PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
32565732-3	2020	In this study, we built a lipopolysaccharide- (LPS-) induced ALI mouse model to illustrate the effect of PGRN on regulation of Treg differentiation and modulation of IL-10 promoting macrophage polarization.	treg	127-131	granulin	Mus musculus	105-109
32565732-4	2020	We found that the proportion of Tregs in splenic mononuclear cells and peripheral blood mononuclear cells was higher after treatment with PGRN.	tregs	32-37	granulin	Mus musculus	138-142
32565732-5	2020	The increased proportion of Tregs after PGRN intratracheal instillation was consistent with the decreased severity of lung injury, the reduction of proinflammatory cytokines, and the increase of anti-inflammatory cytokines.	tregs	28-33	granulin	Mus musculus	40-44
32178712-10	2020	Combining G418 with a PTC readthrough enhancer increased PGRN levels over G418 treatment alone in vitro.	antibiotic G 418	10-14	granulin	Mus musculus	57-61
32168097-5	2020	First, we treated wild type and PGRN-deficient mice with seizure-inducible drugs, bicuculline or N-methyl-D-aspartate (NMDA), which provoke hyperexcitement of neurons.	Bicuculline	82-93	granulin	Mus musculus	32-36
32168097-5	2020	First, we treated wild type and PGRN-deficient mice with seizure-inducible drugs, bicuculline or N-methyl-D-aspartate (NMDA), which provoke hyperexcitement of neurons.	N-Methylaspartate	97-117	granulin	Mus musculus	32-36
32168097-5	2020	First, we treated wild type and PGRN-deficient mice with seizure-inducible drugs, bicuculline or N-methyl-D-aspartate (NMDA), which provoke hyperexcitement of neurons.	N-Methylaspartate	119-123	granulin	Mus musculus	32-36
32168097-6	2020	PGRN-deficient mice showed higher intensity of seizure and longer duration of convulsive behavior when treated with either bicuculline or NMDA.	Bicuculline	123-134	granulin	Mus musculus	0-4
32168097-6	2020	PGRN-deficient mice showed higher intensity of seizure and longer duration of convulsive behavior when treated with either bicuculline or NMDA.	N-Methylaspartate	138-142	granulin	Mus musculus	0-4
32178712-10	2020	Combining G418 with a PTC readthrough enhancer increased PGRN levels over G418 treatment alone in vitro.	antibiotic G 418	74-78	granulin	Mus musculus	57-61
32178712-12	2020	Increasing PGRN through G418-mediated PTC readthrough normalized this abnormal lysosomal phenotype in R493X-/- KI neuronal cultures.	antibiotic G 418	24-28	granulin	Mus musculus	11-15
32178712-13	2020	A single intracerebroventricular injection of G418 induced GRN PTC readthrough in 6-week-old AAV-GRN-R493X-V5 mice.	antibiotic G 418	46-50	granulin	Mus musculus	59-62
32178712-13	2020	A single intracerebroventricular injection of G418 induced GRN PTC readthrough in 6-week-old AAV-GRN-R493X-V5 mice.	antibiotic G 418	46-50	granulin	Mus musculus	97-100
31679689-9	2020	Additionally, PGRN-regulated ischemic stroke was related to ROS accumulation that MCAO-mice with PGRN knockdown exhibited severe oxidative stress, as proved by the aggravated malondialdehyde (MDA) and lipid peroxidation (LPO) contents, and the decreased superoxide dismutase (SOD) activity.	Malondialdehyde	175-190	granulin	Mus musculus	14-18
31869774-3	2020	In recent years, progranulin (PGRN), a cysteine-rich secretory protein (CRISP), has been found to play a crucial role in sepsis.	Cysteine	39-47	granulin	Mus musculus	17-28
31869774-3	2020	In recent years, progranulin (PGRN), a cysteine-rich secretory protein (CRISP), has been found to play a crucial role in sepsis.	Cysteine	39-47	granulin	Mus musculus	30-34
31454754-5	2020	Fatty acids, bile acids and incretins GLP-1 and GIP-1 exerted potent and differential effects on progranulin secretion.	Fatty Acids	0-11	granulin	Mus musculus	97-108
31454754-5	2020	Fatty acids, bile acids and incretins GLP-1 and GIP-1 exerted potent and differential effects on progranulin secretion.	Bile Acids and Salts	13-23	granulin	Mus musculus	97-108
31866375-7	2020	Furthermore, accumulation of lipofuscin and increases in senescence markers were observed in the hearts of PGRN KO mice, suggesting that PGRN deficiency led to enhanced aging of the heart.	Lipofuscin	29-39	granulin	Mus musculus	107-111
31866375-7	2020	Furthermore, accumulation of lipofuscin and increases in senescence markers were observed in the hearts of PGRN KO mice, suggesting that PGRN deficiency led to enhanced aging of the heart.	Lipofuscin	29-39	granulin	Mus musculus	137-141
31679689-9	2020	Additionally, PGRN-regulated ischemic stroke was related to ROS accumulation that MCAO-mice with PGRN knockdown exhibited severe oxidative stress, as proved by the aggravated malondialdehyde (MDA) and lipid peroxidation (LPO) contents, and the decreased superoxide dismutase (SOD) activity.	Malondialdehyde	175-190	granulin	Mus musculus	97-101
31679689-9	2020	Additionally, PGRN-regulated ischemic stroke was related to ROS accumulation that MCAO-mice with PGRN knockdown exhibited severe oxidative stress, as proved by the aggravated malondialdehyde (MDA) and lipid peroxidation (LPO) contents, and the decreased superoxide dismutase (SOD) activity.	Malondialdehyde	192-195	granulin	Mus musculus	14-18
31679689-9	2020	Additionally, PGRN-regulated ischemic stroke was related to ROS accumulation that MCAO-mice with PGRN knockdown exhibited severe oxidative stress, as proved by the aggravated malondialdehyde (MDA) and lipid peroxidation (LPO) contents, and the decreased superoxide dismutase (SOD) activity.	Malondialdehyde	192-195	granulin	Mus musculus	97-101
31679689-9	2020	Additionally, PGRN-regulated ischemic stroke was related to ROS accumulation that MCAO-mice with PGRN knockdown exhibited severe oxidative stress, as proved by the aggravated malondialdehyde (MDA) and lipid peroxidation (LPO) contents, and the decreased superoxide dismutase (SOD) activity.	Superoxides	254-264	granulin	Mus musculus	14-18
31679689-9	2020	Additionally, PGRN-regulated ischemic stroke was related to ROS accumulation that MCAO-mice with PGRN knockdown exhibited severe oxidative stress, as proved by the aggravated malondialdehyde (MDA) and lipid peroxidation (LPO) contents, and the decreased superoxide dismutase (SOD) activity.	Superoxides	254-264	granulin	Mus musculus	97-101
31679689-12	2020	Therefore, promoting PGRN expression could reduced cerebral I/R-induced brain injury by suppressing neroptosis and associated reactive oxygen species (ROS) production.	Oxygen	135-141	granulin	Mus musculus	21-25
31290458-11	2019	Atsttrin treatment reduced the lipopolysaccharide-induced increase in the protein and mRNA levels of tumor necrosis factor-alpha, interleukin-1beta, matrix metalloproteinase-3 and inducible nitric oxide synthase in the brain of progranulin knockout mice.	atsttrin	0-8	granulin	Mus musculus	228-239
31290458-13	2019	Furthermore, Atsttrin significantly reduced the levels of phospho-nuclear factor kappa B inhibitor a in the brain of lipopolysaccharide-treated progranulin knockout mice and astrocytes, and it decreased the expression of nuclear factor kappa B2 in astrocytes.	atsttrin	13-21	granulin	Mus musculus	144-155
31108104-0	2019	Progranulin Promotes Bleomycin-Induced Skin Sclerosis by Enhancing Transforming Growth Factor-beta/Smad3 Signaling through Up-Regulation of Transforming Growth Factor-beta Type I Receptor.	Bleomycin	21-30	granulin	Mus musculus	0-11
31402399-5	2019	PGRN was downregulated in the kidney from diabetic mice and podocytes under a high-glucose (HG) condition.	Glucose	83-90	granulin	Mus musculus	0-4
31402399-11	2019	KEY MESSAGES:   PGRN level is reduced in kidney of diabetic mice and high-glucose-treated podocytes.	Glucose	74-81	granulin	Mus musculus	16-20
31402399-13	2019	PGRN protects against high-glucose-induced podocyte injury.	Glucose	27-34	granulin	Mus musculus	0-4
31402399-14	2019	PGRN restores high-glucose-inhibited autophagy in podocytes.	Glucose	19-26	granulin	Mus musculus	0-4
31285425-4	2019	We found that the level of PGRN was significantly reduced in the kidney from STZ-induced diabetic mice and patients with biopsy-proven DN compared with healthy controls.	Streptozocin	77-80	granulin	Mus musculus	27-31
31591383-8	2019	In vitro treatment of primary macrophages and Raw 264.7 cells with conditioned media from hepatocytes pre-treated with PGRN prior to stimulation with tumor necrosis factor (TNF)-alpha or palmitate decreased their expression of pro-inflammatory genes.	Palmitates	187-196	granulin	Mus musculus	119-123
31108104-3	2019	Because systemic sclerosis (SSc) is a prototypical fibrosis-related disorder, here, the aim was to clarify the role and mechanism of PGRN in bleomycin (BLM)-induced model of SSc for the first time.	Bleomycin	141-150	granulin	Mus musculus	133-137
28982738-8	2018	In BSMs of the repeatedly antigen-challenged mice, an augmented contractile responsiveness to acetylcholine with an upregulation of RhoA was observed: both the events were ameliorated by pretreatments with PGRN intranasally.	Acetylcholine	94-107	granulin	Mus musculus	206-210
30559071-0	2019	AAV-Mediated Progranulin Delivery to a Mouse Model of Progranulin Deficiency Causes T Cell-Mediated Toxicity.	CHEMBL2031461	0-3	granulin	Mus musculus	13-24
30559071-0	2019	AAV-Mediated Progranulin Delivery to a Mouse Model of Progranulin Deficiency Causes T Cell-Mediated Toxicity.	CHEMBL2031461	0-3	granulin	Mus musculus	54-65
30559071-3	2019	Here, we used AAV9 to deliver GRN to the lateral ventricle to achieve widespread expression in the Grn null mouse brain.	aav9	14-18	granulin	Mus musculus	30-33
30559071-3	2019	Here, we used AAV9 to deliver GRN to the lateral ventricle to achieve widespread expression in the Grn null mouse brain.	aav9	14-18	granulin	Mus musculus	99-102
30510962-9	2018	Glimepiride elicited the same effects in all strains evaluated: four wild-type strains, as well as the transgenic Grn-/- and diabetic db/db mice.	glimepiride	0-11	granulin	Mus musculus	114-117
30212683-8	2018	Mechanistically, cultured progranulin-deficient macrophages exhibited increased lysosome-mediated exophagy of aggregated low-density lipoproteins resulting in increased cholesterol uptake and foam cell formation.	Cholesterol	169-180	granulin	Mus musculus	26-37
30212683-9	2018	CONCLUSIONS: We conclude that hematopoietic progranulin deficiency promotes diet-induced atherosclerosis in Ldlr-/- mice, possibly due to increased exophagy-mediated cholesterol uptake.	Cholesterol	166-177	granulin	Mus musculus	44-55
29378861-10	2018	The beneficial effects of AAV-Grn did not require progranulin binding to sortilin.	CHEMBL2031461	26-29	granulin	Mus musculus	30-33
29378861-16	2018	AAV-mediated progranulin delivery reduced lipofuscinosis in Grn-/- mice even after the onset of pathology.	CHEMBL2031461	0-3	granulin	Mus musculus	13-24
29378861-16	2018	AAV-mediated progranulin delivery reduced lipofuscinosis in Grn-/- mice even after the onset of pathology.	CHEMBL2031461	0-3	granulin	Mus musculus	60-63
29378861-19	2018	AAV-derived progranulin was delivered to lysosomes and corrected lysosomal abnormalities.	CHEMBL2031461	0-3	granulin	Mus musculus	12-23
29929528-3	2018	Heterozygous GRN mutation carriers develop FTD with TDP-43 pathology and exhibit signs of lysosomal dysfunction in the brain, with increased levels of lysosomal proteins and lipofuscin accumulation.	Lipofuscin	174-184	granulin	Mus musculus	13-16
26373796-6	2015	In addition, PGRN-deficient adipocytes were more refractory to tunicamycin- or dexamethasone-induced insulin resistance, indicating the causative role of the TNFR1 pathway in the action of PGRN.	Tunicamycin	63-74	granulin	Mus musculus	13-17
28899992-6	2017	We found that PGRN decline diminished GluN2B-containing NMDA receptor levels and density as well as NMDA-dependent tau phosphorylation.	N-Methylaspartate	56-60	granulin	Mus musculus	14-18
28903038-5	2017	PGRN loss leads to an accumulation of polyunsaturated triacylglycerides, as well as a reduction of diacylglycerides and phosphatidylserines in fibroblast and enriched lysosome lipidomes.	polyunsaturated triacylglycerides	38-71	granulin	Mus musculus	0-4
28903038-5	2017	PGRN loss leads to an accumulation of polyunsaturated triacylglycerides, as well as a reduction of diacylglycerides and phosphatidylserines in fibroblast and enriched lysosome lipidomes.	diacylglycerides	99-115	granulin	Mus musculus	0-4
28273689-6	2017	METHODS: First, PGRN expression was assessed in a mouse model of CS-induced emphysema and in AECs after exposure to CS extract (CSE).	Cesium	65-67	granulin	Mus musculus	16-20
28273689-6	2017	METHODS: First, PGRN expression was assessed in a mouse model of CS-induced emphysema and in AECs after exposure to CS extract (CSE).	Cesium	116-118	granulin	Mus musculus	16-20
28273689-10	2017	RESULTS: Our results revealed that PGRN expression was elevated in CS-exposed mouse lungs and CSE-treated AECs.	Cesium	67-69	granulin	Mus musculus	35-39
28143512-4	2017	RESULTS: Progranulin treatment increased iNOS expression, NO synthesis and ROS generation, and elevated protein expressions of CHOP, GRP78 and the phosphorylation of PERK, and caused a significant increase in Atg7 and LC3-II protein expression and a decreased p62 expression, and decreased insulin-stimulated tyrosine phosphorylation of IRS-1 and glucose uptake, demonstrating that progranulin activated oxidative stress and ER stress, elevated autophagy and induced insulin insensitivity in adipocytes and adipose tissue of mice.	ros	75-78	granulin	Mus musculus	9-20
28143512-4	2017	RESULTS: Progranulin treatment increased iNOS expression, NO synthesis and ROS generation, and elevated protein expressions of CHOP, GRP78 and the phosphorylation of PERK, and caused a significant increase in Atg7 and LC3-II protein expression and a decreased p62 expression, and decreased insulin-stimulated tyrosine phosphorylation of IRS-1 and glucose uptake, demonstrating that progranulin activated oxidative stress and ER stress, elevated autophagy and induced insulin insensitivity in adipocytes and adipose tissue of mice.	Tyrosine	309-317	granulin	Mus musculus	9-20
28143512-4	2017	RESULTS: Progranulin treatment increased iNOS expression, NO synthesis and ROS generation, and elevated protein expressions of CHOP, GRP78 and the phosphorylation of PERK, and caused a significant increase in Atg7 and LC3-II protein expression and a decreased p62 expression, and decreased insulin-stimulated tyrosine phosphorylation of IRS-1 and glucose uptake, demonstrating that progranulin activated oxidative stress and ER stress, elevated autophagy and induced insulin insensitivity in adipocytes and adipose tissue of mice.	Glucose	347-354	granulin	Mus musculus	9-20
28143512-6	2017	Furthermore, the administration of the ER stress inhibitor 4-phenyl butyric acid reversed the negative effect of progranulin in vivo.	4-phenylbutyric acid	59-80	granulin	Mus musculus	113-124
27341800-8	2016	RESULTS: Here, we performed a cell-based screen of a library of known autophagy-lysosome modulators and identified multiple novel activators of a human GRN promoter reporter including several common mTOR inhibitors and an mTOR-independent activator of autophagy, trehalose.	Trehalose	263-272	granulin	Mus musculus	152-155
27341800-10	2016	Trehalose dose-dependently increased GRN mRNA as well as intracellular and secreted PGRN in both mouse and human cell lines and this effect was independent of the transcription factor EB (TFEB).	Trehalose	0-9	granulin	Mus musculus	37-40
27341800-10	2016	Trehalose dose-dependently increased GRN mRNA as well as intracellular and secreted PGRN in both mouse and human cell lines and this effect was independent of the transcription factor EB (TFEB).	Trehalose	0-9	granulin	Mus musculus	84-88
27341800-12	2016	Finally, oral administration of trehalose to Grn haploinsufficient mice significantly increased PGRN expression in the brain.	Trehalose	32-41	granulin	Mus musculus	45-48
26701296-5	2016	We find that in most brain regions, both strains are susceptible to progranulin-mediated neuropathological phenotypes, including astrogliosis, microgliosis, and highly accelerated deposition of the aging pigment lipofuscin.	Lipofuscin	212-222	granulin	Mus musculus	68-79
26864916-0	2016	Progranulin suppresses titanium particle induced inflammatory osteolysis by targeting TNFalpha signaling.	Titanium	23-31	granulin	Mus musculus	0-11
26864916-3	2016	Here we report that titanium particles significantly induced PGRN expression in RAW264.7 cells and also in a mouse air-pouch model of inflammation.	Titanium	20-28	granulin	Mus musculus	61-65
26864916-5	2016	In addition, PGRN also significantly inhibited titanium particle-induced osteoclastogenesis and calvarial osteolysis in vitro, ex vivo and in vivo.	Titanium	47-55	granulin	Mus musculus	13-17
26864916-6	2016	Mechanistic studies demonstrated that the inhibition of PGRN on titanium particle induced-inflammation is primarily via neutralizing the titanium particle-activated TNFalpha/NF-kappaB signaling pathway and this is evidenced by the suppression of particle-induced IkappaB phosphorylation, NF-kappaB p65 nuclear translocation, and activity of the NF-kappaB-specific reporter gene.	Titanium	64-72	granulin	Mus musculus	56-60
26864916-6	2016	Mechanistic studies demonstrated that the inhibition of PGRN on titanium particle induced-inflammation is primarily via neutralizing the titanium particle-activated TNFalpha/NF-kappaB signaling pathway and this is evidenced by the suppression of particle-induced IkappaB phosphorylation, NF-kappaB p65 nuclear translocation, and activity of the NF-kappaB-specific reporter gene.	Titanium	137-145	granulin	Mus musculus	56-60
26864916-7	2016	Collectively, these findings not only demonstrate that PGRN plays an important role in inhibiting titanium particle-induced inflammation, but also provide a potential therapeutic agent for the prevention of wear debris-induced inflammation and osteolysis.	Titanium	98-106	granulin	Mus musculus	55-59
29258611-0	2017	Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models.	atsttrin	23-31	granulin	Mus musculus	0-11
29124108-2	2017	Nimodipine, a Food and Drug Administration-approved blood-brain barrier-penetrant calcium channel blocker, increased PGRN levels in PGRN-deficient murine models.	Nimodipine	0-10	granulin	Mus musculus	117-121
28126008-9	2017	However, progranulin deficiency results in accumulation of TMEM106B protein from the transgene expression during aging, which is accompanied by exaggerated lysosomal abnormalities and increased lipofuscin accumulation.	Lipofuscin	194-204	granulin	Mus musculus	9-20
27629805-9	2016	At the behavioral level, further inhibition of the autophagic flux by hydroxychloroquine intensified cold and heat nociception after sciatic nerve injury and offset the pain protection provided by progranulin.	Hydroxychloroquine	70-88	granulin	Mus musculus	197-208
27341800-12	2016	Finally, oral administration of trehalose to Grn haploinsufficient mice significantly increased PGRN expression in the brain.	Trehalose	32-41	granulin	Mus musculus	96-100
27341800-13	2016	CONCLUSIONS: This work reports several novel autophagy-lysosome modulators that enhance PGRN expression and identifies trehalose as a promising therapeutic for raising PGRN levels to treat multiple neurodegenerative diseases.	Trehalose	119-128	granulin	Mus musculus	168-172
26373796-6	2015	In addition, PGRN-deficient adipocytes were more refractory to tunicamycin- or dexamethasone-induced insulin resistance, indicating the causative role of the TNFR1 pathway in the action of PGRN.	Dexamethasone	79-92	granulin	Mus musculus	13-17
26039714-4	2015	Furthermore, treatment of mice with phenyl butyric acid (PBA), a chemical chaperone alleviating ER stress, resulted in a significant restoration of systemic insulin sensitivity and recovery of insulin signaling induced by PGRN.	4-phenylbutyric acid	36-55	granulin	Mus musculus	222-226
26206194-0	2015	Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with alpha7 nicotinic acetylcholine receptor agonists.	Acetylcholine	119-132	granulin	Mus musculus	70-81
26206194-6	2015	Treatment with ABT-107 also reduced microgliosis, decreased TNFalpha levels, and reduced compulsive behavior in progranulin-deficient mice.	5-(6-(1-azabicyclo(2,2,2)oct-3-yloxy)pyridazin-3-yl)-1H-indole	15-22	granulin	Mus musculus	112-123
25626394-7	2015	We demonstrated that PGRN expression was dramatically enhanced in the psoriasis-like lesions of TPA-treated WT mice, in accordance with human psoriatic lesions.	Tetradecanoylphorbol Acetate	96-99	granulin	Mus musculus	21-25
25626394-8	2015	Surprisingly, PGRN(-/-) mice were more sensitive to the development of TPA-induced psoriasis-like inflammation.	Tetradecanoylphorbol Acetate	71-74	granulin	Mus musculus	14-18
25626394-9	2015	The mechanism underlying this increased sensitivity of PGRN(-/-) mice to TPA-induced psoriasis-like inflammation was impaired differentiation of regulatory T cells in lymph nodes and decreased recruitment of these cells in the affected skin, which results in more severe inflammation.	Tetradecanoylphorbol Acetate	73-76	granulin	Mus musculus	55-59
25607110-4	2015	We also observed that PGRN deficiency (Grn(-/-) mice) significantly aggravated renal injury as evidenced by higher serum creatinine, more severe morphological injury, increased tubular epithelial cell death, and tubulointerstitial neutrophil and macrophage infiltration versus wild-type mice.	Creatinine	121-131	granulin	Mus musculus	39-42
26039714-4	2015	Furthermore, treatment of mice with phenyl butyric acid (PBA), a chemical chaperone alleviating ER stress, resulted in a significant restoration of systemic insulin sensitivity and recovery of insulin signaling induced by PGRN.	4-phenylbutyric acid	57-60	granulin	Mus musculus	222-226
26039714-6	2015	Whereas PGRN-deficient hepatocytes and adipocytes were more refractory to palmitate-induced insulin resistance, indicating the causative role of the PERK-eIF2alpha axis of the ER stress response in action of PGRN.	Palmitates	74-83	granulin	Mus musculus	8-12
25060136-6	2014	Intriguingly, subtoxic level of H2O2 induced expression of a growth factor, progranulin (PGRN), and exogenous PGRN pretreatment attenuated HT22 cell death induced by high concentrations of H2O2 in Erk1/2-dependent manner.	Hydrogen Peroxide	32-36	granulin	Mus musculus	76-87
25387791-4	2014	PGRN-deficient mice became highly susceptible to DSS- and TNBS-induced colitis, whereas recombinant PGRN ameliorated the pathology and reduced the histological score in both DSS and TNBS colitis models.	Dextran Sulfate	49-52	granulin	Mus musculus	0-4
25387791-5	2014	In addition, hematopoietic-derived PGRN was critical for protection against DSS-induced colitis, and lack of PGRN signaling in CD4+ T cells also exacerbated experimental colitis.	Dextran Sulfate	76-79	granulin	Mus musculus	35-39
24804730-8	2014	When PGRN expression was elevated in the SNC, nigrostriatal neurons were protected from MPTP toxicity in mice, along with a preservation of striatal dopamine content and turnover.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	88-92	granulin	Mus musculus	5-9
24804730-8	2014	When PGRN expression was elevated in the SNC, nigrostriatal neurons were protected from MPTP toxicity in mice, along with a preservation of striatal dopamine content and turnover.	Dopamine	149-157	granulin	Mus musculus	5-9
24804730-9	2014	Further, protection of nigrostriatal neurons by PGRN gene therapy was accompanied by reductions in markers of MPTP-induced inflammation and apoptosis as well as a complete preservation of locomotor function.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	110-114	granulin	Mus musculus	48-52
25060136-6	2014	Intriguingly, subtoxic level of H2O2 induced expression of a growth factor, progranulin (PGRN), and exogenous PGRN pretreatment attenuated HT22 cell death induced by high concentrations of H2O2 in Erk1/2-dependent manner.	Hydrogen Peroxide	32-36	granulin	Mus musculus	89-93
25060136-6	2014	Intriguingly, subtoxic level of H2O2 induced expression of a growth factor, progranulin (PGRN), and exogenous PGRN pretreatment attenuated HT22 cell death induced by high concentrations of H2O2 in Erk1/2-dependent manner.	Hydrogen Peroxide	32-36	granulin	Mus musculus	110-114
25060136-6	2014	Intriguingly, subtoxic level of H2O2 induced expression of a growth factor, progranulin (PGRN), and exogenous PGRN pretreatment attenuated HT22 cell death induced by high concentrations of H2O2 in Erk1/2-dependent manner.	Hydrogen Peroxide	189-193	granulin	Mus musculus	76-87
25060136-6	2014	Intriguingly, subtoxic level of H2O2 induced expression of a growth factor, progranulin (PGRN), and exogenous PGRN pretreatment attenuated HT22 cell death induced by high concentrations of H2O2 in Erk1/2-dependent manner.	Hydrogen Peroxide	189-193	granulin	Mus musculus	89-93
25060136-6	2014	Intriguingly, subtoxic level of H2O2 induced expression of a growth factor, progranulin (PGRN), and exogenous PGRN pretreatment attenuated HT22 cell death induced by high concentrations of H2O2 in Erk1/2-dependent manner.	Hydrogen Peroxide	189-193	granulin	Mus musculus	110-114
23847387-10	2013	In addition, lack of PGRN leads to accumulate excessive cholesterol in the macrophages and alter HDL-associated proteins.	Cholesterol	56-67	granulin	Mus musculus	21-25
24233842-10	2014	Furthermore, progranulin phosphorylated extracellular signal-regulated kinase, cAMP response element binding protein, and hepatocyte growth factor receptor, and protein kinase C signaling pathways were involved in the protective effects of progranulin.	Cyclic AMP	79-83	granulin	Mus musculus	13-24
24233842-10	2014	Furthermore, progranulin phosphorylated extracellular signal-regulated kinase, cAMP response element binding protein, and hepatocyte growth factor receptor, and protein kinase C signaling pathways were involved in the protective effects of progranulin.	Cyclic AMP	79-83	granulin	Mus musculus	240-251
23702345-4	2013	Administration of 3-nitropropionic acid, quinolinic acid, kainic acid, and pilocarpine induced robust and measurable neuronal cell death in affected brain regions, but no differential cell death was observed between Grn(+/+) and Grn(-/-) mice.	Pilocarpine	75-86	granulin	Mus musculus	229-232
23041626-4	2012	When exposed acutely to 1-methyl-4-(2"-methylphenyl)-1,2,3,6-tetrahydrophine (MPTP), mice lacking PGRN (Grn-/-) showed more neuron loss and increased microgliosis compared with wild-type mice.	1-methyl-4-(2"-methylphenyl)-1,2,3,6-tetrahydrophine	24-76	granulin	Mus musculus	98-102
23887054-0	2013	Progranulin promotes activation of microglia/macrophage after pilocarpine-induced status epilepticus.	Pilocarpine	62-73	granulin	Mus musculus	0-11
23887054-3	2013	Here we report that both protein and mRNA levels of cortical and hippocampal PGRN are significantly enhanced following pilocarpine-induced status epilepticus.	Pilocarpine	119-130	granulin	Mus musculus	77-81
23887054-6	2013	However, with pilocarpine-induced status epilepticus, PGRN application significantly increases the number of CD11b(+) microglia/macrophages in the dentate gyrus, without affecting the extent of hilar cell death.	Pilocarpine	14-25	granulin	Mus musculus	54-58
23669357-5	2013	PGRN-/- mice exhibited more severe inflammation following induction of oxazolone (OXA).	Oxazolone	71-80	granulin	Mus musculus	0-4
23669357-5	2013	PGRN-/- mice exhibited more severe inflammation following induction of oxazolone (OXA).	Oxazolone	82-85	granulin	Mus musculus	0-4
22771460-10	2013	Finally, crebinostat treatment of cultured mouse primary neurons was found to upregulate Bdnf (brain-derived neurotrophic factor) and Grn (granulin) and downregulate Mapt (tau) gene expression-genes implicated in aging-related cognitive decline and cognitive disorders.	(7-(2-((1,1'-biphenyl)-4-ylmethylene)hydrazinyl)-N-hydroxy-7-oxoheptanamide)	9-20	granulin	Mus musculus	134-137
22771460-10	2013	Finally, crebinostat treatment of cultured mouse primary neurons was found to upregulate Bdnf (brain-derived neurotrophic factor) and Grn (granulin) and downregulate Mapt (tau) gene expression-genes implicated in aging-related cognitive decline and cognitive disorders.	(7-(2-((1,1'-biphenyl)-4-ylmethylene)hydrazinyl)-N-hydroxy-7-oxoheptanamide)	9-20	granulin	Mus musculus	139-147
23041626-6	2012	Consistent with this, conditional mutants lacking PGRN in microglia exhibited MPTP-induced phenotypes similar to Grn-/- mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	78-82	granulin	Mus musculus	50-54
23041626-4	2012	When exposed acutely to 1-methyl-4-(2"-methylphenyl)-1,2,3,6-tetrahydrophine (MPTP), mice lacking PGRN (Grn-/-) showed more neuron loss and increased microgliosis compared with wild-type mice.	1-methyl-4-(2"-methylphenyl)-1,2,3,6-tetrahydrophine	24-76	granulin	Mus musculus	104-107
22539775-7	2012	GRN-529 reduced repetitive behaviors in three cohorts of BTBR mice at doses that did not induce sedation in control assays of open field locomotion.	btbr	57-61	granulin	Mus musculus	0-3
22539775-9	2012	Further, GRN-529 partially reversed the striking lack of sociability in BTBR mice on some parameters of social approach and reciprocal social interactions.	btbr	72-76	granulin	Mus musculus	9-12
21504803-7	2011	Risedronate was also able to induce the expression and the secretion of the growth factor pro-granulin.	Risedronic Acid	0-11	granulin	Mus musculus	90-102
21933869-4	2011	In adult rodents, PGRN was highly expressed in periventricular tanycytes and in hypothalamic neurons, which are known to contain glucose-sensing machinery.	Glucose	129-136	granulin	Mus musculus	18-22
21933869-5	2011	Hypothalamic PGRN expression levels were decreased under low-energy conditions (starvation and 2-deoxy-D-glucose administration) but increased under high-energy condition (postprandially).	Deoxyglucose	95-112	granulin	Mus musculus	13-17
21933869-6	2011	Intracerebrovetricular administration of PGRN significantly suppressed nocturnal feeding as well as hyperphagia induced by 2-deoxyglucose, neuropeptide Y, and Agouti-related peptide.	Deoxyglucose	123-137	granulin	Mus musculus	41-45
22225875-2	2012	By differential proteome analysis of cellular models of insulin resistance, we identified progranulin (PGRN) as an adipokine induced by TNF-alpha and dexamethasone.	Dexamethasone	150-163	granulin	Mus musculus	90-101
22225875-2	2012	By differential proteome analysis of cellular models of insulin resistance, we identified progranulin (PGRN) as an adipokine induced by TNF-alpha and dexamethasone.	Dexamethasone	150-163	granulin	Mus musculus	103-107
22225875-3	2012	PGRN in blood and adipose tissues was markedly increased in obese mouse models and was normalized with treatment of pioglitazone, an insulin-sensitizing agent.	Pioglitazone	116-128	granulin	Mus musculus	0-4
21540081-8	2011	We also investigated the signaling mechanism(s) that mediate PGRN-induced NPC proliferation and found that phosphorylation of serine 9 (S9) of glycogen synthase kinase 3-beta (GSK3beta), which was dependent on phosphatidylinositol 3-kinase (PI3K) activity, was induced by PGRN treatment.	Serine	126-132	granulin	Mus musculus	61-65
21540081-8	2011	We also investigated the signaling mechanism(s) that mediate PGRN-induced NPC proliferation and found that phosphorylation of serine 9 (S9) of glycogen synthase kinase 3-beta (GSK3beta), which was dependent on phosphatidylinositol 3-kinase (PI3K) activity, was induced by PGRN treatment.	Serine	126-132	granulin	Mus musculus	272-276
20667979-4	2010	Eighteen-month-old progranulin-deficient mice demonstrated impaired spatial learning and memory in the Morris water maze.	Water	110-115	granulin	Mus musculus	19-30
22028881-0	2011	Progranulin, a glycoprotein deficient in frontotemporal dementia, is a novel substrate of several protein disulfide isomerase family proteins.	Disulfides	106-115	granulin	Mus musculus	0-11
20731760-5	2010	Furthermore, proteasomal inhibition with MG132 caused increased caspase-mediated TDP-43 fragmentation and accumulation of detergent-insoluble 35- and 25-kDa C-terminal fragments in Grn(-/-) neurons and mouse embryonic fibroblasts.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	41-46	granulin	Mus musculus	181-184
18676772-10	2008	GRN163L-induced cell death could also be expedited by addition of the chemotherapeutic agents doxorubicin and ritonavir.	Doxorubicin	94-105	granulin	Mus musculus	0-3
19860916-1	2009	BACKGROUND: Progranulin is a secreted high molecular weight growth factor bearing seven and one half copies of the cysteine-rich granulin-epithelin motif.	Cysteine	115-123	granulin	Mus musculus	12-23
20522652-7	2010	Neuropathologically, GRN(-/+) were indistinguishable from controls; however, GRN(-/-) mice developed age-associated, abnormal intraneuronal ubiquitin-positive autofluorescent lipofuscin.	Lipofuscin	175-185	granulin	Mus musculus	77-80
20522652-8	2010	Lipofuscin was noted in aged GRN(+/+) mice at levels comparable with those of young GRN(-/-) mice.	Lipofuscin	0-10	granulin	Mus musculus	29-32
19557827-7	2009	Consistent with an important role of inflammatory responses in AD, we identified progranulin (mouse Grn; human GRN) as one of the top ten up-regulated molecules in Tg2576 ( approximately 8-fold increased) and APPPS1 ( approximately 2-fold increased) mice compared to littermate controls, and among the eight significantly up-regulated molecules common to both mouse models.	tg2576	164-170	granulin	Mus musculus	81-92
19557827-7	2009	Consistent with an important role of inflammatory responses in AD, we identified progranulin (mouse Grn; human GRN) as one of the top ten up-regulated molecules in Tg2576 ( approximately 8-fold increased) and APPPS1 ( approximately 2-fold increased) mice compared to littermate controls, and among the eight significantly up-regulated molecules common to both mouse models.	tg2576	164-170	granulin	Mus musculus	100-103
18676772-10	2008	GRN163L-induced cell death could also be expedited by addition of the chemotherapeutic agents doxorubicin and ritonavir.	Ritonavir	110-119	granulin	Mus musculus	0-3
11676011-1	2001	Grifolan, GRN, is a fungal antitumor beta-glucan isolated from Grifola frondosa.	beta-Glucans	37-48	granulin	Mus musculus	10-13
16397023-9	2006	CONCLUSION: These data suggest that expression of PCDGF/GP88 confers resistance to dexamethasone and increase tumorigenesis of multiple myeloma cells in mouse xenografts.	Dexamethasone	83-96	granulin	Mus musculus	50-55
14996734-7	2004	The PCDGF/GP88-overexpressing cells formed tumors in ovariectomized nude mice in the absence of estradiol and in its presence, in contrast to MCF-7 cells.	Estradiol	96-105	granulin	Mus musculus	4-9
18469036-6	2008	Comparative sequence analysis revealed that exons 1 and 2 of mink progranulin share 86.6, 82.4, and 94.9% of nucleic acid sequence identity with the human, mouse, and dog sequences respectively, and indicated that the invariable residues of the cysteine-rich motifs of progranulin are well conserved in the mink sequence.	Cysteine	245-253	granulin	Mus musculus	66-77
16873554-4	2006	All-trans retinoic acid (ATRA) increased pgrn mRNA levels in myelomonocytic cells (CD34(+) progenitors; monoblastic U-937; monocytic THP-1; progranulocytic HL-60; macrophage RAW 264.7) but not in nonmyeloid cells tested.	Tretinoin	10-23	granulin	Mus musculus	41-45
16873554-4	2006	All-trans retinoic acid (ATRA) increased pgrn mRNA levels in myelomonocytic cells (CD34(+) progenitors; monoblastic U-937; monocytic THP-1; progranulocytic HL-60; macrophage RAW 264.7) but not in nonmyeloid cells tested.	Tretinoin	25-29	granulin	Mus musculus	41-45
16873554-6	2006	Differentiation agents DMSO, and, in U-937 only, phorbol ester [phorbol 12-myristate,13-acetate (PMA)] elevated pgrn mRNA expression late in differentiation, suggestive of roles for pgrn in more mature terminally differentiated granulocyte/monocytes rather than during growth or differentiation.	Phorbol Esters	49-62	granulin	Mus musculus	112-116
16873554-6	2006	Differentiation agents DMSO, and, in U-937 only, phorbol ester [phorbol 12-myristate,13-acetate (PMA)] elevated pgrn mRNA expression late in differentiation, suggestive of roles for pgrn in more mature terminally differentiated granulocyte/monocytes rather than during growth or differentiation.	Phorbol Esters	49-62	granulin	Mus musculus	182-186
16873554-6	2006	Differentiation agents DMSO, and, in U-937 only, phorbol ester [phorbol 12-myristate,13-acetate (PMA)] elevated pgrn mRNA expression late in differentiation, suggestive of roles for pgrn in more mature terminally differentiated granulocyte/monocytes rather than during growth or differentiation.	phorbol-12-myristate	64-84	granulin	Mus musculus	112-116
16873554-6	2006	Differentiation agents DMSO, and, in U-937 only, phorbol ester [phorbol 12-myristate,13-acetate (PMA)] elevated pgrn mRNA expression late in differentiation, suggestive of roles for pgrn in more mature terminally differentiated granulocyte/monocytes rather than during growth or differentiation.	phorbol-12-myristate	64-84	granulin	Mus musculus	182-186
16873554-6	2006	Differentiation agents DMSO, and, in U-937 only, phorbol ester [phorbol 12-myristate,13-acetate (PMA)] elevated pgrn mRNA expression late in differentiation, suggestive of roles for pgrn in more mature terminally differentiated granulocyte/monocytes rather than during growth or differentiation.	13-acetate	85-95	granulin	Mus musculus	112-116
16873554-6	2006	Differentiation agents DMSO, and, in U-937 only, phorbol ester [phorbol 12-myristate,13-acetate (PMA)] elevated pgrn mRNA expression late in differentiation, suggestive of roles for pgrn in more mature terminally differentiated granulocyte/monocytes rather than during growth or differentiation.	13-acetate	85-95	granulin	Mus musculus	182-186
16873554-6	2006	Differentiation agents DMSO, and, in U-937 only, phorbol ester [phorbol 12-myristate,13-acetate (PMA)] elevated pgrn mRNA expression late in differentiation, suggestive of roles for pgrn in more mature terminally differentiated granulocyte/monocytes rather than during growth or differentiation.	Tetradecanoylphorbol Acetate	97-100	granulin	Mus musculus	112-116
16873554-6	2006	Differentiation agents DMSO, and, in U-937 only, phorbol ester [phorbol 12-myristate,13-acetate (PMA)] elevated pgrn mRNA expression late in differentiation, suggestive of roles for pgrn in more mature terminally differentiated granulocyte/monocytes rather than during growth or differentiation.	Tetradecanoylphorbol Acetate	97-100	granulin	Mus musculus	182-186
16873554-8	2006	In U-937, ATRA and chemical differentiation agents greatly increased pgrn mRNA stability, whereas, in HL-60, ATRA accelerated pgrn mRNA turnover.	Tretinoin	10-14	granulin	Mus musculus	69-73
16873554-9	2006	The initial upregulation of pgrn mRNA after stimulation with ATRA was independent of de novo protein synthesis in U-937 but not HL-60.	Tretinoin	61-65	granulin	Mus musculus	28-32
16873554-10	2006	Chemical blockade of nuclear factor-kappaB (NF-kappaB) activation impaired ATRA-stimulated pgrn expression in HL-60 but not U-937, whereas in U-937 it blocked PMA-induced pgrn mRNA expression, suggestive of cell-specific roles for NF-kappaB in determining pgrn mRNA levels.	Tretinoin	75-79	granulin	Mus musculus	91-95
16873554-10	2006	Chemical blockade of nuclear factor-kappaB (NF-kappaB) activation impaired ATRA-stimulated pgrn expression in HL-60 but not U-937, whereas in U-937 it blocked PMA-induced pgrn mRNA expression, suggestive of cell-specific roles for NF-kappaB in determining pgrn mRNA levels.	Tretinoin	75-79	granulin	Mus musculus	171-175
16873554-10	2006	Chemical blockade of nuclear factor-kappaB (NF-kappaB) activation impaired ATRA-stimulated pgrn expression in HL-60 but not U-937, whereas in U-937 it blocked PMA-induced pgrn mRNA expression, suggestive of cell-specific roles for NF-kappaB in determining pgrn mRNA levels.	Tretinoin	75-79	granulin	Mus musculus	171-175
15901638-7	2005	Studies of bromodeoxyuridine incorporation and immunodissection of the ICM revealed that progranulin was effective on the trophectoderm but not on the ICM.	Bromodeoxyuridine	11-28	granulin	Mus musculus	89-100
9826678-3	1998	Sequencing of PCDGF cDNA demonstrated its identity to the precursor of a family of 6-kDa double-cysteine-rich polypeptides called epithelins or granulins (epithelin/granulin precursor).	Cysteine	96-104	granulin	Mus musculus	14-19
9826678-3	1998	Sequencing of PCDGF cDNA demonstrated its identity to the precursor of a family of 6-kDa double-cysteine-rich polypeptides called epithelins or granulins (epithelin/granulin precursor).	Cysteine	96-104	granulin	Mus musculus	144-153
9826678-3	1998	Sequencing of PCDGF cDNA demonstrated its identity to the precursor of a family of 6-kDa double-cysteine-rich polypeptides called epithelins or granulins (epithelin/granulin precursor).	Cysteine	96-104	granulin	Mus musculus	130-139
9826678-3	1998	Sequencing of PCDGF cDNA demonstrated its identity to the precursor of a family of 6-kDa double-cysteine-rich polypeptides called epithelins or granulins (epithelin/granulin precursor).	Cysteine	96-104	granulin	Mus musculus	144-152
9571191-6	1998	125I-PCDGF was chemically crosslinked to cell surface receptors on CCL64 cells with disuccinimidyl suberate.	disuccinimidyl	84-98	granulin	Mus musculus	5-10
9571191-7	1998	A major crosslinked band of about 190 kDa with radiolabeled PCDGF was detected after SDS-PAGE, suggesting the presence of PCDGF binding sites with molecular weight of about 120 kDa.	Sodium Dodecyl Sulfate	85-88	granulin	Mus musculus	60-65
9571191-7	1998	A major crosslinked band of about 190 kDa with radiolabeled PCDGF was detected after SDS-PAGE, suggesting the presence of PCDGF binding sites with molecular weight of about 120 kDa.	Sodium Dodecyl Sulfate	85-88	granulin	Mus musculus	122-127
34428436-5	2021	Furthermore, curcumin treatment (50 mg/kg and 200 mg/kg, intragastrically) for 21 consecutive days suppressed the IMQ exposure-induced increase in PGRN expression.	Curcumin	13-21	granulin	Mus musculus	147-151
9556160-4	1998	A kinetic study of the activation of kupffer cells revealed that GRN could induce the enhanced production of cytokines and nitric oxide on 4 to 7 d after the administration.	Nitric Oxide	123-135	granulin	Mus musculus	65-68
9556160-9	1998	The above data suggest that GRN could activate murine kupffer cells to enhance the production of cytokines and nitric oxide, and that the activation required 4 or 7 d, at least, after the administration with GRN.	Nitric Oxide	111-123	granulin	Mus musculus	28-31
8593430-1	1995	In a previous study, we reported that one of the gel-forming (1-->3)-beta-D-glucans, grifolan (from Grifola frondosa, GRN), stimulated cytokine production from macrophages in vitro.	beta-D-Glucan	72-86	granulin	Mus musculus	121-124
8593430-7	1995	GRN-inducible TNF alpha release was reduced by co-culturing with SPG, SSG, or the soluble beta-glucan, laminarin (LAM).	spirogermanium	65-68	granulin	Mus musculus	0-3
8593430-7	1995	GRN-inducible TNF alpha release was reduced by co-culturing with SPG, SSG, or the soluble beta-glucan, laminarin (LAM).	Antimony Sodium Gluconate	70-73	granulin	Mus musculus	0-3
8593430-7	1995	GRN-inducible TNF alpha release was reduced by co-culturing with SPG, SSG, or the soluble beta-glucan, laminarin (LAM).	beta-Glucans	90-101	granulin	Mus musculus	0-3
8593430-7	1995	GRN-inducible TNF alpha release was reduced by co-culturing with SPG, SSG, or the soluble beta-glucan, laminarin (LAM).	laminaran	103-112	granulin	Mus musculus	0-3
8593430-7	1995	GRN-inducible TNF alpha release was reduced by co-culturing with SPG, SSG, or the soluble beta-glucan, laminarin (LAM).	laminaran	114-117	granulin	Mus musculus	0-3
8593430-10	1995	The inhibitory effect of LAM on the uptake of GRN by RAW264.7 cells was not completely correlated with TNF alpha release.	laminaran	25-28	granulin	Mus musculus	46-49
8496151-3	1993	PC cell-derived growth factor (PCDGF) was purified to homogeneity from PC cell-conditioned medium as an apparent 88-kDa protein by chromatography on heparin-Sepharose, Sephacryl S-200, and phenyl-Sepharose.	Heparin	149-156	granulin	Mus musculus	0-29
8496151-3	1993	PC cell-derived growth factor (PCDGF) was purified to homogeneity from PC cell-conditioned medium as an apparent 88-kDa protein by chromatography on heparin-Sepharose, Sephacryl S-200, and phenyl-Sepharose.	Heparin	149-156	granulin	Mus musculus	31-36
8496151-3	1993	PC cell-derived growth factor (PCDGF) was purified to homogeneity from PC cell-conditioned medium as an apparent 88-kDa protein by chromatography on heparin-Sepharose, Sephacryl S-200, and phenyl-Sepharose.	Sepharose	157-166	granulin	Mus musculus	0-29
8496151-3	1993	PC cell-derived growth factor (PCDGF) was purified to homogeneity from PC cell-conditioned medium as an apparent 88-kDa protein by chromatography on heparin-Sepharose, Sephacryl S-200, and phenyl-Sepharose.	Sepharose	157-166	granulin	Mus musculus	31-36
8496151-3	1993	PC cell-derived growth factor (PCDGF) was purified to homogeneity from PC cell-conditioned medium as an apparent 88-kDa protein by chromatography on heparin-Sepharose, Sephacryl S-200, and phenyl-Sepharose.	sephacryl S 200	168-183	granulin	Mus musculus	0-29
8496151-3	1993	PC cell-derived growth factor (PCDGF) was purified to homogeneity from PC cell-conditioned medium as an apparent 88-kDa protein by chromatography on heparin-Sepharose, Sephacryl S-200, and phenyl-Sepharose.	sephacryl S 200	168-183	granulin	Mus musculus	31-36
8496151-3	1993	PC cell-derived growth factor (PCDGF) was purified to homogeneity from PC cell-conditioned medium as an apparent 88-kDa protein by chromatography on heparin-Sepharose, Sephacryl S-200, and phenyl-Sepharose.	phenyl-sepharose	189-205	granulin	Mus musculus	0-29
8496151-3	1993	PC cell-derived growth factor (PCDGF) was purified to homogeneity from PC cell-conditioned medium as an apparent 88-kDa protein by chromatography on heparin-Sepharose, Sephacryl S-200, and phenyl-Sepharose.	phenyl-sepharose	189-205	granulin	Mus musculus	31-36
8496151-4	1993	Digestion with peptide-N-glycosidase F yielded an apparent 68-kDa protein component indicating that PCDGF is a glycoprotein containing about 20 kDa of carbohydrate.	Carbohydrates	151-163	granulin	Mus musculus	100-105
8496151-5	1993	Partial sequence from Edman degradation of peptide fragments obtained by digestion of PCDGF with cyanogen bromide and trypsin demonstrates that PCDGF contains regions of sequence identity to that deduced from the granulin or epithelin precursor cDNAs.	Cyanogen Bromide	97-113	granulin	Mus musculus	86-91
8496151-5	1993	Partial sequence from Edman degradation of peptide fragments obtained by digestion of PCDGF with cyanogen bromide and trypsin demonstrates that PCDGF contains regions of sequence identity to that deduced from the granulin or epithelin precursor cDNAs.	Cyanogen Bromide	97-113	granulin	Mus musculus	144-149
34934623-2	2021	Progranulin binding to tumor necrosis factor receptor (TNFR) and its derivative Atsttrin are effective for treating inflammatory arthritis.	atsttrin	80-88	granulin	Mus musculus	0-11
34428436-5	2021	Furthermore, curcumin treatment (50 mg/kg and 200 mg/kg, intragastrically) for 21 consecutive days suppressed the IMQ exposure-induced increase in PGRN expression.	Imiquimod	114-117	granulin	Mus musculus	147-151
34450028-2	2021	Here, we found that Grn-/- mice exhibit a global deficiency in bis(monoacylglycero)phosphate (BMP), an endolysosomal phospholipid we identified as a pH-dependent PGRN interactor as well as a redox-sensitive enhancer of lysosomal proteolysis and lipolysis.	bis(monoacylglyceryl)phosphate	94-97	granulin	Mus musculus	20-23
34289035-0	2021	Hydrogen peroxide induces progranulin expression to control neurite outgrowth in HT22 cells.	Hydrogen Peroxide	0-17	granulin	Mus musculus	26-37
34289035-4	2021	We observed that p38 MAP kinase was activated upon the addition of H2O2, and a selective p38 MAP kinase inhibitor, attenuated PGRN induction by H2O2.	Hydrogen Peroxide	67-71	granulin	Mus musculus	126-130
34289035-4	2021	We observed that p38 MAP kinase was activated upon the addition of H2O2, and a selective p38 MAP kinase inhibitor, attenuated PGRN induction by H2O2.	Hydrogen Peroxide	144-148	granulin	Mus musculus	126-130
34289035-5	2021	To explore the physiological role(s) of the PGRN induction, we first confirmed H2O2-dependent responses of HT22 cells and found that the length and number of neurites were increased by H2O2.	Hydrogen Peroxide	79-83	granulin	Mus musculus	44-48
34289035-5	2021	To explore the physiological role(s) of the PGRN induction, we first confirmed H2O2-dependent responses of HT22 cells and found that the length and number of neurites were increased by H2O2.	Hydrogen Peroxide	185-189	granulin	Mus musculus	44-48
34289035-6	2021	Pgrn knockdown experiments suggested these changes were mediated by H2O2-induced PGRN expression, at least in part.	Hydrogen Peroxide	68-72	granulin	Mus musculus	0-4
34289035-6	2021	Pgrn knockdown experiments suggested these changes were mediated by H2O2-induced PGRN expression, at least in part.	Hydrogen Peroxide	68-72	granulin	Mus musculus	81-85
34450028-2	2021	Here, we found that Grn-/- mice exhibit a global deficiency in bis(monoacylglycero)phosphate (BMP), an endolysosomal phospholipid we identified as a pH-dependent PGRN interactor as well as a redox-sensitive enhancer of lysosomal proteolysis and lipolysis.	bis(monoacylglyceryl)phosphate	94-97	granulin	Mus musculus	162-166
34450028-5	2021	PTV:PGRN rescued various Grn-/- phenotypes in primary murine macrophages and human iPSC-derived microglia, including oxidative stress, lysosomal dysfunction, and endomembrane damage.	2-[[5-(4-Pyridyl)-1h-1,2,4-Triazol-3-Yl]sulfanyl]-1-(2-Thiophenyl)ethanone	0-3	granulin	Mus musculus	4-8
34450028-5	2021	PTV:PGRN rescued various Grn-/- phenotypes in primary murine macrophages and human iPSC-derived microglia, including oxidative stress, lysosomal dysfunction, and endomembrane damage.	2-[[5-(4-Pyridyl)-1h-1,2,4-Triazol-3-Yl]sulfanyl]-1-(2-Thiophenyl)ethanone	0-3	granulin	Mus musculus	25-28
34374265-13	2021	In vitro experiments, compared with PBS group, PGRN level was decreased (P<0.05), IL-6 level was increased (P<0.01), phosphorylation of p38 was activated in IL-13 treatment group.	Lead	36-39	granulin	Mus musculus	47-51
34578829-1	2021	Trehalose, a sugar from fungi, mimics starvation due to a block of glucose transport and induces Transcription Factor EB- mediated autophagy, likely supported by the upregulation of progranulin.	Trehalose	0-9	granulin	Mus musculus	182-193
34578829-1	2021	Trehalose, a sugar from fungi, mimics starvation due to a block of glucose transport and induces Transcription Factor EB- mediated autophagy, likely supported by the upregulation of progranulin.	Sugars	13-18	granulin	Mus musculus	182-193
34578829-1	2021	Trehalose, a sugar from fungi, mimics starvation due to a block of glucose transport and induces Transcription Factor EB- mediated autophagy, likely supported by the upregulation of progranulin.	Glucose	67-74	granulin	Mus musculus	182-193
33157500-6	2021	In pregnant mice, we evaluated the effect of lipopolysaccharide-induced inflammation and progesterone effect modulation on cervical mRNA expression of SLPI and PGRN.	Progesterone	89-101	granulin	Mus musculus	160-164
34485593-6	2021	Mice heterologously expressing progranulin showed a reduction in lipofuscin deposits and microglia infiltration.	Lipofuscin	65-75	granulin	Mus musculus	31-42
35449211-10	2022	Interestingly, PGRN signaling decreased expression of EZH2 and treatment of the PGRN KO mice with the EZH2 specific inhibitor GSK343 rescued the defect in NKT2 differentiation, IL-4 generation, and PLZF expression.	GSK343	126-132	granulin	Mus musculus	15-19
35449211-10	2022	Interestingly, PGRN signaling decreased expression of EZH2 and treatment of the PGRN KO mice with the EZH2 specific inhibitor GSK343 rescued the defect in NKT2 differentiation, IL-4 generation, and PLZF expression.	GSK343	126-132	granulin	Mus musculus	80-84
35449211-11	2022	Altogether, We have revealed a new pathway (PGRN-EZH2-PLZF), which regulates the Th2 responses of iNKT cells and provides a potentially new target for asthma treatment.	th2	81-84	granulin	Mus musculus	44-48
35054815-7	2022	Moreover, higher aggregation of lipofuscin was observed in the brain tissue of PGRN-deficient mice compared with WT mice.	Lipofuscin	32-42	granulin	Mus musculus	79-83
33539798-5	2021	Meanwhile, 1 ng r-PGRN increased SVZ cell proliferation, as shown by a high number of bromodeoxyuridine-positive (BrdU+) cells and Ki-67+ cells in the ischemic ipsilateral SVZ 7 d after pMCAO.	Bromodeoxyuridine	86-103	granulin	Mus musculus	18-22
33539798-5	2021	Meanwhile, 1 ng r-PGRN increased SVZ cell proliferation, as shown by a high number of bromodeoxyuridine-positive (BrdU+) cells and Ki-67+ cells in the ischemic ipsilateral SVZ 7 d after pMCAO.	pmcao	186-191	granulin	Mus musculus	18-22
33539798-7	2021	PGRN also upregulated phosphorylation of ERK1/2 and Akt in the ipsilateral SVZ 3 d after pMCAO.	pmcao	89-94	granulin	Mus musculus	0-4
35095393-9	2021	The exception was RET, a neurotrophic tyrosine receptor kinase, which, when PGRN levels are high, shows increased expression and enhanced tyrosine phosphorylation.	Tyrosine	138-146	granulin	Mus musculus	76-80
35095393-10	2021	Other receptor tyrosine kinases also showed higher tyrosine phosphorylation when PGRN was elevated, suggesting a generalized enhancement of receptor activity.	Tyrosine	51-59	granulin	Mus musculus	81-85
33795008-2	2021	Up to 20% of familial FTLD cases are caused by progranulin (GRN) haploinsufficiency (FTD-GRN), with one of the most common causal variant being a nonsense mutation at arginine 493 (R493X).	Arginine	167-175	granulin	Mus musculus	47-58
33795008-2	2021	Up to 20% of familial FTLD cases are caused by progranulin (GRN) haploinsufficiency (FTD-GRN), with one of the most common causal variant being a nonsense mutation at arginine 493 (R493X).	Arginine	167-175	granulin	Mus musculus	60-63
33795008-2	2021	Up to 20% of familial FTLD cases are caused by progranulin (GRN) haploinsufficiency (FTD-GRN), with one of the most common causal variant being a nonsense mutation at arginine 493 (R493X).	Arginine	167-175	granulin	Mus musculus	89-92
33795008-3	2021	Recently, a genetic knockin FTD-GRN mouse model was generated bearing this GrnR493X mutation, at the analogous arginine in murine Grn.	Arginine	111-119	granulin	Mus musculus	32-35
33795008-3	2021	Recently, a genetic knockin FTD-GRN mouse model was generated bearing this GrnR493X mutation, at the analogous arginine in murine Grn.	Arginine	111-119	granulin	Mus musculus	75-78
33157500-9	2021	In pregnant mice, cervical mRNA expressions of PGRN and SLPI were increased in response to progesterone supplementation and were suppressed by a progesterone antagonist, mifepristone.	Progesterone	91-103	granulin	Mus musculus	47-51
33157500-9	2021	In pregnant mice, cervical mRNA expressions of PGRN and SLPI were increased in response to progesterone supplementation and were suppressed by a progesterone antagonist, mifepristone.	Progesterone	145-157	granulin	Mus musculus	47-51
33157500-9	2021	In pregnant mice, cervical mRNA expressions of PGRN and SLPI were increased in response to progesterone supplementation and were suppressed by a progesterone antagonist, mifepristone.	Mifepristone	170-182	granulin	Mus musculus	47-51
32985120-8	2020	However, three independent studies in this issue report that completely removing Tmem106b from Grn knockout mice leads to clear exacerbation of phenotypes, causing severe motor deficits, neurodegeneration and enhanced lysosome abnormalities and gliosis.	tmem106b	81-89	granulin	Mus musculus	95-98
33531878-9	2021	Plasma concentrations of the biomarkers osteopontin and progranulin were elevated in CCI+FF mice compared to other experimental groups.	CCI	85-88	granulin	Mus musculus	56-67
33181174-0	2021	PGRN-/- TAMs-derived exosomes inhibit breast cancer cell invasion and migration and its mechanism exploration.	tams	8-12	granulin	Mus musculus	0-4
33181174-11	2021	PGRN-/- TAMs inhibited invasion, migration and EMT of breast cancer cells through their exosomes.	tams	8-12	granulin	Mus musculus	0-4