have consistently shown that anti-BPDE is less active then BaP in this model system.	7 beta,8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene	42-124	prohibitin 2	Mus musculus	187-190
2835829-9	1988	Studies which included benzo[a]pyrene (BaP) as a control xenobiotic known to demonstrate Ah dependence showed that the MLR of splenic lymphocytes from Ah-congenic mice was comparably suppressed following 40 microM DMBA exposure, whereas exposure to 40 microM BaP resulted in suppression of the MLR only in B6-Ah(b)Ah(d) splenocytes.	Benzo(a)pyrene	23-37	prohibitin 2	Mus musculus	39-42
2835829-9	1988	Studies which included benzo[a]pyrene (BaP) as a control xenobiotic known to demonstrate Ah dependence showed that the MLR of splenic lymphocytes from Ah-congenic mice was comparably suppressed following 40 microM DMBA exposure, whereas exposure to 40 microM BaP resulted in suppression of the MLR only in B6-Ah(b)Ah(d) splenocytes.	9,10-Dimethyl-1,2-benzanthracene	214-218	prohibitin 2	Mus musculus	39-42
2835829-9	1988	Studies which included benzo[a]pyrene (BaP) as a control xenobiotic known to demonstrate Ah dependence showed that the MLR of splenic lymphocytes from Ah-congenic mice was comparably suppressed following 40 microM DMBA exposure, whereas exposure to 40 microM BaP resulted in suppression of the MLR only in B6-Ah(b)Ah(d) splenocytes.	9,10-Dimethyl-1,2-benzanthracene	214-218	prohibitin 2	Mus musculus	259-262
3131261-1	1988	The capacity of lymphocytes from C57Bl/6 X C3H/HeN F1 (B6C3F1) mice to proliferate in vitro following exposure to benzo(a)pyrene (BaP) in vivo or in vitro was examined.	Benzo(a)pyrene	114-128	prohibitin 2	Mus musculus	130-133
2748687-4	1989	Mechanistic studies suggest that catechol affects BaP metabolism and especially secondary oxidation reactions of this carcinogen and thus changes the proportion of BPDE-DNA adducts.	catechol	33-41	prohibitin 2	Mus musculus	50-53
2748687-4	1989	Mechanistic studies suggest that catechol affects BaP metabolism and especially secondary oxidation reactions of this carcinogen and thus changes the proportion of BPDE-DNA adducts.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	164-168	prohibitin 2	Mus musculus	50-53
2748687-5	1989	Comparison of the disposition and metabolism of BaP and its ultimate carcinogenic derivative, anti-BPDE, in mouse epidermis demonstrates that the lower activity of BPDE relative to BaP in mouse skin is partially due to differences in penetration and trapping of BPDE within the epidermis, where it is protected from hydrolysis and reaction with intracellular macromolecules.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	99-103	prohibitin 2	Mus musculus	48-51
2748687-5	1989	Comparison of the disposition and metabolism of BaP and its ultimate carcinogenic derivative, anti-BPDE, in mouse epidermis demonstrates that the lower activity of BPDE relative to BaP in mouse skin is partially due to differences in penetration and trapping of BPDE within the epidermis, where it is protected from hydrolysis and reaction with intracellular macromolecules.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	164-168	prohibitin 2	Mus musculus	48-51
2748687-5	1989	Comparison of the disposition and metabolism of BaP and its ultimate carcinogenic derivative, anti-BPDE, in mouse epidermis demonstrates that the lower activity of BPDE relative to BaP in mouse skin is partially due to differences in penetration and trapping of BPDE within the epidermis, where it is protected from hydrolysis and reaction with intracellular macromolecules.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	164-168	prohibitin 2	Mus musculus	48-51
3146411-6	1988	It should be pointed out that singlet oxygen can be generated via enzymatic reactions in the dark and thus might play a role in the formation of the ultimate carcinogenic metabolite B(a)P-7, 8-dihydroxy-9, 10-epoxide.	Singlet Oxygen	30-44	prohibitin 2	Mus musculus	182-187
3146411-6	1988	It should be pointed out that singlet oxygen can be generated via enzymatic reactions in the dark and thus might play a role in the formation of the ultimate carcinogenic metabolite B(a)P-7, 8-dihydroxy-9, 10-epoxide.	7, 8-dihydroxy-9, 10-epoxide	188-216	prohibitin 2	Mus musculus	182-187
3115566-1	1987	Whereas extensive evidence indicates that 7 beta,8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (anti-BPDE) is a major ultimate carcinogen of benzo(a)pyrene (BaP) in mouse skin, tumorigenicity studies have consistently shown that anti-BPDE is less active then BaP in this model system.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	131-135	prohibitin 2	Mus musculus	187-190
3115566-1	1987	Whereas extensive evidence indicates that 7 beta,8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (anti-BPDE) is a major ultimate carcinogen of benzo(a)pyrene (BaP) in mouse skin, tumorigenicity studies have consistently shown that anti-BPDE is less active then BaP in this model system.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	131-135	prohibitin 2	Mus musculus	289-292
3115566-1	1987	Whereas extensive evidence indicates that 7 beta,8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (anti-BPDE) is a major ultimate carcinogen of benzo(a)pyrene (BaP) in mouse skin, tumorigenicity studies have consistently shown that anti-BPDE is less active then BaP in this model system.	Benzo(a)pyrene	110-124	prohibitin 2	Mus musculus	187-190
3115566-1	1987	Whereas extensive evidence indicates that 7 beta,8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (anti-BPDE) is a major ultimate carcinogen of benzo(a)pyrene (BaP) in mouse skin, tumorigenicity studies have consistently shown that anti-BPDE is less active then BaP in this model system.	Benzo(a)pyrene	110-124	prohibitin 2	Mus musculus	289-292
3115566-2	1987	In order to investigate factors responsible for this apparent contradiction, we have compared the disposition, metabolism, and DNA binding of [3H]BaP, (+/-)-trans-7,8-[14C]dihydroxy-7,8-dihydrobenzo(a)pyrene [(+/-)-[14C]BaP-7,8-diol), and (+/-)-anti-[3H]BPDE in mouse epidermis in vivo.	(+/-)-anti-[3h]bpde	239-258	prohibitin 2	Mus musculus	146-149
3115566-5	1987	However, 60-65% of anti-BPDE disappeared from mouse epidermis within 3 min of application, while a second slower phase of removal of radioactivity was observed between 8 min and 2 h. The kinetics of removal of BaP-7,8-diol and its metabolites were intermediate between those of BaP and anti-BPDE.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	24-28	prohibitin 2	Mus musculus	210-213
3115566-5	1987	However, 60-65% of anti-BPDE disappeared from mouse epidermis within 3 min of application, while a second slower phase of removal of radioactivity was observed between 8 min and 2 h. The kinetics of removal of BaP-7,8-diol and its metabolites were intermediate between those of BaP and anti-BPDE.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	291-295	prohibitin 2	Mus musculus	210-213
6297825-1	1983	Benzo[a]pyrene (BaP) is metabolized to the chemically reactive anti and syn isomers of the 7,8-diol-9,10-epoxides of BaP (BPDE) which bind covalently to DNA to form DNA/BPDE complexes.	7,8-diol-9,10-epoxides	91-113	prohibitin 2	Mus musculus	16-19
3769749-1	1986	In mutagenicity and carcinogenicity assays using micronucleus test, N-methyl-N"-nitro-N-nitrosoguanidine (MNNG), 50 mg/kg or benzo(a)pyrene (BaP), 100 mg/kg did not increase the incidence of micronuclei in polychromatic erythrocytes in bone marrow of mice.	Benzo(a)pyrene	125-139	prohibitin 2	Mus musculus	141-144
4061096-1	1985	The metabolism of benzo(a)pyrene (BaP) was studied in isolated perfused and ventilated lungs from two inbred strains of mice.	Benzo(a)pyrene	18-32	prohibitin 2	Mus musculus	34-37
4061096-3	1985	BaP metabolism was quantified by the rate of appearance of free and conjugated 14C-metabolites released into the perfusion medium, and the production of nonextractable metabolites covalently bound to lung macromolecules.	Carbon-14	79-82	prohibitin 2	Mus musculus	0-3
3975919-1	1985	Mild acid hydrolysis of globin preparations from erythrocytes of mice, previously exposed topically to benzo[a]pyrene (BaP), releases tetrols which are detectable by HPLC/fluorescence analysis.	Benzo(a)pyrene	103-117	prohibitin 2	Mus musculus	119-122
3975919-1	1985	Mild acid hydrolysis of globin preparations from erythrocytes of mice, previously exposed topically to benzo[a]pyrene (BaP), releases tetrols which are detectable by HPLC/fluorescence analysis.	tetrols	134-141	prohibitin 2	Mus musculus	119-122
3975919-2	1985	If the mouse is exposed to radiolabelled BaP, radioactivity can be found in the acid-releasable tetrols.	tetrols	96-103	prohibitin 2	Mus musculus	41-44
3975919-6	1985	The amount of anti-benzo[a]pyrene diol epoxide (anti-BaPDE) binding to DNA and hemoglobin at various doses of BaP appears to be qualitatively similar.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	19-46	prohibitin 2	Mus musculus	53-56
6297825-1	1983	Benzo[a]pyrene (BaP) is metabolized to the chemically reactive anti and syn isomers of the 7,8-diol-9,10-epoxides of BaP (BPDE) which bind covalently to DNA to form DNA/BPDE complexes.	Benzo(a)pyrene	0-14	prohibitin 2	Mus musculus	117-120
6297825-1	1983	Benzo[a]pyrene (BaP) is metabolized to the chemically reactive anti and syn isomers of the 7,8-diol-9,10-epoxides of BaP (BPDE) which bind covalently to DNA to form DNA/BPDE complexes.	Benzo(a)pyrene	0-14	prohibitin 2	Mus musculus	16-19
6297825-1	1983	Benzo[a]pyrene (BaP) is metabolized to the chemically reactive anti and syn isomers of the 7,8-diol-9,10-epoxides of BaP (BPDE) which bind covalently to DNA to form DNA/BPDE complexes.	7,8-diol-9,10-epoxides	91-113	prohibitin 2	Mus musculus	117-120
6297825-1	1983	Benzo[a]pyrene (BaP) is metabolized to the chemically reactive anti and syn isomers of the 7,8-diol-9,10-epoxides of BaP (BPDE) which bind covalently to DNA to form DNA/BPDE complexes.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	122-126	prohibitin 2	Mus musculus	16-19
6297825-1	1983	Benzo[a]pyrene (BaP) is metabolized to the chemically reactive anti and syn isomers of the 7,8-diol-9,10-epoxides of BaP (BPDE) which bind covalently to DNA to form DNA/BPDE complexes.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	122-126	prohibitin 2	Mus musculus	117-120
6297825-1	1983	Benzo[a]pyrene (BaP) is metabolized to the chemically reactive anti and syn isomers of the 7,8-diol-9,10-epoxides of BaP (BPDE) which bind covalently to DNA to form DNA/BPDE complexes.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	169-173	prohibitin 2	Mus musculus	16-19
6297825-1	1983	Benzo[a]pyrene (BaP) is metabolized to the chemically reactive anti and syn isomers of the 7,8-diol-9,10-epoxides of BaP (BPDE) which bind covalently to DNA to form DNA/BPDE complexes.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	169-173	prohibitin 2	Mus musculus	117-120
6297825-6	1983	With mouse skin in organ culture it could be demonstrated that: (i) upon a single topical application of 5 micrograms of BaP, binding to DNA occurred via BPDE at a linear rate for up to 65 h, (ii) the amount of binding was dose dependent at concentrations of BaP less than 10 micrograms.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	154-158	prohibitin 2	Mus musculus	121-124
6133387-2	1983	When mice were exposed to PCBs through the diet and to benzo-(a)-pyrene (BAP) by topical application, hyperkeratinization occurred in the epidermis and hyperkeratinized cysts occasionally formed, but alterations were also observed in the dermis and in small cutaneous blood vessels, particularly capillaries and venules.	Polychlorinated Biphenyls	26-30	prohibitin 2	Mus musculus	73-76
6282446-2	1982	The formation of both organic and water-soluble metabolites during the 48-hr period increased proportionally with time, except in the case of BaP phenols, which increased initially but then remained the same or decreased.	Phenols	146-153	prohibitin 2	Mus musculus	142-145
6282446-5	1982	The nature of the BaP water-soluble derivatives produced by the C3H/10T 1/2 and CVP cell lines was investigated by hydrolysis of culture medium with beta-glucuronidase and arylsulfatase.	Water	22-27	prohibitin 2	Mus musculus	18-21
6282446-6	1982	Although sulfation was not a major conjugation pathway for BaP in these cells, glucuronidation of BaP phenols was found to account for 30% of the total water-soluble derivatives.	Phenols	102-109	prohibitin 2	Mus musculus	98-101
6282446-6	1982	Although sulfation was not a major conjugation pathway for BaP in these cells, glucuronidation of BaP phenols was found to account for 30% of the total water-soluble derivatives.	Water	152-157	prohibitin 2	Mus musculus	98-101
6282446-7	1982	The similarity in the kinetics and qualitative nature of the metabolism of BaP by C3H/10T 1/2 and CVP cells indicates that both cell lines are equally capable of biosynthesizing the proximal carcinogen, 7,8-trans-dihydroxy-7,8-dihydrobenzo(a)pyrene.	7,8-trans-dihydroxy-7,8-dihydrobenzo(a)pyrene	203-248	prohibitin 2	Mus musculus	75-78
445457-2	1979	BaP-conjugated epidermal DNA was isolated and enzymatically degraded to deoxyribonucleosides.	Deoxyribonucleosides	72-92	prohibitin 2	Mus musculus	0-3
445457-3	1979	The BaP-DNA adducts were separated by Sephadex LH-20 column or high-performance liquid chromatography.	sephadex	38-52	prohibitin 2	Mus musculus	4-7
33393179-1	2021	Benzo(a)pyrene [B(a)P], which is a carcinogen, is a substance most typically known in cigarette smoke and considered as an important intermediary of lung cancer.	Benzo(a)pyrene	0-14	prohibitin 2	Mus musculus	16-21
106390-3	1979	Hepa-1 was found to be very sensitive to benzo[a]pyrene (BaP) toxicity and a single-step selection procedure for isolating clones resistant to BaP at 4 microgram/ml was designed.	Benzo(a)pyrene	41-55	prohibitin 2	Mus musculus	57-60
599577-1	1977	The effect of respiratory infection by PR8 influenza virus on the elution of bnezo[a]pyrene (BaP) from carbon particles in the respiratory tract of mice was studied.	bnezo[a]pyrene	77-91	prohibitin 2	Mus musculus	93-96
599577-1	1977	The effect of respiratory infection by PR8 influenza virus on the elution of bnezo[a]pyrene (BaP) from carbon particles in the respiratory tract of mice was studied.	Carbon	103-109	prohibitin 2	Mus musculus	93-96
599577-3	1977	If BaP-coated carbon particles are introduced into the respiratory tract during the acute stage of infection, the rate of BaP elution from the carbon particles is increased.	Carbon	14-20	prohibitin 2	Mus musculus	3-6
599577-3	1977	If BaP-coated carbon particles are introduced into the respiratory tract during the acute stage of infection, the rate of BaP elution from the carbon particles is increased.	Carbon	14-20	prohibitin 2	Mus musculus	122-125
599577-3	1977	If BaP-coated carbon particles are introduced into the respiratory tract during the acute stage of infection, the rate of BaP elution from the carbon particles is increased.	Carbon	143-149	prohibitin 2	Mus musculus	3-6
599577-3	1977	If BaP-coated carbon particles are introduced into the respiratory tract during the acute stage of infection, the rate of BaP elution from the carbon particles is increased.	Carbon	143-149	prohibitin 2	Mus musculus	122-125
599577-4	1977	When BaP-coated carbon particles were instilled in the respiratory tract either 1 wk before or 2 wk after the acute stage of infection, the BaP elution rate from carbon particles were similar to that in uninfected animals.	Carbon	16-22	prohibitin 2	Mus musculus	5-8
599577-4	1977	When BaP-coated carbon particles were instilled in the respiratory tract either 1 wk before or 2 wk after the acute stage of infection, the BaP elution rate from carbon particles were similar to that in uninfected animals.	Carbon	16-22	prohibitin 2	Mus musculus	140-143
599577-4	1977	When BaP-coated carbon particles were instilled in the respiratory tract either 1 wk before or 2 wk after the acute stage of infection, the BaP elution rate from carbon particles were similar to that in uninfected animals.	Carbon	162-168	prohibitin 2	Mus musculus	5-8
599577-4	1977	When BaP-coated carbon particles were instilled in the respiratory tract either 1 wk before or 2 wk after the acute stage of infection, the BaP elution rate from carbon particles were similar to that in uninfected animals.	Carbon	162-168	prohibitin 2	Mus musculus	140-143
34037304-0	2021	Glyburide attenuates B(a)p and LPS-induced inflammation-related lung tumorigenesis in mice.	Glyburide	0-9	prohibitin 2	Mus musculus	21-26
34037304-7	2021	While the incidence and mean tumor count of mice in B(a)P/LPS+Gly group were decreased compared with B(a)p/LPS group.	Glyburide	62-65	prohibitin 2	Mus musculus	52-57
34037304-7	2021	While the incidence and mean tumor count of mice in B(a)P/LPS+Gly group were decreased compared with B(a)p/LPS group.	Glyburide	62-65	prohibitin 2	Mus musculus	101-106
34037304-9	2021	The B(a)p/LPS increased the expression of NLRP3, IL-1beta, and Cleaved-IL-1beta protein significantly than Vehicle, whereas decreased in B(a)P/LPS+Gly (0.96 mg/kg) group compared with B(a)p/LPS group.	Glyburide	147-150	prohibitin 2	Mus musculus	4-9
34037304-9	2021	The B(a)p/LPS increased the expression of NLRP3, IL-1beta, and Cleaved-IL-1beta protein significantly than Vehicle, whereas decreased in B(a)P/LPS+Gly (0.96 mg/kg) group compared with B(a)p/LPS group.	Glyburide	147-150	prohibitin 2	Mus musculus	137-142
34037304-10	2021	Results suggested glyburide might inhibit NLRP3 inflammasome to attenuate inflammation-related lung tumorigenesis caused by intratracheal instillation of B(a)p/LPS in non-diabetes mice.	Glyburide	18-27	prohibitin 2	Mus musculus	154-159
33393179-8	2021	Finally, the activity of CYP1A1 and Src in lung tissues from mice supplemented with PCB was noticeably decreased and lower than that in lung tissues from mice supplemented with B(a)P alone.	pinocembrin	84-87	prohibitin 2	Mus musculus	177-182
33393179-5	2021	The aim of this investigation is to examine the potential ability of a flavonoid pinocembrin (PCB) to alleviate B(a)P toxicity and analyze the underlying molecular mechanisms.	flavonoid pinocembrin	71-92	prohibitin 2	Mus musculus	112-117
33393179-5	2021	The aim of this investigation is to examine the potential ability of a flavonoid pinocembrin (PCB) to alleviate B(a)P toxicity and analyze the underlying molecular mechanisms.	pinocembrin	94-97	prohibitin 2	Mus musculus	112-117
33393179-7	2021	PCB mitigated the B(a)P-stimulated DNA damage, inhibited Src and ERK1/2 expression, decreased CYP1A1 expression, and reduced the B(a)P-induced stimulation of NF-kappaB and MAPK signaling in lung epithelial cells.	pinocembrin	0-3	prohibitin 2	Mus musculus	18-23
33393179-7	2021	PCB mitigated the B(a)P-stimulated DNA damage, inhibited Src and ERK1/2 expression, decreased CYP1A1 expression, and reduced the B(a)P-induced stimulation of NF-kappaB and MAPK signaling in lung epithelial cells.	pinocembrin	0-3	prohibitin 2	Mus musculus	129-134
33149573-6	2020	The characterized ZnO-SYR was tested on in vivo mouse model of lung cancer (benzo(a)pyrene (BAP)) and in vitro A549 cells.	zno-syr	18-25	prohibitin 2	Mus musculus	92-95
33254415-7	2021	The estrogen and progesterone levels decreased by B(a)P.	Progesterone	17-29	prohibitin 2	Mus musculus	50-55
33254415-8	2021	In vitro, exposure to BPDE, which is the metabolite of B(a)P, affected the luteinization of granular cell KK-1.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	22-26	prohibitin 2	Mus musculus	55-60
33254415-9	2021	Additionally, melatonin and its receptors, which are important for ovarian function and anti-oxidative damage, were affected by B(a)P or BPDE.	Melatonin	14-23	prohibitin 2	Mus musculus	128-133
33254415-10	2021	B(a)P or BPDE-treated alone impaired antioxidant capacity of ovarian granulosa cells, caused an increasing of ROS and cell apoptosis, and disrupted the PI3K/AKT/GSK3beta signaling pathway in vivo and in vitro.	ros	110-113	prohibitin 2	Mus musculus	0-5
33254415-11	2021	Co-treatment with melatonin alleviated B(a)P or BPDE-induced CL dysfunction by ameliorating oxidative stress, counteracting phosphorylation of PI3K/AKT/GSK3beta signaling pathway, decreasing the apoptosis of the ovarian cells.	Melatonin	18-27	prohibitin 2	Mus musculus	39-44
33254415-13	2021	In conclusion, our findings not only firstly clarify the potential mechanisms of BaP-induced CL dysfunction, but also extend the understanding about the ovarian protection of melatonin and its receptors against B(a)P exposure.	Melatonin	175-184	prohibitin 2	Mus musculus	211-216
33387147-1	2021	We previously showed that fluorizoline, a fluorinated thiazoline compound, binds to both subunits of the mitochondrial prohibitin (PHB) complex, PHB1 and PHB2, being the expression of these proteins required for fluorizoline-induced apoptosis in mouse embryonic fibroblasts.	Fluorizoline	26-38	prohibitin 2	Mus musculus	154-158
33387147-1	2021	We previously showed that fluorizoline, a fluorinated thiazoline compound, binds to both subunits of the mitochondrial prohibitin (PHB) complex, PHB1 and PHB2, being the expression of these proteins required for fluorizoline-induced apoptosis in mouse embryonic fibroblasts.	thiazoline	54-64	prohibitin 2	Mus musculus	154-158
33387147-1	2021	We previously showed that fluorizoline, a fluorinated thiazoline compound, binds to both subunits of the mitochondrial prohibitin (PHB) complex, PHB1 and PHB2, being the expression of these proteins required for fluorizoline-induced apoptosis in mouse embryonic fibroblasts.	Fluorizoline	212-224	prohibitin 2	Mus musculus	154-158
33149573-10	2020	The conclusions of the present study put forward an evident confirmation of the protective and beneficial effects of zincoxide-loaded syringic acid against the BAP-induced lung cancer model.	Zinc Oxide	117-126	prohibitin 2	Mus musculus	160-163
33149573-10	2020	The conclusions of the present study put forward an evident confirmation of the protective and beneficial effects of zincoxide-loaded syringic acid against the BAP-induced lung cancer model.	syringic acid	134-147	prohibitin 2	Mus musculus	160-163
32684523-1	2020	Benzo[a]pyrene(BaP), a polycyclic aromatic hydrocarbons (PAH) of environmental pollutants, is one of the main ingredients in cigarettes and an agonist of the aryl hydrocarbon receptor (AhR).	Benzo(a)pyrene	0-14	prohibitin 2	Mus musculus	15-18
32684523-1	2020	Benzo[a]pyrene(BaP), a polycyclic aromatic hydrocarbons (PAH) of environmental pollutants, is one of the main ingredients in cigarettes and an agonist of the aryl hydrocarbon receptor (AhR).	Polycyclic Aromatic Hydrocarbons	23-55	prohibitin 2	Mus musculus	15-18
32684523-1	2020	Benzo[a]pyrene(BaP), a polycyclic aromatic hydrocarbons (PAH) of environmental pollutants, is one of the main ingredients in cigarettes and an agonist of the aryl hydrocarbon receptor (AhR).	Polycyclic Aromatic Hydrocarbons	57-60	prohibitin 2	Mus musculus	15-18
31177901-10	2020	Finally, a ligand of PHB proteins that we synthesized, called FL3, was found to strongly inhibit PHB2-mediated mitophagy and to effectively block cancer cell growth and energy production at nanomolar concentrations.	fl3	62-65	prohibitin 2	Mus musculus	97-101
31672359-7	2020	Meanwhile, fluoride exposure also increased the expressions of PINK1 and PHB2 in TM3 Leydig cells.	Fluorides	11-19	prohibitin 2	Mus musculus	73-77
31965347-6	2020	In the present study, boron-containing apatite (BAp; Ca9.5+0.5x{(PO4)6-x(BO3)x}{(BO2)1-xOx} (0 <= x <= 1)) was successfully fabricated via the ultrasonic spray-pyrolysis (USSP) route.	Boron	22-27	prohibitin 2	Mus musculus	48-51
31240266-2	2019	We used next-generation sequencing and comparative genomic hybridization arrays to investigate genome-wide mutations in the offspring of male mice exposed to benzo(a)pyrene (BaP), a common environmental pollutant.	Benzo(a)pyrene	158-172	prohibitin 2	Mus musculus	174-177
31626975-5	2019	Significantly, prohibitin proteins (PHB and PHB2) was also regulated by nicotinamide riboside.	nicotinamide-beta-riboside	72-93	prohibitin 2	Mus musculus	44-48
31126972-10	2019	Notably, mutation of Bif-1 at its C-terminal tryptophan-344 not only prevented Bif-1/prohibitin-2 interaction but also reduced prohibitin complex disruption, OPA1 proteolysis, mitochondrial fragmentation, and apoptosis, supporting a pathogenic role of Bif-1/prohibitin-2 interaction.	Tryptophan	45-55	prohibitin 2	Mus musculus	85-97
30942392-5	2019	Using cell proliferation and apoptosis assays, it was demonstrated that benzopyrene (BaP) suppressed the proliferation of mLFCs, and benzanthracene (BaA) and BaP induced cell apoptosis.	Benzopyrenes	72-83	prohibitin 2	Mus musculus	85-88
30614051-3	2019	AAA in male C57BL/6 J mice was induced by coadministration of angiotensin II (Ang II) and 3,4-benzopyrene (BaP).	Benzo(a)pyrene	90-105	prohibitin 2	Mus musculus	107-110
31417980-8	2018	Results: The data revealed that BaP reduces estrogen and progesterone levels, decreases the number of implantation site, endometrium thickness, uterine lumen diameter, stromal cells and endometrial glands, and blood vessels in the endometrium.	Progesterone	57-69	prohibitin 2	Mus musculus	32-35
31417980-10	2018	Conclusion: The finding of this study showed that BaP can change estrogen and progesterone levels, and endometrial morphology leads to impairing the endometrial receptivity and decreasing the number of implantation site.	Progesterone	78-90	prohibitin 2	Mus musculus	50-53
29715546-5	2018	Overexpression of TDP-43 led to an increase in PHB2 whereas TDP-43 knockdown reduced PHB2 expression in cells treated with carbonyl cyanide m-chlorophenylhydrazone (CCCP), an inducer of mitophagy.	Carbonyl Cyanide m-Chlorophenyl Hydrazone	123-163	prohibitin 2	Mus musculus	85-89
29482396-1	2018	Benzo[a]pyrene (BaP) can induce developmental and reproductive toxicity; however, the full scope of its immunotoxic effects remains unknown.	Benzo(a)pyrene	0-14	prohibitin 2	Mus musculus	16-19
31679311-2	2019	Fucoxanthin role in chemoprevention of lung cancer in mouse model induced using benzo(a)pyrene [B(a)P] has been presented here.	fucoxanthin	0-11	prohibitin 2	Mus musculus	96-101
31679311-2	2019	Fucoxanthin role in chemoprevention of lung cancer in mouse model induced using benzo(a)pyrene [B(a)P] has been presented here.	Benzo(a)pyrene	80-94	prohibitin 2	Mus musculus	96-101
31679311-3	2019	Oral administration of fucoxanthin with and without B(a)P were studied, the results from our study shows that fucoxanthin significantly decreased tumor progression in mice exposed to B(a)P, the obtained data were correlated with increased antioxidant, apoptosis and decreased tumour marker and anti-apoptotic molecules.	fucoxanthin	110-121	prohibitin 2	Mus musculus	52-57
31679311-3	2019	Oral administration of fucoxanthin with and without B(a)P were studied, the results from our study shows that fucoxanthin significantly decreased tumor progression in mice exposed to B(a)P, the obtained data were correlated with increased antioxidant, apoptosis and decreased tumour marker and anti-apoptotic molecules.	fucoxanthin	110-121	prohibitin 2	Mus musculus	183-188
31679311-5	2019	Finally, histopathological and immuno histochemical analysis also revealed that fucoxanthin shows potent anticancer agent by bringing back the damaged tissue treated with B(a)P and also decreases the expression of PCNA in cancer induced mice.	fucoxanthin	80-91	prohibitin 2	Mus musculus	171-176
29368147-1	2018	Benzo[a]pyrene (BaP) is an environmental pollutant that, based on evidence largely from in vitro studies, exerts its genotoxic effects after metabolic activation by cytochrome P450s.	Benzo(a)pyrene	0-14	prohibitin 2	Mus musculus	16-19
29197069-5	2018	In this study, we investigated the preventive effect of PMFs on benzo[a]pyrene/dextran sulfate sodium (BaP/DSS)-induced colorectal tumorigenesis in ICR mice.	benzo[a]pyrene/dextran sulfate sodium	64-101	prohibitin 2	Mus musculus	103-106
29368147-8	2018	Adduct formation (i.e. 10-(deoxyguanosin-N2-yl)-7,8,9-trihydroxy-7,8,9,10-tetrahydro-BaP [dG-N2-BPDE]) correlated with observed CYP1A activity and metabolite formation (i.e. BaP-7,8-dihydrodiol) when NADPH or NADH was used as enzymatic cofactors.	NAD	209-213	prohibitin 2	Mus musculus	85-88
29368147-8	2018	Adduct formation (i.e. 10-(deoxyguanosin-N2-yl)-7,8,9-trihydroxy-7,8,9,10-tetrahydro-BaP [dG-N2-BPDE]) correlated with observed CYP1A activity and metabolite formation (i.e. BaP-7,8-dihydrodiol) when NADPH or NADH was used as enzymatic cofactors.	NADP	200-205	prohibitin 2	Mus musculus	85-88
29368147-9	2018	BaP-DNA adduct levels (i.e. dG-N2-BPDE) in vivo were significantly higher (~ sevenfold) in liver of HRN mice than WT mice while no significant difference in adduct formation was observed in liver between HBRN and WT mice.	dg-n2-bpde	28-38	prohibitin 2	Mus musculus	0-3
29181036-1	2017	Abdominal aortic aneurysm (AAA) is a fatal disease, and exposure to 3,4-benzopyrene (Bap) is closely related to the development of AAA.	Benzo(a)pyrene	68-83	prohibitin 2	Mus musculus	85-88
28500289-2	2017	Recent findings show that the brefeldin A-inhibited guanine nucleotide-exchange protein 3-prohibitin 2 (BIG3-PHB2) complex plays a crucial role in E2/ERalpha signalling modulation in breast cancer cells.	Brefeldin A	30-41	prohibitin 2	Mus musculus	109-113
26536361-9	2015	The involvement of PHBs in the FL3-mediated cardioprotection was confirmed by means of small interfering RNAs (siRNAs) targeting PHB1 and PHB2.	fl3	31-34	prohibitin 2	Mus musculus	138-142
26984301-7	2016	The BMD-covariate approach revealed tissue-specific differences in the induction of lacZ transgene mutations in Muta Mouse specimens exposed to benzo[a]pyrene (BaP), with the results permitting the formulation of mechanistic hypotheses regarding the observed potency ranking.	Benzo(a)pyrene	144-158	prohibitin 2	Mus musculus	160-163
23969104-3	2014	This two-vial formulation of PTX-loaded lipid nanoemulsion (TPLE) could significantly reduce extraction of reticuloendothelial system (RES) organs and increase tumor uptake, and exhibited more potent antitumor efficacy on bearing A2780 or Bcap-37 tumor nude mice compared to conventional PTX-loaded lipid nanoemulsion (CPLE).	Paclitaxel	29-32	prohibitin 2	Mus musculus	239-246
26481219-8	2015	This deep sequencing analysis of mutation spectrum demonstrated that BaP causes primarily guanine transversions (e.g. G:C   T:A), which is highly consistent with previous studies employing Sanger sequencing.	Guanine	90-97	prohibitin 2	Mus musculus	69-72
25308545-3	2014	The performance of a combined SCGE/Pig-a gene mutation study was evaluated with the prototypical genotoxicant benzo[a]pyrene (BaP) at an exposure level known to induce germ cell mutation.	Benzo(a)pyrene	110-124	prohibitin 2	Mus musculus	126-129
25308545-4	2014	We aimed to better understand (i) the strengths and weaknesses of the two methods applied in blood and their potential to predict germ cell mutagenicity, and (ii) the involvement of reactive oxygen species (ROS) following in vivo BaP-exposure.	Reactive Oxygen Species	182-205	prohibitin 2	Mus musculus	230-233
25308545-4	2014	We aimed to better understand (i) the strengths and weaknesses of the two methods applied in blood and their potential to predict germ cell mutagenicity, and (ii) the involvement of reactive oxygen species (ROS) following in vivo BaP-exposure.	Reactive Oxygen Species	207-210	prohibitin 2	Mus musculus	230-233
25308545-5	2014	To explore the involvement of ROS on BaP genotoxicity, we utilised a mouse model deficient in a DNA glycosylase.	Reactive Oxygen Species	30-33	prohibitin 2	Mus musculus	37-40
25769926-0	2015	Estradiol inhibits Th17 cell differentiation through inhibition of RORgammaT transcription by recruiting the ERalpha/REA complex to estrogen response elements of the RORgammaT promoter.	Estradiol	0-9	prohibitin 2	Mus musculus	117-120
25769926-11	2015	In 15 healthy premenopausal women, high serum estradiol levels are correlated with low RORgammaT mRNA levels and high REA mRNA levels in the vaginal lavage.	Estradiol	46-55	prohibitin 2	Mus musculus	118-121
25229620-16	2014	RESULTS: rhEndostatin reduced the growth of A549, QGY-7703, and Bcap37 xenograft tumors in a dose dependent manner.	rhendostatin	9-21	prohibitin 2	Mus musculus	64-70
24362092-5	2013	A 2.2- and 10.4-fold increase in amounts of ellipticine-derived DNA adducts formed by liver microsomes was caused by exposure of HRN and WT mice to BaP, respectively.	ellipticine	44-55	prohibitin 2	Mus musculus	148-151
25374376-1	2014	The present report was designed to determine the antigenotoxic capacity of beta-caryophyllene (BC) on the damage induced by benzo(a)pyrene (BaP) in mouse.	caryophyllene	75-93	prohibitin 2	Mus musculus	140-143
25374376-1	2014	The present report was designed to determine the antigenotoxic capacity of beta-caryophyllene (BC) on the damage induced by benzo(a)pyrene (BaP) in mouse.	caryophyllene	95-97	prohibitin 2	Mus musculus	140-143
25374376-1	2014	The present report was designed to determine the antigenotoxic capacity of beta-caryophyllene (BC) on the damage induced by benzo(a)pyrene (BaP) in mouse.	Benzo(a)pyrene	124-138	prohibitin 2	Mus musculus	140-143
25374376-6	2014	We found a dose-dependent decrease induced by BC in regard to both the oxidation of lipids and proteins produced by BaP.In the case of GST, when BC was administered alone we found a mean increase of 64% of the enzyme activity, respect to the control level, and when BC was administered in mice treated with BaP the increase obtained with the high dose of BC reached 27%.	caryophyllene	46-48	prohibitin 2	Mus musculus	116-119
25374376-6	2014	We found a dose-dependent decrease induced by BC in regard to both the oxidation of lipids and proteins produced by BaP.In the case of GST, when BC was administered alone we found a mean increase of 64% of the enzyme activity, respect to the control level, and when BC was administered in mice treated with BaP the increase obtained with the high dose of BC reached 27%.	caryophyllene	46-48	prohibitin 2	Mus musculus	307-310
25374376-6	2014	We found a dose-dependent decrease induced by BC in regard to both the oxidation of lipids and proteins produced by BaP.In the case of GST, when BC was administered alone we found a mean increase of 64% of the enzyme activity, respect to the control level, and when BC was administered in mice treated with BaP the increase obtained with the high dose of BC reached 27%.	caryophyllene	145-147	prohibitin 2	Mus musculus	116-119
25374376-6	2014	We found a dose-dependent decrease induced by BC in regard to both the oxidation of lipids and proteins produced by BaP.In the case of GST, when BC was administered alone we found a mean increase of 64% of the enzyme activity, respect to the control level, and when BC was administered in mice treated with BaP the increase obtained with the high dose of BC reached 27%.	caryophyllene	145-147	prohibitin 2	Mus musculus	307-310
25374376-6	2014	We found a dose-dependent decrease induced by BC in regard to both the oxidation of lipids and proteins produced by BaP.In the case of GST, when BC was administered alone we found a mean increase of 64% of the enzyme activity, respect to the control level, and when BC was administered in mice treated with BaP the increase obtained with the high dose of BC reached 27%.	caryophyllene	145-147	prohibitin 2	Mus musculus	116-119
25374376-6	2014	We found a dose-dependent decrease induced by BC in regard to both the oxidation of lipids and proteins produced by BaP.In the case of GST, when BC was administered alone we found a mean increase of 64% of the enzyme activity, respect to the control level, and when BC was administered in mice treated with BaP the increase obtained with the high dose of BC reached 27%.	caryophyllene	145-147	prohibitin 2	Mus musculus	307-310
25374376-6	2014	We found a dose-dependent decrease induced by BC in regard to both the oxidation of lipids and proteins produced by BaP.In the case of GST, when BC was administered alone we found a mean increase of 64% of the enzyme activity, respect to the control level, and when BC was administered in mice treated with BaP the increase obtained with the high dose of BC reached 27%.	caryophyllene	145-147	prohibitin 2	Mus musculus	116-119
25374376-6	2014	We found a dose-dependent decrease induced by BC in regard to both the oxidation of lipids and proteins produced by BaP.In the case of GST, when BC was administered alone we found a mean increase of 64% of the enzyme activity, respect to the control level, and when BC was administered in mice treated with BaP the increase obtained with the high dose of BC reached 27%.	caryophyllene	145-147	prohibitin 2	Mus musculus	307-310
23047765-1	2013	Benzo[a]pyrene (BaP) is a prototypical polycyclic aromatic hydrocarbon (PAH) found in combustion processes.	Benzo(a)pyrene	0-14	prohibitin 2	Mus musculus	16-19
23047765-1	2013	Benzo[a]pyrene (BaP) is a prototypical polycyclic aromatic hydrocarbon (PAH) found in combustion processes.	Polycyclic Aromatic Hydrocarbons	39-70	prohibitin 2	Mus musculus	16-19
23047765-1	2013	Benzo[a]pyrene (BaP) is a prototypical polycyclic aromatic hydrocarbon (PAH) found in combustion processes.	Polycyclic Aromatic Hydrocarbons	72-75	prohibitin 2	Mus musculus	16-19
23241883-3	2013	Using a proteomics-based identification approach, we show that the tyrosine-containing transmembrane adaptor proteins prohibitin (Phb)1 and Phb2 bind to CD86.	Tyrosine	67-75	prohibitin 2	Mus musculus	140-144
24362092-9	2013	Treatment of mice with BaP increases an impact of CYP1A on ellipticine activation.	ellipticine	59-70	prohibitin 2	Mus musculus	23-26
23909733-5	2013	Pretreatment of curcumin and curcumin plus piperine before administration of BaP significantly decreased the activities of EROD, PROD, and the level of BaPDE-DNA adducts with consequent increase in QR activities.	Curcumin	16-24	prohibitin 2	Mus musculus	77-80
23909733-5	2013	Pretreatment of curcumin and curcumin plus piperine before administration of BaP significantly decreased the activities of EROD, PROD, and the level of BaPDE-DNA adducts with consequent increase in QR activities.	Curcumin	29-37	prohibitin 2	Mus musculus	77-80
23909733-5	2013	Pretreatment of curcumin and curcumin plus piperine before administration of BaP significantly decreased the activities of EROD, PROD, and the level of BaPDE-DNA adducts with consequent increase in QR activities.	piperine	43-51	prohibitin 2	Mus musculus	77-80