PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
29535328-0	2018	Use of quercetin in animal feed: effects on the P-gp expression and pharmacokinetics of orally administrated enrofloxacin in chicken.	Quercetin	7-16	phosphoglycolate phosphatase	Gallus gallus	48-52
29535328-2	2018	Quercetin has a potential to modulate P-gp in rodents, however, its effects on P-gp modulation in chicken are still unclear.	Quercetin	0-9	phosphoglycolate phosphatase	Gallus gallus	38-42
29535328-2	2018	Quercetin has a potential to modulate P-gp in rodents, however, its effects on P-gp modulation in chicken are still unclear.	Quercetin	0-9	phosphoglycolate phosphatase	Gallus gallus	79-83
29535328-3	2018	Herein, study reports role of quercetin in modulation of P-gp expression and subsequent effects on the pharmacokinetics of enrofloxacin in broilers.	Quercetin	30-39	phosphoglycolate phosphatase	Gallus gallus	57-61
29535328-3	2018	Herein, study reports role of quercetin in modulation of P-gp expression and subsequent effects on the pharmacokinetics of enrofloxacin in broilers.	Enrofloxacin	123-135	phosphoglycolate phosphatase	Gallus gallus	57-61
29535328-5	2018	Absorption rate constant and apparent permeability coefficient of rhodamine 123 were decreased, reflecting efflux function of P-gp in chicken intestine increased by quercetin.	Rhodamine 123	66-79	phosphoglycolate phosphatase	Gallus gallus	126-130
29535328-5	2018	Absorption rate constant and apparent permeability coefficient of rhodamine 123 were decreased, reflecting efflux function of P-gp in chicken intestine increased by quercetin.	Quercetin	165-174	phosphoglycolate phosphatase	Gallus gallus	126-130
29535328-8	2018	Results provide convincing evidence that quercetin induced P-gp expression in tissues by possible interaction with CXR, and consequently reducing bioavailability of orally administered enrofloxacin through restricting its intestinal absorption and liver/kidney clearance in broilers.	Quercetin	41-50	phosphoglycolate phosphatase	Gallus gallus	59-63
17188652-6	2007	P-gp inhibitors, PSC833 and GF120918, significantly inhibit Rh-123 efflux, whereas inhibitors for MRPs and BCRP, MK571 and Ko-143, respectively, have a limited inhibitory effect.	Elacridar	28-36	phosphoglycolate phosphatase	Gallus gallus	0-4
29805456-0	2018	The roles of cytochrome P450 and P-glycoprotein in the pharmacokinetics of florfenicol in chickens.	florfenicol	75-86	phosphoglycolate phosphatase	Gallus gallus	33-47
27234533-6	2016	The efflux ratio of rhodamine123 (Rho123, a human P-gp substrate) in chAbcb1 transfected MDCK cells was significantly higher than that in the wild type MDCK cell (6.24 vs 1.64, P<0.05), suggesting a good transporting function of chicken P-gp overexpressed in the transfected cell.	Rhodamine 123	20-32	phosphoglycolate phosphatase	Gallus gallus	240-244
23758033-7	2013	After treatment of the animals with sulfapyrazine for three days, not only a significant improvement of the clinical appearance but also a normalization of the P-gp expression was noticed.	SULFAPYRAZINE	36-49	phosphoglycolate phosphatase	Gallus gallus	160-164
17188652-6	2007	P-gp inhibitors, PSC833 and GF120918, significantly inhibit Rh-123 efflux, whereas inhibitors for MRPs and BCRP, MK571 and Ko-143, respectively, have a limited inhibitory effect.	Rhodium	60-62	phosphoglycolate phosphatase	Gallus gallus	0-4
17188652-6	2007	P-gp inhibitors, PSC833 and GF120918, significantly inhibit Rh-123 efflux, whereas inhibitors for MRPs and BCRP, MK571 and Ko-143, respectively, have a limited inhibitory effect.	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester	123-129	phosphoglycolate phosphatase	Gallus gallus	0-4
33248620-0	2020	Curcumin ameliorates duodenal toxicity of AFB1 in chicken through inducing P-glycoprotein and downregulating cytochrome P450 enzymes.	Curcumin	0-8	phosphoglycolate phosphatase	Gallus gallus	75-89
33248620-9	2020	Furthermore, curcumin ameliorated AFB1-induced decrease in the Abcb1 mRNA expression, P-glycoprotein (P-gp) level, and ATPase activities.	Curcumin	13-21	phosphoglycolate phosphatase	Gallus gallus	86-100
31013627-0	2019	Inhibitory Effect of Berberine on Broiler P-glycoprotein Expression and Function: In Situ and In Vitro Studies.	Berberine	21-30	phosphoglycolate phosphatase	Gallus gallus	42-56
33248620-9	2020	Furthermore, curcumin ameliorated AFB1-induced decrease in the Abcb1 mRNA expression, P-glycoprotein (P-gp) level, and ATPase activities.	Curcumin	13-21	phosphoglycolate phosphatase	Gallus gallus	102-106
33248620-10	2020	It has been suggested from these results that curcumin supplementation in the feed could ameliorate AFB1-induced duodenal toxicity and damage through downregulating CYP450 enzymes, promoting ATPase activities, and inducing P-gp in chickens.	Curcumin	46-54	phosphoglycolate phosphatase	Gallus gallus	223-227
33248620-10	2020	It has been suggested from these results that curcumin supplementation in the feed could ameliorate AFB1-induced duodenal toxicity and damage through downregulating CYP450 enzymes, promoting ATPase activities, and inducing P-gp in chickens.	Aflatoxin B1	100-104	phosphoglycolate phosphatase	Gallus gallus	223-227
31013627-2	2019	Berberine inhibits P-gp and thereby increases the bioavailability of the P-gp substrate digoxin in rodents.	Berberine	0-9	phosphoglycolate phosphatase	Gallus gallus	19-23
31013627-2	2019	Berberine inhibits P-gp and thereby increases the bioavailability of the P-gp substrate digoxin in rodents.	Berberine	0-9	phosphoglycolate phosphatase	Gallus gallus	73-77
31013627-2	2019	Berberine inhibits P-gp and thereby increases the bioavailability of the P-gp substrate digoxin in rodents.	Digoxin	88-95	phosphoglycolate phosphatase	Gallus gallus	19-23
31013627-2	2019	Berberine inhibits P-gp and thereby increases the bioavailability of the P-gp substrate digoxin in rodents.	Digoxin	88-95	phosphoglycolate phosphatase	Gallus gallus	73-77
31013627-4	2019	Here, we studied the role of berberine in modulating broilers P-gp expression and function through both in situ and in vitro models.	Berberine	29-38	phosphoglycolate phosphatase	Gallus gallus	62-66
31013627-5	2019	In addition, molecular docking was applied to analyze the interactions of berberine with P-gp as well as with chicken xenobiotic receptor (CXR).	Berberine	74-83	phosphoglycolate phosphatase	Gallus gallus	89-93
31013627-6	2019	The results showed that the mRNA expression levels of chicken P-gp and CXR decreased in the ileum following exposure to berberine.	Berberine	120-129	phosphoglycolate phosphatase	Gallus gallus	62-66
31013627-8	2019	Efflux ratios of P-gp substrates (tilmicosin, ciprofloxacin, clindamycin, ampicillin, and enrofloxacin) decreased and the apparent permeability coefficients increased after co-incubation with berberine in MDCK-chAbcb1 cell models.	tilmicosin	34-44	phosphoglycolate phosphatase	Gallus gallus	17-21
31013627-8	2019	Efflux ratios of P-gp substrates (tilmicosin, ciprofloxacin, clindamycin, ampicillin, and enrofloxacin) decreased and the apparent permeability coefficients increased after co-incubation with berberine in MDCK-chAbcb1 cell models.	Ciprofloxacin	46-59	phosphoglycolate phosphatase	Gallus gallus	17-21
31013627-8	2019	Efflux ratios of P-gp substrates (tilmicosin, ciprofloxacin, clindamycin, ampicillin, and enrofloxacin) decreased and the apparent permeability coefficients increased after co-incubation with berberine in MDCK-chAbcb1 cell models.	Clindamycin	61-72	phosphoglycolate phosphatase	Gallus gallus	17-21
31013627-8	2019	Efflux ratios of P-gp substrates (tilmicosin, ciprofloxacin, clindamycin, ampicillin, and enrofloxacin) decreased and the apparent permeability coefficients increased after co-incubation with berberine in MDCK-chAbcb1 cell models.	Ampicillin	74-84	phosphoglycolate phosphatase	Gallus gallus	17-21
31013627-8	2019	Efflux ratios of P-gp substrates (tilmicosin, ciprofloxacin, clindamycin, ampicillin, and enrofloxacin) decreased and the apparent permeability coefficients increased after co-incubation with berberine in MDCK-chAbcb1 cell models.	Enrofloxacin	90-102	phosphoglycolate phosphatase	Gallus gallus	17-21
31013627-8	2019	Efflux ratios of P-gp substrates (tilmicosin, ciprofloxacin, clindamycin, ampicillin, and enrofloxacin) decreased and the apparent permeability coefficients increased after co-incubation with berberine in MDCK-chAbcb1 cell models.	Berberine	192-201	phosphoglycolate phosphatase	Gallus gallus	17-21
31013627-9	2019	Bidirectional assay results showed that berberine could be transported by chicken P-gp with a transport ratio of 4.20, and this was attenuated by verapamil (an inhibitor of P-gp), which resulted in a ratio of 1.13.	Berberine	40-49	phosphoglycolate phosphatase	Gallus gallus	82-86
31013627-9	2019	Bidirectional assay results showed that berberine could be transported by chicken P-gp with a transport ratio of 4.20, and this was attenuated by verapamil (an inhibitor of P-gp), which resulted in a ratio of 1.13.	Berberine	40-49	phosphoglycolate phosphatase	Gallus gallus	173-177
31013627-9	2019	Bidirectional assay results showed that berberine could be transported by chicken P-gp with a transport ratio of 4.20, and this was attenuated by verapamil (an inhibitor of P-gp), which resulted in a ratio of 1.13.	Verapamil	146-155	phosphoglycolate phosphatase	Gallus gallus	173-177
31013627-10	2019	Molecular docking revealed that berberine could form favorable interactions with the binding pockets of both CXR and P-gp, with docking scores of -7.8 and -9.5 kcal/mol, respectively.	Berberine	32-41	phosphoglycolate phosphatase	Gallus gallus	117-121
31013627-11	2019	These results indicate that berberine is a substrate of chicken P-gp and down-regulates P-gp expression in chicken tissues, thereby increasing the absorption of P-gp substrates.	Berberine	28-37	phosphoglycolate phosphatase	Gallus gallus	64-68
31013627-11	2019	These results indicate that berberine is a substrate of chicken P-gp and down-regulates P-gp expression in chicken tissues, thereby increasing the absorption of P-gp substrates.	Berberine	28-37	phosphoglycolate phosphatase	Gallus gallus	88-92
31013627-11	2019	These results indicate that berberine is a substrate of chicken P-gp and down-regulates P-gp expression in chicken tissues, thereby increasing the absorption of P-gp substrates.	Berberine	28-37	phosphoglycolate phosphatase	Gallus gallus	88-92
31013627-12	2019	Our findings suggest that berberine increases the bioavailability of other drugs and that drug-drug interactions should be considered when it is co-administered with other P-gp substrates with narrow therapeutic windows.	Berberine	26-35	phosphoglycolate phosphatase	Gallus gallus	172-176
29725709-5	2018	Enrofloxacin, ciprofloxacin, tilmicosin, sulfadiazine, ampicillin and clindamycin were classified as the substrates of chicken P-gp according to the rules suggested by FDA, as their net efflux ratios were greater than two.	Enrofloxacin	0-12	phosphoglycolate phosphatase	Gallus gallus	127-131
29725709-7	2018	Among these drugs, enrofloxacin, ciprofloxacin, tilmicosin, ampicillin, and clindamycin were the cosubstrates of P-gp and BCRP, however, chicken BCRP and P-gp exhibit different affinities to the shared substrates at different concentrations by blocking either one or both transport with specific inhibitors in the coexpression system.	Ampicillin	60-70	phosphoglycolate phosphatase	Gallus gallus	154-158
29725709-7	2018	Among these drugs, enrofloxacin, ciprofloxacin, tilmicosin, ampicillin, and clindamycin were the cosubstrates of P-gp and BCRP, however, chicken BCRP and P-gp exhibit different affinities to the shared substrates at different concentrations by blocking either one or both transport with specific inhibitors in the coexpression system.	Clindamycin	76-87	phosphoglycolate phosphatase	Gallus gallus	113-117
29725709-5	2018	Enrofloxacin, ciprofloxacin, tilmicosin, sulfadiazine, ampicillin and clindamycin were classified as the substrates of chicken P-gp according to the rules suggested by FDA, as their net efflux ratios were greater than two.	Ciprofloxacin	14-27	phosphoglycolate phosphatase	Gallus gallus	127-131
29725709-7	2018	Among these drugs, enrofloxacin, ciprofloxacin, tilmicosin, ampicillin, and clindamycin were the cosubstrates of P-gp and BCRP, however, chicken BCRP and P-gp exhibit different affinities to the shared substrates at different concentrations by blocking either one or both transport with specific inhibitors in the coexpression system.	Clindamycin	76-87	phosphoglycolate phosphatase	Gallus gallus	154-158
29725709-5	2018	Enrofloxacin, ciprofloxacin, tilmicosin, sulfadiazine, ampicillin and clindamycin were classified as the substrates of chicken P-gp according to the rules suggested by FDA, as their net efflux ratios were greater than two.	tilmicosin	29-39	phosphoglycolate phosphatase	Gallus gallus	127-131
29725709-5	2018	Enrofloxacin, ciprofloxacin, tilmicosin, sulfadiazine, ampicillin and clindamycin were classified as the substrates of chicken P-gp according to the rules suggested by FDA, as their net efflux ratios were greater than two.	Sulfadiazine	41-53	phosphoglycolate phosphatase	Gallus gallus	127-131
29725709-5	2018	Enrofloxacin, ciprofloxacin, tilmicosin, sulfadiazine, ampicillin and clindamycin were classified as the substrates of chicken P-gp according to the rules suggested by FDA, as their net efflux ratios were greater than two.	Ampicillin	55-65	phosphoglycolate phosphatase	Gallus gallus	127-131
29725709-5	2018	Enrofloxacin, ciprofloxacin, tilmicosin, sulfadiazine, ampicillin and clindamycin were classified as the substrates of chicken P-gp according to the rules suggested by FDA, as their net efflux ratios were greater than two.	Clindamycin	70-81	phosphoglycolate phosphatase	Gallus gallus	127-131
29725709-7	2018	Among these drugs, enrofloxacin, ciprofloxacin, tilmicosin, ampicillin, and clindamycin were the cosubstrates of P-gp and BCRP, however, chicken BCRP and P-gp exhibit different affinities to the shared substrates at different concentrations by blocking either one or both transport with specific inhibitors in the coexpression system.	Enrofloxacin	19-31	phosphoglycolate phosphatase	Gallus gallus	113-117
29725709-7	2018	Among these drugs, enrofloxacin, ciprofloxacin, tilmicosin, ampicillin, and clindamycin were the cosubstrates of P-gp and BCRP, however, chicken BCRP and P-gp exhibit different affinities to the shared substrates at different concentrations by blocking either one or both transport with specific inhibitors in the coexpression system.	Enrofloxacin	19-31	phosphoglycolate phosphatase	Gallus gallus	154-158
29725709-7	2018	Among these drugs, enrofloxacin, ciprofloxacin, tilmicosin, ampicillin, and clindamycin were the cosubstrates of P-gp and BCRP, however, chicken BCRP and P-gp exhibit different affinities to the shared substrates at different concentrations by blocking either one or both transport with specific inhibitors in the coexpression system.	Ciprofloxacin	33-46	phosphoglycolate phosphatase	Gallus gallus	113-117
29725709-7	2018	Among these drugs, enrofloxacin, ciprofloxacin, tilmicosin, ampicillin, and clindamycin were the cosubstrates of P-gp and BCRP, however, chicken BCRP and P-gp exhibit different affinities to the shared substrates at different concentrations by blocking either one or both transport with specific inhibitors in the coexpression system.	Ciprofloxacin	33-46	phosphoglycolate phosphatase	Gallus gallus	154-158
29725709-7	2018	Among these drugs, enrofloxacin, ciprofloxacin, tilmicosin, ampicillin, and clindamycin were the cosubstrates of P-gp and BCRP, however, chicken BCRP and P-gp exhibit different affinities to the shared substrates at different concentrations by blocking either one or both transport with specific inhibitors in the coexpression system.	tilmicosin	48-58	phosphoglycolate phosphatase	Gallus gallus	113-117
29725709-7	2018	Among these drugs, enrofloxacin, ciprofloxacin, tilmicosin, ampicillin, and clindamycin were the cosubstrates of P-gp and BCRP, however, chicken BCRP and P-gp exhibit different affinities to the shared substrates at different concentrations by blocking either one or both transport with specific inhibitors in the coexpression system.	tilmicosin	48-58	phosphoglycolate phosphatase	Gallus gallus	154-158
29725709-7	2018	Among these drugs, enrofloxacin, ciprofloxacin, tilmicosin, ampicillin, and clindamycin were the cosubstrates of P-gp and BCRP, however, chicken BCRP and P-gp exhibit different affinities to the shared substrates at different concentrations by blocking either one or both transport with specific inhibitors in the coexpression system.	Ampicillin	60-70	phosphoglycolate phosphatase	Gallus gallus	113-117