PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
32819966-0	2020	Erratum for Wang et al., "Cocarriage of Distinct bla KPC-2 and bla OXA-48 Plasmids in a Single Sequence Type 11 Carbapenem-Resistant Klebsiella pneumoniae Isolate".	Carbapenems	112-122	TEM beta-lactamase	Klebsiella pneumoniae	49-52
33999798-0	2021	Determination of incompatibility group plasmids and copy number of the bla NDM-1 gene in carbapenem-resistant Klebsiella pneumoniae strains recovered from different hospitals in Kerman, Iran.	Carbapenems	89-99	TEM beta-lactamase	Klebsiella pneumoniae	71-74
33999798-15	2021	Therefore, due to the identification of different replicon types in this study, the type and genetic characteristics of bla NDM-1-carrying plasmids, and other factors such as antibiotic selective pressure, probably affect the copy number of bla NDM-1 and change the MIC level to imipenem.	Imipenem	279-287	TEM beta-lactamase	Klebsiella pneumoniae	120-123
33999798-15	2021	Therefore, due to the identification of different replicon types in this study, the type and genetic characteristics of bla NDM-1-carrying plasmids, and other factors such as antibiotic selective pressure, probably affect the copy number of bla NDM-1 and change the MIC level to imipenem.	Imipenem	279-287	TEM beta-lactamase	Klebsiella pneumoniae	241-244
33139291-7	2020	Ceftazidime-avibactam was active against 9.1% of carbapenem-resistant E. coli (63.6% were bla NDM-producers) and 84.6% of K. pneumoniae (74.3% were bla KPC-producers) isolates.	Ceftazidime	0-11	TEM beta-lactamase	Klebsiella pneumoniae	148-151
33139291-7	2020	Ceftazidime-avibactam was active against 9.1% of carbapenem-resistant E. coli (63.6% were bla NDM-producers) and 84.6% of K. pneumoniae (74.3% were bla KPC-producers) isolates.	avibactam	12-21	TEM beta-lactamase	Klebsiella pneumoniae	148-151
33139291-8	2020	Most (90.1%) bla KPC-2-producers were susceptible to ceftazidime-avibactam.	avibactam, ceftazidime drug combination	53-74	TEM beta-lactamase	Klebsiella pneumoniae	13-16
32819966-0	2020	Erratum for Wang et al., "Cocarriage of Distinct bla KPC-2 and bla OXA-48 Plasmids in a Single Sequence Type 11 Carbapenem-Resistant Klebsiella pneumoniae Isolate".	Carbapenems	112-122	TEM beta-lactamase	Klebsiella pneumoniae	63-66
32477310-0	2020	Fourth Generation Cephalosporin Resistance Among Salmonella enterica Serovar Enteritidis Isolates in Shanghai, China Conferred by bla CTX-M-55 Harboring Plasmids.	Cephalosporins	18-31	TEM beta-lactamase	Klebsiella pneumoniae	130-133
32477310-13	2020	The present study demonstrated that the bla CTX-M-55 gene mobilized by ISEcp1- bla CTX-M-55-ORF477 was the main feature shared by CRSE isolates and seems to play an important role for transmission of cefepime resistance.	Cefepime	200-208	TEM beta-lactamase	Klebsiella pneumoniae	40-43
32477310-13	2020	The present study demonstrated that the bla CTX-M-55 gene mobilized by ISEcp1- bla CTX-M-55-ORF477 was the main feature shared by CRSE isolates and seems to play an important role for transmission of cefepime resistance.	Cefepime	200-208	TEM beta-lactamase	Klebsiella pneumoniae	79-82
32477310-14	2020	The number of CRSE isolates is rising annually, and the strong dissemination ability of ISEcp1-bla CTX-M-55-ORF477-harboring plasmids among different species represents an important threat to the therapeutic effectiveness of cefepime.	Cefepime	225-233	TEM beta-lactamase	Klebsiella pneumoniae	95-98
30962338-0	2019	Cocarriage of Distinct bla KPC-2 and bla OXA-48 Plasmids in a Single Sequence Type 11 Carbapenem-Resistant Klebsiella pneumoniae Isolate.	Carbapenems	86-96	TEM beta-lactamase	Klebsiella pneumoniae	23-26
31594809-4	2019	Carbapenem resistance in Citrobacter freundii, Enterobacter cloacae, Klebsiella aerogenes, and Klebsiella pneumoniae was linked to a pair of plasmids, each carrying the Klebsiella pneumoniae carbapenemase gene (bla KPC).	Carbapenems	0-10	TEM beta-lactamase	Klebsiella pneumoniae	211-214
31571938-6	2019	Overall, bla SHV, bla CTX-M, tetA and sul1 resistance genes found in 100% of the isolates, followed by bla TEM (95.8%), oqxA/B (91.7%), qnrB (87.5%), aac(6")Ib-cr (83.3%), bla DHA (79.2%), rmtB (66.7%), qnrS (54.2%), cat(54.2%), floR (50.0%), sul2 (45.8%) cmlA (20.8%)andbla CMY (8.33%), respectively.	docosahexaenoylascorbic acid	176-179	TEM beta-lactamase	Klebsiella pneumoniae	9-12
31571938-7	2019	What" more, seven bla CTX-M subtypes [bla CTX-M-14 (n=18), bla CTX-M-3(n=11), bla CTX-M-65 (n=4), bla CTX-M-15 (n=3), bla CTX-M-28 (n=2), bla CTX-M-55 (n=2), bla CTX-M-22 (n=1)] and six bla SHV subtypes [bla SHV-12(n=16), bla SHV-11 (n=4), bla SHV-2a(n=1), bla SHV-1(n=1), bla SHV-38(n=1) and bla SHV-28(n=1)] were detected.	ciguatoxin 1B (CTX 1B)	142-150	TEM beta-lactamase	Klebsiella pneumoniae	18-21
31413597-1	2019	Background: A rare member of metallo-beta-lactamases genes, bla SIM-1, carried by a 316-kb plasmid designated pSIM-1-BJ01 was isolated from a clinical cephalosporins- and carbapenem-resistant Klebsiella pneumoniae 13624.	Cephalosporins	151-165	TEM beta-lactamase	Klebsiella pneumoniae	60-63
31413597-1	2019	Background: A rare member of metallo-beta-lactamases genes, bla SIM-1, carried by a 316-kb plasmid designated pSIM-1-BJ01 was isolated from a clinical cephalosporins- and carbapenem-resistant Klebsiella pneumoniae 13624.	Carbapenems	171-181	TEM beta-lactamase	Klebsiella pneumoniae	60-63
26351485-5	2015	Carbapenem resistant strains were identified by the Modified Hodge Test based on CLSI instruction and PCR for surveying the presence of bla -KPC gene.	Carbapenems	0-10	TEM beta-lactamase	Klebsiella pneumoniae	136-139
31424008-1	2019	Introduction: Carbapenem resistance (CR) in Klebsiella pneumoniae is mainly mediated by bla NDM and bla OXA-48 carbapenemases.	Carbapenems	14-24	TEM beta-lactamase	Klebsiella pneumoniae	88-91
31424008-1	2019	Introduction: Carbapenem resistance (CR) in Klebsiella pneumoniae is mainly mediated by bla NDM and bla OXA-48 carbapenemases.	Carbapenems	14-24	TEM beta-lactamase	Klebsiella pneumoniae	100-103
31424008-1	2019	Introduction: Carbapenem resistance (CR) in Klebsiella pneumoniae is mainly mediated by bla NDM and bla OXA-48 carbapenemases.	Chromium	37-39	TEM beta-lactamase	Klebsiella pneumoniae	88-91
31424008-1	2019	Introduction: Carbapenem resistance (CR) in Klebsiella pneumoniae is mainly mediated by bla NDM and bla OXA-48 carbapenemases.	Chromium	37-39	TEM beta-lactamase	Klebsiella pneumoniae	100-103
31424008-2	2019	Newer Food and Drug Administration-approved antimicrobial ceftazidime/avibactam (C/A) has a potent activity against bla OXA-48-like producers.	Ceftazidime	58-69	TEM beta-lactamase	Klebsiella pneumoniae	116-119
31424008-2	2019	Newer Food and Drug Administration-approved antimicrobial ceftazidime/avibactam (C/A) has a potent activity against bla OXA-48-like producers.	avibactam	70-79	TEM beta-lactamase	Klebsiella pneumoniae	116-119
28747788-3	2017	BSC resistance was found in 9 (27.3%) isolates, all from post-craniotomy meningitis, harboring bla SHV-5 (n = 6), bla CMY-2 (n = 2), bla DHA-1 (n = 2), and bla TEM-1B (n = 1).	bsc	0-3	TEM beta-lactamase	Klebsiella pneumoniae	95-98
28747788-3	2017	BSC resistance was found in 9 (27.3%) isolates, all from post-craniotomy meningitis, harboring bla SHV-5 (n = 6), bla CMY-2 (n = 2), bla DHA-1 (n = 2), and bla TEM-1B (n = 1).	bsc	0-3	TEM beta-lactamase	Klebsiella pneumoniae	114-117
28747788-3	2017	BSC resistance was found in 9 (27.3%) isolates, all from post-craniotomy meningitis, harboring bla SHV-5 (n = 6), bla CMY-2 (n = 2), bla DHA-1 (n = 2), and bla TEM-1B (n = 1).	bsc	0-3	TEM beta-lactamase	Klebsiella pneumoniae	114-117
27051575-0	2016	Successful treatment of a Carbapenem-resistant Klebsiella pneumoniae carrying bla OXA-48 , bla VIM-2 , bla CMY-2 and bla SHV- with high dose combination of imipenem and amikacin.	Carbapenems	26-36	TEM beta-lactamase	Klebsiella pneumoniae	78-81
27051575-0	2016	Successful treatment of a Carbapenem-resistant Klebsiella pneumoniae carrying bla OXA-48 , bla VIM-2 , bla CMY-2 and bla SHV- with high dose combination of imipenem and amikacin.	Carbapenems	26-36	TEM beta-lactamase	Klebsiella pneumoniae	91-94
27051575-0	2016	Successful treatment of a Carbapenem-resistant Klebsiella pneumoniae carrying bla OXA-48 , bla VIM-2 , bla CMY-2 and bla SHV- with high dose combination of imipenem and amikacin.	Carbapenems	26-36	TEM beta-lactamase	Klebsiella pneumoniae	91-94
27051575-0	2016	Successful treatment of a Carbapenem-resistant Klebsiella pneumoniae carrying bla OXA-48 , bla VIM-2 , bla CMY-2 and bla SHV- with high dose combination of imipenem and amikacin.	Carbapenems	26-36	TEM beta-lactamase	Klebsiella pneumoniae	91-94
27051575-0	2016	Successful treatment of a Carbapenem-resistant Klebsiella pneumoniae carrying bla OXA-48 , bla VIM-2 , bla CMY-2 and bla SHV- with high dose combination of imipenem and amikacin.	Imipenem	156-164	TEM beta-lactamase	Klebsiella pneumoniae	78-81
27051575-0	2016	Successful treatment of a Carbapenem-resistant Klebsiella pneumoniae carrying bla OXA-48 , bla VIM-2 , bla CMY-2 and bla SHV- with high dose combination of imipenem and amikacin.	Imipenem	156-164	TEM beta-lactamase	Klebsiella pneumoniae	91-94
27051575-0	2016	Successful treatment of a Carbapenem-resistant Klebsiella pneumoniae carrying bla OXA-48 , bla VIM-2 , bla CMY-2 and bla SHV- with high dose combination of imipenem and amikacin.	Imipenem	156-164	TEM beta-lactamase	Klebsiella pneumoniae	91-94
27051575-0	2016	Successful treatment of a Carbapenem-resistant Klebsiella pneumoniae carrying bla OXA-48 , bla VIM-2 , bla CMY-2 and bla SHV- with high dose combination of imipenem and amikacin.	Imipenem	156-164	TEM beta-lactamase	Klebsiella pneumoniae	91-94
27051575-0	2016	Successful treatment of a Carbapenem-resistant Klebsiella pneumoniae carrying bla OXA-48 , bla VIM-2 , bla CMY-2 and bla SHV- with high dose combination of imipenem and amikacin.	Amikacin	169-177	TEM beta-lactamase	Klebsiella pneumoniae	78-81
27051575-0	2016	Successful treatment of a Carbapenem-resistant Klebsiella pneumoniae carrying bla OXA-48 , bla VIM-2 , bla CMY-2 and bla SHV- with high dose combination of imipenem and amikacin.	Amikacin	169-177	TEM beta-lactamase	Klebsiella pneumoniae	91-94
27051575-0	2016	Successful treatment of a Carbapenem-resistant Klebsiella pneumoniae carrying bla OXA-48 , bla VIM-2 , bla CMY-2 and bla SHV- with high dose combination of imipenem and amikacin.	Amikacin	169-177	TEM beta-lactamase	Klebsiella pneumoniae	91-94
27051575-0	2016	Successful treatment of a Carbapenem-resistant Klebsiella pneumoniae carrying bla OXA-48 , bla VIM-2 , bla CMY-2 and bla SHV- with high dose combination of imipenem and amikacin.	Amikacin	169-177	TEM beta-lactamase	Klebsiella pneumoniae	91-94
24252194-8	2014	In particular, 7/9 isolates harbouring bla NDM-1 were positive for these quinolone resistance genes, of which five carried qnrS1 and two carried qnrS1 and qnrB4.	Quinolones	73-82	TEM beta-lactamase	Klebsiella pneumoniae	39-42
22617551-0	2012	The bla(CTX-M) gene independently enhances drug resistance level to ampicillin in clinical isolates of Klebsiella pneumoniae.	Ampicillin	68-78	TEM beta-lactamase	Klebsiella pneumoniae	4-7
24428238-7	2014	bla(NDM) and bla(VIM) genes were identified in three and five carbapenem-resistant isolates, respectively.	Carbapenems	62-72	TEM beta-lactamase	Klebsiella pneumoniae	0-3
24428238-7	2014	bla(NDM) and bla(VIM) genes were identified in three and five carbapenem-resistant isolates, respectively.	Carbapenems	62-72	TEM beta-lactamase	Klebsiella pneumoniae	13-16
24858644-5	2014	In 39 out of 40 samples, we identified the bla(KPC-3) carbapenemase gene variant responsible for bacterial carbapenem resistance.	Carbapenems	54-64	TEM beta-lactamase	Klebsiella pneumoniae	43-46
24286084-1	2013	Cephalosporin resistance, particularly due to bla(TEM) encoded beta-lactamases, among Enterobacteriaceae is, though, an increasing public health problem in India; their circulating genetic variants remain unknown.	Cephalosporins	0-13	TEM beta-lactamase	Klebsiella pneumoniae	46-49
22964287-5	2012	Screening for cephalosporins-resistant E. coli and K. pneumoniae was performed by PCR assay for bla(TEM), bla(SHV), bla(CTX-M-1),(-2),(-8),(-9), bla(PER-2) and bla(CMY-2) genes.	Cephalosporins	14-28	TEM beta-lactamase	Klebsiella pneumoniae	96-99
22964287-5	2012	Screening for cephalosporins-resistant E. coli and K. pneumoniae was performed by PCR assay for bla(TEM), bla(SHV), bla(CTX-M-1),(-2),(-8),(-9), bla(PER-2) and bla(CMY-2) genes.	Cephalosporins	14-28	TEM beta-lactamase	Klebsiella pneumoniae	106-109
22964287-5	2012	Screening for cephalosporins-resistant E. coli and K. pneumoniae was performed by PCR assay for bla(TEM), bla(SHV), bla(CTX-M-1),(-2),(-8),(-9), bla(PER-2) and bla(CMY-2) genes.	Cephalosporins	14-28	TEM beta-lactamase	Klebsiella pneumoniae	106-109
22964287-5	2012	Screening for cephalosporins-resistant E. coli and K. pneumoniae was performed by PCR assay for bla(TEM), bla(SHV), bla(CTX-M-1),(-2),(-8),(-9), bla(PER-2) and bla(CMY-2) genes.	Cephalosporins	14-28	TEM beta-lactamase	Klebsiella pneumoniae	106-109
22964287-5	2012	Screening for cephalosporins-resistant E. coli and K. pneumoniae was performed by PCR assay for bla(TEM), bla(SHV), bla(CTX-M-1),(-2),(-8),(-9), bla(PER-2) and bla(CMY-2) genes.	Cephalosporins	14-28	TEM beta-lactamase	Klebsiella pneumoniae	106-109
24813687-1	2014	Three ertapenem-resistant Klebsiella pneumoniae carrying bla(KPC-2) were isolated from a single patient in Nebraska over a span of 5 months.	Ertapenem	6-15	TEM beta-lactamase	Klebsiella pneumoniae	57-60
24033858-4	2013	MICs to beta-lactams in E. coli W4573 and its acrAB mutant strain increased 1- to 500-fold (MIC from 0.125 to 64 mug mL(-1) of aztreonam) in the bla(KPC-2a), bla(KPC-2b), and bla(KPC-2c) transformants compared with the cloning vector alone.	beta-Lactams	8-20	TEM beta-lactamase	Klebsiella pneumoniae	145-148
24033858-4	2013	MICs to beta-lactams in E. coli W4573 and its acrAB mutant strain increased 1- to 500-fold (MIC from 0.125 to 64 mug mL(-1) of aztreonam) in the bla(KPC-2a), bla(KPC-2b), and bla(KPC-2c) transformants compared with the cloning vector alone.	beta-Lactams	8-20	TEM beta-lactamase	Klebsiella pneumoniae	158-161
24033858-4	2013	MICs to beta-lactams in E. coli W4573 and its acrAB mutant strain increased 1- to 500-fold (MIC from 0.125 to 64 mug mL(-1) of aztreonam) in the bla(KPC-2a), bla(KPC-2b), and bla(KPC-2c) transformants compared with the cloning vector alone.	beta-Lactams	8-20	TEM beta-lactamase	Klebsiella pneumoniae	158-161
24033858-4	2013	MICs to beta-lactams in E. coli W4573 and its acrAB mutant strain increased 1- to 500-fold (MIC from 0.125 to 64 mug mL(-1) of aztreonam) in the bla(KPC-2a), bla(KPC-2b), and bla(KPC-2c) transformants compared with the cloning vector alone.	Aztreonam	127-136	TEM beta-lactamase	Klebsiella pneumoniae	145-148
24033858-4	2013	MICs to beta-lactams in E. coli W4573 and its acrAB mutant strain increased 1- to 500-fold (MIC from 0.125 to 64 mug mL(-1) of aztreonam) in the bla(KPC-2a), bla(KPC-2b), and bla(KPC-2c) transformants compared with the cloning vector alone.	Aztreonam	127-136	TEM beta-lactamase	Klebsiella pneumoniae	158-161
24033858-4	2013	MICs to beta-lactams in E. coli W4573 and its acrAB mutant strain increased 1- to 500-fold (MIC from 0.125 to 64 mug mL(-1) of aztreonam) in the bla(KPC-2a), bla(KPC-2b), and bla(KPC-2c) transformants compared with the cloning vector alone.	Aztreonam	127-136	TEM beta-lactamase	Klebsiella pneumoniae	158-161
24033858-6	2013	Levels of the three promoters" length and carbapenemase activities in the transformants harboring the bla(KPC-2a), bla(KPC-2b), and bla(KPC-2c) were correlated to the levels of beta-lactam MICs in both E. coli W4573 and its mutant of an efflux pump (AcrAB).	beta-Lactams	177-188	TEM beta-lactamase	Klebsiella pneumoniae	102-105
24033858-6	2013	Levels of the three promoters" length and carbapenemase activities in the transformants harboring the bla(KPC-2a), bla(KPC-2b), and bla(KPC-2c) were correlated to the levels of beta-lactam MICs in both E. coli W4573 and its mutant of an efflux pump (AcrAB).	beta-Lactams	177-188	TEM beta-lactamase	Klebsiella pneumoniae	115-118
24033858-6	2013	Levels of the three promoters" length and carbapenemase activities in the transformants harboring the bla(KPC-2a), bla(KPC-2b), and bla(KPC-2c) were correlated to the levels of beta-lactam MICs in both E. coli W4573 and its mutant of an efflux pump (AcrAB).	beta-Lactams	177-188	TEM beta-lactamase	Klebsiella pneumoniae	115-118
24033858-7	2013	Overall, these results suggest that promoter-deletions of bla(KPC-2) gene and AcrAB may be associated with the variability in beta-lactam MICs in KPC-producing Enterobacteriaceae.	beta-Lactams	126-137	TEM beta-lactamase	Klebsiella pneumoniae	58-61
23453788-3	2013	Two carbapenem-resistant Klebsiella pneumoniae isolates (NC12 and NC18) were found to harbor bla(NDM-1).	Carbapenems	4-14	TEM beta-lactamase	Klebsiella pneumoniae	93-96
23295924-1	2013	We report the nucleotide sequence of a novel bla(KPC-2)-harboring IncFII(K1) plasmid, pBK32179, isolated from a carbapenem-resistant Klebsiella pneumoniae ST258 strain from a New York City patient.	Carbapenems	112-122	TEM beta-lactamase	Klebsiella pneumoniae	45-48
22992193-8	2013	The DNA sequences upstream and downstream of bla(IMP) genes were determined, revealing that all IMP-encoding genes constituted the first cassette of class 1 integrons, followed by aacA gene cassettes encoding aminoglycoside resistance.	Aminoglycosides	209-223	TEM beta-lactamase	Klebsiella pneumoniae	45-48
22978676-0	2012	Molecular characterization of the bla(KPC-2) gene in clinical isolates of carbapenem-resistant  Klebsiella pneumoniae  from the pediatric wards of a Chinese hospital.	Carbapenems	74-84	TEM beta-lactamase	Klebsiella pneumoniae	34-37
20673270-1	2011	Between June 2007 and January 2008, 26 Klebsiella pneumoniae isolates carrying bla(DHA-1) on an IncL/M plasmid were obtained from clinical samples at Granollers Hospital, Barcelona, Spain.	dehydroacetic acid	83-86	TEM beta-lactamase	Klebsiella pneumoniae	79-82
17204406-4	2007	Addition of 300 mg/L 3-aminophenylboronic acid (APB) reduced the minimum inhibitory concentration for 90% of the organisms (MIC(90)) of imipenem and meropenem eight- and four-fold, respectively, for the bla(CMY-2)- and bla(DHA-1)-positive isolates, confirming the role of these enzymes in resistance.	3-aminobenzeneboronic acid	21-46	TEM beta-lactamase	Klebsiella pneumoniae	203-206
21359845-7	2011	The results show that in Recife, Brazil, K. pneumoniae isolates that presented resistance to oxyimino-beta-lactams had high prevalence and diversity of the bla (SHV) gene.	oxyimino-beta-lactams	93-114	TEM beta-lactamase	Klebsiella pneumoniae	156-159
21035968-8	2011	Four novel variants (bla(OKP-A-13), bla(OKP-A-14), bla(OKP-A-15), and bla(OKP-A-16)) were identified among the 10 OKP beta-lactamase-producing K. pneumoniae isolates resistant to ampicillin, amoxicillin, oxacillin, cefalexin, and cefadroxil.	Ampicillin	179-189	TEM beta-lactamase	Klebsiella pneumoniae	21-24
21035968-8	2011	Four novel variants (bla(OKP-A-13), bla(OKP-A-14), bla(OKP-A-15), and bla(OKP-A-16)) were identified among the 10 OKP beta-lactamase-producing K. pneumoniae isolates resistant to ampicillin, amoxicillin, oxacillin, cefalexin, and cefadroxil.	Amoxicillin	191-202	TEM beta-lactamase	Klebsiella pneumoniae	21-24
21035968-8	2011	Four novel variants (bla(OKP-A-13), bla(OKP-A-14), bla(OKP-A-15), and bla(OKP-A-16)) were identified among the 10 OKP beta-lactamase-producing K. pneumoniae isolates resistant to ampicillin, amoxicillin, oxacillin, cefalexin, and cefadroxil.	Oxacillin	204-213	TEM beta-lactamase	Klebsiella pneumoniae	21-24
21035968-8	2011	Four novel variants (bla(OKP-A-13), bla(OKP-A-14), bla(OKP-A-15), and bla(OKP-A-16)) were identified among the 10 OKP beta-lactamase-producing K. pneumoniae isolates resistant to ampicillin, amoxicillin, oxacillin, cefalexin, and cefadroxil.	Cephalexin	215-224	TEM beta-lactamase	Klebsiella pneumoniae	21-24
21035968-8	2011	Four novel variants (bla(OKP-A-13), bla(OKP-A-14), bla(OKP-A-15), and bla(OKP-A-16)) were identified among the 10 OKP beta-lactamase-producing K. pneumoniae isolates resistant to ampicillin, amoxicillin, oxacillin, cefalexin, and cefadroxil.	Cefadroxil	230-240	TEM beta-lactamase	Klebsiella pneumoniae	21-24
21189345-1	2011	Among 39 carbapenem-resistant Enterobacteriaceae (2.7% overall; Escherichia coli, Enterobacter cloacae, and Klebsiella pneumoniae strains) isolated in 2006 and 2007 in India, 15 strains carried bla(NDM-1) and 10 harbored a gene encoding a variant of the carbapenemase OXA-48, named bla(OXA-181).	Carbapenems	9-19	TEM beta-lactamase	Klebsiella pneumoniae	194-197
21189345-1	2011	Among 39 carbapenem-resistant Enterobacteriaceae (2.7% overall; Escherichia coli, Enterobacter cloacae, and Klebsiella pneumoniae strains) isolated in 2006 and 2007 in India, 15 strains carried bla(NDM-1) and 10 harbored a gene encoding a variant of the carbapenemase OXA-48, named bla(OXA-181).	Carbapenems	9-19	TEM beta-lactamase	Klebsiella pneumoniae	282-285
20547789-2	2010	This plasmid carries several important resistance determinants, such as bla(KPC-2), bla(DHA-1), qnrB4, and armA, which confer resistance to carbapenems, cephalosporins, fluoroquinolones, and aminoglycosides, respectively.	Carbapenems	140-151	TEM beta-lactamase	Klebsiella pneumoniae	72-75
20547789-2	2010	This plasmid carries several important resistance determinants, such as bla(KPC-2), bla(DHA-1), qnrB4, and armA, which confer resistance to carbapenems, cephalosporins, fluoroquinolones, and aminoglycosides, respectively.	Carbapenems	140-151	TEM beta-lactamase	Klebsiella pneumoniae	84-87
20547789-2	2010	This plasmid carries several important resistance determinants, such as bla(KPC-2), bla(DHA-1), qnrB4, and armA, which confer resistance to carbapenems, cephalosporins, fluoroquinolones, and aminoglycosides, respectively.	Cephalosporins	153-167	TEM beta-lactamase	Klebsiella pneumoniae	72-75
20547789-2	2010	This plasmid carries several important resistance determinants, such as bla(KPC-2), bla(DHA-1), qnrB4, and armA, which confer resistance to carbapenems, cephalosporins, fluoroquinolones, and aminoglycosides, respectively.	Cephalosporins	153-167	TEM beta-lactamase	Klebsiella pneumoniae	84-87
20547789-2	2010	This plasmid carries several important resistance determinants, such as bla(KPC-2), bla(DHA-1), qnrB4, and armA, which confer resistance to carbapenems, cephalosporins, fluoroquinolones, and aminoglycosides, respectively.	Fluoroquinolones	169-185	TEM beta-lactamase	Klebsiella pneumoniae	72-75
20547789-2	2010	This plasmid carries several important resistance determinants, such as bla(KPC-2), bla(DHA-1), qnrB4, and armA, which confer resistance to carbapenems, cephalosporins, fluoroquinolones, and aminoglycosides, respectively.	Fluoroquinolones	169-185	TEM beta-lactamase	Klebsiella pneumoniae	84-87
20547789-2	2010	This plasmid carries several important resistance determinants, such as bla(KPC-2), bla(DHA-1), qnrB4, and armA, which confer resistance to carbapenems, cephalosporins, fluoroquinolones, and aminoglycosides, respectively.	Aminoglycosides	191-206	TEM beta-lactamase	Klebsiella pneumoniae	72-75
20547789-2	2010	This plasmid carries several important resistance determinants, such as bla(KPC-2), bla(DHA-1), qnrB4, and armA, which confer resistance to carbapenems, cephalosporins, fluoroquinolones, and aminoglycosides, respectively.	Aminoglycosides	191-206	TEM beta-lactamase	Klebsiella pneumoniae	84-87
19036932-5	2009	Subsequently, the bla(KPC) PCR assay was used to confirm the presence of bla(KPC) genes in any meropenem-resistant Klebsiella spp.	Meropenem	95-104	TEM beta-lactamase	Klebsiella pneumoniae	73-76
19036932-7	2009	The PCR assay was then used to confirm the presence of bla(KPC) in an additional 20 meropenem-resistant isolates from 16 patients.	Meropenem	84-93	TEM beta-lactamase	Klebsiella pneumoniae	55-58
18620848-2	2008	All strains harboured the bla(CTX-M-15) gene and presented minimum inhibitory concentrations for cefotaxime and ceftazidime of 256-1024 mg L(-1) and 16-512 mg L(-1), respectively, and eight of them showed different pulsed-field gel electrophoresis patterns.	Cefotaxime	97-107	TEM beta-lactamase	Klebsiella pneumoniae	26-29
18620848-2	2008	All strains harboured the bla(CTX-M-15) gene and presented minimum inhibitory concentrations for cefotaxime and ceftazidime of 256-1024 mg L(-1) and 16-512 mg L(-1), respectively, and eight of them showed different pulsed-field gel electrophoresis patterns.	Ceftazidime	112-123	TEM beta-lactamase	Klebsiella pneumoniae	26-29
17276039-9	2007	The results demonstrate that differential expression of bla(SHV) in clinical isolates of K. pneumoniae can affect susceptibility to ampicillin.	Ampicillin	132-142	TEM beta-lactamase	Klebsiella pneumoniae	56-59
19015357-1	2009	A novel Klebsiella pneumoniae carbapenemase (KPC) variant, designated bla(KPC-5), was discovered in a carbapenem-resistant Pseudomonas aeruginosa clinical isolate from Puerto Rico.	Carbapenems	30-40	TEM beta-lactamase	Klebsiella pneumoniae	70-73
18990526-0	2009	Dissemination of bla(IMP-1)-carrying integron In86 among Klebsiella pneumoniae isolates harboring a new trimethoprim resistance gene dfr23.	Trimethoprim	104-116	TEM beta-lactamase	Klebsiella pneumoniae	17-20
17204406-4	2007	Addition of 300 mg/L 3-aminophenylboronic acid (APB) reduced the minimum inhibitory concentration for 90% of the organisms (MIC(90)) of imipenem and meropenem eight- and four-fold, respectively, for the bla(CMY-2)- and bla(DHA-1)-positive isolates, confirming the role of these enzymes in resistance.	3-aminobenzeneboronic acid	21-46	TEM beta-lactamase	Klebsiella pneumoniae	219-222
17204406-4	2007	Addition of 300 mg/L 3-aminophenylboronic acid (APB) reduced the minimum inhibitory concentration for 90% of the organisms (MIC(90)) of imipenem and meropenem eight- and four-fold, respectively, for the bla(CMY-2)- and bla(DHA-1)-positive isolates, confirming the role of these enzymes in resistance.	3-aminobenzeneboronic acid	48-51	TEM beta-lactamase	Klebsiella pneumoniae	203-206
17204406-4	2007	Addition of 300 mg/L 3-aminophenylboronic acid (APB) reduced the minimum inhibitory concentration for 90% of the organisms (MIC(90)) of imipenem and meropenem eight- and four-fold, respectively, for the bla(CMY-2)- and bla(DHA-1)-positive isolates, confirming the role of these enzymes in resistance.	3-aminobenzeneboronic acid	48-51	TEM beta-lactamase	Klebsiella pneumoniae	219-222
16854555-9	2007	Decreased susceptibility to carbapenems can occur in K. pneumoniae when bla(GES-3), bla(TEM-11), bla(SHV-12), bla(OXA-17), and/or bla(DHA-1) are produced in combination with porin loss.	Carbapenems	28-39	TEM beta-lactamase	Klebsiella pneumoniae	72-75
17276039-0	2007	Differential expression of bla(SHV) related to susceptibility to ampicillin in Klebsiella pneumoniae.	Ampicillin	65-75	TEM beta-lactamase	Klebsiella pneumoniae	27-30
17276039-2	2007	bla(SHV) is thought to be a key beta-lactamase gene responsible for this intrinsic resistance to ampicillin.	Ampicillin	97-107	TEM beta-lactamase	Klebsiella pneumoniae	0-3
17276039-3	2007	Nevertheless, surveys of clinical strains reveal that some isolates of K. pneumoniae that carry bla(SHV) remain susceptible to ampicillin.	Ampicillin	127-137	TEM beta-lactamase	Klebsiella pneumoniae	96-99
17276039-4	2007	To explore susceptibility to ampicillin in relation to bla(SHV) in K. pneumoniae, we analysed the existence and transcription of bla(SHV) and determined beta-lactamase activity as well as the susceptibilities to clinically relevant beta-lactams, including ampicillin in 160K.	Ampicillin	29-39	TEM beta-lactamase	Klebsiella pneumoniae	55-58
16854555-9	2007	Decreased susceptibility to carbapenems can occur in K. pneumoniae when bla(GES-3), bla(TEM-11), bla(SHV-12), bla(OXA-17), and/or bla(DHA-1) are produced in combination with porin loss.	Carbapenems	28-39	TEM beta-lactamase	Klebsiella pneumoniae	84-87
16854555-9	2007	Decreased susceptibility to carbapenems can occur in K. pneumoniae when bla(GES-3), bla(TEM-11), bla(SHV-12), bla(OXA-17), and/or bla(DHA-1) are produced in combination with porin loss.	Carbapenems	28-39	TEM beta-lactamase	Klebsiella pneumoniae	84-87
16854555-9	2007	Decreased susceptibility to carbapenems can occur in K. pneumoniae when bla(GES-3), bla(TEM-11), bla(SHV-12), bla(OXA-17), and/or bla(DHA-1) are produced in combination with porin loss.	Carbapenems	28-39	TEM beta-lactamase	Klebsiella pneumoniae	84-87
16854555-9	2007	Decreased susceptibility to carbapenems can occur in K. pneumoniae when bla(GES-3), bla(TEM-11), bla(SHV-12), bla(OXA-17), and/or bla(DHA-1) are produced in combination with porin loss.	Carbapenems	28-39	TEM beta-lactamase	Klebsiella pneumoniae	84-87
17005822-0	2006	High-level carbapenem resistance in a Klebsiella pneumoniae clinical isolate is due to the combination of bla(ACT-1) beta-lactamase production, porin OmpK35/36 insertional inactivation, and down-regulation of the phosphate transport porin phoe.	Carbapenems	11-21	TEM beta-lactamase	Klebsiella pneumoniae	106-109
11794541-5	2001	Sequence analysis showed that a new bla gene of pKP161 differed from bla(TEM-1) by three mutations leading to the following amino acid substitutions: Val84 --> Ile, Ala184 --> Val, and Gly238 --> Ser.	Isoleucine	163-166	TEM beta-lactamase	Klebsiella pneumoniae	36-39
15273099-9	2004	The bla(GES-4) gene found in strain KG502 might well emerge from a point mutation in the bla(GES-3) gene harbored by its ancestor strains, such as strain KG525, under heavy antibiotic stress in order to acquire extended properties of resistance to cephamycins and carbapenems.	Cephamycins	248-259	TEM beta-lactamase	Klebsiella pneumoniae	4-7
15273099-9	2004	The bla(GES-4) gene found in strain KG502 might well emerge from a point mutation in the bla(GES-3) gene harbored by its ancestor strains, such as strain KG525, under heavy antibiotic stress in order to acquire extended properties of resistance to cephamycins and carbapenems.	Cephamycins	248-259	TEM beta-lactamase	Klebsiella pneumoniae	89-92
15273099-9	2004	The bla(GES-4) gene found in strain KG502 might well emerge from a point mutation in the bla(GES-3) gene harbored by its ancestor strains, such as strain KG525, under heavy antibiotic stress in order to acquire extended properties of resistance to cephamycins and carbapenems.	Carbapenems	264-275	TEM beta-lactamase	Klebsiella pneumoniae	4-7
15273099-9	2004	The bla(GES-4) gene found in strain KG502 might well emerge from a point mutation in the bla(GES-3) gene harbored by its ancestor strains, such as strain KG525, under heavy antibiotic stress in order to acquire extended properties of resistance to cephamycins and carbapenems.	Carbapenems	264-275	TEM beta-lactamase	Klebsiella pneumoniae	89-92
14693555-2	2004	display a penicillinase-related beta-lactam resistance pattern suggesting the presence of a chromosomal bla gene.	beta-Lactams	32-43	TEM beta-lactamase	Klebsiella pneumoniae	104-107
16870645-16	2006	The Vipm-16 plasmid, mediating the higher imipenem MICs among transconjugants, carried two copies of bla(VIM-1).	Imipenem	42-50	TEM beta-lactamase	Klebsiella pneumoniae	101-104
16870645-18	2006	CONCLUSIONS: A VIM-1-producing strain of K. pneumoniae has evolved through OMP alterations and rearrangements in the bla(VIM-1)-carrying plasmid probably mediated by IS26, generating isolates with imipenem MICs ranging from susceptibility to resistance.	Imipenem	197-205	TEM beta-lactamase	Klebsiella pneumoniae	117-120
11864960-3	2002	RNA analysis using primer extension demonstrated a five-fold increase in bla(ACT-1) transcript production on exposure to cefoxitin.	Cefoxitin	121-130	TEM beta-lactamase	Klebsiella pneumoniae	73-76
11794541-5	2001	Sequence analysis showed that a new bla gene of pKP161 differed from bla(TEM-1) by three mutations leading to the following amino acid substitutions: Val84 --> Ile, Ala184 --> Val, and Gly238 --> Ser.	Isoleucine	163-166	TEM beta-lactamase	Klebsiella pneumoniae	69-72
35572689-0	2022	Emergence of a Hypervirulent Tigecycline-Resistant Klebsiella pneumoniae Strain Co-producing bla NDM-1 and bla KPC-2 With an Uncommon Sequence Type ST464 in Southwestern China.	Tigecycline	29-40	TEM beta-lactamase	Klebsiella pneumoniae	93-96
11502506-6	2001	Amino acid differences in comparison to the amino acid sequence of bla(SHV-1) were found at positions T18A (ThrACC-->AlaGCC), L35Q (LeuCTA-->GluCAA), and M129V (MetATG-->ValGTG) for SHV-25 and at position A187T (AlaGCC-->ThrACC) for SHV-26.	thracc	108-114	TEM beta-lactamase	Klebsiella pneumoniae	67-70
34512578-1	2021	We isolated and characterized a carbapenem-resistant Klebsiella pneumoniae (CRKP) clinical strain from blood carrying a novel bla OXA gene, bla OXA-926, and belonging to ST29, an uncommon CRKP type.	Carbapenems	32-42	TEM beta-lactamase	Klebsiella pneumoniae	126-129
34512578-1	2021	We isolated and characterized a carbapenem-resistant Klebsiella pneumoniae (CRKP) clinical strain from blood carrying a novel bla OXA gene, bla OXA-926, and belonging to ST29, an uncommon CRKP type.	Carbapenems	32-42	TEM beta-lactamase	Klebsiella pneumoniae	140-143
34512578-7	2021	bla OXA-926 was cloned and MICs of beta-lactams in the transformants were determined using microdilution.	beta-Lactams	35-47	TEM beta-lactamase	Klebsiella pneumoniae	0-3
34248878-9	2021	Those co-harboring bla CTX-M-65, bla SHV-182, and bla TEM-181 were significantly less resistant to beta-lactam than to other extended-spectrum beta-lactamases.	beta-Lactams	99-110	TEM beta-lactamase	Klebsiella pneumoniae	19-22
34248878-9	2021	Those co-harboring bla CTX-M-65, bla SHV-182, and bla TEM-181 were significantly less resistant to beta-lactam than to other extended-spectrum beta-lactamases.	beta-Lactams	99-110	TEM beta-lactamase	Klebsiella pneumoniae	33-36
34248878-9	2021	Those co-harboring bla CTX-M-65, bla SHV-182, and bla TEM-181 were significantly less resistant to beta-lactam than to other extended-spectrum beta-lactamases.	beta-Lactams	99-110	TEM beta-lactamase	Klebsiella pneumoniae	50-53
11794541-5	2001	Sequence analysis showed that a new bla gene of pKP161 differed from bla(TEM-1) by three mutations leading to the following amino acid substitutions: Val84 --> Ile, Ala184 --> Val, and Gly238 --> Ser.	Valine	150-153	TEM beta-lactamase	Klebsiella pneumoniae	36-39
11794541-5	2001	Sequence analysis showed that a new bla gene of pKP161 differed from bla(TEM-1) by three mutations leading to the following amino acid substitutions: Val84 --> Ile, Ala184 --> Val, and Gly238 --> Ser.	Valine	150-153	TEM beta-lactamase	Klebsiella pneumoniae	69-72
11794541-5	2001	Sequence analysis showed that a new bla gene of pKP161 differed from bla(TEM-1) by three mutations leading to the following amino acid substitutions: Val84 --> Ile, Ala184 --> Val, and Gly238 --> Ser.	Serine	205-208	TEM beta-lactamase	Klebsiella pneumoniae	36-39
11794541-5	2001	Sequence analysis showed that a new bla gene of pKP161 differed from bla(TEM-1) by three mutations leading to the following amino acid substitutions: Val84 --> Ile, Ala184 --> Val, and Gly238 --> Ser.	Serine	205-208	TEM beta-lactamase	Klebsiella pneumoniae	69-72
10639384-2	2000	The amino acid sequence deduced from the corresponding bla gene showed two amino acid replacements with respect to the TEM-2 sequence: Glu-104 to Lys and His-153 to Arg.	Arginine	165-168	TEM beta-lactamase	Klebsiella pneumoniae	55-58
35572689-0	2022	Emergence of a Hypervirulent Tigecycline-Resistant Klebsiella pneumoniae Strain Co-producing bla NDM-1 and bla KPC-2 With an Uncommon Sequence Type ST464 in Southwestern China.	Tigecycline	29-40	TEM beta-lactamase	Klebsiella pneumoniae	107-110
35572689-1	2022	Emergence of bla NDM-1 and bla KPC-2 co-producing Klebsiella pneumoniae strains is currently attracting widespread attention, but little information is available about their tigecycline resistance, virulence, and prevalence in Southwest China.	Tigecycline	174-185	TEM beta-lactamase	Klebsiella pneumoniae	13-16
35155355-0	2021	Microbial Characteristics and Genomic Analysis of an ST11 Carbapenem-Resistant Klebsiella pneumoniae Strain Carrying bla KPC-2 Conjugative Drug-Resistant Plasmid.	Carbapenems	58-68	TEM beta-lactamase	Klebsiella pneumoniae	117-120
35155355-1	2021	Background: The sequence type 11 (ST11) carbapenem-resistant Klebsiella pneumoniae (CRKP) carrying bla KPC-2 has been widespread all over the world, and it has been reported frequently in China.	Carbapenems	40-50	TEM beta-lactamase	Klebsiella pneumoniae	99-102
35155355-11	2021	In the drug-resistant plasmid pKPC-063001, the key carbapenem resistance gene bla KPC-2 was located in the genetic context with insertion sequence ISKpn27 upstream and ISKpn6 downstream and bracketed by IS26.	Carbapenems	51-61	TEM beta-lactamase	Klebsiella pneumoniae	78-81