PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
24528136-4	2014	Coadministration of an NMDA antagonist or 8-hydroxy-2-di-n-propylamino-tetralin [a serotonin (5-HT)1A,7 agonist, DPAT] with GRP limited c-fos expression in the SCN to a region dorsal to GRP cell bodies.	8-Hydroxy-2-(di-n-propylamino)tetralin	42-79	proto-oncogene c-Fos	Mesocricetus auratus	136-141
20704594-7	2010	In Experiment 2, we observed a similar pattern of decreased Fos expression, using fiber-sparing, NMDA lesions of the MEAa, suggesting that the decreases in Fos expression were not attributable exclusively to damage to passing fibers.	N-Methylaspartate	97-101	proto-oncogene c-Fos	Mesocricetus auratus	60-63
22580327-3	2012	In Leydig cells from reproductively active Syrian hamsters, Western blotting, reverse transcription quantitative polymerase chain reaction (RT-qPCR) and a colorimetric assay demonstrated that melatonin and CRH activate tyrosine phosphatases and subsequently reduce the phosphorylation levels of extracellular signal-regulated kinase (erk) and c-jun N-terminal kinase (jnk), down-regulate the expression of c-jun, c-fos and steroidogenic acute regulatory (StAR), and inhibit the production of testosterone.	Melatonin	192-201	proto-oncogene c-Fos	Mesocricetus auratus	413-418
20620195-6	2010	Approximately 36% of CTB-labeled cells within MeA (that project to MePD) also expressed Fos following exposure to either social odor, compared to the only 13% of CTB-labeled cells within MePD (that project to MeA) that also expressed odor-induced Fos.	ctb	21-24	proto-oncogene c-Fos	Mesocricetus auratus	88-91
18498439-4	2008	Injections of the 5-HT(1A/7) agonist +8-OH-DPAT or dark pulses at CT-6 induced phase-advances of the wheel-running activity rhythm and down-regulated the expression of the clock genes Per1-2 and c-FOS in the SCN in a similar way.	8-Hydroxy-2-(di-n-propylamino)tetralin	38-47	proto-oncogene c-Fos	Mesocricetus auratus	195-200
18279358-4	2008	c-FOS in hypocretin-1-immunoreactive neurons, in hypothalamic nonhypocretin neurons and in the IGL was significantly increased by novel wheel running, gentle handling and physical restraint, but only weakly by systemic injections of modafinil (300 mg/kg) or caffeine (75 mg/kg), at doses that are strongly alerting.	Modafinil	233-242	proto-oncogene c-Fos	Mesocricetus auratus	0-5
18279358-4	2008	c-FOS in hypocretin-1-immunoreactive neurons, in hypothalamic nonhypocretin neurons and in the IGL was significantly increased by novel wheel running, gentle handling and physical restraint, but only weakly by systemic injections of modafinil (300 mg/kg) or caffeine (75 mg/kg), at doses that are strongly alerting.	Caffeine	258-266	proto-oncogene c-Fos	Mesocricetus auratus	0-5
16157456-0	2006	ICV testosterone induces Fos in male Syrian hamster brain.	icv	0-3	proto-oncogene c-Fos	Mesocricetus auratus	25-28
16157456-0	2006	ICV testosterone induces Fos in male Syrian hamster brain.	Testosterone	4-16	proto-oncogene c-Fos	Mesocricetus auratus	25-28
16157456-11	2006	Testosterone infusion induced Fos above control in the posteromedial bed nucleus of the stria terminalis (BSTPM), posteromedial amygdala (MeP), lateral habenula (LHb), median raphe (MnR), lateral pontine nucleus (Pn), and ventral tegmental area (VTA).	Testosterone	0-12	proto-oncogene c-Fos	Mesocricetus auratus	30-33
16157456-12	2006	In particular, Fos was elevated in the BSTPM, MeP, LHb, and VTA only after 1 day of testosterone.	5-[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-Aminopurin-9-Yl)-3,4-Bis(Oxidanyl)oxolan-2-Yl]methylamino]methyl]-4-Azanyl-1-(Methoxymethyl)pyrimidin-2-One	51-54	proto-oncogene c-Fos	Mesocricetus auratus	15-18
16157456-12	2006	In particular, Fos was elevated in the BSTPM, MeP, LHb, and VTA only after 1 day of testosterone.	Testosterone	84-96	proto-oncogene c-Fos	Mesocricetus auratus	15-18
16157456-13	2006	15 days of testosterone enhanced Fos expression above control in the MnR and lateral Pn.	Testosterone	11-23	proto-oncogene c-Fos	Mesocricetus auratus	33-36
10230709-2	1999	These cues may act through dopaminergic activation of the fetal suprachiasmatic nucleus (SCN); injection of the dopamine D1 agonist SKF38393 to pregnant hamsters entrains activity rhythms of their pups and induces expression of c-fos in the fetal SCN.	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	132-140	proto-oncogene c-Fos	Mesocricetus auratus	228-233
11516834-6	2001	Destruction of the receptors in the main olfactory system with zinc sulfate eliminated the increase in fos immunoreactivity in the amygdala, bed nucleus of the stria terminalis and preoptic area following exposure to sexually stimulating pheromones.	Zinc Sulfate	63-75	proto-oncogene c-Fos	Mesocricetus auratus	103-106
10444312-6	1999	In particular, c-fos mRNA levels were significantly decreased within the paraventricular nucleus of the hypothalamus (PVN), supraoptic nucleus of the hypothalamus, septohypothalamic nucleus, intermediate subdivision of the lateral septum, central amygdaloid nucleus, and the amygdalohippocampal area in the CD group exposed to an acute challenge when compared to males defeated only once.	Cadmium	307-309	proto-oncogene c-Fos	Mesocricetus auratus	15-20
10444312-9	1999	We discuss the possibility that decreased expression of c-fos mRNA within the PVN and other brain regions of defeated animals-in the presence of elevated adrenal steroids-may reflect a state of molecular plasticity that could alter neurotransmission within the limbic-hypothalamo-pituitary-adrenocortical axis.	Steroids	162-170	proto-oncogene c-Fos	Mesocricetus auratus	56-61
10320727-4	1999	We showed a lower number of Fos-ir cells in the SCN of IGLx hamsters following a light pulse applied 13 h after dark onset, 25 nights after the transfer from LP to SP compared to sham operated hamsters.	TFF2 protein, human	164-166	proto-oncogene c-Fos	Mesocricetus auratus	28-31
9918228-0	1999	Glutamatergic induction of CREB phosphorylation and Fos expression in primary cultures of the suprachiasmatic hypothalamus in vitro is mediated by co-ordinate activity of NMDA and non-NMDA receptors.	N-Methylaspartate	171-175	proto-oncogene c-Fos	Mesocricetus auratus	52-55
9918228-2	1999	Light also induced nuclear Fos-ir in the same region of the SCN after 1 h. The glutamatergic N-methyl-D-aspartate (NMDA) receptor blocker MK801 attenuated the photic induction of both factors.	Dizocilpine Maleate	138-143	proto-oncogene c-Fos	Mesocricetus auratus	27-30
9918228-5	1999	Glutamate or the mixture of agonists also induced a 56 kDa band identified as Fos protein in SCN tissue.	Glutamic Acid	0-9	proto-oncogene c-Fos	Mesocricetus auratus	78-81
9918228-6	1999	In dissociated cultures of SCN, glutamate caused a rapid (15 min) induction of nuclear pCREB-ir and Fos-ir (after 60 min) exclusively in neurones, both GABA-ir and others.	Glutamic Acid	32-41	proto-oncogene c-Fos	Mesocricetus auratus	100-103
9918228-10	1999	The effects of glutamate on pCREB-ir and Fos-ir were blocked by antagonists of both NMDA (MK801) and AMPA/KA (NBQX) receptors.	Glutamic Acid	15-24	proto-oncogene c-Fos	Mesocricetus auratus	41-44
9918228-10	1999	The effects of glutamate on pCREB-ir and Fos-ir were blocked by antagonists of both NMDA (MK801) and AMPA/KA (NBQX) receptors.	N-Methylaspartate	84-88	proto-oncogene c-Fos	Mesocricetus auratus	41-44
9918228-10	1999	The effects of glutamate on pCREB-ir and Fos-ir were blocked by antagonists of both NMDA (MK801) and AMPA/KA (NBQX) receptors.	Dizocilpine Maleate	90-95	proto-oncogene c-Fos	Mesocricetus auratus	41-44
9918228-11	1999	In the absence of extracellular Mg2+, MK801 blocked glutamatergic induction of Fos-ir.	Dizocilpine Maleate	38-43	proto-oncogene c-Fos	Mesocricetus auratus	79-82
9918228-12	1999	However, the AMPA/KA receptor antagonist was no longer effective at blocking glutamatergic induction of either Fos-ir or pCREB-ir, consistent with the model that glutamate regulates gene expression in the SCN by a co-ordinate action through both NMDA and AMPA/KA receptors.	Glutamic Acid	77-86	proto-oncogene c-Fos	Mesocricetus auratus	111-114
9744484-0	1998	Effect of NMDA receptor antagonist MK-801 on light-induced Fos expression in the suprachiasmatic nuclei and on melatonin production in the Syrian hamster.	Dizocilpine Maleate	35-41	proto-oncogene c-Fos	Mesocricetus auratus	59-62
9744484-7	1998	According to previous studies, MK-801 inhibits light-induced Fos immunoreactivity mainly in the most ventral part of the SCN.	Dizocilpine Maleate	31-37	proto-oncogene c-Fos	Mesocricetus auratus	61-64
9106997-5	1997	Both c-fos mRNA and Fos protein were expressed in the fetal SCN after SKF 38393 injection but neither were expressed after melatonin injection.	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	70-79	proto-oncogene c-Fos	Mesocricetus auratus	5-10
9735225-4	1998	Fos-ir was increased within the caudal posterodorsal Me (cMePD), the anterodorsal and posteroventral subdivisions of the posteromedial BNST [BNSTpm(ad) and BNSTpm(pv)], the dorsolateral MPOA, and the medial preoptic nucleus of all males mated to sexual satiety compared to nonmated controls.	methionylglutamic acid	53-55	proto-oncogene c-Fos	Mesocricetus auratus	0-3
9106997-5	1997	Both c-fos mRNA and Fos protein were expressed in the fetal SCN after SKF 38393 injection but neither were expressed after melatonin injection.	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	70-79	proto-oncogene c-Fos	Mesocricetus auratus	20-23
9047271-0	1996	Testosterone differentially influences sex-specific pheromone-stimulated Fos expression in limbic regions of Syrian hamsters.	Testosterone	0-12	proto-oncogene c-Fos	Mesocricetus auratus	73-76
9182863-1	1997	The chronic administration of 17beta-estradiol to male Syrian hamsters for 6-7 months induces kidney tumors which express high levels of c-fos, c-myc and c-jun mRNA compared to surrounding tissue or untreated controls.	Estradiol	30-46	proto-oncogene c-Fos	Mesocricetus auratus	137-142
8794894-5	1996	The dose-dependent effect of OA on 3-MC-induced CYP2A8 expression corresponded to that of OA on c-fos and jun-D mRNA induction and on the activation of AP-1-dependent gene transcription.	Methylcholanthrene	35-39	proto-oncogene c-Fos	Mesocricetus auratus	96-101
8794894-6	1996	The expression of c-fos and jun-D mRNA induced by OA preceded the expression of CYP2A8 mRNA potentiated by co-treatment with 3-MC and OA.	Methylcholanthrene	125-129	proto-oncogene c-Fos	Mesocricetus auratus	18-23
8794894-7	1996	Treatment with anisomycin and cycloheximide also potentiated 0.1 microM 3-MC-induced coumarin 7-hydroxylase activity, induced c-fos and jun-D mRNA expression, and activated AP-1-dependent gene transcription in the hepatocytes.	Anisomycin	15-25	proto-oncogene c-Fos	Mesocricetus auratus	126-131
8794894-7	1996	Treatment with anisomycin and cycloheximide also potentiated 0.1 microM 3-MC-induced coumarin 7-hydroxylase activity, induced c-fos and jun-D mRNA expression, and activated AP-1-dependent gene transcription in the hepatocytes.	Cycloheximide	30-43	proto-oncogene c-Fos	Mesocricetus auratus	126-131
8794894-7	1996	Treatment with anisomycin and cycloheximide also potentiated 0.1 microM 3-MC-induced coumarin 7-hydroxylase activity, induced c-fos and jun-D mRNA expression, and activated AP-1-dependent gene transcription in the hepatocytes.	Methylcholanthrene	72-76	proto-oncogene c-Fos	Mesocricetus auratus	126-131
7902183-3	1993	injection of the serotonergic, quipazine, caused a marked decrease in the number of SCN cells expressing Fos protein-like immunoreactivity (Fos-LI) induced by a light pulse delivered during the latter part of the dark phase (7 h after lights-off; 55.6 +/- 7.5% of vehicle controls, P < 0.004).	Quipazine	31-40	proto-oncogene c-Fos	Mesocricetus auratus	105-108
8726998-4	1996	The purpose of the present study was to investigate the neural circuit controlling flank marking by localizing the induction of Fos protein in response to the microinjection of AVP, a V1a-AVP antagonist (AVPA) or saline into the MPOA-AH.	Sodium Chloride	213-219	proto-oncogene c-Fos	Mesocricetus auratus	128-131
8726998-7	1996	The number of Fos-positive neurons was significantly greater in the BNST, PAG, and central amygdala (Ce) following the microinjection of AVP than following the microinjection of either AVPA or saline.	UNII-FFM269698K	185-189	proto-oncogene c-Fos	Mesocricetus auratus	14-17
8726998-7	1996	The number of Fos-positive neurons was significantly greater in the BNST, PAG, and central amygdala (Ce) following the microinjection of AVP than following the microinjection of either AVPA or saline.	Sodium Chloride	193-199	proto-oncogene c-Fos	Mesocricetus auratus	14-17
7539271-3	1995	The results revealed that when ionizing radiation (either fission-spectrum neutrons or gamma rays) was administered 15 min after cycloheximide treatment of SHE cells, the radiation exposure reduced cycloheximide-mediated gene induction of c-fos, histone H4, and c-jun.	Cycloheximide	198-211	proto-oncogene c-Fos	Mesocricetus auratus	239-244
8680432-13	1993	NMDA induced widespread expression of c-fos in many periventricular regions including the medial preoptic area (POA) and ventromedial hypothalamic nucleus.	N-Methylaspartate	0-4	proto-oncogene c-Fos	Mesocricetus auratus	38-43
8581468-11	1995	FOS-li was increased in the AP/NTS only in hamsters food deprived or treated with 2DG, the two treatments that induce anestrus but have no effect on food intake.	Deoxyglucose	82-85	proto-oncogene c-Fos	Mesocricetus auratus	0-3
21552870-1	1995	Chronic administration of 17 beta-estradiol to male Syrian hamsters for at least six months induces estrogen-dependent kidney tumors, which express high levels of c-fos mRNA compared to surrounding renal or control tissues.	Estradiol	26-43	proto-oncogene c-Fos	Mesocricetus auratus	163-168
21552870-9	1995	In H-301 cells, c-fos levels were increased four-fold over controls after 3 h of 17 beta-estradiol treatment and this induction was suppressed by antiestrogen treatment.	Estradiol	84-98	proto-oncogene c-Fos	Mesocricetus auratus	16-21
21552870-10	1995	In hamster kidneys, c-fos levels were increased about two-fold by 17 beta-estradiol, but this induction was not affected by antiestrogen treatment.	Estradiol	66-83	proto-oncogene c-Fos	Mesocricetus auratus	20-25
21552870-11	1995	In H-301 cells but not in hamster kidneys, 17 alpha-ethinylestradiol induced c-fos.	alpha-ethinylestradiol	46-68	proto-oncogene c-Fos	Mesocricetus auratus	77-82
21552870-12	1995	17 alpha-estradiol was more potent than 17 beta-estradiol in the induction of c-fos in hamster kidney but was a poor inducer in H-301 cells.	alfatradiol	0-18	proto-oncogene c-Fos	Mesocricetus auratus	78-83
21552870-12	1995	17 alpha-estradiol was more potent than 17 beta-estradiol in the induction of c-fos in hamster kidney but was a poor inducer in H-301 cells.	Estradiol	40-57	proto-oncogene c-Fos	Mesocricetus auratus	78-83
7902183-3	1993	injection of the serotonergic, quipazine, caused a marked decrease in the number of SCN cells expressing Fos protein-like immunoreactivity (Fos-LI) induced by a light pulse delivered during the latter part of the dark phase (7 h after lights-off; 55.6 +/- 7.5% of vehicle controls, P < 0.004).	Quipazine	31-40	proto-oncogene c-Fos	Mesocricetus auratus	140-143
7902183-5	1993	In a likewise manner, intra-SCN microinjection of quipazine inhibited light-induced Fos-LI in the ventrolateral SCN, indicating that the suppressive action of quipazine is centered in the SCN.	Quipazine	50-59	proto-oncogene c-Fos	Mesocricetus auratus	84-87
8448651-4	1993	Tz-induced Fos-labeled nuclei were found in superior colliculi, Edinger-Westphal nuclei (EW) and dorsal tegmental nuclei (DTg), but not in the RN.	Triazolam	0-2	proto-oncogene c-Fos	Mesocricetus auratus	11-14
8364719-0	1993	A cholinergic antagonist, mecamylamine, blocks light-induced fos immunoreactivity in specific regions of the hamster suprachiasmatic nucleus.	Mecamylamine	26-38	proto-oncogene c-Fos	Mesocricetus auratus	61-64
8364719-2	1993	In order to explore further the importance of c-fos expression for the phase-shifting effects of light, we examined the effects of mecamylamine on light-induced Fos-like immunoreactivity (Fos-lir) in the SCN.	Mecamylamine	131-143	proto-oncogene c-Fos	Mesocricetus auratus	161-164
8364719-9	1993	Mecamylamine pretreatment dramatically reduced light-induced Fos-lir in the SCN by 75%.	Mecamylamine	0-12	proto-oncogene c-Fos	Mesocricetus auratus	61-64
8364719-10	1993	The most striking observation was the clear inhibition of Fos-lir by mecamylamine in the dorsomedial region of the SCN while there was little inhibition of Fos-lir in the most ventral portions of the SCN.	Mecamylamine	69-81	proto-oncogene c-Fos	Mesocricetus auratus	58-61
8348332-1	1993	Fos-immunoreactivity is induced during mating in the male Syrian hamster in limbic areas that relay chemosensory information and contain receptors for gonadal steroid hormones.	Steroids	159-175	proto-oncogene c-Fos	Mesocricetus auratus	0-3
8448651-4	1993	Tz-induced Fos-labeled nuclei were found in superior colliculi, Edinger-Westphal nuclei (EW) and dorsal tegmental nuclei (DTg), but not in the RN.	1-(4-azido-2-methylphenyl)-3-(2-methylphenyl)guanidine	122-125	proto-oncogene c-Fos	Mesocricetus auratus	11-14
19215534-13	1991	To determine whether NMDA had the potential to activate c-fos expression in the SCN, hamsters were infused with 2.5 nmol NMDA or vehicle via an intracerebroventricular (icv) cannula positioned adjacent to the nuclei.	N-Methylaspartate	21-25	proto-oncogene c-Fos	Mesocricetus auratus	56-61
12106331-9	1992	However, when the light pulse was preceded by icv fusion of DGG at a dose which would block the phase-shifting response to light, the total number of neurons immunopositive for Fos was significantly reduced ( approximately 50%) and the expression was confined to a restricted area of the dorsolateral SCN.	dgg	60-63	proto-oncogene c-Fos	Mesocricetus auratus	177-180
8274763-4	1993	Microinjection of excitatory amino acid (EAA) antagonists into the region of the SCN attenuates light-induced phase advances of the free-running activity rhythm and light-induced Fos expression in the hamster SCN.	Excitatory Amino Acids	18-39	proto-oncogene c-Fos	Mesocricetus auratus	179-182
8274763-4	1993	Microinjection of excitatory amino acid (EAA) antagonists into the region of the SCN attenuates light-induced phase advances of the free-running activity rhythm and light-induced Fos expression in the hamster SCN.	Excitatory Amino Acids	41-44	proto-oncogene c-Fos	Mesocricetus auratus	179-182
8274763-5	1993	However, injection of N-methyl-D-aspartate (NMDA) at CT 18, which results in a widespread pattern of Fos expression in the hypothalamus that includes the retinorecipient zone of the SCN, does not produce phase advances of the circadian oscillator.	N-Methylaspartate	22-42	proto-oncogene c-Fos	Mesocricetus auratus	101-104
8274763-5	1993	However, injection of N-methyl-D-aspartate (NMDA) at CT 18, which results in a widespread pattern of Fos expression in the hypothalamus that includes the retinorecipient zone of the SCN, does not produce phase advances of the circadian oscillator.	N-Methylaspartate	44-48	proto-oncogene c-Fos	Mesocricetus auratus	101-104
8274763-7	1993	However, expression of Fos in the SCN induced by the EAA agonist NMDA is not sufficient to cause phase advances of the SCN oscillator.	N-Methylaspartate	65-69	proto-oncogene c-Fos	Mesocricetus auratus	23-26
1576713-5	1992	mRNA levels of fos, myc and jun were elevated 15-, 4- and 6-fold respectively in kidney tumors of estradiol-treated hamsters (9 months) compared with age-matched untreated control kidneys.	Estradiol	98-107	proto-oncogene c-Fos	Mesocricetus auratus	15-18
1576713-11	1992	Overexpression of cellular oncogenes such as c-fos, c-jun and c-myc may have played a role in the induction and growth of kidney tumors by estradiol in hamsters.	Estradiol	139-148	proto-oncogene c-Fos	Mesocricetus auratus	47-50
19215534-14	1991	In contrast to the effects of light, icv NMDA activated c-fos expression at both CT8 and CT 14.	N-Methylaspartate	41-45	proto-oncogene c-Fos	Mesocricetus auratus	56-61
19215534-18	1991	MK801 (10 or 100 nmol) delivered centrally (icv) also prevented light-induced c-fos expression in the ventral region of the SCN bordering the optic chiasm, though staining again persisted in the dorsolateral region.	Dizocilpine Maleate	0-5	proto-oncogene c-Fos	Mesocricetus auratus	78-83
19215534-19	1991	The induction of c-fos by icv NMDA, and the partial blockade of light-induced c-fos expression by the antagonist MK801, are consistent with the hypothesis that glutamate mediates the effects of light on SCN activity.	N-Methylaspartate	30-34	proto-oncogene c-Fos	Mesocricetus auratus	17-22
19215534-19	1991	The induction of c-fos by icv NMDA, and the partial blockade of light-induced c-fos expression by the antagonist MK801, are consistent with the hypothesis that glutamate mediates the effects of light on SCN activity.	Dizocilpine Maleate	113-118	proto-oncogene c-Fos	Mesocricetus auratus	78-83
19215534-19	1991	The induction of c-fos by icv NMDA, and the partial blockade of light-induced c-fos expression by the antagonist MK801, are consistent with the hypothesis that glutamate mediates the effects of light on SCN activity.	Glutamic Acid	160-169	proto-oncogene c-Fos	Mesocricetus auratus	78-83
19215534-20	1991	However, the persistent photic induction of c-fos expression in a subfield of retinal afferents following treatment with MK801 suggests that other, non-NMDA-type mechanisms may contribute to photic entrainment.	Dizocilpine Maleate	121-126	proto-oncogene c-Fos	Mesocricetus auratus	44-49
29183829-4	2018	Chronic administration of both paroxetine and alprazolam decreased these responses with morphological correlates between the panicolytic effect of both drugs administered at the highest dose and decreases in Fos protein-immunolabeled perikarya found in the amygdaloid complex, hypothalamus and periaqueductal gray matter columns, which are structures that make up the encephalic aversion system.	Paroxetine	31-41	proto-oncogene c-Fos	Mesocricetus auratus	208-211
29183829-4	2018	Chronic administration of both paroxetine and alprazolam decreased these responses with morphological correlates between the panicolytic effect of both drugs administered at the highest dose and decreases in Fos protein-immunolabeled perikarya found in the amygdaloid complex, hypothalamus and periaqueductal gray matter columns, which are structures that make up the encephalic aversion system.	Alprazolam	46-56	proto-oncogene c-Fos	Mesocricetus auratus	208-211